Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot A8XRA5 15
organism: Caenorhabditis briggsae

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__Adrenaline-RIGHT__Adrenaline-_r56
control type: ACTIVATION
controller: SNARE

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: uniprot M9PE71 82
xref: PTHR45701:SF3
organism: Drosophila melanogaster

uniprot P18825 177
type: UnificationXref
id: P18825
db: uniprot

PKC
type: Protein
entity reference: PKC
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=PROTEIN

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A0A1D5QYR9 63
xref: PTHR19305:SF4
organism: Macaca mulatta

uniprot F6TQN3 25
type: UnificationXref
id: F6TQN3
db: uniprot

ncbitaxon 13616 24
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot P60877 94
type: UnificationXref
id: P60877
db: uniprot

ncbitaxon 3702 125
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot F1PL90 19
type: UnificationXref
id: F1PL90
db: uniprot

Adrenoceptor alpha 1A
type: ProteinReference
xref: uniprot A0A2I3T596 168
xref: PTHR24248:SF16
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F6TQN3 25
organism: Monodelphis domestica

uniprot Q9P212 57
type: UnificationXref
id: Q9P212
db: uniprot

uniprot H9FVW1 34
type: UnificationXref
id: H9FVW1
db: uniprot

Muscle Contraction
type: Pathway

uniprot O60499 88
type: UnificationXref
id: O60499
db: uniprot

Syntaxin-6
type: ProteinReference
xref: PTHR19957:SF104
xref: uniprot Q5ZL19 115
organism: Gallus gallus

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 61
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=PROTEIN

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: G Protein s2 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s1 sa1 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-Protein
feature: COMPLEX BINDING FEATURE s59 a65 205
feature: ACTIVE 61
feature: COMPLEX BINDING FEATURE s59 a65 203
cellular location: smooth cardiac muscle, or neuron c2

uniprot F5HMB9 21
type: UnificationXref
id: F5HMB9
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 14

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6XYX9 72
organism: Monodelphis domestica

ncbitaxon 227321 111
type: UnificationXref
id: 227321
db: ncbitaxon

Syntaxin-6
type: ProteinReference
xref: PTHR19957:SF104
xref: uniprot O43752 85
organism: Homo sapiens

eco ECO:0000305 175
type: UnificationXref
id: ECO:0000305
db: eco

Adrenaline or NE
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa10 218
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P13217 43
type: UnificationXref
id: P13217
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 92

Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q5RKP9 165
organism: Danio rerio

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 44

uniprot Q7PW25 51
type: UnificationXref
id: Q7PW25
db: uniprot

uniprot Q9JID2 166
type: UnificationXref
id: Q9JID2
db: uniprot

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa4 190
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=PROTEIN

GDP s12 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot H9ZA60 35
organism: Macaca mulatta

uniprot A0A2I3SSC7 129
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot Q14643 137
xref: PTHR13715:SF52
organism: Homo sapiens

GDP s5 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__PIP2-RIGHT__DAG-_IP3-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 244
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 246
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 245
left: PIP2
interaction type: DISSOCIATION
right: IP3
right: DAG

NE
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9598 9
type: UnificationXref
id: 9598
db: ncbitaxon

ncbitaxon 3055 121
type: UnificationXref
id: 3055
db: ncbitaxon

uniprot O43752 85
type: UnificationXref
id: O43752
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot Q01970 49
organism: Homo sapiens

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P63318 153
xref: PTHR24356:SF162
organism: Mus musculus

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63319 154
organism: Rattus norvegicus

uniprot P63025 99
type: UnificationXref
id: P63025
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F6VHF7 132
xref: PTHR13715:SF52
organism: Xenopus tropicalis

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa7 196
cellular location: Nerve Fiber c5
comment: SPECIES_TYPE=PROTEIN

uniprot Q9JKK1 126
type: UnificationXref
id: Q9JKK1
db: uniprot

PIP2
type: SmallMolecule
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Adrenoceptor alpha 1B
type: ProteinReference
xref: uniprot F1MGA6 169
xref: PTHR24248:SF17
organism: Bos taurus

Alpha-2A adrenergic receptor
type: ProteinReference
xref: uniprot P08913 173
organism: Homo sapiens

Alpha adrenergic receptor signaling pathway
type: Pathway
pathway component: TRANSPORT_LEFT__Adrenaline-RIGHT__Adrenaline-_r56
pathway component: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r63
pathway component: STATE_TRANSITION_LEFT__NE-_Adrenaline-_Complex__Alpha1A_1B__1C_G_Protein__GDP_-RIGHT__Complex__Alpha1A_1B__1C_G_Protein__GDP_Adrenaline_or_NE_-_r66
pathway component: TRIGGER
pathway component: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_r67
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__DAG-_IP3-_r8
pathway component: STATE_TRANSITION_LEFT__NE-_Adrenaline-_Complex__Alpha1A_1B__1C_G_Protein__GDP_-RIGHT__Complex__Alpha1A_1B__1C_Adrenaline_or_NE__G_Protein_GDP_-_r64
pathway component: DISSOCIATION_LEFT__Complex__Alpha1A_1B__1C_Adrenaline_or_NE__G_Protein_GDP_-_GTP-RIGHT__Complex__GTP_G_Protein_-_Complex__Alpha1A_1B__1C_Adrenaline_or_NE_-_GDP-_r65
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r52
pathway component: TRANSPORT_LEFT__NE-RIGHT__NE-_r57
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r22
xref: PANTHER Pathway P00002 1
comment: MODEL_NOTES=Panther Pathway: P00002 The adrenergic receptors play a key role in the modulation of sympathetic nervous system activity as well as a site of action for many therapeutic agents. The alpha1-adrenergic receptor subtypes (alpha1A-, alpha1B-, alpha1D) are the prime mediators of smooth muscle contraction and hypertrophic growth. These receptors, when activated, increase heart rate and have been linked to heart disease. Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11454900 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1461261 Website=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6323228 PMID: 11454900 PMID: 1461261 PMID: 6323228

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 204
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

