APP
type: Protein
entity reference: APP
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa16 642
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Kinesin light chain 1
type: ProteinReference
xref: uniprot P37285 465
xref: PTHR45783:SF7
organism: Rattus norvegicus

uniprot F6YAB9 271
type: UnificationXref
id: F6YAB9
db: uniprot

PTHR24356:SF303
type: RelationshipXref
id: PTHR24356:SF303
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot E2QVF3 250
organism: Canis lupus familiaris

uniprot Q16539 329
type: UnificationXref
id: Q16539
db: uniprot

ncbitaxon 9598 16
type: UnificationXref
id: 9598
db: ncbitaxon

BACE-1 pro-domain
type: ProteinReference
xref: P00094
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.BACE-1_br_pro-domain
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: BACE-1 pro-domainSynonym: Synonym not specifiedAccession: P00094
member entity reference: Uncharacterized protein
member entity reference: Beta-secretase 1
member entity reference: Beta-secretase 2
member entity reference: BACE2 isoform 3

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

uniprot Q5G235 172
type: UnificationXref
id: Q5G235
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot Q16659 330
organism: Homo sapiens

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF10
xref: uniprot Q5TZF1 80
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r43 702
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r43 703
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

Abeta
type: Protein
entity reference: Abeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa15 628
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1LM61 495
type: UnificationXref
id: A0A3Q1LM61
db: uniprot

PARTICIPANT STOICHIOMETRY r43 704
type: Stoichiometry
physical entity: Complex (APP/Fe65)
stoichiometric coefficient: 1.0

uniprot P49186 315
type: UnificationXref
id: P49186
db: uniprot

uniprot P26016 425
type: UnificationXref
id: P26016
db: uniprot

Presenilin N terminal fragment s38 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin N-terminal fragment
stoichiometric coefficient: 1.0

APP
type: ProteinReference
xref: P00085
standard name: Amyloid precursor protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.APP
comment: ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor proteinSynonym: Synonym not specifiedAccession: P00085
member entity reference: Amyloid-beta A4 protein
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta precursor protein

Uncharacterized protein
type: ProteinReference
xref: PTHR45783:SF6
xref: uniprot F7HGT8 461
organism: Macaca mulatta

Mus musculus
type: BioSource
xref: ncbitaxon 10090 22

uniprot H9G0E6 192
type: UnificationXref
id: H9G0E6
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P28482 309
organism: Homo sapiens

uniprot P20309 117
type: UnificationXref
id: P20309
db: uniprot

Amyloid beta precursor protein binding family A member 2
type: ProteinReference
xref: PTHR12345:SF12
xref: uniprot F1PP27 131
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 259
organism: Canis lupus familiaris

uniprot Q9C9U4 372
type: UnificationXref
id: Q9C9U4
db: uniprot

PTHR24356:SF322
type: RelationshipXref
id: PTHR24356:SF322
db: PANTHER Family
relationship type: By Homology

uniprot Q9DGE1 374
type: UnificationXref
id: Q9DGE1
db: uniprot

Voltage-dependent L-type calcium channel subunit alpha (Fragment)
type: ProteinReference
xref: uniprot A8X1H0 53
organism: Caenorhabditis briggsae

uniprot O08874 529
type: UnificationXref
id: O08874
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 305
organism: Homo sapiens

uniprot F6V332 267
type: UnificationXref
id: F6V332
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PAB2 445
xref: PTHR45783:SF7
organism: Gallus gallus

uniprot A0A2I3SHJ9 51
type: UnificationXref
id: A0A2I3SHJ9
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 393

PTHR24356:SF318
type: RelationshipXref
id: PTHR24356:SF318
db: PANTHER Family
relationship type: By Homology

Gamma-secretase subunit APH-1B
type: ProteinReference
xref: uniprot Q8C7N7 198
xref: PTHR12889:SF1
organism: Mus musculus

Proprotein convertase subtilisin/kexin type 2
type: ProteinReference
xref: uniprot F6U002 406
organism: Xenopus tropicalis

Gene transcription
type: Pathway

uniprot P28867 545
type: UnificationXref
id: P28867
db: uniprot

HETERODIMER ASSOCIATION LEFT Presenilin N terminal fragment- Aph 1- Nicastrin- Presenilin C terminal fragment- Pen 2-RIGHT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment - r77
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 685
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 687
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 686
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 689
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 690
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 688
left: Presenilin C-terminal fragment
left: Pen-2
left: Presenilin N-terminal fragment
left: Aph-1
left: Nicastrin
display name: HETERODIMER_ASSOCIATION_LEFT__Presenilin_N_terminal_fragment-_Aph_1-_Nicastrin-_Presenilin_C_terminal_fragment-_Pen_2-RIGHT__Complex__Nicastrin_Aph_1__Pen_2_Presenilin_N_terminal_fragment__Presenilin_C_terminal_fragment_-_r77
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

Presenilin
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot F7C949 151
organism: Xenopus tropicalis

PTHR24356:SF347
type: RelationshipXref
id: PTHR24356:SF347
db: PANTHER Family
relationship type: By Homology

Microtubule s32 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Microtubule
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Tip60-_Complex__AICD_Fe65_-RIGHT__Complex__AICD_Fe65__Tip60_-_r51
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 657
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 656
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 658
left: Tip60
left: Complex (AICD/Fe65)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (AICD/Fe65/ Tip60)

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r53
control type: ACTIVATION
controller: Muscarinic acetylcholine receptors

uniprot F7AGU8 150
type: UnificationXref
id: F7AGU8
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O42376 297
organism: Danio rerio

uniprot H2R439 417
type: UnificationXref
id: H2R439
db: uniprot

uniprot P49187 316
type: UnificationXref
id: P49187
db: uniprot

Disintegrin and metalloproteinase domain-containing protein 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot Q9Z1K9 210
organism: Rattus norvegicus

PTHR11905:SF136
type: RelationshipXref
id: PTHR11905:SF136
db: PANTHER Family
relationship type: By Homology

uniprot F7HGT8 461
type: UnificationXref
id: F7HGT8
db: uniprot

PTHR18945:SF832
type: RelationshipXref
id: PTHR18945:SF832
db: PANTHER Family
relationship type: By Homology

Presenilin N terminal fragment s16 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin N-terminal fragment
stoichiometric coefficient: 1.0

Protein kinase C-like 1B
type: ProteinReference
xref: uniprot P34885 547
xref: PTHR24356:SF240
organism: Caenorhabditis elegans

uniprot Q16549 436
type: UnificationXref
id: Q16549
db: uniprot

uniprot F1MCT1 402
type: UnificationXref
id: F1MCT1
db: uniprot

uniprot F7DJJ2 103
type: UnificationXref
id: F7DJJ2
db: uniprot

uniprot A0A2J8P024 448
type: UnificationXref
id: A0A2J8P024
db: uniprot

uniprot P29120 428
type: UnificationXref
id: P29120
db: uniprot

PTHR45702:SF2
type: RelationshipXref
id: PTHR45702:SF2
db: PANTHER Family
relationship type: By Homology

PTHR45702:SF4
type: RelationshipXref
id: PTHR45702:SF4
db: PANTHER Family
relationship type: By Homology

PTHR45702:SF3
type: RelationshipXref
id: PTHR45702:SF3
db: PANTHER Family
relationship type: By Homology

Complex (APP/kinesin/ Microtubule)
type: Complex
component stoichiometry: APP s30 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: kinesin s31 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Microtubule s32 sa18 STOICHIOMETRY ID COMPLEX
component: Microtubule
component: APP
component: kinesin
feature: COMPLEX BINDING FEATURE s213 a256 645
feature: COMPLEX BINDING FEATURE s213 a256 643
feature: COMPLEX BINDING FEATURE s213 a256 641
cellular location: vesicle

Stress-activated protein kinase jnk-1
type: ProteinReference
xref: uniprot Q8WQG9 367
xref: PTHR24055:SF341
organism: Caenorhabditis elegans

uniprot E2QX69 399
type: UnificationXref
id: E2QX69
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q2TY19 238
organism: Gallus gallus

Gamma-secretase subunit pen-2
type: ProteinReference
xref: uniprot Q86BE9 176
xref: PTHR16318:SF0
organism: Drosophila melanogaster

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q5Z859 349
organism: Oryza sativa

PTHR45702:SF6
type: RelationshipXref
id: PTHR45702:SF6
db: PANTHER Family
relationship type: By Homology

Nicastrin s35 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Nicastrin
stoichiometric coefficient: 1.0

PTHR24247:SF209
type: RelationshipXref
id: PTHR24247:SF209
db: PANTHER Family
relationship type: By Homology

Muscarinic acetylcholine receptor M2 (Fragment)
type: ProteinReference
xref: uniprot Q9N2A7 125
xref: PTHR24247:SF207
organism: Pan troglodytes

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9606 18
type: UnificationXref
id: 9606
db: ncbitaxon

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q95NE7 370
organism: Pan troglodytes

uniprot Q6QI68 173
type: UnificationXref
id: Q6QI68
db: uniprot

STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_r56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 717
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 716
left: MAPK
interaction type: STATE_TRANSITION
right: MAPK

uniprot E1B8P9 249
type: UnificationXref
id: E1B8P9
db: uniprot

PTHR24247:SF207
type: RelationshipXref
id: PTHR24247:SF207
db: PANTHER Family
relationship type: By Homology

AICD s6 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

Nicastrin s13 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Nicastrin
stoichiometric coefficient: 1.0

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: uniprot P41985 120
xref: PTHR24247:SF207
organism: Bos taurus

Presenilin
type: Protein
entity reference: Presenilin
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

uniprot Q5ANK2 566
type: UnificationXref
id: Q5ANK2
db: uniprot

Neuronal acetylcholine receptor subunit alpha-7
type: ProteinReference
xref: uniprot Q05941 25
xref: PTHR18945:SF832
organism: Rattus norvegicus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 353
organism: Mus musculus

uniprot P78536 208
type: UnificationXref
id: P78536
db: uniprot

uniprot P27361 305
type: UnificationXref
id: P27361
db: uniprot

uniprot E2R2N2 251
type: UnificationXref
id: E2R2N2
db: uniprot

Presenilin
type: ProteinReference
xref: P00098
comment: ENTITY_REFERENCE_NOTES=Long Name: PresenilinSynonym: sel-12Accession: P00098
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Presenilin
member entity reference: Presenilin-2
member entity reference: Presenilin-1
member entity reference: Presenilin homolog
member entity reference: Presenilin
member entity reference: Presenilin sel-12

p3
type: ProteinReference
xref: P00086
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.p3
comment: ENTITY_REFERENCE_NOTES=Long Name: p3Synonym: Synonym not specifiedAccession: P00086
member entity reference: Amyloid-beta A4 protein
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta precursor protein

uniprot Q4JIM4 161
type: UnificationXref
id: Q4JIM4
db: uniprot

Kinesin light chain 2
type: ProteinReference
xref: uniprot Q9H0B6 478
xref: PTHR45783:SF2
organism: Homo sapiens

TRUNCATION_LEFT__Complex__APP_kinesin__Microtubule_-RIGHT__APPbeta-_Complex__kinesin_Microtubule_-_C99-_r64
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 669
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 670
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 667
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 668
left: Complex (APP/kinesin/ Microtubule)
interaction type: TRUNCATION
right: C99
right: APPbeta
right: Complex (kinesin/Microtubule)

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR10037:SF290
xref: uniprot A0A1D5PV02 48
organism: Gallus gallus

ncbitaxon 39947 325
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q8CC27 83
type: UnificationXref
id: Q8CC27
db: uniprot

Mitogen-activated protein kinase FUS3
type: ProteinReference
xref: uniprot P16892 303
xref: PTHR24055:SF158
organism: Saccharomyces cerevisiae

uniprot F1Q382 59
type: UnificationXref
id: F1Q382
db: uniprot

PARTICIPANT STOICHIOMETRY r77 690
type: Stoichiometry
physical entity: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
stoichiometric coefficient: 1.0

uniprot F7CYE3 278
type: UnificationXref
id: F7CYE3
db: uniprot

uniprot Q04592 434
type: UnificationXref
id: Q04592
db: uniprot

uniprot F1PMN2 258
type: UnificationXref
id: F1PMN2
db: uniprot

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q39024 337
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q39027 339
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q39026 338
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q39021 334
organism: Arabidopsis thaliana

MODULATION
type: RelationshipTypeVocabulary

Amyloid-beta A4 precursor protein-binding family A member 2
type: ProteinReference
xref: PTHR12345:SF12
xref: uniprot Q99767 141
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q4Q0B0 341
organism: Leishmania major

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q39023 336
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 2
type: ProteinReference
xref: uniprot Q39022 335
organism: Arabidopsis thaliana

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q62074 568
organism: Mus musculus

Neuroendocrine convertase 2 isoform 1 preproprotein
type: ProteinReference
xref: uniprot F7GNE5 410
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 291
organism: Pan troglodytes

uniprot Q7PM79 196
type: UnificationXref
id: Q7PM79
db: uniprot

uniprot D4A3U7 248
type: UnificationXref
id: D4A3U7
db: uniprot

uniprot H2R900 207
type: UnificationXref
id: H2R900
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot Q8C7N7 198
type: UnificationXref
id: Q8C7N7
db: uniprot

uniprot P56490 121
type: UnificationXref
id: P56490
db: uniprot

uniprot F6WV79 269
type: UnificationXref
id: F6WV79
db: uniprot

uniprot P46824 467
type: UnificationXref
id: P46824
db: uniprot

uniprot A0A2I3TUV7 181
type: UnificationXref
id: A0A2I3TUV7
db: uniprot

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: uniprot P10980 113
xref: PTHR24247:SF207
organism: Rattus norvegicus

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: uniprot P30372 118
xref: PTHR24247:SF207
organism: Gallus gallus

GO GO:0031982 5
type: UnificationXref
id: GO:0031982
db: GO

HETERODIMER_ASSOCIATION_LEFT__APP-_X11alpha-RIGHT__Complex__X11alpha_APP_-_r47
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 684
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 683
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 682
left: APP
left: X11alpha
interaction type: HETERODIMER_ASSOCIATION
right: Complex (X11alpha/APP)

C83
type: Protein
entity reference: C83
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot K7CBH8 528
organism: Pan troglodytes

uniprot Q9U357 180
type: UnificationXref
id: Q9U357
db: uniprot

Presenilin N-terminal fragment
type: Protein
entity reference: Presenilin N-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa31 602
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6YAB9 271
organism: Monodelphis domestica

uniprot H2R0G7 290
type: UnificationXref
id: H2R0G7
db: uniprot

ncbitaxon 6239 20
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q9M1Z5 383
type: UnificationXref
id: Q9M1Z5
db: uniprot

uniprot Q91000 443
type: UnificationXref
id: Q91000
db: uniprot

Neuronal acetylcholine receptor subunit alpha-7
type: ProteinReference
xref: uniprot Q866A2 32
xref: PTHR18945:SF832
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QP52 39
xref: PTHR47965:SF69
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QS62 289
xref: PTHR24055:SF172
organism: Pan troglodytes

uniprot Q90X07 164
type: UnificationXref
id: Q90X07
db: uniprot

PARTICIPANT STOICHIOMETRY r77 689
type: Stoichiometry
physical entity: Pen-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r77 687
type: Stoichiometry
physical entity: Nicastrin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r77 688
type: Stoichiometry
physical entity: Presenilin C-terminal fragment
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1C440 35
xref: PTHR23103:SF7
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r77 685
type: Stoichiometry
physical entity: Presenilin N-terminal fragment
stoichiometric coefficient: 1.0

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

PARTICIPANT STOICHIOMETRY r77 686
type: Stoichiometry
physical entity: Aph-1
stoichiometric coefficient: 1.0

uniprot F6TC28 457
type: UnificationXref
id: F6TC28
db: uniprot

ncbitaxon 237631 229
type: UnificationXref
id: 237631
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r51 657
type: Stoichiometry
physical entity: Complex (AICD/Fe65)
stoichiometric coefficient: 1.0

Muscarinic acetylcholine receptor M3
type: ProteinReference
xref: PTHR24247:SF183
xref: uniprot Q9ERZ3 123
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r51 656
type: Stoichiometry
physical entity: Tip60
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 658
type: Stoichiometry
physical entity: Complex (AICD/Fe65/ Tip60)
stoichiometric coefficient: 1.0

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: uniprot Q9ERZ4 124
xref: PTHR24247:SF207
organism: Mus musculus

uniprot E2REE0 400
type: UnificationXref
id: E2REE0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A4FV00 239
organism: Bos taurus

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot P63239 433
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7CYE3 278
xref: PTHR24055:SF162
organism: Xenopus tropicalis

uniprot O02194 154
type: UnificationXref
id: O02194
db: uniprot

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot H2R439 417
organism: Pan troglodytes

STATE_TRANSITION_LEFT__L_type_calcium_channels-RIGHT__L_type_calcium_channels-_re29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 700
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 701
left: L-type calcium channels
interaction type: STATE_TRANSITION
right: L-type calcium channels

uniprot Q6P023 354
type: UnificationXref
id: Q6P023
db: uniprot

ncbitaxon 9544 33
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot A8WRD7 244
type: UnificationXref
id: A8WRD7
db: uniprot

Complex (kinesin/Microtubule)
type: Complex
component stoichiometry: kinesin s11 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: Microtubule s12 sa20 STOICHIOMETRY ID COMPLEX
component: Microtubule
component: kinesin
feature: COMPLEX BINDING FEATURE s220 a268 629
feature: COMPLEX BINDING FEATURE s220 a268 631
cellular location: cytosol

uniprot Q61831 351
type: UnificationXref
id: Q61831
db: uniprot

Presenilin
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot F7A2E1 149
organism: Macaca mulatta

uniprot Q9SJG9 385
type: UnificationXref
id: Q9SJG9
db: uniprot

uniprot A7EJF2 241
type: UnificationXref
id: A7EJF2
db: uniprot

FURIN isoform 1
type: ProteinReference
xref: uniprot H2QA34 414
xref: PTHR42884:SF1
organism: Pan troglodytes

X11alpha s28 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: X11alpha
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_BACE_1-RIGHT__BACE_1-_BACE_1_pro_domain-_r62
controller: Furin

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot F1MY82 509
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RPJ2 254
xref: PTHR24055:SF356
organism: Canis lupus familiaris

uniprot A0A3Q1LTT9 236
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZTS0 273
xref: PTHR24055:SF146
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r48 679
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

Nicastrin
type: ProteinReference
xref: uniprot Q8CGU6 223
xref: PTHR21092:SF0
organism: Rattus norvegicus

Gamma-secretase subunit APH-1B isoform 1
type: ProteinReference
xref: PTHR12889:SF1
xref: uniprot H9G0E6 192
organism: Macaca mulatta

uniprot P08173 107
type: UnificationXref
id: P08173
db: uniprot

Muscarinic acetylcholine receptor M1
type: ProteinReference
xref: uniprot P12657 115
xref: PTHR24247:SF182
organism: Mus musculus

uniprot Q5F3W3 347
type: UnificationXref
id: Q5F3W3
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot H2QDQ1 525
xref: PTHR24356:SF193
organism: Pan troglodytes

Presenilin
type: ProteinReference
xref: uniprot H2R821 153
xref: PTHR10202:SF24
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r48 680
type: Stoichiometry
physical entity: C83
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 670
type: Stoichiometry
physical entity: C99
stoichiometric coefficient: 1.0

Abeta s173 a211 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 8.0

PARTICIPANT STOICHIOMETRY r48 681
type: Stoichiometry
physical entity: APPalpha
stoichiometric coefficient: 1.0

Kinesin light chain 2
type: ProteinReference
xref: uniprot O88448 464
xref: PTHR45783:SF2
organism: Mus musculus

Kinesin light chain 1
type: ProteinReference
xref: uniprot O88447 463
xref: PTHR45783:SF7
organism: Mus musculus

Tip60
type: ProteinReference
xref: P00093
standard name: HIV-1 Tat interactive protein, 60kDa
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: HIV-1 Tat interactive protein, 60kDaSynonym: HTATIP1,PLIP,TIP,TIP60,cPLA2Accession: P00093
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Tip60
member entity reference: Amyloid-beta A4 precursor protein-binding family A member 1
member entity reference: Uncharacterized protein
member entity reference: Histone acetyltransferase
member entity reference: APBA1 isoform 1
member entity reference: Amyloid-beta A4 precursor protein-binding family A member 2
member entity reference: APBA3 isoform 3
member entity reference: Histone acetyltransferase KAT5
member entity reference: Amyloid-beta A4 precursor protein-binding family A member 3
member entity reference: Amyloid beta precursor protein binding family A member 1
member entity reference: Amyloid beta precursor protein binding family A member 2

ncbitaxon 5664 342
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot A0A0G2K6H8 187
type: UnificationXref
id: A0A0G2K6H8
db: uniprot

uniprot F6TFL4 263
type: UnificationXref
id: F6TFL4
db: uniprot

uniprot K7CBH8 528
type: UnificationXref
id: K7CBH8
db: uniprot

PARTICIPANT STOICHIOMETRY r64 669
type: Stoichiometry
physical entity: Complex (kinesin/Microtubule)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 668
type: Stoichiometry
physical entity: APPbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 667
type: Stoichiometry
physical entity: Complex (APP/kinesin/ Microtubule)
stoichiometric coefficient: 1.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r42
control type: ACTIVATION
controller: L-type calcium channels

uniprot H2QDQ1 525
type: UnificationXref
id: H2QDQ1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EI48 281
xref: PTHR24055:SF393
organism: Monodelphis domestica

Mitogen-activated protein kinase p38b
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot O61443 298
organism: Drosophila melanogaster

uniprot Q02410 140
type: UnificationXref
id: Q02410
db: uniprot

uniprot O73700 69
type: UnificationXref
id: O73700
db: uniprot

Nicastrin
type: Protein
entity reference: Nicastrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa28 596
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9LM33 378
type: UnificationXref
id: Q9LM33
db: uniprot

Nicastrin
type: Protein
entity reference: Nicastrin
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Nicastrin
type: ProteinReference
xref: uniprot Q92542 225
xref: PTHR21092:SF0
organism: Homo sapiens

Presenilin-1
type: ProteinReference
xref: uniprot Q4JIM4 161
xref: PTHR10202:SF18
organism: Gallus gallus

uniprot P34722 546
type: UnificationXref
id: P34722
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

uniprot Q63538 352
type: UnificationXref
id: Q63538
db: uniprot

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 242

PARTICIPANT STOICHIOMETRY r71 707
type: Stoichiometry
physical entity: Complex (X11alpha/APP)
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r42
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 706
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 705
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

PARTICIPANT STOICHIOMETRY r71 708
type: Stoichiometry
physical entity: a269_degraded
stoichiometric coefficient: 1.0

TRUNCATION_LEFT__Complex__APP_Fe65_-RIGHT__APPbeta-_Complex__C99_Fe65_-_r46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 691
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 693
participant stoichiometry: PARTICIPANT STOICHIOMETRY r46 692
left: Complex (APP/Fe65)
interaction type: TRUNCATION
right: Complex (C99/Fe65)
right: APPbeta

PTHR24247:SF180
type: RelationshipXref
id: PTHR24247:SF180
db: PANTHER Family
relationship type: By Homology

Fe65 s5 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

PTHR24247:SF182
type: RelationshipXref
id: PTHR24247:SF182
db: PANTHER Family
relationship type: By Homology

PTHR24247:SF183
type: RelationshipXref
id: PTHR24247:SF183
db: PANTHER Family
relationship type: By Homology

uniprot P27704 308
type: UnificationXref
id: P27704
db: uniprot

uniprot F6XJP7 407
type: UnificationXref
id: F6XJP7
db: uniprot

Fe65
type: ProteinReference
xref: P00087
standard name: Amyloid precursor binding protein, family B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor binding protein, family BSynonym: RirAccession: P00087
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Fe65
member entity reference: Amyloid-beta A4 precursor protein-binding family B member 1
member entity reference: Amyloid beta precursor protein binding family B member 1
member entity reference: Uncharacterized protein

ncbitaxon 7165 175
type: UnificationXref
id: 7165
db: ncbitaxon

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24247:SF209
xref: uniprot F1P0I0 100
organism: Gallus gallus

uniprot A5PKJ4 240
type: UnificationXref
id: A5PKJ4
db: uniprot

Abeta
type: ProteinReference
xref: P00096
standard name: Beta-amyloid
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.A_beta_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: Beta-amyloidSynonym: Abeta1-40,Abeta1-42Accession: P00096
member entity reference: Amyloid-beta A4 protein
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta precursor protein

Mitogen-activated protein kinase 16
type: ProteinReference
xref: uniprot Q8W4J2 366
organism: Arabidopsis thaliana

uniprot Q9QXJ1 146
type: UnificationXref
id: Q9QXJ1
db: uniprot

Amyloid-beta A4 precursor protein-binding family A member 1
type: ProteinReference
xref: uniprot B2RUJ5 129
xref: PTHR12345:SF14
organism: Mus musculus

uniprot F6TXC2 265
type: UnificationXref
id: F6TXC2
db: uniprot

uniprot A6H7H2 449
type: UnificationXref
id: A6H7H2
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 34

Gamma-secretase subunit pen-2
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot Q9U357 180
organism: Caenorhabditis elegans

uniprot Q5PU49 567
type: UnificationXref
id: Q5PU49
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9Z1B7 390
xref: PTHR24055:SF107
organism: Mus musculus

uniprot P23188 423
type: UnificationXref
id: P23188
db: uniprot

uniprot F7D6S9 459
type: UnificationXref
id: F7D6S9
db: uniprot

uniprot Q28GF7 171
type: UnificationXref
id: Q28GF7
db: uniprot

Nicastrin
type: ProteinReference
xref: uniprot A0A2I3TWA0 218
xref: PTHR21092:SF0
organism: Pan troglodytes

Tip60
type: Protein
entity reference: Tip60
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa13 586
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3SDD9 50
type: UnificationXref
id: A0A2I3SDD9
db: uniprot

uniprot E9PTA4 182
type: UnificationXref
id: E9PTA4
db: uniprot

uniprot H2QJZ8 415
type: UnificationXref
id: H2QJZ8
db: uniprot

Aph-1
type: ProteinReference
xref: P00091
standard name: Anterior pharynx defective-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Anterior pharynx defective-1Synonym: Synonym not specifiedAccession: P00091
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Aph-1
member entity reference: Gamma-secretase subunit APH-1B isoform 1
member entity reference: Gamma-secretase subunit APH-1B
member entity reference: Aph-1 homolog A, gamma-secretase subunit
member entity reference: Gamma-secretase subunit APH-1A
member entity reference: Anterior pharynx defective 1 homolog A
member entity reference: Gamma-secretase subunit APH1-like
member entity reference: Putative gamma-secretase subunit APH-1C
member entity reference: Gamma-secretase subunit aph-1
member entity reference: AGAP009816-PA
member entity reference: Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a
member entity reference: Gamma-secretase subunit Aph-1
member entity reference: APH-1B'
member entity reference: APH1B isoform 1
member entity reference: Gamma-secretase subunit Aph-1b

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 14

MAPK4 isoform 1
type: ProteinReference
xref: PTHR24055:SF25
xref: uniprot H2QEJ2 287
organism: Pan troglodytes

uniprot K7BDV3 214
type: UnificationXref
id: K7BDV3
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F1NG47 510
xref: PTHR24356:SF159
organism: Gallus gallus

uniprot Q4Q0B0 341
type: UnificationXref
id: Q4Q0B0
db: uniprot

uniprot A0A3Q1LJZ7 235
type: UnificationXref
id: A0A3Q1LJZ7
db: uniprot

ADAM metallopeptidase domain 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot H2R900 207
organism: Pan troglodytes

uniprot Q9DCZ9 203
type: UnificationXref
id: Q9DCZ9
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot E2RGU7 504
organism: Canis lupus familiaris

uniprot Q39022 335
type: UnificationXref
id: Q39022
db: uniprot

L-type calcium channels
type: Protein
entity reference: L-type calcium channels
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot B2GV74 451
type: UnificationXref
id: B2GV74
db: uniprot

PARTICIPANT STOICHIOMETRY re29 701
type: Stoichiometry
physical entity: L-type calcium channels
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 700
type: Stoichiometry
physical entity: L-type calcium channels
stoichiometric coefficient: 1.0

uniprot Q5SN53 348
type: UnificationXref
id: Q5SN53
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__APP-RIGHT__C83-_APPalpha-_r48
controller: MDC9

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6ZKB3 272
organism: Macaca mulatta

uniprot C8V7D1 246
type: UnificationXref
id: C8V7D1
db: uniprot

TACE
type: Protein
entity reference: TACE
feature: ACTIVE 91
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F5HEA9 260
type: UnificationXref
id: F5HEA9
db: uniprot

Muscarinic acetylcholine receptor M4
type: ProteinReference
xref: PTHR24247:SF180
xref: uniprot P32211 119
organism: Mus musculus

uniprot F7HUF6 104
type: UnificationXref
id: F7HUF6
db: uniprot

uniprot Q8CHK4 215
type: UnificationXref
id: Q8CHK4
db: uniprot

kinesin
type: ProteinReference
xref: P00107
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.kinesin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Kinesin light chain 2 isoform 1
member entity reference: Kinesin light chain 2
member entity reference: KLC3 isoform 7
member entity reference: Kinesin light chain 3
member entity reference: Kinesin light chain 4
member entity reference: Uncharacterized protein
member entity reference: Kinesin light chain
member entity reference: Protein CBR-KLC-2
member entity reference: Kinesin light chain 1
member entity reference: Kinesin Light Chain
member entity reference: KLC1 protein
member entity reference: KLC4 isoform 12
member entity reference: AGAP010258-PA

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WBW6 268
xref: PTHR24055:SF356
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WV79 269
xref: PTHR24055:SF172
organism: Monodelphis domestica

Nicastrin
type: ProteinReference
xref: uniprot P57716 221
xref: PTHR21092:SF0
organism: Mus musculus

uniprot F1NG47 510
type: UnificationXref
id: F1NG47
db: uniprot

Presenilin
type: ProteinReference
xref: uniprot F6YF14 147
xref: PTHR10202:SF18
organism: Xenopus tropicalis

APPbeta
type: ProteinReference
xref: P00104
standard name: Amyloid precursor protein beta-ectodomain
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.APP_beta_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: Amino terminal fragment of amyloid precursor proteinSynonym: Synonym not specifiedAccession: P00104
member entity reference: Amyloid-beta A4 protein
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta precursor protein

uniprot O45876 193
type: UnificationXref
id: O45876
db: uniprot

ncbitaxon 3055 377
type: UnificationXref
id: 3055
db: ncbitaxon

uniprot F7ADK5 190
type: UnificationXref
id: F7ADK5
db: uniprot

uniprot F7FP03 460
type: UnificationXref
id: F7FP03
db: uniprot

C99
type: Protein
entity reference: C99
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot P87253 555
type: UnificationXref
id: P87253
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot P47811 314
organism: Mus musculus

Complex (APP/Fe65)
type: Complex
component stoichiometry: Fe65 s27 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: APP s26 sa1 STOICHIOMETRY ID COMPLEX
component: APP
component: Fe65
feature: COMPLEX BINDING FEATURE s154 a186 647
feature: COMPLEX BINDING FEATURE s154 a186 649
cellular location: cytosol

uniprot Q78EH2 441
type: UnificationXref
id: Q78EH2
db: uniprot

uniprot P16519 421
type: UnificationXref
id: P16519
db: uniprot

Fe65 s2 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 201

X11alpha s33 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: X11alpha
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 304
organism: Rattus norvegicus

APP s26 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase N1
type: ProteinReference
xref: uniprot P70268 554
xref: PTHR24356:SF246
organism: Mus musculus

Pen-2
type: ProteinReference
xref: P00089
standard name: Presenilin enhancer 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Presenilin enhancer 2Synonym: Synonym not specifiedAccession: P00089
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Pen-2
member entity reference: Gamma-secretase subunit PEN-2
member entity reference: Presenilin enhancer 2 homolog
member entity reference: AGAP008094-PA
member entity reference: Gamma-secretase subunit pen-2

uniprot Q39023 336
type: UnificationXref
id: Q39023
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 81

PARTICIPANT STOICHIOMETRY r62 671
type: Stoichiometry
physical entity: Pro-BACE-1
stoichiometric coefficient: 1.0

PKC
type: ProteinReference
xref: P00109
standard name: Protein kinase C
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.PKC
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein kinase CSynonym: Synonym not specifiedAccession: P00109
member entity reference: Serine/threonine-protein kinase N2
member entity reference: Protein kinase C-like 2
member entity reference: Protein kinase C-like 1
member entity reference: Protein kinase C iota type
member entity reference: PKN2 isoform 2
member entity reference: Uncharacterized protein
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C
member entity reference: Protein kinase C theta type
member entity reference: Protein kinase N1
member entity reference: Protein kinase C beta type
member entity reference: Serine/threonine-protein kinase N
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C, eye isozyme
member entity reference: Protein kinase C eta type
member entity reference: Serine/threonine-protein kinase N3
member entity reference: Protein kinase C-like 1B
member entity reference: Protein kinase C-like 3
member entity reference: Protein kinase C, brain isozyme
member entity reference: Protein kinase C zeta type
member entity reference: Protein kinase N3
member entity reference: Serine/threonine-protein kinase N1
member entity reference: AGAP012252-PA (Fragment)
member entity reference: PKN3 isoform 1
member entity reference: Protein kinase C gamma type (Fragment)

PARTICIPANT STOICHIOMETRY r62 673
type: Stoichiometry
physical entity: BACE-1 pro-domain
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r62 672
type: Stoichiometry
physical entity: BACE-1
stoichiometric coefficient: 1.0

Nicastrin
type: ProteinReference
xref: uniprot Q8GUM5 224
xref: PTHR21092:SF0
organism: Arabidopsis thaliana

uniprot H2R1L7 42
type: UnificationXref
id: H2R1L7
db: uniprot

Protein kinase C, eye isozyme
type: ProteinReference
xref: uniprot P13677 538
xref: PTHR24356:SF390
organism: Drosophila melanogaster

uniprot F7HT59 64
type: UnificationXref
id: F7HT59
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot Q63538 352
organism: Rattus norvegicus

uniprot C3Z299 397
type: UnificationXref
id: C3Z299
db: uniprot

uniprot A0A2I3TBK2 52
type: UnificationXref
id: A0A2I3TBK2
db: uniprot

uniprot Q7ZVK8 360
type: UnificationXref
id: Q7ZVK8
db: uniprot

uniprot P23298 542
type: UnificationXref
id: P23298
db: uniprot

Complex (X11alpha/APP)
type: Complex
component stoichiometry: APP s34 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: X11alpha s33 sa21 STOICHIOMETRY ID COMPLEX
component: APP
component: X11alpha
feature: COMPLEX BINDING FEATURE s222 a269 593
feature: COMPLEX BINDING FEATURE s222 a269 591
cellular location: lysosome

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot Q8JHF0 177
organism: Danio rerio

C99
type: ProteinReference
xref: P00106
standard name: Carboxy-terminal 99 amino acids of amyloid precursor protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: Carboxy-terminal 99 amino acids of amyloid precursor proteinSynonym: Synonym not specifiedAccession: P00106
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.C99
member entity reference: Amyloid-beta A4 protein
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta precursor protein

uniprot O08911 294
type: UnificationXref
id: O08911
db: uniprot

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 229

uniprot F1M7Y5 506
type: UnificationXref
id: F1M7Y5
db: uniprot

uniprot F7C798 277
type: UnificationXref
id: F7C798
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0D1C4Y4 228
xref: PTHR24055:SF158
organism: Ustilago maydis

uniprot F7BIC2 516
type: UnificationXref
id: F7BIC2
db: uniprot

MDC9
type: ProteinReference
xref: P00090
standard name: meltrin gamma
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: meltrin gammaSynonym: ADAM9Accession: P00090
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.MDC9
member entity reference: Disintegrin and metalloproteinase domain-containing protein 9
member entity reference: ADAM metallopeptidase domain 9
member entity reference: Uncharacterized protein

Mitogen-activated protein kinase 5
type: ProteinReference
xref: uniprot Q10N20 324
organism: Oryza sativa

Serine/threonine-protein kinase N1
type: ProteinReference
xref: uniprot A1A4I4 497
xref: PTHR24356:SF246
organism: Bos taurus

PKN2 isoform 2
type: ProteinReference
xref: uniprot H2PZC4 522
xref: PTHR24356:SF322
organism: Pan troglodytes

AICD s3 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

Nicotinic acetylcholine receptor alpha5, isoform B
type: ProteinReference
xref: uniprot Q7KT97 29
organism: Drosophila melanogaster

uniprot Q7Q3Y1 174
type: UnificationXref
id: Q7Q3Y1
db: uniprot

MAPK
type: Protein
entity reference: MAPK
feature: ACTIVE 91
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q92542 225
type: UnificationXref
id: Q92542
db: uniprot

Histone acetyltransferase KAT5
type: ProteinReference
xref: uniprot Q92993 216
xref: PTHR10615:SF183
organism: Homo sapiens

Neuroendocrine convertase 2
type: ProteinReference
xref: uniprot F6Q5F4 405
organism: Bos taurus

uniprot P09216 536
type: UnificationXref
id: P09216
db: uniprot

Stress-activated protein kinase JNK
type: ProteinReference
xref: uniprot P92208 323
xref: PTHR24055:SF341
organism: Drosophila melanogaster

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 26

PTHR12889:SF0
type: RelationshipXref
id: PTHR12889:SF0
db: PANTHER Family
relationship type: By Homology

uniprot P91197 23
type: UnificationXref
id: P91197
db: uniprot

Voltage-dependent L-type calcium channel subunit alpha-1F
type: ProteinReference
xref: PTHR45628:SF2
xref: uniprot Q9JIS7 88
organism: Mus musculus

PTHR12889:SF1
type: RelationshipXref
id: PTHR12889:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q24270 79
type: UnificationXref
id: Q24270
db: uniprot

PTHR12889:SF3
type: RelationshipXref
id: PTHR12889:SF3
db: PANTHER Family
relationship type: By Homology

PTHR23103:SF7
type: RelationshipXref
id: PTHR23103:SF7
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PTE7 480
xref: PTHR45702:SF4
organism: Monodelphis domestica

PTHR12889:SF5
type: RelationshipXref
id: PTHR12889:SF5
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Gamma-secretase subunit Aph-1b
type: ProteinReference
xref: uniprot Q8JHE9 199
xref: PTHR12889:SF5
organism: Danio rerio

uniprot H2QXZ6 526
type: UnificationXref
id: H2QXZ6
db: uniprot

Cholinergic receptor muscarinic 3
type: ProteinReference
xref: PTHR24247:SF183
xref: uniprot A0A452DI80 96
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot E1BWA3 503
organism: Gallus gallus

Presenilin N-terminal fragment
type: Protein
entity reference: Presenilin N-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa41 612
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

MDC9
type: Protein
entity reference: MDC9
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MODULATION
type: Control
xref: MODULATION
controlled: Gene transcription
controller: Complex (AICD/Fe65/ Tip60)

uniprot Q7KQK7 357
type: UnificationXref
id: Q7KQK7
db: uniprot

uniprot A0A3Q2TY19 238
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

TRUNCATION_LEFT__APP-RIGHT__C99-_APPbeta-_r84
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 652
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 651
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 653
left: APP
interaction type: TRUNCATION
right: C99
right: APPbeta

Dibasic-processing endoprotease
type: ProteinReference
xref: PTHR42884:SF14
xref: uniprot Q09175 435
organism: Schizosaccharomyces pombe

uniprot B0JYR0 396
type: UnificationXref
id: B0JYR0
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot A0A2I3RQJ8 493
organism: Pan troglodytes

TRUNCATION
type: InteractionVocabulary

uniprot Q8GUM5 224
type: UnificationXref
id: Q8GUM5
db: uniprot

Mitogen-activated protein kinase 4
type: ProteinReference
xref: PTHR24055:SF25
xref: uniprot G3V9J9 284
organism: Rattus norvegicus

Nicastrin
type: ProteinReference
xref: P00095
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Nicastrin
comment: ENTITY_REFERENCE_NOTES=Long Name: NicastrinSynonym: Synonym not specifiedAccession: P00095
member entity reference: Nicastrin

uniprot F6PTE7 480
type: UnificationXref
id: F6PTE7
db: uniprot

uniprot Q7KT97 29
type: UnificationXref
id: Q7KT97
db: uniprot

uniprot Q84UI5 362
type: UnificationXref
id: Q84UI5
db: uniprot

uniprot Q9WTY9 387
type: UnificationXref
id: Q9WTY9
db: uniprot

alpha7 nicotinic acetylcholine receptor
type: Protein
entity reference: alpha7 nicotinic acetylcholine receptor
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa14 626
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24248:SF153
xref: uniprot F1NMN4 99
organism: Gallus gallus

Microtubule
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa18 646
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Neuroendocrine convertase 2
type: ProteinReference
xref: uniprot P16519 421
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__APP-RIGHT__C83-_APPalpha-_r48
controller: TACE

Kinesin light chain 3
type: ProteinReference
xref: PTHR45783:SF1
xref: uniprot Q2TBQ9 472
organism: Bos taurus

TRANSPORT LEFT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment -RIGHT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment - r90
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 675
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 674
left: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
display name: TRANSPORT_LEFT__Complex__Nicastrin_Aph_1__Pen_2_Presenilin_N_terminal_fragment__Presenilin_C_terminal_fragment_-RIGHT__Complex__Nicastrin_Aph_1__Pen_2_Presenilin_N_terminal_fragment__Presenilin_C_terminal_fragment_-_r90
interaction type: TRANSPORT
right: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

Beta-secretase 2
type: ProteinReference
xref: uniprot Q9Y5Z0 47
organism: Homo sapiens

X11alpha
type: Protein
entity reference: X11alpha
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O62618 299
type: UnificationXref
id: O62618
db: uniprot

Presenilin C-terminal fragment
type: Protein
entity reference: Presenilin C-terminal fragment
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

uniprot Q64617 570
type: UnificationXref
id: Q64617
db: uniprot

uniprot F6XMN6 514
type: UnificationXref
id: F6XMN6
db: uniprot

APBA3 isoform 3
type: ProteinReference
xref: PTHR12345:SF9
xref: uniprot H2QEZ6 133
organism: Pan troglodytes

uniprot H2R821 153
type: UnificationXref
id: H2R821
db: uniprot

uniprot Q8TD08 365
type: UnificationXref
id: Q8TD08
db: uniprot

Aph-1 homolog A, gamma-secretase subunit
type: ProteinReference
xref: uniprot A0A3Q1MBH7 188
xref: PTHR12889:SF3
organism: Bos taurus

uniprot P49769 157
type: UnificationXref
id: P49769
db: uniprot

APPbeta
type: Protein
entity reference: APPbeta
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Complex (AICD/Fe65)
type: Complex
component stoichiometry: AICD s9 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fe65 s10 sa8 STOICHIOMETRY ID COMPLEX
component: Fe65
component: AICD
feature: COMPLEX BINDING FEATURE s217 a196 639
feature: COMPLEX BINDING FEATURE s217 a196 637
cellular location: nucleus

PARTICIPANT STOICHIOMETRY r46 693
type: Stoichiometry
physical entity: Complex (C99/Fe65)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r46 692
type: Stoichiometry
physical entity: APPbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r46 691
type: Stoichiometry
physical entity: Complex (APP/Fe65)
stoichiometric coefficient: 1.0

Kinesin light chain 4
type: ProteinReference
xref: uniprot Q9NSK0 479
xref: PTHR45783:SF6
organism: Homo sapiens

uniprot Q08BT6 562
type: UnificationXref
id: Q08BT6
db: uniprot

TACE
type: Protein
entity reference: TACE
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Furin
type: ProteinReference
xref: P00105
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Furin
comment: ENTITY_REFERENCE_NOTES=Long Name: FurinSynonym: Synonym not specifiedAccession: P00105
member entity reference: Amontillado
member entity reference: Neuroendocrine convertase 2
member entity reference: Neuroendocrine convertase 1 isoform 1 preproprotein
member entity reference: Furin
member entity reference: Uncharacterized protein
member entity reference: Proprotein convertase subtilisin/kexin type 2
member entity reference: Neuroendocrine convertase 2 isoform 1 preproprotein
member entity reference: Proprotein convertase subtilisin/kexin type 1
member entity reference: Proprotein convertase subtilisin/kexin type 6
member entity reference: Proprotein convertase subtilisin/kexin type 7
member entity reference: Neuroendocrine convertase 1
member entity reference: PCSK1 isoform 2
member entity reference: Proprotein convertase subtilisin/kexin type 4
member entity reference: PCSK2 isoform 2
member entity reference: Trans Golgi network protease furin
member entity reference: Dibasic-processing endoprotease
member entity reference: Proprotein convertase subtilisin/kexin type 5
member entity reference: FURIN isoform 1
member entity reference: Endoprotease bli-4
member entity reference: Furin, paired basic amino acid cleaving enzyme
member entity reference: AGAP002176-PA
member entity reference: Furin-like protease kpc-1
member entity reference: Furin-like protease 1, isoforms 1/1-X/2
member entity reference: Furin-like protease 2

uniprot Q9VQG2 204
type: UnificationXref
id: Q9VQG2
db: uniprot

uniprot H2QAS6 524
type: UnificationXref
id: H2QAS6
db: uniprot

lysosome
type: CellularLocationVocabulary
xref: GO GO:0005764 6

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF2
xref: uniprot G3V9W8 65
organism: Rattus norvegicus

Presenilin C terminal fragment s17 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin C-terminal fragment
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase pmk-1
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot Q17446 331
organism: Caenorhabditis elegans

uniprot Q9LV37 382
type: UnificationXref
id: Q9LV37
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: uniprot Q02956 558
xref: PTHR24356:SF170
organism: Mus musculus

Aph-1
type: Protein
entity reference: Aph-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa24 618
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

uniprot P05128 531
type: UnificationXref
id: P05128
db: uniprot

Amyloid beta precursor protein binding family B member 1
type: ProteinReference
xref: uniprot A0A2I3SB38 142
xref: PTHR14058:SF5
organism: Pan troglodytes

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot Q64617 570
organism: Rattus norvegicus

uniprot Q8R3Z5 85
type: UnificationXref
id: Q8R3Z5
db: uniprot

uniprot F6TKL3 264
type: UnificationXref
id: F6TKL3
db: uniprot

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63318 551
organism: Mus musculus

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63319 552
organism: Rattus norvegicus

uniprot O02812 293
type: UnificationXref
id: O02812
db: uniprot

uniprot E2R486 55
type: UnificationXref
id: E2R486
db: uniprot

uniprot P31152 310
type: UnificationXref
id: P31152
db: uniprot

Presenilin C-terminal fragment
type: Protein
entity reference: Presenilin C-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa42 614
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Disintegrin and metalloproteinase domain-containing protein 10
type: ProteinReference
xref: uniprot O14672 485
xref: PTHR45702:SF4
organism: Homo sapiens

Complex (AICD/Fe65)
type: Complex
component stoichiometry: AICD s3 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fe65 s5 sa6 STOICHIOMETRY ID COMPLEX
component: AICD
component: Fe65
feature: COMPLEX BINDING FEATURE s161 a195 633
feature: COMPLEX BINDING FEATURE s161 a195 635
cellular location: cytosol

PARTICIPANT STOICHIOMETRY r42 705
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Histone acetyltransferase KAT5
type: ProteinReference
xref: PTHR10615:SF183
xref: uniprot Q8CHK4 215
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r42 706
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot G3V9W8 65
type: UnificationXref
id: G3V9W8
db: uniprot

uniprot Q6Z437 356
type: UnificationXref
id: Q6Z437
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot Q61831 351
organism: Mus musculus

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__L_type_calcium_channels-RIGHT__L_type_calcium_channels-_re29
controller: Complex (alpha7 nicotinic acetylcholine receptor/Abeta)

ADAM metallopeptidase domain 10
type: ProteinReference
xref: uniprot F6QEN9 481
xref: PTHR45702:SF4
organism: Xenopus tropicalis

uniprot A0A1D5QFT0 49
type: UnificationXref
id: A0A1D5QFT0
db: uniprot

Beta-secretase 1
type: ProteinReference
xref: uniprot Q2HJ40 45
xref: PTHR47965:SF69
organism: Bos taurus

kinesin s31 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: kinesin
stoichiometric coefficient: 1.0

uniprot E2RIY9 252
type: UnificationXref
id: E2RIY9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45783:SF7
xref: uniprot F7D6S9 459
organism: Monodelphis domestica

ADAM metallopeptidase domain 9
type: ProteinReference
xref: PTHR11905:SF136
xref: uniprot E9PTA4 182
organism: Rattus norvegicus

kinesin s11 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: kinesin
stoichiometric coefficient: 1.0

Fe65
type: Protein
entity reference: Fe65
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7GL76 13
type: UnificationXref
id: F7GL76
db: uniprot

uniprot A0A3Q1MIR9 211
type: UnificationXref
id: A0A3Q1MIR9
db: uniprot

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: PTHR45628:SF10
xref: uniprot Q01815 73
organism: Mus musculus

Pen-2
type: Protein
entity reference: Pen-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa25 620
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Presenilin-1
type: ProteinReference
xref: uniprot P97887 160
xref: PTHR10202:SF18
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR45783:SF7
xref: uniprot E2RAF0 452
organism: Canis lupus familiaris

uniprot V5IKE7 392
type: UnificationXref
id: V5IKE7
db: uniprot

PARTICIPANT STOICHIOMETRY r90 674
type: Stoichiometry
physical entity: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
stoichiometric coefficient: 1.0

uniprot A0A2J8M701 94
type: UnificationXref
id: A0A2J8M701
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12345:SF12
xref: uniprot A0A1D5QT06 126
organism: Macaca mulatta

Voltage-dependent L-type calcium channel subunit alpha-1D
type: ProteinReference
xref: uniprot O73700 69
xref: PTHR45628:SF11
organism: Gallus gallus

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 2

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q9FXT7 376
organism: Chlamydomonas reinhardtii

uniprot P17200 116
type: UnificationXref
id: P17200
db: uniprot

PARTICIPANT STOICHIOMETRY r90 675
type: Stoichiometry
physical entity: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
stoichiometric coefficient: 1.0

MAPK
type: Protein
entity reference: MAPK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Disintegrin and metalloproteinase domain-containing protein 10
type: ProteinReference
xref: PTHR45702:SF4
xref: uniprot Q10741 487
organism: Bos taurus

uniprot Q7PME6 475
type: UnificationXref
id: Q7PME6
db: uniprot

uniprot Q9VAI2 489
type: UnificationXref
id: Q9VAI2
db: uniprot

uniprot Q5F3N4 488
type: UnificationXref
id: Q5F3N4
db: uniprot

uniprot Q8CGU6 223
type: UnificationXref
id: Q8CGU6
db: uniprot

uniprot H2QR92 416
type: UnificationXref
id: H2QR92
db: uniprot

uniprot Q92993 216
type: UnificationXref
id: Q92993
db: uniprot

uniprot Q01668 72
type: UnificationXref
id: Q01668
db: uniprot

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24247:SF182
xref: uniprot F1N5C5 98
organism: Bos taurus

TRUNCATION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H767 411
organism: Macaca mulatta

ADAM metallopeptidase domain 9
type: ProteinReference
xref: PTHR11905:SF136
xref: uniprot F6RT57 183
organism: Xenopus tropicalis

Amyloid-beta A4 precursor protein-binding family A member 3
type: ProteinReference
xref: uniprot O96018 138
xref: PTHR12345:SF9
organism: Homo sapiens

AICD
type: Protein
entity reference: AICD
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa5 634
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: uniprot Q9MZL7 90
xref: PTHR11824:SF17
organism: Bos taurus

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q02156 557
organism: Homo sapiens

Voltage-dependent L-type calcium channel subunit beta-2
type: ProteinReference
xref: PTHR11824:SF9
xref: uniprot Q9MZL5 89
organism: Bos taurus

APP
type: Protein
entity reference: APP
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa10 590
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

uniprot F7HC75 521
type: UnificationXref
id: F7HC75
db: uniprot

uniprot Q90ZE4 165
type: UnificationXref
id: Q90ZE4
db: uniprot

Presenilin C-terminal fragment
type: ProteinReference
xref: P00102
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.Presenilin_br_C-terminal_br_fragment
comment: ENTITY_REFERENCE_NOTES=Long Name: Presenilin C-terminal fragmentSynonym: Synonym not specifiedAccession: P00102
member entity reference: Presenilin-2
member entity reference: Presenilin-1
member entity reference: Presenilin homolog
member entity reference: Presenilin
member entity reference: Presenilin sel-12

HETERODIMER_ASSOCIATION_LEFT__Abeta-_alpha7_nicotinic_acetylcholine_receptor-RIGHT__Complex__alpha7_nicotinic_acetylcholine_receptor_Abeta_-_r58
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 713
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 712
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 711
left: alpha7 nicotinic acetylcholine receptor
left: Abeta
interaction type: HETERODIMER_ASSOCIATION
right: Complex (alpha7 nicotinic acetylcholine receptor/Abeta)

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__C83-RIGHT__AICD-_p3-_r49
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

GO GO:0005794 2
type: UnificationXref
id: GO:0005794
db: GO

uniprot Q9VJW9 490
type: UnificationXref
id: Q9VJW9
db: uniprot

uniprot F7GN93 283
type: UnificationXref
id: F7GN93
db: uniprot

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P24583 543
xref: PTHR24356:SF390
organism: Saccharomyces cerevisiae

AcetylCholine Receptor
type: ProteinReference
xref: uniprot Q18556 27
organism: Caenorhabditis elegans

uniprot F7C949 151
type: UnificationXref
id: F7C949
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E1B8P9 249
xref: PTHR24055:SF393
organism: Bos taurus

uniprot Q04759 559
type: UnificationXref
id: Q04759
db: uniprot

TRUNCATION_LEFT__C83-RIGHT__AICD-_p3-_r49
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 678
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 676
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 677
left: C83
interaction type: TRUNCATION
right: p3
right: AICD

uniprot H2RA86 291
type: UnificationXref
id: H2RA86
db: uniprot

uniprot A0A1D5QUZ8 233
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 275

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q5SN53 348
organism: Oryza sativa

uniprot Q9C5C0 371
type: UnificationXref
id: Q9C5C0
db: uniprot

uniprot H2Q3X5 105
type: UnificationXref
id: H2Q3X5
db: uniprot

uniprot P29121 429
type: UnificationXref
id: P29121
db: uniprot

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: uniprot Q5G235 172
xref: PTHR16318:SF0
organism: Bos taurus

Amontillado
type: ProteinReference
xref: uniprot Q9VBC7 444
organism: Drosophila melanogaster

Voltage-dependent L-type calcium channel subunit alpha-1S
type: ProteinReference
xref: PTHR45628:SF9
xref: uniprot Q13698 77
organism: Homo sapiens

uniprot A0A2I3REJ5 492
type: UnificationXref
id: A0A2I3REJ5
db: uniprot

ncbitaxon 7668 469
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot P46933 145
type: UnificationXref
id: P46933
db: uniprot

PTHR45783:SF7
type: RelationshipXref
id: PTHR45783:SF7
db: PANTHER Family
relationship type: By Homology

PTHR45783:SF6
type: RelationshipXref
id: PTHR45783:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45783:SF1
type: RelationshipXref
id: PTHR45783:SF1
db: PANTHER Family
relationship type: By Homology

PTHR45783:SF2
type: RelationshipXref
id: PTHR45783:SF2
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E823 279
xref: PTHR24055:SF203
organism: Monodelphis domestica

uniprot E2RE71 212
type: UnificationXref
id: E2RE71
db: uniprot

PTHR45783:SF3
type: RelationshipXref
id: PTHR45783:SF3
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__APP_Fe65_-RIGHT__APPbeta-_Complex__C99_Fe65_-_r46
controller: BACE-1

Uncharacterized protein
type: ProteinReference
xref: PTHR11905:SF136
xref: uniprot F6WJ32 184
organism: Macaca mulatta

Mitogen-activated protein kinase 4
type: ProteinReference
xref: PTHR24055:SF25
xref: uniprot P31152 310
organism: Homo sapiens

ncbitaxon 10116 26
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot Q86BE9 176
type: UnificationXref
id: Q86BE9
db: uniprot

APPbeta
type: Protein
entity reference: APPbeta
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 56

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q08BT6 562
xref: PTHR24356:SF159
organism: Xenopus tropicalis

Presenilin-2
type: ProteinReference
xref: uniprot Q90ZE4 165
xref: PTHR10202:SF24
organism: Danio rerio

uniprot Q63844 353
type: UnificationXref
id: Q63844
db: uniprot

Presenilin-1
type: ProteinReference
xref: uniprot Q9W6T7 166
xref: PTHR10202:SF18
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TQT6 513
xref: PTHR24356:SF246
organism: Macaca mulatta

uniprot F6SWI4 61
type: UnificationXref
id: F6SWI4
db: uniprot

Nicastrin s20 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Nicastrin
stoichiometric coefficient: 1.0

uniprot H2Q8K1 152
type: UnificationXref
id: H2Q8K1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CQE8 40
xref: PTHR47965:SF69
organism: Macaca mulatta

Microtubule s12 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Microtubule
stoichiometric coefficient: 1.0

Disintegrin and metalloproteinase domain-containing protein 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot P78536 208
organism: Homo sapiens

CACNB2 isoform 5
type: ProteinReference
xref: PTHR11824:SF9
xref: uniprot H2R368 67
organism: Pan troglodytes

AGAP010258-PA
type: ProteinReference
xref: uniprot Q7PME6 475
xref: PTHR45783:SF3
organism: Anopheles gambiae

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q02111 556
xref: PTHR24356:SF181
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r54 723
type: Stoichiometry
physical entity: TACE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 724
type: Stoichiometry
physical entity: TACE
stoichiometric coefficient: 1.0

a269_degraded
type: PhysicalEntity
cellular location: lysosome
comment: SPECIES_TYPE=DEGRADED

Abeta
type: Protein
entity reference: Abeta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 280
organism: Xenopus tropicalis

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF9
xref: uniprot E2R486 55
organism: Canis lupus familiaris

uniprot Q09175 435
type: UnificationXref
id: Q09175
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: TRUNCATION_LEFT__Complex__APP_Fe65_-RIGHT__APPbeta-_Complex__C99_Fe65_-_r46
controller: Cholesterol

Proprotein convertase subtilisin/kexin type 7
type: ProteinReference
xref: uniprot Q62849 438
organism: Rattus norvegicus

uniprot Q7KTF8 31
type: UnificationXref
id: Q7KTF8
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P68404 553
organism: Mus musculus

uniprot E1C440 35
type: UnificationXref
id: E1C440
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45783:SF7
xref: uniprot F6RDB4 456
organism: Ornithorhynchus anatinus

eco ECO:0000250 34
type: UnificationXref
id: ECO:0000250
db: eco

p3
type: Protein
entity reference: p3
comment: SPECIES_TYPE=PROTEIN

uniprot Q9N272 384
type: UnificationXref
id: Q9N272
db: uniprot

AcetylCholine Receptor
type: ProteinReference
xref: uniprot P91197 23
organism: Caenorhabditis elegans

uniprot Q19266 565
type: UnificationXref
id: Q19266
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot P70618 321
organism: Rattus norvegicus

uniprot F1MWR7 455
type: UnificationXref
id: F1MWR7
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7DVL1 519
xref: PTHR24356:SF214
organism: Xenopus tropicalis

C99 s1 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: C99
stoichiometric coefficient: 1.0

Nicotinic acetylcholine receptor alpha6, isoform E
type: ProteinReference
xref: uniprot Q7KTF8 31
organism: Drosophila melanogaster

Protein kinase C
type: ProteinReference
xref: uniprot H2QAS6 524
xref: PTHR24356:SF158
organism: Pan troglodytes

uniprot H2QXC2 134
type: UnificationXref
id: H2QXC2
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot Q5ANK2 566
organism: Candida albicans

Furin-like protease 2
type: ProteinReference
xref: PTHR42884:SF23
xref: uniprot P30432 431
organism: Drosophila melanogaster

C99
type: Protein
entity reference: C99
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Presenilin-2
type: ProteinReference
xref: uniprot P49810 158
xref: PTHR10202:SF24
organism: Homo sapiens

Proprotein convertase subtilisin/kexin type 4
type: ProteinReference
xref: uniprot P29121 429
organism: Mus musculus

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot P29122 430
organism: Homo sapiens

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot P29120 428
organism: Homo sapiens

AICD
type: Protein
entity reference: AICD
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa7 638
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q920H4 122
type: UnificationXref
id: Q920H4
db: uniprot

Voltage-dependent L-type calcium channel subunit beta-2
type: ProteinReference
xref: PTHR11824:SF9
xref: uniprot Q8VGC3 86
organism: Rattus norvegicus

APH-1B'
type: ProteinReference
xref: PTHR12889:SF1
xref: uniprot Q0PY50 194
organism: Rattus norvegicus

AICD s9 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05771 534
xref: PTHR24356:SF158
organism: Homo sapiens

TACE
type: ProteinReference
xref: P00092
standard name: TNF-alpha converting enzyme
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: TNF-alpha converting enzymeSynonym: ADAM17,alpha-secretaseAccession: P00092
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.TACE
member entity reference: ADAM metallopeptidase domain 17
member entity reference: Disintegrin and metalloproteinase domain-containing protein 17

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot F6XJP7 407
organism: Mus musculus

