uniprot Q8CGV2 35
type: UnificationXref
id: Q8CGV2
db: uniprot

uniprot F7B7G4 19
type: UnificationXref
id: F7B7G4
db: uniprot

uniprot G5EED8 23
type: UnificationXref
id: G5EED8
db: uniprot

uniprot A0A0R4ILE6 2
type: UnificationXref
id: A0A0R4ILE6
db: uniprot

uniprot P05031 47
type: UnificationXref
id: P05031
db: uniprot

Tryptophan hydroxylase 1
type: ProteinReference
xref: PTHR11473:SF23
xref: uniprot F1N5Q8 15
organism: Bos taurus

3,4-dihydroxyphenylacetaldehyde synthase
type: ProteinReference
xref: PTHR11999:SF60
xref: uniprot P18486 49
organism: Drosophila melanogaster

uniprot P34751 51
type: UnificationXref
id: P34751
db: uniprot

uniprot Q6IWP4 32
type: UnificationXref
id: Q6IWP4
db: uniprot

PTHR11473:SF23
type: RelationshipXref
id: PTHR11473:SF23
db: PANTHER Family
relationship type: By Homology

ncbitaxon 39947 53
type: UnificationXref
id: 39947
db: ncbitaxon

Tryptophan Hydroxylase
type: ProteinReference
xref: P04399
standard name: Tryptophan hydroxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Tryptophan hydroxylase Synonym: TPH Accession: P04399
comment: ENTITY_REFERENCE_ID_DESC= 5-Hydroxytryptamine biosynthesis.PROTEIN.GENERIC.Tryptophan Hydroxylase
member entity reference: Uncharacterized protein
member entity reference: Tryptophan 5-hydroxylase 2
member entity reference: Tph1b protein
member entity reference: Tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
member entity reference: Tryptophan 5-hydroxylase 1
member entity reference: Protein CBR-TPH-1
member entity reference: Tryptophan hydroxylase 2
member entity reference: Neuronal tryptophan hydroxylase
member entity reference: Tryptophan hydroxylase 1
member entity reference: Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
member entity reference: GH12537p
member entity reference: TPH2 isoform 5
member entity reference: TPH1 isoform 2
member entity reference: Tryptophan hydroxylase

ncbitaxon 9606 30
type: UnificationXref
id: 9606
db: ncbitaxon

Bos taurus
type: BioSource
xref: ncbitaxon 9913 14

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot P14173 48
xref: PTHR11999:SF70
organism: Rattus norvegicus

Tryptophan hydroxylase
type: ProteinReference
xref: uniprot G5EED8 23
xref: PTHR11473:SF37
organism: Caenorhabditis elegans

STATE_TRANSITION_LEFT__L_5_Hydroxytryptophan-RIGHT__5_Hydroxytryptamine__serotonin_-_CO2-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 60
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 61
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 59
left: L-5-Hydroxytryptophan
interaction type: STATE_TRANSITION
right: CO2
right: 5-Hydroxytryptamine (serotonin)

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 20

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot P05031 47
xref: PTHR11999:SF70
organism: Drosophila melanogaster

Mus musculus
type: BioSource
xref: ncbitaxon 10090 28

P04400
type: UnificationXref
id: P04400
db: PANTHER Pathway Component

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 46

PTHR11473:SF37
type: RelationshipXref
id: PTHR11473:SF37
db: PANTHER Family
relationship type: By Homology

uniprot P17752 29
type: UnificationXref
id: P17752
db: uniprot

Tryptophan 5-hydroxylase 1
type: ProteinReference
xref: uniprot A0A1L1RWF7 6
xref: PTHR11473:SF23
organism: Gallus gallus

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 38

uniprot E1BGX6 13
type: UnificationXref
id: E1BGX6
db: uniprot

PTHR11999:SF60
type: RelationshipXref
id: PTHR11999:SF60
db: PANTHER Family
relationship type: By Homology

