BABO
type: Protein
entity reference: BABO
feature: BABO s14 sa7 rs1

PUT/ALP23B_ phosphoBABO_SARA/SMOX
type: Complex
component stoichiometry: SMOX s52 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 30STOICHIOMETRY ID COMPLEX
component stoichiometry: SARA s51 sa37 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 49STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 19STOICHIOMETRY ID COMPLEX
component: PUT
component: SMOX
component: ALP23B
component: SARA
component: BABO
feature: COMPLEX BINDING FEATURE s56 csa8 120
feature: COMPLEX BINDING FEATURE s56 csa8 126
feature: COMPLEX BINDING FEATURE s56 csa8 118
feature: COMPLEX BINDING FEATURE s56 csa8 122
feature: COMPLEX BINDING FEATURE s56 csa8 124
cellular location: early endosome

uniprot A1Z7L8 12
type: UnificationXref
id: A1Z7L8
db: uniprot

SARA s51 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

SMOX s52 sa38 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

BABO
type: ProteinReference
xref: P06220
standard name: baboon
comment: ENTITY_REFERENCE_ID_DESC=ALP23B_signaling_pathway.PROTEIN.RECEPTOR.BABO
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

DISSOCIATION_LEFT__proALP23B-RIGHT__ALP23B-_?-_re6
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 149
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 148
left: proALP23B
interaction type: DISSOCIATION
right: ?
right: ALP23B

ALP23B s27 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s61 sa31 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa31 117
feature: SMOX s61 sa31 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SMOX s84 sa54 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

HOMODIMER ID 18STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

DISSOCIATION_LEFT__phosphoSMOX__MED-RIGHT__SMOX-_MED-_re19
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 151
left: phosphoSMOX/ MED
interaction type: DISSOCIATION
right: SMOX
right: MED

MED
type: ProteinReference
xref: P06221
standard name: medea
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ALP23B_signaling_pathway.PROTEIN.GENERIC.MED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein mothers against dpp
member entity reference: Mothers against decapentaplegic homolog

proALP23B
type: Complex
component stoichiometry: HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
component: ALP23B
component: ?
feature: COMPLEX BINDING FEATURE s26 csa5 136
feature: COMPLEX BINDING FEATURE s26 csa5 134

PUT
type: Protein
entity reference: PUT

SMOX s84 sa54 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TRANSPORT_LEFT__proALP23B-RIGHT__proALP23B-_re5
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 155
left: proALP23B
interaction type: TRANSPORT
right: proALP23B

early endosome
type: CellularLocationVocabulary
xref: GO GO:0005769 5

BABO s5 sa2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 8

PARTICIPANT STOICHIOMETRY re23 204
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 203
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 143
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re9 142
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

BABO s71 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

P06218
type: UnificationXref
id: P06218
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re1 176
type: Stoichiometry
physical entity: PUT/ALP23B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 178
type: Stoichiometry
physical entity: PUT/ALP23B_ BABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 177
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX s61 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PTHR47992:SF25
type: RelationshipXref
id: PTHR47992:SF25
db: PANTHER Family
relationship type: By Homology

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 38
xref: PTHR13703:SF25
xref: uniprot O96660 37
organism: Drosophila melanogaster

P06219
type: UnificationXref
id: P06219
db: PANTHER Pathway Component

ALP23B
type: Protein
entity reference: ALP23B

P06227
type: UnificationXref
id: P06227
db: PANTHER Pathway Component

PUT
type: Protein
entity reference: PUT

P06226
type: UnificationXref
id: P06226
db: PANTHER Pathway Component

P06223
type: UnificationXref
id: P06223
db: PANTHER Pathway Component

P06222
type: UnificationXref
id: P06222
db: PANTHER Pathway Component

P06225
type: UnificationXref
id: P06225
db: PANTHER Pathway Component

PUT/ALP23B
type: Complex
component stoichiometry: HOMODIMER ID 27STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
component: ALP23B
component: PUT
feature: COMPLEX BINDING FEATURE s2 csa1 72
feature: COMPLEX BINDING FEATURE s2 csa1 74
cellular location: cytosol

P06224
type: UnificationXref
id: P06224
db: PANTHER Pathway Component

P06221
type: UnificationXref
id: P06221
db: PANTHER Pathway Component

P06220
type: UnificationXref
id: P06220
db: PANTHER Pathway Component

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

SMOX
type: Protein
entity reference: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s111 sa73 83
feature: SMOX s111 sa73 rs2
feature: SMOX s111 sa73 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 sa42 69
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s106 sa74 77
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PUT s34 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SMOX s73 sa43 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ALP23B
type: Protein
entity reference: ALP23B

