deoxyinosine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9W719 78
type: UnificationXref
id: Q9W719
db: uniprot

Adenine phosphoribosyltransferase 5
type: ProteinReference
xref: uniprot Q9LFP0 152
organism: Arabidopsis thaliana

Protein CBG05749
type: ProteinReference
xref: uniprot A8X1Q6 84
organism: Caenorhabditis briggsae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRPP-_adenine-RIGHT__AMP-_PPi-_r8
controller: Adenine phosphoribosyl transferase

PARTICIPANT STOICHIOMETRY r3 163
type: Stoichiometry
physical entity: IMP
stoichiometric coefficient: 1.0

uniprot F6ZX14 110
type: UnificationXref
id: F6ZX14
db: uniprot

Giardia intestinalis
type: BioSource
xref: ncbitaxon 184922 129

PARTICIPANT STOICHIOMETRY r3 162
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P73935 142
organism: Synechocystis

PARTICIPANT STOICHIOMETRY r3 161
type: Stoichiometry
physical entity: inosine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 164
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot O42842 133
type: UnificationXref
id: O42842
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_adenosine-RIGHT__NH3-_inosine-_r2
controller: Adenosine deaminase

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot E2RTW6 128
organism: Giardia intestinalis

Mus musculus
type: BioSource
xref: ncbitaxon 10090 19

uniprot P00492 52
type: UnificationXref
id: P00492
db: uniprot

Adenosine deaminase
type: ProteinReference
xref: uniprot P63907 93
organism: Mycobacterium tuberculosis

uniprot Q6WIT9 64
type: UnificationXref
id: Q6WIT9
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9X8I5 81
organism: Streptomyces coelicolor

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 25

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 15

ncbitaxon 1111708 143
type: UnificationXref
id: 1111708
db: ncbitaxon

Adenine phosphoribosyltransferase 2
type: ProteinReference
xref: uniprot Q42563 147
organism: Arabidopsis thaliana

uniprot P37472 55
type: UnificationXref
id: P37472
db: uniprot

PTHR11908:SF130
type: RelationshipXref
id: PTHR11908:SF130
db: PANTHER Family
relationship type: By Homology

uniprot P42085 139
type: UnificationXref
id: P42085
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__deoxyinosine-_NH3-RIGHT__deoxyadenosine-_H2O-_r6
controller: Deoxyadenosine deaminase

uniprot A8XI15 8
type: UnificationXref
id: A8XI15
db: uniprot

uniprot Q04633 146
type: UnificationXref
id: Q04633
db: uniprot

Adenine deaminase
type: ProteinReference
xref: uniprot P53909 91
organism: Saccharomyces cerevisiae

ncbitaxon 243230 77
type: UnificationXref
id: 243230
db: ncbitaxon

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A8XWA1 41
organism: Caenorhabditis briggsae

STATE_TRANSITION_LEFT__deoxyinosine-_NH3-RIGHT__deoxyadenosine-_H2O-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 200
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 198
left: NH3
left: deoxyinosine
interaction type: STATE_TRANSITION
right: deoxyadenosine
right: H2O

NAD
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Adenosine deaminase
type: ProteinReference
xref: P02811
comment: ENTITY_REFERENCE_ID_DESC=Adenine and hypoxanthine salvage pathway.PROTEIN.GENERIC.Adenosine_br_deaminase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Adenosine deaminase
member entity reference: Adenine deaminase
member entity reference: ACEtyl-CoA Regulator
member entity reference: Adenosine deaminase 1
member entity reference: Uncharacterized protein
member entity reference: Aminodeoxyfutalosine deaminase
member entity reference: Adenosine deaminase-like protein
member entity reference: AGAP005158-PA
member entity reference: Protein CBG05749
member entity reference: Adenosine deaminase 2
member entity reference: Putative adenosine/adenine deaminase
member entity reference: Uncharacterized deaminase C1683.02

Uncharacterized protein
type: ProteinReference
xref: uniprot F6T5C3 130
organism: Macaca mulatta

uniprot Q9I6Y4 101
type: UnificationXref
id: Q9I6Y4
db: uniprot

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 69

uniprot Q18599 94
type: UnificationXref
id: Q18599
db: uniprot

uniprot H2QBQ7 131
type: UnificationXref
id: H2QBQ7
db: uniprot

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P12426 136
organism: Drosophila melanogaster

ncbitaxon 559292 25
type: UnificationXref
id: 559292
db: ncbitaxon

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot F6YAY4 46
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r12 182
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 183
type: Stoichiometry
physical entity: hypoxanthine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 184
type: Stoichiometry
physical entity: 2 H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 185
type: Stoichiometry
physical entity: xanthine
stoichiometric coefficient: 1.0

Deoxyinosine phosphorylase
type: Protein
entity reference: Deoxyinosine phosphorylase
comment: SPECIES_TYPE=PROTEIN

uniprot P9WHQ9 56
type: UnificationXref
id: P9WHQ9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11908:SF80
xref: uniprot F6ZX14 110
organism: Macaca mulatta

Purine nucleoside phosphorylase
type: ProteinReference
xref: PTHR11904:SF12
xref: uniprot P23492 18
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__hypoxanthine-_PRPP-RIGHT__IMP-_PPi-_r14
controller: Hypoxanthine phosphoribosyl transferase

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q9X259 33
organism: Thermotoga maritima

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q9X1T2 31
organism: Thermotoga maritima

uniprot Q9X1A4 156
type: UnificationXref
id: Q9X1A4
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 13

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot F4IA25 44
organism: Arabidopsis thaliana

ncbitaxon 185431 58
type: UnificationXref
id: 185431
db: ncbitaxon

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: PTHR11908:SF80
xref: uniprot P22985 115
organism: Rattus norvegicus

Inosine phosphorylase
type: Protein
entity reference: Inosine phosphorylase
comment: SPECIES_TYPE=PROTEIN

APRT isoform 1
type: ProteinReference
xref: uniprot H2QBQ7 131
organism: Pan troglodytes

uniprot Q9I3J0 124
type: UnificationXref
id: Q9I3J0
db: uniprot

uniprot P47990 117
type: UnificationXref
id: P47990
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__inosine-_ATP-RIGHT__IMP-_ADP-_r3
controller: Inosine kinase

uniprot A0A452DJA8 2
type: UnificationXref
id: A0A452DJA8
db: uniprot

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P08030 135
organism: Mus musculus

By Homology
type: RelationshipTypeVocabulary

uniprot Q9SUW2 155
type: UnificationXref
id: Q9SUW2
db: uniprot

uniprot A0A1D5QEF0 82
type: UnificationXref
id: A0A1D5QEF0
db: uniprot

uniprot P12426 136
type: UnificationXref
id: P12426
db: uniprot

uniprot U4PSA1 34
type: UnificationXref
id: U4PSA1
db: uniprot

urate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8RGK5 70
organism: Fusobacterium nucleatum

uniprot Q9P6J8 104
type: UnificationXref
id: Q9P6J8
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9RUK8 76
organism: Deinococcus radiodurans

STATE_TRANSITION_LEFT__H2O-_hypoxanthine-RIGHT__2_H_PLUS_-_xanthine-_r12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 184
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 183
left: hypoxanthine
left: H2O
interaction type: STATE_TRANSITION
right: xanthine
right: 2 H+

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_xanthine-_NAD-RIGHT__NADH-_urate-_r13
controller: Xanthine dehydrogenase

Adenosine deaminase
type: ProteinReference
xref: uniprot P03958 88
organism: Mus musculus

Protein CBG14916
type: ProteinReference
xref: uniprot A8XKZ6 127
organism: Caenorhabditis briggsae

STATE_TRANSITION_LEFT__ribose_1_phosphate-_adenine-RIGHT__PO4-_adenosine-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 172
left: adenine
left: ribose-1-phosphate
interaction type: STATE_TRANSITION
right: PO4
right: adenosine

uniprot P22333 89
type: UnificationXref
id: P22333
db: uniprot

uniprot Q4QCC2 61
type: UnificationXref
id: Q4QCC2
db: uniprot

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot O66821 50
organism: Aquifex aeolicus

uniprot Q80SY6 96
type: UnificationXref
id: Q80SY6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ribose_1_phosphate-_adenine-RIGHT__PO4-_adenosine-_r1
controller: Adenine phosphorylase

uniprot A8Y084 108
type: UnificationXref
id: A8Y084
db: uniprot

PARTICIPANT STOICHIOMETRY r1 172
type: Stoichiometry
physical entity: adenosine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 171
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 170
type: Stoichiometry
physical entity: adenine
stoichiometric coefficient: 1.0

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9WY49 80
organism: Thermotoga maritima

uniprot P80457 118
type: UnificationXref
id: P80457
db: uniprot

Xanthine dehydrogenase 2
type: ProteinReference
xref: uniprot F4JLI5 109
organism: Arabidopsis thaliana

Xanthine dehydrogenase, C-terminal subunit
type: ProteinReference
xref: uniprot Q9RYX6 125
organism: Deinococcus radiodurans

NADH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P02810
type: UnificationXref
id: P02810
db: PANTHER Pathway Component

P02811
type: UnificationXref
id: P02811
db: PANTHER Pathway Component

P02812
type: UnificationXref
id: P02812
db: PANTHER Pathway Component

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot G3N0T0 49
organism: Bos taurus

P02813
type: UnificationXref
id: P02813
db: PANTHER Pathway Component

ncbitaxon 190304 71
type: UnificationXref
id: 190304
db: ncbitaxon

ncbitaxon 227321 98
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q9SU38 154
type: UnificationXref
id: Q9SU38
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q38C93 57
organism: Trypanosoma brucei

Putative dehydrogenase
type: ProteinReference
xref: uniprot Q9EWG8 123
organism: Streptomyces coelicolor

uniprot A4Q998 6
type: UnificationXref
id: A4Q998
db: uniprot

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q3SZ18 60
organism: Bos taurus

adenine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O86737 86
type: UnificationXref
id: O86737
db: uniprot

xanthine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P9WP01 22
type: UnificationXref
id: P9WP01
db: uniprot

ncbitaxon 9606 17
type: UnificationXref
id: 9606
db: ncbitaxon

P02808
type: UnificationXref
id: P02808
db: PANTHER Pathway Component

P02809
type: UnificationXref
id: P02809
db: PANTHER Pathway Component

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 21

P02807
type: UnificationXref
id: P02807
db: PANTHER Pathway Component

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P07741 134
organism: Homo sapiens

uniprot Q9RYX6 125
type: UnificationXref
id: Q9RYX6
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 3

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 11

P02804
type: UnificationXref
id: P02804
db: PANTHER Pathway Component

P02805
type: UnificationXref
id: P02805
db: PANTHER Pathway Component

Adenine phosphorylase
type: ProteinReference
xref: P02805
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Adenine and hypoxanthine salvage pathway.PROTEIN.GENERIC.Adenine_br_phosphorylase
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Purine nucleoside phosphorylase 1
member entity reference: Purine nucleoside phosphorylase
member entity reference: Putative purine nucleoside phosphorylase
member entity reference: AGAP005945-PA
member entity reference: Uncharacterized protein, isoform H

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 48

Protein CBG21624
type: ProteinReference
xref: uniprot A8Y084 108
organism: Caenorhabditis briggsae

uniprot A8XWA1 41
type: UnificationXref
id: A8XWA1
db: uniprot

ncbitaxon 9258 48
type: UnificationXref
id: 9258
db: ncbitaxon

Xanthine dehydrogenase
type: ProteinReference
xref: PTHR11908:SF80
xref: uniprot H2QHQ2 111
organism: Pan troglodytes

ncbitaxon 284812 30
type: UnificationXref
id: 284812
db: ncbitaxon

ncbitaxon 6238 9
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot Q9L0L6 102
type: UnificationXref
id: Q9L0L6
db: uniprot

ncbitaxon 224324 51
type: UnificationXref
id: 224324
db: ncbitaxon

Xanthine DeHydrogenase homolog
type: ProteinReference
xref: uniprot O17892 112
organism: Caenorhabditis elegans

ncbitaxon 10090 19
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot F6YAY4 46
type: UnificationXref
id: F6YAY4
db: uniprot

ncbitaxon 9544 11
type: UnificationXref
id: 9544
db: ncbitaxon

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot O42842 133
organism: Schizosaccharomyces pombe

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q89ZJ1 66
organism: Bacteroides thetaiotaomicron

uniprot Q9RUK8 76
type: UnificationXref
id: Q9RUK8
db: uniprot

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 51

Hypoxanthine phosphoribosyl transferase
type: ProteinReference
xref: P02804
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Adenine and hypoxanthine salvage pathway.PROTEIN.GENERIC.Hypoxanthine_br_phosphoribosyl_br_transferase
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Hypoxanthine phosphoribosyltransferase
member entity reference: Hypoxanthine-guanine phosphoribosyltransferase
member entity reference: Probable purine/pyrimidine phosphoribosyl transferase
member entity reference: Xanthine phosphoribosyltransferase
member entity reference: Phosphoribosyltransferase domain-containing protein 1

uniprot A0A1D5RJY6 36
type: UnificationXref
id: A0A1D5RJY6
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 65

uniprot Q8GUQ8 121
type: UnificationXref
id: Q8GUQ8
db: uniprot

uniprot Q9NF11 74
type: UnificationXref
id: Q9NF11
db: uniprot

uniprot O61198 113
type: UnificationXref
id: O61198
db: uniprot

PARTICIPANT STOICHIOMETRY r8 190
type: Stoichiometry
physical entity: PRPP
stoichiometric coefficient: 1.0

Xanthine dehydrogenase
type: ProteinReference
xref: uniprot Q9I3J0 124
organism: Pseudomonas aeruginosa

PARTICIPANT STOICHIOMETRY r8 191
type: Stoichiometry
physical entity: adenine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 192
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 193
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

uniprot H2Q7W4 12
type: UnificationXref
id: H2Q7W4
db: uniprot

ncbitaxon 224308 21
type: UnificationXref
id: 224308
db: ncbitaxon

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 79

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot F7AT83 47
organism: Ornithorhynchus anatinus

ncbitaxon 9598 13
type: UnificationXref
id: 9598
db: ncbitaxon

Xanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9HTQ6 151
organism: Pseudomonas aeruginosa

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 28

Xanthine dehydrogenase
type: ProteinReference
xref: P02809
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Adenine and hypoxanthine salvage pathway.PROTEIN.GENERIC.Xanthine_br_dehydrogenase
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Xanthine dehydrogenase, C-terminal subunit
member entity reference: Xanthine dehydrogenase/oxidase
member entity reference: Xanthine dehydrogenase 2
member entity reference: Xanthine dehydrogenase
member entity reference: Xanthine dehydrogenase 1
member entity reference: Putative dehydrogenase
member entity reference: Probable aldehyde oxidase gad-3
member entity reference: Protein CBG21624
member entity reference: Xanthine DeHydrogenase homolog

uniprot A0A452DIE3 126
type: UnificationXref
id: A0A452DIE3
db: uniprot

deoxyribose-1-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r5 158
type: Stoichiometry
physical entity: hypoxanthine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 157
type: Stoichiometry
physical entity: deoxyribose-1-phosphate
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q9X259 33
type: UnificationXref
id: Q9X259
db: uniprot

STATE_TRANSITION_LEFT__H2O-_xanthine-_NAD-RIGHT__NADH-_urate-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 180
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 181
left: NAD
left: xanthine
left: H2O
interaction type: STATE_TRANSITION
right: NADH
right: urate

PARTICIPANT STOICHIOMETRY r5 159
type: Stoichiometry
physical entity: deoxyinosine
stoichiometric coefficient: 1.0

uniprot M9PE19 14
type: UnificationXref
id: M9PE19
db: uniprot

PARTICIPANT STOICHIOMETRY r5 160
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

uniprot Q05788 24
type: UnificationXref
id: Q05788
db: uniprot

Adenosine deaminase
type: ProteinReference
xref: uniprot A0A2I3SA16 83
organism: Pan troglodytes

ncbitaxon 184922 129
type: UnificationXref
id: 184922
db: ncbitaxon

Adenine phosphoribosyltransferase 1
type: ProteinReference
xref: uniprot P49435 140
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r6 201
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 200
type: Stoichiometry
physical entity: deoxyadenosine
stoichiometric coefficient: 1.0

Putative purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q9UTG1 29
organism: Schizosaccharomyces pombe

Phosphoribosyltransferase domain-containing protein 1
type: ProteinReference
xref: uniprot Q9NRG1 75
organism: Homo sapiens

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A0A2R8QRE7 38
organism: Danio rerio

uniprot O17892 112
type: UnificationXref
id: O17892
db: uniprot

uniprot P00491 16
type: UnificationXref
id: P00491
db: uniprot

uniprot A0A2I3TEX9 37
type: UnificationXref
id: A0A2I3TEX9
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot B2RYS6 42
organism: Rattus norvegicus

uniprot Q3SZ18 60
type: UnificationXref
id: Q3SZ18
db: uniprot

uniprot Q9LFP0 152
type: UnificationXref
id: Q9LFP0
db: uniprot

uniprot E2RTW6 128
type: UnificationXref
id: E2RTW6
db: uniprot

uniprot F4IA25 44
type: UnificationXref
id: F4IA25
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 9

Xanthine dehydrogenase
type: ProteinReference
xref: uniprot Q12553 120
xref: PTHR11908:SF130
organism: Emericella nidulans

AMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Purine nucleoside phosphorylase 1
type: ProteinReference
xref: uniprot P46354 20
organism: Bacillus subtilis

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 35

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q4Q9H8 148
organism: Leishmania major

Inosine kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: PTHR11908:SF80
xref: uniprot P47989 116
organism: Homo sapiens

PANTHER Pathway P02723 1
type: UnificationXref
id: P02723
db: PANTHER Pathway

uniprot P63907 93
type: UnificationXref
id: P63907
db: uniprot

Adenosine deaminase
type: ProteinReference
xref: uniprot P00813 87
organism: Homo sapiens

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: PTHR11908:SF80
xref: uniprot P47990 117
organism: Gallus gallus

uniprot Q8RDM9 150
type: UnificationXref
id: Q8RDM9
db: uniprot

PARTICIPANT STOICHIOMETRY r6 199
type: Stoichiometry
physical entity: NH3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 198
type: Stoichiometry
physical entity: deoxyinosine
stoichiometric coefficient: 1.0

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9W719 78
organism: Gallus gallus

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A0A1D5RJY6 36
organism: Macaca mulatta

PTHR11908:SF100
type: RelationshipXref
id: PTHR11908:SF100
db: PANTHER Family
relationship type: By Homology

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 73

uniprot Q9VHH7 106
type: UnificationXref
id: Q9VHH7
db: uniprot

Putative adenosine/adenine deaminase
type: ProteinReference
xref: uniprot Q9L0L6 102
organism: Streptomyces coelicolor

PARTICIPANT STOICHIOMETRY r2 166
type: Stoichiometry
physical entity: adenosine
stoichiometric coefficient: 1.0

uniprot H2QHQ2 111
type: UnificationXref
id: H2QHQ2
db: uniprot

PARTICIPANT STOICHIOMETRY r2 165
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 168
type: Stoichiometry
physical entity: inosine
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__deoxyribose_1_phosphate-_hypoxanthine-RIGHT__deoxyinosine-_PO4-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 159
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 157
left: deoxyribose-1-phosphate
left: hypoxanthine
interaction type: STATE_TRANSITION
right: PO4
right: deoxyinosine

PARTICIPANT STOICHIOMETRY r2 167
type: Stoichiometry
physical entity: NH3
stoichiometric coefficient: 1.0

ncbitaxon 226186 67
type: UnificationXref
id: 226186
db: ncbitaxon

uniprot P10351 114
type: UnificationXref
id: P10351
db: uniprot

Adenosine deaminase
type: ProteinReference
xref: uniprot P22333 89
organism: Escherichia coli

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q9D8C9 26
xref: PTHR11904:SF12
organism: Mus musculus

uniprot P08030 135
type: UnificationXref
id: P08030
db: uniprot

uniprot P56658 92
type: UnificationXref
id: P56658
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 7

PARTICIPANT STOICHIOMETRY r13 177
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot G3N0T0 49
type: UnificationXref
id: G3N0T0
db: uniprot

PARTICIPANT STOICHIOMETRY r13 178
type: Stoichiometry
physical entity: xanthine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 179
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

deoxyadenosine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Adenosine deaminase 1
type: ProteinReference
xref: uniprot Q9AK25 100
organism: Streptomyces coelicolor

uniprot Q9RTY2 153
type: UnificationXref
id: Q9RTY2
db: uniprot

ncbitaxon 36329 69
type: UnificationXref
id: 36329
db: ncbitaxon

Xanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q4QCC2 61
organism: Leishmania major

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q4QCC3 63
organism: Leishmania major

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 32

uniprot Q00519 119
type: UnificationXref
id: Q00519
db: uniprot

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P52561 141
organism: Streptomyces coelicolor

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r13 180
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

uniprot Q38C93 57
type: UnificationXref
id: Q38C93
db: uniprot

PARTICIPANT STOICHIOMETRY r13 181
type: Stoichiometry
physical entity: urate
stoichiometric coefficient: 1.0

uniprot Q9X8I5 81
type: UnificationXref
id: Q9X8I5
db: uniprot

Deoxyadenosine phosphorylase
type: Protein
entity reference: Deoxyadenosine phosphorylase
comment: SPECIES_TYPE=PROTEIN

uniprot P36973 138
type: UnificationXref
id: P36973
db: uniprot

uniprot Q7Q6Q8 149
type: UnificationXref
id: Q7Q6Q8
db: uniprot

uniprot P73935 142
type: UnificationXref
id: P73935
db: uniprot

uniprot A5A6I1 40
type: UnificationXref
id: A5A6I1
db: uniprot

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 143

Adenine and hypoxanthine salvage pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__deoxyinosine-_NH3-RIGHT__deoxyadenosine-_H2O-_r6
pathway component: STATE_TRANSITION_LEFT__inosine-_ATP-RIGHT__IMP-_ADP-_r3
pathway component: STATE_TRANSITION_LEFT__deoxyadenosine-_PO4-RIGHT__deoxyribose_1_phosphate-_adenine-_r7
pathway component: STATE_TRANSITION_LEFT__hypoxanthine-_PRPP-RIGHT__IMP-_PPi-_r14
pathway component: STATE_TRANSITION_LEFT__H2O-_xanthine-_NAD-RIGHT__NADH-_urate-_r13
pathway component: STATE_TRANSITION_LEFT__H2O-_adenosine-RIGHT__NH3-_inosine-_r2
pathway component: STATE_TRANSITION_LEFT__ribose_1_phosphate-_adenine-RIGHT__PO4-_adenosine-_r1
pathway component: STATE_TRANSITION_LEFT__deoxyribose_1_phosphate-_hypoxanthine-RIGHT__deoxyinosine-_PO4-_r5
pathway component: STATE_TRANSITION_LEFT__PRPP-_adenine-RIGHT__AMP-_PPi-_r8
pathway component: STATE_TRANSITION_LEFT__H2O-_hypoxanthine-RIGHT__2_H_PLUS_-_xanthine-_r12
pathway component: STATE_TRANSITION_LEFT__PO4-_inosine-RIGHT__hypoxanthine-_ribose_1_phosphate-_r11
pathway component: KNOWN_TRANSITION_OMITTED
xref: PANTHER Pathway P02723 1
comment: MODEL_NOTES=The prokaryote salvage (recycle) pathway for purine nucleosides adenine and hypoxanthine. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

Xanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P42085 139
organism: Bacillus subtilis

ncbitaxon 208964 73
type: UnificationXref
id: 208964
db: ncbitaxon

uniprot Q38CA0 59
type: UnificationXref
id: Q38CA0
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

Adenine phosphorylase
type: Protein
entity reference: Adenine phosphorylase
comment: SPECIES_TYPE=PROTEIN

PTHR11904:SF12
type: RelationshipXref
id: PTHR11904:SF12
db: PANTHER Family
relationship type: By Homology

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P9WQ07 145
organism: Mycobacterium tuberculosis

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P9WHQ9 56
organism: Mycobacterium tuberculosis

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q38CA0 59
organism: Trypanosoma brucei

uniprot P27605 54
type: UnificationXref
id: P27605
db: uniprot

Deoxyadenosine phosphorylase
type: ProteinReference
xref: P02808
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Deoxyadenosine phosphorylase Synonym: Synonym not specified Accession: P02808
comment: ENTITY_REFERENCE_ID_DESC=Adenine and hypoxanthine salvage pathway.PROTEIN.GENERIC.Deoxyadenosine_br_phosphorylase
member entity reference: Purine nucleoside phosphorylase 1
member entity reference: Purine nucleoside phosphorylase
member entity reference: Putative purine nucleoside phosphorylase
member entity reference: AGAP005945-PA
member entity reference: Uncharacterized protein, isoform H

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P27605 54
organism: Rattus norvegicus

AGAP005945-PA
type: ProteinReference
xref: uniprot A4Q998 6
organism: Anopheles gambiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__deoxyribose_1_phosphate-_hypoxanthine-RIGHT__deoxyinosine-_PO4-_r5
controller: Deoxyinosine phosphorylase

uniprot Q8X1T6 97
type: UnificationXref
id: Q8X1T6
db: uniprot

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot A0A452DJA8 2
xref: PTHR11904:SF12
organism: Bos taurus

uniprot P47989 116
type: UnificationXref
id: P47989
db: uniprot

uniprot P9WQ07 145
type: UnificationXref
id: P9WQ07
db: uniprot

uniprot P46354 20
type: UnificationXref
id: P46354
db: uniprot

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8RDM9 150
organism: Fusobacterium nucleatum

uniprot Q89ZJ1 66
type: UnificationXref
id: Q89ZJ1
db: uniprot

uniprot Q9EWV2 27
type: UnificationXref
id: Q9EWV2
db: uniprot

uniprot Q9X1T2 31
type: UnificationXref
id: Q9X1T2
db: uniprot

STATE_TRANSITION_LEFT__PRPP-_adenine-RIGHT__AMP-_PPi-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 190
left: adenine
left: PRPP
interaction type: STATE_TRANSITION
right: AMP
right: PPi

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 67

ncbitaxon 7227 15
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot Q9X7T2 107
type: UnificationXref
id: Q9X7T2
db: uniprot

uniprot F4JLI5 109
type: UnificationXref
id: F4JLI5
db: uniprot

Adenosine deaminase
type: Protein
entity reference: Adenosine deaminase
comment: SPECIES_TYPE=PROTEIN

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 30

PARTICIPANT STOICHIOMETRY r7 194
type: Stoichiometry
physical entity: deoxyadenosine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 195
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 196
type: Stoichiometry
physical entity: deoxyribose-1-phosphate
stoichiometric coefficient: 1.0

uniprot Q9EWG8 123
type: UnificationXref
id: Q9EWG8
db: uniprot

uniprot H2KYI5 85
type: UnificationXref
id: H2KYI5
db: uniprot

uniprot Q4QCC3 63
type: UnificationXref
id: Q4QCC3
db: uniprot

Hypoxanthine phosphoribosyl transferase
type: Protein
entity reference: Hypoxanthine phosphoribosyl transferase
comment: SPECIES_TYPE=PROTEIN

Adenine deaminase
type: ProteinReference
xref: uniprot Q9P6I7 103
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r7 197
type: Stoichiometry
physical entity: adenine
stoichiometric coefficient: 1.0

uniprot A0A2I3SA16 83
type: UnificationXref
id: A0A2I3SA16
db: uniprot

ACEtyl-CoA Regulator
type: ProteinReference
xref: uniprot Q18599 94
organism: Caenorhabditis elegans

Adenine deaminase
type: ProteinReference
xref: uniprot Q9I6Y4 101
organism: Pseudomonas aeruginosa

ncbitaxon 9615 65
type: UnificationXref
id: 9615
db: ncbitaxon

Uncharacterized deaminase C1683.02
type: ProteinReference
xref: uniprot Q9P6J8 104
organism: Schizosaccharomyces pombe

Adenine phosphoribosyl transferase
type: Protein
entity reference: Adenine phosphoribosyl transferase
comment: SPECIES_TYPE=PROTEIN

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 77

Adenine phosphoribosyltransferase 4
type: ProteinReference
xref: uniprot Q9SU38 154
organism: Arabidopsis thaliana

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 17

uniprot B2RYS6 42
type: UnificationXref
id: B2RYS6
db: uniprot

Aminodeoxyfutalosine deaminase
type: ProteinReference
xref: uniprot O86737 86
organism: Streptomyces coelicolor

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot P00491 16
organism: Homo sapiens

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P00492 52
organism: Homo sapiens

PTHR11908:SF80
type: RelationshipXref
id: PTHR11908:SF80
db: PANTHER Family
relationship type: By Homology

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P00493 53
organism: Mus musculus

ncbitaxon 7955 39
type: UnificationXref
id: 7955
db: ncbitaxon

Adenine phosphoribosyltransferase 3
type: ProteinReference
xref: uniprot Q9SUW2 155
organism: Arabidopsis thaliana

Deoxyinosine phosphorylase
type: ProteinReference
xref: P02812
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Deoxyinosine phosphorylase Synonym: Synonym not specified Accession: P02812
comment: ENTITY_REFERENCE_ID_DESC=Adenine and hypoxanthine salvage pathway.PROTEIN.GENERIC.Deoxyinosine_br_phosphorylase
member entity reference: Purine nucleoside phosphorylase 1
member entity reference: Purine nucleoside phosphorylase
member entity reference: Putative purine nucleoside phosphorylase
member entity reference: AGAP005945-PA
member entity reference: Uncharacterized protein, isoform H

ncbitaxon 83332 23
type: UnificationXref
id: 83332
db: ncbitaxon

uniprot Q9UTG1 29
type: UnificationXref
id: Q9UTG1
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 45

Adenine phosphoribosyl transferase
type: ProteinReference
xref: P02810
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Adenine phosphoribosyl transferase Synonym: Synonym not specified Accession: P02810
comment: ENTITY_REFERENCE_ID_DESC=Adenine and hypoxanthine salvage pathway.PROTEIN.GENERIC.Adenine phosphoribosyl_br_transferase
member entity reference: APRT isoform 1
member entity reference: Adenine phosphoribosyltransferase 5
member entity reference: Adenine phosphoribosyltransferase
member entity reference: Xanthine phosphoribosyltransferase
member entity reference: Adenine phosphoribosyltransferase 1
member entity reference: Protein CBG14916
member entity reference: Uncharacterized protein
member entity reference: Adenine phosphoribosyltransferase 3
member entity reference: Adenine phosphoribosyltransferase 2
member entity reference: AGAP005723-PA
member entity reference: Adenine phosphoribosyltransferase 4

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: PTHR11908:SF80
xref: uniprot P80457 118
organism: Bos taurus

Xanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9RTY2 153
organism: Deinococcus radiodurans

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A0A452DIE3 126
organism: Bos taurus

uniprot F6T5C3 130
type: UnificationXref
id: F6T5C3
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 23

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P91455 144
organism: Caenorhabditis elegans

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r14 176
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

hypoxanthine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r14 175
type: Stoichiometry
physical entity: IMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 174
type: Stoichiometry
physical entity: PRPP
stoichiometric coefficient: 1.0

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot P9WP01 22
organism: Mycobacterium tuberculosis

uniprot Q7Q9M2 95
type: UnificationXref
id: Q7Q9M2
db: uniprot

PARTICIPANT STOICHIOMETRY r14 173
type: Stoichiometry
physical entity: hypoxanthine
stoichiometric coefficient: 1.0

PRPP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 90

Danio rerio
type: BioSource
xref: ncbitaxon 7955 39

Adenine deaminase
type: ProteinReference
xref: uniprot Q9RDE5 105
organism: Streptomyces coelicolor

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9X1A4 156
organism: Thermotoga maritima

adenosine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QEF0 82
organism: Macaca mulatta

STATE_TRANSITION_LEFT__PO4-_inosine-RIGHT__hypoxanthine-_ribose_1_phosphate-_r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 188
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 186
left: inosine
left: PO4
interaction type: STATE_TRANSITION
right: ribose-1-phosphate
right: hypoxanthine

Deoxyadenosine deaminase
type: Protein
entity reference: Deoxyadenosine deaminase
comment: SPECIES_TYPE=PROTEIN

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P36972 137
organism: Rattus norvegicus

uniprot P22985 115
type: UnificationXref
id: P22985
db: uniprot

Adenine phosphoribosyltransferase 2
type: ProteinReference
xref: uniprot P36973 138
organism: Saccharomyces cerevisiae

Probable purine/pyrimidine phosphoribosyl transferase
type: ProteinReference
xref: uniprot Q9HVE7 72
organism: Pseudomonas aeruginosa

ncbitaxon 5664 62
type: UnificationXref
id: 5664
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot H2KYI5 85
organism: Caenorhabditis elegans

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9NF11 74
organism: Caenorhabditis elegans

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot P37472 55
organism: Bacillus subtilis

ncbitaxon 3702 45
type: UnificationXref
id: 3702
db: ncbitaxon

Probable aldehyde oxidase gad-3
type: ProteinReference
xref: uniprot Q960A1 122
organism: Caenorhabditis elegans

uniprot F6T0Z6 10
type: UnificationXref
id: F6T0Z6
db: uniprot

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 71

Uncharacterized protein
type: ProteinReference
xref: uniprot O61198 113
organism: Caenorhabditis elegans

Xanthine dehydrogenase
type: ProteinReference
xref: PTHR11908:SF100
xref: uniprot P10351 114
organism: Drosophila melanogaster

uniprot P23492 18
type: UnificationXref
id: P23492
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PO4-_inosine-RIGHT__hypoxanthine-_ribose_1_phosphate-_r11
controller: Inosine phosphorylase

uniprot Q9WY49 80
type: UnificationXref
id: Q9WY49
db: uniprot

uniprot A8XKZ6 127
type: UnificationXref
id: A8XKZ6
db: uniprot

uniprot P07741 134
type: UnificationXref
id: P07741
db: uniprot

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot O34443 132
organism: Bacillus subtilis

uniprot Q8RGK5 70
type: UnificationXref
id: Q8RGK5
db: uniprot

uniprot Q9NRG1 75
type: UnificationXref
id: Q9NRG1
db: uniprot

ncbitaxon 9913 3
type: UnificationXref
id: 9913
db: ncbitaxon

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 58

uniprot A8X1Q6 84
type: UnificationXref
id: A8X1Q6
db: uniprot

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot H2Q7W4 12
organism: Pan troglodytes

ncbitaxon 100226 28
type: UnificationXref
id: 100226
db: ncbitaxon

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: De novo purine biosynthesis
controller: IMP

uniprot Q4Q9H8 148
type: UnificationXref
id: Q4Q9H8
db: uniprot

uniprot A0A2R8QRE7 38
type: UnificationXref
id: A0A2R8QRE7
db: uniprot

Adenosine deaminase-like protein
type: ProteinReference
xref: uniprot Q9VHH7 106
organism: Drosophila melanogaster

uniprot Q960A1 122
type: UnificationXref
id: Q960A1
db: uniprot

uniprot Q920P6 99
type: UnificationXref
id: Q920P6
db: uniprot

uniprot P03958 88
type: UnificationXref
id: P03958
db: uniprot

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

uniprot P52561 141
type: UnificationXref
id: P52561
db: uniprot

IMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__H2O-_adenosine-RIGHT__NH3-_inosine-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 168
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 166
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 167
left: adenosine
left: H2O
interaction type: STATE_TRANSITION
right: inosine
right: NH3

uniprot O34443 132
type: UnificationXref
id: O34443
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 43

Adenine deaminase
type: ProteinReference
xref: uniprot Q8X1T6 97
organism: Emericella nidulans

ribose-1-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Adenosine deaminase-like protein
type: ProteinReference
xref: uniprot Q80SY6 96
organism: Mus musculus

Xanthine dehydrogenase 1
type: ProteinReference
xref: uniprot Q8GUQ8 121
organism: Arabidopsis thaliana

uniprot P49435 140
type: UnificationXref
id: P49435
db: uniprot

De novo purine biosynthesis
type: Pathway

Adenosine deaminase
type: ProteinReference
xref: uniprot Q920P6 99
organism: Rattus norvegicus

uniprot O66821 50
type: UnificationXref
id: O66821
db: uniprot

uniprot P00813 87
type: UnificationXref
id: P00813
db: uniprot

Xanthine dehydrogenase/oxidase
type: ProteinReference
xref: uniprot Q00519 119
xref: PTHR11908:SF80
organism: Mus musculus

uniprot Q9D8C9 26
type: UnificationXref
id: Q9D8C9
db: uniprot

STATE_TRANSITION_LEFT__inosine-_ATP-RIGHT__IMP-_ADP-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 161
left: inosine
left: ATP
interaction type: STATE_TRANSITION
right: IMP
right: ADP

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q9EWV2 27
organism: Streptomyces coelicolor

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__deoxyadenosine-_PO4-RIGHT__deoxyribose_1_phosphate-_adenine-_r7
controller: Deoxyadenosine phosphorylase

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__deoxyadenosine-_PO4-RIGHT__deoxyribose_1_phosphate-_adenine-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 196
left: deoxyadenosine
left: PO4
interaction type: STATE_TRANSITION
right: adenine
right: deoxyribose-1-phosphate

Adenosine deaminase
type: ProteinReference
xref: uniprot P56658 92
organism: Bos taurus

uniprot P36972 137
type: UnificationXref
id: P36972
db: uniprot

uniprot Q9HTQ6 151
type: UnificationXref
id: Q9HTQ6
db: uniprot

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A0A2I3TEX9 37
organism: Pan troglodytes

Adenine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q04633 146
organism: Pseudomonas aeruginosa

uniprot P00493 53
type: UnificationXref
id: P00493
db: uniprot

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot Q05788 24
organism: Saccharomyces cerevisiae

uniprot Q9P6I7 103
type: UnificationXref
id: Q9P6I7
db: uniprot

uniprot F7AT83 47
type: UnificationXref
id: F7AT83
db: uniprot

Adenosine deaminase 2
type: ProteinReference
xref: uniprot Q9X7T2 107
organism: Streptomyces coelicolor

STATE_TRANSITION
type: InteractionVocabulary

Inosine phosphorylase
type: ProteinReference
xref: P02813
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Adenine and hypoxanthine salvage pathway.PROTEIN.GENERIC.Inosine_br_phosphorylase
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Purine nucleoside phosphorylase 1
member entity reference: Purine nucleoside phosphorylase
member entity reference: Putative purine nucleoside phosphorylase
member entity reference: AGAP005945-PA
member entity reference: Uncharacterized protein, isoform H

ncbitaxon 10116 43
type: UnificationXref
id: 10116
db: ncbitaxon

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot A8XI15 8
organism: Caenorhabditis briggsae

Xanthine dehydrogenase
type: Protein
entity reference: Xanthine dehydrogenase
comment: SPECIES_TYPE=PROTEIN

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q6WIT9 64
organism: Canis lupus familiaris

uniprot Q42563 147
type: UnificationXref
id: Q42563
db: uniprot

NH3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P53909 91
type: UnificationXref
id: P53909
db: uniprot

PARTICIPANT STOICHIOMETRY r11 188
type: Stoichiometry
physical entity: hypoxanthine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 187
type: Stoichiometry
physical entity: inosine
stoichiometric coefficient: 1.0

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r11 189
type: Stoichiometry
physical entity: ribose-1-phosphate
stoichiometric coefficient: 1.0

AGAP005723-PA
type: ProteinReference
xref: uniprot Q7Q6Q8 149
organism: Anopheles gambiae

ncbitaxon 6239 35
type: UnificationXref
id: 6239
db: ncbitaxon

ncbitaxon 9031 79
type: UnificationXref
id: 9031
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r11 186
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

ncbitaxon 243274 32
type: UnificationXref
id: 243274
db: ncbitaxon

Uncharacterized protein, isoform H
type: ProteinReference
xref: uniprot M9PE19 14
organism: Drosophila melanogaster

2 H+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 83333 90
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot Q9AK25 100
type: UnificationXref
id: Q9AK25
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 62

Hypoxanthine phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8IJS1 68
organism: Plasmodium falciparum

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot U4PSA1 34
organism: Caenorhabditis elegans

Deoxyadenosine deaminase
type: ProteinReference
xref: P02807
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Adenine and hypoxanthine salvage pathway.PROTEIN.GENERIC.Deoxyadenosine_br_deaminase
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Adenosine deaminase
member entity reference: Adenine deaminase
member entity reference: ACEtyl-CoA Regulator
member entity reference: Adenosine deaminase 1
member entity reference: Uncharacterized protein
member entity reference: Aminodeoxyfutalosine deaminase
member entity reference: Adenosine deaminase-like protein
member entity reference: AGAP005158-PA
member entity reference: Protein CBG05749
member entity reference: Adenosine deaminase 2
member entity reference: Putative adenosine/adenine deaminase
member entity reference: Uncharacterized deaminase C1683.02

uniprot Q8IJS1 68
type: UnificationXref
id: Q8IJS1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_hypoxanthine-RIGHT__2_H_PLUS_-_xanthine-_r12
controller: Xanthine dehydrogenase

Hypoxanthine-guanine phosphoribosyltransferase
type: ProteinReference
xref: uniprot A5A6I1 40
organism: Pan troglodytes

uniprot Q9RDE5 105
type: UnificationXref
id: Q9RDE5
db: uniprot

inosine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9HVE7 72
type: UnificationXref
id: Q9HVE7
db: uniprot

ncbitaxon 7165 7
type: UnificationXref
id: 7165
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r1 169
type: Stoichiometry
physical entity: ribose-1-phosphate
stoichiometric coefficient: 1.0

uniprot P91455 144
type: UnificationXref
id: P91455
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 98

Purine nucleoside phosphorylase
type: ProteinReference
xref: uniprot F6T0Z6 10
organism: Macaca mulatta

uniprot Q12553 120
type: UnificationXref
id: Q12553
db: uniprot

STATE_TRANSITION_LEFT__hypoxanthine-_PRPP-RIGHT__IMP-_PPi-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 175
left: hypoxanthine
left: PRPP
interaction type: STATE_TRANSITION
right: IMP
right: PPi

AGAP005158-PA
type: ProteinReference
xref: uniprot Q7Q9M2 95
organism: Anopheles gambiae