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

uniprot A8X844 41
type: UnificationXref
id: A8X844
db: uniprot

TPH1 isoform 2
type: ProteinReference
xref: uniprot A0A2I3SMD3 8
xref: PTHR11473:SF23
organism: Pan troglodytes

uniprot O45138 44
type: UnificationXref
id: O45138
db: uniprot

Tryptophan hydroxylase 1
type: ProteinReference
xref: PTHR11473:SF23
xref: uniprot F6ZR26 17
organism: Xenopus tropicalis

GH12537p
type: ProteinReference
xref: uniprot Q9W0K2 37
xref: PTHR11473:SF37
organism: Drosophila melanogaster

Tryptophan hydroxylase
type: Protein
entity reference: Tryptophan Hydroxylase
comment: SPECIES_TYPE=PROTEIN

PTHR11999:SF59
type: RelationshipXref
id: PTHR11999:SF59
db: PANTHER Family
relationship type: By Homology

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 26

uniprot F1R1D3 16
type: UnificationXref
id: F1R1D3
db: uniprot

uniprot A8XGU6 11
type: UnificationXref
id: A8XGU6
db: uniprot

PTHR11999:SF70
type: RelationshipXref
id: PTHR11999:SF70
db: PANTHER Family
relationship type: By Homology

TPH2 isoform 5
type: ProteinReference
xref: uniprot A0A2I3TG35 10
xref: PTHR11473:SF16
organism: Pan troglodytes

uniprot Q8CGU9 34
type: UnificationXref
id: Q8CGU9
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 22

Tryptophan 5-hydroxylase 2
type: ProteinReference
xref: uniprot Q8IWU9 36
xref: PTHR11473:SF16
organism: Homo sapiens

ncbitaxon 13616 22
type: UnificationXref
id: 13616
db: ncbitaxon

PTHR11473:SF16
type: RelationshipXref
id: PTHR11473:SF16
db: PANTHER Family
relationship type: By Homology

Dopa decarboxylase
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot A0A2I3TP36 39
organism: Pan troglodytes

STATE_TRANSITION_LEFT__O2-_L_Tryptophan-RIGHT__L_5_Hydroxytryptophan-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 64
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 63
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 62
left: O2
left: L-Tryptophan
interaction type: STATE_TRANSITION
right: L-5-Hydroxytryptophan

L-Tryptophan
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O88533 45
type: UnificationXref
id: O88533
db: uniprot

ncbitaxon 7955 3
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot Q7G6M2 52
type: UnificationXref
id: Q7G6M2
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 7

ncbitaxon 9031 7
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot A8WNB9 40
type: UnificationXref
id: A8WNB9
db: uniprot

uniprot P17532 27
type: UnificationXref
id: P17532
db: uniprot

Biogenic Amine Synthesis related
type: ProteinReference
xref: uniprot O45137 43
xref: PTHR11999:SF70
organism: Caenorhabditis elegans

BAS-Like
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot O45138 44
organism: Caenorhabditis elegans

By Homology
type: RelationshipTypeVocabulary

Protein CBR-TDC-1
type: ProteinReference
xref: uniprot A8WNB9 40
organism: Caenorhabditis briggsae

Tph1b protein
type: ProteinReference
xref: PTHR11473:SF23
xref: uniprot Q6IWP4 32
organism: Danio rerio

uniprot Q94EE9 54
type: UnificationXref
id: Q94EE9
db: uniprot

Tyrosine decarboxylase
type: ProteinReference
xref: uniprot Q95ZS2 56
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: PTHR11473:SF23
xref: uniprot F7B7G4 19
organism: Macaca mulatta

Tryptophan 5-hydroxylase 2
type: ProteinReference
xref: uniprot Q8CGV2 35
xref: PTHR11473:SF16
organism: Mus musculus

uniprot Q6PKI7 33
type: UnificationXref
id: Q6PKI7
db: uniprot

eco ECO:0000501 46
type: UnificationXref
id: ECO:0000501
db: eco

uniprot F7FNW0 42
type: UnificationXref
id: F7FNW0
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 9

