Vascular endothelial growth factor receptor 2
type: ProteinReference
xref: uniprot P35968 638
xref: PTHR24416:SF45
organism: Homo sapiens

uniprot Q5RKN6 863
type: UnificationXref
id: Q5RKN6
db: uniprot

uniprot F7BWW9 171
type: UnificationXref
id: F7BWW9
db: uniprot

uniprot J9P1D8 305
type: UnificationXref
id: J9P1D8
db: uniprot

uniprot Q9UP65 1188
type: UnificationXref
id: Q9UP65
db: uniprot

uniprot A8WUL4 300
type: UnificationXref
id: A8WUL4
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6SZ66 906
xref: PTHR10048:SF7
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r176
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r176 1415
participant stoichiometry: PARTICIPANT STOICHIOMETRY r176 1414
left: Ets
interaction type: STATE_TRANSITION
right: Ets

Focal adhesion kinase 1
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot P34152 428
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot A0A452DI16 1074
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r232 1534
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r232 1533
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QK16 186
organism: Macaca mulatta

uniprot F7EX10 468
type: UnificationXref
id: F7EX10
db: uniprot

STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r181
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r181 1388
participant stoichiometry: PARTICIPANT STOICHIOMETRY r181 1387
left: Raf
interaction type: STATE_TRANSITION
right: Raf

Frizzled-2
type: ProteinReference
xref: uniprot Q08464 133
xref: PTHR11309:SF34
organism: Rattus norvegicus

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot H2QIH7 512
organism: Pan troglodytes

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot Q08463 132
organism: Rattus norvegicus

uniprot Q01986 709
type: UnificationXref
id: Q01986
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 17

c-Fos
type: ProteinReference
xref: P00235
standard name: c-Fos Transcription Factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.c-Fos
comment: ENTITY_REFERENCE_NOTES=Long Name: c-Fos Transcription Factor Synonym: Oncogene FOS,v-Fos FBJ Murine Osteosarcoma Viral Oncogene Homolog Accession: P00235
member entity reference: Proto-oncogene c-Fos
member entity reference: V-fos FBJ murine osteosarcoma viral oncogene homolog
member entity reference: Fos proto-oncogene, AP-1 transcription factor subunit
member entity reference: FBJ murine osteosarcoma viral oncogene homolog
member entity reference: Uncharacterized protein
member entity reference: C-fos

uniprot E7EXT6 656
type: UnificationXref
id: E7EXT6
db: uniprot

uniprot D3ZFJ0 890
type: UnificationXref
id: D3ZFJ0
db: uniprot

PARTICIPANT STOICHIOMETRY r225 1342
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r225 1343
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 284
organism: Canis lupus familiaris

HETERODIMER_ASSOCIATION_LEFT__PDGF-_PDGFR-RIGHT__Complex__PDGFR_PDGF_-_r237
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r237 1524
participant stoichiometry: PARTICIPANT STOICHIOMETRY r237 1523
participant stoichiometry: PARTICIPANT STOICHIOMETRY r237 1522
left: PDGFR
left: PDGF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PDGFR/PDGF)

HIF-1
type: ProteinReference
xref: P00214
standard name: Hypoxia Inducible Factor-1
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.HIF-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Hypoxia Inducible Factor-1 Synonym: MOP1,Member of PAS Superfamily 1 Accession: P00214
member entity reference: Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)
member entity reference: Hypoxia-inducible factor 1-alpha
member entity reference: Hypoxia inducible factor 1 subunit alpha
member entity reference: Uncharacterized protein
member entity reference: HIF1A isoform 7

Neurogenic locus notch homolog protein 2
type: ProteinReference
xref: uniprot Q04721 1265
xref: PTHR45836:SF15
organism: Homo sapiens

uniprot Q54PQ4 179
type: UnificationXref
id: Q54PQ4
db: uniprot

Alpha-crystallin A chain
type: ProteinReference
xref: uniprot P24622 826
organism: Mus musculus

uniprot Q60838 268
type: UnificationXref
id: Q60838
db: uniprot

uniprot F6WRD7 687
type: UnificationXref
id: F6WRD7
db: uniprot

uniprot P32253 1016
type: UnificationXref
id: P32253
db: uniprot

uniprot P17252 600
type: UnificationXref
id: P17252
db: uniprot

uniprot F7FFF4 302
type: UnificationXref
id: F7FFF4
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1Q118 167
xref: PTHR23113:SF168
organism: Canis lupus familiaris

uniprot A0A2I3TRY9 885
type: UnificationXref
id: A0A2I3TRY9
db: uniprot

uniprot Q9JHG7 966
type: UnificationXref
id: Q9JHG7
db: uniprot

Nck
type: Protein
entity reference: Nck
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P47809 245
type: UnificationXref
id: P47809
db: uniprot

STATE_TRANSITION_LEFT__SPK-RIGHT__SPK-_r283
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r283 1369
participant stoichiometry: PARTICIPANT STOICHIOMETRY r283 1368
left: SPK
interaction type: STATE_TRANSITION
right: SPK

uniprot P27704 705
type: UnificationXref
id: P27704
db: uniprot

uniprot Q9Z1K7 220
type: UnificationXref
id: Q9Z1K7
db: uniprot

uniprot Q8SQ01 161
type: UnificationXref
id: Q8SQ01
db: uniprot

uniprot P24257 366
type: UnificationXref
id: P24257
db: uniprot

Rho-related GTP-binding protein RhoA-A
type: ProteinReference
xref: uniprot Q6NUX8 1244
xref: PTHR24072:SF100
organism: Danio rerio

uniprot P30931 153
type: UnificationXref
id: P30931
db: uniprot

uniprot P42338 946
type: UnificationXref
id: P42338
db: uniprot

NRAS protein
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot A5D7R9 987
organism: Bos taurus

uniprot A0A3Q1N508 422
type: UnificationXref
id: A0A3Q1N508
db: uniprot

uniprot Q92569 964
type: UnificationXref
id: Q92569
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QK27 519
xref: PTHR10454:SF157
organism: Macaca mulatta

Transcription factor 7-like 2
type: ProteinReference
xref: uniprot Q924A0 1064
xref: PTHR10373:SF32
organism: Mus musculus

uniprot A0A3Q2UCS9 840
type: UnificationXref
id: A0A3Q2UCS9
db: uniprot

Eph
type: Protein
entity reference: Eph
comment: SPECIES_TYPE=PROTEIN

PTHR19969:SF20
type: RelationshipXref
id: PTHR19969:SF20
db: PANTHER Family
relationship type: By Homology

uniprot F1PS94 1257
type: UnificationXref
id: F1PS94
db: uniprot

Frizzled class receptor 2
type: ProteinReference
xref: uniprot F6SH04 122
xref: PTHR11309:SF34
organism: Xenopus tropicalis

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q9Z1L0 968
organism: Rattus norvegicus

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P79737 1018
organism: Danio rerio

Eph s19 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Eph
stoichiometric coefficient: 1.0

uniprot Q9EQD0 138
type: UnificationXref
id: Q9EQD0
db: uniprot

Leupaxin
type: ProteinReference
xref: uniprot O60711 195
organism: Homo sapiens

uniprot A0A1D5R9U8 1066
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

Adenomatous polyposis coli protein 2
type: ProteinReference
xref: uniprot Q9Z1K7 220
xref: PTHR12607:SF3
organism: Mus musculus

Frizzled class receptor 2
type: ProteinReference
xref: PTHR11309:SF34
xref: uniprot G3N2W8 125
organism: Bos taurus

PTHR19969:SF12
type: RelationshipXref
id: PTHR19969:SF12
db: PANTHER Family
relationship type: By Homology

uniprot Q3UMW7 1104
type: UnificationXref
id: Q3UMW7
db: uniprot

PTHR19969:SF16
type: RelationshipXref
id: PTHR19969:SF16
db: PANTHER Family
relationship type: By Homology

PTHR10194:SF19
type: RelationshipXref
id: PTHR10194:SF19
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re109
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re109 1463
participant stoichiometry: PARTICIPANT STOICHIOMETRY re109 1462
left: beta catenin
interaction type: STATE_TRANSITION
right: beta catenin

Grb2
type: Protein
entity reference: Grb2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Neurogenic locus notch homolog protein 2
type: ProteinReference
xref: PTHR22804:SF52
xref: uniprot Q9QW30 1269
organism: Rattus norvegicus

Ras protein let-60
type: ProteinReference
xref: uniprot P22981 1014
organism: Caenorhabditis elegans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__STAT1-RIGHT__STAT1-_r253
controller: JAK1

STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r296
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r296 1535
participant stoichiometry: PARTICIPANT STOICHIOMETRY r296 1536
left: Rac
interaction type: STATE_TRANSITION
right: Rac

uniprot Q05713 829
type: UnificationXref
id: Q05713
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r234
controller: Erk

eNOS
type: Protein
entity reference: eNOS
feature: ACTIVE 25
feature: COMPLEX PARTICIPANT BINDING FEATURE s208 sa26 1327
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q08BT6 617
type: UnificationXref
id: Q08BT6
db: uniprot

uniprot F6XUP1 1160
type: UnificationXref
id: F6XUP1
db: uniprot

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot F1PHV7 1000
organism: Canis lupus familiaris

uniprot P20786 793
type: UnificationXref
id: P20786
db: uniprot

Shp-2
type: Protein
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q8CHL0 137
type: UnificationXref
id: Q8CHL0
db: uniprot

uniprot O73791 1147
type: UnificationXref
id: O73791
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q2TY19 643
xref: PTHR24055:SF222
organism: Gallus gallus

PLA2
type: ProteinReference
xref: P00227
standard name: Phospholipase A2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phospholiase A2 Synonym: CPLA2,PLA2 Accession: P00227
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.PLA_sub_2_endsub
member entity reference: Cytosolic phospholipase A2
member entity reference: Phospholipase A2

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot E7EXT6 656
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTPase-RIGHT__GTPase-_r156
controller: PAR

uniprot Q28HZ4 1235
type: UnificationXref
id: Q28HZ4
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7DUD6 915
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

uniprot Q9JI71 758
type: UnificationXref
id: Q9JI71
db: uniprot

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

PTHR10878:SF8
type: RelationshipXref
id: PTHR10878:SF8
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r205
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r205 1432
participant stoichiometry: PARTICIPANT STOICHIOMETRY r205 1431
left: PKC
interaction type: STATE_TRANSITION
right: PKC

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 36
xref: PTHR24055:SF110
organism: Pan troglodytes

uniprot Q02956 613
type: UnificationXref
id: Q02956
db: uniprot

PTHR10878:SF5
type: RelationshipXref
id: PTHR10878:SF5
db: PANTHER Family
relationship type: By Homology

PTHR10878:SF6
type: RelationshipXref
id: PTHR10878:SF6
db: PANTHER Family
relationship type: By Homology

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot F7CU42 1162
organism: Monodelphis domestica

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6QP11 660
xref: PTHR24356:SF171
organism: Monodelphis domestica

uniprot P28159 850
type: UnificationXref
id: P28159
db: uniprot

uniprot A0A2I3TN31 1045
type: UnificationXref
id: A0A2I3TN31
db: uniprot

Tissue factor
type: ProteinReference
xref: PTHR20859:SF22
xref: uniprot P30931 153
organism: Bos taurus

uniprot E1B8P9 282
type: UnificationXref
id: E1B8P9
db: uniprot

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot E2RL20 1076
organism: Canis lupus familiaris

Secreted frizzled-related protein 1
type: ProteinReference
xref: uniprot F7EN59 975
xref: PTHR11309:SF87
organism: Xenopus tropicalis

Novel Rho protein
type: ProteinReference
xref: uniprot Q28HZ4 1235
xref: PTHR24072:SF100
organism: Xenopus tropicalis

uniprot F7BFL2 1095
type: UnificationXref
id: F7BFL2
db: uniprot

uniprot A0A3Q1M0G8 1152
type: UnificationXref
id: A0A3Q1M0G8
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A8XTZ1 1274
organism: Caenorhabditis briggsae

Si:dkeyp-80c12.7
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot B8JIQ1 442
organism: Danio rerio

c-Jun
type: ProteinReference
xref: P00220
standard name: c-Jun Transcription Factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: c-Jun Transcription Factor Synonym: AP-1,Activator Protein 1,Oncogene Jun,v-Jun Avian Sarcoma Virus 17 Oncogene Homolog Accession: P00220
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.c-Jun
member entity reference: Transcription factor AP-1
member entity reference: Jun proto-oncogene
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit

uniprot P23727 940
type: UnificationXref
id: P23727
db: uniprot

PTHR12027:SF89
type: RelationshipXref
id: PTHR12027:SF89
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR21258:SF40
xref: uniprot E1C021 1049
organism: Gallus gallus

uniprot Q5FWK3 1122
type: UnificationXref
id: Q5FWK3
db: uniprot

PTHR12027:SF87
type: RelationshipXref
id: PTHR12027:SF87
db: PANTHER Family
relationship type: By Homology

uniprot F1Q118 167
type: UnificationXref
id: F1Q118
db: uniprot

uniprot P28482 293
type: UnificationXref
id: P28482
db: uniprot

PARTICIPANT STOICHIOMETRY r277 1397
type: Stoichiometry
physical entity: Complex (cPLA2_endsub/Ca2+_endsuper)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r277 1396
type: Stoichiometry
physical entity: cPLA2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r277 1395
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

FRZB isoform 1
type: ProteinReference
xref: uniprot H2QJ36 976
xref: PTHR11309:SF97
organism: Pan troglodytes

ncbitaxon 7739 328
type: UnificationXref
id: 7739
db: ncbitaxon

CRK like proto-oncogene, adaptor protein
type: ProteinReference
xref: uniprot H2R472 402
xref: PTHR19969:SF20
organism: Pan troglodytes

PTHR12027:SF93
type: RelationshipXref
id: PTHR12027:SF93
db: PANTHER Family
relationship type: By Homology

CSL
type: ProteinReference
xref: P00233
standard name: CBF1, Suppressor of Hairless, Lag-1 Transcription Factor Family
comment: ENTITY_REFERENCE_NOTES=Long Name: CBF1, Suppressor of Hairless, Lag-1 Transcription Factor Family Synonym: C Promoter-Binding Factor 1,CBF1,IGKJRB,Immunoglobulin Kappa J Region Recombination Signal-Binding Protein,RBPJK,RBPSUH,Recombination Signal-Binding Protein 1 for J-Kappa,Recombination Signal-Binding Protein Suppressor of Hairless Accession: P00233
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.CSL
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Recombining binding protein suppressor of hairless-like protein
member entity reference: Recombination signal-binding protein for immunoglobulin kappa J region-like
member entity reference: Recombination signal binding protein for immunoglobulin kappa J region
member entity reference: RBPJ isoform 12
member entity reference: Recombining binding protein suppressor of hairless
member entity reference: Uncharacterized protein
member entity reference: Recombination signal-binding protein for immunoglobulin kappa J region
member entity reference: RBPJL isoform 1
member entity reference: Suppressor of hairless homolog
member entity reference: Rbpja protein
member entity reference: Suppressor of hairless protein
member entity reference: Lin-12 And Glp-1 phenotype

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_r291
controller: FAK

uniprot Q812A5 1124
type: UnificationXref
id: Q812A5
db: uniprot

PTHR12027:SF91
type: RelationshipXref
id: PTHR12027:SF91
db: PANTHER Family
relationship type: By Homology

Notch
type: Protein
entity reference: Notch
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa1 1315
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PDGFD protein
type: ProteinReference
xref: PTHR11633:SF4
xref: uniprot A4IFC0 681
organism: Bos taurus

uniprot Q14332 135
type: UnificationXref
id: Q14332
db: uniprot

GTP-binding protein RHO1
type: ProteinReference
xref: uniprot O42825 1217
organism: Candida albicans

uniprot Q6C4X3 1239
type: UnificationXref
id: Q6C4X3
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot Q9YGX6 393
xref: PTHR12027:SF33
organism: Gallus gallus

MODULATION
type: RelationshipTypeVocabulary

FZD1 protein
type: ProteinReference
xref: uniprot A7MB15 110
xref: PTHR11309:SF81
organism: Bos taurus

PTHR12027:SF98
type: RelationshipXref
id: PTHR12027:SF98
db: PANTHER Family
relationship type: By Homology

GRB2-related adapter protein
type: ProteinReference
xref: uniprot Q13588 861
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r190 1555
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

Ephrin-B2a
type: ProteinReference
xref: uniprot O73874 1036
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r190 1554
type: Stoichiometry
physical entity: GSK3beta
stoichiometric coefficient: 1.0

uniprot E1BDG5 332
type: UnificationXref
id: E1BDG5
db: uniprot

PARTICIPANT STOICHIOMETRY r190 1557
type: Stoichiometry
physical entity: Complex (Axin/APC/ GSK3beta)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r190 1556
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

uniprot Q9EQX6 700
type: UnificationXref
id: Q9EQX6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Erk-RIGHT__Erk-_r278
controller: MEK

uniprot F1PXS7 284
type: UnificationXref
id: F1PXS7
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot G7MGQ5 923
organism: Macaca mulatta

Recombining binding protein suppressor of hairless
type: ProteinReference
xref: uniprot Q3SZ41 853
xref: PTHR10665:SF3
organism: Bos taurus

uniprot P13109 490
type: UnificationXref
id: P13109
db: uniprot

uniprot Q8CI15 801
type: UnificationXref
id: Q8CI15
db: uniprot

PLD
type: Protein
entity reference: PLD
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot H9FU32 1078
type: UnificationXref
id: H9FU32
db: uniprot

PTHR12027:SF73
type: RelationshipXref
id: PTHR12027:SF73
db: PANTHER Family
relationship type: By Homology

Notch s2 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Notch
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r230
controller: SOS-1

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot D4A229 554
organism: Rattus norvegicus

uniprot Q62600 438
type: UnificationXref
id: Q62600
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JAK1-RIGHT__JAK1-_r252
controller: Complex (PDGFR/PDGF)

PTHR48015:SF30
type: RelationshipXref
id: PTHR48015:SF30
db: PANTHER Family
relationship type: By Homology

Sphingosine kinase 2
type: ProteinReference
xref: uniprot Q9NRA0 803
organism: Homo sapiens

Platelet-derived growth factor C
type: ProteinReference
xref: uniprot Q9NRA1 703
organism: Homo sapiens

uniprot F6R8N3 661
type: UnificationXref
id: F6R8N3
db: uniprot

PI3K
type: Protein
entity reference: PI3K
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Delta/Serrate
type: Protein
entity reference: Delta/Serrate
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 6669 993
type: UnificationXref
id: 6669
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6YAB9 29
organism: Monodelphis domestica

uniprot P21708 291
type: UnificationXref
id: P21708
db: uniprot

uniprot H2QPH6 636
type: UnificationXref
id: H2QPH6
db: uniprot

PTHR12027:SF77
type: RelationshipXref
id: PTHR12027:SF77
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF76
type: RelationshipXref
id: PTHR12027:SF76
db: PANTHER Family
relationship type: By Homology

PTHR12027:SF78
type: RelationshipXref
id: PTHR12027:SF78
db: PANTHER Family
relationship type: By Homology

Akt
type: Protein
entity reference: Akt
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Dishevelled segment polarity protein 2
type: ProteinReference
xref: uniprot E2R7K2 252
xref: PTHR10878:SF8
organism: Canis lupus familiaris

PTHR12027:SF86
type: RelationshipXref
id: PTHR12027:SF86
db: PANTHER Family
relationship type: By Homology

uniprot O70469 16
type: UnificationXref
id: O70469
db: uniprot

uniprot F7BUF3 729
type: UnificationXref
id: F7BUF3
db: uniprot

Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
type: ProteinReference
xref: uniprot D3ZTF6 891
xref: PTHR10048:SF28
organism: Rattus norvegicus

uniprot F6QE96 659
type: UnificationXref
id: F6QE96
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF73
xref: uniprot X1WEJ5 394
organism: Danio rerio

Serine/threonine-protein kinase akt-2
type: ProteinReference
xref: uniprot Q9XTG7 677
organism: Caenorhabditis elegans

GSK3beta
type: Protein
entity reference: GSK3beta
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Glycogen synthase kinase 3
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot Q9YH60 454
organism: Danio rerio

PTHR45976:SF4
type: RelationshipXref
id: PTHR45976:SF4
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot F1N6L8 337
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F7G800 1163
organism: Monodelphis domestica

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot Q9DEB8 388
organism: Gallus gallus

STATE_TRANSITION_LEFT__TCF-RIGHT__TCF-_r189
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r189 1371
participant stoichiometry: PARTICIPANT STOICHIOMETRY r189 1370
left: TCF
interaction type: STATE_TRANSITION
right: TCF

uniprot O70283 358
type: UnificationXref
id: O70283
db: uniprot

Protein tyrosine kinase 2ab
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot A0A2R8RR02 421
organism: Danio rerio

uniprot Q15389 1141
type: UnificationXref
id: Q15389
db: uniprot

uniprot P48148 1224
type: UnificationXref
id: P48148
db: uniprot

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: uniprot Q5RKN6 863
xref: PTHR46037:SF4
organism: Danio rerio

PTHR10155:SF3
type: RelationshipXref
id: PTHR10155:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q8I009 237
type: UnificationXref
id: Q8I009
db: uniprot

uniprot F6YAB9 29
type: UnificationXref
id: F6YAB9
db: uniprot

GTP-binding protein rhoA
type: ProteinReference
xref: uniprot Q9C3Y4 1246
organism: Emericella nidulans

uniprot F1QD56 1181
type: UnificationXref
id: F1QD56
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r180
controller: Complex (EphR/Eph)

uniprot O02812 31
type: UnificationXref
id: O02812
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot A6H6X8 324
xref: PTHR12027:SF93
organism: Bos taurus

uniprot H2QRB5 213
type: UnificationXref
id: H2QRB5
db: uniprot

STATE_TRANSITION_LEFT__HIF_1-RIGHT__HIF_1-_r276
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r276 1399
participant stoichiometry: PARTICIPANT STOICHIOMETRY r276 1398
left: HIF-1
interaction type: STATE_TRANSITION
right: HIF-1

PTHR10155:SF2
type: RelationshipXref
id: PTHR10155:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF1
type: RelationshipXref
id: PTHR10155:SF1
db: PANTHER Family
relationship type: By Homology

uniprot E1BMX0 991
type: UnificationXref
id: E1BMX0
db: uniprot

uniprot P15064 1013
type: UnificationXref
id: P15064
db: uniprot

FRS3 protein
type: ProteinReference
xref: uniprot A6H792 1046
organism: Bos taurus

Eph receptor B3
type: ProteinReference
xref: PTHR24416:SF120
xref: uniprot D3ZH39 460
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPR8 40
xref: PTHR10337:SF2
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P19174 1283
organism: Homo sapiens

uniprot B1WBR9 326
type: UnificationXref
id: B1WBR9
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A1D5QE27 880
xref: PTHR10048:SF7
organism: Macaca mulatta

Multifunctional fusion protein
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot A0A2J8NIY5 484
organism: Pan troglodytes

uniprot Q8WU20 1057
type: UnificationXref
id: Q8WU20
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SOS_1-RIGHT__SOS_1-_r226
controller: GRB2

PARTICIPANT STOICHIOMETRY r230 1543
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r230 1542
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Ephrin-B1
type: ProteinReference
xref: uniprot A0A2R8Q1M3 1026
organism: Danio rerio

Protein Wnt
type: ProteinReference
xref: uniprot D4A9J2 331
xref: PTHR12027:SF91
organism: Rattus norvegicus

uniprot Q6DHE8 1242
type: UnificationXref
id: Q6DHE8
db: uniprot

uniprot P97813 310
type: UnificationXref
id: P97813
db: uniprot

Notch 4
type: ProteinReference
xref: uniprot Q6MG89 1267
xref: PTHR24044:SF470
organism: Rattus norvegicus

uniprot Q8MML5 204
type: UnificationXref
id: Q8MML5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K5T3 879
organism: Rattus norvegicus

TEK receptor tyrosine kinase
type: ProteinReference
xref: uniprot F1P8U6 1145
xref: PTHR24416:SF125
organism: Canis lupus familiaris

PTHR12027:SF33
type: RelationshipXref
id: PTHR12027:SF33
db: PANTHER Family
relationship type: By Homology

Survivin
type: Protein
entity reference: Survivin
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

By Homology
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r237 1522
type: Stoichiometry
physical entity: PDGF
stoichiometric coefficient: 1.0

Protein Wnt-10a
type: ProteinReference
xref: uniprot P70701 376
xref: PTHR12027:SF89
organism: Mus musculus

Docking protein 1
type: ProteinReference
xref: uniprot Q99704 23
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r237 1523
type: Stoichiometry
physical entity: PDGFR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r237 1524
type: Stoichiometry
physical entity: Complex (PDGFR/PDGF)
stoichiometric coefficient: 1.0

uniprot Q9WU82 96
type: UnificationXref
id: Q9WU82
db: uniprot

uniprot A0A2R8Q8S1 986
type: UnificationXref
id: A0A2R8Q8S1
db: uniprot

PTHR20859:SF22
type: RelationshipXref
id: PTHR20859:SF22
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Grb2-RIGHT__Grb2-_r272
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r272 1408
participant stoichiometry: PARTICIPANT STOICHIOMETRY r272 1409
left: Grb2
interaction type: STATE_TRANSITION
right: Grb2

Focal adhesion kinase 1
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot O35346 427
organism: Rattus norvegicus

Phospholipase D1
type: ProteinReference
xref: uniprot Q9Z280 314
xref: PTHR18896:SF57
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EI48 287
xref: PTHR24055:SF393
organism: Monodelphis domestica

uniprot Q14451 783
type: UnificationXref
id: Q14451
db: uniprot

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 766
xref: uniprot A4IFJ5 765
xref: PTHR10728:SF13
organism: Bos taurus

Protein CBR-RGA-1
type: ProteinReference
xref: uniprot A8WTA3 1109
organism: Caenorhabditis briggsae

uniprot P42225 537
type: UnificationXref
id: P42225
db: uniprot

beta catenin
type: ProteinReference
xref: P00187
standard name: Beta-catenin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Beta-catenin Synonym: Beta,CTNNB,Cadherin-Associated Protein Accession: P00187
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC._beta__space_catenin
member entity reference: Catenin beta-1
member entity reference: CTNNB1 isoform 2
member entity reference: Catenin (Cadherin-associated protein), beta 1, 88kDa
member entity reference: Uncharacterized protein
member entity reference: Armadillo segment polarity protein
member entity reference: Catenin beta 1
member entity reference: Catenin, beta 2

Phospholipase D2
type: ProteinReference
xref: PTHR18896:SF121
xref: uniprot O14939 307
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: uniprot E2RTG8 335
xref: PTHR12027:SF91
organism: Canis lupus familiaris

SOS-1
type: Protein
entity reference: SOS-1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P10686 1281
type: UnificationXref
id: P10686
db: uniprot

uniprot H2QMP5 1098
type: UnificationXref
id: H2QMP5
db: uniprot

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P04792 822
organism: Homo sapiens

TRANSPORT
type: RelationshipTypeVocabulary

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 1206

Ras-like protein rasB
type: ProteinReference
xref: uniprot P32252 1015
organism: Dictyostelium discoideum

Delta-like protein
type: ProteinReference
xref: uniprot F6VUQ4 728
xref: PTHR24044:SF448
organism: Ornithorhynchus anatinus

AGAP000018-PA
type: ProteinReference
xref: uniprot Q7QEJ7 961
organism: Anopheles gambiae

Ras-like protein rasS
type: ProteinReference
xref: uniprot P32254 1017
organism: Dictyostelium discoideum

Ras-like protein rasC
type: ProteinReference
xref: uniprot P32253 1016
organism: Dictyostelium discoideum

uniprot H2R9U6 977
type: UnificationXref
id: H2R9U6
db: uniprot

uniprot A0A1D5QXL5 99
type: UnificationXref
id: A0A1D5QXL5
db: uniprot

Neurogenic locus protein delta
type: ProteinReference
xref: uniprot P10041 743
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r204 1433
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r204 1434
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r204 1435
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

eco ECO:0000305 984
type: UnificationXref
id: ECO:0000305
db: eco

Tyrosine-protein kinase Src64B
type: ProteinReference
xref: uniprot P00528 56
organism: Drosophila melanogaster

uniprot P09619 791
type: UnificationXref
id: P09619
db: uniprot

PARTICIPANT STOICHIOMETRY r178 1407
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 1.0

uniprot A0A1D5R2V9 63
type: UnificationXref
id: A0A1D5R2V9
db: uniprot

PARTICIPANT STOICHIOMETRY r178 1406
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot E1BMX0 991
organism: Bos taurus

uniprot P53349 417
type: UnificationXref
id: P53349
db: uniprot

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot P00523 54
organism: Gallus gallus

Transforming growth factor beta 1 induced transcript 1
type: ProteinReference
xref: uniprot E2RTE0 192
organism: Canis lupus familiaris

uniprot Q62077 1285
type: UnificationXref
id: Q62077
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 18

uniprot P42227 531
type: UnificationXref
id: P42227
db: uniprot

PARTICIPANT STOICHIOMETRY r255 1470
type: Stoichiometry
physical entity: Survivin
stoichiometric coefficient: 1.0

uniprot A0A2I3RGF5 714
type: UnificationXref
id: A0A2I3RGF5
db: uniprot

uniprot K7CZM1 174
type: UnificationXref
id: K7CZM1
db: uniprot

Frizzled class receptor 3
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot F6RPG1 121
organism: Xenopus tropicalis

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot Q3SYZ2 1103
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r255 1469
type: Stoichiometry
physical entity: Survivin
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6T2E7 1158
xref: PTHR48015:SF22
organism: Xenopus tropicalis

PTHR11849:SF209
type: RelationshipXref
id: PTHR11849:SF209
db: PANTHER Family
relationship type: By Homology

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot F7GWI2 1164
organism: Macaca mulatta

uniprot P20033 693
type: UnificationXref
id: P20033
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45836:SF12
xref: uniprot F7H8I5 1258
organism: Macaca mulatta

Protein Wnt
type: ProteinReference
xref: uniprot F6PMQ6 338
xref: PTHR12027:SF33
organism: Monodelphis domestica

uniprot A8XTZ1 1274
type: UnificationXref
id: A8XTZ1
db: uniprot

Tie2 s225 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tie2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r271 1413
type: Stoichiometry
physical entity: Dok-R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r271 1412
type: Stoichiometry
physical entity: Dok-R
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 30

Growth factor receptor-bound protein 14
type: ProteinReference
xref: uniprot Q9JLM9 231
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F1NG47 568
organism: Gallus gallus

uniprot O35878 816
type: UnificationXref
id: O35878
db: uniprot

Frizzled-2
type: ProteinReference
xref: PTHR11309:SF34
xref: uniprot Q14332 135
organism: Homo sapiens

DOK1 isoform 3
type: ProteinReference
xref: uniprot H2QI72 11
organism: Pan troglodytes

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7FWN9 53
xref: PTHR24418:SF53
organism: Macaca mulatta

uniprot P29323 476
type: UnificationXref
id: P29323
db: uniprot

uniprot P15056 1086
type: UnificationXref
id: P15056
db: uniprot

uniprot A0A2J8NIY5 484
type: UnificationXref
id: A0A2J8NIY5
db: uniprot

uniprot F6XER9 399
type: UnificationXref
id: F6XER9
db: uniprot

uniprot C3Z2P0 329
type: UnificationXref
id: C3Z2P0
db: uniprot

uniprot H2QHR7 585
type: UnificationXref
id: H2QHR7
db: uniprot

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 356

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LMC7 211
xref: PTHR12607:SF11
organism: Bos taurus

PTHR48015:SF22
type: RelationshipXref
id: PTHR48015:SF22
db: PANTHER Family
relationship type: By Homology

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: uniprot Q61221 504
xref: PTHR23043:SF7
organism: Mus musculus

PTHR48015:SF20
type: RelationshipXref
id: PTHR48015:SF20
db: PANTHER Family
relationship type: By Homology

uniprot O73682 1059
type: UnificationXref
id: O73682
db: uniprot

Fibroblast growth factor 2
type: ProteinReference
xref: uniprot P48800 494
organism: Gallus gallus

Notch
type: Protein
entity reference: Notch
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot I2CVK6 737
type: UnificationXref
id: I2CVK6
db: uniprot

uniprot F0ZWE6 998
type: UnificationXref
id: F0ZWE6
db: uniprot

uniprot A0A2I3SIH9 47
type: UnificationXref
id: A0A2I3SIH9
db: uniprot

PTHR10728:SF13
type: RelationshipXref
id: PTHR10728:SF13
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3S045 715
type: UnificationXref
id: A0A2I3S045
db: uniprot

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot A0A2I3RMA9 64
xref: PTHR24416:SF131
organism: Pan troglodytes

Platelet-derived growth factor alpha polypeptide a
type: ProteinReference
xref: uniprot A5PMP7 682
organism: Danio rerio

uniprot F1MY82 567
type: UnificationXref
id: F1MY82
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot F6Y9I6 572
xref: PTHR22968:SF9
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS_-_eNOS-RIGHT__Complex__eNOS_Ca2_PLUS_-_r256
controller: Akt

uniprot P35222 92
type: UnificationXref
id: P35222
db: uniprot

Angiopoietin-2
type: ProteinReference
xref: PTHR19143:SF199
xref: uniprot A0A8J8 1127
organism: Canis lupus familiaris

uniprot Q13588 861
type: UnificationXref
id: Q13588
db: uniprot

Serine/threonine-protein kinase D2
type: ProteinReference
xref: uniprot Q9BZL6 630
xref: PTHR22968:SF12
organism: Homo sapiens

uniprot P98083 44
type: UnificationXref
id: P98083
db: uniprot

uniprot O60711 195
type: UnificationXref
id: O60711
db: uniprot

Heat shock protein family B (small) member 2
type: ProteinReference
xref: uniprot E2RTA9 809
organism: Canis lupus familiaris

FZD3 isoform 1
type: ProteinReference
xref: uniprot A0A2J8N8E6 108
xref: PTHR11309:SF22
organism: Pan troglodytes

uniprot D3ZHJ4 9
type: UnificationXref
id: D3ZHJ4
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q92569 964
organism: Homo sapiens

Recombining binding protein suppressor of hairless-like protein
type: ProteinReference
xref: PTHR10665:SF2
xref: uniprot O08674 848
organism: Mus musculus

STATE_TRANSITION_LEFT__Src-RIGHT__Src-_r220
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r220 1363
participant stoichiometry: PARTICIPANT STOICHIOMETRY r220 1364
left: Src
interaction type: STATE_TRANSITION
right: Src

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 1067
evidence: Evidence 1070
evidence: Evidence 1068
evidence: Evidence 1069
xref: PTHR44329:SF22
xref: uniprot A0A2I3THL4 1071
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK1-RIGHT__JNK1-_r246
controller: JNKK1

ncbitaxon 9615 32
type: UnificationXref
id: 9615
db: ncbitaxon

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7GAP5 920
organism: Ornithorhynchus anatinus

PTHR10728:SF32
type: RelationshipXref
id: PTHR10728:SF32
db: PANTHER Family
relationship type: By Homology

uniprot P48798 493
type: UnificationXref
id: P48798
db: uniprot

STATE_TRANSITION_LEFT__PLA2-RIGHT__PLA2-_r207
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r207 1426
participant stoichiometry: PARTICIPANT STOICHIOMETRY r207 1425
left: PLA2
interaction type: STATE_TRANSITION
right: PLA2

uniprot Q9NL43 451
type: UnificationXref
id: Q9NL43
db: uniprot

Src
type: ProteinReference
xref: P00184
standard name: Src tyrosine kinase
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Src
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Src Kinase Synonym: Avian Sarcoma Viral Oncogene,Src Oncogene Accession: P00184
member entity reference: Tyrosine-protein kinase
member entity reference: Proto-oncogene tyrosine-protein kinase Src
member entity reference: Neuronal proto-oncogene tyrosine-protein kinase Src
member entity reference: Tyrosine-protein kinase Src64B

uniprot F7HRY3 257
type: UnificationXref
id: F7HRY3
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O00329 929
xref: PTHR10048:SF35
organism: Homo sapiens

uniprot P05129 592
type: UnificationXref
id: P05129
db: uniprot

Frizzled class receptor 5
type: ProteinReference
xref: PTHR11309:SF136
xref: uniprot E2QVP7 113
organism: Canis lupus familiaris

uniprot F6XWP7 1191
type: UnificationXref
id: F6XWP7
db: uniprot

Docking protein 2
type: ProteinReference
xref: uniprot D3ZHJ4 9
organism: Rattus norvegicus

Platelet-derived growth factor receptor beta
type: ProteinReference
xref: PTHR24416:SF53
xref: uniprot A0A3Q1N3Z8 786
organism: Bos taurus

uniprot B2B9A9 1028
type: UnificationXref
id: B2B9A9
db: uniprot

uniprot F6Y1Z2 103
type: UnificationXref
id: F6Y1Z2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r232
controller: Raf

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r204
controller: PLC-gamma

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R3Z3 837
xref: PTHR10665:SF3
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR46771:SF3
xref: uniprot F1NN48 232
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r250 1488
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r250 1487
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PTHR10454:SF157
type: RelationshipXref
id: PTHR10454:SF157
db: PANTHER Family
relationship type: By Homology

Crk
type: ProteinReference
xref: P00207
standard name: Crk oncogene
comment: ENTITY_REFERENCE_NOTES=Long Name: Crk oncogene Synonym: CRKII Accession: P00207
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Crk
member entity reference: AGAP009499-PA
member entity reference: Crk-like protein
member entity reference: Adapter molecule crk
member entity reference: V-crk avian sarcoma virus CT10 oncogene homolog-like
member entity reference: CRK like proto-oncogene, adaptor protein
member entity reference: CRK proto-oncogene, adaptor protein
member entity reference: Uncharacterized protein
member entity reference: V-crk avian sarcoma virus CT10 oncogene homolog
member entity reference: Cell death abnormality protein 2
member entity reference: Adapter molecule Crk

uniprot P41221 372
type: UnificationXref
id: P41221
db: uniprot

Delta-like protein 4
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot D3ZHH1 719
organism: Rattus norvegicus

uniprot Q7KTZ2 959
type: UnificationXref
id: Q7KTZ2
db: uniprot

uniprot A0A0G2JZZ5 1044
type: UnificationXref
id: A0A0G2JZZ5
db: uniprot

uniprot Q9CR99 1248
type: UnificationXref
id: Q9CR99
db: uniprot

GRB2-related adapter protein
type: ProteinReference
xref: uniprot F7GJG7 858
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Src-RIGHT__Src-_r288
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r288 1350
participant stoichiometry: PARTICIPANT STOICHIOMETRY r288 1349
left: Src
interaction type: STATE_TRANSITION
right: Src

Serine/threonine-protein kinase D1
type: ProteinReference
xref: PTHR22968:SF9
xref: uniprot Q15139 618
organism: Homo sapiens

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A2I3TRY9 885
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r284
controller: PLC-gamma

Cytosolic phospholipase A2 gamma
type: ProteinReference
xref: uniprot Q64GA5 1186
organism: Mus musculus

Ephrin type-A receptor 3
type: ProteinReference
xref: uniprot O08680 471
organism: Rattus norvegicus

uniprot F7GAP5 920
type: UnificationXref
id: F7GAP5
db: uniprot

uniprot P32871 943
type: UnificationXref
id: P32871
db: uniprot

Suppressor of hairless protein
type: ProteinReference
xref: uniprot P28159 850
organism: Drosophila melanogaster

Docking protein 3
type: ProteinReference
xref: uniprot Q7L591 22
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XP81 663
xref: PTHR24356:SF171
organism: Xenopus tropicalis

uniprot Q08464 133
type: UnificationXref
id: Q08464
db: uniprot

uniprot A0A3Q1LQK4 887
type: UnificationXref
id: A0A3Q1LQK4
db: uniprot

uniprot P12931 59
type: UnificationXref
id: P12931
db: uniprot

uniprot H9FYU7 173
type: UnificationXref
id: H9FYU7
db: uniprot

uniprot O00744 355
type: UnificationXref
id: O00744
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPKAPK2_3-RIGHT__MAPKAPK2_3-_r293
controller: p38MAPK

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7G8G5 528
xref: PTHR11801:SF2
organism: Macaca mulatta

uniprot F7BAS2 1161
type: UnificationXref
id: F7BAS2
db: uniprot

uniprot F6PWM3 117
type: UnificationXref
id: F6PWM3
db: uniprot

Proline-rich protein 5
type: ProteinReference
xref: uniprot Q5FVG6 1121
organism: Rattus norvegicus

uniprot A8KBH6 552
type: UnificationXref
id: A8KBH6
db: uniprot

uniprot A0A1D5R589 210
type: UnificationXref
id: A0A1D5R589
db: uniprot

uniprot O73874 1036
type: UnificationXref
id: O73874
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 8

uniprot O70239 1197
type: UnificationXref
id: O70239
db: uniprot

uniprot P42337 945
type: UnificationXref
id: P42337
db: uniprot

uniprot E2R9U3 723
type: UnificationXref
id: E2R9U3
db: uniprot

Delta Serrate s15 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Delta/Serrate
stoichiometric coefficient: 1.0

uniprot Q9DEQ4 983
type: UnificationXref
id: Q9DEQ4
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

uniprot Q60631 864
type: UnificationXref
id: Q60631
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot E1BWA3 558
xref: PTHR24356:SF214
organism: Gallus gallus

Secreted frizzled-related protein 1
type: ProteinReference
xref: uniprot F6SGW3 972
xref: PTHR11309:SF87
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC_gamma-RIGHT__PLC_gamma-_r285
controller: Complex (VEGFR-2/VEGF)

uniprot A0A2I3THL4 1071
type: UnificationXref
id: A0A2I3THL4
db: uniprot

LD28067p
type: ProteinReference
xref: uniprot Q7K3H0 958
organism: Drosophila melanogaster

Vascular endothelial growth factor receptor 2
type: ProteinReference
xref: uniprot P35918 637
organism: Mus musculus

uniprot A6H792 1046
type: UnificationXref
id: A6H792
db: uniprot

Pak
type: Protein
entity reference: Pak
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q8CIN4 1177
type: UnificationXref
id: Q8CIN4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Erk-RIGHT__Erk-_r233
controller: MEK

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot G3X7B5 665
xref: PTHR24351:SF200
organism: Bos taurus

uniprot Q8BZ03 627
type: UnificationXref
id: Q8BZ03
db: uniprot

PARTICIPANT STOICHIOMETRY r254 1473
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r254 1474
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

uniprot P62746 1228
type: UnificationXref
id: P62746
db: uniprot

Proteinase-activated receptor 1
type: ProteinReference
xref: uniprot P26824 159
organism: Rattus norvegicus

uniprot F1NMJ9 76
type: UnificationXref
id: F1NMJ9
db: uniprot

PTHR11304:SF18
type: RelationshipXref
id: PTHR11304:SF18
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r175
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r175 1419
participant stoichiometry: PARTICIPANT STOICHIOMETRY r175 1418
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

uniprot H2Q8F2 582
type: UnificationXref
id: H2Q8F2
db: uniprot

uniprot M0R7Q3 847
type: UnificationXref
id: M0R7Q3
db: uniprot

uniprot O77627 541
type: UnificationXref
id: O77627
db: uniprot

Frizzled class receptor 5
type: ProteinReference
xref: PTHR11309:SF139
xref: uniprot B3DIG4 112
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK1-RIGHT__MEKK1-_r244
controller: MEK

uniprot A0A2I3TJU8 520
type: UnificationXref
id: A0A2I3TJU8
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_re106
control type: ACTIVATION
controller: Akt

uniprot P29353 42
type: UnificationXref
id: P29353
db: uniprot

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r282
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r282 1372
participant stoichiometry: PARTICIPANT STOICHIOMETRY r282 1373
left: PKC
interaction type: STATE_TRANSITION
right: PKC

uniprot E7FC99 85
type: UnificationXref
id: E7FC99
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NW21 634
organism: Gallus gallus

uniprot P49841 448
type: UnificationXref
id: P49841
db: uniprot

Glycogen synthase kinase-3
type: ProteinReference
xref: uniprot Q9U2Q9 452
organism: Caenorhabditis elegans

uniprot E1BEN9 333
type: UnificationXref
id: E1BEN9
db: uniprot

Paxillin, isoform F
type: ProteinReference
xref: uniprot Q2PDT4 198
organism: Drosophila melanogaster

uniprot F1Q2Q9 902
type: UnificationXref
id: F1Q2Q9
db: uniprot

uniprot P21804 71
type: UnificationXref
id: P21804
db: uniprot

uniprot E2RIF9 897
type: UnificationXref
id: E2RIF9
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: uniprot O70167 936
xref: PTHR10048:SF29
organism: Mus musculus

uniprot E1C3P6 1154
type: UnificationXref
id: E1C3P6
db: uniprot

uniprot F7HKP4 689
type: UnificationXref
id: F7HKP4
db: uniprot

uniprot A4IHM4 718
type: UnificationXref
id: A4IHM4
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF76
xref: uniprot A0A0G2K6Q8 316
organism: Rattus norvegicus

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F1NMJ9 76
organism: Gallus gallus

Delta-like protein
type: ProteinReference
xref: uniprot F1PNN6 726
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F6TAH0 1277
organism: Monodelphis domestica

uniprot A0A1D5NX70 317
type: UnificationXref
id: A0A1D5NX70
db: uniprot

Sphingosine kinase 2 isoform a
type: ProteinReference
xref: uniprot F6ZFF5 799
organism: Macaca mulatta

uniprot A0A1D5QE27 880
type: UnificationXref
id: A0A1D5QE27
db: uniprot

uniprot Q90Y57 756
type: UnificationXref
id: Q90Y57
db: uniprot

uniprot E2RLH2 1211
type: UnificationXref
id: E2RLH2
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: uniprot O70173 937
xref: PTHR10048:SF29
organism: Rattus norvegicus

uniprot E2RNB6 808
type: UnificationXref
id: E2RNB6
db: uniprot

STATE_TRANSITION_LEFT__Shp_2-RIGHT__Shp_2-_r224
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r224 1347
participant stoichiometry: PARTICIPANT STOICHIOMETRY r224 1348
left: Shp-2
interaction type: STATE_TRANSITION
right: Shp-2

Catenin, beta 2
type: ProteinReference
xref: uniprot E7FC99 85
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r287 1354
type: Stoichiometry
physical entity: Sck
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r287 1353
type: Stoichiometry
physical entity: Sck
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r280
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r280 1378
participant stoichiometry: PARTICIPANT STOICHIOMETRY r280 1379
left: Raf
interaction type: STATE_TRANSITION
right: Raf

uniprot Q7PM77 383
type: UnificationXref
id: Q7PM77
db: uniprot

uniprot Q9QXQ7 391
type: UnificationXref
id: Q9QXQ7
db: uniprot

Sphingosine kinase 2
type: ProteinReference
xref: uniprot A0A3Q1MBG6 798
organism: Bos taurus

uniprot F6X3B2 340
type: UnificationXref
id: F6X3B2
db: uniprot

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot F7FH70 104
organism: Ornithorhynchus anatinus

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r297
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r297 1531
participant stoichiometry: PARTICIPANT STOICHIOMETRY r297 1532
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42336 944
organism: Homo sapiens

PTHR24416:SF53
type: RelationshipXref
id: PTHR24416:SF53
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot P42338 946
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 945
organism: Mus musculus

Recombining binding protein suppressor of hairless
type: ProteinReference
xref: uniprot Q06330 852
xref: PTHR10665:SF3
organism: Homo sapiens

PTHR24416:SF52
type: RelationshipXref
id: PTHR24416:SF52
db: PANTHER Family
relationship type: By Homology

VEGF
type: ProteinReference
xref: P00241
standard name: Vascular Endothelial Growth Factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.VEGF
comment: ENTITY_REFERENCE_NOTES=Long Name: Vascular Endothelial Growth Factor Synonym: VEGF-A Accession: P00241
member entity reference: Vascular endothelial growth factor A
member entity reference: Vascular endothelial growth factor A-A

Alpha b crystallin
type: ProteinReference
xref: uniprot Q9PUR2 836
organism: Danio rerio

Frizzled-5
type: ProteinReference
xref: PTHR11309:SF136
xref: uniprot Q8CHL0 137
organism: Rattus norvegicus

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1P859 166
organism: Canis lupus familiaris

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q6PF93 957
organism: Mus musculus

Protein kinase C eta type
type: ProteinReference
xref: uniprot Q64617 624
xref: PTHR24356:SF192
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r234 1528
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r300
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r300 1427
participant stoichiometry: PARTICIPANT STOICHIOMETRY r300 1428
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

APC
type: Protein
entity reference: APC
feature: ACTIVE 25
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa10 1337
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r234 1527
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

GTPase NRas
type: ProteinReference
xref: uniprot Q95ME4 1025
xref: PTHR24070:SF189
organism: Monodelphis domestica

uniprot P54673 948
type: UnificationXref
id: P54673
db: uniprot

uniprot A0A452DI16 1074
type: UnificationXref
id: A0A452DI16
db: uniprot

uniprot D3ZTF6 891
type: UnificationXref
id: D3ZTF6
db: uniprot

uniprot E1BE66 894
type: UnificationXref
id: E1BE66
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot F6W7C8 910
organism: Macaca mulatta

Complex (Axin/APC/ GSK3beta)
type: Complex
component stoichiometry: GSK3beta s29 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Axin s27 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: APC s28 sa10 STOICHIOMETRY ID COMPLEX
component: GSK3beta
component: Axin
component: APC
feature: COMPLEX BINDING FEATURE s165 a193 1338
feature: COMPLEX BINDING FEATURE s165 a193 1334
feature: COMPLEX BINDING FEATURE s165 a193 1336
cellular location: plasma membrane

uniprot F7FWN9 53
type: UnificationXref
id: F7FWN9
db: uniprot

uniprot P41743 607
type: UnificationXref
id: P41743
db: uniprot

uniprot O35608 1134
type: UnificationXref
id: O35608
db: uniprot

uniprot P05480 58
type: UnificationXref
id: P05480
db: uniprot

uniprot Q61411 1023
type: UnificationXref
id: Q61411
db: uniprot

uniprot Q93097 386
type: UnificationXref
id: Q93097
db: uniprot

uniprot Q9VAS9 218
type: UnificationXref
id: Q9VAS9
db: uniprot

uniprot A0A2J8L0C8 807
type: UnificationXref
id: A0A2J8L0C8
db: uniprot

uniprot P19596 492
type: UnificationXref
id: P19596
db: uniprot

Proteinase-activated receptor 1
type: ProteinReference
xref: uniprot A7YY44 156
organism: Bos taurus

FAK
type: Protein
entity reference: FAK
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7CZA9 731
type: UnificationXref
id: F7CZA9
db: uniprot

STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r275
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r275 1401
participant stoichiometry: PARTICIPANT STOICHIOMETRY r275 1400
left: Ets
interaction type: STATE_TRANSITION
right: Ets

VE-PTP
type: Protein
entity reference: VE-PTP
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BBM1 913
xref: PTHR10048:SF30
organism: Monodelphis domestica

uniprot P29320 475
type: UnificationXref
id: P29320
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot D3ZRW5 330
xref: PTHR12027:SF89
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Shp_2-RIGHT__Shp_2-_r262
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r262 1453
participant stoichiometry: PARTICIPANT STOICHIOMETRY r262 1452
left: Shp-2
interaction type: STATE_TRANSITION
right: Shp-2

FRP
type: Protein
entity reference: FRP
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F1PIY7 77
organism: Canis lupus familiaris

uniprot A0A3Q1LMC7 211
type: UnificationXref
id: A0A3Q1LMC7
db: uniprot

PTHR10044:SF166
type: RelationshipXref
id: PTHR10044:SF166
db: PANTHER Family
relationship type: By Homology

Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q07960 1119
xref: PTHR45808:SF6
organism: Homo sapiens

uniprot Q8T0V8 205
type: UnificationXref
id: Q8T0V8
db: uniprot

uniprot E2RH98 334
type: UnificationXref
id: E2RH98
db: uniprot

beta catenin
type: Protein
entity reference: beta catenin
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9PUF6 797
type: UnificationXref
id: Q9PUF6
db: uniprot

uniprot Q5XIM3 1237
type: UnificationXref
id: Q5XIM3
db: uniprot

JNKK1
type: Protein
entity reference: JNKK1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Complex (Wnt/Fzd)
type: Complex
component stoichiometry: Fzd s25 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Wnt s23 sa7 STOICHIOMETRY ID COMPLEX
component: Fzd
component: Wnt
feature: COMPLEX BINDING FEATURE s163 a191 1310
feature: COMPLEX BINDING FEATURE s163 a191 1308
cellular location: plasma membrane

Sphingosine kinase 1
type: ProteinReference
xref: uniprot Q8CI15 801
organism: Mus musculus

Evidence 225
type: Evidence
evidence code: IDA
comment: SPACC Q9NP31

Evidence 222
type: Evidence
evidence code: ISS
comment: SPACC Q9NP31

Platelet-derived growth factor C
type: ProteinReference
xref: uniprot Q8CI19 697
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot F7HHY8 1096
organism: Macaca mulatta

PTHR22804:SF52
type: RelationshipXref
id: PTHR22804:SF52
db: PANTHER Family
relationship type: By Homology

Dok-R
type: Protein
entity reference: Dok-R
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GAP-RIGHT__GAP-_r247
controller: Complex (PDGFR/PDGF)

uniprot P09544 361
type: UnificationXref
id: P09544
db: uniprot

uniprot F1MBR1 810
type: UnificationXref
id: F1MBR1
db: uniprot

ncbitaxon 559292 1222
type: UnificationXref
id: 559292
db: ncbitaxon

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot A0A2I3S045 715
organism: Pan troglodytes

uniprot Q92048 384
type: UnificationXref
id: Q92048
db: uniprot

uniprot P85299 1118
type: UnificationXref
id: P85299
db: uniprot

PARTICIPANT STOICHIOMETRY r253 1478
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r253 1477
type: Stoichiometry
physical entity: STAT1
stoichiometric coefficient: 1.0

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F6QUW1 168
organism: Monodelphis domestica

ncbitaxon 5786 995
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot K7BNT4 306
type: UnificationXref
id: K7BNT4
db: uniprot

Rac
type: Protein
entity reference: Rac
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q0V7L8 749
type: UnificationXref
id: Q0V7L8
db: uniprot

Receptor-type tyrosine-protein phosphatase beta
type: ProteinReference
xref: uniprot P23467 1179
xref: PTHR46957:SF2
organism: Homo sapiens

uniprot A0A0R4IY09 652
type: UnificationXref
id: A0A0R4IY09
db: uniprot

Phospholipase A2
type: ProteinReference
evidence: Evidence 766
xref: uniprot F6UQ33 768
xref: PTHR10728:SF13
organism: Canis lupus familiaris

PTHR45807:SF5
type: RelationshipXref
id: PTHR45807:SF5
db: PANTHER Family
relationship type: By Homology

APC
type: ProteinReference
xref: P00195
standard name: Adenomatous Polyposis of the Colon
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Adenomatous Polyposis of the Colon Synonym: FAP,FPC,Familial Adenomatous Polyposis,Familial Polyposis of the Colon Accession: P00195
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.APC
member entity reference: Adenomatous polyposis coli protein 2
member entity reference: Uncharacterized protein
member entity reference: APC, WNT signaling pathway regulator
member entity reference: APC-like, isoform A
member entity reference: Adenomatous polyposis coli protein
member entity reference: Adenomatous polyposis coli
member entity reference: APC2, WNT-signaling pathway regulator
member entity reference: Adenomatous polyposis coli 2

uniprot P05622 790
type: UnificationXref
id: P05622
db: uniprot

STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r234
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r234 1528
participant stoichiometry: PARTICIPANT STOICHIOMETRY r234 1527
left: Ets
interaction type: STATE_TRANSITION
right: Ets

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot O93599 529
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r262 1453
type: Stoichiometry
physical entity: Shp-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r262 1452
type: Stoichiometry
physical entity: Shp-2
stoichiometric coefficient: 1.0

Recombining binding protein suppressor of hairless-like protein
type: ProteinReference
xref: uniprot Q9UBG7 854
organism: Homo sapiens

uniprot P54763 480
type: UnificationXref
id: P54763
db: uniprot

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

uniprot F7HAF3 771
type: UnificationXref
id: F7HAF3
db: uniprot

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P40763 530
organism: Homo sapiens

uniprot D4A3M8 505
type: UnificationXref
id: D4A3M8
db: uniprot

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot P23458 82
organism: Homo sapiens

Protein jagged-1
type: ProteinReference
xref: PTHR24044:SF448
xref: uniprot P78504 745
organism: Homo sapiens

STATE_TRANSITION_LEFT__Grb14-RIGHT__Grb14-_r268
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r268 1440
participant stoichiometry: PARTICIPANT STOICHIOMETRY r268 1441
left: Grb14
interaction type: STATE_TRANSITION
right: Grb14

uniprot P15655 491
type: UnificationXref
id: P15655
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot K7CZM1 174
organism: Pan troglodytes

Ephrin type-B receptor 1
type: ProteinReference
xref: uniprot P09759 472
organism: Rattus norvegicus

Fibroblast growth factor receptor
type: ProteinReference
xref: PTHR24416:SF131
xref: uniprot Q28J96 73
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r301
controller: PI3K

uniprot Q2XPT7 639
type: UnificationXref
id: Q2XPT7
db: uniprot

PLA2
type: Protein
entity reference: PLA2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Platelet-derived growth factor receptor beta
type: ProteinReference
xref: uniprot F7BTH1 789
xref: PTHR24416:SF53
organism: Macaca mulatta

CTNNB1 isoform 2
type: ProteinReference
xref: uniprot H2R2U1 90
xref: PTHR45976:SF4
organism: Pan troglodytes

Baculoviral IAP repeat-containing protein 5
type: ProteinReference
xref: uniprot O15392 233
organism: Homo sapiens

FAK
type: ProteinReference
xref: P00209
standard name: Focal Adhesion Kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.FAK
comment: ENTITY_REFERENCE_NOTES=Long Name: Focal Adhesion Kinase Synonym: Cytoplasmic Protein-Tyrosine Kinase,FAK1,Focal Adhesion Kinase 1,PTK2 Accession: P00209
member entity reference: Protein tyrosine kinase 2
member entity reference: Inactive tyrosine-protein kinase kin-32
member entity reference: Focal adhesion kinase 1
member entity reference: Protein CBR-KIN-32
member entity reference: Protein tyrosine kinase 2ab

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E823 285
xref: PTHR24055:SF203
organism: Monodelphis domestica

cPLA2
type: Protein
entity reference: cPLA2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q99PD6 208
type: UnificationXref
id: Q99PD6
db: uniprot

uniprot P46108 403
type: UnificationXref
id: P46108
db: uniprot

STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r231
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r231 1538
participant stoichiometry: PARTICIPANT STOICHIOMETRY r231 1537
left: Raf
interaction type: STATE_TRANSITION
right: Raf

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF421
xref: uniprot F1NMD6 725
organism: Gallus gallus

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot A0A2I3TK00 1072
organism: Pan troglodytes

uniprot F1N6L8 337
type: UnificationXref
id: F1N6L8
db: uniprot

uniprot P23467 1179
type: UnificationXref
id: P23467
db: uniprot

uniprot F1Q4F8 658
type: UnificationXref
id: F1Q4F8
db: uniprot

uniprot Q13177 1171
type: UnificationXref
id: Q13177
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 32

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q08BT6 617
xref: PTHR24356:SF159
organism: Xenopus tropicalis

uniprot Q28J96 73
type: UnificationXref
id: Q28J96
db: uniprot

uniprot K7ALD7 1006
type: UnificationXref
id: K7ALD7
db: uniprot

uniprot Q503B6 1021
type: UnificationXref
id: Q503B6
db: uniprot

uniprot Q64617 624
type: UnificationXref
id: Q64617
db: uniprot

uniprot Q8CBF3 483
type: UnificationXref
id: Q8CBF3
db: uniprot

uniprot Q86XP0 1187
type: UnificationXref
id: Q86XP0
db: uniprot

uniprot O57409 739
type: UnificationXref
id: O57409
db: uniprot

uniprot F6QDY0 767
type: UnificationXref
id: F6QDY0
db: uniprot

uniprot A7STP5 988
type: UnificationXref
id: A7STP5
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F6WR53 50
xref: PTHR24418:SF53
organism: Monodelphis domestica

uniprot Q8C180 1056
type: UnificationXref
id: Q8C180
db: uniprot

uniprot A0A0B4KHC3 546
type: UnificationXref
id: A0A0B4KHC3
db: uniprot

uniprot P05771 594
type: UnificationXref
id: P05771
db: uniprot

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: uniprot P62745 1227
xref: PTHR24072:SF0
organism: Homo sapiens

uniprot O55033 514
type: UnificationXref
id: O55033
db: uniprot

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot P62747 1229
organism: Rattus norvegicus

uniprot B6V8E6 84
type: UnificationXref
id: B6V8E6
db: uniprot

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: uniprot P62746 1228
xref: PTHR24072:SF0
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 286
organism: Xenopus tropicalis

uniprot Q92765 981
type: UnificationXref
id: Q92765
db: uniprot

uniprot D4A229 554
type: UnificationXref
id: D4A229
db: uniprot

uniprot F1P8U6 1145
type: UnificationXref
id: F1P8U6
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P68404 610
organism: Mus musculus

uniprot P31751 668
type: UnificationXref
id: P31751
db: uniprot

uniprot A0A2I3SHP7 1272
type: UnificationXref
id: A0A2I3SHP7
db: uniprot

uniprot P23928 825
type: UnificationXref
id: P23928
db: uniprot

uniprot F7CS91 1213
type: UnificationXref
id: F7CS91
db: uniprot

uniprot A0A1D5QUZ8 281
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

uniprot D3ZHH1 719
type: UnificationXref
id: D3ZHH1
db: uniprot

uniprot Q13233 418
type: UnificationXref
id: Q13233
db: uniprot

uniprot Q6DI48 752
type: UnificationXref
id: Q6DI48
db: uniprot

STAT3
type: ProteinReference
xref: P00217
standard name: Signal transducers and activators of transcription 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.STAT3
comment: ENTITY_REFERENCE_NOTES=Long Name: Signal Transducer and Activator of Transcription 3 Synonym: APRF,Acute-Phase Response Factor Accession: P00217
member entity reference: Signal transducer and activator of transcription
member entity reference: Signal transducer and activator of transcription 3

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot P70618 34
organism: Rattus norvegicus

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot E1BWA3 558
type: UnificationXref
id: E1BWA3
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7DVL1 576
xref: PTHR24356:SF214
organism: Xenopus tropicalis

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot H2QAS6 583
organism: Pan troglodytes

Protein Wnt
type: ProteinReference
xref: uniprot E1BEN9 333
xref: PTHR12027:SF91
organism: Bos taurus

Tyrosine-protein kinase receptor Tie-2
type: ProteinReference
xref: uniprot O73791 1147
organism: Danio rerio

Sck
type: Protein
entity reference: Sck
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot E2RSH8 49
organism: Canis lupus familiaris

uniprot P01127 691
type: UnificationXref
id: P01127
db: uniprot

uniprot F7F3F4 1139
type: UnificationXref
id: F7F3F4
db: uniprot

uniprot O46404 935
type: UnificationXref
id: O46404
db: uniprot

uniprot P52799 1039
type: UnificationXref
id: P52799
db: uniprot

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: PTHR21258:SF40
xref: uniprot Q8WU20 1057
organism: Homo sapiens

TCF
type: Protein
entity reference: TCF
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q0VCX4 94
type: UnificationXref
id: Q0VCX4
db: uniprot

MEKK1
type: Protein
entity reference: MEKK1
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot O75914 1166
organism: Homo sapiens

uniprot Q8AXB3 640
type: UnificationXref
id: Q8AXB3
db: uniprot

uniprot P18266 447
type: UnificationXref
id: P18266
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47196 669
xref: PTHR24356:SF171
organism: Rattus norvegicus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47197 670
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q9TXI7 967
organism: Caenorhabditis elegans

uniprot F6Z879 242
type: UnificationXref
id: F6Z879
db: uniprot

uniprot H2QSZ7 1053
type: UnificationXref
id: H2QSZ7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r181
controller: Ras

uniprot P48800 494
type: UnificationXref
id: P48800
db: uniprot

uniprot Q61086 136
type: UnificationXref
id: Q61086
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r290
controller: Complex (VEGFR-2/VEGF)

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot Q7YQL4 1176
organism: Pan troglodytes

Erk
type: ProteinReference
xref: P00203
standard name: Extracellular regulated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Extracellular regulated kinase Synonym: JNK-Activated Kinase1,JNKK1,MAP2K4,MAPK/ERK Kinase 4,MAPKK4,MEK4,MKK4,Mitogen-Activated ProteinKinase Kinase 4,PRKMK4,Protein Kinase, Mitogen-Activated, Kinase 4,SAPK/ERK Kinase 1,SEK1,SERK1 Accession: P00203
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Erk
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase (Fragment)

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

Docking protein 1
type: ProteinReference
xref: uniprot Q4QQV2 21
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: uniprot J9P5H0 353
xref: PTHR12027:SF33
organism: Canis lupus familiaris

Transcription factor 7
type: ProteinReference
xref: uniprot P36402 1063
organism: Homo sapiens

GRB14 isoform 2
type: ProteinReference
xref: uniprot H2QIW7 228
xref: PTHR11243:SF22
organism: Pan troglodytes

SPK
type: Protein
entity reference: SPK
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

FAK
type: Protein
entity reference: FAK
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

TF
type: ProteinReference
xref: P00191
standard name: Tissue Factor
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.TF
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Tissue Factor Synonym: Coagulation Factor III,F3,Tissue Thromboplastin Accession: P00191
member entity reference: Tissue factor

STATE_TRANSITION_LEFT__PLC_gamma-RIGHT__PLC_gamma-_r203
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r203 1439
participant stoichiometry: PARTICIPANT STOICHIOMETRY r203 1438
left: PLC-gamma
interaction type: STATE_TRANSITION
right: PLC-gamma

uniprot F1NJK2 498
type: UnificationXref
id: F1NJK2
db: uniprot

Cytosolic phospholipase A2 delta
type: ProteinReference
xref: uniprot Q86XP0 1187
organism: Homo sapiens

ncbitaxon 9606 15
type: UnificationXref
id: 9606
db: ncbitaxon

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F6Z5N3 1002
organism: Monodelphis domestica

uniprot F7BVQ1 1278
type: UnificationXref
id: F7BVQ1
db: uniprot

uniprot Q02384 176
type: UnificationXref
id: Q02384
db: uniprot

AGAP011890-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PZG1 1106
organism: Anopheles gambiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GRB2-RIGHT__GRB2-_r225
controller: Shp-2

MEK
type: Protein
entity reference: MEK
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

c-Fos
type: Protein
entity reference: c-Fos
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa4 1325
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A4D7S0 323
type: UnificationXref
id: A4D7S0
db: uniprot

uniprot H2R8U9 172
type: UnificationXref
id: H2R8U9
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot P48736 947
organism: Homo sapiens

c-Jun
type: Protein
entity reference: c-Jun
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa3 1323
feature: ACTIVE 25
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7719 272
type: UnificationXref
id: 7719
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__VRAP-RIGHT__VRAP-_r286
controller: Complex (VEGFR-2/VEGF)

uniprot Q99466 1268
type: UnificationXref
id: Q99466
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05412 542
organism: Homo sapiens

uniprot H2QC24 258
type: UnificationXref
id: H2QC24
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P27986 942
organism: Homo sapiens

Tie2
type: ProteinReference
xref: P00247
standard name: Tie-2
comment: ENTITY_REFERENCE_NOTES=Long Name: Tie-2 Synonym: TEK,TEK Tyrosine Kinase Accession: P00247
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.RECEPTOR.Tie2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Angiopoietin-1 receptor
member entity reference: TEK isoform 2
member entity reference: TEK receptor tyrosine kinase
member entity reference: Tyrosine-protein kinase receptor Tie-2
member entity reference: Uncharacterized protein
member entity reference: Endothelial-specific receptor tyrosine kinase

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot H9FYU7 173
organism: Macaca mulatta

APC
type: Protein
entity reference: APC
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

V-crk avian sarcoma virus CT10 oncogene homolog
type: ProteinReference
xref: uniprot F6XER9 399
xref: PTHR19969:SF8
organism: Xenopus tropicalis

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot E9QAN8 899
organism: Mus musculus

PTHR14388:SF9
type: RelationshipXref
id: PTHR14388:SF9
db: PANTHER Family
relationship type: By Homology

uniprot F6RA79 570
type: UnificationXref
id: F6RA79
db: uniprot

PTHR10337:SF2
type: RelationshipXref
id: PTHR10337:SF2
db: PANTHER Family
relationship type: By Homology

uniprot H2R8K0 223
type: UnificationXref
id: H2R8K0
db: uniprot

Complex (eNOS/Ca2+
type: Complex
component stoichiometry: eNOS s208 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s209 sa19 STOICHIOMETRY ID COMPLEX
component: Ca2+
component: eNOS
feature: COMPLEX BINDING FEATURE s207 a299 1326
feature: COMPLEX BINDING FEATURE s207 a299 1328
cellular location: plasma membrane

EPH receptor B3
type: ProteinReference
xref: PTHR24416:SF120
xref: uniprot F1ML02 461
organism: Bos taurus

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot P52332 83
organism: Mus musculus

PTHR10337:SF5
type: RelationshipXref
id: PTHR10337:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q6PH06 410
type: UnificationXref
id: Q6PH06
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7FHD1 288
organism: Monodelphis domestica

Adenomatous polyposis coli protein
type: ProteinReference
xref: uniprot Q61315 217
xref: PTHR12607:SF11
organism: Mus musculus

Complex (VEGFR-2/VEGF)
type: Complex
component stoichiometry: VEGFR 2 s56 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: VEGF s57 sa25 STOICHIOMETRY ID COMPLEX
component: VEGFR-2
component: VEGF
feature: COMPLEX BINDING FEATURE s206 a290 1320
feature: COMPLEX BINDING FEATURE s206 a290 1318
cellular location: plasma membrane

uniprot H2RAM0 351
type: UnificationXref
id: H2RAM0
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: uniprot O00443 930
xref: PTHR10048:SF28
organism: Homo sapiens

uniprot Q92997 270
type: UnificationXref
id: Q92997
db: uniprot

uniprot F7GEK1 664
type: UnificationXref
id: F7GEK1
db: uniprot

uniprot O35904 934
type: UnificationXref
id: O35904
db: uniprot

uniprot A0A2J8N8E6 108
type: UnificationXref
id: A0A2J8N8E6
db: uniprot

PARTICIPANT STOICHIOMETRY r259 1461
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r259 1460
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

uniprot Q07960 1119
type: UnificationXref
id: Q07960
db: uniprot

RAS p21 protein activator (GTPase activating protein) 1
type: ProteinReference
xref: uniprot H2QR74 146
xref: PTHR10194:SF19
organism: Pan troglodytes

Platelet-derived growth factor subunit B
type: ProteinReference
xref: uniprot Q6Q7I7 696
organism: Canis lupus familiaris

INHIBITION
type: Control
xref: INHIBITION
control type: INHIBITION
controller: Dsh

Angiopoietin 1
type: ProteinReference
xref: PTHR19143:SF156
xref: uniprot F7E6U7 1138
organism: Monodelphis domestica

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot A0A2I3SXI2 440
organism: Pan troglodytes

uniprot P03967 1009
type: UnificationXref
id: P03967
db: uniprot

PI-3 kinase
type: ProteinReference
xref: uniprot P91634 952
organism: Drosophila melanogaster

uniprot F7F5X1 1004
type: UnificationXref
id: F7F5X1
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 15

uniprot Q9JLM9 231
type: UnificationXref
id: Q9JLM9
db: uniprot

PTHR23043:SF7
type: RelationshipXref
id: PTHR23043:SF7
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Nck-RIGHT__Nck-_r270
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r270 1416
participant stoichiometry: PARTICIPANT STOICHIOMETRY r270 1417
left: Nck
interaction type: STATE_TRANSITION
right: Nck

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O00459 931
organism: Homo sapiens

Ephrin type-B receptor 1 (Fragment)
type: ProteinReference
xref: uniprot Q07494 481
organism: Gallus gallus

Ephrin type-B receptor 3 (Fragment)
type: ProteinReference
xref: uniprot Q07498 482
organism: Gallus gallus

Paxillin
type: ProteinReference
xref: uniprot Q66H76 203
xref: PTHR24216:SF11
organism: Rattus norvegicus

Angiopoietin-1 receptor
type: ProteinReference
xref: PTHR24416:SF125
xref: uniprot Q06807 1150
organism: Bos taurus

PTHR24072:SF153
type: RelationshipXref
id: PTHR24072:SF153
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r220 1363
type: Stoichiometry
physical entity: Src
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r220 1364
type: Stoichiometry
physical entity: Src
stoichiometric coefficient: 1.0

uniprot Q9YGX6 393
type: UnificationXref
id: Q9YGX6
db: uniprot

Nuclear receptor subfamily 1 group I member 2
type: ProteinReference
xref: uniprot Q8SQ01 161
organism: Macaca mulatta

ncbitaxon 7668 98
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot H2QVU0 13
type: UnificationXref
id: H2QVU0
db: uniprot

uniprot E9QAN8 899
type: UnificationXref
id: E9QAN8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Nck-RIGHT__Nck-_r270
controller: Dok-R

p38MAPK
type: Protein
entity reference: p38MAPK
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot F7E738 345
organism: Macaca mulatta

uniprot P28028 1087
type: UnificationXref
id: P28028
db: uniprot

uniprot A0A2I3T7A8 884
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: uniprot Q9PUF6 797
organism: Gallus gallus

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: uniprot Q66H84 1105
xref: PTHR24349:SF64
organism: Rattus norvegicus

uniprot P47941 405
type: UnificationXref
id: P47941
db: uniprot

Wnt
type: ProteinReference
xref: P00206
standard name: Wingless-type MMTV integration site family member
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Wingless-Type MMTV Integration Site Family Synonym: Wnt Accession: P00206
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Wnt
member entity reference: Protein Wnt
member entity reference: Protein Wnt-2
member entity reference: Protein Wnt-5b
member entity reference: Proto-oncogene Wnt-1
member entity reference: Protein wingless
member entity reference: Protein Wnt-7b
member entity reference: Protein Wnt-2b
member entity reference: Protein Wnt-5a
member entity reference: Protein Wnt-7a
member entity reference: Protein Wnt-10a
member entity reference: Protein CBR-CWN-2
member entity reference: Protein Wnt-10b
member entity reference: Protein Wnt-1
member entity reference: Protein Wnt-5

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MSZ4 247
xref: PTHR10878:SF8
organism: Bos taurus

uniprot V6CLJ5 855
type: UnificationXref
id: V6CLJ5
db: uniprot

uniprot P51136 449
type: UnificationXref
id: P51136
db: uniprot

STATE_TRANSITION_LEFT__PLC_gamma-RIGHT__PLC_gamma-_r285
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r285 1361
participant stoichiometry: PARTICIPANT STOICHIOMETRY r285 1362
left: PLC-gamma
interaction type: STATE_TRANSITION
right: PLC-gamma

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r250
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r250 1487
participant stoichiometry: PARTICIPANT STOICHIOMETRY r250 1488
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6V332 28
organism: Macaca mulatta

Frizzled class receptor 2
type: ProteinReference
xref: uniprot F1QBI2 116
xref: PTHR11309:SF34
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS_-_cPLA2-RIGHT__Complex__cPLA2_endsub_Ca2_PLUS__endsuper_-_r277
controller: Erk

uniprot J9P2Q5 352
type: UnificationXref
id: J9P2Q5
db: uniprot

STATE_TRANSITION_LEFT__GTPase-RIGHT__GTPase-_r156
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r156 1485
participant stoichiometry: PARTICIPANT STOICHIOMETRY r156 1486
left: GTPase
interaction type: STATE_TRANSITION
right: GTPase

uniprot F7BBM1 913
type: UnificationXref
id: F7BBM1
db: uniprot

uniprot Q9TXI7 967
type: UnificationXref
id: Q9TXI7
db: uniprot

uniprot P48736 947
type: UnificationXref
id: P48736
db: uniprot

uniprot P70496 308
type: UnificationXref
id: P70496
db: uniprot

YALI0D01045p
type: ProteinReference
xref: uniprot Q6CAP4 1241
organism: Yarrowia lipolytica

PARTICIPANT STOICHIOMETRY r278 1393
type: Stoichiometry
physical entity: Erk
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r278 1394
type: Stoichiometry
physical entity: Erk
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r175 1418
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r175 1419
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

uniprot D4A6C5 1110
type: UnificationXref
id: D4A6C5
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q1LZB2 516
type: UnificationXref
id: Q1LZB2
db: uniprot

FZD5 isoform 1
type: ProteinReference
xref: uniprot H2QJA9 127
xref: PTHR11309:SF136
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot F6Y8U0 1192
organism: Macaca mulatta

uniprot P35968 638
type: UnificationXref
id: P35968
db: uniprot

Protein tyrosine kinase 2
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot A0A3Q1N508 422
organism: Bos taurus

Protein Wnt
type: ProteinReference
xref: uniprot F6X3B2 340
xref: PTHR12027:SF91
organism: Xenopus tropicalis

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q9QUI0 1253
organism: Mus musculus

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 984

Frizzled
type: ProteinReference
xref: uniprot P18537 131
organism: Drosophila melanogaster

uniprot E2QV83 843
type: UnificationXref
id: E2QV83
db: uniprot

uniprot O12990 81
type: UnificationXref
id: O12990
db: uniprot

Phosphatidylinositol 3-kinase VPS34-like
type: ProteinReference
xref: uniprot P54676 951
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 3
type: ProteinReference
xref: uniprot P54675 950
organism: Dictyostelium discoideum

uniprot Q8UWJ4 754
type: UnificationXref
id: Q8UWJ4
db: uniprot

Phosphatidylinositol 3-kinase 2
type: ProteinReference
xref: uniprot P54674 949
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 1
type: ProteinReference
xref: uniprot P54673 948
organism: Dictyostelium discoideum

uniprot H2QFS6 926
type: UnificationXref
id: H2QFS6
db: uniprot

uniprot F7E738 345
type: UnificationXref
id: F7E738
db: uniprot

uniprot Q9NQB0 1065
type: UnificationXref
id: Q9NQB0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P10686 1281
organism: Rattus norvegicus

Protein Wnt-7b
type: ProteinReference
xref: PTHR12027:SF73
xref: uniprot P28047 368
organism: Mus musculus

ncbitaxon 9031 55
type: UnificationXref
id: 9031
db: ncbitaxon

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F6YLX1 78
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r154 1492
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

uniprot H2PXY8 924
type: UnificationXref
id: H2PXY8
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF76
xref: uniprot A0A1D5RE70 320
organism: Macaca mulatta

uniprot F6VXG1 909
type: UnificationXref
id: F6VXG1
db: uniprot

PARTICIPANT STOICHIOMETRY r154 1493
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

uniprot F6SW23 905
type: UnificationXref
id: F6SW23
db: uniprot

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r260
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r260 1458
participant stoichiometry: PARTICIPANT STOICHIOMETRY r260 1459
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

Fibroblast growth factor 2
type: ProteinReference
xref: uniprot P48798 493
organism: Monodelphis domestica

uniprot F6RCU6 662
type: UnificationXref
id: F6RCU6
db: uniprot

Ephrin-B2
type: ProteinReference
xref: uniprot Q9PUJ4 1043
organism: Gallus gallus

Delta-like protein
type: ProteinReference
xref: uniprot A0A2J8JA34 716
organism: Pan troglodytes

uniprot E1BS97 1153
type: UnificationXref
id: E1BS97
db: uniprot

PI3K
type: ProteinReference
xref: P00236
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.PI3K
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphatidylinositol 3-Kinase Synonym: PI(3)K Accession: P00236
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 3-kinase 3
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit gamma
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha
member entity reference: AGAP011036-PA (Fragment)
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
member entity reference: PIK3CG isoform 1
member entity reference: PIK3C2A isoform 5
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
member entity reference: Pi3K21B, isoform B
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
member entity reference: Phosphatidylinositol 3-kinase piki-1
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphoinositide-3-kinase regulatory subunit 3
member entity reference: Phosphoinositide-3-kinase regulatory subunit 2
member entity reference: PI-3 kinase
member entity reference: AGAP000018-PA
member entity reference: Phosphatidylinositol 3-kinase 1
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit beta
member entity reference: Phosphatidylinositol 3-kinase 2
member entity reference: Phosphoinositide-3-kinase regulatory subunit 1
member entity reference: LD28067p

Pi3K21B, isoform B
type: ProteinReference
xref: PTHR10155:SF10
xref: uniprot Q7KTZ2 959
organism: Drosophila melanogaster

uniprot F7FGD2 577
type: UnificationXref
id: F7FGD2
db: uniprot

uniprot O35346 427
type: UnificationXref
id: O35346
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QJY6 881
xref: PTHR10048:SF28
organism: Macaca mulatta

Neuronal proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot P05480 58
organism: Mus musculus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot H9EU39 586
organism: Macaca mulatta

Wnt
type: Protein
entity reference: Wnt
comment: SPECIES_TYPE=PROTEIN

uniprot Q9DGD9 651
type: UnificationXref
id: Q9DGD9
db: uniprot

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot Q05713 829
organism: Gallus gallus

uniprot F6RNC2 971
type: UnificationXref
id: F6RNC2
db: uniprot

uniprot Q6P943 538
type: UnificationXref
id: Q6P943
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PAR-RIGHT__PAR-_r147
controller: TF

nuclear membrane
type: CellularLocationVocabulary
xref: GO GO:0031965 3

uniprot Q4KM68 862
type: UnificationXref
id: Q4KM68
db: uniprot

uniprot Q54NW4 200
type: UnificationXref
id: Q54NW4
db: uniprot

Secreted frizzled-related protein 1
type: ProteinReference
xref: uniprot Q9DEQ4 983
xref: PTHR11309:SF87
organism: Gallus gallus

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot P28028 1087
organism: Mus musculus

SHC-transforming protein 2
type: ProteinReference
xref: uniprot P98077 279
xref: PTHR10337:SF5
organism: Homo sapiens

Delta-like protein
type: ProteinReference
xref: uniprot F7ENN2 732
xref: PTHR24044:SF448
organism: Xenopus tropicalis

APC-like, isoform A
type: ProteinReference
xref: uniprot Q9VAS9 218
organism: Drosophila melanogaster

uniprot Q4QQV2 21
type: UnificationXref
id: Q4QQV2
db: uniprot

uniprot O57328 128
type: UnificationXref
id: O57328
db: uniprot

Protein C-ets-1
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot P41156 107
organism: Rattus norvegicus

uniprot F1MMW6 253
type: UnificationXref
id: F1MMW6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F7BAS2 1161
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: PTHR10665:SF3
xref: uniprot F6YB95 845
organism: Monodelphis domestica

uniprot F6UM70 464
type: UnificationXref
id: F6UM70
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E9I1I7 992
organism: Daphnia pulex

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot Q8CIH5 1286
xref: PTHR10336:SF25
organism: Mus musculus

PTHR24072:SF100
type: RelationshipXref
id: PTHR24072:SF100
db: PANTHER Family
relationship type: By Homology

Ephrin-B2b
type: ProteinReference
xref: uniprot Q90Z32 1042
organism: Danio rerio

p38MAPK
type: Protein
entity reference: p38MAPK
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Candida albicans
type: BioSource
xref: ncbitaxon 237561 1218

Protein delta homolog 1
type: ProteinReference
xref: uniprot P80370 746
organism: Homo sapiens

uniprot E1BTW5 721
type: UnificationXref
id: E1BTW5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_Jun-RIGHT__c_Jun-_r154
controller: JNK1

Ras homolog family member C
type: ProteinReference
xref: uniprot A0A0G2K6E0 1203
xref: PTHR24072:SF100
organism: Rattus norvegicus

SHC-transforming protein 1
type: ProteinReference
xref: uniprot P98083 44
xref: PTHR10337:SF2
organism: Mus musculus

uniprot P28867 604
type: UnificationXref
id: P28867
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot E2RJX4 655
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r249 1500
type: Stoichiometry
physical entity: c-Fos
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r249 1501
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r249 1502
type: Stoichiometry
physical entity: Complex (c-Jun/c-Fos)
stoichiometric coefficient: 1.0

uniprot O76808 849
type: UnificationXref
id: O76808
db: uniprot

uniprot P70375 277
type: UnificationXref
id: P70375
db: uniprot

Dishevelled segment polarity protein 3
type: ProteinReference
xref: uniprot F1PIB1 254
xref: PTHR10878:SF6
organism: Canis lupus familiaris

VEGFR-2
type: Protein
entity reference: VEGFR-2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Axin 1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot F6XWP7 1191
organism: Xenopus tropicalis

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 151

uniprot Q61221 504
type: UnificationXref
id: Q61221
db: uniprot

Fibroblast growth factor receptor 1-A
type: ProteinReference
xref: uniprot Q90Z00 74
organism: Danio rerio

Protein Wnt
type: ProteinReference
xref: uniprot H2QJF8 350
xref: PTHR12027:SF89
organism: Pan troglodytes

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q04759 614
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: uniprot A0A3Q1MSP9 550
xref: PTHR24356:SF170
organism: Bos taurus

uniprot H9EPM1 446
type: UnificationXref
id: H9EPM1
db: uniprot

uniprot Q9WV60 453
type: UnificationXref
id: Q9WV60
db: uniprot

Catenin beta-1
type: ProteinReference
xref: uniprot Q0VCX4 94
xref: PTHR45976:SF4
organism: Bos taurus

APC, WNT signaling pathway regulator
type: ProteinReference
xref: PTHR12607:SF11
xref: uniprot H2QRB5 213
organism: Pan troglodytes

PTHR11633:SF4
type: RelationshipXref
id: PTHR11633:SF4
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R589 210
xref: PTHR12607:SF3
organism: Macaca mulatta

PTHR11633:SF3
type: RelationshipXref
id: PTHR11633:SF3
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
evidence: Evidence 222
xref: PTHR14388:SF9
xref: uniprot A0A1D5QZZ0 221
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VW12 1146
xref: PTHR24416:SF125
organism: Macaca mulatta

Platelet-derived growth factor subunit A
type: ProteinReference
xref: uniprot F6WRD7 687
organism: Xenopus tropicalis

uniprot P85298 1117
type: UnificationXref
id: P85298
db: uniprot

ncbitaxon 237561 1218
type: UnificationXref
id: 237561
db: ncbitaxon

EPH receptor A3
type: ProteinReference
xref: uniprot F7EX10 468
organism: Ornithorhynchus anatinus

uniprot Q15139 618
type: UnificationXref
id: Q15139
db: uniprot

uniprot F1NCY7 1092
type: UnificationXref
id: F1NCY7
db: uniprot

PARTICIPANT STOICHIOMETRY r140 1520
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r140 1521
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

uniprot A0A1D5R9X3 534
type: UnificationXref
id: A0A1D5R9X3
db: uniprot

uniprot A0A8J8 1127
type: UnificationXref
id: A0A8J8
db: uniprot

Phospholipase A2
type: ProteinReference
evidence: Evidence 766
xref: PTHR10728:SF13
xref: uniprot H2Q0T0 772
organism: Pan troglodytes

Protein Wnt-5b
type: ProteinReference
xref: PTHR12027:SF87
xref: uniprot P22726 365
organism: Mus musculus

Protein Wnt-5a
type: ProteinReference
xref: uniprot P22725 364
xref: PTHR12027:SF33
organism: Mus musculus

VE-PTP
type: ProteinReference
xref: P00250
standard name: Vascular Endothelial Protein Tyrosine Phosphatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Vascular Endothelial Protein Tyrosine Phosphatase Synonym: PTPRB,Protein-Tyrosine Phosphatase, Receptor-Type, Beta Accession: P00250
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.VE-PTP
member entity reference: Receptor-type tyrosine-protein phosphatase beta
member entity reference: Uncharacterized protein

uniprot F7ATA8 813
type: UnificationXref
id: F7ATA8
db: uniprot

Axin 2
type: ProteinReference
xref: PTHR46102:SF1
xref: uniprot E2R9F8 1190
organism: Canis lupus familiaris

uniprot P04627 1080
type: UnificationXref
id: P04627
db: uniprot

Dishevelled segment polarity protein 2
type: ProteinReference
xref: uniprot F7BUW7 256
xref: PTHR10878:SF8
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__STAT3-RIGHT__STAT3-_r177
controller: JAK1

uniprot Q9NPG1 140
type: UnificationXref
id: Q9NPG1
db: uniprot

uniprot P54753 477
type: UnificationXref
id: P54753
db: uniprot

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot Q64303 1175
organism: Rattus norvegicus

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: uniprot F1Q2Q9 902
xref: PTHR10155:SF3
organism: Canis lupus familiaris

Ephrin B2
type: ProteinReference
xref: uniprot F1Q2Q5 1031
xref: PTHR11304:SF18
organism: Canis lupus familiaris

uniprot P46531 1264
type: UnificationXref
id: P46531
db: uniprot

uniprot H2RDK4 1260
type: UnificationXref
id: H2RDK4
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot A8WR64 553
organism: Caenorhabditis briggsae

MAPKAPK2/3
type: Protein
entity reference: MAPKAPK2/3
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

EPH receptor B3
type: ProteinReference
xref: uniprot F7CRM0 465
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Erk-RIGHT__Erk-_r183
controller: MEK

uniprot O93468 1220
type: UnificationXref
id: O93468
db: uniprot

V-fos FBJ murine osteosarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot Q6P0S4 877
organism: Danio rerio

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q7QK56 673
organism: Anopheles gambiae

uniprot Q8VI36 206
type: UnificationXref
id: Q8VI36
db: uniprot

uniprot B5DE89 1047
type: UnificationXref
id: B5DE89
db: uniprot

Dsh
type: Protein
entity reference: Dsh
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein kinase C-like 3
type: ProteinReference
xref: uniprot Q19266 619
organism: Caenorhabditis elegans

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot A0A2I3T9Y4 653
organism: Pan troglodytes

Coagulation factor VII
type: ProteinReference
xref: PTHR24278:SF26
xref: uniprot Q2F9P2 278
organism: Pan troglodytes

SHC
type: ProteinReference
xref: P00183
standard name: SH2 homology domain containing transforming protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.SHC
comment: ENTITY_REFERENCE_NOTES=Long Name: Src Homology Domain Containing Protein Synonym: SHC Transforming Protein Accession: P00183
member entity reference: Uncharacterized protein
member entity reference: SHC (Src homology 2 domain containing) transforming protein 1
member entity reference: SHC-transforming protein 1

Protein Wnt-7b
type: ProteinReference
xref: PTHR12027:SF73
xref: uniprot Q3L254 380
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS_-_eNOS-RIGHT__Complex__eNOS_Ca2_PLUS_-_r295
controller: Akt

uniprot Q7PVR1 298
type: UnificationXref
id: Q7PVR1
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re107
control type: ACTIVATION
controller: Akt

uniprot F1MBA2 227
type: UnificationXref
id: F1MBA2
db: uniprot

Ephrin-B1
type: ProteinReference
xref: uniprot F7B9D9 1032
organism: Xenopus tropicalis

uniprot P35918 637
type: UnificationXref
id: P35918
db: uniprot

uniprot F1N8W8 1157
type: UnificationXref
id: F1N8W8
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot O77628 873
organism: Bos taurus

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot P08134 1223
organism: Homo sapiens

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot O77627 541
organism: Bos taurus

Protein Wnt
type: ProteinReference
xref: uniprot E1BDG5 332
xref: PTHR12027:SF33
organism: Bos taurus

STATE_TRANSITION_LEFT__FRS_2-RIGHT__FRS_2-_r223
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r223 1351
participant stoichiometry: PARTICIPANT STOICHIOMETRY r223 1352
left: FRS-2
interaction type: STATE_TRANSITION
right: FRS-2

PDGF s34 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDGF
stoichiometric coefficient: 1.0

uniprot F7HKJ2 500
type: UnificationXref
id: F7HKJ2
db: uniprot

Adapter molecule crk
type: ProteinReference
xref: uniprot Q04929 406
organism: Gallus gallus

Angiogenesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Sck-RIGHT__Sck-_r287
pathway component: STATE_TRANSITION_LEFT__TCF-RIGHT__TCF-_r189
pathway component: STATE_TRANSITION_LEFT__Dsh-RIGHT__Dsh-_r188
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r204
pathway component: STATE_TRANSITION_LEFT__SHC-RIGHT__SHC-_r222
pathway component: STATE_TRANSITION_LEFT__Src-RIGHT__Src-_r288
pathway component: STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r234
pathway component: STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r290
pathway component: STATE_TRANSITION_LEFT__JNKK1-RIGHT__JNKK1-_r245
pathway component: STATE_TRANSITION_LEFT__PLD-RIGHT__PLD-_r206
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r297
pathway component: STATE_TRANSITION_LEFT__PLC_gamma-RIGHT__PLC_gamma-_r285
pathway component: HETERODIMER_ASSOCIATION_LEFT__FGFR_1-_FGF-RIGHT__Complex__FGFR_1_FGF_-_r202
pathway component: STATE_TRANSITION_LEFT__STAT1-RIGHT__STAT1-_r253
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r175
pathway component: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r231
pathway component: STATE_TRANSITION_LEFT__Survivin-RIGHT__Survivin-_r255
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r279
pathway component: STATE_TRANSITION_LEFT__c_Jun-RIGHT__c_Jun-_r248
pathway component: STATE_TRANSITION_LEFT__STAT3-RIGHT__STAT3-_r177
pathway component: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re109
pathway component: STATE_TRANSITION_LEFT__Ang_1-RIGHT__Ang_1-_re113
pathway component: STATE_TRANSITION_LEFT__c_Jun-RIGHT__c_Jun-_r154
pathway component: STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_r291
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS_-_eNOS-RIGHT__Complex__eNOS_Ca2_PLUS_-_r295
pathway component: STATE_TRANSITION_LEFT__PLA2-RIGHT__PLA2-_r207
pathway component: STATE_TRANSITION_LEFT__GTPase-RIGHT__GTPase-_r156
pathway component: STATE_TRANSITION_LEFT__Crk-RIGHT__Crk-_r221
pathway component: STATE_TRANSITION_LEFT__FRS_2-RIGHT__FRS_2-_r223
pathway component: STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r275
pathway component: STATE_TRANSITION_LEFT__GAP-RIGHT__GAP-_r247
pathway component: STATE_TRANSITION_LEFT__STAT1-RIGHT__STAT1-_r178
pathway component: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r281
pathway component: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r280
pathway component: STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_r292
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r284
pathway component: STATE_TRANSITION_LEFT__JNK1-RIGHT__JNK1-_r246
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r282
pathway component: HETERODIMER_ASSOCIATION_LEFT__c_Fos-_c_Jun-RIGHT__Complex__c_Jun_c_Fos_-_r155
pathway component: STATE_TRANSITION_LEFT__MEKK1-RIGHT__MEKK1-_r244
pathway component: STATE_TRANSITION_LEFT__JNKK1-RIGHT__JNKK1-_r152
pathway component: STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r261
pathway component: HETERODIMER_ASSOCIATION_LEFT__EphR-_Eph-RIGHT__Complex__EphR_Eph_-_r174
pathway component: STATE_TRANSITION_LEFT__p38MAPK-RIGHT__p38MAPK-_r294
pathway component: STATE_TRANSITION_LEFT__CSL-RIGHT__CSL-_r146
pathway component: STATE_TRANSITION_LEFT__HIF_1-RIGHT__HIF_1-_r276
pathway component: STATE_TRANSITION_LEFT__MAPKAPK2_3-RIGHT__MAPKAPK2_3-_r293
pathway component: STATE_TRANSITION_LEFT__Nck-RIGHT__Nck-_r270
pathway component: HETERODIMER_ASSOCIATION_LEFT__Tie2-_Ang_1-RIGHT__Complex__Tie2_Ang_1_-_r267
pathway component: HETERODIMER_ASSOCIATION_LEFT__Notch-_Delta_Serrate-RIGHT__Complex__Notch_Delta__Serrate_-_r145
pathway component: STATE_TRANSITION_LEFT__JAK1-RIGHT__JAK1-_r252
pathway component: STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re105
pathway component: STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r301
pathway component: STATE_TRANSITION_LEFT__Dok_R-RIGHT__Dok_R-_r271
pathway component: STATE_TRANSITION_LEFT__Shp_2-RIGHT__Shp_2-_r224
pathway component: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r230
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r260
pathway component: STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_re106
pathway component: STATE_TRANSITION_LEFT__RasGAP-RIGHT__RasGAP-_r274
pathway component: HETERODIMER_ASSOCIATION_LEFT__PDGF-_PDGFR-RIGHT__Complex__PDGFR_PDGF_-_r237
pathway component: STATE_TRANSITION_LEFT__MEKK1-RIGHT__MEKK1-_r151
pathway component: STATE_TRANSITION_LEFT__Erk-RIGHT__Erk-_r183
pathway component: STATE_TRANSITION_LEFT__PAR-RIGHT__PAR-_r147
pathway component: STATE_TRANSITION_LEFT__SOS_1-RIGHT__SOS_1-_r226
pathway component: STATE_TRANSITION_LEFT__Shp_2-RIGHT__Shp_2-_r262
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r232
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r300
pathway component: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r157
pathway component: STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_re108
pathway component: HETERODIMER_ASSOCIATION_LEFT__GSK3beta-_APC-_Axin-RIGHT__Complex__Axin_APC__GSK3beta_-_r190
pathway component: STATE_TRANSITION_LEFT__Complex__Tie2_Ang_1_-RIGHT__Complex__Tie2_Ang_1_-_re115
pathway component: STATE_TRANSITION_LEFT__GRB2-RIGHT__GRB2-_r225
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS_-_cPLA2-RIGHT__Complex__cPLA2_endsub_Ca2_PLUS__endsuper_-_r277
pathway component: STATE_TRANSITION_LEFT__Grb2-RIGHT__Grb2-_r272
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r250
pathway component: STATE_TRANSITION_LEFT__SPK-RIGHT__SPK-_r283
pathway component: STATE_TRANSITION_LEFT__STAT3-RIGHT__STAT3-_r254
pathway component: HETERODIMER_ASSOCIATION_LEFT__c_Fos-_c_Jun-RIGHT__Complex__c_Jun_c_Fos_-_r249
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r182

PARTICIPANT STOICHIOMETRY r282 1372
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r282 1373
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot Q9UP38 141
type: UnificationXref
id: Q9UP38
db: uniprot

Baculoviral IAP repeat-containing protein 5
type: ProteinReference
xref: uniprot Q6J1J1 236
xref: PTHR10044:SF166
organism: Bos taurus

uniprot Q9GZT5 389
type: UnificationXref
id: Q9GZT5
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Fzd-_Wnt-RIGHT__Complex__Wnt_Fzd_-_r186
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r186 1382
participant stoichiometry: PARTICIPANT STOICHIOMETRY r186 1380
participant stoichiometry: PARTICIPANT STOICHIOMETRY r186 1381
left: Fzd
left: Wnt
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Wnt/Fzd)

Delta-like protein C
type: ProteinReference
xref: uniprot Q9IAT6 757
organism: Danio rerio

Sizzled
type: ProteinReference
xref: uniprot F6ZIJ4 973
xref: PTHR11309:SF11
organism: Xenopus tropicalis

uniprot F7H3B3 579
type: UnificationXref
id: F7H3B3
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 12

uniprot E2R9F8 1190
type: UnificationXref
id: E2R9F8
db: uniprot

MAPKAPK2 isoform 1
type: ProteinReference
xref: uniprot H2Q104 1097
xref: PTHR24349:SF63
organism: Pan troglodytes

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: uniprot Q8CIN4 1177
xref: PTHR48015:SF22
organism: Mus musculus

uniprot Q2QLE7 379
type: UnificationXref
id: Q2QLE7
db: uniprot

uniprot O70240 1198
type: UnificationXref
id: O70240
db: uniprot

uniprot Q16644 1102
type: UnificationXref
id: Q16644
db: uniprot

uniprot F6Z0J4 912
type: UnificationXref
id: F6Z0J4
db: uniprot

uniprot Q64303 1175
type: UnificationXref
id: Q64303
db: uniprot

AGAP002123-PA
type: ProteinReference
xref: uniprot Q7PYV4 1202
organism: Anopheles gambiae

Platelet-derived growth factor subunit A
type: ProteinReference
xref: uniprot P20033 693
organism: Mus musculus

uniprot P49137 1100
type: UnificationXref
id: P49137
db: uniprot

PARTICIPANT STOICHIOMETRY re107 1471
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

Grb7
type: Protein
entity reference: Grb7
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NXB2 246
xref: PTHR10878:SF6
organism: Gallus gallus

uniprot P01100 874
type: UnificationXref
id: P01100
db: uniprot

PARTICIPANT STOICHIOMETRY re107 1472
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

SHC
type: Protein
entity reference: SHC
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P26618 794
type: UnificationXref
id: P26618
db: uniprot

uniprot P63086 295
type: UnificationXref
id: P63086
db: uniprot

Fzd
type: ProteinReference
xref: P00189
standard name: Frizzled
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.RECEPTOR.Fzd
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
comment: ENTITY_REFERENCE_NOTES=Long Name: Frizzled Synonym: Synonym not specified Accession: P00189
member entity reference: Frizzled-3
member entity reference: Frizzled class receptor 5
member entity reference: Frizzled class receptor 2
member entity reference: Frizzled-1
member entity reference: Frizzled
member entity reference: Frizzled-2
member entity reference: FZD3 isoform 1
member entity reference: FZD5 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Frizzled class receptor 8b
member entity reference: Frizzled class receptor 1
member entity reference: Frizzled-5
member entity reference: Frizzled class receptor 3
member entity reference: FZD1 protein

Frizzled-related protein
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot Q9W6E0 985
organism: Danio rerio

KDR isoform 1
type: ProteinReference
xref: uniprot H2QPH6 636
xref: PTHR24416:SF45
organism: Pan troglodytes

TCF
type: ProteinReference
xref: P00242
standard name: T-Cell Transcription Factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: T-Cell Transcription Factor Synonym: TCF4,Transcription Factor 7-Like 2 Accession: P00242
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.TCF
member entity reference: Transcription factor 7
member entity reference: Transcription factor 7-like 2

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot P61585 1225
organism: Bos taurus

Transforming protein RhoA
type: ProteinReference
xref: uniprot P61586 1226
xref: PTHR24072:SF153
organism: Homo sapiens

PTHR12607:SF11
type: RelationshipXref
id: PTHR12607:SF11
db: PANTHER Family
relationship type: By Homology

PTHR24278:SF26
type: RelationshipXref
id: PTHR24278:SF26
db: PANTHER Family
relationship type: By Homology

uniprot F6RWK1 1111
type: UnificationXref
id: F6RWK1
db: uniprot

uniprot D4AEG0 842
type: UnificationXref
id: D4AEG0
db: uniprot

Axin 1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot H2R1H5 1193
organism: Pan troglodytes

uniprot D3ZCD0 1144
type: UnificationXref
id: D3ZCD0
db: uniprot

uniprot E9I1I7 992
type: UnificationXref
id: E9I1I7
db: uniprot

Axin-1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot A0A1D5P395 1189
organism: Gallus gallus

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot D4A3M8 505
organism: Rattus norvegicus

uniprot P28047 368
type: UnificationXref
id: P28047
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF87
xref: uniprot F6XUZ7 343
organism: Monodelphis domestica

uniprot A4IFJ5 765
type: UnificationXref
id: A4IFJ5
db: uniprot

uniprot A0A0G2K344 878
type: UnificationXref
id: A0A0G2K344
db: uniprot

PARTICIPANT STOICHIOMETRY r188 1375
type: Stoichiometry
physical entity: Dsh
stoichiometric coefficient: 1.0

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot F6RA79 570
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r188 1374
type: Stoichiometry
physical entity: Dsh
stoichiometric coefficient: 1.0

uniprot P70313 437
type: UnificationXref
id: P70313
db: uniprot

uniprot F6UQ33 768
type: UnificationXref
id: F6UQ33
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q04970 1019
xref: PTHR24070:SF189
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot F7HRY3 257
organism: Macaca mulatta

Ras homolog family member C
type: ProteinReference
xref: uniprot A0A2I3S4I6 1204
xref: PTHR24072:SF100
organism: Pan troglodytes

Protein CBR-KIN-32
type: ProteinReference
xref: uniprot A8XBU1 423
organism: Caenorhabditis briggsae

GSK3beta
type: Protein
entity reference: GSK3beta
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa11 1339
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7DNM3 144
type: UnificationXref
id: F7DNM3
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q07890 178
organism: Homo sapiens

uniprot F1PIB1 254
type: UnificationXref
id: F1PIB1
db: uniprot

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: uniprot Q9WVB9 273
xref: PTHR10878:SF5
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F6W3Y0 1159
organism: Xenopus tropicalis

uniprot P05128 591
type: UnificationXref
id: P05128
db: uniprot

uniprot A0A2J8MK73 838
type: UnificationXref
id: A0A2J8MK73
db: uniprot

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot Q2QLE7 379
organism: Pan troglodytes

Frizzled class receptor 3
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot E2R9M9 114
organism: Canis lupus familiaris

uniprot F1MX38 526
type: UnificationXref
id: F1MX38
db: uniprot

uniprot E2QUR0 722
type: UnificationXref
id: E2QUR0
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 6

uniprot F6QP11 660
type: UnificationXref
id: F6QP11
db: uniprot

uniprot Q9NHC3 412
type: UnificationXref
id: Q9NHC3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Grb14-RIGHT__Grb14-_r268
controller: Complex (Tie2/Ang-1)

uniprot P92208 649
type: UnificationXref
id: P92208
db: uniprot

uniprot P04085 692
type: UnificationXref
id: P04085
db: uniprot

c-Jun
type: Protein
entity reference: c-Jun
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P04627 1080
organism: Mus musculus

PLA2G4C isoform 4
type: ProteinReference
xref: uniprot H2QGQ4 1184
organism: Pan troglodytes

Proto-oncogene Wnt-1
type: ProteinReference
xref: uniprot P04628 360
xref: PTHR12027:SF91
organism: Homo sapiens

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot B1NA68 240
organism: Danio rerio

uniprot A7S9Y5 1207
type: UnificationXref
id: A7S9Y5
db: uniprot

PTHR46957:SF2
type: RelationshipXref
id: PTHR46957:SF2
db: PANTHER Family
relationship type: By Homology

EPH receptor B2
type: ProteinReference
xref: PTHR24416:SF123
xref: uniprot F7EAT1 466
organism: Monodelphis domestica

uniprot Q8C4U3 979
type: UnificationXref
id: Q8C4U3
db: uniprot

uniprot F7FR08 1215
type: UnificationXref
id: F7FR08
db: uniprot

uniprot B1NA68 240
type: UnificationXref
id: B1NA68
db: uniprot

Phospholipase
type: ProteinReference
xref: PTHR18896:SF57
xref: uniprot H2R1L6 304
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r152 1496
type: Stoichiometry
physical entity: JNKK1
stoichiometric coefficient: 1.0

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 1068
xref: uniprot P05625 1081
xref: PTHR44329:SF22
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r152 1497
type: Stoichiometry
physical entity: JNKK1
stoichiometric coefficient: 1.0

uniprot F6YCI3 170
type: UnificationXref
id: F6YCI3
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05627 543
organism: Mus musculus

uniprot A4FV00 644
type: UnificationXref
id: A4FV00
db: uniprot

Protein C-ets-1
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot P27577 106
organism: Mus musculus

FRS-2
type: Protein
entity reference: FRS-2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q9DGD9 651
xref: PTHR24055:SF222
organism: Danio rerio

Platelet-derived growth factor receptor beta
type: ProteinReference
xref: uniprot P05622 790
organism: Mus musculus

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF448
xref: uniprot E1BDN7 720
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLD-RIGHT__PLD-_r206
controller: PKC

Dishevelled segment polarity protein 2
type: ProteinReference
xref: uniprot D3ZB71 249
xref: PTHR10878:SF8
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DNM3 144
xref: PTHR10194:SF19
organism: Macaca mulatta

uniprot E2RTE0 192
type: UnificationXref
id: E2RTE0
db: uniprot

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE1 37
organism: Danio rerio

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q9DGE2 39
organism: Danio rerio

uniprot Q22070 1284
type: UnificationXref
id: Q22070
db: uniprot

uniprot Q7Q724 833
type: UnificationXref
id: Q7Q724
db: uniprot

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

Ras
type: Protein
entity reference: Ras
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O35904 934
organism: Mus musculus

uniprot F6WBD5 88
type: UnificationXref
id: F6WBD5
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot F7HC75 580
organism: Macaca mulatta

Delta-like protein 1
type: ProteinReference
xref: uniprot O00548 738
organism: Homo sapiens

EphR s227 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EphR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PLD-RIGHT__PLD-_r206
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r206 1430
participant stoichiometry: PARTICIPANT STOICHIOMETRY r206 1429
left: PLD
interaction type: STATE_TRANSITION
right: PLD

Complex (Tie2/Ang-1)
type: Complex
component stoichiometry: Tie2 s225 sa235 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ang 1 s226 sa236 STOICHIOMETRY ID COMPLEX
component: Ang-1
component: Tie2
feature: COMPLEX BINDING FEATURE s196 csa14 1296
feature: COMPLEX BINDING FEATURE s196 csa14 1298
cellular location: plasma membrane

uniprot P50393 778
type: UnificationXref
id: P50393
db: uniprot

Frizzled-related protein
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot B2GUW1 969
organism: Rattus norvegicus

uniprot F1N0D6 75
type: UnificationXref
id: F1N0D6
db: uniprot

PARTICIPANT STOICHIOMETRY r182 1385
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot D4A3T0 163
organism: Rattus norvegicus

PTHR10336:SF25
type: RelationshipXref
id: PTHR10336:SF25
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r182 1386
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot H2QIH7 512
type: UnificationXref
id: H2QIH7
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__VEGF-_VEGFR_2-RIGHT__Complex__VEGFR_2_VEGF_-_r289
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r289 1345
participant stoichiometry: PARTICIPANT STOICHIOMETRY r289 1346
participant stoichiometry: PARTICIPANT STOICHIOMETRY r289 1344
left: VEGFR-2
left: VEGF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (VEGFR-2/VEGF)

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Src-RIGHT__Src-_r220
controller: Complex (FGFR-1/FGF)

uniprot Q02750 710
type: UnificationXref
id: Q02750
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot E2RIF9 897
organism: Canis lupus familiaris

uniprot P36402 1063
type: UnificationXref
id: P36402
db: uniprot

AGAP002219-PA
type: ProteinReference
xref: uniprot Q7QK91 1024
organism: Anopheles gambiae

uniprot Q9QZC5 784
type: UnificationXref
id: Q9QZC5
db: uniprot

VRAP
type: Protein
entity reference: VRAP
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7ENN2 732
type: UnificationXref
id: F7ENN2
db: uniprot

uniprot K7BZ54 815
type: UnificationXref
id: K7BZ54
db: uniprot

PARTICIPANT STOICHIOMETRY r269 1436
type: Stoichiometry
physical entity: Pak
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r269 1437
type: Stoichiometry
physical entity: Pak
stoichiometric coefficient: 1.0

Pak
type: ProteinReference
xref: P00249
standard name: p21-activated kinase
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Pak
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: p21-Activated Kinase Synonym: PAK Accession: P00249
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: Serine/threonine-protein kinase PAK 2
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase PAK 1
member entity reference: Serine/threonine-protein kinase PAK 3
member entity reference: Serine/threonine-protein kinase pak-1

uniprot P26824 159
type: UnificationXref
id: P26824
db: uniprot

PARTICIPANT STOICHIOMETRY re109 1463
type: Stoichiometry
physical entity: beta catenin
stoichiometric coefficient: 1.0

uniprot F7CBU9 769
type: UnificationXref
id: F7CBU9
db: uniprot

PARTICIPANT STOICHIOMETRY re109 1462
type: Stoichiometry
physical entity: beta catenin
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HIF_1-RIGHT__HIF_1-_r276
controller: Erk

uniprot E2REI6 1075
type: UnificationXref
id: E2REI6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A2I3SHP7 1272
organism: Pan troglodytes

Protein Wnt
type: ProteinReference
xref: uniprot A0A1D5NX70 317
xref: PTHR12027:SF93
organism: Gallus gallus

YALI0E23001p
type: ProteinReference
xref: uniprot Q6C4X3 1239
organism: Yarrowia lipolytica

uniprot A7MB15 110
type: UnificationXref
id: A7MB15
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r280
control type: INHIBITION
controller: Dok-R

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 191

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 265

uniprot Q03160 782
type: UnificationXref
id: Q03160
db: uniprot

uniprot F6QAW3 118
type: UnificationXref
id: F6QAW3
db: uniprot

Nitric oxide synthase
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot F6S3S1 434
organism: Monodelphis domestica

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q07889 177
organism: Homo sapiens

uniprot F7EI48 287
type: UnificationXref
id: F7EI48
db: uniprot

uniprot P02510 820
type: UnificationXref
id: P02510
db: uniprot

uniprot P40763 530
type: UnificationXref
id: P40763
db: uniprot

uniprot Q6QNF3 796
type: UnificationXref
id: Q6QNF3
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O08908 933
organism: Mus musculus

uniprot E2RSH8 49
type: UnificationXref
id: E2RSH8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 283
organism: Canis lupus familiaris

uniprot H2Q989 1183
type: UnificationXref
id: H2Q989
db: uniprot

CRYAA isoform 1
type: ProteinReference
xref: uniprot A0A2I3RKP9 806
organism: Pan troglodytes

GTP-binding protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot O93467 1219
organism: Gallus gallus

HETERODIMER_ASSOCIATION_LEFT__EphR-_Eph-RIGHT__Complex__EphR_Eph_-_r174
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r174 1421
participant stoichiometry: PARTICIPANT STOICHIOMETRY r174 1420
participant stoichiometry: PARTICIPANT STOICHIOMETRY r174 1422
left: EphR
left: Eph
interaction type: HETERODIMER_ASSOCIATION
right: Complex (EphR/Eph)

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Shp_2-RIGHT__Shp_2-_r262
controller: Complex (Tie2/Ang-1)

uniprot P18824 91
type: UnificationXref
id: P18824
db: uniprot

uniprot F6XMN6 571
type: UnificationXref
id: F6XMN6
db: uniprot

GTP-binding protein
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot O93468 1220
organism: Gallus gallus

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot E2R9U3 723
organism: Canis lupus familiaris

PTHR24033:SF188
type: RelationshipXref
id: PTHR24033:SF188
db: PANTHER Family
relationship type: By Homology

Ras homolog family member A
type: ProteinReference
xref: uniprot Q28GJ8 1234
xref: PTHR24072:SF153
organism: Xenopus tropicalis

Cytoplasmic protein
type: ProteinReference
xref: uniprot F7GD33 510
xref: PTHR19969:SF16
organism: Monodelphis domestica

uniprot Q3SZ41 853
type: UnificationXref
id: Q3SZ41
db: uniprot

uniprot F6WG78 486
type: UnificationXref
id: F6WG78
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q63789 955
organism: Rattus norvegicus

uniprot A0A1D5QZZ0 221
type: UnificationXref
id: A0A1D5QZZ0
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot Q63788 954
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot A0A3Q1M0G8 1152
organism: Bos taurus

V-crk avian sarcoma virus CT10 oncogene homolog-like
type: ProteinReference
xref: uniprot Q6PH06 410
organism: Danio rerio

uniprot D4A3T0 163
type: UnificationXref
id: D4A3T0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r282
controller: DAG

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot F7FGD2 577
organism: Monodelphis domestica

uniprot Q9W6E0 985
type: UnificationXref
id: Q9W6E0
db: uniprot

PARTICIPANT STOICHIOMETRY r174 1422
type: Stoichiometry
physical entity: Complex (EphR/Eph)
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot E1BE66 894
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r174 1421
type: Stoichiometry
physical entity: Eph
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r174 1420
type: Stoichiometry
physical entity: EphR
stoichiometric coefficient: 1.0

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot E2RB53 443
organism: Canis lupus familiaris

uniprot B0S6S2 111
type: UnificationXref
id: B0S6S2
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: uniprot Q90XF2 629
xref: PTHR24356:SF214
organism: Danio rerio

AGAP010687-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PRL1 313
organism: Anopheles gambiae

PTHR11801:SF18
type: RelationshipXref
id: PTHR11801:SF18
db: PANTHER Family
relationship type: By Homology

uniprot D3ZRW5 330
type: UnificationXref
id: D3ZRW5
db: uniprot

PTHR24033:SF176
type: RelationshipXref
id: PTHR24033:SF176
db: PANTHER Family
relationship type: By Homology

uniprot Q7PZG1 1106
type: UnificationXref
id: Q7PZG1
db: uniprot

Delta-like protein
type: ProteinReference
xref: uniprot F7BUF3 729
organism: Macaca mulatta

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q60823 672
organism: Mus musculus

Complex (Tie2/Ang-1)
type: Complex
component stoichiometry: Ang 1 s226 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tie2 s225 sa20 STOICHIOMETRY ID COMPLEX
component: Ang-1
component: Tie2
feature: COMPLEX BINDING FEATURE s196 a268 1300
feature: COMPLEX BINDING FEATURE s196 a268 1302
cellular location: plasma membrane

Lin-12 And Glp-1 phenotype
type: ProteinReference
xref: uniprot V6CLJ5 855
organism: Caenorhabditis elegans

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

uniprot F6WX28 871
type: UnificationXref
id: F6WX28
db: uniprot

NOTCH1 isoform 1
type: ProteinReference
xref: PTHR45836:SF12
xref: uniprot H2QY65 1259
organism: Pan troglodytes

SFRP1 isoform 1
type: ProteinReference
xref: uniprot H2R9U6 977
xref: PTHR11309:SF87
organism: Pan troglodytes

Proline-rich protein 5
type: ProteinReference
xref: uniprot Q812A5 1124
organism: Mus musculus

ncbitaxon 10090 17
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot Q63722 751
type: UnificationXref
id: Q63722
db: uniprot

uniprot P80370 746
type: UnificationXref
id: P80370
db: uniprot

uniprot P22726 365
type: UnificationXref
id: P22726
db: uniprot

PTHR24349:SF63
type: RelationshipXref
id: PTHR24349:SF63
db: PANTHER Family
relationship type: By Homology

PANTHER Pathway P00005 1
type: UnificationXref
id: P00005
db: PANTHER Pathway

PTHR24349:SF64
type: RelationshipXref
id: PTHR24349:SF64
db: PANTHER Family
relationship type: By Homology

Segment polarity protein dishevelled homolog DVL-2
type: ProteinReference
xref: uniprot Q60838 268
xref: PTHR10878:SF8
organism: Mus musculus

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P45985 244
xref: PTHR48013:SF20
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6T0E0 1112
xref: PTHR45808:SF6
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Dok_R-RIGHT__Dok_R-_r271
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r271 1413
participant stoichiometry: PARTICIPANT STOICHIOMETRY r271 1412
left: Dok-R
interaction type: STATE_TRANSITION
right: Dok-R

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 648
xref: PTHR24055:SF222
organism: Homo sapiens

Glycogen synthase kinase-3 beta isoform 1
type: ProteinReference
xref: uniprot H9EPM1 446
xref: PTHR24057:SF8
organism: Macaca mulatta

Adapter molecule crk
type: ProteinReference
xref: PTHR19969:SF8
xref: uniprot Q63768 408
organism: Rattus norvegicus

uniprot Q17941 671
type: UnificationXref
id: Q17941
db: uniprot

CRYAB isoform 1
type: ProteinReference
xref: uniprot A0A2J8L0C8 807
organism: Pan troglodytes

uniprot F7DXH6 51
type: UnificationXref
id: F7DXH6
db: uniprot

Grb2
type: ProteinReference
xref: P00252
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Grb2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Growth Factor Receptor-Bound Protein 2 Synonym: ASH Protein,Abundant SRC Homology,Adaptor Protein 2 Accession: P00234
member entity reference: Growth factor receptor-bound protein 2a
member entity reference: GRB2-related adapter protein
member entity reference: Sex muscle abnormal protein 5
member entity reference: GRB2-related adaptor protein
member entity reference: Growth factor receptor-bound protein 2
member entity reference: Protein enhancer of sevenless 2B
member entity reference: Protein CBR-SEM-5

STATE_TRANSITION_LEFT__GAP-RIGHT__GAP-_r247
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r247 1506
participant stoichiometry: PARTICIPANT STOICHIOMETRY r247 1505
left: GAP
interaction type: STATE_TRANSITION
right: GAP

Fibroblast growth factor
type: ProteinReference
xref: uniprot F6SXE2 485
xref: PTHR11486:SF83
organism: Macaca mulatta

Protein Wnt
type: ProteinReference
xref: uniprot F6XMD3 342
xref: PTHR12027:SF93
organism: Xenopus tropicalis

Ang-1
type: ProteinReference
xref: P00248
standard name: Angiopoietin-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Angiopoietin-1 Synonym: Synonym not specified Accession: P00248
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Ang-1
member entity reference: Angiopoietin-1
member entity reference: Angiopoietin 1
member entity reference: ANGPT1 isoform 2
member entity reference: Uncharacterized protein

Protein kinase C iota type
type: ProteinReference
xref: uniprot F1M7Y5 564
xref: PTHR24356:SF214
organism: Rattus norvegicus

GRB2-related adaptor protein
type: ProteinReference
xref: uniprot Q4KM68 862
organism: Rattus norvegicus

Ephrin-B1
type: ProteinReference
xref: uniprot A1L570 1027
organism: Bos taurus

uniprot P52800 1040
type: UnificationXref
id: P52800
db: uniprot

PARTICIPANT STOICHIOMETRY r261 1455
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

uniprot E2R6T4 539
type: UnificationXref
id: E2R6T4
db: uniprot

PARTICIPANT STOICHIOMETRY r261 1454
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

GTPase HRas
type: ProteinReference
xref: uniprot Q61411 1023
xref: PTHR24070:SF385
organism: Mus musculus

Platelet-derived growth factor subunit B
type: ProteinReference
xref: uniprot P31240 695
organism: Mus musculus

uniprot A0A2I3T3L8 420
type: UnificationXref
id: A0A2I3T3L8
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6QE96 659
organism: Macaca mulatta

Delta-like protein
type: ProteinReference
xref: uniprot E1BTW5 721
xref: PTHR24044:SF448
organism: Gallus gallus

Phosphoinositide-3-kinase regulatory subunit 2
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot H2QFS6 926
organism: Pan troglodytes

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot Q2QL96 378
organism: Monodelphis domestica

P00189
type: UnificationXref
id: P00189
db: PANTHER Pathway Component

PTHR19969:SF8
type: RelationshipXref
id: PTHR19969:SF8
db: PANTHER Family
relationship type: By Homology

P00188
type: UnificationXref
id: P00188
db: PANTHER Pathway Component

P00187
type: UnificationXref
id: P00187
db: PANTHER Pathway Component

P00186
type: UnificationXref
id: P00186
db: PANTHER Pathway Component

P00185
type: UnificationXref
id: P00185
db: PANTHER Pathway Component

P00184
type: UnificationXref
id: P00184
db: PANTHER Pathway Component

P00183
type: UnificationXref
id: P00183
db: PANTHER Pathway Component

P00182
type: UnificationXref
id: P00182
db: PANTHER Pathway Component

PDGFR
type: Protein
entity reference: PDGFR
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

P00180
type: UnificationXref
id: P00180
db: PANTHER Pathway Component

PTHR10048:SF7
type: RelationshipXref
id: PTHR10048:SF7
db: PANTHER Family
relationship type: By Homology

PTHR11801:SF2
type: RelationshipXref
id: PTHR11801:SF2
db: PANTHER Family
relationship type: By Homology

uniprot P24723 603
type: UnificationXref
id: P24723
db: uniprot

PTHR12358:SF47
type: RelationshipXref
id: PTHR12358:SF47
db: PANTHER Family
relationship type: By Homology

Grb14
type: Protein
entity reference: Grb14
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6TYA8 255
type: UnificationXref
id: F6TYA8
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RJA0 1156
xref: PTHR48015:SF22
organism: Canis lupus familiaris

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot E2RB82 525
organism: Canis lupus familiaris

FGF s31 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FGF
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PAR-RIGHT__PAR-_r147
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r147 1514
participant stoichiometry: PARTICIPANT STOICHIOMETRY r147 1513
left: PAR
interaction type: STATE_TRANSITION
right: PAR

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: uniprot Q9WV60 453
xref: PTHR24057:SF8
organism: Mus musculus

uniprot F7HEB2 781
type: UnificationXref
id: F7HEB2
db: uniprot

PARTICIPANT STOICHIOMETRY r221 1359
type: Stoichiometry
physical entity: Crk
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NE37 684
organism: Gallus gallus

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P10398 1082
organism: Homo sapiens

Ras
type: ProteinReference
xref: P00238
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras Synonym: H-Ras,K-Ras,N-Ras,p21 Accession: P00238
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Ras
member entity reference: Uncharacterized protein rasC
member entity reference: Predicted protein
member entity reference: Ras-like protein rasG
member entity reference: Uncharacterized protein rasS
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: Ras-like protein rasC
member entity reference: Uncharacterized protein
member entity reference: Uncharacterized protein rasD
member entity reference: Uncharacterized protein rasG
member entity reference: Ras-like protein rasB
member entity reference: GTPase NRas
member entity reference: Ras-like protein 1
member entity reference: GTPase HRas
member entity reference: Ras-like protein rasS
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: Uncharacterized protein rasB
member entity reference: GTPase HRas isoform 1
member entity reference: GTPase KRas
member entity reference: AGAP002219-PA
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: Ras-like protein rasD
member entity reference: HRAS isoform 2
member entity reference: Ras protein let-60
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: NRAS protein
member entity reference: NRAS isoform 1
member entity reference: Protein CBR-LET-60

Protein Wnt-2b
type: ProteinReference
xref: uniprot Q93097 386
xref: PTHR12027:SF93
organism: Homo sapiens

Recombining binding protein suppressor of hairless
type: ProteinReference
xref: uniprot P31266 851
xref: PTHR10665:SF3
organism: Mus musculus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A2I3SIH9 47
xref: PTHR24418:SF53
organism: Pan troglodytes

alpha-crystallin A chain-like
type: ProteinReference
xref: uniprot F6RRK4 812
organism: Ciona intestinalis

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot O88763 938
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Grb7-RIGHT__Grb7-_r263
controller: Complex (Tie2/Ang-1)

uniprot O00459 931
type: UnificationXref
id: O00459
db: uniprot

PARTICIPANT STOICHIOMETRY r221 1360
type: Stoichiometry
physical entity: Crk
stoichiometric coefficient: 1.0

uniprot B1H0W5 683
type: UnificationXref
id: B1H0W5
db: uniprot

FVIIa
type: Protein
entity reference: FVIIa
comment: SPECIES_TYPE=PROTEIN

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot P18266 447
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r283 1369
type: Stoichiometry
physical entity: SPK
stoichiometric coefficient: 1.0

IP3
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r283 1368
type: Stoichiometry
physical entity: SPK
stoichiometric coefficient: 1.0

Secreted frizzled-related protein 3
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot Q92765 981
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r202 1442
type: Stoichiometry
physical entity: FGFR-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r202 1443
type: Stoichiometry
physical entity: FGF
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot Q6DV79 533
organism: Gallus gallus

Dishevelled segment polarity protein 1
type: ProteinReference
xref: uniprot E2QY91 251
xref: PTHR10878:SF5
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r202 1444
type: Stoichiometry
physical entity: Complex (FGFR-1/FGF)
stoichiometric coefficient: 1.0

Phospholipase A2
type: ProteinReference
xref: uniprot F6QDY0 767
xref: PTHR10728:SF13
organism: Ornithorhynchus anatinus

Protein Wnt-10b
type: ProteinReference
xref: uniprot P48614 374
xref: PTHR12027:SF76
organism: Mus musculus

PLD
type: Protein
entity reference: PLD
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r151 1499
type: Stoichiometry
physical entity: MEKK1
stoichiometric coefficient: 1.0

Paxillin
type: Protein
entity reference: Paxillin
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r151 1498
type: Stoichiometry
physical entity: MEKK1
stoichiometric coefficient: 1.0

uniprot O70173 937
type: UnificationXref
id: O70173
db: uniprot

CASP9 isoform 4
type: ProteinReference
xref: uniprot A0A2I3TJU8 520
xref: PTHR10454:SF157
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q3ACS4 888
xref: PTHR10155:SF3
organism: Gallus gallus

uniprot A0A2I3T9Y4 653
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

uniprot A0A2R8RR02 421
type: UnificationXref
id: A0A2R8RR02
db: uniprot

Ras guanine nucleotide exchange factor B
type: ProteinReference
xref: uniprot Q8IS21 183
organism: Dictyostelium discoideum

Cdc42 GTPase-activating protein
type: ProteinReference
xref: uniprot A4GT58 1108
xref: PTHR45808:SF6
organism: Canis lupus familiaris

uniprot P0C869 1185
type: UnificationXref
id: P0C869
db: uniprot

Evidence 766
type: Evidence
evidence code: ISS
comment: SPACC P50393

Rho GTPase-activating protein 68F
type: ProteinReference
xref: uniprot Q9VTU3 1126
organism: Drosophila melanogaster

uniprot P01101 875
type: UnificationXref
id: P01101
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63085 294
xref: PTHR24055:SF203
organism: Mus musculus

PDGFR
type: Protein
entity reference: PDGFR
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa14 1289
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63086 295
xref: PTHR24055:SF203
organism: Rattus norvegicus

uniprot A0A2I3RKP9 806
type: UnificationXref
id: A0A2I3RKP9
db: uniprot

Segment polarity protein dishevelled homolog mig-5
type: ProteinReference
xref: uniprot Q22227 266
organism: Caenorhabditis elegans

uniprot O88566 1199
type: UnificationXref
id: O88566
db: uniprot

STATE_TRANSITION_LEFT__JAK1-RIGHT__JAK1-_r252
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r252 1482
participant stoichiometry: PARTICIPANT STOICHIOMETRY r252 1481
left: JAK1
interaction type: STATE_TRANSITION
right: JAK1

PTHR24416:SF131
type: RelationshipXref
id: PTHR24416:SF131
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r300 1428
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r300 1427
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_re108
control type: ACTIVATION
controller: Akt

IP3
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7F3S0 917
type: UnificationXref
id: F7F3S0
db: uniprot

uniprot F1NW21 634
type: UnificationXref
id: F1NW21
db: uniprot

Evidence 774
type: Evidence
evidence code: IDA
comment: SPACC P50393

c Jun s16 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

Catenin (Cadherin-associated protein), beta 1, 88kDa
type: ProteinReference
xref: uniprot Q28GC2 95
xref: PTHR45976:SF4
organism: Xenopus tropicalis

uniprot F7ES59 1214
type: UnificationXref
id: F7ES59
db: uniprot

uniprot A0A1D5P395 1189
type: UnificationXref
id: A0A1D5P395
db: uniprot

uniprot F6YLX1 78
type: UnificationXref
id: F6YLX1
db: uniprot

uniprot F7BIC2 574
type: UnificationXref
id: F7BIC2
db: uniprot

SPK
type: Protein
entity reference: SPK
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein kinase C
type: ProteinReference
xref: uniprot F6XMN6 571
xref: PTHR24356:SF170
organism: Canis lupus familiaris

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q02750 710
organism: Homo sapiens

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q62245 182
organism: Mus musculus

uniprot O14640 260
type: UnificationXref
id: O14640
db: uniprot

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot A0A2R8Q8S1 986
organism: Danio rerio

GH01042p
type: ProteinReference
xref: uniprot Q8T0V8 205
organism: Drosophila melanogaster

uniprot E1BQN6 557
type: UnificationXref
id: E1BQN6
db: uniprot

uniprot O15169 1195
type: UnificationXref
id: O15169
db: uniprot

uniprot F7ATU3 814
type: UnificationXref
id: F7ATU3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LWJ8 642
xref: PTHR24055:SF222
organism: Bos taurus

uniprot A0A3Q1M353 1073
type: UnificationXref
id: A0A3Q1M353
db: uniprot

uniprot O43559 1055
type: UnificationXref
id: O43559
db: uniprot

uniprot H2PZ66 80
type: UnificationXref
id: H2PZ66
db: uniprot

uniprot F7E6U7 1138
type: UnificationXref
id: F7E6U7
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q05655 616
organism: Homo sapiens

uniprot A0A2I3RH39 882
type: UnificationXref
id: A0A2I3RH39
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r259
controller: PI3K

JAK1
type: Protein
entity reference: JAK1
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y0P1 455
organism: Strongylocentrotus purpuratus

uniprot Q05397 430
type: UnificationXref
id: Q05397
db: uniprot

GTPase HRas isoform 1
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot F7F5K9 1003
organism: Macaca mulatta

Docking protein 3
type: ProteinReference
xref: uniprot B2RYG7 7
organism: Rattus norvegicus

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: uniprot Q17941 671
organism: Caenorhabditis elegans

Ephrin-B1
type: ProteinReference
xref: uniprot P98172 1041
organism: Homo sapiens

PTHR21258:SF40
type: RelationshipXref
id: PTHR21258:SF40
db: PANTHER Family
relationship type: By Homology

uniprot W4Y0P1 455
type: UnificationXref
id: W4Y0P1
db: uniprot

Transforming growth factor beta-1-induced transcript 1 protein
type: ProteinReference
xref: uniprot Q62219 202
organism: Mus musculus

uniprot Q8UUZ6 834
type: UnificationXref
id: Q8UUZ6
db: uniprot

PLC-gamma
type: Protein
entity reference: PLC-gamma
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F1PS03 1276
organism: Canis lupus familiaris

Glycogen synthase kinase
type: ProteinReference
xref: uniprot Q9NL43 451
organism: Ciona intestinalis

Recombination signal-binding protein for immunoglobulin kappa J region-like
type: ProteinReference
xref: PTHR10665:SF2
xref: uniprot D4AEG0 842
organism: Rattus norvegicus

uniprot Q06330 852
type: UnificationXref
id: Q06330
db: uniprot

uniprot P47712 773
type: UnificationXref
id: P47712
db: uniprot

uniprot P28693 473
type: UnificationXref
id: P28693
db: uniprot

dishevelled homolog
type: ProteinReference
xref: uniprot Q9NL46 271
organism: Ciona intestinalis

Angiopoietin-1 receptor
type: ProteinReference
xref: PTHR24416:SF125
xref: uniprot Q02763 1148
organism: Homo sapiens

Transforming growth factor beta-1-induced transcript 1 protein
type: ProteinReference
xref: uniprot O43294 194
organism: Homo sapiens

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot A8KBH6 552
organism: Xenopus tropicalis

V-akt murine thymoma viral oncogene homolog 2,-like
type: ProteinReference
xref: uniprot A0A0R4IY09 652
organism: Danio rerio

uniprot P13677 598
type: UnificationXref
id: P13677
db: uniprot

Uncharacterized protein rasB
type: ProteinReference
xref: uniprot F0ZI47 996
organism: Dictyostelium purpureum

Secreted frizzled-related protein 3
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot Q95117 982
organism: Bos taurus

PTHR22968:SF9
type: RelationshipXref
id: PTHR22968:SF9
db: PANTHER Family
relationship type: By Homology

uniprot Q9TUX8 439
type: UnificationXref
id: Q9TUX8
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F1Q3M8 903
organism: Canis lupus familiaris

Delta-like protein 1
type: ProteinReference
xref: uniprot Q61483 750
xref: PTHR24044:SF380
organism: Mus musculus

uniprot P61585 1225
type: UnificationXref
id: P61585
db: uniprot

Phospholipase A2
type: ProteinReference
xref: uniprot H2Q989 1183
organism: Pan troglodytes

uniprot A0A2I3TSA7 1137
type: UnificationXref
id: A0A2I3TSA7
db: uniprot

Complex (EphR/Eph)
type: Complex
component stoichiometry: EphR s227 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Eph s19 sa6 STOICHIOMETRY ID COMPLEX
component: EphR
component: Eph
feature: COMPLEX BINDING FEATURE s159 a187 1330
feature: COMPLEX BINDING FEATURE s159 a187 1332
cellular location: plasma membrane

uniprot A0A3Q1LJJ3 101
type: UnificationXref
id: A0A3Q1LJJ3
db: uniprot

Protein jagged-1
type: ProteinReference
xref: uniprot Q63722 751
xref: PTHR24044:SF448
organism: Rattus norvegicus

uniprot Q9QXX0 761
type: UnificationXref
id: Q9QXX0
db: uniprot

uniprot F6SLU9 339
type: UnificationXref
id: F6SLU9
db: uniprot

uniprot F0ZB76 994
type: UnificationXref
id: F0ZB76
db: uniprot

ncbitaxon 8364 52
type: UnificationXref
id: 8364
db: ncbitaxon

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H9FVU5 928
xref: PTHR10048:SF107
organism: Macaca mulatta

Protein Wnt-5a
type: ProteinReference
xref: uniprot P41221 372
xref: PTHR12027:SF33
organism: Homo sapiens

PTHR21258:SF14
type: RelationshipXref
id: PTHR21258:SF14
db: PANTHER Family
relationship type: By Homology

IDA
type: EvidenceCodeVocabulary

Complex (Notch/Delta/ Serrate)
type: Complex
component stoichiometry: PAR s222 a8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Delta Serrate s15 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Notch s2 sa1 STOICHIOMETRY ID COMPLEX
component: Notch
component: Delta/Serrate
component: PAR
feature: COMPLEX BINDING FEATURE s148 a158 1314
feature: COMPLEX BINDING FEATURE s148 a158 1316
feature: COMPLEX BINDING FEATURE s148 a158 1312
cellular location: plasma membrane

Protein kinase C
type: ProteinReference
xref: uniprot Q7QCP8 626
organism: Anopheles gambiae

Protein jagged-1b
type: ProteinReference
xref: uniprot Q90Y54 755
organism: Danio rerio

Protein jagged-1a
type: ProteinReference
xref: uniprot Q90Y57 756
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r300
controller: Complex (VEGFR-2/VEGF)

HSP27
type: Protein
entity reference: HSP27
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Inactive tyrosine-protein kinase kin-32
type: ProteinReference
xref: uniprot Q95YD4 431
organism: Caenorhabditis elegans

uniprot P05230 489
type: UnificationXref
id: P05230
db: uniprot

PTHR24416:SF120
type: RelationshipXref
id: PTHR24416:SF120
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F6Y841 911
organism: Canis lupus familiaris

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 1247

PTHR24416:SF123
type: RelationshipXref
id: PTHR24416:SF123
db: PANTHER Family
relationship type: By Homology

uniprot F7FHD1 288
type: UnificationXref
id: F7FHD1
db: uniprot

PTHR24416:SF125
type: RelationshipXref
id: PTHR24416:SF125
db: PANTHER Family
relationship type: By Homology

Protein tyrosine kinase 2
type: ProteinReference
xref: PTHR46221:SF5
xref: uniprot F6WLE6 425
organism: Monodelphis domestica

uniprot A0A2I3TNY5 535
type: UnificationXref
id: A0A2I3TNY5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLA2-RIGHT__PLA2-_r207
controller: PKC

RasGAP
type: Protein
entity reference: RasGAP
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q8C3Q9 522
type: UnificationXref
id: Q8C3Q9
db: uniprot

uniprot E2RH85 896
type: UnificationXref
id: E2RH85
db: uniprot

uniprot Q6AYB2 800
type: UnificationXref
id: Q6AYB2
db: uniprot

Heat shock protein beta-2
type: ProteinReference
xref: uniprot O35878 816
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F6TD14 907
organism: Monodelphis domestica

uniprot Q5IS48 267
type: UnificationXref
id: Q5IS48
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_Jun-RIGHT__c_Jun-_r248
controller: JNK1

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6SW23 905
xref: PTHR10048:SF107
organism: Gallus gallus

uniprot Q965G5 1107
type: UnificationXref
id: Q965G5
db: uniprot

uniprot K7CBH8 587
type: UnificationXref
id: K7CBH8
db: uniprot

uniprot Q2PDT4 198
type: UnificationXref
id: Q2PDT4
db: uniprot

uniprot Q02248 93
type: UnificationXref
id: Q02248
db: uniprot

uniprot Q62219 202
type: UnificationXref
id: Q62219
db: uniprot

uniprot P24622 826
type: UnificationXref
id: P24622
db: uniprot

uniprot E2R2N2 283
type: UnificationXref
id: E2R2N2
db: uniprot

uniprot F6VUQ4 728
type: UnificationXref
id: F6VUQ4
db: uniprot

uniprot Q02156 612
type: UnificationXref
id: Q02156
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 299
organism: Danio rerio

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 1222

uniprot E1C6T4 559
type: UnificationXref
id: E1C6T4
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F6URW3 169
organism: Ornithorhynchus anatinus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_r292
controller: MAPKAPK2/3

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 57

uniprot P50392 777
type: UnificationXref
id: P50392
db: uniprot

STATE_TRANSITION_LEFT__Dsh-RIGHT__Dsh-_r188
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r188 1375
participant stoichiometry: PARTICIPANT STOICHIOMETRY r188 1374
left: Dsh
interaction type: STATE_TRANSITION
right: Dsh

PARTICIPANT STOICHIOMETRY r183 1383
type: Stoichiometry
physical entity: Erk
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r183 1384
type: Stoichiometry
physical entity: Erk
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
type: ProteinReference
xref: uniprot Q22070 1284
organism: Caenorhabditis elegans

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7DXH6 51
xref: PTHR24418:SF53
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UCS9 840
xref: PTHR10665:SF3
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r296
controller: PIP3

uniprot A0A2R8Q1M3 1026
type: UnificationXref
id: A0A2R8Q1M3
db: uniprot

Tissue factor
type: ProteinReference
xref: PTHR20859:SF22
xref: uniprot P42533 154
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: uniprot G3V7U3 348
xref: PTHR12027:SF93
organism: Rattus norvegicus

Ras GTPase-activating protein 1
type: ProteinReference
xref: uniprot P50904 148
xref: PTHR10194:SF19
organism: Rattus norvegicus

uniprot P14921 105
type: UnificationXref
id: P14921
db: uniprot

PARTICIPANT STOICHIOMETRY r189 1370
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r189 1371
type: Stoichiometry
physical entity: TCF
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot F6XGB0 341
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 641
organism: Gallus gallus

uniprot Q8SSQ0 184
type: UnificationXref
id: Q8SSQ0
db: uniprot

Platelet-derived growth factor D
type: ProteinReference
xref: uniprot Q925I7 699
organism: Mus musculus

uniprot E2RTA9 809
type: UnificationXref
id: E2RTA9
db: uniprot

uniprot A0A2I3S3V5 155
type: UnificationXref
id: A0A2I3S3V5
db: uniprot

uniprot F6XMD3 342
type: UnificationXref
id: F6XMD3
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot E2RQM0 1275
xref: PTHR10336:SF25
organism: Canis lupus familiaris

uniprot P98172 1041
type: UnificationXref
id: P98172
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 297
organism: Danio rerio

Protein Wnt-5b
type: ProteinReference
xref: uniprot Q9H1J7 390
xref: PTHR12027:SF87
organism: Homo sapiens

Adenomatous polyposis coli protein
type: ProteinReference
xref: uniprot P70478 216
xref: PTHR12607:SF11
organism: Rattus norvegicus

Platelet-derived growth factor C
type: ProteinReference
xref: uniprot Q9I946 702
organism: Gallus gallus

uniprot F1PHV7 1000
type: UnificationXref
id: F1PHV7
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: uniprot P23298 602
xref: PTHR24356:SF192
organism: Mus musculus

Zgc:101699
type: ProteinReference
xref: uniprot F1QD56 1181
organism: Danio rerio

TF
type: Protein
entity reference: TF
comment: SPECIES_TYPE=PROTEIN

uniprot O88763 938
type: UnificationXref
id: O88763
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 52

ANGPT1 isoform 2
type: ProteinReference
xref: uniprot A0A2I3TSA7 1137
xref: PTHR19143:SF156
organism: Pan troglodytes

STATE_TRANSITION_LEFT__MAPKAPK2_3-RIGHT__MAPKAPK2_3-_r293
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r293 1547
participant stoichiometry: PARTICIPANT STOICHIOMETRY r293 1546
left: MAPKAPK2/3
interaction type: STATE_TRANSITION
right: MAPKAPK2/3

Grb2
type: Protein
entity reference: Grb2
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Fibroblast growth factor 1
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot F7DY09 487
organism: Macaca mulatta

JNK1
type: ProteinReference
xref: P00221
standard name: c-Jun N-Terminal Kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.JNK1
comment: ENTITY_REFERENCE_NOTES=Long Name: c-Jun N-Terminal Kinase 1 Synonym: MAPK8,Mitogen-Activated Protein Kinase 8,PRKM8,Protein Kinase, Mitogen-Activated, 8,SAPK1,Stress-Activated Protein Kinase 1 Accession: P00221
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Stress-activated protein kinase JNK

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r260
controller: Complex (Tie2/Ang-1)

uniprot Q62245 182
type: UnificationXref
id: Q62245
db: uniprot

Alpha-crystallin A chain
type: ProteinReference
xref: uniprot P68280 828
organism: Canis lupus familiaris

uniprot F7B9D9 1032
type: UnificationXref
id: F7B9D9
db: uniprot

MAPKAPK2/3
type: Protein
entity reference: MAPKAPK2/3
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Notch
type: ProteinReference
xref: P00255
standard name: Notch Receptor
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.RECEPTOR.Notch
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Notch 4
member entity reference: Neurogenic locus notch homolog protein 2
member entity reference: Notch 1
member entity reference: Neurogenic locus Notch protein
member entity reference: NOTCH1 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Neurogenic locus notch homolog protein 4
member entity reference: Neurogenic locus notch homolog protein 1

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2R0G7 647
xref: PTHR24055:SF222
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r248 1504
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: uniprot Q62159 1238
xref: PTHR24072:SF100
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r248 1503
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

uniprot P70618 34
type: UnificationXref
id: P70618
db: uniprot

uniprot E2REH3 1155
type: UnificationXref
id: E2REH3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r140
controller: PIP3

uniprot F1MWF1 632
type: UnificationXref
id: F1MWF1
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF12
xref: uniprot E2RR18 563
organism: Canis lupus familiaris

uniprot A0A2I3SRD0 188
type: UnificationXref
id: A0A2I3SRD0
db: uniprot

Phospholipase D2
type: ProteinReference
xref: PTHR18896:SF121
xref: uniprot P70498 309
organism: Rattus norvegicus

uniprot Q9GZP0 701
type: UnificationXref
id: Q9GZP0
db: uniprot

Phospholipase D1
type: ProteinReference
xref: uniprot P70496 308
xref: PTHR18896:SF57
organism: Rattus norvegicus

uniprot Q2QL96 378
type: UnificationXref
id: Q2QL96
db: uniprot

HSP27
type: ProteinReference
xref: P00231
standard name: Heat-Shock Protein 27
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.HSP27
comment: ENTITY_REFERENCE_NOTES=Long Name: Heat-Shock Protein 27 Synonym: HSPB1 Accession: P00231
member entity reference: Uncharacterized protein
member entity reference: Heat shock protein beta-1
member entity reference: Alpha-crystallin B chain
member entity reference: Alpha-crystallin A chain
member entity reference: HSPB2 isoform 1
member entity reference: Alpha A crystallin
member entity reference: AGAP005548-PA
member entity reference: CRYAA isoform 1
member entity reference: Crystallin alpha B
member entity reference: AGAP007158-PA
member entity reference: Heat shock protein beta-2
member entity reference: alpha-crystallin A chain-like
member entity reference: CRYAB isoform 1
member entity reference: Alpha b crystallin
member entity reference: Heat shock protein family B (small) member 2
member entity reference: AGAP007161-PA
member entity reference: Heat shock 27kDa protein 2
member entity reference: AGAP005547-PA

Protein kinase C
type: ProteinReference
xref: uniprot E1BMG4 556
xref: PTHR24356:SF181
organism: Bos taurus

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P24723 603
organism: Homo sapiens

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot Q9WUD9 62
organism: Rattus norvegicus

uniprot A0A0G2K6E0 1203
type: UnificationXref
id: A0A0G2K6E0
db: uniprot

Cytosolic phospholipase A2
type: ProteinReference
xref: uniprot B1WAZ6 1180
organism: Xenopus tropicalis

Endothelial-specific receptor tyrosine kinase
type: ProteinReference
xref: uniprot D3ZCD0 1144
xref: PTHR24416:SF125
organism: Rattus norvegicus

Hypoxia inducible factor 1 subunit alpha
type: ProteinReference
xref: uniprot F1PZ54 499
xref: PTHR23043:SF7
organism: Canis lupus familiaris

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: PTHR23043:SF7
xref: uniprot O35800 502
organism: Rattus norvegicus

uniprot F6URW3 169
type: UnificationXref
id: F6URW3
db: uniprot

uniprot F1Q2Q5 1031
type: UnificationXref
id: F1Q2Q5
db: uniprot

Fos proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot E2QYK5 870
xref: PTHR23351:SF4
organism: Canis lupus familiaris

uniprot A7EEX6 1205
type: UnificationXref
id: A7EEX6
db: uniprot

FRS-2
type: Protein
entity reference: FRS-2
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot E2RTG8 335
type: UnificationXref
id: E2RTG8
db: uniprot

P00198
type: UnificationXref
id: P00198
db: PANTHER Pathway Component

P00199
type: UnificationXref
id: P00199
db: PANTHER Pathway Component

P00196
type: UnificationXref
id: P00196
db: PANTHER Pathway Component

P00197
type: UnificationXref
id: P00197
db: PANTHER Pathway Component

P00194
type: UnificationXref
id: P00194
db: PANTHER Pathway Component

P00195
type: UnificationXref
id: P00195
db: PANTHER Pathway Component

P00192
type: UnificationXref
id: P00192
db: PANTHER Pathway Component

uniprot Q7PT52 831
type: UnificationXref
id: Q7PT52
db: uniprot

P00193
type: UnificationXref
id: P00193
db: PANTHER Pathway Component

P00190
type: UnificationXref
id: P00190
db: PANTHER Pathway Component

uniprot P20936 147
type: UnificationXref
id: P20936
db: uniprot

P00191
type: UnificationXref
id: P00191
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Grb7-RIGHT__Grb7-_r263
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r263 1448
participant stoichiometry: PARTICIPANT STOICHIOMETRY r263 1449
left: Grb7
interaction type: STATE_TRANSITION
right: Grb7

uniprot Q9VZ44 763
type: UnificationXref
id: Q9VZ44
db: uniprot

uniprot F6T2E7 1158
type: UnificationXref
id: F6T2E7
db: uniprot

PARTICIPANT STOICHIOMETRY re113 1456
type: Stoichiometry
physical entity: Ang-1
stoichiometric coefficient: 1.0

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot H2QHR7 585
organism: Pan troglodytes

FGFR-1
type: Protein
entity reference: FGFR-1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7EI91 872
type: UnificationXref
id: F7EI91
db: uniprot

Fibroblast growth factor receptor 1
type: ProteinReference
xref: uniprot P21804 71
xref: PTHR24416:SF131
organism: Gallus gallus

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9WUA6 676
organism: Mus musculus

Delta-like protein
type: ProteinReference
xref: uniprot F7CZA9 731
organism: Xenopus tropicalis

PTHR48013:SF20
type: RelationshipXref
id: PTHR48013:SF20
db: PANTHER Family
relationship type: By Homology

uniprot F7H9J1 415
type: UnificationXref
id: F7H9J1
db: uniprot

PDGF
type: Protein
entity reference: PDGF
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa15 1291
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P08487 1280
type: UnificationXref
id: P08487
db: uniprot

uniprot F6WES5 686
type: UnificationXref
id: F6WES5
db: uniprot

uniprot Q3SYZ2 1103
type: UnificationXref
id: Q3SYZ2
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F7BVQ1 1278
xref: PTHR10336:SF25
organism: Monodelphis domestica

Growth factor receptor-bound protein 14
type: ProteinReference
xref: uniprot O88900 229
organism: Rattus norvegicus

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P14602 823
organism: Mus musculus

uniprot P55211 521
type: UnificationXref
id: P55211
db: uniprot

uniprot E1BQ32 395
type: UnificationXref
id: E1BQ32
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot E1C6T4 559
organism: Gallus gallus

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3SR38 549
xref: PTHR24356:SF181
organism: Pan troglodytes

uniprot P02504 819
type: UnificationXref
id: P02504
db: uniprot

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot F1PZ82 1093
organism: Canis lupus familiaris

uniprot Q00944 429
type: UnificationXref
id: Q00944
db: uniprot

Src
type: Protein
entity reference: Src
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot F6QM53 904
organism: Ornithorhynchus anatinus

uniprot P42224 536
type: UnificationXref
id: P42224
db: uniprot

uniprot E2QZ71 780
type: UnificationXref
id: E2QZ71
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A7STP5 988
organism: Nematostella vectensis

ncbitaxon 9258 68
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot J9NT83 1054
type: UnificationXref
id: J9NT83
db: uniprot

Axin
type: Protein
entity reference: Axin
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1LSD1 433
type: UnificationXref
id: A0A3Q1LSD1
db: uniprot

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot Q08E52 1169
xref: PTHR48015:SF20
organism: Bos taurus

uniprot A0A1D5QJY6 881
type: UnificationXref
id: A0A1D5QJY6
db: uniprot

Ras homolog family member B
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot Q6NVL3 1245
organism: Xenopus tropicalis

STATE_TRANSITION_LEFT__JNKK1-RIGHT__JNKK1-_r152
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r152 1497
participant stoichiometry: PARTICIPANT STOICHIOMETRY r152 1496
left: JNKK1
interaction type: STATE_TRANSITION
right: JNKK1

uniprot Q60823 672
type: UnificationXref
id: Q60823
db: uniprot

BAD
type: Protein
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: uniprot P20786 793
xref: PTHR24416:SF52
organism: Rattus norvegicus

uniprot G5EDY0 922
type: UnificationXref
id: G5EDY0
db: uniprot

Docking protein 2
type: ProteinReference
xref: uniprot O60496 14
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F7F5X1 1004
organism: Monodelphis domestica

uniprot P31938 706
type: UnificationXref
id: P31938
db: uniprot

GAP
type: Protein
entity reference: GAP
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6Y9I6 572
type: UnificationXref
id: F6Y9I6
db: uniprot

uniprot Q9XTG7 677
type: UnificationXref
id: Q9XTG7
db: uniprot

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: PTHR21258:SF40
xref: uniprot Q8C180 1056
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y6B5 1114
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Sck-RIGHT__Sck-_r287
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r287 1354
participant stoichiometry: PARTICIPANT STOICHIOMETRY r287 1353
left: Sck
interaction type: STATE_TRANSITION
right: Sck

uniprot H2RDH4 736
type: UnificationXref
id: H2RDH4
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot E2RCV1 895
xref: PTHR10048:SF34
organism: Canis lupus familiaris

Baculoviral IAP repeat-containing protein 5.1
type: ProteinReference
xref: uniprot Q28H51 235
organism: Xenopus tropicalis

uniprot F7HPR8 40
type: UnificationXref
id: F7HPR8
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q5F352 1022
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r288 1349
type: Stoichiometry
physical entity: Src
stoichiometric coefficient: 1.0

uniprot Q5M852 201
type: UnificationXref
id: Q5M852
db: uniprot

uniprot A6QLK6 856
type: UnificationXref
id: A6QLK6
db: uniprot

GAP
type: Protein
entity reference: GAP
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Frizzled class receptor 1
type: ProteinReference
xref: uniprot F7E9U1 124
xref: PTHR11309:SF81
organism: Monodelphis domestica

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: PTHR21258:SF40
xref: uniprot B5DE89 1047
organism: Xenopus tropicalis

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot H2QP14 1165
xref: PTHR48015:SF22
organism: Pan troglodytes

uniprot O93467 1219
type: UnificationXref
id: O93467
db: uniprot

uniprot F7ALW1 508
type: UnificationXref
id: F7ALW1
db: uniprot

Fibroblast growth factor 2
type: ProteinReference
xref: uniprot P13109 490
xref: PTHR11486:SF83
organism: Rattus norvegicus

uniprot P08642 1011
type: UnificationXref
id: P08642
db: uniprot

uniprot F6VWY6 301
type: UnificationXref
id: F6VWY6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F6R8N3 661
organism: Macaca mulatta

HIF1A isoform 7
type: ProteinReference
xref: uniprot H2Q8F3 501
xref: PTHR23043:SF7
organism: Pan troglodytes

Protein kinase C eta type
type: ProteinReference
xref: uniprot H2Q8F2 582
xref: PTHR24356:SF192
organism: Pan troglodytes

CRK like proto-oncogene, adaptor protein
type: ProteinReference
xref: PTHR19969:SF20
xref: uniprot F7E9T7 401
organism: Ornithorhynchus anatinus

uniprot H2QIW7 228
type: UnificationXref
id: H2QIW7
db: uniprot

PARTICIPANT STOICHIOMETRY re113 1457
type: Stoichiometry
physical entity: Ang-1
stoichiometric coefficient: 1.0

uniprot A0A2I3S4I6 1204
type: UnificationXref
id: A0A2I3S4I6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC_gamma-RIGHT__PLC_gamma-_r203
controller: Complex (PDGFR/PDGF)

Paxillin-B
type: ProteinReference
xref: uniprot Q8MML5 204
organism: Dictyostelium discoideum

PARTICIPANT STOICHIOMETRY r281 1376
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

ncbitaxon 13616 30
type: UnificationXref
id: 13616
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r281 1377
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

cPLA2 s52 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cPLA2
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q6P943 538
xref: PTHR11801:SF18
organism: Danio rerio

Eph receptor B3a
type: ProteinReference
xref: uniprot B8JKB8 459
organism: Danio rerio

Tie2
type: Protein
entity reference: Tie2
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q845 581
type: UnificationXref
id: H2Q845
db: uniprot

DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r284
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r284 1367
participant stoichiometry: PARTICIPANT STOICHIOMETRY r284 1365
participant stoichiometry: PARTICIPANT STOICHIOMETRY r284 1366
left: PIP2
interaction type: DISSOCIATION
right: IP3
right: DAG

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ELA0 467
xref: PTHR24416:SF120
organism: Macaca mulatta

uniprot O35462 1133
type: UnificationXref
id: O35462
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Tie2-_Ang_1-RIGHT__Complex__Tie2_Ang_1_-_r267
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r267 1445
participant stoichiometry: PARTICIPANT STOICHIOMETRY r267 1446
participant stoichiometry: PARTICIPANT STOICHIOMETRY r267 1447
left: Ang-1
left: Tie2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Tie2/Ang-1)

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Z879 242
xref: PTHR48013:SF15
organism: Monodelphis domestica

P00238
type: UnificationXref
id: P00238
db: PANTHER Pathway Component

P00237
type: UnificationXref
id: P00237
db: PANTHER Pathway Component

P00236
type: UnificationXref
id: P00236
db: PANTHER Pathway Component

P00235
type: UnificationXref
id: P00235
db: PANTHER Pathway Component

uniprot A5PMP7 682
type: UnificationXref
id: A5PMP7
db: uniprot

P00239
type: UnificationXref
id: P00239
db: PANTHER Pathway Component

P00240
type: UnificationXref
id: P00240
db: PANTHER Pathway Component

P00241
type: UnificationXref
id: P00241
db: PANTHER Pathway Component

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

P00244
type: UnificationXref
id: P00244
db: PANTHER Pathway Component

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

P00245
type: UnificationXref
id: P00245
db: PANTHER Pathway Component

Frizzled-3
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot F6QL95 119
organism: Macaca mulatta

P00242
type: UnificationXref
id: P00242
db: PANTHER Pathway Component

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7A632 573
organism: Monodelphis domestica

P00243
type: UnificationXref
id: P00243
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot A0A1D5QAU9 238
organism: Macaca mulatta

uniprot F1MAI3 164
type: UnificationXref
id: F1MAI3
db: uniprot

uniprot O54915 157
type: UnificationXref
id: O54915
db: uniprot

Baculoviral IAP repeat-containing protein 5
type: ProteinReference
xref: PTHR46771:SF3
xref: uniprot Q8I009 237
organism: Canis lupus familiaris

uniprot O14939 307
type: UnificationXref
id: O14939
db: uniprot

Rho GTPase activating protein 1
type: ProteinReference
xref: uniprot F6W5V4 1113
xref: PTHR45808:SF6
organism: Monodelphis domestica

P00225
type: UnificationXref
id: P00225
db: PANTHER Pathway Component

P00224
type: UnificationXref
id: P00224
db: PANTHER Pathway Component

Axin 2
type: ProteinReference
xref: PTHR46102:SF1
xref: uniprot K7CHS6 1194
organism: Pan troglodytes

P00227
type: UnificationXref
id: P00227
db: PANTHER Pathway Component

P00226
type: UnificationXref
id: P00226
db: PANTHER Pathway Component

P00229
type: UnificationXref
id: P00229
db: PANTHER Pathway Component

Growth factor receptor bound protein 7
type: ProteinReference
xref: PTHR11243:SF25
xref: uniprot E2QZ71 780
organism: Canis lupus familiaris

P00228
type: UnificationXref
id: P00228
db: PANTHER Pathway Component

uniprot P42336 944
type: UnificationXref
id: P42336
db: uniprot

ncbitaxon 665079 1206
type: UnificationXref
id: 665079
db: ncbitaxon

P00230
type: UnificationXref
id: P00230
db: PANTHER Pathway Component

P00231
type: UnificationXref
id: P00231
db: PANTHER Pathway Component

P00233
type: UnificationXref
id: P00233
db: PANTHER Pathway Component

uniprot F6T0E0 1112
type: UnificationXref
id: F6T0E0
db: uniprot

uniprot E2R9M9 114
type: UnificationXref
id: E2R9M9
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot H2R8U9 172
xref: PTHR23113:SF168
organism: Pan troglodytes

uniprot Q9DGE1 37
type: UnificationXref
id: Q9DGE1
db: uniprot

PARTICIPANT STOICHIOMETRY r256 1465
type: Stoichiometry
physical entity: eNOS
stoichiometric coefficient: 1.0

uniprot P31749 666
type: UnificationXref
id: P31749
db: uniprot

PARTICIPANT STOICHIOMETRY r256 1466
type: Stoichiometry
physical entity: Complex (eNOS/Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r256 1464
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HKP4 689
organism: Macaca mulatta

cPLA2
type: Protein
entity reference: cPLA2
feature: COMPLEX PARTICIPANT BINDING FEATURE s52 sa22 1293
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot E2RPB0 898
type: UnificationXref
id: E2RPB0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR21258:SF40
xref: uniprot F7F6D5 1052
organism: Monodelphis domestica

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot P27704 705
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r231 1538
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pak-RIGHT__Pak-_r269
controller: Nck

Uncharacterized protein
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot F7H9J1 415
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r231 1537
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

Ras homolog family member B
type: ProteinReference
xref: uniprot F7FR08 1215
xref: PTHR24072:SF0
organism: Ornithorhynchus anatinus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SHC-RIGHT__SHC-_r222
controller: Complex (FGFR-1/FGF)

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot F6PGQ1 444
organism: Monodelphis domestica

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot E2R186 66
xref: PTHR24416:SF131
organism: Canis lupus familiaris

P00247
type: UnificationXref
id: P00247
db: PANTHER Pathway Component

P00246
type: UnificationXref
id: P00246
db: PANTHER Pathway Component

P00249
type: UnificationXref
id: P00249
db: PANTHER Pathway Component

P00248
type: UnificationXref
id: P00248
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Pak-RIGHT__Pak-_r269
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r269 1436
participant stoichiometry: PARTICIPANT STOICHIOMETRY r269 1437
left: Pak
interaction type: STATE_TRANSITION
right: Pak

P00253
type: UnificationXref
id: P00253
db: PANTHER Pathway Component

P00254
type: UnificationXref
id: P00254
db: PANTHER Pathway Component

P00255
type: UnificationXref
id: P00255
db: PANTHER Pathway Component

P00256
type: UnificationXref
id: P00256
db: PANTHER Pathway Component

Catenin beta-1
type: ProteinReference
xref: uniprot Q9WU82 96
xref: PTHR45976:SF4
organism: Rattus norvegicus

P00250
type: UnificationXref
id: P00250
db: PANTHER Pathway Component

P00251
type: UnificationXref
id: P00251
db: PANTHER Pathway Component

uniprot F1N7C3 165
type: UnificationXref
id: F1N7C3
db: uniprot

P00252
type: UnificationXref
id: P00252
db: PANTHER Pathway Component

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q0IIE2 45
xref: PTHR10337:SF2
organism: Bos taurus

uniprot P97465 20
type: UnificationXref
id: P97465
db: uniprot

uniprot H2R1L6 304
type: UnificationXref
id: H2R1L6
db: uniprot

Neurogenic locus notch homolog protein 4
type: ProteinReference
xref: uniprot Q99466 1268
xref: PTHR24044:SF450
organism: Homo sapiens

uniprot Q02111 611
type: UnificationXref
id: Q02111
db: uniprot

Rho GTPase Activating protein
type: ProteinReference
xref: uniprot Q23130 1120
organism: Caenorhabditis elegans

ncbitaxon 9598 12
type: UnificationXref
id: 9598
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re106 1476
type: Stoichiometry
physical entity: Caspase 9
stoichiometric coefficient: 1.0

uniprot A0NBA9 889
type: UnificationXref
id: A0NBA9
db: uniprot

PARTICIPANT STOICHIOMETRY re106 1475
type: Stoichiometry
physical entity: Caspase 9
stoichiometric coefficient: 1.0

uniprot Q6P023 297
type: UnificationXref
id: Q6P023
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot O02812 31
organism: Canis lupus familiaris

uniprot E1BDN7 720
type: UnificationXref
id: E1BDN7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r280
controller: PKC

ACTIVE 25
type: EntityFeature
comment: Active state

Serine/threonine-protein kinase D3
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot O94806 589
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r291 1550
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r291 1551
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Complex__Tie2_Ang_1_-RIGHT__Complex__Tie2_Ang_1_-_re115
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re115 1451
participant stoichiometry: PARTICIPANT STOICHIOMETRY re115 1450
left: Complex (Tie2/Ang-1)
interaction type: STATE_TRANSITION
right: Complex (Tie2/Ang-1)

Uncharacterized protein rasC
type: ProteinReference
xref: uniprot F1A411 999
organism: Dictyostelium purpureum

uniprot Q9NRA1 703
type: UnificationXref
id: Q9NRA1
db: uniprot

PDGF
type: Protein
entity reference: PDGF
comment: SPECIES_TYPE=PROTEIN

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Complex__Tie2_Ang_1_-RIGHT__Complex__Tie2_Ang_1_-_re115
controller: VE-PTP

uniprot O70201 234
type: UnificationXref
id: O70201
db: uniprot

DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_r204
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r204 1435
participant stoichiometry: PARTICIPANT STOICHIOMETRY r204 1433
participant stoichiometry: PARTICIPANT STOICHIOMETRY r204 1434
left: PIP2
interaction type: DISSOCIATION
right: IP3
right: DAG

Platelet derived growth factor C
type: ProteinReference
xref: uniprot F1PGJ9 685
organism: Canis lupus familiaris

uniprot F7G756 733
type: UnificationXref
id: F7G756
db: uniprot

FGF
type: Protein
entity reference: FGF
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q61532 711
organism: Mus musculus

uniprot A0A1D5R999 805
type: UnificationXref
id: A0A1D5R999
db: uniprot

PTHR19143:SF156
type: RelationshipXref
id: PTHR19143:SF156
db: PANTHER Family
relationship type: By Homology

uniprot H2R8L2 41
type: UnificationXref
id: H2R8L2
db: uniprot

uniprot Q7QK56 673
type: UnificationXref
id: Q7QK56
db: uniprot

uniprot F7BXC9 846
type: UnificationXref
id: F7BXC9
db: uniprot

Phospholipase
type: ProteinReference
xref: uniprot F7FFF4 302
xref: PTHR18896:SF57
organism: Macaca mulatta

uniprot F7DUD6 915
type: UnificationXref
id: F7DUD6
db: uniprot

uniprot F1M7Y5 564
type: UnificationXref
id: F1M7Y5
db: uniprot

uniprot F7GD33 510
type: UnificationXref
id: F7GD33
db: uniprot

uniprot Q6NUX8 1244
type: UnificationXref
id: Q6NUX8
db: uniprot

uniprot F7G4Q4 1130
type: UnificationXref
id: F7G4Q4
db: uniprot

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

LPXN isoform 3
type: ProteinReference
xref: uniprot A0A2I3TSS9 189
organism: Pan troglodytes

FBJ murine osteosarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot F7EI91 872
xref: PTHR23351:SF4
organism: Xenopus tropicalis

uniprot F7FH70 104
type: UnificationXref
id: F7FH70
db: uniprot

PTHR46221:SF5
type: RelationshipXref
id: PTHR46221:SF5
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR19143:SF199
xref: uniprot F6QXG9 1128
organism: Macaca mulatta

uniprot O75914 1166
type: UnificationXref
id: O75914
db: uniprot

Vascular endothelial growth factor receptor kdr-like
type: ProteinReference
xref: uniprot Q8AXB3 640
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot F7CS91 1213
organism: Monodelphis domestica

Evidence 866
type: Evidence
evidence code: ISS
comment: Website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd

uniprot Q9WTQ0 631
type: UnificationXref
id: Q9WTQ0
db: uniprot

uniprot D3ZB71 249
type: UnificationXref
id: D3ZB71
db: uniprot

uniprot P61586 1226
type: UnificationXref
id: P61586
db: uniprot

Paxillin
type: ProteinReference
xref: P00194
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Paxillin Synonym: PXN Accession: P00194
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Paxillin
member entity reference: Paxillin, isoform F
member entity reference: GH01042p
member entity reference: Paxillin-B
member entity reference: Transforming growth factor beta 1 induced transcript 1
member entity reference: Paxillin
member entity reference: Transforming growth factor beta-1-induced transcript 1 protein
member entity reference: PXN isoform 9
member entity reference: Protein CBR-PXL-1
member entity reference: Leupaxin
member entity reference: Uncharacterized protein
member entity reference: Leupaxin isoform 2
member entity reference: LIM domain-containing protein B
member entity reference: LPXN isoform 3

Uncharacterized protein
type: ProteinReference
xref: PTHR23043:SF7
xref: uniprot F7HKJ2 500
organism: Macaca mulatta

uniprot Q7QEJ7 961
type: UnificationXref
id: Q7QEJ7
db: uniprot

uniprot F6VG66 1129
type: UnificationXref
id: F6VG66
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5QUZ8 281
xref: PTHR24055:SF203
organism: Macaca mulatta

Leupaxin isoform 2
type: ProteinReference
xref: uniprot A0A1D5Q8X5 185
organism: Macaca mulatta

uniprot Q8INB9 674
type: UnificationXref
id: Q8INB9
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q9WTQ0 631
xref: PTHR24356:SF181
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot P16885 1282
xref: PTHR10336:SF25
organism: Homo sapiens

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 180

uniprot P51140 262
type: UnificationXref
id: P51140
db: uniprot

ncbitaxon 7227 57
type: UnificationXref
id: 7227
db: ncbitaxon

Angiopoietin-1 receptor
type: ProteinReference
xref: PTHR24416:SF125
xref: uniprot Q02858 1149
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r252 1481
type: Stoichiometry
physical entity: JAK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r252 1482
type: Stoichiometry
physical entity: JAK1
stoichiometric coefficient: 1.0

uniprot F7EZV2 10
type: UnificationXref
id: F7EZV2
db: uniprot

ncbitaxon 7955 38
type: UnificationXref
id: 7955
db: ncbitaxon

c Fos s17 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: c-Fos
stoichiometric coefficient: 1.0

Platelet-derived growth factor A chain long form
type: ProteinReference
xref: uniprot Q90WK2 698
organism: Gallus gallus

Rho-GTPase-activating protein 8
type: ProteinReference
xref: uniprot Q6AYD8 1123
organism: Rattus norvegicus

uniprot P29355 859
type: UnificationXref
id: P29355
db: uniprot

uniprot A4IFC0 681
type: UnificationXref
id: A4IFC0
db: uniprot

uniprot P28465 369
type: UnificationXref
id: P28465
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A1D5QLW6 1270
xref: PTHR10336:SF25
organism: Macaca mulatta

uniprot P05126 590
type: UnificationXref
id: P05126
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: uniprot Q05513 615
xref: PTHR24356:SF170
organism: Homo sapiens

uniprot P05130 593
type: UnificationXref
id: P05130
db: uniprot

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot Q04982 1088
organism: Gallus gallus

uniprot A0A2I3TN25 680
type: UnificationXref
id: A0A2I3TN25
db: uniprot

uniprot Q61036 1173
type: UnificationXref
id: Q61036
db: uniprot

Ets
type: Protein
entity reference: Ets
feature: ACTIVE 25
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P17252 600
xref: PTHR24356:SF193
organism: Homo sapiens

uniprot P70498 309
type: UnificationXref
id: P70498
db: uniprot

uniprot A0A1D5R3Z3 837
type: UnificationXref
id: A0A1D5R3Z3
db: uniprot

HIF-1
type: Protein
entity reference: HIF-1
feature: ACTIVE 25
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

Phospholipase A2
type: ProteinReference
xref: uniprot F7HAE1 1182
organism: Macaca mulatta

RCG53912, isoform CRA_a
type: ProteinReference
xref: uniprot Q6AYB2 800
organism: Rattus norvegicus

uniprot A0A1D5QEP8 1254
type: UnificationXref
id: A0A1D5QEP8
db: uniprot

P00201
type: UnificationXref
id: P00201
db: PANTHER Pathway Component

uniprot Q62925 419
type: UnificationXref
id: Q62925
db: uniprot

P00200
type: UnificationXref
id: P00200
db: PANTHER Pathway Component

eco ECO:0000250 18
type: UnificationXref
id: ECO:0000250
db: eco

STATE_TRANSITION
type: InteractionVocabulary

Kinase insert domain receptor
type: ProteinReference
xref: uniprot Q2XPT7 639
xref: PTHR24416:SF45
organism: Canis lupus familiaris

TRANSPORT
type: InteractionVocabulary

uniprot P48614 374
type: UnificationXref
id: P48614
db: uniprot

uniprot F7BRK5 1077
type: UnificationXref
id: F7BRK5
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q16539 35
xref: PTHR24055:SF110
organism: Homo sapiens

PLD
type: ProteinReference
xref: P00204
standard name: Phospholipase D
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phospholipase D Synonym: Synonym not specified Accession: P00204
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.PLD
member entity reference: Phospholipase D2
member entity reference: Phospholipase
member entity reference: AGAP010687-PA (Fragment)
member entity reference: Phospholipase D1

RAS p21 protein activator 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot E9PYG6 142
organism: Mus musculus

uniprot P04049 1079
type: UnificationXref
id: P04049
db: uniprot

uniprot A7YY44 156
type: UnificationXref
id: A7YY44
db: uniprot

uniprot Q95YD4 431
type: UnificationXref
id: Q95YD4
db: uniprot

PARTICIPANT STOICHIOMETRY r295 1539
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PTHR10155:SF10
type: RelationshipXref
id: PTHR10155:SF10
db: PANTHER Family
relationship type: By Homology

Phospholipase A2
type: ProteinReference
xref: PTHR10728:SF32
xref: uniprot F7HAF3 771
organism: Macaca mulatta

Tyrosine-protein kinase JAK1
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot O12990 81
organism: Danio rerio

uniprot F1PZ82 1093
type: UnificationXref
id: F1PZ82
db: uniprot

STATE_TRANSITION_LEFT__JAK1-RIGHT__JAK1-_r179
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r179 1404
participant stoichiometry: PARTICIPANT STOICHIOMETRY r179 1405
left: JAK1
interaction type: STATE_TRANSITION
right: JAK1

PARTICIPANT STOICHIOMETRY r295 1540
type: Stoichiometry
physical entity: eNOS
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase D1
type: ProteinReference
xref: uniprot Q62101 623
xref: PTHR22968:SF9
organism: Mus musculus

EFNB2 isoform 1
type: ProteinReference
xref: PTHR11304:SF18
xref: uniprot H2Q7S4 1035
organism: Pan troglodytes

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot H2Q845 581
xref: PTHR22968:SF9
organism: Pan troglodytes

GTP-binding protein RHO1
type: ProteinReference
xref: uniprot P06780 1221
organism: Saccharomyces cerevisiae

P00221
type: UnificationXref
id: P00221
db: PANTHER Pathway Component

P00220
type: UnificationXref
id: P00220
db: PANTHER Pathway Component

P00223
type: UnificationXref
id: P00223
db: PANTHER Pathway Component

P00222
type: UnificationXref
id: P00222
db: PANTHER Pathway Component

Ephrin type-B receptor 1
type: ProteinReference
xref: uniprot Q8CBF3 483
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r295 1541
type: Stoichiometry
physical entity: Complex (eNOS/Ca2+
stoichiometric coefficient: 1.0

Paxillin
type: ProteinReference
xref: uniprot Q8VI36 206
xref: PTHR24216:SF11
organism: Mus musculus

uniprot P09759 472
type: UnificationXref
id: P09759
db: uniprot

P00217
type: UnificationXref
id: P00217
db: PANTHER Pathway Component

P00218
type: UnificationXref
id: P00218
db: PANTHER Pathway Component

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s53 sa23 1295
cellular location: plasma membrane
comment: SPECIES_TYPE=ION

P00219
type: UnificationXref
id: P00219
db: PANTHER Pathway Component

P00213
type: UnificationXref
id: P00213
db: PANTHER Pathway Component

uniprot P26675 175
type: UnificationXref
id: P26675
db: uniprot

P00214
type: UnificationXref
id: P00214
db: PANTHER Pathway Component

uniprot F7EEZ1 770
type: UnificationXref
id: F7EEZ1
db: uniprot

P00215
type: UnificationXref
id: P00215
db: PANTHER Pathway Component

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot O46404 935
organism: Bos taurus

P00216
type: UnificationXref
id: P00216
db: PANTHER Pathway Component

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XUP1 1160
xref: PTHR48015:SF20
organism: Macaca mulatta

uniprot F6W7C8 910
type: UnificationXref
id: F6W7C8
db: uniprot

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot E2RHV6 506
organism: Canis lupus familiaris

uniprot A0A0G2JZW4 209
type: UnificationXref
id: A0A0G2JZW4
db: uniprot

P00212
type: UnificationXref
id: P00212
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot B3RIM6 1209
organism: Trichoplax adhaerens

P00211
type: UnificationXref
id: P00211
db: PANTHER Pathway Component

P00210
type: UnificationXref
id: P00210
db: PANTHER Pathway Component

MEKK1
type: Protein
entity reference: MEKK1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P45983 648
type: UnificationXref
id: P45983
db: uniprot

uniprot H2Q569 349
type: UnificationXref
id: H2Q569
db: uniprot

uniprot Q63789 955
type: UnificationXref
id: Q63789
db: uniprot

P00208
type: UnificationXref
id: P00208
db: PANTHER Pathway Component

P00209
type: UnificationXref
id: P00209
db: PANTHER Pathway Component

P00206
type: UnificationXref
id: P00206
db: PANTHER Pathway Component

P00207
type: UnificationXref
id: P00207
db: PANTHER Pathway Component

P00204
type: UnificationXref
id: P00204
db: PANTHER Pathway Component

P00205
type: UnificationXref
id: P00205
db: PANTHER Pathway Component

P00202
type: UnificationXref
id: P00202
db: PANTHER Pathway Component

P00203
type: UnificationXref
id: P00203
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Survivin-RIGHT__Survivin-_r255
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r255 1470
participant stoichiometry: PARTICIPANT STOICHIOMETRY r255 1469
left: Survivin
interaction type: STATE_TRANSITION
right: Survivin

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RasGAP-RIGHT__RasGAP-_r274
controller: Dok-R

uniprot P52795 1037
type: UnificationXref
id: P52795
db: uniprot

PTHR24044:SF308
type: RelationshipXref
id: PTHR24044:SF308
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r285 1362
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

uniprot O08908 933
type: UnificationXref
id: O08908
db: uniprot

PARTICIPANT STOICHIOMETRY r285 1361
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

Dsh
type: Protein
entity reference: Dsh
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

EPH receptor A3
type: ProteinReference
xref: uniprot H2QMY7 470
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E1BS97 1153
xref: PTHR48015:SF22
organism: Gallus gallus

uniprot P36507 708
type: UnificationXref
id: P36507
db: uniprot

uniprot Q7L591 22
type: UnificationXref
id: Q7L591
db: uniprot

STATE_TRANSITION_LEFT__c_Jun-RIGHT__c_Jun-_r248
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r248 1503
participant stoichiometry: PARTICIPANT STOICHIOMETRY r248 1504
left: c-Jun
interaction type: STATE_TRANSITION
right: c-Jun

uniprot F7E9U1 124
type: UnificationXref
id: F7E9U1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__STAT3-RIGHT__STAT3-_r254
controller: JAK1

Caspase-9
type: ProteinReference
xref: uniprot P55211 521
xref: PTHR10454:SF157
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r205
controller: DAG

uniprot Q5XIS9 621
type: UnificationXref
id: Q5XIS9
db: uniprot

Tie2
type: Protein
entity reference: Tie2
feature: COMPLEX PARTICIPANT BINDING FEATURE s225 sa20 1301
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Growth factor receptor-bound protein 7
type: ProteinReference
xref: PTHR11243:SF25
xref: uniprot Q03160 782
organism: Mus musculus

Docking protein 2
type: ProteinReference
xref: uniprot O70469 16
xref: PTHR21258:SF14
organism: Mus musculus

uniprot P98077 279
type: UnificationXref
id: P98077
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P28482 293
organism: Homo sapiens

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: uniprot Q16644 1102
xref: PTHR24349:SF64
organism: Homo sapiens

Predicted protein
type: ProteinReference
xref: uniprot A7S9Y5 1207
organism: Nematostella vectensis

PTHR24044:SF421
type: RelationshipXref
id: PTHR24044:SF421
db: PANTHER Family
relationship type: By Homology

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot P49071 1099
organism: Drosophila melanogaster

DAG
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A2I3RZH3 1143
type: UnificationXref
id: A0A2I3RZH3
db: uniprot

PIP3
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7GEA7 688
type: UnificationXref
id: F7GEA7
db: uniprot

uniprot A0A2J8LQ70 322
type: UnificationXref
id: A0A2J8LQ70
db: uniprot

PDGFC isoform 1
type: ProteinReference
xref: uniprot A0A2I3TN25 680
organism: Pan troglodytes

uniprot F7GJG7 858
type: UnificationXref
id: F7GJG7
db: uniprot

Frizzled-3
type: ProteinReference
xref: PTHR11309:SF99
xref: uniprot O77438 130
organism: Drosophila melanogaster

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: PTHR21258:SF40
xref: uniprot A0A2I3TN31 1045
organism: Pan troglodytes

uniprot Q1LWR7 1136
type: UnificationXref
id: Q1LWR7
db: uniprot

GO GO:0031965 3
type: UnificationXref
id: GO:0031965
db: GO

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: uniprot F1MBU9 900
xref: PTHR10048:SF30
organism: Bos taurus

uniprot Q7QGY2 753
type: UnificationXref
id: Q7QGY2
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q8NEB9 963
organism: Homo sapiens

uniprot P08556 1010
type: UnificationXref
id: P08556
db: uniprot

FGF
type: ProteinReference
xref: P00213
standard name: Fibroblast Growth Factor
comment: ENTITY_REFERENCE_NOTES=Long Name: Fibroblast Growth Factor Synonym: ECGF,Endothelial Cell Growth Factor,HBGF,Heparin-Binding Growth Factor Accession: P00213
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.FGF
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Fibroblast growth factor 1
member entity reference: Fibroblast growth factor 2
member entity reference: Multifunctional fusion protein
member entity reference: Fibroblast growth factor

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P27361 292
xref: PTHR24055:SF393
organism: Homo sapiens

uniprot P09615 362
type: UnificationXref
id: P09615
db: uniprot

Caspase 9
type: Protein
entity reference: Caspase 9
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Delta-like protein 1
type: ProteinReference
xref: uniprot P97677 747
xref: PTHR24044:SF380
organism: Rattus norvegicus

uniprot G3V7U3 348
type: UnificationXref
id: G3V7U3
db: uniprot

uniprot P97677 747
type: UnificationXref
id: P97677
db: uniprot

uniprot Q28GC2 95
type: UnificationXref
id: Q28GC2
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF12
xref: uniprot F1MIA2 566
organism: Bos taurus

Protein Wnt
type: ProteinReference
xref: uniprot A0A1D5R803 319
xref: PTHR12027:SF73
organism: Macaca mulatta

uniprot Q7K3H0 958
type: UnificationXref
id: Q7K3H0
db: uniprot

Phospholipase
type: ProteinReference
xref: PTHR18896:SF57
xref: uniprot J9P1D8 305
organism: Canis lupus familiaris

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q01986 709
organism: Rattus norvegicus

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: uniprot Q16665 503
xref: PTHR23043:SF7
organism: Homo sapiens

RSA-14-44 protein
type: ProteinReference
xref: uniprot Q5XIM3 1237
organism: Rattus norvegicus

Complex (cPLA2_endsub/Ca2+_endsuper)
type: Complex
component stoichiometry: cPLA2 s52 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s53 sa23 STOICHIOMETRY ID COMPLEX
component: Ca2+
component: cPLA2
feature: COMPLEX BINDING FEATURE s203 a280 1294
feature: COMPLEX BINDING FEATURE s203 a280 1292
cellular location: plasma membrane

uniprot Q16539 35
type: UnificationXref
id: Q16539
db: uniprot

uniprot H2QCA7 243
type: UnificationXref
id: H2QCA7
db: uniprot

uniprot F1NHL1 569
type: UnificationXref
id: F1NHL1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r281
controller: SPK

PTHR19143:SF199
type: RelationshipXref
id: PTHR19143:SF199
db: PANTHER Family
relationship type: By Homology

Sphingosine kinase 2
type: ProteinReference
xref: uniprot Q9JIA7 802
organism: Mus musculus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re105
control type: ACTIVATION
controller: Akt

Phosphatidylinositol 3-kinase piki-1
type: ProteinReference
xref: uniprot G5EDY0 922
organism: Caenorhabditis elegans

TRANSPORT_LEFT__IP3-RIGHT__IP3-_r299
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r299 1525
participant stoichiometry: PARTICIPANT STOICHIOMETRY r299 1526
left: IP3
interaction type: TRANSPORT
right: IP3

uniprot P24383 367
type: UnificationXref
id: P24383
db: uniprot

uniprot A0A1D5R8E9 1271
type: UnificationXref
id: A0A1D5R8E9
db: uniprot

Protein kinase C-like 1B
type: ProteinReference
xref: uniprot P34885 606
organism: Caenorhabditis elegans

Ang 1 s226 sa236 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ang-1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SHC-RIGHT__SHC-_r222
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r222 1355
participant stoichiometry: PARTICIPANT STOICHIOMETRY r222 1356
left: SHC
interaction type: STATE_TRANSITION
right: SHC

Platelet-derived growth factor receptor beta
type: ProteinReference
xref: uniprot Q6QNF3 796
xref: PTHR24416:SF53
organism: Canis lupus familiaris

VEGFR 2 s56 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VEGFR-2
stoichiometric coefficient: 1.0

uniprot F6QL95 119
type: UnificationXref
id: F6QL95
db: uniprot

uniprot F7E313 635
type: UnificationXref
id: F7E313
db: uniprot

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot O70421 129
organism: Mus musculus

uniprot G5E577 704
type: UnificationXref
id: G5E577
db: uniprot

uniprot A0A1D5QZ44 5
type: UnificationXref
id: A0A1D5QZ44
db: uniprot

uniprot Q61062 269
type: UnificationXref
id: Q61062
db: uniprot

uniprot P04792 822
type: UnificationXref
id: P04792
db: uniprot

uniprot Q2IBD1 377
type: UnificationXref
id: Q2IBD1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RPB0 898
xref: PTHR10155:SF2
organism: Canis lupus familiaris

uniprot A0A2I3TK00 1072
type: UnificationXref
id: A0A2I3TK00
db: uniprot

uniprot Q9DGE2 39
type: UnificationXref
id: Q9DGE2
db: uniprot

NRAS isoform 1
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot H2PZQ7 1005
organism: Pan troglodytes

uniprot P15692 1060
type: UnificationXref
id: P15692
db: uniprot

Protein CBR-RHO-1
type: ProteinReference
xref: uniprot A8XIF5 1208
organism: Caenorhabditis briggsae

Protein Wnt-1
type: ProteinReference
xref: uniprot P24257 366
xref: PTHR12027:SF91
organism: Danio rerio

uniprot D4A5Q1 893
type: UnificationXref
id: D4A5Q1
db: uniprot

uniprot H2Q8F3 501
type: UnificationXref
id: H2Q8F3
db: uniprot

Protein Wnt-2
type: ProteinReference
xref: uniprot P34889 371
xref: PTHR12027:SF77
organism: Caenorhabditis elegans

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q64143 956
organism: Mus musculus

AGAP007161-PA
type: ProteinReference
xref: uniprot Q7PT52 831
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: PTHR19143:SF156
xref: uniprot F7F3F4 1139
organism: Macaca mulatta

uniprot P16234 792
type: UnificationXref
id: P16234
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 296
organism: Mus musculus

GRB7 isoform 1
type: ProteinReference
xref: PTHR11243:SF25
xref: uniprot A0A2I3S3A1 779
organism: Pan troglodytes

Phospholipase
type: ProteinReference
xref: uniprot G5EDU3 303
organism: Caenorhabditis elegans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNKK1-RIGHT__JNKK1-_r245
controller: MEKK1

STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_re108
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re108 1468
participant stoichiometry: PARTICIPANT STOICHIOMETRY re108 1467
left: Caspase 9
interaction type: STATE_TRANSITION
right: Caspase 9

uniprot O88900 229
type: UnificationXref
id: O88900
db: uniprot

STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_re106
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re106 1475
participant stoichiometry: PARTICIPANT STOICHIOMETRY re106 1476
left: Caspase 9
interaction type: STATE_TRANSITION
right: Caspase 9

uniprot A0A2J8JA34 716
type: UnificationXref
id: A0A2J8JA34
db: uniprot

uniprot Q5F352 1022
type: UnificationXref
id: Q5F352
db: uniprot

uniprot F1P241 397
type: UnificationXref
id: F1P241
db: uniprot

uniprot D3ZVF3 892
type: UnificationXref
id: D3ZVF3
db: uniprot

STAT3
type: Protein
entity reference: STAT3
feature: ACTIVE 25
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

MAPKAPK3 isoform 1
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot H2QMP5 1098
organism: Pan troglodytes

uniprot F6RSC1 788
type: UnificationXref
id: F6RSC1
db: uniprot

uniprot P10041 743
type: UnificationXref
id: P10041
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E1C3P6 1154
xref: PTHR48015:SF20
organism: Gallus gallus

eNOS
type: Protein
entity reference: eNOS
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r297 1532
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Docking protein 3
type: ProteinReference
xref: uniprot Q9QZK7 24
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r297 1531
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r233 1529
type: Stoichiometry
physical entity: Erk
stoichiometric coefficient: 1.0

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F7BWW9 171
organism: Ornithorhynchus anatinus

Catenin beta-1
type: ProteinReference
xref: uniprot B6V8E6 84
xref: PTHR45976:SF4
organism: Canis lupus familiaris

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Ang_1-RIGHT__Ang_1-_re113
control type: INHIBITION
controller: Ang-2

Fibroblast growth factor receptor substrate 3
type: ProteinReference
xref: uniprot Q91WJ0 1058
organism: Mus musculus

uniprot F1NE37 684
type: UnificationXref
id: F1NE37
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: uniprot Q62074 622
xref: PTHR24356:SF214
organism: Mus musculus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot Q7Q5D3 60
organism: Anopheles gambiae

Leupaxin
type: ProteinReference
xref: uniprot Q99N69 207
organism: Mus musculus

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot Q62077 1285
organism: Mus musculus

Catenin beta-1
type: ProteinReference
xref: uniprot F7GNE4 89
xref: PTHR45976:SF4
organism: Macaca mulatta

uniprot A0A3Q3ACS4 888
type: UnificationXref
id: A0A3Q3ACS4
db: uniprot

PARTICIPANT STOICHIOMETRY r233 1530
type: Stoichiometry
physical entity: Erk
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 290
organism: Pan troglodytes

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot Q60631 864
xref: PTHR46037:SF4
organism: Mus musculus

Coagulation factor VII
type: ProteinReference
xref: PTHR24278:SF26
xref: uniprot P70375 277
organism: Mus musculus

INHIBITION
type: Control
xref: INHIBITION
control type: INHIBITION
controller: FRP

DOK2 isoform 1
type: ProteinReference
xref: uniprot H2QVU0 13
organism: Pan troglodytes

uniprot F1MYJ4 657
type: UnificationXref
id: F1MYJ4
db: uniprot

uniprot Q90Y54 755
type: UnificationXref
id: Q90Y54
db: uniprot

uniprot Q8CI19 697
type: UnificationXref
id: Q8CI19
db: uniprot

Frizzled class receptor 5
type: ProteinReference
xref: PTHR11309:SF141
xref: uniprot F6QAW3 118
organism: Xenopus tropicalis

DISSOCIATION
type: RelationshipTypeVocabulary

Notch 1
type: ProteinReference
xref: uniprot F1PDC7 1256
xref: PTHR24033:SF176
organism: Canis lupus familiaris

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot K7CBH8 587
organism: Pan troglodytes

uniprot P09215 595
type: UnificationXref
id: P09215
db: uniprot

PTHR44329:SF55
type: RelationshipXref
id: PTHR44329:SF55
db: PANTHER Family
relationship type: By Homology

uniprot E1B7I9 1048
type: UnificationXref
id: E1B7I9
db: uniprot

uniprot Q7PCM8 830
type: UnificationXref
id: Q7PCM8
db: uniprot

uniprot P27361 292
type: UnificationXref
id: P27361
db: uniprot

uniprot Q61532 711
type: UnificationXref
id: Q61532
db: uniprot

PTHR44329:SF47
type: RelationshipXref
id: PTHR44329:SF47
db: PANTHER Family
relationship type: By Homology

uniprot Q64GA5 1186
type: UnificationXref
id: Q64GA5
db: uniprot

Crk-like protein
type: ProteinReference
xref: uniprot P46109 404
xref: PTHR19969:SF20
organism: Homo sapiens

Adapter molecule crk
type: ProteinReference
xref: uniprot P46108 403
xref: PTHR19969:SF8
organism: Homo sapiens

uniprot A8XBU1 423
type: UnificationXref
id: A8XBU1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A4FV00 644
organism: Bos taurus

Wnt
type: Protein
entity reference: Wnt
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa7 1309
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F1PIY7 77
type: UnificationXref
id: F1PIY7
db: uniprot

uniprot H2R0G7 647
type: UnificationXref
id: H2R0G7
db: uniprot

uniprot O88643 1167
type: UnificationXref
id: O88643
db: uniprot

Paxillin
type: ProteinReference
xref: uniprot P49023 196
xref: PTHR24216:SF11
organism: Homo sapiens

uniprot Q07890 178
type: UnificationXref
id: Q07890
db: uniprot

Paxillin
type: ProteinReference
xref: uniprot P49024 197
xref: PTHR24216:SF11
organism: Gallus gallus

PIK3C2A isoform 5
type: ProteinReference
xref: uniprot H2Q383 925
xref: PTHR10048:SF28
organism: Pan troglodytes

uniprot H2Q7S4 1035
type: UnificationXref
id: H2Q7S4
db: uniprot

Recombination signal-binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: uniprot M0R7Q3 847
xref: PTHR10665:SF3
organism: Rattus norvegicus

ncbitaxon 284811 1251
type: UnificationXref
id: 284811
db: ncbitaxon

Protein kinase C eta type
type: ProteinReference
xref: uniprot F1MY82 567
xref: PTHR24356:SF192
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q2U4X3 654
xref: PTHR24356:SF171
organism: Gallus gallus

PKC
type: ProteinReference
xref: P00219
standard name: Protein kinase B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.PKC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein Kinase C Synonym: Synonym not specified Accession: P00219
member entity reference: Protein kinase C
member entity reference: Serine/threonine-protein kinase D3
member entity reference: Serine/threonine-protein kinase D2
member entity reference: Protein kinase C-like 3
member entity reference: Serine/threonine-protein kinase
member entity reference: AGAP012252-PA (Fragment)
member entity reference: Protein kinase C zeta type
member entity reference: Protein kinase C delta type
member entity reference: Serine/threonine-protein kinase D1
member entity reference: Protein kinase C iota type
member entity reference: Protein kinase C-like 1
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C, brain isozyme
member entity reference: Protein kinase C-like 1B
member entity reference: Protein kinase C eta type
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C gamma type (Fragment)
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C theta type
member entity reference: Protein kinase C, eye isozyme
member entity reference: Serine/threonine-protein kinase dkf-2

Grb7
type: ProteinReference
xref: P00228
standard name: Growth Factor Receptor-Bound Protein 7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Growth Factor Receptor-Bound Protein 7 Synonym: Adaptor Protein 7 Accession: P00228
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Grb7
member entity reference: Growth factor receptor-bound protein 7
member entity reference: GRB7 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Growth factor receptor bound protein 7

uniprot A0A3Q1N9F5 551
type: UnificationXref
id: A0A3Q1N9F5
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot H2QDQ1 584
organism: Pan troglodytes

Angiopoietin 1
type: ProteinReference
xref: uniprot Q1MT43 1142
organism: Danio rerio

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor 1
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot P19596 492
organism: Gallus gallus

Secreted frizzled-related protein 3
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot F7BWZ1 974
organism: Macaca mulatta

uniprot Q9VTU3 1126
type: UnificationXref
id: Q9VTU3
db: uniprot

ANGPT2 isoform 1
type: ProteinReference
xref: PTHR19143:SF199
xref: uniprot H2QVQ1 1131
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r155 1489
type: Stoichiometry
physical entity: c-Fos
stoichiometric coefficient: 1.0

uniprot P34889 371
type: UnificationXref
id: P34889
db: uniprot

TCF
type: Protein
entity reference: TCF
feature: ACTIVE 25
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein rasD
type: ProteinReference
xref: uniprot F0ZB76 994
organism: Dictyostelium purpureum

PTHR11486:SF86
type: RelationshipXref
id: PTHR11486:SF86
db: PANTHER Family
relationship type: By Homology

uniprot Q08E52 1169
type: UnificationXref
id: Q08E52
db: uniprot

uniprot F6VAQ8 908
type: UnificationXref
id: F6VAQ8
db: uniprot

uniprot Q9NYA1 804
type: UnificationXref
id: Q9NYA1
db: uniprot

uniprot E2R7K2 252
type: UnificationXref
id: E2R7K2
db: uniprot

PARTICIPANT STOICHIOMETRY r155 1491
type: Stoichiometry
physical entity: Complex (c-Jun/c-Fos)
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot F6PX17 1094
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r155 1490
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

Multifunctional fusion protein
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot F6WG78 486
organism: Ornithorhynchus anatinus

Protein Wnt-5
type: ProteinReference
xref: uniprot P28466 370
xref: PTHR12027:SF77
organism: Drosophila melanogaster

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF112
xref: uniprot P28465 369
organism: Drosophila melanogaster

uniprot F1P859 166
type: UnificationXref
id: F1P859
db: uniprot

PARTICIPANT STOICHIOMETRY r296 1535
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r296 1536
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r280
controller: Ras

PTHR11486:SF83
type: RelationshipXref
id: PTHR11486:SF83
db: PANTHER Family
relationship type: By Homology

Eph receptor B2
type: ProteinReference
xref: uniprot A0A0G2JY48 456
xref: PTHR24416:SF123
organism: Rattus norvegicus

Heat shock 27kDa protein 2
type: ProteinReference
xref: uniprot F1MBR1 810
organism: Bos taurus

uniprot P47811 33
type: UnificationXref
id: P47811
db: uniprot

uniprot P11346 1084
type: UnificationXref
id: P11346
db: uniprot

uniprot P49138 1101
type: UnificationXref
id: P49138
db: uniprot

ncbitaxon 44689 180
type: UnificationXref
id: 44689
db: ncbitaxon

Nitric oxide synthase, endothelial
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot P70313 437
organism: Mus musculus

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: uniprot F6Z0J4 912
xref: PTHR10155:SF3
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r260 1458
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

Ras-like GTP-binding protein rhoA
type: ProteinReference
xref: uniprot Q22038 1233
organism: Caenorhabditis elegans

uniprot Q90XF2 629
type: UnificationXref
id: Q90XF2
db: uniprot

uniprot A0A3Q1MSZ4 247
type: UnificationXref
id: A0A3Q1MSZ4
db: uniprot

Cytoplasmic protein NCK2
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot O55033 514
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F7GEK1 664
organism: Monodelphis domestica

uniprot Q9IAT6 757
type: UnificationXref
id: Q9IAT6
db: uniprot

uniprot Q19266 619
type: UnificationXref
id: Q19266
db: uniprot

Protein Wnt-7a
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot O00755 357
organism: Homo sapiens

uniprot Q6NVL3 1245
type: UnificationXref
id: Q6NVL3
db: uniprot

Tie2 s225 sa235 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tie2
stoichiometric coefficient: 1.0

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P18870 545
organism: Gallus gallus

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s209 sa27 1329
cellular location: plasma membrane
comment: SPECIES_TYPE=ION

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TCF-RIGHT__TCF-_r189
controller: beta catenin

PARTICIPANT STOICHIOMETRY r260 1459
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Erk-RIGHT__Erk-_r183
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r183 1383
participant stoichiometry: PARTICIPANT STOICHIOMETRY r183 1384
left: Erk
interaction type: STATE_TRANSITION
right: Erk

uniprot F6TAH0 1277
type: UnificationXref
id: F6TAH0
db: uniprot

uniprot Q6Q7I7 696
type: UnificationXref
id: Q6Q7I7
db: uniprot

GRB2
type: Protein
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot O43639 513
type: UnificationXref
id: O43639
db: uniprot

uniprot Q6DV79 533
type: UnificationXref
id: Q6DV79
db: uniprot

uniprot E2R428 560
type: UnificationXref
id: E2R428
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF87
xref: uniprot B1WBR9 326
organism: Rattus norvegicus

Src
type: Protein
entity reference: Src
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot O94806 589
type: UnificationXref
id: O94806
db: uniprot

uniprot Q8N474 980
type: UnificationXref
id: Q8N474
db: uniprot

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot Q62829 1174
organism: Rattus norvegicus

uniprot P23927 824
type: UnificationXref
id: P23927
db: uniprot

uniprot Q8UUX0 675
type: UnificationXref
id: Q8UUX0
db: uniprot

uniprot F6XGB0 341
type: UnificationXref
id: F6XGB0
db: uniprot

uniprot F7DIA9 123
type: UnificationXref
id: F7DIA9
db: uniprot

uniprot F6RPG1 121
type: UnificationXref
id: F6RPG1
db: uniprot

uniprot G3X7B5 665
type: UnificationXref
id: G3X7B5
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF77
xref: uniprot Q9U6V0 392
organism: Ciona intestinalis

uniprot F7FDA0 918
type: UnificationXref
id: F7FDA0
db: uniprot

uniprot O95996 214
type: UnificationXref
id: O95996
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__STAT1-RIGHT__STAT1-_r178
controller: JAK1

uniprot P16092 70
type: UnificationXref
id: P16092
db: uniprot

STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re105
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re105 1480
participant stoichiometry: PARTICIPANT STOICHIOMETRY re105 1479
left: BAD
interaction type: STATE_TRANSITION
right: BAD

uniprot F6S3S1 434
type: UnificationXref
id: F6S3S1
db: uniprot

STATE_TRANSITION_LEFT__BAD-RIGHT__BAD-_re107
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re107 1471
participant stoichiometry: PARTICIPANT STOICHIOMETRY re107 1472
left: BAD
interaction type: STATE_TRANSITION
right: BAD

uniprot Q9Z280 314
type: UnificationXref
id: Q9Z280
db: uniprot

Ca2+
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=ION

uniprot F7HDY6 469
type: UnificationXref
id: F7HDY6
db: uniprot

uniprot H2PZQ7 1005
type: UnificationXref
id: H2PZQ7
db: uniprot

VEGFR-2
type: Protein
entity reference: VEGFR-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa24 1319
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9I946 702
type: UnificationXref
id: Q9I946
db: uniprot

uniprot Q22227 266
type: UnificationXref
id: Q22227
db: uniprot

EphR
type: Protein
entity reference: EphR
feature: COMPLEX PARTICIPANT BINDING FEATURE s227 sa5 1331
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A5A6H0 868
type: UnificationXref
id: A5A6H0
db: uniprot

PARTICIPANT STOICHIOMETRY r146 1516
type: Stoichiometry
physical entity: CSL
stoichiometric coefficient: 1.0

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot E2RGU7 561
organism: Canis lupus familiaris

Crk-like protein
type: ProteinReference
xref: uniprot Q5U2U2 407
xref: PTHR19969:SF20
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r146 1515
type: Stoichiometry
physical entity: CSL
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UM70 464
organism: Monodelphis domestica

Ca2 PLUS s209 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MEKK1-RIGHT__MEKK1-_r244
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r244 1511
participant stoichiometry: PARTICIPANT STOICHIOMETRY r244 1512
left: MEKK1
interaction type: STATE_TRANSITION
right: MEKK1

eco ECO:0000316 151
type: UnificationXref
id: ECO:0000316
db: eco

uniprot F6SXE2 485
type: UnificationXref
id: F6SXE2
db: uniprot

uniprot H2QI72 11
type: UnificationXref
id: H2QI72
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 646
xref: PTHR24055:SF222
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7G3I5 919
xref: PTHR10048:SF107
organism: Monodelphis domestica

Transforming growth factor beta 1 induced transcript 1
type: ProteinReference
xref: uniprot A0A2I3SRD0 188
organism: Pan troglodytes

SHC (Src homology 2 domain containing) transforming protein 1
type: ProteinReference
xref: uniprot H2R8L2 41
xref: PTHR10337:SF2
organism: Pan troglodytes

GTPase
type: ProteinReference
xref: P00254
standard name: Rho guanosine triphosphatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.GTPase
comment: ENTITY_REFERENCE_NOTES=Long Name: Rho guanosine triphosphatase Synonym: RAS Homolog Gene Family,Rho,Rho GTPase Accession: P00254
member entity reference: Ras homolog family member A
member entity reference: Rho-related GTP-binding protein RhoC
member entity reference: RIKEN cDNA 4930544G11
member entity reference: Uncharacterized protein
member entity reference: GTP-binding protein rho1
member entity reference: Rho-related GTP-binding protein RhoB
member entity reference: Novel Rho protein
member entity reference: GTP-binding protein rhoA
member entity reference: Rho-related GTP-binding protein RhoA-A
member entity reference: GTP-binding protein rho5
member entity reference: Rho-related GTP-binding protein RhoA-B
member entity reference: RSA-14-44 protein
member entity reference: Transforming protein RhoA
member entity reference: Protein CBR-RHO-1
member entity reference: Ras-like GTP-binding protein rhoA
member entity reference: Ras homolog family member B
member entity reference: Predicted protein
member entity reference: GTP-binding protein RHO1
member entity reference: GTP-binding protein
member entity reference: Rho-related GTP-binding protein RhoA-D
member entity reference: YALI0D01045p
member entity reference: YALI0E23001p
member entity reference: RhoA protein
member entity reference: RHOA isoform 2
member entity reference: Ras-like GTP-binding protein Rho1
member entity reference: Ras homolog family member C

uniprot A0A2I3SDP5 187
type: UnificationXref
id: A0A2I3SDP5
db: uniprot

PARTICIPANT STOICHIOMETRY r147 1514
type: Stoichiometry
physical entity: PAR
stoichiometric coefficient: 1.0

Docking protein 2
type: ProteinReference
xref: uniprot F7EZV2 10
organism: Macaca mulatta

uniprot A0A3Q1MMD9 1273
type: UnificationXref
id: A0A3Q1MMD9
db: uniprot

PARTICIPANT STOICHIOMETRY r147 1513
type: Stoichiometry
physical entity: PAR
stoichiometric coefficient: 1.0

GO GO:0005783 2
type: UnificationXref
id: GO:0005783
db: GO

Frizzled-2
type: ProteinReference
xref: PTHR11309:SF34
xref: uniprot Q9JIP6 139
organism: Mus musculus

uniprot Q6PC73 865
type: UnificationXref
id: Q6PC73
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNKK1-RIGHT__JNKK1-_r152
controller: MEKK1

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot A0A3Q1M353 1073
organism: Bos taurus

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot F6SM70 67
xref: PTHR24416:SF131
organism: Ornithorhynchus anatinus

Protein CBR-LET-60
type: ProteinReference
xref: uniprot A8X0X5 990
organism: Caenorhabditis briggsae

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot E2R428 560
organism: Canis lupus familiaris

Survivin
type: ProteinReference
xref: P00198
standard name: Baculoviral IAP Repeat-Containing Protein 5
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Survivin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Baculoviral IAP Repeat-Containing Protein 5 Synonym: API4,Apoptosis inhibitor 4,BIRC5 Accession: P00198
member entity reference: Baculoviral IAP repeat-containing protein 5.1
member entity reference: Uncharacterized protein
member entity reference: Baculoviral IAP repeat-containing protein 5

uniprot Q9QYE5 762
type: UnificationXref
id: Q9QYE5
db: uniprot

MEK
type: ProteinReference
xref: P00225
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.MEK
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen Activated Protein Kinase Kinase Synonym: MAP kinase kinase,MAP/ERK Kinase,MAP2K,MAPKK,MKK,PRKMK,Protein Kinase, Mitogen-Activated, Kinase Accession: P00225
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Mitogen-activated protein kinase
member entity reference: Uncharacterized protein

uniprot A8WV10 325
type: UnificationXref
id: A8WV10
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F6SLU9 339
xref: PTHR12027:SF91
organism: Macaca mulatta

RHOA isoform 2
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot H2QML4 1216
organism: Pan troglodytes

uniprot O60496 14
type: UnificationXref
id: O60496
db: uniprot

uniprot E1BMG4 556
type: UnificationXref
id: E1BMG4
db: uniprot

Transforming growth factor beta-1-induced transcript 1 protein
type: ProteinReference
xref: uniprot Q3MHZ4 199
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r223 1352
type: Stoichiometry
physical entity: FRS-2
stoichiometric coefficient: 1.0

Focal adhesion kinase 1
type: ProteinReference
xref: uniprot Q00944 429
xref: PTHR24418:SF78
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r223 1351
type: Stoichiometry
physical entity: FRS-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r286 1358
type: Stoichiometry
physical entity: VRAP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r286 1357
type: Stoichiometry
physical entity: VRAP
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot P47811 33
organism: Mus musculus

uniprot Q8IS21 183
type: UnificationXref
id: Q8IS21
db: uniprot

Dishevelled segment polarity protein 3a
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot B8JMI2 248
organism: Danio rerio

RhoA protein
type: ProteinReference
xref: uniprot A7EEX6 1205
organism: Sclerotinia sclerotiorum

uniprot F7CW18 426
type: UnificationXref
id: F7CW18
db: uniprot

PTHR18896:SF121
type: RelationshipXref
id: PTHR18896:SF121
db: PANTHER Family
relationship type: By Homology

Axin
type: Protein
entity reference: Axin
feature: ACTIVE 25
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa9 1335
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P21708 291
xref: PTHR24055:SF393
organism: Rattus norvegicus

uniprot F1ML02 461
type: UnificationXref
id: F1ML02
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot P47809 245
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot Q13233 418
organism: Homo sapiens

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
type: ProteinReference
xref: uniprot O00750 932
xref: PTHR10048:SF30
organism: Homo sapiens

uniprot H2QKD0 1279
type: UnificationXref
id: H2QKD0
db: uniprot

uniprot Q9JIA7 802
type: UnificationXref
id: Q9JIA7
db: uniprot

uniprot P43446 373
type: UnificationXref
id: P43446
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 38

uniprot P29474 436
type: UnificationXref
id: P29474
db: uniprot

uniprot F6ZIJ4 973
type: UnificationXref
id: F6ZIJ4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PAR-RIGHT__PAR-_r147
controller: FVIIa

Nitric oxide synthase, endothelial
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot Q9TUX8 439
organism: Canis lupus familiaris

Protein tyrosine kinase 2
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot E2RGQ1 424
organism: Canis lupus familiaris

SH2 domain containing 2A
type: ProteinReference
evidence: Evidence 222
xref: uniprot H2R8K0 223
xref: PTHR14388:SF9
organism: Pan troglodytes

STATE_TRANSITION_LEFT__STAT3-RIGHT__STAT3-_r177
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r177 1411
participant stoichiometry: PARTICIPANT STOICHIOMETRY r177 1410
left: STAT3
interaction type: STATE_TRANSITION
right: STAT3

uniprot Q9JHK1 523
type: UnificationXref
id: Q9JHK1
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF87
xref: uniprot F7DI28 344
organism: Xenopus tropicalis

Protein kinase C, eye isozyme
type: ProteinReference
xref: uniprot P13677 598
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__Crk-RIGHT__Crk-_r221
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r221 1359
participant stoichiometry: PARTICIPANT STOICHIOMETRY r221 1360
left: Crk
interaction type: STATE_TRANSITION
right: Crk

HETERODIMER_ASSOCIATION_LEFT__GSK3beta-_APC-_Axin-RIGHT__Complex__Axin_APC__GSK3beta_-_r190
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r190 1555
participant stoichiometry: PARTICIPANT STOICHIOMETRY r190 1556
participant stoichiometry: PARTICIPANT STOICHIOMETRY r190 1557
participant stoichiometry: PARTICIPANT STOICHIOMETRY r190 1554
left: Axin
left: APC
left: GSK3beta
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Axin/APC/ GSK3beta)

Protein Wnt-10b
type: ProteinReference
xref: PTHR12027:SF76
xref: uniprot O00744 355
organism: Homo sapiens

PTHR24044:SF380
type: RelationshipXref
id: PTHR24044:SF380
db: PANTHER Family
relationship type: By Homology

Notch 4
type: ProteinReference
xref: uniprot H2RDK4 1260
xref: PTHR24044:SF450
organism: Pan troglodytes

Complex (FGFR-1/FGF)
type: Complex
component stoichiometry: FGF s31 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: FGFR 1 s30 sa12 STOICHIOMETRY ID COMPLEX
component: FGFR-1
component: FGF
feature: COMPLEX BINDING FEATURE s172 a206 1306
feature: COMPLEX BINDING FEATURE s172 a206 1304
cellular location: plasma membrane

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot D4A5Q1 893
organism: Rattus norvegicus

Coagulation factor VII
type: ProteinReference
xref: PTHR24278:SF26
xref: uniprot P08709 275
organism: Homo sapiens

Cytoplasmic protein
type: ProteinReference
xref: uniprot F1P4Q4 507
xref: PTHR19969:SF12
organism: Gallus gallus

Adapter molecule Crk
type: ProteinReference
xref: uniprot Q9XYM0 413
organism: Drosophila melanogaster

uniprot D3ZH39 460
type: UnificationXref
id: D3ZH39
db: uniprot

PTHR24072:SF0
type: RelationshipXref
id: PTHR24072:SF0
db: PANTHER Family
relationship type: By Homology

FRS-2
type: ProteinReference
xref: P00240
standard name: Fibroblast Growth Factor Receptor Substrate 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Fibroblast Growth Factor Receptor Substrate 2 Synonym: FRS2-Alpha,FRS2A,SNT,SNT1,SUC1-Associated Neurotrophic Factor Target 1 Accession: P00240
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.FRS-2
member entity reference: Uncharacterized protein
member entity reference: FRS3 protein
member entity reference: Fibroblast growth factor receptor substrate 2
member entity reference: FRS3 isoform 1
member entity reference: Fibroblast growth factor receptor substrate 3

Rho GTPase-activating protein 8
type: ProteinReference
xref: uniprot P85298 1117
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r246 1507
type: Stoichiometry
physical entity: JNK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r246 1508
type: Stoichiometry
physical entity: JNK1
stoichiometric coefficient: 1.0

Proline-rich protein 5
type: ProteinReference
xref: uniprot P85299 1118
organism: Homo sapiens

GTP-binding protein rho1
type: ProteinReference
xref: uniprot Q09914 1230
organism: Schizosaccharomyces pombe

uniprot Q9U2Q9 452
type: UnificationXref
id: Q9U2Q9
db: uniprot

Protein enhancer of sevenless 2B
type: ProteinReference
xref: uniprot Q08012 860
organism: Drosophila melanogaster

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot P15056 1086
organism: Homo sapiens

c-Jun
type: Protein
entity reference: c-Jun
feature: ACTIVE 25
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase D2
type: ProteinReference
xref: PTHR22968:SF12
xref: uniprot Q8BZ03 627
organism: Mus musculus

Fzd
type: Protein
entity reference: Fzd
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa8 1311
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SHC-RIGHT__SHC-_r222
controller: Complex (PDGFR/PDGF)

uniprot F7G3I5 919
type: UnificationXref
id: F7G3I5
db: uniprot

uniprot F1MIA2 566
type: UnificationXref
id: F1MIA2
db: uniprot

uniprot A0A1D5QFE1 318
type: UnificationXref
id: A0A1D5QFE1
db: uniprot

PTHR11309:SF81
type: RelationshipXref
id: PTHR11309:SF81
db: PANTHER Family
relationship type: By Homology

uniprot F7GDI5 734
type: UnificationXref
id: F7GDI5
db: uniprot

PTHR11309:SF87
type: RelationshipXref
id: PTHR11309:SF87
db: PANTHER Family
relationship type: By Homology

uniprot Q91WJ0 1058
type: UnificationXref
id: Q91WJ0
db: uniprot

Neurogenic locus Notch protein
type: ProteinReference
xref: uniprot P07207 1262
organism: Drosophila melanogaster

TEK isoform 2
type: ProteinReference
xref: uniprot A0A2I3RZH3 1143
xref: PTHR24416:SF125
organism: Pan troglodytes

Ras-like protein rasG
type: ProteinReference
xref: uniprot P15064 1013
organism: Dictyostelium discoideum

Segment polarity protein dishevelled homolog DVL-3
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot Q92997 270
organism: Homo sapiens

Stress-activated protein kinase JNK
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot P92208 649
organism: Drosophila melanogaster

uniprot Q05655 616
type: UnificationXref
id: Q05655
db: uniprot

Catenin beta-1
type: ProteinReference
xref: uniprot P35222 92
xref: PTHR45976:SF4
organism: Homo sapiens

uniprot Q9QUI0 1253
type: UnificationXref
id: Q9QUI0
db: uniprot

PARTICIPANT STOICHIOMETRY r176 1415
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

uniprot F1NN48 232
type: UnificationXref
id: F1NN48
db: uniprot

PARTICIPANT STOICHIOMETRY r176 1414
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

PTHR11309:SF97
type: RelationshipXref
id: PTHR11309:SF97
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF99
type: RelationshipXref
id: PTHR11309:SF99
db: PANTHER Family
relationship type: By Homology

uniprot H2QMY7 470
type: UnificationXref
id: H2QMY7
db: uniprot

uniprot Q9CX99 867
type: UnificationXref
id: Q9CX99
db: uniprot

uniprot H2QR74 146
type: UnificationXref
id: H2QR74
db: uniprot

Protein CBR-SEM-5
type: ProteinReference
xref: uniprot A8XPY6 857
organism: Caenorhabditis briggsae

uniprot H2QNU7 259
type: UnificationXref
id: H2QNU7
db: uniprot

Serine/threonine-protein kinase D2
type: ProteinReference
xref: uniprot Q5XIS9 621
xref: PTHR22968:SF12
organism: Rattus norvegicus

ARHGAP1 isoform 3
type: ProteinReference
xref: PTHR45808:SF6
xref: uniprot H2Q3I0 1115
organism: Pan troglodytes

Protein Wnt
type: ProteinReference
xref: uniprot E2RH98 334
xref: PTHR12027:SF89
organism: Canis lupus familiaris

uniprot A0A3Q1LSY0 1151
type: UnificationXref
id: A0A3Q1LSY0
db: uniprot

Fzd s25 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fzd
stoichiometric coefficient: 1.0

uniprot F6RKF7 120
type: UnificationXref
id: F6RKF7
db: uniprot

uniprot F1N7N8 143
type: UnificationXref
id: F1N7N8
db: uniprot

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r180 1389
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot F7HLC7 921
organism: Macaca mulatta

uniprot Q5U2U2 407
type: UnificationXref
id: Q5U2U2
db: uniprot

uniprot P34885 606
type: UnificationXref
id: P34885
db: uniprot

uniprot Q9R1A7 162
type: UnificationXref
id: Q9R1A7
db: uniprot

PARTICIPANT STOICHIOMETRY r207 1425
type: Stoichiometry
physical entity: PLA2
stoichiometric coefficient: 1.0

Protein tyrosine kinase 2
type: ProteinReference
xref: PTHR24418:SF78
xref: uniprot A0A2I3T3L8 420
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r207 1426
type: Stoichiometry
physical entity: PLA2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r288 1350
type: Stoichiometry
physical entity: Src
stoichiometric coefficient: 1.0

uniprot F6RYL1 540
type: UnificationXref
id: F6RYL1
db: uniprot

Caspase-9
type: ProteinReference
xref: uniprot Q8C3Q9 522
xref: PTHR10454:SF157
organism: Mus musculus

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot O57328 128
organism: Gallus gallus

uniprot A0A2I3TQ88 524
type: UnificationXref
id: A0A2I3TQ88
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot E2RH85 896
organism: Canis lupus familiaris

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3RQJ8 548
xref: PTHR24356:SF214
organism: Pan troglodytes

uniprot Q6PF93 957
type: UnificationXref
id: Q6PF93
db: uniprot

uniprot A0A3Q1ME99 785
type: UnificationXref
id: A0A3Q1ME99
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A3Q1LQK4 887
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r180 1390
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot P47713 775
type: UnificationXref
id: P47713
db: uniprot

uniprot F7D094 509
type: UnificationXref
id: F7D094
db: uniprot

GSK3beta
type: ProteinReference
xref: P00211
standard name: Glycogen synthase kinase 3-beta
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.GSK3_beta_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Glycogen Synthase Kinase 3-beta Synonym: GSK3-beta Accession: P00211
member entity reference: Uncharacterized protein
member entity reference: Si:dkeyp-80c12.7
member entity reference: Glycogen synthase kinase-3
member entity reference: Glycogen synthase kinase-3 beta
member entity reference: Glycogen synthase kinase 3 beta
member entity reference: Glycogen synthase kinase
member entity reference: Putative glycogen synthase kinase-3 homolog
member entity reference: Glycogen synthase kinase-3 beta isoform 1
member entity reference: Glycogen synthase kinase 3

uniprot O77438 130
type: UnificationXref
id: O77438
db: uniprot

Angiopoietin-2
type: ProteinReference
xref: PTHR19143:SF199
xref: uniprot O15123 1132
organism: Homo sapiens

c-Fos
type: Protein
entity reference: c-Fos
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Ang_1-RIGHT__Ang_1-_re113
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 1457
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 1456
left: Ang-1
interaction type: STATE_TRANSITION
right: Ang-1

uniprot Q13467 134
type: UnificationXref
id: Q13467
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 995

uniprot P28466 370
type: UnificationXref
id: P28466
db: uniprot

PTHR24044:SF320
type: RelationshipXref
id: PTHR24044:SF320
db: PANTHER Family
relationship type: By Homology

uniprot P42533 154
type: UnificationXref
id: P42533
db: uniprot

PARTICIPANT STOICHIOMETRY r280 1378
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r280 1379
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

Paxillin
type: Protein
entity reference: Paxillin
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

SPK
type: ProteinReference
xref: P00229
standard name: Sphingosine Kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.SPK
comment: ENTITY_REFERENCE_NOTES=Long Name: Sphingosine Kinase Synonym: SPHK Accession: P00229
member entity reference: RCG53912, isoform CRA_a
member entity reference: Sphingosine kinase 2
member entity reference: Sphingosine kinase 1
member entity reference: Sphingosine kinase 2 isoform a

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q503B6 1021
organism: Danio rerio

JNK1
type: Protein
entity reference: JNK1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P17325 544
organism: Rattus norvegicus

SHC
type: Protein
entity reference: SHC
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1LUE0 65
type: UnificationXref
id: A0A3Q1LUE0
db: uniprot

uniprot F1QNG4 1001
type: UnificationXref
id: F1QNG4
db: uniprot

Growth factor receptor-bound protein 14
type: ProteinReference
xref: uniprot F1MBA2 227
xref: PTHR11243:SF22
organism: Bos taurus

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot Q0V7L8 749
organism: Bos taurus

uniprot P14056 1085
type: UnificationXref
id: P14056
db: uniprot

uniprot Q28H51 235
type: UnificationXref
id: Q28H51
db: uniprot

uniprot P49147 776
type: UnificationXref
id: P49147
db: uniprot

PTHR10048:SF29
type: RelationshipXref
id: PTHR10048:SF29
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF28
type: RelationshipXref
id: PTHR10048:SF28
db: PANTHER Family
relationship type: By Homology

uniprot Q2F9P2 278
type: UnificationXref
id: Q2F9P2
db: uniprot

uniprot H9FVU5 928
type: UnificationXref
id: H9FVU5
db: uniprot

uniprot F6VW12 1146
type: UnificationXref
id: F6VW12
db: uniprot

PTHR24216:SF11
type: RelationshipXref
id: PTHR24216:SF11
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF30
type: RelationshipXref
id: PTHR10048:SF30
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot A0A1D5R8E9 1271
organism: Macaca mulatta

Protein delta homolog 1
type: ProteinReference
xref: uniprot Q09163 748
organism: Mus musculus

uniprot H2QJF8 350
type: UnificationXref
id: H2QJF8
db: uniprot

uniprot E2R186 66
type: UnificationXref
id: E2R186
db: uniprot

uniprot A5A6H2 869
type: UnificationXref
id: A5A6H2
db: uniprot

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: uniprot O14640 260
xref: PTHR10878:SF5
organism: Homo sapiens

Segment polarity protein dishevelled homolog DVL-2
type: ProteinReference
xref: uniprot O14641 261
xref: PTHR10878:SF8
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r293 1547
type: Stoichiometry
physical entity: MAPKAPK2/3
stoichiometric coefficient: 1.0

uniprot F1MGM1 115
type: UnificationXref
id: F1MGM1
db: uniprot

uniprot A0A2I3RMA9 64
type: UnificationXref
id: A0A2I3RMA9
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot P23726 939
organism: Bos taurus

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P23727 940
organism: Bos taurus

PAR
type: ProteinReference
xref: P00192
standard name: Protease Activated Receptor
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.RECEPTOR.PAR
comment: ENTITY_REFERENCE_NOTES=Long Name: Protease Activated Receptor Synonym: NR1I2,Nuclear Receptor Subfamily 1, Group I, Member 2,PXR,Pregnane X Receptor,SXR,Steroid and Xenobiotic Receptor Accession: P00192
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Nuclear receptor subfamily 1 group I member 2
member entity reference: Proteinase-activated receptor 1
member entity reference: NR1I2 isoform 4

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q63932 712
organism: Mus musculus

Cytosolic phospholipase A2 gamma
type: ProteinReference
xref: uniprot Q9UP65 1188
organism: Homo sapiens

uniprot P02470 817
type: UnificationXref
id: P02470
db: uniprot

PARTICIPANT STOICHIOMETRY re115 1451
type: Stoichiometry
physical entity: Complex (Tie2/Ang-1)
stoichiometric coefficient: 1.0

GO GO:0005886 4
type: UnificationXref
id: GO:0005886
db: GO

PTHR11309:SF11
type: RelationshipXref
id: PTHR11309:SF11
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r293 1546
type: Stoichiometry
physical entity: MAPKAPK2/3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re115 1450
type: Stoichiometry
physical entity: Complex (Tie2/Ang-1)
stoichiometric coefficient: 1.0

Recombination signal binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: uniprot F6ULE6 844
xref: PTHR10665:SF3
organism: Ornithorhynchus anatinus

uniprot F6SZ66 906
type: UnificationXref
id: F6SZ66
db: uniprot

uniprot E2QSB5 1029
type: UnificationXref
id: E2QSB5
db: uniprot

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot A0A3Q1LJJ3 101
organism: Bos taurus

uniprot P49024 197
type: UnificationXref
id: P49024
db: uniprot

Protein jagged-2
type: ProteinReference
xref: uniprot Q9Y219 764
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6RCU6 662
xref: PTHR24356:SF171
organism: Macaca mulatta

PI3K
type: Protein
entity reference: PI3K
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P29319 474
type: UnificationXref
id: P29319
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GRB2-RIGHT__GRB2-_r225
controller: SHC

cPLA2
type: ProteinReference
xref: P00251
standard name: Cytosolic Phospholipase A2
comment: ENTITY_REFERENCE_NOTES=Long Name: Cytosolic Phospholipase A2 Synonym: PLA2 Accession: P00251
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.cPLA_sub_2_endsub
member entity reference: Cytosolic phospholipase A2
member entity reference: Cytosolic phospholipase A2 gamma
member entity reference: Cytosolic phospholipase A2 delta
member entity reference: Phospholipase A2
member entity reference: PLA2G4C isoform 4
member entity reference: Zgc:101699
member entity reference: Cytosolic phospholipase A2 beta

uniprot H2QDQ1 584
type: UnificationXref
id: H2QDQ1
db: uniprot

uniprot Q552M5 181
type: UnificationXref
id: Q552M5
db: uniprot

uniprot A8X7Y4 190
type: UnificationXref
id: A8X7Y4
db: uniprot

uniprot P10398 1082
type: UnificationXref
id: P10398
db: uniprot

uniprot P32254 1017
type: UnificationXref
id: P32254
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot G3V9W2 79
organism: Rattus norvegicus

ETS proto-oncogene 1, transcription factor
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot A0A2I3TF56 100
organism: Pan troglodytes

Raf
type: Protein
entity reference: Raf
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot F6WX28 871
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r157
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r157 1484
participant stoichiometry: PARTICIPANT STOICHIOMETRY r157 1483
left: Akt
interaction type: STATE_TRANSITION
right: Akt

uniprot F6TD14 907
type: UnificationXref
id: F6TD14
db: uniprot

GTPase
type: Protein
entity reference: GTPase
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1LTT9 26
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

Phosphatidylinositol 3-kinase age-1
type: ProteinReference
xref: uniprot Q94125 965
organism: Caenorhabditis elegans

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 1240

Protein kinase C zeta type
type: ProteinReference
xref: uniprot Q02956 613
xref: PTHR24356:SF170
organism: Mus musculus

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot A0A3Q1N9F5 551
xref: PTHR22968:SF9
organism: Bos taurus

uniprot A0A3Q2TVV5 441
type: UnificationXref
id: A0A3Q2TVV5
db: uniprot

PTHR11309:SF34
type: RelationshipXref
id: PTHR11309:SF34
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r176
controller: Erk

Frizzled-1
type: ProteinReference
xref: PTHR11309:SF81
xref: uniprot Q9UP38 141
organism: Homo sapiens

uniprot Q99704 23
type: UnificationXref
id: Q99704
db: uniprot

ncbitaxon 227321 1247
type: UnificationXref
id: 227321
db: ncbitaxon

Nuclear receptor subfamily 1 group I member 2
type: ProteinReference
xref: uniprot O54915 157
organism: Mus musculus

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P63318 608
xref: PTHR24356:SF162
organism: Mus musculus

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P63319 609
xref: PTHR24356:SF162
organism: Rattus norvegicus

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot P49841 448
organism: Homo sapiens

uniprot Q04929 406
type: UnificationXref
id: Q04929
db: uniprot

PTHR24361:SF414
type: RelationshipXref
id: PTHR24361:SF414
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r157 1484
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

Focal adhesion kinase 1
type: ProteinReference
xref: uniprot Q05397 430
xref: PTHR24418:SF78
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r157 1483
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

PTHR11309:SF22
type: RelationshipXref
id: PTHR11309:SF22
db: PANTHER Family
relationship type: By Homology

uniprot E1BIM8 48
type: UnificationXref
id: E1BIM8
db: uniprot

PARTICIPANT STOICHIOMETRY r222 1356
type: Stoichiometry
physical entity: SHC
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK1-RIGHT__MEKK1-_r151
controller: PAR

PARTICIPANT STOICHIOMETRY r222 1355
type: Stoichiometry
physical entity: SHC
stoichiometric coefficient: 1.0

Ca2 PLUS s53 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__p38MAPK-RIGHT__p38MAPK-_r294
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r294 1544
participant stoichiometry: PARTICIPANT STOICHIOMETRY r294 1545
left: p38MAPK
interaction type: STATE_TRANSITION
right: p38MAPK

uniprot P03968 488
type: UnificationXref
id: P03968
db: uniprot

uniprot Q99PR8 835
type: UnificationXref
id: Q99PR8
db: uniprot

PARTICIPANT STOICHIOMETRY r205 1432
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

ncbitaxon 9544 6
type: UnificationXref
id: 9544
db: ncbitaxon

Serine/threonine-protein kinase pak-1
type: ProteinReference
xref: uniprot Q17850 1172
organism: Caenorhabditis elegans

DiSHevelled related
type: ProteinReference
xref: uniprot Q18239 264
organism: Caenorhabditis elegans

uniprot P20444 601
type: UnificationXref
id: P20444
db: uniprot

uniprot Q02763 1148
type: UnificationXref
id: Q02763
db: uniprot

uniprot J9P5H0 353
type: UnificationXref
id: J9P5H0
db: uniprot

uniprot H2R1H5 1193
type: UnificationXref
id: H2R1H5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r157
controller: GTPase

STATE_TRANSITION_LEFT__STAT1-RIGHT__STAT1-_r253
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r253 1477
participant stoichiometry: PARTICIPANT STOICHIOMETRY r253 1478
left: STAT1
interaction type: STATE_TRANSITION
right: STAT1

DLK1 isoform 1
type: ProteinReference
xref: uniprot H2RDH4 736
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r205 1431
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot A0A3Q1MBG6 798
type: UnificationXref
id: A0A3Q1MBG6
db: uniprot

STATE_TRANSITION_LEFT__CSL-RIGHT__CSL-_r146
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r146 1516
participant stoichiometry: PARTICIPANT STOICHIOMETRY r146 1515
left: CSL
interaction type: STATE_TRANSITION
right: CSL

uniprot H2QLQ2 690
type: UnificationXref
id: H2QLQ2
db: uniprot

AGAP011036-PA (Fragment)
type: ProteinReference
xref: uniprot A0NBA9 889
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: PTHR11633:SF4
xref: uniprot F7GEA7 688
organism: Macaca mulatta

uniprot F6W5V4 1113
type: UnificationXref
id: F6W5V4
db: uniprot

Ephrin B1
type: ProteinReference
xref: uniprot E2QSB5 1029
organism: Canis lupus familiaris

Protein Wnt-10a
type: ProteinReference
xref: uniprot P43446 373
xref: PTHR12027:SF89
organism: Danio rerio

Nck
type: ProteinReference
xref: P00215
standard name: Nck Adaptor Protein
comment: ENTITY_REFERENCE_NOTES=Long Name: Nck Adaptor Protein Synonym: Synonym not specified Accession: P00215
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Nck
member entity reference: Cytoplasmic protein
member entity reference: Cytoplasmic protein NCK2
member entity reference: Cytoplasmic protein NCK1

uniprot A0A2I3TSS9 189
type: UnificationXref
id: A0A2I3TSS9
db: uniprot

Delta/Serrate
type: ProteinReference
xref: P00226
standard name: Delta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Delta/Serrate
comment: ENTITY_REFERENCE_NOTES=Long Name: Delta Synonym: Dll,JAG,JAGL,Jagged,Ser,Serrate Accession: P00226
member entity reference: Protein delta homolog 1
member entity reference: Delta-like protein
member entity reference: DLK1 isoform 1
member entity reference: DLL3 isoform 4
member entity reference: Delta-like protein 1
member entity reference: Protein jagged-1
member entity reference: Delta-like protein 3
member entity reference: Delta-like protein 4
member entity reference: Uncharacterized protein
member entity reference: AGAP010940-PA (Fragment)
member entity reference: Delta-like protein C
member entity reference: Neurogenic locus protein delta
member entity reference: Protein serrate
member entity reference: Protein jagged-2
member entity reference: Delta-like protein D
member entity reference: C901
member entity reference: Delta-like protein B
member entity reference: Protein jagged-1b
member entity reference: Protein jagged-1a
member entity reference: Delta-like protein A

uniprot Q04970 1019
type: UnificationXref
id: Q04970
db: uniprot

MEK
type: Protein
entity reference: MEK
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

VEGFR-2
type: ProteinReference
xref: P00222
standard name: Vascular Endothelial Growth Factor Receptor-2
comment: ENTITY_REFERENCE_NOTES=Long Name: Vascular Endothelial Growth Factor Receptor-2 Synonym: FLK1,KDR,Kinase Insert Domain Receptor,Tyrosine Kinase Growth Factor Receptor Accession: P00222
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.RECEPTOR.VEGFR-2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Vascular endothelial growth factor receptor 2
member entity reference: Uncharacterized protein
member entity reference: Kinase insert domain receptor
member entity reference: KDR isoform 1
member entity reference: Vascular endothelial growth factor receptor kdr-like

uniprot P08709 275
type: UnificationXref
id: P08709
db: uniprot

RBPJ isoform 12
type: ProteinReference
xref: uniprot A0A2J8NVW7 839
xref: PTHR10665:SF3
organism: Pan troglodytes

uniprot A0JND0 497
type: UnificationXref
id: A0JND0
db: uniprot

uniprot Q63844 296
type: UnificationXref
id: Q63844
db: uniprot

uniprot P36506 707
type: UnificationXref
id: P36506
db: uniprot

uniprot F1A411 999
type: UnificationXref
id: F1A411
db: uniprot

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: PTHR24349:SF64
xref: uniprot F7BFL2 1095
organism: Macaca mulatta

Adenomatous polyposis coli 2
type: ProteinReference
xref: uniprot Q9Y1T2 219
organism: Drosophila melanogaster

Protein delta homolog 1
type: ProteinReference
xref: uniprot O70534 740
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r140
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r140 1520
participant stoichiometry: PARTICIPANT STOICHIOMETRY r140 1521
left: Akt
interaction type: STATE_TRANSITION
right: Akt

uniprot P21552 363
type: UnificationXref
id: P21552
db: uniprot

uniprot P70701 376
type: UnificationXref
id: P70701
db: uniprot

Eph
type: ProteinReference
xref: P00239
standard name: Ephrin
comment: ENTITY_REFERENCE_NOTES=Long Name: Ephrin Synonym: EFL,EFN,EPH-Related Receptor Tyrosine Kinase Ligand,EPLG,LERK,Ligand of EPH-Related Kinase Accession: P00239
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Eph
member entity reference: Ephrin B2
member entity reference: Ephrin-B1
member entity reference: EFNB2 isoform 1
member entity reference: Ephrin-B2a
member entity reference: Ephrin-B2
member entity reference: EPH-related receptor tyrosine kinase ligand 2
member entity reference: Ephrin B1
member entity reference: Ephrin-B2b
member entity reference: Uncharacterized protein

uniprot A6H6X8 324
type: UnificationXref
id: A6H6X8
db: uniprot

GAP
type: ProteinReference
xref: P00205
standard name: GTPase-Activating Protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.GAP
comment: ENTITY_REFERENCE_NOTES=Long Name: GTPase-Activating Protein Synonym: Guanosine Triphosphatase-Activating Protein,RAS p21 Protein Activator 1,RASA1,RASGAP Accession: P00205
member entity reference: RAS p21 protein activator 1
member entity reference: Ras GTPase-activating protein 1
member entity reference: RAS p21 protein activator (GTPase activating protein) 1
member entity reference: Uncharacterized protein

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 2

uniprot P17325 544
type: UnificationXref
id: P17325
db: uniprot

Sck
type: Protein
entity reference: Sck
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Complex (PDGFR/PDGF)
type: Complex
component stoichiometry: PDGFR s33 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: PDGF s34 sa15 STOICHIOMETRY ID COMPLEX
component: PDGFR
component: PDGF
feature: COMPLEX BINDING FEATURE s181 a235 1290
feature: COMPLEX BINDING FEATURE s181 a235 1288
cellular location: plasma membrane

uniprot A0A0G2JY48 456
type: UnificationXref
id: A0A0G2JY48
db: uniprot

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot Q9Y243 678
organism: Homo sapiens

uniprot Q9NRA0 803
type: UnificationXref
id: Q9NRA0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QYV3 811
organism: Monodelphis domestica

HSPB2 isoform 1
type: ProteinReference
xref: uniprot K7BZ54 815
organism: Pan troglodytes

uniprot F6SGW3 972
type: UnificationXref
id: F6SGW3
db: uniprot

uniprot F1QFP3 274
type: UnificationXref
id: F1QFP3
db: uniprot

GRB2-related adapter protein
type: ProteinReference
xref: uniprot Q9CX99 867
organism: Mus musculus

PIK3R1 isoform 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot A0A2I3SIY1 883
organism: Pan troglodytes

uniprot Q95ME4 1025
type: UnificationXref
id: Q95ME4
db: uniprot

uniprot Q3ZBW5 1236
type: UnificationXref
id: Q3ZBW5
db: uniprot

SOS-1
type: ProteinReference
xref: P00193
standard name: Son of Sevenless, Drosophila, Homolog 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.SOS-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Son of Sevenless, Drosophila, Homolog 1 Synonym: SOS1 Guanine Nucleotide Exchange Factor Accession: P00193
member entity reference: Son of sevenless homolog 2
member entity reference: Ras guanine nucleotide exchange factor Y
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: Ras guanine nucleotide exchange factor B
member entity reference: Son of sevenless homolog 1
member entity reference: Protein son of sevenless
member entity reference: Uncharacterized protein
member entity reference: Ras guanine nucleotide exchange factor A
member entity reference: Ras guanine nucleotide exchange factor R

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Fibroblast growth factor receptor substrate 3
type: ProteinReference
xref: uniprot O43559 1055
organism: Homo sapiens

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q02156 612
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7FDA0 918
xref: PTHR10048:SF33
organism: Monodelphis domestica

uniprot O35800 502
type: UnificationXref
id: O35800
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot P31938 706
organism: Mus musculus

uniprot Q925I7 699
type: UnificationXref
id: Q925I7
db: uniprot

Serine/threonine-protein kinase D3
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot Q8K1Y2 628
organism: Mus musculus

uniprot E2RR18 563
type: UnificationXref
id: E2RR18
db: uniprot

NR1I2 isoform 4
type: ProteinReference
xref: uniprot A0A2I3S3V5 155
organism: Pan troglodytes

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q7PMF0 960
organism: Anopheles gambiae

Protein CBR-PXL-1
type: ProteinReference
xref: uniprot A8X7Y4 190
organism: Caenorhabditis briggsae

uniprot P97401 978
type: UnificationXref
id: P97401
db: uniprot

uniprot A0A2J8NVW7 839
type: UnificationXref
id: A0A2J8NVW7
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
control type: INHIBITION
controller: Dsh

uniprot O00750 932
type: UnificationXref
id: O00750
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 282
organism: Bos taurus

uniprot A0A3Q1MTU2 1255
type: UnificationXref
id: A0A3Q1MTU2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4Y0D3 97
organism: Strongylocentrotus purpuratus

uniprot Q9Y219 764
type: UnificationXref
id: Q9Y219
db: uniprot

uniprot H2R472 402
type: UnificationXref
id: H2R472
db: uniprot

FGF
type: Protein
entity reference: FGF
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa13 1307
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein Wnt
type: ProteinReference
xref: uniprot C3YYJ8 327
xref: PTHR12027:SF91
organism: Branchiostoma floridae

Wnt s23 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Wnt
stoichiometric coefficient: 1.0

Tissue factor
type: ProteinReference
xref: PTHR20859:SF22
xref: uniprot H2R022 149
organism: Pan troglodytes

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 68

LIM domain-containing protein B
type: ProteinReference
xref: uniprot Q54NW4 200
organism: Dictyostelium discoideum

p38MAPK
type: ProteinReference
xref: P00182
standard name: p38 Mitogen-Activated Protein Kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: p38 Mitogen-Activated Protein Kinase Synonym: CSAID-Binding Protein1,CSBP1,Cytokine-Suppressive Anti-inflammatory Drug-Binding Protein 1,MAPK14,MXI2,Mitogen-Activated Protein Kinase 14,RK,SAPK2A,Stress-Activated Protein Kinase 2A,p38,p38 MAP Kinase,p38-Alpha Accession: P00182
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.p38MAPK
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 14A
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 14B

uniprot A0A3Q1M614 1091
type: UnificationXref
id: A0A3Q1M614
db: uniprot

uniprot A0A2I3SXI2 440
type: UnificationXref
id: A0A2I3SXI2
db: uniprot

uniprot A0A1D5QK16 186
type: UnificationXref
id: A0A1D5QK16
db: uniprot

uniprot A0A2I3SLM0 679
type: UnificationXref
id: A0A2I3SLM0
db: uniprot

uniprot P57095 1201
type: UnificationXref
id: P57095
db: uniprot

Cytoplasmic protein NCK1
type: ProteinReference
xref: uniprot Q99M51 518
xref: PTHR19969:SF16
organism: Mus musculus

PDGFR s33 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PDGFR
stoichiometric coefficient: 1.0

Crk-like protein
type: ProteinReference
xref: uniprot P47941 405
xref: PTHR19969:SF20
organism: Mus musculus

uniprot H2QJ36 976
type: UnificationXref
id: H2QJ36
db: uniprot

uniprot A0A1D5Q8X5 185
type: UnificationXref
id: A0A1D5Q8X5
db: uniprot

MAP2K4 protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot A5PJP8 239
organism: Bos taurus

uniprot P28576 694
type: UnificationXref
id: P28576
db: uniprot

Nitric oxide synthase
type: ProteinReference
xref: uniprot A0A3Q1LSD1 433
xref: PTHR19384:SF66
organism: Bos taurus

Phospholipase
type: ProteinReference
xref: uniprot K7BNT4 306
xref: PTHR18896:SF121
organism: Pan troglodytes

PIP2
type: SmallMolecule
cellular location: plasma membrane
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR45836:SF12
type: RelationshipXref
id: PTHR45836:SF12
db: PANTHER Family
relationship type: By Homology

PTHR45836:SF15
type: RelationshipXref
id: PTHR45836:SF15
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Src-RIGHT__Src-_r288
controller: Complex (VEGFR-2/VEGF)

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1MAI3 164
organism: Rattus norvegicus

uniprot P13726 150
type: UnificationXref
id: P13726
db: uniprot

uniprot P22725 364
type: UnificationXref
id: P22725
db: uniprot

Frizzled class receptor 2
type: ProteinReference
xref: PTHR11309:SF34
xref: uniprot F7DIA9 123
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PS94 1257
xref: PTHR22804:SF52
organism: Canis lupus familiaris

uniprot F6Y4G8 645
type: UnificationXref
id: F6Y4G8
db: uniprot

Delta-like protein
type: ProteinReference
xref: uniprot A0A3Q2U673 717
organism: Gallus gallus

uniprot F1Q3M8 903
type: UnificationXref
id: F1Q3M8
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q02111 611
xref: PTHR24356:SF181
organism: Mus musculus

uniprot D4A9J2 331
type: UnificationXref
id: D4A9J2
db: uniprot

Dok-R
type: Protein
entity reference: Dok-R
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P27986 942
type: UnificationXref
id: P27986
db: uniprot

Platelet-derived growth factor subunit A
type: ProteinReference
xref: uniprot P28576 694
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6WES5 686
organism: Macaca mulatta

Dok-R
type: ProteinReference
xref: P00180
standard name: Docking Protein-R
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Dok-R
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Docking Protein-R Synonym: Synonym not specified Accession: P00180
member entity reference: Docking protein 3
member entity reference: Docking protein 1
member entity reference: Docking protein 2
member entity reference: Uncharacterized protein
member entity reference: DOK1 isoform 3
member entity reference: DOK2 isoform 1

Axin-1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot O35625 1196
organism: Mus musculus

uniprot Q7Q042 625
type: UnificationXref
id: Q7Q042
db: uniprot

uniprot F1MEW8 336
type: UnificationXref
id: F1MEW8
db: uniprot

uniprot F0ZVH9 997
type: UnificationXref
id: F0ZVH9
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Notch-_Delta_Serrate-RIGHT__Complex__Notch_Delta__Serrate_-_r145
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r145 1518
participant stoichiometry: PARTICIPANT STOICHIOMETRY r145 1517
participant stoichiometry: PARTICIPANT STOICHIOMETRY r145 1519
left: Delta/Serrate
left: Notch
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Notch/Delta/ Serrate)

PDGFB protein
type: ProteinReference
xref: uniprot B1H0W5 683
organism: Bos taurus

DVL3 isoform 1
type: ProteinReference
xref: uniprot H2QNU7 259
xref: PTHR10878:SF6
organism: Pan troglodytes

uniprot E1B847 414
type: UnificationXref
id: E1B847
db: uniprot

PARTICIPANT STOICHIOMETRY r294 1545
type: Stoichiometry
physical entity: p38MAPK
stoichiometric coefficient: 1.0

FGFR-1
type: ProteinReference
xref: P00186
standard name: Fibroblast Growth Factor Receptor-1
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.RECEPTOR.FGFR-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Fibroblast Growth Factor Receptor-1 Synonym: FGFR-1,FLG,FLT2,FMS-Like Gene,FMS-Like Tyrosine Kinase 2 Accession: P00186
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Fibroblast growth factor receptor 1
member entity reference: Fibroblast growth factor receptor
member entity reference: Fibroblast growth factor receptor 1-A

PARTICIPANT STOICHIOMETRY r294 1544
type: Stoichiometry
physical entity: p38MAPK
stoichiometric coefficient: 1.0

uniprot F1PDC7 1256
type: UnificationXref
id: F1PDC7
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot Q2IBD1 377
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r263 1449
type: Stoichiometry
physical entity: Grb7
stoichiometric coefficient: 1.0

Ras GTPase-activating protein 1
type: ProteinReference
xref: uniprot P20936 147
xref: PTHR10194:SF19
organism: Homo sapiens

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot A0A1D5R999 805
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r279 1392
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r263 1448
type: Stoichiometry
physical entity: Grb7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r279 1391
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot Q9JHG7 966
xref: PTHR10048:SF34
organism: Mus musculus

uniprot K7CHS6 1194
type: UnificationXref
id: K7CHS6
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot H2PZ66 80
organism: Pan troglodytes

Adenomatous polyposis coli
type: ProteinReference
xref: PTHR12607:SF11
xref: uniprot F6XK08 212
organism: Xenopus tropicalis

uniprot E2RQM0 1275
type: UnificationXref
id: E2RQM0
db: uniprot

Protein jagged-2
type: ProteinReference
xref: PTHR24044:SF421
xref: uniprot Q9QYE5 762
organism: Mus musculus

uniprot F7CU42 1162
type: UnificationXref
id: F7CU42
db: uniprot

JAK1
type: Protein
entity reference: JAK1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Angiopoietin-2
type: ProteinReference
xref: uniprot O35608 1134
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r270 1416
type: Stoichiometry
physical entity: Nck
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r270 1417
type: Stoichiometry
physical entity: Nck
stoichiometric coefficient: 1.0

Putative glycogen synthase kinase-3 homolog
type: ProteinReference
xref: uniprot P83101 450
organism: Drosophila melanogaster

uniprot P78504 745
type: UnificationXref
id: P78504
db: uniprot

uniprot H2QP14 1165
type: UnificationXref
id: H2QP14
db: uniprot

Ang-1
type: Protein
entity reference: Ang-1
comment: SPECIES_TYPE=PROTEIN

PAR
type: Protein
entity reference: PAR
feature: COMPLEX PARTICIPANT BINDING FEATURE s222 a8 1313
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Ephrin-B2
type: ProteinReference
xref: PTHR11304:SF18
xref: uniprot P52800 1040
organism: Mus musculus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF73
xref: uniprot A0A0G2K3B7 315
organism: Rattus norvegicus

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05771 594
organism: Homo sapiens

uniprot P08134 1223
type: UnificationXref
id: P08134
db: uniprot

Fibroblast growth factor receptor 1
type: ProteinReference
xref: uniprot P16092 70
xref: PTHR24416:SF131
organism: Mus musculus

Nitric oxide synthase
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot A0A1D5QGM1 432
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot A0A1D5R985 547
organism: Macaca mulatta

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot Q1LZB2 516
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E2RNP2 562
organism: Canis lupus familiaris

uniprot H2RA86 290
type: UnificationXref
id: H2RA86
db: uniprot

Frizzled class receptor 5
type: ProteinReference
xref: uniprot F1MGM1 115
xref: PTHR11309:SF136
organism: Bos taurus

PDGFR
type: ProteinReference
xref: P00230
standard name: Platelet-Derived Growth Factor Receptor
comment: ENTITY_REFERENCE_NOTES=Long Name: Platelet-Derived Growth Factor Receptor Synonym: PDGFRA,PDGFRB Accession: P00230
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.RECEPTOR.PDGFR
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Platelet-derived growth factor receptor alpha
member entity reference: Platelet-derived growth factor receptor beta

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 61

Akt
type: Protein
entity reference: Akt
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

LOC100170599 protein
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot B3DM35 102
organism: Xenopus tropicalis

uniprot Q9BZL6 630
type: UnificationXref
id: Q9BZL6
db: uniprot

uniprot Q62101 623
type: UnificationXref
id: Q62101
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F3S0 917
xref: PTHR10048:SF33
organism: Macaca mulatta

uniprot H9EU39 586
type: UnificationXref
id: H9EU39
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot Q62925 419
xref: PTHR24361:SF414
organism: Rattus norvegicus

uniprot Q9HF54 1250
type: UnificationXref
id: Q9HF54
db: uniprot

uniprot E2QYK5 870
type: UnificationXref
id: E2QYK5
db: uniprot

EPH receptor B2
type: ProteinReference
xref: uniprot A0A2I3RJ07 457
xref: PTHR24416:SF123
organism: Pan troglodytes

uniprot P31240 695
type: UnificationXref
id: P31240
db: uniprot

uniprot F7GNE4 89
type: UnificationXref
id: F7GNE4
db: uniprot

uniprot P61149 496
type: UnificationXref
id: P61149
db: uniprot

uniprot O00443 930
type: UnificationXref
id: O00443
db: uniprot

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot Q13153 1170
xref: PTHR48015:SF20
organism: Homo sapiens

uniprot P23458 82
type: UnificationXref
id: P23458
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H2PXY8 924
xref: PTHR10048:SF35
organism: Pan troglodytes

STATE_TRANSITION_LEFT__STAT3-RIGHT__STAT3-_r254
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r254 1473
participant stoichiometry: PARTICIPANT STOICHIOMETRY r254 1474
left: STAT3
interaction type: STATE_TRANSITION
right: STAT3

uniprot E9PYG6 142
type: UnificationXref
id: E9PYG6
db: uniprot

Nitric oxide synthase
type: ProteinReference
xref: uniprot H2QVM2 435
xref: PTHR19384:SF66
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ets-RIGHT__Ets-_r275
controller: Erk

STATE_TRANSITION_LEFT__Erk-RIGHT__Erk-_r278
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r278 1393
participant stoichiometry: PARTICIPANT STOICHIOMETRY r278 1394
left: Erk
interaction type: STATE_TRANSITION
right: Erk

Proto-oncogene Wnt-1
type: ProteinReference
xref: uniprot P04426 359
xref: PTHR12027:SF91
organism: Mus musculus

uniprot B8JMI2 248
type: UnificationXref
id: B8JMI2
db: uniprot

uniprot P31750 667
type: UnificationXref
id: P31750
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re109
controller: Complex (Axin/APC/ GSK3beta)

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P16054 599
organism: Mus musculus

uniprot P67964 1061
type: UnificationXref
id: P67964
db: uniprot

Coagulation factor VII
type: ProteinReference
xref: PTHR24278:SF26
xref: uniprot F1QFP3 274
organism: Danio rerio

uniprot Q3MHZ4 199
type: UnificationXref
id: Q3MHZ4
db: uniprot

uniprot O43294 194
type: UnificationXref
id: O43294
db: uniprot

uniprot F1PBB6 241
type: UnificationXref
id: F1PBB6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GDI5 734
organism: Macaca mulatta

PTHR19384:SF66
type: RelationshipXref
id: PTHR19384:SF66
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF133
xref: uniprot F1NHI6 970
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RKF7 120
xref: PTHR11309:SF34
organism: Monodelphis domestica

uniprot F6PGQ1 444
type: UnificationXref
id: F6PGQ1
db: uniprot

Ang-1
type: Protein
entity reference: Ang-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s226 sa236 1299
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A4GT58 1108
type: UnificationXref
id: A4GT58
db: uniprot

Growth factor receptor-bound protein 7
type: ProteinReference
xref: PTHR11243:SF25
xref: uniprot Q9QZC5 784
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r145 1517
type: Stoichiometry
physical entity: Notch
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r145 1519
type: Stoichiometry
physical entity: Complex (Notch/Delta/ Serrate)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r145 1518
type: Stoichiometry
physical entity: Delta/Serrate
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ES59 1214
xref: PTHR24072:SF100
organism: Monodelphis domestica

uniprot P70478 216
type: UnificationXref
id: P70478
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NCY7 1092
organism: Gallus gallus

Dishevelled segment polarity protein 3
type: ProteinReference
xref: uniprot D4ADV8 250
xref: PTHR10878:SF6
organism: Rattus norvegicus

Caspase 9, isoform CRA_a
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot Q9JHK1 523
organism: Rattus norvegicus

uniprot P25116 158
type: UnificationXref
id: P25116
db: uniprot

uniprot P32252 1015
type: UnificationXref
id: P32252
db: uniprot

Ephrin-B1
type: ProteinReference
xref: uniprot P52795 1037
organism: Mus musculus

uniprot A0A2I3S3A1 779
type: UnificationXref
id: A0A2I3S3A1
db: uniprot

uniprot G3N2W8 125
type: UnificationXref
id: G3N2W8
db: uniprot

uniprot O00755 357
type: UnificationXref
id: O00755
db: uniprot

uniprot Q924A0 1064
type: UnificationXref
id: Q924A0
db: uniprot

uniprot H2R5K3 416
type: UnificationXref
id: H2R5K3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK1-RIGHT__JNK1-_r153
controller: JNKK1

uniprot F6QXG9 1128
type: UnificationXref
id: F6QXG9
db: uniprot

Protein serrate
type: ProteinReference
xref: uniprot P18168 744
organism: Drosophila melanogaster

uniprot Q5TP56 382
type: UnificationXref
id: Q5TP56
db: uniprot

uniprot O70421 129
type: UnificationXref
id: O70421
db: uniprot

eco ECO:0000501 387
type: UnificationXref
id: ECO:0000501
db: eco

DISSOCIATION
type: InteractionVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r230
controller: GAP

uniprot F6WLE6 425
type: UnificationXref
id: F6WLE6
db: uniprot

PTHR45808:SF6
type: RelationshipXref
id: PTHR45808:SF6
db: PANTHER Family
relationship type: By Homology

ncbitaxon 45351 989
type: UnificationXref
id: 45351
db: ncbitaxon

ncbitaxon 10228 1210
type: UnificationXref
id: 10228
db: ncbitaxon

uniprot P02511 821
type: UnificationXref
id: P02511
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 1070
xref: PTHR44329:SF22
xref: uniprot Q99N57 1090
organism: Mus musculus

Recombination signal-binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: uniprot F7BXC9 846
xref: PTHR10665:SF3
organism: Xenopus tropicalis

uniprot Q6MG89 1267
type: UnificationXref
id: Q6MG89
db: uniprot

Ephrin-B1
type: ProteinReference
xref: uniprot P52796 1038
organism: Rattus norvegicus

Ephrin-B2
type: ProteinReference
xref: uniprot P52799 1039
xref: PTHR11304:SF18
organism: Homo sapiens

uniprot F7CRM0 465
type: UnificationXref
id: F7CRM0
db: uniprot

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

uniprot F7DY09 487
type: UnificationXref
id: F7DY09
db: uniprot

Fzd
type: Protein
entity reference: Fzd
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F0ZI47 996
type: UnificationXref
id: F0ZI47
db: uniprot

uniprot P63318 608
type: UnificationXref
id: P63318
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11304:SF18
xref: uniprot F7F3Y7 1033
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HDY6 469
organism: Macaca mulatta

uniprot P08646 1012
type: UnificationXref
id: P08646
db: uniprot

uniprot A0A1D5R985 547
type: UnificationXref
id: A0A1D5R985
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6Y4G8 645
xref: PTHR24055:SF222
organism: Canis lupus familiaris

uniprot P52332 83
type: UnificationXref
id: P52332
db: uniprot

uniprot P18870 545
type: UnificationXref
id: P18870
db: uniprot

uniprot O15392 233
type: UnificationXref
id: O15392
db: uniprot

uniprot P52796 1038
type: UnificationXref
id: P52796
db: uniprot

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: uniprot F6RSC1 788
organism: Xenopus tropicalis

uniprot P31695 1263
type: UnificationXref
id: P31695
db: uniprot

uniprot Q63768 408
type: UnificationXref
id: Q63768
db: uniprot

STAT3
type: Protein
entity reference: STAT3
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot P08642 1011
organism: Gallus gallus

uniprot O88671 742
type: UnificationXref
id: O88671
db: uniprot

Ras-like protein 1
type: ProteinReference
xref: uniprot P08646 1012
organism: Drosophila melanogaster

uniprot A8WTA3 1109
type: UnificationXref
id: A8WTA3
db: uniprot

uniprot C3YYJ8 327
type: UnificationXref
id: C3YYJ8
db: uniprot

SH2 domain-containing protein 2A
type: ProteinReference
evidence: Evidence 225
xref: uniprot Q9NP31 224
xref: PTHR14388:SF9
organism: Homo sapiens

uniprot P22457 276
type: UnificationXref
id: P22457
db: uniprot

Neurogenic locus notch homolog protein 1
type: ProteinReference
xref: uniprot Q07008 1266
xref: PTHR22804:SF52
organism: Rattus norvegicus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF98
xref: uniprot Q7PM77 383
organism: Anopheles gambiae

Axin s27 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Axin
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__STAT1-RIGHT__STAT1-_r178
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r178 1406
participant stoichiometry: PARTICIPANT STOICHIOMETRY r178 1407
left: STAT1
interaction type: STATE_TRANSITION
right: STAT1

Complex (c-Jun/c-Fos)
type: Complex
component stoichiometry: c Jun s16 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: c Fos s17 sa4 STOICHIOMETRY ID COMPLEX
component: c-Jun
component: c-Fos
feature: COMPLEX BINDING FEATURE s154 a166 1322
feature: COMPLEX BINDING FEATURE s154 a166 1324
cellular location: nuclear membrane

uniprot E2RGU7 561
type: UnificationXref
id: E2RGU7
db: uniprot

Serine/threonine-protein kinase dkf-2
type: ProteinReference
xref: uniprot O45818 588
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot A0A1D5QXL5 99
organism: Macaca mulatta

uniprot F7DI28 344
type: UnificationXref
id: F7DI28
db: uniprot

uniprot Q7Q723 832
type: UnificationXref
id: Q7Q723
db: uniprot

uniprot E2RF98 396
type: UnificationXref
id: E2RF98
db: uniprot

uniprot Q61194 953
type: UnificationXref
id: Q61194
db: uniprot

uniprot F6QM53 904
type: UnificationXref
id: F6QM53
db: uniprot

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot F1QNG4 1001
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR11243:SF25
xref: uniprot F7HEB2 781
organism: Macaca mulatta

uniprot H2QVM2 435
type: UnificationXref
id: H2QVM2
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: uniprot P09217 597
xref: PTHR24356:SF170
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P09216 596
organism: Rattus norvegicus

uniprot F6PX17 1094
type: UnificationXref
id: F6PX17
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P09215 595
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F1MYM3 901
organism: Bos taurus

AGAP007158-PA
type: ProteinReference
xref: uniprot Q7PCM8 830
organism: Anopheles gambiae

uniprot Q9QW30 1269
type: UnificationXref
id: Q9QW30
db: uniprot

uniprot Q8BTI9 962
type: UnificationXref
id: Q8BTI9
db: uniprot

uniprot Q9WUD9 62
type: UnificationXref
id: Q9WUD9
db: uniprot

uniprot P63319 609
type: UnificationXref
id: P63319
db: uniprot

Phospholipase D2
type: ProteinReference
xref: PTHR18896:SF121
xref: uniprot P97813 310
organism: Mus musculus

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P34722 605
organism: Caenorhabditis elegans

uniprot B1WAZ6 1180
type: UnificationXref
id: B1WAZ6
db: uniprot

uniprot F7BUW7 256
type: UnificationXref
id: F7BUW7
db: uniprot

Phospholipase D2
type: ProteinReference
xref: PTHR18896:SF121
xref: uniprot Q0V8L6 311
organism: Bos taurus

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF421
xref: uniprot E9PU23 724
organism: Rattus norvegicus

Delta-like protein D
type: ProteinReference
xref: uniprot Q8UWJ4 754
xref: PTHR24044:SF380
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E313 635
xref: PTHR24416:SF45
organism: Macaca mulatta

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r232
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r232 1533
participant stoichiometry: PARTICIPANT STOICHIOMETRY r232 1534
left: MEK
interaction type: STATE_TRANSITION
right: MEK

uniprot O08674 848
type: UnificationXref
id: O08674
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7H3B3 579
xref: PTHR24356:SF162
organism: Macaca mulatta

Axin
type: ProteinReference
xref: P00253
standard name: Axis inhibitor 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Axis inhibitor 1 Synonym: Fused Accession: P00253
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Axin
member entity reference: Uncharacterized protein
member entity reference: Axin-1
member entity reference: Axin 1
member entity reference: Axin-2
member entity reference: AGAP002123-PA
member entity reference: Axin 2

uniprot G2HHN0 511
type: UnificationXref
id: G2HHN0
db: uniprot

Rho-related GTP-binding protein RhoB
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot Q3ZBW5 1236
organism: Bos taurus

Fibroblast growth factor receptor substrate 3
type: ProteinReference
xref: uniprot J9NT83 1054
organism: Canis lupus familiaris

Cytosolic phospholipase A2 beta
type: ProteinReference
xref: uniprot P0C869 1185
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot J9P2Q5 352
organism: Canis lupus familiaris

PDGF
type: ProteinReference
xref: P00224
standard name: Platelet-Derived Growth Factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Platelet-Derived Growth Factor Synonym: PDGFA,PDGFB,PDGFC,PDGFD Accession: P00224
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.PDGF
member entity reference: Platelet-derived growth factor D
member entity reference: Platelet-derived growth factor C
member entity reference: Platelet-derived growth factor A chain long form
member entity reference: PDGFC isoform 1
member entity reference: Platelet derived growth factor C
member entity reference: Platelet-derived growth factor subunit A
member entity reference: Platelet-derived growth factor alpha polypeptide a
member entity reference: PDGFB isoform 1
member entity reference: PDGFD protein
member entity reference: Uncharacterized protein
member entity reference: PDGFD isoform 1
member entity reference: Platelet-derived growth factor subunit B
member entity reference: PDGFB protein

uniprot Q9UBG7 854
type: UnificationXref
id: Q9UBG7
db: uniprot

uniprot A0A2J8QY32 886
type: UnificationXref
id: A0A2J8QY32
db: uniprot

uniprot A5PJP8 239
type: UnificationXref
id: A5PJP8
db: uniprot

uniprot H2QVQ1 1131
type: UnificationXref
id: H2QVQ1
db: uniprot

Ang-1
type: Protein
entity reference: Ang-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s226 sa21 1303
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

Alpha-crystallin A chain
type: ProteinReference
xref: uniprot P02489 818
organism: Homo sapiens

BAD
type: Protein
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5Q5Z6 280
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

PTHR24044:SF448
type: RelationshipXref
id: PTHR24044:SF448
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot F1NHL1 569
xref: PTHR22968:SF9
organism: Gallus gallus

PTHR12027:SF112
type: RelationshipXref
id: PTHR12027:SF112
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SPK-RIGHT__SPK-_r283
controller: PKC

uniprot P06780 1221
type: UnificationXref
id: P06780
db: uniprot

uniprot Q02858 1149
type: UnificationXref
id: Q02858
db: uniprot

uniprot F6V332 28
type: UnificationXref
id: F6V332
db: uniprot

uniprot A0A3Q1N3Z8 786
type: UnificationXref
id: A0A3Q1N3Z8
db: uniprot

GSK3beta s29 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GSK3beta
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Erk-RIGHT__Erk-_r233
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r233 1530
participant stoichiometry: PARTICIPANT STOICHIOMETRY r233 1529
left: Erk
interaction type: STATE_TRANSITION
right: Erk

uniprot Q6P0S4 877
type: UnificationXref
id: Q6P0S4
db: uniprot

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q28EW2 1020
organism: Xenopus tropicalis

uniprot B8JKB8 459
type: UnificationXref
id: B8JKB8
db: uniprot

uniprot F1P9P1 463
type: UnificationXref
id: F1P9P1
db: uniprot

uniprot P57094 1200
type: UnificationXref
id: P57094
db: uniprot

Angiopoietin 2
type: ProteinReference
xref: PTHR19143:SF199
xref: uniprot F7G4Q4 1130
organism: Monodelphis domestica

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1MYJ4 657
organism: Bos taurus

PTHR24044:SF450
type: RelationshipXref
id: PTHR24044:SF450
db: PANTHER Family
relationship type: By Homology

uniprot Q9XYM0 413
type: UnificationXref
id: Q9XYM0
db: uniprot

Alpha-crystallin A chain
type: ProteinReference
xref: uniprot P02470 817
organism: Bos taurus

uniprot F7ELA0 467
type: UnificationXref
id: F7ELA0
db: uniprot

PARTICIPANT STOICHIOMETRY r247 1505
type: Stoichiometry
physical entity: GAP
stoichiometric coefficient: 1.0

uniprot F7DVL1 576
type: UnificationXref
id: F7DVL1
db: uniprot

PARTICIPANT STOICHIOMETRY r247 1506
type: Stoichiometry
physical entity: GAP
stoichiometric coefficient: 1.0

uniprot Q9Z1L0 968
type: UnificationXref
id: Q9Z1L0
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot M0R9D3 354
organism: Rattus norvegicus

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: PTHR21258:SF40
xref: uniprot E2QSI0 1050
organism: Canis lupus familiaris

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

C-fos
type: ProteinReference
xref: uniprot A5A6H0 868
xref: PTHR23351:SF4
organism: Pan troglodytes

uniprot A0A1D5NXB2 246
type: UnificationXref
id: A0A1D5NXB2
db: uniprot

Delta-like protein 4
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot Q9JI71 758
organism: Mus musculus

AGAP005548-PA
type: ProteinReference
xref: uniprot Q7Q723 832
organism: Anopheles gambiae

AGAP005547-PA
type: ProteinReference
xref: uniprot Q7Q724 833
organism: Anopheles gambiae

C-fos
type: ProteinReference
xref: uniprot A5A6H2 869
xref: PTHR23351:SF4
organism: Macaca mulatta

uniprot F6Y841 911
type: UnificationXref
id: F6Y841
db: uniprot

uniprot P00523 54
type: UnificationXref
id: P00523
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot H2QNG6 927
xref: PTHR10048:SF33
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F1Q4F8 658
organism: Canis lupus familiaris

uniprot F1PGJ9 685
type: UnificationXref
id: F1PGJ9
db: uniprot

uniprot P54674 949
type: UnificationXref
id: P54674
db: uniprot

uniprot Q9Y1T2 219
type: UnificationXref
id: Q9Y1T2
db: uniprot

uniprot Q64010 409
type: UnificationXref
id: Q64010
db: uniprot

uniprot Q07889 177
type: UnificationXref
id: Q07889
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot A0A0B4KHC3 546
organism: Drosophila melanogaster

PTHR24044:SF470
type: RelationshipXref
id: PTHR24044:SF470
db: PANTHER Family
relationship type: By Homology

uniprot H2R022 149
type: UnificationXref
id: H2R022
db: uniprot

uniprot F7F5K9 1003
type: UnificationXref
id: F7F5K9
db: uniprot

PARTICIPANT STOICHIOMETRY r153 1495
type: Stoichiometry
physical entity: JNK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r153 1494
type: Stoichiometry
physical entity: JNK1
stoichiometric coefficient: 1.0

uniprot P34152 428
type: UnificationXref
id: P34152
db: uniprot

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r279
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r279 1391
participant stoichiometry: PARTICIPANT STOICHIOMETRY r279 1392
left: MEK
interaction type: STATE_TRANSITION
right: MEK

uniprot Q9VXH3 1287
type: UnificationXref
id: Q9VXH3
db: uniprot

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: uniprot Q13177 1171
xref: PTHR48015:SF22
organism: Homo sapiens

uniprot F1PS03 1276
type: UnificationXref
id: F1PS03
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r175
controller: Complex (EphR/Eph)

Tissue factor
type: ProteinReference
xref: PTHR20859:SF22
xref: uniprot P13726 150
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FRS_2-RIGHT__FRS_2-_r223
controller: Crk

RIKEN cDNA 4930544G11
type: ProteinReference
xref: uniprot Q9CR99 1248
organism: Mus musculus

uniprot F7C1Q4 730
type: UnificationXref
id: F7C1Q4
db: uniprot

uniprot A0A1D5QLW6 1270
type: UnificationXref
id: A0A1D5QLW6
db: uniprot

uniprot Q8K1Y2 628
type: UnificationXref
id: Q8K1Y2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ATU3 814
organism: Monodelphis domestica

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 1067
xref: PTHR44329:SF22
xref: uniprot P04049 1079
organism: Homo sapiens

SH2 domain-containing protein 2A
type: ProteinReference
evidence: Evidence 225
xref: uniprot Q9QXK9 226
xref: PTHR14388:SF9
organism: Mus musculus

uniprot Q9QXK9 226
type: UnificationXref
id: Q9QXK9
db: uniprot

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

uniprot Q7YQL4 1176
type: UnificationXref
id: Q7YQL4
db: uniprot

uniprot Q9C3Y4 1246
type: UnificationXref
id: Q9C3Y4
db: uniprot

PTHR11309:SF133
type: RelationshipXref
id: PTHR11309:SF133
db: PANTHER Family
relationship type: By Homology

uniprot Q1RMJ6 1232
type: UnificationXref
id: Q1RMJ6
db: uniprot

PTHR11309:SF136
type: RelationshipXref
id: PTHR11309:SF136
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

uniprot O08680 471
type: UnificationXref
id: O08680
db: uniprot

uniprot P14602 823
type: UnificationXref
id: P14602
db: uniprot

PTHR11309:SF139
type: RelationshipXref
id: PTHR11309:SF139
db: PANTHER Family
relationship type: By Homology

MAPKAPK2/3
type: ProteinReference
xref: P00244
standard name: Mitogen-activated protein kinase-activated protein kinase 2 and 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.MAPKAPK2/3
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen-Activated Protein Kinase-Activating Protein Kinase-2 and 3 Synonym: 3PK,MAPKAP Kinase 2/3,MAPKAP2/3 Accession: P00244
member entity reference: Mitogen-activated protein kinase-activated protein kinase 2
member entity reference: MAP kinase-activated protein kinase 3
member entity reference: Uncharacterized protein
member entity reference: MAP kinase-activated protein kinase 2
member entity reference: MAPKAPK2 isoform 1
member entity reference: MAPKAPK3 isoform 1
member entity reference: MAP kinase-activated protein kinase mak-2
member entity reference: AGAP011890-PA (Fragment)

uniprot Q04982 1088
type: UnificationXref
id: Q04982
db: uniprot

STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r259
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r259 1460
participant stoichiometry: PARTICIPANT STOICHIOMETRY r259 1461
left: Akt
interaction type: STATE_TRANSITION
right: Akt

uniprot Q90Z00 74
type: UnificationXref
id: Q90Z00
db: uniprot

PARTICIPANT STOICHIOMETRY r292 1549
type: Stoichiometry
physical entity: HSP27
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r292 1548
type: Stoichiometry
physical entity: HSP27
stoichiometric coefficient: 1.0

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF140
type: RelationshipXref
id: PTHR11309:SF140
db: PANTHER Family
relationship type: By Homology

PTHR11309:SF141
type: RelationshipXref
id: PTHR11309:SF141
db: PANTHER Family
relationship type: By Homology

Erk
type: Protein
entity reference: Erk
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Phospholipase A2
type: ProteinReference
evidence: Evidence 766
xref: PTHR10728:SF13
xref: uniprot F7CBU9 769
organism: Monodelphis domestica

Neurogenic locus notch homolog protein 4
type: ProteinReference
xref: uniprot P31695 1263
xref: PTHR24044:SF470
organism: Mus musculus

uniprot F6W3Y0 1159
type: UnificationXref
id: F6W3Y0
db: uniprot

uniprot F7BZL6 914
type: UnificationXref
id: F7BZL6
db: uniprot

uniprot Q7QG48 411
type: UnificationXref
id: Q7QG48
db: uniprot

Cytoplasmic protein NCK2
type: ProteinReference
xref: uniprot O43639 513
xref: PTHR19969:SF12
organism: Homo sapiens

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1MSP9 550
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

Secreted frizzled-related protein 3
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot P97401 978
organism: Mus musculus

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

uniprot Q13153 1170
type: UnificationXref
id: Q13153
db: uniprot

uniprot P07207 1262
type: UnificationXref
id: P07207
db: uniprot

uniprot Q17850 1172
type: UnificationXref
id: Q17850
db: uniprot

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

uniprot Q1MT43 1142
type: UnificationXref
id: Q1MT43
db: uniprot

Cell death abnormality protein 2
type: ProteinReference
xref: uniprot Q9NHC3 412
organism: Caenorhabditis elegans

Ang-2
type: Protein
entity reference: Ang-2
comment: SPECIES_TYPE=PROTEIN

Protein Wnt
type: ProteinReference
xref: uniprot A0A2J8LQ70 322
xref: PTHR12027:SF91
organism: Pan troglodytes

PLC-gamma
type: ProteinReference
xref: P00256
standard name: Phospholipase C-gamma
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.PLC-_gamma_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phospholipase C-gamma Synonym: PLC1,PLC148,PLCG1,Phospholipase C-148 Accession: P00256
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Dok_R-RIGHT__Dok_R-_r271
controller: Complex (Tie2/Ang-1)

Uncharacterized protein
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot E1B847 414
organism: Bos taurus

Cytoplasmic protein
type: ProteinReference
xref: uniprot G2HHN0 511
xref: PTHR19969:SF16
organism: Pan troglodytes

uniprot O35516 1261
type: UnificationXref
id: O35516
db: uniprot

STATE_TRANSITION_LEFT__JNK1-RIGHT__JNK1-_r153
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r153 1495
participant stoichiometry: PARTICIPANT STOICHIOMETRY r153 1494
left: JNK1
interaction type: STATE_TRANSITION
right: JNK1

Cytoplasmic protein
type: ProteinReference
xref: uniprot F7ALW1 508
xref: PTHR19969:SF12
organism: Monodelphis domestica

uniprot Q91Y86 650
type: UnificationXref
id: Q91Y86
db: uniprot

uniprot P51141 263
type: UnificationXref
id: P51141
db: uniprot

eNOS
type: ProteinReference
xref: P00210
standard name: endothelial nitric oxide synthase
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.eNOS
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: endothelial nitric oxide synthase Synonym: NOS3,Nitric Oxide Synthase 3,eNOS Accession: P00210
member entity reference: Nitric oxide synthase
member entity reference: Nitric oxide synthase, endothelial

Platelet-derived growth factor receptor beta
type: ProteinReference
xref: uniprot P09619 791
xref: PTHR24416:SF53
organism: Homo sapiens

Platelet-derived growth factor subunit A
type: ProteinReference
xref: PTHR11633:SF3
xref: uniprot P04085 692
organism: Homo sapiens

Protein wingless
type: ProteinReference
xref: PTHR12027:SF91
xref: uniprot P09615 362
organism: Drosophila melanogaster

Proteinase-activated receptor 1
type: ProteinReference
xref: uniprot P25116 158
organism: Homo sapiens

Fibroblast growth factor receptor substrate 3
type: ProteinReference
xref: uniprot F7DJK6 1051
organism: Macaca mulatta

uniprot P54675 950
type: UnificationXref
id: P54675
db: uniprot

PARTICIPANT STOICHIOMETRY r203 1438
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

uniprot P62747 1229
type: UnificationXref
id: P62747
db: uniprot

PARTICIPANT STOICHIOMETRY r203 1439
type: Stoichiometry
physical entity: PLC-gamma
stoichiometric coefficient: 1.0

uniprot A0A1D5QAU9 238
type: UnificationXref
id: A0A1D5QAU9
db: uniprot

uniprot H2Q3I0 1115
type: UnificationXref
id: H2Q3I0
db: uniprot

Delta-like protein 3
type: ProteinReference
xref: PTHR24044:SF308
xref: uniprot O88671 742
organism: Rattus norvegicus

Neurogenic locus notch homolog protein 1
type: ProteinReference
xref: PTHR45836:SF12
xref: uniprot P46531 1264
organism: Homo sapiens

uniprot Q9U6V0 392
type: UnificationXref
id: Q9U6V0
db: uniprot

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r182
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r182 1386
participant stoichiometry: PARTICIPANT STOICHIOMETRY r182 1385
left: MEK
interaction type: STATE_TRANSITION
right: MEK

Uncharacterized protein
type: ProteinReference
evidence: Evidence 1067
evidence: Evidence 1070
evidence: Evidence 1068
evidence: Evidence 1069
xref: PTHR44329:SF22
xref: uniprot A0A1D5R9U8 1066
organism: Macaca mulatta

Crystallin alpha B
type: ProteinReference
xref: uniprot E2RNB6 808
organism: Canis lupus familiaris

uniprot A0A3Q2U4X3 654
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

uniprot P16885 1282
type: UnificationXref
id: P16885
db: uniprot

uniprot Q09163 748
type: UnificationXref
id: Q09163
db: uniprot

CRK like proto-oncogene, adaptor protein
type: ProteinReference
xref: uniprot F1P241 397
xref: PTHR19969:SF20
organism: Gallus gallus

DVL2 isoform 1
type: ProteinReference
xref: uniprot H2QC24 258
xref: PTHR10878:SF8
organism: Pan troglodytes

uniprot F7E823 285
type: UnificationXref
id: F7E823
db: uniprot

PTHR46102:SF1
type: RelationshipXref
id: PTHR46102:SF1
db: PANTHER Family
relationship type: By Homology

uniprot B3RIM6 1209
type: UnificationXref
id: B3RIM6
db: uniprot

PTHR46102:SF3
type: RelationshipXref
id: PTHR46102:SF3
db: PANTHER Family
relationship type: By Homology

HIF-1
type: Protein
entity reference: HIF-1
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QGM1 432
type: UnificationXref
id: A0A1D5QGM1
db: uniprot

Protein Wnt-5a
type: ProteinReference
xref: uniprot Q9QXQ7 391
xref: PTHR12027:SF33
organism: Rattus norvegicus

uniprot E9PU23 724
type: UnificationXref
id: E9PU23
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot A0A2J8LQ46 321
xref: PTHR12027:SF76
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r177 1411
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

Raf homolog serine/threonine-protein kinase Raf
type: ProteinReference
xref: uniprot P11346 1084
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r177 1410
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

uniprot H2QD74 126
type: UnificationXref
id: H2QD74
db: uniprot

Nitric oxide synthase, endothelial
type: ProteinReference
xref: uniprot P29474 436
xref: PTHR19384:SF66
organism: Homo sapiens

PTHR46771:SF3
type: RelationshipXref
id: PTHR46771:SF3
db: PANTHER Family
relationship type: By Homology

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 1069
xref: PTHR44329:SF22
xref: uniprot P11345 1083
organism: Rattus norvegicus

ncbitaxon 284591 1240
type: UnificationXref
id: 284591
db: ncbitaxon

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

Angiopoietin-1
type: ProteinReference
xref: uniprot Q15389 1141
xref: PTHR19143:SF156
organism: Homo sapiens

uniprot F7EN59 975
type: UnificationXref
id: F7EN59
db: uniprot

STATE_TRANSITION_LEFT__GRB2-RIGHT__GRB2-_r225
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r225 1343
participant stoichiometry: PARTICIPANT STOICHIOMETRY r225 1342
left: GRB2
interaction type: STATE_TRANSITION
right: GRB2

ncbitaxon 6239 265
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot F7G8G5 528
type: UnificationXref
id: F7G8G5
db: uniprot

uniprot G7MGQ5 923
type: UnificationXref
id: G7MGQ5
db: uniprot

Platelet-derived growth factor receptor beta
type: ProteinReference
xref: uniprot Q05030 795
organism: Rattus norvegicus

plasma membrane
type: CellularLocationVocabulary
xref: GO GO:0005886 4

Mitogen-activated protein kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot A0A3Q1M614 1091
xref: PTHR24349:SF63
organism: Bos taurus

ncbitaxon 6238 191
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot P09217 597
type: UnificationXref
id: P09217
db: uniprot

uniprot A8XPY6 857
type: UnificationXref
id: A8XPY6
db: uniprot

Baculoviral IAP repeat-containing protein 5
type: ProteinReference
xref: uniprot O70201 234
xref: PTHR10044:SF166
organism: Mus musculus

PTHR23351:SF4
type: RelationshipXref
id: PTHR23351:SF4
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

uniprot Q08012 860
type: UnificationXref
id: Q08012
db: uniprot

uniprot Q06807 1150
type: UnificationXref
id: Q06807
db: uniprot

Fibroblast growth factor 1
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot P03968 488
organism: Bos taurus

Ras-like protein rasD
type: ProteinReference
xref: uniprot P03967 1009
organism: Dictyostelium discoideum

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot O88643 1167
xref: PTHR48015:SF20
organism: Mus musculus

uniprot A0A2I3RJ07 457
type: UnificationXref
id: A0A2I3RJ07
db: uniprot

ncbitaxon 7165 61
type: UnificationXref
id: 7165
db: ncbitaxon

Transforming growth factor beta-1-induced transcript 1 protein
type: ProteinReference
xref: uniprot Q99PD6 208
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_r297
control type: ACTIVATION
controller: IP3

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: PTHR21258:SF40
xref: uniprot A0A0G2JZZ5 1044
organism: Rattus norvegicus

uniprot P05625 1081
type: UnificationXref
id: P05625
db: uniprot

PTHR24049:SF18
type: RelationshipXref
id: PTHR24049:SF18
db: PANTHER Family
relationship type: By Homology

uniprot Q9CXP4 1125
type: UnificationXref
id: Q9CXP4
db: uniprot

Fibroblast growth factor receptor 1
type: ProteinReference
xref: uniprot P11362 69
xref: PTHR24416:SF131
organism: Homo sapiens

uniprot F7HHY8 1096
type: UnificationXref
id: F7HHY8
db: uniprot

uniprot H2Q0T0 772
type: UnificationXref
id: H2Q0T0
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 3
type: ProteinReference
xref: uniprot A0A2I3RH39 882
xref: PTHR10155:SF2
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GRB2-RIGHT__GRB2-_r225
controller: Complex (PDGFR/PDGF)

Alpha A crystallin
type: ProteinReference
xref: uniprot Q8UUZ6 834
organism: Danio rerio

uniprot G5EDU3 303
type: UnificationXref
id: G5EDU3
db: uniprot

VRAP
type: Protein
entity reference: VRAP
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r299 1525
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r299 1526
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot G5E577 704
organism: Bos taurus

STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r180
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r180 1389
participant stoichiometry: PARTICIPANT STOICHIOMETRY r180 1390
left: Ras
interaction type: STATE_TRANSITION
right: Ras

Protein son of sevenless
type: ProteinReference
xref: uniprot P26675 175
organism: Drosophila melanogaster

Proteinase-activated receptor 1
type: ProteinReference
xref: uniprot P30558 160
organism: Mus musculus

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot E1B7L9 555
organism: Bos taurus

Docking protein 1
type: ProteinReference
xref: uniprot P97465 20
organism: Mus musculus

Ets
type: ProteinReference
xref: P00188
standard name: v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: v-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1 Synonym: Ets1 Oncogene Accession: P00188
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Ets
member entity reference: ETS proto-oncogene 1, transcription factor
member entity reference: Uncharacterized protein
member entity reference: Protein C-ets-1
member entity reference: LOC100170599 protein

Ras-like GTP-binding protein Rho1
type: ProteinReference
xref: uniprot P48148 1224
organism: Drosophila melanogaster

uniprot P61148 495
type: UnificationXref
id: P61148
db: uniprot

uniprot A0A0G2K3B7 315
type: UnificationXref
id: A0A0G2K3B7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r261
controller: Shp-2

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5R9X3 534
xref: PTHR11801:SF18
organism: Macaca mulatta

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot F7GTQ2 578
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR19969:SF8
xref: uniprot E1BQ32 395
organism: Bos taurus

Shp-2
type: Protein
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6SM70 67
type: UnificationXref
id: F6SM70
db: uniprot

Axin-2
type: ProteinReference
xref: uniprot O70240 1198
xref: PTHR46102:SF1
organism: Rattus norvegicus

RasGAP
type: Protein
entity reference: RasGAP
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0G2K6Q8 316
type: UnificationXref
id: A0A0G2K6Q8
db: uniprot

Ephrin type-B receptor 2
type: ProteinReference
xref: PTHR24416:SF123
xref: uniprot P28693 473
organism: Gallus gallus

Protein kinase C iota type
type: ProteinReference
xref: uniprot P41743 607
xref: PTHR24356:SF214
organism: Homo sapiens

STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_r291
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r291 1551
participant stoichiometry: PARTICIPANT STOICHIOMETRY r291 1550
left: Paxillin
interaction type: STATE_TRANSITION
right: Paxillin

Axin-1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot O70239 1197
organism: Rattus norvegicus

uniprot F1N871 633
type: UnificationXref
id: F1N871
db: uniprot

PARTICIPANT STOICHIOMETRY r181 1387
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r181 1388
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

APC2, WNT-signaling pathway regulator
type: ProteinReference
xref: PTHR12607:SF3
xref: uniprot A0A0G2JZW4 209
organism: Rattus norvegicus

uniprot Q08463 132
type: UnificationXref
id: Q08463
db: uniprot

PTHR22968:SF26
type: RelationshipXref
id: PTHR22968:SF26
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor 1
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot P61149 496
organism: Rattus norvegicus

EPH receptor B3
type: ProteinReference
xref: PTHR24416:SF120
xref: uniprot A0A2I3S8V9 458
organism: Pan troglodytes

Akt
type: ProteinReference
xref: P00223
standard name: Protein Kinase B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein Kinase B Synonym: Oncogene Akt,PKB,Rac serine/threonine kinase Accession: P00223
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Akt
member entity reference: Serine/threonine-protein kinase akt-2
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: V-akt murine thymoma viral oncogene homolog 2,-like
member entity reference: Serine/threonine-protein kinase akt-1
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC serine/threonine-protein kinase

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: uniprot F1PUX6 787
xref: PTHR24416:SF52
organism: Canis lupus familiaris

Neurogenic locus notch homolog protein 2
type: ProteinReference
xref: uniprot O35516 1261
xref: PTHR22804:SF52
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r206 1429
type: Stoichiometry
physical entity: PLD
stoichiometric coefficient: 1.0

Fibroblast growth factor 1
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot P61148 495
organism: Mus musculus

uniprot F1PNN6 726
type: UnificationXref
id: F1PNN6
db: uniprot

uniprot A0A0G2K5T3 879
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

uniprot F7HEW6 347
type: UnificationXref
id: F7HEW6
db: uniprot

PARTICIPANT STOICHIOMETRY r301 1424
type: Stoichiometry
physical entity: PIP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r206 1430
type: Stoichiometry
physical entity: PLD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r301 1423
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot P41156 107
type: UnificationXref
id: P41156
db: uniprot

uniprot E2RCV1 895
type: UnificationXref
id: E2RCV1
db: uniprot

PTHR22968:SF12
type: RelationshipXref
id: PTHR22968:SF12
db: PANTHER Family
relationship type: By Homology

uniprot F6XUZ7 343
type: UnificationXref
id: F6XUZ7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N871 633
organism: Gallus gallus

uniprot E2RNP2 562
type: UnificationXref
id: E2RNP2
db: uniprot

uniprot Q62159 1238
type: UnificationXref
id: Q62159
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__c_Fos-_c_Jun-RIGHT__Complex__c_Jun_c_Fos_-_r155
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r155 1489
participant stoichiometry: PARTICIPANT STOICHIOMETRY r155 1491
participant stoichiometry: PARTICIPANT STOICHIOMETRY r155 1490
left: c-Fos
left: c-Jun
interaction type: HETERODIMER_ASSOCIATION
right: Complex (c-Jun/c-Fos)

uniprot E2QSI0 1050
type: UnificationXref
id: E2QSI0
db: uniprot

uniprot O70534 740
type: UnificationXref
id: O70534
db: uniprot

Ephrin B2
type: ProteinReference
xref: uniprot B2B9A9 1028
xref: PTHR11304:SF18
organism: Rattus norvegicus

uniprot B2GUW1 969
type: UnificationXref
id: B2GUW1
db: uniprot

Frizzled-3
type: ProteinReference
xref: uniprot Q9NPG1 140
xref: PTHR11309:SF22
organism: Homo sapiens

Frizzled-related protein
type: ProteinReference
xref: PTHR11309:SF97
xref: uniprot F6RNC2 971
organism: Xenopus tropicalis

Signal transducer and activator of transcription 1-alpha/beta
type: ProteinReference
xref: uniprot P42224 536
xref: PTHR11801:SF18
organism: Homo sapiens

uniprot F7BTH1 789
type: UnificationXref
id: F7BTH1
db: uniprot

STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r261
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r261 1454
participant stoichiometry: PARTICIPANT STOICHIOMETRY r261 1455
left: FAK
interaction type: STATE_TRANSITION
right: FAK

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JAK1-RIGHT__JAK1-_r179
controller: Complex (EphR/Eph)

Angiopoietin-1
type: ProteinReference
xref: PTHR19143:SF156
xref: uniprot O08538 1140
organism: Mus musculus

uniprot P02489 818
type: UnificationXref
id: P02489
db: uniprot

Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q5FWK3 1122
xref: PTHR45808:SF6
organism: Mus musculus

Catenin beta-1
type: ProteinReference
xref: PTHR45976:SF4
xref: uniprot Q02248 93
organism: Mus musculus

uniprot Q99N69 207
type: UnificationXref
id: Q99N69
db: uniprot

Protein Wnt-2b
type: ProteinReference
xref: uniprot O70283 358
xref: PTHR12027:SF93
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2REH3 1155
xref: PTHR48015:SF20
organism: Canis lupus familiaris

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: PTHR24416:SF52
xref: uniprot P26618 794
organism: Mus musculus

uniprot F6WR53 50
type: UnificationXref
id: F6WR53
db: uniprot

uniprot P20352 152
type: UnificationXref
id: P20352
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q8UUX0 675
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r274 1402
type: Stoichiometry
physical entity: RasGAP
stoichiometric coefficient: 1.0

Ras guanine nucleotide exchange factor R
type: ProteinReference
xref: uniprot Q8SSQ0 184
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot F7EP57 916
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r276 1398
type: Stoichiometry
physical entity: HIF-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r274 1403
type: Stoichiometry
physical entity: RasGAP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r276 1399
type: Stoichiometry
physical entity: HIF-1
stoichiometric coefficient: 1.0

uniprot F6ZFF5 799
type: UnificationXref
id: F6ZFF5
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__FGFR_1-_FGF-RIGHT__Complex__FGFR_1_FGF_-_r202
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r202 1442
participant stoichiometry: PARTICIPANT STOICHIOMETRY r202 1443
participant stoichiometry: PARTICIPANT STOICHIOMETRY r202 1444
left: FGFR-1
left: FGF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (FGFR-1/FGF)

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P42227 531
organism: Mus musculus

Signal transducer and activator of transcription 1
type: ProteinReference
xref: uniprot P42225 537
xref: PTHR11801:SF18
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q8BTI9 962
xref: PTHR10048:SF33
organism: Mus musculus

uniprot P45985 244
type: UnificationXref
id: P45985
db: uniprot

uniprot H2Q104 1097
type: UnificationXref
id: H2Q104
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 1067
evidence: Evidence 1070
evidence: Evidence 1068
evidence: Evidence 1069
xref: uniprot E2REI6 1075
xref: PTHR44329:SF22
organism: Canis lupus familiaris

CSL
type: Protein
entity reference: CSL
feature: ACTIVE 25
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6ULE6 844
type: UnificationXref
id: F6ULE6
db: uniprot

Rho GTPase-activating protein 8
type: ProteinReference
xref: uniprot Q9CXP4 1125
organism: Mus musculus

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF87
xref: uniprot H2Q569 349
organism: Pan troglodytes

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot D3ZVF3 892
organism: Rattus norvegicus

uniprot Q95NE7 36
type: UnificationXref
id: Q95NE7
db: uniprot

Dishevelled segment polarity protein 3
type: ProteinReference
xref: PTHR10878:SF6
xref: uniprot F6TYA8 255
organism: Monodelphis domestica

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot A4D7S0 323
organism: Bos taurus

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F1PBB6 241
organism: Canis lupus familiaris

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P32871 943
organism: Bos taurus

Frizzled-5
type: ProteinReference
xref: uniprot Q13467 134
xref: PTHR11309:SF136
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot A0A3Q1LSY0 1151
organism: Bos taurus

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RWK1 1111
xref: PTHR45808:SF6
organism: Bos taurus

uniprot E2RJX4 655
type: UnificationXref
id: E2RJX4
db: uniprot

uniprot Q7ZVK8 299
type: UnificationXref
id: Q7ZVK8
db: uniprot

uniprot P01111 1007
type: UnificationXref
id: P01111
db: uniprot

uniprot F6RRK4 812
type: UnificationXref
id: F6RRK4
db: uniprot

V-crk avian sarcoma virus CT10 oncogene homolog-like
type: ProteinReference
xref: uniprot F6QIM7 398
organism: Xenopus tropicalis

uniprot H2QNG6 927
type: UnificationXref
id: H2QNG6
db: uniprot

uniprot Q63932 712
type: UnificationXref
id: Q63932
db: uniprot

uniprot Q90Z32 1042
type: UnificationXref
id: Q90Z32
db: uniprot

uniprot Q7PRL1 313
type: UnificationXref
id: Q7PRL1
db: uniprot

FGFR-1
type: Protein
entity reference: FGFR-1
feature: ACTIVE 25
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa12 1305
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P68404 610
type: UnificationXref
id: P68404
db: uniprot

uniprot O42825 1217
type: UnificationXref
id: O42825
db: uniprot

STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r290
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r290 1553
participant stoichiometry: PARTICIPANT STOICHIOMETRY r290 1552
left: FAK
interaction type: STATE_TRANSITION
right: FAK

uniprot E2RJA0 1156
type: UnificationXref
id: E2RJA0
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 328

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ATA8 813
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YCI3 170
organism: Monodelphis domestica

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P12841 876
organism: Rattus norvegicus

uniprot E2RB82 525
type: UnificationXref
id: E2RB82
db: uniprot

Protein Wnt-10a
type: ProteinReference
xref: uniprot Q9GZT5 389
xref: PTHR12027:SF89
organism: Homo sapiens

CSL
type: Protein
entity reference: CSL
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

MAP kinase-activated protein kinase 3
type: ProteinReference
xref: uniprot Q3UMW7 1104
xref: PTHR24349:SF64
organism: Mus musculus

uniprot H2QJA9 127
type: UnificationXref
id: H2QJA9
db: uniprot

Vascular endothelial growth factor A-A
type: ProteinReference
xref: uniprot O73682 1059
organism: Danio rerio

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

uniprot Q8NEB9 963
type: UnificationXref
id: Q8NEB9
db: uniprot

uniprot O00329 929
type: UnificationXref
id: O00329
db: uniprot

uniprot F6Y6B5 1114
type: UnificationXref
id: F6Y6B5
db: uniprot

PTHR24416:SF45
type: RelationshipXref
id: PTHR24416:SF45
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P14056 1085
organism: Rattus norvegicus

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot P02511 821
organism: Homo sapiens

uniprot W4Y0D3 97
type: UnificationXref
id: W4Y0D3
db: uniprot

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot P02510 820
organism: Bos taurus

Hypoxia inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor)
type: ProteinReference
xref: PTHR23043:SF7
xref: uniprot A0JND0 497
organism: Bos taurus

uniprot P22981 1014
type: UnificationXref
id: P22981
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F7BIC2 574
organism: Macaca mulatta

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 272

Alpha-crystallin A chain
type: ProteinReference
xref: uniprot P02504 819
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MTU2 1255
xref: PTHR24033:SF188
organism: Bos taurus

Vascular endothelial growth factor A
type: ProteinReference
xref: uniprot Q00731 1062
organism: Mus musculus

GTP-binding protein RHO1
type: ProteinReference
xref: uniprot Q9HF54 1250
organism: Ashbya gossypii

uniprot F7H0J3 1034
type: UnificationXref
id: F7H0J3
db: uniprot

uniprot P30558 160
type: UnificationXref
id: P30558
db: uniprot

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot F7HEW6 347
organism: Macaca mulatta

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05129 592
organism: Homo sapiens

Protein Wnt
type: ProteinReference
xref: uniprot Q5TP56 382
xref: PTHR12027:SF91
organism: Anopheles gambiae

GTPase NRas
type: ProteinReference
xref: uniprot P08556 1010
xref: PTHR24070:SF189
organism: Mus musculus

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05126 590
organism: Bos taurus

Ang 1 s226 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ang-1
stoichiometric coefficient: 1.0

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: uniprot P05128 591
xref: PTHR24356:SF162
organism: Bos taurus

Erk
type: Protein
entity reference: Erk
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7F6D5 1052
type: UnificationXref
id: F7F6D5
db: uniprot

uniprot H2Q383 925
type: UnificationXref
id: H2Q383
db: uniprot

uniprot Q99N57 1090
type: UnificationXref
id: Q99N57
db: uniprot

Phospholipase A2
type: ProteinReference
evidence: Evidence 766
xref: PTHR10728:SF13
xref: uniprot F7EEZ1 770
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re105 1479
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

Raf
type: Protein
entity reference: Raf
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q4JLT0 381
type: UnificationXref
id: Q4JLT0
db: uniprot

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 766
xref: PTHR10728:SF13
xref: uniprot P50393 778
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r245 1510
type: Stoichiometry
physical entity: JNKK1
stoichiometric coefficient: 1.0

Cytosolic phospholipase A2
type: ProteinReference
xref: PTHR10728:SF13
xref: uniprot P50392 777
organism: Danio rerio

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 601
organism: Mus musculus

Nuclear receptor subfamily 1 group I member 2
type: ProteinReference
xref: uniprot Q9R1A7 162
organism: Rattus norvegicus

Ras GTPase-activating protein 1
type: ProteinReference
xref: uniprot F1N7N8 143
xref: PTHR10194:SF19
organism: Bos taurus

uniprot P00528 56
type: UnificationXref
id: P00528
db: uniprot

uniprot Q28EW2 1020
type: UnificationXref
id: Q28EW2
db: uniprot

uniprot E2RL20 1076
type: UnificationXref
id: E2RL20
db: uniprot

uniprot Q13393 312
type: UnificationXref
id: Q13393
db: uniprot

PARTICIPANT STOICHIOMETRY r224 1347
type: Stoichiometry
physical entity: Shp-2
stoichiometric coefficient: 1.0

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P42930 827
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r224 1348
type: Stoichiometry
physical entity: Shp-2
stoichiometric coefficient: 1.0

Protein kinase C, brain isozyme
type: ProteinReference
xref: uniprot P05130 593
organism: Drosophila melanogaster

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot H2QKD0 1279
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r245 1509
type: Stoichiometry
physical entity: JNKK1
stoichiometric coefficient: 1.0

uniprot Q9QZK7 24
type: UnificationXref
id: Q9QZK7
db: uniprot

Ephrin B2
type: ProteinReference
xref: uniprot F1N0M5 1030
xref: PTHR11304:SF18
organism: Bos taurus

Axin-2
type: ProteinReference
xref: uniprot P57095 1201
xref: PTHR46102:SF1
organism: Danio rerio

uniprot Q62829 1174
type: UnificationXref
id: Q62829
db: uniprot

Axin-1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot P57094 1200
organism: Danio rerio

uniprot O15123 1132
type: UnificationXref
id: O15123
db: uniprot

uniprot P23298 602
type: UnificationXref
id: P23298
db: uniprot

uniprot P47197 670
type: UnificationXref
id: P47197
db: uniprot

uniprot P25054 215
type: UnificationXref
id: P25054
db: uniprot

Raf
type: ProteinReference
xref: P00243
standard name: Raf Oncogene
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Raf Oncogene Synonym: CRAF,Oncogene MIL,Raf,Transforming Replication-Defective Murine Retrovirus 3611-MSV,v-Raf-1 Murine Leukemia Viral Oncogene Homolog Accession: P00243
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Raf
member entity reference: B-Raf proto-oncogene, serine/threonine kinase
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: Raf homolog serine/threonine-protein kinase Raf
member entity reference: A-Raf proto-oncogene, serine/threonine kinase
member entity reference: Serine/threonine-protein kinase B-raf
member entity reference: Raf homolog serine/threonine-protein kinase
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase

uniprot F7GH85 346
type: UnificationXref
id: F7GH85
db: uniprot

uniprot Q9NP31 224
type: UnificationXref
id: Q9NP31
db: uniprot

Secreted frizzled-related protein 1
type: ProteinReference
xref: PTHR11309:SF87
xref: uniprot Q8N474 980
organism: Homo sapiens

uniprot F6XK08 212
type: UnificationXref
id: F6XK08
db: uniprot

Platelet-derived growth factor D
type: ProteinReference
xref: uniprot Q9GZP0 701
xref: PTHR11633:SF4
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r268 1440
type: Stoichiometry
physical entity: Grb14
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r268 1441
type: Stoichiometry
physical entity: Grb14
stoichiometric coefficient: 1.0

Protein C-ets-1
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot P14921 105
organism: Homo sapiens

STATE_TRANSITION_LEFT__PIP2-RIGHT__PIP3-_r301
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r301 1424
participant stoichiometry: PARTICIPANT STOICHIOMETRY r301 1423
left: PIP2
interaction type: STATE_TRANSITION
right: PIP3

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P52631 532
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r179 1404
type: Stoichiometry
physical entity: JAK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r179 1405
type: Stoichiometry
physical entity: JAK1
stoichiometric coefficient: 1.0

uniprot E1C021 1049
type: UnificationXref
id: E1C021
db: uniprot

uniprot P16333 515
type: UnificationXref
id: P16333
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot C3Z2P0 329
xref: PTHR12027:SF77
organism: Branchiostoma floridae

AGAP010940-PA (Fragment)
type: ProteinReference
xref: uniprot Q7QGY2 753
organism: Anopheles gambiae

uniprot Q62074 622
type: UnificationXref
id: Q62074
db: uniprot

PARTICIPANT STOICHIOMETRY re105 1480
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E1BIM8 48
xref: PTHR24418:SF53
organism: Bos taurus

C901
type: ProteinReference
xref: uniprot Q9VZ44 763
organism: Drosophila melanogaster

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7BYN4 527
xref: PTHR11801:SF2
organism: Monodelphis domestica

uniprot A0A3Q2U673 717
type: UnificationXref
id: A0A3Q2U673
db: uniprot

Ets
type: Protein
entity reference: Ets
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q6DHM9 1243
type: UnificationXref
id: Q6DHM9
db: uniprot

Ras guanine nucleotide exchange factor A
type: ProteinReference
xref: uniprot Q54PQ4 179
organism: Dictyostelium discoideum

uniprot Q3L254 380
type: UnificationXref
id: Q3L254
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F1N7C3 165
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: PTHR24351:SF182
xref: uniprot F1MDC9 565
organism: Bos taurus

uniprot O00548 738
type: UnificationXref
id: O00548
db: uniprot

uniprot A0A2J8LQ46 321
type: UnificationXref
id: A0A2J8LQ46
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24044:SF308
xref: uniprot F6TFV4 727
organism: Macaca mulatta

Phospholipase
type: ProteinReference
xref: PTHR18896:SF121
xref: uniprot F6VWY6 301
organism: Macaca mulatta

uniprot F1QGH7 86
type: UnificationXref
id: F1QGH7
db: uniprot

CRK proto-oncogene, adaptor protein
type: ProteinReference
xref: uniprot F7CN41 400
organism: Ornithorhynchus anatinus

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

uniprot Q66H76 203
type: UnificationXref
id: Q66H76
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 1067
evidence: Evidence 1070
evidence: Evidence 1068
evidence: Evidence 1069
xref: PTHR44329:SF22
xref: uniprot F7BRK5 1077
organism: Monodelphis domestica

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot P21552 363
organism: Mus musculus

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: uniprot Q7PVR1 298
organism: Anopheles gambiae

uniprot Q14449 230
type: UnificationXref
id: Q14449
db: uniprot

uniprot B2RYG7 7
type: UnificationXref
id: B2RYG7
db: uniprot

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: PTHR24416:SF52
xref: uniprot A0A3Q1ME99 785
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r186 1382
type: Stoichiometry
physical entity: Complex (Wnt/Fzd)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r186 1381
type: Stoichiometry
physical entity: Wnt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r186 1380
type: Stoichiometry
physical entity: Fzd
stoichiometric coefficient: 1.0

uniprot Q7QCP8 626
type: UnificationXref
id: Q7QCP8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot A0A3Q1MDX6 109
organism: Bos taurus

PTHR11243:SF22
type: RelationshipXref
id: PTHR11243:SF22
db: PANTHER Family
relationship type: By Homology

PTHR11243:SF25
type: RelationshipXref
id: PTHR11243:SF25
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QK27 519
type: UnificationXref
id: A0A1D5QK27
db: uniprot

uniprot Q66H84 1105
type: UnificationXref
id: Q66H84
db: uniprot

ncbitaxon 10116 8
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot F6QYV3 811
type: UnificationXref
id: F6QYV3
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TNY5 535
xref: PTHR11801:SF18
organism: Pan troglodytes

Caspase 9
type: ProteinReference
xref: P00216
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Caspase 9
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase 9 Synonym: APAF3,Apoptotic Protease Activating Factor 3 Accession: P00216
member entity reference: Uncharacterized protein
member entity reference: Caspase-9
member entity reference: CASP9 isoform 4
member entity reference: Caspase 9, isoform CRA_a

Growth factor receptor-bound protein 2
type: ProteinReference
evidence: Evidence 866
xref: uniprot Q6PC73 865
xref: PTHR46037:SF4
organism: Danio rerio

uniprot Q9Y243 678
type: UnificationXref
id: Q9Y243
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 993

MAP2K4 isoform 3
type: ProteinReference
xref: PTHR48013:SF20
xref: uniprot H2QCA7 243
organism: Pan troglodytes

uniprot F6TFV4 727
type: UnificationXref
id: F6TFV4
db: uniprot

uniprot Q94125 965
type: UnificationXref
id: Q94125
db: uniprot

Heat shock protein beta-2
type: ProteinReference
xref: uniprot Q99PR8 835
organism: Mus musculus

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: uniprot Q61194 953
xref: PTHR10048:SF28
organism: Mus musculus

MEKK1
type: ProteinReference
xref: P00208
standard name: Mitogen-activated protein kinase kinase kinase 1
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.MEKK1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen-Activated Kinase Kinase Kinase 1 Synonym: MAP/ERK Kinase Kinase 1,MAP3K1,MAPKKK1,MEK kinase Accession: P00208
member entity reference: Mitogen-activated protein kinase kinase kinase 1
member entity reference: Uncharacterized protein

uniprot F1MBU9 900
type: UnificationXref
id: F1MBU9
db: uniprot

uniprot P11345 1083
type: UnificationXref
id: P11345
db: uniprot

uniprot Q5FVG6 1121
type: UnificationXref
id: Q5FVG6
db: uniprot

uniprot F6ZKB3 646
type: UnificationXref
id: F6ZKB3
db: uniprot

uniprot Q9DEB8 388
type: UnificationXref
id: Q9DEB8
db: uniprot

uniprot A0A2I3TF56 100
type: UnificationXref
id: A0A2I3TF56
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot F7GH85 346
xref: PTHR12027:SF93
organism: Monodelphis domestica

Fibroblast growth factor 2
type: ProteinReference
xref: uniprot P15655 491
xref: PTHR11486:SF83
organism: Mus musculus

CRK like proto-oncogene, adaptor protein
type: ProteinReference
xref: uniprot E2RF98 396
xref: PTHR19969:SF20
organism: Canis lupus familiaris

Protein jagged-1
type: ProteinReference
xref: PTHR24044:SF448
xref: uniprot Q9QXX0 761
organism: Mus musculus

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR45807:SF5
xref: uniprot F1N0D6 75
organism: Bos taurus

Cytoplasmic protein NCK1
type: ProteinReference
xref: PTHR19969:SF16
xref: uniprot P16333 515
organism: Homo sapiens

uniprot F1NJX6 462
type: UnificationXref
id: F1NJX6
db: uniprot

uniprot Q16665 503
type: UnificationXref
id: Q16665
db: uniprot

uniprot F7ACT4 445
type: UnificationXref
id: F7ACT4
db: uniprot

Catenin beta-1
type: ProteinReference
xref: uniprot F1QGH7 86
xref: PTHR45976:SF4
organism: Danio rerio

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 878
xref: PTHR10048:SF107
organism: Rattus norvegicus

PTHR12607:SF3
type: RelationshipXref
id: PTHR12607:SF3
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Dsh-RIGHT__Dsh-_r188
controller: Complex (Wnt/Fzd)

STATE_TRANSITION_LEFT__JNK1-RIGHT__JNK1-_r246
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r246 1507
participant stoichiometry: PARTICIPANT STOICHIOMETRY r246 1508
left: JNK1
interaction type: STATE_TRANSITION
right: JNK1

PXN isoform 9
type: ProteinReference
xref: uniprot A0A2I3SDP5 187
xref: PTHR24216:SF11
organism: Pan troglodytes

uniprot F7EH19 286
type: UnificationXref
id: F7EH19
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RCM2 1178
xref: PTHR46957:SF2
organism: Macaca mulatta

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF448
xref: uniprot H2QJZ0 735
organism: Pan troglodytes

Uncharacterized protein rasG
type: ProteinReference
xref: uniprot F0ZWE6 998
organism: Dictyostelium purpureum

uniprot Q64143 956
type: UnificationXref
id: Q64143
db: uniprot

uniprot Q7QK91 1024
type: UnificationXref
id: Q7QK91
db: uniprot

uniprot O45818 588
type: UnificationXref
id: O45818
db: uniprot

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot P35465 1168
xref: PTHR48015:SF20
organism: Rattus norvegicus

uniprot F7F3Y7 1033
type: UnificationXref
id: F7F3Y7
db: uniprot

uniprot A0A3Q2TY19 643
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

uniprot Q8CIH5 1286
type: UnificationXref
id: Q8CIH5
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot P36507 708
organism: Homo sapiens

uniprot F7BYI4 575
type: UnificationXref
id: F7BYI4
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot P36506 707
organism: Rattus norvegicus

uniprot D4ADV8 250
type: UnificationXref
id: D4ADV8
db: uniprot

FRP
type: ProteinReference
xref: P00237
standard name: Frizzled-Related Protein
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.FRP
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Frizzled-Related Protein Synonym: Frzb,SARP,SFRP,Secreted Apoptosis-Related Protein,Secreted Frizzled-Related Protein Accession: P00237
member entity reference: Frizzled-3
member entity reference: Secreted frizzled-related protein 1
member entity reference: Secreted frizzled-related protein 3
member entity reference: Frizzled-1
member entity reference: Uncharacterized protein
member entity reference: FZD3 isoform 1
member entity reference: Frizzled-related protein
member entity reference: SFRP1 isoform 1
member entity reference: Sizzled
member entity reference: Frizzled class receptor 3
member entity reference: FZD1 protein
member entity reference: FRZB isoform 1

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7BYI4 575
organism: Macaca mulatta

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot F7GWI2 1164
type: UnificationXref
id: F7GWI2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Grb2-RIGHT__Grb2-_r272
controller: Complex (Tie2/Ang-1)

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 890
organism: Rattus norvegicus

Adenomatous polyposis coli protein
type: ProteinReference
xref: uniprot P25054 215
xref: PTHR12607:SF11
organism: Homo sapiens

uniprot Q5PU49 620
type: UnificationXref
id: Q5PU49
db: uniprot

uniprot P11362 69
type: UnificationXref
id: P11362
db: uniprot

Protein Wnt-7b
type: ProteinReference
xref: PTHR12027:SF73
xref: uniprot P56706 375
organism: Homo sapiens

Ephrin type-A receptor 3
type: ProteinReference
xref: uniprot F1NJX6 462
organism: Gallus gallus

uniprot Q9WUA6 676
type: UnificationXref
id: Q9WUA6
db: uniprot

STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r230
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r230 1543
participant stoichiometry: PARTICIPANT STOICHIOMETRY r230 1542
left: Ras
interaction type: STATE_TRANSITION
right: Ras

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Sck-RIGHT__Sck-_r287
controller: Complex (VEGFR-2/VEGF)

uniprot Q23130 1120
type: UnificationXref
id: Q23130
db: uniprot

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot P23928 825
organism: Rattus norvegicus

Uncharacterized protein rasS
type: ProteinReference
xref: uniprot F0ZVH9 997
organism: Dictyostelium purpureum

uniprot P83101 450
type: UnificationXref
id: P83101
db: uniprot

Alpha-crystallin B chain
type: ProteinReference
xref: uniprot P23927 824
organism: Mus musculus

uniprot P35465 1168
type: UnificationXref
id: P35465
db: uniprot

uniprot Q66IL5 517
type: UnificationXref
id: Q66IL5
db: uniprot

uniprot A0A3Q1LWJ8 642
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

Protein Wnt-2
type: ProteinReference
xref: uniprot P09544 361
xref: PTHR12027:SF86
organism: Homo sapiens

uniprot P09216 596
type: UnificationXref
id: P09216
db: uniprot

Protein Wnt-7a
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot P24383 367
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A3Q1MMD9 1273
xref: PTHR10336:SF25
organism: Bos taurus

Angiogenin-2
type: ProteinReference
xref: uniprot P80929 1135
xref: PTHR11437:SF54
organism: Bos taurus

uniprot F7G800 1163
type: UnificationXref
id: F7G800
db: uniprot

uniprot Q7Q5D3 60
type: UnificationXref
id: Q7Q5D3
db: uniprot

Catenin beta 1
type: ProteinReference
xref: uniprot F6WBD5 88
xref: PTHR45976:SF4
organism: Ornithorhynchus anatinus

Caspase 9
type: Protein
entity reference: Caspase 9
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q7PYV4 1202
type: UnificationXref
id: Q7PYV4
db: uniprot

Transcription factor 7-like 2
type: ProteinReference
xref: PTHR10373:SF32
xref: uniprot Q9NQB0 1065
organism: Homo sapiens

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot Q5M824 46
organism: Rattus norvegicus

uniprot H2QJZ0 735
type: UnificationXref
id: H2QJZ0
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__c_Fos-_c_Jun-RIGHT__Complex__c_Jun_c_Fos_-_r249
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r249 1502
participant stoichiometry: PARTICIPANT STOICHIOMETRY r249 1500
participant stoichiometry: PARTICIPANT STOICHIOMETRY r249 1501
left: c-Fos
left: c-Jun
interaction type: HETERODIMER_ASSOCIATION
right: Complex (c-Jun/c-Fos)

uniprot E2RHV6 506
type: UnificationXref
id: E2RHV6
db: uniprot

PARTICIPANT STOICHIOMETRY r289 1346
type: Stoichiometry
physical entity: Complex (VEGFR-2/VEGF)
stoichiometric coefficient: 1.0

uniprot F6Z5N3 1002
type: UnificationXref
id: F6Z5N3
db: uniprot

PARTICIPANT STOICHIOMETRY r289 1344
type: Stoichiometry
physical entity: VEGF
stoichiometric coefficient: 1.0

Delta-like protein
type: ProteinReference
xref: uniprot F7C1Q4 730
xref: PTHR24044:SF448
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r289 1345
type: Stoichiometry
physical entity: VEGFR-2
stoichiometric coefficient: 1.0

uniprot F1NG47 568
type: UnificationXref
id: F1NG47
db: uniprot

uniprot Q04721 1265
type: UnificationXref
id: Q04721
db: uniprot

Rho-related GTP-binding protein RhoA-D
type: ProteinReference
xref: uniprot Q6DHE8 1242
xref: PTHR24072:SF329
organism: Danio rerio

uniprot Q28GJ8 1234
type: UnificationXref
id: Q28GJ8
db: uniprot

uniprot F1NMD6 725
type: UnificationXref
id: F1NMD6
db: uniprot

Delta-like protein
type: ProteinReference
xref: uniprot I2CVK6 737
xref: PTHR24044:SF448
organism: Macaca mulatta

uniprot F1P4Q4 507
type: UnificationXref
id: F1P4Q4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QZ44 5
organism: Macaca mulatta

PTHR18896:SF57
type: RelationshipXref
id: PTHR18896:SF57
db: PANTHER Family
relationship type: By Homology

Rbpja protein
type: ProteinReference
xref: uniprot A4FTT3 841
xref: PTHR10665:SF3
organism: Danio rerio

Vascular endothelial growth factor A
type: ProteinReference
xref: uniprot P15692 1060
organism: Homo sapiens

uniprot F6SH04 122
type: UnificationXref
id: F6SH04
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot P53349 417
organism: Mus musculus

Suppressor of hairless homolog
type: ProteinReference
xref: uniprot O76808 849
organism: Ciona intestinalis

uniprot F1PZ54 499
type: UnificationXref
id: F1PZ54
db: uniprot

Glycogen synthase kinase 3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot F7ACT4 445
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot A0A3Q2TVV5 441
organism: Gallus gallus

Ang-1
type: Protein
entity reference: Ang-1
feature: ACTIVE 25
comment: SPECIES_TYPE=PROTEIN

Grb7
type: Protein
entity reference: Grb7
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Sphingosine kinase 1
type: ProteinReference
xref: PTHR12358:SF47
xref: uniprot Q9NYA1 804
organism: Homo sapiens

uniprot F7B727 193
type: UnificationXref
id: F7B727
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: uniprot P29353 42
xref: PTHR10337:SF2
organism: Homo sapiens

uniprot Q00731 1062
type: UnificationXref
id: Q00731
db: uniprot

Sex muscle abnormal protein 5
type: ProteinReference
xref: uniprot P29355 859
organism: Caenorhabditis elegans

uniprot F1MYM3 901
type: UnificationXref
id: F1MYM3
db: uniprot

eNOS s208 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: eNOS
stoichiometric coefficient: 1.0

uniprot B3DIG4 112
type: UnificationXref
id: B3DIG4
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TQ88 524
xref: PTHR11801:SF2
organism: Pan troglodytes

uniprot Q0IIE2 45
type: UnificationXref
id: Q0IIE2
db: uniprot

uniprot P19174 1283
type: UnificationXref
id: P19174
db: uniprot

STATE_TRANSITION_LEFT__JNKK1-RIGHT__JNKK1-_r245
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r245 1510
participant stoichiometry: PARTICIPANT STOICHIOMETRY r245 1509
left: JNKK1
interaction type: STATE_TRANSITION
right: JNKK1

Leupaxin
type: ProteinReference
xref: uniprot Q5M852 201
organism: Rattus norvegicus

Frizzled class receptor 2
type: ProteinReference
xref: uniprot H2QD74 126
xref: PTHR11309:SF34
organism: Pan troglodytes

uniprot F7EAT1 466
type: UnificationXref
id: F7EAT1
db: uniprot

STATE_TRANSITION_LEFT__c_Jun-RIGHT__c_Jun-_r154
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r154 1493
participant stoichiometry: PARTICIPANT STOICHIOMETRY r154 1492
left: c-Jun
interaction type: STATE_TRANSITION
right: c-Jun

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: uniprot Q1RMJ6 1232
xref: PTHR24072:SF100
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r250
controller: Complex (PDGFR/PDGF)

GTPase
type: Protein
entity reference: GTPase
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

RasGAP
type: ProteinReference
xref: P00190
standard name: Ras GTPase-Activating Protein
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.RasGAP
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras GTPase-Activating Protein Synonym: GAP,GTPase-Activating Protein,Guanosine Triphosphatase-Activating Protein,RAS p21 Protein Activator 1,RASA1 Accession: P00190
member entity reference: RAS p21 protein activator 1
member entity reference: Ras GTPase-activating protein 1
member entity reference: RAS p21 protein activator (GTPase activating protein) 1
member entity reference: Uncharacterized protein

uniprot Q22038 1233
type: UnificationXref
id: Q22038
db: uniprot

uniprot P42930 827
type: UnificationXref
id: P42930
db: uniprot

Delta-like protein 3
type: ProteinReference
xref: uniprot O88516 741
xref: PTHR24044:SF308
organism: Mus musculus

uniprot Q9PSX7 1252
type: UnificationXref
id: Q9PSX7
db: uniprot

Proline rich 5
type: ProteinReference
xref: uniprot H2QLV6 1116
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r290 1553
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r290 1552
type: Stoichiometry
physical entity: FAK
stoichiometric coefficient: 1.0

uniprot P34722 605
type: UnificationXref
id: P34722
db: uniprot

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot Q61036 1173
organism: Mus musculus

uniprot A8XIF5 1208
type: UnificationXref
id: A8XIF5
db: uniprot

Sck
type: ProteinReference
xref: P00202
standard name: Shc-like protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Shc-like protein Synonym: Shc Adaptor Homolog Accession: P00202
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Sck
member entity reference: SHC-transforming protein 2

uniprot Q9NL46 271
type: UnificationXref
id: Q9NL46
db: uniprot

Ephrin type-B receptor 3
type: ProteinReference
xref: uniprot P54754 478
xref: PTHR24416:SF120
organism: Mus musculus

Delta-like protein B
type: ProteinReference
xref: uniprot O57409 739
organism: Danio rerio

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6VAQ8 908
xref: PTHR10048:SF7
organism: Ornithorhynchus anatinus

uniprot O77628 873
type: UnificationXref
id: O77628
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A2I3T7A8 884
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r275 1401
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r275 1400
type: Stoichiometry
physical entity: Ets
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SOS_1-RIGHT__SOS_1-_r226
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r226 1340
participant stoichiometry: PARTICIPANT STOICHIOMETRY r226 1341
left: SOS-1
interaction type: STATE_TRANSITION
right: SOS-1

Axin-1
type: ProteinReference
xref: PTHR46102:SF3
xref: uniprot O15169 1195
organism: Homo sapiens

JAK1
type: ProteinReference
xref: P00185
standard name: Janus Kinase 1
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.JAK1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Janus Kinase 1 Synonym: Synonym not specified Accession: P00185
member entity reference: Tyrosine-protein kinase JAK1
member entity reference: Tyrosine-protein kinase

uniprot B8JIQ1 442
type: UnificationXref
id: B8JIQ1
db: uniprot

uniprot F6SRK5 87
type: UnificationXref
id: F6SRK5
db: uniprot

Ephrin type-B receptor 2
type: ProteinReference
xref: PTHR24416:SF123
xref: uniprot P54763 480
organism: Mus musculus

Ephrin type-B receptor 1
type: ProteinReference
xref: uniprot P54762 479
organism: Homo sapiens

Ephrin type-B receptor 2
type: ProteinReference
xref: PTHR24416:SF123
xref: uniprot P29323 476
organism: Homo sapiens

Ephrin type-A receptor 3
type: ProteinReference
xref: uniprot P29320 475
organism: Homo sapiens

Segment polarity protein dishevelled homolog DVL-3
type: ProteinReference
xref: uniprot Q61062 269
xref: PTHR10878:SF6
organism: Mus musculus

Adapter molecule crk
type: ProteinReference
xref: PTHR19969:SF8
xref: uniprot Q64010 409
organism: Mus musculus

uniprot P68280 828
type: UnificationXref
id: P68280
db: uniprot

Cytoplasmic protein
type: ProteinReference
xref: PTHR19969:SF12
xref: uniprot F7D094 509
organism: Macaca mulatta

EPH receptor B3
type: ProteinReference
xref: uniprot F1P9P1 463
xref: PTHR24416:SF120
organism: Canis lupus familiaris

uniprot P31266 851
type: UnificationXref
id: P31266
db: uniprot

Fibroblast growth factor receptor
type: ProteinReference
xref: PTHR24416:SF131
xref: uniprot A0A1D5R2V9 63
organism: Macaca mulatta

uniprot P63085 294
type: UnificationXref
id: P63085
db: uniprot

uniprot Q9HE04 1249
type: UnificationXref
id: Q9HE04
db: uniprot

uniprot M0R9D3 354
type: UnificationXref
id: M0R9D3
db: uniprot

Ephrin type-B receptor 3
type: ProteinReference
xref: PTHR24416:SF120
xref: uniprot P54753 477
organism: Homo sapiens

uniprot F7EPN2 145
type: UnificationXref
id: F7EPN2
db: uniprot

uniprot Q61483 750
type: UnificationXref
id: Q61483
db: uniprot

uniprot O93599 529
type: UnificationXref
id: O93599
db: uniprot

Nitric oxide synthase, endothelial
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot Q62600 438
organism: Rattus norvegicus

Dishevelled segment polarity protein 3
type: ProteinReference
xref: uniprot F1MMW6 253
xref: PTHR10878:SF6
organism: Bos taurus

PDGFB isoform 1
type: ProteinReference
xref: uniprot H2QLQ2 690
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r226 1341
type: Stoichiometry
physical entity: SOS-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r226 1340
type: Stoichiometry
physical entity: SOS-1
stoichiometric coefficient: 1.0

uniprot O88516 741
type: UnificationXref
id: O88516
db: uniprot

uniprot P91634 952
type: UnificationXref
id: P91634
db: uniprot

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

uniprot O70167 936
type: UnificationXref
id: O70167
db: uniprot

uniprot F1PUX6 787
type: UnificationXref
id: F1PUX6
db: uniprot

Ephrin type-A receptor 3
type: ProteinReference
xref: uniprot P29319 474
organism: Mus musculus

uniprot O08538 1140
type: UnificationXref
id: O08538
db: uniprot

uniprot P26450 941
type: UnificationXref
id: P26450
db: uniprot

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot A0A3Q1LUE0 65
xref: PTHR24416:SF131
organism: Bos taurus

Fibroblast growth factor receptor 1
type: ProteinReference
xref: uniprot Q04589 72
xref: PTHR24416:SF131
organism: Rattus norvegicus

STAT1
type: Protein
entity reference: STAT1
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P16054 599
type: UnificationXref
id: P16054
db: uniprot

uniprot A0A1D5R803 319
type: UnificationXref
id: A0A1D5R803
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31751 668
organism: Homo sapiens

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31750 667
xref: PTHR24356:SF171
organism: Mus musculus

uniprot P05627 543
type: UnificationXref
id: P05627
db: uniprot

eco ECO:0000270 356
type: UnificationXref
id: ECO:0000270
db: eco

Bos taurus
type: BioSource
xref: ncbitaxon 9913 27

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F1N8W8 1157
organism: Gallus gallus

PTHR11437:SF54
type: RelationshipXref
id: PTHR11437:SF54
db: PANTHER Family
relationship type: By Homology

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: uniprot P49138 1101
xref: PTHR24349:SF63
organism: Mus musculus

MAP kinase-activated protein kinase 2
type: ProteinReference
xref: PTHR24349:SF63
xref: uniprot P49137 1100
organism: Homo sapiens

Axin-2
type: ProteinReference
xref: uniprot O88566 1199
xref: PTHR46102:SF1
organism: Mus musculus

uniprot Q99M51 518
type: UnificationXref
id: Q99M51
db: uniprot

uniprot P49023 196
type: UnificationXref
id: P49023
db: uniprot

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 387

uniprot P04426 359
type: UnificationXref
id: P04426
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31749 666
xref: PTHR24356:SF171
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re108 1467
type: Stoichiometry
physical entity: Caspase 9
stoichiometric coefficient: 1.0

uniprot Q63788 954
type: UnificationXref
id: Q63788
db: uniprot

PARTICIPANT STOICHIOMETRY re108 1468
type: Stoichiometry
physical entity: Caspase 9
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Ca2_PLUS_-_eNOS-RIGHT__Complex__eNOS_Ca2_PLUS_-_r256
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r256 1466
participant stoichiometry: PARTICIPANT STOICHIOMETRY r256 1464
participant stoichiometry: PARTICIPANT STOICHIOMETRY r256 1465
left: Ca2+
left: eNOS
interaction type: STATE_TRANSITION
right: Complex (eNOS/Ca2+

uniprot F7HC75 580
type: UnificationXref
id: F7HC75
db: uniprot

uniprot Q0V8L6 311
type: UnificationXref
id: Q0V8L6
db: uniprot

uniprot P56706 375
type: UnificationXref
id: P56706
db: uniprot

EPH-related receptor tyrosine kinase ligand 2
type: ProteinReference
xref: uniprot F7H0J3 1034
organism: Macaca mulatta

uniprot A0A0R4IAF3 713
type: UnificationXref
id: A0A0R4IAF3
db: uniprot

uniprot Q61315 217
type: UnificationXref
id: Q61315
db: uniprot

PARTICIPANT STOICHIOMETRY r284 1367
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

Cytosolic phospholipase A2
type: ProteinReference
xref: PTHR10728:SF13
xref: uniprot P49147 776
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r284 1366
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r284 1365
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: uniprot P51141 263
xref: PTHR10878:SF5
organism: Mus musculus

Tissue factor
type: ProteinReference
xref: PTHR20859:SF22
xref: uniprot P20352 152
organism: Mus musculus

Segment polarity protein dishevelled
type: ProteinReference
xref: uniprot P51140 262
organism: Drosophila melanogaster

Platelet-derived growth factor C
type: ProteinReference
xref: uniprot Q9EQX6 700
organism: Rattus norvegicus

uniprot Q07494 481
type: UnificationXref
id: Q07494
db: uniprot

uniprot P54754 478
type: UnificationXref
id: P54754
db: uniprot

uniprot P50904 148
type: UnificationXref
id: P50904
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P08487 1280
organism: Bos taurus

Glycogen synthase kinase-3
type: ProteinReference
xref: uniprot P51136 449
organism: Dictyostelium discoideum

PTHR24356:SF214
type: RelationshipXref
id: PTHR24356:SF214
db: PANTHER Family
relationship type: By Homology

Protein Wnt
type: ProteinReference
xref: uniprot F1MEW8 336
xref: PTHR12027:SF89
organism: Bos taurus

Rho-related GTP-binding protein RhoA-B
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q6DHM9 1243
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SRK5 87
xref: PTHR45976:SF4
organism: Monodelphis domestica

uniprot P52631 532
type: UnificationXref
id: P52631
db: uniprot

uniprot A0A1D5RCM2 1178
type: UnificationXref
id: A0A1D5RCM2
db: uniprot

uniprot Q05513 615
type: UnificationXref
id: Q05513
db: uniprot

uniprot F1NHI6 970
type: UnificationXref
id: F1NHI6
db: uniprot

Segment polarity protein dishevelled homolog DVL-1
type: ProteinReference
xref: uniprot Q5IS48 267
xref: PTHR10878:SF5
organism: Pan troglodytes

uniprot Q07008 1266
type: UnificationXref
id: Q07008
db: uniprot

RAC serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q8INB9 674
organism: Drosophila melanogaster

uniprot Q90WK2 698
type: UnificationXref
id: Q90WK2
db: uniprot

beta catenin
type: Protein
entity reference: beta catenin
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot H2QAS6 583
type: UnificationXref
id: H2QAS6
db: uniprot

uniprot F1MDC9 565
type: UnificationXref
id: F1MDC9
db: uniprot

uniprot H2QLV6 1116
type: UnificationXref
id: H2QLV6
db: uniprot

uniprot O35625 1196
type: UnificationXref
id: O35625
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 55

Uncharacterized protein
type: ProteinReference
xref: uniprot E9HL06 1212
organism: Daphnia pulex

Nck
type: Protein
entity reference: Nck
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7A632 573
type: UnificationXref
id: F7A632
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Crk-RIGHT__Crk-_r221
controller: Complex (FGFR-1/FGF)

uniprot Q04759 614
type: UnificationXref
id: Q04759
db: uniprot

uniprot P01112 1008
type: UnificationXref
id: P01112
db: uniprot

Delta-like protein 3
type: ProteinReference
xref: uniprot Q9NYJ7 760
xref: PTHR24044:SF308
organism: Homo sapiens

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q5PU49 620
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QEP8 1254
xref: PTHR24033:SF188
organism: Macaca mulatta

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot H9FU32 1078
organism: Macaca mulatta

SOS-1
type: Protein
entity reference: SOS-1
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6PMQ6 338
type: UnificationXref
id: F6PMQ6
db: uniprot

PAR
type: Protein
entity reference: PAR
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q6CAP4 1241
type: UnificationXref
id: Q6CAP4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38MAPK-RIGHT__p38MAPK-_r294
controller: Complex (VEGFR-2/VEGF)

Armadillo segment polarity protein
type: ProteinReference
xref: uniprot P18824 91
organism: Drosophila melanogaster

uniprot F7E9T7 401
type: UnificationXref
id: F7E9T7
db: uniprot

Evidence 1070
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

VRAP
type: ProteinReference
xref: P00196
standard name: VEGFR-Associated Protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: VEGFR-Associated Protein Synonym: SH2 Domain Protein 2A,SH2D2A,T-Cell SH2 Domain Containing Adaptor Protein,TSAD,VRAP Accession: P00196
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.VRAP
member entity reference: SH2 domain-containing protein 2A
member entity reference: Uncharacterized protein
member entity reference: SH2 domain containing 2A

PLC-gamma
type: Protein
entity reference: PLC-gamma
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Ras-RIGHT__Ras-_r281
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r281 1377
participant stoichiometry: PARTICIPANT STOICHIOMETRY r281 1376
left: Ras
interaction type: STATE_TRANSITION
right: Ras

uniprot Q9WVB9 273
type: UnificationXref
id: Q9WVB9
db: uniprot

JNK1
type: Protein
entity reference: JNK1
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q02384 176
organism: Mus musculus

STATE_TRANSITION_LEFT__Ca2_PLUS_-_eNOS-RIGHT__Complex__eNOS_Ca2_PLUS_-_r295
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r295 1540
participant stoichiometry: PARTICIPANT STOICHIOMETRY r295 1541
participant stoichiometry: PARTICIPANT STOICHIOMETRY r295 1539
left: Ca2+
left: eNOS
interaction type: STATE_TRANSITION
right: Complex (eNOS/Ca2+

uniprot Q18239 264
type: UnificationXref
id: Q18239
db: uniprot

uniprot P47196 669
type: UnificationXref
id: P47196
db: uniprot

uniprot Q07292 1089
type: UnificationXref
id: Q07292
db: uniprot

VEGF
type: Protein
entity reference: VEGF
comment: SPECIES_TYPE=PROTEIN

uniprot P49071 1099
type: UnificationXref
id: P49071
db: uniprot

Rho GTPase-activating protein 1
type: ProteinReference
xref: PTHR45808:SF6
xref: uniprot D4A6C5 1110
organism: Rattus norvegicus

Evidence 1069
type: Evidence
evidence code: ISS
comment: SPACC P11345

Evidence 1067
type: Evidence
evidence code: ISS
comment: SPACC P04049

Protein kinase C
type: ProteinReference
xref: uniprot E1BQN6 557
xref: PTHR24356:SF170
organism: Gallus gallus

Jun proto-oncogene
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot F6RYL1 540
organism: Xenopus tropicalis

Evidence 1068
type: Evidence
evidence code: ISS
comment: SPACC P05625

uniprot G3V9W2 79
type: UnificationXref
id: G3V9W2
db: uniprot

uniprot X1WEJ5 394
type: UnificationXref
id: X1WEJ5
db: uniprot

uniprot A0A2I3RQJ8 548
type: UnificationXref
id: A0A2I3RQJ8
db: uniprot

uniprot H2QML4 1216
type: UnificationXref
id: H2QML4
db: uniprot

uniprot A8WR64 553
type: UnificationXref
id: A8WR64
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6VXG1 909
xref: PTHR10048:SF107
organism: Xenopus tropicalis

Frizzled class receptor 8b
type: ProteinReference
xref: uniprot B0S6S2 111
xref: PTHR11309:SF140
organism: Danio rerio

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 774
xref: PTHR10728:SF13
xref: uniprot P47712 773
organism: Homo sapiens

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 766
xref: PTHR10728:SF13
xref: uniprot P47713 775
organism: Mus musculus

Paxillin
type: ProteinReference
xref: PTHR24216:SF11
xref: uniprot F7B727 193
organism: Xenopus tropicalis

APC s28 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

uniprot A5D7R9 987
type: UnificationXref
id: A5D7R9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf-RIGHT__Raf-_r231
controller: Ras

PARTICIPANT STOICHIOMETRY r156 1486
type: Stoichiometry
physical entity: GTPase
stoichiometric coefficient: 1.0

GTPase NRas
type: ProteinReference
xref: uniprot P01111 1007
xref: PTHR24070:SF189
organism: Homo sapiens

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot P01112 1008
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r156 1485
type: Stoichiometry
physical entity: GTPase
stoichiometric coefficient: 1.0

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P28867 604
organism: Mus musculus

PTHR24418:SF78
type: RelationshipXref
id: PTHR24418:SF78
db: PANTHER Family
relationship type: By Homology

RBPJL isoform 1
type: ProteinReference
xref: uniprot A0A2J8MK73 838
organism: Pan troglodytes

uniprot H2QY65 1259
type: UnificationXref
id: H2QY65
db: uniprot

PTHR10665:SF2
type: RelationshipXref
id: PTHR10665:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10665:SF3
type: RelationshipXref
id: PTHR10665:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q9NR61 759
type: UnificationXref
id: Q9NR61
db: uniprot

uniprot A0A2I3SIY1 883
type: UnificationXref
id: A0A2I3SIY1
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot A0A1D5QFE1 318
xref: PTHR12027:SF93
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot E2RLH2 1211
organism: Canis lupus familiaris

AGAP009499-PA
type: ProteinReference
xref: uniprot Q7QG48 411
organism: Anopheles gambiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r279
controller: Raf

uniprot P23726 939
type: UnificationXref
id: P23726
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P01101 875
xref: PTHR23351:SF4
organism: Mus musculus

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: uniprot P12931 59
xref: PTHR24418:SF53
organism: Homo sapiens

Delta-like protein A
type: ProteinReference
xref: uniprot Q6DI48 752
organism: Danio rerio

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P01100 874
organism: Homo sapiens

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q91Y86 650
xref: PTHR24055:SF222
organism: Mus musculus

uniprot Q9NYJ7 760
type: UnificationXref
id: Q9NYJ7
db: uniprot

uniprot Q7PMF0 960
type: UnificationXref
id: Q7PMF0
db: uniprot

uniprot F7GTQ2 578
type: UnificationXref
id: F7GTQ2
db: uniprot

uniprot A8X0X5 990
type: UnificationXref
id: A8X0X5
db: uniprot

uniprot P80929 1135
type: UnificationXref
id: P80929
db: uniprot

STAT1
type: Protein
entity reference: STAT1
feature: ACTIVE 25
cellular location: nuclear membrane
comment: SPECIES_TYPE=PROTEIN

Dsh
type: ProteinReference
xref: P00200
standard name: Dishelvelled
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Dishelvelled Synonym: Dvl Accession: P00200
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Dsh
member entity reference: dishevelled homolog
member entity reference: Segment polarity protein dishevelled homolog DVL-3
member entity reference: Uncharacterized protein
member entity reference: Dishevelled segment polarity protein 3
member entity reference: Dishevelled segment polarity protein 2
member entity reference: Dishevelled segment polarity protein 1
member entity reference: Segment polarity protein dishevelled homolog DVL-2
member entity reference: Segment polarity protein dishevelled homolog DVL-1
member entity reference: Segment polarity protein dishevelled
member entity reference: DiSHevelled related
member entity reference: Dishevelled segment polarity protein 3a
member entity reference: DVL3 isoform 1
member entity reference: DVL2 isoform 1
member entity reference: Segment polarity protein dishevelled homolog mig-5

STATE_TRANSITION_LEFT__MEKK1-RIGHT__MEKK1-_r151
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r151 1498
participant stoichiometry: PARTICIPANT STOICHIOMETRY r151 1499
left: MEKK1
interaction type: STATE_TRANSITION
right: MEKK1

STATE_TRANSITION_LEFT__VRAP-RIGHT__VRAP-_r286
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r286 1358
participant stoichiometry: PARTICIPANT STOICHIOMETRY r286 1357
left: VRAP
interaction type: STATE_TRANSITION
right: VRAP

ncbitaxon 9913 27
type: UnificationXref
id: 9913
db: ncbitaxon

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 1210

Angiopoietin-2
type: ProteinReference
xref: uniprot O35462 1133
organism: Rattus norvegicus

Coagulation factor VII
type: ProteinReference
xref: PTHR24278:SF26
xref: uniprot P22457 276
organism: Bos taurus

PTHR24072:SF329
type: RelationshipXref
id: PTHR24072:SF329
db: PANTHER Family
relationship type: By Homology

MAP kinase-activated protein kinase mak-2
type: ProteinReference
xref: uniprot Q965G5 1107
organism: Caenorhabditis elegans

Adenomatous polyposis coli protein 2
type: ProteinReference
xref: PTHR12607:SF3
xref: uniprot O95996 214
organism: Homo sapiens

uniprot H2R2U1 90
type: UnificationXref
id: H2R2U1
db: uniprot

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q9PSX7 1252
organism: Gallus gallus

uniprot P46109 404
type: UnificationXref
id: P46109
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Shp_2-RIGHT__Shp_2-_r224
controller: FRS-2

PDGFD isoform 1
type: ProteinReference
xref: PTHR11633:SF4
xref: uniprot A0A2I3SLM0 679
organism: Pan troglodytes

Delta-like protein 4
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot Q9NR61 759
organism: Homo sapiens

GTP-binding protein rho5
type: ProteinReference
xref: uniprot Q9HE04 1249
organism: Schizosaccharomyces pombe

Crk
type: Protein
entity reference: Crk
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot E9HL06 1212
type: UnificationXref
id: E9HL06
db: uniprot

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

Recombination signal binding protein for immunoglobulin kappa J region
type: ProteinReference
xref: uniprot E2QV83 843
xref: PTHR10665:SF3
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__Ca2_PLUS_-_cPLA2-RIGHT__Complex__cPLA2_endsub_Ca2_PLUS__endsuper_-_r277
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r277 1397
participant stoichiometry: PARTICIPANT STOICHIOMETRY r277 1395
participant stoichiometry: PARTICIPANT STOICHIOMETRY r277 1396
left: Ca2+
left: cPLA2
interaction type: STATE_TRANSITION
right: Complex (cPLA2_endsub/Ca2+_endsuper)

uniprot Q9YH60 454
type: UnificationXref
id: Q9YH60
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 1231

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 1251

uniprot Q9PUJ4 1043
type: UnificationXref
id: Q9PUJ4
db: uniprot

uniprot Q95117 982
type: UnificationXref
id: Q95117
db: uniprot

HSP27
type: Protein
entity reference: HSP27
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P26450 941
organism: Mus musculus

HRAS isoform 2
type: ProteinReference
xref: uniprot K7ALD7 1006
xref: PTHR24070:SF385
organism: Pan troglodytes

Protein CBR-CWN-2
type: ProteinReference
xref: PTHR12027:SF77
xref: uniprot A8WV10 325
organism: Caenorhabditis briggsae

uniprot A0A3Q1MDX6 109
type: UnificationXref
id: A0A3Q1MDX6
db: uniprot

GRB2
type: Protein
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

RAS p21 protein activator 1
type: ProteinReference
xref: uniprot F7EPN2 145
xref: PTHR10194:SF19
organism: Ornithorhynchus anatinus

uniprot F6XP81 663
type: UnificationXref
id: F6XP81
db: uniprot

Delta-like protein
type: ProteinReference
xref: uniprot A4IHM4 718
organism: Xenopus tropicalis

uniprot F7BYN4 527
type: UnificationXref
id: F7BYN4
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F1MX38 526
xref: PTHR11801:SF2
organism: Bos taurus

uniprot A0A1D5PXC6 641
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

Phospholipase D1
type: ProteinReference
xref: uniprot Q13393 312
xref: PTHR18896:SF57
organism: Homo sapiens

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

Hypoxia-inducible factor 1-alpha
type: ProteinReference
xref: uniprot F1NJK2 498
organism: Gallus gallus

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF320
xref: uniprot F7G756 733
organism: Macaca mulatta

PTHR24418:SF53
type: RelationshipXref
id: PTHR24418:SF53
db: PANTHER Family
relationship type: By Homology

uniprot F6Y8U0 1192
type: UnificationXref
id: F6Y8U0
db: uniprot

uniprot A0A2I3S8V9 458
type: UnificationXref
id: A0A2I3S8V9
db: uniprot

Protein Wnt
type: ProteinReference
xref: uniprot H2RAM0 351
xref: PTHR12027:SF93
organism: Pan troglodytes

PAR s222 a8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PAR
stoichiometric coefficient: 1.0

uniprot F7H8I5 1258
type: UnificationXref
id: F7H8I5
db: uniprot

uniprot O14641 261
type: UnificationXref
id: O14641
db: uniprot

ncbitaxon 284812 1231
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot E2QY91 251
type: UnificationXref
id: E2QY91
db: uniprot

FGFR 1 s30 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FGFR-1
stoichiometric coefficient: 1.0

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 98

Uncharacterized protein
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot F6PWM3 117
organism: Monodelphis domestica

uniprot F7DJK6 1051
type: UnificationXref
id: F7DJK6
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot H2R5K3 416
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r261
controller: PI3K

uniprot F6QIM7 398
type: UnificationXref
id: F6QIM7
db: uniprot

Platelet-derived growth factor subunit B
type: ProteinReference
xref: uniprot P01127 691
organism: Homo sapiens

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: PTHR21258:SF40
xref: uniprot E1B7I9 1048
organism: Bos taurus

uniprot P62745 1227
type: UnificationXref
id: P62745
db: uniprot

uniprot E2QVP7 113
type: UnificationXref
id: E2QVP7
db: uniprot

EphR
type: ProteinReference
xref: P00212
standard name: Ephrin Receptor
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.RECEPTOR.EphR
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: EPH receptor B3
member entity reference: Ephrin type-A receptor 3
member entity reference: EPH receptor B2
member entity reference: Ephrin type-B receptor 3
member entity reference: Ephrin type-B receptor 2
member entity reference: Ephrin type-B receptor 1
member entity reference: Eph receptor B3
member entity reference: Eph receptor B2
member entity reference: Uncharacterized protein
member entity reference: Ephrin type-B receptor 1 (Fragment)
member entity reference: Ephrin type-B receptor 3 (Fragment)
member entity reference: Eph receptor B3a
member entity reference: EPH receptor A3

PARTICIPANT STOICHIOMETRY r272 1408
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r272 1409
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

Raf homolog serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q07292 1089
organism: Caenorhabditis elegans

uniprot P18537 131
type: UnificationXref
id: P18537
db: uniprot

Protein Wnt-5b
type: ProteinReference
xref: uniprot Q92050 385
xref: PTHR12027:SF87
organism: Danio rerio

Delta/Serrate
type: Protein
entity reference: Delta/Serrate
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa2 1317
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__RasGAP-RIGHT__RasGAP-_r274
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r274 1402
participant stoichiometry: PARTICIPANT STOICHIOMETRY r274 1403
left: RasGAP
interaction type: STATE_TRANSITION
right: RasGAP

Delta-like protein
type: ProteinReference
xref: uniprot A0A0R4IAF3 713
xref: PTHR24049:SF18
organism: Danio rerio

uniprot F6YB95 845
type: UnificationXref
id: F6YB95
db: uniprot

FRS3 isoform 1
type: ProteinReference
xref: uniprot H2QSZ7 1053
organism: Pan troglodytes

uniprot F7EP57 916
type: UnificationXref
id: F7EP57
db: uniprot

uniprot Q6J1J1 236
type: UnificationXref
id: Q6J1J1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot A0A3Q1LTT9 26
organism: Bos taurus

Secreted frizzled-related protein 1
type: ProteinReference
xref: PTHR11309:SF87
xref: uniprot Q8C4U3 979
organism: Mus musculus

uniprot B3DM35 102
type: UnificationXref
id: B3DM35
db: uniprot

uniprot Q9JIP6 139
type: UnificationXref
id: Q9JIP6
db: uniprot

Angiopoietin 2
type: ProteinReference
xref: PTHR19143:SF199
xref: uniprot F6VG66 1129
organism: Ornithorhynchus anatinus

Phospholipase
type: ProteinReference
xref: uniprot A8WUL4 300
organism: Caenorhabditis briggsae

Protein Wnt-2
type: ProteinReference
xref: PTHR12027:SF86
xref: uniprot Q92048 384
organism: Danio rerio

uniprot P54762 479
type: UnificationXref
id: P54762
db: uniprot

Frizzled-3
type: ProteinReference
xref: PTHR11309:SF22
xref: uniprot Q61086 136
organism: Mus musculus

EphR
type: Protein
entity reference: EphR
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Eph
type: Protein
entity reference: Eph
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa6 1333
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7HLC7 921
type: UnificationXref
id: F7HLC7
db: uniprot

Kinase insert domain receptor
type: ProteinReference
xref: uniprot F1MWF1 632
xref: PTHR24416:SF45
organism: Bos taurus

Fibroblast growth factor 1
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot P05230 489
organism: Homo sapiens

uniprot P27577 106
type: UnificationXref
id: P27577
db: uniprot

uniprot Q5M824 46
type: UnificationXref
id: Q5M824
db: uniprot

Protein tyrosine kinase 2
type: ProteinReference
xref: uniprot F7CW18 426
xref: PTHR24418:SF78
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK-RIGHT__FAK-_r261
controller: Grb7

uniprot Q9PUR2 836
type: UnificationXref
id: Q9PUR2
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 989

Pak
type: Protein
entity reference: Pak
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Cytoplasmic protein
type: ProteinReference
xref: uniprot Q66IL5 517
xref: PTHR19969:SF16
organism: Xenopus tropicalis

GRB2-related adapter protein
type: ProteinReference
xref: uniprot A6QLK6 856
organism: Bos taurus

Angiopoietin 2
type: ProteinReference
xref: uniprot Q1LWR7 1136
organism: Danio rerio

uniprot P79737 1018
type: UnificationXref
id: P79737
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11849:SF209
xref: uniprot F6Y1Z2 103
organism: Monodelphis domestica

JNKK1
type: ProteinReference
xref: P00199
standard name: c-Jun N-terminal Kinase Kinase 1
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.JNKK1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: c-Jun N-terminal Kinase Kinase 1 Synonym: MAP2K4,MAPK/ERK Kinase 4,MAPKK4,MEK4,MKK4,Mitogen-Activated Protein Kinase Kinase 4,PRKMK4,Protein Kinase, Mitogen-Activated, Kinase 4,SAPK/ERK Kinase 1,SEK1,SERK1 Accession: P00199
member entity reference: MAP2K4 isoform 3
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: MAP2K4 protein
member entity reference: Mitogen-activated protein kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase 4A
member entity reference: Uncharacterized protein

uniprot H2QGQ4 1184
type: UnificationXref
id: H2QGQ4
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QLB4 289
xref: PTHR24055:SF203
organism: Pan troglodytes

uniprot F7BWZ1 974
type: UnificationXref
id: F7BWZ1
db: uniprot

AGAP012252-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q042 625
organism: Anopheles gambiae

Rac
type: ProteinReference
xref: P00245
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Rho GTPase Synonym: CDC42,Cell Division Cycle 42 Accession: P00245
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Rac
member entity reference: Proline-rich protein 5
member entity reference: Rho GTPase-activating protein 8
member entity reference: Rho GTPase-activating protein 1
member entity reference: ARHGAP1 isoform 3
member entity reference: Uncharacterized protein
member entity reference: Rho GTPase Activating protein
member entity reference: Cdc42 GTPase-activating protein
member entity reference: Rho GTPase activating protein 1
member entity reference: Proline rich 5
member entity reference: Protein CBR-RGA-1
member entity reference: Rho-GTPase-activating protein 8
member entity reference: Rho GTPase-activating protein 68F

uniprot P18168 744
type: UnificationXref
id: P18168
db: uniprot

uniprot F6QUW1 168
type: UnificationXref
id: F6QUW1
db: uniprot

uniprot A1L570 1027
type: UnificationXref
id: A1L570
db: uniprot

VEGF
type: Protein
entity reference: VEGF
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa25 1321
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P54676 951
type: UnificationXref
id: P54676
db: uniprot

uniprot A0A2I3SR38 549
type: UnificationXref
id: A0A2I3SR38
db: uniprot

uniprot P05412 542
type: UnificationXref
id: P05412
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5Q5Z6 280
xref: PTHR24055:SF393
organism: Macaca mulatta

Delta-like protein
type: ProteinReference
xref: PTHR24044:SF448
xref: uniprot E2QUR0 722
organism: Canis lupus familiaris

uniprot F1QBI2 116
type: UnificationXref
id: F1QBI2
db: uniprot

uniprot F7HAE1 1182
type: UnificationXref
id: F7HAE1
db: uniprot

uniprot F7CN41 400
type: UnificationXref
id: F7CN41
db: uniprot

JNKK1
type: Protein
entity reference: JNKK1
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q9VXH3 1287
organism: Drosophila melanogaster

Growth factor receptor-bound protein 7
type: ProteinReference
xref: PTHR11243:SF25
xref: uniprot Q14451 783
organism: Homo sapiens

STAT1
type: ProteinReference
xref: P00218
standard name: Signal transducers and activators of transcription 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Signal Transducer and Activator of Transcription 1 Synonym: Synonym not specified Accession: P00218
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.STAT1
member entity reference: Signal transducer and activator of transcription 1-alpha/beta
member entity reference: Signal transducer and activator of transcription 1
member entity reference: Signal transducer and activator of transcription

Survivin
type: Protein
entity reference: Survivin
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Platelet-derived growth factor receptor alpha
type: ProteinReference
xref: uniprot P16234 792
xref: PTHR24416:SF52
organism: Homo sapiens

uniprot Q9H1J7 390
type: UnificationXref
id: Q9H1J7
db: uniprot

PARTICIPANT STOICHIOMETRY r244 1512
type: Stoichiometry
physical entity: MEKK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r244 1511
type: Stoichiometry
physical entity: MEKK1
stoichiometric coefficient: 1.0

Crk
type: Protein
entity reference: Crk
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Survivin-RIGHT__Survivin-_r255
controller: Akt

uniprot P04628 360
type: UnificationXref
id: P04628
db: uniprot

Ang-2
type: ProteinReference
xref: P00246
standard name: Angiopoietin-2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Angiopoietin-2 Synonym: Synonym not specified Accession: P00246
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Ang-2
member entity reference: ANGPT2 isoform 1
member entity reference: Angiopoietin-2
member entity reference: Uncharacterized protein
member entity reference: Angiopoietin 2
member entity reference: Angiogenin-2

PLA2
type: Protein
entity reference: PLA2
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Growth factor receptor-bound protein 14
type: ProteinReference
xref: PTHR11243:SF22
xref: uniprot Q14449 230
organism: Homo sapiens

uniprot A4FTT3 841
type: UnificationXref
id: A4FTT3
db: uniprot

Vascular endothelial growth factor A
type: ProteinReference
xref: uniprot P67964 1061
organism: Gallus gallus

VEGF s57 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VEGF
stoichiometric coefficient: 1.0

uniprot Q07498 482
type: UnificationXref
id: Q07498
db: uniprot

Grb14
type: Protein
entity reference: Grb14
feature: ACTIVE 25
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

FVIIa
type: ProteinReference
xref: P00201
standard name: Factor VIIa
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.FVIIa
comment: ENTITY_REFERENCE_NOTES=Long Name: Factor VIIa Synonym: Coagulation Factor VII Accession: P00201
member entity reference: Coagulation factor VII

PTHR10373:SF32
type: RelationshipXref
id: PTHR10373:SF32
db: PANTHER Family
relationship type: By Homology

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot E2R6T4 539
organism: Canis lupus familiaris

uniprot A0A1D5RE70 320
type: UnificationXref
id: A0A1D5RE70
db: uniprot

DLL3 isoform 4
type: ProteinReference
xref: uniprot A0A2I3RGF5 714
xref: PTHR24044:SF308
organism: Pan troglodytes

uniprot Q05030 795
type: UnificationXref
id: Q05030
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
type: ProteinReference
xref: uniprot F7BZL6 914
xref: PTHR10155:SF3
organism: Macaca mulatta

uniprot Q09914 1230
type: UnificationXref
id: Q09914
db: uniprot

PKC
type: Protein
entity reference: PKC
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot H2QLB4 289
type: UnificationXref
id: H2QLB4
db: uniprot

uniprot P12841 876
type: UnificationXref
id: P12841
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC_gamma-RIGHT__PLC_gamma-_r203
controller: Complex (FGFR-1/FGF)

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_r182
controller: Raf

uniprot E1B7L9 555
type: UnificationXref
id: E1B7L9
db: uniprot

uniprot E2RB53 443
type: UnificationXref
id: E2RB53
db: uniprot

Grb14
type: ProteinReference
xref: P00197
standard name: Growth Factor Receptor-Bound Protein 14
comment: ENTITY_REFERENCE_NOTES=Long Name: Growth Factor Receptor-Bound Protein 14 Synonym: Adaptor Protein 14 Accession: P00197
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiogenesis.PROTEIN.GENERIC.Grb14
member entity reference: Growth factor receptor-bound protein 14
member entity reference: GRB14 isoform 2

uniprot Q92050 385
type: UnificationXref
id: Q92050
db: uniprot

Frizzled-5
type: ProteinReference
xref: uniprot Q9EQD0 138
xref: PTHR11309:SF136
organism: Mus musculus

PIK3CG isoform 1
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot A0A2J8QY32 886
organism: Pan troglodytes

STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_r292
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r292 1549
participant stoichiometry: PARTICIPANT STOICHIOMETRY r292 1548
left: HSP27
interaction type: STATE_TRANSITION
right: HSP27

PARTICIPANT STOICHIOMETRY r267 1447
type: Stoichiometry
physical entity: Complex (Tie2/Ang-1)
stoichiometric coefficient: 1.0

Protein Wnt
type: ProteinReference
xref: PTHR12027:SF78
xref: uniprot Q4JLT0 381
organism: Danio rerio

Ras guanine nucleotide exchange factor Y
type: ProteinReference
xref: uniprot Q552M5 181
organism: Dictyostelium discoideum

uniprot E2RGQ1 424
type: UnificationXref
id: E2RGQ1
db: uniprot

Tie2
type: Protein
entity reference: Tie2
feature: COMPLEX PARTICIPANT BINDING FEATURE s225 sa235 1297
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q6AYD8 1123
type: UnificationXref
id: Q6AYD8
db: uniprot

uniprot F1N0M5 1030
type: UnificationXref
id: F1N0M5
db: uniprot

PARTICIPANT STOICHIOMETRY r267 1445
type: Stoichiometry
physical entity: Tie2
stoichiometric coefficient: 1.0

uniprot Q04589 72
type: UnificationXref
id: Q04589
db: uniprot

PARTICIPANT STOICHIOMETRY r267 1446
type: Stoichiometry
physical entity: Ang-1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CSL-RIGHT__CSL-_r146
controller: Complex (Notch/Delta/ Serrate)