Cyclic AMP-dependent transcription factor ATF-1
type: ProteinReference
xref: PTHR45879:SF2
xref: uniprot Q08DA8 484
organism: Bos taurus

PTHR11961:SF12
type: RelationshipXref
id: PTHR11961:SF12
db: PANTHER Family
relationship type: By Homology

uniprot Q9S9N1 841
type: UnificationXref
id: Q9S9N1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Fos_c_Jun_-RIGHT__Complex__Fos_c_Jun_-_r75
controller: JNK

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r86
controller: Complex (FAS/DAXX/ FADD/FAS ligand)

PTHR11961:SF15
type: RelationshipXref
id: PTHR11961:SF15
db: PANTHER Family
relationship type: By Homology

FAS protein
type: ProteinReference
xref: PTHR46874:SF1
xref: uniprot A5D7R0 346
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q2F6 435
organism: Macaca mulatta

Caspase 8
type: ProteinReference
xref: P00299
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Caspase 8
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase 8 Synonym: Cysteinyl aspartic acid-protease-8 Accession: P00299
member entity reference: Uncharacterized protein
member entity reference: Caspase 8, apoptosis-related cysteine peptidase
member entity reference: Caspase-8
member entity reference: CASP8 isoform 11

uniprot P10417 197
type: UnificationXref
id: P10417
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FEI6 95
xref: PTHR10044:SF79
organism: Macaca mulatta

uniprot F7DC98 754
type: UnificationXref
id: F7DC98
db: uniprot

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r117 1005
type: Stoichiometry
physical entity: ELF2alpha
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GCK-RIGHT__GCK-_r21
controller: Complex (TRADD/RAIDD/ TRAF2/RIP)

Transcription factor p65
type: ProteinReference
xref: uniprot Q04207 406
organism: Mus musculus

ncbitaxon 5664 816
type: UnificationXref
id: 5664
db: ncbitaxon

Transcription factor p65
type: ProteinReference
xref: uniprot Q04206 405
xref: PTHR24169:SF1
organism: Homo sapiens

uniprot E2RIE0 443
type: UnificationXref
id: E2RIE0
db: uniprot

ncbitaxon 188937 538
type: UnificationXref
id: 188937
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r117 1006
type: Stoichiometry
physical entity: ELF2alpha
stoichiometric coefficient: 1.0

Tumor necrosis factor receptor superfamily member 6
type: ProteinReference
xref: PTHR46874:SF1
xref: uniprot Q63199 349
organism: Rattus norvegicus

uniprot Q39026 176
type: UnificationXref
id: Q39026
db: uniprot

uniprot E2RML9 354
type: UnificationXref
id: E2RML9
db: uniprot

Caspase-9
type: ProteinReference
xref: uniprot P55211 415
xref: PTHR10454:SF157
organism: Homo sapiens

Caspase-7
type: ProteinReference
xref: uniprot P55210 429
xref: PTHR10454:SF31
organism: Homo sapiens

Activating transcription factor 6 beta
type: ProteinReference
xref: uniprot Q4G097 486
xref: PTHR46164:SF2
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r97 1098
type: Stoichiometry
physical entity: Complex (Bcl-2/Bik)
stoichiometric coefficient: 1.0

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot P55213 512
organism: Rattus norvegicus

uniprot Q9VG58 842
type: UnificationXref
id: Q9VG58
db: uniprot

PARTICIPANT STOICHIOMETRY r97 1096
type: Stoichiometry
physical entity: Bcl-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r97 1097
type: Stoichiometry
physical entity: Bik
stoichiometric coefficient: 1.0

PTHR11961:SF29
type: RelationshipXref
id: PTHR11961:SF29
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF210
xref: uniprot L7N050 766
organism: Canis lupus familiaris

uniprot Q9MBD8 276
type: UnificationXref
id: Q9MBD8
db: uniprot

Mediator of RNA polymerase II transcription subunit 37a
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q9LKR3 840
organism: Arabidopsis thaliana

Mus musculus
type: BioSource
xref: ncbitaxon 10090 20

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_7-RIGHT__Caspase_7-_r51
controller: Caspase 8

Tumor necrosis factor ligand superfamily member 6
type: ProteinReference
xref: uniprot P41047 890
xref: PTHR11471:SF33
organism: Mus musculus

uniprot P53349 364
type: UnificationXref
id: P53349
db: uniprot

intracellular
type: CellularLocationVocabulary
xref: GO GO:0005622 3

uniprot Q0P538 310
type: UnificationXref
id: Q0P538
db: uniprot

Tumor necrosis factor receptor superfamily member 1A
type: ProteinReference
xref: uniprot P22934 341
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r120 997
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r120 998
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