O2
type: SmallMolecule
comment: SPECIES_TYPE=ION

PARTICIPANT STOICHIOMETRY re8 63
type: Stoichiometry
physical entity: L-Tryptophan
stoichiometric coefficient: 1.0

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot O88533 45
xref: PTHR11999:SF70
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re8 62
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 18

CO2
type: SmallMolecule
comment: SPECIES_TYPE=ION

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

Protein CBR-TPH-1
type: ProteinReference
xref: uniprot A8XGU6 11
xref: PTHR11473:SF37
organism: Caenorhabditis briggsae

ncbitaxon 9913 14
type: UnificationXref
id: 9913
db: ncbitaxon

Probable tyrosine decarboxylase 2
type: ProteinReference
xref: uniprot Q9M0G4 57
organism: Arabidopsis thaliana

Tryptophan 5-hydroxylase 2
type: ProteinReference
xref: PTHR11473:SF16
xref: uniprot Q2HZ26 31
organism: Macaca mulatta

uniprot Q8IWU9 36
type: UnificationXref
id: Q8IWU9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__L_5_Hydroxytryptophan-RIGHT__5_Hydroxytryptamine__serotonin_-_CO2-_re9
controller: Aromatic L-amino acid decarboxylase

uniprot P20711 50
type: UnificationXref
id: P20711
db: uniprot

uniprot Q94I30 55
type: UnificationXref
id: Q94I30
db: uniprot

Tyrosine decarboxylase
type: ProteinReference
xref: uniprot Q94EE9 54
organism: Oryza sativa

ncbitaxon 9598 9
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot F7DGX6 21
type: UnificationXref
id: F7DGX6
db: uniprot

Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a
type: ProteinReference
xref: PTHR11473:SF23
xref: uniprot F1R1D3 16
organism: Danio rerio

uniprot A0A1L1RWF7 6
type: UnificationXref
id: A0A1L1RWF7
db: uniprot

ncbitaxon 6239 24
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q9W0K2 37
type: UnificationXref
id: Q9W0K2
db: uniprot

Protein CBR-BAS-1
type: ProteinReference
xref: uniprot A8X844 41
xref: PTHR11999:SF70
organism: Caenorhabditis briggsae

PARTICIPANT STOICHIOMETRY re8 64
type: Stoichiometry
physical entity: L-5-Hydroxytryptophan
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 61
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

Tryptophan 5-hydroxylase 1
type: ProteinReference
xref: PTHR11473:SF23
xref: uniprot P09810 25
organism: Rattus norvegicus

ncbitaxon 8364 18
type: UnificationXref
id: 8364
db: ncbitaxon

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

uniprot Q2HZ26 31
type: UnificationXref
id: Q2HZ26
db: uniprot

PARTICIPANT STOICHIOMETRY re9 60
type: Stoichiometry
physical entity: 5-Hydroxytryptamine (serotonin)
stoichiometric coefficient: 1.0

Tryptophan hydroxylase 2
type: ProteinReference
xref: uniprot E1BGX6 13
xref: PTHR11473:SF16
organism: Bos taurus

uniprot A0A2I3SMD3 8
type: UnificationXref
id: A0A2I3SMD3
db: uniprot

ncbitaxon 7227 38
type: UnificationXref
id: 7227
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re9 59
type: Stoichiometry
physical entity: L-5-Hydroxytryptophan
stoichiometric coefficient: 1.0

uniprot O45137 43
type: UnificationXref
id: O45137
db: uniprot

Os10g0400500 protein
type: ProteinReference
xref: uniprot Q94I30 55
organism: Oryza sativa

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot P20711 50
organism: Homo sapiens

ncbitaxon 9544 20
type: UnificationXref
id: 9544
db: ncbitaxon

Tryptophan 5-hydroxylase 2
type: ProteinReference
xref: PTHR11473:SF16
xref: uniprot Q8CGU9 34
organism: Rattus norvegicus

ncbitaxon 10090 28
type: UnificationXref
id: 10090
db: ncbitaxon

L-5-Hydroxytryptophan
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P04399
type: UnificationXref
id: P04399
db: PANTHER Pathway Component