BABO s59 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PUT/ALP23B_ phosphoBABO
type: Complex
component stoichiometry: HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 52STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 22STOICHIOMETRY ID COMPLEX
component: BABO
component: ALP23B
component: PUT
feature: COMPLEX BINDING FEATURE s19 csa3 94
feature: COMPLEX BINDING FEATURE s19 csa3 96
feature: COMPLEX BINDING FEATURE s19 csa3 92
cellular location: cytosol

SARA s37 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__phosphoSMOX_LACK-RIGHT__phosphoSMOX_LACK-_re25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 202
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 201
left: phosphoSMOX LACK
interaction type: STATE_TRANSITION
right: phosphoSMOX LACK

SARA
type: ProteinReference
xref: P06222
standard name: Smad anchor for receptor activation
comment: ENTITY_REFERENCE_ID_DESC=ALP23B_signaling_pathway.PROTEIN.RECEPTOR.SARA
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Zinc finger FYVE domain-containing protein

phosphoSMOX/ MED
type: Complex
component stoichiometry: HOMODIMER ID 40STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s91 sa57 STOICHIOMETRY ID COMPLEX
component: MED
component: SMOX
feature: COMPLEX BINDING FEATURE s87 csa11 86
feature: COMPLEX BINDING FEATURE s87 csa11 84
cellular location: cytosol

PUT
type: Protein
entity reference: PUT

PARTICIPANT STOICHIOMETRY re5 155
type: Stoichiometry
physical entity: proALP23B
stoichiometric coefficient: 1.0

HOMODIMER ID 27STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re5 154
type: Stoichiometry
physical entity: proALP23B
stoichiometric coefficient: 1.0

SMOX s73 sa43 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

SMOX s84 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 3.0

?
type: Protein

HETERODIMER_ASSOCIATION_LEFT__ALP23B-_PUT-RIGHT__PUT_ALP23B-_re2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 171
left: ALP23B
left: PUT
interaction type: HETERODIMER_ASSOCIATION
right: PUT/ALP23B

LACK s106 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

ALP23B
type: Protein
entity reference: ALP23B

Evidence 60
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0011655.html

SARA s60 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

PUT s69 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

ALP23B s58 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

uniprot Q9V853 35
type: UnificationXref
id: Q9V853
db: uniprot

proALP23B
type: Complex
component stoichiometry: HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
component: ALP23B
component: ?
feature: COMPLEX BINDING FEATURE s29 csa4 138
feature: COMPLEX BINDING FEATURE s29 csa4 140
cellular location: Golgi apparatus

PARTICIPANT STOICHIOMETRY re12 186
type: Stoichiometry
physical entity: PUT/ALP23B_ phosphoBABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 187
type: Stoichiometry
physical entity: PUT/ALP23B_ phosphoBABO_SARA/SMOX
stoichiometric coefficient: 1.0

ALP23B
type: Protein
entity reference: ALP23B

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 2

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa37 125
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

By Homology
type: RelationshipTypeVocabulary

HETERODIMER_ASSOCIATION_LEFT__SARA_SMOX-_PUT_ALP23B__phosphoBABO-RIGHT__PUT_ALP23B__phosphoBABO_SARA_SMOX-_re12
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 186
left: PUT/ALP23B_ phosphoBABO
left: SARA/SMOX
interaction type: HETERODIMER_ASSOCIATION
right: PUT/ALP23B_ phosphoBABO_SARA/SMOX

SMOX s52 sa38 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

PUT
type: Protein
entity reference: PUT

uniprot Q7K9H6 54
type: UnificationXref
id: Q7K9H6
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 6

STATE_TRANSITION_LEFT__SMOX-RIGHT__SMOX-_re16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 168
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 167
left: SMOX
interaction type: STATE_TRANSITION
right: SMOX

TRUNCATION
type: RelationshipTypeVocabulary

HOMODIMER ID 32STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s73 sa43 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa43 71
feature: SMOX s73 sa43 rs1
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

PTHR13703:SF25
type: RelationshipXref
id: PTHR13703:SF25
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re12 185
type: Stoichiometry
physical entity: SARA/SMOX
stoichiometric coefficient: 1.0

TRUNCATION_LEFT__ALP23B_full_length-RIGHT__?-_ALP23B-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 157
left: ALP23B full length
interaction type: TRUNCATION
right: ALP23B
right: ?

