ncbitaxon 9598 8
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot O08914 12
type: UnificationXref
id: O08914
db: uniprot

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

arachidonic acid
type: SmallMolecule
cellular location: intracellular
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TRANSPORT
type: RelationshipTypeVocabulary

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 8

anandamide
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TRANSPORT
type: InteractionVocabulary

DISSOCIATION
type: InteractionVocabulary

Fatty-acid amide hydrolase 1
type: ProteinReference
xref: uniprot P97612 14
organism: Rattus norvegicus

uniprot O00519 9
type: UnificationXref
id: O00519
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 4

ncbitaxon 9606 10
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot H2PYY9 7
type: UnificationXref
id: H2PYY9
db: uniprot

uniprot F7HMW4 3
type: UnificationXref
id: F7HMW4
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 13

intracellular
type: CellularLocationVocabulary
xref: GO GO:0005622 2

FAAH isoform 1
type: ProteinReference
xref: PTHR45847:SF3
xref: uniprot H2PYY9 7
organism: Pan troglodytes

DISSOCIATION_LEFT__anandamide-RIGHT__ethanolamine-_arachidonic_acid-_re2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 17
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 18
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 19
left: anandamide
interaction type: DISSOCIATION
right: ethanolamine
right: arachidonic acid

PANTHER Pathway P05728 1
type: UnificationXref
id: P05728
db: PANTHER Pathway

PTHR45847:SF3
type: RelationshipXref
id: PTHR45847:SF3
db: PANTHER Family
relationship type: By Homology

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 10

ncbitaxon 10090 13
type: UnificationXref
id: 10090
db: ncbitaxon

ncbitaxon 10116 15
type: UnificationXref
id: 10116
db: ncbitaxon

By Homology
type: RelationshipTypeVocabulary

ethanolamine
type: SmallMolecule
cellular location: intracellular
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

uniprot P97612 14
type: UnificationXref
id: P97612
db: uniprot

PARTICIPANT STOICHIOMETRY re2 19
type: Stoichiometry
physical entity: arachidonic acid
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 18
type: Stoichiometry
physical entity: ethanolamine
stoichiometric coefficient: 1.0

?
type: PhysicalEntity
cellular location: intracellular
comment: SPECIES_TYPE=UNKNOWN

TRANSPORT_LEFT__anandamide-RIGHT__anandamide-_re1
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 20
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 21
left: anandamide
interaction type: TRANSPORT
right: anandamide

DISSOCIATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re1 20
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 21
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

ncbitaxon 9544 4
type: UnificationXref
id: 9544
db: ncbitaxon

P05741
type: UnificationXref
id: P05741
db: PANTHER Pathway Component

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 15

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__anandamide-RIGHT__ethanolamine-_arachidonic_acid-_re2
controller: FAAH

anandamide
type: SmallMolecule
cellular location: intracellular
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Fatty-acid amide hydrolase 1
type: ProteinReference
xref: uniprot O00519 9
xref: PTHR45847:SF3
organism: Homo sapiens

Fatty-acid amide hydrolase 1
type: ProteinReference
xref: uniprot O08914 12
organism: Mus musculus

Fatty-acid amide hydrolase 1
type: ProteinReference
xref: PTHR45847:SF3
xref: uniprot F7HMW4 3
organism: Macaca mulatta

ACTIVE 16
type: EntityFeature
comment: Active state

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

FAAH
type: ProteinReference
xref: P05741
standard name: Fatty acid amide hydrolase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Anandamide_degradation.PROTEIN.GENERIC.FAAH
comment: ENTITY_REFERENCE_NOTES=Long Name: Fatty acid amide hydrolase Synonym: Synonym not specified Accession: P05741
member entity reference: Fatty-acid amide hydrolase 1
member entity reference: FAAH isoform 1

PARTICIPANT STOICHIOMETRY re2 17
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

IDA
type: EvidenceCodeVocabulary

FAAH
type: Protein
entity reference: FAAH
feature: ACTIVE 16
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

GO GO:0005622 2
type: UnificationXref
id: GO:0005622
db: GO

Anandamide_degradation
type: Pathway
pathway component: TRANSPORT_LEFT__anandamide-RIGHT__anandamide-_re1
pathway component: DISSOCIATION_LEFT__anandamide-RIGHT__ethanolamine-_arachidonic_acid-_re2
xref: PANTHER Pathway P05728 1
comment: MODEL_NOTES=Anandamide is an endocannabinoid. After it is released to the extracellular space from postsynaptic terminal, it binds to the cannabinoid receptor on the presynaptic terminal (see Endogenous cannabinoid signaling pathway). Anandamide is also transported via carrier-mediated uptake into nerve endings and glia. The nature of the carrier or transporter has not been characterized. It is believed to be through a selective process if facilitated diffusion. After anandamide is internalized in nerve endings or glia, it is degraded by fatty acid amide hydrolase (FAAH) into arachidonic acid and ethanolamine.

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__anandamide-RIGHT__anandamide-_re1
control type: ACTIVATION
controller: ?