IP3R
type: ProteinReference
xref: P00076
standard name: inositol 1,4,5-triphosphate receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Alpha adrenergic receptor signaling pathway.PROTEIN.ION_CHANNEL.IP_sub_3_endsub_R
comment: ENTITY_REFERENCE_NOTES=Long Name: inositol 1,4,5-triphosphate receptor Synonym: ITPR Accession: P00076
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: Uncharacterized protein
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1 isoform 3

Alpha1A 1B 1C s6 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Alpha1A/1B/1C
stoichiometric coefficient: 1.0

uniprot Q6PC54 119
type: UnificationXref
id: Q6PC54
db: uniprot

uniprot H2R1H0 80
type: UnificationXref
id: H2R1H0
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa5 192
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR10218:SF328
type: RelationshipXref
id: PTHR10218:SF328
db: PANTHER Family
relationship type: By Homology

uniprot P08913 173
type: UnificationXref
id: P08913
db: uniprot

uniprot O44419 86
type: UnificationXref
id: O44419
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60879 96
organism: Mus musculus

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60878 95
organism: Gallus gallus

Adrenaline or NE s10 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adrenaline or NE
stoichiometric coefficient: 1.0

IP3R
type: Protein
entity reference: IP3R
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot F7EKN9 76
type: UnificationXref
id: F7EKN9
db: uniprot

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 110
organism: Emericella nidulans

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q5R1X1 112
xref: PTHR19305:SF5
organism: Pan troglodytes

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60877 94
xref: PTHR19305:SF5
organism: Macaca mulatta

uniprot F6VQP7 133
type: UnificationXref
id: F6VQP7
db: uniprot

uniprot P35348 181
type: UnificationXref
id: P35348
db: uniprot

uniprot A0A1D5QG31 159
type: UnificationXref
id: A0A1D5QG31
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 9

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60880 97
xref: PTHR19305:SF5
organism: Homo sapiens

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 225
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 226
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 108

uniprot H9ZA60 35
type: UnificationXref
id: H9ZA60
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot Q2KJD2 109
xref: PTHR45701:SF6
organism: Bos taurus

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa17 212
cellular location: Nerve Fiber c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q17QQ3 106
type: UnificationXref
id: Q17QQ3
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

uniprot E2QRU4 68
type: UnificationXref
id: E2QRU4
db: uniprot

SNARE
type: Protein
entity reference: SNARE
cellular location: dense core granule
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r22 225
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F1PL90 19
organism: Canis lupus familiaris

uniprot F6VVA6 26
type: UnificationXref
id: F6VVA6
db: uniprot

Adrenoceptor alpha 2B
type: ProteinReference
xref: uniprot F1Q1Q4 170
xref: PTHR24248:SF130
organism: Canis lupus familiaris

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63044 102
xref: PTHR45701:SF5
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r22 226
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot Q91UZ1 53
type: UnificationXref
id: Q91UZ1
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63045 103
xref: PTHR45701:SF5
organism: Rattus norvegicus

uniprot Q14643 137
type: UnificationXref
id: Q14643
db: uniprot

uniprot F1PWH1 70
type: UnificationXref
id: F1PWH1
db: uniprot

uniprot P35368 182
type: UnificationXref
id: P35368
db: uniprot

Synaptobrevin-1
type: ProteinReference
xref: uniprot O02495 84
xref: PTHR45701:SF3
organism: Caenorhabditis elegans

Adrenaline or NE s17 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adrenaline or NE
stoichiometric coefficient: 1.0

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa16 210
cellular location: Nerve Fiber c5
comment: SPECIES_TYPE=PROTEIN

uniprot P20444 151
type: UnificationXref
id: P20444
db: uniprot

uniprot H2Q995 78
type: UnificationXref
id: H2Q995
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF104
xref: uniprot F7EKN9 76
organism: Monodelphis domestica

uniprot A0A1D5Q4D0 4
type: UnificationXref
id: A0A1D5Q4D0
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__DAG-_IP3-_r8
controller: PLC

uniprot J9JHK9 36
type: UnificationXref
id: J9JHK9
db: uniprot

uniprot P60878 95
type: UnificationXref
id: P60878
db: uniprot

STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_r67
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 228
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 227
left: PLC
interaction type: STATE_TRANSITION
right: PLC

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q9QW07 58
organism: Rattus norvegicus

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

uniprot F1MDC9 139
type: UnificationXref
id: F1MDC9
db: uniprot

Alpha1A/1B/1C
type: ProteinReference
xref: P00078
standard name: Alpha adrenergic receptor 1A/1B/1C
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Alpha adrenergic receptor signaling pathway.PROTEIN.RECEPTOR.Alpha_sub_1A/1B/1C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Adrenoceptor alpha 1B
member entity reference: Uncharacterized protein
member entity reference: Alpha-1A adrenergic receptor
member entity reference: Adrenoceptor alpha 1A
member entity reference: Alpha-1B adrenergic receptor
member entity reference: Alpha-2C adrenergic receptor
member entity reference: Alpha-2B adrenergic receptor
member entity reference: Adrenoceptor alpha 2B
member entity reference: Alpha-2A adrenergic receptor
member entity reference: Alpha-1D adrenergic receptor

Alpha-1A adrenergic receptor
type: ProteinReference
xref: PTHR24248:SF16
xref: uniprot P43140 183
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r67 228
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 227
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

Alpha1A/1B/1C
type: Protein
entity reference: Alpha1A/1B/1C
feature: ACTIVE 61
feature: Alpha1A 1B 1C s16 sa13 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa13 200
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=PROTEIN

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63027 101
xref: PTHR45701:SF5
organism: Homo sapiens

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63026 100
xref: PTHR45701:SF5
organism: Bos taurus

uniprot Q9XWB7 59
type: UnificationXref
id: Q9XWB7
db: uniprot

GTP
type: SmallMolecule
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

uniprot O02495 84
type: UnificationXref
id: O02495
db: uniprot

PARTICIPANT STOICHIOMETRY r66 229
type: Stoichiometry
physical entity: NE
stoichiometric coefficient: 1.0

Alpha-1D adrenergic receptor
type: ProteinReference
xref: uniprot P23944 179
xref: PTHR24248:SF14
organism: Rattus norvegicus