DISSOCIATION_LEFT__phosphoSMOX_LACK-RIGHT__LACK-_SMOX-_re26
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 200
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 199
left: phosphoSMOX LACK
interaction type: DISSOCIATION
right: LACK
right: SMOX

PUT
type: Protein
entity reference: PUT

uniprot O96660 37
type: UnificationXref
id: O96660
db: uniprot

PUT s12 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 144
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 145
left: PUT
interaction type: STATE_TRANSITION
right: PUT

PUT
type: Protein
entity reference: PUT

SMOX s52 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

eco ECO:0000501 9
type: UnificationXref
id: ECO:0000501
db: eco

phosphoSMOX LACK
type: Complex
component stoichiometry: SMOX s107 sa75 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s106 sa74 STOICHIOMETRY ID COMPLEX
component: SMOX
component: LACK
feature: COMPLEX BINDING FEATURE s105 csa14 78
feature: COMPLEX BINDING FEATURE s105 csa14 76
cellular location: cytosol

SARA s72 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

HOMODIMER ID 49STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

SMOX s99 sa62 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

ALP23B s49 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

BABO
type: Protein
entity reference: BABO
feature: BABO s32 sa19 rs1

00696
type: UnificationXref
id: MOD:00696
db: mod

PUT
type: Protein
entity reference: PUT

PUT s79 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PUT
type: Protein
entity reference: PUT

FUR1
type: Protein
entity reference: FUR1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 9

HOMODIMER ID 19STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re26 200
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

ALP23B
type: Protein
entity reference: ALP23B

BABO s5 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX s99 sa62 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MED
type: Protein
entity reference: MED
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re28 195
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 194
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__PUT-RIGHT__PUT-_re10
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 191
left: PUT
interaction type: TRANSPORT
right: PUT

PARTICIPANT STOICHIOMETRY re28 193
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

Target transcripts
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

PTHR23255:SF98
type: RelationshipXref
id: PTHR23255:SF98
db: PANTHER Family
relationship type: By Homology

BABO s59 sa29 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot Q9VQG9 42
type: UnificationXref
id: Q9VQG9
db: uniprot

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s84 sa54 rs2
feature: SMOX s84 sa54 rs1

ncbitaxon 7227 8
type: UnificationXref
id: 7227
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re4 158
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re4 157
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re4 156
type: Stoichiometry
physical entity: ALP23B full length
stoichiometric coefficient: 2.0

BABO s14 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

Protein mothers against dpp
type: ProteinReference
xref: uniprot P42003 61
organism: Drosophila melanogaster

? s31 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re22 205
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 206
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa30 115
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BABO
type: Protein
entity reference: BABO
feature: BABO s50 sa36 rs1

PTHR11848:SF263
type: RelationshipXref
id: PTHR11848:SF263
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re6 150
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PUT
type: Protein
entity reference: PUT

PUT s42 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

BABO s32 sa19 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

SMOX s38 sa26 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PUT_ALP23B__phosphoBABO_SARA_SMOX-RIGHT__ADP-_PUT_ALP23B__phosphoBABO_SARA__phosphoSMOX-_re14
controller: BABO

ALP23B s13 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

Receptor protein serine/threonine kinase
type: ProteinReference
evidence: Evidence 13
evidence: Evidence 14
xref: uniprot A1Z7L8 12
xref: PTHR23255:SF71
organism: Drosophila melanogaster

STATE_TRANSITION
type: RelationshipTypeVocabulary

SMOX s38 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

SMOX s97 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 2.0

ALP23B
type: Protein
entity reference: ALP23B

uniprot O62609 59
type: UnificationXref
id: O62609
db: uniprot

HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PUT_ALP23B__BABO-RIGHT__ADP-_PUT_ALP23B__phosphoBABO-_re3
controller: PUT

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s40 sa24 rs2
feature: SMOX s40 sa24 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re19 153
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s110 sa72 81
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__BABO-RIGHT__BABO-_re9
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 142
left: BABO
interaction type: TRANSPORT
right: BABO

PARTICIPANT STOICHIOMETRY re19 152
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 151
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 60
xref: PTHR13703:SF45
xref: uniprot O62609 59
organism: Drosophila melanogaster

PUT/ALP23B_ BABO
type: Complex
component stoichiometry: HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 28STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 17STOICHIOMETRY ID COMPLEX
component: ALP23B
component: PUT
component: BABO
feature: COMPLEX BINDING FEATURE s6 csa2 132
feature: COMPLEX BINDING FEATURE s6 csa2 130
feature: COMPLEX BINDING FEATURE s6 csa2 128
cellular location: cytosol

phosphoSMOX LACK
type: Complex
component stoichiometry: SMOX s111 sa73 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s110 sa72 STOICHIOMETRY ID COMPLEX
component: SMOX
component: LACK
feature: COMPLEX BINDING FEATURE s109 csa13 82
feature: COMPLEX BINDING FEATURE s109 csa13 80
cellular location: cytosol

? s25 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

GO GO:0005769 5
type: UnificationXref
id: GO:0005769
db: GO

HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

LACK s110 sa72 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase receptor
type: ProteinReference
evidence: Evidence 24
xref: uniprot A0A0B4KG59 23
xref: PTHR23255:SF98
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__ALP23B_full_length-RIGHT__?-_ALP23B-_re4
controller: FUR1

SMOX s111 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

ALP23B
type: Protein
entity reference: ALP23B

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__phosphoSMOX__MED-RIGHT__SMOX-_MED-_re19
controller: PPM1A

