Raf1
type: ProteinReference
xref: P05928
standard name: RAF proto-oncogene serine/threonine-protein kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: c-Raf-1 Synonym: MAPKKK Accession: P05928
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.Raf1
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: Uncharacterized protein

uniprot F1MX21 204
type: UnificationXref
id: F1MX21
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 79
xref: PTHR44329:SF22
xref: uniprot P04049 78
organism: Homo sapiens

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 3

uniprot P29387 156
type: UnificationXref
id: P29387
db: uniprot

uniprot H2QSU0 211
type: UnificationXref
id: H2QSU0
db: uniprot

uniprot A0A2R8QPB8 267
type: UnificationXref
id: A0A2R8QPB8
db: uniprot

uniprot P43250 256
type: UnificationXref
id: P43250
db: uniprot

GRK6
type: ProteinReference
xref: P05939
standard name: G protein-coupled receptor kinase 6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.GRK6
comment: ENTITY_REFERENCE_NOTES=Long Name: G protein-coupled receptor kinase 6 Synonym: Synonym not specified Accession: P05939
member entity reference: G protein-coupled receptor kinase 6
member entity reference: G protein-coupled receptor kinase

uniprot F7C5A3 268
type: UnificationXref
id: F7C5A3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot A4IFL6 85
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RBE7 91
xref: PTHR13809:SF1
organism: Canis lupus familiaris

Early growth response protein 1
type: ProteinReference
xref: uniprot Q29W20 178
organism: Bos taurus

uniprot P28482 241
type: UnificationXref
id: P28482
db: uniprot

STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 337
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 336
left: MAPK
interaction type: STATE_TRANSITION
right: MAPK

uniprot F7FXA9 147
type: UnificationXref
id: F7FXA9
db: uniprot

ncbitaxon 9544 11
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot A0A3S5ZPX3 52
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 22

PARTICIPANT STOICHIOMETRY re28 372
type: Stoichiometry
physical entity: RhoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 358
type: Stoichiometry
physical entity: CRAC
stoichiometric coefficient: 1.0

Ggamma s35 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 371
type: Stoichiometry
physical entity: RhoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 359
type: Stoichiometry
physical entity: CRAC
stoichiometric coefficient: 1.0

DAG
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gqalpha s16 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gqalpha
stoichiometric coefficient: 1.0

Gqalpha s10 sa11 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P28482 241
organism: Homo sapiens

uniprot F7CTP1 143
type: UnificationXref
id: F7CTP1
db: uniprot

uniprot Q66JE6 68
type: UnificationXref
id: Q66JE6
db: uniprot

uniprot F7EBE7 146
type: UnificationXref
id: F7EBE7
db: uniprot

uniprot A0A2I3THL4 75
type: UnificationXref
id: A0A2I3THL4
db: uniprot

uniprot P41969 224
type: UnificationXref
id: P41969
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 164
xref: PTHR19850:SF27
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 163
xref: PTHR19850:SF29
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 161
xref: PTHR19850:SF29
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 162
xref: PTHR19850:SF29
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: PTHR19850:SF36
xref: uniprot P62881 166
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RhoA-RIGHT__RhoA-_re28
controller: beta-ARR1

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot P62880 165
organism: Mus musculus

Beta-arrestin-2
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot Q91YI4 21
organism: Mus musculus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot Q14643 219
organism: Homo sapiens

PTHR10218:SF316
type: RelationshipXref
id: PTHR10218:SF316
db: PANTHER Family
relationship type: By Homology

PLC
type: ProteinReference
xref: P05933
standard name: phospholipase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.PLC
comment: ENTITY_REFERENCE_NOTES=Long Name: phospholipase C Synonym: Synonym not specified Accession: P05933
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

IP3R
type: Protein
entity reference: IP3R
feature: ACTIVE 23
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 240
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re9 327
type: Stoichiometry
physical entity: beta-ARR1
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q01970 195
xref: PTHR10336:SF11
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re9 328
type: Stoichiometry
physical entity: beta-ARR1
stoichiometric coefficient: 1.0

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

uniprot P34947 263
type: UnificationXref
id: P34947
db: uniprot

uniprot P30671 112
type: UnificationXref
id: P30671
db: uniprot

Raf1 s73 sa54 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.927988476219284
comment: MODIFICATION_RESIDUE_NAME=

uniprot H2R1Z2 36
type: UnificationXref
id: H2R1Z2
db: uniprot

PARTICIPANT STOICHIOMETRY re12 363
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 362
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 160
xref: PTHR19850:SF29
organism: Bos taurus

uniprot E2RBE7 91
type: UnificationXref
id: E2RBE7
db: uniprot

uniprot P36507 61
type: UnificationXref
id: P36507
db: uniprot

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot A4GTP4 222
organism: Rattus norvegicus

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q01986 62
organism: Rattus norvegicus

ncbitaxon 9598 13
type: UnificationXref
id: 9598
db: ncbitaxon

MAPK s76 sa58 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot F7CTP1 143
organism: Macaca mulatta

Beta-arrestin-1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot P17870 37
organism: Bos taurus

Ggamma
type: ProteinReference
xref: P05929
standard name: G-protein, gamma subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.G_gamma_
comment: ENTITY_REFERENCE_NOTES= Long Name: G-protein, gamma subunit Synonym: Synonym not specified Accession: P05929
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

Raf1 s88 sa66 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.927988476219284
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re23 382
type: Stoichiometry
physical entity: Raf1
stoichiometric coefficient: 1.0

Early growth response protein 1
type: ProteinReference
xref: uniprot P08154 175
organism: Rattus norvegicus

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

STATE_TRANSITION_LEFT__CRAC-RIGHT__CRAC-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 358
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 359
left: CRAC
interaction type: STATE_TRANSITION
right: CRAC

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 13

uniprot A0A2J8QDF6 181
type: UnificationXref
id: A0A2J8QDF6
db: uniprot

uniprot Q8VEB1 266
type: UnificationXref
id: Q8VEB1
db: uniprot

uniprot P61952 118
type: UnificationXref
id: P61952
db: uniprot

MAPK
type: Protein
entity reference: MAPK
feature: MAPK s91 sa70 rs1
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
evidence: Evidence 74
evidence: Evidence 72
evidence: Evidence 71
evidence: Evidence 73
xref: PTHR44329:SF22
xref: uniprot A0A1D5R9U8 70
organism: Macaca mulatta

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot E2R5J6 276
organism: Canis lupus familiaris

uniprot P01015 227
type: UnificationXref
id: P01015
db: uniprot

Type-1 angiotensin II receptor
type: ProteinReference
xref: uniprot P25104 26
organism: Bos taurus

Gbeta s27 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P41969 224
organism: Mus musculus

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F1NYZ2 53
organism: Gallus gallus

IP3R
type: Protein
entity reference: IP3R
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot F6YZA3 99
type: UnificationXref
id: F6YZA3
db: uniprot

PARTICIPANT STOICHIOMETRY re23 383
type: Stoichiometry
physical entity: Raf1
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot Q5E9F0 128
organism: Bos taurus

ncbitaxon 9031 32
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot Q5F3B5 50
type: UnificationXref
id: Q5F3B5
db: uniprot

uniprot Q61011 168
type: UnificationXref
id: Q61011
db: uniprot

STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_re25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 379
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 378
left: MAPK
interaction type: STATE_TRANSITION
right: MAPK

DISSOCIATION_LEFT__AngII_AT1_R_complex-RIGHT__AngII-_AT1_R-_re7
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 333
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 331
left: AngII/AT1-R complex
interaction type: DISSOCIATION
right: AT1-R
right: AngII

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 82
xref: uniprot P11345 81
xref: PTHR44329:SF22
organism: Rattus norvegicus

Gqalpha s33 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gqalpha
stoichiometric coefficient: 1.0

uniprot F6XWE8 98
type: UnificationXref
id: F6XWE8
db: uniprot

STATE_TRANSITION_LEFT__RhoA-RIGHT__RhoA-_re28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 372
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 371
left: RhoA
interaction type: STATE_TRANSITION
right: RhoA

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa14 326
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P10894 192
type: UnificationXref
id: P10894
db: uniprot

uniprot B8JLJ7 41
type: UnificationXref
id: B8JLJ7
db: uniprot

PARTICIPANT STOICHIOMETRY re6 335
type: Stoichiometry
physical entity: GRK2
stoichiometric coefficient: 1.0

Novel Rho protein
type: ProteinReference
xref: uniprot Q28HZ4 248
xref: PTHR24072:SF100
organism: Xenopus tropicalis

Protein kinase C
type: ProteinReference
xref: uniprot F6RA79 283
xref: PTHR24356:SF193
organism: Monodelphis domestica

AT1 R s38 sa24 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 139
xref: PTHR19850:SF29
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 244
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re6 334
type: Stoichiometry
physical entity: GRK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 367
type: Stoichiometry
physical entity: beta-ARR2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 368
type: Stoichiometry
physical entity: beta-ARR2
stoichiometric coefficient: 1.0

uniprot P63215 124
type: UnificationXref
id: P63215
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot Q28FH0 48
type: UnificationXref
id: Q28FH0
db: uniprot

uniprot J9P5W6 56
type: UnificationXref
id: J9P5W6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot E2R9G5 90
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 153
xref: PTHR19850:SF36
organism: Homo sapiens

uniprot A0A2I3SSC7 199
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A2I3SSC7 199
organism: Pan troglodytes

Evidence 71
type: Evidence
evidence code: ISS
comment: SPACC P04049

TRIGGER
type: Control
xref: TRIGGER
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re13
control type: ACTIVATION
controller: IP3R

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 137
xref: PTHR19850:SF28
organism: Canis lupus familiaris

Evidence 72
type: Evidence
evidence code: ISS
comment: SPACC P05625

Evidence 73
type: Evidence
evidence code: ISS
comment: SPACC P11345

Evidence 74
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot E2R2S3 89
organism: Canis lupus familiaris

Evidence 79
type: Evidence
evidence code: RCA
comment: SPACC P04049

uniprot P51432 193
type: UnificationXref
id: P51432
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__AngII_AT1_R_complex-RIGHT__AngII-_AT1_R-_re7
controller: GRK3

b-ArrAT1aR
type: Complex
component stoichiometry: AT1 R s85 sa73 STOICHIOMETRY ID COMPLEX
component stoichiometry: beta ARR2 s86 sa74 STOICHIOMETRY ID COMPLEX
component: beta-ARR2
component: AT1-R
feature: COMPLEX BINDING FEATURE s94 csa7 291
feature: ACTIVE 23
feature: COMPLEX BINDING FEATURE s94 csa7 293
cellular location: cytosol

MODULATION
type: RelationshipTypeVocabulary

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 11

uniprot F7EI48 235
type: UnificationXref
id: F7EI48
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot P32121 19
type: UnificationXref
id: P32121
db: uniprot

Type-1 angiotensin II receptor
type: ProteinReference
xref: uniprot P30556 30
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 238
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf1-RIGHT__Raf1-_re17
controller: PKC

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_re24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 381
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 380
left: MEK
interaction type: STATE_TRANSITION
right: MEK

PARTICIPANT STOICHIOMETRY re5 338
type: Stoichiometry
physical entity: GRK3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 339
type: Stoichiometry
physical entity: GRK3
stoichiometric coefficient: 1.0

uniprot A0A1D5Q4D0 179
type: UnificationXref
id: A0A1D5Q4D0
db: uniprot

Gqalpha s16 sa7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot F1MYW8 93
type: UnificationXref
id: F1MYW8
db: uniprot

Ggamma s28 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

PTHR19850:SF27
type: RelationshipXref
id: PTHR19850:SF27
db: PANTHER Family
relationship type: By Homology

uniprot H2Q482 277
type: UnificationXref
id: H2Q482
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 72
xref: uniprot P05625 80
xref: PTHR44329:SF22
organism: Gallus gallus

uniprot E2R2S3 89
type: UnificationXref
id: E2R2S3
db: uniprot

uniprot F6V461 96
type: UnificationXref
id: F6V461
db: uniprot

uniprot E2R5J6 276
type: UnificationXref
id: E2R5J6
db: uniprot

uniprot F6TFY2 95
type: UnificationXref
id: F6TFY2
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

PTHR19850:SF29
type: RelationshipXref
id: PTHR19850:SF29
db: PANTHER Family
relationship type: By Homology

uniprot P70227 216
type: UnificationXref
id: P70227
db: uniprot

PTHR19850:SF28
type: RelationshipXref
id: PTHR19850:SF28
db: PANTHER Family
relationship type: By Homology

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot F7FY59 254
xref: PTHR24355:SF15
organism: Macaca mulatta

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF15
xref: uniprot F6X9W7 253
organism: Canis lupus familiaris

Early growth response protein
type: ProteinReference
xref: uniprot E2RBP5 172
organism: Canis lupus familiaris

uniprot E2RLH2 245
type: UnificationXref
id: E2RLH2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 114
xref: PTHR13809:SF21
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 115
xref: PTHR13809:SF6
organism: Homo sapiens

MAPK
type: Protein
entity reference: MAPK
feature: MAPK s78 sa59 rs1
feature: ACTIVE 23
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9615 7
type: UnificationXref
id: 9615
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 117
xref: PTHR13809:SF28
organism: Bos taurus

AT1 R s22 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AT1-R
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50153 116
organism: Mus musculus

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P50148 47
organism: Homo sapiens

MAPK s92 sa71 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

Evidence 84
type: Evidence
evidence code: RCA
comment: SPACC Q99N57

Evidence 82
type: Evidence
evidence code: RCA
comment: SPACC P11345

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot F6XT65 55
organism: Monodelphis domestica

Beta-adrenergic receptor kinase 1
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot P21146 278
organism: Bos taurus

uniprot A0A1D5R9U8 70
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

GO GO:0005829 5
type: UnificationXref
id: GO:0005829
db: GO

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re16
controller: Ca2+

uniprot E1BQG4 258
type: UnificationXref
id: E1BQG4
db: uniprot

uniprot E2R2S8 137
type: UnificationXref
id: E2R2S8
db: uniprot

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa9 308
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

AT1 R s85 sa73 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

uniprot F7E823 233
type: UnificationXref
id: F7E823
db: uniprot

uniprot Q28GJ8 247
type: UnificationXref
id: Q28GJ8
db: uniprot

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 351
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 352
left: PKC
interaction type: STATE_TRANSITION
right: PKC

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot A3KGF7 182
xref: PTHR10336:SF10
organism: Mus musculus

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa22 302
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot E2RHY4 138
type: UnificationXref
id: E2RHY4
db: uniprot

PTHR19850:SF36
type: RelationshipXref
id: PTHR19850:SF36
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__AngII-_AT1R_G_protein_complex-RIGHT__AngII_AT1_R_G_protein_complex-_re3
controller: GRK5

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__AngII-_AT1R_G_protein_complex-RIGHT__AngII_AT1_R_G_protein_complex-_re3
controller: GRK6

PTHR19850:SF31
type: RelationshipXref
id: PTHR19850:SF31
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5R973 24
type: UnificationXref
id: A0A1D5R973
db: uniprot

uniprot P62880 165
type: UnificationXref
id: P62880
db: uniprot

beta ARR2 s86 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: beta-ARR2
stoichiometric coefficient: 1.0

G protein subunit beta 5
type: ProteinReference
xref: PTHR19850:SF36
xref: uniprot H2Q9G5 150
organism: Pan troglodytes

Early growth response protein 1
type: ProteinReference
xref: uniprot P26632 177
organism: Danio rerio

uniprot F7EH19 234
type: UnificationXref
id: F7EH19
db: uniprot

PTHR13809:SF1
type: RelationshipXref
id: PTHR13809:SF1
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot H2QDQ1 284
organism: Pan troglodytes

uniprot A0A1D5QUZ8 230
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

Raf1
type: Protein
entity reference: Raf1
feature: Raf1 s88 sa66 rs1
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

PTHR10336:SF11
type: RelationshipXref
id: PTHR10336:SF11
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF12
type: RelationshipXref
id: PTHR10336:SF12
db: PANTHER Family
relationship type: By Homology

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P1X4 205
xref: PTHR13715:SF53
organism: Gallus gallus

PTHR10336:SF10
type: RelationshipXref
id: PTHR10336:SF10
db: PANTHER Family
relationship type: By Homology

EGR
type: Protein
entity reference: EGR
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot P63216 125
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot P63215 124
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot P63214 123
organism: Bos taurus

uniprot C3PTE8 33
type: UnificationXref
id: C3PTE8
db: uniprot

Angiotensinogen
type: ProteinReference
xref: uniprot P11859 229
organism: Mus musculus

uniprot F7ES96 101
type: UnificationXref
id: F7ES96
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot P51432 193
xref: PTHR10336:SF11
organism: Mus musculus

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 74
evidence: Evidence 72
evidence: Evidence 71
evidence: Evidence 73
xref: uniprot E2REI6 76
xref: PTHR44329:SF22
organism: Canis lupus familiaris

uniprot F1PJE5 94
type: UnificationXref
id: F1PJE5
db: uniprot

G protein-coupled receptor kinase 6
type: ProteinReference
xref: PTHR24355:SF15
xref: uniprot O70293 255
organism: Mus musculus

uniprot Q9QUI0 251
type: UnificationXref
id: Q9QUI0
db: uniprot

AT1 R s85 sa73 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__beta_ARR1-RIGHT__beta_ARR1-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 327
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 328
left: beta-ARR1
interaction type: STATE_TRANSITION
right: beta-ARR1

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot Q9CXP8 131
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6ZKL2 186
xref: PTHR10336:SF12
organism: Macaca mulatta

uniprot F6Y3N2 141
type: UnificationXref
id: F6Y3N2
db: uniprot

beta-ARR2
type: Protein
entity reference: beta-ARR2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein subunit alpha q
type: ProteinReference
xref: uniprot E1BA29 42
xref: PTHR10218:SF316
organism: Bos taurus

uniprot Q29W20 178
type: UnificationXref
id: Q29W20
db: uniprot

AT1R/G protein complex
type: Complex
component stoichiometry: Gbeta s11 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s12 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gqalpha s10 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: AT1 R s22 sa1 STOICHIOMETRY ID COMPLEX
component: Ggamma
component: Gbeta
component: AT1-R
component: Gqalpha
feature: COMPLEX BINDING FEATURE s21 csa3 311
feature: COMPLEX BINDING FEATURE s21 csa3 309
feature: COMPLEX BINDING FEATURE s21 csa3 315
feature: COMPLEX BINDING FEATURE s21 csa3 313
cellular location: cytosol

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 235
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2R2N2 232
xref: PTHR24055:SF203
organism: Canis lupus familiaris

Raf1
type: Protein
entity reference: Raf1
feature: Raf1 s88 sa67 rs1
feature: ACTIVE 23
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

uniprot P29995 215
type: UnificationXref
id: P29995
db: uniprot

uniprot Q00722 194
type: UnificationXref
id: Q00722
db: uniprot

GO GO:0005768 2
type: UnificationXref
id: GO:0005768
db: GO

Ras homolog family member A
type: ProteinReference
xref: uniprot Q28GJ8 247
xref: PTHR24072:SF153
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY re16 352
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 351
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

TRANSPORT
type: RelationshipTypeVocabulary

EGR
type: ProteinReference
xref: P05931
standard name: early growth response
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.EGR
comment: ENTITY_REFERENCE_NOTES=Long Name: early growth response Synonym: KROX24,NGFIA Accession: P05931
member entity reference: Early growth response protein 1
member entity reference: Early growth response protein

uniprot F6RA79 283
type: UnificationXref
id: F6RA79
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__AngII_AT1_R_complex-RIGHT__AngII-_AT1_R-_re7
controller: GRK2

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 16

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot Q3SZ98 127
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F6SD46 185
organism: Monodelphis domestica

uniprot P62872 161
type: UnificationXref
id: P62872
db: uniprot

Type-1B angiotensin II receptor
type: ProteinReference
xref: uniprot P29089 27
organism: Rattus norvegicus

ncbitaxon 10116 15
type: UnificationXref
id: 10116
db: ncbitaxon

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P11881 213
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__beta_ARR1-RIGHT__beta_ARR1-_re9
controller: AT1-R

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 105
xref: PTHR13809:SF21
organism: Pan troglodytes

uniprot Q14573 218
type: UnificationXref
id: Q14573
db: uniprot

PARTICIPANT STOICHIOMETRY re8 330
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

uniprot P25104 26
type: UnificationXref
id: P25104
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 8

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P52287 157
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9Z1B3 198
xref: PTHR10336:SF12
organism: Mus musculus

uniprot H2QDQ1 284
type: UnificationXref
id: H2QDQ1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ELK1-RIGHT__ELK1-_re20
controller: MAPK

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot Q00722 194
xref: PTHR10336:SF10
organism: Homo sapiens

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re8 329
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re16
controller: DAG

uniprot P25095 25
type: UnificationXref
id: P25095
db: uniprot

uniprot H9FU38 212
type: UnificationXref
id: H9FU38
db: uniprot

AT1-R
type: Protein
entity reference: AT1-R
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa73 292
feature: AT1 R s85 sa73 rs2
feature: AT1 R s85 sa73 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G1K7 43
xref: PTHR10218:SF316
organism: Monodelphis domestica

Type-1A angiotensin II receptor
type: ProteinReference
xref: uniprot P25095 25
organism: Rattus norvegicus

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 44

uniprot P50148 47
type: UnificationXref
id: P50148
db: uniprot

Beta-adrenergic receptor kinase 1
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot P25098 279
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 108
xref: PTHR13809:SF6
organism: Pan troglodytes

AngII
type: ProteinReference
xref: P05935
standard name: Angiotensin II
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.AngII
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Angiotensin II Synonym: Synonym not specified Accession: P05935
member entity reference: Angiotensinogen
member entity reference: AGT isoform 1
member entity reference: Uncharacterized protein

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 136
xref: PTHR19850:SF28
organism: Gallus gallus

HETERODIMER_ASSOCIATION_LEFT__G_protein-_AT1_R-RIGHT__AT1R_G_protein_complex-_re2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 354
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 355
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 353
left: AT1-R
left: G protein
interaction type: HETERODIMER_ASSOCIATION
right: AT1R/G protein complex

uniprot A0A3Q2UD13 201
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

uniprot P49407 39
type: UnificationXref
id: P49407
db: uniprot

PTHR13809:SF6
type: RelationshipXref
id: PTHR13809:SF6
db: PANTHER Family
relationship type: By Homology

PTHR13809:SF8
type: RelationshipXref
id: PTHR13809:SF8
db: PANTHER Family
relationship type: By Homology

Type-1B angiotensin II receptor
type: ProteinReference
xref: uniprot P29755 29
organism: Mus musculus

Type-1A angiotensin II receptor
type: ProteinReference
xref: uniprot P29754 28
organism: Mus musculus

AT1 R s51 sa32 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q62833 265
type: UnificationXref
id: Q62833
db: uniprot

Angiotensinogen
type: ProteinReference
xref: uniprot P01015 227
organism: Rattus norvegicus

uniprot A0A3Q1N7P8 200
type: UnificationXref
id: A0A3Q1N7P8
db: uniprot

uniprot Q3SZ98 127
type: UnificationXref
id: Q3SZ98
db: uniprot

uniprot A0A1D5QKD3 51
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa20 300
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6XT65 55
type: UnificationXref
id: F6XT65
db: uniprot

IP3R
type: ProteinReference
xref: P05932
standard name: inositol 1,4,5-triphosphate receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES=Long Name: inositol 1,4,5-triphosphate receptor Synonym: Synonym not specified Accession: P05932
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.ION_CHANNEL.IP3R
member entity reference: Inositol 1,4,5-trisphosphate receptor type 3
member entity reference: Inositol 1,4,5-trisphosphate receptor type 2
member entity reference: Uncharacterized protein
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1 isoform 3

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot F6R543 206
xref: PTHR13715:SF51
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 148
xref: PTHR19850:SF28
organism: Monodelphis domestica

AT1 R s51 sa32 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

uniprot E1BP29 252
type: UnificationXref
id: E1BP29
db: uniprot

Ggamma s12 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P20444 286
xref: PTHR24356:SF193
organism: Mus musculus

uniprot P30556 30
type: UnificationXref
id: P30556
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa8 306
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

GRK5
type: Protein
entity reference: GRK5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR13715:SF51
type: RelationshipXref
id: PTHR13715:SF51
db: PANTHER Family
relationship type: By Homology

PTHR13715:SF53
type: RelationshipXref
id: PTHR13715:SF53
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 171
xref: PTHR19850:SF28
organism: Homo sapiens

AT1 R s1 sa16 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

AT1-R
type: Protein
entity reference: AT1-R
feature: AT1 R s1 sa16 rs1
feature: AT1 R s1 sa16 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q3KRE3 126
type: UnificationXref
id: Q3KRE3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot E2RJB3 92
organism: Canis lupus familiaris

ARRB1 isoform 1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot H2R1Z2 36
organism: Pan troglodytes

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 74
evidence: Evidence 72
evidence: Evidence 71
evidence: Evidence 73
xref: PTHR44329:SF22
xref: uniprot A0A2I3THL4 75
organism: Pan troglodytes

AT1-R
type: Protein
entity reference: AT1-R
feature: AT1 R s32 sa4 rs2
feature: ACTIVE 23
feature: AT1 R s32 sa4 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa4 320
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A2I3T8F7 180
xref: PTHR10336:SF11
organism: Pan troglodytes

AT1 R s1 sa16 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 239
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot F1PJE5 94
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot Q99JE6 196
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot Q9UK08 132
organism: Homo sapiens

uniprot P20444 286
type: UnificationXref
id: P20444
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot P29995 215
xref: PTHR13715:SF53
organism: Rattus norvegicus

uniprot Q6DHM9 250
type: UnificationXref
id: Q6DHM9
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P29994 214
organism: Rattus norvegicus

uniprot P32120 17
type: UnificationXref
id: P32120
db: uniprot

MAPK
type: ProteinReference
xref: P05937
standard name: mitogen-activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: mitogen-activated protein kinase Synonym: ERK Accession: P05937
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.MAPK
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Uncharacterized protein

MEK
type: Protein
entity reference: MEK
feature: MEK s74 sa55 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Danio rerio
type: BioSource
xref: ncbitaxon 7955 34

G protein subunit alpha q
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot K6ZCJ5 45
organism: Pan troglodytes

AngII
type: Protein
entity reference: AngII
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa23 296
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_re18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 341
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 340
left: MEK
interaction type: STATE_TRANSITION
right: MEK

ncbitaxon 7955 34
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot O60262 111
type: UnificationXref
id: O60262
db: uniprot

AT1-R
type: ProteinReference
xref: P05924
standard name: angiotensin type II 1a receptor
comment: ENTITY_REFERENCE_NOTES=Long Name: angiotensin type II 1a receptor Synonym: AGTR1,angiotensin receptor 1 Accession: P05924
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.RECEPTOR.AT1_minus_R
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Type-1 angiotensin II receptor
member entity reference: Type-1B angiotensin II receptor
member entity reference: Type-1A angiotensin II receptor
member entity reference: Uncharacterized protein

uniprot P21146 278
type: UnificationXref
id: P21146
db: uniprot

Beta-arrestin-2
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot P29067 14
organism: Rattus norvegicus

Angiotensinogen
type: ProteinReference
xref: uniprot P01019 228
organism: Homo sapiens

Beta-arrestin-1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot P29066 38
organism: Rattus norvegicus

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa15 316
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 133
xref: PTHR19850:SF27
organism: Pan troglodytes

uniprot A0A2I3T8F7 180
type: UnificationXref
id: A0A2I3T8F7
db: uniprot

uniprot P79785 31
type: UnificationXref
id: P79785
db: uniprot

uniprot A0A3Q1NGS8 134
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot E1BKE7 202
xref: PTHR13715:SF51
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 242
organism: Mus musculus

MEK
type: ProteinReference
xref: P05926
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.MEK
comment: ENTITY_REFERENCE_NOTES=Long Name: mitogen-activated or extracellular signal-regulated protein kinase Synonym: MAPKK,mitogen-activated protein kinase kinase Accession: P05926
member entity reference: Uncharacterized protein
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: MAP2K2 isoform 1
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: MAP2K1 protein
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: Mitogen-activated protein kinase kinase 2

TRIGGER
type: Control
xref: TRIGGER
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re15
control type: ACTIVATION
controller: CRAC

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63086 243
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 99
xref: PTHR13809:SF19
organism: Monodelphis domestica

uniprot P29089 27
type: UnificationXref
id: P29089
db: uniprot

uniprot F6S9S9 54
type: UnificationXref
id: F6S9S9
db: uniprot

GRK3
type: ProteinReference
xref: P05941
standard name: G protein-coupled receptor kinase 3
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.GRK3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: G protein-coupled receptor kinase 3 Synonym: ADRBK2,BARK2,beta-adrenergic receptor kinase 2 Accession: P05941
member entity reference: Beta-adrenergic receptor kinase 2
member entity reference: G protein-coupled receptor kinase

Type-1 angiotensin II receptor
type: ProteinReference
xref: uniprot P79785 31
organism: Gallus gallus

uniprot G3V8K2 104
type: UnificationXref
id: G3V8K2
db: uniprot

uniprot F6R543 206
type: UnificationXref
id: F6R543
db: uniprot

Ggamma s15 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Gbeta s14 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__beta_ARR2-RIGHT__beta_ARR2-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 368
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 367
left: beta-ARR2
interaction type: STATE_TRANSITION
right: beta-ARR2

Uncharacterized protein
type: ProteinReference
evidence: Evidence 74
evidence: Evidence 72
evidence: Evidence 71
evidence: Evidence 73
xref: uniprot F7BRK5 77
xref: PTHR44329:SF22
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q02750 63
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re25 379
type: Stoichiometry
physical entity: MAPK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 378
type: Stoichiometry
physical entity: MAPK
stoichiometric coefficient: 1.0

uniprot F7BB02 100
type: UnificationXref
id: F7BB02
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF27
xref: uniprot F7DA21 260
organism: Monodelphis domestica

eco ECO:0000250 8
type: UnificationXref
id: ECO:0000250
db: eco

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 95
xref: PTHR13809:SF21
organism: Macaca mulatta

uniprot Q99N57 83
type: UnificationXref
id: Q99N57
db: uniprot

uniprot P54311 158
type: UnificationXref
id: P54311
db: uniprot

uniprot F1PL90 184
type: UnificationXref
id: F1PL90
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: MEK s75 sa57 rs1
feature: ACTIVE 23
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot K7BA21 189
organism: Pan troglodytes

ELK1
type: Protein
entity reference: ELK1
feature: ELK1 s77 sa60 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Beta-arrestin-1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot Q8BWG8 40
organism: Mus musculus

HETERODIMER_ASSOCIATION_LEFT__beta_ARR2-_AT1_R-RIGHT__b_ArrAT1aR-_re26
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 375
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 376
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 377
left: AT1-R
left: beta-ARR2
interaction type: HETERODIMER_ASSOCIATION
right: b-ArrAT1aR

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 15

G protein-coupled receptor kinase 6
type: ProteinReference
xref: PTHR24355:SF15
xref: uniprot P97711 257
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot F6UHL5 10
organism: Macaca mulatta

beta ARR2 s97 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: beta-ARR2
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot P29994 214
type: UnificationXref
id: P29994
db: uniprot

uniprot E2RT75 183
type: UnificationXref
id: E2RT75
db: uniprot

GRK2
type: Protein
entity reference: GRK2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2QNS5 151
type: UnificationXref
id: H2QNS5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot P63078 122
organism: Mus musculus

uniprot F6PVT7 140
type: UnificationXref
id: F6PVT7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot P63077 121
organism: Rattus norvegicus

uniprot P36506 60
type: UnificationXref
id: P36506
db: uniprot

uniprot E2REI6 76
type: UnificationXref
id: E2REI6
db: uniprot

AngII s31 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AngII
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 347
type: Stoichiometry
physical entity: Raf1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 346
type: Stoichiometry
physical entity: Raf1
stoichiometric coefficient: 1.0

RhoA
type: ProteinReference
xref: P05938
standard name: RhoA GTPase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.RhoA
comment: ENTITY_REFERENCE_NOTES=Long Name: RhoA GTPase Synonym: ARHA Accession: P05938
member entity reference: Transforming protein RhoA
member entity reference: Novel Rho protein
member entity reference: Uncharacterized protein
member entity reference: Ras homolog family member A
member entity reference: Rho-related GTP-binding protein RhoA-B
member entity reference: Rho-related GTP-binding protein RhoA-D

uniprot H9ZA60 187
type: UnificationXref
id: H9ZA60
db: uniprot

Gbeta s11 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

uniprot E2R2N2 232
type: UnificationXref
id: E2R2N2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 159
xref: PTHR19850:SF27
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 158
xref: PTHR19850:SF29
organism: Rattus norvegicus

beta-ARR2
type: Protein
entity reference: beta-ARR2
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 sa65 290
feature: ACTIVE 23
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

uniprot K7BYT0 57
type: UnificationXref
id: K7BYT0
db: uniprot

PTHR24355:SF15
type: RelationshipXref
id: PTHR24355:SF15
db: PANTHER Family
relationship type: By Homology

uniprot E2RBX1 259
type: UnificationXref
id: E2RBX1
db: uniprot

PTHR24355:SF17
type: RelationshipXref
id: PTHR24355:SF17
db: PANTHER Family
relationship type: By Homology

PTHR24355:SF18
type: RelationshipXref
id: PTHR24355:SF18
db: PANTHER Family
relationship type: By Homology

ARRB2 isoform 2
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot H2QBY1 12
organism: Pan troglodytes

uniprot Q9NQ66 197
type: UnificationXref
id: Q9NQ66
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 145
xref: PTHR19850:SF28
organism: Ornithorhynchus anatinus

AT1 R s32 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AT1-R
stoichiometric coefficient: 1.0

Gqalpha
type: Protein
entity reference: Gqalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa7 304
feature: Gqalpha s16 sa7 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re19 336
type: Stoichiometry
physical entity: MAPK
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot Q6PH57 169
organism: Danio rerio

Beta-adrenergic receptor kinase 2
type: ProteinReference
xref: uniprot P26818 272
xref: PTHR24355:SF17
organism: Bos taurus

Beta-adrenergic receptor kinase 1
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot P26817 280
organism: Rattus norvegicus

uniprot P50150 114
type: UnificationXref
id: P50150
db: uniprot

PARTICIPANT STOICHIOMETRY re19 337
type: Stoichiometry
physical entity: MAPK
stoichiometric coefficient: 1.0

uniprot P29754 28
type: UnificationXref
id: P29754
db: uniprot

beta-ARR1
type: Protein
entity reference: beta-ARR1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot Q14573 218
xref: PTHR13715:SF51
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q14571 217
xref: PTHR13715:SF53
organism: Homo sapiens

uniprot O70293 255
type: UnificationXref
id: O70293
db: uniprot

uniprot P08046 174
type: UnificationXref
id: P08046
db: uniprot

uniprot F1P1X4 205
type: UnificationXref
id: F1P1X4
db: uniprot

uniprot Q5BJ11 167
type: UnificationXref
id: Q5BJ11
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q5ZIF0 66
organism: Gallus gallus

uniprot P11017 154
type: UnificationXref
id: P11017
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36507 61
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36506 60
organism: Rattus norvegicus

beta-ARR1
type: Protein
entity reference: beta-ARR1
feature: ACTIVE 23
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

IDA
type: EvidenceCodeVocabulary

PiP2
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P26632 177
type: UnificationXref
id: P26632
db: uniprot

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot E2RT75 183
xref: PTHR10336:SF10
organism: Canis lupus familiaris

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__CRAC-RIGHT__CRAC-_re14
controller: Ca2+

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: PTHR19850:SF36
xref: uniprot F7EBE7 146
organism: Xenopus tropicalis

uniprot F7G1K7 43
type: UnificationXref
id: F7G1K7
db: uniprot

GRK3
type: Protein
entity reference: GRK3
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot F6V461 96
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P16520 155
organism: Homo sapiens

PTHR24355:SF27
type: RelationshipXref
id: PTHR24355:SF27
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9NQ66 197
xref: PTHR10336:SF12
organism: Homo sapiens

uniprot F7GI54 103
type: UnificationXref
id: F7GI54
db: uniprot

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

PTHR24355:SF22
type: RelationshipXref
id: PTHR24355:SF22
db: PANTHER Family
relationship type: By Homology

uniprot P05625 80
type: UnificationXref
id: P05625
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q63932 67
organism: Mus musculus

G protein-coupled receptor kinase 5
type: ProteinReference
xref: PTHR24355:SF27
xref: uniprot Q8VEB1 266
organism: Mus musculus

uniprot P62871 160
type: UnificationXref
id: P62871
db: uniprot

uniprot P50153 116
type: UnificationXref
id: P50153
db: uniprot

beta-ARR1
type: ProteinReference
xref: P05925
standard name: beta-arrestin 1
comment: ENTITY_REFERENCE_NOTES=Long Name: beta-arrestin 1 Synonym: ARB1,ARRB1 Accession: P05925
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC._beta__minus_ARR1
member entity reference: Beta-arrestin-1
member entity reference: Arrestin, beta 1
member entity reference: Arrestin beta 1
member entity reference: ARRB1 isoform 1

PTHR45816:SF3
type: RelationshipXref
id: PTHR45816:SF3
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re20 385
type: Stoichiometry
physical entity: ELK1
stoichiometric coefficient: 1.0

uniprot P52287 157
type: UnificationXref
id: P52287
db: uniprot

PARTICIPANT STOICHIOMETRY re20 384
type: Stoichiometry
physical entity: ELK1
stoichiometric coefficient: 1.0

uniprot E1BKE7 202
type: UnificationXref
id: E1BKE7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot F7FXA9 147
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 156
xref: PTHR19850:SF28
organism: Mus musculus

uniprot P63077 121
type: UnificationXref
id: P63077
db: uniprot

Gqalpha s29 sa18 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 363
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 362
left: IP3R
interaction type: STATE_TRANSITION
right: IP3R

Gnb2 protein
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot Q5BJ11 167
organism: Danio rerio

uniprot Q14571 217
type: UnificationXref
id: Q14571
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot H2QLZ4 210
xref: PTHR13715:SF53
organism: Pan troglodytes

uniprot F7DA21 260
type: UnificationXref
id: F7DA21
db: uniprot

endosome
type: CellularLocationVocabulary
xref: GO GO:0005768 2

DISSOCIATION_LEFT__AngII_AT1_R_G_protein_complex-RIGHT__AngII_AT1_R_complex-_Gqalpha-_Gbetagamma-_re4
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 345
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 344
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 342
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 343
left: AngII/AT1-R G protein complex
interaction type: DISSOCIATION
right: Gbetagamma
right: AngII/AT1-R complex
right: Gqalpha

STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 330
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 329
left: PLC
interaction type: STATE_TRANSITION
right: PLC

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot H2QSU0 211
xref: PTHR13715:SF51
organism: Pan troglodytes

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa13 314
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Raf1 s88 sa67 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.927988476219284
comment: MODIFICATION_RESIDUE_NAME=

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 168
xref: PTHR19850:SF31
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot H9ZA60 187
organism: Macaca mulatta

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot Q63269 220
xref: PTHR13715:SF51
organism: Rattus norvegicus

Rho-related GTP-binding protein RhoA-D
type: ProteinReference
xref: uniprot Q6DHE8 249
xref: PTHR24072:SF329
organism: Danio rerio

uniprot Q803H5 170
type: UnificationXref
id: Q803H5
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q9Z329 221
xref: PTHR13715:SF53
organism: Mus musculus

STATE_TRANSITION_LEFT__EGR-RIGHT__EGR-_re29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 370
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 369
left: EGR
interaction type: STATE_TRANSITION
right: EGR

Raf1 s72 sa53 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.927988476219284
comment: MODIFICATION_RESIDUE_NAME=

uniprot K6ZCJ5 45
type: UnificationXref
id: K6ZCJ5
db: uniprot

AGT isoform 1
type: ProteinReference
xref: uniprot K7D4U3 226
organism: Pan troglodytes

ELK1 s77 sa60 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.86
comment: MODIFICATION_RESIDUE_NAME=

AT1 R s96 sa64 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AT1-R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 381
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 380
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

uniprot Q1HG70 65
type: UnificationXref
id: Q1HG70
db: uniprot

uniprot Q3UYH7 274
type: UnificationXref
id: Q3UYH7
db: uniprot

Arrestin beta 2
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot E2QUH6 6
organism: Canis lupus familiaris

uniprot Q91YI4 21
type: UnificationXref
id: Q91YI4
db: uniprot

ncbitaxon 8364 49
type: UnificationXref
id: 8364
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 129
xref: PTHR13809:SF8
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot Q61017 130
organism: Mus musculus

MEK s74 sa55 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot A5PKD6 135
type: UnificationXref
id: A5PKD6
db: uniprot

AT1 R s38 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AT1-R
stoichiometric coefficient: 1.0

uniprot H2QUY0 107
type: UnificationXref
id: H2QUY0
db: uniprot

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q66JE6 68
organism: Xenopus tropicalis

uniprot Q02750 63
type: UnificationXref
id: Q02750
db: uniprot

STATE_TRANSITION_LEFT__ELK1-RIGHT__ELK1-_re20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 385
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 384
left: ELK1
interaction type: STATE_TRANSITION
right: ELK1

uniprot E2QUH6 6
type: UnificationXref
id: E2QUH6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZCW7 208
xref: PTHR13715:SF53
organism: Monodelphis domestica

uniprot P63085 242
type: UnificationXref
id: P63085
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot E1BP29 252
xref: PTHR24355:SF15
organism: Bos taurus

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 49

uniprot P63086 243
type: UnificationXref
id: P63086
db: uniprot

Beta-adrenergic receptor kinase 2
type: ProteinReference
xref: uniprot P35626 273
xref: PTHR24355:SF17
organism: Homo sapiens

AT1 R s22 sa1 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q9XT09 69
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re7 331
type: Stoichiometry
physical entity: AngII/AT1-R complex
stoichiometric coefficient: 1.0

P05933
type: UnificationXref
id: P05933
db: PANTHER Pathway Component

P05934
type: UnificationXref
id: P05934
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re7 333
type: Stoichiometry
physical entity: AT1-R
stoichiometric coefficient: 1.0

P05935
type: UnificationXref
id: P05935
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re7 332
type: Stoichiometry
physical entity: AngII
stoichiometric coefficient: 1.0

TRIGGER
type: RelationshipTypeVocabulary

P05937
type: UnificationXref
id: P05937
db: PANTHER Pathway Component

uniprot P43249 264
type: UnificationXref
id: P43249
db: uniprot

P05938
type: UnificationXref
id: P05938
db: PANTHER Pathway Component

P05939
type: UnificationXref
id: P05939
db: PANTHER Pathway Component

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F1PL90 184
organism: Canis lupus familiaris

uniprot Q9CXP8 131
type: UnificationXref
id: Q9CXP8
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 110
xref: PTHR13809:SF28
organism: Homo sapiens

Raf1
type: Protein
entity reference: Raf1
feature: Raf1 s72 sa53 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__GRK2-RIGHT__GRK2-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 335
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 334
left: GRK2
interaction type: STATE_TRANSITION
right: GRK2

STATE_TRANSITION_LEFT__GRK3-RIGHT__GRK3-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 338
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 339
left: GRK3
interaction type: STATE_TRANSITION
right: GRK3

uniprot F7E427 145
type: UnificationXref
id: F7E427
db: uniprot

P05941
type: UnificationXref
id: P05941
db: PANTHER Pathway Component

P05940
type: UnificationXref
id: P05940
db: PANTHER Pathway Component

uniprot A0A1D5QXI6 275
type: UnificationXref
id: A0A1D5QXI6
db: uniprot

P05943
type: UnificationXref
id: P05943
db: PANTHER Pathway Component

Gqalpha s10 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gqalpha
stoichiometric coefficient: 1.0

P05942
type: UnificationXref
id: P05942
db: PANTHER Pathway Component

P05928
type: UnificationXref
id: P05928
db: PANTHER Pathway Component

P05929
type: UnificationXref
id: P05929
db: PANTHER Pathway Component

P05926
type: UnificationXref
id: P05926
db: PANTHER Pathway Component

P05927
type: UnificationXref
id: P05927
db: PANTHER Pathway Component

P05924
type: UnificationXref
id: P05924
db: PANTHER Pathway Component

P05925
type: UnificationXref
id: P05925
db: PANTHER Pathway Component

P05923
type: UnificationXref
id: P05923
db: PANTHER Pathway Component

uniprot H2Q1D9 105
type: UnificationXref
id: H2Q1D9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 154
xref: PTHR19850:SF27
organism: Bos taurus

GRK5
type: ProteinReference
xref: P05940
standard name: G protein-coupled receptor kinase 5
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.GRK5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: G protein-coupled receptor kinase 5 Synonym: Synonym not specified Accession: P05940
member entity reference: G protein-coupled receptor kinase
member entity reference: G protein-coupled receptor kinase 5

ncbitaxon 9258 97
type: UnificationXref
id: 9258
db: ncbitaxon

Gqalpha
type: ProteinReference
xref: P05927
standard name: G-protein, alpha q subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.Gq_alpha_
comment: ENTITY_REFERENCE_NOTES=Long Name: G-protein, alpha q subunit Synonym: Synonym not specified Accession: P05927
member entity reference: Guanine nucleotide-binding protein G(q) subunit alpha
member entity reference: G protein subunit alpha q
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein (G protein), q polypeptide

ELK1
type: Protein
entity reference: ELK1
feature: ELK1 s79 sa61 rs1
feature: ACTIVE 23
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

P05932
type: UnificationXref
id: P05932
db: PANTHER Pathway Component

P05931
type: UnificationXref
id: P05931
db: PANTHER Pathway Component

P05930
type: UnificationXref
id: P05930
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 149
xref: PTHR19850:SF36
organism: Macaca mulatta

uniprot F7DT22 261
type: UnificationXref
id: F7DT22
db: uniprot

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot J9P5W6 56
organism: Canis lupus familiaris

MAP2K1 protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q0VD16 64
organism: Bos taurus

uniprot P10687 191
type: UnificationXref
id: P10687
db: uniprot

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 4

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QUY0 107
xref: PTHR13809:SF1
organism: Pan troglodytes

uniprot P27361 240
type: UnificationXref
id: P27361
db: uniprot

DISSOCIATION_LEFT__PiP2-RIGHT__IP3-_DAG-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 365
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 366
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 364
left: PiP2
interaction type: DISSOCIATION
right: IP3
right: DAG

AT1 R s22 sa1 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot P43425 113
organism: Rattus norvegicus

Early growth response protein 1
type: ProteinReference
xref: uniprot P08046 174
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot A4IGZ2 86
organism: Xenopus tropicalis

MAP2K2 isoform 1
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot K7BYT0 57
organism: Pan troglodytes

uniprot P01019 228
type: UnificationXref
id: P01019
db: uniprot

AT1 R s85 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AT1-R
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf1-RIGHT__Raf1-_re23
controller: b-ArrAT1aR

uniprot E2RMC0 203
type: UnificationXref
id: E2RMC0
db: uniprot

uniprot H2R3A6 152
type: UnificationXref
id: H2R3A6
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF18
xref: uniprot A0A2R8QPB8 267
organism: Danio rerio

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot P31938 58
organism: Mus musculus

b-ArrAT1aR
type: Complex
component stoichiometry: AT1 R s96 sa64 STOICHIOMETRY ID COMPLEX
component stoichiometry: beta ARR2 s97 sa65 STOICHIOMETRY ID COMPLEX
component: beta-ARR2
component: AT1-R
feature: COMPLEX BINDING FEATURE s87 csa6 287
feature: COMPLEX BINDING FEATURE s87 csa6 289
feature: ACTIVE 23
cellular location: endosome

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot E2RMC0 203
xref: PTHR13715:SF51
organism: Canis lupus familiaris

uniprot A0A2I3TUD1 133
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot F6XWE8 98
organism: Monodelphis domestica

PTHR13809:SF19
type: RelationshipXref
id: PTHR13809:SF19
db: PANTHER Family
relationship type: By Homology

PLC
type: Protein
entity reference: PLC
feature: ACTIVE 23
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF17
xref: uniprot K7B2K4 271
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VQP7 207
xref: PTHR13715:SF52
organism: Monodelphis domestica

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot P70227 216
xref: PTHR13715:SF51
organism: Mus musculus

PKC
type: Protein
entity reference: PKC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAPK
type: Protein
entity reference: MAPK
feature: MAPK s76 sa58 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot F7HT93 270
xref: PTHR24355:SF17
organism: Macaca mulatta

PTHR13809:SF11
type: RelationshipXref
id: PTHR13809:SF11
db: PANTHER Family
relationship type: By Homology

uniprot E1B8P9 231
type: UnificationXref
id: E1B8P9
db: uniprot

uniprot P29067 14
type: UnificationXref
id: P29067
db: uniprot

EGR
type: Protein
entity reference: EGR
feature: ACTIVE 23
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot O89040 190
type: UnificationXref
id: O89040
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR45816:SF3
xref: uniprot A0A3Q1N7P8 200
organism: Bos taurus

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF27
xref: uniprot K7BG59 262
organism: Pan troglodytes

uniprot K7B2K4 271
type: UnificationXref
id: K7B2K4
db: uniprot

AT1 R s32 sa4 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P11859 229
type: UnificationXref
id: P11859
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 231
organism: Bos taurus

uniprot Q5E9F0 128
type: UnificationXref
id: Q5E9F0
db: uniprot

uniprot F7G7I9 102
type: UnificationXref
id: F7G7I9
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 18

uniprot P35626 273
type: UnificationXref
id: P35626
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 97

CRAC
type: Protein
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

PTHR13809:SF28
type: RelationshipXref
id: PTHR13809:SF28
db: PANTHER Family
relationship type: By Homology

uniprot P31938 58
type: UnificationXref
id: P31938
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 106
xref: PTHR13809:SF11
organism: Pan troglodytes

GRK3
type: Protein
entity reference: GRK3
feature: ACTIVE 23
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot H2Q482 277
organism: Pan troglodytes

PTHR13809:SF21
type: RelationshipXref
id: PTHR13809:SF21
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot P10894 192
organism: Bos taurus

AT1 R s32 sa4 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

uniprot P21279 46
type: UnificationXref
id: P21279
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot O89040 190
xref: PTHR10336:SF10
organism: Rattus norvegicus

PANTHER Pathway P05911 1
type: UnificationXref
id: P05911
db: PANTHER Pathway

ncbitaxon 9606 20
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot F6ZKL2 186
type: UnificationXref
id: F6ZKL2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot P30671 112
organism: Bos taurus

AngII s37 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AngII
stoichiometric coefficient: 1.0

uniprot Q28HZ4 248
type: UnificationXref
id: Q28HZ4
db: uniprot

uniprot Q99JE6 196
type: UnificationXref
id: Q99JE6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E823 233
xref: PTHR24055:SF203
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A818 209
xref: PTHR13715:SF53
organism: Macaca mulatta

eco ECO:0000245 16
type: UnificationXref
id: ECO:0000245
db: eco

AT1-R
type: Protein
entity reference: AT1-R
feature: AT1 R s22 sa1 rs1
feature: AT1 R s22 sa1 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa1 310
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Rho-related GTP-binding protein RhoA-B
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q6DHM9 250
organism: Danio rerio

uniprot E1C795 88
type: UnificationXref
id: E1C795
db: uniprot

uniprot K7BA21 189
type: UnificationXref
id: K7BA21
db: uniprot

Early growth response protein 1
type: ProteinReference
xref: uniprot P18146 176
organism: Homo sapiens

uniprot E1BA29 42
type: UnificationXref
id: E1BA29
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 7

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot A0A3Q1NGS8 134
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot H2QNS5 151
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot F7G7I9 102
organism: Ornithorhynchus anatinus

AngII/AT1-R complex
type: Complex
component stoichiometry: AngII s37 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: AT1 R s38 sa24 STOICHIOMETRY ID COMPLEX
component: AT1-R
component: AngII
feature: COMPLEX BINDING FEATURE s36 csa5 295
feature: COMPLEX BINDING FEATURE s36 csa5 297
cellular location: cytosol

uniprot H2QBY1 12
type: UnificationXref
id: H2QBY1
db: uniprot

uniprot H2QLB4 237
type: UnificationXref
id: H2QLB4
db: uniprot

PARTICIPANT STOICHIOMETRY re11 366
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

uniprot Q0VD16 64
type: UnificationXref
id: Q0VD16
db: uniprot

uniprot F7FHD1 236
type: UnificationXref
id: F7FHD1
db: uniprot

PARTICIPANT STOICHIOMETRY re11 365
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

uniprot F7FJJ0 173
type: UnificationXref
id: F7FJJ0
db: uniprot

PARTICIPANT STOICHIOMETRY re11 364
type: Stoichiometry
physical entity: PiP2
stoichiometric coefficient: 1.0

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 32

PLC
type: Protein
entity reference: PLC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gbetagamma
type: Complex
component stoichiometry: Ggamma s28 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s27 sa20 STOICHIOMETRY ID COMPLEX
component: Gbeta
component: Ggamma
feature: ACTIVE 23
feature: COMPLEX BINDING FEATURE s26 csa4 301
feature: COMPLEX BINDING FEATURE s26 csa4 299
cellular location: cytosol

PTHR11792:SF20
type: RelationshipXref
id: PTHR11792:SF20
db: PANTHER Family
relationship type: By Homology

Beta-adrenergic receptor kinase 2
type: ProteinReference
xref: PTHR24355:SF17
xref: uniprot Q3UYH7 274
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re2 355
type: Stoichiometry
physical entity: AT1R/G protein complex
stoichiometric coefficient: 1.0

PTHR11792:SF22
type: RelationshipXref
id: PTHR11792:SF22
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re2 354
type: Stoichiometry
physical entity: AT1-R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 353
type: Stoichiometry
physical entity: G protein
stoichiometric coefficient: 1.0

uniprot Q9XT09 69
type: UnificationXref
id: Q9XT09
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
type: ProteinReference
xref: uniprot H9FU38 212
xref: PTHR13715:SF52
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PiP2-RIGHT__IP3-_DAG-_re11
controller: PLC

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot F7GI54 103
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P21279 46
organism: Mus musculus

uniprot P17870 37
type: UnificationXref
id: P17870
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 234
organism: Xenopus tropicalis

ncbitaxon 10090 22
type: UnificationXref
id: 10090
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R973 24
organism: Macaca mulatta

uniprot P08154 175
type: UnificationXref
id: P08154
db: uniprot

uniprot F6UHL5 10
type: UnificationXref
id: F6UHL5
db: uniprot

GRK6
type: Protein
entity reference: GRK6
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P21708 239
type: UnificationXref
id: P21708
db: uniprot

PARTICIPANT STOICHIOMETRY re13 360
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 361
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

G protein-coupled receptor kinase 5
type: ProteinReference
xref: PTHR24355:SF27
xref: uniprot Q62833 265
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_re25
controller: MEK

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot Q28FH0 48
organism: Xenopus tropicalis

uniprot P16520 155
type: UnificationXref
id: P16520
db: uniprot

PARTICIPANT STOICHIOMETRY re29 370
type: Stoichiometry
physical entity: EGR
stoichiometric coefficient: 1.0

uniprot Q63932 67
type: UnificationXref
id: Q63932
db: uniprot

uniprot Q5ZIF0 66
type: UnificationXref
id: Q5ZIF0
db: uniprot

MAPK s78 sa59 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 140
xref: PTHR19850:SF29
organism: Monodelphis domestica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__beta_ARR2-RIGHT__beta_ARR2-_re10
controller: AT1-R

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

uniprot F7DR73 269
type: UnificationXref
id: F7DR73
db: uniprot

Beta-arrestin-1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot P49407 39
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 141
xref: PTHR19850:SF27
organism: Monodelphis domestica

uniprot P63216 125
type: UnificationXref
id: P63216
db: uniprot

uniprot F7A818 209
type: UnificationXref
id: F7A818
db: uniprot

uniprot F6X9W7 253
type: UnificationXref
id: F6X9W7
db: uniprot

PARTICIPANT STOICHIOMETRY re29 369
type: Stoichiometry
physical entity: EGR
stoichiometric coefficient: 1.0

uniprot F7CS91 246
type: UnificationXref
id: F7CS91
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_re19
controller: MEK

uniprot P61953 119
type: UnificationXref
id: P61953
db: uniprot

uniprot P26817 280
type: UnificationXref
id: P26817
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UD13 201
xref: PTHR13715:SF52
organism: Gallus gallus

uniprot F1NYZ2 53
type: UnificationXref
id: F1NYZ2
db: uniprot

AngII
type: Protein
entity reference: AngII
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa3 318
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q61016 129
type: UnificationXref
id: Q61016
db: uniprot

Gqalpha
type: Protein
entity reference: Gqalpha
feature: Gqalpha s10 sa11 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa11 312
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P26818 272
type: UnificationXref
id: P26818
db: uniprot

uniprot P63214 123
type: UnificationXref
id: P63214
db: uniprot

AT1-R
type: Protein
entity reference: AT1-R
feature: AT1 R s96 sa64 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 sa64 288
feature: AT1 R s96 sa64 rs1
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

Protein kinase C
type: ProteinReference
xref: uniprot A0A1D5R985 282
xref: PTHR24356:SF193
organism: Macaca mulatta

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 23
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot F7CXD0 144
organism: Monodelphis domestica

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot E2RBX1 259
xref: PTHR24355:SF27
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 357
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 356
left: Ca2+
interaction type: STATE_TRANSITION
right: Ca2+

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot Q5F3B5 50
organism: Gallus gallus

STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 361
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 360
left: Ca2+
interaction type: STATE_TRANSITION
right: Ca2+

uniprot O14610 110
type: UnificationXref
id: O14610
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 93
xref: PTHR13809:SF19
organism: Bos taurus

uniprot F6PGC8 139
type: UnificationXref
id: F6PGC8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RLH2 245
xref: PTHR24072:SF153
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_re18
controller: Raf1

uniprot P61954 120
type: UnificationXref
id: P61954
db: uniprot

uniprot P11881 213
type: UnificationXref
id: P11881
db: uniprot

uniprot P11345 81
type: UnificationXref
id: P11345
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot A0A1D5QKD3 51
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 100
xref: PTHR13809:SF8
organism: Macaca mulatta

uniprot Q6PH57 169
type: UnificationXref
id: Q6PH57
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GRK2-RIGHT__GRK2-_re6
controller: Gbetagamma

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 170
xref: PTHR19850:SF29
organism: Danio rerio

uniprot P19419 223
type: UnificationXref
id: P19419
db: uniprot

uniprot P50151 115
type: UnificationXref
id: P50151
db: uniprot

ELK1
type: ProteinReference
xref: P05934
standard name: ELK-1 member of EST oncogene family
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.ELK1
comment: ENTITY_REFERENCE_NOTES=Long Name: ELK-1 member of EST oncogene family Synonym: Synonym not specified Accession: P05934
member entity reference: ETS domain-containing protein Elk-1

uniprot Q9Z1B3 198
type: UnificationXref
id: Q9Z1B3
db: uniprot

uniprot Q9UK08 132
type: UnificationXref
id: Q9UK08
db: uniprot

AT1-R
type: Protein
entity reference: AT1-R
feature: AT1 R s38 sa24 rs2
feature: ACTIVE 23
feature: AT1 R s38 sa24 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa24 298
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A4GTP4 222
type: UnificationXref
id: A4GTP4
db: uniprot

