PTHR11937:SF411
type: RelationshipXref
id: PTHR11937:SF411
db: PANTHER Family
relationship type: By Homology

APP
type: Protein
entity reference: APP
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6SRK5 940
type: UnificationXref
id: F6SRK5
db: uniprot

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot F1P476 175
organism: Gallus gallus

PTHR11937:SF414
type: RelationshipXref
id: PTHR11937:SF414
db: PANTHER Family
relationship type: By Homology

Matrix metalloproteinase-21
type: ProteinReference
xref: uniprot Q8K3F2 651
xref: PTHR10201:SF147
organism: Mus musculus

eco ECO:0000303 1014
type: UnificationXref
id: ECO:0000303
db: eco

Matrix metallopeptidase 27
type: ProteinReference
xref: PTHR10201:SF115
xref: uniprot F1NZ61 580
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__E_cadherin_beta_catenin__gammacatenin_alphacatenin__actin_-RIGHT__E_cadherin_C_terminal_fragment-_E_cadherin_N_terminal_fragment-_r28
controller: Matrix metalloprotease

uniprot F1NZ61 580
type: UnificationXref
id: F1NZ61
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

uniprot Q13467 406
type: UnificationXref
id: Q13467
db: uniprot

Frizzled class receptor 4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot F6V5F4 380
organism: Xenopus tropicalis

PTHR11937:SF409
type: RelationshipXref
id: PTHR11937:SF409
db: PANTHER Family
relationship type: By Homology

TRP (Transient receptor potential) channel family
type: ProteinReference
xref: PTHR10117:SF54
xref: uniprot Q8I6Y9 502
organism: Caenorhabditis elegans

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot Q28IC7 858
organism: Xenopus tropicalis

uniprot P53501 243
type: UnificationXref
id: P53501
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Gene transcription
controller: Nectin 1alpha intracellular fragment

uniprot F6SCP4 185
type: UnificationXref
id: F6SCP4
db: uniprot

uniprot D3ZXD9 571
type: UnificationXref
id: D3ZXD9
db: uniprot

uniprot Q9R0S3 727
type: UnificationXref
id: Q9R0S3
db: uniprot

uniprot Q9NL43 1072
type: UnificationXref
id: Q9NL43
db: uniprot

Frizzled-2
type: ProteinReference
xref: uniprot Q08464 405
xref: PTHR11309:SF34
organism: Rattus norvegicus

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot Q08463 404
organism: Rattus norvegicus

ncbitaxon 10228 138
type: UnificationXref
id: 10228
db: ncbitaxon

uniprot Q14332 407
type: UnificationXref
id: Q14332
db: uniprot

uniprot P29120 984
type: UnificationXref
id: P29120
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F7EV26 793
xref: PTHR12027:SF7
organism: Macaca mulatta

uniprot A0A3Q1MDX6 357
type: UnificationXref
id: A0A3Q1MDX6
db: uniprot

uniprot Q9Z0F8 918
type: UnificationXref
id: Q9Z0F8
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 33

uniprot Q810T5 720
type: UnificationXref
id: Q810T5
db: uniprot

uniprot F1MDE1 51
type: UnificationXref
id: F1MDE1
db: uniprot

Notch extracellular fragment
type: Protein
entity reference: Notch extracellular fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa4 1082
comment: SPECIES_TYPE=PROTEIN

uniprot P56706 855
type: UnificationXref
id: P56706
db: uniprot

uniprot F7C949 540
type: UnificationXref
id: F7C949
db: uniprot

uniprot A8Y4Q9 125
type: UnificationXref
id: A8Y4Q9
db: uniprot

PTHR24044:SF415
type: RelationshipXref
id: PTHR24044:SF415
db: PANTHER Family
relationship type: By Homology

uniprot F6PMQ6 777
type: UnificationXref
id: F6PMQ6
db: uniprot

Neurogenic locus notch homolog protein 2
type: ProteinReference
xref: PTHR45836:SF15
xref: uniprot Q04721 451
organism: Homo sapiens

uniprot F6YUR1 593
type: UnificationXref
id: F6YUR1
db: uniprot

uniprot P90623 277
type: UnificationXref
id: P90623
db: uniprot

uniprot E2RE71 710
type: UnificationXref
id: E2RE71
db: uniprot

uniprot Q9U1E8 324
type: UnificationXref
id: Q9U1E8
db: uniprot

Frizzled-3
type: ProteinReference
xref: PTHR11309:SF99
xref: uniprot O77438 402
organism: Drosophila melanogaster

uniprot P04426 824
type: UnificationXref
id: P04426
db: uniprot

Actin related protein
type: ProteinReference
xref: uniprot A8BV70 116
organism: Giardia intestinalis

AICD
type: Protein
entity reference: AICD
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa36 1154
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

LRP intracellular fragment s9 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LRP intracellular fragment
stoichiometric coefficient: 1.0

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot F6ZPQ4 192
organism: Monodelphis domestica

gammacatenin s67 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gammacatenin
stoichiometric coefficient: 1.0

Cytoplasmatic actin
type: ProteinReference
xref: uniprot E9FXV8 168
xref: PTHR11937:SF387
organism: Daphnia pulex

gammacatenin
type: Protein
entity reference: gammacatenin
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa23 1142
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot A7MB62 109
organism: Bos taurus

uniprot Q9QX29 508
type: UnificationXref
id: Q9QX29
db: uniprot

uniprot P33435 635
type: UnificationXref
id: P33435
db: uniprot

uniprot A0A1D5R3Z3 1001
type: UnificationXref
id: A0A1D5R3Z3
db: uniprot

Erb-B4 C-terminal fragment
type: Protein
entity reference: Erb-B4 C-terminal fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7BUW7 690
type: UnificationXref
id: F7BUW7
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A7S0V7 112
xref: PTHR11937:SF387
organism: Nematostella vectensis

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 273

uniprot A0A2J8Q404 341
type: UnificationXref
id: A0A2J8Q404
db: uniprot

beta catenin s70 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

Gamma-secretase subunit APH-1B
type: ProteinReference
xref: PTHR12889:SF1
xref: uniprot Q8C7N7 1042
organism: Mus musculus

Proprotein convertase subtilisin/kexin type 2
type: ProteinReference
xref: uniprot F6U002 962
organism: Xenopus tropicalis

uniprot P14923 933
type: UnificationXref
id: P14923
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot A0A1D5R803 734
xref: PTHR12027:SF73
organism: Macaca mulatta

uniprot E2QVP7 364
type: UnificationXref
id: E2QVP7
db: uniprot

uniprot Q61089 412
type: UnificationXref
id: Q61089
db: uniprot

Protein Wnt-8a
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot Q64527 866
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r59 1284
type: Stoichiometry
physical entity: E-cadherin intracellular fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 1283
type: Stoichiometry
physical entity: E-cadherin C-terminal fragment
stoichiometric coefficient: 1.0

uniprot F1PFZ9 915
type: UnificationXref
id: F1PFZ9
db: uniprot

PARTICIPANT STOICHIOMETRY r59 1285
type: Stoichiometry
physical entity: E-cadherin transmembrane fragment
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Erb_B4_intracellular_fragment-RIGHT__Erb_B4_intracellular_fragment-_r77
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1211
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 1210
left: Erb-B4 intracellular fragment
interaction type: TRANSPORT
right: Erb-B4 intracellular fragment

Transcription factor 7-like 2
type: ProteinReference
xref: uniprot Q924A0 902
xref: PTHR10373:SF32
organism: Mus musculus

Nectin 1alpha transmembrane fragment
type: ProteinReference
xref: P00134
comment: ENTITY_REFERENCE_NOTES=Long Name: Nectin 1alpha transmembrane fragment Synonym: Synonym not specified Accession: P00134
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Nectin 1_alpha__br_transmembrane_br_fragment
member entity reference: Nectin cell adhesion molecule 1
member entity reference: Nectin-1
member entity reference: Uncharacterized protein

Presenilin
type: ProteinReference
xref: uniprot F7C949 540
xref: PTHR10202:SF24
organism: Xenopus tropicalis

uniprot A4IF63 666
type: UnificationXref
id: A4IF63
db: uniprot

uniprot Q8VZD5 1067
type: UnificationXref
id: Q8VZD5
db: uniprot

Matrix metalloproteinase-20
type: ProteinReference
xref: uniprot O18767 619
xref: PTHR10201:SF125
organism: Bos taurus

Cadherin-1
type: ProteinReference
xref: PTHR24027:SF319
xref: uniprot P09803 346
organism: Mus musculus

TRPC7 isoform 1
type: ProteinReference
xref: uniprot H2QRJ4 489
xref: PTHR10117:SF9
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r82 1304
type: Stoichiometry
physical entity: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 1305
type: Stoichiometry
physical entity: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
stoichiometric coefficient: 1.0

TRPC4 isoform 1
type: ProteinReference
xref: PTHR10117:SF25
xref: uniprot H2R3J3 490
organism: Pan troglodytes

Frizzled class receptor 2
type: ProteinReference
xref: uniprot F6SH04 378
xref: PTHR11309:SF34
organism: Xenopus tropicalis

uniprot F6YVM2 594
type: UnificationXref
id: F6YVM2
db: uniprot

uniprot A0A2I3TV72 665
type: UnificationXref
id: A0A2I3TV72
db: uniprot

PARTICIPANT STOICHIOMETRY r29 1276
type: Stoichiometry
physical entity: gammacatenin
stoichiometric coefficient: 1.0

uniprot Q8WW43 1045
type: UnificationXref
id: Q8WW43
db: uniprot

PARTICIPANT STOICHIOMETRY r29 1275
type: Stoichiometry
physical entity: Complex (E-cadherin/beta-catenin/ gammacatenin/alphacatenin/ actin)
stoichiometric coefficient: 1.0

LRP intracellular fragment
type: ProteinReference
xref: P00173
comment: ENTITY_REFERENCE_NOTES=Long Name: LRP intracellular fragment Synonym: Synonym not specified Accession: P00173
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.LRP_br_intracellular_br_fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: Low-density lipoprotein receptor-related protein 1B
member entity reference: LDL receptor related protein 1
member entity reference: Low-density lipoprotein receptor-related protein 6
member entity reference: Low-density lipoprotein receptor-related protein
member entity reference: LDL receptor-related protein 1
member entity reference: LDL receptor related protein 3
member entity reference: LDL receptor related protein 6
member entity reference: LDL receptor related protein 4
member entity reference: Low-density lipoprotein receptor-related protein 2
member entity reference: Uncharacterized protein
member entity reference: Low-density lipoprotein receptor-related protein 3
member entity reference: LDL receptor related protein 1B
member entity reference: Low-density lipoprotein receptor-related protein 5
member entity reference: Low-density lipoprotein receptor-related protein 4
member entity reference: Low density lipoprotein receptor-related protein 3
member entity reference: Prolow-density lipoprotein receptor-related protein 1
member entity reference: LDL receptor related protein 2

PARTICIPANT STOICHIOMETRY r29 1278
type: Stoichiometry
physical entity: alphacatenin
stoichiometric coefficient: 1.0

uniprot F1MLJ8 369
type: UnificationXref
id: F1MLJ8
db: uniprot

PARTICIPANT STOICHIOMETRY r29 1277
type: Stoichiometry
physical entity: actin
stoichiometric coefficient: 1.0

uniprot F6UDX9 190
type: UnificationXref
id: F6UDX9
db: uniprot

PARTICIPANT STOICHIOMETRY r29 1279
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

PTHR11937:SF453
type: RelationshipXref
id: PTHR11937:SF453
db: PANTHER Family
relationship type: By Homology

Disintegrin and metalloproteinase domain-containing protein 17
type: ProteinReference
xref: uniprot Q9Z1K9 919
xref: PTHR45702:SF6
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: uniprot D4A9D7 761
xref: PTHR12027:SF92
organism: Rattus norvegicus

uniprot F6XUZ7 787
type: UnificationXref
id: F6XUZ7
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF389
xref: uniprot Q6XNL8 308
organism: Danio rerio

gammacatenin s47 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: gammacatenin
stoichiometric coefficient: 1.0

uniprot B1N2P0 135
type: UnificationXref
id: B1N2P0
db: uniprot

Frizzled class receptor 2
type: ProteinReference
xref: PTHR11309:SF34
xref: uniprot G3N2W8 388
organism: Bos taurus

uniprot E9FXV8 168
type: UnificationXref
id: E9FXV8
db: uniprot

uniprot O35468 820
type: UnificationXref
id: O35468
db: uniprot

Presenilin C-terminal fragment
type: Protein
entity reference: Presenilin C-terminal fragment
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Desmoplakin-3
type: ProteinReference
xref: uniprot F7H7V0 932
xref: PTHR45976:SF3
organism: Macaca mulatta

uniprot Q9R283 511
type: UnificationXref
id: Q9R283
db: uniprot

Presenilin C-terminal fragment
type: Protein
entity reference: Presenilin C-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 sa49 1130
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Frizzled class receptor 7a
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot Q6NV44 416
organism: Danio rerio

Neurogenic locus notch homolog protein 2
type: ProteinReference
xref: PTHR22804:SF52
xref: uniprot Q9QW30 456
organism: Rattus norvegicus

uniprot F1P625 581
type: UnificationXref
id: F1P625
db: uniprot

Low density lipoprotein receptor-related protein 3
type: ProteinReference
xref: uniprot E9Q1T6 49
xref: PTHR24270:SF22
organism: Mus musculus

PTHR11937:SF446
type: RelationshipXref
id: PTHR11937:SF446
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF445
type: RelationshipXref
id: PTHR11937:SF445
db: PANTHER Family
relationship type: By Homology

TCF/LEF
type: ProteinReference
xref: P00143
standard name: T-cell factor/lymphoid enhancer factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.TCF/LEF
comment: ENTITY_REFERENCE_NOTES=Long Name: T-cell factor/lymphoid enhancer factor Synonym: T-cell-specific transcription factor 1 Accession: P00143
member entity reference: TCF7 isoform 6
member entity reference: Lymphoid enhancer binding factor 1
member entity reference: Lymphoid enhancer-binding factor 1
member entity reference: Transcription factor 7-like 2
member entity reference: Transcription factor 7 like 1
member entity reference: Uncharacterized protein
member entity reference: Transcription factor 7-like 1
member entity reference: Lymphocyte enhancer binding factor 1
member entity reference: TCF7L1 isoform 2
member entity reference: Transcription factor 7-like 1-A

uniprot F6ZZG9 193
type: UnificationXref
id: F6ZZG9
db: uniprot

Frizzled-7
type: ProteinReference
xref: uniprot Q5BL72 409
xref: PTHR11309:SF31
organism: Xenopus tropicalis

uniprot A0A0G2KWQ6 465
type: UnificationXref
id: A0A0G2KWQ6
db: uniprot

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot O70421 400
organism: Mus musculus

GSK-3beta
type: Protein
entity reference: GSK-3beta
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot Q6P378 304
xref: PTHR11937:SF192
organism: Xenopus tropicalis

uniprot O75084 401
type: UnificationXref
id: O75084
db: uniprot

uniprot A7SEA7 114
type: UnificationXref
id: A7SEA7
db: uniprot

LRP transmembrane fragment
type: ProteinReference
xref: P00152
comment: ENTITY_REFERENCE_NOTES=Long Name: LRP transmembrane fragment Synonym: Synonym not specified Accession: P00152
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.LRP_br_transmembrane_br_fragment
member entity reference: Low-density lipoprotein receptor-related protein 1B
member entity reference: LDL receptor related protein 1
member entity reference: Low-density lipoprotein receptor-related protein 6
member entity reference: Low-density lipoprotein receptor-related protein
member entity reference: LDL receptor-related protein 1
member entity reference: LDL receptor related protein 3
member entity reference: LDL receptor related protein 6
member entity reference: LDL receptor related protein 4
member entity reference: Low-density lipoprotein receptor-related protein 2
member entity reference: Uncharacterized protein
member entity reference: Low-density lipoprotein receptor-related protein 3
member entity reference: LDL receptor related protein 1B
member entity reference: Low-density lipoprotein receptor-related protein 5
member entity reference: Low-density lipoprotein receptor-related protein 4
member entity reference: Low density lipoprotein receptor-related protein 3
member entity reference: Prolow-density lipoprotein receptor-related protein 1
member entity reference: LDL receptor related protein 2

actin
type: ProteinReference
xref: P00114
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.actin
comment: ENTITY_REFERENCE_NOTES=Long Name: actin Synonym: Synonym not specified Accession: P00114
member entity reference: Actin
member entity reference: Actin, alpha skeletal muscle
member entity reference: Actin A
member entity reference: Actin, cytoplasmic 1
member entity reference: Cytoplasmatic actin
member entity reference: Actin, alpha sarcomeric/skeletal
member entity reference: ACTA1 isoform 1
member entity reference: Actin-related protein 2
member entity reference: Actin alpha 1, skeletal muscle a
member entity reference: Uncharacterized protein
member entity reference: Actin, alpha cardiac muscle 1
member entity reference: Predicted protein
member entity reference: ACTC1 isoform 1
member entity reference: Actin, gamma-enteric smooth muscle
member entity reference: Actin 7
member entity reference: Actin-related protein 2-A
member entity reference: Actin, alpha 2, smooth muscle, aorta
member entity reference: Actin-2
member entity reference: Actin alpha cardiac muscle 1b
member entity reference: Actin, cytoskeletal 3B
member entity reference: Actin-related protein 2-B
member entity reference: Actin, aortic smooth muscle
member entity reference: Actin, cytoplasmic 2
member entity reference: Actin-18
member entity reference: Alpha-cardiac actin
member entity reference: Actin-7
member entity reference: actin, muscle-like
member entity reference: ACTin
member entity reference: Putative actin-22
member entity reference: Beta-actin-like protein 2
member entity reference: Actin-3
member entity reference: Actin-5C
member entity reference: Actin, larval muscle
member entity reference: Non-muscle actin 6.2

uniprot Q9DCZ9 1046
type: UnificationXref
id: Q9DCZ9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F0ZK40 173
xref: PTHR11937:SF154
organism: Dictyostelium purpureum

AGAP010442-PA
type: ProteinReference
xref: PTHR11309:SF126
xref: uniprot Q7QDV6 417
organism: Anopheles gambiae

Actin-7
type: ProteinReference
xref: uniprot P0C540 221
organism: Oryza sativa

uniprot A0A3Q1M4W2 469
type: UnificationXref
id: A0A3Q1M4W2
db: uniprot

Gamma-secretase subunit pen-2
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot Q86BE9 926
organism: Drosophila melanogaster

uniprot F6XUU0 191
type: UnificationXref
id: F6XUU0
db: uniprot

Short transient receptor potential channel 1
type: ProteinReference
xref: PTHR10117:SF56
xref: uniprot O18784 493
organism: Bos taurus

uniprot P43446 843
type: UnificationXref
id: P43446
db: uniprot

BACE-1
type: Protein
entity reference: BACE-1
feature: ACTIVE 517
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

PTHR45702:SF6
type: RelationshipXref
id: PTHR45702:SF6
db: PANTHER Family
relationship type: By Homology

Matrix metalloproteinase-24
type: ProteinReference
xref: uniprot Q9Y5R2 661
xref: PTHR10201:SF138
organism: Homo sapiens

E-cadherin transmembrane fragment
type: Protein
entity reference: E-cadherin transmembrane fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Tripartite motif-containing protein 2
type: ProteinReference
xref: uniprot Q9C040 677
organism: Homo sapiens

Nectin 1alpha
type: Protein
entity reference: Nectin 1alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa16 1146
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q10DV7 281
type: UnificationXref
id: Q10DV7
db: uniprot

ncbitaxon 5786 172
type: UnificationXref
id: 5786
db: ncbitaxon

Protein Wnt-1
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot P24257 834
organism: Danio rerio

Abeta
type: ProteinReference
xref: P00136
standard name: Beta-amyloid
comment: ENTITY_REFERENCE_NOTES=Long Name: Beta-amyloid Synonym: Synonym not specified Accession: P00136
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.A_beta_
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta A4 protein
member entity reference: Amyloid-beta precursor protein

uniprot Q6MG89 454
type: UnificationXref
id: Q6MG89
db: uniprot

uniprot F6QAX3 343
type: UnificationXref
id: F6QAX3
db: uniprot

uniprot Q5EB22 1039
type: UnificationXref
id: Q5EB22
db: uniprot

uniprot O70283 821
type: UnificationXref
id: O70283
db: uniprot

uniprot W4Y0D3 950
type: UnificationXref
id: W4Y0D3
db: uniprot

Afadin
type: ProteinReference
xref: uniprot Q9QZQ1 913
xref: PTHR10398:SF2
organism: Mus musculus

uniprot F6YMR3 480
type: UnificationXref
id: F6YMR3
db: uniprot

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF77
xref: uniprot P34889 840
organism: Caenorhabditis elegans

PTHR10878:SF8
type: RelationshipXref
id: PTHR10878:SF8
db: PANTHER Family
relationship type: By Homology

Nectin 1alpha C-terminal fragment
type: ProteinReference
xref: P00177
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: Nectin 1alpha C-terminal fragment Synonym: Synonym not specified Accession: P00177
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Nectin 1_alpha__br_C-terminal_br_fragment
member entity reference: Nectin cell adhesion molecule 1
member entity reference: Nectin-1
member entity reference: Uncharacterized protein

uniprot O45876 1037
type: UnificationXref
id: O45876
db: uniprot

PTHR10878:SF5
type: RelationshipXref
id: PTHR10878:SF5
db: PANTHER Family
relationship type: By Homology

uniprot H2QRJ4 489
type: UnificationXref
id: H2QRJ4
db: uniprot

PTHR10878:SF6
type: RelationshipXref
id: PTHR10878:SF6
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5Q7K7 96
type: UnificationXref
id: A0A1D5Q7K7
db: uniprot

uniprot A0A2I3RF60 86
type: UnificationXref
id: A0A2I3RF60
db: uniprot

uniprot G5ECN9 968
type: UnificationXref
id: G5ECN9
db: uniprot

PTHR11937:SF421
type: RelationshipXref
id: PTHR11937:SF421
db: PANTHER Family
relationship type: By Homology

uniprot Q9JKF6 707
type: UnificationXref
id: Q9JKF6
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot F7D1A1 789
organism: Xenopus tropicalis

PTHR11937:SF423
type: RelationshipXref
id: PTHR11937:SF423
db: PANTHER Family
relationship type: By Homology

Nectin 1alpha intracellular fragment
type: Protein
entity reference: Nectin 1alpha intracellular fragment
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q569 806
type: UnificationXref
id: H2Q569
db: uniprot

uniprot Q5M8T9 295
type: UnificationXref
id: Q5M8T9
db: uniprot

Si:dkeyp-80c12.7
type: ProteinReference
xref: uniprot B8JIQ1 1050
xref: PTHR24057:SF8
organism: Danio rerio

PTHR11937:SF416
type: RelationshipXref
id: PTHR11937:SF416
db: PANTHER Family
relationship type: By Homology

Presenilin N-terminal fragment
type: Protein
entity reference: Presenilin N-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa48 1128
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRIM3 protein
type: ProteinReference
xref: uniprot A7MB36 667
organism: Bos taurus

LDL receptor-related protein 1
type: ProteinReference
xref: PTHR24270:SF23
xref: uniprot G3V928 64
organism: Rattus norvegicus

APP
type: ProteinReference
xref: P00127
standard name: amyloid precursor protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: amyloid precursor protein Synonym: Synonym not specified Accession: P00127
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.APP
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta A4 protein
member entity reference: Amyloid-beta precursor protein

PARTICIPANT STOICHIOMETRY r81 1178
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r81 1177
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

uniprot A0A2I3TI13 736
type: UnificationXref
id: A0A2I3TI13
db: uniprot

ncbitaxon 7719 98
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot C3XYC6 148
type: UnificationXref
id: C3XYC6
db: uniprot

Transient receptor potential cation channel, subfamily C, member 1
type: ProteinReference
xref: PTHR10117:SF56
xref: uniprot F7DUN9 484
organism: Xenopus tropicalis

Shaggy-related protein kinase iota
type: ProteinReference
xref: uniprot Q39012 1065
organism: Arabidopsis thaliana

uniprot O75096 73
type: UnificationXref
id: O75096
db: uniprot

Frizzled-2
type: ProteinReference
xref: PTHR11309:SF126
xref: uniprot Q9VVX3 434
organism: Drosophila melanogaster

Shaggy-related protein kinase eta
type: ProteinReference
xref: uniprot Q39011 1064
organism: Arabidopsis thaliana

Transient receptor potential Ca2+ channel 6A
type: ProteinReference
xref: uniprot Q99N78 503
xref: PTHR10117:SF7
organism: Rattus norvegicus

Ire 1 s134 a169 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Histone acetyltransferase
type: ProteinReference
xref: uniprot A0A1D6UPT7 708
organism: Gallus gallus

PTHR12027:SF89
type: RelationshipXref
id: PTHR12027:SF89
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF88
type: RelationshipXref
id: PTHR12027:SF88
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF87
type: RelationshipXref
id: PTHR12027:SF87
db: PANTHER Family
relationship type: By Homology

uniprot Q9YH60 1076
type: UnificationXref
id: Q9YH60
db: uniprot

uniprot Q8ILW9 320
type: UnificationXref
id: Q8ILW9
db: uniprot

PTHR12027:SF92
type: RelationshipXref
id: PTHR12027:SF92
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF93
type: RelationshipXref
id: PTHR12027:SF93
db: PANTHER Family
relationship type: By Homology

alphacatenin
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa20 1136
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR12027:SF91
type: RelationshipXref
id: PTHR12027:SF91
db: PANTHER Family
relationship type: By Homology

uniprot A0A2J8NVW7 1003
type: UnificationXref
id: A0A2J8NVW7
db: uniprot

Protein Wnt-11
type: ProteinReference
xref: PTHR12027:SF34
xref: uniprot O73864 822
organism: Danio rerio

beta catenin s61 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

PTHR12027:SF94
type: RelationshipXref
id: PTHR12027:SF94
db: PANTHER Family
relationship type: By Homology

CSL
type: ProteinReference
xref: P00158
standard name: CBF1 Su1 and Lag1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.CSL
comment: ENTITY_REFERENCE_NOTES=Long Name: CBF1 Su1 and Lag1 Synonym: Synonym not specified Accession: P00158
member entity reference: Transcription factor cbf12
member entity reference: Rbpja protein
member entity reference: Uncharacterized protein
member entity reference: Recombining binding protein suppressor of hairless
member entity reference: Lin-12 And Glp-1 phenotype
member entity reference: Recombining binding protein suppressor of hairless-like protein
member entity reference: Suppressor of hairless protein
member entity reference: Recombination signal-binding protein for immunoglobulin kappa J region
member entity reference: Transcription factor cbf11
member entity reference: RBPJL isoform 1
member entity reference: RBPJ isoform 12
member entity reference: Recombination signal-binding protein for immunoglobulin kappa J region-like
member entity reference: Recombination signal binding protein for immunoglobulin kappa J region

CD44 antigen
type: ProteinReference
xref: uniprot P15379 461
xref: PTHR10225:SF6
organism: Mus musculus

uniprot F1PVS9 583
type: UnificationXref
id: F1PVS9
db: uniprot

uniprot P48614 845
type: UnificationXref
id: P48614
db: uniprot

Catenin beta-1
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot B6V8E6 937
organism: Canis lupus familiaris

Protein Wnt
type: ProteinReference
xref: uniprot Q9YGX6 886
xref: PTHR12027:SF33
organism: Gallus gallus

MODULATION
type: RelationshipTypeVocabulary

uniprot Q7PM79 1040
type: UnificationXref
id: Q7PM79
db: uniprot

FZD1 protein
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot A7MB15 359
organism: Bos taurus

PTHR12027:SF98
type: RelationshipXref
id: PTHR12027:SF98
db: PANTHER Family
relationship type: By Homology

uniprot E2R1T9 523
type: UnificationXref
id: E2R1T9
db: uniprot

uniprot P50282 642
type: UnificationXref
id: P50282
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

Ire-1
type: Protein
entity reference: Ire-1
feature: Ire 1 s134 a169 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot F6ULE6 1009
type: UnificationXref
id: F6ULE6
db: uniprot

Catenin beta-1
type: ProteinReference
xref: uniprot F7GNE4 942
xref: PTHR45976:SF4
organism: Macaca mulatta

Neuroendocrine convertase 2 isoform 1 preproprotein
type: ProteinReference
xref: uniprot F7GNE5 966
organism: Macaca mulatta

Frizzled-6
type: ProteinReference
xref: uniprot Q8WMU5 422
xref: PTHR11309:SF75
organism: Canis lupus familiaris

Erb-B4 N-terminal fragment
type: Protein
entity reference: Erb-B4 N-terminal fragment
comment: SPECIES_TYPE=PROTEIN

gammacatenin
type: Protein
entity reference: gammacatenin
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa13 1100
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1MQJ3 703
type: UnificationXref
id: F1MQJ3
db: uniprot

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Putative actin-9
type: ProteinReference
xref: PTHR11937:SF483
xref: uniprot P93738 278
organism: Arabidopsis thaliana

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 128

MMP21 isoform 1
type: ProteinReference
xref: uniprot H2Q2R2 608
xref: PTHR10201:SF147
organism: Pan troglodytes

Actin-related protein 2-B
type: ProteinReference
xref: PTHR11937:SF149
xref: uniprot Q56A35 289
organism: Danio rerio

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot P63259 256
xref: PTHR11937:SF414
organism: Rattus norvegicus

Erb-B4 N-terminal fragment
type: ProteinReference
xref: P00148
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Erb-B4_br_N-terminal_br_fragment
comment: ENTITY_REFERENCE_NOTES=Long Name: Erb-B4 N-terminal fragment Synonym: Synonym not specified Accession: P00148
member entity reference: Receptor protein-tyrosine kinase
member entity reference: Receptor tyrosine-protein kinase erbB-4

Recombining binding protein suppressor of hairless
type: ProteinReference
xref: uniprot Q3SZ41 1020
xref: PTHR10665:SF3
organism: Bos taurus

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63258 255
organism: Bos taurus

Protein Wnt
type: ProteinReference
xref: uniprot F7H7P6 796
xref: PTHR12027:SF84
organism: Macaca mulatta

uniprot A0A1D5NXB2 680
type: UnificationXref
id: A0A1D5NXB2
db: uniprot

uniprot P53474 236
type: UnificationXref
id: P53474
db: uniprot

Actin-87E
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P10981 224
organism: Drosophila melanogaster

Actin-2
type: ProteinReference
xref: uniprot P10984 225
xref: PTHR11937:SF470
organism: Caenorhabditis elegans

Actin-3
type: ProteinReference
xref: uniprot P0DM42 223
xref: PTHR11937:SF387
organism: Caenorhabditis elegans

Transcriptional activator HAC1
type: ProteinReference
xref: uniprot P41546 675
organism: Saccharomyces cerevisiae

PTHR12027:SF75
type: RelationshipXref
id: PTHR12027:SF75
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF72
type: RelationshipXref
id: PTHR12027:SF72
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: uniprot A0A140T847 731
xref: PTHR12027:SF70
organism: Bos taurus

PTHR12027:SF73
type: RelationshipXref
id: PTHR12027:SF73
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF70
type: RelationshipXref
id: PTHR12027:SF70
db: PANTHER Family
relationship type: By Homology

uniprot P56703 852
type: UnificationXref
id: P56703
db: uniprot

Frizzled class receptor 5
type: ProteinReference
xref: uniprot F6QAW3 374
xref: PTHR11309:SF141
organism: Xenopus tropicalis

DISSOCIATION
type: RelationshipTypeVocabulary

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P63267 259
organism: Homo sapiens

uniprot F7G3H1 89
type: UnificationXref
id: F7G3H1
db: uniprot

ncbitaxon 7739 144
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot P51136 1061
type: UnificationXref
id: P51136
db: uniprot

uniprot A0A2J8LQ70 738
type: UnificationXref
id: A0A2J8LQ70
db: uniprot

uniprot A9TYG3 130
type: UnificationXref
id: A9TYG3
db: uniprot

Protein kinase gsk3
type: ProteinReference
xref: uniprot V5ILY7 1077
organism: Neurospora crassa

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot P63261 258
xref: PTHR11937:SF414
organism: Homo sapiens

Notch 1
type: ProteinReference
xref: uniprot F1PDC7 440
xref: PTHR24033:SF176
organism: Canis lupus familiaris

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot P63260 257
xref: PTHR11937:SF414
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_r32
controller: Presenilin

uniprot Q553U6 286
type: UnificationXref
id: Q553U6
db: uniprot

uniprot P32361 25
type: UnificationXref
id: P32361
db: uniprot

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P63268 260
organism: Mus musculus

uniprot E2RIL8 367
type: UnificationXref
id: E2RIL8
db: uniprot

uniprot P16070 462
type: UnificationXref
id: P16070
db: uniprot

uniprot V5ILY7 1077
type: UnificationXref
id: V5ILY7
db: uniprot

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: uniprot P63269 261
xref: PTHR11937:SF201
organism: Rattus norvegicus

PTHR12027:SF77
type: RelationshipXref
id: PTHR12027:SF77
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF76
type: RelationshipXref
id: PTHR12027:SF76
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF78
type: RelationshipXref
id: PTHR12027:SF78
db: PANTHER Family
relationship type: By Homology

uniprot F1RCB6 178
type: UnificationXref
id: F1RCB6
db: uniprot

PTHR12027:SF84
type: RelationshipXref
id: PTHR12027:SF84
db: PANTHER Family
relationship type: By Homology

Dishevelled segment polarity protein 2
type: ProteinReference
xref: uniprot E2R7K2 686
xref: PTHR10878:SF8
organism: Canis lupus familiaris

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P63270 262
organism: Gallus gallus

uniprot P63258 255
type: UnificationXref
id: P63258
db: uniprot

PTHR12027:SF86
type: RelationshipXref
id: PTHR12027:SF86
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QP52 1023
xref: PTHR47965:SF69
organism: Monodelphis domestica

Cadherin 3
type: ProteinReference
xref: PTHR24027:SF267
xref: uniprot F6QAX3 343
organism: Xenopus tropicalis

Protein Wnt
type: ProteinReference
xref: uniprot F7H7P8 797
xref: PTHR12027:SF82
organism: Macaca mulatta

uniprot A0A1D5QFE1 733
type: UnificationXref
id: A0A1D5QFE1
db: uniprot

PTHR12027:SF81
type: RelationshipXref
id: PTHR12027:SF81
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF82
type: RelationshipXref
id: PTHR12027:SF82
db: PANTHER Family
relationship type: By Homology

Frizzled-7
type: ProteinReference
xref: uniprot A0A1D5PEJ9 353
xref: PTHR11309:SF31
organism: Gallus gallus

Fe65
type: ProteinReference
xref: P00126
standard name: Amyloid precursor binding protein, family B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor binding protein, family B Synonym: Rir Accession: P00126
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Fe65
member entity reference: Amyloid-beta A4 precursor protein-binding family B member 1
member entity reference: Amyloid beta precursor protein binding family B member 2
member entity reference: Amyloid beta precursor protein binding family B member 3
member entity reference: Amyloid-beta A4 precursor protein-binding family B member 3
member entity reference: Amyloid beta precursor protein binding family B member 1
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta A4 precursor protein-binding family B member 2

Transient receptor potential cation channel subfamily C member 1
type: ProteinReference
xref: uniprot F6TZU4 477
xref: PTHR10117:SF56
organism: Monodelphis domestica

uniprot P63260 257
type: UnificationXref
id: P63260
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23103:SF7
xref: uniprot E1C440 36
organism: Gallus gallus

Matrix metalloproteinase-20
type: ProteinReference
xref: uniprot P57748 647
xref: PTHR10201:SF125
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R884 662
organism: Macaca mulatta

Protein Wnt
type: ProteinReference
xref: uniprot D3ZCR1 754
xref: PTHR12027:SF82
organism: Rattus norvegicus

uniprot A0A2I3TWA0 331
type: UnificationXref
id: A0A2I3TWA0
db: uniprot

NICD
type: Protein
entity reference: NICD
feature: COMPLEX PARTICIPANT BINDING FEATURE s262 sa6 1086
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR10117:SF25
xref: uniprot F6TA59 476
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r48 1197
type: Stoichiometry
physical entity: Complex (APP/Fe65)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 1195
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

Matrix metallopeptidase 16
type: ProteinReference
xref: uniprot F6SV12 588
xref: PTHR10201:SF26
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r48 1196
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

uniprot C3YYJ8 750
type: UnificationXref
id: C3YYJ8
db: uniprot

uniprot Q6GL20 415
type: UnificationXref
id: Q6GL20
db: uniprot

PARTICIPANT STOICHIOMETRY r76 1221
type: Stoichiometry
physical entity: Complex (AICD/Fe65)
stoichiometric coefficient: 1.0

Amyloid-beta A4 precursor protein-binding family B member 3
type: ProteinReference
xref: uniprot O95704 531
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: uniprot X1WEJ5 887
xref: PTHR12027:SF73
organism: Danio rerio

PTHR45976:SF3
type: RelationshipXref
id: PTHR45976:SF3
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r76 1222
type: Stoichiometry
physical entity: Complex (AICD/Fe65)
stoichiometric coefficient: 1.0

Glycogen synthase kinase 3
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot Q9YH60 1076
organism: Danio rerio

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot P63239 989
organism: Mus musculus

PTHR45976:SF4
type: RelationshipXref
id: PTHR45976:SF4
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot F1N6L8 775
organism: Bos taurus

uniprot H9EPM1 1054
type: UnificationXref
id: H9EPM1
db: uniprot

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot H2R439 973
organism: Pan troglodytes

uniprot Q9VVX3 434
type: UnificationXref
id: Q9VVX3
db: uniprot

Afadin, adherens junction formation factor
type: ProteinReference
xref: uniprot F1PSU6 910
xref: PTHR10398:SF2
organism: Canis lupus familiaris

uniprot F6XN03 478
type: UnificationXref
id: F6XN03
db: uniprot

TCF/LEF
type: Protein
entity reference: TCF/LEF
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa42 1094
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot Q9DEB8 874
organism: Gallus gallus

uniprot Q0VCX4 947
type: UnificationXref
id: Q0VCX4
db: uniprot

uniprot F6Z2A8 595
type: UnificationXref
id: F6Z2A8
db: uniprot

uniprot Q8CHL0 419
type: UnificationXref
id: Q8CHL0
db: uniprot

Presenilin
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot F7A2E1 538
organism: Macaca mulatta

Receptor protein-tyrosine kinase
type: ProteinReference
xref: PTHR24416:SF90
xref: uniprot F7GAV2 90
organism: Ornithorhynchus anatinus

uniprot Q6DIV8 301
type: UnificationXref
id: Q6DIV8
db: uniprot

Recombination signal-binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: PTHR10665:SF3
xref: uniprot M0R7Q3 1012
organism: Rattus norvegicus

FURIN isoform 1
type: ProteinReference
xref: PTHR42884:SF1
xref: uniprot H2QA34 970
organism: Pan troglodytes

TCF/LEF
type: Protein
entity reference: TCF/LEF
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR10373:SF11
xref: uniprot F6ZBJ4 897
organism: Monodelphis domestica

uniprot Q7PM77 868
type: UnificationXref
id: Q7PM77
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot A6H6X8 743
organism: Bos taurus

Actin, beta like 2
type: ProteinReference
xref: PTHR11937:SF278
xref: uniprot H2QE24 207
organism: Pan troglodytes

Frizzled-4
type: ProteinReference
xref: uniprot Q9QZH0 429
xref: PTHR11309:SF23
organism: Rattus norvegicus

Lymphoid enhancer-binding factor 1
type: ProteinReference
xref: uniprot P27782 900
xref: PTHR10373:SF11
organism: Mus musculus

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa35 1152
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gamma-secretase subunit APH-1B isoform 1
type: ProteinReference
xref: PTHR12889:SF1
xref: uniprot H9G0E6 1036
organism: Macaca mulatta

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot Q8CGU6 336
organism: Rattus norvegicus

Actin-5C
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P10987 227
organism: Drosophila melanogaster

Actin-4
type: ProteinReference
xref: PTHR11937:SF471
xref: uniprot P10986 226
organism: Caenorhabditis elegans

uniprot P78536 917
type: UnificationXref
id: P78536
db: uniprot

Actin
type: ProteinReference
xref: uniprot P10989 228
xref: PTHR11937:SF387
organism: Schizosaccharomyces pombe

MODULATION
type: Control
xref: MODULATION
controlled: Gene transcription
controller: Complex (beta-catenin/TCF/ LEF)

uniprot P22724 830
type: UnificationXref
id: P22724
db: uniprot

uniprot F6TCQ4 781
type: UnificationXref
id: F6TCQ4
db: uniprot

Presenilin
type: ProteinReference
xref: uniprot H2R821 542
xref: PTHR10202:SF24
organism: Pan troglodytes

Presenilin
type: ProteinReference
xref: P00129
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Presenilin
comment: ENTITY_REFERENCE_NOTES=Long Name: Presenilin Synonym: Synonym not specified Accession: P00129
member entity reference: Presenilin-2
member entity reference: Presenilin
member entity reference: Presenilin-like protein At2g29900
member entity reference: Presenilin-1
member entity reference: Presenilin spe-4
member entity reference: Presenilin sel-12
member entity reference: Presenilin homolog
member entity reference: Presenilin-like protein At1g08700
member entity reference: Presenilin hop-1

uniprot Q9R0T4 350
type: UnificationXref
id: Q9R0T4
db: uniprot

uniprot P98164 78
type: UnificationXref
id: P98164
db: uniprot

Receptor protein-tyrosine kinase
type: ProteinReference
xref: PTHR24416:SF90
xref: uniprot A0A2I3RF60 86
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2A6CRA8 99
xref: PTHR11937:SF387
organism: Pristionchus pacificus

uniprot P17553 828
type: UnificationXref
id: P17553
db: uniprot

ncbitaxon 418459 165
type: UnificationXref
id: 418459
db: ncbitaxon

uniprot F6RPG1 377
type: UnificationXref
id: F6RPG1
db: uniprot

uniprot D3ZFS0 756
type: UnificationXref
id: D3ZFS0
db: uniprot

uniprot H2QIY0 69
type: UnificationXref
id: H2QIY0
db: uniprot

uniprot P55196 912
type: UnificationXref
id: P55196
db: uniprot

PARTICIPANT STOICHIOMETRY r39 1243
type: Stoichiometry
physical entity: HAC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r39 1244
type: Stoichiometry
physical entity: HAC1
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot D4A9J2 762
organism: Rattus norvegicus

uniprot P51141 696
type: UnificationXref
id: P51141
db: uniprot

Tripartite motif-containing 2
type: ProteinReference
xref: uniprot Q6DJS4 676
organism: Xenopus tropicalis

Notch 4
type: ProteinReference
xref: PTHR24044:SF470
xref: uniprot Q6MG89 454
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF88
xref: uniprot H2R817 810
organism: Pan troglodytes

Protein Wnt-5
type: ProteinReference
xref: uniprot P28466 839
xref: PTHR12027:SF77
organism: Drosophila melanogaster

uniprot F6QAW3 374
type: UnificationXref
id: F6QAW3
db: uniprot

Protein Wnt-2
type: ProteinReference
xref: uniprot P28465 838
xref: PTHR12027:SF112
organism: Drosophila melanogaster

LDL receptor related protein 1B
type: ProteinReference
xref: uniprot H2QIS5 68
xref: PTHR22722:SF6
organism: Pan troglodytes

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__GSK_3beta-RIGHT__GSK_3beta-_re55
controller: Dsh

PTHR12027:SF33
type: RelationshipXref
id: PTHR12027:SF33
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF34
type: RelationshipXref
id: PTHR12027:SF34
db: PANTHER Family
relationship type: By Homology

uniprot P31266 1018
type: UnificationXref
id: P31266
db: uniprot

uniprot F7GFT1 602
type: UnificationXref
id: F7GFT1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5REM7 888
xref: PTHR10373:SF11
organism: Macaca mulatta

Non-muscle actin 6.2
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B3S5E4 140
organism: Trichoplax adhaerens

Protein Wnt-10a
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot P70701 856
organism: Mus musculus

uniprot Q0PY50 1038
type: UnificationXref
id: Q0PY50
db: uniprot

uniprot F1LNP8 702
type: UnificationXref
id: F1LNP8
db: uniprot

uniprot E3K4I1 164
type: UnificationXref
id: E3K4I1
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Nectin_1alpha_C_terminal_fragment-RIGHT__Nectin_1alpha_intracellular_fragment-_Nectin_1alpha_transmembrane_fragment-_r63
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

uniprot Q2QL96 861
type: UnificationXref
id: Q2QL96
db: uniprot

uniprot F6TA59 476
type: UnificationXref
id: F6TA59
db: uniprot

PTHR10225:SF6
type: RelationshipXref
id: PTHR10225:SF6
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9031 37
type: UnificationXref
id: 9031
db: ncbitaxon

Beta-actin-like protein 2
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot Q8BFZ3 317
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZTX6 161
xref: PTHR11937:SF446
organism: Branchiostoma floridae

Gene transcription
type: Pathway

uniprot Q8WMU5 422
type: UnificationXref
id: Q8WMU5
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot E2RTG8 769
xref: PTHR12027:SF91
organism: Canis lupus familiaris

Actin-57B
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P53501 243
organism: Drosophila melanogaster

uniprot Q4JLT0 864
type: UnificationXref
id: Q4JLT0
db: uniprot

uniprot A0A2I3TC20 519
type: UnificationXref
id: A0A2I3TC20
db: uniprot

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot Q92542 338
organism: Homo sapiens

uniprot Q02257 934
type: UnificationXref
id: Q02257
db: uniprot

Protein Wnt-7a
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot O00755 817
organism: Homo sapiens

Presenilin-1
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot Q4JIM4 553
organism: Gallus gallus

TRANSPORT
type: RelationshipTypeVocabulary

uniprot F1PCS0 53
type: UnificationXref
id: F1PCS0
db: uniprot

uniprot F7CIV4 196
type: UnificationXref
id: F7CIV4
db: uniprot

Wnt
type: Protein
entity reference: Wnt
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 sa43 1174
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR10117:SF25
xref: uniprot A0A1D5QA06 466
organism: Macaca mulatta

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 108

TCF7L1 isoform 2
type: ProteinReference
xref: uniprot H2QI87 899
xref: PTHR10373:SF25
organism: Pan troglodytes

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

Uncharacterized protein
type: ProteinReference
xref: PTHR10201:SF143
xref: uniprot F7FE85 600
organism: Macaca mulatta

uniprot Q63415 995
type: UnificationXref
id: Q63415
db: uniprot

uniprot H2QJZ8 971
type: UnificationXref
id: H2QJZ8
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF87
xref: uniprot B1WBR9 747
organism: Rattus norvegicus

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot F1PXA0 54
xref: PTHR46513:SF16
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__E_cadherin_C_terminal_fragment-RIGHT__E_cadherin_intracellular_fragment-_E_cadherin_transmembrane_fragment-_r59
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

uniprot H2R591 395
type: UnificationXref
id: H2R591
db: uniprot

uniprot F7CEB1 964
type: UnificationXref
id: F7CEB1
db: uniprot

uniprot O08674 1013
type: UnificationXref
id: O08674
db: uniprot

uniprot J9P9P7 492
type: UnificationXref
id: J9P9P7
db: uniprot

uniprot A0A1D5RG25 663
type: UnificationXref
id: A0A1D5RG25
db: uniprot

uniprot Q9UBV4 883
type: UnificationXref
id: Q9UBV4
db: uniprot

uniprot O88272 625
type: UnificationXref
id: O88272
db: uniprot

uniprot F7FE85 600
type: UnificationXref
id: F7FE85
db: uniprot

uniprot Q61144 554
type: UnificationXref
id: Q61144
db: uniprot

uniprot E9FRT1 166
type: UnificationXref
id: E9FRT1
db: uniprot

uniprot F6ZDZ8 460
type: UnificationXref
id: F6ZDZ8
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot Q9U6V0 882
xref: PTHR12027:SF77
organism: Ciona intestinalis

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot A0A2I3TI13 736
organism: Pan troglodytes

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 136

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 8

LRP
type: Protein
entity reference: LRP
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gamma-secretase subunit pen-2
type: ProteinReference
xref: uniprot Q9U357 930
xref: PTHR16318:SF0
organism: Caenorhabditis elegans

uniprot Q9CQR7 928
type: UnificationXref
id: Q9CQR7
db: uniprot

Protein Wnt-6
type: ProteinReference
xref: PTHR12027:SF72
xref: uniprot Q9Y6F9 885
organism: Homo sapiens

uniprot F7G8Z6 601
type: UnificationXref
id: F7G8Z6
db: uniprot

Frizzled class receptor 3
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot F6RPG1 377
organism: Xenopus tropicalis

uniprot F1MP23 370
type: UnificationXref
id: F1MP23
db: uniprot

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot A0A2I3TWA0 331
organism: Pan troglodytes

uniprot F1N1K8 52
type: UnificationXref
id: F1N1K8
db: uniprot

uniprot G3V6L1 389
type: UnificationXref
id: G3V6L1
db: uniprot

Short transient receptor potential channel 4
type: ProteinReference
xref: PTHR10117:SF25
xref: uniprot Q9UBN4 512
organism: Homo sapiens

Serine/threonine-protein kinase/endoribonuclease IRE1
type: ProteinReference
xref: uniprot Q9EQY0 32
xref: PTHR13954:SF17
organism: Mus musculus

uniprot H2QBE4 345
type: UnificationXref
id: H2QBE4
db: uniprot

uniprot F6PWM3 373
type: UnificationXref
id: F6PWM3
db: uniprot

uniprot A2FA04 102
type: UnificationXref
id: A2FA04
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45836:SF12
xref: uniprot F7H8I5 443
organism: Macaca mulatta

Protein Wnt
type: ProteinReference
xref: uniprot F6PMQ6 777
xref: PTHR12027:SF33
organism: Monodelphis domestica

Wnt s77 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Wnt
stoichiometric coefficient: 1.0

Actin, cytoskeletal 3B
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P18499 229
organism: Strongylocentrotus purpuratus

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 56

uniprot O75197 74
type: UnificationXref
id: O75197
db: uniprot

Frizzled-6
type: ProteinReference
xref: uniprot O60353 399
xref: PTHR11309:SF75
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r50 1307
type: Stoichiometry
physical entity: Complex (AICD/Fe65)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r50 1308
type: Stoichiometry
physical entity: Abeta
stoichiometric coefficient: 1.0

ncbitaxon 284812 24
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot P12023 41
type: UnificationXref
id: P12023
db: uniprot

Frizzled-2
type: ProteinReference
xref: uniprot Q14332 407
xref: PTHR11309:SF34
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MM00 11
xref: PTHR13954:SF17
organism: Bos taurus

uniprot Q9UL62 513
type: UnificationXref
id: Q9UL62
db: uniprot

ADAM metallopeptidase domain 17
type: ProteinReference
xref: uniprot H2R900 916
xref: PTHR45702:SF6
organism: Pan troglodytes

Transient receptor potential cation channel subfamily C member 1
type: ProteinReference
xref: uniprot A0A2I3T3G9 467
xref: PTHR10117:SF56
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r50 1306
type: Stoichiometry
physical entity: Complex (C99/Fe65)
stoichiometric coefficient: 1.0

uniprot B7PBG2 141
type: UnificationXref
id: B7PBG2
db: uniprot

uniprot Q9R216 430
type: UnificationXref
id: Q9R216
db: uniprot

Aph-1
type: ProteinReference
xref: P00170
standard name: Anterior pharynx defective-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Anterior pharynx defective-1 Synonym: Synonym not specified Accession: P00170
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Aph-1
member entity reference: Gamma-secretase subunit APH-1B isoform 1
member entity reference: AGAP009816-PA
member entity reference: Gamma-secretase subunit APH-1B
member entity reference: APH1B isoform 1
member entity reference: Gamma-secretase subunit APH-1A
member entity reference: Gamma-secretase subunit aph-1
member entity reference: Aph-1 homolog A, gamma-secretase subunit
member entity reference: Gamma-secretase subunit APH1-like
member entity reference: Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a
member entity reference: Gamma-secretase subunit Aph-1b
member entity reference: APH-1B'
member entity reference: Gamma-secretase subunit Aph-1
member entity reference: Putative gamma-secretase subunit APH-1C
member entity reference: Anterior pharynx defective 1 homolog A

uniprot P61160 250
type: UnificationXref
id: P61160
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot F6SCP4 185
organism: Ciona intestinalis

uniprot E1BPT8 439
type: UnificationXref
id: E1BPT8
db: uniprot

uniprot Q7YTV5 314
type: UnificationXref
id: Q7YTV5
db: uniprot

uniprot P02574 216
type: UnificationXref
id: P02574
db: uniprot

E-cadherin C-terminal fragment
type: Protein
entity reference: E-cadherin C-terminal fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Os10g0521700 protein
type: ProteinReference
xref: uniprot Q8LNI5 1066
organism: Oryza sativa

uniprot Q9UBG7 1021
type: UnificationXref
id: Q9UBG7
db: uniprot

uniprot O60353 399
type: UnificationXref
id: O60353
db: uniprot

Pen 2 s82 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pen-2
stoichiometric coefficient: 1.0

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF409
xref: uniprot A0A2I3TS83 101
organism: Pan troglodytes

Complex (AICD/Fe65/ Tip60)
type: Complex
component stoichiometry: Fe65 s35 sa39 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tip60 s36 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: AICD s34 sa38 STOICHIOMETRY ID COMPLEX
component: Tip60
component: Fe65
component: AICD
feature: COMPLEX BINDING FEATURE s177 a216 1109
feature: COMPLEX BINDING FEATURE s177 a216 1105
feature: COMPLEX BINDING FEATURE s177 a216 1107
cellular location: nucleus

beta-catenin
type: Protein
entity reference: beta-catenin
feature: beta catenin s61 sa22 rs2
feature: Ser beta catenin s61 sa22 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa22 1140
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1N797 579
type: UnificationXref
id: F1N797
db: uniprot

uniprot Q3U435 725
type: UnificationXref
id: Q3U435
db: uniprot

uniprot P28053 633
type: UnificationXref
id: P28053
db: uniprot

Frizzled-2
type: ProteinReference
xref: uniprot Q9JIP6 426
xref: PTHR11309:SF34
organism: Mus musculus

gammacatenin
type: Protein
entity reference: gammacatenin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
type: Complex
component stoichiometry: Pen 2 s16 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: Aph 1 s15 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: Nicastrin s13 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: Presenilin C terminal fragment s20 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: Presenilin N terminal fragment s17 sa28 STOICHIOMETRY ID COMPLEX
component: Pen-2
component: Aph-1
component: Nicastrin
component: Presenilin N-terminal fragment
component: Presenilin C-terminal fragment
feature: COMPLEX BINDING FEATURE s151 a184 1117
feature: COMPLEX BINDING FEATURE s151 a184 1111
feature: COMPLEX BINDING FEATURE s151 a184 1115
feature: COMPLEX BINDING FEATURE s151 a184 1113
feature: COMPLEX BINDING FEATURE s151 a184 1119
feature: ACTIVE 517
cellular location: Golgi apparatus

uniprot Q9QZC1 509
type: UnificationXref
id: Q9QZC1
db: uniprot

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot P57716 334
organism: Mus musculus

MODULATION
type: Control
xref: MODULATION
controlled: Gene transcription
controller: HAC1

beta-catenin
type: Protein
entity reference: beta-catenin
feature: beta catenin s87 a103 rs2
feature: Ser beta catenin s87 a103 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein Wnt-9a
type: ProteinReference
xref: uniprot O14904 818
xref: PTHR12027:SF75
organism: Homo sapiens

Protein Wnt-9b
type: ProteinReference
xref: PTHR12027:SF84
xref: uniprot O14905 819
organism: Homo sapiens

Actin-3
type: ProteinReference
xref: PTHR11937:SF411
xref: uniprot Q10AZ4 280
organism: Oryza sativa

uniprot F7GNE4 942
type: UnificationXref
id: F7GNE4
db: uniprot

Presenilin
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot F6YF14 537
organism: Xenopus tropicalis

Frizzled-6
type: ProteinReference
xref: uniprot F6SV99 379
xref: PTHR11309:SF75
organism: Macaca mulatta

uniprot H3F5B4 208
type: UnificationXref
id: H3F5B4
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F6SLU9 779
xref: PTHR12027:SF91
organism: Macaca mulatta

Low-density lipoprotein receptor-related protein 6
type: ProteinReference
xref: PTHR24270:SF12
xref: uniprot O75581 75
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot E1BKL2 765
organism: Bos taurus

FZD3 isoform 1
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot A0A2J8N8E6 356
organism: Pan troglodytes

uniprot B1WBR9 747
type: UnificationXref
id: B1WBR9
db: uniprot

Recombining binding protein suppressor of hairless-like protein
type: ProteinReference
xref: uniprot O08674 1013
xref: PTHR10665:SF2
organism: Mus musculus

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 30

uniprot A7MB15 359
type: UnificationXref
id: A7MB15
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YL51 58
xref: PTHR22722:SF6
organism: Macaca mulatta

Dishevelled segment polarity protein 3a
type: ProteinReference
xref: uniprot B8JMI2 682
xref: PTHR10878:SF6
organism: Danio rerio

Actin beta
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F6UDX9 190
organism: Ornithorhynchus anatinus

ncbitaxon 10116 7
type: UnificationXref
id: 10116
db: ncbitaxon

Receptor protein-tyrosine kinase
type: ProteinReference
xref: PTHR24416:SF90
xref: uniprot F7G3H1 89
organism: Macaca mulatta

TRUNCATION_LEFT__Notch_transmembrane_fragment-RIGHT__Notch_fragment-_NICD-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1204
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1202
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1203
left: Notch transmembrane fragment
interaction type: TRUNCATION
right: Notch fragment
right: NICD

uniprot F6SZP3 57
type: UnificationXref
id: F6SZP3
db: uniprot

Histone acetyltransferase KAT7
type: ProteinReference
xref: uniprot O95251 717
organism: Homo sapiens

uniprot F6YL51 58
type: UnificationXref
id: F6YL51
db: uniprot

uniprot P22223 349
type: UnificationXref
id: P22223
db: uniprot

uniprot O75581 75
type: UnificationXref
id: O75581
db: uniprot

uniprot F7H6Q8 487
type: UnificationXref
id: F7H6Q8
db: uniprot

uniprot Q24298 352
type: UnificationXref
id: Q24298
db: uniprot

uniprot F6ZQ88 788
type: UnificationXref
id: F6ZQ88
db: uniprot

Trichomonas vaginalis
type: BioSource
xref: ncbitaxon 5722 103

Danio rerio
type: BioSource
xref: ncbitaxon 7955 177

Frizzled class receptor 5
type: ProteinReference
xref: PTHR11309:SF136
xref: uniprot E2QVP7 364
organism: Canis lupus familiaris

Tip60
type: Protein
entity reference: Tip60
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa40 1110
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F7EA78 485
type: UnificationXref
id: F7EA78
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q7K7 96
xref: PTHR11937:SF414
organism: Macaca mulatta

uniprot F7F2K2 387
type: UnificationXref
id: F7F2K2
db: uniprot

uniprot Q10AZ4 280
type: UnificationXref
id: Q10AZ4
db: uniprot

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot Q8GUM5 337
organism: Arabidopsis thaliana

Protein Wnt
type: ProteinReference
xref: uniprot F7DI28 791
xref: PTHR12027:SF87
organism: Xenopus tropicalis

uniprot P62736 252
type: UnificationXref
id: P62736
db: uniprot

uniprot C3XPR5 748
type: UnificationXref
id: C3XPR5
db: uniprot

ncbitaxon 54126 100
type: UnificationXref
id: 54126
db: ncbitaxon

Protein Wnt-10b
type: ProteinReference
xref: PTHR12027:SF76
xref: uniprot O00744 816
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6WBV7 590
xref: PTHR10201:SF147
organism: Macaca mulatta

Notch fragment
type: ProteinReference
xref: P00154
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Notch_br_fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: Notch fragment Synonym: Synonym not specified Accession: P00154
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Notch 4
member entity reference: Notch 3
member entity reference: Neurogenic locus Notch protein
member entity reference: Notch 1
member entity reference: NOTCH3 isoform 1
member entity reference: NOTCH1 isoform 1

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R3Z3 1001
xref: PTHR10665:SF3
organism: Macaca mulatta

uniprot F1MCT1 958
type: UnificationXref
id: F1MCT1
db: uniprot

Complex (AICD/Fe65)
type: Complex
component stoichiometry: Fe65 s31 sa37 STOICHIOMETRY ID COMPLEX
component stoichiometry: AICD s30 sa36 STOICHIOMETRY ID COMPLEX
component: AICD
component: Fe65
feature: COMPLEX BINDING FEATURE s176 a215 1155
feature: COMPLEX BINDING FEATURE s176 a215 1153
cellular location: nucleus

uniprot F7H8I5 443
type: UnificationXref
id: F7H8I5
db: uniprot

Notch 4
type: ProteinReference
xref: uniprot H2RDK4 446
xref: PTHR24044:SF450
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r7 1184
type: Stoichiometry
physical entity: NICD
stoichiometric coefficient: 1.0

uniprot H9FVB9 974
type: UnificationXref
id: H9FVB9
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r42
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 1236
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 1237
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

HETERODIMER_ASSOCIATION_LEFT__Fe65-_APP-RIGHT__Complex__APP_Fe65_-_r48
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1197
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1196
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1195
left: APP
left: Fe65
interaction type: HETERODIMER_ASSOCIATION
right: Complex (APP/Fe65)

PARTICIPANT STOICHIOMETRY r7 1185
type: Stoichiometry
physical entity: CSL
stoichiometric coefficient: 1.0

uniprot Q9JI18 83
type: UnificationXref
id: Q9JI18
db: uniprot

Frizzled class receptor 4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot F7F2K2 387
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r7 1186
type: Stoichiometry
physical entity: Complex (CSL/NICD)
stoichiometric coefficient: 1.0

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: uniprot Q8JHF0 927
xref: PTHR16318:SF0
organism: Danio rerio

ncbitaxon 9606 21
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q9WVC5 515
type: UnificationXref
id: Q9WVC5
db: uniprot

uniprot A2G1K5 104
type: UnificationXref
id: A2G1K5
db: uniprot

Protein kinase gsk3
type: ProteinReference
xref: uniprot Q10452 1063
organism: Schizosaccharomyces pombe

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 95

ERN1 isoform 4
type: ProteinReference
xref: PTHR13954:SF17
xref: uniprot K7BU85 19
organism: Pan troglodytes

uniprot Q498S8 408
type: UnificationXref
id: Q498S8
db: uniprot

uniprot F1MKH8 575
type: UnificationXref
id: F1MKH8
db: uniprot

uniprot O74412 1015
type: UnificationXref
id: O74412
db: uniprot

Pen 2 s16 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pen-2
stoichiometric coefficient: 1.0

uniprot D4AEG0 1006
type: UnificationXref
id: D4AEG0
db: uniprot

uniprot F6SXE3 780
type: UnificationXref
id: F6SXE3
db: uniprot

Non-muscle actin 6.2
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B3RX77 139
organism: Trichoplax adhaerens

TRANSPORT LEFT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment -RIGHT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment - r82
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 1305
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 1304
left: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
display name: TRANSPORT_LEFT__Complex__Nicastrin_Aph_1__Pen_2_Presenilin_N_terminal_fragment__Presenilin_C_terminal_fragment_-RIGHT__Complex__Nicastrin_Aph_1__Pen_2_Presenilin_N_terminal_fragment__Presenilin_C_terminal_fragment_-_r82
interaction type: TRANSPORT
right: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XP71 592
xref: PTHR10201:SF26
organism: Macaca mulatta

Frizzled class receptor 7
type: ProteinReference
xref: uniprot D4ACM8 363
xref: PTHR11309:SF31
organism: Rattus norvegicus

uniprot Q5M7U6 294
type: UnificationXref
id: Q5M7U6
db: uniprot

PTHR11937:SF483
type: RelationshipXref
id: PTHR11937:SF483
db: PANTHER Family
relationship type: By Homology

Actin (Fragment)
type: ProteinReference
xref: uniprot A2HNG1 105
organism: Trichomonas vaginalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F7D527 671
organism: Monodelphis domestica

uniprot P04628 825
type: UnificationXref
id: P04628
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F6ZQ88 788
xref: PTHR12027:SF101
organism: Xenopus tropicalis

Matrix metalloproteinase-9
type: ProteinReference
xref: uniprot P14780 631
xref: PTHR10201:SF30
organism: Homo sapiens

uniprot F1LMI3 342
type: UnificationXref
id: F1LMI3
db: uniprot

TRUNCATION_LEFT__Complex__E_cadherin_beta_catenin__gammacatenin_alphacatenin__actin_-RIGHT__E_cadherin_C_terminal_fragment-_E_cadherin_N_terminal_fragment-_r28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1282
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1280
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 1281
left: Complex (E-cadherin/beta-catenin/ gammacatenin/alphacatenin/ actin)
interaction type: TRUNCATION
right: E-cadherin N-terminal fragment
right: E-cadherin C-terminal fragment

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot Q5BL41 290
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N797 579
xref: PTHR10201:SF26
organism: Bos taurus

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot O18840 211
xref: PTHR11937:SF192
organism: Canis lupus familiaris

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: PTHR24270:SF12
xref: uniprot A0A0G2K0H3 42
organism: Rattus norvegicus

uniprot H2QIS5 68
type: UnificationXref
id: H2QIS5
db: uniprot

Suppressor of hairless protein
type: ProteinReference
xref: uniprot P28159 1017
organism: Drosophila melanogaster

uniprot O75382 674
type: UnificationXref
id: O75382
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7RU31 110
organism: Nematostella vectensis

PTHR11309:SF81
type: RelationshipXref
id: PTHR11309:SF81
db: PANTHER Family
relationship type: By Homology

Nectin cell adhesion molecule 1
type: ProteinReference
xref: PTHR23277:SF69
xref: uniprot F1MQJ3 703
organism: Bos taurus

uniprot P09544 826
type: UnificationXref
id: P09544
db: uniprot

PTHR11309:SF86
type: RelationshipXref
id: PTHR11309:SF86
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TEQ9 569
type: UnificationXref
id: A0A2I3TEQ9
db: uniprot

Aph-1
type: Protein
entity reference: Aph-1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Histone acetyltransferase KAT5
type: ProteinReference
xref: uniprot Q92993 722
xref: PTHR10615:SF183
organism: Homo sapiens

Neurogenic locus Notch protein
type: ProteinReference
xref: PTHR22804:SF47
xref: uniprot P07207 448
organism: Drosophila melanogaster

Segment polarity protein dishevelled homolog DVL-3
type: ProteinReference
xref: uniprot Q92997 700
xref: PTHR10878:SF6
organism: Homo sapiens

Neuroendocrine convertase 2
type: ProteinReference
xref: uniprot F6Q5F4 961
organism: Bos taurus

Actin-5C
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P84185 275
organism: Anopheles gambiae

PTHR11937:SF468
type: RelationshipXref
id: PTHR11937:SF468
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF464
type: RelationshipXref
id: PTHR11937:SF464
db: PANTHER Family
relationship type: By Homology

Protein Wnt-16
type: ProteinReference
xref: uniprot Q9UBV4 883
xref: PTHR12027:SF70
organism: Homo sapiens

uniprot Q9NZ42 929
type: UnificationXref
id: Q9NZ42
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot F1MHG3 771
organism: Bos taurus

TRUNCATION_LEFT__LRP-RIGHT__LRP_N_terminal_fragment-_LRP_C_terminal_fragment-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1292
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1293
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1294
left: LRP
interaction type: TRUNCATION
right: LRP N-terminal fragment
right: LRP C-terminal fragment

Transient receptor potential cation channel subfamily C member 3
type: ProteinReference
xref: PTHR10117:SF8
xref: uniprot F6XTG1 479
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MHG1 574
xref: PTHR10201:SF25
organism: Bos taurus

Catenin beta-1
type: ProteinReference
xref: uniprot P35222 945
xref: PTHR45976:SF4
organism: Homo sapiens

uniprot A4D7S0 741
type: UnificationXref
id: A4D7S0
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A7SEB1 115
xref: PTHR11937:SF473
organism: Nematostella vectensis

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 7

PTHR11309:SF90
type: RelationshipXref
id: PTHR11309:SF90
db: PANTHER Family
relationship type: By Homology

uniprot F1N3C4 525
type: UnificationXref
id: F1N3C4
db: uniprot

uniprot Q8JHE9 1043
type: UnificationXref
id: Q8JHE9
db: uniprot

PTHR12889:SF0
type: RelationshipXref
id: PTHR12889:SF0
db: PANTHER Family
relationship type: By Homology

PTHR12889:SF1
type: RelationshipXref
id: PTHR12889:SF1
db: PANTHER Family
relationship type: By Homology

uniprot C3YZ17 751
type: UnificationXref
id: C3YZ17
db: uniprot

uniprot P97887 551
type: UnificationXref
id: P97887
db: uniprot

uniprot Q67G20 299
type: UnificationXref
id: Q67G20
db: uniprot

PTHR12889:SF3
type: RelationshipXref
id: PTHR12889:SF3
db: PANTHER Family
relationship type: By Homology

PTHR23103:SF7
type: RelationshipXref
id: PTHR23103:SF7
db: PANTHER Family
relationship type: By Homology

Cytoplasmatic actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot E9FZ00 169
organism: Daphnia pulex

PARTICIPANT STOICHIOMETRY r33 1254
type: Stoichiometry
physical entity: a153_degraded
stoichiometric coefficient: 1.0

PTHR12889:SF5
type: RelationshipXref
id: PTHR12889:SF5
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF99
type: RelationshipXref
id: PTHR11309:SF99
db: PANTHER Family
relationship type: By Homology

DISSOCIATION_LEFT__Complex__Nectin_1alpha_Afadin__alphacatenin_actin__beta_catenin_gammacatenin__E_cadherin_-RIGHT__gammacatenin-_actin-_E_cadherin-_alphacatenin-_beta_catenin-_Afadin-_r64
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1263
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1259
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1257
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1258
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1262
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1260
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1261
left: Complex (Nectin 1alpha/Afadin/ alphacatenin/actin/ beta-catenin/gammacatenin/ E-cadherin)
interaction type: DISSOCIATION
right: Afadin
right: gammacatenin
right: E-cadherin
right: beta-catenin
right: alphacatenin
right: actin

PARTICIPANT STOICHIOMETRY r33 1253
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

C99
type: ProteinReference
xref: P00111
standard name: Carboxy-terminal 99 amino acids of amyloid precursor protein
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.C99
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta A4 protein
member entity reference: Amyloid-beta precursor protein

uniprot A0A3Q1MTU2 438
type: UnificationXref
id: A0A3Q1MTU2
db: uniprot

uniprot C3XYW6 749
type: UnificationXref
id: C3XYW6
db: uniprot

NICD
type: ProteinReference
xref: P00122
standard name: Notch intracellular domain
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.NICD
comment: ENTITY_REFERENCE_NOTES=Long Name: Notch intracellular domain Synonym: Synonym not specified Accession: P00122
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Notch 4
member entity reference: Notch 3
member entity reference: Neurogenic locus Notch protein
member entity reference: Notch 1
member entity reference: NOTCH3 isoform 1
member entity reference: NOTCH1 isoform 1

Gamma-secretase subunit Aph-1b
type: ProteinReference
xref: PTHR12889:SF5
xref: uniprot Q8JHE9 1043
organism: Danio rerio

Nectin 1alpha intracellular fragment
type: Protein
entity reference: Nectin 1alpha intracellular fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Transcription factor 7-like 1
type: ProteinReference
xref: uniprot Q9Z1J1 909
xref: PTHR10373:SF25
organism: Mus musculus

PTHR11937:SF477
type: RelationshipXref
id: PTHR11937:SF477
db: PANTHER Family
relationship type: By Homology

LRP N-terminal fragment
type: Protein
entity reference: LRP N-terminal fragment
comment: SPECIES_TYPE=PROTEIN

PTHR11937:SF473
type: RelationshipXref
id: PTHR11937:SF473
db: PANTHER Family
relationship type: By Homology

APP s24 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: APP
stoichiometric coefficient: 1.0

Protein Wnt-11b-1
type: ProteinReference
xref: PTHR12027:SF34
xref: uniprot Q66II0 867
organism: Xenopus tropicalis

uniprot F1MN70 772
type: UnificationXref
id: F1MN70
db: uniprot

PTHR11937:SF474
type: RelationshipXref
id: PTHR11937:SF474
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YP58 156
xref: PTHR11937:SF468
organism: Branchiostoma floridae

uniprot Q8GUM5 337
type: UnificationXref
id: Q8GUM5
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7SEA7 114
organism: Nematostella vectensis

PTHR11937:SF471
type: RelationshipXref
id: PTHR11937:SF471
db: PANTHER Family
relationship type: By Homology

uniprot O00144 397
type: UnificationXref
id: O00144
db: uniprot

PTHR11937:SF470
type: RelationshipXref
id: PTHR11937:SF470
db: PANTHER Family
relationship type: By Homology

uniprot Q7PXZ8 312
type: UnificationXref
id: Q7PXZ8
db: uniprot

Transcription factor 7-like 1-A
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot Q9YHE8 908
organism: Danio rerio

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot E2RH98 768
organism: Canis lupus familiaris

Lymphoid enhancer-binding factor 1
type: ProteinReference
xref: uniprot Q9UJU2 906
xref: PTHR10373:SF11
organism: Homo sapiens

Short transient receptor potential channel 1
type: ProteinReference
xref: PTHR10117:SF56
xref: uniprot P48995 497
organism: Homo sapiens

uniprot P49769 548
type: UnificationXref
id: P49769
db: uniprot

Transient-receptor-potential-like protein
type: ProteinReference
xref: PTHR10117:SF47
xref: uniprot P48994 496
organism: Drosophila melanogaster

beta catenin s131 a164 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot Q9UJU2 906
type: UnificationXref
id: Q9UJU2
db: uniprot

uniprot A2ARV4 47
type: UnificationXref
id: A2ARV4
db: uniprot

uniprot Q9H1J7 877
type: UnificationXref
id: Q9H1J7
db: uniprot

uniprot P22894 632
type: UnificationXref
id: P22894
db: uniprot

uniprot F7HBK3 705
type: UnificationXref
id: F7HBK3
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__APP_Fe65_-RIGHT__Complex__C99_Fe65_-_APPbeta-_r51
controller: BACE-1

Dibasic-processing endoprotease
type: ProteinReference
xref: uniprot Q09175 991
organism: Schizosaccharomyces pombe

uniprot H2RAM0 811
type: UnificationXref
id: H2RAM0
db: uniprot

uniprot B0S5E7 360
type: UnificationXref
id: B0S5E7
db: uniprot

PARTICIPANT STOICHIOMETRY r15 1207
type: Stoichiometry
physical entity: Erb-B4 N-terminal fragment
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10373:SF11
xref: uniprot A0A3Q3B1W2 892
organism: Gallus gallus

uniprot D3ZND6 757
type: UnificationXref
id: D3ZND6
db: uniprot

uniprot P63261 258
type: UnificationXref
id: P63261
db: uniprot

PARTICIPANT STOICHIOMETRY r15 1205
type: Stoichiometry
physical entity: Erb-B4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 1206
type: Stoichiometry
physical entity: Erb-B4 C-terminal fragment
stoichiometric coefficient: 1.0

uniprot B8JIQ1 1050
type: UnificationXref
id: B8JIQ1
db: uniprot

uniprot P30432 987
type: UnificationXref
id: P30432
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FWA9 528
organism: Macaca mulatta

Presenilin-like protein At1g08700
type: ProteinReference
xref: PTHR10202:SF26
xref: uniprot O64668 545
organism: Arabidopsis thaliana

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot O57328 398
organism: Gallus gallus

uniprot P26051 463
type: UnificationXref
id: P26051
db: uniprot

TRUNCATION
type: InteractionVocabulary

uniprot D3ZF63 755
type: UnificationXref
id: D3ZF63
db: uniprot

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: PTHR24270:SF12
xref: uniprot G7N677 65
organism: Macaca mulatta

uniprot F7A2E1 538
type: UnificationXref
id: F7A2E1
db: uniprot

uniprot F1LQF7 471
type: UnificationXref
id: F1LQF7
db: uniprot

uniprot F6ZBJ4 897
type: UnificationXref
id: F6ZBJ4
db: uniprot

Tripartite motif-containing protein 2
type: ProteinReference
xref: uniprot A4IF63 666
organism: Bos taurus

STATE_TRANSITION_LEFT__Capacitative_calcium_channels-RIGHT__Capacitative_calcium_channels-_re56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re56 1187
participant stoichiometry: PARTICIPANT STOICHIOMETRY re56 1188
left: Capacitative calcium channels
interaction type: STATE_TRANSITION
right: Capacitative calcium channels

Transient receptor potential cation channel subfamily C member 7
type: ProteinReference
xref: uniprot F1NYQ1 473
xref: PTHR10117:SF9
organism: Gallus gallus

Presenilin
type: Protein
entity reference: Presenilin
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Erb-B4 C-terminal fragment
type: ProteinReference
xref: P00163
comment: ENTITY_REFERENCE_NOTES=Long Name: Erb-B4 C-terminal fragment Synonym: Synonym not specified Accession: P00163
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Erb-B4_br_C-terminal_br_fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: Receptor protein-tyrosine kinase
member entity reference: Receptor tyrosine-protein kinase erbB-4

Dsh
type: ProteinReference
xref: P00132
standard name: Dishevelled
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Dishevelled Synonym: Synonym not specified Accession: P00132
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Dsh
member entity reference: Segment polarity protein dishevelled homolog DVL-3
member entity reference: Segment polarity protein dishevelled homolog DVL-1
member entity reference: Uncharacterized protein
member entity reference: Segment polarity protein dishevelled homolog DVL-2
member entity reference: Dishevelled segment polarity protein 2
member entity reference: DVL3 isoform 1
member entity reference: Dishevelled segment polarity protein 3
member entity reference: Dishevelled segment polarity protein 3a
member entity reference: Dishevelled segment polarity protein 1
member entity reference: DVL2 isoform 1

uniprot P08253 629
type: UnificationXref
id: P08253
db: uniprot

uniprot Q99466 455
type: UnificationXref
id: Q99466
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Erb_B4-RIGHT__Erb_B4_C_terminal_fragment-_Erb_B4_N_terminal_fragment-_r15
controller: TACE

Frizzled class receptor 9b
type: ProteinReference
xref: PTHR11309:SF79
xref: uniprot B0S5E7 360
organism: Danio rerio

uniprot Q61527 92
type: UnificationXref
id: Q61527
db: uniprot

FZD10 isoform 2
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot H2Q772 390
organism: Pan troglodytes

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 172

uniprot O18767 619
type: UnificationXref
id: O18767
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot C3ZMR2 160
organism: Branchiostoma floridae

Matrix metalloproteinase-B
type: ProteinReference
xref: PTHR10201:SF239
xref: uniprot O44836 620
organism: Caenorhabditis elegans

STATE_TRANSITION_LEFT__Ire_1-RIGHT__Ire_1-_r37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1248
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1249
left: Ire-1
interaction type: STATE_TRANSITION
right: Ire-1

alphacatenin
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Tripartite motif containing 3
type: ProteinReference
xref: uniprot E2QVW6 669
organism: Canis lupus familiaris

uniprot Q6TYS2 307
type: UnificationXref
id: Q6TYS2
db: uniprot

Matrix metallopeptidase 20
type: ProteinReference
xref: uniprot D3ZXD9 571
xref: PTHR10201:SF125
organism: Rattus norvegicus

uniprot Q9QW30 456
type: UnificationXref
id: Q9QW30
db: uniprot

ncbitaxon 3055 119
type: UnificationXref
id: 3055
db: ncbitaxon

Frizzled class receptor 5
type: ProteinReference
xref: PTHR11309:SF139
xref: uniprot B3DIG4 362
organism: Danio rerio

uniprot F1A175 174
type: UnificationXref
id: F1A175
db: uniprot

Presenilin
type: Protein
entity reference: Presenilin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9YGX6 886
type: UnificationXref
id: Q9YGX6
db: uniprot

uniprot P56817 1027
type: UnificationXref
id: P56817
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24270:SF5
xref: uniprot F6SZP3 57
organism: Macaca mulatta

uniprot F6UA63 189
type: UnificationXref
id: F6UA63
db: uniprot

uniprot O60882 622
type: UnificationXref
id: O60882
db: uniprot

Matrix metalloproteinase-15
type: ProteinReference
xref: PTHR10201:SF25
xref: uniprot O54732 621
organism: Mus musculus

uniprot A0A1D5QFN4 563
type: UnificationXref
id: A0A1D5QFN4
db: uniprot

Neuroendocrine convertase 2
type: ProteinReference
xref: uniprot P16519 977
organism: Homo sapiens

uniprot A7SEB1 115
type: UnificationXref
id: A7SEB1
db: uniprot

Afadin s12 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Afadin
stoichiometric coefficient: 1.0

Fe65 s27 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

Transcription factor cbf11
type: ProteinReference
xref: uniprot O74954 1016
organism: Schizosaccharomyces pombe

Erb-B4 intracellular fragment
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Notch extracellular fragment s43 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Notch extracellular fragment
stoichiometric coefficient: 1.0

Protein kinase gsk31
type: ProteinReference
xref: uniprot Q9URT9 1074
organism: Schizosaccharomyces pombe

uniprot H2QA34 970
type: UnificationXref
id: H2QA34
db: uniprot

Glycogen synthase kinase-3
type: ProteinReference
xref: uniprot Q9U2Q9 1073
organism: Caenorhabditis elegans

Beta-secretase 2
type: ProteinReference
xref: uniprot Q9Y5Z0 1030
organism: Homo sapiens

Fe65 s35 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

Notch
type: Protein
entity reference: Notch
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: PTHR10878:SF5
xref: uniprot O14640 694
organism: Homo sapiens

Protein CBG02167
type: ProteinReference
xref: uniprot A8WS37 123
xref: PTHR11937:SF470
organism: Caenorhabditis briggsae

ncbitaxon 7668 230
type: UnificationXref
id: 7668
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__LRP_C_terminal_fragment-RIGHT__LRP_transmembrane_fragment-_LRP_intracellular_fragment-_r24
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

Segment polarity protein dishevelled homolog DVL-2
type: ProteinReference
xref: uniprot O14641 695
xref: PTHR10878:SF8
organism: Homo sapiens

Tripartite motif-containing protein 2
type: ProteinReference
xref: uniprot Q9ESN6 678
organism: Mus musculus

uniprot Q15223 706
type: UnificationXref
id: Q15223
db: uniprot

uniprot F6SLU9 779
type: UnificationXref
id: F6SLU9
db: uniprot

uniprot Q39011 1064
type: UnificationXref
id: Q39011
db: uniprot

uniprot O44836 620
type: UnificationXref
id: O44836
db: uniprot

PARTICIPANT STOICHIOMETRY r43 1233
type: Stoichiometry
physical entity: BACE-1 pro-domain
stoichiometric coefficient: 1.0

Matrix metallopeptidase 25
type: ProteinReference
xref: uniprot A0A2I3SF35 567
xref: PTHR10201:SF142
organism: Pan troglodytes

uniprot H2R2U1 943
type: UnificationXref
id: H2R2U1
db: uniprot

Short transient receptor potential channel 4
type: ProteinReference
xref: PTHR10117:SF25
xref: uniprot Q9QUQ5 506
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r43 1231
type: Stoichiometry
physical entity: Pro-BACE-1
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF76
xref: uniprot A0A0G2K6Q8 730
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r43 1232
type: Stoichiometry
physical entity: BACE-1
stoichiometric coefficient: 1.0

E-cadherin N-terminal fragment
type: Protein
entity reference: E-cadherin N-terminal fragment
comment: SPECIES_TYPE=PROTEIN

CD44
type: ProteinReference
xref: P00145
standard name: Cell surface glycoprotein 44
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.CD44
comment: ENTITY_REFERENCE_NOTES=Long Name: Cell surface glycoprotein 44 Synonym: Synonym not specified Accession: P00145
member entity reference: CD44 antigen
member entity reference: CD44 molecule
member entity reference: Phagocytic glycoprotein I

uniprot F6WHM2 783
type: UnificationXref
id: F6WHM2
db: uniprot

Aph-1 homolog A, gamma-secretase subunit
type: ProteinReference
xref: PTHR12889:SF3
xref: uniprot A0A3Q1MBH7 1032
organism: Bos taurus

Protein Wnt-16
type: ProteinReference
xref: uniprot Q9QYS1 881
xref: PTHR12027:SF70
organism: Mus musculus

Capacitative calcium channels
type: Protein
entity reference: Capacitative calcium channels
feature: ACTIVE 517
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

uniprot F7GH85 795
type: UnificationXref
id: F7GH85
db: uniprot

uniprot B8JMI2 682
type: UnificationXref
id: B8JMI2
db: uniprot

Protein CBG02161
type: ProteinReference
xref: uniprot A8WS32 120
xref: PTHR11937:SF471
organism: Caenorhabditis briggsae

Recombination signal binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: uniprot F6ULE6 1009
xref: PTHR10665:SF3
organism: Ornithorhynchus anatinus

Protein CBG02162
type: ProteinReference
xref: PTHR11937:SF471
xref: uniprot A8WS33 122
organism: Caenorhabditis briggsae

uniprot E1BDG5 763
type: UnificationXref
id: E1BDG5
db: uniprot

uniprot D4A3W9 760
type: UnificationXref
id: D4A3W9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZHN2 158
xref: PTHR11937:SF446
organism: Branchiostoma floridae

Catenin, beta 2
type: ProteinReference
xref: uniprot E7FC99 938
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZHN4 159
xref: PTHR11937:SF446
organism: Branchiostoma floridae

uniprot F7G632 965
type: UnificationXref
id: F7G632
db: uniprot

uniprot C3Z2P0 752
type: UnificationXref
id: C3Z2P0
db: uniprot

uniprot G3V742 607
type: UnificationXref
id: G3V742
db: uniprot

LRP intracellular fragment
type: Protein
entity reference: LRP intracellular fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa9 1166
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TRUNCATION_LEFT__LRP_C_terminal_fragment-RIGHT__LRP_transmembrane_fragment-_LRP_intracellular_fragment-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1289
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1291
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1290
left: LRP C-terminal fragment
interaction type: TRUNCATION
right: LRP transmembrane fragment
right: LRP intracellular fragment

uniprot A0A1D5QA06 466
type: UnificationXref
id: A0A1D5QA06
db: uniprot

uniprot E2REE0 956
type: UnificationXref
id: E2REE0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F6RFW8 184
organism: Monodelphis domestica

ncbitaxon 13616 56
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot P52166 550
type: UnificationXref
id: P52166
db: uniprot

uniprot Q28IC7 858
type: UnificationXref
id: Q28IC7
db: uniprot

uniprot A0A1D6UPT7 708
type: UnificationXref
id: A0A1D6UPT7
db: uniprot

CD44 C-terminal fragment
type: Protein
entity reference: CD44 C-terminal fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Recombining binding protein suppressor of hairless
type: ProteinReference
xref: PTHR10665:SF3
xref: uniprot Q06330 1019
organism: Homo sapiens

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 327

Complex (Wnt/Frizzled)
type: Complex
component stoichiometry: Frizzled s78 sa44 STOICHIOMETRY ID COMPLEX
component stoichiometry: Wnt s77 sa43 STOICHIOMETRY ID COMPLEX
component: Frizzled
component: Wnt
feature: COMPLEX BINDING FEATURE s258 a247 1173
feature: COMPLEX BINDING FEATURE s258 a247 1175
cellular location: cytosol

Frizzled-5
type: ProteinReference
xref: PTHR11309:SF136
xref: uniprot Q8CHL0 419
organism: Rattus norvegicus

beta catenin s61 sa22 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PTHR12027:SF7
type: RelationshipXref
id: PTHR12027:SF7
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF34
type: RelationshipXref
id: PTHR11309:SF34
db: PANTHER Family
relationship type: By Homology

Amyloid beta precursor protein binding family B member 1
type: ProteinReference
xref: uniprot A0A2I3SB38 518
xref: PTHR14058:SF5
organism: Pan troglodytes

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot Q3ZC07 284
organism: Bos taurus

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot Q9UP38 433
organism: Homo sapiens

uniprot P09615 827
type: UnificationXref
id: P09615
db: uniprot

uniprot F7CQF2 60
type: UnificationXref
id: F7CQF2
db: uniprot

PARTICIPANT STOICHIOMETRY r79 1200
type: Stoichiometry
physical entity: Complex (LRP intracellular fragment/Fe65)
stoichiometric coefficient: 1.0

uniprot Q8BVF7 1041
type: UnificationXref
id: Q8BVF7
db: uniprot

Afadin
type: Protein
entity reference: Afadin
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa17 1148
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRUNCATION_LEFT__Complex__Nectin_1alpha_Afadin__alphacatenin_actin__beta_catenin_gammacatenin__E_cadherin_-RIGHT__Nectin_1alpha_C_terminal_fragment-_Nectin_1alpha_N_terminal_fragment-_r61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1271
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1270
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1269
left: Complex (Nectin 1alpha/Afadin/ alphacatenin/actin/ beta-catenin/gammacatenin/ E-cadherin)
interaction type: TRUNCATION
right: Nectin 1alpha C-terminal fragment
right: Nectin 1alpha N-terminal fragment

PARTICIPANT STOICHIOMETRY r79 1201
type: Stoichiometry
physical entity: Complex (LRP intracellular fragment/Fe65)
stoichiometric coefficient: 1.0

uniprot F6TUR3 187
type: UnificationXref
id: F6TUR3
db: uniprot

Protein Wnt-3a
type: ProteinReference
xref: uniprot P27467 836
xref: PTHR12027:SF88
organism: Mus musculus

BACE-1 pro-domain
type: ProteinReference
xref: P00178
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.BACE-1_br_pro-domain
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: BACE-1 pro-domain Synonym: Synonym not specified Accession: P00178
member entity reference: Beta-secretase 1
member entity reference: Uncharacterized protein
member entity reference: Beta-secretase 2
member entity reference: BACE2 isoform 3

Short transient receptor potential channel 6
type: ProteinReference
xref: uniprot Q9Y210 516
xref: PTHR10117:SF7
organism: Homo sapiens

PTHR11309:SF31
type: RelationshipXref
id: PTHR11309:SF31
db: PANTHER Family
relationship type: By Homology

uniprot Q9Z1K9 919
type: UnificationXref
id: Q9Z1K9
db: uniprot

Frizzled class receptor 9
type: ProteinReference
xref: PTHR11309:SF79
xref: uniprot E2RAF3 366
organism: Canis lupus familiaris

actin s49 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: actin
stoichiometric coefficient: 1.0

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot P49841 1060
xref: PTHR24057:SF8
organism: Homo sapiens

Fe65 s8 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

uniprot A7MB62 109
type: UnificationXref
id: A7MB62
db: uniprot

Histone acetyltransferase KAT5
type: ProteinReference
xref: uniprot Q8CHK4 721
xref: PTHR10615:SF183
organism: Mus musculus

PTHR11309:SF22
type: RelationshipXref
id: PTHR11309:SF22
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF23
type: RelationshipXref
id: PTHR11309:SF23
db: PANTHER Family
relationship type: By Homology

uniprot F1QGH7 939
type: UnificationXref
id: F1QGH7
db: uniprot

Presenilin N terminal fragment s84 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin N-terminal fragment
stoichiometric coefficient: 1.0

uniprot F7APL6 526
type: UnificationXref
id: F7APL6
db: uniprot

uniprot F6UKT0 712
type: UnificationXref
id: F6UKT0
db: uniprot

Prolow-density lipoprotein receptor-related protein 1
type: ProteinReference
xref: PTHR24270:SF23
xref: uniprot Q07954 79
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DIB7 197
xref: PTHR11937:SF414
organism: Monodelphis domestica

72 kDa type IV collagenase
type: ProteinReference
xref: PTHR10201:SF29
xref: uniprot P08253 629
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR10201:SF29
xref: uniprot F7EVX9 598
organism: Monodelphis domestica

uniprot Q6P8G3 306
type: UnificationXref
id: Q6P8G3
db: uniprot

uniprot P0C540 221
type: UnificationXref
id: P0C540
db: uniprot

Beta-secretase 1
type: ProteinReference
xref: uniprot Q2HJ40 1029
xref: PTHR47965:SF69
organism: Bos taurus

uniprot Q9NZR2 84
type: UnificationXref
id: Q9NZR2
db: uniprot

PTHR11937:SF176
type: RelationshipXref
id: PTHR11937:SF176
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3SYK4 46
type: UnificationXref
id: A0A2I3SYK4
db: uniprot

uniprot O64668 545
type: UnificationXref
id: O64668
db: uniprot

uniprot Q66II0 867
type: UnificationXref
id: Q66II0
db: uniprot

MMP2 isoform 1
type: ProteinReference
xref: PTHR10201:SF29
xref: uniprot A0A2I3TEQ9 569
organism: Pan troglodytes

Erb-B4
type: Protein
entity reference: Erb-B4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

APP
type: Protein
entity reference: APP
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa30 1170
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 284591 327
type: UnificationXref
id: 284591
db: ncbitaxon

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot D3ZRW5 758
organism: Rattus norvegicus

uniprot P93738 278
type: UnificationXref
id: P93738
db: uniprot

E-cadherin
type: Protein
entity reference: E-cadherin
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa11 1096
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9W7C0 907
type: UnificationXref
id: Q9W7C0
db: uniprot

uniprot Q6DHS1 300
type: UnificationXref
id: Q6DHS1
db: uniprot

uniprot P53492 240
type: UnificationXref
id: P53492
db: uniprot

uniprot P10981 224
type: UnificationXref
id: P10981
db: uniprot

actin, muscle
type: ProteinReference
xref: uniprot F6SDC9 186
organism: Ciona intestinalis

uniprot A8WV10 744
type: UnificationXref
id: A8WV10
db: uniprot

uniprot A9TZ58 132
type: UnificationXref
id: A9TZ58
db: uniprot

NICD s262 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NICD
stoichiometric coefficient: 1.0

Presenilin-1
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot P97887 551
organism: Rattus norvegicus

uniprot Q91000 999
type: UnificationXref
id: Q91000
db: uniprot

PTHR11937:SF168
type: RelationshipXref
id: PTHR11937:SF168
db: PANTHER Family
relationship type: By Homology

Low-density lipoprotein receptor-related protein 4
type: ProteinReference
xref: PTHR24270:SF5
xref: uniprot Q9QYP1 85
organism: Rattus norvegicus

beta catenin s87 a103 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Ire-1 N-terminal fragment
type: ProteinReference
xref: P00110
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Ire-1_br_N-terminal_br_fragment
comment: ENTITY_REFERENCE_NOTES=Long Name: Ire-1 N-terminal fragment Synonym: Synonym not specified Accession: P00110
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE1
member entity reference: Endoplasmic reticulum to nucleus-signaling 1
member entity reference: Endoplasmic reticulum to nucleus signaling 2
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE1a
member entity reference: Endoplasmic reticulum to nucleus signaling 1
member entity reference: Endoplasmic reticulum (ER) to nucleus signalling 2 (Predicted)
member entity reference: Serine/threonine-protein kinase ppk4
member entity reference: ERN1 isoform 4
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE1b
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE2
member entity reference: Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like

uniprot Q99N78 503
type: UnificationXref
id: Q99N78
db: uniprot

PTHR11309:SF47
type: RelationshipXref
id: PTHR11309:SF47
db: PANTHER Family
relationship type: By Homology

Protein Wnt-10a
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot P43446 843
organism: Danio rerio

uniprot H2QR92 972
type: UnificationXref
id: H2QR92
db: uniprot

uniprot Q65XH8 298
type: UnificationXref
id: Q65XH8
db: uniprot

PTHR11937:SF162
type: RelationshipXref
id: PTHR11937:SF162
db: PANTHER Family
relationship type: By Homology

PTHR24416:SF90
type: RelationshipXref
id: PTHR24416:SF90
db: PANTHER Family
relationship type: By Homology

By Homology
type: RelationshipTypeVocabulary

eco ECO:0000304 38
type: UnificationXref
id: ECO:0000304
db: eco

uniprot F7AIP6 898
type: UnificationXref
id: F7AIP6
db: uniprot

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 4

Matrix metalloproteinase-14
type: ProteinReference
xref: uniprot Q10739 649
xref: PTHR10201:SF24
organism: Rattus norvegicus

Matrilysin
type: ProteinReference
xref: uniprot Q10738 648
xref: PTHR10201:SF143
organism: Mus musculus

PTHR22804:SF52
type: RelationshipXref
id: PTHR22804:SF52
db: PANTHER Family
relationship type: By Homology

Frizzled 8a protein
type: ProteinReference
xref: uniprot Q9YI00 436
xref: PTHR11309:SF140
organism: Danio rerio

RBPJ isoform 12
type: ProteinReference
xref: uniprot A0A2J8NVW7 1003
xref: PTHR10665:SF3
organism: Pan troglodytes

uniprot Q9Z2E3 35
type: UnificationXref
id: Q9Z2E3
db: uniprot

uniprot F7CDC6 383
type: UnificationXref
id: F7CDC6
db: uniprot

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot A0A2I3RVR8 44
xref: PTHR46513:SF16
organism: Pan troglodytes

uniprot A0A2J8N8E6 356
type: UnificationXref
id: A0A2J8N8E6
db: uniprot

uniprot A0A2I3TIR0 520
type: UnificationXref
id: A0A2I3TIR0
db: uniprot

uniprot Q7ZVI7 316
type: UnificationXref
id: Q7ZVI7
db: uniprot

PTHR11937:SF154
type: RelationshipXref
id: PTHR11937:SF154
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF75
type: RelationshipXref
id: PTHR11309:SF75
db: PANTHER Family
relationship type: By Homology

LRP C-terminal fragment
type: Protein
entity reference: LRP C-terminal fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR11937:SF150
type: RelationshipXref
id: PTHR11937:SF150
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF79
type: RelationshipXref
id: PTHR11309:SF79
db: PANTHER Family
relationship type: By Homology

TRUNCATION_LEFT__Complex__C99_Fe65_-RIGHT__Complex__AICD_Fe65_-_Abeta-_r50
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 1308
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 1307
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 1306
left: Complex (C99/Fe65)
interaction type: TRUNCATION
right: Abeta
right: Complex (AICD/Fe65)

uniprot D3ZQG6 668
type: UnificationXref
id: D3ZQG6
db: uniprot

TRUNCATION_LEFT__Ire_1-RIGHT__Ire_1_N_terminal_fragment-_Ire_1_C_terminal_fragment-_r38
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1246
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1245
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 1247
left: Ire-1
interaction type: TRUNCATION
right: Ire-1 C-terminal fragment
right: Ire-1 N-terminal fragment

uniprot P49337 847
type: UnificationXref
id: P49337
db: uniprot

Nectin 1alpha transmembrane fragment
type: Protein
entity reference: Nectin 1alpha transmembrane fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G8Z6 601
xref: PTHR10201:SF26
organism: Monodelphis domestica

Nicastrin
type: Protein
entity reference: Nicastrin
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

uniprot F2Z4N7 180
type: UnificationXref
id: F2Z4N7
db: uniprot

ncbitaxon 6669 167
type: UnificationXref
id: 6669
db: ncbitaxon

Neutrophil collagenase
type: ProteinReference
xref: uniprot O70138 623
xref: PTHR10201:SF137
organism: Mus musculus

uniprot P38615 1057
type: UnificationXref
id: P38615
db: uniprot

uniprot P61161 251
type: UnificationXref
id: P61161
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 3

PTHR11937:SF149
type: RelationshipXref
id: PTHR11937:SF149
db: PANTHER Family
relationship type: By Homology

TRUNCATION
type: RelationshipTypeVocabulary

Pen-2
type: Protein
entity reference: Pen-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa47 1126
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

AGAP007207-PA
type: ProteinReference
xref: PTHR24026:SF108
xref: uniprot A0NBC9 351
organism: Anopheles gambiae

uniprot F7A0Y4 596
type: UnificationXref
id: F7A0Y4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H767 967
organism: Macaca mulatta

uniprot P28840 982
type: UnificationXref
id: P28840
db: uniprot

Protein Wnt-11
type: ProteinReference
xref: PTHR12027:SF7
xref: uniprot O96014 823
organism: Homo sapiens

uniprot Q9Y5Z0 1030
type: UnificationXref
id: Q9Y5Z0
db: uniprot

uniprot A0A1D5QTJ7 565
type: UnificationXref
id: A0A1D5QTJ7
db: uniprot

Matrilysin
type: ProteinReference
xref: uniprot P50280 640
xref: PTHR10201:SF143
organism: Rattus norvegicus

Matrix metalloproteinase-14
type: ProteinReference
xref: PTHR10201:SF24
xref: uniprot P50281 641
organism: Homo sapiens

Matrix metalloproteinase-9
type: ProteinReference
xref: uniprot P50282 642
xref: PTHR10201:SF30
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FDA8 672
organism: Monodelphis domestica

uniprot Q61090 413
type: UnificationXref
id: Q61090
db: uniprot

ncbitaxon 9544 16
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot G3V928 64
type: UnificationXref
id: G3V928
db: uniprot

Recombining binding protein suppressor of hairless-like protein
type: ProteinReference
xref: uniprot Q9UBG7 1021
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Notch-RIGHT__Notch_C_terminal_fragment-_Notch_N_terminal_fragment-_r1
controller: Furin

uniprot Q78EH2 997
type: UnificationXref
id: Q78EH2
db: uniprot

uniprot F6PJR9 776
type: UnificationXref
id: F6PJR9
db: uniprot

beta catenin s46 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

Ser beta catenin s46 sa12 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Ser
feature location: Ser beta catenin s46 sa12 rs1 Ser
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=Ser

uniprot A8WS37 123
type: UnificationXref
id: A8WS37
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y0D3 950
organism: Strongylocentrotus purpuratus

PARTICIPANT STOICHIOMETRY r1 1223
type: Stoichiometry
physical entity: Notch
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 1225
type: Stoichiometry
physical entity: Notch N-terminal fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 1224
type: Stoichiometry
physical entity: Notch C-terminal fragment
stoichiometric coefficient: 1.0

uniprot P28841 983
type: UnificationXref
id: P28841
db: uniprot

uniprot H2R9Y7 491
type: UnificationXref
id: H2R9Y7
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot C3YYJ8 750
organism: Branchiostoma floridae

uniprot P03956 628
type: UnificationXref
id: P03956
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 61

uniprot D4A3K6 759
type: UnificationXref
id: D4A3K6
db: uniprot

Notch N-terminal fragment
type: Protein
entity reference: Notch N-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa3 1080
comment: SPECIES_TYPE=PROTEIN

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: uniprot P68033 264
xref: PTHR11937:SF176
organism: Mus musculus

uniprot O18840 211
type: UnificationXref
id: O18840
db: uniprot

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68032 263
organism: Homo sapiens

uniprot Q90X07 556
type: UnificationXref
id: Q90X07
db: uniprot

uniprot O96014 823
type: UnificationXref
id: O96014
db: uniprot

ncbitaxon 214684 293
type: UnificationXref
id: 214684
db: ncbitaxon

uniprot P0DM41 222
type: UnificationXref
id: P0DM41
db: uniprot

uniprot H3FCG4 209
type: UnificationXref
id: H3FCG4
db: uniprot

uniprot B0S6S2 361
type: UnificationXref
id: B0S6S2
db: uniprot

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot Q5G235 923
organism: Bos taurus

Afadin
type: ProteinReference
xref: P00146
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Afadin Synonym: Synonym not specified Accession: P00146
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Afadin
member entity reference: Uncharacterized protein
member entity reference: Afadin
member entity reference: Afadin, adherens junction formation factor

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: uniprot P68035 266
xref: PTHR11937:SF176
organism: Rattus norvegicus

PTHR22804:SF47
type: RelationshipXref
id: PTHR22804:SF47
db: PANTHER Family
relationship type: By Homology

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68034 265
organism: Gallus gallus

Prolow-density lipoprotein receptor-related protein 1
type: ProteinReference
xref: PTHR24270:SF23
xref: uniprot Q91ZX7 82
organism: Mus musculus

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa33 1090
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Amontillado
type: ProteinReference
xref: uniprot Q9VBC7 1000
organism: Drosophila melanogaster

uniprot F6SDC9 186
type: UnificationXref
id: F6SDC9
db: uniprot

uniprot P18499 229
type: UnificationXref
id: P18499
db: uniprot

PTHR22722:SF6
type: RelationshipXref
id: PTHR22722:SF6
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF193
type: RelationshipXref
id: PTHR11937:SF193
db: PANTHER Family
relationship type: By Homology

ncbitaxon 6945 142
type: UnificationXref
id: 6945
db: ncbitaxon

PTHR11937:SF192
type: RelationshipXref
id: PTHR11937:SF192
db: PANTHER Family
relationship type: By Homology

CTNNB1 isoform 2
type: ProteinReference
xref: uniprot H2R2U1 943
xref: PTHR45976:SF4
organism: Pan troglodytes

STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_r32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1255
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1256
left: beta-catenin
interaction type: STATE_TRANSITION
right: beta-catenin

CD44 intracellular fragment
type: ProteinReference
xref: P00121
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.CD44_br_intracellular_br_fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: CD44 intracellular fragment Synonym: Synonym not specified Accession: P00121
member entity reference: CD44 antigen
member entity reference: CD44 molecule
member entity reference: Phagocytic glycoprotein I

uniprot E2QWV4 522
type: UnificationXref
id: E2QWV4
db: uniprot

uniprot F7HG05 911
type: UnificationXref
id: F7HG05
db: uniprot

uniprot F1Q334 894
type: UnificationXref
id: F1Q334
db: uniprot

uniprot F6WBV7 590
type: UnificationXref
id: F6WBV7
db: uniprot

uniprot Q8K3F2 651
type: UnificationXref
id: Q8K3F2
db: uniprot

STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1264
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1265
left: beta-catenin
interaction type: STATE_TRANSITION
right: beta-catenin

PTHR22722:SF5
type: RelationshipXref
id: PTHR22722:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q92870 534
type: UnificationXref
id: Q92870
db: uniprot

uniprot A0A0G2K6H8 1031
type: UnificationXref
id: A0A0G2K6H8
db: uniprot

uniprot P51028 849
type: UnificationXref
id: P51028
db: uniprot

TRUNCATION_LEFT__E_cadherin_C_terminal_fragment-RIGHT__E_cadherin_intracellular_fragment-_E_cadherin_transmembrane_fragment-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1284
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1285
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1283
left: E-cadherin C-terminal fragment
interaction type: TRUNCATION
right: E-cadherin transmembrane fragment
right: E-cadherin intracellular fragment

PTHR45836:SF17
type: RelationshipXref
id: PTHR45836:SF17
db: PANTHER Family
relationship type: By Homology

LDL receptor related protein 6
type: ProteinReference
xref: uniprot F7CQF2 60
xref: PTHR24270:SF12
organism: Ornithorhynchus anatinus

ncbitaxon 237631 95
type: UnificationXref
id: 237631
db: ncbitaxon

PTHR11937:SF184
type: RelationshipXref
id: PTHR11937:SF184
db: PANTHER Family
relationship type: By Homology

uniprot F7F3M6 527
type: UnificationXref
id: F7F3M6
db: uniprot

Complex (CSL/NICD)
type: Complex
component stoichiometry: CSL s5 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: NICD s262 sa6 STOICHIOMETRY ID COMPLEX
component: NICD
component: CSL
feature: COMPLEX BINDING FEATURE s38 a46 1083
feature: ACTIVE 517
feature: COMPLEX BINDING FEATURE s38 a46 1085
cellular location: nucleus

uniprot Q6QI68 924
type: UnificationXref
id: Q6QI68
db: uniprot

Fe65 s29 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

uniprot H2QE24 207
type: UnificationXref
id: H2QE24
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 14

Uncharacterized protein
type: ProteinReference
xref: PTHR10117:SF8
xref: uniprot F7H6Q8 487
organism: Macaca mulatta

PTHR45836:SF12
type: RelationshipXref
id: PTHR45836:SF12
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r71 1239
type: Stoichiometry
physical entity: Dsh
stoichiometric coefficient: 1.0

PTHR45836:SF15
type: RelationshipXref
id: PTHR45836:SF15
db: PANTHER Family
relationship type: By Homology

Presenilin-2
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot Q90ZE4 557
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r71 1238
type: Stoichiometry
physical entity: Dsh
stoichiometric coefficient: 1.0

uniprot A0A2J8MK73 1002
type: UnificationXref
id: A0A2J8MK73
db: uniprot

uniprot Q2IBD1 859
type: UnificationXref
id: Q2IBD1
db: uniprot

TCF7 isoform 6
type: ProteinReference
xref: PTHR10373:SF33
xref: uniprot A0A2I3SWP2 890
organism: Pan troglodytes

Presenilin-1
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot Q9W6T7 559
organism: Danio rerio

uniprot F6SV12 588
type: UnificationXref
id: F6SV12
db: uniprot

Frizzled class receptor 8
type: ProteinReference
xref: uniprot H2R050 393
xref: PTHR11309:SF90
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CQE8 1024
xref: PTHR47965:SF69
organism: Macaca mulatta

uniprot Q9EQY0 32
type: UnificationXref
id: Q9EQY0
db: uniprot

Frizzled class receptor 2
type: ProteinReference
xref: PTHR11309:SF34
xref: uniprot F7DIA9 384
organism: Ornithorhynchus anatinus

uniprot W4Y0P1 1078
type: UnificationXref
id: W4Y0P1
db: uniprot

Disintegrin and metalloproteinase domain-containing protein 17
type: ProteinReference
xref: PTHR45702:SF6
xref: uniprot P78536 917
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR22804:SF52
xref: uniprot F1PS94 441
organism: Canis lupus familiaris

Matrix metalloproteinase-21
type: ProteinReference
xref: uniprot Q8N119 652
xref: PTHR10201:SF147
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r23 1293
type: Stoichiometry
physical entity: LRP N-terminal fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r74 1235
type: Stoichiometry
physical entity: Ire-1 C-terminal fragment
stoichiometric coefficient: 1.0

Frizzled-8
type: ProteinReference
xref: uniprot Q498S8 408
xref: PTHR11309:SF90
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r23 1294
type: Stoichiometry
physical entity: LRP C-terminal fragment
stoichiometric coefficient: 1.0

Nicastrin s79 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Nicastrin
stoichiometric coefficient: 1.0

beta-catenin
type: ProteinReference
xref: P00156
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: beta-catenin Synonym: Synonym not specified Accession: P00156
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC._beta_-catenin
member entity reference: Armadillo segment polarity protein
member entity reference: Catenin beta-1
member entity reference: Catenin, beta 2
member entity reference: Uncharacterized protein
member entity reference: Catenin beta 1
member entity reference: CTNNB1 isoform 2
member entity reference: Catenin (Cadherin-associated protein), beta 1, 88kDa

Ire-1
type: ProteinReference
xref: P00144
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Ire-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Ire-1 Synonym: Synonym not specified Accession: P00144
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE1
member entity reference: Endoplasmic reticulum to nucleus-signaling 1
member entity reference: Endoplasmic reticulum to nucleus signaling 2
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE1a
member entity reference: Endoplasmic reticulum to nucleus signaling 1
member entity reference: Endoplasmic reticulum (ER) to nucleus signalling 2 (Predicted)
member entity reference: Serine/threonine-protein kinase ppk4
member entity reference: ERN1 isoform 4
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE1b
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE2
member entity reference: Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like

PARTICIPANT STOICHIOMETRY r23 1292
type: Stoichiometry
physical entity: LRP
stoichiometric coefficient: 1.0

Os12g0163700 protein
type: ProteinReference
xref: uniprot Q0IPW3 279
xref: PTHR11937:SF474
organism: Oryza sativa

uniprot P53488 238
type: UnificationXref
id: P53488
db: uniprot

Protein CBR-ACT-2
type: ProteinReference
xref: uniprot A8Y4Q9 125
xref: PTHR11937:SF471
organism: Caenorhabditis briggsae

uniprot O88777 546
type: UnificationXref
id: O88777
db: uniprot

PARTICIPANT STOICHIOMETRY r74 1234
type: Stoichiometry
physical entity: Ire-1 C-terminal fragment
stoichiometric coefficient: 1.0

Proprotein convertase subtilisin/kexin type 7
type: ProteinReference
xref: uniprot Q62849 994
organism: Rattus norvegicus

DVL3 isoform 1
type: ProteinReference
xref: uniprot H2QNU7 693
xref: PTHR10878:SF6
organism: Pan troglodytes

uniprot Q9U357 930
type: UnificationXref
id: Q9U357
db: uniprot

uniprot Q91ZX7 82
type: UnificationXref
id: Q91ZX7
db: uniprot

Transcription factor 7-like 1
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot Q9HCS4 903
organism: Homo sapiens

CD44 transmembrane fragment
type: Protein
entity reference: CD44 transmembrane fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P52176 645
type: UnificationXref
id: P52176
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__LRP-RIGHT__LRP_N_terminal_fragment-_LRP_C_terminal_fragment-_r23
controller: Membrane metalloprotease

uniprot A0A3Q1MSZ4 681
type: UnificationXref
id: A0A3Q1MSZ4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot F6ZZG9 193
organism: Monodelphis domestica

Transcription factor 7 like 1
type: ProteinReference
xref: uniprot F7AIP6 898
xref: PTHR10373:SF25
organism: Monodelphis domestica

Protein Wnt
type: ProteinReference
xref: uniprot B0LK22 746
xref: PTHR12027:SF82
organism: Danio rerio

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot Q2IBD1 859
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: uniprot D4A3W9 760
xref: PTHR12027:SF72
organism: Rattus norvegicus

Histone acetyltransferase
type: ProteinReference
xref: uniprot F7DHZ3 714
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot F1MLJ8 369
organism: Bos taurus

Ire-1
type: Protein
entity reference: Ire-1
feature: Ire 1 s136 a168 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Nectin 1alpha intracellular fragment
type: ProteinReference
xref: P00159
comment: ENTITY_REFERENCE_NOTES=Long Name: Nectin 1alpha intracellular fragment Synonym: Synonym not specified Accession: P00159
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Nectin 1_alpha__br_intracellular_br_fragment
member entity reference: Nectin cell adhesion molecule 1
member entity reference: Nectin-1
member entity reference: Uncharacterized protein

uniprot P49339 848
type: UnificationXref
id: P49339
db: uniprot

gammacatenin
type: ProteinReference
xref: P00153
standard name: gamma-catenin
comment: ENTITY_REFERENCE_NOTES=Long Name: gamma-catenin Synonym: Synonym not specified Accession: P00153
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC._gamma_catenin
member entity reference: Junction plakoglobin
member entity reference: Desmoplakin-3

uniprot P18266 1056
type: UnificationXref
id: P18266
db: uniprot

uniprot H2R1L7 1026
type: UnificationXref
id: H2R1L7
db: uniprot

uniprot F7GL73 202
type: UnificationXref
id: F7GL73
db: uniprot

uniprot Q10738 648
type: UnificationXref
id: Q10738
db: uniprot

LRP N-terminal fragment
type: ProteinReference
xref: P00169
comment: ENTITY_REFERENCE_NOTES=Long Name: LRP N-terminal fragment Synonym: Synonym not specified Accession: P00169
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.LRP_br_N-terminal_br_fragment
member entity reference: Low-density lipoprotein receptor-related protein 1B
member entity reference: LDL receptor related protein 1
member entity reference: Low-density lipoprotein receptor-related protein 6
member entity reference: Low-density lipoprotein receptor-related protein
member entity reference: LDL receptor-related protein 1
member entity reference: LDL receptor related protein 3
member entity reference: LDL receptor related protein 6
member entity reference: LDL receptor related protein 4
member entity reference: Low-density lipoprotein receptor-related protein 2
member entity reference: Uncharacterized protein
member entity reference: Low-density lipoprotein receptor-related protein 3
member entity reference: LDL receptor related protein 1B
member entity reference: Low-density lipoprotein receptor-related protein 5
member entity reference: Low-density lipoprotein receptor-related protein 4
member entity reference: Low density lipoprotein receptor-related protein 3
member entity reference: Prolow-density lipoprotein receptor-related protein 1
member entity reference: LDL receptor related protein 2

Endoplasmic reticulum to nucleus signaling 2
type: ProteinReference
xref: uniprot H2QAS4 17
xref: PTHR13954:SF15
organism: Pan troglodytes

MMP24 isoform 1
type: ProteinReference
xref: uniprot H2QK91 617
xref: PTHR10201:SF138
organism: Pan troglodytes

uniprot Q16549 992
type: UnificationXref
id: Q16549
db: uniprot

STATE_TRANSITION_LEFT__GSK_3beta-RIGHT__GSK_3beta-_re55
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re55 1199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re55 1198
left: GSK-3beta
interaction type: STATE_TRANSITION
right: GSK-3beta

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot E1BEN9 764
organism: Bos taurus

uniprot Q5SVQ0 719
type: UnificationXref
id: Q5SVQ0
db: uniprot

uniprot O57328 398
type: UnificationXref
id: O57328
db: uniprot

uniprot P16519 977
type: UnificationXref
id: P16519
db: uniprot

uniprot P19334 495
type: UnificationXref
id: P19334
db: uniprot

PARTICIPANT STOICHIOMETRY r60 1274
type: Stoichiometry
physical entity: Complex (Nectin 1alpha/Afadin/ alphacatenin/actin/ beta-catenin/gammacatenin/ E-cadherin)
stoichiometric coefficient: 1.0

Furin-like protease 2
type: ProteinReference
xref: uniprot P30432 987
xref: PTHR42884:SF23
organism: Drosophila melanogaster

uniprot Q93097 872
type: UnificationXref
id: Q93097
db: uniprot

uniprot F7FWA9 528
type: UnificationXref
id: F7FWA9
db: uniprot

uniprot F6SPF3 586
type: UnificationXref
id: F6SPF3
db: uniprot

PARTICIPANT STOICHIOMETRY r60 1272
type: Stoichiometry
physical entity: Complex (Nectin 1alpha/Afadin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r60 1273
type: Stoichiometry
physical entity: Complex (E-cadherin/beta-catenin/ gammacatenin/alphacatenin/ actin)
stoichiometric coefficient: 1.0

Presenilin-2
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot P49810 549
organism: Homo sapiens

Proprotein convertase subtilisin/kexin type 4
type: ProteinReference
xref: uniprot P29121 985
organism: Mus musculus

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot P29122 986
organism: Homo sapiens

uniprot Q9VC27 339
type: UnificationXref
id: Q9VC27
db: uniprot

Putative glycogen synthase kinase-3 homolog
type: ProteinReference
xref: uniprot P83101 1062
organism: Drosophila melanogaster

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot P29120 984
organism: Homo sapiens

uniprot Q9JIP6 426
type: UnificationXref
id: Q9JIP6
db: uniprot

Protein CBG23090
type: ProteinReference
xref: uniprot A8Y4R0 126
xref: PTHR11937:SF470
organism: Caenorhabditis briggsae

uniprot O88676 626
type: UnificationXref
id: O88676
db: uniprot

APH-1B'
type: ProteinReference
xref: uniprot Q0PY50 1038
xref: PTHR12889:SF1
organism: Rattus norvegicus

uniprot P79100 498
type: UnificationXref
id: P79100
db: uniprot

uniprot Q9ULZ9 728
type: UnificationXref
id: Q9ULZ9
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot A0A0G2K3B7 729
xref: PTHR12027:SF73
organism: Rattus norvegicus

ncbitaxon 367110 273
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot J9P4C6 529
type: UnificationXref
id: J9P4C6
db: uniprot

uniprot H2R821 542
type: UnificationXref
id: H2R821
db: uniprot

Matrix metalloproteinase-23
type: ProteinReference
xref: PTHR10201:SF7
xref: uniprot O75900 624
organism: Homo sapiens

uniprot P70701 856
type: UnificationXref
id: P70701
db: uniprot

uniprot M0R9D3 815
type: UnificationXref
id: M0R9D3
db: uniprot

uniprot Q54GX7 285
type: UnificationXref
id: Q54GX7
db: uniprot

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF201
xref: uniprot P62736 252
organism: Homo sapiens

Matrix metallopeptidase 24
type: ProteinReference
xref: uniprot F1MTK6 576
xref: PTHR10201:SF138
organism: Bos taurus

ncbitaxon 9615 14
type: UnificationXref
id: 9615
db: ncbitaxon

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot F6XJP7 963
organism: Mus musculus

uniprot P28466 839
type: UnificationXref
id: P28466
db: uniprot

Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like
type: ProteinReference
xref: PTHR13954:SF6
xref: uniprot Q9SF12 34
organism: Arabidopsis thaliana

E-cadherin intracellular fragment
type: ProteinReference
xref: P00168
comment: ENTITY_REFERENCE_NOTES=Long Name: E-cadherin intracellular fragment Synonym: Synonym not specified Accession: P00168
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.E-cadherin_br_intracellular_br_fragment
member entity reference: Cadherin-1
member entity reference: Cadherin-3
member entity reference: Cadherin 3
member entity reference: Uncharacterized protein
member entity reference: CDH1 isoform 1
member entity reference: Cadherin 1, type 1, E-cadherin (epithelial)
member entity reference: CDH3 isoform 2

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P62739 254
organism: Bos taurus

uniprot A0A1D5QBZ9 562
type: UnificationXref
id: A0A1D5QBZ9
db: uniprot

Actin, aortic smooth muscle
type: ProteinReference
xref: uniprot P62737 253
xref: PTHR11937:SF201
organism: Mus musculus

uniprot Q8BKG4 418
type: UnificationXref
id: Q8BKG4
db: uniprot

beta catenin s122 a153 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Endoplasmic reticulum to nucleus signaling 1
type: ProteinReference
xref: uniprot F1P7G9 13
xref: PTHR13954:SF17
organism: Canis lupus familiaris

uniprot Q9Z1J1 909
type: UnificationXref
id: Q9Z1J1
db: uniprot

Amyloid beta precursor protein binding family B member 2
type: ProteinReference
xref: uniprot A0A2I3TIR0 520
organism: Pan troglodytes

Matrix metallopeptidase 2
type: ProteinReference
xref: PTHR10201:SF29
xref: uniprot F1PMK7 582
organism: Canis lupus familiaris

uniprot H2Q4M7 609
type: UnificationXref
id: H2Q4M7
db: uniprot

uniprot E9Q1T6 49
type: UnificationXref
id: E9Q1T6
db: uniprot

uniprot E1BGJ0 48
type: UnificationXref
id: E1BGJ0
db: uniprot

TRANSPORT_LEFT__Complex__LRP_intracellular_fragment_Fe65_-RIGHT__Complex__LRP_intracellular_fragment_Fe65_-_r79
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1200
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 1201
left: Complex (LRP intracellular fragment/Fe65)
interaction type: TRANSPORT
right: Complex (LRP intracellular fragment/Fe65)

CD44 antigen
type: ProteinReference
xref: uniprot P16070 462
xref: PTHR10225:SF6
organism: Homo sapiens

Frizzled class receptor 5
type: ProteinReference
xref: uniprot F1MGM1 368
xref: PTHR11309:SF136
organism: Bos taurus

Protein Wnt
type: ProteinReference
xref: uniprot J9P5H0 814
xref: PTHR12027:SF33
organism: Canis lupus familiaris

Proprotein convertase subtilisin/kexin type 1
type: ProteinReference
xref: uniprot E2QX69 955
organism: Canis lupus familiaris

uniprot Q9WU82 949
type: UnificationXref
id: Q9WU82
db: uniprot

uniprot Q9QXQ5 879
type: UnificationXref
id: Q9QXQ5
db: uniprot

Short transient receptor potential channel 5
type: ProteinReference
xref: PTHR10117:SF76
xref: uniprot Q9UL62 513
organism: Homo sapiens

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 276

PTHR23277:SF69
type: RelationshipXref
id: PTHR23277:SF69
db: PANTHER Family
relationship type: By Homology

uniprot P10987 227
type: UnificationXref
id: P10987
db: uniprot

uniprot H2QAS4 17
type: UnificationXref
id: H2QAS4
db: uniprot

uniprot Q9GLE4 655
type: UnificationXref
id: Q9GLE4
db: uniprot

uniprot H2QC24 692
type: UnificationXref
id: H2QC24
db: uniprot

Low-density lipoprotein receptor-related protein 5
type: ProteinReference
xref: uniprot Q91VN0 81
xref: PTHR46513:SF16
organism: Mus musculus

uniprot A8XS95 124
type: UnificationXref
id: A8XS95
db: uniprot

uniprot F6XGB0 785
type: UnificationXref
id: F6XGB0
db: uniprot

uniprot F7DIB7 197
type: UnificationXref
id: F7DIB7
db: uniprot

uniprot P09237 630
type: UnificationXref
id: P09237
db: uniprot

CD44 molecule
type: ProteinReference
xref: uniprot A0A2I3TNC3 459
xref: PTHR10225:SF6
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10201:SF115
xref: uniprot F7GQW5 604
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GQW6 605
xref: PTHR10201:SF125
organism: Macaca mulatta

uniprot Q61086 410
type: UnificationXref
id: Q61086
db: uniprot

uniprot Q9QUQ5 506
type: UnificationXref
id: Q9QUQ5
db: uniprot

Transient receptor potential-gamma protein
type: ProteinReference
xref: uniprot Q9VJJ7 514
xref: PTHR10117:SF54
organism: Drosophila melanogaster

Histone acetyltransferase
type: ProteinReference
xref: uniprot F6UKT0 712
organism: Xenopus tropicalis

uniprot P78711 272
type: UnificationXref
id: P78711
db: uniprot

uniprot F7DQK7 198
type: UnificationXref
id: F7DQK7
db: uniprot

Lymphoid enhancer binding factor 1
type: ProteinReference
xref: uniprot A0A3Q1MZ99 891
xref: PTHR10373:SF11
organism: Bos taurus

Amyloid beta precursor protein binding family B member 1
type: ProteinReference
xref: uniprot E2QWV4 522
xref: PTHR14058:SF5
organism: Canis lupus familiaris

uniprot Q5ZMQ2 297
type: UnificationXref
id: Q5ZMQ2
db: uniprot

Proto-oncogene Wnt-1
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot P04426 824
organism: Mus musculus

uniprot F6U717 782
type: UnificationXref
id: F6U717
db: uniprot

uniprot F7ALP1 195
type: UnificationXref
id: F7ALP1
db: uniprot

Matrix metalloproteinase-19
type: ProteinReference
xref: PTHR10201:SF166
xref: uniprot Q9JHI0 657
organism: Mus musculus

uniprot H2Q7Z4 615
type: UnificationXref
id: H2Q7Z4
db: uniprot

Furin, paired basic amino acid cleaving enzyme
type: ProteinReference
xref: uniprot E2RSE6 957
xref: PTHR42884:SF1
organism: Canis lupus familiaris

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

uniprot Q9QXJ1 536
type: UnificationXref
id: Q9QXJ1
db: uniprot

uniprot Q99542 654
type: UnificationXref
id: Q99542
db: uniprot

uniprot F7EZ48 386
type: UnificationXref
id: F7EZ48
db: uniprot

uniprot H2QVA4 809
type: UnificationXref
id: H2QVA4
db: uniprot

GSK-3beta
type: Protein
entity reference: GSK-3beta
feature: ACTIVE 517
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Transient receptor potential cation channel, subfamily C, member 7b
type: ProteinReference
xref: PTHR10117:SF9
xref: uniprot A0A0G2KWQ6 465
organism: Danio rerio

Transcription factor cbf12
type: ProteinReference
xref: uniprot O74412 1015
organism: Schizosaccharomyces pombe

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF477
xref: uniprot F7A7I3 194
organism: Monodelphis domestica

TRANSPORT_LEFT__Nectin_1alpha_intracellular_fragment-RIGHT__Nectin_1alpha_intracellular_fragment-_r80
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 1180
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 1179
left: Nectin 1alpha intracellular fragment
interaction type: TRANSPORT
right: Nectin 1alpha intracellular fragment

Protein Wnt-11
type: ProteinReference
xref: uniprot P49339 848
xref: PTHR12027:SF7
organism: Gallus gallus

uniprot Q92048 870
type: UnificationXref
id: Q92048
db: uniprot

PARTICIPANT STOICHIOMETRY r64 1260
type: Stoichiometry
physical entity: E-cadherin
stoichiometric coefficient: 1.0

uniprot P48615 846
type: UnificationXref
id: P48615
db: uniprot

Protein Wnt-4
type: ProteinReference
xref: PTHR12027:SF101
xref: uniprot P49337 847
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r64 1263
type: Stoichiometry
physical entity: Afadin
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: uniprot C3YZ17 751
xref: PTHR12027:SF100
organism: Branchiostoma floridae

uniprot Q9HCX4 504
type: UnificationXref
id: Q9HCX4
db: uniprot

PARTICIPANT STOICHIOMETRY r64 1261
type: Stoichiometry
physical entity: alphacatenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 1262
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

uniprot A0A0G2K3B7 729
type: UnificationXref
id: A0A0G2K3B7
db: uniprot

uniprot O14640 694
type: UnificationXref
id: O14640
db: uniprot

uniprot A7MB36 667
type: UnificationXref
id: A7MB36
db: uniprot

TRUNCATION_LEFT__Nectin_1alpha_C_terminal_fragment-RIGHT__Nectin_1alpha_intracellular_fragment-_Nectin_1alpha_transmembrane_fragment-_r63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 1268
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 1267
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 1266
left: Nectin 1alpha C-terminal fragment
interaction type: TRUNCATION
right: Nectin 1alpha intracellular fragment
right: Nectin 1alpha transmembrane fragment

LDL receptor related protein 2
type: ProteinReference
xref: uniprot H2QIY0 69
xref: PTHR22722:SF5
organism: Pan troglodytes

uniprot H2R050 393
type: UnificationXref
id: H2R050
db: uniprot

E-cadherin
type: ProteinReference
xref: P00118
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.E-cadherin
comment: ENTITY_REFERENCE_NOTES=Long Name: E-cadherin Synonym: Synonym not specified Accession: P00118
member entity reference: Cadherin 3
member entity reference: Cadherin-1
member entity reference: CDH3 isoform 2
member entity reference: Cadherin-3
member entity reference: DE-cadherin
member entity reference: AGAP007207-PA
member entity reference: CDH1 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Cadherin 1, type 1, E-cadherin (epithelial)

Predicted protein
type: ProteinReference
xref: uniprot A9TVP1 129
xref: PTHR11937:SF387
organism: Physcomitrella patens

uniprot O95704 531
type: UnificationXref
id: O95704
db: uniprot

Presenilin-like protein At2g29900
type: ProteinReference
xref: PTHR10202:SF13
xref: uniprot Q9SIK7 558
organism: Arabidopsis thaliana

MMP15 isoform 1
type: ProteinReference
xref: PTHR10201:SF25
xref: uniprot H2QB81 616
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r5 1189
type: Stoichiometry
physical entity: Complex (Notch N-terminal fragment/Notch C-terminal fragment)
stoichiometric coefficient: 1.0

uniprot A0A1D5RE70 735
type: UnificationXref
id: A0A1D5RE70
db: uniprot

Cadherin-3
type: ProteinReference
xref: PTHR24027:SF267
xref: uniprot P22223 349
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RKF7 376
xref: PTHR11309:SF34
organism: Monodelphis domestica

Short transient receptor potential channel 3
type: ProteinReference
xref: PTHR10117:SF8
xref: uniprot Q9QZC1 509
organism: Mus musculus

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Ire 1 s136 a168 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

PARTICIPANT STOICHIOMETRY r5 1191
type: Stoichiometry
physical entity: Complex (Notch N-terminal fragment/Notch extracellular fragment)
stoichiometric coefficient: 1.0

Junction plakoglobin
type: ProteinReference
xref: PTHR45976:SF3
xref: uniprot Q8SPJ1 936
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r5 1190
type: Stoichiometry
physical entity: Notch transmembrane fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r80 1179
type: Stoichiometry
physical entity: Nectin 1alpha intracellular fragment
stoichiometric coefficient: 1.0

uniprot B3S5E4 140
type: UnificationXref
id: B3S5E4
db: uniprot

Notch transmembrane fragment
type: ProteinReference
xref: P00135
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Notch_br_transmembrane_br_fragment
comment: ENTITY_REFERENCE_NOTES=Long Name: Notch transmembrane fragment Synonym: Synonym not specified Accession: P00135
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Notch 4
member entity reference: Notch 3
member entity reference: Neurogenic locus Notch protein
member entity reference: Notch 1
member entity reference: NOTCH3 isoform 1
member entity reference: NOTCH1 isoform 1

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Z2A8 595
xref: PTHR10201:SF237
organism: Macaca mulatta

Dishevelled segment polarity protein 3
type: ProteinReference
xref: uniprot D4ADV8 684
xref: PTHR10878:SF6
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: uniprot F6PJR9 776
xref: PTHR12027:SF70
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Erb_B4_C_terminal_fragment-RIGHT__Erb_B4_transmembrane_fragment-_Erb_B4_intracellular_fragment-_r16
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

uniprot C3XYC8 150
type: UnificationXref
id: C3XYC8
db: uniprot

PARTICIPANT STOICHIOMETRY r80 1180
type: Stoichiometry
physical entity: Nectin 1alpha intracellular fragment
stoichiometric coefficient: 1.0

LDL receptor related protein 3
type: ProteinReference
xref: uniprot H2QG00 67
xref: PTHR24270:SF22
organism: Pan troglodytes

Serine/threonine-protein kinase/endoribonuclease IRE1
type: ProteinReference
xref: uniprot O75460 20
xref: PTHR13954:SF17
organism: Homo sapiens

uniprot A8WS32 120
type: UnificationXref
id: A8WS32
db: uniprot

Frizzled class receptor 8
type: ProteinReference
xref: PTHR11309:SF90
xref: uniprot F6VM33 381
organism: Xenopus tropicalis

Fe65 s25 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

uniprot F7HKD3 799
type: UnificationXref
id: F7HKD3
db: uniprot

uniprot A9TBG2 127
type: UnificationXref
id: A9TBG2
db: uniprot

uniprot P83101 1062
type: UnificationXref
id: P83101
db: uniprot

PTHR21092:SF0
type: RelationshipXref
id: PTHR21092:SF0
db: PANTHER Family
relationship type: By Homology

Actin
type: ProteinReference
xref: uniprot A2G1K5 104
organism: Trichomonas vaginalis

uniprot P49810 549
type: UnificationXref
id: P49810
db: uniprot

uniprot Q8LNI5 1066
type: UnificationXref
id: Q8LNI5
db: uniprot

PCSK1 isoform 2
type: ProteinReference
xref: uniprot H2QR92 972
organism: Pan troglodytes

Amyloid-beta precursor protein
type: ProteinReference
xref: uniprot P05067 39
xref: PTHR23103:SF7
organism: Homo sapiens

ncbitaxon 284811 310
type: UnificationXref
id: 284811
db: ncbitaxon

DISSOCIATION
type: InteractionVocabulary

PTHR10117:SF25
type: RelationshipXref
id: PTHR10117:SF25
db: PANTHER Family
relationship type: By Homology

Short transient receptor potential channel 5
type: ProteinReference
xref: PTHR10117:SF76
xref: uniprot F7CXM3 482
organism: Macaca mulatta

Actin-2
type: ProteinReference
xref: uniprot Q8ILW9 320
organism: Plasmodium falciparum

Lymphoid enhancer-binding factor 1
type: ProteinReference
xref: PTHR10373:SF11
xref: uniprot F6WCX0 896
organism: Xenopus tropicalis

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot A0A2I3SXI2 1048
organism: Pan troglodytes

Histone acetyltransferase KAT7
type: ProteinReference
xref: uniprot Q810T5 720
organism: Rattus norvegicus

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot Q63415 995
organism: Rattus norvegicus

Matrix metallopeptidase 24
type: ProteinReference
xref: uniprot F6SPF3 586
xref: PTHR10201:SF138
organism: Monodelphis domestica

ncbitaxon 3218 128
type: UnificationXref
id: 3218
db: ncbitaxon

Ire-1 C-terminal fragment
type: Protein
entity reference: Ire-1 C-terminal fragment
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Recombination signal-binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: uniprot F7BXC9 1011
xref: PTHR10665:SF3
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r20 1295
type: Stoichiometry
physical entity: CD44 C-terminal fragment
stoichiometric coefficient: 1.0

TRUNCATION_LEFT__CD44-RIGHT__CD44_C_terminal_fragment-_CD44_N_terminal_fragment-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1183
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1181
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1182
left: CD44
interaction type: TRUNCATION
right: CD44 C-terminal fragment
right: CD44 N-terminal fragment

C99 s26 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: C99
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 21

PARTICIPANT STOICHIOMETRY r20 1297
type: Stoichiometry
physical entity: CD44 intracellular fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 1296
type: Stoichiometry
physical entity: CD44 transmembrane fragment
stoichiometric coefficient: 1.0

Complex (beta-catenin/TCF/ LEF)
type: Complex
component stoichiometry: TCF LEF s74 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: beta catenin s70 sa41 STOICHIOMETRY ID COMPLEX
component: TCF/LEF
component: beta-catenin
feature: COMPLEX BINDING FEATURE s253 a242 1093
feature: COMPLEX BINDING FEATURE s253 a242 1091
feature: ACTIVE 517
cellular location: nucleus

uniprot F6R9F4 183
type: UnificationXref
id: F6R9F4
db: uniprot

uniprot H2Q4M9 611
type: UnificationXref
id: H2Q4M9
db: uniprot

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3SHB6 568
type: UnificationXref
id: A0A2I3SHB6
db: uniprot

Erb-B4 transmembrane fragment
type: Protein
entity reference: Erb-B4 transmembrane fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EC93 486
xref: PTHR10117:SF9
organism: Ornithorhynchus anatinus

PTHR42884:SF1
type: RelationshipXref
id: PTHR42884:SF1
db: PANTHER Family
relationship type: By Homology

Actin-1
type: ProteinReference
xref: uniprot P0DM41 222
xref: PTHR11937:SF387
organism: Caenorhabditis elegans

uniprot Q9EQD0 423
type: UnificationXref
id: Q9EQD0
db: uniprot

Gamma-secretase subunit aph-1
type: ProteinReference
xref: uniprot O45876 1037
xref: PTHR12889:SF0
organism: Caenorhabditis elegans

Actin
type: ProteinReference
xref: uniprot A2FA04 102
organism: Trichomonas vaginalis

uniprot C3XYD4 152
type: UnificationXref
id: C3XYD4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10201:SF166
xref: uniprot F7GZ45 606
organism: Macaca mulatta

uniprot D3ZCR1 754
type: UnificationXref
id: D3ZCR1
db: uniprot

NOTCH3 isoform 1
type: ProteinReference
xref: uniprot H2QFL8 444
xref: PTHR24033:SF176
organism: Pan troglodytes

uniprot H2Q4M8 610
type: UnificationXref
id: H2Q4M8
db: uniprot

Transient receptor potential cation channel subfamily C member 7
type: ProteinReference
xref: PTHR10117:SF9
xref: uniprot F1PVZ8 474
organism: Canis lupus familiaris

uniprot Q7XIT1 27
type: UnificationXref
id: Q7XIT1
db: uniprot

uniprot H2QG41 920
type: UnificationXref
id: H2QG41
db: uniprot

uniprot F7DIA9 384
type: UnificationXref
id: F7DIA9
db: uniprot

uniprot H9G0E6 1036
type: UnificationXref
id: H9G0E6
db: uniprot

uniprot P26016 981
type: UnificationXref
id: P26016
db: uniprot

Nectin-1
type: ProteinReference
xref: PTHR23277:SF69
xref: uniprot Q15223 706
organism: Homo sapiens

uniprot O14641 695
type: UnificationXref
id: O14641
db: uniprot

PTHR10117:SF47
type: RelationshipXref
id: PTHR10117:SF47
db: PANTHER Family
relationship type: By Homology

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Capacitative_calcium_channels-RIGHT__Capacitative_calcium_channels-_re56
controller: Presenilin

Notch N terminal fragment s37 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Notch N-terminal fragment
stoichiometric coefficient: 1.0

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot F1MAD0 50
xref: PTHR46513:SF16
organism: Rattus norvegicus

uniprot F1MGM1 368
type: UnificationXref
id: F1MGM1
db: uniprot

Ire-1 C-terminal fragment
type: ProteinReference
xref: P00125
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Ire-1_br_C-terminal_br_fragment
comment: ENTITY_REFERENCE_NOTES=Long Name: Ire-1 C-terminal fragment Synonym: Synonym not specified Accession: P00125
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE1
member entity reference: Endoplasmic reticulum to nucleus-signaling 1
member entity reference: Endoplasmic reticulum to nucleus signaling 2
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE1a
member entity reference: Endoplasmic reticulum to nucleus signaling 1
member entity reference: Endoplasmic reticulum (ER) to nucleus signalling 2 (Predicted)
member entity reference: Serine/threonine-protein kinase ppk4
member entity reference: ERN1 isoform 4
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE1b
member entity reference: Serine/threonine-protein kinase/endoribonuclease IRE2
member entity reference: Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like

uniprot P14780 631
type: UnificationXref
id: P14780
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot F7E738 792
organism: Macaca mulatta

uniprot A0A3Q2TVV5 1049
type: UnificationXref
id: A0A3Q2TVV5
db: uniprot

uniprot P68136 269
type: UnificationXref
id: P68136
db: uniprot

Gamma-secretase subunit Aph-1
type: ProteinReference
xref: uniprot Q9VQG2 1047
xref: PTHR12889:SF0
organism: Drosophila melanogaster

PTHR10117:SF54
type: RelationshipXref
id: PTHR10117:SF54
db: PANTHER Family
relationship type: By Homology

PTHR10117:SF56
type: RelationshipXref
id: PTHR10117:SF56
db: PANTHER Family
relationship type: By Homology

uniprot Q9ULV1 431
type: UnificationXref
id: Q9ULV1
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F1N5R1 774
xref: PTHR12027:SF82
organism: Bos taurus

PTHR10117:SF51
type: RelationshipXref
id: PTHR10117:SF51
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MSZ4 681
xref: PTHR10878:SF8
organism: Bos taurus

uniprot Q9JHI0 657
type: UnificationXref
id: Q9JHI0
db: uniprot

uniprot Q5E9B5 291
type: UnificationXref
id: Q5E9B5
db: uniprot

uniprot P48995 497
type: UnificationXref
id: P48995
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF453
xref: uniprot W4Y969 329
organism: Strongylocentrotus purpuratus

E-cadherin
type: Protein
entity reference: E-cadherin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Amyloid-beta A4 precursor protein-binding family B member 2
type: ProteinReference
xref: uniprot Q92870 534
organism: Homo sapiens

ncbitaxon 184922 117
type: UnificationXref
id: 184922
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__C99_Fe65_-RIGHT__Complex__AICD_Fe65_-_Abeta-_r50
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

uniprot E2R7K2 686
type: UnificationXref
id: E2R7K2
db: uniprot

uniprot F1Q270 585
type: UnificationXref
id: F1Q270
db: uniprot

Notch transmembrane fragment
type: Protein
entity reference: Notch transmembrane fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Actin-12
type: ProteinReference
xref: uniprot P53497 242
organism: Arabidopsis thaliana

Low-density lipoprotein receptor-related protein 1B
type: ProteinReference
xref: uniprot Q9JI18 83
xref: PTHR22722:SF6
organism: Mus musculus

AGAP009816-PA
type: ProteinReference
xref: uniprot Q7PM79 1040
xref: PTHR12889:SF0
organism: Anopheles gambiae

Actin-4
type: ProteinReference
xref: uniprot P53494 241
organism: Arabidopsis thaliana

Neurogenic locus notch homolog protein 1
type: ProteinReference
xref: PTHR22804:SF52
xref: uniprot Q07008 452
organism: Rattus norvegicus

Matrilysin
type: ProteinReference
xref: uniprot P09237 630
xref: PTHR10201:SF143
organism: Homo sapiens

uniprot F1NEW3 670
type: UnificationXref
id: F1NEW3
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot Q7PM77 868
xref: PTHR12027:SF98
organism: Anopheles gambiae

uniprot E1BKL2 765
type: UnificationXref
id: E1BKL2
db: uniprot

Actin-7
type: ProteinReference
xref: uniprot P53492 240
organism: Arabidopsis thaliana

uniprot Q9UVF3 326
type: UnificationXref
id: Q9UVF3
db: uniprot

Frizzled class receptor 2
type: ProteinReference
xref: uniprot F1QBI2 372
xref: PTHR11309:SF34
organism: Danio rerio

ACTin
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot O45815 212
organism: Caenorhabditis elegans

Actin-related protein 2
type: ProteinReference
xref: uniprot P53489 239
xref: PTHR11937:SF37
organism: Caenorhabditis elegans

uniprot P02572 214
type: UnificationXref
id: P02572
db: uniprot

APPbeta
type: Protein
entity reference: APPbeta
comment: SPECIES_TYPE=PROTEIN

uniprot F0ZK40 173
type: UnificationXref
id: F0ZK40
db: uniprot

uniprot Q61143 500
type: UnificationXref
id: Q61143
db: uniprot

uniprot Q75D00 309
type: UnificationXref
id: Q75D00
db: uniprot

uniprot Q8QFM3 421
type: UnificationXref
id: Q8QFM3
db: uniprot

uniprot O14904 818
type: UnificationXref
id: O14904
db: uniprot

Transient receptor potential cation channel subfamily C member 3
type: ProteinReference
xref: PTHR10117:SF8
xref: uniprot J9P9P7 492
organism: Canis lupus familiaris

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa39 1108
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot E2RMU9 573
type: UnificationXref
id: E2RMU9
db: uniprot

PARTICIPANT STOICHIOMETRY r28 1280
type: Stoichiometry
physical entity: Complex (E-cadherin/beta-catenin/ gammacatenin/alphacatenin/ actin)
stoichiometric coefficient: 1.0

Novel actin protein
type: ProteinReference
xref: uniprot Q6IQL9 302
xref: PTHR11937:SF176
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r28 1281
type: Stoichiometry
physical entity: E-cadherin C-terminal fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r28 1282
type: Stoichiometry
physical entity: E-cadherin N-terminal fragment
stoichiometric coefficient: 1.0

CD44 transmembrane fragment
type: ProteinReference
xref: P00167
comment: ENTITY_REFERENCE_NOTES=Long Name: CD44 transmembrane fragment Synonym: Synonym not specified Accession: P00167
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.CD44_br_transmembrane_br_fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: CD44 antigen
member entity reference: CD44 molecule
member entity reference: Phagocytic glycoprotein I

PTHR10117:SF76
type: RelationshipXref
id: PTHR10117:SF76
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot P53488 238
organism: Gallus gallus

Os01g0296100 protein
type: ProteinReference
xref: uniprot Q94IZ2 1068
organism: Oryza sativa

FZD5 isoform 1
type: ProteinReference
xref: uniprot H2QJA9 392
xref: PTHR11309:SF136
organism: Pan troglodytes

alphacatenin
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa14 1102
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CSL s5 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CSL
stoichiometric coefficient: 1.0

uniprot J9NZJ2 812
type: UnificationXref
id: J9NZJ2
db: uniprot

uniprot Q07954 79
type: UnificationXref
id: Q07954
db: uniprot

PARTICIPANT STOICHIOMETRY r25 1286
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

Tripartite motif-containing protein 3
type: ProteinReference
xref: uniprot O75382 674
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r25 1287
type: Stoichiometry
physical entity: LRP intracellular fragment
stoichiometric coefficient: 1.0

Interstitial collagenase
type: ProteinReference
xref: PTHR10201:SF151
xref: uniprot P28053 633
organism: Bos taurus

uniprot Q96292 322
type: UnificationXref
id: Q96292
db: uniprot

uniprot P60710 247
type: UnificationXref
id: P60710
db: uniprot

Actin, cytoplasmic type 5
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot P53478 237
organism: Gallus gallus

TRIM2 isoform 7
type: ProteinReference
xref: uniprot A0A2I3TV72 665
organism: Pan troglodytes

Gamma-secretase subunit APH-1A
type: ProteinReference
xref: PTHR12889:SF3
xref: uniprot Q8BVF7 1041
organism: Mus musculus

uniprot P45452 639
type: UnificationXref
id: P45452
db: uniprot

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 1014

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot F6X3B2 784
organism: Xenopus tropicalis

CD44 C-terminal fragment
type: ProteinReference
xref: P00123
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.CD44_br_C-terminal_br_fragment
comment: ENTITY_REFERENCE_NOTES=Long Name: CD44 C-terminal fragment Synonym: Synonym not specified Accession: P00123
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: CD44 antigen
member entity reference: CD44 molecule
member entity reference: Phagocytic glycoprotein I

uniprot F7AWF2 713
type: UnificationXref
id: F7AWF2
db: uniprot

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 38

PARTICIPANT STOICHIOMETRY r25 1288
type: Stoichiometry
physical entity: Complex (LRP intracellular fragment/Fe65)
stoichiometric coefficient: 1.0

Frizzled
type: ProteinReference
xref: uniprot P18537 403
xref: PTHR11309:SF47
organism: Drosophila melanogaster

E-cadherin intracellular fragment
type: Protein
entity reference: E-cadherin intracellular fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__NICD-RIGHT__NICD-_r75
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 1230
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 1229
left: NICD
interaction type: TRANSPORT
right: NICD

Aph-1
type: Protein
entity reference: Aph-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa26 1114
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Actin, cytoskeletal 3A
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P53474 236
organism: Strongylocentrotus purpuratus

LDL receptor related protein 1
type: ProteinReference
xref: PTHR24270:SF23
xref: uniprot J9P315 70
organism: Canis lupus familiaris

uniprot O23145 1055
type: UnificationXref
id: O23145
db: uniprot

Protein Wnt-7b
type: ProteinReference
xref: uniprot P28047 837
xref: PTHR12027:SF73
organism: Mus musculus

Notch
type: ProteinReference
xref: P00176
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Notch Synonym: Synonym not specified Accession: P00176
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Notch
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Notch 4
member entity reference: Notch 3
member entity reference: Neurogenic locus Notch protein
member entity reference: Notch 1
member entity reference: NOTCH3 isoform 1
member entity reference: NOTCH1 isoform 1

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B3RKR4 137
organism: Trichoplax adhaerens

Proprotein convertase subtilisin/kexin type 7
type: ProteinReference
xref: uniprot A0A2I3SSR3 952
organism: Pan troglodytes

TRUNCATION_LEFT__CD44_C_terminal_fragment-RIGHT__CD44_transmembrane_fragment-_CD44_intracellular_fragment-_r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1297
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1296
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 1295
left: CD44 C-terminal fragment
interaction type: TRUNCATION
right: CD44 transmembrane fragment
right: CD44 intracellular fragment

Protein Wnt
type: ProteinReference
xref: uniprot A0A1D5RE70 735
xref: PTHR12027:SF76
organism: Macaca mulatta

uniprot F7EV26 793
type: UnificationXref
id: F7EV26
db: uniprot

uniprot A0A3Q1MIR9 709
type: UnificationXref
id: A0A3Q1MIR9
db: uniprot

uniprot Q9R0S2 659
type: UnificationXref
id: Q9R0S2
db: uniprot

uniprot H2Q8K1 541
type: UnificationXref
id: H2Q8K1
db: uniprot

72 kDa type IV collagenase
type: ProteinReference
xref: PTHR10201:SF29
xref: uniprot Q90611 653
organism: Gallus gallus

uniprot F6V5F4 380
type: UnificationXref
id: F6V5F4
db: uniprot

Histone acetyltransferase
type: ProteinReference
xref: uniprot E2RRZ5 711
organism: Canis lupus familiaris

uniprot H2QNU7 693
type: UnificationXref
id: H2QNU7
db: uniprot

uniprot Q28GF7 922
type: UnificationXref
id: Q28GF7
db: uniprot

TRANSPORT_LEFT__beta_catenin-RIGHT__beta_catenin-_r81
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1177
participant stoichiometry: PARTICIPANT STOICHIOMETRY r81 1178
left: beta-catenin
interaction type: TRANSPORT
right: beta-catenin

uniprot B0LK22 746
type: UnificationXref
id: B0LK22
db: uniprot

uniprot E2R6Q9 470
type: UnificationXref
id: E2R6Q9
db: uniprot

Short transient receptor potential channel 3
type: ProteinReference
xref: PTHR10117:SF8
xref: uniprot Q9JMI9 505
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot J9P2Q5 813
organism: Canis lupus familiaris

Presenilin
type: Protein
entity reference: Presenilin
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YKS6 155
xref: PTHR11937:SF359
organism: Branchiostoma floridae

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot D3ZND6 757
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot C3Z299 954
organism: Branchiostoma floridae

Histone acetyltransferase
type: ProteinReference
xref: uniprot F7AWF2 713
xref: PTHR10615:SF183
organism: Monodelphis domestica

uniprot P33436 636
type: UnificationXref
id: P33436
db: uniprot

uniprot P51029 850
type: UnificationXref
id: P51029
db: uniprot

PARTICIPANT STOICHIOMETRY r45 1220
type: Stoichiometry
physical entity: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
stoichiometric coefficient: 1.0

Shaggy-related protein kinase beta
type: ProteinReference
xref: uniprot O23145 1055
organism: Arabidopsis thaliana

uniprot F6XMD3 786
type: UnificationXref
id: F6XMD3
db: uniprot

uniprot F1N6L8 775
type: UnificationXref
id: F1N6L8
db: uniprot

uniprot F6W5A7 589
type: UnificationXref
id: F6W5A7
db: uniprot

ncbitaxon 45351 111
type: UnificationXref
id: 45351
db: ncbitaxon

Histone acetyltransferase KAT5
type: ProteinReference
xref: uniprot Q99MK2 723
xref: PTHR10615:SF183
organism: Rattus norvegicus

Actin, beta-like 2
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot D3ZRN3 162
organism: Rattus norvegicus

Short transient receptor potential channel 2
type: ProteinReference
xref: PTHR10117:SF6
xref: uniprot Q9R244 510
organism: Mus musculus

Protein Wnt
type: ProteinReference
xref: uniprot F6U717 782
xref: PTHR12027:SF92
organism: Macaca mulatta

PTHR12027:SF111
type: RelationshipXref
id: PTHR12027:SF111
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF112
type: RelationshipXref
id: PTHR12027:SF112
db: PANTHER Family
relationship type: By Homology

Actin, putative (Fragment)
type: ProteinReference
xref: uniprot B7PBG2 141
xref: PTHR11937:SF387
organism: Ixodes scapularis

uniprot F6X3B2 784
type: UnificationXref
id: F6X3B2
db: uniprot

uniprot A0A1D5R803 734
type: UnificationXref
id: A0A1D5R803
db: uniprot

MMP19 isoform 4
type: ProteinReference
xref: uniprot H2Q667 614
xref: PTHR10201:SF166
organism: Pan troglodytes

uniprot E2R9M9 365
type: UnificationXref
id: E2R9M9
db: uniprot

uniprot D3ZTI7 10
type: UnificationXref
id: D3ZTI7
db: uniprot

uniprot A0A2I3TGC6 355
type: UnificationXref
id: A0A2I3TGC6
db: uniprot

Erb-B4 transmembrane fragment
type: ProteinReference
xref: P00113
comment: ENTITY_REFERENCE_NOTES=Long Name: Erb-B4 transmembrane fragment Synonym: Synonym not specified Accession: P00113
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Erb-B4_br_transmembrane_br_fragment
member entity reference: Receptor protein-tyrosine kinase
member entity reference: Receptor tyrosine-protein kinase erbB-4

uniprot E7FC99 938
type: UnificationXref
id: E7FC99
db: uniprot

uniprot E2QY91 685
type: UnificationXref
id: E2QY91
db: uniprot

uniprot O00744 816
type: UnificationXref
id: O00744
db: uniprot

PARTICIPANT STOICHIOMETRY r45 1215
type: Stoichiometry
physical entity: Nicastrin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 1216
type: Stoichiometry
physical entity: Presenilin N-terminal fragment
stoichiometric coefficient: 1.0

ncbitaxon 7227 215
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot A7S0V7 112
type: UnificationXref
id: A7S0V7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YB95 1010
xref: PTHR10665:SF3
organism: Monodelphis domestica

E-cadherin
type: Protein
entity reference: E-cadherin
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa24 1144
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24044:SF450
type: RelationshipXref
id: PTHR24044:SF450
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YC50 154
xref: PTHR11937:SF446
organism: Branchiostoma floridae

Frizzled s78 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Frizzled
stoichiometric coefficient: 1.0

Notch N-terminal fragment
type: Protein
entity reference: Notch N-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa1 1158
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR12027:SF100
type: RelationshipXref
id: PTHR12027:SF100
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot H2Q2F4 804
organism: Pan troglodytes

PTHR12027:SF101
type: RelationshipXref
id: PTHR12027:SF101
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F3M6 527
organism: Macaca mulatta

PTHR12027:SF102
type: RelationshipXref
id: PTHR12027:SF102
db: PANTHER Family
relationship type: By Homology

uniprot F7B627 59
type: UnificationXref
id: F7B627
db: uniprot

Unfolded protein
type: Protein
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Lymphoid enhancer binding factor 1
type: ProteinReference
xref: uniprot A0A2I3SSM9 889
xref: PTHR10373:SF11
organism: Pan troglodytes

Presenilin-2
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot Q9XT96 560
organism: Bos taurus

PTHR12027:SF105
type: RelationshipXref
id: PTHR12027:SF105
db: PANTHER Family
relationship type: By Homology

Presenilin-1
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot Q9XT97 561
organism: Bos taurus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot M0R9D3 815
organism: Rattus norvegicus

uniprot Q9C040 677
type: UnificationXref
id: Q9C040
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ire_1-RIGHT__Ire_1-_r37
controller: Unfolded protein

PARTICIPANT STOICHIOMETRY r45 1218
type: Stoichiometry
physical entity: Presenilin C-terminal fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r45 1217
type: Stoichiometry
physical entity: Aph-1
stoichiometric coefficient: 1.0

LRP
type: ProteinReference
xref: P00150
standard name: Low-density lipoprotein receptor-related protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Low-density lipoprotein receptor-related protein Synonym: Synonym not specified Accession: P00150
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.LRP
member entity reference: Low-density lipoprotein receptor-related protein 1B
member entity reference: LDL receptor related protein 1
member entity reference: Low-density lipoprotein receptor-related protein 6
member entity reference: Low-density lipoprotein receptor-related protein
member entity reference: LDL receptor-related protein 1
member entity reference: LDL receptor related protein 3
member entity reference: LDL receptor related protein 6
member entity reference: LDL receptor related protein 4
member entity reference: Low-density lipoprotein receptor-related protein 2
member entity reference: Uncharacterized protein
member entity reference: Low-density lipoprotein receptor-related protein 3
member entity reference: LDL receptor related protein 1B
member entity reference: Low-density lipoprotein receptor-related protein 5
member entity reference: Low-density lipoprotein receptor-related protein 4
member entity reference: Low density lipoprotein receptor-related protein 3
member entity reference: Prolow-density lipoprotein receptor-related protein 1
member entity reference: LDL receptor related protein 2

PARTICIPANT STOICHIOMETRY r45 1219
type: Stoichiometry
physical entity: Pen-2
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF70
xref: uniprot H2QVA4 809
organism: Pan troglodytes

Neuroendocrine convertase 2
type: ProteinReference
xref: uniprot P21661 978
organism: Mus musculus

uniprot P34960 637
type: UnificationXref
id: P34960
db: uniprot

Tip60 s36 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tip60
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 1301
type: Stoichiometry
physical entity: Complex (APP/Fe65)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 1302
type: Stoichiometry
physical entity: Complex (C99/Fe65)
stoichiometric coefficient: 1.0

uniprot F7CZL9 483
type: UnificationXref
id: F7CZL9
db: uniprot

uniprot Q9XT97 561
type: UnificationXref
id: Q9XT97
db: uniprot

PARTICIPANT STOICHIOMETRY r51 1303
type: Stoichiometry
physical entity: APPbeta
stoichiometric coefficient: 1.0

Leishmania major
type: BioSource
xref: ncbitaxon 5664 325

uniprot F1PIB1 688
type: UnificationXref
id: F1PIB1
db: uniprot

Dishevelled segment polarity protein 3
type: ProteinReference
xref: uniprot F1PIB1 688
xref: PTHR10878:SF6
organism: Canis lupus familiaris

uniprot Q9NQB0 904
type: UnificationXref
id: Q9NQB0
db: uniprot

uniprot F7HRY3 691
type: UnificationXref
id: F7HRY3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TUR3 187
xref: PTHR11937:SF192
organism: Monodelphis domestica

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 5

LDL receptor related protein 1
type: ProteinReference
xref: PTHR24270:SF23
xref: uniprot A0A2I3S3K1 45
organism: Pan troglodytes

CDH3 isoform 2
type: ProteinReference
xref: PTHR24027:SF267
xref: uniprot H2QBE4 345
organism: Pan troglodytes

Nectin 1alpha s11 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Nectin 1alpha
stoichiometric coefficient: 1.0

uniprot Q9URT9 1074
type: UnificationXref
id: Q9URT9
db: uniprot

uniprot P10287 347
type: UnificationXref
id: P10287
db: uniprot

uniprot O54732 621
type: UnificationXref
id: O54732
db: uniprot

Low-density lipoprotein receptor-related protein 1B
type: ProteinReference
xref: uniprot Q9NZR2 84
xref: PTHR22722:SF6
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: uniprot H2QJF8 808
xref: PTHR12027:SF89
organism: Pan troglodytes

uniprot A0A2I3S3K1 45
type: UnificationXref
id: A0A2I3S3K1
db: uniprot

uniprot F7D1A1 789
type: UnificationXref
id: F7D1A1
db: uniprot

uniprot A0A2I3SF35 567
type: UnificationXref
id: A0A2I3SF35
db: uniprot

Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a
type: ProteinReference
xref: PTHR12889:SF3
xref: uniprot A0A0G2K6H8 1031
organism: Rattus norvegicus

uniprot Q92050 871
type: UnificationXref
id: Q92050
db: uniprot

PTHR24044:SF470
type: RelationshipXref
id: PTHR24044:SF470
db: PANTHER Family
relationship type: By Homology

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot F1N1K8 52
xref: PTHR46513:SF16
organism: Bos taurus

Catenin beta-1
type: ProteinReference
xref: uniprot Q0VCX4 947
xref: PTHR45976:SF4
organism: Bos taurus

TACE
type: ProteinReference
xref: P00147
standard name: TNF-alpha converting enzyme
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.TACE
comment: ENTITY_REFERENCE_NOTES=Long Name: TNF-alpha converting enzyme Synonym: ADAM17,alpha-secretase Accession: P00147
member entity reference: Disintegrin and metalloproteinase domain-containing protein 17
member entity reference: ADAM metallopeptidase domain 17

Nectin 1alpha
type: Protein
entity reference: Nectin 1alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa18 1132
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot H2KNE6 203
organism: Phaeosphaeria nodorum

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__Nectin_1alpha_Afadin__alphacatenin_actin__beta_catenin_gammacatenin__E_cadherin_-RIGHT__Nectin_1alpha_C_terminal_fragment-_Nectin_1alpha_N_terminal_fragment-_r61
controller: TACE

Notch C terminal fragment s40 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Notch C-terminal fragment
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase/endoribonuclease IRE2
type: ProteinReference
xref: PTHR13954:SF15
xref: uniprot Q9Z2E3 35
organism: Mus musculus

Muscle-specific actin
type: ProteinReference
xref: PTHR11937:SF162
xref: uniprot E9FRT1 166
organism: Daphnia pulex

uniprot C3ZCG7 753
type: UnificationXref
id: C3ZCG7
db: uniprot

Lymphocyte enhancer binding factor 1
type: ProteinReference
xref: PTHR10373:SF11
xref: uniprot Q9W7C0 907
organism: Danio rerio

uniprot Q9NPG1 427
type: UnificationXref
id: Q9NPG1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DQK7 198
xref: PTHR11937:SF201
organism: Monodelphis domestica

Actin 7
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TBG2 127
organism: Physcomitrella patens

uniprot Q9R172 457
type: UnificationXref
id: Q9R172
db: uniprot

Short transient receptor potential channel 2
type: ProteinReference
xref: uniprot Q9R283 511
xref: PTHR10117:SF6
organism: Rattus norvegicus

Nectin 1alpha s50 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Nectin 1alpha
stoichiometric coefficient: 1.0

uniprot G3MX13 63
type: UnificationXref
id: G3MX13
db: uniprot

Actin
type: ProteinReference
xref: uniprot Q5KP06 292
xref: PTHR11937:SF387
organism: Cryptococcus neoformans

uniprot P56818 1028
type: UnificationXref
id: P56818
db: uniprot

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: uniprot Q5E9B5 291
xref: PTHR11937:SF201
organism: Bos taurus

uniprot D4A9D7 761
type: UnificationXref
id: D4A9D7
db: uniprot

Ser beta catenin s121 a152 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Ser
feature location: Ser beta catenin s121 a152 rs1 Ser
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=Ser

uniprot Q562R1 288
type: UnificationXref
id: Q562R1
db: uniprot

uniprot C3ZHN4 159
type: UnificationXref
id: C3ZHN4
db: uniprot

Actin, alpha skeletal muscle
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot P68134 268
organism: Mus musculus

Lymphoid enhancer binding factor 1
type: ProteinReference
xref: PTHR10373:SF11
xref: uniprot F1Q334 894
organism: Canis lupus familiaris

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68133 267
xref: PTHR11937:SF193
organism: Homo sapiens

Protein Wnt-6
type: ProteinReference
xref: PTHR12027:SF72
xref: uniprot P22727 833
organism: Mus musculus

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68136 269
xref: PTHR11937:SF193
organism: Rattus norvegicus

uniprot E2QVW6 669
type: UnificationXref
id: E2QVW6
db: uniprot

Os01g0252100 protein
type: ProteinReference
xref: uniprot Q9LIS6 1071
organism: Oryza sativa

Protein Wnt-5b
type: ProteinReference
xref: uniprot P22726 832
xref: PTHR12027:SF87
organism: Mus musculus

HETERODIMER ASSOCIATION LEFT Nicastrin- Presenilin N terminal fragment- Aph 1- Presenilin C terminal fragment- Pen 2-RIGHT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment - r45
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1215
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1217
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1219
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1218
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1216
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1220
left: Presenilin N-terminal fragment
left: Nicastrin
left: Pen-2
left: Presenilin C-terminal fragment
left: Aph-1
display name: HETERODIMER_ASSOCIATION_LEFT__Nicastrin-_Presenilin_N_terminal_fragment-_Aph_1-_Presenilin_C_terminal_fragment-_Pen_2-RIGHT__Complex__Nicastrin_Aph_1__Pen_2_Presenilin_N_terminal_fragment__Presenilin_C_terminal_fragment_-_r45
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

Protein Wnt-5a
type: ProteinReference
xref: uniprot P22725 831
xref: PTHR12027:SF33
organism: Mus musculus

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68138 270
xref: PTHR11937:SF193
organism: Bos taurus

Protein Wnt-4
type: ProteinReference
xref: PTHR12027:SF101
xref: uniprot P22724 830
organism: Mus musculus

Actin, alpha skeletal muscle
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot P68139 271
organism: Gallus gallus

uniprot F0Z796 171
type: UnificationXref
id: F0Z796
db: uniprot

uniprot P28159 1017
type: UnificationXref
id: P28159
db: uniprot

uniprot P46531 450
type: UnificationXref
id: P46531
db: uniprot

Collagenase 3
type: ProteinReference
xref: PTHR10201:SF165
xref: uniprot G3V742 607
organism: Rattus norvegicus

Dishevelled segment polarity protein 2
type: ProteinReference
xref: uniprot F7BUW7 690
xref: PTHR10878:SF8
organism: Monodelphis domestica

ncbitaxon 8364 234
type: UnificationXref
id: 8364
db: ncbitaxon

AGAP002176-PA
type: ProteinReference
xref: uniprot Q7QK68 998
organism: Anopheles gambiae

PTHR11309:SF136
type: RelationshipXref
id: PTHR11309:SF136
db: PANTHER Family
relationship type: By Homology

uniprot P21552 829
type: UnificationXref
id: P21552
db: uniprot

PTHR11309:SF139
type: RelationshipXref
id: PTHR11309:SF139
db: PANTHER Family
relationship type: By Homology

Presenilin-2
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot Q61144 554
organism: Mus musculus

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot I2CYF0 210
organism: Macaca mulatta

Short transient receptor potential channel 6
type: ProteinReference
xref: uniprot Q61143 500
xref: PTHR10117:SF7
organism: Mus musculus

Beta-secretase 1
type: ProteinReference
xref: uniprot P56817 1027
xref: PTHR47965:SF69
organism: Homo sapiens

Matrix metallopeptidase 21
type: ProteinReference
xref: uniprot D3ZZ42 572
xref: PTHR10201:SF147
organism: Rattus norvegicus

Beta-secretase 1
type: ProteinReference
xref: PTHR47965:SF69
xref: uniprot P56818 1028
organism: Mus musculus

Giardia intestinalis
type: BioSource
xref: ncbitaxon 184922 117

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BDE8 1007
organism: Bos taurus

uniprot Q3ZC07 284
type: UnificationXref
id: Q3ZC07
db: uniprot

uniprot F6RKF7 376
type: UnificationXref
id: F6RKF7
db: uniprot

DISSOCIATION_LEFT__Complex__E_cadherin_beta_catenin__gammacatenin_alphacatenin__actin_-RIGHT__gammacatenin-_actin-_alphacatenin-_beta_catenin-_r29
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1278
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1276
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1277
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1279
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 1275
left: Complex (E-cadherin/beta-catenin/ gammacatenin/alphacatenin/ actin)
interaction type: DISSOCIATION
right: gammacatenin
right: beta-catenin
right: alphacatenin
right: actin

Notch C-terminal fragment
type: Protein
entity reference: Notch C-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa2 1160
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P10986 226
type: UnificationXref
id: P10986
db: uniprot

PTHR11309:SF140
type: RelationshipXref
id: PTHR11309:SF140
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF141
type: RelationshipXref
id: PTHR11309:SF141
db: PANTHER Family
relationship type: By Homology

Proprotein convertase subtilisin/kexin type 7
type: ProteinReference
xref: uniprot Q61139 993
organism: Mus musculus

Protein Wnt
type: ProteinReference
xref: uniprot C3XPR5 748
xref: PTHR12027:SF101
organism: Branchiostoma floridae

PTHR11937:SF201
type: RelationshipXref
id: PTHR11937:SF201
db: PANTHER Family
relationship type: By Homology

PTHR10615:SF183
type: RelationshipXref
id: PTHR10615:SF183
db: PANTHER Family
relationship type: By Homology

Neurogenic locus notch homolog protein 4
type: ProteinReference
xref: uniprot P31695 449
xref: PTHR24044:SF470
organism: Mus musculus

ADAM metallopeptidase domain 17
type: ProteinReference
xref: uniprot E1B867 914
xref: PTHR45702:SF6
organism: Bos taurus

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P60010 244
organism: Saccharomyces cerevisiae

uniprot Q5TP56 865
type: UnificationXref
id: Q5TP56
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF240
xref: uniprot F6XUU0 191
organism: Monodelphis domestica

Protein Wnt-7b
type: ProteinReference
xref: uniprot Q3L254 863
xref: PTHR12027:SF73
organism: Gallus gallus

Receptor tyrosine-protein kinase erbB-4
type: ProteinReference
xref: PTHR24416:SF90
xref: uniprot Q62956 93
organism: Rattus norvegicus

uniprot Q6GL68 901
type: UnificationXref
id: Q6GL68
db: uniprot

Furin
type: ProteinReference
xref: PTHR42884:SF1
xref: uniprot P23377 980
organism: Rattus norvegicus

uniprot P63269 261
type: UnificationXref
id: P63269
db: uniprot

uniprot F1QUN8 176
type: UnificationXref
id: F1QUN8
db: uniprot

Receptor protein-tyrosine kinase
type: ProteinReference
xref: uniprot F1P258 87
xref: PTHR24416:SF90
organism: Gallus gallus

ncbitaxon 665079 108
type: UnificationXref
id: 665079
db: ncbitaxon

Notch extracellular fragment
type: ProteinReference
xref: P00179
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Notch_br_extracellular_br_fragment
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Notch 4
member entity reference: Notch 3
member entity reference: Neurogenic locus Notch protein
member entity reference: Notch 1
member entity reference: NOTCH3 isoform 1
member entity reference: NOTCH1 isoform 1

Matrix metalloproteinase-25
type: ProteinReference
xref: uniprot Q9NPA2 658
xref: PTHR10201:SF142
organism: Homo sapiens

uniprot F7D527 671
type: UnificationXref
id: F7D527
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF102
xref: uniprot C3ZCG7 753
organism: Branchiostoma floridae

beta-catenin
type: Protein
entity reference: beta-catenin
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa12 1098
feature: beta catenin s46 sa12 rs2
feature: Ser beta catenin s46 sa12 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot Q6P640 305
organism: Xenopus tropicalis

uniprot P68035 266
type: UnificationXref
id: P68035
db: uniprot

Matrix metalloproteinase-27
type: ProteinReference
xref: uniprot Q9H306 656
xref: PTHR10201:SF115
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: uniprot E1BDG5 763
xref: PTHR12027:SF33
organism: Bos taurus

Frizzled class receptor 4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot E2RIL8 367
organism: Canis lupus familiaris

uniprot E1BEN9 764
type: UnificationXref
id: E1BEN9
db: uniprot

Os05g0106600 protein
type: ProteinReference
xref: PTHR11937:SF464
xref: uniprot Q65XH8 298
organism: Oryza sativa

uniprot Q9IA05 425
type: UnificationXref
id: Q9IA05
db: uniprot

Frizzled
type: ProteinReference
xref: P00119
comment: ENTITY_REFERENCE_NOTES=Long Name: Frizzled Synonym: Synonym not specified Accession: P00119
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.RECEPTOR.Frizzled
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Frizzled 8a protein
member entity reference: Frizzled-5
member entity reference: Frizzled class receptor 10
member entity reference: Frizzled class receptor 8
member entity reference: FZD10 isoform 2
member entity reference: Frizzled class receptor 6
member entity reference: Frizzled-4
member entity reference: Uncharacterized protein
member entity reference: Frizzled-3
member entity reference: Frizzled-1
member entity reference: Frizzled-9
member entity reference: AGAP010442-PA
member entity reference: Frizzled-6
member entity reference: Frizzled-7
member entity reference: Frizzled-10
member entity reference: Frizzled class receptor 9b
member entity reference: FZD5 isoform 1
member entity reference: Frizzled-2
member entity reference: Frizzled-8
member entity reference: FZD1 protein
member entity reference: Frizzled class receptor 4
member entity reference: Frizzled class receptor 5
member entity reference: FZD3 isoform 1
member entity reference: Frizzled class receptor 3
member entity reference: FZD9 isoform 1
member entity reference: Frizzled
member entity reference: Frizzled class receptor 2
member entity reference: Frizzled class receptor 9
member entity reference: Frizzled class receptor 7a
member entity reference: FZD7 isoform 1
member entity reference: FZD10 protein
member entity reference: Frizzled class receptor 7

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot A0A2J8LQ70 738
organism: Pan troglodytes

uniprot A8WV58 745
type: UnificationXref
id: A8WV58
db: uniprot

uniprot P48994 496
type: UnificationXref
id: P48994
db: uniprot

Lymphoid enhancer-binding factor 1
type: ProteinReference
xref: uniprot Q9QXN1 905
xref: PTHR10373:SF11
organism: Rattus norvegicus

uniprot F7BXC9 1011
type: UnificationXref
id: F7BXC9
db: uniprot

uniprot O14905 819
type: UnificationXref
id: O14905
db: uniprot

Alzheimer disease-presenilin pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_r32
pathway component: MODULATION
pathway component: TRUNCATION_LEFT__Complex__Nectin_1alpha_Afadin__alphacatenin_actin__beta_catenin_gammacatenin__E_cadherin_-RIGHT__Nectin_1alpha_C_terminal_fragment-_Nectin_1alpha_N_terminal_fragment-_r61
pathway component: TRANSPORT_LEFT__beta_catenin-RIGHT__beta_catenin-_r81
pathway component: TRUNCATION_LEFT__Notch_transmembrane_fragment-RIGHT__Notch_fragment-_NICD-_r4
pathway component: HETERODIMER ASSOCIATION LEFT Nicastrin- Presenilin N terminal fragment- Aph 1- Presenilin C terminal fragment- Pen 2-RIGHT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment - r45
pathway component: TRUNCATION_LEFT__Pro_BACE_1-RIGHT__BACE_1-_BACE_1_pro_domain-_r43
pathway component: TRUNCATION_LEFT__Presenilin-RIGHT__Presenilin_N_terminal_fragment-_Presenilin_C_terminal_fragment-_r44
pathway component: STATE_TRANSITION_LEFT__Dsh-RIGHT__Dsh-_r71
pathway component: TRUNCATION_LEFT__Notch-RIGHT__Notch_C_terminal_fragment-_Notch_N_terminal_fragment-_r1
pathway component: STATE_TRANSITION_LEFT__Ire_1-RIGHT__Ire_1-_r37
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__AICD_Fe65_-_Tip60-RIGHT__Complex__AICD_Fe65__Tip60_-_r52
pathway component: TRANSPORT_LEFT__Ire_1_C_terminal_fragment-RIGHT__Ire_1_C_terminal_fragment-_r74
pathway component: DISSOCIATION_LEFT__Complex__Nectin_1alpha_Afadin__alphacatenin_actin__beta_catenin_gammacatenin__E_cadherin_-RIGHT__gammacatenin-_actin-_E_cadherin-_alphacatenin-_beta_catenin-_Afadin-_r64
pathway component: HETERODIMER ASSOCIATION LEFT Complex Nectin 1alpha Afadin - Complex E cadherin beta catenin gammacatenin alphacatenin actin -RIGHT Complex Nectin 1alpha Afadin alphacatenin actin beta catenin gammacatenin E cadherin - r60
pathway component: TRUNCATION_LEFT__Nectin_1alpha_C_terminal_fragment-RIGHT__Nectin_1alpha_intracellular_fragment-_Nectin_1alpha_transmembrane_fragment-_r63
pathway component: TRUNCATION_LEFT__Complex__C99_Fe65_-RIGHT__Complex__AICD_Fe65_-_Abeta-_r50
pathway component: TRANSPORT LEFT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment -RIGHT Complex Nicastrin Aph 1 Pen 2 Presenilin N terminal fragment Presenilin C terminal fragment - r82
pathway component: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_r31
pathway component: HETERODIMER_ASSOCIATION_LEFT__Fe65-_LRP_intracellular_fragment-RIGHT__Complex__LRP_intracellular_fragment_Fe65_-_r25
pathway component: TRANSPORT_LEFT__CD44_intracellular_fragment-RIGHT__CD44_intracellular_fragment-_r78
pathway component: TRUNCATION_LEFT__Complex__APP_Fe65_-RIGHT__Complex__C99_Fe65_-_APPbeta-_r51
pathway component: TRUNCATION_LEFT__LRP-RIGHT__LRP_N_terminal_fragment-_LRP_C_terminal_fragment-_r23
pathway component: TRANSPORT_LEFT__Complex__LRP_intracellular_fragment_Fe65_-RIGHT__Complex__LRP_intracellular_fragment_Fe65_-_r79
pathway component: HETERODIMER_ASSOCIATION_LEFT__NICD-_CSL-RIGHT__Complex__CSL_NICD_-_r7
pathway component: TRUNCATION_LEFT__Erb_B4-RIGHT__Erb_B4_C_terminal_fragment-_Erb_B4_N_terminal_fragment-_r15
pathway component: STATE_TRANSITION_LEFT__Capacitative_calcium_channels-RIGHT__Capacitative_calcium_channels-_re56
pathway component: TRANSPORT_LEFT__Erb_B4_intracellular_fragment-RIGHT__Erb_B4_intracellular_fragment-_r77
pathway component: TRANSPORT_LEFT__Nectin_1alpha_intracellular_fragment-RIGHT__Nectin_1alpha_intracellular_fragment-_r80
pathway component: TRUNCATION_LEFT__Erb_B4_C_terminal_fragment-RIGHT__Erb_B4_transmembrane_fragment-_Erb_B4_intracellular_fragment-_r16
pathway component: STATE_TRANSITION_LEFT__GSK_3beta-RIGHT__GSK_3beta-_re55
pathway component: TRUNCATION_LEFT__E_cadherin_C_terminal_fragment-RIGHT__E_cadherin_intracellular_fragment-_E_cadherin_transmembrane_fragment-_r59
pathway component: TRUNCATION_LEFT__CD44-RIGHT__CD44_C_terminal_fragment-_CD44_N_terminal_fragment-_r19
pathway component: HETERODIMER_ASSOCIATION_LEFT__Wnt-_Frizzled-RIGHT__Complex__Wnt_Frizzled_-_r70
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r42
pathway component: TRUNCATION_LEFT__Complex__Notch_N_terminal_fragment_Notch_C_terminal_fragment_-RIGHT__Notch_transmembrane_fragment-_Complex__Notch_N_terminal_fragment_Notch_extracellular_fragment_-_r5
pathway component: HETERODIMER_ASSOCIATION_LEFT__Fe65-_APP-RIGHT__Complex__APP_Fe65_-_r48
pathway component: TRUNCATION_LEFT__Ire_1-RIGHT__Ire_1_N_terminal_fragment-_Ire_1_C_terminal_fragment-_r38
pathway component: HETERODIMER_ASSOCIATION_LEFT__TCF_LEF-_beta_catenin-RIGHT__Complex__beta_catenin_TCF__LEF_-_r67
pathway component: STATE_TRANSITION_LEFT__HAC1-RIGHT__HAC1-_r39
pathway component: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__a153_degraded-_r33
pathway component: TRANSPORT_LEFT__Complex__AICD_Fe65_-RIGHT__Complex__AICD_Fe65_-_r76
pathway component: TRANSPORT_LEFT__NICD-RIGHT__NICD-_r75
pathway component: TRUNCATION_LEFT__CD44_C_terminal_fragment-RIGHT__CD44_transmembrane_fragment-_CD44_intracellular_fragment-_r20
pathway component: TRUNCATION_LEFT__LRP_C_terminal_fragment-RIGHT__LRP_transmembrane_fragment-_LRP_intracellular_fragment-_r24
pathway component: HETERODIMER_ASSOCIATION_LEFT__Notch_C_terminal_fragment-_Notch_N_terminal_fragment-RIGHT__Complex__Notch_N_terminal_fragment_Notch_C_terminal_fragment_-_r2
pathway component: TRUNCATION_LEFT__Complex__E_cadherin_beta_catenin__gammacatenin_alphacatenin__actin_-RIGHT__E_cadherin_C_terminal_fragment-_E_cadherin_N_terminal_fragment-_r28
pathway component: DISSOCIATION_LEFT__Complex__E_cadherin_beta_catenin__gammacatenin_alphacatenin__actin_-RIGHT__gammacatenin-_actin-_alphacatenin-_beta_catenin-_r29
xref: PANTHER Pathway P00004 1
comment: MODEL_NOTES=Panther Pathway: P00004 The presenilin gamma-secretase complex (consisting of presenilin, nicastrin, Aph-1 and Pen-2) has been demonstrated to cleave several single-transmembrane proteins within the membrane domain, including the amyloid precursor protein, Notch, ErbB4, E-cadherin, Nectin-1alpha, and CD44. This cleavage only occurs sequentially after an inital cleavage on the extracellular side of the transmembrane domain by an alternate enzyme. Cleavage of APP by gamma-secretase after beta-secretase cleavage yields Abeta, the backbone of senile plaques in Alzheimer's disease, and an intracellular fragment capable of nuclear translocation and subsequent effects on gene transcription. Similarly, presenilin-mediated cleavage of Notch and ErbB4 yield intracellular fragments capable of signal transduction. Medline=12142279 Medline=12834808 Medline=14598312 PMID: 12142279 PMID: 12834808 PMID: 14598312

actin
type: Protein
entity reference: actin
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa15 1104
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

LDL receptor related protein 1B
type: ProteinReference
xref: uniprot F7B627 59
xref: PTHR22722:SF6
organism: Monodelphis domestica

uniprot A0A3Q2UCS9 1004
type: UnificationXref
id: A0A3Q2UCS9
db: uniprot

uniprot C3YKS6 155
type: UnificationXref
id: C3YKS6
db: uniprot

TACE
type: Protein
entity reference: TACE
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7DI28 791
type: UnificationXref
id: F7DI28
db: uniprot

Low-density lipoprotein receptor-related protein 3
type: ProteinReference
xref: uniprot O88204 76
xref: PTHR24270:SF22
organism: Rattus norvegicus

PTHR11309:SF126
type: RelationshipXref
id: PTHR11309:SF126
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r75 1229
type: Stoichiometry
physical entity: NICD
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: uniprot F1N4C0 773
xref: PTHR12027:SF7
organism: Bos taurus

uniprot Q2HJ40 1029
type: UnificationXref
id: Q2HJ40
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F6SF10 778
xref: PTHR12027:SF75
organism: Monodelphis domestica

Actin
type: ProteinReference
xref: uniprot Q9U1E8 324
organism: Leishmania major

Actin-related protein 2
type: ProteinReference
xref: uniprot P61161 251
xref: PTHR11937:SF37
organism: Mus musculus

ncbitaxon 10090 33
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot P20359 231
type: UnificationXref
id: P20359
db: uniprot

uniprot C3XZ13 153
type: UnificationXref
id: C3XZ13
db: uniprot

PARTICIPANT STOICHIOMETRY r75 1230
type: Stoichiometry
physical entity: NICD
stoichiometric coefficient: 1.0

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF409
xref: uniprot P61160 250
organism: Homo sapiens

ncbitaxon 7955 177
type: UnificationXref
id: 7955
db: ncbitaxon

Protein wingless
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot P09615 827
organism: Drosophila melanogaster

Tripartite motif-containing protein 3
type: ProteinReference
xref: uniprot Q9R1R2 679
organism: Mus musculus

uniprot Q9GZT5 875
type: UnificationXref
id: Q9GZT5
db: uniprot

Pen-2
type: ProteinReference
xref: P00149
standard name: Presenilin enhancer 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Pen-2
comment: ENTITY_REFERENCE_NOTES=Long Name: Presenilin enhancer 2 Synonym: Synonym not specified Accession: P00149
member entity reference: Gamma-secretase subunit pen-2
member entity reference: Gamma-secretase subunit PEN-2
member entity reference: Presenilin enhancer 2 homolog
member entity reference: AGAP008094-PA

Tip60
type: Protein
entity reference: Tip60
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 18

TRUNCATION_LEFT__Erb_B4-RIGHT__Erb_B4_C_terminal_fragment-_Erb_B4_N_terminal_fragment-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 1205
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 1207
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 1206
left: Erb-B4
interaction type: TRUNCATION
right: Erb-B4 N-terminal fragment
right: Erb-B4 C-terminal fragment

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot Q5M8T9 295
organism: Xenopus tropicalis

Matrix metalloproteinase-23
type: ProteinReference
xref: uniprot O88676 626
xref: PTHR10201:SF7
organism: Mus musculus

Protein Wnt
type: ProteinReference
xref: uniprot D4A3K6 759
xref: PTHR12027:SF70
organism: Rattus norvegicus

Notch 3
type: ProteinReference
xref: uniprot E1BPT8 439
xref: PTHR24033:SF176
organism: Bos taurus

Neurogenic locus notch homolog protein 1
type: ProteinReference
xref: uniprot P46531 450
xref: PTHR45836:SF12
organism: Homo sapiens

Matrix metalloproteinase-23
type: ProteinReference
xref: uniprot O88272 625
xref: PTHR10201:SF7
organism: Rattus norvegicus

ncbitaxon 36329 319
type: UnificationXref
id: 36329
db: ncbitaxon

Pen-2
type: Protein
entity reference: Pen-2
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Cadherin 3
type: ProteinReference
xref: PTHR24027:SF267
xref: uniprot F1LMI3 342
organism: Rattus norvegicus

Aph 1 s81 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Aph-1
stoichiometric coefficient: 1.0

PTHR13954:SF6
type: RelationshipXref
id: PTHR13954:SF6
db: PANTHER Family
relationship type: By Homology

Actin-2
type: ProteinReference
xref: uniprot A3C6D7 106
organism: Oryza sativa

Phagocytic glycoprotein I
type: ProteinReference
xref: uniprot F6ZDZ8 460
xref: PTHR10225:SF6
organism: Macaca mulatta

ncbitaxon 3702 30
type: UnificationXref
id: 3702
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NXB2 680
xref: PTHR10878:SF6
organism: Gallus gallus

DVL2 isoform 1
type: ProteinReference
xref: PTHR10878:SF8
xref: uniprot H2QC24 692
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r2 1212
type: Stoichiometry
physical entity: Notch C-terminal fragment
stoichiometric coefficient: 1.0

uniprot A0A2A6CRA8 99
type: UnificationXref
id: A0A2A6CRA8
db: uniprot

PARTICIPANT STOICHIOMETRY r31 1265
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 1213
type: Stoichiometry
physical entity: Notch N-terminal fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 1214
type: Stoichiometry
physical entity: Complex (Notch N-terminal fragment/Notch C-terminal fragment)
stoichiometric coefficient: 1.0

uniprot Q9QXQ7 880
type: UnificationXref
id: Q9QXQ7
db: uniprot

uniprot P07830 220
type: UnificationXref
id: P07830
db: uniprot

PARTICIPANT STOICHIOMETRY r31 1264
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

uniprot F7DNP7 931
type: UnificationXref
id: F7DNP7
db: uniprot

Frizzled class receptor 10
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot Q9W6E3 435
organism: Danio rerio

uniprot Q9YI00 436
type: UnificationXref
id: Q9YI00
db: uniprot

Protein Wnt-5a
type: ProteinReference
xref: uniprot Q9QXQ7 880
xref: PTHR12027:SF33
organism: Rattus norvegicus

uniprot P63267 259
type: UnificationXref
id: P63267
db: uniprot

Protein Wnt-4
type: ProteinReference
xref: uniprot Q9QXQ5 879
xref: PTHR12027:SF101
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF76
xref: uniprot A0A2J8LQ46 737
organism: Pan troglodytes

uniprot G7N677 65
type: UnificationXref
id: G7N677
db: uniprot

uniprot F6QP52 1023
type: UnificationXref
id: F6QP52
db: uniprot

uniprot Q9I9I2 878
type: UnificationXref
id: Q9I9I2
db: uniprot

uniprot A0A1D5RKL5 951
type: UnificationXref
id: A0A1D5RKL5
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF72
xref: uniprot F6WHM2 783
organism: Monodelphis domestica

Junction plakoglobin
type: ProteinReference
xref: uniprot Q6P0K8 935
xref: PTHR45976:SF3
organism: Rattus norvegicus

Frizzled-9
type: ProteinReference
xref: PTHR11309:SF79
xref: uniprot Q9R216 430
organism: Mus musculus

MMP8 isoform 1
type: ProteinReference
xref: uniprot H2Q4N0 612
xref: PTHR10201:SF137
organism: Pan troglodytes

MMP1 isoform 1
type: ProteinReference
xref: PTHR10201:SF151
xref: uniprot H2Q4N3 613
organism: Pan troglodytes

uniprot Q92542 338
type: UnificationXref
id: Q92542
db: uniprot

uniprot P53494 241
type: UnificationXref
id: P53494
db: uniprot

Interstitial collagenase
type: ProteinReference
xref: uniprot P03956 628
xref: PTHR10201:SF151
organism: Homo sapiens

PTHR10398:SF2
type: RelationshipXref
id: PTHR10398:SF2
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot C3XZ13 153
organism: Branchiostoma floridae

uniprot O70138 623
type: UnificationXref
id: O70138
db: uniprot

uniprot H2R900 916
type: UnificationXref
id: H2R900
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F6XUZ7 787
xref: PTHR12027:SF87
organism: Monodelphis domestica

uniprot F6Q5F4 961
type: UnificationXref
id: F6Q5F4
db: uniprot

uniprot K7BDV3 716
type: UnificationXref
id: K7BDV3
db: uniprot

Proteasome
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Anterior pharynx defective 1 homolog A
type: ProteinReference
xref: PTHR12889:SF3
xref: uniprot E2R5H5 1033
organism: Canis lupus familiaris

uniprot H2Q9J9 1035
type: UnificationXref
id: H2Q9J9
db: uniprot

uniprot P40589 841
type: UnificationXref
id: P40589
db: uniprot

uniprot H2QB81 616
type: UnificationXref
id: H2QB81
db: uniprot

Transient receptor potential cation channel subfamily C member 6
type: ProteinReference
xref: uniprot H2Q4M0 488
xref: PTHR10117:SF7
organism: Pan troglodytes

Histone acetyltransferase KAT7
type: ProteinReference
xref: uniprot Q5SVQ0 719
organism: Mus musculus

uniprot C3XYC4 146
type: UnificationXref
id: C3XYC4
db: uniprot

Nectin 1alpha C-terminal fragment
type: Protein
entity reference: Nectin 1alpha C-terminal fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MMP27 isoform 1
type: ProteinReference
xref: uniprot H2Q4M9 611
xref: PTHR10201:SF115
organism: Pan troglodytes

uniprot F6WBD5 941
type: UnificationXref
id: F6WBD5
db: uniprot

uniprot H2QJF8 808
type: UnificationXref
id: H2QJF8
db: uniprot

MMP7 isoform 1
type: ProteinReference
xref: uniprot H2Q4M7 609
xref: PTHR10201:SF143
organism: Pan troglodytes

Nicastrin
type: ProteinReference
xref: P00115
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Nicastrin
comment: ENTITY_REFERENCE_NOTES=Long Name: Nicastrin Synonym: Synonym not specified Accession: P00115
member entity reference: Nicastrin

MMP20 isoform 1
type: ProteinReference
xref: uniprot H2Q4M8 610
xref: PTHR10201:SF125
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot F7HRY3 691
organism: Macaca mulatta

uniprot F7D4J8 790
type: UnificationXref
id: F7D4J8
db: uniprot

Low-density lipoprotein receptor-related protein 4
type: ProteinReference
xref: PTHR24270:SF5
xref: uniprot O75096 73
organism: Homo sapiens

uniprot P51559 988
type: UnificationXref
id: P51559
db: uniprot

uniprot F7DUN9 484
type: UnificationXref
id: F7DUN9
db: uniprot

uniprot Q9W6T7 559
type: UnificationXref
id: Q9W6T7
db: uniprot

uniprot Q8RYC2 321
type: UnificationXref
id: Q8RYC2
db: uniprot

uniprot A0A2I3SXI2 1048
type: UnificationXref
id: A0A2I3SXI2
db: uniprot

Pro-BACE-1
type: Protein
entity reference: Pro-BACE-1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: PTHR10878:SF5
xref: uniprot Q9WVB9 701
organism: Rattus norvegicus

Junction plakoglobin
type: ProteinReference
xref: PTHR45976:SF3
xref: uniprot F7DNP7 931
organism: Monodelphis domestica

uniprot F1N4K7 371
type: UnificationXref
id: F1N4K7
db: uniprot

uniprot P51511 643
type: UnificationXref
id: P51511
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F7ALP1 195
organism: Monodelphis domestica

uniprot Q8L9G7 1044
type: UnificationXref
id: Q8L9G7
db: uniprot

PTHR10201:SF137
type: RelationshipXref
id: PTHR10201:SF137
db: PANTHER Family
relationship type: By Homology

Presenilin-1
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot P49768 547
organism: Homo sapiens

PTHR10201:SF138
type: RelationshipXref
id: PTHR10201:SF138
db: PANTHER Family
relationship type: By Homology

Presenilin-1
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot P49769 548
organism: Mus musculus

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r42
control type: ACTIVATION
controller: Capacitative calcium channels

uniprot Q5BL41 290
type: UnificationXref
id: Q5BL41
db: uniprot

uniprot Q8C7N7 1042
type: UnificationXref
id: Q8C7N7
db: uniprot

uniprot Q6P378 304
type: UnificationXref
id: Q6P378
db: uniprot

uniprot O35827 530
type: UnificationXref
id: O35827
db: uniprot

uniprot H2R817 810
type: UnificationXref
id: H2R817
db: uniprot

uniprot Q5BL72 409
type: UnificationXref
id: Q5BL72
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10201:SF29
xref: uniprot A0A1D5QTJ7 565
organism: Macaca mulatta

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot Q2QLE7 862
organism: Pan troglodytes

Frizzled class receptor 3
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot E2R9M9 365
organism: Canis lupus familiaris

Amyloid-beta A4 protein
type: ProteinReference
xref: PTHR23103:SF7
xref: uniprot P08592 40
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF84
xref: uniprot A0A3Q1M1A0 739
organism: Bos taurus

Protein Wnt-8c
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot P51030 851
organism: Gallus gallus

uniprot F7E9U1 385
type: UnificationXref
id: F7E9U1
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 16

Frizzled class receptor 6
type: ProteinReference
xref: uniprot G3V6L1 389
xref: PTHR11309:SF75
organism: Rattus norvegicus

uniprot F7B2E9 481
type: UnificationXref
id: F7B2E9
db: uniprot

uniprot Q9DEB8 874
type: UnificationXref
id: Q9DEB8
db: uniprot

uniprot Q9R244 510
type: UnificationXref
id: Q9R244
db: uniprot

uniprot P22726 832
type: UnificationXref
id: P22726
db: uniprot

PTHR10201:SF125
type: RelationshipXref
id: PTHR10201:SF125
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re55 1198
type: Stoichiometry
physical entity: GSK-3beta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re55 1199
type: Stoichiometry
physical entity: GSK-3beta
stoichiometric coefficient: 1.0

uniprot A4FTT3 1005
type: UnificationXref
id: A4FTT3
db: uniprot

Amyloid beta precursor protein binding family B member 2
type: ProteinReference
xref: uniprot F7APL6 526
organism: Monodelphis domestica

Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
type: Complex
component stoichiometry: Nicastrin s79 sa45 STOICHIOMETRY ID COMPLEX
component stoichiometry: Aph 1 s81 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pen 2 s82 sa47 STOICHIOMETRY ID COMPLEX
component stoichiometry: Presenilin C terminal fragment s86 sa49 STOICHIOMETRY ID COMPLEX
component stoichiometry: Presenilin N terminal fragment s84 sa48 STOICHIOMETRY ID COMPLEX
component: Nicastrin
component: Pen-2
component: Presenilin N-terminal fragment
component: Aph-1
component: Presenilin C-terminal fragment
feature: COMPLEX BINDING FEATURE s261 a251 1123
feature: COMPLEX BINDING FEATURE s261 a251 1127
feature: ACTIVE 517
feature: COMPLEX BINDING FEATURE s261 a251 1121
feature: COMPLEX BINDING FEATURE s261 a251 1129
feature: COMPLEX BINDING FEATURE s261 a251 1125
cellular location: cytosol

uniprot P35222 945
type: UnificationXref
id: P35222
db: uniprot

Proto-oncogene Wnt-1
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot P04628 825
organism: Homo sapiens

Protein Wnt-8b
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot P51029 850
organism: Danio rerio

Short transient receptor potential channel 4
type: ProteinReference
xref: PTHR10117:SF25
xref: uniprot O35119 494
organism: Rattus norvegicus

uniprot Q07008 452
type: UnificationXref
id: Q07008
db: uniprot

Protein Wnt-8a
type: ProteinReference
xref: PTHR12027:SF92
xref: uniprot P51028 849
organism: Danio rerio

Actin-1
type: ProteinReference
xref: uniprot Q8I4X0 318
organism: Plasmodium falciparum

uniprot Q6IQL9 302
type: UnificationXref
id: Q6IQL9
db: uniprot

uniprot F6TYA8 689
type: UnificationXref
id: F6TYA8
db: uniprot

BACE2 isoform 3
type: ProteinReference
xref: uniprot H2R1L7 1026
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r64 1258
type: Stoichiometry
physical entity: gammacatenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 1259
type: Stoichiometry
physical entity: actin
stoichiometric coefficient: 1.0

Actin-1
type: ProteinReference
xref: uniprot Q10DV7 281
organism: Oryza sativa

PTHR10201:SF151
type: RelationshipXref
id: PTHR10201:SF151
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
evidence: Evidence 564
xref: PTHR10201:SF165
xref: uniprot A0A1D5QFN4 563
organism: Macaca mulatta

Shaggy-related protein kinase epsilon
type: ProteinReference
xref: uniprot Q8VZD5 1067
organism: Arabidopsis thaliana

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: uniprot Q9CQR7 928
xref: PTHR16318:SF0
organism: Mus musculus

Furin, paired basic amino acid cleaving enzyme
type: ProteinReference
xref: uniprot F7CEB1 964
xref: PTHR42884:SF1
organism: Xenopus tropicalis

uniprot F1PU73 332
type: UnificationXref
id: F1PU73
db: uniprot

uniprot F7CXM3 482
type: UnificationXref
id: F7CXM3
db: uniprot

uniprot F7H767 967
type: UnificationXref
id: F7H767
db: uniprot

uniprot P46933 532
type: UnificationXref
id: P46933
db: uniprot

PARTICIPANT STOICHIOMETRY r64 1257
type: Stoichiometry
physical entity: Complex (Nectin 1alpha/Afadin/ alphacatenin/actin/ beta-catenin/gammacatenin/ E-cadherin)
stoichiometric coefficient: 1.0

uniprot P23377 980
type: UnificationXref
id: P23377
db: uniprot

Dishevelled segment polarity protein 2
type: ProteinReference
xref: uniprot D3ZB71 683
xref: PTHR10878:SF8
organism: Rattus norvegicus

uniprot B3DIG4 362
type: UnificationXref
id: B3DIG4
db: uniprot

Short transient receptor potential channel 7
type: ProteinReference
xref: uniprot Q9WVC5 515
xref: PTHR10117:SF9
organism: Mus musculus

Amyloid-beta A4 precursor protein-binding family B member 2
type: ProteinReference
xref: uniprot Q9DBR4 535
organism: Mus musculus

Complex (LRP intracellular fragment/Fe65)
type: Complex
component stoichiometry: Fe65 s10 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: LRP intracellular fragment s9 sa9 STOICHIOMETRY ID COMPLEX
component: Fe65
component: LRP intracellular fragment
feature: COMPLEX BINDING FEATURE s85 a88 1167
feature: COMPLEX BINDING FEATURE s85 a88 1165
cellular location: nucleus

uniprot Q2QLE7 862
type: UnificationXref
id: Q2QLE7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot F1N4K7 371
organism: Bos taurus

PTHR10201:SF143
type: RelationshipXref
id: PTHR10201:SF143
db: PANTHER Family
relationship type: By Homology

PTHR10201:SF142
type: RelationshipXref
id: PTHR10201:SF142
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9258 61
type: UnificationXref
id: 9258
db: ncbitaxon

ACTIVE 517
type: EntityFeature
comment: Active state

Neurogenic locus notch homolog protein 2
type: ProteinReference
xref: uniprot O35516 447
xref: PTHR22804:SF52
organism: Mus musculus

Matrix metallopeptidase 2
type: ProteinReference
xref: PTHR10201:SF29
xref: uniprot F1MKH8 575
organism: Bos taurus

Proprotein convertase subtilisin/kexin type 7
type: ProteinReference
xref: uniprot E2REE0 956
organism: Canis lupus familiaris

Short transient receptor potential channel 4
type: ProteinReference
xref: PTHR10117:SF25
xref: uniprot P79100 498
organism: Bos taurus

PTHR10201:SF147
type: RelationshipXref
id: PTHR10201:SF147
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: uniprot D3ZF63 755
xref: PTHR12027:SF75
organism: Rattus norvegicus

AICD
type: Protein
entity reference: AICD
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa38 1106
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Membrane metalloprotease
type: Protein
entity reference: Membrane metalloprotease
comment: SPECIES_TYPE=PROTEIN

uniprot F7EU36 199
type: UnificationXref
id: F7EU36
db: uniprot

beta catenin s46 sa12 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot F7FDA8 672
type: UnificationXref
id: F7FDA8
db: uniprot

E-cadherin transmembrane fragment
type: ProteinReference
xref: P00139
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.E-cadherin_br_transmembrane_br_fragment
comment: ENTITY_REFERENCE_NOTES=Long Name: E-cadherin transmembrane fragment Synonym: Synonym not specified Accession: P00139
member entity reference: Cadherin-1
member entity reference: Cadherin-3
member entity reference: Cadherin 3
member entity reference: Uncharacterized protein
member entity reference: CDH1 isoform 1
member entity reference: Cadherin 1, type 1, E-cadherin (epithelial)
member entity reference: CDH3 isoform 2

Nectin 1alpha N-terminal fragment
type: ProteinReference
xref: P00164
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Nectin 1_alpha__br_N-terminal_br_fragment
comment: ENTITY_REFERENCE_NOTES=Long Name: Nectin 1alpha N-terminal fragment Synonym: Synonym not specified Accession: P00164
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: Nectin cell adhesion molecule 1
member entity reference: Nectin-1
member entity reference: Uncharacterized protein

uniprot P62739 254
type: UnificationXref
id: P62739
db: uniprot

Matrix metallopeptidase 16
type: ProteinReference
xref: uniprot A0A2I3SEA5 566
xref: PTHR10201:SF26
organism: Pan troglodytes

uniprot F1MFR6 959
type: UnificationXref
id: F1MFR6
db: uniprot

Matrix metalloproteinase-19
type: ProteinReference
xref: uniprot Q99542 654
xref: PTHR10201:SF166
organism: Homo sapiens

Puccinia graminis
type: BioSource
xref: ncbitaxon 418459 165

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YVM2 594
xref: PTHR10201:SF267
organism: Macaca mulatta

Actin
type: ProteinReference
xref: uniprot P90623 277
organism: Trichomonas vaginalis

Junction plakoglobin
type: ProteinReference
xref: uniprot Q02257 934
xref: PTHR45976:SF3
organism: Mus musculus

uniprot Q55EU6 287
type: UnificationXref
id: Q55EU6
db: uniprot

Aph-1 homolog A, gamma-secretase subunit
type: ProteinReference
xref: PTHR12889:SF3
xref: uniprot F7ADK5 1034
organism: Monodelphis domestica

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot O88766 627
type: UnificationXref
id: O88766
db: uniprot

uniprot A0A3Q1MZ99 891
type: UnificationXref
id: A0A3Q1MZ99
db: uniprot

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 119

Frizzled-3
type: ProteinReference
xref: uniprot Q9NPG1 427
xref: PTHR11309:SF22
organism: Homo sapiens

Complex (Nectin 1alpha/Afadin/ alphacatenin/actin/ beta-catenin/gammacatenin/ E-cadherin)
type: Complex
component stoichiometry: alphacatenin s57 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: gammacatenin s67 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: Afadin s54 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: actin s58 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: E cadherin s68 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: Nectin 1alpha s50 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: beta catenin s61 sa22 STOICHIOMETRY ID COMPLEX
component: Afadin
component: actin
component: E-cadherin
component: gammacatenin
component: Nectin 1alpha
component: beta-catenin
component: alphacatenin
feature: COMPLEX BINDING FEATURE s120 a151 1135
feature: COMPLEX BINDING FEATURE s120 a151 1143
feature: COMPLEX BINDING FEATURE s120 a151 1141
feature: COMPLEX BINDING FEATURE s120 a151 1133
feature: COMPLEX BINDING FEATURE s120 a151 1137
feature: COMPLEX BINDING FEATURE s120 a151 1139
feature: COMPLEX BINDING FEATURE s120 a151 1131
cellular location: cytosol

uniprot C3XYD3 151
type: UnificationXref
id: C3XYD3
db: uniprot

uniprot A0A2I3SB38 518
type: UnificationXref
id: A0A2I3SB38
db: uniprot

PTHR10201:SF165
type: RelationshipXref
id: PTHR10201:SF165
db: PANTHER Family
relationship type: By Homology

uniprot F6ZPQ4 192
type: UnificationXref
id: F6ZPQ4
db: uniprot

PTHR10117:SF6
type: RelationshipXref
id: PTHR10117:SF6
db: PANTHER Family
relationship type: By Homology

Protein Wnt (Fragment)
type: ProteinReference
xref: PTHR12027:SF81
xref: uniprot C3XYW6 749
organism: Branchiostoma floridae

PTHR10117:SF7
type: RelationshipXref
id: PTHR10117:SF7
db: PANTHER Family
relationship type: By Homology

PTHR10117:SF8
type: RelationshipXref
id: PTHR10117:SF8
db: PANTHER Family
relationship type: By Homology

AICD
type: Protein
entity reference: AICD
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa34 1150
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR10117:SF9
type: RelationshipXref
id: PTHR10117:SF9
db: PANTHER Family
relationship type: By Homology

uniprot Q9QZQ1 913
type: UnificationXref
id: Q9QZQ1
db: uniprot

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot Q23316 335
organism: Caenorhabditis elegans

Actin-10
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot Q54GX7 285
organism: Dictyostelium discoideum

uniprot Q8R5M2 869
type: UnificationXref
id: Q8R5M2
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF7
xref: uniprot E2QXQ3 766
organism: Canis lupus familiaris

PTHR10201:SF166
type: RelationshipXref
id: PTHR10201:SF166
db: PANTHER Family
relationship type: By Homology

uniprot O75900 624
type: UnificationXref
id: O75900
db: uniprot

Catenin beta-1
type: ProteinReference
xref: uniprot Q02248 946
xref: PTHR45976:SF4
organism: Mus musculus

Major actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P07830 220
organism: Dictyostelium discoideum

HETERODIMER ASSOCIATION LEFT Complex Nectin 1alpha Afadin - Complex E cadherin beta catenin gammacatenin alphacatenin actin -RIGHT Complex Nectin 1alpha Afadin alphacatenin actin beta catenin gammacatenin E cadherin - r60
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1273
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1274
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1272
left: Complex (E-cadherin/beta-catenin/ gammacatenin/alphacatenin/ actin)
left: Complex (Nectin 1alpha/Afadin)
display name: HETERODIMER_ASSOCIATION_LEFT__Complex__Nectin_1alpha_Afadin_-_Complex__E_cadherin_beta_catenin__gammacatenin_alphacatenin__actin_-RIGHT__Complex__Nectin_1alpha_Afadin__alphacatenin_actin__beta_catenin_gammacatenin__E_cadherin_-_r60
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Nectin 1alpha/Afadin/ alphacatenin/actin/ beta-catenin/gammacatenin/ E-cadherin)

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot F1MFR6 959
organism: Bos taurus

Protein Wnt-2b
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot O70283 821
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LTG6 468
xref: PTHR10117:SF9
organism: Bos taurus

uniprot F1PXA0 54
type: UnificationXref
id: F1PXA0
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot A0A1D5NX70 732
organism: Gallus gallus

Furin
type: ProteinReference
xref: P00157
comment: ENTITY_REFERENCE_NOTES=Long Name: Furin Synonym: Synonym not specified Accession: P00157
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Furin
member entity reference: Proprotein convertase subtilisin/kexin type 2
member entity reference: PCSK2 isoform 2
member entity reference: Proprotein convertase subtilisin/kexin type 7
member entity reference: Furin
member entity reference: Neuroendocrine convertase 1
member entity reference: Proprotein convertase subtilisin/kexin type 6
member entity reference: PCSK1 isoform 2
member entity reference: Furin-like protease kpc-1
member entity reference: Neuroendocrine convertase 2
member entity reference: Proprotein convertase subtilisin/kexin type 1
member entity reference: Endoprotease bli-4
member entity reference: Proprotein convertase subtilisin/kexin type 4
member entity reference: Furin, paired basic amino acid cleaving enzyme
member entity reference: Uncharacterized protein
member entity reference: Amontillado
member entity reference: Trans Golgi network protease furin
member entity reference: Dibasic-processing endoprotease
member entity reference: Neuroendocrine convertase 1 isoform 1 preproprotein
member entity reference: Neuroendocrine convertase 2 isoform 1 preproprotein
member entity reference: Proprotein convertase subtilisin/kexin type 5
member entity reference: Furin-like protease 1, isoforms 1/1-X/2
member entity reference: Furin-like protease 2
member entity reference: FURIN isoform 1
member entity reference: AGAP002176-PA

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__a153_degraded-_r33
controller: Proteasome

uniprot Q9QXN1 905
type: UnificationXref
id: Q9QXN1
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 121

uniprot D3ZRW5 758
type: UnificationXref
id: D3ZRW5
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 213

Actin-3
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot P07829 219
organism: Dictyostelium discoideum

Notch fragment
type: Protein
entity reference: Notch fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Actin-18
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot P07828 217
organism: Dictyostelium discoideum

Tripartite motif-containing protein 3
type: ProteinReference
xref: uniprot O70277 673
organism: Rattus norvegicus

Pristionchus pacificus
type: BioSource
xref: ncbitaxon 54126 100

uniprot P68139 271
type: UnificationXref
id: P68139
db: uniprot

uniprot Q06330 1019
type: UnificationXref
id: Q06330
db: uniprot

Afadin
type: Protein
entity reference: Afadin
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa19 1134
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot F7GL73 202
organism: Monodelphis domestica

TRANSPORT_LEFT__Ire_1_C_terminal_fragment-RIGHT__Ire_1_C_terminal_fragment-_r74
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 1235
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 1234
left: Ire-1 C-terminal fragment
interaction type: TRANSPORT
right: Ire-1 C-terminal fragment

APH1B isoform 1
type: ProteinReference
xref: PTHR12889:SF1
xref: uniprot H2Q9J9 1035
organism: Pan troglodytes

PTHR42884:SF23
type: RelationshipXref
id: PTHR42884:SF23
db: PANTHER Family
relationship type: By Homology

Receptor tyrosine-protein kinase erbB-4
type: ProteinReference
xref: uniprot Q15303 91
xref: PTHR24416:SF90
organism: Homo sapiens

uniprot A0A0D1DMT3 94
type: UnificationXref
id: A0A0D1DMT3
db: uniprot

LRP intracellular fragment s7 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LRP intracellular fragment
stoichiometric coefficient: 1.0

uniprot D3ZCG5 570
type: UnificationXref
id: D3ZCG5
db: uniprot

uniprot F1PDC7 440
type: UnificationXref
id: F1PDC7
db: uniprot

Tip60
type: ProteinReference
xref: P00137
standard name: HIV-1 Tat interactive protein, 60kDa
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: HIV-1 Tat interactive protein, 60kDa Synonym: HTATIP1,PLIP,TIP,TIP60,cPLA2 Accession: P00137
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Tip60
member entity reference: Histone acetyltransferase KAT7
member entity reference: Histone acetyltransferase
member entity reference: Histone acetyltransferase KAT5

Ser beta catenin s131 a164 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Ser
feature location: Ser beta catenin s131 a164 rs1 Ser
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=Ser

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa8 1164
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7FK62 794
type: UnificationXref
id: F7FK62
db: uniprot

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: uniprot F7F4W9 201
xref: PTHR11937:SF201
organism: Ornithorhynchus anatinus

uniprot P68133 267
type: UnificationXref
id: P68133
db: uniprot

uniprot O70277 673
type: UnificationXref
id: O70277
db: uniprot

uniprot A0A3Q1M1A0 739
type: UnificationXref
id: A0A3Q1M1A0
db: uniprot

Notch N terminal fragment s42 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Notch N-terminal fragment
stoichiometric coefficient: 1.0

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7SCN8 113
organism: Nematostella vectensis

Presenilin C terminal fragment s86 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin C-terminal fragment
stoichiometric coefficient: 1.0

uniprot P07207 448
type: UnificationXref
id: P07207
db: uniprot

Amyloid-beta A4 precursor protein-binding family B member 1
type: ProteinReference
xref: uniprot Q9QXJ1 536
xref: PTHR14058:SF5
organism: Mus musculus

uniprot Q10739 649
type: UnificationXref
id: Q10739
db: uniprot

uniprot Q10452 1063
type: UnificationXref
id: Q10452
db: uniprot

uniprot Q9W6E3 435
type: UnificationXref
id: Q9W6E3
db: uniprot

uniprot F7F4W9 201
type: UnificationXref
id: F7F4W9
db: uniprot

uniprot F1MTK6 576
type: UnificationXref
id: F1MTK6
db: uniprot

uniprot Q9VBC7 1000
type: UnificationXref
id: Q9VBC7
db: uniprot

Beta-secretase 1
type: ProteinReference
xref: PTHR47965:SF69
xref: uniprot H2Q4U8 1025
organism: Pan troglodytes

uniprot P18824 944
type: UnificationXref
id: P18824
db: uniprot

uniprot Q9Y6F9 885
type: UnificationXref
id: Q9Y6F9
db: uniprot

uniprot E2QV83 1008
type: UnificationXref
id: E2QV83
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot H2Q569 806
xref: PTHR12027:SF87
organism: Pan troglodytes

uniprot Q9R1R2 679
type: UnificationXref
id: Q9R1R2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC6 148
xref: PTHR11937:SF468
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC5 147
xref: PTHR11937:SF468
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC8 150
xref: PTHR11937:SF468
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC7 149
organism: Branchiostoma floridae

P00139
type: UnificationXref
id: P00139
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC2 143
xref: PTHR11937:SF468
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F147 599
xref: PTHR10201:SF25
organism: Macaca mulatta

P00137
type: UnificationXref
id: P00137
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC4 146
xref: PTHR11937:SF468
organism: Branchiostoma floridae

uniprot Q5G235 923
type: UnificationXref
id: Q5G235
db: uniprot

P00136
type: UnificationXref
id: P00136
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC3 145
organism: Branchiostoma floridae

PTHR24033:SF188
type: RelationshipXref
id: PTHR24033:SF188
db: PANTHER Family
relationship type: By Homology

Presenilin C terminal fragment s20 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin C-terminal fragment
stoichiometric coefficient: 1.0

Matrix metalloproteinase-24
type: ProteinReference
xref: uniprot Q99PW6 726
organism: Rattus norvegicus

uniprot G7ME71 333
type: UnificationXref
id: G7ME71
db: uniprot

MMP9 isoform 1
type: ProteinReference
xref: uniprot H2QKI0 618
xref: PTHR10201:SF30
organism: Pan troglodytes

STATE_TRANSITION_LEFT__beta_catenin-RIGHT__a153_degraded-_r33
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1253
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1254
left: beta-catenin
interaction type: STATE_TRANSITION
right: a153_degraded

uniprot P53478 237
type: UnificationXref
id: P53478
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__Notch_N_terminal_fragment_Notch_C_terminal_fragment_-RIGHT__Notch_transmembrane_fragment-_Complex__Notch_N_terminal_fragment_Notch_extracellular_fragment_-_r5
controller: TACE

Dishevelled segment polarity protein 3
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot F6TYA8 689
organism: Monodelphis domestica

Actin, alpha 1, skeletal muscle
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot Q6DIV8 301
organism: Xenopus tropicalis

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot A4D7S0 741
organism: Bos taurus

Nectin 1alpha
type: ProteinReference
xref: P00160
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Nectin 1_alpha_
member entity reference: Nectin cell adhesion molecule 1
member entity reference: Nectin-1
member entity reference: Uncharacterized protein

LRP intracellular fragment
type: Protein
entity reference: LRP intracellular fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Transient receptor potential cation channel, subfamily C, member 7
type: ProteinReference
xref: uniprot F1LQF7 471
xref: PTHR10117:SF9
organism: Rattus norvegicus

Endoplasmic reticulum to nucleus-signaling 1
type: ProteinReference
xref: uniprot A0A0G2K2H4 6
xref: PTHR13954:SF17
organism: Rattus norvegicus

Amyloid beta precursor protein binding family B member 3
type: ProteinReference
xref: uniprot A0A2I3TC20 519
organism: Pan troglodytes

uniprot F1P476 175
type: UnificationXref
id: F1P476
db: uniprot

uniprot A0A2I3TNC3 459
type: UnificationXref
id: A0A2I3TNC3
db: uniprot

E cadherin s45 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: E-cadherin
stoichiometric coefficient: 1.0

Neuroendocrine convertase 1 isoform 1 preproprotein
type: ProteinReference
xref: uniprot H9FVB9 974
organism: Macaca mulatta

Frizzled-5
type: ProteinReference
xref: uniprot Q13467 406
xref: PTHR11309:SF136
organism: Homo sapiens

uniprot A9TYG6 131
type: UnificationXref
id: A9TYG6
db: uniprot

P00145
type: UnificationXref
id: P00145
db: PANTHER Pathway Component

P00146
type: UnificationXref
id: P00146
db: PANTHER Pathway Component

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 293

P00143
type: UnificationXref
id: P00143
db: PANTHER Pathway Component

P00144
type: UnificationXref
id: P00144
db: PANTHER Pathway Component

P00141
type: UnificationXref
id: P00141
db: PANTHER Pathway Component

uniprot F7ACT4 1053
type: UnificationXref
id: F7ACT4
db: uniprot

P00142
type: UnificationXref
id: P00142
db: PANTHER Pathway Component

Shaggy-related protein kinase theta
type: ProteinReference
xref: uniprot Q96287 1069
organism: Arabidopsis thaliana

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot E2RB53 1051
xref: PTHR24057:SF8
organism: Canis lupus familiaris

P00140
type: UnificationXref
id: P00140
db: PANTHER Pathway Component

P00129
type: UnificationXref
id: P00129
db: PANTHER Pathway Component

uniprot Q9H461 424
type: UnificationXref
id: Q9H461
db: uniprot

P00126
type: UnificationXref
id: P00126
db: PANTHER Pathway Component

Complex (LRP intracellular fragment/Fe65)
type: Complex
component stoichiometry: Fe65 s8 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: LRP intracellular fragment s7 sa7 STOICHIOMETRY ID COMPLEX
component: LRP intracellular fragment
component: Fe65
feature: COMPLEX BINDING FEATURE s83 a86 1161
feature: COMPLEX BINDING FEATURE s83 a86 1163
cellular location: cytosol

P00125
type: UnificationXref
id: P00125
db: PANTHER Pathway Component

uniprot F1PSU6 910
type: UnificationXref
id: F1PSU6
db: uniprot

PTHR24033:SF176
type: RelationshipXref
id: PTHR24033:SF176
db: PANTHER Family
relationship type: By Homology

P00128
type: UnificationXref
id: P00128
db: PANTHER Pathway Component

P00127
type: UnificationXref
id: P00127
db: PANTHER Pathway Component

Matrix metallopeptidase 13
type: ProteinReference
evidence: Evidence 578
xref: PTHR10201:SF165
xref: uniprot F1PVS9 583
organism: Canis lupus familiaris

Lin-12 And Glp-1 phenotype
type: ProteinReference
xref: PTHR10665:SF0
xref: uniprot V6CLJ5 1022
organism: Caenorhabditis elegans

uniprot Q08464 405
type: UnificationXref
id: Q08464
db: uniprot

NOTCH1 isoform 1
type: ProteinReference
xref: PTHR45836:SF12
xref: uniprot H2QY65 445
organism: Pan troglodytes

Frizzled class receptor 6
type: ProteinReference
xref: uniprot F1MP23 370
xref: PTHR11309:SF75
organism: Bos taurus

Actin-2
type: ProteinReference
xref: uniprot Q96292 322
organism: Arabidopsis thaliana

beta catenin s121 a152 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

P00132
type: UnificationXref
id: P00132
db: PANTHER Pathway Component

P00134
type: UnificationXref
id: P00134
db: PANTHER Pathway Component

P00135
type: UnificationXref
id: P00135
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r67 1250
type: Stoichiometry
physical entity: TCF/LEF
stoichiometric coefficient: 1.0

Actin 1
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q6TYS2 307
organism: Physcomitrella patens

PARTICIPANT STOICHIOMETRY r67 1251
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 144

P00130
type: UnificationXref
id: P00130
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r67 1252
type: Stoichiometry
physical entity: Complex (beta-catenin/TCF/ LEF)
stoichiometric coefficient: 1.0

P00131
type: UnificationXref
id: P00131
db: PANTHER Pathway Component

Actin, cytoplasmic 2
type: ProteinReference
xref: uniprot Q5ZMQ2 297
xref: PTHR11937:SF414
organism: Gallus gallus

P00117
type: UnificationXref
id: P00117
db: PANTHER Pathway Component

P00115
type: UnificationXref
id: P00115
db: PANTHER Pathway Component

P00114
type: UnificationXref
id: P00114
db: PANTHER Pathway Component

Segment polarity protein dishevelled homolog DVL-2
type: ProteinReference
xref: PTHR10878:SF8
xref: uniprot Q60838 698
organism: Mus musculus

P00119
type: UnificationXref
id: P00119
db: PANTHER Pathway Component

P00118
type: UnificationXref
id: P00118
db: PANTHER Pathway Component

uniprot H2RDK4 446
type: UnificationXref
id: H2RDK4
db: uniprot

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot G7ME71 333
organism: Macaca mulatta

Actin
type: ProteinReference
xref: uniprot A8JAV1 118
organism: Chlamydomonas reinhardtii

uniprot A0A2I3SWP2 890
type: UnificationXref
id: A0A2I3SWP2
db: uniprot

Glycogen synthase kinase-3 beta isoform 1
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot H9EPM1 1054
organism: Macaca mulatta

Dsh
type: Protein
entity reference: Dsh
feature: ACTIVE 517
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Neurogenic locus notch homolog protein 3
type: ProteinReference
xref: uniprot Q9UM47 458
xref: PTHR45836:SF17
organism: Homo sapiens

Protein Wnt-10a
type: ProteinReference
xref: PTHR12027:SF89
xref: uniprot Q9GZT5 875
organism: Homo sapiens

uniprot D4ACM8 363
type: UnificationXref
id: D4ACM8
db: uniprot

PARTICIPANT STOICHIOMETRY r38 1247
type: Stoichiometry
physical entity: Ire-1 C-terminal fragment
stoichiometric coefficient: 1.0

Ser beta catenin s70 sa41 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Ser
feature location: Ser beta catenin s70 sa41 rs1 Ser
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=Ser

uniprot H2QDD8 715
type: UnificationXref
id: H2QDD8
db: uniprot

PARTICIPANT STOICHIOMETRY r38 1246
type: Stoichiometry
physical entity: Ire-1 N-terminal fragment
stoichiometric coefficient: 1.0

Nectin cell adhesion molecule 1
type: ProteinReference
xref: PTHR23277:SF69
xref: uniprot F7HBK3 705
organism: Macaca mulatta

BACE-1
type: ProteinReference
xref: P00172
standard name: Beta-site amyloid precursor protein-cleaving enzyme
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.BACE-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Beta-amyloid cleavage enzyme Synonym: Asp2,memapsin-2 Accession: P00172
member entity reference: Beta-secretase 1
member entity reference: Uncharacterized protein
member entity reference: Beta-secretase 2
member entity reference: BACE2 isoform 3

P00120
type: UnificationXref
id: P00120
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r38 1245
type: Stoichiometry
physical entity: Ire-1
stoichiometric coefficient: 1.0

TRUNCATION_LEFT__Complex__Notch_N_terminal_fragment_Notch_C_terminal_fragment_-RIGHT__Notch_transmembrane_fragment-_Complex__Notch_N_terminal_fragment_Notch_extracellular_fragment_-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 1189
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 1190
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 1191
left: Complex (Notch N-terminal fragment/Notch C-terminal fragment)
interaction type: TRUNCATION
right: Notch transmembrane fragment
right: Complex (Notch N-terminal fragment/Notch extracellular fragment)

P00123
type: UnificationXref
id: P00123
db: PANTHER Pathway Component

FZD7 isoform 1
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot A0A2I3TGC6 355
organism: Pan troglodytes

P00124
type: UnificationXref
id: P00124
db: PANTHER Pathway Component

P00121
type: UnificationXref
id: P00121
db: PANTHER Pathway Component

uniprot F6TZU4 477
type: UnificationXref
id: F6TZU4
db: uniprot

uniprot Q75HX0 311
type: UnificationXref
id: Q75HX0
db: uniprot

P00122
type: UnificationXref
id: P00122
db: PANTHER Pathway Component

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot F6XMD3 786
organism: Xenopus tropicalis

Amyloid-beta A4 protein
type: ProteinReference
xref: PTHR23103:SF7
xref: uniprot P12023 41
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYD4 152
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYD3 151
organism: Branchiostoma floridae

Wnt
type: ProteinReference
xref: P00142
standard name: Wingless-type MMTV integration site family member
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Wingless-type protein Synonym: INT1L1,IRP Accession: P00142
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Wnt
member entity reference: Protein Wnt
member entity reference: Protein Wnt-6
member entity reference: Protein Wnt-11
member entity reference: Proto-oncogene Wnt-1
member entity reference: Protein Wnt-7b
member entity reference: Protein Wnt-4
member entity reference: Protein Wnt-16
member entity reference: Protein Wnt-10b
member entity reference: Protein Wnt-9a
member entity reference: Protein Wnt-8b
member entity reference: Protein Wnt-11b-1
member entity reference: Protein Wnt-2
member entity reference: Protein CBR-CWN-2
member entity reference: Protein Wnt-5a
member entity reference: Protein Wnt-10a
member entity reference: Proto-oncogene Wnt-3
member entity reference: Protein Wnt-5b
member entity reference: Protein Wnt-5
member entity reference: Protein Wnt-7a
member entity reference: Wnt homolog
member entity reference: Protein Wnt-2b
member entity reference: Protein CBR-EGL-20
member entity reference: Protein Wnt-3a

uniprot F1PYF5 584
type: UnificationXref
id: F1PYF5
db: uniprot

Cadherin-1
type: ProteinReference
xref: PTHR24027:SF319
xref: uniprot P12830 348
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF88
xref: uniprot F6SXE3 780
organism: Monodelphis domestica

uniprot F6ZSZ9 88
type: UnificationXref
id: F6ZSZ9
db: uniprot

uniprot H2Q194 803
type: UnificationXref
id: H2Q194
db: uniprot

uniprot Q90611 653
type: UnificationXref
id: Q90611
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot F0Z796 171
organism: Dictyostelium purpureum

uniprot F7E8W8 597
type: UnificationXref
id: F7E8W8
db: uniprot

uniprot Q04592 990
type: UnificationXref
id: Q04592
db: uniprot

LDL receptor related protein 4
type: ProteinReference
xref: PTHR24270:SF5
xref: uniprot A0A2I3SYK4 46
organism: Pan troglodytes

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 98

uniprot Q7SXW6 313
type: UnificationXref
id: Q7SXW6
db: uniprot

Transient receptor potential protein
type: ProteinReference
xref: uniprot P19334 495
xref: PTHR10117:SF51
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR24033:SF188
xref: uniprot A0A3Q1MTU2 438
organism: Bos taurus

P00110
type: UnificationXref
id: P00110
db: PANTHER Pathway Component

uniprot Q9NPA2 658
type: UnificationXref
id: Q9NPA2
db: uniprot

uniprot Q9I8V1 323
type: UnificationXref
id: Q9I8V1
db: uniprot

P00111
type: UnificationXref
id: P00111
db: PANTHER Pathway Component

P00112
type: UnificationXref
id: P00112
db: PANTHER Pathway Component

P00113
type: UnificationXref
id: P00113
db: PANTHER Pathway Component

uniprot H2QFL8 444
type: UnificationXref
id: H2QFL8
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot F7HEW6 798
organism: Macaca mulatta

uniprot F6XTG1 479
type: UnificationXref
id: F6XTG1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MU04 521
xref: PTHR14058:SF5
organism: Bos taurus

uniprot A0A2I3SEA5 566
type: UnificationXref
id: A0A2I3SEA5
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot Q5TP56 865
organism: Anopheles gambiae

Wnt
type: Protein
entity reference: Wnt
comment: SPECIES_TYPE=PROTEIN

uniprot Q9JMI9 505
type: UnificationXref
id: Q9JMI9
db: uniprot

Presenilin enhancer 2 homolog
type: ProteinReference
xref: uniprot H2QG41 920
xref: PTHR16318:SF0
organism: Pan troglodytes

uniprot J9P7Q4 71
type: UnificationXref
id: J9P7Q4
db: uniprot

uniprot B6V8E6 937
type: UnificationXref
id: B6V8E6
db: uniprot

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot E2QXY7 163
organism: Canis lupus familiaris

MODULATION
type: Control
xref: MODULATION
controlled: Gene transcription
controller: CD44 intracellular fragment

actin
type: Protein
entity reference: actin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__Nectin_1alpha_Afadin__alphacatenin_actin__beta_catenin_gammacatenin__E_cadherin_-RIGHT__Nectin_1alpha_C_terminal_fragment-_Nectin_1alpha_N_terminal_fragment-_r61
controller: Membrane metalloprotease

Complex (AICD/Fe65)
type: Complex
component stoichiometry: AICD s28 sa34 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fe65 s29 sa35 STOICHIOMETRY ID COMPLEX
component: Fe65
component: AICD
feature: COMPLEX BINDING FEATURE s174 a212 1151
feature: COMPLEX BINDING FEATURE s174 a212 1149
cellular location: cytosol

Protein Wnt-3a
type: ProteinReference
xref: uniprot Q2LMP1 860
xref: PTHR12027:SF88
organism: Gallus gallus

uniprot F6UA54 188
type: UnificationXref
id: F6UA54
db: uniprot

Proprotein convertase subtilisin/kexin type 2
type: ProteinReference
xref: uniprot F7G632 965
organism: Monodelphis domestica

uniprot O73864 822
type: UnificationXref
id: O73864
db: uniprot

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot Q2QL96 861
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YUR1 593
xref: PTHR10201:SF142
organism: Macaca mulatta

Presenilin-2
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot O88777 546
organism: Rattus norvegicus

uniprot F2Z4N8 181
type: UnificationXref
id: F2Z4N8
db: uniprot

PARTICIPANT STOICHIOMETRY r32 1255
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YMR3 480
xref: PTHR10117:SF9
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r32 1256
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

uniprot Q96287 1069
type: UnificationXref
id: Q96287
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Dsh-RIGHT__Dsh-_r71
controller: Complex (Wnt/Frizzled)

uniprot F7A7I3 194
type: UnificationXref
id: F7A7I3
db: uniprot

Junction plakoglobin
type: ProteinReference
xref: PTHR45976:SF3
xref: uniprot P14923 933
organism: Homo sapiens

Frizzled
type: Protein
entity reference: Frizzled
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9FVS6 1070
type: UnificationXref
id: Q9FVS6
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Gene transcription
controller: Complex (LRP intracellular fragment/Fe65)

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: PTHR24270:SF12
xref: uniprot F6PG65 55
organism: Monodelphis domestica

uniprot P57716 334
type: UnificationXref
id: P57716
db: uniprot

uniprot Q61982 453
type: UnificationXref
id: Q61982
db: uniprot

P00169
type: UnificationXref
id: P00169
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R1C6 43
xref: PTHR24270:SF22
organism: Macaca mulatta

ACTA1 isoform 1
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot H2Q1A9 205
organism: Pan troglodytes

P00177
type: UnificationXref
id: P00177
db: PANTHER Pathway Component

P00176
type: UnificationXref
id: P00176
db: PANTHER Pathway Component

uniprot F6VM33 381
type: UnificationXref
id: F6VM33
db: uniprot

Amyloid-beta A4 precursor protein-binding family B member 1
type: ProteinReference
xref: PTHR14058:SF5
xref: uniprot P46933 532
organism: Rattus norvegicus

P00179
type: UnificationXref
id: P00179
db: PANTHER Pathway Component

uniprot K7BU85 19
type: UnificationXref
id: K7BU85
db: uniprot

P00178
type: UnificationXref
id: P00178
db: PANTHER Pathway Component

P00173
type: UnificationXref
id: P00173
db: PANTHER Pathway Component

P00172
type: UnificationXref
id: P00172
db: PANTHER Pathway Component

P00175
type: UnificationXref
id: P00175
db: PANTHER Pathway Component

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot Q9WV60 1075
organism: Mus musculus

uniprot P53497 242
type: UnificationXref
id: P53497
db: uniprot

P00174
type: UnificationXref
id: P00174
db: PANTHER Pathway Component

uniprot F7A659 382
type: UnificationXref
id: F7A659
db: uniprot

Cadherin-3
type: ProteinReference
xref: uniprot P10287 347
xref: PTHR24027:SF267
organism: Mus musculus

P00171
type: UnificationXref
id: P00171
db: PANTHER Pathway Component

P00170
type: UnificationXref
id: P00170
db: PANTHER Pathway Component

uniprot D3ZB71 683
type: UnificationXref
id: D3ZB71
db: uniprot

Serine/threonine-protein kinase RIM11/MSD1
type: ProteinReference
xref: uniprot P38615 1057
organism: Saccharomyces cerevisiae

TRPC3 isoform 2
type: ProteinReference
xref: PTHR10117:SF8
xref: uniprot H2R9Y7 491
organism: Pan troglodytes

uniprot Q62849 994
type: UnificationXref
id: Q62849
db: uniprot

Collagenase 3
type: ProteinReference
evidence: Evidence 578
xref: PTHR10201:SF165
xref: uniprot F1MW26 577
organism: Bos taurus

Protein Wnt-2b
type: ProteinReference
xref: uniprot Q93097 872
xref: PTHR12027:SF93
organism: Homo sapiens

uniprot P24383 835
type: UnificationXref
id: P24383
db: uniprot

Recombining binding protein suppressor of hairless
type: ProteinReference
xref: uniprot P31266 1018
xref: PTHR10665:SF3
organism: Mus musculus

Protein Wnt-8b
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot Q93098 873
organism: Homo sapiens

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: uniprot Q9NZ42 929
xref: PTHR16318:SF0
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF150
xref: uniprot F7CIV4 196
organism: Ornithorhynchus anatinus

P00158
type: UnificationXref
id: P00158
db: PANTHER Pathway Component

Frizzled-10
type: ProteinReference
xref: uniprot Q9ULW2 432
xref: PTHR11309:SF86
organism: Homo sapiens

uniprot Q9WV60 1075
type: UnificationXref
id: Q9WV60
db: uniprot

P00159
type: UnificationXref
id: P00159
db: PANTHER Pathway Component

uniprot O35548 724
type: UnificationXref
id: O35548
db: uniprot

Amyloid beta precursor protein binding family B member 2
type: ProteinReference
xref: uniprot E2R1T9 523
organism: Canis lupus familiaris

P00164
type: UnificationXref
id: P00164
db: PANTHER Pathway Component

Presenilin N-terminal fragment
type: Protein
entity reference: Presenilin N-terminal fragment
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

P00163
type: UnificationXref
id: P00163
db: PANTHER Pathway Component

P00162
type: UnificationXref
id: P00162
db: PANTHER Pathway Component

P00168
type: UnificationXref
id: P00168
db: PANTHER Pathway Component

beta-catenin
type: Protein
entity reference: beta-catenin
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa41 1092
feature: beta catenin s70 sa41 rs2
feature: Ser beta catenin s70 sa41 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q9U6V0 882
type: UnificationXref
id: Q9U6V0
db: uniprot

P00167
type: UnificationXref
id: P00167
db: PANTHER Pathway Component

uniprot O17798 975
type: UnificationXref
id: O17798
db: uniprot

P00166
type: UnificationXref
id: P00166
db: PANTHER Pathway Component

uniprot Q61062 699
type: UnificationXref
id: Q61062
db: uniprot

P00165
type: UnificationXref
id: P00165
db: PANTHER Pathway Component

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot P18266 1056
xref: PTHR24057:SF8
organism: Rattus norvegicus

P00160
type: UnificationXref
id: P00160
db: PANTHER Pathway Component

Frizzled class receptor 10
type: ProteinReference
xref: uniprot Q6GL20 415
xref: PTHR11309:SF86
organism: Xenopus tropicalis

uniprot A0A2J8LQ46 737
type: UnificationXref
id: A0A2J8LQ46
db: uniprot

uniprot P10989 228
type: UnificationXref
id: P10989
db: uniprot

ncbitaxon 9913 12
type: UnificationXref
id: 9913
db: ncbitaxon

PTHR47965:SF69
type: RelationshipXref
id: PTHR47965:SF69
db: PANTHER Family
relationship type: By Homology

Dishevelled segment polarity protein 1
type: ProteinReference
xref: PTHR10878:SF5
xref: uniprot E2QY91 685
organism: Canis lupus familiaris

uniprot F1N5R1 774
type: UnificationXref
id: F1N5R1
db: uniprot

Tripartite motif-containing protein 2
type: ProteinReference
xref: uniprot D3ZQG6 668
organism: Rattus norvegicus

P00147
type: UnificationXref
id: P00147
db: PANTHER Pathway Component

Protein Wnt-10b
type: ProteinReference
xref: PTHR12027:SF76
xref: uniprot P48614 845
organism: Mus musculus

uniprot A3KMX5 358
type: UnificationXref
id: A3KMX5
db: uniprot

Frizzled-4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot Q9ULV1 431
organism: Homo sapiens

P00148
type: UnificationXref
id: P00148
db: PANTHER Pathway Component

Protein Wnt-11
type: ProteinReference
xref: uniprot P48615 846
xref: PTHR12027:SF7
organism: Mus musculus

uniprot P68032 263
type: UnificationXref
id: P68032
db: uniprot

uniprot G7MVY8 969
type: UnificationXref
id: G7MVY8
db: uniprot

P00149
type: UnificationXref
id: P00149
db: PANTHER Pathway Component

uniprot P41245 638
type: UnificationXref
id: P41245
db: uniprot

Gamma-secretase subunit APH-1B
type: ProteinReference
xref: PTHR12889:SF1
xref: uniprot Q8WW43 1045
organism: Homo sapiens

ncbitaxon 5664 325
type: UnificationXref
id: 5664
db: ncbitaxon

ncbitaxon 5722 103
type: UnificationXref
id: 5722
db: ncbitaxon

PTHR10201:SF115
type: RelationshipXref
id: PTHR10201:SF115
db: PANTHER Family
relationship type: By Homology

P00151
type: UnificationXref
id: P00151
db: PANTHER Pathway Component

P00150
type: UnificationXref
id: P00150
db: PANTHER Pathway Component

P00153
type: UnificationXref
id: P00153
db: PANTHER Pathway Component

Matrix metalloproteinase-16
type: ProteinReference
xref: uniprot O35548 724
organism: Rattus norvegicus

P00152
type: UnificationXref
id: P00152
db: PANTHER Pathway Component

Actin 5
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TZ58 132
organism: Physcomitrella patens

P00155
type: UnificationXref
id: P00155
db: PANTHER Pathway Component

uniprot P56705 854
type: UnificationXref
id: P56705
db: uniprot

P00154
type: UnificationXref
id: P00154
db: PANTHER Pathway Component

P00157
type: UnificationXref
id: P00157
db: PANTHER Pathway Component

Neutrophil collagenase
type: ProteinReference
xref: uniprot O88766 627
xref: PTHR10201:SF137
organism: Rattus norvegicus

P00156
type: UnificationXref
id: P00156
db: PANTHER Pathway Component

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF77
xref: uniprot C3Z2P0 752
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QBZ9 562
xref: PTHR10201:SF138
organism: Macaca mulatta

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P78711 272
organism: Neurospora crassa

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot Q6QI68 924
organism: Rattus norvegicus

uniprot E1BDE8 1007
type: UnificationXref
id: E1BDE8
db: uniprot

uniprot Q8I6Y9 502
type: UnificationXref
id: Q8I6Y9
db: uniprot

uniprot Q2LMP1 860
type: UnificationXref
id: Q2LMP1
db: uniprot

uniprot W4ZD41 330
type: UnificationXref
id: W4ZD41
db: uniprot

uniprot Q8SPJ1 936
type: UnificationXref
id: Q8SPJ1
db: uniprot

uniprot F1NYQ1 473
type: UnificationXref
id: F1NYQ1
db: uniprot

uniprot Q86BE9 926
type: UnificationXref
id: Q86BE9
db: uniprot

Low-density lipoprotein receptor-related protein 3
type: ProteinReference
xref: uniprot O75074 72
xref: PTHR24270:SF22
organism: Homo sapiens

uniprot A0A3Q3B1W2 892
type: UnificationXref
id: A0A3Q3B1W2
db: uniprot

Cadherin-1
type: ProteinReference
xref: PTHR24027:SF319
xref: uniprot Q9R0T4 350
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF477
xref: uniprot F6QWB7 182
organism: Ornithorhynchus anatinus

uniprot Q9SIK7 558
type: UnificationXref
id: Q9SIK7
db: uniprot

CD44 N-terminal fragment
type: ProteinReference
xref: P00174
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.CD44_br_N-terminal_br_fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: CD44 N-terminal fragment Synonym: Synonym not specified Accession: P00174
member entity reference: CD44 antigen
member entity reference: CD44 molecule
member entity reference: Phagocytic glycoprotein I

IDA
type: EvidenceCodeVocabulary

Putative actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A0A0D1DMT3 94
organism: Ustilago maydis

uniprot G3N2W8 388
type: UnificationXref
id: G3N2W8
db: uniprot

Furin
type: ProteinReference
xref: uniprot G7MVY8 969
xref: PTHR42884:SF1
organism: Macaca mulatta

uniprot Q9VJJ7 514
type: UnificationXref
id: Q9VJJ7
db: uniprot

Matrix metalloproteinase-9
type: ProteinReference
xref: uniprot P41245 638
xref: PTHR10201:SF30
organism: Mus musculus

Frizzled 7a
type: ProteinReference
xref: uniprot Q8QFM3 421
xref: PTHR11309:SF31
organism: Danio rerio

uniprot A0A2I3T3G9 467
type: UnificationXref
id: A0A2I3T3G9
db: uniprot

Furin
type: Protein
entity reference: Furin
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Erb-B4 intracellular fragment
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Frizzled-7
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot O75084 401
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r19 1183
type: Stoichiometry
physical entity: CD44 N-terminal fragment
stoichiometric coefficient: 1.0

uniprot P18537 403
type: UnificationXref
id: P18537
db: uniprot

PARTICIPANT STOICHIOMETRY r19 1182
type: Stoichiometry
physical entity: CD44 C-terminal fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 1181
type: Stoichiometry
physical entity: CD44
stoichiometric coefficient: 1.0

Matrix metallopeptidase 20
type: ProteinReference
xref: uniprot E2RMU9 573
xref: PTHR10201:SF125
organism: Canis lupus familiaris

uniprot F7GZ45 606
type: UnificationXref
id: F7GZ45
db: uniprot

Afadin s54 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Afadin
stoichiometric coefficient: 1.0

uniprot K7AZD4 396
type: UnificationXref
id: K7AZD4
db: uniprot

HAC1
type: Protein
entity reference: HAC1
feature: ACTIVE 517
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Actin-42A
type: ProteinReference
xref: uniprot P02572 214
xref: PTHR11937:SF453
organism: Drosophila melanogaster

ncbitaxon 5759 136
type: UnificationXref
id: 5759
db: ncbitaxon

Catenin (Cadherin-associated protein), beta 1, 88kDa
type: ProteinReference
xref: uniprot Q28GC2 948
xref: PTHR45976:SF4
organism: Xenopus tropicalis

Proto-oncogene Wnt-3
type: ProteinReference
xref: uniprot P17553 828
xref: PTHR12027:SF82
organism: Mus musculus

uniprot E1C440 36
type: UnificationXref
id: E1C440
db: uniprot

Actin, larval muscle
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P02574 216
organism: Drosophila melanogaster

eco ECO:0000250 8
type: UnificationXref
id: ECO:0000250
db: eco

uniprot P05067 39
type: UnificationXref
id: P05067
db: uniprot

TACE
type: Protein
entity reference: TACE
comment: SPECIES_TYPE=PROTEIN

Protein CBR-ACT-5
type: ProteinReference
xref: uniprot A8XS95 124
xref: PTHR11937:SF359
organism: Caenorhabditis briggsae

Transcription factor 7-like 1
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot Q6GL68 901
organism: Xenopus tropicalis

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot P21552 829
organism: Mus musculus

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: PTHR24270:SF12
xref: uniprot F1MDE1 51
organism: Bos taurus

Pen-2
type: Protein
entity reference: Pen-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa27 1116
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r24 1289
type: Stoichiometry
physical entity: LRP C-terminal fragment
stoichiometric coefficient: 1.0

uniprot P27782 900
type: UnificationXref
id: P27782
db: uniprot

uniprot Q9ESN6 678
type: UnificationXref
id: Q9ESN6
db: uniprot

uniprot H2Q5G9 66
type: UnificationXref
id: H2Q5G9
db: uniprot

uniprot E1B867 914
type: UnificationXref
id: E1B867
db: uniprot

uniprot Q8K4C8 420
type: UnificationXref
id: Q8K4C8
db: uniprot

uniprot Q6P640 305
type: UnificationXref
id: Q6P640
db: uniprot

uniprot F7GQW5 604
type: UnificationXref
id: F7GQW5
db: uniprot

Beta-actin-like protein 2
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot Q562R1 288
organism: Homo sapiens

Amyloid beta precursor protein binding family B member 2
type: ProteinReference
xref: uniprot F1MDE6 524
organism: Bos taurus

uniprot O02194 544
type: UnificationXref
id: O02194
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B1N2P0 135
organism: Entamoeba histolytica

HAC1
type: Protein
entity reference: HAC1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot A0A3Q1MDX6 357
organism: Bos taurus

Presenilin homolog
type: ProteinReference
xref: PTHR10202:SF13
xref: uniprot O02194 544
organism: Drosophila melanogaster

uniprot A7ETS6 107
type: UnificationXref
id: A7ETS6
db: uniprot

uniprot E2QXQ3 766
type: UnificationXref
id: E2QXQ3
db: uniprot

uniprot A0A1D5QEP8 437
type: UnificationXref
id: A0A1D5QEP8
db: uniprot

uniprot A0A1D5NX70 732
type: UnificationXref
id: A0A1D5NX70
db: uniprot

uniprot O75074 72
type: UnificationXref
id: O75074
db: uniprot

Matrix metalloproteinase-17
type: ProteinReference
xref: uniprot Q9R0S3 727
organism: Mus musculus

Matrix metalloproteinase-24
type: ProteinReference
xref: uniprot Q9R0S2 659
xref: PTHR10201:SF138
organism: Mus musculus

PTHR11937:SF278
type: RelationshipXref
id: PTHR11937:SF278
db: PANTHER Family
relationship type: By Homology

Nectin 1alpha N-terminal fragment
type: Protein
entity reference: Nectin 1alpha N-terminal fragment
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r24 1291
type: Stoichiometry
physical entity: LRP intracellular fragment
stoichiometric coefficient: 1.0

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 167

PARTICIPANT STOICHIOMETRY r24 1290
type: Stoichiometry
physical entity: LRP transmembrane fragment
stoichiometric coefficient: 1.0

uniprot A0A3Q1LTG6 468
type: UnificationXref
id: A0A3Q1LTG6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y0P1 1078
organism: Strongylocentrotus purpuratus

Protein Wnt
type: ProteinReference
xref: uniprot Q9I9I2 878
xref: PTHR12027:SF7
organism: Danio rerio

Matrix metalloproteinase-17
type: ProteinReference
xref: uniprot Q9ULZ9 728
organism: Homo sapiens

PTHR10201:SF7
type: RelationshipXref
id: PTHR10201:SF7
db: PANTHER Family
relationship type: By Homology

uniprot Q6UW60 996
type: UnificationXref
id: Q6UW60
db: uniprot

Anterior pharynx defective 1 homolog A
type: ProteinReference
xref: PTHR12889:SF3
xref: uniprot Q5EB22 1039
organism: Xenopus tropicalis

Afadin
type: Protein
entity reference: Afadin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Fe65
type: Protein
entity reference: Fe65
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6SH04 378
type: UnificationXref
id: F6SH04
db: uniprot

uniprot F1MHG3 771
type: UnificationXref
id: F1MHG3
db: uniprot

uniprot Q7Q3Y1 925
type: UnificationXref
id: Q7Q3Y1
db: uniprot

PTHR11937:SF248
type: RelationshipXref
id: PTHR11937:SF248
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: uniprot A0A3Q1MPF5 740
xref: PTHR12027:SF75
organism: Bos taurus

Complex (Notch N-terminal fragment/Notch extracellular fragment)
type: Complex
component stoichiometry: Notch extracellular fragment s43 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Notch N terminal fragment s42 sa3 STOICHIOMETRY ID COMPLEX
component: Notch N-terminal fragment
component: Notch extracellular fragment
feature: COMPLEX BINDING FEATURE s21 a26 1081
feature: COMPLEX BINDING FEATURE s21 a26 1079

uniprot P29122 986
type: UnificationXref
id: P29122
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot F7GH85 795
organism: Monodelphis domestica

ncbitaxon 81824 134
type: UnificationXref
id: 81824
db: ncbitaxon

uniprot A7RU31 110
type: UnificationXref
id: A7RU31
db: uniprot

uniprot F7EVX9 598
type: UnificationXref
id: F7EVX9
db: uniprot

Cadherin 1, type 1, E-cadherin (epithelial)
type: ProteinReference
xref: PTHR24027:SF319
xref: uniprot A0A0R4IFF8 340
organism: Danio rerio

PTHR11937:SF240
type: RelationshipXref
id: PTHR11937:SF240
db: PANTHER Family
relationship type: By Homology

uniprot H2Q4N0 612
type: UnificationXref
id: H2Q4N0
db: uniprot

uniprot Q9H306 656
type: UnificationXref
id: Q9H306
db: uniprot

Wnt homolog
type: ProteinReference
xref: uniprot G5EG05 802
xref: PTHR12027:SF70
organism: Caenorhabditis elegans

NICD
type: Protein
entity reference: NICD
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O35119 494
type: UnificationXref
id: O35119
db: uniprot

Glycogen synthase kinase
type: ProteinReference
xref: uniprot Q9NL43 1072
organism: Ciona intestinalis

Recombination signal-binding protein for immunoglobulin kappa J region-like
type: ProteinReference
xref: uniprot D4AEG0 1006
xref: PTHR10665:SF2
organism: Rattus norvegicus

uniprot F1P258 87
type: UnificationXref
id: F1P258
db: uniprot

uniprot F2Z4N0 179
type: UnificationXref
id: F2Z4N0
db: uniprot

uniprot A3C6D7 106
type: UnificationXref
id: A3C6D7
db: uniprot

Presenilin enhancer 2 homolog
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot Q28GF7 922
organism: Xenopus tropicalis

STATE_TRANSITION_LEFT__Dsh-RIGHT__Dsh-_r71
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1239
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1238
left: Dsh
interaction type: STATE_TRANSITION
right: Dsh

ncbitaxon 6238 121
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot Q61139 993
type: UnificationXref
id: Q61139
db: uniprot

uniprot D3ZZ42 572
type: UnificationXref
id: D3ZZ42
db: uniprot

Complex (E-cadherin/beta-catenin/ gammacatenin/alphacatenin/ actin)
type: Complex
component stoichiometry: actin s49 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: E cadherin s45 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: gammacatenin s47 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: beta catenin s46 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: alphacatenin s48 sa14 STOICHIOMETRY ID COMPLEX
component: beta-catenin
component: actin
component: alphacatenin
component: gammacatenin
component: E-cadherin
feature: COMPLEX BINDING FEATURE s94 a97 1101
feature: COMPLEX BINDING FEATURE s94 a97 1099
feature: COMPLEX BINDING FEATURE s94 a97 1095
feature: COMPLEX BINDING FEATURE s94 a97 1103
feature: COMPLEX BINDING FEATURE s94 a97 1097
cellular location: cytosol

Catenin beta-1
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot F1QGH7 939
organism: Danio rerio

uniprot Q8CGU6 336
type: UnificationXref
id: Q8CGU6
db: uniprot

uniprot Q99MK2 723
type: UnificationXref
id: Q99MK2
db: uniprot

uniprot P07828 217
type: UnificationXref
id: P07828
db: uniprot

Frizzled-9
type: ProteinReference
xref: PTHR11309:SF79
xref: uniprot O00144 397
organism: Homo sapiens

uniprot H2Q4N3 613
type: UnificationXref
id: H2Q4N3
db: uniprot

uniprot H2Q1A9 205
type: UnificationXref
id: H2Q1A9
db: uniprot

uniprot F6RFW8 184
type: UnificationXref
id: F6RFW8
db: uniprot

uniprot C3XYC3 145
type: UnificationXref
id: C3XYC3
db: uniprot

Dsh
type: Protein
entity reference: Dsh
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein Wnt
type: ProteinReference
xref: uniprot H2Q194 803
xref: PTHR12027:SF75
organism: Pan troglodytes

uniprot B0JYR0 953
type: UnificationXref
id: B0JYR0
db: uniprot

PARTICIPANT STOICHIOMETRY re56 1187
type: Stoichiometry
physical entity: Capacitative calcium channels
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re56 1188
type: Stoichiometry
physical entity: Capacitative calcium channels
stoichiometric coefficient: 1.0

uniprot Q91VN0 81
type: UnificationXref
id: Q91VN0
db: uniprot

uniprot C3XYC7 149
type: UnificationXref
id: C3XYC7
db: uniprot

Neurogenic locus notch homolog protein 3
type: ProteinReference
xref: uniprot Q9R172 457
xref: PTHR45836:SF17
organism: Rattus norvegicus

uniprot A8WS33 122
type: UnificationXref
id: A8WS33
db: uniprot

PCSK2 isoform 2
type: ProteinReference
xref: uniprot H2QJZ8 971
organism: Pan troglodytes

uniprot P60712 249
type: UnificationXref
id: P60712
db: uniprot

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot Q9VC27 339
organism: Drosophila melanogaster

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: uniprot H2Q5G9 66
xref: PTHR24270:SF12
organism: Pan troglodytes

uniprot F1MM00 11
type: UnificationXref
id: F1MM00
db: uniprot

Membrane metalloprotease
type: Protein
entity reference: Membrane metalloprotease
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9PWH2 428
type: UnificationXref
id: Q9PWH2
db: uniprot

Transient receptor potential cation channel subfamily C member 3
type: ProteinReference
xref: PTHR10117:SF8
xref: uniprot A0A3Q1M4W2 469
organism: Bos taurus

uniprot F1PVZ8 474
type: UnificationXref
id: F1PVZ8
db: uniprot

CD44 N-terminal fragment
type: Protein
entity reference: CD44 N-terminal fragment
comment: SPECIES_TYPE=PROTEIN

CD44
type: Protein
entity reference: CD44
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein Wnt-5a
type: ProteinReference
xref: uniprot P41221 842
xref: PTHR12027:SF33
organism: Homo sapiens

Frizzled class receptor 6
type: ProteinReference
xref: uniprot H2R2C6 394
xref: PTHR11309:SF75
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r52 1298
type: Stoichiometry
physical entity: Complex (AICD/Fe65)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r52 1299
type: Stoichiometry
physical entity: Tip60
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XN03 478
xref: PTHR10117:SF7
organism: Monodelphis domestica

Macrophage metalloelastase
type: ProteinReference
xref: PTHR10201:SF267
xref: uniprot Q63341 650
organism: Rattus norvegicus

uniprot G3V7U3 800
type: UnificationXref
id: G3V7U3
db: uniprot

PARTICIPANT STOICHIOMETRY r77 1210
type: Stoichiometry
physical entity: Erb-B4 intracellular fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r77 1211
type: Stoichiometry
physical entity: Erb-B4 intracellular fragment
stoichiometric coefficient: 1.0

uniprot F1QBI2 372
type: UnificationXref
id: F1QBI2
db: uniprot

uniprot J9P2Q5 813
type: UnificationXref
id: J9P2Q5
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Low-density lipoprotein receptor-related protein 2
type: ProteinReference
xref: PTHR22722:SF5
xref: uniprot P98164 78
organism: Homo sapiens

uniprot Q93098 873
type: UnificationXref
id: Q93098
db: uniprot

ncbitaxon 559292 26
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot H2QJA9 392
type: UnificationXref
id: H2QJA9
db: uniprot

uniprot Q9VQG2 1047
type: UnificationXref
id: Q9VQG2
db: uniprot

uniprot F7EC93 486
type: UnificationXref
id: F7EC93
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot F1MJS2 893
organism: Bos taurus

Notch C-terminal fragment
type: Protein
entity reference: Notch C-terminal fragment
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 232

Actin, muscle
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot W4XTP5 328
organism: Strongylocentrotus purpuratus

uniprot P51512 644
type: UnificationXref
id: P51512
db: uniprot

uniprot F6WYF2 591
type: UnificationXref
id: F6WYF2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24027:SF267
xref: uniprot F7D992 344
organism: Macaca mulatta

Presenilin C-terminal fragment
type: Protein
entity reference: Presenilin C-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa29 1120
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF362
xref: uniprot Q7ZVI7 316
organism: Danio rerio

Protein Wnt-4
type: ProteinReference
xref: PTHR12027:SF101
xref: uniprot P56705 854
organism: Homo sapiens

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TYG6 131
organism: Physcomitrella patens

Protein Wnt-7b
type: ProteinReference
xref: PTHR12027:SF73
xref: uniprot P56706 855
organism: Homo sapiens

Presenilin hop-1
type: ProteinReference
xref: PTHR10202:SF14
xref: uniprot O02100 543
organism: Caenorhabditis elegans

uniprot P68034 265
type: UnificationXref
id: P68034
db: uniprot

uniprot F7GG37 603
type: UnificationXref
id: F7GG37
db: uniprot

uniprot A4ZGP0 742
type: UnificationXref
id: A4ZGP0
db: uniprot

uniprot P49768 547
type: UnificationXref
id: P49768
db: uniprot

Proto-oncogene Wnt-3
type: ProteinReference
xref: PTHR12027:SF82
xref: uniprot P56703 852
organism: Homo sapiens

Protein Wnt-3a
type: ProteinReference
xref: PTHR12027:SF88
xref: uniprot P56704 853
organism: Homo sapiens

Predicted protein
type: ProteinReference
xref: uniprot A9TYG3 130
xref: PTHR11937:SF387
organism: Physcomitrella patens

uniprot C3XYC2 143
type: UnificationXref
id: C3XYC2
db: uniprot

beta-catenin
type: Protein
entity reference: beta-catenin
feature: beta catenin s131 a164 rs2
feature: Ser beta catenin s131 a164 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q9XT96 560
type: UnificationXref
id: Q9XT96
db: uniprot

uniprot Q9Y5R2 661
type: UnificationXref
id: Q9Y5R2
db: uniprot

LRP transmembrane fragment
type: Protein
entity reference: LRP transmembrane fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7E738 792
type: UnificationXref
id: F7E738
db: uniprot

AICD
type: ProteinReference
xref: P00166
standard name: Amyloid precursor protein intracellular domain
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.AICD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta A4 protein
member entity reference: Amyloid-beta precursor protein

uniprot P29121 985
type: UnificationXref
id: P29121
db: uniprot

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot P09544 826
organism: Homo sapiens

Ser beta catenin s87 a103 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Ser
feature location: Ser beta catenin s87 a103 rs1 Ser
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=Ser

Protein Wnt-7a
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot P24383 835
organism: Mus musculus

uniprot Q5R1X3 296
type: UnificationXref
id: Q5R1X3
db: uniprot

uniprot P84185 275
type: UnificationXref
id: P84185
db: uniprot

E-cadherin C-terminal fragment
type: ProteinReference
xref: P00117
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.E-cadherin_br_C-terminal_br_fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: E-cadherin C-terminal fragment Synonym: Synonym not specified Accession: P00117
member entity reference: Cadherin-1
member entity reference: Cadherin-3
member entity reference: Cadherin 3
member entity reference: Uncharacterized protein
member entity reference: CDH1 isoform 1
member entity reference: Cadherin 1, type 1, E-cadherin (epithelial)
member entity reference: CDH3 isoform 2

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HG05 911
xref: PTHR10398:SF2
organism: Macaca mulatta

Actin A
type: ProteinReference
xref: uniprot Q38E94 282
organism: Trypanosoma brucei

Protein Wnt
type: ProteinReference
xref: uniprot F6TCQ4 781
xref: PTHR12027:SF82
organism: Xenopus tropicalis

uniprot P24257 834
type: UnificationXref
id: P24257
db: uniprot

Erb-B4
type: ProteinReference
xref: P00128
standard name: V-erb-a erythroblastic leukemia viral oncogene homolog 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: V-erb-a erythroblastic leukemia viral oncogene homolog 4 Synonym: HER4 Accession: P00128
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Erb-B4
member entity reference: Receptor protein-tyrosine kinase
member entity reference: Receptor tyrosine-protein kinase erbB-4

Frizzled
type: Protein
entity reference: Frizzled
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa44 1176
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Catenin beta 1
type: ProteinReference
xref: uniprot F6WBD5 941
xref: PTHR45976:SF4
organism: Ornithorhynchus anatinus

uniprot Q12841 857
type: UnificationXref
id: Q12841
db: uniprot

PTHR24026:SF108
type: RelationshipXref
id: PTHR24026:SF108
db: PANTHER Family
relationship type: By Homology

Transcription factor 7-like 2
type: ProteinReference
xref: uniprot Q9NQB0 904
xref: PTHR10373:SF32
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__CD44_C_terminal_fragment-RIGHT__CD44_transmembrane_fragment-_CD44_intracellular_fragment-_r20
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

Frizzled-9
type: ProteinReference
xref: PTHR11309:SF79
xref: uniprot Q8K4C8 420
organism: Rattus norvegicus

uniprot P51030 851
type: UnificationXref
id: P51030
db: uniprot

Furin
type: ProteinReference
xref: uniprot P09958 976
xref: PTHR42884:SF1
organism: Homo sapiens

ACTC1 isoform 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot H2Q943 206
organism: Pan troglodytes

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 26

Transient receptor potential cation channel subfamily C member 6
type: ProteinReference
xref: uniprot F7B2E9 481
xref: PTHR10117:SF7
organism: Ornithorhynchus anatinus

uniprot F1MEW8 770
type: UnificationXref
id: F1MEW8
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 215

ncbitaxon 321614 204
type: UnificationXref
id: 321614
db: ncbitaxon

uniprot H2Q4M0 488
type: UnificationXref
id: H2Q4M0
db: uniprot

uniprot Q56A35 289
type: UnificationXref
id: Q56A35
db: uniprot

uniprot J9P0J9 921
type: UnificationXref
id: J9P0J9
db: uniprot

Proprotein convertase subtilisin/kexin type 4
type: ProteinReference
xref: uniprot Q78EH2 997
organism: Rattus norvegicus

uniprot A8Y4R0 126
type: UnificationXref
id: A8Y4R0
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot H2QD96 807
xref: PTHR12027:SF82
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10665:SF3
xref: uniprot A0A3Q2UCS9 1004
organism: Gallus gallus

uniprot Q9QZH0 429
type: UnificationXref
id: Q9QZH0
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q9UVF3 326
organism: Yarrowia lipolytica

AICD s30 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

uniprot Q6NVA9 303
type: UnificationXref
id: Q6NVA9
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Notch_transmembrane_fragment-RIGHT__Notch_fragment-_NICD-_r4
controller: Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)

Transient receptor potential cation channel, subfamily C, member 5
type: ProteinReference
xref: PTHR10117:SF76
xref: uniprot A0A0G2K149 464
organism: Rattus norvegicus

uniprot Q8CHK4 721
type: UnificationXref
id: Q8CHK4
db: uniprot

Capacitative calcium channels
type: Protein
entity reference: Capacitative calcium channels
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Y210 516
type: UnificationXref
id: Q9Y210
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot G3V7U3 800
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EU36 199
xref: PTHR11937:SF414
organism: Monodelphis domestica

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa31 1172
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot J9P315 70
type: UnificationXref
id: J9P315
db: uniprot

uniprot P50281 641
type: UnificationXref
id: P50281
db: uniprot

uniprot Q9LIS6 1071
type: UnificationXref
id: Q9LIS6
db: uniprot

Rbpja protein
type: ProteinReference
xref: uniprot A4FTT3 1005
xref: PTHR10665:SF3
organism: Danio rerio

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot F6XGB0 785
organism: Ornithorhynchus anatinus

ncbitaxon 185431 283
type: UnificationXref
id: 185431
db: ncbitaxon

uniprot Q02248 946
type: UnificationXref
id: Q02248
db: uniprot

Fe65 s31 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

uniprot P68138 270
type: UnificationXref
id: P68138
db: uniprot

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 319

uniprot P63268 260
type: UnificationXref
id: P63268
db: uniprot

Frizzled-4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot Q9IA05 425
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot W4ZD41 330
xref: PTHR11937:SF446
organism: Strongylocentrotus purpuratus

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: uniprot F7ACT4 1053
xref: PTHR24057:SF8
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2TVV5 1049
xref: PTHR24057:SF8
organism: Gallus gallus

Cytoplasmatic actin
type: ProteinReference
xref: PTHR11937:SF423
xref: uniprot E9HGF5 170
organism: Daphnia pulex

PTHR24270:SF5
type: RelationshipXref
id: PTHR24270:SF5
db: PANTHER Family
relationship type: By Homology

CSL
type: Protein
entity reference: CSL
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa5 1084
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P43289 1059
type: UnificationXref
id: P43289
db: uniprot

uniprot F7DHZ3 714
type: UnificationXref
id: F7DHZ3
db: uniprot

Actin alpha 1, skeletal muscle a
type: ProteinReference
xref: PTHR11937:SF416
xref: uniprot F1QUN8 176
organism: Danio rerio

uniprot P47793 844
type: UnificationXref
id: P47793
db: uniprot

STATE_TRANSITION_LEFT__HAC1-RIGHT__HAC1-_r39
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 1244
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 1243
left: HAC1
interaction type: STATE_TRANSITION
right: HAC1

uniprot Q0IPW3 279
type: UnificationXref
id: Q0IPW3
db: uniprot

uniprot F6WBI3 15
type: UnificationXref
id: F6WBI3
db: uniprot

uniprot D3ZRN3 162
type: UnificationXref
id: D3ZRN3
db: uniprot

PTHR10201:SF29
type: RelationshipXref
id: PTHR10201:SF29
db: PANTHER Family
relationship type: By Homology

PTHR14058:SF5
type: RelationshipXref
id: PTHR14058:SF5
db: PANTHER Family
relationship type: By Homology

Protein Wnt-8a
type: ProteinReference
xref: uniprot Q9H1J5 876
xref: PTHR12027:SF92
organism: Homo sapiens

Protein Wnt-5b
type: ProteinReference
xref: PTHR12027:SF87
xref: uniprot Q9H1J7 877
organism: Homo sapiens

uniprot H2QK91 617
type: UnificationXref
id: H2QK91
db: uniprot

Putative gamma-secretase subunit APH-1C
type: ProteinReference
xref: PTHR12889:SF1
xref: uniprot Q9DCZ9 1046
organism: Mus musculus

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot Q5R1X3 296
xref: PTHR11937:SF192
organism: Pan troglodytes

Short transient receptor potential channel 1
type: ProteinReference
xref: uniprot Q9QX01 507
xref: PTHR10117:SF56
organism: Rattus norvegicus

uniprot F7H7P6 796
type: UnificationXref
id: F7H7P6
db: uniprot

PTHR10201:SF24
type: RelationshipXref
id: PTHR10201:SF24
db: PANTHER Family
relationship type: By Homology

Membrane metalloprotease
type: ProteinReference
xref: P00141
comment: ENTITY_REFERENCE_NOTES=Long Name: Membrane metalloprotease Synonym: Synonym not specified Accession: P00141
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Membrane_br_metalloprotease
member entity reference: Matrix metalloproteinase-24
member entity reference: Matrix metallopeptidase 15
member entity reference: Matrix metalloproteinase-15
member entity reference: Matrix metalloproteinase-25
member entity reference: Uncharacterized protein
member entity reference: Matrix metalloproteinase-14
member entity reference: Matrix metalloproteinase-16
member entity reference: MMP15 isoform 1
member entity reference: Matrix metalloproteinase-17
member entity reference: Matrix metalloproteinase-14 preproprotein
member entity reference: MMP14 isoform 1

PTHR10201:SF25
type: RelationshipXref
id: PTHR10201:SF25
db: PANTHER Family
relationship type: By Homology

PTHR10201:SF26
type: RelationshipXref
id: PTHR10201:SF26
db: PANTHER Family
relationship type: By Homology

Pro-BACE-1
type: ProteinReference
xref: P00162
standard name: Pro-beta-secretase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Pro-BACE-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Pro-BACE-1 Synonym: Synonym not specified Accession: P00162
member entity reference: Beta-secretase 1
member entity reference: Uncharacterized protein
member entity reference: Beta-secretase 2
member entity reference: BACE2 isoform 3

beta-catenin
type: Protein
entity reference: beta-catenin
feature: Ser beta catenin s121 a152 rs1
feature: beta catenin s121 a152 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ire-1 C-terminal fragment
type: Protein
entity reference: Ire-1 C-terminal fragment
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

FZD9 isoform 1
type: ProteinReference
xref: PTHR11309:SF79
xref: uniprot H2R591 395
organism: Pan troglodytes

uniprot Q9YHE8 908
type: UnificationXref
id: Q9YHE8
db: uniprot

uniprot A0A3Q1MPF5 740
type: UnificationXref
id: A0A3Q1MPF5
db: uniprot

Frizzled-4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot A0A1D5Q1B1 354
organism: Macaca mulatta

PTHR10201:SF30
type: RelationshipXref
id: PTHR10201:SF30
db: PANTHER Family
relationship type: By Homology

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 234

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot F6UA54 188
organism: Macaca mulatta

uniprot P45891 235
type: UnificationXref
id: P45891
db: uniprot

PTHR11937:SF37
type: RelationshipXref
id: PTHR11937:SF37
db: PANTHER Family
relationship type: By Homology

Presenilin spe-4
type: ProteinReference
xref: uniprot Q01608 552
xref: PTHR10202:SF25
organism: Caenorhabditis elegans

uniprot F6YF14 537
type: UnificationXref
id: F6YF14
db: uniprot

uniprot Q8N119 652
type: UnificationXref
id: Q8N119
db: uniprot

Matrix metalloprotease
type: Protein
entity reference: Matrix metalloprotease
comment: SPECIES_TYPE=PROTEIN

Frizzled class receptor 2
type: ProteinReference
xref: uniprot H2QD74 391
xref: PTHR11309:SF34
organism: Pan troglodytes

TCF LEF s74 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCF/LEF
stoichiometric coefficient: 1.0

PTHR46513:SF16
type: RelationshipXref
id: PTHR46513:SF16
db: PANTHER Family
relationship type: By Homology

GO GO:0005783 3
type: UnificationXref
id: GO:0005783
db: GO

uniprot A9V489 133
type: UnificationXref
id: A9V489
db: uniprot

TRIGGER
type: RelationshipTypeVocabulary

TRANSPORT_LEFT__Complex__AICD_Fe65_-RIGHT__Complex__AICD_Fe65_-_r76
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 1222
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 1221
left: Complex (AICD/Fe65)
interaction type: TRANSPORT
right: Complex (AICD/Fe65)

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF84
xref: uniprot D3ZFS0 756
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__TCF_LEF-_beta_catenin-RIGHT__Complex__beta_catenin_TCF__LEF_-_r67
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 1252
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 1250
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 1251
left: beta-catenin
left: TCF/LEF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (beta-catenin/TCF/ LEF)

Proprotein convertase subtilisin/kexin type 4
type: ProteinReference
xref: uniprot Q6UW60 996
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_r31
controller: GSK-3beta

uniprot H2R2C6 394
type: UnificationXref
id: H2R2C6
db: uniprot

ncbitaxon 6239 213
type: UnificationXref
id: 6239
db: ncbitaxon

Amyloid-beta A4 precursor protein-binding family B member 3
type: ProteinReference
xref: uniprot O35827 530
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r63 1266
type: Stoichiometry
physical entity: Nectin 1alpha C-terminal fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 1267
type: Stoichiometry
physical entity: Nectin 1alpha intracellular fragment
stoichiometric coefficient: 1.0

Transient receptor potential cation channel subfamily C member 4
type: ProteinReference
xref: PTHR10117:SF25
xref: uniprot F1Q223 475
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r42 1237
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 1268
type: Stoichiometry
physical entity: Nectin 1alpha transmembrane fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r42 1236
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__CD44-RIGHT__CD44_C_terminal_fragment-_CD44_N_terminal_fragment-_r19
controller: Membrane metalloprotease

uniprot H2KNE6 203
type: UnificationXref
id: H2KNE6
db: uniprot

Matrix metalloproteinase-9
type: ProteinReference
xref: uniprot F6W5A7 589
xref: PTHR10201:SF30
organism: Macaca mulatta

uniprot F6PGQ1 1052
type: UnificationXref
id: F6PGQ1
db: uniprot

Actin-related protein 2
type: ProteinReference
xref: PTHR11937:SF37
xref: uniprot Q5M7U6 294
organism: Rattus norvegicus

uniprot Q63341 650
type: UnificationXref
id: Q63341
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_BACE_1-RIGHT__BACE_1-_BACE_1_pro_domain-_r43
controller: Furin

uniprot Q15303 91
type: UnificationXref
id: Q15303
db: uniprot

Matrix metallopeptidase 15
type: ProteinReference
xref: PTHR10201:SF25
xref: uniprot D3ZCG5 570
organism: Rattus norvegicus

Transient receptor potential cation channel subfamily C member 7
type: ProteinReference
xref: uniprot F7CZL9 483
xref: PTHR10117:SF9
organism: Monodelphis domestica

Short transient receptor potential channel 1
type: ProteinReference
xref: PTHR10117:SF56
xref: uniprot Q61056 499
organism: Mus musculus

uniprot F6QWB7 182
type: UnificationXref
id: F6QWB7
db: uniprot

GO GO:0005794 4
type: UnificationXref
id: GO:0005794
db: GO

Notch N-terminal fragment
type: ProteinReference
xref: P00171
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: Notch N-terminal fragment Synonym: Synonym not specified Accession: P00171
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Notch_br_N-terminal_br_fragment
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Notch 4
member entity reference: Notch 3
member entity reference: Neurogenic locus Notch protein
member entity reference: Notch 1
member entity reference: NOTCH3 isoform 1
member entity reference: NOTCH1 isoform 1

Protein Wnt-9a
type: ProteinReference
xref: uniprot Q8R5M2 869
xref: PTHR12027:SF75
organism: Mus musculus

uniprot Q9UBN4 512
type: UnificationXref
id: Q9UBN4
db: uniprot

uniprot Q61091 414
type: UnificationXref
id: Q61091
db: uniprot

Protein Wnt-8b
type: ProteinReference
xref: uniprot Q9WUD6 884
xref: PTHR12027:SF94
organism: Mus musculus

Protein Wnt-4
type: ProteinReference
xref: PTHR12027:SF111
xref: uniprot P40589 841
organism: Drosophila melanogaster

Histone acetyltransferase
type: ProteinReference
xref: uniprot K7BDV3 716
xref: PTHR10615:SF183
organism: Pan troglodytes

uniprot D4ADV8 684
type: UnificationXref
id: D4ADV8
db: uniprot

Aph 1 s15 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Aph-1
stoichiometric coefficient: 1.0

uniprot Q04721 451
type: UnificationXref
id: Q04721
db: uniprot

uniprot Q01608 552
type: UnificationXref
id: Q01608
db: uniprot

uniprot E2RB53 1051
type: UnificationXref
id: E2RB53
db: uniprot

Matrix metallopeptidase 15
type: ProteinReference
xref: uniprot F1P625 581
xref: PTHR10201:SF25
organism: Canis lupus familiaris

uniprot F6YB95 1010
type: UnificationXref
id: F6YB95
db: uniprot

uniprot P09958 976
type: UnificationXref
id: P09958
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F7D4J8 790
xref: PTHR12027:SF94
organism: Monodelphis domestica

uniprot O95251 717
type: UnificationXref
id: O95251
db: uniprot

Segment polarity protein dishevelled homolog DVL-3
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot Q61062 699
organism: Mus musculus

RING finger protein 22
type: ProteinReference
xref: uniprot A0A1D5RG25 663
organism: Macaca mulatta

uniprot E9HGF5 170
type: UnificationXref
id: E9HGF5
db: uniprot

uniprot P60706 245
type: UnificationXref
id: P60706
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF362
xref: uniprot Q7ZVF9 315
organism: Danio rerio

uniprot Q08463 404
type: UnificationXref
id: Q08463
db: uniprot

uniprot P62737 253
type: UnificationXref
id: P62737
db: uniprot

uniprot P57748 647
type: UnificationXref
id: P57748
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UA63 189
xref: PTHR11937:SF201
organism: Macaca mulatta

uniprot Q9QYS1 881
type: UnificationXref
id: Q9QYS1
db: uniprot

Protein Wnt-4a
type: ProteinReference
xref: PTHR12027:SF105
xref: uniprot P47793 844
organism: Danio rerio

uniprot G3V819 801
type: UnificationXref
id: G3V819
db: uniprot

Short transient receptor potential channel 7
type: ProteinReference
xref: PTHR10117:SF9
xref: uniprot Q9HCX4 504
organism: Homo sapiens

Complex (Nectin 1alpha/Afadin)
type: Complex
component stoichiometry: Afadin s12 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Nectin 1alpha s11 sa16 STOICHIOMETRY ID COMPLEX
component: Afadin
component: Nectin 1alpha
feature: COMPLEX BINDING FEATURE s102 a110 1147
feature: COMPLEX BINDING FEATURE s102 a110 1145
cellular location: cytosol

alphacatenin s57 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alphacatenin
stoichiometric coefficient: 1.0

uniprot H2Q2R2 608
type: UnificationXref
id: H2Q2R2
db: uniprot

uniprot F6XJP7 963
type: UnificationXref
id: F6XJP7
db: uniprot

PARTICIPANT STOICHIOMETRY r16 1194
type: Stoichiometry
physical entity: Erb-B4 intracellular fragment
stoichiometric coefficient: 1.0

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: uniprot F2Z4N0 179
xref: PTHR11937:SF201
organism: Canis lupus familiaris

uniprot F6SF10 778
type: UnificationXref
id: F6SF10
db: uniprot

Dishevelled segment polarity protein 3
type: ProteinReference
xref: uniprot F1MMW6 687
xref: PTHR10878:SF6
organism: Bos taurus

Ire-1 N-terminal fragment
type: Protein
entity reference: Ire-1 N-terminal fragment
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Ire_1-RIGHT__Ire_1_N_terminal_fragment-_Ire_1_C_terminal_fragment-_r38
controller: Presenilin

uniprot P60709 246
type: UnificationXref
id: P60709
db: uniprot

Low-density lipoprotein receptor-related protein 6
type: ProteinReference
xref: PTHR24270:SF12
xref: uniprot O88572 77
organism: Mus musculus

Actin, gamma 2, smooth muscle, enteric
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot F2Z4N8 181
organism: Canis lupus familiaris

Matrix metalloproteinase-14
type: ProteinReference
xref: PTHR10201:SF24
xref: uniprot Q9GLE4 655
organism: Bos taurus

Actin, alpha, cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot F2Z4N7 180
organism: Canis lupus familiaris

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

uniprot Q6P0K8 935
type: UnificationXref
id: Q6P0K8
db: uniprot

C99
type: Protein
entity reference: C99
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa32 1088
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF72
xref: uniprot J9NZJ2 812
organism: Canis lupus familiaris

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF7
xref: uniprot G3V819 801
organism: Rattus norvegicus

Matrix metalloproteinase-16
type: ProteinReference
xref: PTHR10201:SF26
xref: uniprot P51512 644
organism: Homo sapiens

uniprot F7AGU8 539
type: UnificationXref
id: F7AGU8
db: uniprot

Matrix metalloproteinase-15
type: ProteinReference
xref: PTHR10201:SF25
xref: uniprot P51511 643
organism: Homo sapiens

uniprot P28047 837
type: UnificationXref
id: P28047
db: uniprot

Nicastrin
type: ProteinReference
xref: PTHR21092:SF0
xref: uniprot F1PU73 332
organism: Canis lupus familiaris

Bos taurus
type: BioSource
xref: ncbitaxon 9913 12

Actin alpha cardiac muscle 1b
type: ProteinReference
xref: PTHR11937:SF184
xref: uniprot Q9I8V1 323
organism: Danio rerio

uniprot P27467 836
type: UnificationXref
id: P27467
db: uniprot

Matrix metallopeptidase 24
type: ProteinReference
xref: uniprot F1Q270 585
xref: PTHR10201:SF138
organism: Canis lupus familiaris

Proprotein convertase subtilisin/kexin type 5
type: ProteinReference
xref: uniprot Q04592 990
organism: Mus musculus

uniprot F6SV99 379
type: UnificationXref
id: F6SV99
db: uniprot

Evidence 564
type: Evidence
evidence code: ISS
comment: free text Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.

Notch N-terminal fragment
type: Protein
entity reference: Notch N-terminal fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot H3F5B4 208
xref: PTHR11937:SF359
organism: Pristionchus pacificus

HETERODIMER_ASSOCIATION_LEFT__Wnt-_Frizzled-RIGHT__Complex__Wnt_Frizzled_-_r70
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 1242
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 1240
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 1241
left: Wnt
left: Frizzled
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Wnt/Frizzled)

uniprot Q93VJ2 29
type: UnificationXref
id: Q93VJ2
db: uniprot

Presenilin
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot H2Q8K1 541
organism: Pan troglodytes

uniprot E2RAF3 366
type: UnificationXref
id: E2RAF3
db: uniprot

Frizzled class receptor 8
type: ProteinReference
xref: uniprot F7CDC6 383
xref: PTHR11309:SF90
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r16 1193
type: Stoichiometry
physical entity: Erb-B4 transmembrane fragment
stoichiometric coefficient: 1.0

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot F1MCT1 958
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r16 1192
type: Stoichiometry
physical entity: Erb-B4 C-terminal fragment
stoichiometric coefficient: 1.0

uniprot Q61088 411
type: UnificationXref
id: Q61088
db: uniprot

uniprot Q92997 700
type: UnificationXref
id: Q92997
db: uniprot

uniprot P08592 40
type: UnificationXref
id: P08592
db: uniprot

uniprot P21661 978
type: UnificationXref
id: P21661
db: uniprot

uniprot Q8I4X0 318
type: UnificationXref
id: Q8I4X0
db: uniprot

BACE-1
type: Protein
entity reference: BACE-1
feature: ACTIVE 517
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O74954 1016
type: UnificationXref
id: O74954
db: uniprot

uniprot F6U002 962
type: UnificationXref
id: F6U002
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q7YTV5 314
organism: Trichoplax adhaerens

PTHR10201:SF267
type: RelationshipXref
id: PTHR10201:SF267
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase/endoribonuclease IRE1a
type: ProteinReference
xref: PTHR13954:SF6
xref: uniprot Q9C5S2 31
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r37 1249
type: Stoichiometry
physical entity: Ire-1
stoichiometric coefficient: 1.0

uniprot Q23316 335
type: UnificationXref
id: Q23316
db: uniprot

uniprot J9P5H0 814
type: UnificationXref
id: J9P5H0
db: uniprot

uniprot F1MMW6 687
type: UnificationXref
id: F1MMW6
db: uniprot

uniprot P33434 634
type: UnificationXref
id: P33434
db: uniprot

PARTICIPANT STOICHIOMETRY r37 1248
type: Stoichiometry
physical entity: Ire-1
stoichiometric coefficient: 1.0

MODULATION
type: Control
xref: MODULATION
controlled: Gene transcription
controller: Complex (AICD/Fe65/ Tip60)

FZD10 protein
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot A3KMX5 358
organism: Bos taurus

Low-density lipoprotein receptor-related protein 2
type: ProteinReference
xref: PTHR22722:SF5
xref: uniprot A2ARV4 47
organism: Mus musculus

uniprot D4A9J2 762
type: UnificationXref
id: D4A9J2
db: uniprot

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: PTHR10878:SF5
xref: uniprot P51141 696
organism: Mus musculus

uniprot A0A3Q1MBH7 1032
type: UnificationXref
id: A0A3Q1MBH7
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 142

Evidence 578
type: Evidence
evidence code: TAS
comment: free text Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.

uniprot Q6DMS2 501
type: UnificationXref
id: Q6DMS2
db: uniprot

PANTHER Pathway P00004 1
type: UnificationXref
id: P00004
db: PANTHER Pathway

uniprot Q9UP38 433
type: UnificationXref
id: Q9UP38
db: uniprot

Nectin cell adhesion molecule 1
type: ProteinReference
xref: PTHR23277:SF69
xref: uniprot F1LNP8 702
organism: Rattus norvegicus

uniprot O02100 543
type: UnificationXref
id: O02100
db: uniprot

Glycogen synthase kinase-3
type: ProteinReference
xref: uniprot P51136 1061
organism: Dictyostelium discoideum

Endoplasmic reticulum (ER) to nucleus signalling 2 (Predicted)
type: ProteinReference
xref: uniprot D3ZTI7 10
xref: PTHR13954:SF15
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: uniprot F1MEW8 770
xref: PTHR12027:SF89
organism: Bos taurus

Tripartite motif containing 3
type: ProteinReference
xref: uniprot A0A2I3T7E0 664
organism: Pan troglodytes

uniprot Q61056 499
type: UnificationXref
id: Q61056
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF72
xref: uniprot F1MN70 772
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SRK5 940
xref: PTHR45976:SF4
organism: Monodelphis domestica

uniprot F1MDE6 524
type: UnificationXref
id: F1MDE6
db: uniprot

uniprot O94537 23
type: UnificationXref
id: O94537
db: uniprot

uniprot C3ZMR2 160
type: UnificationXref
id: C3ZMR2
db: uniprot

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: PTHR10878:SF5
xref: uniprot Q5IS48 697
organism: Pan troglodytes

LDL receptor related protein 1
type: ProteinReference
xref: PTHR24270:SF23
xref: uniprot E1BGJ0 48
organism: Bos taurus

uniprot H2QI87 899
type: UnificationXref
id: H2QI87
db: uniprot

uniprot H2QG00 67
type: UnificationXref
id: H2QG00
db: uniprot

uniprot E2RDT2 767
type: UnificationXref
id: E2RDT2
db: uniprot

uniprot O77438 402
type: UnificationXref
id: O77438
db: uniprot

Putative actin-22
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot Q553U6 286
organism: Dictyostelium discoideum

uniprot W4Y969 329
type: UnificationXref
id: W4Y969
db: uniprot

uniprot F1P7G9 13
type: UnificationXref
id: F1P7G9
db: uniprot

Ser beta catenin s122 a153 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Ser
feature location: Ser beta catenin s122 a153 rs1 Ser
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=Ser

uniprot F6XP71 592
type: UnificationXref
id: F6XP71
db: uniprot

uniprot Q5IS48 697
type: UnificationXref
id: Q5IS48
db: uniprot

Actin, gamma
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P20359 231
organism: Emericella nidulans

LDL receptor related protein 3
type: ProteinReference
xref: PTHR24270:SF22
xref: uniprot G3MX13 63
organism: Bos taurus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 37

uniprot Q9QX01 507
type: UnificationXref
id: Q9QX01
db: uniprot

uniprot Q8JHF0 927
type: UnificationXref
id: Q8JHF0
db: uniprot

Matrix metallopeptidase 21
type: ProteinReference
xref: uniprot F7A0Y4 596
xref: PTHR10201:SF147
organism: Xenopus tropicalis

uniprot P15379 461
type: UnificationXref
id: P15379
db: uniprot

Ser beta catenin s61 sa22 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Ser
feature location: Ser beta catenin s61 sa22 rs1 Ser
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.51
comment: MODIFICATION_RESIDUE_NAME=Ser

uniprot P41221 842
type: UnificationXref
id: P41221
db: uniprot

PTHR24027:SF267
type: RelationshipXref
id: PTHR24027:SF267
db: PANTHER Family
relationship type: By Homology

uniprot O88204 76
type: UnificationXref
id: O88204
db: uniprot

Frizzled-10
type: ProteinReference
xref: PTHR11309:SF86
xref: uniprot Q8BKG4 418
organism: Mus musculus

uniprot H2R3J3 490
type: UnificationXref
id: H2R3J3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24033:SF188
xref: uniprot A0A1D5QEP8 437
organism: Macaca mulatta

ncbitaxon 9598 18
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot I2CYF0 210
type: UnificationXref
id: I2CYF0
db: uniprot

uniprot Q7QK68 998
type: UnificationXref
id: Q7QK68
db: uniprot

Actin
type: ProteinReference
xref: uniprot E3K4I1 164
xref: PTHR11937:SF387
organism: Puccinia graminis

Amyloid beta precursor protein binding family B member 3
type: ProteinReference
xref: uniprot J9P4C6 529
organism: Canis lupus familiaris

ncbitaxon 7165 276
type: UnificationXref
id: 7165
db: ncbitaxon

CD44 intracellular fragment
type: Protein
entity reference: CD44 intracellular fragment
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A8BV70 116
type: UnificationXref
id: A8BV70
db: uniprot

Armadillo segment polarity protein
type: ProteinReference
xref: uniprot P18824 944
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3Z4K3 157
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR23277:SF69
xref: uniprot F1PCB6 704
organism: Canis lupus familiaris

uniprot P07829 219
type: UnificationXref
id: P07829
db: uniprot

uniprot F7GQW6 605
type: UnificationXref
id: F7GQW6
db: uniprot

uniprot H2Q4F7 805
type: UnificationXref
id: H2Q4F7
db: uniprot

uniprot F1Q223 475
type: UnificationXref
id: F1Q223
db: uniprot

uniprot P10984 225
type: UnificationXref
id: P10984
db: uniprot

TRUNCATION_LEFT__Presenilin-RIGHT__Presenilin_N_terminal_fragment-_Presenilin_C_terminal_fragment-_r44
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 1228
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 1227
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 1226
left: Presenilin
interaction type: TRUNCATION
right: Presenilin N-terminal fragment
right: Presenilin C-terminal fragment

Endoprotease bli-4
type: ProteinReference
xref: uniprot P51559 988
organism: Caenorhabditis elegans

AGAP001676-PA
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot Q7PXZ8 312
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: uniprot F6WBI3 15
xref: PTHR13954:SF17
organism: Macaca mulatta

Amyloid-beta A4 precursor protein-binding family B member 3
type: ProteinReference
xref: uniprot Q8R1C9 533
organism: Mus musculus

uniprot C3ZHN2 158
type: UnificationXref
id: C3ZHN2
db: uniprot

Frizzled-8
type: ProteinReference
xref: uniprot Q9H461 424
xref: PTHR11309:SF90
organism: Homo sapiens

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9V489 133
organism: Monosiga brevicollis

Nicastrin s13 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Nicastrin
stoichiometric coefficient: 1.0

Actin, alpha cardiac muscle 2
type: ProteinReference
xref: uniprot P20399 233
xref: PTHR11937:SF416
organism: Xenopus tropicalis

uniprot Q6NV44 416
type: UnificationXref
id: Q6NV44
db: uniprot

uniprot H2QKI0 618
type: UnificationXref
id: H2QKI0
db: uniprot

Frizzled class receptor 1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot F7E9U1 385
organism: Monodelphis domestica

AGAP008094-PA
type: ProteinReference
xref: PTHR16318:SF0
xref: uniprot Q7Q3Y1 925
organism: Anopheles gambiae

Putative actin-23
type: ProteinReference
xref: uniprot Q55EU6 287
xref: PTHR11937:SF154
organism: Dictyostelium discoideum

uniprot C3YP58 156
type: UnificationXref
id: C3YP58
db: uniprot

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60710 247
xref: PTHR11937:SF192
organism: Mus musculus

uniprot Q9SF12 34
type: UnificationXref
id: Q9SF12
db: uniprot

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60711 248
xref: PTHR11937:SF192
organism: Rattus norvegicus

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60712 249
xref: PTHR11937:SF192
organism: Bos taurus

uniprot E9FZ00 169
type: UnificationXref
id: E9FZ00
db: uniprot

Follistatin-related protein 1
type: ProteinReference
xref: PTHR10913:SF13
xref: uniprot Q12841 857
organism: Homo sapiens

uniprot F1PMK7 582
type: UnificationXref
id: F1PMK7
db: uniprot

uniprot Q6DJS4 676
type: UnificationXref
id: Q6DJS4
db: uniprot

uniprot E2RRZ5 711
type: UnificationXref
id: E2RRZ5
db: uniprot

Matrix metalloproteinase-20
type: ProteinReference
xref: uniprot O60882 622
xref: PTHR10201:SF125
organism: Homo sapiens

Matrix metalloproteinase-9
type: ProteinReference
xref: PTHR10201:SF30
xref: uniprot P52176 645
organism: Bos taurus

uniprot F6U055 895
type: UnificationXref
id: F6U055
db: uniprot

Actin-like protein 53D
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P45891 235
organism: Drosophila melanogaster

Frizzled class receptor 8b
type: ProteinReference
xref: PTHR11309:SF140
xref: uniprot B0S6S2 361
organism: Danio rerio

uniprot F6QL95 375
type: UnificationXref
id: F6QL95
db: uniprot

TRANSPORT_LEFT__CD44_intracellular_fragment-RIGHT__CD44_intracellular_fragment-_r78
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1209
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 1208
left: CD44 intracellular fragment
interaction type: TRANSPORT
right: CD44 intracellular fragment

BACE-1 pro-domain
type: Protein
entity reference: BACE-1 pro-domain
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N3C4 525
organism: Bos taurus

uniprot Q3SZ41 1020
type: UnificationXref
id: Q3SZ41
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Fe65-_LRP_intracellular_fragment-RIGHT__Complex__LRP_intracellular_fragment_Fe65_-_r25
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1287
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1288
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1286
left: LRP intracellular fragment
left: Fe65
interaction type: HETERODIMER_ASSOCIATION
right: Complex (LRP intracellular fragment/Fe65)

uniprot A0A2I3SSM9 889
type: UnificationXref
id: A0A2I3SSM9
db: uniprot

uniprot C3Z4K3 157
type: UnificationXref
id: C3Z4K3
db: uniprot

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60709 246
xref: PTHR11937:SF192
organism: Homo sapiens

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60706 245
xref: PTHR11937:SF192
organism: Gallus gallus

uniprot F1MAD0 50
type: UnificationXref
id: F1MAD0
db: uniprot

PARTICIPANT STOICHIOMETRY r4 1203
type: Stoichiometry
physical entity: Notch fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 1204
type: Stoichiometry
physical entity: NICD
stoichiometric coefficient: 1.0

uniprot A0A2I3T7E0 664
type: UnificationXref
id: A0A2I3T7E0
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 28

TRUNCATION_LEFT__Notch-RIGHT__Notch_C_terminal_fragment-_Notch_N_terminal_fragment-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 1224
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 1223
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 1225
left: Notch
interaction type: TRUNCATION
right: Notch C-terminal fragment
right: Notch N-terminal fragment

uniprot H2R439 973
type: UnificationXref
id: H2R439
db: uniprot

uniprot Q9QYP1 85
type: UnificationXref
id: Q9QYP1
db: uniprot

PARTICIPANT STOICHIOMETRY r4 1202
type: Stoichiometry
physical entity: Notch transmembrane fragment
stoichiometric coefficient: 1.0

uniprot H2Q943 206
type: UnificationXref
id: H2Q943
db: uniprot

uniprot Q3L254 863
type: UnificationXref
id: Q3L254
db: uniprot

uniprot F7ADK5 1034
type: UnificationXref
id: F7ADK5
db: uniprot

uniprot F6SRT1 587
type: UnificationXref
id: F6SRT1
db: uniprot

Presenilin sel-12
type: ProteinReference
xref: PTHR10202:SF13
xref: uniprot P52166 550
organism: Caenorhabditis elegans

Nectin-1
type: ProteinReference
xref: PTHR23277:SF69
xref: uniprot Q9JKF6 707
organism: Mus musculus

uniprot P43288 1058
type: UnificationXref
id: P43288
db: uniprot

uniprot A0A2I3SSR3 952
type: UnificationXref
id: A0A2I3SSR3
db: uniprot

uniprot E2QX69 955
type: UnificationXref
id: E2QX69
db: uniprot

TRUNCATION_LEFT__Complex__APP_Fe65_-RIGHT__Complex__C99_Fe65_-_APPbeta-_r51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1302
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1301
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1303
left: Complex (APP/Fe65)
interaction type: TRUNCATION
right: APPbeta
right: Complex (C99/Fe65)

HETERODIMER_ASSOCIATION_LEFT__Notch_C_terminal_fragment-_Notch_N_terminal_fragment-RIGHT__Complex__Notch_N_terminal_fragment_Notch_C_terminal_fragment_-_r2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 1213
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 1212
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 1214
left: Notch C-terminal fragment
left: Notch N-terminal fragment
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Notch N-terminal fragment/Notch C-terminal fragment)

GSK-3beta
type: ProteinReference
xref: P00175
standard name: Glycogen synthase kinase 3beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glycogen synthase kinase 3beta Synonym: Synonym not specified Accession: P00175
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.GSK-3_beta_
member entity reference: Si:dkeyp-80c12.7
member entity reference: Glycogen synthase kinase-3 beta
member entity reference: Putative glycogen synthase kinase-3 homolog
member entity reference: Glycogen synthase kinase
member entity reference: Shaggy-related protein kinase gamma
member entity reference: Glycogen synthase kinase 3 beta
member entity reference: Shaggy-related protein kinase iota
member entity reference: Shaggy-related protein kinase eta
member entity reference: Protein kinase gsk31
member entity reference: Uncharacterized protein
member entity reference: Protein kinase gsk3
member entity reference: Os01g0252100 protein
member entity reference: Shaggy-related protein kinase epsilon
member entity reference: Shaggy-related protein kinase beta
member entity reference: Glycogen synthase kinase-3 beta isoform 1
member entity reference: Serine/threonine-protein kinase RIM11/MSD1
member entity reference: Shaggy-related protein kinase theta
member entity reference: Glycogen synthase kinase-3
member entity reference: Os01g0296100 protein
member entity reference: Shaggy-related protein kinase delta
member entity reference: Glycogen synthase kinase 3
member entity reference: Shaggy-related protein kinase alpha
member entity reference: Os10g0521700 protein

uniprot P63239 989
type: UnificationXref
id: P63239
db: uniprot

Protein CBR-EGL-20
type: ProteinReference
xref: uniprot A8WV58 745
xref: PTHR12027:SF70
organism: Caenorhabditis briggsae

RBPJL isoform 1
type: ProteinReference
xref: uniprot A0A2J8MK73 1002
organism: Pan troglodytes

PTHR10665:SF0
type: RelationshipXref
id: PTHR10665:SF0
db: PANTHER Family
relationship type: By Homology

PTHR10665:SF2
type: RelationshipXref
id: PTHR10665:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q39012 1065
type: UnificationXref
id: Q39012
db: uniprot

uniprot C3ZTX6 161
type: UnificationXref
id: C3ZTX6
db: uniprot

PTHR10665:SF3
type: RelationshipXref
id: PTHR10665:SF3
db: PANTHER Family
relationship type: By Homology

Frizzled-3
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot F6QL95 375
organism: Macaca mulatta

uniprot A9TVP1 129
type: UnificationXref
id: A9TVP1
db: uniprot

Fe65 s10 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fe65
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: uniprot A0A1D5QFE1 733
xref: PTHR12027:SF93
organism: Macaca mulatta

uniprot P20399 233
type: UnificationXref
id: P20399
db: uniprot

uniprot F1PS94 441
type: UnificationXref
id: F1PS94
db: uniprot

uniprot P53690 646
type: UnificationXref
id: P53690
db: uniprot

PARTICIPANT STOICHIOMETRY r61 1269
type: Stoichiometry
physical entity: Complex (Nectin 1alpha/Afadin/ alphacatenin/actin/ beta-catenin/gammacatenin/ E-cadherin)
stoichiometric coefficient: 1.0

uniprot F7F147 599
type: UnificationXref
id: F7F147
db: uniprot

Actin alpha 2, smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot Q6DHS1 300
organism: Danio rerio

APPbeta
type: ProteinReference
xref: P00151
standard name: Amyloid precursor protein beta-ectodomain
comment: ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor protein beta-ectodomain Synonym: Synonym not specified Accession: P00151
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.APP_beta_
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta A4 protein
member entity reference: Amyloid-beta precursor protein

uniprot O75460 20
type: UnificationXref
id: O75460
db: uniprot

Frizzled-10
type: ProteinReference
xref: uniprot Q9PWH2 428
xref: PTHR11309:SF86
organism: Gallus gallus

Presenilin-1
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot Q6RH31 555
organism: Canis lupus familiaris

uniprot A0A140T847 731
type: UnificationXref
id: A0A140T847
db: uniprot

Serine/threonine-protein kinase/endoribonuclease IRE1
type: ProteinReference
xref: PTHR13954:SF6
xref: uniprot P32361 25
organism: Saccharomyces cerevisiae

Matrix metalloprotease
type: ProteinReference
xref: P00130
comment: ENTITY_REFERENCE_NOTES=Long Name: Matrix metalloprotease Synonym: Synonym not specified Accession: P00130
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Matrix_br_metalloprotease
member entity reference: Uncharacterized protein
member entity reference: Interstitial collagenase
member entity reference: Matrix metallopeptidase 2
member entity reference: Matrix metallopeptidase 24
member entity reference: Matrix metalloproteinase-9
member entity reference: MMP24 isoform 1
member entity reference: Matrix metalloproteinase-21
member entity reference: MMP9 isoform 1
member entity reference: Matrix metalloproteinase-14
member entity reference: MMP21 isoform 1
member entity reference: MMP20 isoform 1
member entity reference: Matrix metalloproteinase-B
member entity reference: Neutrophil collagenase
member entity reference: Macrophage metalloelastase
member entity reference: Collagenase 3
member entity reference: Matrix metalloproteinase-15
member entity reference: Matrix metallopeptidase 21
member entity reference: Matrix metallopeptidase 20
member entity reference: Matrix metalloproteinase-20
member entity reference: Matrix metalloproteinase-24
member entity reference: Matrix metallopeptidase 15
member entity reference: Matrix metallopeptidase 13
member entity reference: MMP27 isoform 1
member entity reference: 72 kDa type IV collagenase
member entity reference: Matrix metalloproteinase-16
member entity reference: Matrix metallopeptidase 27
member entity reference: MMP2 isoform 1
member entity reference: Matrix metalloproteinase-23
member entity reference: Matrix metalloproteinase-27
member entity reference: Matrix metallopeptidase 16
member entity reference: Matrix metalloproteinase-14 preproprotein
member entity reference: Matrilysin
member entity reference: Matrix metalloproteinase-25
member entity reference: Matrix metalloproteinase-19
member entity reference: MMP15 isoform 1
member entity reference: Matrix metallopeptidase 13 (collagenase 3)-like
member entity reference: MMP14 isoform 1
member entity reference: MMP8 isoform 1

PARTICIPANT STOICHIOMETRY r70 1240
type: Stoichiometry
physical entity: Wnt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r70 1241
type: Stoichiometry
physical entity: Frizzled
stoichiometric coefficient: 1.0

PTHR13954:SF15
type: RelationshipXref
id: PTHR13954:SF15
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r70 1242
type: Stoichiometry
physical entity: Complex (Wnt/Frizzled)
stoichiometric coefficient: 1.0

uniprot A0A2I3TS83 101
type: UnificationXref
id: A0A2I3TS83
db: uniprot

Collagenase 3
type: ProteinReference
xref: PTHR10201:SF165
xref: uniprot P45452 639
organism: Homo sapiens

PTHR13954:SF17
type: RelationshipXref
id: PTHR13954:SF17
db: PANTHER Family
relationship type: By Homology

uniprot P60711 248
type: UnificationXref
id: P60711
db: uniprot

Capacitative calcium channels
type: ProteinReference
xref: P00124
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.ION_CHANNEL.Capacitative_br_calcium_br_channels
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES=Long Name: Capacitative calcium channels Synonym: Synonym not specified Accession: P00124
member entity reference: Transient receptor potential cation channel subfamily C member 3
member entity reference: Short transient receptor potential channel 4
member entity reference: Transient-receptor-potential-like protein
member entity reference: Uncharacterized protein
member entity reference: Short transient receptor potential channel 6
member entity reference: Transient receptor potential cation channel, subfamily C, member 1
member entity reference: Transient receptor potential cation channel subfamily C member 6
member entity reference: Transient receptor potential cation channel, subfamily C, member 5
member entity reference: Transient receptor potential cation channel subfamily C member 7
member entity reference: TRPC3 isoform 2
member entity reference: Short transient receptor potential channel 5
member entity reference: Transient receptor potential cation channel subfamily C member 4
member entity reference: Transient receptor potential protein
member entity reference: Short transient receptor potential channel 3
member entity reference: Short transient receptor potential channel 2
member entity reference: Transient receptor potential cation channel subfamily C member 1 isoform alpha
member entity reference: Transient receptor potential cation channel subfamily C member 1
member entity reference: TRPC7 isoform 1
member entity reference: Short transient receptor potential channel 1
member entity reference: TRPC4 isoform 1
member entity reference: TRP (Transient receptor potential) channel family
member entity reference: Transient receptor potential-gamma protein
member entity reference: Short transient receptor potential channel 7
member entity reference: Transient receptor potential cation channel, subfamily C, member 7b
member entity reference: Transient receptor potential cation channel, subfamily C, member 7
member entity reference: Transient receptor potential Ca2+ channel 6A

uniprot A0A0G2K2H4 6
type: UnificationXref
id: A0A0G2K2H4
db: uniprot

uniprot F1MW26 577
type: UnificationXref
id: F1MW26
db: uniprot

uniprot A0A1D5PEJ9 353
type: UnificationXref
id: A0A1D5PEJ9
db: uniprot

Presenilin
type: ProteinReference
xref: PTHR10202:SF18
xref: uniprot F7AGU8 539
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GG37 603
xref: PTHR10201:SF137
organism: Macaca mulatta

uniprot A7SCN8 113
type: UnificationXref
id: A7SCN8
db: uniprot

uniprot O70421 400
type: UnificationXref
id: O70421
db: uniprot

uniprot Q4JIM4 553
type: UnificationXref
id: Q4JIM4
db: uniprot

Neuroendocrine convertase 2
type: ProteinReference
xref: uniprot P28841 983
organism: Rattus norvegicus

uniprot X1WEJ5 887
type: UnificationXref
id: X1WEJ5
db: uniprot

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 138

uniprot B3RX77 139
type: UnificationXref
id: B3RX77
db: uniprot

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot P28840 982
organism: Rattus norvegicus

uniprot P22725 831
type: UnificationXref
id: P22725
db: uniprot

Protein Wnt-9b
type: ProteinReference
xref: uniprot O35468 820
xref: PTHR12027:SF84
organism: Mus musculus

Neuroendocrine convertase 2
type: ProteinReference
xref: uniprot G5ECN9 968
organism: Caenorhabditis elegans

NICD
type: Protein
entity reference: NICD
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase ppk4
type: ProteinReference
xref: PTHR13954:SF6
xref: uniprot O94537 23
organism: Schizosaccharomyces pombe

PTHR13954:SF27
type: RelationshipXref
id: PTHR13954:SF27
db: PANTHER Family
relationship type: By Homology

Complex (APP/Fe65)
type: Complex
component stoichiometry: APP s24 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fe65 s25 sa31 STOICHIOMETRY ID COMPLEX
component: Fe65
component: APP
feature: COMPLEX BINDING FEATURE s171 a208 1171
feature: COMPLEX BINDING FEATURE s171 a208 1169
cellular location: cytosol

Matrix metalloproteinase-25
type: ProteinReference
xref: uniprot Q3U435 725
organism: Mus musculus

Frizzled class receptor 4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot K7AZD4 396
organism: Pan troglodytes

Presenilin N-terminal fragment
type: ProteinReference
xref: P00140
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Presenilin_br_N-terminal_br_fragment
comment: ENTITY_REFERENCE_NOTES=Long Name: Presenilin N-terminal fragment Synonym: Synonym not specified Accession: P00140
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
member entity reference: Presenilin-2
member entity reference: Presenilin
member entity reference: Presenilin-like protein At2g29900
member entity reference: Presenilin-1
member entity reference: Presenilin spe-4
member entity reference: Presenilin sel-12
member entity reference: Presenilin homolog
member entity reference: Presenilin-like protein At1g08700
member entity reference: Presenilin hop-1

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EZ48 386
xref: PTHR11309:SF86
organism: Macaca mulatta

Furin
type: ProteinReference
xref: PTHR42884:SF1
xref: uniprot B0JYR0 953
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR10117:SF8
xref: uniprot F1NJJ8 472
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PGQ1 1052
xref: PTHR24057:SF8
organism: Monodelphis domestica

uniprot P28465 838
type: UnificationXref
id: P28465
db: uniprot

uniprot Q9WVB9 701
type: UnificationXref
id: Q9WVB9
db: uniprot

PARTICIPANT STOICHIOMETRY r61 1271
type: Stoichiometry
physical entity: Nectin 1alpha N-terminal fragment
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r61 1270
type: Stoichiometry
physical entity: Nectin 1alpha C-terminal fragment
stoichiometric coefficient: 1.0

CSL
type: Protein
entity reference: CSL
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

AICD s34 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GL52 442
xref: PTHR24044:SF415
organism: Macaca mulatta

uniprot O88572 77
type: UnificationXref
id: O88572
db: uniprot

uniprot A0A1D5R1C6 43
type: UnificationXref
id: A0A1D5R1C6
db: uniprot

uniprot Q9ULW2 432
type: UnificationXref
id: Q9ULW2
db: uniprot

Transient receptor potential cation channel subfamily C member 1 isoform alpha
type: ProteinReference
xref: PTHR10117:SF56
xref: uniprot Q6DMS2 501
organism: Gallus gallus

Catenin beta-1
type: ProteinReference
xref: uniprot Q9WU82 949
xref: PTHR45976:SF4
organism: Rattus norvegicus

Recombination signal binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: uniprot E2QV83 1008
xref: PTHR10665:SF3
organism: Canis lupus familiaris

uniprot E2RH98 768
type: UnificationXref
id: E2RH98
db: uniprot

uniprot A0A0R4IFF8 340
type: UnificationXref
id: A0A0R4IFF8
db: uniprot

Receptor protein-tyrosine kinase
type: ProteinReference
xref: PTHR24416:SF90
xref: uniprot F6ZSZ9 88
organism: Monodelphis domestica

Matrix metallopeptidase 2
type: ProteinReference
xref: PTHR10201:SF29
xref: uniprot F7E8W8 597
organism: Xenopus tropicalis

uniprot Q9WTR0 660
type: UnificationXref
id: Q9WTR0
db: uniprot

Neurogenic locus notch homolog protein 4
type: ProteinReference
xref: uniprot Q99466 455
xref: PTHR24044:SF450
organism: Homo sapiens

uniprot F7D992 344
type: UnificationXref
id: F7D992
db: uniprot

PARTICIPANT STOICHIOMETRY r44 1228
type: Stoichiometry
physical entity: Presenilin C-terminal fragment
stoichiometric coefficient: 1.0

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q75D00 309
organism: Ashbya gossypii

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 24

PARTICIPANT STOICHIOMETRY r44 1227
type: Stoichiometry
physical entity: Presenilin N-terminal fragment
stoichiometric coefficient: 1.0

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 310

uniprot P83967 274
type: UnificationXref
id: P83967
db: uniprot

uniprot P53489 239
type: UnificationXref
id: P53489
db: uniprot

uniprot H2Q2F4 804
type: UnificationXref
id: H2Q2F4
db: uniprot

Histone acetyltransferase
type: ProteinReference
xref: uniprot A0A3Q1MIR9 709
xref: PTHR10615:SF183
organism: Bos taurus

LRP C-terminal fragment
type: ProteinReference
xref: P00112
comment: ENTITY_REFERENCE_NOTES=Long Name: LRP C-terminal fragment Synonym: Synonym not specified Accession: P00112
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.LRP_br_C-terminal_br_fragment
member entity reference: Low-density lipoprotein receptor-related protein 1B
member entity reference: LDL receptor related protein 1
member entity reference: Low-density lipoprotein receptor-related protein 6
member entity reference: Low-density lipoprotein receptor-related protein
member entity reference: LDL receptor-related protein 1
member entity reference: LDL receptor related protein 3
member entity reference: LDL receptor related protein 6
member entity reference: LDL receptor related protein 4
member entity reference: Low-density lipoprotein receptor-related protein 2
member entity reference: Uncharacterized protein
member entity reference: Low-density lipoprotein receptor-related protein 3
member entity reference: LDL receptor related protein 1B
member entity reference: Low-density lipoprotein receptor-related protein 5
member entity reference: Low-density lipoprotein receptor-related protein 4
member entity reference: Low density lipoprotein receptor-related protein 3
member entity reference: Prolow-density lipoprotein receptor-related protein 1
member entity reference: LDL receptor related protein 2

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa37 1156
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r78 1209
type: Stoichiometry
physical entity: CD44 intracellular fragment
stoichiometric coefficient: 1.0

Matrix metalloproteinase-9
type: ProteinReference
xref: uniprot F1PYF5 584
xref: PTHR10201:SF30
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r78 1208
type: Stoichiometry
physical entity: CD44 intracellular fragment
stoichiometric coefficient: 1.0

PTHR10202:SF18
type: RelationshipXref
id: PTHR10202:SF18
db: PANTHER Family
relationship type: By Homology

uniprot F7H113 62
type: UnificationXref
id: F7H113
db: uniprot

PTHR10202:SF13
type: RelationshipXref
id: PTHR10202:SF13
db: PANTHER Family
relationship type: By Homology

PTHR10202:SF14
type: RelationshipXref
id: PTHR10202:SF14
db: PANTHER Family
relationship type: By Homology

ncbitaxon 227321 232
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot P0DM42 223
type: UnificationXref
id: P0DM42
db: uniprot

Protein CBR-CWN-2
type: ProteinReference
xref: PTHR12027:SF77
xref: uniprot A8WV10 744
organism: Caenorhabditis briggsae

uniprot V6CLJ5 1022
type: UnificationXref
id: V6CLJ5
db: uniprot

PTHR24027:SF319
type: RelationshipXref
id: PTHR24027:SF319
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r44 1226
type: Stoichiometry
physical entity: Presenilin
stoichiometric coefficient: 1.0

actin s58 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: actin
stoichiometric coefficient: 1.0

uniprot F7GL52 442
type: UnificationXref
id: F7GL52
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF446
xref: uniprot F6R9F4 183
organism: Monodelphis domestica

Furin-like protease kpc-1
type: ProteinReference
xref: uniprot O17798 975
organism: Caenorhabditis elegans

uniprot H2Q4U8 1025
type: UnificationXref
id: H2Q4U8
db: uniprot

uniprot F7GAV2 90
type: UnificationXref
id: F7GAV2
db: uniprot

uniprot B3RKR4 137
type: UnificationXref
id: B3RKR4
db: uniprot

uniprot O35516 447
type: UnificationXref
id: O35516
db: uniprot

uniprot P09803 346
type: UnificationXref
id: P09803
db: uniprot

PTHR10201:SF239
type: RelationshipXref
id: PTHR10201:SF239
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__NICD-_CSL-RIGHT__Complex__CSL_NICD_-_r7
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1185
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1186
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1184
left: CSL
left: NICD
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CSL/NICD)

PTHR10201:SF237
type: RelationshipXref
id: PTHR10201:SF237
db: PANTHER Family
relationship type: By Homology

uniprot F1PUS1 960
type: UnificationXref
id: F1PUS1
db: uniprot

uniprot G5EG05 802
type: UnificationXref
id: G5EG05
db: uniprot

Actin, indirect flight muscle
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P83967 274
organism: Drosophila melanogaster

uniprot Q94IZ2 1068
type: UnificationXref
id: Q94IZ2
db: uniprot

uniprot A6H6X8 743
type: UnificationXref
id: A6H6X8
db: uniprot

beta catenin s70 sa41 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PTHR10202:SF26
type: RelationshipXref
id: PTHR10202:SF26
db: PANTHER Family
relationship type: By Homology

uniprot Q9WUD6 884
type: UnificationXref
id: Q9WUD6
db: uniprot

uniprot Q60838 698
type: UnificationXref
id: Q60838
db: uniprot

PTHR10202:SF24
type: RelationshipXref
id: PTHR10202:SF24
db: PANTHER Family
relationship type: By Homology

PTHR10202:SF25
type: RelationshipXref
id: PTHR10202:SF25
db: PANTHER Family
relationship type: By Homology

Proprotein convertase subtilisin/kexin type 6
type: ProteinReference
xref: uniprot F1PUS1 960
organism: Canis lupus familiaris

Actin-related protein 2-A
type: ProteinReference
xref: uniprot Q7SXW6 313
xref: PTHR11937:SF149
organism: Danio rerio

uniprot E2QXY7 163
type: UnificationXref
id: E2QXY7
db: uniprot

CD44 antigen
type: ProteinReference
xref: PTHR10225:SF6
xref: uniprot P26051 463
organism: Rattus norvegicus

Gamma-secretase subunit PEN-2
type: ProteinReference
xref: uniprot J9P0J9 921
xref: PTHR16318:SF0
organism: Canis lupus familiaris

uniprot Q09175 991
type: UnificationXref
id: Q09175
db: uniprot

Afadin
type: ProteinReference
xref: uniprot P55196 912
xref: PTHR10398:SF2
organism: Homo sapiens

LRP intracellular fragment
type: Protein
entity reference: LRP intracellular fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa7 1162
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P63270 262
type: UnificationXref
id: P63270
db: uniprot

uniprot O00755 817
type: UnificationXref
id: O00755
db: uniprot

Histone acetyltransferase
type: ProteinReference
xref: uniprot H2QDD8 715
organism: Pan troglodytes

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF93
xref: uniprot H2RAM0 811
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR22722:SF5
xref: uniprot F7H113 62
organism: Macaca mulatta

Protein Wnt
type: ProteinReference
xref: uniprot A4ZGP0 742
xref: PTHR12027:SF82
organism: Xenopus tropicalis

Histone acetyltransferase
type: ProteinReference
xref: uniprot Q08DP5 718
organism: Bos taurus

Short transient receptor potential channel 1
type: ProteinReference
xref: PTHR10117:SF56
xref: uniprot F7EA78 485
organism: Macaca mulatta

a153_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

uniprot Q6XNL8 308
type: UnificationXref
id: Q6XNL8
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F7FK62 794
xref: PTHR12027:SF94
organism: Ornithorhynchus anatinus

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 230

Matrix metalloproteinase-16
type: ProteinReference
xref: uniprot Q9WTR0 660
xref: PTHR10201:SF26
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot F6PWM3 373
organism: Monodelphis domestica

uniprot P31695 449
type: UnificationXref
id: P31695
db: uniprot

uniprot P49841 1060
type: UnificationXref
id: P49841
db: uniprot

uniprot Q7QDV6 417
type: UnificationXref
id: Q7QDV6
db: uniprot

uniprot E2RTG8 769
type: UnificationXref
id: E2RTG8
db: uniprot

Complex (Notch N-terminal fragment/Notch C-terminal fragment)
type: Complex
component stoichiometry: Notch C terminal fragment s40 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Notch N terminal fragment s37 sa1 STOICHIOMETRY ID COMPLEX
component: Notch C-terminal fragment
component: Notch N-terminal fragment
feature: COMPLEX BINDING FEATURE s14 a19 1159
feature: COMPLEX BINDING FEATURE s14 a19 1157
cellular location: cytosol

uniprot Q9UM47 458
type: UnificationXref
id: Q9UM47
db: uniprot

Alpha-cardiac actin
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot F7F210 200
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r52 1300
type: Stoichiometry
physical entity: Complex (AICD/Fe65/ Tip60)
stoichiometric coefficient: 1.0

Receptor tyrosine-protein kinase erbB-4
type: ProteinReference
xref: uniprot Q61527 92
xref: PTHR24416:SF90
organism: Mus musculus

actin, muscle-like
type: ProteinReference
xref: uniprot A0A1W2WEN5 97
organism: Ciona intestinalis

actin
type: Protein
entity reference: actin
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa21 1138
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Presenilin N terminal fragment s17 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Presenilin N-terminal fragment
stoichiometric coefficient: 1.0

Actin, alpha, cardiac muscle 1a
type: ProteinReference
xref: PTHR11937:SF150
xref: uniprot F1RCB6 178
organism: Danio rerio

uniprot P23188 979
type: UnificationXref
id: P23188
db: uniprot

uniprot F7GNE5 966
type: UnificationXref
id: F7GNE5
db: uniprot

ncbitaxon 44689 218
type: UnificationXref
id: 44689
db: ncbitaxon

Actin
type: ProteinReference
xref: uniprot Q67G20 299
organism: Oryza sativa

PTHR10913:SF13
type: RelationshipXref
id: PTHR10913:SF13
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF389
type: RelationshipXref
id: PTHR11937:SF389
db: PANTHER Family
relationship type: By Homology

uniprot Q8BFZ3 317
type: UnificationXref
id: Q8BFZ3
db: uniprot

Protein Wnt-5b
type: ProteinReference
xref: uniprot Q92050 871
xref: PTHR12027:SF87
organism: Danio rerio

uniprot Q9DBR4 535
type: UnificationXref
id: Q9DBR4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NEW3 670
organism: Gallus gallus

PTHR11937:SF387
type: RelationshipXref
id: PTHR11937:SF387
db: PANTHER Family
relationship type: By Homology

CD44 intracellular fragment
type: Protein
entity reference: CD44 intracellular fragment
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P63259 256
type: UnificationXref
id: P63259
db: uniprot

uniprot Q62956 93
type: UnificationXref
id: Q62956
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot E2RDT2 767
organism: Canis lupus familiaris

uniprot O45815 212
type: UnificationXref
id: O45815
db: uniprot

uniprot H2Q772 390
type: UnificationXref
id: H2Q772
db: uniprot

Matrix metallopeptidase 13
type: ProteinReference
xref: PTHR10201:SF165
xref: uniprot A0A2I3SHB6 568
organism: Pan troglodytes

MODULATION
type: Control
xref: MODULATION
controlled: Gene transcription
controller: Complex (CSL/NICD)

Matrix metalloproteinase-14
type: ProteinReference
xref: uniprot P53690 646
xref: PTHR10201:SF24
organism: Mus musculus

Frizzled-4
type: ProteinReference
xref: PTHR11309:SF23
xref: uniprot Q61088 411
organism: Mus musculus

uniprot E2RSE6 957
type: UnificationXref
id: E2RSE6
db: uniprot

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot Q92048 870
organism: Danio rerio

Frizzled-6
type: ProteinReference
xref: PTHR11309:SF75
xref: uniprot Q61089 412
organism: Mus musculus

HETERODIMER_ASSOCIATION_LEFT__Complex__AICD_Fe65_-_Tip60-RIGHT__Complex__AICD_Fe65__Tip60_-_r52
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 1300
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 1299
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 1298
left: Complex (AICD/Fe65)
left: Tip60
interaction type: HETERODIMER_ASSOCIATION
right: Complex (AICD/Fe65/ Tip60)

Frizzled-3
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot Q61086 410
organism: Mus musculus

uniprot Q9H1J5 876
type: UnificationXref
id: Q9H1J5
db: uniprot

MMP14 isoform 1
type: ProteinReference
xref: uniprot H2Q7Z4 615
xref: PTHR10201:SF24
organism: Pan troglodytes

LDL receptor related protein 4
type: ProteinReference
xref: PTHR24270:SF5
xref: uniprot J9P7Q4 71
organism: Canis lupus familiaris

Shaggy-related protein kinase gamma
type: ProteinReference
xref: uniprot P43289 1059
organism: Arabidopsis thaliana

beta-catenin
type: Protein
entity reference: beta-catenin
feature: beta catenin s122 a153 rs2
feature: Ser beta catenin s122 a153 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A2HNG1 105
type: UnificationXref
id: A2HNG1
db: uniprot

Shaggy-related protein kinase alpha
type: ProteinReference
xref: uniprot P43288 1058
organism: Arabidopsis thaliana

PTHR11937:SF397
type: RelationshipXref
id: PTHR11937:SF397
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 218

uniprot P12830 348
type: UnificationXref
id: P12830
db: uniprot

uniprot F7CQE8 1024
type: UnificationXref
id: F7CQE8
db: uniprot

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: uniprot P26016 981
xref: PTHR42884:SF3
organism: Drosophila melanogaster

uniprot Q924A0 902
type: UnificationXref
id: Q924A0
db: uniprot

uniprot W4XTP5 328
type: UnificationXref
id: W4XTP5
db: uniprot

uniprot F7H7P8 797
type: UnificationXref
id: F7H7P8
db: uniprot

ADAM metallopeptidase domain 17
type: ProteinReference
xref: uniprot F1PFZ9 915
xref: PTHR45702:SF6
organism: Canis lupus familiaris

uniprot F7HEW6 798
type: UnificationXref
id: F7HEW6
db: uniprot

PTHR16318:SF0
type: RelationshipXref
id: PTHR16318:SF0
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10373:SF25
xref: uniprot F6U055 895
organism: Macaca mulatta

uniprot H2QD96 807
type: UnificationXref
id: H2QD96
db: uniprot

TRUNCATION_LEFT__Erb_B4_C_terminal_fragment-RIGHT__Erb_B4_transmembrane_fragment-_Erb_B4_intracellular_fragment-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 1192
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 1193
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 1194
left: Erb-B4 C-terminal fragment
interaction type: TRUNCATION
right: Erb-B4 intracellular fragment
right: Erb-B4 transmembrane fragment

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 283

Presenilin N-terminal fragment
type: Protein
entity reference: Presenilin N-terminal fragment
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa28 1118
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

uniprot Q9U2Q9 1073
type: UnificationXref
id: Q9U2Q9
db: uniprot

Aph-1
type: Protein
entity reference: Aph-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa46 1124
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q667 614
type: UnificationXref
id: H2Q667
db: uniprot

Actin, alpha sarcomeric/skeletal
type: ProteinReference
xref: PTHR11937:SF240
xref: uniprot Q6P8G3 306
organism: Xenopus tropicalis

uniprot H2QY65 445
type: UnificationXref
id: H2QY65
db: uniprot

Fe65
type: Protein
entity reference: Fe65
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa10 1168
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Furin
type: ProteinReference
xref: PTHR42884:SF1
xref: uniprot P23188 979
organism: Mus musculus

uniprot A0A0G2K0H3 42
type: UnificationXref
id: A0A0G2K0H3
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 111

Low-density lipoprotein receptor-related protein 5
type: ProteinReference
xref: uniprot O75197 74
xref: PTHR46513:SF16
organism: Homo sapiens

Presenilin C-terminal fragment
type: ProteinReference
xref: P00155
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: Presenilin C-terminal fragment Synonym: Synonym not specified Accession: P00155
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Presenilin_br_C-terminal_br_fragment
member entity reference: Presenilin-2
member entity reference: Presenilin
member entity reference: Presenilin-like protein At2g29900
member entity reference: Presenilin-1
member entity reference: Presenilin spe-4
member entity reference: Presenilin sel-12
member entity reference: Presenilin homolog
member entity reference: Presenilin-like protein At1g08700
member entity reference: Presenilin hop-1

uniprot P41546 675
type: UnificationXref
id: P41546
db: uniprot

Nicastrin
type: Protein
entity reference: Nicastrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa45 1122
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot C3YC50 154
type: UnificationXref
id: C3YC50
db: uniprot

uniprot H2QD74 391
type: UnificationXref
id: H2QD74
db: uniprot

Complex (C99/Fe65)
type: Complex
component stoichiometry: C99 s26 sa32 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fe65 s27 sa33 STOICHIOMETRY ID COMPLEX
component: Fe65
component: C99
feature: COMPLEX BINDING FEATURE s173 a211 1089
feature: COMPLEX BINDING FEATURE s173 a211 1087
cellular location: cytosol

uniprot A8JAV1 118
type: UnificationXref
id: A8JAV1
db: uniprot

Shaggy-related protein kinase delta
type: ProteinReference
xref: uniprot Q9FVS6 1070
organism: Arabidopsis thaliana

PTHR10373:SF25
type: RelationshipXref
id: PTHR10373:SF25
db: PANTHER Family
relationship type: By Homology

uniprot P68134 268
type: UnificationXref
id: P68134
db: uniprot

CDH1 isoform 1
type: ProteinReference
xref: PTHR24027:SF319
xref: uniprot A0A2J8Q404 341
organism: Pan troglodytes

uniprot Q8VI56 80
type: UnificationXref
id: Q8VI56
db: uniprot

TRUNCATION_LEFT__Pro_BACE_1-RIGHT__BACE_1-_BACE_1_pro_domain-_r43
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 1231
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 1232
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 1233
left: Pro-BACE-1
interaction type: TRUNCATION
right: BACE-1 pro-domain
right: BACE-1

uniprot M0R7Q3 1012
type: UnificationXref
id: M0R7Q3
db: uniprot

HAC1
type: ProteinReference
xref: P00131
standard name: Tripartite motif-containing protein 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.HAC1
comment: ENTITY_REFERENCE_NOTES=Long Name: Tripartite motif-containing protein 3 Synonym: BERP,RNF22,RNF97 Accession: P00131
member entity reference: Tripartite motif-containing protein 2
member entity reference: Tripartite motif containing 3
member entity reference: Tripartite motif-containing protein 3
member entity reference: Uncharacterized protein
member entity reference: TRIM2 isoform 7
member entity reference: TRIM3 protein
member entity reference: Tripartite motif-containing 2
member entity reference: RING finger protein 22
member entity reference: Transcriptional activator HAC1

Gamma-secretase subunit APH1-like
type: ProteinReference
xref: uniprot Q8L9G7 1044
xref: PTHR12889:SF0
organism: Arabidopsis thaliana

PTHR10373:SF11
type: RelationshipXref
id: PTHR10373:SF11
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3RVR8 44
type: UnificationXref
id: A0A2I3RVR8
db: uniprot

Serine/threonine-protein kinase/endoribonuclease IRE1b
type: ProteinReference
xref: PTHR13954:SF27
xref: uniprot Q93VJ2 29
organism: Arabidopsis thaliana

uniprot P56704 853
type: UnificationXref
id: P56704
db: uniprot

Frizzled-8
type: ProteinReference
xref: uniprot Q61091 414
xref: PTHR11309:SF90
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR10201:SF151
xref: uniprot F6WYF2 591
organism: Macaca mulatta

Frizzled-7
type: ProteinReference
xref: uniprot Q61090 413
xref: PTHR11309:SF31
organism: Mus musculus

Short transient receptor potential channel 5
type: ProteinReference
xref: PTHR10117:SF76
xref: uniprot Q9QX29 508
organism: Mus musculus

uniprot Q9HCS4 903
type: UnificationXref
id: Q9HCS4
db: uniprot

uniprot Q28GC2 948
type: UnificationXref
id: Q28GC2
db: uniprot

Abeta
type: Protein
entity reference: Abeta
comment: SPECIES_TYPE=PROTEIN

uniprot F6WCX0 896
type: UnificationXref
id: F6WCX0
db: uniprot

E cadherin s68 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: E-cadherin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RKL5 951
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot H3FCG4 209
xref: PTHR11937:SF471
organism: Pristionchus pacificus

ncbitaxon 39947 28
type: UnificationXref
id: 39947
db: ncbitaxon

72 kDa type IV collagenase
type: ProteinReference
xref: PTHR10201:SF29
xref: uniprot P33436 636
organism: Rattus norvegicus

Low-density lipoprotein receptor-related protein 4
type: ProteinReference
xref: PTHR24270:SF5
xref: uniprot Q8VI56 80
organism: Mus musculus

Neurogenic locus notch homolog protein 3
type: ProteinReference
xref: uniprot Q61982 453
xref: PTHR45836:SF17
organism: Mus musculus

uniprot F7F210 200
type: UnificationXref
id: F7F210
db: uniprot

uniprot Q7ZVF9 315
type: UnificationXref
id: Q7ZVF9
db: uniprot

PTHR24270:SF23
type: RelationshipXref
id: PTHR24270:SF23
db: PANTHER Family
relationship type: By Homology

PTHR24270:SF22
type: RelationshipXref
id: PTHR24270:SF22
db: PANTHER Family
relationship type: By Homology

uniprot A0A1W2WEN5 97
type: UnificationXref
id: A0A1W2WEN5
db: uniprot

Putative actin-5
type: ProteinReference
xref: uniprot Q8RYC2 321
organism: Arabidopsis thaliana

Low-density lipoprotein receptor-related protein
type: ProteinReference
xref: PTHR24270:SF12
xref: uniprot F1PCS0 53
organism: Canis lupus familiaris

uniprot F1NJJ8 472
type: UnificationXref
id: F1NJJ8
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q8R1C9 533
type: UnificationXref
id: Q8R1C9
db: uniprot

TRANSPORT
type: InteractionVocabulary

Notch C-terminal fragment
type: ProteinReference
xref: P00120
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Notch_br_C-terminal_br_fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: Notch C-terminal fragment Synonym: Synonym not specified Accession: P00120
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 1
member entity reference: Neurogenic locus notch homolog protein 3
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Notch 4
member entity reference: Notch 3
member entity reference: Neurogenic locus Notch protein
member entity reference: Notch 1
member entity reference: NOTCH3 isoform 1
member entity reference: NOTCH1 isoform 1

uniprot Q5KP06 292
type: UnificationXref
id: Q5KP06
db: uniprot

GO GO:0005829 5
type: UnificationXref
id: GO:0005829
db: GO

uniprot A0A0G2K6Q8 730
type: UnificationXref
id: A0A0G2K6Q8
db: uniprot

PTHR11937:SF359
type: RelationshipXref
id: PTHR11937:SF359
db: PANTHER Family
relationship type: By Homology

alphacatenin s48 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: alphacatenin
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: uniprot H2Q4F7 805
xref: PTHR12027:SF7
organism: Pan troglodytes

Actin
type: ProteinReference
xref: uniprot A7ETS6 107
xref: PTHR11937:SF387
organism: Sclerotinia sclerotiorum

MODULATION
type: Control
xref: MODULATION
controlled: Gene transcription
controller: Erb-B4 intracellular fragment

Serine/threonine-protein kinase/endoribonuclease IRE1
type: ProteinReference
xref: PTHR13954:SF6
xref: uniprot Q7XIT1 27
organism: Oryza sativa

uniprot Q99PW6 726
type: UnificationXref
id: Q99PW6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF31
xref: uniprot F7A659 382
organism: Monodelphis domestica

uniprot F1MJS2 893
type: UnificationXref
id: F1MJS2
db: uniprot

uniprot Q6RH31 555
type: UnificationXref
id: Q6RH31
db: uniprot

uniprot F1PCB6 704
type: UnificationXref
id: F1PCB6
db: uniprot

PTHR10373:SF32
type: RelationshipXref
id: PTHR10373:SF32
db: PANTHER Family
relationship type: By Homology

PTHR10373:SF33
type: RelationshipXref
id: PTHR10373:SF33
db: PANTHER Family
relationship type: By Homology

Transient receptor potential cation channel subfamily C member 1
type: ProteinReference
xref: uniprot E2R6Q9 470
xref: PTHR10117:SF56
organism: Canis lupus familiaris

Matrix metallopeptidase 13 (collagenase 3)-like
type: ProteinReference
xref: PTHR10201:SF165
xref: uniprot F6SRT1 587
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot F1A175 174
organism: Dictyostelium purpureum

uniprot F1N4C0 773
type: UnificationXref
id: F1N4C0
db: uniprot

Nicastrin
type: Protein
entity reference: Nicastrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa25 1112
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0G2K149 464
type: UnificationXref
id: A0A0G2K149
db: uniprot

Proprotein convertase subtilisin/kexin type 7
type: ProteinReference
xref: uniprot Q16549 992
organism: Homo sapiens

uniprot E2R5H5 1033
type: UnificationXref
id: E2R5H5
db: uniprot

Trans Golgi network protease furin
type: ProteinReference
xref: PTHR42884:SF1
xref: uniprot Q91000 999
organism: Gallus gallus

uniprot Q90ZE4 557
type: UnificationXref
id: Q90ZE4
db: uniprot

uniprot A0A1D5Q1B1 354
type: UnificationXref
id: A0A1D5Q1B1
db: uniprot

Macrophage metalloelastase
type: ProteinReference
xref: uniprot P34960 637
xref: PTHR10201:SF267
organism: Mus musculus

uniprot P22727 833
type: UnificationXref
id: P22727
db: uniprot

uniprot C3Z299 954
type: UnificationXref
id: C3Z299
db: uniprot

PTHR11937:SF362
type: RelationshipXref
id: PTHR11937:SF362
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF94
xref: uniprot F7HKD3 799
organism: Macaca mulatta

AICD s28 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AICD
stoichiometric coefficient: 1.0

uniprot Q9C5S2 31
type: UnificationXref
id: Q9C5S2
db: uniprot

uniprot A0A1D5R884 662
type: UnificationXref
id: A0A1D5R884
db: uniprot

Presenilin-2
type: ProteinReference
xref: PTHR10202:SF24
xref: uniprot Q90X07 556
organism: Gallus gallus

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 204

uniprot A0NBC9 351
type: UnificationXref
id: A0NBC9
db: uniprot

uniprot F1MHG1 574
type: UnificationXref
id: F1MHG1
db: uniprot

Histone acetyltransferase
type: ProteinReference
xref: uniprot E2RE71 710
xref: PTHR10615:SF183
organism: Canis lupus familiaris

uniprot P50280 640
type: UnificationXref
id: P50280
db: uniprot

Disintegrin and metalloproteinase domain-containing protein 17
type: ProteinReference
xref: uniprot Q9Z0F8 918
xref: PTHR45702:SF6
organism: Mus musculus

uniprot C3XYC5 147
type: UnificationXref
id: C3XYC5
db: uniprot

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF477
xref: uniprot Q6NVA9 303
organism: Xenopus tropicalis

uniprot Q64527 866
type: UnificationXref
id: Q64527
db: uniprot

uniprot P68033 264
type: UnificationXref
id: P68033
db: uniprot

uniprot F7H7V0 932
type: UnificationXref
id: F7H7V0
db: uniprot

Neutrophil collagenase
type: ProteinReference
xref: PTHR10201:SF137
xref: uniprot P22894 632
organism: Homo sapiens

uniprot A0A1D5REM7 888
type: UnificationXref
id: A0A1D5REM7
db: uniprot

uniprot O18784 493
type: UnificationXref
id: O18784
db: uniprot

uniprot Q92993 722
type: UnificationXref
id: Q92993
db: uniprot

Actin
type: ProteinReference
xref: uniprot Q75HX0 311
xref: PTHR11937:SF248
organism: Oryza sativa

Matrix metalloproteinase-14 preproprotein
type: ProteinReference
xref: uniprot F7GFT1 602
xref: PTHR10201:SF24
organism: Macaca mulatta

uniprot P34889 840
type: UnificationXref
id: P34889
db: uniprot

E-cadherin N-terminal fragment
type: ProteinReference
xref: P00165
comment: ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.E-cadherin_br_N-terminal_br_fragment
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: E-cadherin N-terminal fragment Synonym: Synonym not specified Accession: P00165
member entity reference: Cadherin-1
member entity reference: Cadherin-3
member entity reference: Cadherin 3
member entity reference: Uncharacterized protein
member entity reference: CDH1 isoform 1
member entity reference: Cadherin 1, type 1, E-cadherin (epithelial)
member entity reference: CDH3 isoform 2

uniprot F6PG65 55
type: UnificationXref
id: F6PG65
db: uniprot

uniprot Q08DP5 718
type: UnificationXref
id: Q08DP5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HAC1-RIGHT__HAC1-_r39
controller: Ire-1 C-terminal fragment

Frizzled-5
type: ProteinReference
xref: PTHR11309:SF136
xref: uniprot Q9EQD0 423
organism: Mus musculus

72 kDa type IV collagenase
type: ProteinReference
xref: PTHR10201:SF29
xref: uniprot P33434 634
organism: Mus musculus

Collagenase 3
type: ProteinReference
xref: PTHR10201:SF165
xref: uniprot P33435 635
organism: Mus musculus

PTHR24270:SF12
type: RelationshipXref
id: PTHR24270:SF12
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot Q4JLT0 864
organism: Danio rerio

DE-cadherin
type: ProteinReference
xref: PTHR24026:SF108
xref: uniprot Q24298 352
organism: Drosophila melanogaster

Monosiga brevicollis
type: BioSource
xref: ncbitaxon 81824 134

uniprot P60010 244
type: UnificationXref
id: P60010
db: uniprot

uniprot Q38E94 282
type: UnificationXref
id: Q38E94
db: uniprot

uniprot A0A3Q1MU04 521
type: UnificationXref
id: A0A3Q1MU04
db: uniprot