FUR1
type: ProteinReference
xref: P06227
standard name: furin 1
comment: ENTITY_REFERENCE_ID_DESC=ALP23B_signaling_pathway.PROTEIN.GENERIC.FUR1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Furin-like protease 1, isoforms 1/1-X/2

SMOX s38 sa26 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re6 148
type: Stoichiometry
physical entity: proALP23B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 149
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

PPM1A
type: Protein
entity reference: PPM1A
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__SMOX-_LACK-RIGHT__phosphoSMOX_LACK-_re28
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 194
left: LACK
left: SMOX
interaction type: HETERODIMER_ASSOCIATION
right: phosphoSMOX LACK

PUT/ALP23B_ phosphoBABO_SARA/ phosphoSMOX
type: Complex
component stoichiometry: HOMODIMER ID 21STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 51STOICHIOMETRY ID COMPLEX
component stoichiometry: SARA s72 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: SMOX s73 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 32STOICHIOMETRY ID COMPLEX
component: ALP23B
component: PUT
component: SARA
component: SMOX
component: BABO
feature: COMPLEX BINDING FEATURE s77 csa9 64
feature: COMPLEX BINDING FEATURE s77 csa9 70
feature: COMPLEX BINDING FEATURE s77 csa9 62
feature: COMPLEX BINDING FEATURE s77 csa9 66
feature: COMPLEX BINDING FEATURE s77 csa9 68
cellular location: early endosome

SMOX
type: Protein
entity reference: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa26 107
feature: SMOX s38 sa26 rs1
feature: SMOX s38 sa26 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GO GO:0005794 2
type: UnificationXref
id: GO:0005794
db: GO

SMOX s112 sa69 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

SMOX s107 sa75 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR11254:SF395
type: RelationshipXref
id: PTHR11254:SF395
db: PANTHER Family
relationship type: By Homology

MED s98 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

TRANSPORT
type: RelationshipTypeVocabulary

BABO s81 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX s82 sa49 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

BABO
type: Protein
entity reference: BABO
feature: BABO s81 sa11 rs1

ALP23B s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

ALP23B
type: ProteinReference
xref: P06223
standard name: activin like protein at 23B
comment: ENTITY_REFERENCE_ID_DESC=ALP23B_signaling_pathway.PROTEIN.TRUNCATED.ALP23B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dawdle, isoform A

SMOX s107 sa75 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

BABO s44 sa48 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

HOMODIMER ID 40STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 2.0

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s98 sa67 91
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

SMOX s82 sa49 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PUT/ALP23B_ phosphoBABO
type: Complex
component stoichiometry: HOMODIMER ID 18STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 48STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 29STOICHIOMETRY ID COMPLEX
component: BABO
component: PUT
component: ALP23B
feature: COMPLEX BINDING FEATURE s78 csa10 98
feature: COMPLEX BINDING FEATURE s78 csa10 100
feature: COMPLEX BINDING FEATURE s78 csa10 102
cellular location: early endosome

HOMODIMER ID 21STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PPM1A
type: ProteinReference
xref: P06226
standard name: protein phosphatase 2C alpha, beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ALP23B_signaling_pathway.PROTEIN.GENERIC.PPM1A
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Alphabet, isoform E

ALP23B full length s21 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B full length
stoichiometric coefficient: 2.0

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa25 105
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

?
type: Complex
component stoichiometry: ? s31 sa16 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa16 141
cellular location: Golgi apparatus

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa57 87
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

?
type: Complex
component stoichiometry: ? s28 sa18 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa18 137

?
type: Complex
component stoichiometry: ? s25 sa14 STOICHIOMETRY ID COMPLEX
component: ?

ALP23B full length
type: Complex
component stoichiometry: ALP23B full length s21 sa13 STOICHIOMETRY ID COMPLEX
component: ALP23B full length
cellular location: Golgi apparatus

? s28 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

ALP23B
type: Complex
component stoichiometry: ALP23B s80 sa10 STOICHIOMETRY ID COMPLEX
component: ALP23B
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 sa10 95
cellular location: cytosol

BABO s32 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PUT
type: Protein
entity reference: PUT
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

ALP23B
type: Protein
entity reference: ALP23B

BABO s33 sa20 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

PUT s57 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SMOX s89 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 2.0

PUT s10 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

HOMODIMER ID 29STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

HOMODIMER ID 28STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

ALP23B
type: Complex
component stoichiometry: ALP23B s27 sa17 STOICHIOMETRY ID COMPLEX
component: ALP23B
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa17 135

ALP23B
type: Complex
component stoichiometry: ALP23B s13 sa6 STOICHIOMETRY ID COMPLEX
component: ALP23B
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa6 131
cellular location: cytosol

?
type: Protein

ALP23B
type: Complex
component stoichiometry: ALP23B s43 sa47 STOICHIOMETRY ID COMPLEX
component: ALP23B
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa47 101
cellular location: early endosome

