ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.BACE-1_br_pro-domain
ENTITY_REFERENCE_NOTES=Long Name: BACE-1 pro-domainSynonym: Synonym not specifiedAccession: P00094
Voltage-dependent L-type calcium channel subunit alpha
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.APP
ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor proteinSynonym: Synonym not specifiedAccession: P00085
Amyloid beta precursor protein binding family A member 2
Voltage-dependent L-type calcium channel subunit alpha (Fragment)
Proprotein convertase subtilisin/kexin type 2
Disintegrin and metalloproteinase domain-containing protein 17
Muscarinic acetylcholine receptor M2 (Fragment)
Neuronal acetylcholine receptor subunit alpha-7
ENTITY_REFERENCE_NOTES=Long Name: PresenilinSynonym: sel-12Accession: P00098
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Presenilin
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.p3
ENTITY_REFERENCE_NOTES=Long Name: p3Synonym: Synonym not specifiedAccession: P00086
Amyloid-beta A4 precursor protein-binding family A member 2
Neuroendocrine convertase 2 isoform 1 preproprotein
Proprotein convertase subtilisin/kexin type 6
Gamma-secretase subunit APH-1B isoform 1
ENTITY_REFERENCE_NOTES=Long Name: HIV-1 Tat interactive protein, 60kDaSynonym: HTATIP1,PLIP,TIP,TIP60,cPLA2Accession: P00093
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Tip60
Amyloid precursor binding protein, family B
ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor binding protein, family BSynonym: RirAccession: P00087
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Fe65
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.A_beta_
ENTITY_REFERENCE_NOTES=Long Name: Beta-amyloidSynonym: Abeta1-40,Abeta1-42Accession: P00096
Amyloid-beta A4 precursor protein-binding family A member 1
ENTITY_REFERENCE_NOTES=Long Name: Anterior pharynx defective-1Synonym: Synonym not specifiedAccession: P00091
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Aph-1
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.kinesin
Amyloid precursor protein beta-ectodomain
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.APP_beta_
ENTITY_REFERENCE_NOTES=Long Name: Amino terminal fragment of amyloid precursor proteinSynonym: Synonym not specifiedAccession: P00104
ENTITY_REFERENCE_NOTES=Long Name: Presenilin enhancer 2Synonym: Synonym not specifiedAccession: P00089
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Pen-2
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.PKC
ENTITY_REFERENCE_NOTES=Long Name: Protein kinase CSynonym: Synonym not specifiedAccession: P00109
Carboxy-terminal 99 amino acids of amyloid precursor protein
ENTITY_REFERENCE_NOTES=Long Name: Carboxy-terminal 99 amino acids of amyloid precursor proteinSynonym: Synonym not specifiedAccession: P00106
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.C99
ENTITY_REFERENCE_NOTES=Long Name: meltrin gammaSynonym: ADAM9Accession: P00090
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.MDC9
Nicotinic acetylcholine receptor alpha5, isoform B
Voltage-dependent L-type calcium channel subunit alpha-1F
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Nicastrin
ENTITY_REFERENCE_NOTES=Long Name: NicastrinSynonym: Synonym not specifiedAccession: P00095
Aph-1 homolog A, gamma-secretase subunit
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Furin
ENTITY_REFERENCE_NOTES=Long Name: FurinSynonym: Synonym not specifiedAccession: P00105
Amyloid beta precursor protein binding family B member 1
Disintegrin and metalloproteinase domain-containing protein 10
Voltage-dependent L-type calcium channel subunit alpha-1C
Voltage-dependent L-type calcium channel subunit alpha-1D
Amyloid-beta A4 precursor protein-binding family A member 3
Voltage-dependent L-type calcium channel subunit beta-1
Voltage-dependent L-type calcium channel subunit beta-2
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.Presenilin_br_C-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Presenilin C-terminal fragmentSynonym: Synonym not specifiedAccession: P00102
Voltage-dependent L-type calcium channel subunit alpha-1S
Proprotein convertase subtilisin/kexin type 7
Nicotinic acetylcholine receptor alpha6, isoform E
Proprotein convertase subtilisin/kexin type 4
ENTITY_REFERENCE_NOTES=Long Name: TNF-alpha converting enzymeSynonym: ADAM17,alpha-secretaseAccession: P00092
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.TACE
Proprotein convertase subtilisin/kexin type 1
Beta-site amyloid precursor protein-cleaving enzyme
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.BACE-1
ENTITY_REFERENCE_NOTES=Long Name: Beta-site amyloid precursor protein-cleaving enzymeSynonym: Asp2,asp-2,beta-secretase,memapsin,memapsin-2Accession: P00101
Furin, paired basic amino acid cleaving enzyme
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.Presenilin_br_N-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Presenilin N-terminal fragmentSynonym: Synonym not specifiedAccession: P00088
Amyloid precursor protein intracellular domain
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.AICD
ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor protein intracellular domainSynonym: Synonym not specifiedAccession: P00080
Amyloid beta precursor protein binding family A member 1
Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.ADAM10
ENTITY_REFERENCE_NOTES=Long Name: A disintegrase and metalloprotease 10Synonym: Synonym not specifiedAccession: P00108
ENTITY_REFERENCE_NOTES=Long Name: alpha7 nicotinic acetylcholine receptorSynonym: Synonym not specifiedAccession: P00079
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.RECEPTOR._alpha_7 nicotinic_br_acetylcholine_br_receptor
Alzheimer disease-amyloid secretase pathway
MODEL_NOTES=Panther Pathway: P00003The amyloid precursor protein can be cleaved by multiple enzymes. Sequential cleavage by alpha-secretase (TACE, ADAM10 or MDC9) followed by gamma-secretase (presenilin complex) results in the formation of benign p3. By contrast, cleavage by beta-secretase (BACE) followed by gamma-secretase cleavage produces amyloid-beta, a fragment which assembles into senile plaques in Alzheimer's disease patients' brains. Medline=10806097Medline=11484003Medline=11520976Medline=12142279Medline=14598312PMID: 10806097PMID: 11484003PMID: 11520976PMID: 12142279PMID: 14598312
Amyloid beta A4 precursor protein-binding family A
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.X11_alpha_
ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor binding protein, family ASynonym: D9S411E,MINT1Accession: P00084
Amyloid precursor protein alpha ectodomain
ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor protein alpha ectodomainSynonym: Synonym not specifiedAccession: P00097
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.APP_alpha_
Calcium voltage-gated channel auxiliary subunit beta 1
Carboxy-terminal 83 amino acids of amyloid precursor protein
ENTITY_REFERENCE_NOTES=Long Name: Carboxy-terminal 83 amino acids of amyloid precursor proteinSynonym: Synonym not specifiedAccession: P00100
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.TRUNCATED.C83
Acetylcholine receptor subunit alpha-type acr-16
Amyloid-beta A4 precursor protein-binding family B member 1
ENTITY_REFERENCE_NOTES=Long Name: Muscarinic acetylcholine receptorsSynonym: Synonym not specifiedAccession: P00083
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.RECEPTOR.Muscarinic_br_acetylcholine_br_receptors
Neuroendocrine convertase 1 isoform 1 preproprotein
Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
ENTITY_REFERENCE_NOTES=Long Name: Pro-BACE-1Synonym: Asp-2,Aspartyl protease 2,MemapsinAccession: P00081
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.Pro-BACE-1
Mitogen-activated protein kinase (Fragment)
Complex (alpha7 nicotinic acetylcholine receptor/Abeta)
Calcium voltage-gated channel auxiliary subunit beta 2
Proprotein convertase subtilisin/kexin type 5
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.ION_CHANNEL.L-type_br_calcium_br_channels
ENTITY_REFERENCE_NOTES=Long Name: L-type calcium channelsSynonym: Synonym not specifiedAccession: P00082
Disintegrin and metalloproteinase domain-containing protein 9
Alpha8 subunit of nicotinic acetylcholine receptor
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-amyloid secretase pathway.PROTEIN.GENERIC.MAPK
ENTITY_REFERENCE_NOTES=Long Name: Mitogen activated protein kinaseSynonym: ERKAccession: P00099
Voltage-dependent calcium channel type D subunit alpha-1