ncbitaxon 9031 24
type: UnificationXref
id: 9031
db: ncbitaxon

NADP+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P35610 42
type: UnificationXref
id: P35610
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__17alpha_hydroxy_progesterone-RIGHT__17alpha_hydroxy_prognenolone-_NADP_PLUS_-_re12
controller: Steroid Delta-isomerase

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

2-Methyl heptanone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

17alpha-hydroxy-progesterone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Testosterone-RIGHT__NADP_PLUS_-_3beta_17beta_Dihydroxy_5_androstene-_re24
controller: 3beta-hydroxy-Delta5-steroid dehydrogenase

Sterylsulfatase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q62904 20
type: UnificationXref
id: Q62904
db: uniprot

Cholesterol acyltransferase
type: Protein
entity reference: Cholesterol acyltransferase
comment: SPECIES_TYPE=PROTEIN

O-acyltransferase
type: ProteinReference
xref: uniprot F7AU50 33
xref: PTHR10408:SF6
organism: Macaca mulatta

ncbitaxon 9615 31
type: UnificationXref
id: 9615
db: ncbitaxon

17-beta-hydroxysteroid dehydrogenase type 6
type: ProteinReference
xref: uniprot O14756 6
organism: Homo sapiens

Mus musculus
type: BioSource
xref: ncbitaxon 10090 11

uniprot P51657 16
type: UnificationXref
id: P51657
db: uniprot

PARTICIPANT STOICHIOMETRY re28 179
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

uniprot O75908 37
type: UnificationXref
id: O75908
db: uniprot

STATE_TRANSITION_LEFT__Estradiol_17beta-RIGHT__NADPH_PLUS_H_PLUS_-_Estrone-_re33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 70
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 68
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 69
left: Estradiol-17beta
interaction type: STATE_TRANSITION
right: Estrone
right: NADPH+H+

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Pregnenolone-RIGHT__17alpha_hydroxy_prognenolone-_NADP_PLUS_-_H2O-_re8
controller: Steroid 17alpha-monooxygenase

Estradiol-17beta
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

DISSOCIATION_LEFT__7alpha_20alpha_dihydroxy_cholesterol-RIGHT__2_Methyl_heptanone-_Dehydroepiandro_sterone-_re15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 147
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 145
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 146
left: 7alpha/20alpha-dihydroxy-cholesterol
interaction type: DISSOCIATION
right: Dehydroepiandro-sterone
right: 2-Methyl heptanone

PARTICIPANT STOICHIOMETRY re14 157
type: Stoichiometry
physical entity: 4-Androstene-3/17-dione
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_17alpha_hydroxy_prognenolone-_O2-RIGHT__NADP_PLUS_-_H2O-_Dehydroepiandro_sterone-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 161
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 159
left: O2
left: NADPH+H+
left: 17alpha-hydroxy-prognenolone
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: Dehydroepiandro-sterone

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_19_hydroxy_testosterone-RIGHT__NADP_PLUS_-_H2O-_Estradiol_17beta-_re31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 82
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 78
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 80
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 77
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 79
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 81
left: O2
left: NADPH+H+
left: 19-hydroxy-testosterone
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: Estradiol-17beta

PARTICIPANT STOICHIOMETRY re14 156
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 182
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 183
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 184
type: Stoichiometry
physical entity: 19-hydroxy-testosterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 180
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_16alpha_hydroxyestrone-RIGHT__NADP_PLUS_-_Estriol-_re30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 85
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 84
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 83
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 86
left: NADPH+H+
left: 16alpha-hydroxyestrone
interaction type: STATE_TRANSITION
right: NADP+
right: Estriol

PARTICIPANT STOICHIOMETRY re28 181
type: Stoichiometry
physical entity: Testosterone
stoichiometric coefficient: 1.0

PTHR10408:SF6
type: RelationshipXref
id: PTHR10408:SF6
db: PANTHER Family
relationship type: By Homology

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 41

PARTICIPANT STOICHIOMETRY re11 168
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 169
type: Stoichiometry
physical entity: 17alpha-hydroxy-progesterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 167
type: Stoichiometry
physical entity: 17alpha-hydroxy-prognenolone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 152
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

By Homology
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re14 153
type: Stoichiometry
physical entity: 17alpha-hydroxy-progesterone
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_H2O-_19_hydroxyandrost_4_ene_3_17_dione-_re29
controller: Aromatase

PARTICIPANT STOICHIOMETRY re14 154
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 155
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

Pregnenolone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re6 101
type: Stoichiometry
physical entity: Pregnenolone
stoichiometric coefficient: 1.0

uniprot P14061 12
type: UnificationXref
id: P14061
db: uniprot

Steroid 19-hydroxylase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re7 100
type: Stoichiometry
physical entity: 7alpha/20alpha-dihydroxy-cholesterol
stoichiometric coefficient: 1.0

Cholesterol monooxygenase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Acyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

3beta-Hydroxysteroid dehydrogenase
type: ProteinReference
xref: P02833
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Androgen/estrogene/progesterone biosynthesis.PROTEIN.GENERIC.3_beta__minus_Hydroxysteroid_br_dehydrogenase
comment: ENTITY_REFERENCE_NOTES=Long Name: 3beta-Hydroxysteroid dehydrogenase Synonym: Synonym not specified Accession: P02833
member entity reference: NADPH-dependent 3-keto-steroid reductase Hsd3b4
member entity reference: 3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase type 2
member entity reference: 3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase type 3
member entity reference: 3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase
member entity reference: 3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase type 6
member entity reference: NADPH-dependent 3-keto-steroid reductase Hsd3b5

uniprot A0A1D5RKB3 2
type: UnificationXref
id: A0A1D5RKB3
db: uniprot

Dehydroepiandro-sterone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 5

O-acyltransferase
type: ProteinReference
xref: PTHR10408:SF10
xref: uniprot F6RU63 32
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Progesterone-RIGHT__NADP_PLUS_-_Pregnenolone-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 170
left: Progesterone
interaction type: STATE_TRANSITION
right: NADP+
right: Pregnenolone

PARTICIPANT STOICHIOMETRY re29 173
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

PTHR10366:SF364
type: RelationshipXref
id: PTHR10366:SF364
db: PANTHER Family
relationship type: By Homology

Aromatase
type: Protein
entity reference: Aromatase
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_Dehydroepiandro_sterone-_re22
controller: Steroid Delta-isomerase

Estradiol 17-beta-dehydrogenase 2
type: ProteinReference
xref: uniprot P37059 14
organism: Homo sapiens

Testosterone 17-beta-dehydrogenase 3
type: ProteinReference
xref: uniprot P37058 13
organism: Homo sapiens

19-hydroxy-testosterone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_Progesterone-_O2-RIGHT__17alpha_hydroxy_progesterone-_NADP_PLUS_-_H2O-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 90
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 92
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 89
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 91
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 88
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 87
left: O2
left: NADPH+H+
left: Progesterone
interaction type: STATE_TRANSITION
right: 17alpha-hydroxy-progesterone
right: H2O
right: NADP+

Sterol O-acyltransferase 1
type: ProteinReference
xref: PTHR10408:SF6
xref: uniprot P35610 42
organism: Homo sapiens

Estriol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

16alpha-hydroxyestrone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Sterol O-acyltransferase 1
type: ProteinReference
xref: PTHR10408:SF6
xref: uniprot O70536 35
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Cholesterol-RIGHT__NADP_PLUS_-_22beta_hydroxycholesterol-_H2O-_re3
controller: Cholesterol monooxygenase

STATE_TRANSITION_LEFT__Pregnenolone-RIGHT__NADPH_PLUS_H_PLUS_-_Progesterone-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 101
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 103
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 102
left: Pregnenolone
interaction type: STATE_TRANSITION
right: NADPH+H+
right: Progesterone

PARTICIPANT STOICHIOMETRY re15 146
type: Stoichiometry
physical entity: 2-Methyl heptanone
stoichiometric coefficient: 1.0

uniprot O88736 10
type: UnificationXref
id: O88736
db: uniprot

uniprot P28649 28
type: UnificationXref
id: P28649
db: uniprot

PARTICIPANT STOICHIOMETRY re15 147
type: Stoichiometry
physical entity: Dehydroepiandro-sterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 145
type: Stoichiometry
physical entity: 7alpha/20alpha-dihydroxy-cholesterol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 132
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 133
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Cholesterol_ester-_H2O-RIGHT__fatty_acid-_Cholesterol-_re1
controller: Cholesterol esterase

PARTICIPANT STOICHIOMETRY re3 131
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 136
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot O14756 6
type: UnificationXref
id: O14756
db: uniprot

PARTICIPANT STOICHIOMETRY re3 134
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re8 98
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 135
type: Stoichiometry
physical entity: 22beta-hydroxycholesterol
stoichiometric coefficient: 1.0

uniprot P14893 53
type: UnificationXref
id: P14893
db: uniprot

PARTICIPANT STOICHIOMETRY re8 96
type: Stoichiometry
physical entity: 17alpha-hydroxy-prognenolone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re8 97
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

uniprot Q61694 57
type: UnificationXref
id: Q61694
db: uniprot

PARTICIPANT STOICHIOMETRY re8 94
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re8 95
type: Stoichiometry
physical entity: Pregnenolone
stoichiometric coefficient: 1.0

O-acyltransferase
type: ProteinReference
xref: PTHR10408:SF6
xref: uniprot A0A2I3SP88 29
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re8 93
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

ncbitaxon 9606 7
type: UnificationXref
id: 9606
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re1 148
type: Stoichiometry
physical entity: Cholesterol ester
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 149
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_Testosterone-_re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 107
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 104
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 105
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 106
left: NADPH+H+
left: 4-Androstene-3/17-dione
interaction type: STATE_TRANSITION
right: NADP+
right: Testosterone

PARTICIPANT STOICHIOMETRY re10 170
type: Stoichiometry
physical entity: Progesterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 171
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 172
type: Stoichiometry
physical entity: Pregnenolone
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pregnenolone-RIGHT__NADPH_PLUS_H_PLUS_-_Progesterone-_re6
controller: Steroid Delta-isomerase

Steroid 16alpha-hydroxylase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot P26149 55
type: UnificationXref
id: P26149
db: uniprot

ncbitaxon 9598 5
type: UnificationXref
id: 9598
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Dehydroepiandro_sterone-RIGHT__NADPH_PLUS_H_PLUS_-_4_Androstene_3_17_dione-_re21
controller: Steroid Delta-isomerase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_17alpha_hydroxy_prognenolone-_O2-RIGHT__NADP_PLUS_-_H2O-_Dehydroepiandro_sterone-_re13
controller: Hydroxyprogesterone aldolase

Bos taurus
type: BioSource
xref: ncbitaxon 9913 54

PTHR10408:SF10
type: RelationshipXref
id: PTHR10408:SF10
db: PANTHER Family
relationship type: By Homology

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 3

Steroid Delta-isomerase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re29 178
type: Stoichiometry
physical entity: 19-hydroxyandrost-4-ene-3/17-dione
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 175
type: Stoichiometry
physical entity: 4-Androstene-3/17-dione
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 174
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 177
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 176
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PTHR10366:SF297
type: RelationshipXref
id: PTHR10366:SF297
db: PANTHER Family
relationship type: By Homology

Testosterone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P02833
type: UnificationXref
id: P02833
db: PANTHER Pathway Component

Sterol O-acyltransferase 2
type: ProteinReference
xref: PTHR10408:SF10
xref: uniprot O88908 38
organism: Mus musculus

O2
type: SmallMolecule
comment: SPECIES_TYPE=ION

DISSOCIATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re19 104
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 105
type: Stoichiometry
physical entity: 4-Androstene-3/17-dione
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 106
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 107
type: Stoichiometry
physical entity: Testosterone
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Estradiol_17beta-RIGHT__NADPH_PLUS_H_PLUS_-_Estrone-_re33
controller: 3beta-Hydroxysteroid dehydrogenase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pregnenolone-RIGHT__NADPH_PLUS_H_PLUS_-_Progesterone-_re6
controller: 3beta-hydroxy-Delta5-steroid dehydrogenase

PARTICIPANT STOICHIOMETRY re13 161
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

uniprot P51658 17
type: UnificationXref
id: P51658
db: uniprot

PARTICIPANT STOICHIOMETRY re13 160
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

P02828
type: UnificationXref
id: P02828
db: PANTHER Pathway Component

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 31

PARTICIPANT STOICHIOMETRY re13 163
type: Stoichiometry
physical entity: Dehydroepiandro-sterone
stoichiometric coefficient: 1.0

P02829
type: UnificationXref
id: P02829
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re13 162
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__17alpha_hydroxy_progesterone-RIGHT__17alpha_hydroxy_prognenolone-_NADP_PLUS_-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 166
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 165
left: 17alpha-hydroxy-progesterone
interaction type: STATE_TRANSITION
right: NADP+
right: 17alpha-hydroxy-prognenolone

P02826
type: UnificationXref
id: P02826
db: PANTHER Pathway Component

Lysosomal acid lipase/cholesteryl ester hydrolase
type: ProteinReference
xref: uniprot Q64194 49
xref: PTHR11005:SF26
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_22beta_hydroxycholesterol-RIGHT__20alpha_22beta_dihydroxycholesterol-_NADP_PLUS_-_H2O-_re4
controller: Cholesterol monooxygenase

P02830
type: UnificationXref
id: P02830
db: PANTHER Pathway Component

uniprot Q7TQM4 45
type: UnificationXref
id: Q7TQM4
db: uniprot

uniprot P37059 14
type: UnificationXref
id: P37059
db: uniprot

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Dehydroepiandro_sterone-RIGHT__NADP_PLUS_-_16alpha_hydroxydehydro_epiandrosterone-_H2O-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 130
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 126
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 129
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 125
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 128
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 127
left: O2
left: NADPH+H+
left: Dehydroepiandro-sterone
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: 16alpha-hydroxydehydro-epiandrosterone

STATE_TRANSITION_LEFT__3beta_17beta_Dihydroxy_5_androstene-RIGHT__NADPH_PLUS_H_PLUS_-_Testosterone-_re23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 190
left: 3beta/17beta-Dihydroxy-5-androstene
interaction type: STATE_TRANSITION
right: Testosterone
right: NADPH+H+

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 24

PARTICIPANT STOICHIOMETRY re13 158
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 159
type: Stoichiometry
physical entity: 17alpha-hydroxy-prognenolone
stoichiometric coefficient: 1.0

uniprot O54753 8
type: UnificationXref
id: O54753
db: uniprot

PARTICIPANT STOICHIOMETRY re23 192
type: Stoichiometry
physical entity: Testosterone
stoichiometric coefficient: 1.0

Lysosomal acid lipase/cholesteryl ester hydrolase
type: ProteinReference
xref: PTHR11005:SF26
xref: uniprot P38571 48
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re23 190
type: Stoichiometry
physical entity: 3beta/17beta-Dihydroxy-5-androstene
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 191
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

Estradiol 17beta-dehydrogenase
type: ProteinReference
xref: P02826
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Androgen/estrogene/progesterone biosynthesis.PROTEIN.GENERIC.Estradiol_space_17_beta__minus_dehydrogenase
comment: ENTITY_REFERENCE_NOTES=Long Name: Estradiol 17beta-dehydrogenase Synonym: Synonym not specified Accession: P02826
member entity reference: Estradiol 17-beta-dehydrogenase 2
member entity reference: 17-beta-hydroxysteroid dehydrogenase type 6
member entity reference: Estradiol 17-beta-dehydrogenase 1
member entity reference: 3-keto-steroid reductase
member entity reference: Testosterone 17-beta-dehydrogenase 3
member entity reference: HSD17B3 isoform 2

Progesterone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Pregnenolone-RIGHT__17alpha_hydroxy_prognenolone-_NADP_PLUS_-_H2O-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 94
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 98
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 96
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 97
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 93
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 95
left: Pregnenolone
left: O2
left: NADPH+H+
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: 17alpha-hydroxy-prognenolone

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_H2O-_19_hydroxyandrost_4_ene_3_17_dione-_re29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 174
left: O2
left: NADPH+H+
left: 4-Androstene-3/17-dione
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: 19-hydroxyandrost-4-ene-3/17-dione

3beta/17beta-Dihydroxy-5-androstene
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Dihydroepiandro_sterone_sulfate-_H2O-RIGHT__H2SO4-_Dehydroepiandro_sterone-_re16
controller: Sterylsulfatase

PARTICIPANT STOICHIOMETRY re6 103
type: Stoichiometry
physical entity: Progesterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 102
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

CoA-SH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot P38571 48
type: UnificationXref
id: P38571
db: uniprot

Cholesterol esterase
type: ProteinReference
xref: P02830
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cholesterol esterase Synonym: Cholesterol ester synthase,Triterpenol esterase Accession: P02830
comment: ENTITY_REFERENCE_ID_DESC=Androgen/estrogene/progesterone biosynthesis.PROTEIN.GENERIC.Cholesterol_br_esterase
member entity reference: Lysosomal acid lipase/cholesteryl ester hydrolase
member entity reference: Lipase

ncbitaxon 9544 3
type: UnificationXref
id: 9544
db: ncbitaxon

STATE_TRANSITION_LEFT__Dihydroepiandro_sterone_sulfate-_H2O-RIGHT__H2SO4-_Dehydroepiandro_sterone-_re16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 140
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 139
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 137
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 138
left: H2O
left: Dihydroepiandro-sterone sulfate
interaction type: STATE_TRANSITION
right: H2SO4
right: Dehydroepiandro-sterone

Aromatase
type: ProteinReference
xref: uniprot P19098 23
xref: PTHR24291:SF43
organism: Gallus gallus

uniprot O88908 38
type: UnificationXref
id: O88908
db: uniprot

Aromatase
type: ProteinReference
xref: uniprot P28649 28
organism: Mus musculus

Estradiol 17-beta-dehydrogenase 2
type: ProteinReference
xref: uniprot Q62730 19
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Acyl_CoA-_Cholesterol-RIGHT__Cholesterol_ester-_CoA_SH-_re2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 144
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 143
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 142
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 141
left: Cholesterol
left: Acyl-CoA
interaction type: STATE_TRANSITION
right: CoA-SH
right: Cholesterol ester

uniprot F7EC56 46
type: UnificationXref
id: F7EC56
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_16alpha_hydroxyestrone-RIGHT__NADP_PLUS_-_Estriol-_re30
controller: Estradiol 17beta-dehydrogenase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Acyl_CoA-_Cholesterol-RIGHT__Cholesterol_ester-_CoA_SH-_re2
controller: Cholesterol acyltransferase

HSD17B3 isoform 2
type: ProteinReference
xref: uniprot A0A2I3S9Q4 4
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__17alpha_hydroxy_prognenolone-RIGHT__NADPH_PLUS_H_PLUS_-_17alpha_hydroxy_progesterone-_re11
controller: Steroid Delta-isomerase

uniprot F1PUL0 30
type: UnificationXref
id: F1PUL0
db: uniprot

Aromatase
type: ProteinReference
xref: P02828
comment: ENTITY_REFERENCE_ID_DESC=Androgen/estrogene/progesterone biosynthesis.PROTEIN.GENERIC.Aromatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Aromatase Synonym: Synonym not specified Accession: P02828
member entity reference: Aromatase

ncbitaxon 9913 54
type: UnificationXref
id: 9913
db: ncbitaxon

3-keto-steroid reductase
type: ProteinReference
xref: uniprot P56937 18
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Progesterone-RIGHT__NADP_PLUS_-_Pregnenolone-_re10
controller: Steroid Delta-isomerase

Sterol O-acyltransferase 2
type: ProteinReference
xref: PTHR10408:SF10
xref: uniprot Q7TQM4 45
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_17alpha_hydroxy_progesterone-_O2-RIGHT__NADP_PLUS_-_H2O-_4_Androstene_3_17_dione-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 157
left: 17alpha-hydroxy-progesterone
left: O2
left: NADPH+H+
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: 4-Androstene-3/17-dione

20alpha/22beta dihydroxycholesterol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re16 140
type: Stoichiometry
physical entity: Dehydroepiandro-sterone
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Cholesterol-RIGHT__7alpha_20alpha_dihydroxy_cholesterol-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 100
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 99
left: Cholesterol
interaction type: STATE_TRANSITION
right: 7alpha/20alpha-dihydroxy-cholesterol

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Estrone-RIGHT__NADP_PLUS_-_Estradiol_17beta-_re34
controller: 3beta-Hydroxysteroid dehydrogenase

PARTICIPANT STOICHIOMETRY re16 137
type: Stoichiometry
physical entity: Dihydroepiandro-sterone sulfate
stoichiometric coefficient: 1.0

eco ECO:0000303 39
type: UnificationXref
id: ECO:0000303
db: eco

PARTICIPANT STOICHIOMETRY re16 138
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 139
type: Stoichiometry
physical entity: H2SO4
stoichiometric coefficient: 1.0

Sterol O-acyltransferase 2
type: ProteinReference
xref: PTHR10408:SF10
xref: uniprot O75908 37
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re18 117
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 116
type: Stoichiometry
physical entity: Dehydroepiandro-sterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 118
type: Stoichiometry
physical entity: 3beta/17beta-Dihydroxy-5-androstene
stoichiometric coefficient: 1.0

O-acyltransferase
type: ProteinReference
xref: uniprot O97295 40
organism: Plasmodium falciparum

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Estrone-RIGHT__NADP_PLUS_-_Estradiol_17beta-_re34
controller: Estradiol 17beta-dehydrogenase

PARTICIPANT STOICHIOMETRY re18 115
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

17-beta-hydroxysteroid dehydrogenase type 6
type: ProteinReference
xref: uniprot Q9R092 21
organism: Mus musculus

Lipase
type: ProteinReference
xref: PTHR11005:SF26
xref: uniprot H2Q287 47
organism: Pan troglodytes

3-keto-steroid reductase
type: ProteinReference
xref: uniprot O88736 10
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Testosterone-RIGHT__NADP_PLUS_-_3beta_17beta_Dihydroxy_5_androstene-_re24
controller: Steroid Delta-isomerase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_Dehydroepiandro_sterone-_re22
controller: 3beta-hydroxy-Delta5-steroid dehydrogenase

PANTHER Pathway P02727 1
type: UnificationXref
id: P02727
db: PANTHER Pathway

uniprot O35469 51
type: UnificationXref
id: O35469
db: uniprot

NADPH+H+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

eco ECO:0000353 52
type: UnificationXref
id: ECO:0000353
db: eco

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Testosterone-RIGHT__NADP_PLUS_-_H2O-_19_hydroxy_testosterone-_re28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 184
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 181
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 180
left: Testosterone
left: O2
left: NADPH+H+
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: 19-hydroxy-testosterone

PARTICIPANT STOICHIOMETRY re17 126
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

Lipase
type: ProteinReference
xref: uniprot F7EC56 46
xref: PTHR11005:SF26
organism: Macaca mulatta

Estradiol 17-beta-dehydrogenase 1
type: ProteinReference
xref: uniprot P14061 12
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re17 127
type: Stoichiometry
physical entity: Dehydroepiandro-sterone
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__3beta_17beta_Dihydroxy_5_androstene-RIGHT__NADPH_PLUS_H_PLUS_-_Testosterone-_re23
controller: 3beta-hydroxy-Delta5-steroid dehydrogenase

STATE_TRANSITION_LEFT__4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_Dehydroepiandro_sterone-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 195
left: 4-Androstene-3/17-dione
interaction type: STATE_TRANSITION
right: NADP+
right: Dehydroepiandro-sterone

PARTICIPANT STOICHIOMETRY re17 125
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 52

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 25

3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase type 6
type: ProteinReference
xref: PTHR10366:SF364
xref: uniprot O35469 51
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Testosterone-RIGHT__NADP_PLUS_-_H2O-_19_hydroxy_testosterone-_re28
controller: Steroid 19-hydroxylase

4-Androstene-3/17-dione
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Isocaproic aldehyde
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re17 128
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 129
type: Stoichiometry
physical entity: 16alpha-hydroxydehydro-epiandrosterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 186
type: Stoichiometry
physical entity: 16alpha-hydroxyestrone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 185
type: Stoichiometry
physical entity: 16alpha-hydroxydehydro-epiandrosterone
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Dehydroepiandro_sterone-RIGHT__NADPH_PLUS_H_PLUS_-_4_Androstene_3_17_dione-_re21
controller: 3beta-hydroxy-Delta5-steroid dehydrogenase

PARTICIPANT STOICHIOMETRY re21 198
type: Stoichiometry
physical entity: 4-Androstene-3/17-dione
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 197
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 196
type: Stoichiometry
physical entity: Dehydroepiandro-sterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 130
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__16alpha_hydroxydehydro_epiandrosterone-RIGHT__16alpha_hydroxyestrone-_re25
controller: Aromatase

uniprot Q62730 19
type: UnificationXref
id: Q62730
db: uniprot

Cholesterol acyltransferase
type: ProteinReference
xref: P02829
comment: ENTITY_REFERENCE_ID_DESC=Androgen/estrogene/progesterone biosynthesis.PROTEIN.GENERIC.Cholesterol_br_acyltransferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cholesterol acyltransferase Synonym: ACAT,acyl-CoA:cholesterol acyl transferase Accession: P02829
member entity reference: Sterol O-acyltransferase 2
member entity reference: O-acyltransferase
member entity reference: Sterol O-acyltransferase 1

uniprot P22443 27
type: UnificationXref
id: P22443
db: uniprot

Steroid 17alpha-monooxygenase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re32 72
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 71
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 74
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 73
type: Stoichiometry
physical entity: 19-hydroxyandrost-4-ene-3/17-dione
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 76
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 75
type: Stoichiometry
physical entity: Estrone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 91
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

uniprot H2Q613 34
type: UnificationXref
id: H2Q613
db: uniprot

PARTICIPANT STOICHIOMETRY re9 92
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 90
type: Stoichiometry
physical entity: 17alpha-hydroxy-progesterone
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Estrone-RIGHT__NADP_PLUS_-_H2O-_16alpha_hydroxyestrone-_re35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 63
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 59
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 61
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 64
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 60
participant stoichiometry: PARTICIPANT STOICHIOMETRY re35 62
left: Estrone
left: O2
left: NADPH+H+
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: 16alpha-hydroxyestrone

uniprot Q61263 43
type: UnificationXref
id: Q61263
db: uniprot

PARTICIPANT STOICHIOMETRY re9 88
type: Stoichiometry
physical entity: Progesterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 89
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 69
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

19-hydroxyandrost-4-ene-3/17-dione
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 36329 41
type: UnificationXref
id: 36329
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re33 68
type: Stoichiometry
physical entity: Estradiol-17beta
stoichiometric coefficient: 1.0

eco ECO:0000304 50
type: UnificationXref
id: ECO:0000304
db: eco

STATE_TRANSITION_LEFT__16alpha_hydroxydehydro_epiandrosterone-RIGHT__16alpha_hydroxyestrone-_re25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 186
left: 16alpha-hydroxydehydro-epiandrosterone
interaction type: STATE_TRANSITION
right: 16alpha-hydroxyestrone

uniprot P11511 22
type: UnificationXref
id: P11511
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_Testosterone-_re19
controller: 3beta-Hydroxysteroid dehydrogenase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__17alpha_hydroxy_prognenolone-RIGHT__NADPH_PLUS_H_PLUS_-_17alpha_hydroxy_progesterone-_re11
controller: 3beta-hydroxy-Delta5-steroid dehydrogenase

STATE_TRANSITION_LEFT__17alpha_hydroxy_prognenolone-RIGHT__NADPH_PLUS_H_PLUS_-_17alpha_hydroxy_progesterone-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 167
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 168
left: 17alpha-hydroxy-prognenolone
interaction type: STATE_TRANSITION
right: 17alpha-hydroxy-progesterone
right: NADPH+H+

Hydroxyprogesterone aldolase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re9 87
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

fatty acid
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

DISSOCIATION
type: InteractionVocabulary

Aromatase
type: ProteinReference
xref: uniprot P22443 27
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Progesterone-RIGHT__NADP_PLUS_-_Pregnenolone-_re10
controller: 3beta-hydroxy-Delta5-steroid dehydrogenase

uniprot Q9R092 21
type: UnificationXref
id: Q9R092
db: uniprot

PARTICIPANT STOICHIOMETRY re35 61
type: Stoichiometry
physical entity: Estrone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re35 62
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re35 60
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

Androgen/estrogene/progesterone biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Pregnenolone-RIGHT__NADPH_PLUS_H_PLUS_-_Progesterone-_re6
pathway component: DISSOCIATION_LEFT__7alpha_20alpha_dihydroxy_cholesterol-RIGHT__2_Methyl_heptanone-_Dehydroepiandro_sterone-_re15
pathway component: STATE_TRANSITION_LEFT__17alpha_hydroxy_progesterone-RIGHT__17alpha_hydroxy_prognenolone-_NADP_PLUS_-_re12
pathway component: STATE_TRANSITION_LEFT__Testosterone-RIGHT__NADP_PLUS_-_3beta_17beta_Dihydroxy_5_androstene-_re24
pathway component: STATE_TRANSITION_LEFT__16alpha_hydroxydehydro_epiandrosterone-RIGHT__16alpha_hydroxyestrone-_re25
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Pregnenolone-RIGHT__17alpha_hydroxy_prognenolone-_NADP_PLUS_-_H2O-_re8
pathway component: STATE_TRANSITION_LEFT__Acyl_CoA-_Cholesterol-RIGHT__Cholesterol_ester-_CoA_SH-_re2
pathway component: STATE_TRANSITION_LEFT__Estradiol_17beta-RIGHT__NADPH_PLUS_H_PLUS_-_Estrone-_re33
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_H2O-_19_hydroxyandrost_4_ene_3_17_dione-_re29
pathway component: STATE_TRANSITION_LEFT__4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_Dehydroepiandro_sterone-_re22
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_16alpha_hydroxyestrone-RIGHT__NADP_PLUS_-_Estriol-_re30
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_22beta_hydroxycholesterol-RIGHT__20alpha_22beta_dihydroxycholesterol-_NADP_PLUS_-_H2O-_re4
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_Testosterone-_re19
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_19_hydroxyandrost_4_ene_3_17_dione-RIGHT__NADP_PLUS_-_Estrone-_H2O-_re32
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Estrone-RIGHT__NADP_PLUS_-_H2O-_16alpha_hydroxyestrone-_re35
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_17alpha_hydroxy_progesterone-_O2-RIGHT__NADP_PLUS_-_H2O-_4_Androstene_3_17_dione-_re14
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_17alpha_hydroxy_prognenolone-_O2-RIGHT__NADP_PLUS_-_H2O-_Dehydroepiandro_sterone-_re13
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_19_hydroxy_testosterone-RIGHT__NADP_PLUS_-_H2O-_Estradiol_17beta-_re31
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Testosterone-RIGHT__NADP_PLUS_-_H2O-_19_hydroxy_testosterone-_re28
pathway component: STATE_TRANSITION_LEFT__3beta_17beta_Dihydroxy_5_androstene-RIGHT__NADPH_PLUS_H_PLUS_-_Testosterone-_re23
pathway component: STATE_TRANSITION_LEFT__Dihydroepiandro_sterone_sulfate-_H2O-RIGHT__H2SO4-_Dehydroepiandro_sterone-_re16
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Dehydroepiandro_sterone-RIGHT__NADP_PLUS_-_16alpha_hydroxydehydro_epiandrosterone-_H2O-_re17
pathway component: STATE_TRANSITION_LEFT__Dehydroepiandro_sterone-RIGHT__NADPH_PLUS_H_PLUS_-_4_Androstene_3_17_dione-_re21
pathway component: STATE_TRANSITION_LEFT__Cholesterol_ester-_H2O-RIGHT__fatty_acid-_Cholesterol-_re1
pathway component: STATE_TRANSITION_LEFT__Cholesterol-RIGHT__7alpha_20alpha_dihydroxy_cholesterol-_re7
pathway component: STATE_TRANSITION_LEFT__Estrone-RIGHT__NADP_PLUS_-_Estradiol_17beta-_re34
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Cholesterol-RIGHT__NADP_PLUS_-_22beta_hydroxycholesterol-_H2O-_re3
pathway component: STATE_TRANSITION_LEFT__17alpha_hydroxy_prognenolone-RIGHT__NADPH_PLUS_H_PLUS_-_17alpha_hydroxy_progesterone-_re11
pathway component: STATE_TRANSITION_LEFT__Progesterone-RIGHT__NADP_PLUS_-_Pregnenolone-_re10
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_Progesterone-_O2-RIGHT__17alpha_hydroxy_progesterone-_NADP_PLUS_-_H2O-_re9
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_Dehydroepiandro_sterone-RIGHT__NADP_PLUS_-_3beta_17beta_Dihydroxy_5_androstene-_re18
pathway component: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_20alpha_22beta_dihydroxycholesterol-_O2-RIGHT__NADP_PLUS_-_Pregnenolone-_H2O-_Isocaproic_aldehyde-_re5
xref: PANTHER Pathway P02727 1
comment: MODEL_NOTES=Cholesterol is the origin of multitude of steroids, which are of high importance in metabolic processes. The common synthesis path starts with the partial removal of the cholesterol side chain, yielding the gestagen progesterone. Removal of the remaining side chain leads to androgens, a further aromatozation of ring A yields estrogens. free text=Biochemical Pathways - An atlas of Biochemistry and Molecular Biology - Gerhard Michal

PARTICIPANT STOICHIOMETRY re35 64
type: Stoichiometry
physical entity: 16alpha-hydroxyestrone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re35 63
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 70
type: Stoichiometry
physical entity: Estrone
stoichiometric coefficient: 1.0

17alpha-hydroxy-prognenolone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_Dehydroepiandro_sterone-RIGHT__NADP_PLUS_-_3beta_17beta_Dihydroxy_5_androstene-_re18
controller: 3beta-Hydroxysteroid dehydrogenase

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 7

uniprot P26150 56
type: UnificationXref
id: P26150
db: uniprot

uniprot P51656 15
type: UnificationXref
id: P51656
db: uniprot

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_22beta_hydroxycholesterol-RIGHT__20alpha_22beta_dihydroxycholesterol-_NADP_PLUS_-_H2O-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 123
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 121
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 124
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 120
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 119
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 122
left: 22beta-hydroxycholesterol
left: O2
left: NADPH+H+
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: 20alpha/22beta dihydroxycholesterol

PARTICIPANT STOICHIOMETRY re31 81
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 82
type: Stoichiometry
physical entity: Estradiol-17beta
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_20alpha_22beta_dihydroxycholesterol-_O2-RIGHT__NADP_PLUS_-_Pregnenolone-_H2O-_Isocaproic_aldehyde-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 112
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 109
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 108
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 114
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 113
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 110
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 111
left: 20alpha/22beta dihydroxycholesterol
left: O2
left: NADPH+H+
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: Pregnenolone
right: Isocaproic aldehyde

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Estrone-RIGHT__NADP_PLUS_-_H2O-_16alpha_hydroxyestrone-_re35
controller: Steroid 16alpha-hydroxylase

Testosterone 17-beta-dehydrogenase 3
type: ProteinReference
xref: uniprot A0A1D5RKB3 2
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re1 150
type: Stoichiometry
physical entity: fatty acid
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 151
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re35 59
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

Estradiol 17-beta-dehydrogenase 2
type: ProteinReference
xref: uniprot P51658 17
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re7 99
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

Estradiol 17-beta-dehydrogenase 1
type: ProteinReference
xref: uniprot P51656 15
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re31 80
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

Estradiol 17-beta-dehydrogenase 1
type: ProteinReference
xref: uniprot P51657 16
organism: Rattus norvegicus

3beta-Hydroxysteroid dehydrogenase
type: Protein
entity reference: 3beta-Hydroxysteroid dehydrogenase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re5 114
type: Stoichiometry
physical entity: Isocaproic aldehyde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 110
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 111
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 112
type: Stoichiometry
physical entity: Pregnenolone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 113
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Cholesterol esterase
type: Protein
entity reference: Cholesterol esterase
comment: SPECIES_TYPE=PROTEIN

3-keto-steroid reductase
type: ProteinReference
xref: uniprot Q62904 20
organism: Rattus norvegicus

uniprot P19098 23
type: UnificationXref
id: P19098
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Testosterone-RIGHT__NADP_PLUS_-_H2O-_19_hydroxy_testosterone-_re28
controller: Aromatase

eco ECO:0000250 25
type: UnificationXref
id: ECO:0000250
db: eco

PARTICIPANT STOICHIOMETRY re5 108
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 109
type: Stoichiometry
physical entity: 20alpha/22beta dihydroxycholesterol
stoichiometric coefficient: 1.0

Estrone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Dehydroepiandro_sterone-RIGHT__NADP_PLUS_-_16alpha_hydroxydehydro_epiandrosterone-_H2O-_re17
controller: Steroid 16alpha-hydroxylase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__3beta_17beta_Dihydroxy_5_androstene-RIGHT__NADPH_PLUS_H_PLUS_-_Testosterone-_re23
controller: Steroid Delta-isomerase

uniprot A0A2I3SP88 29
type: UnificationXref
id: A0A2I3SP88
db: uniprot

Sterol O-acyltransferase 1
type: ProteinReference
xref: PTHR10408:SF6
xref: uniprot Q61263 43
organism: Mus musculus

uniprot O70536 35
type: UnificationXref
id: O70536
db: uniprot

IDA
type: EvidenceCodeVocabulary

17-beta-hydroxysteroid dehydrogenase type 6
type: ProteinReference
xref: uniprot O54753 8
organism: Rattus norvegicus

3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase type 3
type: ProteinReference
xref: PTHR10366:SF364
xref: uniprot P26150 56
organism: Mus musculus

ncbitaxon 10090 11
type: UnificationXref
id: 10090
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re31 79
type: Stoichiometry
physical entity: 19-hydroxy-testosterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 78
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

uniprot P56937 18
type: UnificationXref
id: P56937
db: uniprot

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 39

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_19_hydroxyandrost_4_ene_3_17_dione-RIGHT__NADP_PLUS_-_Estrone-_H2O-_re32
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 74
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 76
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 73
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 71
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 75
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 72
left: O2
left: NADPH+H+
left: 19-hydroxyandrost-4-ene-3/17-dione
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: Estrone

PARTICIPANT STOICHIOMETRY re34 65
type: Stoichiometry
physical entity: Estrone
stoichiometric coefficient: 1.0

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 50

PARTICIPANT STOICHIOMETRY re34 66
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re34 67
type: Stoichiometry
physical entity: Estradiol-17beta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 77
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 121
type: Stoichiometry
physical entity: 22beta-hydroxycholesterol
stoichiometric coefficient: 1.0

3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase type 2
type: ProteinReference
xref: uniprot P26149 55
xref: PTHR10366:SF364
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re4 120
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

Steroid 16alpha-hydroxylase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re4 124
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 123
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Estradiol_17beta-RIGHT__NADPH_PLUS_H_PLUS_-_Estrone-_re33
controller: Estradiol 17beta-dehydrogenase

PARTICIPANT STOICHIOMETRY re4 122
type: Stoichiometry
physical entity: 20alpha/22beta dihydroxycholesterol
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_Cholesterol-RIGHT__NADP_PLUS_-_22beta_hydroxycholesterol-_H2O-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 134
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 133
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 131
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 136
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 132
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 135
left: O2
left: NADPH+H+
left: Cholesterol
interaction type: STATE_TRANSITION
right: H2O
right: NADP+
right: 22beta-hydroxycholesterol

PTHR11005:SF26
type: RelationshipXref
id: PTHR11005:SF26
db: PANTHER Family
relationship type: By Homology

Aromatase
type: ProteinReference
xref: uniprot P11511 22
organism: Homo sapiens

3 beta-hydroxysteroid dehydrogenase/Delta 5--4-isomerase
type: ProteinReference
xref: uniprot P14893 53
xref: PTHR10366:SF364
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_Progesterone-_O2-RIGHT__17alpha_hydroxy_progesterone-_NADP_PLUS_-_H2O-_re9
controller: Steroid 17alpha-monooxygenase

PARTICIPANT STOICHIOMETRY re12 166
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 165
type: Stoichiometry
physical entity: 17alpha-hydroxy-prognenolone
stoichiometric coefficient: 1.0

uniprot Q61767 58
type: UnificationXref
id: Q61767
db: uniprot

STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_Dehydroepiandro_sterone-RIGHT__NADP_PLUS_-_3beta_17beta_Dihydroxy_5_androstene-_re18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 115
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 117
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 118
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 116
left: NADPH+H+
left: Dehydroepiandro-sterone
interaction type: STATE_TRANSITION
right: NADP+
right: 3beta/17beta-Dihydroxy-5-androstene

PARTICIPANT STOICHIOMETRY re12 164
type: Stoichiometry
physical entity: 17alpha-hydroxy-progesterone
stoichiometric coefficient: 1.0

uniprot H2Q287 47
type: UnificationXref
id: H2Q287
db: uniprot

NADPH-dependent 3-keto-steroid reductase Hsd3b4
type: ProteinReference
xref: uniprot Q61767 58
xref: PTHR10366:SF297
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re4 119
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 9

16alpha-hydroxydehydro-epiandrosterone
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cholesterol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re2 144
type: Stoichiometry
physical entity: CoA-SH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 142
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 143
type: Stoichiometry
physical entity: Cholesterol ester
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 141
type: Stoichiometry
physical entity: Acyl-CoA
stoichiometric coefficient: 1.0

O-acyltransferase
type: ProteinReference
xref: PTHR10408:SF10
xref: uniprot H2Q613 34
organism: Pan troglodytes

uniprot P37058 13
type: UnificationXref
id: P37058
db: uniprot

uniprot O97295 40
type: UnificationXref
id: O97295
db: uniprot

uniprot A0A2I3S9Q4 4
type: UnificationXref
id: A0A2I3S9Q4
db: uniprot

O-acyltransferase
type: ProteinReference
xref: PTHR10408:SF6
xref: uniprot F1PUL0 30
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re24 188
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 195
type: Stoichiometry
physical entity: Dehydroepiandro-sterone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 189
type: Stoichiometry
physical entity: 3beta/17beta-Dihydroxy-5-androstene
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Estrone-RIGHT__NADP_PLUS_-_Estradiol_17beta-_re34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 65
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 67
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 66
left: Estrone
interaction type: STATE_TRANSITION
right: NADP+
right: Estradiol-17beta

NADPH-dependent 3-keto-steroid reductase Hsd3b5
type: ProteinReference
xref: uniprot Q61694 57
xref: PTHR10366:SF297
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re24 187
type: Stoichiometry
physical entity: Testosterone
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__17alpha_hydroxy_progesterone-RIGHT__17alpha_hydroxy_prognenolone-_NADP_PLUS_-_re12
controller: 3beta-hydroxy-Delta5-steroid dehydrogenase

PARTICIPANT STOICHIOMETRY re22 194
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 193
type: Stoichiometry
physical entity: 4-Androstene-3/17-dione
stoichiometric coefficient: 1.0

PTHR24291:SF43
type: RelationshipXref
id: PTHR24291:SF43
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_19_hydroxy_testosterone-RIGHT__NADP_PLUS_-_H2O-_Estradiol_17beta-_re31
controller: Aromatase

STATE_TRANSITION_LEFT__Dehydroepiandro_sterone-RIGHT__NADPH_PLUS_H_PLUS_-_4_Androstene_3_17_dione-_re21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 197
left: Dehydroepiandro-sterone
interaction type: STATE_TRANSITION
right: NADPH+H+
right: 4-Androstene-3/17-dione

Estradiol 17beta-dehydrogenase
type: Protein
entity reference: Estradiol 17beta-dehydrogenase
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION
type: InteractionVocabulary

7alpha/20alpha-dihydroxy-cholesterol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__Cholesterol_ester-_H2O-RIGHT__fatty_acid-_Cholesterol-_re1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 149
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 148
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 150
left: H2O
left: Cholesterol ester
interaction type: STATE_TRANSITION
right: fatty acid
right: Cholesterol

uniprot F6RU63 32
type: UnificationXref
id: F6RU63
db: uniprot

Cholesterol ester
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_4_Androstene_3_17_dione-RIGHT__NADP_PLUS_-_H2O-_19_hydroxyandrost_4_ene_3_17_dione-_re29
controller: Steroid 19-hydroxylase

uniprot F7AU50 33
type: UnificationXref
id: F7AU50
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_20alpha_22beta_dihydroxycholesterol-_O2-RIGHT__NADP_PLUS_-_Pregnenolone-_H2O-_Isocaproic_aldehyde-_re5
controller: Cholesterol monooxygenase

ncbitaxon 10116 9
type: UnificationXref
id: 10116
db: ncbitaxon

3beta-hydroxy-Delta5-steroid dehydrogenase
type: Protein
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Testosterone-RIGHT__NADP_PLUS_-_3beta_17beta_Dihydroxy_5_androstene-_re24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 188
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 189
left: Testosterone
interaction type: STATE_TRANSITION
right: NADP+
right: 3beta/17beta-Dihydroxy-5-androstene

Dihydroepiandro-sterone sulfate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

IMP
type: EvidenceCodeVocabulary

uniprot Q64194 49
type: UnificationXref
id: Q64194
db: uniprot

PARTICIPANT STOICHIOMETRY re30 83
type: Stoichiometry
physical entity: NADPH+H+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 85
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 84
type: Stoichiometry
physical entity: 16alpha-hydroxyestrone
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 86
type: Stoichiometry
physical entity: Estriol
stoichiometric coefficient: 1.0

H2SO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

22beta-hydroxycholesterol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_O2-_19_hydroxyandrost_4_ene_3_17_dione-RIGHT__NADP_PLUS_-_Estrone-_H2O-_re32
controller: Aromatase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH_PLUS_H_PLUS_-_17alpha_hydroxy_progesterone-_O2-RIGHT__NADP_PLUS_-_H2O-_4_Androstene_3_17_dione-_re14
controller: Hydroxyprogesterone aldolase