ALP23B
type: Complex
component stoichiometry: ALP23B s30 sa15 STOICHIOMETRY ID COMPLEX
component: ALP23B
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa15 139
cellular location: Golgi apparatus

SMOX
type: Complex
component stoichiometry: SMOX s97 sa66 STOICHIOMETRY ID COMPLEX
component: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 sa66 89
cellular location: nucleus

ALP23B
type: Complex
component stoichiometry: ALP23B s4 sa4 STOICHIOMETRY ID COMPLEX
component: ALP23B
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa4 75
cellular location: cytosol

ALP23B
type: Complex
component stoichiometry: ALP23B s1 sa1 STOICHIOMETRY ID COMPLEX
component: ALP23B

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

SMOX s112 sa69 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ALP23B
type: Complex
component stoichiometry: ALP23B s49 sa35 STOICHIOMETRY ID COMPLEX
component: ALP23B
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa35 121
cellular location: early endosome

PARTICIPANT STOICHIOMETRY re26 198
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 199
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

ALP23B
type: Complex
component stoichiometry: ALP23B s58 sa28 STOICHIOMETRY ID COMPLEX
component: ALP23B
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa28 111
cellular location: cytosol

ALP23B
type: Complex
component stoichiometry: ALP23B s70 sa40 STOICHIOMETRY ID COMPLEX
component: ALP23B
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa40 65
cellular location: early endosome

ALP23B s43 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

SMOX s111 sa73 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s99 sa62 rs2
feature: SMOX s99 sa62 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__PUT_ALP23B-_BABO-RIGHT__PUT_ALP23B__BABO-_re1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 177
left: PUT/ALP23B
left: BABO
interaction type: HETERODIMER_ASSOCIATION
right: PUT/ALP23B_ BABO

STATE_TRANSITION_LEFT__ATP-_PUT_ALP23B__phosphoBABO_SARA_SMOX-RIGHT__ADP-_PUT_ALP23B__phosphoBABO_SARA__phosphoSMOX-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 180
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 181
left: ATP
left: PUT/ALP23B_ phosphoBABO_SARA/SMOX
interaction type: STATE_TRANSITION
right: ADP
right: PUT/ALP23B_ phosphoBABO_SARA/ phosphoSMOX

SMOX
type: Complex
component stoichiometry: SMOX s84 sa54 STOICHIOMETRY ID COMPLEX
component: SMOX
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re20 210
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PUT
type: Complex
component stoichiometry: PUT s69 sa39 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa39 63
cellular location: early endosome

PUT
type: Complex
component stoichiometry: PUT s79 sa9 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa9 93
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s48 sa34 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa34 119
cellular location: early endosome

PUT
type: Complex
component stoichiometry: PUT s57 sa27 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa27 109
cellular location: cytosol

ALP23B s4 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

BABO
type: Protein
entity reference: BABO
feature: BABO s44 sa48 rs1

PARTICIPANT STOICHIOMETRY re20 209
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

SMOX s111 sa73 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ALP23B s80 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

SMOX
type: Complex
component stoichiometry: SMOX s89 sa56 STOICHIOMETRY ID COMPLEX
component: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s89 sa56 85
cellular location: cytosol

HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PTHR23255:SF71
type: RelationshipXref
id: PTHR23255:SF71
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re11 190
type: Stoichiometry
physical entity: SARA/SMOX
stoichiometric coefficient: 1.0

PUT
type: Complex
component stoichiometry: PUT s3 sa3 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 73
cellular location: cytosol

STATE_TRANSITION_LEFT__SMOX-_MED-RIGHT__SMOX-_phosphoSMOX__MED-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 159
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 161
left: SMOX
left: MED
interaction type: STATE_TRANSITION
right: SMOX
right: phosphoSMOX/ MED

DISSOCIATION
type: InteractionVocabulary

PUT
type: Complex
component stoichiometry: PUT s12 sa5 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa5 129
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s42 sa46 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa46 99
cellular location: early endosome

PANTHER Pathway P06209 1
type: UnificationXref
id: P06209
db: PANTHER Pathway

ALP23B full length
type: ProteinReference
xref: P06225
standard name: activin like protein at 23B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ALP23B_signaling_pathway.PROTEIN.GENERIC.ALP23B_br_full length
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dawdle, isoform A

PARTICIPANT STOICHIOMETRY re10 192
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re10 191
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

BABO
type: Complex
component stoichiometry: BABO s59 sa29 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa29 113
cellular location: cytosol

SMOX s73 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

BABO
type: Complex
component stoichiometry: BABO s71 sa41 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s71 sa41 67
cellular location: early endosome

BABO
type: Complex
component stoichiometry: BABO s81 sa11 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa11 97
cellular location: cytosol

BABO s44 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PUT
type: Complex
component stoichiometry: PUT s10 sa8 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s34 sa21 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: endoplasmic reticulum

