PTHR11961:SF12
type: RelationshipXref
id: PTHR11961:SF12
db: PANTHER Family
relationship type: By Homology

uniprot P15999 19
type: UnificationXref
id: P15999
db: uniprot

PTHR10266:SF3
type: RelationshipXref
id: PTHR10266:SF3
db: PANTHER Family
relationship type: By Homology

PTHR11961:SF15
type: RelationshipXref
id: PTHR11961:SF15
db: PANTHER Family
relationship type: By Homology

ATP synthase subunit alpha, mitochondrial
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot P0C522 16
organism: Oryza sativa

ATP synthase subunit alpha
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot A0A1D5QP41 4
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADH-RIGHT__NAD_PLUS_-_H_PLUS_-_r126
controller: FMN FeS

uniprot F7HJS5 60
type: UnificationXref
id: F7HJS5
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

HETERODIMER_ASSOCIATION_LEFT__ATP3_-_Pi_-RIGHT__ATP4_-_re38
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 116
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 117
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 115
left: Pi-
left: ATP3-
interaction type: HETERODIMER_ASSOCIATION
right: ATP4-

ATP synthase subunit alpha
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot W4YP78 34
organism: Strongylocentrotus purpuratus

H+
type: SmallMolecule
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=ION

P02798
type: UnificationXref
id: P02798
db: PANTHER Pathway Component

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 93

P02799
type: UnificationXref
id: P02799
db: PANTHER Pathway Component

uniprot F7CHH8 59
type: UnificationXref
id: F7CHH8
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__ATP3_-RIGHT__ATP3_-_re37
control type: ACTIVATION
controller: Adenine nucleotide transporter

Cytochrome oxidase aa3
type: ProteinReference
xref: P02793
standard name: Cytochrome Oxidase aa3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Cytochromes;
comment: ENTITY_REFERENCE_ID_DESC=ATP synthesis.PROTEIN.GENERIC.Cytochrome_br_oxidase aa_sub_3_endsub_
member entity reference: Quinol oxidase subunit 1
member entity reference: Cytochrome c oxidase subunit 1

F1 beta
type: ProteinReference
xref: P02794
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ATP synthesis.PROTEIN.GENERIC.F_sub_1_endsub_ _beta_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: ATP synthase subunit beta
member entity reference: ATP synthase subunit beta, mitochondrial

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__ATP4_-RIGHT__ATP4_-_re36
control type: ACTIVATION
controller: Adenine nucleotide transporter

uniprot Q03265 28
type: UnificationXref
id: Q03265
db: uniprot

uniprot G1K372 77
type: UnificationXref
id: G1K372
db: uniprot

P02794
type: UnificationXref
id: P02794
db: PANTHER Pathway Component

P02797
type: UnificationXref
id: P02797
db: PANTHER Pathway Component

PTHR11961:SF29
type: RelationshipXref
id: PTHR11961:SF29
db: PANTHER Family
relationship type: By Homology

P02796
type: UnificationXref
id: P02796
db: PANTHER Pathway Component

P02791
type: UnificationXref
id: P02791
db: PANTHER Pathway Component

P02793
type: UnificationXref
id: P02793
db: PANTHER Pathway Component

uniprot Q640U4 89
type: UnificationXref
id: Q640U4
db: uniprot

P02792
type: UnificationXref
id: P02792
db: PANTHER Pathway Component

Chloroplast ATP synthase gamma chain
type: ProteinReference
xref: uniprot A8HXL8 56
xref: PTHR11693:SF23
organism: Chlamydomonas reinhardtii

ATP synthase subunit gamma, mitochondrial
type: ProteinReference
xref: PTHR11693:SF31
xref: uniprot P36542 65
organism: Homo sapiens