DAXX
type: Protein
entity reference: DAXX
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot E2RQB6 287
type: UnificationXref
id: E2RQB6
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P28482 166
organism: Homo sapiens

ncbitaxon 9031 16
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot A0A1D5R985 658
type: UnificationXref
id: A0A1D5R985
db: uniprot

uniprot Q03963 369
type: UnificationXref
id: Q03963
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PXS7 148
xref: PTHR24055:SF393
organism: Canis lupus familiaris

uniprot P11146 783
type: UnificationXref
id: P11146
db: uniprot

Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
type: ProteinReference
xref: uniprot P97287 549
organism: Mus musculus

uniprot F1N1U0 446
type: UnificationXref
id: F1N1U0
db: uniprot

uniprot H2QLQ7 465
type: UnificationXref
id: H2QLQ7
db: uniprot

FAS-associated death domain protein
type: ProteinReference
xref: PTHR15077:SF9
xref: uniprot Q8R2E7 896
organism: Rattus norvegicus

uniprot P50591 92
type: UnificationXref
id: P50591
db: uniprot

Cyclic AMP-dependent transcription factor ATF-7
type: ProteinReference
xref: PTHR19304:SF10
xref: uniprot A0A1D5RIQ9 436
organism: Macaca mulatta

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 163
organism: Homo sapiens

TRADD s3 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRADD
stoichiometric coefficient: 1.0

uniprot P20029 792
type: UnificationXref
id: P20029
db: uniprot

uniprot Q01233 808
type: UnificationXref
id: Q01233
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 193

uniprot F6WMM9 748
type: UnificationXref
id: F6WMM9
db: uniprot

uniprot H2Q0M2 888
type: UnificationXref
id: H2Q0M2
db: uniprot

Probable mediator of RNA polymerase II transcription subunit 37e
type: ProteinReference
xref: uniprot P22953 795
xref: PTHR19375:SF413
organism: Arabidopsis thaliana

TRANSPORT_LEFT__endoG-RIGHT__endoG-_r35
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1095
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 1094
left: endoG
interaction type: TRANSPORT
right: endoG

uniprot F6QKL0 742
type: UnificationXref
id: F6QKL0
db: uniprot

uniprot Q9D2C7 274
type: UnificationXref
id: Q9D2C7
db: uniprot

PANTHER Pathway P00006 1
type: UnificationXref
id: P00006
db: PANTHER Pathway

STATE_TRANSITION_LEFT__Caspase_7-RIGHT__Caspase_7-_r106
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r106 1039
participant stoichiometry: PARTICIPANT STOICHIOMETRY r106 1040
left: Caspase 7
interaction type: STATE_TRANSITION
right: Caspase 7

STATE_TRANSITION_LEFT__Bid-RIGHT__Bid-_r28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 969
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 970
left: Bid
interaction type: STATE_TRANSITION
right: Bid

uniprot P09225 35
type: UnificationXref
id: P09225
db: uniprot

uniprot Q04206 405
type: UnificationXref
id: Q04206
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QK27 413
xref: PTHR10454:SF157
organism: Macaca mulatta

uniprot A0A2I3TFE7 371
type: UnificationXref
id: A0A2I3TFE7
db: uniprot

uniprot Q8C3Q9 416
type: UnificationXref
id: Q8C3Q9
db: uniprot

PTHR24356:SF347
type: RelationshipXref
id: PTHR24356:SF347
db: PANTHER Family
relationship type: By Homology

PTHR47386:SF1
type: RelationshipXref
id: PTHR47386:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q4V8C7 297
type: UnificationXref
id: Q4V8C7
db: uniprot

…
type: Stoichiometry
physical entity: TNFR2
stoichiometric coefficient: 3.0

FAS ligand
type: Protein
entity reference: FAS ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa32 952
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Heat shock 70 kDa protein 1B
type: ProteinReference
xref: PTHR19375:SF223
xref: uniprot P17879 790
organism: Mus musculus

uniprot P16474 786
type: UnificationXref
id: P16474
db: uniprot

uniprot Q91974 359
type: UnificationXref
id: Q91974
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q9Z1L0 597
xref: PTHR10048:SF33
organism: Rattus norvegicus

uniprot H2QW14 712
type: UnificationXref
id: H2QW14
db: uniprot

uniprot O88996 644
type: UnificationXref
id: O88996
db: uniprot

uniprot Q9U3L3 250
type: UnificationXref
id: Q9U3L3
db: uniprot

uniprot P27361 163
type: UnificationXref
id: P27361
db: uniprot

Bcl-2 homologous antagonist/killer
type: ProteinReference
xref: PTHR11256:SF41
xref: uniprot Q16611 255
organism: Homo sapiens

uniprot P36604 801
type: UnificationXref
id: P36604
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10454:SF8
xref: uniprot F7DGQ2 315
organism: Macaca mulatta

