SMOX s57 sa31 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

BABO
type: Complex
component stoichiometry: BABO s55 sa29 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa29 110
cellular location: cytosol

HOMODIMER ID 32STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

BABO
type: Complex
component stoichiometry: BABO s70 sa11 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa11 72
cellular location: cytosol

BABO
type: Complex
component stoichiometry: BABO s61 sa41 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa41 92
cellular location: early endosome

BABO
type: Complex
component stoichiometry: BABO s91 sa66 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa66 148
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s5 sa2 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re16 179
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PPM1A
type: ProteinReference
xref: P06237
standard name: protein phosphatase 2C alpha, beta
comment: ENTITY_REFERENCE_ID_DESC=Activinbetasignaling_pathway.PROTEIN.GENERIC.PPM1A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Alphabet, isoform E

PUT
type: Complex
component stoichiometry: PUT s3 sa4 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa4 132
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s31 sa20 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: endoplasmic reticulum

P06236
type: UnificationXref
id: P06236
db: PANTHER Pathway Component

BABO
type: Complex
component stoichiometry: BABO s42 sa48 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa48 78
cellular location: early endosome

BABO
type: Complex
component stoichiometry: BABO s47 sa36 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa36 120
cellular location: early endosome

P06235
type: UnificationXref
id: P06235
db: PANTHER Pathway Component

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

P06233
type: UnificationXref
id: P06233
db: PANTHER Pathway Component

activinbeta s90 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

LACK
type: Protein
entity reference: LACK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GO GO:0005794 2
type: UnificationXref
id: GO:0005794
db: GO

P06239
type: UnificationXref
id: P06239
db: PANTHER Pathway Component

P06238
type: UnificationXref
id: P06238
db: PANTHER Pathway Component

P06237
type: UnificationXref
id: P06237
db: PANTHER Pathway Component

activinbeta full length
type: ProteinReference
xref: P06232
standard name: activin beta
comment: ENTITY_REFERENCE_ID_DESC=Activinbetasignaling_pathway.PROTEIN.GENERIC.activin_beta__br_full length
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Inhibin beta chain

DISSOCIATION_LEFT__PUT_activinbeta_phosphoBABO_SARA_phosphoSMOX-RIGHT__SMOX-_PUT_activinbeta_phosphoBABO-_SARA-_re15
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 184
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 187
left: PUT/activinbeta phosphoBABO SARA/phosphoSMOX
interaction type: DISSOCIATION
right: PUT/activinbeta phosphoBABO
right: SARA
right: SMOX

P06232
type: UnificationXref
id: P06232
db: PANTHER Pathway Component

P06231
type: UnificationXref
id: P06231
db: PANTHER Pathway Component

P06230
type: UnificationXref
id: P06230
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re2 181
type: Stoichiometry
physical entity: PUT/activinbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 182
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re2 183
type: Stoichiometry
physical entity: PUT/activinbeta BABO
stoichiometric coefficient: 1.0

PUT
type: Complex
component stoichiometry: PUT s46 sa34 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa34 116
cellular location: early endosome

PUT
type: Complex
component stoichiometry: PUT s40 sa46 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa46 74
cellular location: early endosome

PUT
type: Complex
component stoichiometry: PUT s89 sa64 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s89 sa64 144
cellular location: cytosol

SARA
type: Protein
entity reference: SARA
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

LACK s103 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

PUT
type: Complex
component stoichiometry: PUT s68 sa9 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa9 68
cellular location: cytosol

PUT s5 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SMOX s73 sa51 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 3.0

PUT
type: Complex
component stoichiometry: PUT s59 sa39 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa39 88
cellular location: early endosome

PUT
type: Complex
component stoichiometry: PUT s53 sa27 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s53 sa27 106
cellular location: cytosol

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s57 sa31 rs1
feature: SMOX s57 sa31 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa31 114
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re12 198
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO
stoichiometric coefficient: 1.0

PUT
type: Complex
component stoichiometry: PUT s8 sa6 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa6 126
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re12 197
type: Stoichiometry
physical entity: SARA/SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 199
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO SARA/SMOX
stoichiometric coefficient: 1.0

SMOX
type: Protein
entity reference: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa43 96
feature: SMOX s63 sa43 rs1
feature: SMOX s63 sa43 rs2
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s103 sa70 98
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

early endosome
type: CellularLocationVocabulary
xref: GO GO:0005769 5

TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re23
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 218
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 219
left: SMOX
interaction type: TRANSPORT
right: SMOX

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 8

FUR1
type: ProteinReference
xref: P06238
standard name: furin 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Activinbetasignaling_pathway.PROTEIN.GENERIC.FUR1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Furin-like protease 1, isoforms 1/1-X/2

PUT
type: Protein
entity reference: PUT

PARTICIPANT STOICHIOMETRY re10 203
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re10 204
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

BABO s6 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 221
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 220
left: SMOX
interaction type: TRANSPORT
right: SMOX

PARTICIPANT STOICHIOMETRY re17 171
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re17 172
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 173
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

BABO s29 sa21 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.45
comment: MODIFICATION_RESIDUE_NAME=

HOMODIMER ID 64STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re17 174
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