Aph-1
type: Protein
entity reference: Aph-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa39 608
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot F1MTK5 58
xref: PTHR45628:SF11
organism: Bos taurus

uniprot P49810 158
type: UnificationXref
id: P49810
db: uniprot

uniprot F7E823 279
type: UnificationXref
id: F7E823
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot A0A1D5R985 491
organism: Macaca mulatta

PTHR24055:SF25
type: RelationshipXref
id: PTHR24055:SF25
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E2RNP2 505
organism: Canis lupus familiaris

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot A0A3Q1LJZ7 235
organism: Bos taurus

Proprotein convertase subtilisin/kexin type 1
type: ProteinReference
xref: uniprot E2QX69 399
organism: Canis lupus familiaris

Kinesin light chain
type: ProteinReference
xref: PTHR45783:SF3
xref: uniprot P46824 467
organism: Drosophila melanogaster

uniprot F1MY82 509
type: UnificationXref
id: F1MY82
db: uniprot

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q13164 327
xref: PTHR24055:SF356
organism: Homo sapiens

Mitogen-activated protein kinase pmk-2
type: ProteinReference
xref: uniprot Q8MXI4 363
xref: PTHR24055:SF154
organism: Caenorhabditis elegans

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 175

uniprot Q9NZ42 179
type: UnificationXref
id: Q9NZ42
db: uniprot

Aph 1 s36 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Aph-1
stoichiometric coefficient: 1.0

uniprot E1BZF6 54
type: UnificationXref
id: E1BZF6
db: uniprot

uniprot P36583 549
type: UnificationXref
id: P36583
db: uniprot

uniprot Q9MZL5 89
type: UnificationXref
id: Q9MZL5
db: uniprot

PARTICIPANT STOICHIOMETRY r47 684
type: Stoichiometry
physical entity: Complex (X11alpha/APP)
stoichiometric coefficient: 1.0

PTHR24055:SF356
type: RelationshipXref
id: PTHR24055:SF356
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r47 682
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r47 683
type: Stoichiometry
physical entity: X11alpha
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RSB0 255
xref: PTHR24055:SF146
organism: Canis lupus familiaris

Amyloid beta precursor protein binding family B member 1
type: ProteinReference
xref: uniprot E2QWV4 144
xref: PTHR14058:SF5
organism: Canis lupus familiaris

BACE-1
type: ProteinReference
xref: P00101
standard name: Beta-site amyloid precursor protein-cleaving enzyme
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.BACE-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Beta-site amyloid precursor protein-cleaving enzymeSynonym: Asp2,asp-2,beta-secretase,memapsin,memapsin-2Accession: P00101
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Uncharacterized protein
member entity reference: Beta-secretase 1
member entity reference: Beta-secretase 2
member entity reference: BACE2 isoform 3

Furin, paired basic amino acid cleaving enzyme
type: ProteinReference
xref: uniprot E2RSE6 401
xref: PTHR42884:SF1
organism: Canis lupus familiaris

Kuzbanian-like, isoform A
type: ProteinReference
xref: uniprot Q9VAI2 489
xref: PTHR45702:SF3
organism: Drosophila melanogaster

TRUNCATION_LEFT__Complex__C99_Fe65_-RIGHT__Complex__AICD_Fe65_-_Abeta-_r45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 698
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 699
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 697
left: Complex (C99/Fe65)
interaction type: TRUNCATION
right: Abeta
right: Complex (AICD/Fe65)

uniprot Q99767 141
type: UnificationXref
id: Q99767
db: uniprot

uniprot Q3T0N5 340
type: UnificationXref
id: Q3T0N5
db: uniprot

uniprot F1P0I0 100
type: UnificationXref
id: F1P0I0
db: uniprot

Presenilin N-terminal fragment
type: ProteinReference
xref: P00088
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.Presenilin_br_N-terminal_br_fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: Presenilin N-terminal fragmentSynonym: Synonym not specifiedAccession: P00088
member entity reference: Presenilin-2
member entity reference: Presenilin-1
member entity reference: Presenilin homolog
member entity reference: Presenilin
member entity reference: Presenilin sel-12

X11alpha
type: Protein
entity reference: X11alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa9 588
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR45783:SF6
xref: uniprot F7FP03 460
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot F6V2H6 266
organism: Monodelphis domestica

uniprot Q8JHE9 199
type: UnificationXref
id: Q8JHE9
db: uniprot

Tip60
type: Protein
entity reference: Tip60
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Microtubule
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa20 632
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot P16054 539
xref: PTHR24356:SF159
organism: Mus musculus

vesicle
type: CellularLocationVocabulary
xref: GO GO:0031982 5

uniprot Q61139 437
type: UnificationXref
id: Q61139
db: uniprot

uniprot A0A1D5RKL5 394
type: UnificationXref
id: A0A1D5RKL5
db: uniprot

uniprot Q8L9G7 200
type: UnificationXref
id: Q8L9G7
db: uniprot

uniprot A0A3Q1LWJ8 237
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

uniprot O35430 135
type: UnificationXref
id: O35430
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7EJF2 241
xref: PTHR24055:SF356
organism: Sclerotinia sclerotiorum

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1PMN2 258
xref: PTHR24055:SF162
organism: Canis lupus familiaris

APP s29 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

uniprot F7A2E1 149
type: UnificationXref
id: F7A2E1
db: uniprot

uniprot Q8BWW9 574
type: UnificationXref
id: Q8BWW9
db: uniprot

uniprot Q62074 568
type: UnificationXref
id: Q62074
db: uniprot

uniprot H2QEZ6 133
type: UnificationXref
id: H2QEZ6
db: uniprot

Kinesin light chain
type: ProteinReference
xref: PTHR45783:SF3
xref: uniprot P46822 466
organism: Caenorhabditis elegans

uniprot F7GNE5 410
type: UnificationXref
id: F7GNE5
db: uniprot

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q9Z2A6 391
organism: Rattus norvegicus

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot A5PKJ4 240
xref: PTHR24055:SF356
organism: Bos taurus

uniprot H2Q9J9 191
type: UnificationXref
id: H2Q9J9
db: uniprot

uniprot P08482 108
type: UnificationXref
id: P08482
db: uniprot

Protein CBR-KLC-2
type: ProteinReference
xref: PTHR45783:SF3
xref: uniprot A8X994 450
organism: Caenorhabditis briggsae

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7FHD1 282
organism: Monodelphis domestica

ncbitaxon 284812 307
type: UnificationXref
id: 284812
db: ncbitaxon

PTHR21092:SF0
type: RelationshipXref
id: PTHR21092:SF0
db: PANTHER Family
relationship type: By Homology

uniprot P13677 538
type: UnificationXref
id: P13677
db: uniprot

uniprot Q05513 560
type: UnificationXref
id: Q05513
db: uniprot

PCSK1 isoform 2
type: ProteinReference
xref: uniprot H2QR92 416
organism: Pan troglodytes

Amyloid-beta precursor protein
type: ProteinReference
xref: uniprot P05067 36
xref: PTHR23103:SF7
organism: Homo sapiens

uniprot P05130 533
type: UnificationXref
id: P05130
db: uniprot

uniprot P41743 550
type: UnificationXref
id: P41743
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot E2RKA7 253
organism: Canis lupus familiaris

uniprot A0A1D5Q9F8 92
type: UnificationXref
id: A0A1D5Q9F8
db: uniprot

uniprot Q9LUC3 381
type: UnificationXref
id: Q9LUC3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot F5HEA9 260
organism: Phaeosphaeria nodorum

uniprot Q9WVS8 389
type: UnificationXref
id: Q9WVS8
db: uniprot

TRUNCATION_LEFT__C99-RIGHT__Abeta-_AICD-_r85
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 720
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 721
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 722
left: C99
interaction type: TRUNCATION
right: Abeta
right: AICD

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot Q63415 439
organism: Rattus norvegicus

uniprot F6RT57 183
type: UnificationXref
id: F6RT57
db: uniprot

Kinesin light chain 4
type: ProteinReference
xref: PTHR45783:SF6
xref: uniprot Q5PQM2 473
organism: Rattus norvegicus

uniprot F6XU71 62
type: UnificationXref
id: F6XU71
db: uniprot

Kinesin light chain 3
type: ProteinReference
xref: uniprot Q91W40 476
xref: PTHR45783:SF1
organism: Mus musculus

uniprot F6ZKB3 272
type: UnificationXref
id: F6ZKB3
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 18

APP s30 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q9LMM5 379
type: UnificationXref
id: Q9LMM5
db: uniprot

PTHR42884:SF1
type: RelationshipXref
id: PTHR42884:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q5A1D3 345
type: UnificationXref
id: Q5A1D3
db: uniprot

uniprot Q9WTQ0 576
type: UnificationXref
id: Q9WTQ0
db: uniprot

Gamma-secretase subunit aph-1
type: ProteinReference
xref: PTHR12889:SF0
xref: uniprot O45876 193
organism: Caenorhabditis elegans

Serine/threonine-protein kinase N1
type: ProteinReference
xref: PTHR24356:SF246
xref: uniprot Q63433 569
organism: Rattus norvegicus

Muscarinic acetylcholine receptor
type: ProteinReference
xref: uniprot F1PVZ1 102
xref: PTHR24247:SF180
organism: Canis lupus familiaris

uniprot A0A3Q1MU04 143
type: UnificationXref
id: A0A3Q1MU04
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6Y4G8 270
organism: Canis lupus familiaris

uniprot P29122 430
type: UnificationXref
id: P29122
db: uniprot

uniprot Q16659 330
type: UnificationXref
id: Q16659
db: uniprot

uniprot P30432 431
type: UnificationXref
id: P30432
db: uniprot

uniprot Q91W40 476
type: UnificationXref
id: Q91W40
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Fe65-_APP-RIGHT__Complex__APP_Fe65_-_r43
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 704
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 703
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 702
left: APP
left: Fe65
interaction type: HETERODIMER_ASSOCIATION
right: Complex (APP/Fe65)

uniprot A0A2I3RT41 446
type: UnificationXref
id: A0A2I3RT41
db: uniprot

uniprot Q9ERZ4 124
type: UnificationXref
id: Q9ERZ4
db: uniprot

Gamma-secretase subunit Aph-1
type: ProteinReference
xref: PTHR12889:SF0
xref: uniprot Q9VQG2 204
organism: Drosophila melanogaster

uniprot F7FHD1 282
type: UnificationXref
id: F7FHD1
db: uniprot

Pro-BACE-1
type: Protein
entity reference: Pro-BACE-1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Voltage-dependent L-type calcium channel subunit alpha-1D
type: ProteinReference
xref: uniprot Q99246 87
xref: PTHR45628:SF11
organism: Mus musculus

uniprot P53779 318
type: UnificationXref
id: P53779
db: uniprot

uniprot F6V2H6 266
type: UnificationXref
id: F6V2H6
db: uniprot

AGAP009816-PA
type: ProteinReference
xref: uniprot Q7PM79 196
xref: PTHR12889:SF0
organism: Anopheles gambiae

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6V332 267
organism: Macaca mulatta

uniprot H2QG41 169
type: UnificationXref
id: H2QG41
db: uniprot

uniprot J9P0J9 170
type: UnificationXref
id: J9P0J9
db: uniprot

uniprot A7F3M0 243
type: UnificationXref
id: A7F3M0
db: uniprot

uniprot O88447 463
type: UnificationXref
id: O88447
db: uniprot

X11alpha
type: Protein
entity reference: X11alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa21 592
cellular location: lysosome
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q02641 74
type: UnificationXref
id: Q02641
db: uniprot

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Pen-2
type: Protein
entity reference: Pen-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa30 600
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ADAM metallopeptidase domain 9
type: ProteinReference
xref: uniprot A0A2I3TUV7 181
xref: PTHR11905:SF136
organism: Pan troglodytes

Gamma-secretase subunit APH-1A
type: ProteinReference
xref: uniprot Q8BVF7 197
xref: PTHR12889:SF3
organism: Mus musculus

Disintegrin and metalloproteinase domain-containing protein 10
type: ProteinReference
xref: uniprot H9EQI5 484
xref: PTHR45702:SF4
organism: Macaca mulatta

uniprot H2PZC4 522
type: UnificationXref
id: H2PZC4
db: uniprot

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 95

uniprot Q9MZL7 90
type: UnificationXref
id: Q9MZL7
db: uniprot

uniprot F7CEB1 408
type: UnificationXref
id: F7CEB1
db: uniprot

uniprot G3V9J9 284
type: UnificationXref
id: G3V9J9
db: uniprot

uniprot Q91Y86 368
type: UnificationXref
id: Q91Y86
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: uniprot P09217 537
xref: PTHR24356:SF170
organism: Rattus norvegicus

uniprot Q9N2A7 125
type: UnificationXref
id: Q9N2A7
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot P09216 536
xref: PTHR24356:SF159
organism: Rattus norvegicus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P09215 535
organism: Rattus norvegicus

uniprot Q63433 569
type: UnificationXref
id: Q63433
db: uniprot

uniprot F6U002 406
type: UnificationXref
id: F6U002
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q6Z437 356
organism: Oryza sativa

uniprot Q38AI6 332
type: UnificationXref
id: Q38AI6
db: uniprot

PARTICIPANT STOICHIOMETRY r86 719
type: Stoichiometry
physical entity: Complex (X11alpha/APP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r86 718
type: Stoichiometry
physical entity: Complex (X11alpha/APP)
stoichiometric coefficient: 1.0

Proprotein convertase subtilisin/kexin type 7
type: ProteinReference
xref: uniprot A0A2I3SSR3 395
organism: Pan troglodytes

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P34722 546
xref: PTHR24356:SF347
organism: Caenorhabditis elegans

uniprot F6RA79 512
type: UnificationXref
id: F6RA79
db: uniprot

uniprot O60840 68
type: UnificationXref
id: O60840
db: uniprot

uniprot F7C0E0 518
type: UnificationXref
id: F7C0E0
db: uniprot

Protein kinase N1
type: ProteinReference
xref: uniprot A0A2I3REJ5 492
xref: PTHR24356:SF246
organism: Pan troglodytes

uniprot Q9Z0F8 209
type: UnificationXref
id: Q9Z0F8
db: uniprot

uniprot E2RNP2 505
type: UnificationXref
id: E2RNP2
db: uniprot

uniprot Q16513 564
type: UnificationXref
id: Q16513
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot F7H3B3 520
organism: Macaca mulatta

uniprot Q03481 24
type: UnificationXref
id: Q03481
db: uniprot

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot P0C865 300
xref: PTHR24055:SF356
organism: Rattus norvegicus

uniprot Q6P5G0 355
type: UnificationXref
id: Q6P5G0
db: uniprot

uniprot Q2HJ40 45
type: UnificationXref
id: Q2HJ40
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot H9EU39 527
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TACE-RIGHT__TACE-_r54
controller: PKC

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: uniprot Q02641 74
xref: PTHR11824:SF17
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot C3Z299 397
organism: Branchiostoma floridae

Histone acetyltransferase
type: ProteinReference
xref: uniprot F7AWF2 213
xref: PTHR10615:SF183
organism: Monodelphis domestica

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q3T0N5 340
xref: PTHR24055:SF107
organism: Bos taurus

uniprot G7ME71 220
type: UnificationXref
id: G7ME71
db: uniprot

uniprot F7H767 411
type: UnificationXref
id: F7H767
db: uniprot

Histone acetyltransferase KAT5
type: ProteinReference
xref: PTHR10615:SF183
xref: uniprot Q99MK2 217
organism: Rattus norvegicus

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q9WVS8 389
xref: PTHR24055:SF356
organism: Mus musculus

uniprot Q8WQG9 367
type: UnificationXref
id: Q8WQG9
db: uniprot

ncbitaxon 9913 46
type: UnificationXref
id: 9913
db: ncbitaxon

AICD
type: ProteinReference
xref: P00080
standard name: Amyloid precursor protein intracellular domain
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.AICD
comment: ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor protein intracellular domainSynonym: Synonym not specifiedAccession: P00080
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: Amyloid-beta A4 protein
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta precursor protein

uniprot A0A452DI80 96
type: UnificationXref
id: A0A452DI80
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7C0E0 518
xref: PTHR24356:SF322
organism: Macaca mulatta

uniprot O23236 296
type: UnificationXref
id: O23236
db: uniprot

uniprot Q9W6T7 166
type: UnificationXref
id: Q9W6T7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A0R4IKK9 230
organism: Danio rerio

uniprot F6QP52 39
type: UnificationXref
id: F6QP52
db: uniprot

Candida albicans
type: BioSource
xref: ncbitaxon 237561 346

Presenilin-2
type: ProteinReference
xref: uniprot Q9XT96 167
xref: PTHR10202:SF24
organism: Bos taurus

Presenilin-1
type: ProteinReference
xref: uniprot Q9XT97 168
xref: PTHR10202:SF18
organism: Bos taurus

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF392
type: RelationshipXref
id: PTHR24055:SF392
db: PANTHER Family
relationship type: By Homology

PTHR45628:SF11
type: RelationshipXref
id: PTHR45628:SF11
db: PANTHER Family
relationship type: By Homology

Amyloid-beta A4 precursor protein-binding family A member 2
type: ProteinReference
xref: uniprot P98084 139
xref: PTHR12345:SF12
organism: Mus musculus

Neuroendocrine convertase 2
type: ProteinReference
xref: uniprot P21661 422
organism: Mus musculus

Kuzbanian, isoform A
type: ProteinReference
xref: PTHR45702:SF2
xref: uniprot Q9VJW9 490
organism: Drosophila melanogaster

PTHR45628:SF10
type: RelationshipXref
id: PTHR45628:SF10
db: PANTHER Family
relationship type: By Homology

uniprot F7EK00 482
type: UnificationXref
id: F7EK00
db: uniprot

Presenilin C terminal fragment s25 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin C-terminal fragment
stoichiometric coefficient: 1.0

uniprot Q01815 73
type: UnificationXref
id: Q01815
db: uniprot

Amyloid beta precursor protein binding family A member 1
type: ProteinReference
xref: uniprot E2RG71 130
xref: PTHR12345:SF14
organism: Canis lupus familiaris

Leishmania major
type: BioSource
xref: ncbitaxon 5664 342

uniprot Q6UW60 440
type: UnificationXref
id: Q6UW60
db: uniprot

uniprot Q9H0B6 478
type: UnificationXref
id: Q9H0B6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7F3M0 243
xref: PTHR24055:SF158
organism: Sclerotinia sclerotiorum

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

uniprot P45984 313
type: UnificationXref
id: P45984
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q04759 559
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: uniprot A0A3Q1MSP9 496
xref: PTHR24356:SF170
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F7GN93 283
organism: Macaca mulatta

Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a
type: ProteinReference
xref: uniprot A0A0G2K6H8 187
xref: PTHR12889:SF3
organism: Rattus norvegicus

uniprot B2RUJ5 129
type: UnificationXref
id: B2RUJ5
db: uniprot

uniprot P05126 530
type: UnificationXref
id: P05126
db: uniprot

uniprot Q9Z1K9 210
type: UnificationXref
id: Q9Z1K9
db: uniprot

APPbeta
type: Protein
entity reference: APPbeta
comment: SPECIES_TYPE=PROTEIN

uniprot P39745 311
type: UnificationXref
id: P39745
db: uniprot

uniprot Q9ERZ3 123
type: UnificationXref
id: Q9ERZ3
db: uniprot

Serine/threonine-protein kinase N3
type: ProteinReference
xref: uniprot Q6P5Z2 571
xref: PTHR24356:SF318
organism: Homo sapiens

ADAM10
type: ProteinReference
xref: P00108
standard name: A disintegrase and metalloprotease 10
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.ADAM10
comment: ENTITY_REFERENCE_NOTES=Long Name: A disintegrase and metalloprotease 10Synonym: Synonym not specifiedAccession: P00108
member entity reference: Uncharacterized protein
member entity reference: Disintegrin and metalloproteinase domain-containing protein 10
member entity reference: ADAM metallopeptidase domain 10
member entity reference: Kuzbanian, isoform A
member entity reference: Kuzbanian-like, isoform A

PTHR24055:SF79
type: RelationshipXref
id: PTHR24055:SF79
db: PANTHER Family
relationship type: By Homology

uniprot H2R368 67
type: UnificationXref
id: H2R368
db: uniprot

Pen-2
type: Protein
entity reference: Pen-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa40 610
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot Q63415 439
type: UnificationXref
id: Q63415
db: uniprot

Aph 1 s14 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Aph-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 661
type: Stoichiometry
physical entity: Complex (kinesin/Microtubule)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 662
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 663
type: Stoichiometry
physical entity: Complex (APP/kinesin/ Microtubule)
stoichiometric coefficient: 1.0

uniprot F1PVZ1 102
type: UnificationXref
id: F1PVZ1
db: uniprot

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

uniprot P57716 221
type: UnificationXref
id: P57716
db: uniprot

uniprot P52166 159
type: UnificationXref
id: P52166
db: uniprot

AGAP002176-PA
type: ProteinReference
xref: uniprot Q7QK68 442
organism: Anopheles gambiae

GO GO:0005764 6
type: UnificationXref
id: GO:0005764
db: GO

uniprot Q9WTU6 386
type: UnificationXref
id: Q9WTU6
db: uniprot

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF11
xref: uniprot A0A1D5QFT0 49
organism: Macaca mulatta

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P79996 322
organism: Gallus gallus

Presenilin-2
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot Q61144 162
organism: Mus musculus

uniprot P12023 38
type: UnificationXref
id: P12023
db: uniprot

PTHR42884:SF14
type: RelationshipXref
id: PTHR42884:SF14
db: PANTHER Family
relationship type: By Homology

Beta-secretase 1
type: ProteinReference
xref: uniprot P56817 43
xref: PTHR47965:SF69
organism: Homo sapiens

uniprot O88448 464
type: UnificationXref
id: O88448
db: uniprot

Beta-secretase 1
type: ProteinReference
xref: uniprot P56818 44
xref: PTHR47965:SF69
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR45783:SF1
xref: uniprot F6TC28 457
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q38AI6 332
organism: Trypanosoma brucei

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot A8WR64 500
organism: Caenorhabditis briggsae

uniprot Q8S8Y9 364
type: UnificationXref
id: Q8S8Y9
db: uniprot

uniprot F7A632 515
type: UnificationXref
id: F7A632
db: uniprot

Aph-1
type: Protein
entity reference: Aph-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa29 598
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P70618 321
type: UnificationXref
id: P70618
db: uniprot

Kinesin light chain
type: ProteinReference
xref: PTHR45783:SF3
xref: uniprot Q05090 468
organism: Strongylocentrotus purpuratus

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7C798 277
xref: PTHR24055:SF109
organism: Macaca mulatta

Proprotein convertase subtilisin/kexin type 7
type: ProteinReference
xref: uniprot Q61139 437
organism: Mus musculus

uniprot Q02156 557
type: UnificationXref
id: Q02156
db: uniprot

PTHR10615:SF183
type: RelationshipXref
id: PTHR10615:SF183
db: PANTHER Family
relationship type: By Homology

ADAM metallopeptidase domain 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot E1B867 205
organism: Bos taurus

Protein kinase C-like 3
type: ProteinReference
xref: PTHR24356:SF303
xref: uniprot Q19266 565
organism: Caenorhabditis elegans

uniprot E2RG71 130
type: UnificationXref
id: E2RG71
db: uniprot

alpha7 nicotinic acetylcholine receptor
type: ProteinReference
xref: P00079
comment: ENTITY_REFERENCE_NOTES=Long Name: alpha7 nicotinic acetylcholine receptorSynonym: Synonym not specifiedAccession: P00079
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.RECEPTOR._alpha_7 nicotinic_br_acetylcholine_br_receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Uncharacterized protein
member entity reference: Neuronal acetylcholine receptor subunit alpha-7
member entity reference: Alpha8 subunit of nicotinic acetylcholine receptor
member entity reference: CHRNA7-FAM7A fusion protein
member entity reference: Nicotinic acetylcholine receptor alpha6, isoform E
member entity reference: AcetylCholine Receptor
member entity reference: Protein CBR-ACR-11
member entity reference: Nicotinic acetylcholine receptor alpha5, isoform B
member entity reference: Acetylcholine receptor subunit alpha-type acr-16

Presenilin N-terminal fragment
type: Protein
entity reference: Presenilin N-terminal fragment
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Furin
type: ProteinReference
xref: uniprot P23377 424
xref: PTHR42884:SF1
organism: Rattus norvegicus

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

Protein CBR-ACR-11
type: ProteinReference
xref: uniprot A8XGC4 7
organism: Caenorhabditis briggsae

uniprot Q9FXT7 376
type: UnificationXref
id: Q9FXT7
db: uniprot

Abeta
type: Protein
entity reference: Abeta
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__BACE_1-RIGHT__BACE_1-_r89
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r89 710
participant stoichiometry: PARTICIPANT STOICHIOMETRY r89 709
left: BACE-1
interaction type: TRANSPORT
right: BACE-1

Alzheimer disease-amyloid secretase pathway
type: Pathway
pathway component: TRUNCATION_LEFT__C83-RIGHT__AICD-_p3-_r49
pathway component: HETERODIMER_ASSOCIATION_LEFT__APP-_X11alpha-RIGHT__Complex__X11alpha_APP_-_r47
pathway component: TRUNCATION_LEFT__Complex__APP_Fe65_-RIGHT__APPbeta-_Complex__C99_Fe65_-_r46
pathway component: TRANSPORT_LEFT__BACE_1-RIGHT__BACE_1-_r89
pathway component: TRUNCATION_LEFT__Complex__APP_kinesin__Microtubule_-RIGHT__APPbeta-_Complex__kinesin_Microtubule_-_C99-_r64
pathway component: STATE_TRANSITION_LEFT__Complex__X11alpha_APP_-RIGHT__a269_degraded-_r71
pathway component: HETERODIMER ASSOCIATION LEFT Presenilin N terminal fragment- Aph 1- Nicastrin- Presenilin C terminal fragment- Pen 2-RIGHT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment - r77
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__kinesin_Microtubule_-_APP-RIGHT__Complex__APP_kinesin__Microtubule_-_r68
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r42
pathway component: TRANSPORT_LEFT__Complex__X11alpha_APP_-RIGHT__Complex__X11alpha_APP_-_r86
pathway component: MODULATION
pathway component: TRANSPORT_LEFT__Complex__AICD_Fe65_-RIGHT__Complex__AICD_Fe65_-_r87
pathway component: STATE_TRANSITION_LEFT__L_type_calcium_channels-RIGHT__L_type_calcium_channels-_re29
pathway component: TRANSPORT LEFT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment -RIGHT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment - r90
pathway component: STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_r56
pathway component: TRUNCATION_LEFT__APP-RIGHT__C83-_APPalpha-_r48
pathway component: TRUNCATION_LEFT__Pro_BACE_1-RIGHT__BACE_1-_BACE_1_pro_domain-_r62
pathway component: HETERODIMER_ASSOCIATION_LEFT__Abeta-_alpha7_nicotinic_acetylcholine_receptor-RIGHT__Complex__alpha7_nicotinic_acetylcholine_receptor_Abeta_-_r58
pathway component: TRUNCATION_LEFT__C99-RIGHT__Abeta-_AICD-_r85
pathway component: TRUNCATION_LEFT__Complex__C99_Fe65_-RIGHT__Complex__AICD_Fe65_-_Abeta-_r45
pathway component: TRUNCATION_LEFT__C99-RIGHT__AICD-_Abeta-_r65
pathway component: STATE_TRANSITION_LEFT__Abeta-RIGHT__Abeta-_r50
pathway component: TRUNCATION_LEFT__Presenilin-RIGHT__Presenilin_N_terminal_fragment-_Presenilin_C_terminal_fragment-_r76
pathway component: STATE_TRANSITION_LEFT__TACE-RIGHT__TACE-_r54
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r53
pathway component: HETERODIMER_ASSOCIATION_LEFT__Tip60-_Complex__AICD_Fe65_-RIGHT__Complex__AICD_Fe65__Tip60_-_r51
pathway component: HETERODIMER_ASSOCIATION_LEFT__Fe65-_APP-RIGHT__Complex__APP_Fe65_-_r43
pathway component: TRUNCATION_LEFT__APP-RIGHT__C99-_APPbeta-_r84
xref: PANTHER Pathway P00003 1
comment: MODEL_NOTES=Panther Pathway: P00003The amyloid precursor protein can be cleaved by multiple enzymes. Sequential cleavage by alpha-secretase (TACE, ADAM10 or MDC9) followed by gamma-secretase (presenilin complex) results in the formation of benign p3. By contrast, cleavage by beta-secretase (BACE) followed by gamma-secretase cleavage produces amyloid-beta, a fragment which assembles into senile plaques in Alzheimer's disease patients' brains. Medline=10806097Medline=11484003Medline=11520976Medline=12142279Medline=14598312PMID: 10806097PMID: 11484003PMID: 11520976PMID: 12142279PMID: 14598312

Muscarinic acetylcholine receptor M5
type: ProteinReference
xref: PTHR24247:SF209
xref: uniprot P08911 111
organism: Rattus norvegicus

Muscarinic acetylcholine receptor M5
type: ProteinReference
xref: uniprot P08912 112
xref: PTHR24247:SF209
organism: Homo sapiens

ADAM metallopeptidase domain 10
type: ProteinReference
xref: PTHR45702:SF4
xref: uniprot F7EK00 482
organism: Ornithorhynchus anatinus

uniprot Q02111 556
type: UnificationXref
id: Q02111
db: uniprot

uniprot Q61144 162
type: UnificationXref
id: Q61144
db: uniprot

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

uniprot Q39024 337
type: UnificationXref
id: Q39024
db: uniprot

Serine/threonine-protein kinase N
type: ProteinReference
xref: PTHR24356:SF210
xref: uniprot A1Z7T0 498
organism: Drosophila melanogaster

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa4 580
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P28840 426
type: UnificationXref
id: P28840
db: uniprot

KLC1 protein
type: ProteinReference
xref: PTHR45783:SF7
xref: uniprot A6H7H2 449
organism: Bos taurus

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 16

uniprot F6R8N9 262
type: UnificationXref
id: F6R8N9
db: uniprot

uniprot K7CEN2 292
type: UnificationXref
id: K7CEN2
db: uniprot

uniprot A0A0R4IKK9 230
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q15759 328
xref: PTHR24055:SF109
organism: Homo sapiens

uniprot A0A1D5PAB2 445
type: UnificationXref
id: A0A1D5PAB2
db: uniprot

uniprot Q13443 185
type: UnificationXref
id: Q13443
db: uniprot

uniprot E2RCD4 453
type: UnificationXref
id: E2RCD4
db: uniprot

Aph 1 s21 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Aph-1
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q7KQK7 357
xref: PTHR24055:SF189
organism: Plasmodium falciparum

X11alpha
type: ProteinReference
xref: P00084
standard name: Amyloid beta A4 precursor protein-binding family A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.X11_alpha_
comment: ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor binding protein, family ASynonym: D9S411E,MINT1Accession: P00084
member entity reference: Amyloid-beta A4 precursor protein-binding family A member 1
member entity reference: Uncharacterized protein
member entity reference: APBA1 isoform 1
member entity reference: APBA3 isoform 3
member entity reference: Amyloid-beta A4 precursor protein-binding family A member 2
member entity reference: Amyloid-beta A4 precursor protein-binding family A member 3
member entity reference: Amyloid beta precursor protein binding family A member 1
member entity reference: Amyloid beta precursor protein binding family A member 2

TRUNCATION_LEFT__Pro_BACE_1-RIGHT__BACE_1-_BACE_1_pro_domain-_r62
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 671
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 673
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 672
left: Pro-BACE-1
interaction type: TRUNCATION
right: BACE-1
right: BACE-1 pro-domain

uniprot F1PXS7 259
type: UnificationXref
id: F1PXS7
db: uniprot

uniprot F6WBW6 268
type: UnificationXref
id: F6WBW6
db: uniprot

eco ECO:0000304 95
type: UnificationXref
id: ECO:0000304
db: eco

uniprot F7EI48 281
type: UnificationXref
id: F7EI48
db: uniprot

Muscarinic acetylcholine receptor M4
type: ProteinReference
xref: PTHR24247:SF180
xref: uniprot P08173 107
organism: Homo sapiens

Muscarinic acetylcholine receptor M2
type: ProteinReference
xref: PTHR24247:SF207
xref: uniprot P08172 106
organism: Homo sapiens

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa8 640
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot O15264 295
organism: Homo sapiens

uniprot H2Q9G3 286
type: UnificationXref
id: H2Q9G3
db: uniprot

uniprot A0A2I3TLB5 447
type: UnificationXref
id: A0A2I3TLB5
db: uniprot

uniprot Q9NSK0 479
type: UnificationXref
id: Q9NSK0
db: uniprot

uniprot H2Q573 66
type: UnificationXref
id: H2Q573
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot F6TFL4 263
organism: Monodelphis domestica

Anterior pharynx defective 1 homolog A
type: ProteinReference
xref: uniprot E2R5H5 189
xref: PTHR12889:SF3
organism: Canis lupus familiaris

uniprot A0A2I3RZ31 234
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

Muscarinic acetylcholine receptor
type: ProteinReference
xref: uniprot F7DJJ2 103
xref: PTHR24247:SF207
organism: Monodelphis domestica

Amyloid beta precursor protein binding family A member 2
type: ProteinReference
xref: PTHR12345:SF12
xref: uniprot A0A2I3TBF6 127
organism: Pan troglodytes

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot F6RA79 512
organism: Monodelphis domestica

APP
type: Protein
entity reference: APP
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Abeta-RIGHT__Abeta-_r50
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 660
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 659
left: Abeta
interaction type: STATE_TRANSITION
right: Abeta

uniprot Q8W4J2 366
type: UnificationXref
id: Q8W4J2
db: uniprot

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5F3N4 488
xref: PTHR45702:SF4
organism: Gallus gallus

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9LMM5 379
organism: Arabidopsis thaliana

uniprot O15264 295
type: UnificationXref
id: O15264
db: uniprot

P00090
type: UnificationXref
id: P00090
db: PANTHER Pathway Component

uniprot P16892 303
type: UnificationXref
id: P16892
db: uniprot

P00093
type: UnificationXref
id: P00093
db: PANTHER Pathway Component

P00094
type: UnificationXref
id: P00094
db: PANTHER Pathway Component

P00091
type: UnificationXref
id: P00091
db: PANTHER Pathway Component

P00092
type: UnificationXref
id: P00092
db: PANTHER Pathway Component

P00097
type: UnificationXref
id: P00097
db: PANTHER Pathway Component

P00098
type: UnificationXref
id: P00098
db: PANTHER Pathway Component

P00095
type: UnificationXref
id: P00095
db: PANTHER Pathway Component

P00096
type: UnificationXref
id: P00096
db: PANTHER Pathway Component

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7B5L8 274
xref: PTHR24055:SF172
organism: Ornithorhynchus anatinus

ACTIVE 91
type: EntityFeature
comment: Active state

uniprot F1MVV5 256
type: UnificationXref
id: F1MVV5
db: uniprot

ncbitaxon 8364 148
type: UnificationXref
id: 8364
db: ncbitaxon

P00099
type: UnificationXref
id: P00099
db: PANTHER Pathway Component

uniprot Q494W8 28
type: UnificationXref
id: Q494W8
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot Q5F3W3 347
organism: Gallus gallus

Presenilin-1
type: ProteinReference
xref: uniprot P49768 156
xref: PTHR10202:SF18
organism: Homo sapiens

APPalpha
type: ProteinReference
xref: P00097
standard name: Amyloid precursor protein alpha ectodomain
comment: ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor protein alpha ectodomainSynonym: Synonym not specifiedAccession: P00097
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.APP_alpha_
member entity reference: Amyloid-beta A4 protein
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta precursor protein

Presenilin-1
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot P49769 157
organism: Mus musculus

uniprot P36582 548
type: UnificationXref
id: P36582
db: uniprot

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot G5E577 285
organism: Bos taurus

Amyloid-beta A4 protein
type: ProteinReference
xref: uniprot P08592 37
xref: PTHR23103:SF7
organism: Rattus norvegicus

uniprot P30372 118
type: UnificationXref
id: P30372
db: uniprot

uniprot Q08289 76
type: UnificationXref
id: Q08289
db: uniprot

uniprot O96018 138
type: UnificationXref
id: O96018
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 33

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__C99-RIGHT__AICD-_Abeta-_r65
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

C99
type: Protein
entity reference: C99
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa3 578
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

APP
type: Protein
entity reference: APP
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q80Y86 361
xref: PTHR24055:SF79
organism: Mus musculus

Kinesin light chain 2
type: ProteinReference
xref: uniprot A0A2I3RT41 446
xref: PTHR45783:SF2
organism: Pan troglodytes

ncbitaxon 7955 81
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot F6RDB4 456
type: UnificationXref
id: F6RDB4
db: uniprot

uniprot P10980 113
type: UnificationXref
id: P10980
db: uniprot

BACE-1
type: Protein
entity reference: BACE-1
feature: ACTIVE 91
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Nicastrin
type: Protein
entity reference: Nicastrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa23 616
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

BACE2 isoform 3
type: ProteinReference
xref: uniprot H2R1L7 42
organism: Pan troglodytes

PTHR24248:SF155
type: RelationshipXref
id: PTHR24248:SF155
db: PANTHER Family
relationship type: By Homology

Kinesin light chain 4
type: ProteinReference
xref: PTHR45783:SF6
xref: uniprot Q9DBS5 477
organism: Mus musculus

Complex (X11alpha/APP)
type: Complex
component stoichiometry: X11alpha s28 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: APP s29 sa10 STOICHIOMETRY ID COMPLEX
component: X11alpha
component: APP
feature: COMPLEX BINDING FEATURE s165 a200 587
feature: COMPLEX BINDING FEATURE s165 a200 589
cellular location: cytosol

P00079
type: UnificationXref
id: P00079
db: PANTHER Pathway Component

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q9DGD9 373
organism: Danio rerio

Fe65 s10 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot Q9CQR7 178
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r84 651
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

uniprot P08592 37
type: UnificationXref
id: P08592
db: uniprot

Furin, paired basic amino acid cleaving enzyme
type: ProteinReference
xref: uniprot F7CEB1 408
xref: PTHR42884:SF1
organism: Xenopus tropicalis

Aph-1
type: Protein
entity reference: Aph-1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Muscarinic acetylcholine receptor M5
type: ProteinReference
xref: uniprot P56490 121
xref: PTHR24247:SF209
organism: Macaca mulatta

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot P41743 550
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r84 653
type: Stoichiometry
physical entity: APPbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r84 652
type: Stoichiometry
physical entity: C99
stoichiometric coefficient: 1.0

PTHR24248:SF153
type: RelationshipXref
id: PTHR24248:SF153
db: PANTHER Family
relationship type: By Homology

uniprot P08172 106
type: UnificationXref
id: P08172
db: uniprot

uniprot P23377 424
type: UnificationXref
id: P23377
db: uniprot

P00080
type: UnificationXref
id: P00080
db: PANTHER Pathway Component

uniprot Q7QCP8 573
type: UnificationXref
id: Q7QCP8
db: uniprot

P00081
type: UnificationXref
id: P00081
db: PANTHER Pathway Component

P00082
type: UnificationXref
id: P00082
db: PANTHER Pathway Component

P00083
type: UnificationXref
id: P00083
db: PANTHER Pathway Component

uniprot P17252 540
type: UnificationXref
id: P17252
db: uniprot

Voltage-dependent L-type calcium channel subunit beta-2
type: ProteinReference
xref: PTHR11824:SF9
xref: uniprot Q08289 76
organism: Homo sapiens

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE1 374
organism: Danio rerio

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE2 375
organism: Danio rerio

P00088
type: UnificationXref
id: P00088
db: PANTHER Pathway Component

uniprot H2Q8F2 523
type: UnificationXref
id: H2Q8F2
db: uniprot

P00089
type: UnificationXref
id: P00089
db: PANTHER Pathway Component

Calcium voltage-gated channel auxiliary subunit beta 1
type: ProteinReference
xref: PTHR11824:SF17
xref: uniprot A0A2I3TBK2 52
organism: Pan troglodytes

P00084
type: UnificationXref
id: P00084
db: PANTHER Pathway Component

P00085
type: UnificationXref
id: P00085
db: PANTHER Pathway Component

P00086
type: UnificationXref
id: P00086
db: PANTHER Pathway Component

P00087
type: UnificationXref
id: P00087
db: PANTHER Pathway Component

Proprotein convertase subtilisin/kexin type 7
type: ProteinReference
xref: uniprot E2REE0 400
organism: Canis lupus familiaris

HETERODIMER_ASSOCIATION_LEFT__Complex__kinesin_Microtubule_-_APP-RIGHT__Complex__APP_kinesin__Microtubule_-_r68
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 662
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 663
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 661
left: APP
left: Complex (kinesin/Microtubule)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (APP/kinesin/ Microtubule)

BACE-1
type: Protein
entity reference: BACE-1
feature: ACTIVE 91
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9VC27 226
type: UnificationXref
id: Q9VC27
db: uniprot

PTHR24248:SF142
type: RelationshipXref
id: PTHR24248:SF142
db: PANTHER Family
relationship type: By Homology

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot F1Q382 59
xref: PTHR45628:SF10
organism: Canis lupus familiaris

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Protein kinase C
type: ProteinReference
xref: uniprot F7HC75 521
xref: PTHR24356:SF181
organism: Macaca mulatta

uniprot Q5Z859 349
type: UnificationXref
id: Q5Z859
db: uniprot

uniprot F7H3B3 520
type: UnificationXref
id: F7H3B3
db: uniprot

ncbitaxon 9615 56
type: UnificationXref
id: 9615
db: ncbitaxon

Mitogen-activated protein kinase 4
type: ProteinReference
xref: PTHR24055:SF25
xref: uniprot F1MVV5 256
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r76 694
type: Stoichiometry
physical entity: Presenilin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 695
type: Stoichiometry
physical entity: Presenilin N-terminal fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 696
type: Stoichiometry
physical entity: Presenilin C-terminal fragment
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR11824:SF9
xref: uniprot F6SWI4 61
organism: Macaca mulatta

C83
type: ProteinReference
xref: P00100
standard name: Carboxy-terminal 83 amino acids of amyloid precursor protein
comment: ENTITY_REFERENCE_NOTES=Long Name: Carboxy-terminal 83 amino acids of amyloid precursor proteinSynonym: Synonym not specifiedAccession: P00100
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.C83
member entity reference: Amyloid-beta A4 protein
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta precursor protein

Aph-1 homolog A, gamma-secretase subunit
type: ProteinReference
xref: uniprot F7ADK5 190
xref: PTHR12889:SF3
organism: Monodelphis domestica

STATE_TRANSITION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HBW2 63
xref: PTHR11824:SF17
organism: Macaca mulatta

uniprot F1MCK3 97
type: UnificationXref
id: F1MCK3
db: uniprot

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 377

Kinesin light chain 1
type: ProteinReference
xref: PTHR45783:SF7
xref: uniprot Q07866 470
organism: Homo sapiens

Kinesin light chain 2
type: ProteinReference
xref: uniprot B2GV74 451
xref: PTHR45783:SF2
organism: Rattus norvegicus

ncbitaxon 44689 344
type: UnificationXref
id: 44689
db: ncbitaxon

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot Q23316 222
organism: Caenorhabditis elegans

APP
type: Protein
entity reference: APP
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa22 594
cellular location: lysosome
comment: SPECIES_TYPE=PROTEIN

MAPK6 isoform 1
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot H2Q9G3 286
organism: Pan troglodytes

Amyloid beta precursor protein binding family A member 1
type: ProteinReference
xref: uniprot A0A3Q1MLH9 128
xref: PTHR12345:SF14
organism: Bos taurus

Mitogen-activated protein kinase mpk-1
type: ProteinReference
xref: uniprot P39745 311
xref: PTHR24055:SF158
organism: Caenorhabditis elegans

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot F1MFR6 403
organism: Bos taurus

uniprot Q02956 558
type: UnificationXref
id: Q02956
db: uniprot

Mitogen-activated protein kinase 4
type: ProteinReference
xref: PTHR24055:SF25
xref: uniprot Q6P5G0 355
organism: Mus musculus

Nicastrin
type: Protein
entity reference: Nicastrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa38 606
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa6 636
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P63086 320
type: UnificationXref
id: P63086
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 8

uniprot A8KBH6 499
type: UnificationXref
id: A8KBH6
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 20

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot H2Q573 66
xref: PTHR45628:SF10
organism: Pan troglodytes

uniprot Q8JHF0 177
type: UnificationXref
id: Q8JHF0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GL76 13
organism: Monodelphis domestica

APH1B isoform 1
type: ProteinReference
xref: PTHR12889:SF1
xref: uniprot H2Q9J9 191
organism: Pan troglodytes

Acetylcholine receptor subunit alpha-type acr-16
type: ProteinReference
xref: uniprot P48180 19
organism: Caenorhabditis elegans

PTHR42884:SF23
type: RelationshipXref
id: PTHR42884:SF23
db: PANTHER Family
relationship type: By Homology

uniprot F6WJ32 184
type: UnificationXref
id: F6WJ32
db: uniprot

ncbitaxon 6238 8
type: UnificationXref
id: 6238
db: ncbitaxon

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O08911 294
organism: Mus musculus

uniprot P63319 552
type: UnificationXref
id: P63319
db: uniprot

uniprot A0A1D5R985 491
type: UnificationXref
id: A0A1D5R985
db: uniprot

uniprot A0A3Q1MSP9 496
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

ncbitaxon 321614 261
type: UnificationXref
id: 321614
db: ncbitaxon

Muscarinic acetylcholine receptor
type: ProteinReference
xref: uniprot F7HUF6 104
xref: PTHR24248:SF155
organism: Macaca mulatta

ADAM metallopeptidase domain 10
type: ProteinReference
xref: uniprot H2Q9I4 483
xref: PTHR45702:SF4
organism: Pan troglodytes

uniprot F6QXA9 511
type: UnificationXref
id: F6QXA9
db: uniprot

Amyloid-beta A4 precursor protein-binding family B member 1
type: ProteinReference
xref: uniprot Q9QXJ1 146
xref: PTHR14058:SF5
organism: Mus musculus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_r56
control type: ACTIVATION
controller: alpha7 nicotinic acetylcholine receptor

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot D4A3U7 248
xref: PTHR24055:SF109
organism: Rattus norvegicus

uniprot Q8MQA1 84
type: UnificationXref
id: Q8MQA1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2R2N2 251
xref: PTHR24055:SF203
organism: Canis lupus familiaris

Beta-secretase 1
type: ProteinReference
xref: uniprot H2Q4U8 41
xref: PTHR47965:SF69
organism: Pan troglodytes

Fe65 s27 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

uniprot A4FV00 239
type: UnificationXref
id: A4FV00
db: uniprot

Muscarinic acetylcholine receptors
type: Protein
entity reference: Muscarinic acetylcholine receptors
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5PXC6 231
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

uniprot Q18556 27
type: UnificationXref
id: Q18556
db: uniprot

CHRNA7-FAM7A fusion protein
type: ProteinReference
xref: uniprot Q494W8 28
organism: Homo sapiens

uniprot P08483 109
type: UnificationXref
id: P08483
db: uniprot

Muscarinic acetylcholine receptors
type: ProteinReference
xref: P00083
comment: ENTITY_REFERENCE_NOTES=Long Name: Muscarinic acetylcholine receptorsSynonym: Synonym not specifiedAccession: P00083
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.RECEPTOR.Muscarinic_br_acetylcholine_br_receptors
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Muscarinic acetylcholine receptor
member entity reference: Muscarinic acetylcholine receptor M5
member entity reference: Muscarinic acetylcholine receptor M3
member entity reference: Muscarinic acetylcholine receptor M1
member entity reference: Cholinergic receptor muscarinic 3
member entity reference: Muscarinic acetylcholine receptor M2
member entity reference: Muscarinic acetylcholine receptor M4
member entity reference: Muscarinic acetylcholine receptor M2 (Fragment)

uniprot Q9XT96 167
type: UnificationXref
id: Q9XT96
db: uniprot

Neuroendocrine convertase 1 isoform 1 preproprotein
type: ProteinReference
xref: uniprot H9FVB9 418
organism: Macaca mulatta

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

uniprot H2QEJ2 287
type: UnificationXref
id: H2QEJ2
db: uniprot

uniprot P48180 19
type: UnificationXref
id: P48180
db: uniprot

Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
type: Complex
component stoichiometry: Pen 2 s23 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: Nicastrin s20 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: Aph 1 s21 sa39 STOICHIOMETRY ID COMPLEX
component stoichiometry: Presenilin N terminal fragment s24 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: Presenilin C terminal fragment s25 sa42 STOICHIOMETRY ID COMPLEX
component: Pen-2
component: Presenilin C-terminal fragment
component: Presenilin N-terminal fragment
component: Nicastrin
component: Aph-1
feature: COMPLEX BINDING FEATURE s254 a313 607
feature: COMPLEX BINDING FEATURE s254 a313 609
feature: ACTIVE 91
feature: COMPLEX BINDING FEATURE s254 a313 605
feature: COMPLEX BINDING FEATURE s254 a313 613
feature: COMPLEX BINDING FEATURE s254 a313 611
cellular location: vesicle

Presenilin C-terminal fragment
type: Protein
entity reference: Presenilin C-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa27 624
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q90XF2 575
organism: Danio rerio

ncbitaxon 185431 333
type: UnificationXref
id: 185431
db: ncbitaxon

uniprot Q8BVF7 197
type: UnificationXref
id: Q8BVF7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot C8V7D1 246
xref: PTHR24055:SF158
organism: Emericella nidulans

uniprot Q8WW43 202
type: UnificationXref
id: Q8WW43
db: uniprot

Neuronal acetylcholine receptor subunit alpha-7
type: ProteinReference
xref: uniprot P36544 17
xref: PTHR18945:SF832
organism: Homo sapiens

uniprot Q80Y86 361
type: UnificationXref
id: Q80Y86
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 398

uniprot P27638 306
type: UnificationXref
id: P27638
db: uniprot

Nicastrin
type: ProteinReference
xref: uniprot G7ME71 220
xref: PTHR21092:SF0
organism: Macaca mulatta

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot P45983 312
organism: Homo sapiens

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P45984 313
xref: PTHR24055:SF172
organism: Homo sapiens

uniprot Q08DH4 471
type: UnificationXref
id: Q08DH4
db: uniprot

PARTICIPANT STOICHIOMETRY r45 699
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 698
type: Stoichiometry
physical entity: Complex (AICD/Fe65)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 697
type: Stoichiometry
physical entity: Complex (C99/Fe65)
stoichiometric coefficient: 1.0

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

uniprot F6REU0 60
type: UnificationXref
id: F6REU0
db: uniprot

TRANSPORT_LEFT__Complex__AICD_Fe65_-RIGHT__Complex__AICD_Fe65_-_r87
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 714
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 715
left: Complex (AICD/Fe65)
interaction type: TRANSPORT
right: Complex (AICD/Fe65)

P00104
type: UnificationXref
id: P00104
db: PANTHER Pathway Component

Amyloid-beta A4 protein
type: ProteinReference
xref: uniprot P12023 38
xref: PTHR23103:SF7
organism: Mus musculus

P00106
type: UnificationXref
id: P00106
db: PANTHER Pathway Component

P00105
type: UnificationXref
id: P00105
db: PANTHER Pathway Component

P00108
type: UnificationXref
id: P00108
db: PANTHER Pathway Component

P00107
type: UnificationXref
id: P00107
db: PANTHER Pathway Component

Disintegrin and metalloproteinase domain-containing protein 10
type: ProteinReference
xref: uniprot O35598 486
xref: PTHR45702:SF4
organism: Mus musculus

P00109
type: UnificationXref
id: P00109
db: PANTHER Pathway Component

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F1M7Y5 506
organism: Rattus norvegicus

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q9M1Z5 383
organism: Arabidopsis thaliana

uniprot Q8VGC3 86
type: UnificationXref
id: Q8VGC3
db: uniprot

uniprot P0C865 300
type: UnificationXref
id: P0C865
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot F7BIC2 516
xref: PTHR24356:SF159
organism: Macaca mulatta

uniprot Q16512 563
type: UnificationXref
id: Q16512
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12345:SF9
xref: uniprot F6YCI6 132
organism: Macaca mulatta

uniprot Q10741 487
type: UnificationXref
id: Q10741
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MU04 143
xref: PTHR14058:SF5
organism: Bos taurus

uniprot P11229 114
type: UnificationXref
id: P11229
db: uniprot

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P05129 532
xref: PTHR24356:SF162
organism: Homo sapiens

Presenilin enhancer 2 homolog
type: ProteinReference
xref: uniprot H2QG41 169
xref: PTHR16318:SF0
organism: Pan troglodytes

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05126 530
xref: PTHR24356:SF158
organism: Bos taurus

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05128 531
organism: Bos taurus

Serine/threonine-protein kinase WNK2
type: ProteinReference
xref: uniprot Q8S8Y9 364
organism: Arabidopsis thaliana

uniprot P45983 312
type: UnificationXref
id: P45983
db: uniprot

Proprotein convertase subtilisin/kexin type 2
type: ProteinReference
xref: uniprot F7G632 409
organism: Monodelphis domestica

Presenilin-2
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot O88777 155
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r89 709
type: Stoichiometry
physical entity: BACE-1
stoichiometric coefficient: 1.0

uniprot O88888 137
type: UnificationXref
id: O88888
db: uniprot

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P20444 541
xref: PTHR24356:SF193
organism: Mus musculus

STATE_TRANSITION_LEFT__Complex__X11alpha_APP_-RIGHT__a269_degraded-_r71
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 707
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 708
left: Complex (X11alpha/APP)
interaction type: STATE_TRANSITION
right: a269_degraded

Mitogen-activated protein kinase 19
type: ProteinReference
xref: uniprot Q9LUC3 381
organism: Arabidopsis thaliana

Protein kinase C, brain isozyme
type: ProteinReference
xref: uniprot P05130 533
xref: PTHR24356:SF390
organism: Drosophila melanogaster

uniprot F7C2C6 276
type: UnificationXref
id: F7C2C6
db: uniprot

PARTICIPANT STOICHIOMETRY r89 710
type: Stoichiometry
physical entity: BACE-1
stoichiometric coefficient: 1.0

PTHR11824:SF9
type: RelationshipXref
id: PTHR11824:SF9
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase spk1
type: ProteinReference
xref: uniprot P27638 306
xref: PTHR24055:SF158
organism: Schizosaccharomyces pombe

uniprot P56818 44
type: UnificationXref
id: P56818
db: uniprot

Amyloid-beta A4 precursor protein-binding family B member 1
type: ProteinReference
xref: uniprot P46933 145
xref: PTHR14058:SF5
organism: Rattus norvegicus

Voltage-dependent L-type calcium channel subunit beta-1
type: ProteinReference
xref: uniprot Q8R3Z5 85
xref: PTHR11824:SF17
organism: Mus musculus

uniprot F1PP27 131
type: UnificationXref
id: F1PP27
db: uniprot

Protein kinase C-like 2
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P36583 549
organism: Schizosaccharomyces pombe

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot A8WRD7 244
organism: Caenorhabditis briggsae

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P36582 548
xref: PTHR24356:SF390
organism: Schizosaccharomyces pombe

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__C99-RIGHT__Abeta-_AICD-_r85
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

uniprot Q13936 78
type: UnificationXref
id: Q13936
db: uniprot

uniprot Q9CQR7 178
type: UnificationXref
id: Q9CQR7
db: uniprot

uniprot F7DVL1 519
type: UnificationXref
id: F7DVL1
db: uniprot

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: uniprot Q9NZ42 179
xref: PTHR16318:SF0
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MFK1 508
xref: PTHR24356:SF322
organism: Bos taurus

Serine/threonine-protein kinase N2
type: ProteinReference
xref: uniprot O08874 529
xref: PTHR24356:SF322
organism: Rattus norvegicus

uniprot Q944Q0 369
type: UnificationXref
id: Q944Q0
db: uniprot

uniprot H9FVB9 418
type: UnificationXref
id: H9FVB9
db: uniprot

PKN3 isoform 1
type: ProteinReference
xref: uniprot H2QXZ6 526
xref: PTHR24356:SF318
organism: Pan troglodytes

uniprot F7G632 409
type: UnificationXref
id: F7G632
db: uniprot

uniprot E2RGU7 504
type: UnificationXref
id: E2RGU7
db: uniprot

PTHR47965:SF69
type: RelationshipXref
id: PTHR47965:SF69
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3SR38 494
type: UnificationXref
id: A0A2I3SR38
db: uniprot

uniprot P09217 537
type: UnificationXref
id: P09217
db: uniprot

Gamma-secretase subunit APH-1B
type: ProteinReference
xref: uniprot Q8WW43 202
xref: PTHR12889:SF1
organism: Homo sapiens

PTHR24055:SF238
type: RelationshipXref
id: PTHR24055:SF238
db: PANTHER Family
relationship type: By Homology

uniprot Q05655 561
type: UnificationXref
id: Q05655
db: uniprot

ncbitaxon 7739 398
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot F7AWF2 213
type: UnificationXref
id: F7AWF2
db: uniprot

uniprot P34885 547
type: UnificationXref
id: P34885
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__APP-RIGHT__C99-_APPbeta-_r84
controller: BACE-1

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot Q6QI68 173
organism: Rattus norvegicus

TRUNCATION_LEFT__APP-RIGHT__C83-_APPalpha-_r48
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 681
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 680
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 679
left: APP
interaction type: TRUNCATION
right: C83
right: APPalpha

uniprot F6Q5F4 405
type: UnificationXref
id: F6Q5F4
db: uniprot

Kinesin light chain 3
type: ProteinReference
xref: PTHR45783:SF1
xref: uniprot Q6P597 474
organism: Homo sapiens

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 319
organism: Mus musculus

Furin
type: ProteinReference
xref: uniprot G7MVY8 413
xref: PTHR42884:SF1
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: uniprot F1MDC9 507
xref: PTHR24351:SF182
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63086 320
organism: Rattus norvegicus

PTHR10037:SF290
type: RelationshipXref
id: PTHR10037:SF290
db: PANTHER Family
relationship type: By Homology

uniprot G7MVY8 413
type: UnificationXref
id: G7MVY8
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot P53778 317
xref: PTHR24055:SF146
organism: Homo sapiens

uniprot Q61532 350
type: UnificationXref
id: Q61532
db: uniprot

uniprot Q9JIS7 88
type: UnificationXref
id: Q9JIS7
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot P53779 318
organism: Homo sapiens

uniprot A8WR64 500
type: UnificationXref
id: A8WR64
db: uniprot

Pro-BACE-1
type: ProteinReference
xref: P00081
standard name: Pro-beta-secretase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Pro-BACE-1Synonym: Asp-2,Aspartyl protease 2,MemapsinAccession: P00081
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Pro-BACE-1
member entity reference: Uncharacterized protein
member entity reference: Beta-secretase 1
member entity reference: Beta-secretase 2
member entity reference: BACE2 isoform 3

uniprot F1N5C5 98
type: UnificationXref
id: F1N5C5
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O23236 296
organism: Arabidopsis thaliana

Protein kinase C
type: ProteinReference
xref: uniprot F6XMN6 514
xref: PTHR24356:SF170
organism: Canis lupus familiaris

uniprot Q23316 222
type: UnificationXref
id: Q23316
db: uniprot

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: uniprot Q7PVR1 359
xref: PTHR24055:SF158
organism: Anopheles gambiae

uniprot P09215 535
type: UnificationXref
id: P09215
db: uniprot

uniprot Q9DGE2 375
type: UnificationXref
id: Q9DGE2
db: uniprot

uniprot Q9Z2A6 391
type: UnificationXref
id: Q9Z2A6
db: uniprot

uniprot E2RPJ2 254
type: UnificationXref
id: E2RPJ2
db: uniprot

PARTICIPANT STOICHIOMETRY r50 660
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 8.0

uniprot A0A2I3TBF6 127
type: UnificationXref
id: A0A2I3TBF6
db: uniprot

Presenilin homolog
type: ProteinReference
xref: uniprot O02194 154
xref: PTHR10202:SF13
organism: Drosophila melanogaster

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q1LWJ8 237
organism: Bos taurus

Presenilin N terminal fragment s24 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin N-terminal fragment
stoichiometric coefficient: 1.0

uniprot P08912 112
type: UnificationXref
id: P08912
db: uniprot

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa12 584
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__TACE-RIGHT__TACE-_r54
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 724
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 723
left: TACE
interaction type: STATE_TRANSITION
right: TACE

uniprot A0A2I3RQJ8 493
type: UnificationXref
id: A0A2I3RQJ8
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q05655 561
organism: Homo sapiens

IDA
type: EvidenceCodeVocabulary

PTHR12345:SF9
type: RelationshipXref
id: PTHR12345:SF9
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r50 659
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

ncbitaxon 367110 393
type: UnificationXref
id: 367110
db: ncbitaxon

Anterior pharynx defective 1 homolog A
type: ProteinReference
xref: PTHR12889:SF3
xref: uniprot Q5EB22 195
organism: Xenopus tropicalis

P00100
type: UnificationXref
id: P00100
db: PANTHER Pathway Component

P00102
type: UnificationXref
id: P00102
db: PANTHER Pathway Component

P00101
type: UnificationXref
id: P00101
db: PANTHER Pathway Component

uniprot Q866A2 32
type: UnificationXref
id: Q866A2
db: uniprot

ncbitaxon 9258 275
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot F1PU73 219
type: UnificationXref
id: F1PU73
db: uniprot

Presenilin C terminal fragment s42 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin C-terminal fragment
stoichiometric coefficient: 1.0

uniprot E2QWV4 144
type: UnificationXref
id: E2QWV4
db: uniprot

uniprot Q9Z1B7 390
type: UnificationXref
id: Q9Z1B7
db: uniprot

Presenilin enhancer 2 homolog
type: ProteinReference
xref: uniprot Q28GF7 171
xref: PTHR16318:SF0
organism: Xenopus tropicalis

uniprot Q61072 186
type: UnificationXref
id: Q61072
db: uniprot

uniprot E2RN88 454
type: UnificationXref
id: E2RN88
db: uniprot

uniprot F1MFK1 508
type: UnificationXref
id: F1MFK1
db: uniprot

L-type calcium channels
type: Protein
entity reference: L-type calcium channels
feature: ACTIVE 91
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase WNK8
type: ProteinReference
xref: uniprot Q944Q0 369
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 18
type: ProteinReference
xref: uniprot Q9C5C0 371
organism: Arabidopsis thaliana

Protein kinase C beta type
type: ProteinReference
xref: uniprot A8KBH6 499
xref: PTHR24356:SF158
organism: Xenopus tropicalis

uniprot P28841 427
type: UnificationXref
id: P28841
db: uniprot

uniprot F6YF14 147
type: UnificationXref
id: F6YF14
db: uniprot

uniprot P63239 433
type: UnificationXref
id: P63239
db: uniprot

Pen 2 s15 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pen-2
stoichiometric coefficient: 1.0

uniprot F6YCI6 132
type: UnificationXref
id: F6YCI6
db: uniprot

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24247:SF209
xref: uniprot A0A2J8JB58 93
organism: Pan troglodytes

PCSK2 isoform 2
type: ProteinReference
xref: uniprot H2QJZ8 415
organism: Pan troglodytes

Nicastrin
type: ProteinReference
xref: uniprot Q9VC27 226
xref: PTHR21092:SF0
organism: Drosophila melanogaster

Mitogen-activated protein kinase 4
type: ProteinReference
xref: PTHR24055:SF25
xref: uniprot E2RIY9 252
organism: Canis lupus familiaris

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q11179 326
xref: PTHR24055:SF79
organism: Caenorhabditis elegans

uniprot A0A3Q1MBH7 188
type: UnificationXref
id: A0A3Q1MBH7
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__C99_Fe65_-RIGHT__Complex__AICD_Fe65_-_Abeta-_r45
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

Kinesin Light Chain
type: ProteinReference
xref: PTHR45783:SF3
xref: uniprot H9G2T2 462
organism: Caenorhabditis elegans

uniprot F6TQT6 513
type: UnificationXref
id: F6TQT6
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7BYI4 517
xref: PTHR24356:SF158
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: uniprot Q7QCP8 573
xref: PTHR24356:SF240
organism: Anopheles gambiae

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase 20
type: ProteinReference
xref: PTHR24055:SF392
xref: uniprot Q9SJG9 385
organism: Arabidopsis thaliana

uniprot H2QA34 414
type: UnificationXref
id: H2QA34
db: uniprot

Kinesin light chain 3
type: ProteinReference
xref: uniprot E2RN88 454
xref: PTHR45783:SF1
organism: Canis lupus familiaris

Voltage-dependent L-type calcium channel subunit alpha-1S
type: ProteinReference
xref: uniprot Q02789 75
xref: PTHR45628:SF9
organism: Mus musculus

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 247

uniprot Q6RKB0 82
type: UnificationXref
id: Q6RKB0
db: uniprot

uniprot F7BYI4 517
type: UnificationXref
id: F7BYI4
db: uniprot

uniprot A1Z7T0 498
type: UnificationXref
id: A1Z7T0
db: uniprot

uniprot P68404 553
type: UnificationXref
id: P68404
db: uniprot

uniprot Q17446 331
type: UnificationXref
id: Q17446
db: uniprot

PARTICIPANT STOICHIOMETRY r58 711
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

uniprot O35431 136
type: UnificationXref
id: O35431
db: uniprot

uniprot O35598 486
type: UnificationXref
id: O35598
db: uniprot

ncbitaxon 10090 22
type: UnificationXref
id: 10090
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r58 713
type: Stoichiometry
physical entity: Complex (alpha7 nicotinic acetylcholine receptor/Abeta)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 712
type: Stoichiometry
physical entity: alpha7 nicotinic acetylcholine receptor
stoichiometric coefficient: 1.0

uniprot P24723 544
type: UnificationXref
id: P24723
db: uniprot

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q9WUI1 388
organism: Mus musculus

uniprot F1P630 257
type: UnificationXref
id: F1P630
db: uniprot

uniprot H2QLB4 288
type: UnificationXref
id: H2QLB4
db: uniprot

uniprot P56817 43
type: UnificationXref
id: P56817
db: uniprot

uniprot P08485 110
type: UnificationXref
id: P08485
db: uniprot

uniprot F1PGZ2 101
type: UnificationXref
id: F1PGZ2
db: uniprot

Mitogen-activated protein kinase p38a
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot O62618 299
organism: Drosophila melanogaster

Furin
type: ProteinReference
xref: uniprot P09958 420
xref: PTHR42884:SF1
organism: Homo sapiens

uniprot Q5PQM2 473
type: UnificationXref
id: Q5PQM2
db: uniprot

Complex (alpha7 nicotinic acetylcholine receptor/Abeta)
type: Complex
component stoichiometry: alpha7 nicotinic acetylcholine receptor s18 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: Abeta s19 sa15 STOICHIOMETRY ID COMPLEX
component: alpha7 nicotinic acetylcholine receptor
component: Abeta
feature: COMPLEX BINDING FEATURE s191 a235 625
feature: COMPLEX BINDING FEATURE s191 a235 627
cellular location: cytosol

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q7ZVK8 360
xref: PTHR24055:SF393
organism: Danio rerio

uniprot P05129 532
type: UnificationXref
id: P05129
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 302

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 30

PTHR11824:SF17
type: RelationshipXref
id: PTHR11824:SF17
db: PANTHER Family
relationship type: By Homology

Proprotein convertase subtilisin/kexin type 4
type: ProteinReference
xref: uniprot Q78EH2 441
organism: Rattus norvegicus

uniprot F7EH19 280
type: UnificationXref
id: F7EH19
db: uniprot

uniprot Q2TBQ9 472
type: UnificationXref
id: Q2TBQ9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H2Q930 15
organism: Pan troglodytes

uniprot F1P4Y5 9
type: UnificationXref
id: F1P4Y5
db: uniprot

Mitogen-activated protein kinase KSS1
type: ProteinReference
xref: uniprot P14681 301
organism: Saccharomyces cerevisiae

Voltage-dependent L-type calcium channel subunit beta-2
type: ProteinReference
xref: PTHR11824:SF9
xref: uniprot Q8CC27 83
organism: Mus musculus

KLC4 isoform 12
type: ProteinReference
xref: uniprot A0A2J8P024 448
xref: PTHR45783:SF6
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 231
xref: PTHR24055:SF162
organism: Gallus gallus

uniprot P70268 554
type: UnificationXref
id: P70268
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8X1S0 245
xref: PTHR24055:SF341
organism: Caenorhabditis briggsae

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 358

Fe65 s7 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 354
organism: Danio rerio

PTHR14058:SF5
type: RelationshipXref
id: PTHR14058:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q9LQQ9 380
type: UnificationXref
id: Q9LQQ9
db: uniprot

Putative gamma-secretase subunit APH-1C
type: ProteinReference
xref: PTHR12889:SF1
xref: uniprot Q9DCZ9 203
organism: Mus musculus

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24247:SF183
xref: uniprot A0A1D5Q9F8 92
organism: Macaca mulatta

Muscarinic acetylcholine receptor M5
type: ProteinReference
xref: PTHR24247:SF209
xref: uniprot Q920H4 122
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1P630 257
xref: PTHR24055:SF172
organism: Canis lupus familiaris

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P23298 542
organism: Mus musculus

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 148

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9LQQ9 380
organism: Arabidopsis thaliana

TRIGGER
type: RelationshipTypeVocabulary

uniprot A0A1D5Q5Z6 232
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

uniprot Q5TZF1 80
type: UnificationXref
id: Q5TZF1
db: uniprot

uniprot P09958 420
type: UnificationXref
id: P09958
db: uniprot

Proprotein convertase subtilisin/kexin type 4
type: ProteinReference
xref: uniprot Q6UW60 440
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot H2R0G7 290
organism: Pan troglodytes

ncbitaxon 36329 358
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot A0A3Q1MLH9 128
type: UnificationXref
id: A0A3Q1MLH9
db: uniprot

Calcium voltage-gated channel auxiliary subunit beta 2
type: ProteinReference
xref: PTHR11824:SF9
xref: uniprot E2RCN6 57
organism: Canis lupus familiaris

Abeta
type: Protein
entity reference: Abeta
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot E2QVF3 250
type: UnificationXref
id: E2QVF3
db: uniprot

uniprot Q0PY50 194
type: UnificationXref
id: Q0PY50
db: uniprot

Muscarinic acetylcholine receptor M1
type: ProteinReference
xref: uniprot P11229 114
xref: PTHR24247:SF182
organism: Homo sapiens

Complex (AICD/Fe65/ Tip60)
type: Complex
component stoichiometry: Tip60 s8 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fe65 s7 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: AICD s6 sa11 STOICHIOMETRY ID COMPLEX
component: Fe65
component: AICD
component: Tip60
feature: COMPLEX BINDING FEATURE s180 a219 585
feature: COMPLEX BINDING FEATURE s180 a219 583
feature: COMPLEX BINDING FEATURE s180 a219 581
cellular location: nucleus

uniprot A0A0D1C4Y4 228
type: UnificationXref
id: A0A0D1C4Y4
db: uniprot

kinesin
type: Protein
entity reference: kinesin
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa19 630
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein kinase C
type: ProteinReference
xref: uniprot E1BMG4 501
xref: PTHR24356:SF181
organism: Bos taurus

Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
type: Complex
component stoichiometry: Presenilin N terminal fragment s16 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: Nicastrin s13 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pen 2 s15 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: Aph 1 s14 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: Presenilin C terminal fragment s17 sa32 STOICHIOMETRY ID COMPLEX
component: Presenilin C-terminal fragment
component: Aph-1
component: Nicastrin
component: Presenilin N-terminal fragment
component: Pen-2
feature: COMPLEX BINDING FEATURE s253 a311 599
feature: COMPLEX BINDING FEATURE s253 a311 597
feature: ACTIVE 91
feature: COMPLEX BINDING FEATURE s253 a311 603
feature: COMPLEX BINDING FEATURE s253 a311 595
feature: COMPLEX BINDING FEATURE s253 a311 601
cellular location: cytosol

Histone acetyltransferase
type: ProteinReference
xref: PTHR10615:SF183
xref: uniprot K7BDV3 214
organism: Pan troglodytes

Pen 2 s23 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pen-2
stoichiometric coefficient: 1.0

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P24723 544
organism: Homo sapiens

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot Q8MQA1 84
organism: Caenorhabditis elegans

uniprot Q7Q042 572
type: UnificationXref
id: Q7Q042
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P49186 315
xref: PTHR24055:SF172
organism: Rattus norvegicus

uniprot E1B867 205
type: UnificationXref
id: E1B867
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6TKL3 264
organism: Xenopus tropicalis

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P49187 316
xref: PTHR24055:SF162
organism: Rattus norvegicus

Muscarinic acetylcholine receptor
type: ProteinReference
xref: PTHR24247:SF183
xref: uniprot F1PGZ2 101
organism: Canis lupus familiaris

Furin
type: Protein
entity reference: Furin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BACE-1 pro-domain
type: Protein
entity reference: BACE-1 pro-domain
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

uniprot Q39026 338
type: UnificationXref
id: Q39026
db: uniprot

uniprot O17798 419
type: UnificationXref
id: O17798
db: uniprot

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF2
xref: uniprot F6XU71 62
organism: Canis lupus familiaris

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9LV37 382
organism: Arabidopsis thaliana

uniprot F1MTK5 58
type: UnificationXref
id: F1MTK5
db: uniprot

Abeta
type: Protein
entity reference: Abeta
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

uniprot F6QEN9 481
type: UnificationXref
id: F6QEN9
db: uniprot

ncbitaxon 227321 247
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q90XF2 575
type: UnificationXref
id: Q90XF2
db: uniprot

uniprot E2R5H5 189
type: UnificationXref
id: E2R5H5
db: uniprot

uniprot P46822 466
type: UnificationXref
id: P46822
db: uniprot

Muscarinic acetylcholine receptor
type: ProteinReference
xref: uniprot H2Q3X5 105
xref: PTHR24247:SF182
organism: Pan troglodytes

uniprot P51559 432
type: UnificationXref
id: P51559
db: uniprot

uniprot P12657 115
type: UnificationXref
id: P12657
db: uniprot

uniprot F6Y4G8 270
type: UnificationXref
id: F6Y4G8
db: uniprot

Cholesterol
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot A0A2I3SDD9 50
xref: PTHR45628:SF9
organism: Pan troglodytes

PTHR24356:SF240
type: RelationshipXref
id: PTHR24356:SF240
db: PANTHER Family
relationship type: By Homology

uniprot A8X1H0 53
type: UnificationXref
id: A8X1H0
db: uniprot

Nicastrin
type: ProteinReference
xref: uniprot F1PU73 219
xref: PTHR21092:SF0
organism: Canis lupus familiaris

Bos taurus
type: BioSource
xref: ncbitaxon 9913 46

uniprot P36544 17
type: UnificationXref
id: P36544
db: uniprot

uniprot H2Q4U8 41
type: UnificationXref
id: H2Q4U8
db: uniprot

ncbitaxon 237561 346
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot Q9VBC7 444
type: UnificationXref
id: Q9VBC7
db: uniprot

uniprot Q07866 470
type: UnificationXref
id: Q07866
db: uniprot

Proprotein convertase subtilisin/kexin type 5
type: ProteinReference
xref: uniprot Q04592 434
organism: Mus musculus

Presenilin
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot H2Q8K1 152
organism: Pan troglodytes

uniprot Q11179 326
type: UnificationXref
id: Q11179
db: uniprot

uniprot A8XGC4 7
type: UnificationXref
id: A8XGC4
db: uniprot

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot F1MCT1 402
organism: Bos taurus

Voltage-dependent L-type calcium channel subunit alpha-1D
type: ProteinReference
xref: PTHR45628:SF11
xref: uniprot Q01668 72
organism: Homo sapiens

uniprot Q9XT97 168
type: UnificationXref
id: Q9XT97
db: uniprot

uniprot O14672 485
type: UnificationXref
id: O14672
db: uniprot

PTHR24356:SF246
type: RelationshipXref
id: PTHR24356:SF246
db: PANTHER Family
relationship type: By Homology

uniprot E2RAF0 452
type: UnificationXref
id: E2RAF0
db: uniprot

PTHR24356:SF210
type: RelationshipXref
id: PTHR24356:SF210
db: PANTHER Family
relationship type: By Homology

Muscarinic acetylcholine receptor M1
type: ProteinReference
xref: PTHR24247:SF182
xref: uniprot P08482 108
organism: Rattus norvegicus

uniprot P27732 71
type: UnificationXref
id: P27732
db: uniprot

Muscarinic acetylcholine receptor M3
type: ProteinReference
xref: PTHR24247:SF183
xref: uniprot P08483 109
organism: Rattus norvegicus

Muscarinic acetylcholine receptor M4
type: ProteinReference
xref: uniprot P08485 110
xref: PTHR24247:SF180
organism: Rattus norvegicus

TRANSPORT_LEFT__Complex__X11alpha_APP_-RIGHT__Complex__X11alpha_APP_-_r86
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 718
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 719
left: Complex (X11alpha/APP)
interaction type: TRANSPORT
right: Complex (X11alpha/APP)

L-type calcium channels
type: ProteinReference
xref: P00082
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.ION_CHANNEL.L-type_br_calcium_br_channels
comment: ENTITY_REFERENCE_NOTES=Long Name: L-type calcium channelsSynonym: Synonym not specifiedAccession: P00082
member entity reference: Uncharacterized protein
member entity reference: Voltage-dependent L-type calcium channel subunit alpha
member entity reference: Voltage-dependent L-type calcium channel subunit beta-2
member entity reference: Voltage-dependent L-type calcium channel subunit alpha-1D
member entity reference: Voltage-dependent L-type calcium channel subunit alpha-1C
member entity reference: Calcium voltage-gated channel auxiliary subunit beta 2
member entity reference: Voltage-dependent L-type calcium channel subunit alpha-1F
member entity reference: Voltage-dependent L-type calcium channel subunit alpha-1S
member entity reference: Voltage-dependent calcium channel type D subunit alpha-1
member entity reference: Voltage-dependent L-type calcium channel subunit beta-1
member entity reference: Voltage-dependent L-type calcium channel subunit alpha (Fragment)
member entity reference: Calcium voltage-gated channel auxiliary subunit beta 1
member entity reference: CACNB2 isoform 5

Voltage-dependent L-type calcium channel subunit alpha-1F
type: ProteinReference
xref: PTHR45628:SF2
xref: uniprot O60840 68
organism: Homo sapiens

PTHR24356:SF214
type: RelationshipXref
id: PTHR24356:SF214
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3SR38 494
xref: PTHR24356:SF181
organism: Pan troglodytes

BACE-1
type: Protein
entity reference: BACE-1
feature: ACTIVE 91
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

AICD
type: Protein
entity reference: AICD
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa11 582
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P63318 551
type: UnificationXref
id: P63318
db: uniprot

PARTICIPANT STOICHIOMETRY r87 714
type: Stoichiometry
physical entity: Complex (AICD/Fe65)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r87 715
type: Stoichiometry
physical entity: Complex (AICD/Fe65)
stoichiometric coefficient: 1.0

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__L_type_calcium_channels-RIGHT__L_type_calcium_channels-_re29
controller: Abeta

Extracellular signal-regulated kinase 2
type: ProteinReference
xref: uniprot Q54QB1 343
xref: PTHR24055:SF79
organism: Dictyostelium discoideum

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 10

uniprot P05771 534
type: UnificationXref
id: P05771
db: uniprot

uniprot Q05941 25
type: UnificationXref
id: Q05941
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q5PU49 567
xref: PTHR24356:SF365
organism: Canis lupus familiaris

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q9LM33 378
organism: Arabidopsis thaliana

uniprot P92208 323
type: UnificationXref
id: P92208
db: uniprot

alpha7 nicotinic acetylcholine receptor
type: Protein
entity reference: alpha7 nicotinic acetylcholine receptor
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot F7HT59 64
xref: PTHR45628:SF10
organism: Macaca mulatta

uniprot E2RKA7 253
type: UnificationXref
id: E2RKA7
db: uniprot

uniprot P21708 304
type: UnificationXref
id: P21708
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot K7CEN2 292
xref: PTHR24055:SF356
organism: Pan troglodytes

Disintegrin and metalloproteinase domain-containing protein 9
type: ProteinReference
xref: PTHR11905:SF136
xref: uniprot Q13443 185
organism: Homo sapiens

uniprot F1MFR6 403
type: UnificationXref
id: F1MFR6
db: uniprot

uniprot P24583 543
type: UnificationXref
id: P24583
db: uniprot

uniprot E1BQN6 502
type: UnificationXref
id: E1BQN6
db: uniprot

PARTICIPANT STOICHIOMETRY r56 716
type: Stoichiometry
physical entity: MAPK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 717
type: Stoichiometry
physical entity: MAPK
stoichiometric coefficient: 1.0

Endoprotease bli-4
type: ProteinReference
xref: uniprot P51559 432
organism: Caenorhabditis elegans

uniprot Q7QK68 442
type: UnificationXref
id: Q7QK68
db: uniprot

ncbitaxon 9031 10
type: UnificationXref
id: 9031
db: ncbitaxon

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r53
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 655
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 654
left: PKC
interaction type: STATE_TRANSITION
right: PKC

uniprot H2Q930 15
type: UnificationXref
id: H2Q930
db: uniprot

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q9C9U4 372
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r49 676
type: Stoichiometry
physical entity: C83
stoichiometric coefficient: 1.0

AGAP008094-PA
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot Q7Q3Y1 174
organism: Anopheles gambiae

ADAM10
type: Protein
entity reference: ADAM10
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E1BMG4 501
type: UnificationXref
id: E1BMG4
db: uniprot

Abeta
type: Complex
component stoichiometry: Abeta s173 a211 STOICHIOMETRY ID COMPLEX
component: Abeta

uniprot Q13164 327
type: UnificationXref
id: Q13164
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot E1BQN6 502
xref: PTHR24356:SF170
organism: Gallus gallus

uniprot P49582 21
type: UnificationXref
id: P49582
db: uniprot

APP
type: Protein
entity reference: APP
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa1 648
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6R8N9 262
xref: PTHR24055:SF79
organism: Macaca mulatta

Serine/threonine-protein kinase N2
type: ProteinReference
xref: uniprot Q8BWW9 574
xref: PTHR24356:SF322
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r49 678
type: Stoichiometry
physical entity: p3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 654
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r49 677
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 655
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot H2Q8F2 523
organism: Pan troglodytes

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa2 650
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 15
type: ProteinReference
xref: PTHR24055:SF79
xref: uniprot Q8TD08 365
organism: Homo sapiens

PKC
type: Protein
entity reference: PKC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r65 666
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r85 721
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r65 664
type: Stoichiometry
physical entity: C99
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r85 722
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r65 665
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r85 720
type: Stoichiometry
physical entity: C99
stoichiometric coefficient: 1.0

uniprot Q05090 468
type: UnificationXref
id: Q05090
db: uniprot

uniprot A0A1D5PV02 48
type: UnificationXref
id: A0A1D5PV02
db: uniprot

uniprot P49768 156
type: UnificationXref
id: P49768
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 325

uniprot Q13698 77
type: UnificationXref
id: Q13698
db: uniprot

uniprot Q62849 438
type: UnificationXref
id: Q62849
db: uniprot

Presenilin sel-12
type: ProteinReference
xref: uniprot P52166 159
xref: PTHR10202:SF13
organism: Caenorhabditis elegans

ncbitaxon 3702 201
type: UnificationXref
id: 3702
db: ncbitaxon

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P28867 545
organism: Mus musculus

uniprot A0A2J8JB58 93
type: UnificationXref
id: A0A2J8JB58
db: uniprot

uniprot A0A1D5QT06 126
type: UnificationXref
id: A0A1D5QT06
db: uniprot

PTHR12345:SF12
type: RelationshipXref
id: PTHR12345:SF12
db: PANTHER Family
relationship type: By Homology

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF11
xref: uniprot A0A2I3SHJ9 51
organism: Pan troglodytes

PTHR12345:SF14
type: RelationshipXref
id: PTHR12345:SF14
db: PANTHER Family
relationship type: By Homology

TRUNCATION_LEFT__C99-RIGHT__AICD-_Abeta-_r65
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 665
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 666
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 664
left: C99
interaction type: TRUNCATION
right: Abeta
right: AICD

uniprot Q15759 328
type: UnificationXref
id: Q15759
db: uniprot

Alpha8 subunit of nicotinic acetylcholine receptor
type: ProteinReference
xref: uniprot Q03481 24
organism: Gallus gallus

uniprot Q39021 334
type: UnificationXref
id: Q39021
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A2I3RZ31 234
xref: PTHR24055:SF162
organism: Pan troglodytes

uniprot Q8MXI4 363
type: UnificationXref
id: Q8MXI4
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7A632 515
xref: PTHR24356:SF158
organism: Monodelphis domestica

uniprot A0A2I3TWA0 218
type: UnificationXref
id: A0A2I3TWA0
db: uniprot

Muscarinic acetylcholine receptor
type: ProteinReference
xref: uniprot F1MCK3 97
xref: PTHR24247:SF209
organism: Bos taurus

uniprot A0A2I3SB38 142
type: UnificationXref
id: A0A2I3SB38
db: uniprot

Presenilin-1
type: ProteinReference
xref: uniprot Q6RH31 163
xref: PTHR10202:SF18
organism: Canis lupus familiaris

uniprot Q6P5Z2 571
type: UnificationXref
id: Q6P5Z2
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q91Y86 368
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__APP-RIGHT__C83-_APPalpha-_r48
controller: ADAM10

Voltage-dependent L-type calcium channel subunit alpha-1D
type: ProteinReference
xref: uniprot P27732 71
xref: PTHR45628:SF11
organism: Rattus norvegicus

alpha7 nicotinic acetylcholine receptor s18 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alpha7 nicotinic acetylcholine receptor
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9WTY9 387
organism: Rattus norvegicus

uniprot O61443 298
type: UnificationXref
id: O61443
db: uniprot

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 91
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Muscarinic acetylcholine receptor M4
type: ProteinReference
xref: uniprot P17200 116
xref: PTHR24248:SF142
organism: Gallus gallus

Presenilin
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot F7AGU8 150
organism: Macaca mulatta

kinesin
type: Protein
entity reference: kinesin
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa17 644
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

Presenilin N-terminal fragment
type: Protein
entity reference: Presenilin N-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa26 622
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

uniprot Q7PVR1 359
type: UnificationXref
id: Q7PVR1
db: uniprot

Neuroendocrine convertase 2
type: ProteinReference
xref: uniprot P28841 427
organism: Rattus norvegicus

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot P28840 426
organism: Rattus norvegicus

uniprot A8X994 450
type: UnificationXref
id: A8X994
db: uniprot

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

uniprot F7HBW2 63
type: UnificationXref
id: F7HBW2
db: uniprot

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

Neuroendocrine convertase 2
type: ProteinReference
xref: uniprot G5ECN9 412
organism: Caenorhabditis elegans

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot P27704 308
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot F7C2C6 276
organism: Monodelphis domestica

Furin
type: ProteinReference
xref: uniprot B0JYR0 396
xref: PTHR42884:SF1
organism: Bos taurus

uniprot E1BWA3 503
type: UnificationXref
id: E1BWA3
db: uniprot

uniprot P20444 541
type: UnificationXref
id: P20444
db: uniprot

uniprot Q02789 75
type: UnificationXref
id: Q02789
db: uniprot

APP
type: Protein
entity reference: APP
cellular location: vesicle
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 13616 14
type: UnificationXref
id: 13616
db: ncbitaxon

AICD
type: Protein
entity reference: AICD
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Pen 2 s37 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pen-2
stoichiometric coefficient: 1.0

uniprot P41985 120
type: UnificationXref
id: P41985
db: uniprot

uniprot P37285 465
type: UnificationXref
id: P37285
db: uniprot

uniprot P28482 309
type: UnificationXref
id: P28482
db: uniprot

uniprot E2RSB0 255
type: UnificationXref
id: E2RSB0
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 307

uniprot Q39027 339
type: UnificationXref
id: Q39027
db: uniprot

Histone acetyltransferase
type: ProteinReference
xref: PTHR10615:SF183
xref: uniprot A0A3Q1MIR9 211
organism: Bos taurus

uniprot Q9Y5Z0 47
type: UnificationXref
id: Q9Y5Z0
db: uniprot

PTHR10202:SF18
type: RelationshipXref
id: PTHR10202:SF18
db: PANTHER Family
relationship type: By Homology

PTHR10202:SF13
type: RelationshipXref
id: PTHR10202:SF13
db: PANTHER Family
relationship type: By Homology

uniprot P53778 317
type: UnificationXref
id: P53778
db: uniprot

ncbitaxon 559292 302
type: UnificationXref
id: 559292
db: ncbitaxon

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot O02812 293
organism: Canis lupus familiaris

uniprot H9EQI5 484
type: UnificationXref
id: H9EQI5
db: uniprot

Amyloid-beta A4 precursor protein-binding family A member 2
type: ProteinReference
xref: PTHR12345:SF12
xref: uniprot O35431 136
organism: Rattus norvegicus

Furin-like protease kpc-1
type: ProteinReference
xref: uniprot O17798 419
xref: PTHR42884:SF3
organism: Caenorhabditis elegans

Amyloid-beta A4 precursor protein-binding family A member 1
type: ProteinReference
xref: PTHR12345:SF14
xref: uniprot O35430 135
organism: Rattus norvegicus

Protein kinase C-like
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P87253 555
organism: Neurospora crassa

uniprot A0A2I3SSR3 395
type: UnificationXref
id: A0A2I3SSR3
db: uniprot

Neuronal acetylcholine receptor subunit alpha-7
type: ProteinReference
xref: uniprot P49582 21
xref: PTHR18945:SF832
organism: Mus musculus

Kinesin light chain 4
type: ProteinReference
xref: PTHR45783:SF6
xref: uniprot F1MWR7 455
organism: Bos taurus

ncbitaxon 665079 242
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot G5E577 285
type: UnificationXref
id: G5E577
db: uniprot

uniprot F1NMN4 99
type: UnificationXref
id: F1NMN4
db: uniprot

uniprot P08911 111
type: UnificationXref
id: P08911
db: uniprot

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: uniprot P22002 70
xref: PTHR45628:SF10
organism: Rattus norvegicus

PTHR10202:SF24
type: RelationshipXref
id: PTHR10202:SF24
db: PANTHER Family
relationship type: By Homology

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot F1PUS1 404
organism: Canis lupus familiaris

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot J9P0J9 170
organism: Canis lupus familiaris

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

Amyloid-beta A4 precursor protein-binding family A member 3
type: ProteinReference
xref: PTHR12345:SF9
xref: uniprot O88888 137
organism: Mus musculus

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 386
xref: PTHR24055:SF172
organism: Mus musculus

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF171
xref: uniprot Q61532 350
organism: Mus musculus

TRUNCATION_LEFT__Presenilin-RIGHT__Presenilin_N_terminal_fragment-_Presenilin_C_terminal_fragment-_r76
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 696
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 694
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 695
left: Presenilin
interaction type: TRUNCATION
right: Presenilin C-terminal fragment
right: Presenilin N-terminal fragment

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 469

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9N272 384
xref: PTHR24055:SF107
organism: Pan troglodytes

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

uniprot Q9DBS5 477
type: UnificationXref
id: Q9DBS5
db: uniprot

uniprot Q99MK2 217
type: UnificationXref
id: Q99MK2
db: uniprot

PTHR45628:SF9
type: RelationshipXref
id: PTHR45628:SF9
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q84UI5 362
organism: Oryza sativa

APPalpha
type: Protein
entity reference: APPalpha
comment: SPECIES_TYPE=PROTEIN

Amyloid-beta A4 precursor protein-binding family A member 1
type: ProteinReference
xref: uniprot Q02410 140
xref: PTHR12345:SF14
organism: Homo sapiens

PTHR45628:SF2
type: RelationshipXref
id: PTHR45628:SF2
db: PANTHER Family
relationship type: By Homology

uniprot F6ZTS0 273
type: UnificationXref
id: F6ZTS0
db: uniprot

Muscarinic acetylcholine receptor M3
type: ProteinReference
xref: PTHR24247:SF183
xref: uniprot P20309 117
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TXC2 265
xref: PTHR24055:SF107
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__APP_kinesin__Microtubule_-RIGHT__APPbeta-_Complex__kinesin_Microtubule_-_C99-_r64
controller: BACE-1

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot V5IKE7 392
xref: PTHR24055:SF158
organism: Neurospora crassa

uniprot F1PUS1 404
type: UnificationXref
id: F1PUS1
db: uniprot

uniprot A8X1S0 245
type: UnificationXref
id: A8X1S0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6REU0 60
xref: PTHR11824:SF9
organism: Monodelphis domestica

Presenilin C-terminal fragment
type: Protein
entity reference: Presenilin C-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa32 604
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1PFZ9 206
type: UnificationXref
id: F1PFZ9
db: uniprot

uniprot P32211 119
type: UnificationXref
id: P32211
db: uniprot

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

uniprot F7B5L8 274
type: UnificationXref
id: F7B5L8
db: uniprot

PANTHER Pathway P00003 1
type: UnificationXref
id: P00003
db: PANTHER Pathway

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot A0A3Q1LTT9 236
organism: Bos taurus

uniprot Q99246 87
type: UnificationXref
id: Q99246
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5QUZ8 233
xref: PTHR24055:SF203
organism: Macaca mulatta

uniprot F1MDC9 507
type: UnificationXref
id: F1MDC9
db: uniprot

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

Complex (C99/Fe65)
type: Complex
component stoichiometry: Fe65 s2 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: C99 s1 sa3 STOICHIOMETRY ID COMPLEX
component: Fe65
component: C99
feature: COMPLEX BINDING FEATURE s156 a188 579
feature: COMPLEX BINDING FEATURE s156 a188 577
cellular location: cytosol

PTHR24055:SF154
type: RelationshipXref
id: PTHR24055:SF154
db: PANTHER Family
relationship type: By Homology

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q9WTQ0 576
organism: Rattus norvegicus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 344

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: uniprot P26016 425
xref: PTHR42884:SF3
organism: Drosophila melanogaster

Kinesin light chain 2 isoform 1
type: ProteinReference
xref: uniprot F6YHS7 458
xref: PTHR45783:SF2
organism: Macaca mulatta

uniprot P16054 539
type: UnificationXref
id: P16054
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QXA9 511
xref: PTHR24356:SF318
organism: Macaca mulatta

ADAM metallopeptidase domain 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot F1PFZ9 206
organism: Canis lupus familiaris

PTHR16318:SF0
type: RelationshipXref
id: PTHR16318:SF0
db: PANTHER Family
relationship type: By Homology

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 333

uniprot A1A4I4 497
type: UnificationXref
id: A1A4I4
db: uniprot

Pen-2
type: Protein
entity reference: Pen-2
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Disintegrin and metalloproteinase domain-containing protein 9
type: ProteinReference
xref: PTHR11905:SF136
xref: uniprot Q61072 186
organism: Mus musculus

PTHR24055:SF189
type: RelationshipXref
id: PTHR24055:SF189
db: PANTHER Family
relationship type: By Homology

Voltage-dependent L-type calcium channel subunit alpha-1C
type: ProteinReference
xref: PTHR45628:SF10
xref: uniprot Q13936 78
organism: Homo sapiens

uniprot O42376 297
type: UnificationXref
id: O42376
db: uniprot

uniprot H9G2T2 462
type: UnificationXref
id: H9G2T2
db: uniprot

Furin
type: ProteinReference
xref: uniprot P23188 423
xref: PTHR42884:SF1
organism: Mus musculus

uniprot Q10N20 324
type: UnificationXref
id: Q10N20
db: uniprot

uniprot Q6P597 474
type: UnificationXref
id: Q6P597
db: uniprot

Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
type: Complex
component stoichiometry: Presenilin N terminal fragment s38 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: Presenilin C terminal fragment s42 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: Aph 1 s36 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pen 2 s37 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: Nicastrin s35 sa23 STOICHIOMETRY ID COMPLEX
component: Nicastrin
component: Pen-2
component: Presenilin C-terminal fragment
component: Presenilin N-terminal fragment
component: Aph-1
feature: COMPLEX BINDING FEATURE s260 a310 619
feature: COMPLEX BINDING FEATURE s260 a310 617
feature: ACTIVE 91
feature: COMPLEX BINDING FEATURE s260 a310 623
feature: COMPLEX BINDING FEATURE s260 a310 621
feature: COMPLEX BINDING FEATURE s260 a310 615
cellular location: Golgi apparatus

uniprot Q54QB1 343
type: UnificationXref
id: Q54QB1
db: uniprot

uniprot P97887 160
type: UnificationXref
id: P97887
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: uniprot Q05513 560
xref: PTHR24356:SF170
organism: Homo sapiens

uniprot Q5EB22 195
type: UnificationXref
id: Q5EB22
db: uniprot

Protein kinase N3
type: ProteinReference
xref: uniprot A0A3Q1LM61 495
xref: PTHR24356:SF318
organism: Bos taurus

uniprot Q6RH31 163
type: UnificationXref
id: Q6RH31
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QLB4 288
xref: PTHR24055:SF203
organism: Pan troglodytes

uniprot P05067 36
type: UnificationXref
id: P05067
db: uniprot

Serine/threonine-protein kinase N2
type: ProteinReference
xref: uniprot Q16513 564
xref: PTHR24356:SF322
organism: Homo sapiens

Tip60 s8 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tip60
stoichiometric coefficient: 1.0

uniprot P98084 139
type: UnificationXref
id: P98084
db: uniprot

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

Gamma-secretase subunit APH1-like
type: ProteinReference
xref: PTHR12889:SF0
xref: uniprot Q8L9G7 200
organism: Arabidopsis thaliana

uniprot H2QS62 289
type: UnificationXref
id: H2QS62
db: uniprot

PTHR24055:SF171
type: RelationshipXref
id: PTHR24055:SF171
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase N1
type: ProteinReference
xref: uniprot Q16512 563
xref: PTHR24356:SF246
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BZF6 54
xref: PTHR11824:SF9
organism: Gallus gallus

AGAP012252-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q042 572
xref: PTHR24356:SF390
organism: Anopheles gambiae

uniprot P14681 301
type: UnificationXref
id: P14681
db: uniprot

APP s34 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

uniprot G5ECN9 412
type: UnificationXref
id: G5ECN9
db: uniprot

uniprot Q9WUI1 388
type: UnificationXref
id: Q9WUI1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot A0A1D5Q5Z6 232
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RKL5 394
organism: Macaca mulatta

ncbitaxon 7227 30
type: UnificationXref
id: 7227
db: ncbitaxon

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P17252 540
xref: PTHR24356:SF193
organism: Homo sapiens

uniprot O88777 155
type: UnificationXref
id: O88777
db: uniprot

Abeta s19 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

uniprot P47811 314
type: UnificationXref
id: P47811
db: uniprot

Neuronal acetylcholine receptor subunit alpha-7
type: ProteinReference
xref: uniprot F1P4Y5 9
xref: PTHR18945:SF832
organism: Gallus gallus

Voltage-dependent L-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR45628:SF9
xref: uniprot Q6RKB0 82
organism: Danio rerio

MAPK
type: ProteinReference
xref: P00099
standard name: Mitogen activated protein kinase
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.MAPK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen activated protein kinaseSynonym: ERKAccession: P00099
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase 18
member entity reference: Mitogen-activated protein kinase 7
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase 15
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase 4
member entity reference: Mitogen-activated protein kinase pmk-1
member entity reference: Mitogen-activated protein kinase FUS3
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase 20
member entity reference: Mitogen-activated protein kinase p38a
member entity reference: Serine/threonine-protein kinase WNK2
member entity reference: Mitogen-activated protein kinase 19
member entity reference: Stress-activated protein kinase JNK
member entity reference: Mitogen-activated protein kinase p38b

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q16539 329
organism: Homo sapiens

APBA1 isoform 1
type: ProteinReference
xref: uniprot H2QXC2 134
xref: PTHR12345:SF14
organism: Pan troglodytes

uniprot H9EU39 527
type: UnificationXref
id: H9EU39
db: uniprot

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: uniprot Q5A1D3 345
xref: PTHR24055:SF158
organism: Candida albicans

Voltage-dependent calcium channel type D subunit alpha-1
type: ProteinReference
xref: uniprot Q24270 79
organism: Drosophila melanogaster

Kinesin light chain 4
type: ProteinReference
xref: uniprot E2RCD4 453
xref: PTHR45783:SF6
organism: Canis lupus familiaris

uniprot P63085 319
type: UnificationXref
id: P63085
db: uniprot

Proprotein convertase subtilisin/kexin type 7
type: ProteinReference
xref: uniprot Q16549 436
organism: Homo sapiens

Trans Golgi network protease furin
type: ProteinReference
xref: uniprot Q91000 443
xref: PTHR42884:SF1
organism: Gallus gallus

Kinesin light chain 2
type: ProteinReference
xref: uniprot Q08DH4 471
xref: PTHR45783:SF2
organism: Bos taurus

Muscarinic acetylcholine receptor
type: ProteinReference
xref: uniprot A0A2J8M701 94
xref: PTHR24248:SF153
organism: Pan troglodytes

Presenilin-2
type: ProteinReference
xref: uniprot Q90X07 164
xref: PTHR10202:SF24
organism: Gallus gallus

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 261

Histone acetyltransferase
type: ProteinReference
xref: PTHR10615:SF183
xref: uniprot E2RE71 212
organism: Canis lupus familiaris

uniprot P21661 422
type: UnificationXref
id: P21661
db: uniprot

Disintegrin and metalloproteinase domain-containing protein 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot Q9Z0F8 209
organism: Mus musculus

uniprot Q95NE7 370
type: UnificationXref
id: Q95NE7
db: uniprot

uniprot E2RCN6 57
type: UnificationXref
id: E2RCN6
db: uniprot

uniprot Q9DGD9 373
type: UnificationXref
id: Q9DGD9
db: uniprot

uniprot E2RSE6 401
type: UnificationXref
id: E2RSE6
db: uniprot

uniprot P22002 70
type: UnificationXref
id: P22002
db: uniprot

uniprot P79996 322
type: UnificationXref
id: P79996
db: uniprot

uniprot F7CQE8 40
type: UnificationXref
id: F7CQE8
db: uniprot

uniprot F6YHS7 458
type: UnificationXref
id: F6YHS7
db: uniprot

KLC3 isoform 7
type: ProteinReference
xref: PTHR45783:SF1
xref: uniprot A0A2I3TLB5 447
organism: Pan troglodytes

uniprot H2Q9I4 483
type: UnificationXref
id: H2Q9I4
db: uniprot