SMOX s107 sa75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 183
type: Stoichiometry
physical entity: PUT/ALP23B_ phosphoBABO_SARA/SMOX
stoichiometric coefficient: 1.0

HOMODIMER ID 52STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re13 184
type: Stoichiometry
physical entity: PUT/ALP23B_ phosphoBABO_SARA/SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 146
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 147
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re11 188
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 189
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

uniprot Q961C5 7
type: UnificationXref
id: Q961C5
db: uniprot

PARTICIPANT STOICHIOMETRY re25 202
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 201
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

BABO
type: Complex
component stoichiometry: BABO s44 sa48 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa48 103
cellular location: early endosome

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoSMOX_LACK-RIGHT__phosphoSMOX_LACK-_re25
controller: LACK

BABO
type: Complex
component stoichiometry: BABO s50 sa36 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa36 123
cellular location: early endosome

BABO
type: Complex
component stoichiometry: BABO s32 sa19 STOICHIOMETRY ID COMPLEX
component: BABO
cellular location: endoplasmic reticulum

BABO
type: Complex
component stoichiometry: BABO s14 sa7 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa7 133
cellular location: cytosol

BABO
type: Complex
component stoichiometry: BABO s5 sa2 STOICHIOMETRY ID COMPLEX
component: BABO
cellular location: cytosol

TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re23
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 204
left: SMOX
interaction type: TRANSPORT
right: SMOX

TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 205
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 206
left: SMOX
interaction type: TRANSPORT
right: SMOX

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s82 sa49 rs2
feature: SMOX s82 sa49 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GO GO:0005783 6
type: UnificationXref
id: GO:0005783
db: GO

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s89 sa56 rs2
feature: SMOX s89 sa56 rs1

HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

Target genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

BABO s50 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__PUT_ALP23B__phosphoBABO_SARA_SMOX-RIGHT__PUT_ALP23B__phosphoBABO_SARA_SMOX-_re13
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 184
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 183
left: PUT/ALP23B_ phosphoBABO_SARA/SMOX
interaction type: TRANSPORT
right: PUT/ALP23B_ phosphoBABO_SARA/SMOX

SARA
type: Protein
entity reference: SARA
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 48STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

HOMODIMER ID 22STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

Dawdle, isoform A
type: ProteinReference
xref: PTHR11848:SF263
xref: uniprot Q9VQG9 42
organism: Drosophila melanogaster

uniprot A0A0B4KG59 23
type: UnificationXref
id: A0A0B4KG59
db: uniprot

MED
type: Protein
entity reference: MED
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 31STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

HOMODIMER ID 17STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX s40 sa24 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

BABO
type: Protein
entity reference: BABO
feature: BABO s71 sa41 rs1

Evidence 24
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0003169.html

uniprot P26016 34
type: UnificationXref
id: P26016
db: uniprot

HOMODIMER ID 20STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re14 180
type: Stoichiometry
physical entity: PUT/ALP23B_ phosphoBABO_SARA/SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 181
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re14 182
type: Stoichiometry
physical entity: PUT/ALP23B_ phosphoBABO_SARA/ phosphoSMOX
stoichiometric coefficient: 1.0

SMOX s40 sa24 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

MED s91 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: uniprot P26016 34
xref: PTHR42884:SF3
organism: Drosophila melanogaster

Evidence 38
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBrf0190369.html

Evidence 36
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0029006.html

PARTICIPANT STOICHIOMETRY re15 172
type: Stoichiometry
physical entity: PUT/ALP23B_ phosphoBABO_SARA/ phosphoSMOX
stoichiometric coefficient: 1.0

SMOX s61 sa31 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re15 173
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 174
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

LACK
type: Protein
entity reference: LACK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re15 175
type: Stoichiometry
physical entity: PUT/ALP23B_ phosphoBABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 179
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 2.0

PUT s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__SMOX-RIGHT__sa76_degraded-_re27
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 196
left: SMOX
interaction type: STATE_TRANSITION
right: sa76_degraded

PARTICIPANT STOICHIOMETRY re3 163
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 10.0

PARTICIPANT STOICHIOMETRY re2 169
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re3 166
type: Stoichiometry
physical entity: PUT/ALP23B_ phosphoBABO
stoichiometric coefficient: 1.0

BABO
type: Protein
entity reference: BABO
feature: BABO s59 sa29 rs1

PARTICIPANT STOICHIOMETRY re3 164
type: Stoichiometry
physical entity: PUT/ALP23B_ BABO
stoichiometric coefficient: 1.0

ALP23B s70 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re3 165
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 10.0

BABO
type: Protein
entity reference: BABO
feature: BABO s33 sa20 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