Mus musculus
type: BioSource
xref: ncbitaxon 10090 29

ATP synthetase F0
type: Protein
entity reference: ATP synthetase F0
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BU07 73
xref: PTHR11961:SF29
organism: Macaca mulatta

uniprot Q01908 66
type: UnificationXref
id: Q01908
db: uniprot

uniprot F6V9Q4 14
type: UnificationXref
id: F6V9Q4
db: uniprot

STATE_TRANSITION_LEFT__NADH-RIGHT__NAD_PLUS_-_H_PLUS_-_r126
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r126 113
participant stoichiometry: PARTICIPANT STOICHIOMETRY r126 114
participant stoichiometry: PARTICIPANT STOICHIOMETRY r126 112
left: NADH
interaction type: STATE_TRANSITION
right: NAD+
right: H+

uniprot Q9K4D4 68
type: UnificationXref
id: Q9K4D4
db: uniprot

ATP synthase subunit alpha, mitochondrial
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot Q03265 28
organism: Mus musculus

eco ECO:0000304 18
type: UnificationXref
id: ECO:0000304
db: eco

ATP synthase subunit gamma
type: ProteinReference
xref: PTHR11693:SF22
xref: uniprot F6TI82 58
organism: Ornithorhynchus anatinus

ncbitaxon 6669 46
type: UnificationXref
id: 6669
db: ncbitaxon

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 39

uniprot A0A1D5QP41 4
type: UnificationXref
id: A0A1D5QP41
db: uniprot

ATP synthesis
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__ATP3_-_Pi_-RIGHT__ATP4_-_re38
pathway component: TRANSPORT_LEFT__Pi_-RIGHT__Pi_-_re35
pathway component: TRANSPORT_LEFT__ATP3_-RIGHT__ATP3_-_re37
pathway component: TRANSPORT_LEFT__ATP4_-RIGHT__ATP4_-_re36
pathway component: STATE_TRANSITION_LEFT__2H_PLUS___PLUS__1_2O2-RIGHT__H2O-_r133
pathway component: STATE_TRANSITION_LEFT__Succinate-RIGHT__H_PLUS_-_Fumarate-_r127
pathway component: TRANSPORT_LEFT__H_PLUS_-RIGHT__H_PLUS_-_re34
pathway component: STATE_TRANSITION_LEFT__NADH-RIGHT__NAD_PLUS_-_H_PLUS_-_r126
xref: PANTHER Pathway P02721 1
comment: MODEL_NOTES=Panther Pathway: P02721 ATP Synthesis (Oxidative Phosphorylation): ================================= The process responsible for the for mation of ATP from ADP and phosphate in the mitochondria is known as oxidative phosphorylation to distinguish it from the sustrate-level phosphorylation in the glycolytic pathway that can take place in the absence of oxygen. The enrgy required for ATP synthesis in the mitochondria is released by the removal of pairs of hydrogens from a range of substrates including pyruvate, glutamate, and intermediates in the TCA cycle and in the beta-oxidation pathway for fatty acids. These substrate oxidations are coupled to the reduction of the coenzymes NAD+ or FAD in the mitochondrial matrix. The reduced forms of these coenzymes are reoxidized by molecular oxygen using a series of electron carriers on the inner membrane is known as the respiratory chain. References: ========== 1. Human Metabolism by Ramsey Bronk 2. Biochemiscal Pathways - An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal. 3. Color Atlas of Biochemistry by Jan Koolman and Klaus-Heinrich Rohm.

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 55

ATP synthase gamma chain
type: ProteinReference
xref: uniprot P0ABA6 63
xref: PTHR11693:SF22
organism: Escherichia coli

ncbitaxon 7165 93
type: UnificationXref
id: 7165
db: ncbitaxon

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

uniprot Q0DI31 86
type: UnificationXref
id: Q0DI31
db: uniprot

uniprot P62894 82
type: UnificationXref
id: P62894
db: uniprot

Complex (F1 beta/F1 gamma/ F1 beta)
type: Complex
component stoichiometry: F1 beta s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: F1 gamma s2 sa2 STOICHIOMETRY ID COMPLEX
component: F1 gamma
component: F1 beta
feature: COMPLEX BINDING FEATURE s282 a302 99
feature: COMPLEX BINDING FEATURE s282 a302 101
cellular location: mitochondrial matrix

Fumarate
type: SmallMolecule
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=SIMPLE_MOLECULE