PARTICIPANT STOICHIOMETRY re26 376
type: Stoichiometry
physical entity: AT1-R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 375
type: Stoichiometry
physical entity: beta-ARR2
stoichiometric coefficient: 1.0

uniprot P04049 78
type: UnificationXref
id: P04049
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re8
controller: Gqalpha

uniprot A3KGF7 182
type: UnificationXref
id: A3KGF7
db: uniprot

Raf1
type: Protein
entity reference: Raf1
feature: ACTIVE 23
feature: Raf1 s73 sa54 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re26 377
type: Stoichiometry
physical entity: b-ArrAT1aR
stoichiometric coefficient: 1.0

uniprot F7CXD0 144
type: UnificationXref
id: F7CXD0
db: uniprot

PTHR24072:SF329
type: RelationshipXref
id: PTHR24072:SF329
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF6
xref: uniprot Q3KRE3 126
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re3 348
type: Stoichiometry
physical entity: AngII
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 349
type: Stoichiometry
physical entity: AT1R/G protein complex
stoichiometric coefficient: 1.0

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa12 324
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 138
xref: PTHR19850:SF36
organism: Canis lupus familiaris

MEK s90 sa69 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot P62874 163
type: UnificationXref
id: P62874
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF18
xref: uniprot F7C5A3 268
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot O60262 111
organism: Homo sapiens

uniprot A4IGZ2 86
type: UnificationXref
id: A4IGZ2
db: uniprot

STATE_TRANSITION_LEFT__Raf1-RIGHT__Raf1-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 347
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 346
left: Raf1
interaction type: STATE_TRANSITION
right: Raf1

beta-ARR2
type: Protein
entity reference: beta-ARR2
feature: ACTIVE 23
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ACTIVE 23
type: EntityFeature
comment: Active state

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot H2QLZ4 210
type: UnificationXref
id: H2QLZ4
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re12
controller: IP3

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 87
xref: PTHR13809:SF28
organism: Rattus norvegicus

uniprot P29755 29
type: UnificationXref
id: P29755
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__EGR-RIGHT__EGR-_re29
control type: ACTIVATION
controller: ELK1

uniprot Q8BWG8 40
type: UnificationXref
id: Q8BWG8
db: uniprot

STATE_TRANSITION_LEFT__Raf1-RIGHT__Raf1-_re23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 382
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 383
left: Raf1
interaction type: STATE_TRANSITION
right: Raf1

uniprot Q99MK8 281
type: UnificationXref
id: Q99MK8
db: uniprot

PARTICIPANT STOICHIOMETRY re27 374
type: Stoichiometry
physical entity: b-ArrAT1aR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re27 373
type: Stoichiometry
physical entity: b-ArrAT1aR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 343
type: Stoichiometry
physical entity: AngII/AT1-R complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 342
type: Stoichiometry
physical entity: AngII/AT1-R G protein complex
stoichiometric coefficient: 1.0

uniprot Q63269 220
type: UnificationXref
id: Q63269
db: uniprot

PARTICIPANT STOICHIOMETRY re4 345
type: Stoichiometry
physical entity: Gbetagamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 344
type: Stoichiometry
physical entity: Gqalpha
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7FHD1 236
xref: PTHR24055:SF203
organism: Monodelphis domestica

Arrestin, beta 1
type: ProteinReference
xref: uniprot C3PTE8 33
xref: PTHR11792:SF22
organism: Danio rerio

uniprot P62873 162
type: UnificationXref
id: P62873
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_re24
controller: Raf1

uniprot K7D4U3 226
type: UnificationXref
id: K7D4U3
db: uniprot

beta-ARR2
type: ProteinReference
xref: P05923
standard name: beta-arrestin 2
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC._beta__minus_ARR2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: beta-arrestin 2 Synonym: ARB2,ARRB2 Accession: P05923
member entity reference: Beta-arrestin-2
member entity reference: Uncharacterized protein
member entity reference: Arrestin beta 2
member entity reference: ARRB2 isoform 2

uniprot H2Q3W7 106
type: UnificationXref
id: H2Q3W7
db: uniprot

uniprot P50154 117
type: UnificationXref
id: P50154
db: uniprot

AT1 R s96 sa64 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

uniprot F6TLR3 225
type: UnificationXref
id: F6TLR3
db: uniprot

AT1-R
type: Protein
entity reference: AT1-R
feature: AT1 R s51 sa32 rs1
feature: AT1 R s51 sa32 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION
type: InteractionVocabulary

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF27
xref: uniprot E1BQG4 258
organism: Gallus gallus

uniprot F7H6T7 149
type: UnificationXref
id: F7H6T7
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: MEK s89 sa68 rs1
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

G protein-coupled receptor kinase
type: ProteinReference
xref: uniprot F7DR73 269
xref: PTHR24355:SF17
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re3 350
type: Stoichiometry
physical entity: AngII/AT1-R G protein complex
stoichiometric coefficient: 1.0

uniprot Q63844 244
type: UnificationXref
id: Q63844
db: uniprot

Beta-arrestin-2
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot P32121 19
organism: Homo sapiens

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 84
xref: uniprot Q99N57 83
xref: PTHR44329:SF22
organism: Mus musculus

GNB4 protein
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot A5PKD6 135
organism: Bos taurus

Beta-arrestin-2
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot P32120 17
organism: Bos taurus

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P19419 223
organism: Homo sapiens

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 20

uniprot D3ZLD6 87
type: UnificationXref
id: D3ZLD6
db: uniprot

uniprot F6VQP7 207
type: UnificationXref
id: F6VQP7
db: uniprot

uniprot F7HT93 270
type: UnificationXref
id: F7HT93
db: uniprot

ncbitaxon 9913 18
type: UnificationXref
id: 9913
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re18 340
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F1MX21 204
organism: Bos taurus

PTHR24072:SF153
type: RelationshipXref
id: PTHR24072:SF153
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re18 341
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q1HG70 65
organism: Canis lupus familiaris

ELK1 s79 sa61 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.86
comment: MODIFICATION_RESIDUE_NAME=

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 88
xref: PTHR13809:SF6
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 101
xref: PTHR13809:SF19
organism: Macaca mulatta

G protein
type: Complex
component stoichiometry: Ggamma s15 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s14 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gqalpha s16 sa7 STOICHIOMETRY ID COMPLEX
component: Ggamma
component: Gqalpha
component: Gbeta
feature: COMPLEX BINDING FEATURE s13 csa2 307
feature: COMPLEX BINDING FEATURE s13 csa2 305
feature: COMPLEX BINDING FEATURE s13 csa2 303
cellular location: cytosol

CRAC
type: Protein
feature: ACTIVE 23
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

MEK s75 sa57 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

TRANSPORT_LEFT__b_ArrAT1aR-RIGHT__b_ArrAT1aR-_re27
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 374
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 373
left: b-ArrAT1aR
interaction type: TRANSPORT
right: b-ArrAT1aR

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot B8JLJ7 41
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot G3V8K2 104
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot F7CS91 246
organism: Monodelphis domestica

AT1 R s96 sa64 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

GO GO:0005783 4
type: UnificationXref
id: GO:0005783
db: GO

uniprot Q9HAV0 171
type: UnificationXref
id: Q9HAV0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F6S9S9 54
organism: Monodelphis domestica

Gqalpha s33 sa10 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot P63078 122
type: UnificationXref
id: P63078
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot A0A1D5QUZ8 230
organism: Macaca mulatta

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF27
xref: uniprot F7DT22 261
organism: Macaca mulatta

uniprot E1BW98 136
type: UnificationXref
id: E1BW98
db: uniprot

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

uniprot F7BRK5 77
type: UnificationXref
id: F7BRK5
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot A0A2J8QDF6 181
organism: Pan troglodytes

RhoA
type: Protein
entity reference: RhoA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q6DHE8 249
type: UnificationXref
id: Q6DHE8
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: ACTIVE 23
feature: MEK s90 sa69 rs1
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

uniprot P62879 164
type: UnificationXref
id: P62879
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

GO GO:0005634 3
type: UnificationXref
id: GO:0005634
db: GO

uniprot Q9Z329 221
type: UnificationXref
id: Q9Z329
db: uniprot

uniprot E2RBP5 172
type: UnificationXref
id: E2RBP5
db: uniprot

uniprot F6ZCW7 208
type: UnificationXref
id: F6ZCW7
db: uniprot

Transforming protein RhoA
type: ProteinReference
xref: uniprot Q9QUI0 251
xref: PTHR24072:SF153
organism: Mus musculus

uniprot Q61017 130
type: UnificationXref
id: Q61017
db: uniprot

uniprot P17252 285
type: UnificationXref
id: P17252
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61954 120
xref: PTHR13809:SF1
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot K7E376 109
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61952 118
xref: PTHR13809:SF1
organism: Homo sapiens

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot A0A3S5ZPX3 52
xref: PTHR48013:SF8
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot J9JHK9 188
xref: PTHR10336:SF11
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot P61953 119
xref: PTHR13809:SF1
organism: Mus musculus

Gqalpha
type: Protein
entity reference: Gqalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa10 322
feature: Gqalpha s33 sa10 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAPK
type: Protein
entity reference: MAPK
feature: MAPK s92 sa71 rs1
feature: ACTIVE 23
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

uniprot K7E376 109
type: UnificationXref
id: K7E376
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10687 191
xref: PTHR10336:SF12
organism: Rattus norvegicus

uniprot Q01986 62
type: UnificationXref
id: Q01986
db: uniprot

uniprot F6SD46 185
type: UnificationXref
id: F6SD46
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot F6ZIZ9 142
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QLB4 237
xref: PTHR24055:SF203
organism: Pan troglodytes

uniprot O14775 153
type: UnificationXref
id: O14775
db: uniprot

ncbitaxon 13616 44
type: UnificationXref
id: 13616
db: ncbitaxon

Gqalpha
type: Protein
entity reference: Gqalpha
feature: ACTIVE 23
feature: Gqalpha s29 sa18 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TLR3 225
organism: Macaca mulatta

uniprot E2RJB3 92
type: UnificationXref
id: E2RJB3
db: uniprot

Early growth response protein
type: ProteinReference
xref: uniprot F7FJJ0 173
organism: Macaca mulatta

uniprot F1PQM2 35
type: UnificationXref
id: F1PQM2
db: uniprot

uniprot Q14643 219
type: UnificationXref
id: Q14643
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RhoA-RIGHT__RhoA-_re28
controller: Gqalpha

uniprot F7FY59 254
type: UnificationXref
id: F7FY59
db: uniprot

AT1 R s38 sa24 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.26

AngII
type: Protein
entity reference: AngII
comment: SPECIES_TYPE=PROTEIN

Gbeta s34 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

G protein-coupled receptor kinase 6
type: ProteinReference
xref: PTHR24355:SF15
xref: uniprot P43250 256
organism: Homo sapiens