STX6 isoform 2
type: ProteinReference
xref: PTHR19957:SF104
xref: uniprot H2R1H0 80
organism: Pan troglodytes

ncbitaxon 9544 5
type: UnificationXref
id: 9544
db: ncbitaxon

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 98
organism: Mus musculus

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot P63025 99
xref: PTHR45701:SF6
organism: Rattus norvegicus

Protein kinase C
type: ProteinReference
xref: uniprot F6RA79 140
xref: PTHR24356:SF193
organism: Monodelphis domestica

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 3

SNARE
type: ProteinReference
xref: P00074
standard name: N-ethylmaleimide-sensitive factor attachment protein receptor
comment: ENTITY_REFERENCE_ID_DESC=Alpha adrenergic receptor signaling pathway.PROTEIN.GENERIC.SNARE
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: N-ethylmaleimide-sensitive factor attachment protein receptor Synonym: SNARE Accession: P00074
member entity reference: Synaptosomal-associated protein
member entity reference: Syntaxin-6
member entity reference: Synaptosomal-associated protein 25
member entity reference: Uncharacterized protein
member entity reference: VAMP3 isoform 1
member entity reference: STX10 isoform 6
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Synaptosomal-associated protein 25-B
member entity reference: Neuronal synaptobrevin, isoform J
member entity reference: Vesicle-associated membrane protein 2
member entity reference: STX6 isoform 2
member entity reference: Synaptosomal-associated protein 25-A
member entity reference: Syntaxin-10
member entity reference: Syntaxin 6
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: Qc-SNARE protein, Tlg1/Syntaxin 6-family
member entity reference: STX6 protein
member entity reference: Synaptosomal-associated protein 23
member entity reference: Synaptobrevin
member entity reference: Syntaxin-61
member entity reference: Synaptobrevin homolog 1
member entity reference: Synaptobrevin-1
member entity reference: Vesicle associated membrane protein 1
member entity reference: Syntaxin 10
member entity reference: VAMP2 isoform 3

PARTICIPANT STOICHIOMETRY r66 231
type: Stoichiometry
physical entity: Complex (Alpha1A/1B/ 1C/G-Protein/ GDP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 232
type: Stoichiometry
physical entity: Complex (Alpha1A/1B/ 1C/G-Protein/ GDP/Adrenaline or NE)
stoichiometric coefficient: 1.0

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

uniprot Q02156 155
type: UnificationXref
id: Q02156
db: uniprot

PARTICIPANT STOICHIOMETRY r66 230
type: Stoichiometry
physical entity: Adrenaline
stoichiometric coefficient: 1.0

uniprot A0A2I3T596 168
type: UnificationXref
id: A0A2I3T596
db: uniprot

VAMP2 isoform 3
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot H2RCB8 81
organism: Pan troglodytes

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q02156 155
xref: PTHR24356:SF159
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot A0A2I3SSC7 129
xref: PTHR13715:SF52
organism: Pan troglodytes

smooth cardiac muscle, or neuron c2
type: CellularLocationVocabulary
comment: smooth/cardiac muscle, or neuron

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

Alpha-2B adrenergic receptor
type: ProteinReference
xref: uniprot P30545 180
xref: PTHR24248:SF130
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VQP7 133
xref: PTHR13715:SF52
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r52
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 224
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 223
left: PKC
interaction type: STATE_TRANSITION
right: PKC

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 122
organism: Schizosaccharomyces pombe

uniprot O89040 38
type: UnificationXref
id: O89040
db: uniprot

uniprot Q9QW07 58
type: UnificationXref
id: Q9QW07
db: uniprot

PTHR19957:SF106
type: RelationshipXref
id: PTHR19957:SF106
db: PANTHER Family
relationship type: By Homology

Qc-SNARE protein, Tlg1/Syntaxin 6-family
type: ProteinReference
xref: uniprot Q8S4W5 120
organism: Chlamydomonas reinhardtii

PTHR24248:SF130
type: RelationshipXref
id: PTHR24248:SF130
db: PANTHER Family
relationship type: By Homology

PTHR19957:SF104
type: RelationshipXref
id: PTHR19957:SF104
db: PANTHER Family
relationship type: By Homology

Complex (Alpha1A/1B/ 1C/G-Protein/ GDP/Adrenaline or NE)
type: Complex
component stoichiometry: G Protein s22 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s23 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Adrenaline or NE s24 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: Alpha1A 1B 1C s21 sa15 STOICHIOMETRY ID COMPLEX
component: G-Protein
component: GDP
component: Alpha1A/1B/1C
component: Adrenaline or NE
feature: COMPLEX BINDING FEATURE s116 a118 209
feature: COMPLEX BINDING FEATURE s116 a118 213
feature: COMPLEX BINDING FEATURE s116 a118 211
feature: COMPLEX BINDING FEATURE s116 a118 207
cellular location: Nerve Fiber c5

uniprot P97714 184
type: UnificationXref
id: P97714
db: uniprot

Syntaxin 6
type: ProteinReference
xref: PTHR19957:SF104
xref: uniprot F6XL80 71
organism: Ornithorhynchus anatinus

MODULATION
type: RelationshipTypeVocabulary

PTHR24248:SF16
type: RelationshipXref
id: PTHR24248:SF16
db: PANTHER Family
relationship type: By Homology

Bos taurus
type: BioSource
xref: ncbitaxon 9913 42

PTHR24248:SF17
type: RelationshipXref
id: PTHR24248:SF17
db: PANTHER Family
relationship type: By Homology

PTHR24248:SF14
type: RelationshipXref
id: PTHR24248:SF14
db: PANTHER Family
relationship type: By Homology

Alpha1A 1B 1C s21 sa15 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.4633432079864352
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Alpha1A/1B/1C
type: Protein
entity reference: Alpha1A/1B/1C
feature: Alpha1A 1B 1C s9 sa9 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa9 216
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=PROTEIN

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 5

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q9JID2 166
organism: Rattus norvegicus

uniprot P18489 89
type: UnificationXref
id: P18489
db: uniprot

uniprot P63319 154
type: UnificationXref
id: P63319
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 27

ncbitaxon 6239 30
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot P17252 150
type: UnificationXref
id: P17252
db: uniprot

PTHR10336:SF106
type: RelationshipXref
id: PTHR10336:SF106
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QKF0 167
type: UnificationXref
id: A0A1D5QKF0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot P10894 41
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot O89040 38
xref: PTHR10336:SF10
organism: Rattus norvegicus

uniprot H2QJY5 32
type: UnificationXref
id: H2QJY5
db: uniprot

Alpha-1A adrenergic receptor
type: ProteinReference
xref: uniprot P18130 176
xref: PTHR24248:SF16
organism: Bos taurus

P00077
type: UnificationXref
id: P00077
db: PANTHER Pathway Component

P00078
type: UnificationXref
id: P00078
db: PANTHER Pathway Component

P00075
type: UnificationXref
id: P00075
db: PANTHER Pathway Component

P00076
type: UnificationXref
id: P00076
db: PANTHER Pathway Component

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 206
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=PROTEIN

P00073
type: UnificationXref
id: P00073
db: PANTHER Pathway Component

P00074
type: UnificationXref
id: P00074
db: PANTHER Pathway Component

ncbitaxon 9258 27
type: UnificationXref
id: 9258
db: ncbitaxon

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot P97717 185
type: UnificationXref
id: P97717
db: uniprot

PLC
type: Protein
entity reference: PLC
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QYR9 63
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

uniprot F1Q1Q4 170
type: UnificationXref
id: F1Q1Q4
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot K7CBH8 145
xref: PTHR24356:SF159
organism: Pan troglodytes

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 18

uniprot P10894 41
type: UnificationXref
id: P10894
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q08BT6 157
xref: PTHR24356:SF159
organism: Xenopus tropicalis

uniprot Q92356 122
type: UnificationXref
id: Q92356
db: uniprot

VAMP3 isoform 1
type: ProteinReference
xref: uniprot G2HIJ9 77
xref: PTHR45701:SF6
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r52
controller: DAG

Alpha1A 1B 1C s16 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Alpha1A/1B/1C
stoichiometric coefficient: 1.0

uniprot P18130 176
type: UnificationXref
id: P18130
db: uniprot

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

GO GO:0005783 3
type: UnificationXref
id: GO:0005783
db: GO

ncbitaxon 10116 39
type: UnificationXref
id: 10116
db: ncbitaxon

GDP
type: SmallMolecule
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 12

Syntaxin-61
type: ProteinReference
xref: uniprot Q946Y7 124
organism: Arabidopsis thaliana

uniprot Q15147 50
type: UnificationXref
id: Q15147
db: uniprot

uniprot Q5TZ66 113
type: UnificationXref
id: Q5TZ66
db: uniprot

uniprot P10687 40
type: UnificationXref
id: P10687
db: uniprot

uniprot F7BIC2 141
type: UnificationXref
id: F7BIC2
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q5PU49 158
xref: PTHR24356:SF365
organism: Canis lupus familiaris

Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
type: ProteinReference
xref: uniprot H9FU38 134
xref: PTHR13715:SF52
organism: Macaca mulatta

Syntaxin-10
type: ProteinReference
xref: uniprot O60499 88
xref: PTHR19957:SF106
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F7ECA6 161
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P21278 162
xref: PTHR10218:SF328
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot A3KGF7 13
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot A0A3Q2U0G2 11
organism: Gallus gallus

uniprot A0A3Q2UD13 130
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot Q9VH76 128
organism: Drosophila melanogaster

Alpha1A/1B/1C
type: Protein
entity reference: Alpha1A/1B/1C
feature: Alpha1A 1B 1C s3 sa3 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 188
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YMH2 73
xref: PTHR45701:SF6
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F1PLB3 20
xref: PTHR10336:SF106
organism: Canis lupus familiaris

uniprot A8XRA5 15
type: UnificationXref
id: A8XRA5
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

Alpha-2C adrenergic receptor
type: ProteinReference
xref: uniprot P18825 177
organism: Homo sapiens

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 121

GDP s8 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

G Protein s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot Q01970 49
type: UnificationXref
id: Q01970
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A943 75
xref: PTHR45701:SF5
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot G7NAM7 171
xref: PTHR24248:SF130
organism: Macaca mulatta

uniprot H2QRX4 172
type: UnificationXref
id: H2QRX4
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa12 222
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6VHF7 132
type: UnificationXref
id: F6VHF7
db: uniprot

uniprot Q05655 156
type: UnificationXref
id: Q05655
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F6VVA6 26
organism: Ornithorhynchus anatinus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot H2QDQ1 143
organism: Pan troglodytes

PTHR10336:SF11
type: RelationshipXref
id: PTHR10336:SF11
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF12
type: RelationshipXref
id: PTHR10336:SF12
db: PANTHER Family
relationship type: By Homology

uniprot F7H3B3 142
type: UnificationXref
id: F7H3B3
db: uniprot

G Protein s11 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

PTHR10336:SF10
type: RelationshipXref
id: PTHR10336:SF10
db: PANTHER Family
relationship type: By Homology

uniprot Q2KJD2 109
type: UnificationXref
id: Q2KJD2
db: uniprot

uniprot Q9VH76 128
type: UnificationXref
id: Q9VH76
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QKF0 167
xref: PTHR24248:SF16
organism: Macaca mulatta

NE
type: SmallMolecule
cellular location: dense core granule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 16

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 30

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot P13217 43
organism: Drosophila melanogaster

Phosphoinositide phospholipase C
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot H2RB55 33
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QLN2 62
xref: PTHR19957:SF104
organism: Macaca mulatta

TRIGGER
type: Control
xref: TRIGGER
controlled: Muscle Contraction
controller: Ca2+

dense core granule
type: CellularLocationVocabulary
xref: GO GO:0031045 2

uniprot H9EU39 144
type: UnificationXref
id: H9EU39
db: uniprot

Complex (Alpha1A/1B/ 1C/Adrenaline or NE)
type: Complex
component stoichiometry: Adrenaline or NE s17 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: Alpha1A 1B 1C s16 sa13 STOICHIOMETRY ID COMPLEX
component: Adrenaline or NE
component: Alpha1A/1B/1C
feature: COMPLEX BINDING FEATURE s109 a109 201
feature: COMPLEX BINDING FEATURE s109 a109 199
cellular location: smooth cardiac muscle, or neuron c2

ncbitaxon 6238 16
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot F6THW2 160
type: UnificationXref
id: F6THW2
db: uniprot

G Protein s7 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot P51432 46
xref: PTHR10336:SF11
organism: Mus musculus

uniprot P63318 153
type: UnificationXref
id: P63318
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF106
xref: uniprot E1BQ02 67
organism: Bos taurus

uniprot P63026 100
type: UnificationXref
id: P63026
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UD13 130
xref: PTHR13715:SF52
organism: Gallus gallus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F6ZKL2 28
organism: Macaca mulatta

uniprot A0A1D5R985 138
type: UnificationXref
id: A0A1D5R985
db: uniprot

TRANSPORT_LEFT__NE-RIGHT__NE-_r57
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 248
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 247
left: NE
interaction type: TRANSPORT
right: NE

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot A0A1D5QG31 159
xref: PTHR10218:SF328
organism: Macaca mulatta

uniprot P63027 101
type: UnificationXref
id: P63027
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A0A1D5R985 138
xref: PTHR24356:SF193
organism: Macaca mulatta

uniprot Q0V7N0 104
type: UnificationXref
id: Q0V7N0
db: uniprot

PARTICIPANT STOICHIOMETRY r63 242
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

Alpha1A 1B 1C s9 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Alpha1A/1B/1C
stoichiometric coefficient: 1.0

uniprot P09215 148
type: UnificationXref
id: P09215
db: uniprot

PARTICIPANT STOICHIOMETRY r63 243
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot Q99P84 55
organism: Rattus norvegicus

uniprot H2RB55 33
type: UnificationXref
id: H2RB55
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P28867 152
organism: Mus musculus

Alpha1A 1B 1C s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Alpha1A/1B/1C
stoichiometric coefficient: 1.0

PANTHER Pathway P00002 1
type: UnificationXref
id: P00002
db: PANTHER Pathway

Synaptobrevin
type: ProteinReference
xref: PTHR45701:SF10
xref: uniprot P18489 89
organism: Drosophila melanogaster

uniprot P60880 97
type: UnificationXref
id: P60880
db: uniprot

uniprot Q08BT6 157
type: UnificationXref
id: Q08BT6
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

GO GO:0031045 2
type: UnificationXref
id: GO:0031045
db: GO

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 22

uniprot Q8S4W5 120
type: UnificationXref
id: Q8S4W5
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot Q9P212 57
organism: Homo sapiens

uniprot P25455 45
type: UnificationXref
id: P25455
db: uniprot

TRANSPORT_LEFT__Adrenaline-RIGHT__Adrenaline-_r56
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 249
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 250
left: Adrenaline
interaction type: TRANSPORT
right: Adrenaline

uniprot P23944 179
type: UnificationXref
id: P23944
db: uniprot

Syntaxin 10
type: ProteinReference
xref: uniprot E2QRU4 68
xref: PTHR19957:SF106
organism: Canis lupus familiaris

ACTIVE 61
type: EntityFeature
comment: Active state

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F6SD46 23
organism: Monodelphis domestica

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5TZ66 113
organism: Danio rerio

uniprot P11881 135
type: UnificationXref
id: P11881
db: uniprot

uniprot A5PEW5 65
type: UnificationXref
id: A5PEW5
db: uniprot

Alpha1A 1B 1C s21 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Alpha1A/1B/1C
stoichiometric coefficient: 1.0

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A5PEW5 65
organism: Caenorhabditis elegans

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A8X8S6 66
organism: Caenorhabditis briggsae

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P11881 135
xref: PTHR13715:SF52
organism: Mus musculus

uniprot P97718 186
type: UnificationXref
id: P97718
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F6THW2 160
organism: Xenopus tropicalis

ncbitaxon 7955 114
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot P63045 103
type: UnificationXref
id: P63045
db: uniprot

Complex (Alpha1A/1B/ 1C/G-Protein/ GDP)
type: Complex
component stoichiometry: GDP s8 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s7 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Alpha1A 1B 1C s6 sa6 STOICHIOMETRY ID COMPLEX
component: GDP
component: Alpha1A/1B/1C
component: G-Protein
feature: COMPLEX BINDING FEATURE s95 a94 197
feature: COMPLEX BINDING FEATURE s95 a94 193
feature: COMPLEX BINDING FEATURE s95 a94 195
cellular location: Nerve Fiber c5

ncbitaxon 7227 44
type: UnificationXref
id: 7227
db: ncbitaxon

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q63666 118
organism: Rattus norvegicus

uniprot A8X8S6 66
type: UnificationXref
id: A8X8S6
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

uniprot F7ECA6 161
type: UnificationXref
id: F7ECA6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q91UZ1 53
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot Q8K4S1 52
organism: Mus musculus

uniprot F6XYX9 72
type: UnificationXref
id: F6XYX9
db: uniprot

uniprot Q9Z1B3 60
type: UnificationXref
id: Q9Z1B3
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot P16054 149
xref: PTHR24356:SF159
organism: Mus musculus

PTHR10336:SF149
type: RelationshipXref
id: PTHR10336:SF149
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot Q9Z1B3 60
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
type: ProteinReference
xref: PTHR10336:SF6
xref: uniprot G5EFI8 31
organism: Caenorhabditis elegans

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot Q00722 47
organism: Homo sapiens

Alpha-2B adrenergic receptor
type: ProteinReference
xref: PTHR24248:SF130
xref: uniprot P19328 178
organism: Rattus norvegicus

uniprot Q63635 117
type: UnificationXref
id: Q63635
db: uniprot

uniprot Q5ZL19 115
type: UnificationXref
id: Q5ZL19
db: uniprot

PARTICIPANT STOICHIOMETRY r8 246
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

Alpha-2B adrenergic receptor
type: ProteinReference
xref: uniprot P18089 174
xref: PTHR24248:SF130
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r8 244
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 245
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

uniprot A0A1D5QLN2 62
type: UnificationXref
id: A0A1D5QLN2
db: uniprot

uniprot G7NAM7 171
type: UnificationXref
id: G7NAM7
db: uniprot

By Homology
type: RelationshipTypeVocabulary

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 24

ncbitaxon 9615 18
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot M9PE71 82
type: UnificationXref
id: M9PE71
db: uniprot

ncbitaxon 7165 22
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot F1MGA6 169
type: UnificationXref
id: F1MGA6
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot F7BIC2 141
xref: PTHR24356:SF159
organism: Macaca mulatta

uniprot Q8K4S1 52
type: UnificationXref
id: Q8K4S1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_r67
controller: Complex (GTP/G-Protein)

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O00161 83
organism: Homo sapiens

STX10 isoform 6
type: ProteinReference
xref: uniprot H2QFI5 79
xref: PTHR19957:SF106
organism: Pan troglodytes

uniprot P19328 178
type: UnificationXref
id: P19328
db: uniprot

uniprot E1BQ02 67
type: UnificationXref
id: E1BQ02
db: uniprot

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05129 147
organism: Homo sapiens

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 123

uniprot A0A2J8QDF6 10
type: UnificationXref
id: A0A2J8QDF6
db: uniprot

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: uniprot P05128 146
xref: PTHR24356:SF162
organism: Bos taurus

uniprot H2QFI5 79
type: UnificationXref
id: H2QFI5
db: uniprot

uniprot K7CBH8 145
type: UnificationXref
id: K7CBH8
db: uniprot

uniprot P60879 96
type: UnificationXref
id: P60879
db: uniprot

uniprot Q5RKP9 165
type: UnificationXref
id: Q5RKP9
db: uniprot

uniprot P63044 102
type: UnificationXref
id: P63044
db: uniprot

uniprot P18089 174
type: UnificationXref
id: P18089
db: uniprot

uniprot P36975 93
type: UnificationXref
id: P36975
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot G5EBH0 29
organism: Caenorhabditis elegans

Vesicle associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot F1PRG8 69
organism: Canis lupus familiaris

G-Protein
type: ProteinReference
xref: P00077
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alpha adrenergic receptor signaling pathway.PROTEIN.GENERIC.G-Protein
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)

uniprot A3KGF7 13
type: UnificationXref
id: A3KGF7
db: uniprot

uniprot Q9N0Y0 127
type: UnificationXref
id: Q9N0Y0
db: uniprot

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P20444 151
xref: PTHR24356:SF193
organism: Mus musculus

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

ncbitaxon 8364 108
type: UnificationXref
id: 8364
db: ncbitaxon

Complex (Alpha1A/1B/ 1C/Adrenaline or NE/ G-Protein/GDP)
type: Complex
component stoichiometry: Adrenaline or NE s10 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s11 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s12 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: Alpha1A 1B 1C s9 sa9 STOICHIOMETRY ID COMPLEX
component: GDP
component: G-Protein
component: Alpha1A/1B/1C
component: Adrenaline or NE
feature: COMPLEX BINDING FEATURE s106 a103 219
feature: COMPLEX BINDING FEATURE s106 a103 215
feature: COMPLEX BINDING FEATURE s106 a103 221
feature: COMPLEX BINDING FEATURE s106 a103 217
cellular location: smooth cardiac muscle, or neuron c2

uniprot F1PLB3 20
type: UnificationXref
id: F1PLB3
db: uniprot

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

Syntaxin-6
type: ProteinReference
xref: PTHR19957:SF104
xref: uniprot Q9JKK1 126
organism: Mus musculus

Phosphoinositide phospholipase C (Fragment)
type: ProteinReference
xref: PTHR10336:SF149
xref: uniprot Q7PW25 51
organism: Anopheles gambiae

Alpha1A 1B 1C s9 sa9 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.4633432079864352
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Adrenaline
type: SmallMolecule
cellular location: dense core granule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: uniprot P38409 164
xref: PTHR10218:SF328
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 48

uniprot Q5R1X1 112
type: UnificationXref
id: Q5R1X1
db: uniprot

uniprot Q946Y7 124
type: UnificationXref
id: Q946Y7
db: uniprot

DISSOCIATION_LEFT__Complex__Alpha1A_1B__1C_Adrenaline_or_NE__G_Protein_GDP_-_GTP-RIGHT__Complex__GTP_G_Protein_-_Complex__Alpha1A_1B__1C_Adrenaline_or_NE_-_GDP-_r65
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 234
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 236
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 235
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 237
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 233
left: GTP
left: Complex (Alpha1A/1B/ 1C/Adrenaline or NE/ G-Protein/GDP)
interaction type: DISSOCIATION
right: Complex (Alpha1A/1B/ 1C/Adrenaline or NE)
right: Complex (GTP/G-Protein)
right: GDP

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A2I3T8F7 8
xref: PTHR10336:SF11
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F5HMB9 21
organism: Anopheles gambiae

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 125

uniprot A2VE18 64
type: UnificationXref
id: A2VE18
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q28HP6 107
organism: Xenopus tropicalis

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F1MX21 131
xref: PTHR13715:SF52
organism: Bos taurus

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa11 220
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=PROTEIN

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q99JE6 54
xref: PTHR10336:SF11
organism: Rattus norvegicus

uniprot H9FU38 134
type: UnificationXref
id: H9FU38
db: uniprot

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

Adrenaline or NE
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa18 214
cellular location: Nerve Fiber c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 87

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q15836 105
type: UnificationXref
id: Q15836
db: uniprot

uniprot Q63666 118
type: UnificationXref
id: Q63666
db: uniprot

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P29992 163
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot P29994 136
xref: PTHR13715:SF52
organism: Rattus norvegicus

uniprot F1MX21 131
type: UnificationXref
id: F1MX21
db: uniprot

Adrenoceptor alpha 1B
type: ProteinReference
xref: PTHR24248:SF17
xref: uniprot H2QRX4 172
organism: Pan troglodytes

