Lipoprotein lipase
type: ProteinReference
xref: uniprot Q06000 21
organism: Rattus norvegicus

uniprot H2R0M0 4
type: UnificationXref
id: H2R0M0
db: uniprot

STATE_TRANSITION_LEFT__lyso_PI-RIGHT__2_AG-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 52
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 51
left: lyso-PI
interaction type: STATE_TRANSITION
right: 2-AG

DGL
type: Protein
entity reference: DGL
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2J8QDF6 29
type: UnificationXref
id: A0A2J8QDF6
db: uniprot

uniprot Q8WWY8 11
type: UnificationXref
id: Q8WWY8
db: uniprot

STATE_TRANSITION_LEFT__phosphatidylinositol-RIGHT__lyso_PI-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 53
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 54
left: phosphatidylinositol
interaction type: STATE_TRANSITION
right: lyso-PI

uniprot P11602 19
type: UnificationXref
id: P11602
db: uniprot

uniprot P11152 18
type: UnificationXref
id: P11152
db: uniprot

Lipoprotein lipase
type: ProteinReference
xref: uniprot F1PA62 12
organism: Canis lupus familiaris

uniprot F6ZKL2 35
type: UnificationXref
id: F6ZKL2
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A2J8QDF6 29
xref: PTHR10336:SF10
organism: Pan troglodytes

Lipoprotein lipase
type: ProteinReference
xref: uniprot P11602 19
organism: Gallus gallus

uniprot J9JHK9 37
type: UnificationXref
id: J9JHK9
db: uniprot

lyso-PLC
type: Protein
comment: SPECIES_TYPE=PROTEIN

Bos taurus
type: BioSource
xref: ncbitaxon 9913 17

Lipase member H
type: ProteinReference
xref: uniprot Q8WWY8 11
organism: Homo sapiens

uniprot A0A1D5Q4D0 24
type: UnificationXref
id: A0A1D5Q4D0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6SD46 33
xref: PTHR10336:SF12
organism: Monodelphis domestica

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 25

uniprot O89040 39
type: UnificationXref
id: O89040
db: uniprot

PANTHER Pathway P05726 1
type: UnificationXref
id: P05726
db: PANTHER Pathway

Sn1-specific diacylglycerol lipase alpha
type: ProteinReference
xref: uniprot Q5YLM1 22
organism: Rattus norvegicus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 10

By Homology
type: RelationshipTypeVocabulary

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 40

Phospholipase A1 member A
type: ProteinReference
xref: uniprot Q53H76 7
organism: Homo sapiens

uniprot H2QN58 2
type: UnificationXref
id: H2QN58
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10894 42
xref: PTHR10336:SF12
organism: Bos taurus

uniprot E2RT75 31
type: UnificationXref
id: E2RT75
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot O89040 39
xref: PTHR10336:SF10
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re2 56
type: Stoichiometry
physical entity: 1,2-DAG
stoichiometric coefficient: 1.0

PLC
type: Protein
entity reference: PLC
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot J9JHK9 37
xref: PTHR10336:SF11
organism: Canis lupus familiaris

P05738
type: UnificationXref
id: P05738
db: PANTHER Pathway Component

uniprot Q00722 44
type: UnificationXref
id: Q00722
db: uniprot

Phospholipase A1 member A
type: ProteinReference
xref: uniprot Q8VI78 9
organism: Mus musculus

P05736
type: UnificationXref
id: P05736
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re2 55
type: Stoichiometry
physical entity: phosphatidylinositol
stoichiometric coefficient: 1.0

P05735
type: UnificationXref
id: P05735
db: PANTHER Pathway Component

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 26

uniprot F6SD46 33
type: UnificationXref
id: F6SD46
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphatidylinositol-RIGHT__lyso_PI-_re3
controller: PLA1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10687 41
xref: PTHR10336:SF12
organism: Rattus norvegicus

uniprot P10687 41
type: UnificationXref
id: P10687
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot H9ZA60 36
xref: PTHR10336:SF10
organism: Macaca mulatta

ncbitaxon 13616 34
type: UnificationXref
id: 13616
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9Z1B3 48
xref: PTHR10336:SF12
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphatidylinositol-RIGHT__1,2_DAG-_re2
controller: PLC

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot K7BA21 38
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot Q00722 44
xref: PTHR10336:SF10
organism: Homo sapiens

PLA1
type: ProteinReference
xref: P05735
standard name: Phospholipase A1
comment: ENTITY_REFERENCE_NOTES=Long Name: Phospholipase A1 Synonym: Synonym not specified Accession: P05735
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC= 5-arachidonylglycerol_biosynthesis.PROTEIN.GENERIC.PLA1
member entity reference: Phospholipase A1 member A
member entity reference: LIPH isoform 1
member entity reference: Lipase member H
member entity reference: PLA1A isoform 1

STATE_TRANSITION_LEFT__phosphatidylinositol-RIGHT__1,2_DAG-_re2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 56
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 55
left: phosphatidylinositol
interaction type: STATE_TRANSITION
right: 1,2-DAG

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q01970 45
xref: PTHR10336:SF11
organism: Homo sapiens

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 6

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__lyso_PI-RIGHT__2_AG-_re4
controller: lyso-PLC

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 13

LIPH isoform 1
type: ProteinReference
xref: uniprot H2R0M0 4
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re3 54
type: Stoichiometry
physical entity: lyso-PI
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 53
type: Stoichiometry
physical entity: phosphatidylinositol
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 34

ncbitaxon 10090 10
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot H9ZA60 36
type: UnificationXref
id: H9ZA60
db: uniprot

uniprot Q9Z1B3 48
type: UnificationXref
id: Q9Z1B3
db: uniprot

Lipoprotein lipase
type: ProteinReference
xref: uniprot H2QVT7 14
organism: Pan troglodytes

uniprot K7BA21 38
type: UnificationXref
id: K7BA21
db: uniprot

1,2-DAG
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 20

phosphatidylinositol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A3KGF7 30
type: UnificationXref
id: A3KGF7
db: uniprot

uniprot F1PA62 12
type: UnificationXref
id: F1PA62
db: uniprot

uniprot P06858 15
type: UnificationXref
id: P06858
db: uniprot

uniprot Q53H76 7
type: UnificationXref
id: Q53H76
db: uniprot

uniprot Q01970 45
type: UnificationXref
id: Q01970
db: uniprot

PLA1A isoform 1
type: ProteinReference
xref: uniprot H2QN58 2
organism: Pan troglodytes

uniprot Q5YLM1 22
type: UnificationXref
id: Q5YLM1
db: uniprot

uniprot H2QVT7 14
type: UnificationXref
id: H2QVT7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot A3KGF7 30
xref: PTHR10336:SF10
organism: Mus musculus

lyso-PI
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 3

ncbitaxon 9598 3
type: UnificationXref
id: 9598
db: ncbitaxon

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

STATE_TRANSITION_LEFT__1,2_DAG-RIGHT__2_AG-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 49
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 50
left: 1,2-DAG
interaction type: STATE_TRANSITION
right: 2-AG

DGL
type: ProteinReference
xref: P05736
standard name: Diacylglycerol lipase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC= 5-arachidonylglycerol_biosynthesis.PROTEIN.GENERIC.DGL
comment: ENTITY_REFERENCE_NOTES=Long Name: Diacylglycerol lipase Synonym: Clearing factor lipase,Diglyceride lipase,Lipoprotein lipase Accession: P05736
member entity reference: Lipoprotein lipase
member entity reference: Sn1-specific diacylglycerol lipase alpha

uniprot P51432 43
type: UnificationXref
id: P51432
db: uniprot

ncbitaxon 9031 20
type: UnificationXref
id: 9031
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F1PL90 32
organism: Canis lupus familiaris

uniprot F1PL90 32
type: UnificationXref
id: F1PL90
db: uniprot

Lipoprotein lipase
type: ProteinReference
xref: uniprot P06858 15
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A1D5Q4D0 24
xref: PTHR10336:SF11
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re4 52
type: Stoichiometry
physical entity: 2-AG
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 8

uniprot P11151 16
type: UnificationXref
id: P11151
db: uniprot

PARTICIPANT STOICHIOMETRY re4 51
type: Stoichiometry
physical entity: lyso-PI
stoichiometric coefficient: 1.0

uniprot Q8VI78 9
type: UnificationXref
id: Q8VI78
db: uniprot

PTHR10336:SF11
type: RelationshipXref
id: PTHR10336:SF11
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF12
type: RelationshipXref
id: PTHR10336:SF12
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF10
type: RelationshipXref
id: PTHR10336:SF10
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3T8F7 28
type: UnificationXref
id: A0A2I3T8F7
db: uniprot

uniprot Q9NQ66 47
type: UnificationXref
id: Q9NQ66
db: uniprot

Lipoprotein lipase
type: ProteinReference
xref: uniprot P11151 16
organism: Bos taurus

Lipoprotein lipase
type: ProteinReference
xref: uniprot P11152 18
organism: Mus musculus

uniprot Q9Y4D2 23
type: UnificationXref
id: Q9Y4D2
db: uniprot

PARTICIPANT STOICHIOMETRY re5 49
type: Stoichiometry
physical entity: 1,2-DAG
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A2I3T8F7 28
xref: PTHR10336:SF11
organism: Pan troglodytes

ncbitaxon 9913 17
type: UnificationXref
id: 9913
db: ncbitaxon

ncbitaxon 9606 8
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q06000 21
type: UnificationXref
id: Q06000
db: uniprot

2-AG
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q99JE6 46
xref: PTHR10336:SF11
organism: Rattus norvegicus

eco ECO:0000250 26
type: UnificationXref
id: ECO:0000250
db: eco

ncbitaxon 9544 25
type: UnificationXref
id: 9544
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re5 50
type: Stoichiometry
physical entity: 2-AG
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot P51432 43
xref: PTHR10336:SF11
organism: Mus musculus

PLC
type: ProteinReference
xref: P05738
standard name: phospholipase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: phospholipase C Synonym: Phosphoinositidase C Accession: P05738
comment: ENTITY_REFERENCE_ID_DESC= 5-arachidonylglycerol_biosynthesis.PROTEIN.GENERIC.PLC
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

uniprot P97535 5
type: UnificationXref
id: P97535
db: uniprot

eco ECO:0000305 40
type: UnificationXref
id: ECO:0000305
db: eco

Sn1-specific diacylglycerol lipase alpha
type: ProteinReference
xref: uniprot Q9Y4D2 23
organism: Homo sapiens

uniprot P10894 42
type: UnificationXref
id: P10894
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot E2RT75 31
xref: PTHR10336:SF10
organism: Canis lupus familiaris

ncbitaxon 9615 13
type: UnificationXref
id: 9615
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6ZKL2 35
xref: PTHR10336:SF12
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__1,2_DAG-RIGHT__2_AG-_re5
controller: DGL

Phospholipase A1 member A
type: ProteinReference
xref: uniprot P97535 5
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9NQ66 47
xref: PTHR10336:SF12
organism: Homo sapiens

PLA1
type: Protein
entity reference: PLA1
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 10116 6
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot Q99JE6 46
type: UnificationXref
id: Q99JE6
db: uniprot

5-arachidonylglycerol_biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__1,2_DAG-RIGHT__2_AG-_re5
pathway component: STATE_TRANSITION_LEFT__phosphatidylinositol-RIGHT__1,2_DAG-_re2
pathway component: STATE_TRANSITION_LEFT__phosphatidylinositol-RIGHT__lyso_PI-_re3
pathway component: STATE_TRANSITION_LEFT__lyso_PI-RIGHT__2_AG-_re4
xref: PANTHER Pathway P05726 1
comment: MODEL_NOTES=2-arachydonoylglycerol is an endogenous lipids (or endocanabinoid compounds) that activates brain canabinoid receptors. This pathway illustrates 2 possible routes for its biosynthesis in neurons. Medline=12843414