HOMODIMER ID 22STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__PUT_activinbeta_phosphoBABO-_PUT_activinbeta_phosphoBABO_DAD-RIGHT__DAD-_re24
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 215
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 216
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 217
left: PUT/activinbeta phosphoBABO DAD
left: PUT/activinbeta phosphoBABO
interaction type: HETERODIMER_ASSOCIATION
right: DAD

STATE_TRANSITION_LEFT__SMOX-_MED-RIGHT__SMOX-_phosphoSMOX__MED-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 172
left: SMOX
left: MED
interaction type: STATE_TRANSITION
right: phosphoSMOX/ MED
right: SMOX

PTHR47992:SF25
type: RelationshipXref
id: PTHR47992:SF25
db: PANTHER Family
relationship type: By Homology

PUT
type: Protein
entity reference: PUT

BABO
type: Complex
component stoichiometry: BABO s10 sa8 STOICHIOMETRY ID COMPLEX
component: BABO
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa8 130
cellular location: cytosol

BABO
type: Complex
component stoichiometry: BABO s29 sa21 STOICHIOMETRY ID COMPLEX
component: BABO
cellular location: endoplasmic reticulum

BABO
type: Complex
component stoichiometry: BABO s6 sa3 STOICHIOMETRY ID COMPLEX
component: BABO
cellular location: cytosol

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 42
xref: uniprot O96660 41
xref: PTHR13703:SF25
organism: Drosophila melanogaster

P06229
type: UnificationXref
id: P06229
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re16 180
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 3.0

HOMODIMER ID 59STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__phosphoSMOX__MED-RIGHT__phosphoSMOX__MED-_re18
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 167
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 166
left: phosphoSMOX/ MED
interaction type: TRANSPORT
right: phosphoSMOX/ MED

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

activinbeta
type: Complex
component stoichiometry: activinbeta s69 sa10 STOICHIOMETRY ID COMPLEX
component: activinbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa10 70
cellular location: cytosol

activinbeta
type: Complex
component stoichiometry: activinbeta s90 sa65 STOICHIOMETRY ID COMPLEX
component: activinbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 sa65 146
cellular location: cytosol

PUT
type: Protein
entity reference: PUT

activinbeta
type: Protein

activinbeta
type: Complex
component stoichiometry: activinbeta s26 sa15 STOICHIOMETRY ID COMPLEX
component: activinbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa15 84
cellular location: Golgi apparatus

activinbeta
type: Complex
component stoichiometry: activinbeta s41 sa47 STOICHIOMETRY ID COMPLEX
component: activinbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa47 76
cellular location: early endosome

SMOX s72 sa50 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

activinbeta
type: Complex
component stoichiometry: activinbeta s45 sa35 STOICHIOMETRY ID COMPLEX
component: activinbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa35 118
cellular location: early endosome

activinbeta
type: Complex
component stoichiometry: activinbeta s54 sa28 STOICHIOMETRY ID COMPLEX
component: activinbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa28 108
cellular location: cytosol

activinbeta
type: Complex
component stoichiometry: activinbeta s60 sa40 STOICHIOMETRY ID COMPLEX
component: activinbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa40 90
cellular location: early endosome

SMOX s104 sa71 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SMOX s74 sa56 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

PUT/activinbeta phosphoBABO SARA/SMOX
type: Complex
component stoichiometry: SARA s56 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 20STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 63STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 32STOICHIOMETRY ID COMPLEX
component stoichiometry: SMOX s57 sa31 STOICHIOMETRY ID COMPLEX
component: BABO
component: activinbeta
component: PUT
component: SARA
component: SMOX
feature: COMPLEX BINDING FEATURE s48 csa7 109
feature: COMPLEX BINDING FEATURE s48 csa7 105
feature: COMPLEX BINDING FEATURE s48 csa7 107
feature: COMPLEX BINDING FEATURE s48 csa7 111
feature: COMPLEX BINDING FEATURE s48 csa7 113
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re6 161
type: Stoichiometry
physical entity: proActivinbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 162
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re6 163
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

activinbeta s41 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

PTHR13703:SF54
type: RelationshipXref
id: PTHR13703:SF54
db: PANTHER Family
relationship type: By Homology

activinbeta
type: Protein

BABO s55 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

BABO s42 sa48 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.45
comment: MODIFICATION_RESIDUE_NAME=

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s33 sa24 rs1
feature: SMOX s33 sa24 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

activinbeta
type: Protein

HOMODIMER ID 66STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re28 207
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 209
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 208
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

activinbeta s45 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

BABO s55 sa29 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.45
comment: MODIFICATION_RESIDUE_NAME=

Target genens
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

activinbeta full length
type: Complex
component stoichiometry: activinbeta full length s16 sa12 STOICHIOMETRY ID COMPLEX
component: activinbeta full length
cellular location: Golgi apparatus

PARTICIPANT STOICHIOMETRY re21 223
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 222
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

SMOX
type: Complex
component stoichiometry: SMOX s73 sa51 STOICHIOMETRY ID COMPLEX
component: SMOX
cellular location: cytosol

SMOX
type: Complex
component stoichiometry: SMOX s79 sa52 STOICHIOMETRY ID COMPLEX
component: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa52 136
cellular location: cytosol

By Homology
type: RelationshipTypeVocabulary

SMOX
type: Complex
component stoichiometry: SMOX s74 sa56 STOICHIOMETRY ID COMPLEX
component: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa56 140
cellular location: nucleus

PARTICIPANT STOICHIOMETRY re4 169
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 2

SMOX
type: Protein
entity reference: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s107 sa75 104
feature: SMOX s107 sa75 rs2
feature: SMOX s107 sa75 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BABO s10 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re4 168
type: Stoichiometry
physical entity: activinbeta full length
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PUT_activinbeta_BABO-RIGHT__ADP-_PUT_activinbeta_phosphoBABO-_re3
controller: PUT

HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

activinbeta
type: Complex
component stoichiometry: activinbeta s9 sa7 STOICHIOMETRY ID COMPLEX
component: activinbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa7 128
cellular location: cytosol

activinbeta
type: Complex
component stoichiometry: activinbeta s23 sa17 STOICHIOMETRY ID COMPLEX
component: activinbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa17 80

PARTICIPANT STOICHIOMETRY re14 191
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO SARA/SMOX
stoichiometric coefficient: 1.0

activinbeta
type: Complex
component stoichiometry: activinbeta s1 sa1 STOICHIOMETRY ID COMPLEX
component: activinbeta

PARTICIPANT STOICHIOMETRY re14 192
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 2.0

activinbeta
type: Complex
component stoichiometry: activinbeta s4 sa5 STOICHIOMETRY ID COMPLEX
component: activinbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa5 134
cellular location: cytosol

activinbeta
type: Protein

MED s77 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

? s27 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__SARA-_SMOX-RIGHT__SARA_SMOX-_re11
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 200
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 202
left: SMOX
left: SARA
interaction type: HETERODIMER_ASSOCIATION
right: SARA/SMOX

?
type: Complex
component stoichiometry: ? s27 sa16 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa16 86
cellular location: Golgi apparatus

HOMODIMER ID 62STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re14 193
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 2.0

SMOX s72 sa50 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

?
type: Complex
component stoichiometry: ? s21 sa14 STOICHIOMETRY ID COMPLEX
component: ?

PARTICIPANT STOICHIOMETRY re14 194
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO SARA/phosphoSMOX
stoichiometric coefficient: 1.0

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 6

?
type: Complex
component stoichiometry: ? s24 sa18 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa18 82

activinbeta full length s16 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta full length
stoichiometric coefficient: 2.0

activinbeta
type: Protein

DISSOCIATION_LEFT__phosphoSMOX__MED-RIGHT__MED-_SMOX-_re20
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 226
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 224
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 225
left: phosphoSMOX/ MED
interaction type: DISSOCIATION
right: MED
right: SMOX

TRUNCATION
type: RelationshipTypeVocabulary

HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 2.0

SMOX s104 sa71 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

PTHR13703:SF25
type: RelationshipXref
id: PTHR13703:SF25
db: PANTHER Family
relationship type: By Homology

activinbeta s23 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

SMOX s104 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 170
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

SARA s43 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

uniprot O96660 41
type: UnificationXref
id: O96660
db: uniprot

HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__SARA_SMOX-_PUT_activinbeta_phosphoBABO-RIGHT__PUT_activinbeta_phosphoBABO_SARA_SMOX-_re12
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 198
left: SARA/SMOX
left: PUT/activinbeta phosphoBABO
interaction type: HETERODIMER_ASSOCIATION
right: PUT/activinbeta phosphoBABO SARA/SMOX

PUT
type: Protein
entity reference: PUT

HETERODIMER_ASSOCIATION_LEFT__PUT_activinbeta-_BABO-RIGHT__PUT_activinbeta_BABO-_re2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 181
left: PUT/activinbeta
left: BABO
interaction type: HETERODIMER_ASSOCIATION
right: PUT/activinbeta BABO

TRANSPORT_LEFT__PUT_activinbeta_phosphoBABO_SARA_SMOX-RIGHT__PUT_activinbeta_phosphoBABO_SARA_SMOX-_re13
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 196
left: PUT/activinbeta phosphoBABO SARA/SMOX
interaction type: TRANSPORT
right: PUT/activinbeta phosphoBABO SARA/SMOX

PARTICIPANT STOICHIOMETRY re7 159
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 1.0

SMOX s49 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

uniprot A1Z7L8 12
type: UnificationXref
id: A1Z7L8
db: uniprot

SMOX s79 sa52 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

DAD s92 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DAD
stoichiometric coefficient: 1.0

eco ECO:0000501 9
type: UnificationXref
id: ECO:0000501
db: eco

SMOX s63 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PUT/activinbeta phosphoBABO
type: Complex
component stoichiometry: HOMODIMER ID 61STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 18STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 30STOICHIOMETRY ID COMPLEX
component: PUT
component: BABO
component: activinbeta
feature: COMPLEX BINDING FEATURE s67 csa10 73
feature: COMPLEX BINDING FEATURE s67 csa10 75
feature: COMPLEX BINDING FEATURE s67 csa10 77
cellular location: early endosome

activinbeta
type: Protein

00696
type: UnificationXref
id: MOD:00696
db: mod

HOMODIMER ID 18STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

phosphoSMOX/ MED
type: Complex
component stoichiometry: HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s77 sa57 STOICHIOMETRY ID COMPLEX
component: MED
component: SMOX
feature: COMPLEX BINDING FEATURE s78 csa12 139
feature: COMPLEX BINDING FEATURE s78 csa12 141
cellular location: nucleus

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa30 112
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

phosphoSMOX/ MED
type: Complex
component stoichiometry: MED s80 sa55 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
component: MED
component: SMOX
feature: COMPLEX BINDING FEATURE s76 csa11 135
feature: COMPLEX BINDING FEATURE s76 csa11 137
cellular location: cytosol

HOMODIMER ID 63STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 9

SMOX s79 sa52 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SMOX s63 sa43 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

? s21 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

SMOX s107 sa75 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

activinbeta
type: Protein

SMOX s38 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PUT/activinbeta phosphoBABO
type: Complex
component stoichiometry: HOMODIMER ID 65STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 22STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 34STOICHIOMETRY ID COMPLEX
component: BABO
component: activinbeta
component: PUT
feature: COMPLEX BINDING FEATURE s15 csa3 69
feature: COMPLEX BINDING FEATURE s15 csa3 67
feature: COMPLEX BINDING FEATURE s15 csa3 71
cellular location: cytosol

HETERODIMER_ASSOCIATION_LEFT__SMOX-_LACK-RIGHT__phosphoSMOX_LACK-_re25
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 214
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 212
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 213
left: LACK
left: SMOX
interaction type: HETERODIMER_ASSOCIATION
right: phosphoSMOX LACK

PTHR23255:SF98
type: RelationshipXref
id: PTHR23255:SF98
db: PANTHER Family
relationship type: By Homology

SMOX
type: Protein
entity reference: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s104 sa71 100
feature: SMOX s104 sa71 rs2
feature: SMOX s104 sa71 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION
type: RelationshipTypeVocabulary

SMOX s63 sa43 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

DAD
type: ProteinReference
xref: P06239
standard name: Daughters against dpp
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Activinbetasignaling_pathway.PROTEIN.GENERIC.DAD
member entity reference: Mothers against decapentaplegic homolog

BABO
type: ProteinReference
xref: P06231
standard name: baboon
comment: ENTITY_REFERENCE_ID_DESC=Activinbetasignaling_pathway.PROTEIN.RECEPTOR.BABO
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

DISSOCIATION_LEFT__proActivinbeta-RIGHT__?-_activinbeta-_re6
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 161
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 163
left: proActivinbeta
interaction type: DISSOCIATION
right: activinbeta
right: ?

SMOX s74 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 2.0

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 sa55 138
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PUT s46 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SMOX s74 sa56 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Protein mothers against dpp
type: ProteinReference
xref: uniprot P42003 55
organism: Drosophila melanogaster

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s85 sa61 rs1
feature: SMOX s85 sa61 rs2
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

LACK s106 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

?
type: Protein

STATE_TRANSITION_LEFT__BABO-RIGHT__BABO-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 159
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 160
left: BABO
interaction type: STATE_TRANSITION
right: BABO

BABO
type: Protein
entity reference: BABO
feature: BABO s55 sa29 rs1

proActivinbeta
type: Complex
component stoichiometry: HOMODIMER ID 60STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 52STOICHIOMETRY ID COMPLEX
component: activinbeta
component: ?
feature: COMPLEX BINDING FEATURE s25 csa4 83
feature: COMPLEX BINDING FEATURE s25 csa4 85
cellular location: Golgi apparatus

SARA s62 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

LACK
type: ProteinReference
xref: P06230
standard name: lethal with a checkpoint kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Activinbetasignaling_pathway.PROTEIN.GENERIC.LACK
member entity reference: E3 ubiquitin-protein ligase Smurf1

DAD
type: Protein
entity reference: DAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa68 150
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 61STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

DISSOCIATION_LEFT__phosphoSMOX_LACK-RIGHT__SMOX-_LACK-_re28
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 207
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 209
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 208
left: phosphoSMOX LACK
interaction type: DISSOCIATION
right: LACK
right: SMOX

PARTICIPANT STOICHIOMETRY re9 155
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re9 156
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re8 158
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re8 157
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 1.0

HOMODIMER ID 28STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

Receptor protein serine/threonine kinase
type: ProteinReference
evidence: Evidence 13
evidence: Evidence 14
xref: PTHR23255:SF71
xref: uniprot A1Z7L8 12
organism: Drosophila melanogaster

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa42 94
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 17STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

PUT s89 sa64 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

HOMODIMER ID 30STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PUT/activinbeta
type: Complex
component stoichiometry: HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 28STOICHIOMETRY ID COMPLEX
component: activinbeta
component: PUT
feature: COMPLEX BINDING FEATURE s2 csa1 133
feature: COMPLEX BINDING FEATURE s2 csa1 131
cellular location: cytosol

?
type: Protein

SMOX s107 sa75 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

BABO
type: Protein
entity reference: BABO
feature: BABO s61 sa41 rs1

SARA
type: ProteinReference
xref: P06235
standard name: Smad anchor for receptor activation
comment: ENTITY_REFERENCE_ID_DESC=Activinbetasignaling_pathway.PROTEIN.RECEPTOR.SARA
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Zinc finger FYVE domain-containing protein

uniprot O61643 46
type: UnificationXref
id: O61643
db: uniprot

PUT/activinbeta BABO
type: Complex
component stoichiometry: HOMODIMER ID 29STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 17STOICHIOMETRY ID COMPLEX
component: BABO
component: PUT
component: activinbeta
feature: COMPLEX BINDING FEATURE s7 csa2 129
feature: COMPLEX BINDING FEATURE s7 csa2 127
feature: COMPLEX BINDING FEATURE s7 csa2 125
cellular location: cytosol

BABO s91 sa66 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.45
comment: MODIFICATION_RESIDUE_NAME=

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s74 sa56 rs2
feature: SMOX s74 sa56 rs1

PUT s31 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 54
xref: PTHR13703:SF45
xref: uniprot O62609 53
organism: Drosophila melanogaster

SMOX s49 sa38 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MED
type: Protein
entity reference: MED
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

BABO s6 sa3 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.45
comment: MODIFICATION_RESIDUE_NAME=

uniprot O62609 53
type: UnificationXref
id: O62609
db: uniprot

activinbeta s9 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re18 166
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 167
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

BABO s30 sa22 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.45
comment: MODIFICATION_RESIDUE_NAME=

Serine/threonine-protein kinase receptor
type: ProteinReference
evidence: Evidence 25
xref: PTHR23255:SF98
xref: uniprot A0A0B4KG59 24
organism: Drosophila melanogaster

PPM1A
type: Protein
entity reference: PPM1A
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Inhibin beta chain
type: ProteinReference
xref: uniprot O61643 46
xref: PTHR11848:SF178
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re7 160
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

BABO
type: Protein
entity reference: BABO
feature: BABO s91 sa66 rs1

SMOX s49 sa38 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

SARA/SMOX
type: Complex
component stoichiometry: SMOX s38 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: SARA s37 sa25 STOICHIOMETRY ID COMPLEX
component: SARA
component: SMOX
feature: COMPLEX BINDING FEATURE s36 csa6 151
feature: COMPLEX BINDING FEATURE s36 csa6 153
cellular location: cytosol

SMOX s57 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

SMOX s79 sa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re13 195
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO SARA/SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 196
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO SARA/SMOX
stoichiometric coefficient: 1.0

GO GO:0005769 5
type: UnificationXref
id: GO:0005769
db: GO

PUT s40 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re20 226
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

SMOX s57 sa31 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re20 224
type: Stoichiometry
physical entity: phosphoSMOX/ MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 225
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

BABO s29 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PUT s53 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s108 sa76 rs1
feature: SMOX s108 sa76 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SMOX s73 sa51 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

BABO
type: Protein
entity reference: BABO
feature: BABO s10 sa8 rs1

PTHR11254:SF395
type: RelationshipXref
id: PTHR11254:SF395
db: PANTHER Family
relationship type: By Homology

uniprot Q5U110 37
type: UnificationXref
id: Q5U110
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

SARA s37 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

PUT/activinbeta phosphoBABO SARA/SMOX
type: Complex
component stoichiometry: HOMODIMER ID 19STOICHIOMETRY ID COMPLEX
component stoichiometry: SMOX s49 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: SARA s43 sa37 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 62STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 31STOICHIOMETRY ID COMPLEX
component: PUT
component: BABO
component: activinbeta
component: SARA
component: SMOX
feature: COMPLEX BINDING FEATURE s52 csa8 119
feature: COMPLEX BINDING FEATURE s52 csa8 121
feature: COMPLEX BINDING FEATURE s52 csa8 115
feature: COMPLEX BINDING FEATURE s52 csa8 117
feature: COMPLEX BINDING FEATURE s52 csa8 123
cellular location: early endosome

HOMODIMER ID 23STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX s108 sa76 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Evidence 38
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0020493.html

PUT
type: ProteinReference
xref: P06229
standard name: punt
comment: ENTITY_REFERENCE_ID_DESC=Activinbetasignaling_pathway.PROTEIN.RECEPTOR.PUT
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Serine/threonine-protein kinase receptor

Evidence 42
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBrf0190369.html

Evidence 40
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0029006.html

SMOX s73 sa51 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

activinbeta s69 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

BABO s10 sa8 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.45
comment: MODIFICATION_RESIDUE_NAME=

activinbeta s54 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s106 sa74 102
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRUNCATION_LEFT__activinbeta_full_length-RIGHT__activinbeta-_?-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 168
left: activinbeta full length
interaction type: TRUNCATION
right: activinbeta
right: ?

PUT
type: Protein
entity reference: PUT

BABO
type: Protein
entity reference: BABO
feature: BABO s42 sa48 rs1

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__phosphoSMOX__MED-RIGHT__MED-_SMOX-_re20
controller: PPM1A

PARTICIPANT STOICHIOMETRY re22 220
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 221
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

SMOX s108 sa76 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

ncbitaxon 7227 8
type: UnificationXref
id: 7227
db: ncbitaxon

Evidence 49
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0026369.html

SMOX
type: Protein
entity reference: SMOX
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa38 124
feature: SMOX s49 sa38 rs2
feature: SMOX s49 sa38 rs1
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

PARTICIPANT STOICHIOMETRY re24 216
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO DAD
stoichiometric coefficient: 1.0

Evidence 10
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0086361.html

PARTICIPANT STOICHIOMETRY re24 215
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 217
type: Stoichiometry
physical entity: DAD
stoichiometric coefficient: 1.0

HOMODIMER ID 51STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re11 200
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 201
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 202
type: Stoichiometry
physical entity: SARA/SMOX
stoichiometric coefficient: 1.0

HOMODIMER ID 60STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

BABO s61 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

Evidence 13
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0011300.html

Evidence 14
type: Evidence
evidence code: IEA
comment: Website http://www.reactome.org/

activinbeta s60 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

phosphoSMOX LACK
type: Complex
component stoichiometry: SMOX s107 sa75 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s106 sa74 STOICHIOMETRY ID COMPLEX
component: LACK
component: SMOX
feature: COMPLEX BINDING FEATURE s105 csa15 101
feature: COMPLEX BINDING FEATURE s105 csa15 103
cellular location: cytosol

TRANSPORT_LEFT__MED-RIGHT__MED-_re21
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 222
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 223
left: MED
interaction type: TRANSPORT
right: MED

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PUT/activinbeta phosphoBABO SARA/phosphoSMOX
type: Complex
component stoichiometry: HOMODIMER ID 64STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 21STOICHIOMETRY ID COMPLEX
component stoichiometry: SMOX s63 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: SARA s62 sa42 STOICHIOMETRY ID COMPLEX
component: SARA
component: activinbeta
component: PUT
component: BABO
component: SMOX
feature: COMPLEX BINDING FEATURE s66 csa9 95
feature: COMPLEX BINDING FEATURE s66 csa9 91
feature: COMPLEX BINDING FEATURE s66 csa9 87
feature: COMPLEX BINDING FEATURE s66 csa9 89
feature: COMPLEX BINDING FEATURE s66 csa9 93
cellular location: early endosome

PUT s3 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__phosphoSMOX_LACK-RIGHT__phosphoSMOX_LACK-_re27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 211
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 210
left: phosphoSMOX LACK
interaction type: STATE_TRANSITION
right: phosphoSMOX LACK

MED
type: ProteinReference
xref: P06233
standard name: medea
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Activinbetasignaling_pathway.PROTEIN.GENERIC.MED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein mothers against dpp
member entity reference: Mothers against decapentaplegic homolog

BABO s70 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re15 185
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 186
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 187
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

Evidence 25
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0003169.html

PUT s8 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re15 184
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO SARA/phosphoSMOX
stoichiometric coefficient: 1.0

BABO s47 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

BABO s42 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PUT_activinbeta_phosphoBABO_SARA_SMOX-_ATP-RIGHT__ADP-_PUT_activinbeta_phosphoBABO_SARA_phosphoSMOX-_re14
controller: BABO

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

PTHR23255:SF71
type: RelationshipXref
id: PTHR23255:SF71
db: PANTHER Family
relationship type: By Homology

BABO s91 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

Target transcripts
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

DISSOCIATION
type: InteractionVocabulary

TRANSPORT_LEFT__proActivinbeta-RIGHT__proActivinbeta-_re5
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 164
left: proActivinbeta
interaction type: TRANSPORT
right: proActivinbeta

FUR1
type: Protein
entity reference: FUR1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

PUT
type: Protein
entity reference: PUT

MED
type: Protein
entity reference: MED
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PUT/activinbeta phosphoBABO DAD
type: Complex
component stoichiometry: HOMODIMER ID 35STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 23STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 66STOICHIOMETRY ID COMPLEX
component stoichiometry: DAD s92 sa68 STOICHIOMETRY ID COMPLEX
component: PUT
component: activinbeta
component: DAD
component: BABO
feature: COMPLEX BINDING FEATURE s93 csa13 143
feature: COMPLEX BINDING FEATURE s93 csa13 149
feature: COMPLEX BINDING FEATURE s93 csa13 145
feature: COMPLEX BINDING FEATURE s93 csa13 147
cellular location: cytosol

HOMODIMER ID 52STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

HOMODIMER ID 34STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__activinbeta_full_length-RIGHT__activinbeta-_?-_re4
controller: FUR1

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

BABO
type: Protein
entity reference: BABO
feature: BABO s70 sa11 rs1

?
type: Protein

SMOX s38 sa26 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

activinbeta s4 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

SMOX s38 sa26 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

PUT
type: Protein
entity reference: PUT

uniprot P42003 55
type: UnificationXref
id: P42003
db: uniprot

PUT
type: Protein
entity reference: PUT
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

PUT
type: Protein
entity reference: PUT

PUT
type: Protein
entity reference: PUT

HOMODIMER ID 35STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PTHR11848:SF178
type: RelationshipXref
id: PTHR11848:SF178
db: PANTHER Family
relationship type: By Homology

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 sa57 142
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__BABO-RIGHT__BABO-_re9
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 156
left: BABO
interaction type: TRANSPORT
right: BABO

BABO
type: Protein
entity reference: BABO
feature: BABO s47 sa36 rs1

HETERODIMER_ASSOCIATION_LEFT__activinbeta-_PUT-RIGHT__PUT_activinbeta-_re1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 188
left: PUT
left: activinbeta
interaction type: HETERODIMER_ASSOCIATION
right: PUT/activinbeta

HOMODIMER ID 29STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PUT s68 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__SMOX-RIGHT__SMOX-_re16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 180
left: SMOX
interaction type: STATE_TRANSITION
right: SMOX

activinbeta full length
type: Protein
entity reference: activinbeta full length

activinbeta s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re23 218
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 219
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 38
xref: PTHR13703:SF54
xref: uniprot Q5U110 37
organism: Drosophila melanogaster

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s79 sa52 rs2
feature: SMOX s79 sa52 rs1

SARA
type: Protein
entity reference: SARA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SMOX s33 sa24 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

BABO
type: Protein
entity reference: BABO
feature: BABO s30 sa22 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: PTHR42884:SF3
xref: uniprot P26016 36
organism: Drosophila melanogaster

activinbeta
type: Protein

SMOX s107 sa75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

? s24 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

proActivinbeta
type: Complex
component stoichiometry: HOMODIMER ID 59STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 51STOICHIOMETRY ID COMPLEX
component: ?
component: activinbeta
feature: COMPLEX BINDING FEATURE s22 csa5 79
feature: COMPLEX BINDING FEATURE s22 csa5 81

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s38 sa26 rs1
feature: SMOX s38 sa26 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa26 154
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SMOX s33 sa24 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__SMOX-RIGHT__sa76_degraded-_re29
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 206
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 205
left: SMOX
interaction type: STATE_TRANSITION
right: sa76_degraded

activinbeta
type: Protein

SMOX
type: ProteinReference
xref: P06236
standard name: Smad on X
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Activinbetasignaling_pathway.PROTEIN.GENERIC.SMOX
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mothers against decapentaplegic homolog

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa37 122
cellular location: early endosome
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 2.0

PUT s59 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

activinbeta s26 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

HOMODIMER ID 19STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

uniprot Q7K9H6 48
type: UnificationXref
id: Q7K9H6
db: uniprot

GO GO:0005783 6
type: UnificationXref
id: GO:0005783
db: GO

HOMODIMER ID 65STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

activinbeta
type: Protein

STATE_TRANSITION_LEFT__ATP-_PUT_activinbeta_BABO-RIGHT__ADP-_PUT_activinbeta_phosphoBABO-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 178
left: ATP
left: PUT/activinbeta BABO
interaction type: STATE_TRANSITION
right: PUT/activinbeta phosphoBABO
right: ADP

PTHR46319:SF3
type: RelationshipXref
id: PTHR46319:SF3
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__PUT-RIGHT__PUT-_re10
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 204
left: PUT
interaction type: TRANSPORT
right: PUT

BABO s70 sa11 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.45
comment: MODIFICATION_RESIDUE_NAME=

BABO s61 sa41 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.45
comment: MODIFICATION_RESIDUE_NAME=

SMOX s85 sa61 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 158
left: PUT
interaction type: STATE_TRANSITION
right: PUT

uniprot Q9V853 39
type: UnificationXref
id: Q9V853
db: uniprot

uniprot Q961C5 7
type: UnificationXref
id: Q961C5
db: uniprot

PARTICIPANT STOICHIOMETRY re1 189
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re1 188
type: Stoichiometry
physical entity: activinbeta
stoichiometric coefficient: 2.0

BABO s47 sa36 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.45
comment: MODIFICATION_RESIDUE_NAME=

PANTHER Pathway P06210 1
type: UnificationXref
id: P06210
db: PANTHER Pathway

STATE_TRANSITION_LEFT__PUT_activinbeta_phosphoBABO_SARA_SMOX-_ATP-RIGHT__ADP-_PUT_activinbeta_phosphoBABO_SARA_phosphoSMOX-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 193
left: PUT/activinbeta phosphoBABO SARA/SMOX
left: ATP
interaction type: STATE_TRANSITION
right: PUT/activinbeta phosphoBABO SARA/phosphoSMOX
right: ADP

SARA
type: Protein
entity reference: SARA
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa25 152
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SARA s56 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SARA
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: InteractionVocabulary

activinbeta
type: Protein

Activinbetasignaling_pathway
type: Pathway
pathway component: TRANSPORT_LEFT__PUT-RIGHT__PUT-_re10
pathway component: STATE_TRANSITION_LEFT__SMOX-RIGHT__SMOX-_re16
pathway component: HETERODIMER_ASSOCIATION_LEFT__SARA-_SMOX-RIGHT__SARA_SMOX-_re11
pathway component: HETERODIMER_ASSOCIATION_LEFT__PUT_activinbeta-_BABO-RIGHT__PUT_activinbeta_BABO-_re2
pathway component: TRUNCATION_LEFT__activinbeta_full_length-RIGHT__activinbeta-_?-_re4
pathway component: HETERODIMER_ASSOCIATION_LEFT__PUT_activinbeta_phosphoBABO-_PUT_activinbeta_phosphoBABO_DAD-RIGHT__DAD-_re24
pathway component: TRANSPORT_LEFT__PUT_activinbeta_phosphoBABO_SARA_SMOX-RIGHT__PUT_activinbeta_phosphoBABO_SARA_SMOX-_re13
pathway component: TRANSPORT_LEFT__MED-RIGHT__MED-_re21
pathway component: TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re23
pathway component: HETERODIMER_ASSOCIATION_LEFT__activinbeta-_PUT-RIGHT__PUT_activinbeta-_re1
pathway component: HETERODIMER_ASSOCIATION_LEFT__SARA_SMOX-_PUT_activinbeta_phosphoBABO-RIGHT__PUT_activinbeta_phosphoBABO_SARA_SMOX-_re12
pathway component: TRANSPORT_LEFT__SMOX-RIGHT__SMOX-_re22
pathway component: DISSOCIATION_LEFT__proActivinbeta-RIGHT__?-_activinbeta-_re6
pathway component: STATE_TRANSITION_LEFT__ATP-_PUT_activinbeta_BABO-RIGHT__ADP-_PUT_activinbeta_phosphoBABO-_re3
pathway component: TRANSPORT_LEFT__BABO-RIGHT__BABO-_re9
pathway component: TRANSPORT_LEFT__proActivinbeta-RIGHT__proActivinbeta-_re5
pathway component: DISSOCIATION_LEFT__phosphoSMOX__MED-RIGHT__MED-_SMOX-_re20
pathway component: TRANSPORT_LEFT__phosphoSMOX__MED-RIGHT__phosphoSMOX__MED-_re18
pathway component: HETERODIMER_ASSOCIATION_LEFT__SMOX-_LACK-RIGHT__phosphoSMOX_LACK-_re25
pathway component: STATE_TRANSITION_LEFT__BABO-RIGHT__BABO-_re7
pathway component: STATE_TRANSITION_LEFT__SMOX-RIGHT__sa76_degraded-_re29
pathway component: DISSOCIATION_LEFT__phosphoSMOX_LACK-RIGHT__SMOX-_LACK-_re28
pathway component: STATE_TRANSITION_LEFT__PUT_activinbeta_phosphoBABO_SARA_SMOX-_ATP-RIGHT__ADP-_PUT_activinbeta_phosphoBABO_SARA_phosphoSMOX-_re14
pathway component: STATE_TRANSITION_LEFT__SMOX-_MED-RIGHT__SMOX-_phosphoSMOX__MED-_re17
pathway component: STATE_TRANSITION_LEFT__phosphoSMOX_LACK-RIGHT__phosphoSMOX_LACK-_re27
pathway component: DISSOCIATION_LEFT__PUT_activinbeta_phosphoBABO_SARA_phosphoSMOX-RIGHT__SMOX-_PUT_activinbeta_phosphoBABO-_SARA-_re15
pathway component: STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re8
xref: PANTHER Pathway P06210 1
comment: MODEL_NOTES=

Zinc finger FYVE domain-containing protein
type: ProteinReference
evidence: Evidence 49
xref: uniprot Q7K9H6 48
xref: PTHR46319:SF3
organism: Drosophila melanogaster

TRANSPORT
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY re1 190
type: Stoichiometry
physical entity: PUT/activinbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 205
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

SMOX s85 sa61 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.67

PARTICIPANT STOICHIOMETRY re29 206
type: Stoichiometry
physical entity: sa76_degraded
stoichiometric coefficient: 1.0

TRUNCATION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY re5 164
type: Stoichiometry
physical entity: proActivinbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 165
type: Stoichiometry
physical entity: proActivinbeta
stoichiometric coefficient: 1.0

DAD
type: Protein
entity reference: DAD
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PUT
type: Protein
entity reference: PUT

HOMODIMER ID 21STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

E3 ubiquitin-protein ligase Smurf1
type: ProteinReference
evidence: Evidence 40
xref: PTHR11254:SF395
xref: uniprot Q9V853 39
organism: Drosophila melanogaster

HOMODIMER ID 31STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

phosphoSMOX LACK
type: Complex
component stoichiometry: LACK s103 sa70 STOICHIOMETRY ID COMPLEX
component stoichiometry: SMOX s104 sa71 STOICHIOMETRY ID COMPLEX
component: LACK
component: SMOX
feature: COMPLEX BINDING FEATURE s97 csa14 99
feature: COMPLEX BINDING FEATURE s97 csa14 97
cellular location: cytosol

BABO
type: Protein
entity reference: BABO
feature: BABO s6 sa3 rs1

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

PARTICIPANT STOICHIOMETRY re3 178
type: Stoichiometry
physical entity: PUT/activinbeta phosphoBABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 177
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 10.0

Evidence 54
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0011655.html

PARTICIPANT STOICHIOMETRY re3 176
type: Stoichiometry
physical entity: PUT/activinbeta BABO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 175
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 10.0

sa76_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

PARTICIPANT STOICHIOMETRY re27 211
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re27 210
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re25 212
type: Stoichiometry
physical entity: SMOX
stoichiometric coefficient: 1.0

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s73 sa51 rs2
feature: SMOX s73 sa51 rs1

uniprot A0A0B4KG59 24
type: UnificationXref
id: A0A0B4KG59
db: uniprot

PARTICIPANT STOICHIOMETRY re25 213
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re25 214
type: Stoichiometry
physical entity: phosphoSMOX LACK
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoSMOX_LACK-RIGHT__phosphoSMOX_LACK-_re27
controller: LACK

BABO
type: Protein
entity reference: BABO
feature: BABO s29 sa21 rs1

uniprot P26016 36
type: UnificationXref
id: P26016
db: uniprot

MED s80 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

HOMODIMER ID 20STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BABO
stoichiometric coefficient: 2.0

SMOX
type: Protein
entity reference: SMOX
feature: SMOX s72 sa50 rs2
feature: SMOX s72 sa50 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Alphabet, isoform E
type: ProteinReference
evidence: Evidence 10
xref: PTHR47992:SF25
xref: uniprot Q961C5 7
organism: Drosophila melanogaster