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 30

uniprot A0A2I3TG35 10
type: UnificationXref
id: A0A2I3TG35
db: uniprot

Aromatic L-amino acid decarboxylase
type: ProteinReference
xref: P04400
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC= 5-Hydroxytryptamine biosynthesis.PROTEIN.GENERIC.Aromatic L-amino acid_br_decarboxylase
member entity reference: Aromatic-L-amino-acid decarboxylase
member entity reference: Os10g0380800 protein
member entity reference: Probable aromatic-L-amino-acid decarboxylase
member entity reference: Dopa decarboxylase
member entity reference: Probable tyrosine decarboxylase 2
member entity reference: Protein CBR-TDC-1
member entity reference: Os10g0400500 protein
member entity reference: Tyrosine decarboxylase
member entity reference: 3,4-dihydroxyphenylacetaldehyde synthase
member entity reference: Biogenic Amine Synthesis related
member entity reference: Protein CBR-BAS-1
member entity reference: BAS-Like

ncbitaxon 6238 12
type: UnificationXref
id: 6238
db: ncbitaxon

ncbitaxon 10116 26
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot A0A2I3TP36 39
type: UnificationXref
id: A0A2I3TP36
db: uniprot

Tryptophan 5-hydroxylase 1
type: ProteinReference
xref: uniprot P17752 29
xref: PTHR11473:SF23
organism: Homo sapiens

ncbitaxon 3702 58
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot F6ZR26 17
type: UnificationXref
id: F6ZR26
db: uniprot

Aromatic L-amino acid decarboxylase
type: Protein
entity reference: Aromatic L-amino acid decarboxylase
comment: SPECIES_TYPE=PROTEIN

5-Hydroxytryptamine (serotonin)
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 58

Probable aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot P34751 51
xref: PTHR11999:SF59
organism: Caenorhabditis elegans

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 12

Os10g0380800 protein
type: ProteinReference
xref: uniprot Q7G6M2 52
organism: Oryza sativa

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 24

uniprot Q9M0G4 57
type: UnificationXref
id: Q9M0G4
db: uniprot

uniprot P14173 48
type: UnificationXref
id: P14173
db: uniprot

uniprot P18486 49
type: UnificationXref
id: P18486
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 3

uniprot F1N5Q8 15
type: UnificationXref
id: F1N5Q8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__O2-_L_Tryptophan-RIGHT__L_5_Hydroxytryptophan-_re8
controller: Tryptophan hydroxylase

Uncharacterized protein
type: ProteinReference
xref: PTHR11473:SF23
xref: uniprot F7DGX6 21
organism: Monodelphis domestica

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 53

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot F7FNW0 42
xref: PTHR11999:SF70
organism: Macaca mulatta

uniprot Q95ZS2 56
type: UnificationXref
id: Q95ZS2
db: uniprot

Neuronal tryptophan hydroxylase
type: ProteinReference
xref: uniprot Q6PKI7 33
xref: PTHR11473:SF16
organism: Gallus gallus

Tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
type: ProteinReference
xref: uniprot A0A0R4ILE6 2
xref: PTHR11473:SF16
organism: Danio rerio

5-Hydroxytryptamine biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__L_5_Hydroxytryptophan-RIGHT__5_Hydroxytryptamine__serotonin_-_CO2-_re9
pathway component: STATE_TRANSITION_LEFT__O2-_L_Tryptophan-RIGHT__L_5_Hydroxytryptophan-_re8
xref: PANTHER Pathway P04371 1
comment: MODEL_NOTES=No pathway definition

Tryptophan 5-hydroxylase 1
type: ProteinReference
xref: PTHR11473:SF23
xref: uniprot P17532 27
organism: Mus musculus

PANTHER Pathway P04371 1
type: UnificationXref
id: P04371
db: PANTHER Pathway

uniprot P09810 25
type: UnificationXref
id: P09810
db: uniprot