STATE_TRANSITION_LEFT__N_arachidonoyl_PE-RIGHT__anandamide-_re2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 3
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 2
left: N-arachidonoyl PE
interaction type: STATE_TRANSITION
right: anandamide

PARTICIPANT STOICHIOMETRY re2 2
type: Stoichiometry
physical entity: N-arachidonoyl PE
stoichiometric coefficient: 1.0

anandamide
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re2 3
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

N-acyl transferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__N_arachidonoyl_PE-RIGHT__anandamide-_re2
controller: Phospholipase D

PANTHER Pathway P05727 1
type: UnificationXref
id: P05727
db: PANTHER Pathway

N-arachidonoyl PE
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

phosphatidylethanolamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phospholipase D
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re1 4
type: Stoichiometry
physical entity: phosphatidylethanolamine
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphatidylethanolamine-RIGHT__N_arachidonoyl_PE-_re1
controller: N-acyl transferase

PARTICIPANT STOICHIOMETRY re1 5
type: Stoichiometry
physical entity: N-arachidonoyl PE
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

STATE_TRANSITION_LEFT__phosphatidylethanolamine-RIGHT__N_arachidonoyl_PE-_re1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 4
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 5
left: phosphatidylethanolamine
interaction type: STATE_TRANSITION
right: N-arachidonoyl PE

Anandamide_biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__phosphatidylethanolamine-RIGHT__N_arachidonoyl_PE-_re1
pathway component: STATE_TRANSITION_LEFT__N_arachidonoyl_PE-RIGHT__anandamide-_re2
xref: PANTHER Pathway P05727 1
comment: MODEL_NOTES=Anandamide is an endocannabinoid. After it is released to the extracellular space from postsynaptic terminal, it binds to the cannabinoid receptor on the presynaptic terminal (see Endogenous cannabinoid signaling pathway). Anandamide is also transported via carrier-mediated uptake into nerve endings and glia. The nature of the carrier or transporter has not been characterized. It is believed to be through a selective process if facilitated diffusion. It is believed that anandamide can be produced via hydrolysis of the phospholipid precursor N-arachidonoyl phosphatidylethanolamine (PE), catalyzed by a phospholipase D-type activity. Medline=16938887 Medline=12843414