BABO
type: Protein
entity reference: BABO
feature: BABO s5 sa2 rs1

SMOX s61 sa31 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

ALP23B full length
type: Protein
entity reference: ALP23B full length

BABO s81 sa11 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

HOMODIMER ID 30STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

?
type: Protein

SMOX
type: Protein
entity reference: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s52 sa38 127
feature: SMOX s52 sa38 rs1
feature: SMOX s52 sa38 rs2
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

LACK
type: ProteinReference
xref: P06219
standard name: lethal with a checkpoint kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ALP23B_signaling_pathway.PROTEIN.GENERIC.LACK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: E3 ubiquitin-protein ligase Smurf1

ALP23B s30 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

Evidence 55
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0026369.html

PTHR46319:SF3
type: RelationshipXref
id: PTHR46319:SF3
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re8 144
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re8 145
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re21 208
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 207
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__PUT_ALP23B__phosphoBABO_SARA__phosphoSMOX-RIGHT__SARA-_SMOX-_PUT_ALP23B__phosphoBABO-_re15
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 173
left: PUT/ALP23B_ phosphoBABO_SARA/ phosphoSMOX
interaction type: DISSOCIATION
right: PUT/ALP23B_ phosphoBABO
right: SARA
right: SMOX

TRANSPORT_LEFT__phosphoSMOX__MED-RIGHT__phosphoSMOX__MED-_re21
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 208
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 207
left: phosphoSMOX/ MED
interaction type: TRANSPORT
right: phosphoSMOX/ MED

SMOX
type: Protein
entity reference: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s107 sa75 79
feature: SMOX s107 sa75 rs1
feature: SMOX s107 sa75 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ALP23B
type: Protein
entity reference: ALP23B

STATE_TRANSITION_LEFT__ATP-_PUT_ALP23B__BABO-RIGHT__ADP-_PUT_ALP23B__phosphoBABO-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 166
left: PUT/ALP23B_ BABO
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: PUT/ALP23B_ phosphoBABO

PARTICIPANT STOICHIOMETRY re17 159
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 3.0

SMOX s97 sa66 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

SMOX s89 sa56 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.15

HOMODIMER ID 51STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

HOMODIMER ID 41STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 2.0

PUT/ALP23B_ phosphoBABO_SARA/SMOX
type: Complex
component stoichiometry: SMOX s61 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 31STOICHIOMETRY ID COMPLEX
component stoichiometry: SARA s60 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 20STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 50STOICHIOMETRY ID COMPLEX
component: SARA
component: BABO
component: ALP23B
component: SMOX
component: PUT
feature: COMPLEX BINDING FEATURE s53 csa7 116
feature: COMPLEX BINDING FEATURE s53 csa7 108
feature: COMPLEX BINDING FEATURE s53 csa7 114
feature: COMPLEX BINDING FEATURE s53 csa7 112
feature: COMPLEX BINDING FEATURE s53 csa7 110
cellular location: cytosol

phosphoSMOX/ MED
type: Complex
component stoichiometry: MED s98 sa67 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 41STOICHIOMETRY ID COMPLEX
component: SMOX
component: MED
feature: COMPLEX BINDING FEATURE s96 csa12 88
feature: COMPLEX BINDING FEATURE s96 csa12 90
cellular location: nucleus

STATE_TRANSITION
type: InteractionVocabulary

Zinc finger FYVE domain-containing protein
type: ProteinReference
evidence: Evidence 55
xref: uniprot Q7K9H6 54
xref: PTHR46319:SF3
organism: Drosophila melanogaster

TRANSPORT
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY re16 167
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

TRUNCATION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY re17 161
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 162
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 160
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

SMOX s89 sa56 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re16 168
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 3.0

SMOX
type: ProteinReference
xref: P06224
standard name: Smad on X
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ALP23B_signaling_pathway.PROTEIN.GENERIC.SMOX
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mothers against decapentaplegic homolog

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s112 sa69 rs2
feature: SMOX s112 sa69 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BABO s71 sa41 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

PUT s48 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

BABO s50 sa36 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

PARTICIPANT STOICHIOMETRY re2 170
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re2 171
type: Stoichiometry
physical entity: PUT/ALP23B
stoichiometric coefficient: 1.0

PUT
type: ProteinReference
xref: P06218
standard name: punt
comment: ENTITY_REFERENCE_ID_DESC=ALP23B_signaling_pathway.PROTEIN.RECEPTOR.PUT
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Serine/threonine-protein kinase receptor

E3 ubiquitin-protein ligase Smurf1
type: ProteinReference
evidence: Evidence 36
xref: PTHR11254:SF395
xref: uniprot Q9V853 35
organism: Drosophila melanogaster

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

sa76_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

TRANSPORT_LEFT__MED-RIGHT__MED-_re20
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 210
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 209
left: MED
interaction type: TRANSPORT
right: MED

uniprot P42003 61
type: UnificationXref
id: P42003
db: uniprot

HOMODIMER ID 50STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ALP23B
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__BABO-RIGHT__BABO-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 146
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 147
left: BABO
interaction type: STATE_TRANSITION
right: BABO

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

BABO s14 sa7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

Evidence 13
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0011300.html

PARTICIPANT STOICHIOMETRY re27 197
type: Stoichiometry
physical entity: sa76_degraded
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

SMOX s97 sa66 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Evidence 14
type: Evidence
evidence code: IEA
comment: Website http://www.reactome.org/

PARTICIPANT STOICHIOMETRY re27 196
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

Evidence 10
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0086361.html

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

HETERODIMER_ASSOCIATION_LEFT__SARA-_SMOX-RIGHT__SARA_SMOX-_re11
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 188
left: SMOX
left: SARA
interaction type: HETERODIMER_ASSOCIATION
right: SARA/SMOX

ALP23B
type: Protein
entity reference: ALP23B

ALP23B_signaling_pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__SMOX-_MED-RIGHT__SMOX-_phosphoSMOX__MED-_re17
pathway component: DISSOCIATION_LEFT__phosphoSMOX__MED-RIGHT__SMOX-_MED-_re19
pathway component: STATE_TRANSITION_LEFT__ATP-_PUT_ALP23B__BABO-RIGHT__ADP-_PUT_ALP23B__phosphoBABO-_re3
pathway component: HETERODIMER_ASSOCIATION_LEFT__SMOX-_LACK-RIGHT__phosphoSMOX_LACK-_re28
pathway component: HETERODIMER_ASSOCIATION_LEFT__SARA_SMOX-_PUT_ALP23B__phosphoBABO-RIGHT__PUT_ALP23B__phosphoBABO_SARA_SMOX-_re12
pathway component: DISSOCIATION_LEFT__proALP23B-RIGHT__ALP23B-_?-_re6
pathway component: STATE_TRANSITION_LEFT__phosphoSMOX_LACK-RIGHT__phosphoSMOX_LACK-_re25
pathway component: TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re22
pathway component: HETERODIMER_ASSOCIATION_LEFT__ALP23B-_PUT-RIGHT__PUT_ALP23B-_re2
pathway component: TRANSPORT_LEFT__proALP23B-RIGHT__proALP23B-_re5
pathway component: HETERODIMER_ASSOCIATION_LEFT__PUT_ALP23B-_BABO-RIGHT__PUT_ALP23B__BABO-_re1
pathway component: STATE_TRANSITION_LEFT__BABO-RIGHT__BABO-_re7
pathway component: DISSOCIATION_LEFT__PUT_ALP23B__phosphoBABO_SARA__phosphoSMOX-RIGHT__SARA-_SMOX-_PUT_ALP23B__phosphoBABO-_re15
pathway component: TRUNCATION_LEFT__ALP23B_full_length-RIGHT__?-_ALP23B-_re4
pathway component: TRANSPORT_LEFT__BABO-RIGHT__BABO-_re9
pathway component: TRANSPORT_LEFT__PUT_ALP23B__phosphoBABO_SARA_SMOX-RIGHT__PUT_ALP23B__phosphoBABO_SARA_SMOX-_re13
pathway component: STATE_TRANSITION_LEFT__SMOX-RIGHT__SMOX-_re16
pathway component: HETERODIMER_ASSOCIATION_LEFT__SARA-_SMOX-RIGHT__SARA_SMOX-_re11
pathway component: STATE_TRANSITION_LEFT__SMOX-RIGHT__sa76_degraded-_re27
pathway component: DISSOCIATION_LEFT__phosphoSMOX_LACK-RIGHT__LACK-_SMOX-_re26
pathway component: TRANSPORT_LEFT__phosphoSMOX__MED-RIGHT__phosphoSMOX__MED-_re21
pathway component: TRANSPORT_LEFT__MED-RIGHT__MED-_re20
pathway component: TRANSPORT_LEFT__PUT-RIGHT__PUT-_re10
pathway component: STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re8
pathway component: TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re23
pathway component: STATE_TRANSITION_LEFT__ATP-_PUT_ALP23B__phosphoBABO_SARA_SMOX-RIGHT__ADP-_PUT_ALP23B__phosphoBABO_SARA__phosphoSMOX-_re14
xref: PANTHER Pathway P06209 1
comment: MODEL_NOTES=

SARA
type: Protein
entity reference: SARA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SARA/SMOX
type: Complex
component stoichiometry: SMOX s38 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: SARA s37 sa25 STOICHIOMETRY ID COMPLEX
component: SARA
component: SMOX
feature: COMPLEX BINDING FEATURE s36 csa6 104
feature: COMPLEX BINDING FEATURE s36 csa6 106
cellular location: cytosol

Alphabet, isoform E
type: ProteinReference
evidence: Evidence 10
xref: uniprot Q961C5 7
xref: PTHR47992:SF25
organism: Drosophila melanogaster

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s97 sa66 rs2
feature: SMOX s97 sa66 rs1

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE