ncbitaxon 8364 12
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot Q64093 108
type: UnificationXref
id: Q64093
db: uniprot

SNARE
type: ProteinReference
xref: P00072
standard name: N-ethylmaleimide-sensitive factor attachment protein receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P00072
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.SNARE
member entity reference: Synaptosomal-associated protein 29
member entity reference: Uncharacterized protein
member entity reference: Synaptosomal-associated protein 25
member entity reference: Synaptobrevin-A
member entity reference: Synaptosomal-associated protein
member entity reference: VAMP2 isoform 3
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Vesicle transport through interaction with t-SNAREs homolog 1B
member entity reference: Syntaxin-7
member entity reference: Putative syntaxin-24
member entity reference: Syntaxin 12
member entity reference: Vesicle-associated membrane protein 2
member entity reference: LD03592p
member entity reference: Syntaxin 7
member entity reference: Syntaxin-12
member entity reference: LD23667p
member entity reference: STX12 isoform 1
member entity reference: Synaptosomal-associated protein 25-B
member entity reference: Synaptosomal-associated protein 25-A
member entity reference: Protein CBR-SYX-7
member entity reference: Longin-type vesicle-associated membrane protein putative
member entity reference: Vesicle associated membrane protein 1
member entity reference: STX7 isoform 4
member entity reference: STX12 protein
member entity reference: Os01g0254900 protein
member entity reference: Synaptobrevin homolog 1
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: Synaptobrevin
member entity reference: Syntaxin-21
member entity reference: AGAP005543-PA
member entity reference: Syntaxin-23
member entity reference: SYntaXin
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Syntaxin 7-like
member entity reference: Syntaxin PEP12
member entity reference: Synaptosomal-associated protein 23
member entity reference: Synaptobrevin homolog 2
member entity reference: t-SNARE protein aex-4
member entity reference: SNAP25 homologous protein SNAP33
member entity reference: SNAP29 isoform 1
member entity reference: Soluble NSF attachment protein 29

VAT1
type: Protein
entity reference: VAT1
cellular location: dense core granule
comment: SPECIES_TYPE=PROTEIN

Syntaxin-22
type: ProteinReference
xref: uniprot P93654 210
organism: Arabidopsis thaliana

PTHR11616:SF245
type: RelationshipXref
id: PTHR11616:SF245
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot A0A1D5QYR9 156
organism: Macaca mulatta

uniprot Q9S7P9 239
type: UnificationXref
id: Q9S7P9
db: uniprot

uniprot Q61327 65
type: UnificationXref
id: Q61327
db: uniprot

uniprot A5D6R9 88
type: UnificationXref
id: A5D6R9
db: uniprot

STATE_TRANSITION_LEFT__dopamine-RIGHT__norepinephrine-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 320
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 321
left: dopamine
interaction type: STATE_TRANSITION
right: norepinephrine

Sodium-dependent neutral amino acid transporter B(0)AT3
type: ProteinReference
xref: PTHR11616:SF109
xref: uniprot Q62687 107
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__epinephrine-_Mg2_PLUS_-RIGHT__Mg2_PLUS_-_a16_degraded-_r17
controller: MAO

uniprot H2Q995 178
type: UnificationXref
id: H2Q995
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot L7N2T4 20
organism: Xenopus tropicalis

Sodium-dependent neutral amino acid transporter B(0)AT1
type: ProteinReference
xref: PTHR11616:SF125
xref: uniprot Q9D687 116
organism: Mus musculus

ncbitaxon 9606 24
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot J9NYA0 182
type: UnificationXref
id: J9NYA0
db: uniprot

uniprot Q9Z2P6 244
type: UnificationXref
id: Q9Z2P6
db: uniprot

?
type: Pathway

Sodium-dependent dopamine transporter
type: ProteinReference
xref: PTHR11616:SF38
xref: uniprot Q01959 64
organism: Homo sapiens

uniprot P63025 206
type: UnificationXref
id: P63025
db: uniprot

uniprot Q28HP6 213
type: UnificationXref
id: Q28HP6
db: uniprot

Catechol O-methyltransferase
type: ProteinReference
xref: PTHR43836:SF3
xref: uniprot P22734 141
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__DOPA-RIGHT__dopamine-_r29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 338
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 337
left: DOPA
interaction type: STATE_TRANSITION
right: dopamine

Sodium-dependent neutral amino acid transporter B(0)AT2
type: ProteinReference
xref: PTHR11616:SF101
xref: uniprot Q08469 105
organism: Rattus norvegicus

uniprot P58200 200
type: UnificationXref
id: P58200
db: uniprot

Tyrosine 3-monooxygenase
type: ProteinReference
xref: uniprot P04177 37
xref: PTHR11473:SF18
organism: Rattus norvegicus

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: uniprot Q64133 134
xref: PTHR43563:SF11
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 22

Zgc:64002
type: ProteinReference
xref: uniprot F1QUL7 9
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XYX9 167
xref: PTHR45701:SF6
organism: Monodelphis domestica

uniprot Q8R090 153
type: UnificationXref
id: Q8R090
db: uniprot

uniprot Q9GNP0 154
type: UnificationXref
id: Q9GNP0
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 196

Dopamine beta-hydroxylase
type: ProteinReference
xref: uniprot Q64237 50
xref: PTHR10157:SF29
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mg2_PLUS_-_norepinephrine-RIGHT__Mg2_PLUS_-_a15_degraded-_r18
controller: MAO

epinephrine
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

norepinephrine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa2 262
cellular location: dense core granule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 41

PARTICIPANT STOICHIOMETRY r38 280
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

GO GO:0031045 2
type: UnificationXref
id: GO:0031045
db: GO

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

NET
type: Protein
entity reference: NET
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A1Z6N4 67
type: UnificationXref
id: A1Z6N4
db: uniprot

Solute carrier family 6 member 18
type: ProteinReference
xref: PTHR11616:SF109
xref: uniprot H2R3L2 101
organism: Pan troglodytes

Synaptic vesicular amine transporter
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot Q01827 145
organism: Rattus norvegicus

uniprot Q7SZR0 81
type: UnificationXref
id: Q7SZR0
db: uniprot

Syntaxin-7
type: ProteinReference
xref: uniprot O70439 190
xref: PTHR19957:SF90
organism: Mus musculus

uniprot P09172 47
type: UnificationXref
id: P09172
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__DOPA-RIGHT__DOPA-_r30
control type: ACTIVATION
controller: SNARE

uniprot Q8BG16 112
type: UnificationXref
id: Q8BG16
db: uniprot

uniprot P34751 76
type: UnificationXref
id: P34751
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mg2_PLUS_-_dopamine-RIGHT__Mg2_PLUS_-_a30_degraded-_r26
controller: COMT

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot F6UFJ7 165
xref: PTHR19305:SF9
organism: Macaca mulatta

Transporter
type: ProteinReference
xref: PTHR11616:SF101
xref: uniprot H2Q6J9 99
organism: Pan troglodytes

uniprot Q20308 33
type: UnificationXref
id: Q20308
db: uniprot

Tyrosine 3-monooxygenase
type: ProteinReference
xref: PTHR11473:SF15
xref: uniprot P90986 43
organism: Caenorhabditis elegans

Transporter
type: ProteinReference
xref: uniprot A5D6R9 88
xref: PTHR11616:SF285
organism: Danio rerio

Syntaxin-12
type: ProteinReference
xref: uniprot Q9ER00 234
xref: PTHR19957:SF88
organism: Mus musculus

uniprot F7GJ89 97
type: UnificationXref
id: F7GJ89
db: uniprot

Amine oxidase
type: ProteinReference
xref: PTHR43563:SF5
xref: uniprot H2QYH6 127
organism: Pan troglodytes

uniprot F7E0Z1 172
type: UnificationXref
id: F7E0Z1
db: uniprot

Amine oxidase
type: ProteinReference
xref: uniprot H2QYH5 126
xref: PTHR43563:SF11
organism: Pan troglodytes

Syntaxin-23
type: ProteinReference
xref: uniprot O04378 184
organism: Arabidopsis thaliana

Vesicle transport through interaction with t-SNAREs homolog 1B
type: ProteinReference
xref: PTHR21230:SF79
xref: uniprot F7C233 169
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mg2_PLUS_-_norepinephrine-RIGHT__Mg2_PLUS_-_a15_degraded-_r18
controller: COMT

COMT
type: Protein
entity reference: COMT
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r38 279
type: Stoichiometry
physical entity: VAT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 278
type: Stoichiometry
physical entity: Complex (VAT1/epinephrine)
stoichiometric coefficient: 1.0

Dopa decarboxylase
type: ProteinReference
xref: uniprot A0A2I3TP36 66
xref: PTHR11999:SF70
organism: Pan troglodytes

uniprot P27338 132
type: UnificationXref
id: P27338
db: uniprot

uniprot F6UBJ8 164
type: UnificationXref
id: F6UBJ8
db: uniprot

uniprot H2Q2M8 144
type: UnificationXref
id: H2Q2M8
db: uniprot

DAT
type: Protein
entity reference: DAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa11 264
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2RCB8 181
type: UnificationXref
id: H2RCB8
db: uniprot

Transporter
type: ProteinReference
xref: PTHR11616:SF101
xref: uniprot F7F542 95
organism: Monodelphis domestica

COMT isoform 1
type: ProteinReference
xref: PTHR43836:SF3
xref: uniprot H2QL91 138
organism: Pan troglodytes

Adrenaline and noradrenaline biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__norepinephrine-RIGHT__epinephrine-_r31
pathway component: HETERODIMER_ASSOCIATION_LEFT__VAT1-_epinephrine-RIGHT__Complex__VAT1_epinephrine_-_r37
pathway component: TRANSPORT_LEFT__dopamine-RIGHT__dopamine-_r22
pathway component: DISSOCIATION_LEFT__Complex__NET_norepinephrine_-RIGHT__norepinephrine-_NET-_Na_PLUS_-_r41
pathway component: HETERODIMER_ASSOCIATION_LEFT__DOPA-_VAT2-RIGHT__Complex__VAT2_DOPA_-_r45
pathway component: TRANSPORT_LEFT__epinephrine-RIGHT__epinephrine-_r34
pathway component: STATE_TRANSITION_LEFT__epinephrine-_Mg2_PLUS_-RIGHT__Mg2_PLUS_-_a16_degraded-_r17
pathway component: DISSOCIATION_LEFT__Complex__VAT1_norepinephrine_-RIGHT__norepinephrine-_VAT1-_r39
pathway component: HETERODIMER_ASSOCIATION_LEFT__VAT1-_norepinephrine-RIGHT__Complex__VAT1_norepinephrine_-_r36
pathway component: TRANSPORT_LEFT__DOPA-RIGHT__DOPA-_r30
pathway component: STATE_TRANSITION_LEFT__Mg2_PLUS_-_norepinephrine-RIGHT__Mg2_PLUS_-_a15_degraded-_r18
pathway component: TRANSPORT_LEFT__epinephrine-RIGHT__epinephrine-_r16
pathway component: DISSOCIATION_LEFT__Complex__VAT2_DOPA_-RIGHT__DOPA-_VAT2-_r46
pathway component: HETERODIMER_ASSOCIATION_LEFT__Na_PLUS_-_dopamine-_DAT-RIGHT__Complex__DAT_dopamine_-_r47
pathway component: STATE_TRANSITION_LEFT__DOPA-RIGHT__dopamine-_r29
pathway component: DISSOCIATION_LEFT__Complex__DAT_dopamine_-RIGHT__dopamine-_Na_PLUS_-_DAT-_r48
pathway component: DISSOCIATION_LEFT__Complex__VAT1_epinephrine_-RIGHT__VAT1-_epinephrine-_r38
pathway component: STATE_TRANSITION_LEFT__Mg2_PLUS_-_dopamine-RIGHT__Mg2_PLUS_-_a30_degraded-_r26
pathway component: HETERODIMER_ASSOCIATION_LEFT__epinephrine-_amine_translocator-RIGHT__Complex__amine_translocator_epinephrine_-_r42
pathway component: STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_r3
pathway component: HETERODIMER_ASSOCIATION_LEFT__Na_PLUS_-_NET-_norepinephrine-RIGHT__Complex__NET_norepinephrine_-_r40
pathway component: TRANSPORT_LEFT__norepinephrine-RIGHT__norepinephrine-_r11
pathway component: STATE_TRANSITION_LEFT__dopamine-RIGHT__norepinephrine-_r5
pathway component: DISSOCIATION_LEFT__Complex__amine_translocator_epinephrine_-RIGHT__epinephrine-_amine_translocator-_r43
xref: PANTHER Pathway P00001 1
comment: MODEL_NOTES=Synthesis of catecholamines from dietary tyrosine to dopamine, norepinephrine and epinephrine is crucial for brain development. Dopamine primarily functions in the central nervous system as a modifier of fine movement (eg. Parkinsons disease occurs when dopamine is lacking primarily in late life), or in brain reward pathways (eg. schizophrenia occurs when dopamine is too abundant, primarily early in life). Epinephrine (adrenalin) and norepinephrine (noradrenalin) are the primary peripheral and central, respectively, vasoconstrictors. These hormones are involved in the fight or flight response in all vertebrates, and excessive levels of epinephrine have been found in animals in pack leader positions (alpha males). Website=http://www.beatcfsandfms.org/html/neurotransmitters.html Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1105716 Website=http://www.neuro.wustl.edu/neuromuscular/lab/catechol.htm#comt Website=http://www.nobel.se/medicine/laureates/1970/axelrod-lecture.pdf Website=http://www.pharmacology2000.com/lectures/Autonomics/Introduction/page4.htm

uniprot Q7SZZ5 227
type: UnificationXref
id: Q7SZZ5
db: uniprot

uniprot Q6PC54 222
type: UnificationXref
id: Q6PC54
db: uniprot

ncbitaxon 10116 7
type: UnificationXref
id: 10116
db: ncbitaxon

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60879 203
xref: PTHR19305:SF5
organism: Mus musculus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60878 202
xref: PTHR19305:SF5
organism: Gallus gallus

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9Z2P6 244
organism: Rattus norvegicus

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: PTHR11616:SF245
xref: uniprot P23975 59
organism: Homo sapiens

Transporter
type: ProteinReference
xref: uniprot F7B2G1 94
xref: PTHR11616:SF44
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Mg2_PLUS_-_norepinephrine-RIGHT__Mg2_PLUS_-_a15_degraded-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 295
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 293
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 294
left: Mg2+
left: norepinephrine
interaction type: STATE_TRANSITION
right: Mg2+
right: a15_degraded

PTHR11616:SF285
type: RelationshipXref
id: PTHR11616:SF285
db: PANTHER Family
relationship type: By Homology

uniprot Q9NP91 120
type: UnificationXref
id: Q9NP91
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__dopamine-RIGHT__dopamine-_r22
control type: ACTIVATION
controller: SNARE

uniprot Q9S7H0 238
type: UnificationXref
id: Q9S7H0
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q5R1X1 218
xref: PTHR19305:SF5
organism: Pan troglodytes

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60877 201
organism: Macaca mulatta

uniprot Q7PW49 79
type: UnificationXref
id: Q7PW49
db: uniprot

VAT2
type: ProteinReference
xref: P00070
standard name: Synaptic vesicular amine transporter
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Synaptic vesicular amine transporter Synonym: Monoamine transporter,Solute carrier family 18 member 2,VAT2,Vesicular amine transporter 2 Accession: P00070
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.VAT2
member entity reference: SLC18A2 isoform 1
member entity reference: Synaptic vesicular amine transporter
member entity reference: Solute carrier family 18 (Vesicular monoamine), member 2
member entity reference: Uncharacterized protein

DOPA
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR11616:SF282
type: RelationshipXref
id: PTHR11616:SF282
db: PANTHER Family
relationship type: By Homology

uniprot Q62687 107
type: UnificationXref
id: Q62687
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60880 204
xref: PTHR19305:SF5
organism: Homo sapiens

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 5

uniprot G5EEN8 175
type: UnificationXref
id: G5EEN8
db: uniprot

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot O88533 72
xref: PTHR11999:SF70
organism: Mus musculus

eco ECO:0000250 17
type: UnificationXref
id: ECO:0000250
db: eco

HETERODIMER_ASSOCIATION_LEFT__VAT1-_norepinephrine-RIGHT__Complex__VAT1_norepinephrine_-_r36
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 284
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 285
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 286
left: norepinephrine
left: VAT1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (VAT1/norepinephrine)

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 12

Complex (NET/norepinephrine)
type: Complex
component stoichiometry: Na PLUS s63 sa55 STOICHIOMETRY ID COMPLEX
component stoichiometry: NET s23 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: norepinephrine s26 sa6 STOICHIOMETRY ID COMPLEX
component: Na+
component: NET
component: norepinephrine
feature: COMPLEX BINDING FEATURE s52 a59 255
feature: COMPLEX BINDING FEATURE s52 a59 253
feature: COMPLEX BINDING FEATURE s52 a59 257
cellular location: cytosol

uniprot Q9MYW8 61
type: UnificationXref
id: Q9MYW8
db: uniprot

norepinephrine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q05754 49
type: UnificationXref
id: Q05754
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot Q2KJD2 215
xref: PTHR45701:SF6
organism: Bos taurus

Nicotinamide N-methyltransferase
type: ProteinReference
xref: uniprot P34254 28
organism: Caenorhabditis elegans

uniprot F7FNW0 70
type: UnificationXref
id: F7FNW0
db: uniprot

Amine oxidase
type: ProteinReference
xref: uniprot F7D3H3 125
xref: PTHR43563:SF5
organism: Macaca mulatta

Chromaffin granule amine transporter
type: ProteinReference
xref: uniprot Q01818 151
xref: PTHR23506:SF31
organism: Rattus norvegicus

TRIGGER
type: RelationshipTypeVocabulary

uniprot G3V7P1 174
type: UnificationXref
id: G3V7P1
db: uniprot

uniprot Q08469 105
type: UnificationXref
id: Q08469
db: uniprot

uniprot Q2KIU0 214
type: UnificationXref
id: Q2KIU0
db: uniprot

PTHR10157:SF29
type: RelationshipXref
id: PTHR10157:SF29
db: PANTHER Family
relationship type: By Homology

Tyrosine 3-monooxygenase
type: ProteinReference
xref: uniprot P24529 42
xref: PTHR11473:SF18
organism: Mus musculus

uniprot Q3ZBT5 217
type: UnificationXref
id: Q3ZBT5
db: uniprot

Sodium-dependent neutral amino acid transporter B(0)AT2
type: ProteinReference
xref: PTHR11616:SF101
xref: uniprot Q9XS59 121
organism: Bos taurus

PNMT isoform 1
type: ProteinReference
xref: PTHR10867:SF18
xref: uniprot H2QCU9 16
organism: Pan troglodytes

uniprot A5PEW5 157
type: UnificationXref
id: A5PEW5
db: uniprot

uniprot P21398 131
type: UnificationXref
id: P21398
db: uniprot

PARTICIPANT STOICHIOMETRY r16 310
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

Na+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

uniprot F1QUL7 9
type: UnificationXref
id: F1QUL7
db: uniprot

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot P20711 75
xref: PTHR11999:SF70
organism: Homo sapiens

Transporter
type: ProteinReference
xref: uniprot J9NVM9 102
xref: PTHR11616:SF102
organism: Canis lupus familiaris

uniprot F6V922 124
type: UnificationXref
id: F6V922
db: uniprot

uniprot L7N2T4 20
type: UnificationXref
id: L7N2T4
db: uniprot

PARTICIPANT STOICHIOMETRY r16 309
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

uniprot A7MAZ2 159
type: UnificationXref
id: A7MAZ2
db: uniprot

Uncharacterized LOC100145174
type: ProteinReference
xref: uniprot F7BI54 13
organism: Xenopus tropicalis

Phenylethanolamine N-methyltransferase
type: ProteinReference
xref: PTHR10867:SF18
xref: uniprot P10938 25
organism: Bos taurus

Sodium-dependent neutral amino acid transporter SLC6A17
type: ProteinReference
xref: uniprot Q8BJI1 113
xref: PTHR11616:SF102
organism: Mus musculus

VAT2 s33 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VAT2
stoichiometric coefficient: 1.0

uniprot A8X8S6 160
type: UnificationXref
id: A8X8S6
db: uniprot

ncbitaxon 5759 229
type: UnificationXref
id: 5759
db: ncbitaxon

Indolethylamine N-methyltransferase
type: ProteinReference
xref: uniprot F6YFA4 11
organism: Xenopus tropicalis

DAT
type: Protein
entity reference: DAT
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0B4K7V4 84
type: UnificationXref
id: A0A0B4K7V4
db: uniprot

Probable aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot P34751 76
organism: Caenorhabditis elegans

Os10g0380800 protein
type: ProteinReference
xref: uniprot Q7G6M2 77
organism: Oryza sativa

uniprot H2QGU3 100
type: UnificationXref
id: H2QGU3
db: uniprot

uniprot P15101 48
type: UnificationXref
id: P15101
db: uniprot

uniprot F7BI54 13
type: UnificationXref
id: F7BI54
db: uniprot

PARTICIPANT STOICHIOMETRY r18 294
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63027 208
xref: PTHR45701:SF5
organism: Homo sapiens

MIP05841p
type: ProteinReference
xref: uniprot A1Z6N4 67
organism: Drosophila melanogaster

uniprot G7MIF5 98
type: UnificationXref
id: G7MIF5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dopamine-RIGHT__norepinephrine-_r5
controller: DBH

PARTICIPANT STOICHIOMETRY r18 293
type: Stoichiometry
physical entity: Mg2+
stoichiometric coefficient: 1.0

uniprot Q5TZ66 219
type: UnificationXref
id: Q5TZ66
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63026 207
xref: PTHR45701:SF5
organism: Bos taurus

By Homology
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r22 274
type: Stoichiometry
physical entity: dopamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 296
type: Stoichiometry
physical entity: a15_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 295
type: Stoichiometry
physical entity: Mg2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 273
type: Stoichiometry
physical entity: dopamine
stoichiometric coefficient: 1.0

uniprot P63027 208
type: UnificationXref
id: P63027
db: uniprot

norepinephrine
type: SmallMolecule
cellular location: dense core granule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

epinephrine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot J9NVM9 102
type: UnificationXref
id: J9NVM9
db: uniprot

uniprot Q96N87 115
type: UnificationXref
id: Q96N87
db: uniprot

uniprot P23977 63
type: UnificationXref
id: P23977
db: uniprot

uniprot Q9C615 233
type: UnificationXref
id: Q9C615
db: uniprot

TRANSPORT_LEFT__dopamine-RIGHT__dopamine-_r22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 274
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 273
left: dopamine
interaction type: TRANSPORT
right: dopamine

HETERODIMER_ASSOCIATION_LEFT__DOPA-_VAT2-RIGHT__Complex__VAT2_DOPA_-_r45
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 315
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 316
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 314
left: VAT2
left: DOPA
interaction type: HETERODIMER_ASSOCIATION
right: Complex (VAT2/DOPA)

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 205
organism: Mus musculus

Transporter
type: ProteinReference
xref: uniprot A1A4L2 87
xref: PTHR11616:SF44
organism: Bos taurus

Synaptic vesicular amine transporter
type: ProteinReference
xref: uniprot Q05940 146
xref: PTHR23506:SF30
organism: Homo sapiens

Longin-type vesicle-associated membrane protein putative
type: ProteinReference
xref: uniprot Q7Z0T4 228
xref: PTHR21136:SF168
organism: Entamoeba histolytica

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63025 206
organism: Rattus norvegicus

uniprot P60877 201
type: UnificationXref
id: P60877
db: uniprot

norepinephrine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa6 256
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 10090 22
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot Q9VH76 242
type: UnificationXref
id: Q9VH76
db: uniprot

uniprot F7E0A0 170
type: UnificationXref
id: F7E0A0
db: uniprot

uniprot A0A0A0MPL4 155
type: UnificationXref
id: A0A0A0MPL4
db: uniprot

Catechol O-methyltransferase
type: ProteinReference
xref: PTHR43836:SF3
xref: uniprot P21964 140
organism: Homo sapiens

SLC18A2 isoform 1
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot H2Q2M8 144
organism: Pan troglodytes

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot F7FNW0 70
xref: PTHR11999:SF70
organism: Macaca mulatta

Syntaxin-7
type: ProteinReference
xref: uniprot Q3ZBT5 217
xref: PTHR19957:SF90
organism: Bos taurus

Amine oxidase [flavin-containing] B
type: ProteinReference
xref: PTHR43563:SF5
xref: uniprot P27338 132
organism: Homo sapiens

Transporter
type: ProteinReference
xref: PTHR11616:SF182
xref: uniprot A0A0B4K7V4 84
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RJP1 35
xref: PTHR11473:SF18
organism: Macaca mulatta

ncbitaxon 284812 232
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q17QQ3 212
type: UnificationXref
id: Q17QQ3
db: uniprot

VAMP2 isoform 3
type: ProteinReference
xref: uniprot H2RCB8 181
xref: PTHR45701:SF5
organism: Pan troglodytes

ncbitaxon 9258 171
type: UnificationXref
id: 9258
db: ncbitaxon

LD23667p
type: ProteinReference
xref: PTHR19957:SF38
xref: uniprot Q7K0X9 225
organism: Drosophila melanogaster

uniprot B7Z122 89
type: UnificationXref
id: B7Z122
db: uniprot

uniprot Q7PNQ5 226
type: UnificationXref
id: Q7PNQ5
db: uniprot

Transporter
type: ProteinReference
xref: uniprot F6WZU5 92
xref: PTHR11616:SF102
organism: Monodelphis domestica

uniprot A1A4L2 87
type: UnificationXref
id: A1A4L2
db: uniprot

tyrosine
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Sodium-dependent neutral amino acid transporter B(0)AT3
type: ProteinReference
xref: PTHR11616:SF109
xref: uniprot O88576 104
organism: Mus musculus

Amine oxidase [flavin-containing]
type: ProteinReference
xref: PTHR43563:SF5
xref: uniprot Q6NSN2 135
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r31 290
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

uniprot H2QUD4 19
type: UnificationXref
id: H2QUD4
db: uniprot

Sodium- and chloride-dependent transporter XTRP3B
type: ProteinReference
xref: uniprot O88575 103
xref: PTHR11616:SF44
organism: Mus musculus

Nicotinamide N-methyltransferase
type: ProteinReference
xref: uniprot O55239 21
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r31 289
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

Syntaxin-7
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot O70257 189
organism: Rattus norvegicus

Synaptobrevin homolog 1
type: ProteinReference
xref: PTHR45701:SF9
xref: uniprot Q92356 231
organism: Schizosaccharomyces pombe

ncbitaxon 3702 83
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot O44419 186
type: UnificationXref
id: O44419
db: uniprot

Transporter
type: ProteinReference
xref: uniprot Q6PBA3 110
xref: PTHR11616:SF125
organism: Danio rerio

amine translocator s60 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: amine translocator
stoichiometric coefficient: 1.0

Sodium-dependent neutral amino acid transporter B(0)AT2
type: ProteinReference
xref: PTHR11616:SF101
xref: uniprot Q9H2J7 119
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__Na_PLUS_-_dopamine-_DAT-RIGHT__Complex__DAT_dopamine_-_r47
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 305
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 308
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 307
left: DAT
left: Na+
left: dopamine
interaction type: HETERODIMER_ASSOCIATION
right: Complex (DAT/dopamine)

STATE_TRANSITION_LEFT__Mg2_PLUS_-_dopamine-RIGHT__Mg2_PLUS_-_a30_degraded-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 341
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 339
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 340
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 342
left: Mg2+
left: dopamine
interaction type: STATE_TRANSITION
right: Mg2+
right: a30_degraded

SNARE
type: Protein
entity reference: SNARE
cellular location: dense core granule
comment: SPECIES_TYPE=PROTEIN

uniprot H2QLA1 179
type: UnificationXref
id: H2QLA1
db: uniprot

P00061
type: UnificationXref
id: P00061
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r34 288
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

uniprot F1LNR9 57
type: UnificationXref
id: F1LNR9
db: uniprot

Complex (VAT1/epinephrine)
type: Complex
component stoichiometry: epinephrine s15 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: VAT1 s13 sa3 STOICHIOMETRY ID COMPLEX
component: VAT1
component: epinephrine
feature: COMPLEX BINDING FEATURE s50 a55 269
feature: COMPLEX BINDING FEATURE s50 a55 271
cellular location: dense core granule

PARTICIPANT STOICHIOMETRY r34 287
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

Bos taurus
type: BioSource
xref: ncbitaxon 9913 26

uniprot A0A1D5RJP1 35
type: UnificationXref
id: A0A1D5RJP1
db: uniprot

P00066
type: UnificationXref
id: P00066
db: PANTHER Pathway Component

P00067
type: UnificationXref
id: P00067
db: PANTHER Pathway Component

uniprot Q9W1I8 243
type: UnificationXref
id: Q9W1I8
db: uniprot

Syntaxin-12
type: ProteinReference
xref: uniprot G3V7P1 174
xref: PTHR19957:SF88
organism: Rattus norvegicus

P00068
type: UnificationXref
id: P00068
db: PANTHER Pathway Component

DISSOCIATION_LEFT__Complex__NET_norepinephrine_-RIGHT__norepinephrine-_NET-_Na_PLUS_-_r41
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 327
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 328
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 330
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 329
left: Complex (NET/norepinephrine)
interaction type: DISSOCIATION
right: norepinephrine
right: Na+
right: NET

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 15

P00069
type: UnificationXref
id: P00069
db: PANTHER Pathway Component

P00062
type: UnificationXref
id: P00062
db: PANTHER Pathway Component

P00063
type: UnificationXref
id: P00063
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_r3
controller: TH

P00064
type: UnificationXref
id: P00064
db: PANTHER Pathway Component

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 171

P00065
type: UnificationXref
id: P00065
db: PANTHER Pathway Component

Protein CBR-SYX-7
type: ProteinReference
xref: PTHR19957:SF38
xref: uniprot A8XFD7 161
organism: Caenorhabditis briggsae

uniprot Q9ERB0 235
type: UnificationXref
id: Q9ERB0
db: uniprot

Amine oxidase
type: ProteinReference
xref: PTHR43563:SF5
xref: uniprot A0A140T837 122
organism: Bos taurus

HETERODIMER_ASSOCIATION_LEFT__VAT1-_epinephrine-RIGHT__Complex__VAT1_epinephrine_-_r37
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 283
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 281
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 282
left: epinephrine
left: VAT1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (VAT1/epinephrine)

uniprot F1PRG8 163
type: UnificationXref
id: F1PRG8
db: uniprot

DBH
type: Protein
entity reference: DBH
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A8XFD7 161
type: UnificationXref
id: A8XFD7
db: uniprot

uniprot Q2KJD2 215
type: UnificationXref
id: Q2KJD2
db: uniprot

P00071
type: UnificationXref
id: P00071
db: PANTHER Pathway Component

P00072
type: UnificationXref
id: P00072
db: PANTHER Pathway Component

Transporter
type: ProteinReference
xref: PTHR11616:SF101
xref: uniprot E2R9L9 90
organism: Canis lupus familiaris

P00070
type: UnificationXref
id: P00070
db: PANTHER Pathway Component

uniprot H2QY46 46
type: UnificationXref
id: H2QY46
db: uniprot

Transporter
type: ProteinReference
xref: PTHR11616:SF282
xref: uniprot B7Z122 89
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r46 312
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot O95721 192
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r46 311
type: Stoichiometry
physical entity: Complex (VAT2/DOPA)
stoichiometric coefficient: 1.0

DOPA decarb.
type: Protein
entity reference: DOPA decarb.
cellular location: dense core granule
comment: SPECIES_TYPE=PROTEIN

uniprot F1PFF8 123
type: UnificationXref
id: F1PFF8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__epinephrine-_Mg2_PLUS_-RIGHT__Mg2_PLUS_-_a16_degraded-_r17
controller: COMT

PTHR45701:SF18
type: RelationshipXref
id: PTHR45701:SF18
db: PANTHER Family
relationship type: By Homology

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: uniprot P51143 60
xref: PTHR11616:SF245
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r46 313
type: Stoichiometry
physical entity: VAT2
stoichiometric coefficient: 1.0

uniprot Q7Z0T4 228
type: UnificationXref
id: Q7Z0T4
db: uniprot

uniprot H2QYH5 126
type: UnificationXref
id: H2QYH5
db: uniprot

Putative syntaxin-24
type: ProteinReference
xref: uniprot Q9C615 233
organism: Arabidopsis thaliana

DOPA
type: SmallMolecule
cellular location: dense core granule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Inactive sodium-dependent neutral amino acid transporter B(0)AT3
type: ProteinReference
xref: PTHR11616:SF109
xref: uniprot Q96N87 115
organism: Homo sapiens

VAT1
type: ProteinReference
xref: P00071
standard name: Chromaffin granule amine transporter
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Chromaffin granule amine transporter Synonym: VAT1,Vesicular amine transporter 1 Accession: P00071
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.VAT1
member entity reference: Synaptic vesicular amine transporter
member entity reference: Uncharacterized protein
member entity reference: GH10249p
member entity reference: SLC18A2 isoform 1
member entity reference: Chromaffin granule amine transporter
member entity reference: Solute carrier family 18 (Vesicular monoamine), member 2
member entity reference: SLC18A1 isoform 2

DISSOCIATION
type: RelationshipTypeVocabulary

a15_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

Na+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa54 268
cellular location: cytosol
comment: SPECIES_TYPE=ION

Dopamine beta-hydroxylase
type: ProteinReference
xref: uniprot P15101 48
xref: PTHR10157:SF29
organism: Bos taurus

DOPA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 56

Amine oxidase [flavin-containing] B
type: ProteinReference
xref: PTHR43563:SF5
xref: uniprot P19643 128
organism: Rattus norvegicus

PTHR11999:SF70
type: RelationshipXref
id: PTHR11999:SF70
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__epinephrine-_amine_translocator-RIGHT__Complex__amine_translocator_epinephrine_-_r42
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 324
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 322
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 323
left: epinephrine
left: amine translocator
interaction type: HETERODIMER_ASSOCIATION
right: Complex (amine translocator/epinephrine)

uniprot Q9XS59 121
type: UnificationXref
id: Q9XS59
db: uniprot

Catechol O-methyltransferase
type: ProteinReference
xref: PTHR43836:SF3
xref: uniprot O88587 139
organism: Mus musculus

Amine oxidase [flavin-containing] B
type: ProteinReference
xref: PTHR43563:SF5
xref: uniprot Q8BW75 136
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r39 277
type: Stoichiometry
physical entity: VAT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r39 276
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

Mg2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

PARTICIPANT STOICHIOMETRY r39 275
type: Stoichiometry
physical entity: Complex (VAT1/norepinephrine)
stoichiometric coefficient: 1.0

DOPA decarb.
type: ProteinReference
xref: P00066
standard name: Aromatic L-amino acid decarboxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Aromatic L-amino acid decarboxylase Synonym: DOPA decarboxylase Accession: P00066
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.DOPA decarb.
member entity reference: AGAP009091-PA
member entity reference: Aromatic-L-amino-acid decarboxylase
member entity reference: Probable aromatic-L-amino-acid decarboxylase
member entity reference: Os10g0380800 protein
member entity reference: Ddc protein
member entity reference: Probable tyrosine decarboxylase 2
member entity reference: MIP05841p
member entity reference: Dopa decarboxylase
member entity reference: Protein CBR-BAS-1
member entity reference: Biogenic Amine Synthesis related

uniprot Q695T7 109
type: UnificationXref
id: Q695T7
db: uniprot

Vesicle transport through interaction with t-SNAREs homolog 1B
type: ProteinReference
xref: uniprot O88384 191
xref: PTHR21230:SF79
organism: Mus musculus

Sodium- and chloride-dependent transporter XTRP3A
type: ProteinReference
xref: PTHR11616:SF44
xref: uniprot Q8VDB9 114
organism: Mus musculus

uniprot P63024 205
type: UnificationXref
id: P63024
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 53

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

VAT2
type: Protein
entity reference: VAT2
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa9 250
cellular location: dense core granule
comment: SPECIES_TYPE=PROTEIN

DBH isoform 1
type: ProteinReference
xref: PTHR10157:SF29
xref: uniprot H2QY46 46
organism: Pan troglodytes

uniprot A5PMJ7 158
type: UnificationXref
id: A5PMJ7
db: uniprot

uniprot P21396 129
type: UnificationXref
id: P21396
db: uniprot

Syntaxin-7
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot F7ATP9 168
organism: Macaca mulatta

PTHR10867:SF18
type: RelationshipXref
id: PTHR10867:SF18
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9544 15
type: UnificationXref
id: 9544
db: ncbitaxon

ncbitaxon 7165 80
type: UnificationXref
id: 7165
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r29 337
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

norepinephrine s12 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

ncbitaxon 559292 196
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot P10938 25
type: UnificationXref
id: P10938
db: uniprot

PARTICIPANT STOICHIOMETRY r29 338
type: Stoichiometry
physical entity: dopamine
stoichiometric coefficient: 1.0

uniprot A0A2I3TP36 66
type: UnificationXref
id: A0A2I3TP36
db: uniprot

uniprot P23763 194
type: UnificationXref
id: P23763
db: uniprot

uniprot Q7G6M2 77
type: UnificationXref
id: Q7G6M2
db: uniprot

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 239
organism: Arabidopsis thaliana

Vesicle transport through interaction with t-SNAREs 1B
type: ProteinReference
xref: PTHR21230:SF64
xref: uniprot H2Q8H8 177
organism: Pan troglodytes

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q9VH76 242
xref: PTHR19305:SF14
organism: Drosophila melanogaster

uniprot Q92356 231
type: UnificationXref
id: Q92356
db: uniprot

uniprot A0A1D5QYR9 156
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

Transporter
type: ProteinReference
xref: uniprot F1LNR9 57
xref: PTHR11616:SF245
organism: Rattus norvegicus

DOPA
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa10 252
cellular location: dense core granule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Synaptobrevin-A
type: ProteinReference
xref: PTHR45701:SF18
xref: uniprot Q6TMJ9 223
organism: Dictyostelium discoideum

STATE_TRANSITION
type: RelationshipTypeVocabulary

dopamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa12 266
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2QCU9 16
type: UnificationXref
id: H2QCU9
db: uniprot

Solute carrier family 18 (Vesicular monoamine), member 2
type: ProteinReference
xref: uniprot B0JYP2 143
xref: PTHR23506:SF30
organism: Bos taurus

COMT
type: ProteinReference
xref: P00069
standard name: Catechol-O-Methyl Transferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Catechol-O-Methyl Transferase Synonym: COMT Accession: P00069
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.COMT
member entity reference: Catechol O-methyltransferase
member entity reference: COMT isoform 1
member entity reference: Catechol O-methyltransferase isoform MB-COMT

PTHR19957:SF88
type: RelationshipXref
id: PTHR19957:SF88
db: PANTHER Family
relationship type: By Homology

uniprot P22734 141
type: UnificationXref
id: P22734
db: uniprot

uniprot P58027 133
type: UnificationXref
id: P58027
db: uniprot

uniprot H2PYG1 176
type: UnificationXref
id: H2PYG1
db: uniprot

uniprot A8X844 68
type: UnificationXref
id: A8X844
db: uniprot

Ddc protein
type: ProteinReference
xref: uniprot Q7SZR0 81
xref: PTHR11999:SF70
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__DOPA-RIGHT__dopamine-_r29
controller: DOPA decarb.

ncbitaxon 9913 26
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot Q39233 216
type: UnificationXref
id: Q39233
db: uniprot

TH isoform 6
type: ProteinReference
xref: uniprot H2Q2W7 36
xref: PTHR11473:SF18
organism: Pan troglodytes

Soluble NSF attachment protein 29
type: ProteinReference
xref: uniprot P83351 209
xref: PTHR19305:SF9
organism: Caenorhabditis elegans

PANTHER Pathway P00001 1
type: UnificationXref
id: P00001
db: PANTHER Pathway

uniprot Q9M0G4 82
type: UnificationXref
id: Q9M0G4
db: uniprot

PARTICIPANT STOICHIOMETRY r42 324
type: Stoichiometry
physical entity: Complex (amine translocator/epinephrine)
stoichiometric coefficient: 1.0

uniprot O88576 104
type: UnificationXref
id: O88576
db: uniprot

PARTICIPANT STOICHIOMETRY r26 339
type: Stoichiometry
physical entity: Mg2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r42 322
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

uniprot P11086 27
type: UnificationXref
id: P11086
db: uniprot

PARTICIPANT STOICHIOMETRY r42 323
type: Stoichiometry
physical entity: amine translocator
stoichiometric coefficient: 1.0

STX7 isoform 4
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot H2QTR3 180
organism: Pan troglodytes

Amine N-MethylTransferase
type: ProteinReference
xref: uniprot Q20308 33
organism: Caenorhabditis elegans

PTHR19957:SF90
type: RelationshipXref
id: PTHR19957:SF90
db: PANTHER Family
relationship type: By Homology

uniprot P40936 32
type: UnificationXref
id: P40936
db: uniprot

uniprot P20711 75
type: UnificationXref
id: P20711
db: uniprot

Catechol O-methyltransferase isoform MB-COMT
type: ProteinReference
xref: PTHR43836:SF3
xref: uniprot F6QFW9 137
organism: Macaca mulatta

uniprot Q86Y82 230
type: UnificationXref
id: Q86Y82
db: uniprot

PARTICIPANT STOICHIOMETRY r26 340
type: Stoichiometry
physical entity: dopamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 341
type: Stoichiometry
physical entity: Mg2+
stoichiometric coefficient: 1.0

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: PTHR43563:SF11
xref: uniprot P21396 129
organism: Rattus norvegicus

uniprot Q01818 151
type: UnificationXref
id: Q01818
db: uniprot

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: PTHR43563:SF11
xref: uniprot P21397 130
organism: Homo sapiens

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: PTHR43563:SF11
xref: uniprot P21398 131
organism: Bos taurus

uniprot A0A1D5QT69 142
type: UnificationXref
id: A0A1D5QT69
db: uniprot

Nicotinamide N-methyltransferase
type: ProteinReference
xref: uniprot P40261 30
organism: Homo sapiens

uniprot F7F542 95
type: UnificationXref
id: F7F542
db: uniprot

Transporter
type: ProteinReference
xref: PTHR11616:SF109
xref: uniprot F7GJ70 96
organism: Macaca mulatta

uniprot O88587 139
type: UnificationXref
id: O88587
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__norepinephrine-RIGHT__epinephrine-_r31
controller: PNMT

PARTICIPANT STOICHIOMETRY r26 342
type: Stoichiometry
physical entity: a30_degraded
stoichiometric coefficient: 1.0

epinephrine s15 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 69

STATE_TRANSITION_LEFT__norepinephrine-RIGHT__epinephrine-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 290
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 289
left: norepinephrine
interaction type: STATE_TRANSITION
right: epinephrine

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 29

ncbitaxon 6238 69
type: UnificationXref
id: 6238
db: ncbitaxon

Syntaxin-21
type: ProteinReference
xref: uniprot Q39233 216
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r41 330
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

Na+
type: SmallMolecule
comment: SPECIES_TYPE=ION

dense core granule
type: CellularLocationVocabulary
xref: GO GO:0031045 2

ncbitaxon 7227 41
type: UnificationXref
id: 7227
db: ncbitaxon

PTHR43563:SF5
type: RelationshipXref
id: PTHR43563:SF5
db: PANTHER Family
relationship type: By Homology

Transporter
type: ProteinReference
xref: PTHR11616:SF125
xref: uniprot F7GJ89 97
organism: Macaca mulatta

uniprot F6QFW9 137
type: UnificationXref
id: F6QFW9
db: uniprot

Transporter
type: ProteinReference
xref: uniprot A0A2J8MWT0 54
xref: PTHR11616:SF245
organism: Pan troglodytes

uniprot O88533 72
type: UnificationXref
id: O88533
db: uniprot

uniprot A0A2J8KI57 148
type: UnificationXref
id: A0A2J8KI57
db: uniprot

uniprot Q8BJI1 113
type: UnificationXref
id: Q8BJI1
db: uniprot

uniprot F7CT33 62
type: UnificationXref
id: F7CT33
db: uniprot

PARTICIPANT STOICHIOMETRY r41 329
type: Stoichiometry
physical entity: NET
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 328
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 327
type: Stoichiometry
physical entity: Complex (NET/norepinephrine)
stoichiometric coefficient: 1.0

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 78

uniprot E2R4Q2 162
type: UnificationXref
id: E2R4Q2
db: uniprot

uniprot F6XYX9 167
type: UnificationXref
id: F6XYX9
db: uniprot

Sodium- and chloride-dependent transporter XTRP3
type: ProteinReference
xref: PTHR11616:SF44
xref: uniprot Q64093 108
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__norepinephrine-RIGHT__norepinephrine-_r11
control type: ACTIVATION
controller: SNARE

PARTICIPANT STOICHIOMETRY r30 291
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r30 292
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

uniprot O88575 103
type: UnificationXref
id: O88575
db: uniprot

uniprot Q01827 145
type: UnificationXref
id: Q01827
db: uniprot

Complex (VAT1/norepinephrine)
type: Complex
component stoichiometry: norepinephrine s12 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: VAT1 s9 sa1 STOICHIOMETRY ID COMPLEX
component: VAT1
component: norepinephrine
feature: COMPLEX BINDING FEATURE s48 a53 261
feature: COMPLEX BINDING FEATURE s48 a53 259
cellular location: dense core granule

uniprot P36975 199
type: UnificationXref
id: P36975
db: uniprot

uniprot Q9LMG8 236
type: UnificationXref
id: Q9LMG8
db: uniprot

a16_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

Dopamine beta-hydroxylase
type: ProteinReference
xref: PTHR10157:SF29
xref: uniprot P09172 47
organism: Homo sapiens

uniprot P19643 128
type: UnificationXref
id: P19643
db: uniprot

uniprot F7ERX8 14
type: UnificationXref
id: F7ERX8
db: uniprot

VAT1 s13 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VAT1
stoichiometric coefficient: 1.0

Synaptobrevin
type: ProteinReference
xref: PTHR45701:SF10
xref: uniprot P18489 193
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__epinephrine-_Mg2_PLUS_-RIGHT__Mg2_PLUS_-_a16_degraded-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 301
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 304
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 303
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 302
left: epinephrine
left: Mg2+
interaction type: STATE_TRANSITION
right: a16_degraded
right: Mg2+

uniprot Q6PBA3 110
type: UnificationXref
id: Q6PBA3
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 240
organism: Arabidopsis thaliana

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__epinephrine-RIGHT__epinephrine-_r34
control type: ACTIVATION
controller: SNARE

Chromaffin granule amine transporter
type: ProteinReference
xref: PTHR23506:SF31
xref: uniprot P54219 150
organism: Homo sapiens

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 80

Transporter
type: ProteinReference
xref: uniprot F6WWA2 91
xref: PTHR11616:SF125
organism: Xenopus tropicalis

uniprot O88384 191
type: UnificationXref
id: O88384
db: uniprot

Complex (amine translocator/epinephrine)
type: Complex
component stoichiometry: amine translocator s60 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: epinephrine s30 sa8 STOICHIOMETRY ID COMPLEX
component: amine translocator
component: epinephrine
feature: COMPLEX BINDING FEATURE s54 a62 247
feature: COMPLEX BINDING FEATURE s54 a62 245
cellular location: cytosol

uniprot Q6TMJ9 223
type: UnificationXref
id: Q6TMJ9
db: uniprot

uniprot H2QYH6 127
type: UnificationXref
id: H2QYH6
db: uniprot

uniprot F6UFJ7 165
type: UnificationXref
id: F6UFJ7
db: uniprot

DISSOCIATION_LEFT__Complex__VAT2_DOPA_-RIGHT__DOPA-_VAT2-_r46
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 311
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 313
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 312
left: Complex (VAT2/DOPA)
interaction type: DISSOCIATION
right: DOPA
right: VAT2

Indolethylamine N-methyltransferase
type: ProteinReference
xref: uniprot D3ZNJ5 6
organism: Rattus norvegicus

SYntaXin
type: ProteinReference
xref: PTHR19957:SF38
xref: uniprot O62236 188
organism: Caenorhabditis elegans

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot P14173 74
xref: PTHR11999:SF70
organism: Rattus norvegicus

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5TZ66 219
organism: Danio rerio

uniprot O55192 58
type: UnificationXref
id: O55192
db: uniprot

PARTICIPANT STOICHIOMETRY r5 320
type: Stoichiometry
physical entity: dopamine
stoichiometric coefficient: 1.0

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot P05031 73
xref: PTHR11999:SF70
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r5 321
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A5PEW5 157
xref: PTHR19305:SF14
organism: Caenorhabditis elegans

uniprot A0A2I3SQC1 86
type: UnificationXref
id: A0A2I3SQC1
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A8X8S6 160
xref: PTHR19305:SF14
organism: Caenorhabditis briggsae

uniprot F6YFA4 11
type: UnificationXref
id: F6YFA4
db: uniprot

Tyrosine hydroxylase 2
type: ProteinReference
xref: uniprot Q1LWZ5 44
xref: PTHR11473:SF19
organism: Danio rerio

uniprot P40935 31
type: UnificationXref
id: P40935
db: uniprot

PTHR11616:SF125
type: RelationshipXref
id: PTHR11616:SF125
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r43 317
type: Stoichiometry
physical entity: Complex (amine translocator/epinephrine)
stoichiometric coefficient: 1.0

dopamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r43 319
type: Stoichiometry
physical entity: amine translocator
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r43 318
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

Transporter
type: ProteinReference
xref: uniprot B6F0U1 55
xref: PTHR11616:SF245
organism: Canis lupus familiaris

uniprot Q9GZN6 117
type: UnificationXref
id: Q9GZN6
db: uniprot

Phenylethanolamine N-methyltransferase
type: ProteinReference
xref: uniprot P40935 31
xref: PTHR10867:SF18
organism: Mus musculus

Indolethylamine N-methyltransferase
type: ProteinReference
xref: uniprot P40936 32
organism: Mus musculus

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q63666 221
organism: Rattus norvegicus

PTHR11616:SF109
type: RelationshipXref
id: PTHR11616:SF109
db: PANTHER Family
relationship type: By Homology

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 229

uniprot P54219 150
type: UnificationXref
id: P54219
db: uniprot

PARTICIPANT STOICHIOMETRY r45 315
type: Stoichiometry
physical entity: VAT2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 314
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 17

uniprot F7E1T5 173
type: UnificationXref
id: F7E1T5
db: uniprot

uniprot P60879 203
type: UnificationXref
id: P60879
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q7SZZ5 227
xref: PTHR45701:SF5
organism: Danio rerio

uniprot Q63666 221
type: UnificationXref
id: Q63666
db: uniprot

uniprot Q6NSN2 135
type: UnificationXref
id: Q6NSN2
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot F6UBJ8 164
organism: Xenopus tropicalis

uniprot Q64237 50
type: UnificationXref
id: Q64237
db: uniprot

PARTICIPANT STOICHIOMETRY r45 316
type: Stoichiometry
physical entity: Complex (VAT2/DOPA)
stoichiometric coefficient: 1.0

Synaptobrevin homolog 2
type: ProteinReference
xref: PTHR45701:SF9
xref: uniprot P33328 198
organism: Saccharomyces cerevisiae

uniprot O04378 184
type: UnificationXref
id: O04378
db: uniprot

Syntaxin 7-like
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot A0A0A0MPL4 155
organism: Danio rerio

epinephrine
type: SmallMolecule
cellular location: dense core granule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

epinephrine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa4 272
cellular location: dense core granule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8BRU6 147
type: UnificationXref
id: Q8BRU6
db: uniprot

PTHR11616:SF113
type: RelationshipXref
id: PTHR11616:SF113
db: PANTHER Family
relationship type: By Homology

Complex (VAT2/DOPA)
type: Complex
component stoichiometry: DOPA s34 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: VAT2 s33 sa9 STOICHIOMETRY ID COMPLEX
component: DOPA
component: VAT2
feature: COMPLEX BINDING FEATURE s56 a65 251
feature: COMPLEX BINDING FEATURE s56 a65 249
cellular location: dense core granule

uniprot P63026 207
type: UnificationXref
id: P63026
db: uniprot

Syntaxin 12
type: ProteinReference
xref: PTHR19957:SF88
xref: uniprot A5PMJ7 158
organism: Danio rerio

uniprot Q8BW75 136
type: UnificationXref
id: Q8BW75
db: uniprot

uniprot O15400 185
type: UnificationXref
id: O15400
db: uniprot

PARTICIPANT STOICHIOMETRY r11 326
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

PTHR21136:SF168
type: RelationshipXref
id: PTHR21136:SF168
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r11 325
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 93

Syntaxin PEP12
type: ProteinReference
xref: uniprot P32854 197
organism: Saccharomyces cerevisiae

DAT
type: ProteinReference
xref: P00065
standard name: Sodium-dependent dopamine transporter
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.DAT
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Sodium-dependent dopamine transporter Synonym: DA transporter,DAT Accession: P00065
member entity reference: Sodium-dependent dopamine transporter
member entity reference: Transporter

uniprot O95050 23
type: UnificationXref
id: O95050
db: uniprot

PARTICIPANT STOICHIOMETRY r47 308
type: Stoichiometry
physical entity: Complex (DAT/dopamine)
stoichiometric coefficient: 1.0

ncbitaxon 7955 10
type: UnificationXref
id: 7955
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r47 307
type: Stoichiometry
physical entity: DAT
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot F7E0Z1 172
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r47 305
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r47 306
type: Stoichiometry
physical entity: dopamine
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__norepinephrine-RIGHT__norepinephrine-_r11
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 325
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 326
left: norepinephrine
interaction type: TRANSPORT
right: norepinephrine

a30_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

PTHR11473:SF15
type: RelationshipXref
id: PTHR11473:SF15
db: PANTHER Family
relationship type: By Homology

TH
type: ProteinReference
xref: P00062
standard name: Tyrosine Hydroxylase
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.TH
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Tyrosine Hydroxylase Synonym: TH Accession: P00062
member entity reference: Tyrosine 3-monooxygenase
member entity reference: TH isoform 6
member entity reference: Tyrosine hydroxylase 2
member entity reference: Uncharacterized protein

eco ECO:0000305 85
type: UnificationXref
id: ECO:0000305
db: eco

Vesicle transport through interaction with t-SNAREs 1B
type: ProteinReference
xref: PTHR21230:SF79
xref: uniprot J9NYA0 182
organism: Canis lupus familiaris

Na+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa55 258
cellular location: cytosol
comment: SPECIES_TYPE=ION

PTHR11473:SF19
type: RelationshipXref
id: PTHR11473:SF19
db: PANTHER Family
relationship type: By Homology

PTHR11473:SF18
type: RelationshipXref
id: PTHR11473:SF18
db: PANTHER Family
relationship type: By Homology

PTHR43836:SF3
type: RelationshipXref
id: PTHR43836:SF3
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O00161 183
organism: Homo sapiens

ncbitaxon 9031 53
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot P32854 197
type: UnificationXref
id: P32854
db: uniprot

PTHR11616:SF38
type: RelationshipXref
id: PTHR11616:SF38
db: PANTHER Family
relationship type: By Homology

PTHR11616:SF102
type: RelationshipXref
id: PTHR11616:SF102
db: PANTHER Family
relationship type: By Homology

uniprot F7B2G1 94
type: UnificationXref
id: F7B2G1
db: uniprot

PTHR11616:SF101
type: RelationshipXref
id: PTHR11616:SF101
db: PANTHER Family
relationship type: By Homology

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 232

Tyramine beta-hydroxylase
type: ProteinReference
xref: uniprot Q86B61 51
xref: PTHR10157:SF29
organism: Drosophila melanogaster

amine translocator
type: Protein
entity reference: amine translocator
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa7 246
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P33328 198
type: UnificationXref
id: P33328
db: uniprot

PNMT
type: ProteinReference
xref: P00061
standard name: Phenylethanolamine-N-methyltransferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phenylethanolamine-N-methyltransferase Synonym: PNMT Accession: P00061
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.PNMT
member entity reference: Nicotinamide N-methyltransferase
member entity reference: Zgc:64002
member entity reference: Indolethylamine N-methyltransferase
member entity reference: Uncharacterized protein
member entity reference: Uncharacterized LOC100145174
member entity reference: PNMT isoform 1
member entity reference: Phenylethanolamine N-methyltransferase
member entity reference: NNMT isoform 1
member entity reference: Amine N-MethylTransferase

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__DOPA-RIGHT__DOPA-_r30
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 291
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 292
left: DOPA
interaction type: TRANSPORT
right: DOPA

Vesicle transport through interaction with t-SNAREs homolog 1B
type: ProteinReference
xref: PTHR21230:SF79
xref: uniprot Q2KIU0 214
organism: Bos taurus

uniprot O62236 188
type: UnificationXref
id: O62236
db: uniprot

uniprot Q9H1V8 118
type: UnificationXref
id: Q9H1V8
db: uniprot

AGAP005543-PA
type: ProteinReference
xref: PTHR19957:SF38
xref: uniprot Q7PNQ5 226
organism: Anopheles gambiae

Na PLUS s62 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

PTHR11616:SF44
type: RelationshipXref
id: PTHR11616:SF44
db: PANTHER Family
relationship type: By Homology

Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
type: ProteinReference
xref: uniprot Q9GZN6 117
xref: PTHR11616:SF113
organism: Homo sapiens

uniprot P21397 130
type: UnificationXref
id: P21397
db: uniprot

Vesicle associated membrane protein 1
type: ProteinReference
xref: uniprot F1PRG8 163
xref: PTHR45701:SF1
organism: Canis lupus familiaris

Transporter
type: ProteinReference
xref: PTHR11616:SF102
xref: uniprot G7MIF5 98
organism: Macaca mulatta

uniprot P40261 30
type: UnificationXref
id: P40261
db: uniprot

Probable tyrosine decarboxylase 2
type: ProteinReference
xref: uniprot Q9M0G4 82
organism: Arabidopsis thaliana

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

Os01g0254900 protein
type: ProteinReference
xref: uniprot Q9S7H0 238
organism: Oryza sativa

uniprot Q9H2J7 119
type: UnificationXref
id: Q9H2J7
db: uniprot

uniprot F6WZU5 92
type: UnificationXref
id: F6WZU5
db: uniprot

uniprot P51143 60
type: UnificationXref
id: P51143
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9ERB0 235
xref: PTHR19305:SF9
organism: Mus musculus

Protein CBR-BAS-1
type: ProteinReference
xref: uniprot A8X844 68
xref: PTHR11999:SF70
organism: Caenorhabditis briggsae

DISSOCIATION_LEFT__Complex__amine_translocator_epinephrine_-RIGHT__epinephrine-_amine_translocator-_r43
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 317
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 319
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 318
left: Complex (amine translocator/epinephrine)
interaction type: DISSOCIATION
right: epinephrine
right: amine translocator

uniprot P17289 39
type: UnificationXref
id: P17289
db: uniprot

Syntaxin 7
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot E2R4Q2 162
organism: Canis lupus familiaris

Vesicle transport through interaction with t-SNAREs homolog 1B
type: ProteinReference
xref: uniprot P58200 200
xref: PTHR21230:SF79
organism: Rattus norvegicus

uniprot F7GJ70 96
type: UnificationXref
id: F7GJ70
db: uniprot

uniprot A0A140T837 122
type: UnificationXref
id: A0A140T837
db: uniprot

PARTICIPANT STOICHIOMETRY r48 300
type: Stoichiometry
physical entity: DAT
stoichiometric coefficient: 1.0

uniprot P60878 202
type: UnificationXref
id: P60878
db: uniprot

NET
type: Protein
entity reference: NET
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa5 254
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7668 187
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot H2R3L2 101
type: UnificationXref
id: H2R3L2
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 24

dopamine
type: SmallMolecule
cellular location: dense core granule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7FNE2 149
type: UnificationXref
id: F7FNE2
db: uniprot

Indolethylamine N-methyltransferase
type: ProteinReference
xref: uniprot O95050 23
organism: Homo sapiens

uniprot H2Q2W7 36
type: UnificationXref
id: H2Q2W7
db: uniprot

VAT1
type: Protein
entity reference: VAT1
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa1 260
cellular location: dense core granule
comment: SPECIES_TYPE=PROTEIN

uniprot Q05940 146
type: UnificationXref
id: Q05940
db: uniprot

Transporter
type: ProteinReference
xref: PTHR11616:SF245
xref: uniprot Q9MYW8 61
organism: Macaca mulatta

Transporter
type: ProteinReference
xref: uniprot H2QGU3 100
xref: PTHR11616:SF113
organism: Pan troglodytes

Sodium-dependent noradrenaline transporter
type: ProteinReference
xref: uniprot O55192 58
xref: PTHR11616:SF245
organism: Mus musculus

Amine oxidase
type: ProteinReference
xref: uniprot F1PFF8 123
xref: PTHR43563:SF5
organism: Canis lupus familiaris

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 83

uniprot F7ATP9 168
type: UnificationXref
id: F7ATP9
db: uniprot

Chromaffin granule amine transporter
type: ProteinReference
xref: PTHR23506:SF31
xref: uniprot Q8R090 153
organism: Mus musculus

Syntaxin-12
type: ProteinReference
xref: uniprot Q86Y82 230
xref: PTHR19957:SF88
organism: Homo sapiens

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q28HP6 213
xref: PTHR19305:SF5
organism: Xenopus tropicalis

DISSOCIATION_LEFT__Complex__VAT1_norepinephrine_-RIGHT__norepinephrine-_VAT1-_r39
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 276
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 277
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 275
left: Complex (VAT1/norepinephrine)
interaction type: DISSOCIATION
right: norepinephrine
right: VAT1

PTHR23506:SF30
type: RelationshipXref
id: PTHR23506:SF30
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF9
type: RelationshipXref
id: PTHR45701:SF9
db: PANTHER Family
relationship type: By Homology

PTHR23506:SF31
type: RelationshipXref
id: PTHR23506:SF31
db: PANTHER Family
relationship type: By Homology

uniprot Q9N0Y0 237
type: UnificationXref
id: Q9N0Y0
db: uniprot

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q7PSR4 111
type: UnificationXref
id: Q7PSR4
db: uniprot

uniprot O95721 192
type: UnificationXref
id: O95721
db: uniprot

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 187

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

Transporter (Fragment)
type: ProteinReference
xref: uniprot Q7PSR4 111
xref: PTHR11616:SF182
organism: Anopheles gambiae

uniprot Q8IH57 152
type: UnificationXref
id: Q8IH57
db: uniprot

PARTICIPANT STOICHIOMETRY r17 301
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

TH
type: Protein
entity reference: TH
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r17 302
type: Stoichiometry
physical entity: Mg2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r17 303
type: Stoichiometry
physical entity: Mg2+
stoichiometric coefficient: 1.0

uniprot Q5R1X1 218
type: UnificationXref
id: Q5R1X1
db: uniprot

NNMT isoform 1
type: ProteinReference
xref: uniprot A0A2J8KZX9 4
organism: Pan troglodytes

uniprot D4A605 8
type: UnificationXref
id: D4A605
db: uniprot

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: PTHR43563:SF11
xref: uniprot P58027 133
organism: Canis lupus familiaris

uniprot D3ZNJ5 6
type: UnificationXref
id: D3ZNJ5
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 10

uniprot P34254 28
type: UnificationXref
id: P34254
db: uniprot

uniprot H2Q6J9 99
type: UnificationXref
id: H2Q6J9
db: uniprot

Tyrosine 3-monooxygenase
type: ProteinReference
xref: PTHR11473:SF15
xref: uniprot P18459 40
organism: Drosophila melanogaster

DAT s38 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DAT
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ERX8 14
organism: Macaca mulatta

ncbitaxon 9615 56
type: UnificationXref
id: 9615
db: ncbitaxon

Sodium-dependent dopamine transporter
type: ProteinReference
xref: PTHR11616:SF38
xref: uniprot Q61327 65
organism: Mus musculus

uniprot A0A2J8MWT0 54
type: UnificationXref
id: A0A2J8MWT0
db: uniprot

STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 331
left: tyrosine
interaction type: STATE_TRANSITION
right: DOPA

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E1T5 173
xref: PTHR19957:SF88
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r17 304
type: Stoichiometry
physical entity: a16_degraded
stoichiometric coefficient: 1.0

Synaptobrevin homolog 1
type: ProteinReference
xref: PTHR45701:SF9
xref: uniprot P31109 195
organism: Saccharomyces cerevisiae

uniprot O70439 190
type: UnificationXref
id: O70439
db: uniprot

Sodium-dependent neutral amino acid transporter B(0)AT2
type: ProteinReference
xref: PTHR11616:SF101
xref: uniprot Q8BG16 112
organism: Mus musculus

uniprot B0JYP2 143
type: UnificationXref
id: B0JYP2
db: uniprot

uniprot O00161 183
type: UnificationXref
id: O00161
db: uniprot

PTHR21230:SF64
type: RelationshipXref
id: PTHR21230:SF64
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q17QQ3 212
organism: Bos taurus

uniprot H2QL91 138
type: UnificationXref
id: H2QL91
db: uniprot

uniprot Q2A865 106
type: UnificationXref
id: Q2A865
db: uniprot

uniprot Q9ER00 234
type: UnificationXref
id: Q9ER00
db: uniprot

uniprot P18459 40
type: UnificationXref
id: P18459
db: uniprot

Vesicle transport through interaction with t-SNAREs homolog 1B
type: ProteinReference
xref: uniprot Q9UEU0 241
xref: PTHR21230:SF64
organism: Homo sapiens

uniprot A0A1D5P472 52
type: UnificationXref
id: A0A1D5P472
db: uniprot

uniprot P93654 210
type: UnificationXref
id: P93654
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q9N0Y0 237
xref: PTHR45701:SF5
organism: Macaca mulatta

uniprot P83351 209
type: UnificationXref
id: P83351
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot P36975 199
organism: Drosophila melanogaster

dopamine
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

NET s23 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NET
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR23506:SF31
xref: uniprot F7FNE2 149
organism: Macaca mulatta

SNAP29 isoform 1
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot H2QLA1 179
organism: Pan troglodytes

Synaptic vesicular amine transporter
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot Q8BRU6 147
organism: Mus musculus

PTHR21230:SF79
type: RelationshipXref
id: PTHR21230:SF79
db: PANTHER Family
relationship type: By Homology

GH10249p
type: ProteinReference
xref: uniprot Q8IH57 152
organism: Drosophila melanogaster

uniprot P24529 42
type: UnificationXref
id: P24529
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 224

uniprot E2R9L9 90
type: UnificationXref
id: E2R9L9
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Tyrosine 3-monooxygenase
type: ProteinReference
xref: uniprot P17289 39
xref: PTHR11473:SF18
organism: Bos taurus

uniprot F6WWA2 91
type: UnificationXref
id: F6WWA2
db: uniprot

ncbitaxon 13616 93
type: UnificationXref
id: 13616
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9GNP0 154
organism: Caenorhabditis elegans

Sodium-dependent neutral amino acid transporter B(0)AT1
type: ProteinReference
xref: uniprot Q695T7 109
xref: PTHR11616:SF125
organism: Homo sapiens

uniprot H2Q8H8 177
type: UnificationXref
id: H2Q8H8
db: uniprot

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: uniprot Q6PC54 222
xref: PTHR19305:SF5
organism: Danio rerio

Transporter
type: ProteinReference
xref: PTHR11616:SF38
xref: uniprot F7CT33 62
organism: Macaca mulatta

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 85

DISSOCIATION_LEFT__Complex__VAT1_epinephrine_-RIGHT__VAT1-_epinephrine-_r38
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 280
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 279
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 278
left: Complex (VAT1/epinephrine)
interaction type: DISSOCIATION
right: epinephrine
right: VAT1

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot O44419 186
organism: Strongylocentrotus purpuratus

epinephrine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa8 248
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Syntaxin 7
type: ProteinReference
xref: uniprot F7E0A0 170
xref: PTHR19957:SF90
organism: Ornithorhynchus anatinus

Sodium-dependent dopamine transporter
type: ProteinReference
xref: uniprot P23977 63
xref: PTHR11616:SF38
organism: Rattus norvegicus

uniprot O45137 71
type: UnificationXref
id: O45137
db: uniprot

uniprot B6F0U1 55
type: UnificationXref
id: B6F0U1
db: uniprot

uniprot O70257 189
type: UnificationXref
id: O70257
db: uniprot

PTHR43563:SF11
type: RelationshipXref
id: PTHR43563:SF11
db: PANTHER Family
relationship type: By Homology

Amine oxidase
type: ProteinReference
xref: uniprot F6V922 124
xref: PTHR43563:SF5
organism: Xenopus tropicalis

uniprot Q9D687 116
type: UnificationXref
id: Q9D687
db: uniprot

DOPA s34 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

uniprot P23975 59
type: UnificationXref
id: P23975
db: uniprot

uniprot F7D3H3 125
type: UnificationXref
id: F7D3H3
db: uniprot

Transporter
type: ProteinReference
xref: PTHR11616:SF102
xref: uniprot A0A2I3SQC1 86
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r37 281
type: Stoichiometry
physical entity: VAT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 282
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 283
type: Stoichiometry
physical entity: Complex (VAT1/epinephrine)
stoichiometric coefficient: 1.0

Complex (DAT/dopamine)
type: Complex
component stoichiometry: DAT s38 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Na PLUS s62 sa54 STOICHIOMETRY ID COMPLEX
component stoichiometry: dopamine s39 sa12 STOICHIOMETRY ID COMPLEX
component: Na+
component: dopamine
component: DAT
feature: COMPLEX BINDING FEATURE s58 a68 265
feature: COMPLEX BINDING FEATURE s58 a68 267
feature: COMPLEX BINDING FEATURE s58 a68 263
cellular location: cytosol

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q62442 220
xref: PTHR45701:SF1
organism: Mus musculus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 7

PTHR11616:SF182
type: RelationshipXref
id: PTHR11616:SF182
db: PANTHER Family
relationship type: By Homology

epinephrine s30 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: epinephrine
stoichiometric coefficient: 1.0

norepinephrine
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

AGAP009091-PA
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot Q7PW49 79
organism: Anopheles gambiae

Sodium-dependent neutral amino acid transporter SLC6A17
type: ProteinReference
xref: PTHR11616:SF102
xref: uniprot Q9H1V8 118
organism: Homo sapiens

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Nicotinamide N-methyltransferase
type: ProteinReference
xref: uniprot D4A605 8
organism: Rattus norvegicus

uniprot Q8VDB9 114
type: UnificationXref
id: Q8VDB9
db: uniprot

uniprot Q7K0X9 225
type: UnificationXref
id: Q7K0X9
db: uniprot

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 175
organism: Caenorhabditis elegans

uniprot P90986 43
type: UnificationXref
id: P90986
db: uniprot

uniprot P14173 74
type: UnificationXref
id: P14173
db: uniprot

uniprot P05031 73
type: UnificationXref
id: P05031
db: uniprot

VAT1 s9 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VAT1
stoichiometric coefficient: 1.0

Syntaxin 7
type: ProteinReference
xref: uniprot F6VQZ5 166
xref: PTHR19957:SF90
organism: Xenopus tropicalis

VAT1
type: Protein
entity reference: VAT1
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa3 270
cellular location: dense core granule
comment: SPECIES_TYPE=PROTEIN

Biogenic Amine Synthesis related
type: ProteinReference
xref: uniprot O45137 71
xref: PTHR11999:SF70
organism: Caenorhabditis elegans

Indolethylamine N-methyltransferase
type: ProteinReference
xref: uniprot H2QUD4 19
organism: Pan troglodytes

NET
type: ProteinReference
xref: P00064
standard name: Norepinephrine transporter
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Norepinephrine transporter Synonym: NET,SLC6A2,Sodium-dependent noradrenaline transporter Accession: P00064
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.NET
member entity reference: Transporter
member entity reference: Sodium-dependent noradrenaline transporter

PARTICIPANT STOICHIOMETRY r48 297
type: Stoichiometry
physical entity: Complex (DAT/dopamine)
stoichiometric coefficient: 1.0

LD03592p
type: ProteinReference
xref: uniprot Q9W1I8 243
xref: PTHR19305:SF9
organism: Drosophila melanogaster

uniprot H2QTR3 180
type: UnificationXref
id: H2QTR3
db: uniprot

uniprot Q9UEU0 241
type: UnificationXref
id: Q9UEU0
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot P23763 194
xref: PTHR45701:SF1
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r48 298
type: Stoichiometry
physical entity: dopamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 299
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

PNMT
type: Protein
entity reference: PNMT
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__epinephrine-RIGHT__epinephrine-_r16
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 309
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 310
left: epinephrine
interaction type: TRANSPORT
right: epinephrine

uniprot F7HGF9 45
type: UnificationXref
id: F7HGF9
db: uniprot

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 236
organism: Arabidopsis thaliana

Na PLUS s63 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

Phenylethanolamine N-methyltransferase
type: ProteinReference
xref: PTHR10867:SF18
xref: uniprot P11086 27
organism: Homo sapiens

ncbitaxon 9598 5
type: UnificationXref
id: 9598
db: ncbitaxon

STATE_TRANSITION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY r36 284
type: Stoichiometry
physical entity: VAT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 285
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

Sodium-dependent neutral amino acid transporter B(0)AT1
type: ProteinReference
xref: uniprot Q2A865 106
xref: PTHR11616:SF125
organism: Rattus norvegicus

MAO
type: ProteinReference
xref: P00067
standard name: Monoamine Oxidase
comment: ENTITY_REFERENCE_NOTES=Long Name: Monoamine Oxidase Synonym: MAO Accession: P00067
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.MAO
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Amine oxidase [flavin-containing] B
member entity reference: Amine oxidase [flavin-containing]
member entity reference: Amine oxidase [flavin-containing] A
member entity reference: Amine oxidase

PARTICIPANT STOICHIOMETRY r36 286
type: Stoichiometry
physical entity: Complex (VAT1/norepinephrine)
stoichiometric coefficient: 1.0

TRANSPORT
type: InteractionVocabulary

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q0V7N0 211
xref: PTHR45701:SF1
organism: Bos taurus

SLC18A1 isoform 2
type: ProteinReference
xref: uniprot A0A2J8KI57 148
xref: PTHR23506:SF31
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10157:SF29
xref: uniprot F7HGF9 45
organism: Macaca mulatta

uniprot Q64133 134
type: UnificationXref
id: Q64133
db: uniprot

dopamine s39 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: dopamine
stoichiometric coefficient: 1.0

uniprot P04177 37
type: UnificationXref
id: P04177
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QT69 142
xref: PTHR23506:SF30
organism: Macaca mulatta

Amine N-MethylTransferase
type: ProteinReference
xref: uniprot Q22279 34
organism: Caenorhabditis elegans

uniprot P18489 193
type: UnificationXref
id: P18489
db: uniprot

uniprot O55239 21
type: UnificationXref
id: O55239
db: uniprot

STX12 isoform 1
type: ProteinReference
xref: uniprot H2PYG1 176
xref: PTHR19957:SF88
organism: Pan troglodytes

Sodium- and chloride-dependent transporter XTRP3
type: ProteinReference
xref: uniprot Q9NP91 120
xref: PTHR11616:SF44
organism: Homo sapiens

ncbitaxon 6239 29
type: UnificationXref
id: 6239
db: ncbitaxon

Transporter
type: ProteinReference
xref: PTHR11616:SF245
xref: uniprot A0A1D5P472 52
organism: Gallus gallus

VAT2
type: Protein
entity reference: VAT2
cellular location: dense core granule
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION_LEFT__Complex__DAT_dopamine_-RIGHT__dopamine-_Na_PLUS_-_DAT-_r48
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 297
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 298
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 300
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 299
left: Complex (DAT/dopamine)
interaction type: DISSOCIATION
right: DAT
right: Na+
right: dopamine

Tyrosine 3-monooxygenase
type: ProteinReference
xref: uniprot P07101 38
xref: PTHR11473:SF18
organism: Homo sapiens

PTHR19957:SF38
type: RelationshipXref
id: PTHR19957:SF38
db: PANTHER Family
relationship type: By Homology

MAO
type: Protein
entity reference: MAO
comment: SPECIES_TYPE=PROTEIN

Syntaxin-7
type: ProteinReference
xref: PTHR19957:SF90
xref: uniprot O15400 185
organism: Homo sapiens

uniprot P31109 195
type: UnificationXref
id: P31109
db: uniprot

TRANSPORT_LEFT__epinephrine-RIGHT__epinephrine-_r34
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 287
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 288
left: epinephrine
interaction type: TRANSPORT
right: epinephrine

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

DBH
type: ProteinReference
xref: P00063
standard name: Dopamine beta-hydroxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.DBH
comment: ENTITY_REFERENCE_NOTES=Long Name: Dopamine beta-hydroxylase Synonym: DA beta-hydroxylase,DBH,Dopamine beta-hydroxylase Accession: P00063
member entity reference: Dopamine beta-hydroxylase
member entity reference: Uncharacterized protein
member entity reference: DBH isoform 1
member entity reference: Tyramine beta-hydroxylase

uniprot A0A2J8KZX9 4
type: UnificationXref
id: A0A2J8KZX9
db: uniprot

uniprot P60880 204
type: UnificationXref
id: P60880
db: uniprot

uniprot P21964 140
type: UnificationXref
id: P21964
db: uniprot

uniprot Q62442 220
type: UnificationXref
id: Q62442
db: uniprot

uniprot P07101 38
type: UnificationXref
id: P07101
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot F7C233 169
type: UnificationXref
id: F7C233
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot H2Q995 178
organism: Pan troglodytes

norepinephrine s26 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

uniprot Q1LWZ5 44
type: UnificationXref
id: Q1LWZ5
db: uniprot

ncbitaxon 39947 78
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q9SD96 240
type: UnificationXref
id: Q9SD96
db: uniprot

PARTICIPANT STOICHIOMETRY r3 331
type: Stoichiometry
physical entity: tyrosine
stoichiometric coefficient: 1.0

uniprot Q01959 64
type: UnificationXref
id: Q01959
db: uniprot

PARTICIPANT STOICHIOMETRY r40 336
type: Stoichiometry
physical entity: Complex (NET/norepinephrine)
stoichiometric coefficient: 1.0

amine translocator
type: ProteinReference
xref: P00068
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Adrenaline and noradrenaline biosynthesis.PROTEIN.GENERIC.amine_br_translocator
member entity reference: Sodium- and chloride-dependent transporter XTRP3
member entity reference: Sodium-dependent neutral amino acid transporter SLC6A17
member entity reference: Sodium-dependent neutral amino acid transporter B(0)AT1
member entity reference: Transporter
member entity reference: Sodium-dependent neutral amino acid transporter B(0)AT2
member entity reference: Solute carrier family 6 member 18
member entity reference: Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
member entity reference: Inactive sodium-dependent neutral amino acid transporter B(0)AT3
member entity reference: Sodium- and chloride-dependent transporter XTRP3A
member entity reference: Sodium-dependent neutral amino acid transporter B(0)AT3
member entity reference: Sodium- and chloride-dependent transporter XTRP3B
member entity reference: Transporter (Fragment)

PARTICIPANT STOICHIOMETRY r40 335
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r40 334
type: Stoichiometry
physical entity: NET
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r40 333
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 332
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Na_PLUS_-_NET-_norepinephrine-RIGHT__Complex__NET_norepinephrine_-_r40
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 334
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 335
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 336
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 333
left: norepinephrine
left: Na+
left: NET
interaction type: HETERODIMER_ASSOCIATION
right: Complex (NET/norepinephrine)

Dopamine beta-hydroxylase
type: ProteinReference
xref: PTHR10157:SF29
xref: uniprot Q05754 49
organism: Rattus norvegicus

uniprot Q0V7N0 211
type: UnificationXref
id: Q0V7N0
db: uniprot

uniprot Q22279 34
type: UnificationXref
id: Q22279
db: uniprot

ncbitaxon 44689 224
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot Q86B61 51
type: UnificationXref
id: Q86B61
db: uniprot

uniprot F6VQZ5 166
type: UnificationXref
id: F6VQZ5
db: uniprot

STX12 protein
type: ProteinReference
xref: uniprot A7MAZ2 159
xref: PTHR19957:SF88
organism: Bos taurus

amine translocator
type: Protein
entity reference: amine translocator
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN