TRP (Transient receptor potential) channel family
Neurogenic locus notch homolog protein 2
Proprotein convertase subtilisin/kexin type 2
ENTITY_REFERENCE_NOTES=Long Name: Nectin 1alpha transmembrane fragment Synonym: Synonym not specified Accession: P00134
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Nectin 1_alpha__br_transmembrane_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: LRP intracellular fragment Synonym: Synonym not specified Accession: P00173
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.LRP_br_intracellular_br_fragment
Disintegrin and metalloproteinase domain-containing protein 17
Low density lipoprotein receptor-related protein 3
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.TCF/LEF
ENTITY_REFERENCE_NOTES=Long Name: T-cell factor/lymphoid enhancer factor Synonym: T-cell-specific transcription factor 1 Accession: P00143
ENTITY_REFERENCE_NOTES=Long Name: LRP transmembrane fragment Synonym: Synonym not specified Accession: P00152
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.LRP_br_transmembrane_br_fragment
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.actin
ENTITY_REFERENCE_NOTES=Long Name: actin Synonym: Synonym not specified Accession: P00114
Short transient receptor potential channel 1
ENTITY_REFERENCE_NOTES=Long Name: Beta-amyloid Synonym: Synonym not specified Accession: P00136
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.A_beta_
ENTITY_REFERENCE_NOTES=Long Name: Nectin 1alpha C-terminal fragment Synonym: Synonym not specified Accession: P00177
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Nectin 1_alpha__br_C-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: amyloid precursor protein Synonym: Synonym not specified Accession: P00127
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.APP
Transient receptor potential cation channel, subfamily C, member 1
Transient receptor potential Ca2+ channel 6A
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.CSL
ENTITY_REFERENCE_NOTES=Long Name: CBF1 Su1 and Lag1 Synonym: Synonym not specified Accession: P00158
Neuroendocrine convertase 2 isoform 1 preproprotein
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Erb-B4_br_N-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Erb-B4 N-terminal fragment Synonym: Synonym not specified Accession: P00148
Recombining binding protein suppressor of hairless
Amyloid precursor binding protein, family B
ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor binding protein, family B Synonym: Rir Accession: P00126
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Fe65
Transient receptor potential cation channel subfamily C member 1
Amyloid-beta A4 precursor protein-binding family B member 3
Proprotein convertase subtilisin/kexin type 6
Afadin, adherens junction formation factor
Recombination signal-binding protein for immunoglobulin kappa J region
Gamma-secretase subunit APH-1B isoform 1
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Presenilin
ENTITY_REFERENCE_NOTES=Long Name: Presenilin Synonym: Synonym not specified Accession: P00129
Low-density lipoprotein receptor-related protein
Short transient receptor potential channel 4
Serine/threonine-protein kinase/endoribonuclease IRE1
ENTITY_REFERENCE_NOTES=Long Name: Anterior pharynx defective-1 Synonym: Synonym not specified Accession: P00170
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Aph-1
Complex (Nicastrin/Aph-1/ Pen-2/Presenilin N-terminal fragment/ Presenilin C-terminal fragment)
Low-density lipoprotein receptor-related protein 6
Recombining binding protein suppressor of hairless-like protein
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Notch_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Notch fragment Synonym: Synonym not specified Accession: P00154
Segment polarity protein dishevelled homolog DVL-3
Transient receptor potential cation channel subfamily C member 3
Carboxy-terminal 99 amino acids of amyloid precursor protein
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.C99
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.NICD
ENTITY_REFERENCE_NOTES=Long Name: Notch intracellular domain Synonym: Synonym not specified Accession: P00122
Transient-receptor-potential-like protein
Transient receptor potential cation channel subfamily C member 7
ENTITY_REFERENCE_NOTES=Long Name: Erb-B4 C-terminal fragment Synonym: Synonym not specified Accession: P00163
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Erb-B4_br_C-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Dishevelled Synonym: Synonym not specified Accession: P00132
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Dsh
Segment polarity protein dishevelled homolog DVL-1
Segment polarity protein dishevelled homolog DVL-2
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.CD44
ENTITY_REFERENCE_NOTES=Long Name: Cell surface glycoprotein 44 Synonym: Synonym not specified Accession: P00145
Aph-1 homolog A, gamma-secretase subunit
Recombination signal binding protein for immunoglobulin kappa J region
Amyloid beta precursor protein binding family B member 1
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.BACE-1_br_pro-domain
ENTITY_REFERENCE_NOTES=Long Name: BACE-1 pro-domain Synonym: Synonym not specified Accession: P00178
Short transient receptor potential channel 6
Prolow-density lipoprotein receptor-related protein 1
Low-density lipoprotein receptor-related protein 4
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Ire-1_br_N-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Ire-1 N-terminal fragment Synonym: Synonym not specified Accession: P00110
ENTITY_REFERENCE_NOTES=Long Name: Afadin Synonym: Synonym not specified Accession: P00146
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Afadin
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.CD44_br_intracellular_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: CD44 intracellular fragment Synonym: Synonym not specified Accession: P00121
ENTITY_REFERENCE_NOTES=Long Name: beta-catenin Synonym: Synonym not specified Accession: P00156
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC._beta_-catenin
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Ire-1
ENTITY_REFERENCE_NOTES=Long Name: Ire-1 Synonym: Synonym not specified Accession: P00144
Proprotein convertase subtilisin/kexin type 7
ENTITY_REFERENCE_NOTES=Long Name: Nectin 1alpha intracellular fragment Synonym: Synonym not specified Accession: P00159
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Nectin 1_alpha__br_intracellular_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: gamma-catenin Synonym: Synonym not specified Accession: P00153
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC._gamma_catenin
ENTITY_REFERENCE_NOTES=Long Name: LRP N-terminal fragment Synonym: Synonym not specified Accession: P00169
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.LRP_br_N-terminal_br_fragment
Endoplasmic reticulum to nucleus signaling 2
Proprotein convertase subtilisin/kexin type 4
Putative glycogen synthase kinase-3 homolog
Inactive serine/threonine-protein kinase/endoribonuclease IRE1-like
ENTITY_REFERENCE_NOTES=Long Name: E-cadherin intracellular fragment Synonym: Synonym not specified Accession: P00168
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.E-cadherin_br_intracellular_br_fragment
Endoplasmic reticulum to nucleus signaling 1
Amyloid beta precursor protein binding family B member 2
Proprotein convertase subtilisin/kexin type 1
Short transient receptor potential channel 5
Low-density lipoprotein receptor-related protein 5
Transient receptor potential-gamma protein
Furin, paired basic amino acid cleaving enzyme
Transient receptor potential cation channel, subfamily C, member 7b
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.E-cadherin
ENTITY_REFERENCE_NOTES=Long Name: E-cadherin Synonym: Synonym not specified Accession: P00118
Short transient receptor potential channel 3
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Notch_br_transmembrane_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Notch transmembrane fragment Synonym: Synonym not specified Accession: P00135
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Ire-1_br_C-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Ire-1 C-terminal fragment Synonym: Synonym not specified Accession: P00125
Amyloid-beta A4 precursor protein-binding family B member 2
Low-density lipoprotein receptor-related protein 1B
Neurogenic locus notch homolog protein 1
ENTITY_REFERENCE_NOTES=Long Name: CD44 transmembrane fragment Synonym: Synonym not specified Accession: P00167
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.CD44_br_transmembrane_br_fragment
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.CD44_br_C-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: CD44 C-terminal fragment Synonym: Synonym not specified Accession: P00123
ENTITY_REFERENCE_NOTES=Long Name: Notch Synonym: Synonym not specified Accession: P00176
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Notch
Short transient receptor potential channel 2
ENTITY_REFERENCE_NOTES=Long Name: Erb-B4 transmembrane fragment Synonym: Synonym not specified Accession: P00113
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Erb-B4_br_transmembrane_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Low-density lipoprotein receptor-related protein Synonym: Synonym not specified Accession: P00150
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.LRP
Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_a
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.TACE
ENTITY_REFERENCE_NOTES=Long Name: TNF-alpha converting enzyme Synonym: ADAM17,alpha-secretase Accession: P00147
Serine/threonine-protein kinase/endoribonuclease IRE2
Neurogenic locus notch homolog protein 4
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Notch_br_extracellular_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Frizzled Synonym: Synonym not specified Accession: P00119
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.RECEPTOR.Frizzled
MODEL_NOTES=Panther Pathway: P00004 The presenilin gamma-secretase complex (consisting of presenilin, nicastrin, Aph-1 and Pen-2) has been demonstrated to cleave several single-transmembrane proteins within the membrane domain, including the amyloid precursor protein, Notch, ErbB4, E-cadherin, Nectin-1alpha, and CD44. This cleavage only occurs sequentially after an inital cleavage on the extracellular side of the transmembrane domain by an alternate enzyme. Cleavage of APP by gamma-secretase after beta-secretase cleavage yields Abeta, the backbone of senile plaques in Alzheimer's disease, and an intracellular fragment capable of nuclear translocation and subsequent effects on gene transcription. Similarly, presenilin-mediated cleavage of Notch and ErbB4 yield intracellular fragments capable of signal transduction. Medline=12142279 Medline=12834808 Medline=14598312 PMID: 12142279 PMID: 12834808 PMID: 14598312
Low-density lipoprotein receptor-related protein 3
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Pen-2
ENTITY_REFERENCE_NOTES=Long Name: Presenilin enhancer 2 Synonym: Synonym not specified Accession: P00149
Transient receptor potential cation channel subfamily C member 6
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Nicastrin
ENTITY_REFERENCE_NOTES=Long Name: Nicastrin Synonym: Synonym not specified Accession: P00115
Short transient receptor potential channel 7
Complex (LRP intracellular fragment/Fe65)
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.E-cadherin_br_transmembrane_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: E-cadherin transmembrane fragment Synonym: Synonym not specified Accession: P00139
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Nectin 1_alpha__br_N-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Nectin 1alpha N-terminal fragment Synonym: Synonym not specified Accession: P00164
Complex (Nectin 1alpha/Afadin/ alphacatenin/actin/ beta-catenin/gammacatenin/ E-cadherin)
ENTITY_REFERENCE_NOTES=Long Name: Furin Synonym: Synonym not specified Accession: P00157
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Furin
ENTITY_REFERENCE_NOTES=Long Name: HIV-1 Tat interactive protein, 60kDa Synonym: HTATIP1,PLIP,TIP,TIP60,cPLA2 Accession: P00137
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Tip60
Amyloid-beta A4 precursor protein-binding family B member 1
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Nectin 1_alpha_
Transient receptor potential cation channel, subfamily C, member 7
Endoplasmic reticulum to nucleus-signaling 1
Amyloid beta precursor protein binding family B member 3
Neuroendocrine convertase 1 isoform 1 preproprotein
Glycogen synthase kinase-3 beta isoform 1
Neurogenic locus notch homolog protein 3
Beta-site amyloid precursor protein-cleaving enzyme
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.BACE-1
ENTITY_REFERENCE_NOTES=Long Name: Beta-amyloid cleavage enzyme Synonym: Asp2,memapsin-2 Accession: P00172
Wingless-type MMTV integration site family member
ENTITY_REFERENCE_NOTES=Long Name: Wingless-type protein Synonym: INT1L1,IRP Accession: P00142
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Wnt
Serine/threonine-protein kinase RIM11/MSD1
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.CD44_br_N-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: CD44 N-terminal fragment Synonym: Synonym not specified Accession: P00174
Catenin (Cadherin-associated protein), beta 1, 88kDa
Complex (Notch N-terminal fragment/Notch extracellular fragment)
Cadherin 1, type 1, E-cadherin (epithelial)
Recombination signal-binding protein for immunoglobulin kappa J region-like
Complex (E-cadherin/beta-catenin/ gammacatenin/alphacatenin/ actin)
Low-density lipoprotein receptor-related protein 2
Amyloid precursor protein intracellular domain
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.AICD
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.E-cadherin_br_C-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: E-cadherin C-terminal fragment Synonym: Synonym not specified Accession: P00117
V-erb-a erythroblastic leukemia viral oncogene homolog 4
ENTITY_REFERENCE_NOTES=Long Name: V-erb-a erythroblastic leukemia viral oncogene homolog 4 Synonym: HER4 Accession: P00128
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Erb-B4
Transient receptor potential cation channel, subfamily C, member 5
ENTITY_REFERENCE_NOTES=Long Name: Membrane metalloprotease Synonym: Synonym not specified Accession: P00141
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Membrane_br_metalloprotease
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Pro-BACE-1
ENTITY_REFERENCE_NOTES=Long Name: Pro-BACE-1 Synonym: Synonym not specified Accession: P00162
Transient receptor potential cation channel subfamily C member 4
ENTITY_REFERENCE_NOTES=Long Name: Notch N-terminal fragment Synonym: Synonym not specified Accession: P00171
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Notch_br_N-terminal_br_fragment
Proprotein convertase subtilisin/kexin type 5
free text Fang,Y.,Kitchell,B.E.,Paria,B.andBalkin,R.
Serine/threonine-protein kinase/endoribonuclease IRE1a
Endoplasmic reticulum (ER) to nucleus signalling 2 (Predicted)
ENTITY_REFERENCE_NOTES=Long Name: Glycogen synthase kinase 3beta Synonym: Synonym not specified Accession: P00175
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.GSK-3_beta_
Amyloid precursor protein beta-ectodomain
ENTITY_REFERENCE_NOTES=Long Name: Amyloid precursor protein beta-ectodomain Synonym: Synonym not specified Accession: P00151
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.APP_beta_
ENTITY_REFERENCE_NOTES=Long Name: Matrix metalloprotease Synonym: Synonym not specified Accession: P00130
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.Matrix_br_metalloprotease
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.ION_CHANNEL.Capacitative_br_calcium_br_channels
ENTITY_REFERENCE_NOTES=Long Name: Capacitative calcium channels Synonym: Synonym not specified Accession: P00124
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Presenilin_br_N-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Presenilin N-terminal fragment Synonym: Synonym not specified Accession: P00140
Transient receptor potential cation channel subfamily C member 1 isoform alpha
ENTITY_REFERENCE_NOTES=Long Name: LRP C-terminal fragment Synonym: Synonym not specified Accession: P00112
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.LRP_br_C-terminal_br_fragment
Complex (Notch N-terminal fragment/Notch C-terminal fragment)
ENTITY_REFERENCE_NOTES=Long Name: Presenilin C-terminal fragment Synonym: Synonym not specified Accession: P00155
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Presenilin_br_C-terminal_br_fragment
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.GENERIC.HAC1
ENTITY_REFERENCE_NOTES=Long Name: Tripartite motif-containing protein 3 Synonym: BERP,RNF22,RNF97 Accession: P00131
Serine/threonine-protein kinase/endoribonuclease IRE1b
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.Notch_br_C-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: Notch C-terminal fragment Synonym: Synonym not specified Accession: P00120
Matrix metallopeptidase 13 (collagenase 3)-like
Matrix metalloproteinase-14 preproprotein
ENTITY_REFERENCE_ID_DESC=Alzheimer disease-presenilin pathway.PROTEIN.TRUNCATED.E-cadherin_br_N-terminal_br_fragment
ENTITY_REFERENCE_NOTES=Long Name: E-cadherin N-terminal fragment Synonym: Synonym not specified Accession: P00165