UQ UQH2
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa5 106
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P00002 80
type: UnificationXref
id: P00002
db: uniprot

uniprot Q08BA1 30
type: UnificationXref
id: Q08BA1
db: uniprot

ATP synthase subunit alpha, mitochondrial
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot P92549 27
organism: Arabidopsis thaliana

mitochondrial matrix
type: CellularLocationVocabulary
xref: GO GO:0005759 3

uniprot F7BU07 73
type: UnificationXref
id: F7BU07
db: uniprot

ncbitaxon 9544 5
type: UnificationXref
id: 9544
db: ncbitaxon

ncbitaxon 7955 31
type: UnificationXref
id: 7955
db: ncbitaxon

FAD FeS
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa6 108
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=PROTEIN

Cytochrome c-1
type: ProteinReference
xref: uniprot D3ZFQ8 94
xref: PTHR10266:SF3
organism: Rattus norvegicus

uniprot W4YP78 34
type: UnificationXref
id: W4YP78
db: uniprot

uniprot Q6PBF4 91
type: UnificationXref
id: Q6PBF4
db: uniprot

uniprot A0A452DII8 42
type: UnificationXref
id: A0A452DII8
db: uniprot

ATP synthase subunit beta
type: ProteinReference
xref: uniprot H2Q695 50
xref: PTHR15184:SF58
organism: Pan troglodytes

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 13

uniprot P10719 52
type: UnificationXref
id: P10719
db: uniprot

uniprot P05631 62
type: UnificationXref
id: P05631
db: uniprot

Mitochondrial cytochrome c
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot A8J5T0 70
organism: Chlamydomonas reinhardtii

PANTHER Pathway P02721 1
type: UnificationXref
id: P02721
db: PANTHER Pathway

UQ UQH2 s5 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UQ UQH2
stoichiometric coefficient: 1.0

ncbitaxon 9258 15
type: UnificationXref
id: 9258
db: ncbitaxon

Complex (F1 alpha/F1 alpha/ F1 alpha)
type: Complex
component stoichiometry: F1 alpha s7 sa7 STOICHIOMETRY ID COMPLEX
component: F1 alpha
feature: COMPLEX BINDING FEATURE s294 a313 97
cellular location: mitochondrial matrix

mitochondrial outer membrane
type: CellularLocationVocabulary
xref: GO GO:0005741 2

ATP synthase gamma chain 1, chloroplastic
type: ProteinReference
xref: uniprot Q01908 66
xref: PTHR11693:SF23
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r126 112
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

uniprot P62897 83
type: UnificationXref
id: P62897
db: uniprot

ATP synthase subunit beta
type: ProteinReference
xref: uniprot E9FQP0 45
xref: PTHR15184:SF58
organism: Daphnia pulex

uniprot P99999 85
type: UnificationXref
id: P99999
db: uniprot

ncbitaxon 9606 24
type: UnificationXref
id: 9606
db: ncbitaxon

GO GO:0005741 2
type: UnificationXref
id: GO:0005741
db: GO

PARTICIPANT STOICHIOMETRY r126 113
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

uniprot A5A6H5 8
type: UnificationXref
id: A5A6H5
db: uniprot

PARTICIPANT STOICHIOMETRY r126 114
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__2H_PLUS___PLUS__1_2O2-RIGHT__H2O-_r133
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r133 127
participant stoichiometry: PARTICIPANT STOICHIOMETRY r133 126
left: 2H+ + 1/2O2
interaction type: STATE_TRANSITION
right: H2O

ATP synthase subunit beta, mitochondrial
type: ProteinReference
xref: uniprot A0A452DII8 42
xref: PTHR15184:SF58
organism: Bos taurus

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 9

uniprot Q91VR2 67
type: UnificationXref
id: Q91VR2
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 48

PARTICIPANT STOICHIOMETRY re35 122
type: Stoichiometry
physical entity: Pi-
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re35 123
type: Stoichiometry
physical entity: Pi-
stoichiometric coefficient: 1.0

Cytochrome c, somatic
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot Q640U4 89
organism: Xenopus tropicalis

uniprot F7EJM9 74
type: UnificationXref
id: F7EJM9
db: uniprot

ATP synthase subunit gamma, mitochondrial
type: ProteinReference
xref: uniprot Q91VR2 67
xref: PTHR11693:SF22
organism: Mus musculus

H+
type: SmallMolecule
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=ION

uniprot E2RNG2 10
type: UnificationXref
id: E2RNG2
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

ATP synthase subunit alpha, chloroplastic
type: ProteinReference
xref: PTHR48082:SF5
xref: uniprot P56757 25
organism: Arabidopsis thaliana

uniprot P0C522 16
type: UnificationXref
id: P0C522
db: uniprot

ATP synthase subunit beta, mitochondrial
type: ProteinReference
xref: uniprot Q05825 54
xref: PTHR15184:SF58
organism: Drosophila melanogaster

PTHR11410:SF0
type: RelationshipXref
id: PTHR11410:SF0
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re38 116
type: Stoichiometry
physical entity: Pi-
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re38 117
type: Stoichiometry
physical entity: ATP4-
stoichiometric coefficient: 1.0

ncbitaxon 8364 48
type: UnificationXref
id: 8364
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re38 115
type: Stoichiometry
physical entity: ATP3-
stoichiometric coefficient: 1.0

uniprot A8HXL8 56
type: UnificationXref
id: A8HXL8
db: uniprot

ATP synthase subunit beta, mitochondrial
type: ProteinReference
xref: uniprot P56480 53
xref: PTHR15184:SF58
organism: Mus musculus

GO GO:0005759 3
type: UnificationXref
id: GO:0005759
db: GO

F1 gamma
type: Protein
entity reference: F1 gamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 102
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=PROTEIN

F1 alpha s7 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: F1 alpha
stoichiometric coefficient: 3.0

PTHR10422:SF35
type: RelationshipXref
id: PTHR10422:SF35
db: PANTHER Family
relationship type: By Homology

F1 beta
type: Protein
entity reference: F1 beta
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 100
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=PROTEIN

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 24

uniprot D3ZFQ8 94
type: UnificationXref
id: D3ZFQ8
db: uniprot

AGAP009537-PA
type: ProteinReference
xref: uniprot Q7PSA9 92
xref: PTHR11961:SF12
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EJM9 74
xref: PTHR11961:SF12
organism: Ornithorhynchus anatinus

ncbitaxon 559292 39
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot P00401 38
type: UnificationXref
id: P00401
db: uniprot

PTHR10578:SF127
type: RelationshipXref
id: PTHR10578:SF127
db: PANTHER Family
relationship type: By Homology

Pi-
type: SmallMolecule
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=ION

ATP synthase subunit gamma
type: ProteinReference
xref: uniprot H2R2Y8 61
xref: PTHR11693:SF31
organism: Pan troglodytes

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 26

Cytochrome c
type: ProteinReference
xref: uniprot P99999 85
organism: Homo sapiens

PTHR11693:SF31
type: RelationshipXref
id: PTHR11693:SF31
db: PANTHER Family
relationship type: By Homology

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

uniprot A8J5T0 70
type: UnificationXref
id: A8J5T0
db: uniprot

ATP4-
type: SmallMolecule
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 35

Uncharacterized protein
type: ProteinReference
xref: PTHR11961:SF15
xref: uniprot F6STW5 72
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r133 127
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r133 126
type: Stoichiometry
physical entity: 2H+ + 1/2O2
stoichiometric coefficient: 1.0

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 37

Uncharacterized protein
type: ProteinReference
xref: uniprot G1K372 77
xref: PTHR11961:SF29
organism: Macaca mulatta

PTHR11693:SF23
type: RelationshipXref
id: PTHR11693:SF23
db: PANTHER Family
relationship type: By Homology

2H+ + 1/2O2
type: SmallMolecule
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR11693:SF22
type: RelationshipXref
id: PTHR11693:SF22
db: PANTHER Family
relationship type: By Homology