Nerve Fiber c5
type: CellularLocationVocabulary
comment: Nerve Fiber

Danio rerio
type: BioSource
xref: ncbitaxon 7955 114

uniprot Q28HP6 107
type: UnificationXref
id: Q28HP6
db: uniprot

uniprot P43140 183
type: UnificationXref
id: P43140
db: uniprot

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 91
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r57 247
type: Stoichiometry
physical entity: NE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 248
type: Stoichiometry
physical entity: NE
stoichiometric coefficient: 1.0

uniprot F6XL80 71
type: UnificationXref
id: F6XL80
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q17QQ3 106
xref: PTHR19305:SF5
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r52 223
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r52 224
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot F6YXV7 74
type: UnificationXref
id: F6YXV7
db: uniprot

uniprot H2RCB8 81
type: UnificationXref
id: H2RCB8
db: uniprot

Complex (Alpha1A/1B/ 1C/G-Protein/ GDP)
type: Complex
component stoichiometry: Alpha1A 1B 1C s3 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s5 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s4 sa4 STOICHIOMETRY ID COMPLEX
component: G-Protein
component: Alpha1A/1B/1C
component: GDP
feature: COMPLEX BINDING FEATURE s68 a77 187
feature: COMPLEX BINDING FEATURE s68 a77 189
feature: COMPLEX BINDING FEATURE s68 a77 191
cellular location: smooth cardiac muscle, or neuron c2

Alpha-1A adrenergic receptor
type: ProteinReference
xref: uniprot P35348 181
xref: PTHR24248:SF16
organism: Homo sapiens

DAG
type: SmallMolecule
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q9N0Y0 127
xref: PTHR45701:SF5
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: PTHR24351:SF182
xref: uniprot F1MDC9 139
organism: Bos taurus

uniprot O00161 83
type: UnificationXref
id: O00161
db: uniprot

uniprot E2RT75 17
type: UnificationXref
id: E2RT75
db: uniprot

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P36975 93
xref: PTHR19305:SF14
organism: Drosophila melanogaster

Alpha1A 1B 1C s6 sa6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.4633432079864352
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY r56 250
type: Stoichiometry
physical entity: Adrenaline
stoichiometric coefficient: 1.0

G Protein s4 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

ncbitaxon 284812 123
type: UnificationXref
id: 284812
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot A0A2J8QDF6 10
organism: Pan troglodytes

PLC
type: ProteinReference
xref: P00073
standard name: Phospholipase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phospholipase C Synonym: PLC Accession: P00073
comment: ENTITY_REFERENCE_ID_DESC=Alpha adrenergic receptor signaling pathway.PROTEIN.GENERIC.PLC
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
member entity reference: Phosphoinositide phospholipase C
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
member entity reference: Phosphoinositide phospholipase C (Fragment)
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8

Vesicle-associated membrane protein 3
type: ProteinReference
xref: uniprot Q15836 105
xref: PTHR45701:SF6
organism: Homo sapiens

STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 242
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 243
left: IP3R
interaction type: STATE_TRANSITION
right: IP3R

PLC
type: Protein
entity reference: PLC
feature: ACTIVE 61
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3T8F7 8
type: UnificationXref
id: A0A2I3T8F7
db: uniprot

Alpha1A/1B/1C
type: Protein
entity reference: Alpha1A/1B/1C
feature: Alpha1A 1B 1C s6 sa6 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa6 194
cellular location: Nerve Fiber c5
comment: SPECIES_TYPE=PROTEIN

uniprot F7A943 75
type: UnificationXref
id: F7A943
db: uniprot

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q6PC54 119
organism: Danio rerio

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 175

uniprot P16054 149
type: UnificationXref
id: P16054
db: uniprot

uniprot F1PRG8 69
type: UnificationXref
id: F1PRG8
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q15147 50
organism: Homo sapiens

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot O44419 86
organism: Strongylocentrotus purpuratus

Syntaxin-10
type: ProteinReference
xref: uniprot F6YXV7 74
xref: PTHR19957:SF106
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot J9JHK9 36
xref: PTHR10336:SF11
organism: Canis lupus familiaris

uniprot F6ZKL2 28
type: UnificationXref
id: F6ZKL2
db: uniprot

uniprot P31109 91
type: UnificationXref
id: P31109
db: uniprot

GTP s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot G5EBH0 29
type: UnificationXref
id: G5EBH0
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot P09215 148
xref: PTHR24356:SF365
organism: Rattus norvegicus

uniprot Q99JE6 54
type: UnificationXref
id: Q99JE6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot P10687 40
organism: Rattus norvegicus

uniprot P23763 90
type: UnificationXref
id: P23763
db: uniprot

ncbitaxon 7668 87
type: UnificationXref
id: 7668
db: ncbitaxon

Alpha-1A adrenergic receptor
type: ProteinReference
xref: uniprot P97718 186
xref: PTHR24248:SF16
organism: Mus musculus

Adrenaline
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Alpha-1B adrenergic receptor
type: ProteinReference
xref: PTHR24248:SF17
xref: uniprot P97717 185
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot K7BA21 37
organism: Pan troglodytes

Alpha-1D adrenergic receptor
type: ProteinReference
xref: uniprot P97714 184
xref: PTHR24248:SF14
organism: Mus musculus

IP3R
type: Protein
entity reference: IP3R
feature: ACTIVE 61
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot G5EFI8 31
type: UnificationXref
id: G5EFI8
db: uniprot

uniprot P05128 146
type: UnificationXref
id: P05128
db: uniprot

Syntaxin 6
type: ProteinReference
xref: PTHR19957:SF104
xref: uniprot F1PWH1 70
organism: Canis lupus familiaris

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q62442 116
organism: Mus musculus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 39

uniprot G2HIJ9 77
type: UnificationXref
id: G2HIJ9
db: uniprot

PTHR10336:SF6
type: RelationshipXref
id: PTHR10336:SF6
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: uniprot F7H3B3 142
xref: PTHR24356:SF162
organism: Macaca mulatta

ncbitaxon 559292 92
type: UnificationXref
id: 559292
db: ncbitaxon

ncbitaxon 9913 42
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot H2QDQ1 143
type: UnificationXref
id: H2QDQ1
db: uniprot

STATE_TRANSITION_LEFT__NE-_Adrenaline-_Complex__Alpha1A_1B__1C_G_Protein__GDP_-RIGHT__Complex__Alpha1A_1B__1C_G_Protein__GDP_Adrenaline_or_NE_-_r66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 229
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 232
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 231
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 230
left: Complex (Alpha1A/1B/ 1C/G-Protein/ GDP)
left: NE
left: Adrenaline
interaction type: STATE_TRANSITION
right: Complex (Alpha1A/1B/ 1C/G-Protein/ GDP/Adrenaline or NE)

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q05655 156
xref: PTHR24356:SF365
organism: Homo sapiens

uniprot K7BA21 37
type: UnificationXref
id: K7BA21
db: uniprot

PARTICIPANT STOICHIOMETRY r56 249
type: Stoichiometry
physical entity: Adrenaline
stoichiometric coefficient: 1.0

uniprot Q5PU49 158
type: UnificationXref
id: Q5PU49
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot H9EU39 144
organism: Macaca mulatta

uniprot P29992 163
type: UnificationXref
id: P29992
db: uniprot

ncbitaxon 10090 14
type: UnificationXref
id: 10090
db: ncbitaxon

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P17252 150
xref: PTHR24356:SF193
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r22
control type: ACTIVATION
controller: IP3R

uniprot P05129 147
type: UnificationXref
id: P05129
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot P23763 90
organism: Homo sapiens

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa8 198
cellular location: Nerve Fiber c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

IP3
type: SmallMolecule
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Alpha1A 1B 1C s16 sa13 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.4633432079864352
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PKC
type: ProteinReference
xref: P00075
standard name: protein kinase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: protein kinase C Synonym: PKC Accession: P00075
comment: ENTITY_REFERENCE_ID_DESC=Alpha adrenergic receptor signaling pathway.PROTEIN.GENERIC.PKC
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C gamma type (Fragment)
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C

PARTICIPANT STOICHIOMETRY r64 241
type: Stoichiometry
physical entity: Complex (Alpha1A/1B/ 1C/Adrenaline or NE/ G-Protein/GDP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 240
type: Stoichiometry
physical entity: Complex (Alpha1A/1B/ 1C/G-Protein/ GDP)
stoichiometric coefficient: 1.0

uniprot P28867 152
type: UnificationXref
id: P28867
db: uniprot

uniprot F6RA79 140
type: UnificationXref
id: F6RA79
db: uniprot

uniprot P38409 164
type: UnificationXref
id: P38409
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot H9FVW1 34
organism: Macaca mulatta

Adrenaline or NE s24 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Adrenaline or NE
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

uniprot Q9NQ66 56
type: UnificationXref
id: Q9NQ66
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot Q0V7N0 104
organism: Bos taurus

uniprot P63024 98
type: UnificationXref
id: P63024
db: uniprot

Ca2+
type: SmallMolecule
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=ION

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A1D5Q4D0 4
xref: PTHR10336:SF11
organism: Macaca mulatta

STATE_TRANSITION_LEFT__NE-_Adrenaline-_Complex__Alpha1A_1B__1C_G_Protein__GDP_-RIGHT__Complex__Alpha1A_1B__1C_Adrenaline_or_NE__G_Protein_GDP_-_r64
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 239
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 241
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 238
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 240
left: Complex (Alpha1A/1B/ 1C/G-Protein/ GDP)
left: NE
left: Adrenaline
interaction type: STATE_TRANSITION
right: Complex (Alpha1A/1B/ 1C/Adrenaline or NE/ G-Protein/GDP)

uniprot F6SD46 23
type: UnificationXref
id: F6SD46
db: uniprot

G Protein s22 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q9XWB7 59
xref: PTHR10336:SF149
organism: Caenorhabditis elegans

uniprot P51432 46
type: UnificationXref
id: P51432
db: uniprot

uniprot Q62442 116
type: UnificationXref
id: Q62442
db: uniprot

ncbitaxon 9606 48
type: UnificationXref
id: 9606
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r65 234
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot F6YMH2 73
type: UnificationXref
id: F6YMH2
db: uniprot

PARTICIPANT STOICHIOMETRY r65 235
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r65 233
type: Stoichiometry
physical entity: Complex (Alpha1A/1B/ 1C/Adrenaline or NE/ G-Protein/GDP)
stoichiometric coefficient: 1.0

uniprot P30545 180
type: UnificationXref
id: P30545
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__NE-RIGHT__NE-_r57
control type: ACTIVATION
controller: SNARE

Alpha-1B adrenergic receptor
type: ProteinReference
xref: PTHR24248:SF17
xref: uniprot P35368 182
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r65 236
type: Stoichiometry
physical entity: Complex (Alpha1A/1B/ 1C/Adrenaline or NE)
stoichiometric coefficient: 1.0

STX6 protein
type: ProteinReference
xref: PTHR19957:SF104
xref: uniprot A2VE18 64
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r65 237
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Alpha1A 1B 1C s3 sa3 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=3.4633432079864352
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q99P84 55
type: UnificationXref
id: Q99P84
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
type: ProteinReference
xref: PTHR10336:SF149
xref: uniprot P25455 45
organism: Drosophila melanogaster

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot H2Q995 78
xref: PTHR19305:SF4
organism: Pan troglodytes

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

GDP s23 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot H2QJY5 32
organism: Pan troglodytes

ncbitaxon 9031 12
type: UnificationXref
id: 9031
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot E2RT75 17
organism: Canis lupus familiaris

uniprot P29994 136
type: UnificationXref
id: P29994
db: uniprot

uniprot Q5ASG1 110
type: UnificationXref
id: Q5ASG1
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r63
controller: IP3

Alpha1A/1B/1C
type: Protein
entity reference: Alpha1A/1B/1C
feature: Alpha1A 1B 1C s21 sa15 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa15 208
cellular location: Nerve Fiber c5
comment: SPECIES_TYPE=PROTEIN

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 111

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot Q9NQ66 56
organism: Homo sapiens

uniprot P21278 162
type: UnificationXref
id: P21278
db: uniprot

uniprot A0A3Q2U0G2 11
type: UnificationXref
id: A0A3Q2U0G2
db: uniprot

uniprot Q00722 47
type: UnificationXref
id: Q00722
db: uniprot

PARTICIPANT STOICHIOMETRY r64 239
type: Stoichiometry
physical entity: Adrenaline
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 238
type: Stoichiometry
physical entity: NE
stoichiometric coefficient: 1.0

Adrenaline or NE
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa14 202
cellular location: smooth cardiac muscle, or neuron c2
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Syntaxin-6
type: ProteinReference
xref: PTHR19957:SF104
xref: uniprot Q63635 117
organism: Rattus norvegicus