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P17252 285
xref: PTHR24356:SF193
organism: Homo sapiens

uniprot P25098 279
type: UnificationXref
id: P25098
db: uniprot

GRK2
type: Protein
entity reference: GRK2
feature: ACTIVE 23
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein subunit beta 3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot H2R3A6 152
organism: Pan troglodytes

RhoA
type: Protein
entity reference: RhoA
feature: ACTIVE 23
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein-coupled receptor kinase 5
type: ProteinReference
xref: PTHR24355:SF27
xref: uniprot P43249 264
organism: Bos taurus

uniprot P54313 159
type: UnificationXref
id: P54313
db: uniprot

MEK s89 sa68 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot J9JHK9 188
type: UnificationXref
id: J9JHK9
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

HETERODIMER_ASSOCIATION_LEFT__AngII-_AT1R_G_protein_complex-RIGHT__AngII_AT1_R_G_protein_complex-_re3
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 349
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 348
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 350
left: AT1R/G protein complex
left: AngII
interaction type: HETERODIMER_ASSOCIATION
right: AngII/AT1-R G protein complex

uniprot A4IFL6 85
type: UnificationXref
id: A4IFL6
db: uniprot

PTHR24072:SF100
type: RelationshipXref
id: PTHR24072:SF100
db: PANTHER Family
relationship type: By Homology

Beta-adrenergic receptor kinase 1
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot Q99MK8 281
organism: Mus musculus

uniprot F7G3J2 148
type: UnificationXref
id: F7G3J2
db: uniprot

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

uniprot P29066 38
type: UnificationXref
id: P29066
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot A0A1D5Q4D0 179
organism: Macaca mulatta

uniprot K7BG59 262
type: UnificationXref
id: K7BG59
db: uniprot

uniprot E2R9G5 90
type: UnificationXref
id: E2R9G5
db: uniprot

uniprot P18146 176
type: UnificationXref
id: P18146
db: uniprot

AngII/AT1-R G protein complex
type: Complex
component stoichiometry: AT1 R s32 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s34 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s35 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gqalpha s33 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: AngII s31 sa3 STOICHIOMETRY ID COMPLEX
component: Ggamma
component: AngII
component: AT1-R
component: Gbeta
component: Gqalpha
feature: COMPLEX BINDING FEATURE s42 csa1 325
feature: COMPLEX BINDING FEATURE s42 csa1 321
feature: COMPLEX BINDING FEATURE s42 csa1 319
feature: COMPLEX BINDING FEATURE s42 csa1 317
feature: COMPLEX BINDING FEATURE s42 csa1 323
cellular location: cytosol

PKC
type: ProteinReference
xref: P05942
standard name: protein kinase C
comment: ENTITY_REFERENCE_NOTES=Long Name: protein kinase C Synonym: Synonym not specified Accession: P05942
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.PKC
member entity reference: Protein kinase C
member entity reference: Protein kinase C alpha type

uniprot F6ZIZ9 142
type: UnificationXref
id: F6ZIZ9
db: uniprot

G protein-coupled receptor kinase
type: ProteinReference
xref: PTHR24355:SF22
xref: uniprot A0A1D5QXI6 275
organism: Macaca mulatta

uniprot Q01970 195
type: UnificationXref
id: Q01970
db: uniprot

uniprot P62881 166
type: UnificationXref
id: P62881
db: uniprot

uniprot H2Q9G5 150
type: UnificationXref
id: H2Q9G5
db: uniprot

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 5

beta-ARR2
type: Protein
entity reference: beta-ARR2
feature: ACTIVE 23
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 sa74 294
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Arrestin beta 1
type: ProteinReference
xref: PTHR11792:SF22
xref: uniprot F1PQM2 35
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GRK3-RIGHT__GRK3-_re5
controller: Gbetagamma

PARTICIPANT STOICHIOMETRY re15 356
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 357
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot P43425 113
type: UnificationXref
id: P43425
db: uniprot

Gbeta
type: ProteinReference
xref: P05930
standard name: G-protein, beta subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.G_beta_
comment: ENTITY_REFERENCE_NOTES= Long Name: G-protein, beta subunit Synonym: Guanine nucleotide-binding protein, beta subunit Accession: P05930
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Uncharacterized protein
member entity reference: G protein subunit beta 5
member entity reference: Gnb2 protein
member entity reference: G protein subunit beta 1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: G protein subunit beta 3
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: GNB4 protein
member entity reference: G protein subunit beta 2
member entity reference: Gnb1l protein

Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re13
pathway component: STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_re25
pathway component: STATE_TRANSITION_LEFT__RhoA-RIGHT__RhoA-_re28
pathway component: HETERODIMER_ASSOCIATION_LEFT__beta_ARR2-_AT1_R-RIGHT__b_ArrAT1aR-_re26
pathway component: STATE_TRANSITION_LEFT__GRK2-RIGHT__GRK2-_re6
pathway component: STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_re19
pathway component: STATE_TRANSITION_LEFT__ELK1-RIGHT__ELK1-_re20
pathway component: STATE_TRANSITION_LEFT__Raf1-RIGHT__Raf1-_re17
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re15
pathway component: STATE_TRANSITION_LEFT__Raf1-RIGHT__Raf1-_re23
pathway component: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re8
pathway component: STATE_TRANSITION_LEFT__beta_ARR1-RIGHT__beta_ARR1-_re9
pathway component: STATE_TRANSITION_LEFT__EGR-RIGHT__EGR-_re29
pathway component: STATE_TRANSITION_LEFT__beta_ARR2-RIGHT__beta_ARR2-_re10
pathway component: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re12
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_re18
pathway component: STATE_TRANSITION_LEFT__CRAC-RIGHT__CRAC-_re14
pathway component: STATE_TRANSITION_LEFT__GRK3-RIGHT__GRK3-_re5
pathway component: HETERODIMER_ASSOCIATION_LEFT__G_protein-_AT1_R-RIGHT__AT1R_G_protein_complex-_re2
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_re24
pathway component: DISSOCIATION_LEFT__AngII_AT1_R_complex-RIGHT__AngII-_AT1_R-_re7
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re16
pathway component: DISSOCIATION_LEFT__AngII_AT1_R_G_protein_complex-RIGHT__AngII_AT1_R_complex-_Gqalpha-_Gbetagamma-_re4
pathway component: HETERODIMER_ASSOCIATION_LEFT__AngII-_AT1R_G_protein_complex-RIGHT__AngII_AT1_R_G_protein_complex-_re3
pathway component: DISSOCIATION_LEFT__PiP2-RIGHT__IP3-_DAG-_re11
pathway component: TRANSPORT_LEFT__b_ArrAT1aR-RIGHT__b_ArrAT1aR-_re27
xref: PANTHER Pathway P05911 1
comment: MODEL_NOTES=Panther Pathway: P05911 The angiotensin 1a receptor mediates various angiotensin II (AngII)-dependent physiological responses such as vasoconstriction, smooth muscle cell motility and growth, and aldosterone secretion. By employing HEK-293 cells as a model system and utilizing b-arrestin and heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptor kinase (GRK) RNAi technology, various novel aspects of angiotensin type II 1a receptor (AT1aR)-mediated extracellular signal-regulated protein kinase (ERK) activation have been uncovered. Stimulation of the receptor with its peptide ligand AngII results in the activation of Gaq/11 and the downstream kinase protein kinase C (PKC). This leads to the activation of the ERK cascade. The time course of this G protein-dependent ERK activation is rapid and transient, and the active ERK translocates to the nucleus to stimulate transcriptional pathways governed by Elk-1 activity and early growth response I (EGR-1) induction. The G protein-dependent ERK activation is not sensitive to b-arrestin RNAi and is eliminated by the addition of chemical inhibitors of PKC such as Ro-31-8425. The AngII-stimulated ERK pathway has an additional component that remains active for prolonged periods and is insensitive to PKC inhibitors. This pool of ERK is completely sensitive to b-arrestin 2 siRNA and remains excluded from the nucleus. b-arrestin 2-complexed ERK is targeted to endosomal compartments, where it presumably phosphorylates cytosolic substrates. Quite interestingly, b-arrestin 2-dependent ERK activation occurs only when b-arrestin 2 is recruited to GRK5- and/or GRK6- phosphorylated receptors. Depletion of cellular GRK5 or GRK6 isoforms results in complete inhibition of b-arrestin 2-dependent ERK activation, whereas depletion of the other GRK isoforms (GRK2 and 3) does not affect b-arrestin 2-dependent pERK, or rather even increases it. However, GRK2/3 are the primary kinases responsible for the bulk of re…

GRK2
type: ProteinReference
xref: P05943
standard name: G protein-coupled receptor kinase 2
comment: ENTITY_REFERENCE_NOTES=Long Name: G protein-coupled receptor kinase 2 Synonym: ADRBK1,BARK1,beta-ARK1,beta-adrenergic receptor kinase 1 Accession: P05943
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin.PROTEIN.GENERIC.GRK2
member entity reference: Beta-adrenergic receptor kinase 1
member entity reference: G protein-coupled receptor kinase

MAPK s91 sa70 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.56

uniprot H2RA86 238
type: UnificationXref
id: H2RA86
db: uniprot

uniprot A0A1D5R985 282
type: UnificationXref
id: A0A1D5R985
db: uniprot

uniprot P97711 257
type: UnificationXref
id: P97711
db: uniprot

uniprot K7AE17 108
type: UnificationXref
id: K7AE17
db: uniprot

IP3
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

G protein-coupled receptor kinase 5
type: ProteinReference
xref: PTHR24355:SF27
xref: uniprot P34947 263
organism: Homo sapiens