Danio rerio
type: BioSource
xref: ncbitaxon 7955 31

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 64

uniprot A7SPP0 43
type: UnificationXref
id: A7SPP0
db: uniprot

ncbitaxon 39947 17
type: UnificationXref
id: 39947
db: ncbitaxon

ncbitaxon 7668 35
type: UnificationXref
id: 7668
db: ncbitaxon

Succinate
type: SmallMolecule
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TRANSPORT_LEFT__Pi_-RIGHT__Pi_-_re35
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 122
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 123
left: Pi-
interaction type: TRANSPORT
right: Pi-

ncbitaxon 3055 57
type: UnificationXref
id: 3055
db: ncbitaxon

ncbitaxon 83333 64
type: UnificationXref
id: 83333
db: ncbitaxon

ATP synthase subunit alpha, mitochondrial
type: ProteinReference
xref: uniprot P25705 23
xref: PTHR48082:SF3
organism: Homo sapiens

uniprot P00011 81
type: UnificationXref
id: P00011
db: uniprot

ATP synthase subunit alpha
type: ProteinReference
xref: uniprot E2RNG2 10
xref: PTHR48082:SF2
organism: Canis lupus familiaris

Cyt bc1
type: ProteinReference
xref: P02799
standard name: Cytochrome bc1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ATP synthesis.PROTEIN.GENERIC.Cyt bc_sub_1_endsub_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cytochrome c-1
member entity reference: Cytochrome c1, heme protein, mitochondrial

uniprot Q6IQM2 90
type: UnificationXref
id: Q6IQM2
db: uniprot

uniprot F7G769 75
type: UnificationXref
id: F7G769
db: uniprot

uniprot Q9K4D5 32
type: UnificationXref
id: Q9K4D5
db: uniprot

ATP synthase subunit alpha
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot F6V9Q4 14
organism: Ornithorhynchus anatinus

ncbitaxon 13616 13
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot P25705 23
type: UnificationXref
id: P25705
db: uniprot

uniprot P06576 51
type: UnificationXref
id: P06576
db: uniprot

NAD+
type: SmallMolecule
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6STW5 72
type: UnificationXref
id: F6STW5
db: uniprot

TRANSPORT_LEFT__H_PLUS_-RIGHT__H_PLUS_-_re34
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 125
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 124
left: H+
interaction type: TRANSPORT
right: H+

ncbitaxon 45351 44
type: UnificationXref
id: 45351
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Succinate-RIGHT__H_PLUS_-_Fumarate-_r127
controller: Complex (Cyt bc1/UQ UQH2/ FAD FeS)

uniprot P62898 84
type: UnificationXref
id: P62898
db: uniprot

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 41

ncbitaxon 100226 33
type: UnificationXref
id: 100226
db: ncbitaxon

Bos taurus
type: BioSource
xref: ncbitaxon 9913 22

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

ncbitaxon 10090 29
type: UnificationXref
id: 10090
db: ncbitaxon

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 5

uniprot P56480 53
type: UnificationXref
id: P56480
db: uniprot

uniprot Q9D0M3 95
type: UnificationXref
id: Q9D0M3
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 15

uniprot O23138 78
type: UnificationXref
id: O23138
db: uniprot

Cyt C
type: Protein
entity reference: Cyt C
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2H_PLUS___PLUS__1_2O2-RIGHT__H2O-_r133
controller: Cytochrome oxidase aa3

uniprot Q05825 54
type: UnificationXref
id: Q05825
db: uniprot

uniprot P00846 69
type: UnificationXref
id: P00846
db: uniprot

eco ECO:0000303 79
type: UnificationXref
id: ECO:0000303
db: eco

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 96

Complex (Cyt bc1/UQ UQH2/ FAD FeS)
type: Complex
component stoichiometry: UQ UQH2 s5 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: FAD FeS s6 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cyt bc1 s4 sa4 STOICHIOMETRY ID COMPLEX
component: FAD FeS
component: UQ UQH2
component: Cyt bc1
feature: COMPLEX BINDING FEATURE s292 a311 105
feature: COMPLEX BINDING FEATURE s292 a311 103
feature: COMPLEX BINDING FEATURE s292 a311 107
cellular location: mitochondrial outer membrane

uniprot Q0TY36 87
type: UnificationXref
id: Q0TY36
db: uniprot

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 79

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__H_PLUS_-RIGHT__H_PLUS_-_re34
control type: ACTIVATION
controller: Phosphate transporter

FAD FeS s6 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAD FeS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re36 120
type: Stoichiometry
physical entity: ATP4-
stoichiometric coefficient: 1.0

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 18

ncbitaxon 224308 41
type: UnificationXref
id: 224308
db: ncbitaxon

ATP synthase subunit beta
type: ProteinReference
xref: uniprot F7F3I6 49
xref: PTHR15184:SF58
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re36 121
type: Stoichiometry
physical entity: ATP4-
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11961:SF29
xref: uniprot F7G769 75
organism: Macaca mulatta

uniprot P36542 65
type: UnificationXref
id: P36542
db: uniprot

NADH
type: SmallMolecule
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7F3I6 49
type: UnificationXref
id: F7F3I6
db: uniprot

uniprot D4A5L9 71
type: UnificationXref
id: D4A5L9
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 44

F1 alpha
type: ProteinReference
xref: P02791
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ATP synthesis.PROTEIN.GENERIC.F_sub_1_endsub_ _alpha_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: ATP synthase subunit alpha
member entity reference: ATP synthase subunit alpha, mitochondrial
member entity reference: ATP synthase subunit alpha, chloroplastic

ATP synthase subunit a
type: ProteinReference
xref: PTHR11410:SF0
xref: uniprot P00846 69
organism: Homo sapiens

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 20

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__ATP3_-_Pi_-RIGHT__ATP4_-_re38
controller: Complex (F1 beta/F1 gamma/ F1 beta)

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GTP8 76
xref: PTHR11961:SF29
organism: Macaca mulatta

uniprot P92549 27
type: UnificationXref
id: P92549
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 11

ncbitaxon 9913 22
type: UnificationXref
id: 9913
db: ncbitaxon

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 46

ATP synthase subunit gamma, mitochondrial
type: ProteinReference
xref: PTHR11693:SF22
xref: uniprot P05631 62
organism: Bos taurus

ncbitaxon 83332 37
type: UnificationXref
id: 83332
db: ncbitaxon

ATP synthase subunit beta
type: ProteinReference
xref: uniprot F7CKS7 47
xref: PTHR15184:SF58
organism: Xenopus tropicalis

F1 beta s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: F1 beta
stoichiometric coefficient: 2.0

ATP synthetase F0
type: ProteinReference
xref: P02797
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=ATP synthesis.PROTEIN.ION_CHANNEL.ATP_br_synthetase F_sub_0_endsub_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: ATP synthase subunit a

TRANSPORT_LEFT__ATP4_-RIGHT__ATP4_-_re36
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 120
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 121
left: ATP4-
interaction type: TRANSPORT
right: ATP4-

eco ECO:0000501 96
type: UnificationXref
id: ECO:0000501
db: eco

ATP4-
type: SmallMolecule
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TRANSPORT_LEFT__ATP3_-RIGHT__ATP3_-_re37
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 119
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 118
left: ATP3-
interaction type: TRANSPORT
right: ATP3-

ATP synthase subunit alpha, mitochondrial
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot P15999 19
organism: Rattus norvegicus

ATP synthase subunit gamma
type: ProteinReference
xref: PTHR11693:SF22
xref: uniprot F7HJS5 60
organism: Macaca mulatta

ATP3-
type: SmallMolecule
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

FMN FeS
type: Protein
entity reference: FMN FeS
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re37 118
type: Stoichiometry
physical entity: ATP3-
stoichiometric coefficient: 1.0

ATP synthase subunit beta
type: ProteinReference
xref: uniprot A7SPP0 43
xref: PTHR15184:SF58
organism: Nematostella vectensis

PARTICIPANT STOICHIOMETRY re37 119
type: Stoichiometry
physical entity: ATP3-
stoichiometric coefficient: 1.0

ATP synthase subunit beta, mitochondrial
type: ProteinReference
xref: uniprot P10719 52
xref: PTHR15184:SF58
organism: Rattus norvegicus

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 33

Uncharacterized protein
type: ProteinReference
xref: uniprot D4A5L9 71
xref: PTHR11961:SF15
organism: Rattus norvegicus

ATP synthase subunit gamma
type: ProteinReference
xref: PTHR11693:SF22
xref: uniprot F7CHH8 59
organism: Monodelphis domestica

Cytochrome c, testis-specific
type: ProteinReference
xref: uniprot Q6PBF4 91
xref: PTHR11961:SF12
organism: Xenopus tropicalis

Cyt bc1 s4 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cyt bc1
stoichiometric coefficient: 1.0

uniprot H2Q695 50
type: UnificationXref
id: H2Q695
db: uniprot

PARTICIPANT STOICHIOMETRY r127 111
type: Stoichiometry
physical entity: Fumarate
stoichiometric coefficient: 1.0

uniprot P9WND7 36
type: UnificationXref
id: P9WND7
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY r127 110
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 1.0

uniprot F6THT5 12
type: UnificationXref
id: F6THT5
db: uniprot

Phosphate transporter
type: Protein
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=PROTEIN

TRANSPORT
type: InteractionVocabulary

F1 gamma
type: ProteinReference
xref: P02796
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ATP synthesis.PROTEIN.GENERIC.F_sub_1_endsub_ _gamma_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: ATP synthase gamma chain 1, chloroplastic
member entity reference: Chloroplast ATP synthase gamma chain
member entity reference: ATP synthase subunit gamma
member entity reference: ATP synthase subunit gamma, mitochondrial
member entity reference: ATP synthase gamma chain

Cytochrome c
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot Q0DI31 86
organism: Oryza sativa

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 57

Putative mycofactocin system heme/flavin oxidoreductase MftD
type: ProteinReference
xref: PTHR10578:SF127
xref: uniprot P9WND7 36
organism: Mycobacterium tuberculosis

F1 alpha
type: Protein
entity reference: F1 alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa7 98
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=PROTEIN

ATP3-
type: SmallMolecule
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2R2Y8 61
type: UnificationXref
id: H2R2Y8
db: uniprot

Cytochrome c-1
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot O23138 78
organism: Arabidopsis thaliana

ATP synthase subunit alpha, mitochondrial
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot P19483 21
organism: Bos taurus

Pi-
type: SmallMolecule
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=ION

Cytochrome c
type: ProteinReference
xref: PTHR11961:SF15
xref: uniprot P00011 81
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__Succinate-RIGHT__H_PLUS_-_Fumarate-_r127
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 111
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 109
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 110
left: Succinate
interaction type: STATE_TRANSITION
right: Fumarate
right: H+

uniprot F6TI82 58
type: UnificationXref
id: F6TI82
db: uniprot

uniprot Q7PSA9 92
type: UnificationXref
id: Q7PSA9
db: uniprot

F1 gamma s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: F1 gamma
stoichiometric coefficient: 1.0

uniprot E9FQP0 45
type: UnificationXref
id: E9FQP0
db: uniprot

ATP synthase subunit alpha, mitochondrial
type: ProteinReference
xref: uniprot A5A6H5 8
xref: PTHR48082:SF3
organism: Pan troglodytes

uniprot F7CKS7 47
type: UnificationXref
id: F7CKS7
db: uniprot

Cytochrome c oxidase subunit 1
type: ProteinReference
xref: uniprot P00401 38
organism: Saccharomyces cerevisiae

PTHR48082:SF2
type: RelationshipXref
id: PTHR48082:SF2
db: PANTHER Family
relationship type: By Homology

PTHR48082:SF5
type: RelationshipXref
id: PTHR48082:SF5
db: PANTHER Family
relationship type: By Homology

PTHR48082:SF3
type: RelationshipXref
id: PTHR48082:SF3
db: PANTHER Family
relationship type: By Homology

Cyt bc1
type: Protein
entity reference: Cyt bc1
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa4 104
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=PROTEIN

Cytochrome c
type: ProteinReference
xref: uniprot P00002 80
xref: PTHR11961:SF29
organism: Macaca mulatta

FMN FeS
type: ProteinReference
xref: P02792
standard name: Flavin Mononucleotide
comment: ENTITY_REFERENCE_NOTES=Flavin mononucleotide
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ATP synthesis.PROTEIN.GENERIC.FMN_br_FeS
member entity reference: Putative mycofactocin system heme/flavin oxidoreductase MftD

ATP synthase subunit beta, mitochondrial
type: ProteinReference
xref: uniprot P06576 51
xref: PTHR15184:SF58
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot Q0TY36 87
organism: Phaeosphaeria nodorum

uniprot P56757 25
type: UnificationXref
id: P56757
db: uniprot

Cyt C
type: ProteinReference
xref: P02798
standard name: cytochrome c
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=ATP synthesis.PROTEIN.GENERIC.Cyt C
comment: ENTITY_REFERENCE_NOTES=
member entity reference: AGAP009537-PA
member entity reference: Uncharacterized protein
member entity reference: Cytochrome c
member entity reference: Cytochrome c-1
member entity reference: Mitochondrial cytochrome c
member entity reference: Cytochrome c, somatic
member entity reference: Cytochrome c, testis-specific

uniprot P0ABA6 63
type: UnificationXref
id: P0ABA6
db: uniprot

ncbitaxon 9615 11
type: UnificationXref
id: 9615
db: ncbitaxon

Cytochrome c
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot Q6IQM2 90
organism: Danio rerio

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 88

Cytochrome oxidase aa3
type: Protein
entity reference: Cytochrome oxidase aa3
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 321614 88
type: UnificationXref
id: 321614
db: ncbitaxon

PTHR15184:SF58
type: RelationshipXref
id: PTHR15184:SF58
db: PANTHER Family
relationship type: By Homology

ncbitaxon 3702 26
type: UnificationXref
id: 3702
db: ncbitaxon

Adenine nucleotide transporter
type: Protein
cellular location: mitochondrial outer membrane
comment: SPECIES_TYPE=PROTEIN

Quinol oxidase subunit 1
type: ProteinReference
xref: uniprot P34956 40
xref: PTHR10422:SF35
organism: Bacillus subtilis

uniprot P19483 21
type: UnificationXref
id: P19483
db: uniprot

H2O
type: SmallMolecule
cellular location: mitochondrial matrix
comment: SPECIES_TYPE=SIMPLE_MOLECULE

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

ATP synthase subunit alpha
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot F6THT5 12
organism: Monodelphis domestica

ncbitaxon 7227 55
type: UnificationXref
id: 7227
db: ncbitaxon

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9D0M3 95
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re34 125
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 1.0

By Homology
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re34 124
type: Stoichiometry
physical entity: H+
stoichiometric coefficient: 1.0

ncbitaxon 10116 20
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot P34956 40
type: UnificationXref
id: P34956
db: uniprot

uniprot F7GTP8 76
type: UnificationXref
id: F7GTP8
db: uniprot

PARTICIPANT STOICHIOMETRY r127 109
type: Stoichiometry
physical entity: Succinate
stoichiometric coefficient: 1.0

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 17

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Pi_-RIGHT__Pi_-_re35
control type: ACTIVATION
controller: Phosphate transporter

Cytochrome c, somatic
type: ProteinReference
xref: PTHR11961:SF15
xref: uniprot P62898 84
organism: Rattus norvegicus

ATP synthase gamma chain
type: ProteinReference
xref: PTHR11693:SF22
xref: uniprot Q9K4D4 68
organism: Streptomyces coelicolor

Cytochrome c
type: ProteinReference
xref: uniprot P62894 82
xref: PTHR11961:SF15
organism: Bos taurus

ATP synthase subunit alpha
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot Q9K4D5 32
organism: Streptomyces coelicolor

ncbitaxon 9598 9
type: UnificationXref
id: 9598
db: ncbitaxon

Cytochrome c, somatic
type: ProteinReference
xref: uniprot P62897 83
xref: PTHR11961:SF15
organism: Mus musculus

ATP synthase subunit alpha
type: ProteinReference
xref: PTHR48082:SF2
xref: uniprot Q08BA1 30
organism: Danio rerio