IkappaB
type: Protein
entity reference: IkappaB
feature: IkappaB s95 a118 rs1
feature: IkappaB s95 a118 rs2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Cytochrome c, somatic
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot Q640U4 874
organism: Xenopus tropicalis

Bcl-2-related ovarian killer protein
type: ProteinReference
xref: PTHR11256:SF48
xref: uniprot Q792S6 87
organism: Rattus norvegicus

Bag
type: Protein
entity reference: Bag
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Map2k3 protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot B1H230 630
organism: Rattus norvegicus

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

Diablo IAP-binding mitochondrial protein
type: ProteinReference
xref: uniprot A1DZY5 552
organism: Canis lupus familiaris

Protein kinase C-like 1B
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot P34885 693
organism: Caenorhabditis elegans

Cyclic AMP-dependent transcription factor ATF-6 alpha
type: ProteinReference
xref: uniprot G3V909 461
xref: PTHR46164:SF1
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9U3L3 250
organism: Caenorhabditis elegans

uniprot F7BIC2 670
type: UnificationXref
id: F7BIC2
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Bax_Bak_-RIGHT__Bax-_Bak-_r96
controller: Bim

ncbitaxon 243232 532
type: UnificationXref
id: 243232
db: ncbitaxon

RELA proto-oncogene, NF-kB subunit
type: ProteinReference
xref: uniprot F1PCU1 392
xref: PTHR24169:SF1
organism: Canis lupus familiaris

uniprot P55061 270
type: UnificationXref
id: P55061
db: uniprot

Cyclic AMP-dependent transcription factor ATF-4
type: ProteinReference
xref: uniprot Q9ES19 493
xref: PTHR13044:SF2
organism: Rattus norvegicus

uniprot P05771 683
type: UnificationXref
id: P05771
db: uniprot

Stress-activated protein kinase jnk-1
type: ProteinReference
xref: PTHR24055:SF341
xref: uniprot Q8WQG9 247
organism: Caenorhabditis elegans

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot E2RKR0 615
organism: Canis lupus familiaris

CASP7 isoform 1
type: ProteinReference
xref: PTHR10454:SF31
xref: uniprot A0A2I3SBZ3 426
organism: Pan troglodytes

uniprot P91634 593
type: UnificationXref
id: P91634
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q2TY19 224
xref: PTHR24055:SF222
organism: Gallus gallus

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q5Z859 180
xref: PTHR24055:SF196
organism: Oryza sativa

uniprot Q9WUL6 882
type: UnificationXref
id: Q9WUL6
db: uniprot

PARTICIPANT STOICHIOMETRY r64 1051
type: Stoichiometry
physical entity: Complex (IkappaB/NFkappaB)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 1038
type: Stoichiometry
physical entity: ASK1
stoichiometric coefficient: 1.0

ncbitaxon 3055 188
type: UnificationXref
id: 3055
db: ncbitaxon

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E7EXT6 52
xref: PTHR24356:SF190
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r64 1050
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 1037
type: Stoichiometry
physical entity: ASK1
stoichiometric coefficient: 1.0

BAG3 isoform 1
type: ProteinReference
xref: uniprot H2Q2N9 281
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10602:SF0
xref: uniprot F6RU41 522
organism: Monodelphis domestica

ncbitaxon 178306 540
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot P78560 373
type: UnificationXref
id: P78560
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7DUD6 573
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot A0A3Q1MNG1 629
organism: Bos taurus

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

Heat shock protein SSA3
type: ProteinReference
xref: uniprot P09435 772
xref: PTHR19375:SF385
organism: Saccharomyces cerevisiae

TNF receptor superfamily member 1B
type: ProteinReference
xref: uniprot K7BTC1 332
xref: PTHR47386:SF1
organism: Pan troglodytes

uniprot F7EI91 652
type: UnificationXref
id: F7EI91
db: uniprot

Heat shock 70 kDa protein cognate 2
type: ProteinReference
xref: PTHR19375:SF388
xref: uniprot P11146 783
organism: Drosophila melanogaster

Heat shock 70 kDa protein cognate 4
type: ProteinReference
xref: uniprot P11147 784
xref: PTHR19375:SF457
organism: Drosophila melanogaster

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 57
organism: Monodelphis domestica

Jun dimerization protein 2
type: ProteinReference
xref: uniprot Q8WYK2 491
organism: Homo sapiens

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot P11142 782
organism: Homo sapiens

AGAP004581-PA
type: ProteinReference
xref: uniprot A7UT42 717
xref: PTHR19375:SF371
organism: Anopheles gambiae

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot P16474 786
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r64 1049
type: Stoichiometry
physical entity: NFkappaB
stoichiometric coefficient: 1.0

Complex (TNFR2/TNF)
type: Complex
component stoichiometry: TNF s249 sa29 STOICHIOMETRY ID COMPLEX
component: TNF
component: TNFR2
feature: COMPLEX BINDING FEATURE s208 a333 903
feature: COMPLEX BINDING FEATURE s208 a333 901
feature: ACTIVE 25
cellular location: intracellular

uniprot Q07820 550
type: UnificationXref
id: Q07820
db: uniprot

Flip
type: ProteinReference
xref: P00284
standard name: FLICE inhibitory protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Flip
comment: ENTITY_REFERENCE_NOTES=Long Name: FLICE inhibitory protein Synonym: CFLAR,Casp8- and FADD-like apoptosis regulator,I-FLICE,Inhibitor of FLICE Accession: P00284
member entity reference: Uncharacterized protein
member entity reference: CASP8 and FADD-like apoptosis regulator

PTHR46861:SF1
type: RelationshipXref
id: PTHR46861:SF1
db: PANTHER Family
relationship type: By Homology

FAS ligand
type: Protein
entity reference: FAS ligand
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q63844 181
xref: PTHR24055:SF393
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R3L5 381
xref: PTHR24169:SF1
organism: Macaca mulatta

uniprot Q91Y86 248
type: UnificationXref
id: Q91Y86
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24169:SF21
xref: uniprot F7GVU6 396
organism: Macaca mulatta

MODULATION
type: Control
xref: MODULATION
controlled: Pro-apoptotic
controller: ATF

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P79734 218
organism: Danio rerio

uniprot H9EU76 603
type: UnificationXref
id: H9EU76
db: uniprot

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot G3V926 619
organism: Rattus norvegicus

ncbitaxon 8364 62
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot A9TWR9 728
type: UnificationXref
id: A9TWR9
db: uniprot

uniprot Q78E65 488
type: UnificationXref
id: Q78E65
db: uniprot

Eukaryotic translation initiation factor 2 subunit alpha
type: ProteinReference
xref: uniprot E2RL17 521
xref: PTHR10602:SF0
organism: Canis lupus familiaris

uniprot Q53RJ5 818
type: UnificationXref
id: Q53RJ5
db: uniprot

TNF receptor superfamily member 10d
type: ProteinReference
xref: PTHR46330:SF4
xref: uniprot H2QVW0 260
organism: Pan troglodytes

uniprot F6XP81 61
type: UnificationXref
id: F6XP81
db: uniprot

uniprot P70677 513
type: UnificationXref
id: P70677
db: uniprot

PARTICIPANT STOICHIOMETRY r35 1094
type: Stoichiometry
physical entity: endoG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r95 1104
type: Stoichiometry
physical entity: Complex (Bax/Bak)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 1095
type: Stoichiometry
physical entity: endoG
stoichiometric coefficient: 1.0

uniprot A0A0U5J5G6 90
type: UnificationXref
id: A0A0U5J5G6
db: uniprot

PARTICIPANT STOICHIOMETRY r131 1113
type: Stoichiometry
physical entity: Complex (FAS/DAXX/ FADD/FAS ligand)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BK67 114
xref: PTHR13008:SF7
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r131 1112
type: Stoichiometry
physical entity: Complex (FAS/FAS ligand)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 999
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r131 1111
type: Stoichiometry
physical entity: DAXX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r131 1110
type: Stoichiometry
physical entity: FADD
stoichiometric coefficient: 1.0

c Jun s15 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase FUS3
type: ProteinReference
xref: uniprot P16892 161
xref: PTHR24055:SF158
organism: Saccharomyces cerevisiae

PTHR46874:SF1
type: RelationshipXref
id: PTHR46874:SF1
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5PFJ6 715
type: UnificationXref
id: A0A1D5PFJ6
db: uniprot

NFKB2 isoform 3
type: ProteinReference
xref: PTHR24169:SF21
xref: uniprot A0A2I3RN76 383
organism: Pan troglodytes

RIPK1 isoform 1
type: ProteinReference
xref: uniprot H2QS79 638
xref: PTHR44329:SF6
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r95 1102
type: Stoichiometry
physical entity: Bax
stoichiometric coefficient: 1.0

uniprot F7HC75 673
type: UnificationXref
id: F7HC75
db: uniprot

uniprot Q07816 15
type: UnificationXref
id: Q07816
db: uniprot

PARTICIPANT STOICHIOMETRY r95 1103
type: Stoichiometry
physical entity: Bak
stoichiometric coefficient: 1.0

uniprot A1DZY5 552
type: UnificationXref
id: A1DZY5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A9SNF1 727
xref: PTHR19375:SF395
organism: Physcomitrella patens

PTHR19375:SF371
type: RelationshipXref
id: PTHR19375:SF371
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3SHM4 121
type: UnificationXref
id: A0A2I3SHM4
db: uniprot

Mitogen-activated protein kinase 4
type: ProteinReference
xref: PTHR24055:SF439
xref: uniprot Q39024 175
organism: Arabidopsis thaliana

FAS
type: Complex
component stoichiometry: FAS s60 sa31 STOICHIOMETRY ID COMPLEX
component: FAS
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa31 950
cellular location: intracellular

Interferon-induced, double-stranded RNA-activated protein kinase
type: ProteinReference
xref: PTHR11042:SF163
xref: uniprot P19525 368
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r115 1012
type: Stoichiometry
physical entity: PKR
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q39027 177
xref: PTHR24055:SF401
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r115 1011
type: Stoichiometry
physical entity: PKR
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 6
type: ProteinReference
xref: PTHR24055:SF466
xref: uniprot Q39026 176
organism: Arabidopsis thaliana

uniprot Q13490 100
type: UnificationXref
id: Q13490
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF378
xref: uniprot Q39021 172
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF391
xref: uniprot Q39023 174
organism: Arabidopsis thaliana

FAS
type: Complex
component stoichiometry: FAS s62 sa33 STOICHIOMETRY ID COMPLEX
component: FAS
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa33 906
cellular location: intracellular

uniprot P82910 807
type: UnificationXref
id: P82910
db: uniprot

Mitogen-activated protein kinase 2
type: ProteinReference
xref: uniprot Q39022 173
xref: PTHR24055:SF196
organism: Arabidopsis thaliana

PTHR19375:SF379
type: RelationshipXref
id: PTHR19375:SF379
db: PANTHER Family
relationship type: By Homology

PRKRA isoform 1
type: ProteinReference
xref: uniprot H2QJ21 294
organism: Pan troglodytes

70 kDa heat shock protein
type: ProteinReference
xref: uniprot Q10NA9 810
xref: PTHR19375:SF418
organism: Oryza sativa

TNF receptor superfamily member 10c
type: ProteinReference
xref: uniprot H2QVV9 259
organism: Pan troglodytes

Bim
type: Protein
entity reference: Bim
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

00696
type: UnificationXref
id: MOD:00696
db: mod

PARTICIPANT STOICHIOMETRY r65 1045
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

X-linked inhibitor of apoptosis
type: ProteinReference
xref: uniprot F1QMW2 502
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r65 1046
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ASK1-RIGHT__ASK1-_r83
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 993
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 992
left: ASK1
interaction type: STATE_TRANSITION
right: ASK1

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2RA86 156
xref: PTHR24055:SF393
organism: Pan troglodytes

TNFR2
type: Protein
entity reference: TNFR2

uniprot F6RDI1 299
type: UnificationXref
id: F6RDI1
db: uniprot

uniprot P62897 864
type: UnificationXref
id: P62897
db: uniprot

PTHR24271:SF53
type: RelationshipXref
id: PTHR24271:SF53
db: PANTHER Family
relationship type: By Homology

cAMP response element-binding protein
type: ProteinReference
xref: uniprot Q7SX83 489
xref: PTHR45879:SF1
organism: Gallus gallus

PTHR19375:SF380
type: RelationshipXref
id: PTHR19375:SF380
db: PANTHER Family
relationship type: By Homology

uniprot F6TYR2 280
type: UnificationXref
id: F6TYR2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ELF2alpha-RIGHT__ELF2alpha-_r117
controller: Caspase 7

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 725

Tumor necrosis factor
type: ProteinReference
xref: uniprot P51742 39
xref: PTHR11471:SF23
organism: Canis lupus familiaris

uniprot Q13489 99
type: UnificationXref
id: Q13489
db: uniprot

B-cell leukemia/lymphoma 2 related protein A1b
type: ProteinReference
xref: PTHR11256:SF10
xref: uniprot Q497M6 312
organism: Mus musculus

TNFR1
type: Complex
component stoichiometry: TNFR1 s25 sa21 STOICHIOMETRY ID COMPLEX
component: TNFR1
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa21 958
cellular location: intracellular

TNFR1
type: Complex
component stoichiometry: TNFR1 s27 sa23 STOICHIOMETRY ID COMPLEX
component: TNFR1
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa23 938
cellular location: intracellular

uniprot Q5BBL8 819
type: UnificationXref
id: Q5BBL8
db: uniprot

MEKK1
type: Protein
entity reference: MEKK1
feature: MEKK1 s106 a132 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot D4A5L9 844
type: UnificationXref
id: D4A5L9
db: uniprot

uniprot Q60765 487
type: UnificationXref
id: Q60765
db: uniprot

PARTICIPANT STOICHIOMETRY r86 989
type: Stoichiometry
physical entity: Caspase 8
stoichiometric coefficient: 1.0

BAG family molecular chaperone regulator 3
type: ProteinReference
xref: uniprot Q9JLV1 285
organism: Mus musculus

…
type: Stoichiometry
physical entity: TNFR1
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY r86 988
type: Stoichiometry
physical entity: Caspase 8
stoichiometric coefficient: 1.0

uniprot P0DMV8 775
type: UnificationXref
id: P0DMV8
db: uniprot

Lymphotoxin B
type: ProteinReference
xref: uniprot Q6MG45 46
organism: Rattus norvegicus

DISSOCIATION
type: RelationshipTypeVocabulary

Tumor necrosis factor receptor superfamily member 10B
type: ProteinReference
xref: PTHR46330:SF4
xref: uniprot Q9QZM4 264
organism: Mus musculus

Bcl-w
type: ProteinReference
xref: P00316
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bcl-w
comment: ENTITY_REFERENCE_NOTES=Long Name: Bcl-w Synonym: Synonym not specified Accession: P00316
member entity reference: Bcl-2-like protein 2
member entity reference: BCL2 like 2
member entity reference: BCL2-like 2
member entity reference: Bcl-W
member entity reference: Uncharacterized protein

uniprot Q08DA8 484
type: UnificationXref
id: Q08DA8
db: uniprot

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1000
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 999
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

uniprot F6V652 747
type: UnificationXref
id: F6V652
db: uniprot

Bcl-2-like protein 2
type: ProteinReference
xref: uniprot P70345 645
xref: PTHR11256:SF13
organism: Mus musculus

Heat shock cognate 70-kd protein,-like
type: ProteinReference
xref: uniprot B0S610 730
xref: PTHR19375:SF448
organism: Danio rerio

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot K7CBH8 678
organism: Pan troglodytes

endoG
type: ProteinReference
xref: P00279
standard name: Endonuclease G
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Endonuclease G Synonym: Synonym not specified Accession: P00279
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.endoG
member entity reference: Endonuclease G
member entity reference: Uncharacterized protein
member entity reference: Endonuclease G, mitochondrial

uniprot P55211 415
type: UnificationXref
id: P55211
db: uniprot

Bax inhibitor 1
type: ProteinReference
xref: uniprot Q9VSH3 277
organism: Drosophila melanogaster

uniprot F7GAP5 577
type: UnificationXref
id: F7GAP5
db: uniprot

uniprot P24723 690
type: UnificationXref
id: P24723
db: uniprot

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

uniprot F1P630 227
type: UnificationXref
id: F1P630
db: uniprot

uniprot P15337 471
type: UnificationXref
id: P15337
db: uniprot

PARTICIPANT STOICHIOMETRY r119 1002
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r119 1001
type: Stoichiometry
physical entity: P53
stoichiometric coefficient: 1.0

uniprot E2QYK5 650
type: UnificationXref
id: E2QYK5
db: uniprot

uniprot P06804 34
type: UnificationXref
id: P06804
db: uniprot

uniprot A0A2I3T7A8 561
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

Apoptosis-inducing factor 1, mitochondrial
type: ProteinReference
xref: uniprot Q9JM53 328
xref: PTHR43557:SF4
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QS62 236
xref: PTHR24055:SF172
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r83 993
type: Stoichiometry
physical entity: ASK1
stoichiometric coefficient: 1.0

uniprot O00329 582
type: UnificationXref
id: O00329
db: uniprot

PARTICIPANT STOICHIOMETRY r83 992
type: Stoichiometry
physical entity: ASK1
stoichiometric coefficient: 1.0

TNFR2
type: Complex
component stoichiometry: TNFR2 s250 sa28 STOICHIOMETRY ID COMPLEX
component: TNFR2
feature: COMPLEX PARTICIPANT BINDING FEATURE s250 sa28 902
cellular location: intracellular

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot P19120 791
organism: Bos taurus

TNFR2
type: Complex
component stoichiometry: TNFR2 s248 sa26 STOICHIOMETRY ID COMPLEX
component: TNFR2
feature: COMPLEX PARTICIPANT BINDING FEATURE s248 sa26 944
cellular location: intracellular

Bcl-2-interacting killer
type: ProteinReference
xref: uniprot Q13323 29
xref: PTHR15018:SF1
organism: Homo sapiens

Cyclic AMP-dependent transcription factor ATF-1
type: ProteinReference
xref: uniprot P81269 480
xref: PTHR45879:SF2
organism: Mus musculus

ATF
type: ProteinReference
xref: P00302
standard name: Activating transcription factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.ATF
comment: ENTITY_REFERENCE_NOTES=Long Name: Activating transcription factor Synonym: Synonym not specified Accession: P00302
member entity reference: Jun dimerization protein 2
member entity reference: ATF7 isoform 2
member entity reference: Cyclic AMP-dependent transcription factor ATF-2
member entity reference: Cyclic AMP-dependent transcription factor ATF-3
member entity reference: cAMP responsive element binding protein 1
member entity reference: Cyclic AMP-dependent transcription factor ATF-4
member entity reference: Cyclic AMP-dependent transcription factor ATF-1
member entity reference: Activating transcription factor 2
member entity reference: cAMP-responsive element modulator
member entity reference: Cyclic AMP-dependent transcription factor ATF-7
member entity reference: Uncharacterized protein
member entity reference: Cyclic AMP-responsive element-binding protein 1
member entity reference: Cyclic AMP-dependent transcription factor ATF-6 alpha
member entity reference: Cyclic AMP-dependent transcription factor ATF-6 beta
member entity reference: cAMP-responsive element-binding protein 1
member entity reference: ATF3 isoform 2
member entity reference: Activating transcription factor 6 beta
member entity reference: cAMP response element-binding protein
member entity reference: Activating transcription factor 4 (Tax-responsive enhancer element B67)
member entity reference: Activating transcription factor 3
member entity reference: ATF6 isoform 1
member entity reference: Activating transcription factor 7
member entity reference: Cyclic AMP-dependent transcription factor ATF-3 isoform 1
member entity reference: Activating transcription factor 1
member entity reference: ATF4
member entity reference: ATF1 isoform 2

uniprot Q6MG45 46
type: UnificationXref
id: Q6MG45
db: uniprot

CASP8 and FADD-like apoptosis regulator
type: ProteinReference
xref: PTHR10454:SF8
xref: uniprot O35732 317
organism: Mus musculus

Serine/threonine-protein kinase akt-2
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q9XTG7 80
organism: Caenorhabditis elegans

uniprot Q53NM9 817
type: UnificationXref
id: Q53NM9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A4FV00 225
xref: PTHR24055:SF162
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7CYE3 234
xref: PTHR24055:SF162
organism: Xenopus tropicalis

uniprot Q14249 290
type: UnificationXref
id: Q14249
db: uniprot

BOK protein
type: ProteinReference
xref: PTHR11256:SF48
xref: uniprot A6H6W7 82
organism: Bos taurus

uniprot O08873 117
type: UnificationXref
id: O08873
db: uniprot

Cyclic AMP-responsive element-binding protein 1
type: ProteinReference
xref: PTHR45879:SF1
xref: uniprot P15337 471
organism: Rattus norvegicus

NF-kappaB transcription factor p65 subunit
type: ProteinReference
xref: uniprot A1XG22 386
xref: PTHR24169:SF1
organism: Bos taurus

uniprot A0A2J8QY32 562
type: UnificationXref
id: A0A2J8QY32
db: uniprot

uniprot F6VAN0 451
type: UnificationXref
id: F6VAN0
db: uniprot

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: uniprot P15336 470
xref: PTHR19304:SF9
organism: Homo sapiens

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot H2QW34 620
organism: Pan troglodytes

PTHR22969:SF7
type: RelationshipXref
id: PTHR22969:SF7
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot P46734 636
organism: Homo sapiens

uniprot Q8WYK2 491
type: UnificationXref
id: Q8WYK2
db: uniprot

uniprot P17325 500
type: UnificationXref
id: P17325
db: uniprot

Eukaryotic translation initiation factor 2 subunit alpha
type: ProteinReference
xref: uniprot P56286 528
organism: Schizosaccharomyces pombe

Flip
type: Protein
entity reference: Flip
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Eif2s1l protein
type: ProteinReference
xref: PTHR10602:SF0
xref: uniprot Q7ZWD3 536
organism: Danio rerio

uniprot P04657 860
type: UnificationXref
id: P04657
db: uniprot

uniprot P41047 890
type: UnificationXref
id: P41047
db: uniprot

Mitogen-activated protein kinase kinase kinase 14
type: ProteinReference
xref: uniprot D3ZTD1 878
organism: Rattus norvegicus

Protein kinase C eta type
type: ProteinReference
xref: uniprot F1MY82 666
xref: PTHR24356:SF192
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q2U4X3 50
xref: PTHR24356:SF171
organism: Gallus gallus

P53
type: ProteinReference
xref: P00273
standard name: Tumor protein p53
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.P53
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Tumor protein p53 Synonym: TP53,Transformation regulated protein 53 Accession: P00273 Pathway Link: P00033|P04497|Insulin/IGF pathway-protein kinase B signaling cascade*P04397|P04640|p53 pathway by glucose deprivation*P04398|P04668|p53 pathway feedback loops 2*P04392|P04539|P53 pathway feedback loops 1*P00059|P01485|p53 pathway
member entity reference: Cellular tumor antigen p53

uniprot F6SW23 569
type: UnificationXref
id: F6SW23
db: uniprot

Cytochrome c 2.1
type: ProteinReference
xref: uniprot P19974 861
organism: Caenorhabditis elegans

IkappaB
type: ProteinReference
xref: P00292
standard name: Inhibitor of kappa light chain gene enhancer in B cells
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Inhibitor of kappa light chain gene enhancer in B cells Synonym: Nuclear factor of kappa light chain gene enhancer in B cells inhibitor Accession: P00292
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.I_kappa_B
member entity reference: NF-kappa-B inhibitor alpha
member entity reference: NFKB inhibitor alpha
member entity reference: NF kappa B inhibitor alpha (Fragment)
member entity reference: Uncharacterized protein

uniprot P17252 687
type: UnificationXref
id: P17252
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot H2QDQ1 676
organism: Pan troglodytes

uniprot F6RA79 668
type: UnificationXref
id: F6RA79
db: uniprot

ds-RNA
type: RnaRegion
comment: SPECIES_TYPE=RNA

Bcl-2
type: ProteinReference
xref: P00270
comment: ENTITY_REFERENCE_NOTES=Long Name: Bcl-2 Synonym: B-cell Leukemia 2 Accession: P00270
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bcl-2
member entity reference: B-cell CLL/lymphoma 2
member entity reference: Apoptosis regulator Bcl-2

uniprot O95831 327
type: UnificationXref
id: O95831
db: uniprot

uniprot V5IKE7 192
type: UnificationXref
id: V5IKE7
db: uniprot

uniprot O35904 583
type: UnificationXref
id: O35904
db: uniprot

uniprot Q8WXG6 119
type: UnificationXref
id: Q8WXG6
db: uniprot

PTHR19375:SF388
type: RelationshipXref
id: PTHR19375:SF388
db: PANTHER Family
relationship type: By Homology

uniprot E2RLL2 388
type: UnificationXref
id: E2RLL2
db: uniprot

PTHR19375:SF385
type: RelationshipXref
id: PTHR19375:SF385
db: PANTHER Family
relationship type: By Homology

uniprot Q8CI61 714
type: UnificationXref
id: Q8CI61
db: uniprot

Granzyme B
type: ProteinReference
xref: PTHR24271:SF53
xref: uniprot A0A2I3TDG1 105
organism: Pan troglodytes

IGFR2
type: ProteinReference
xref: P00282
standard name: Insulin-like growth factor II receptor
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.RECEPTOR.IGFR2
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Uncharacterized protein
member entity reference: Insulin-like growth factor 2 receptor
member entity reference: Cation-independent mannose-6-phosphate receptor

uniprot G3V909 461
type: UnificationXref
id: G3V909
db: uniprot

PTHR19375:SF382
type: RelationshipXref
id: PTHR19375:SF382
db: PANTHER Family
relationship type: By Homology

PTHR19375:SF391
type: RelationshipXref
id: PTHR19375:SF391
db: PANTHER Family
relationship type: By Homology

FAS
type: ProteinReference
xref: P00289
comment: ENTITY_REFERENCE_NOTES=Long Name: FAS Synonym: APO1,APT1,Apoptosis antigen 1,CD95,TNFRSF6,Tumor necrosis factor receptor superfamily member 6 Accession: P00289
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.RECEPTOR.FAS
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Tumor necrosis factor receptor superfamily member 6
member entity reference: Fas cell surface death receptor
member entity reference: FAS protein

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XD14 452
organism: Monodelphis domestica

Activating transcription factor 3
type: ProteinReference
xref: uniprot E2RTH8 444
xref: PTHR23351:SF23
organism: Canis lupus familiaris

uniprot F6R2V4 279
type: UnificationXref
id: F6R2V4
db: uniprot

Apoptosis regulator Bcl-2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot P49950 198
organism: Rattus norvegicus

TNFR1
type: ProteinReference
xref: P00288
standard name: Tumor necrosis factor receptor 1
comment: ENTITY_REFERENCE_NOTES=Long Name: Tumor necrosis factor receptor 1 Synonym: Synonym not specified Accession: P00288
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.RECEPTOR.TNFR1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Tumor necrosis factor receptor superfamily member 1A
member entity reference: Tumor necrosis factor receptor 1

TNF receptor-associated factor 2
type: ProteinReference
xref: uniprot Q12933 519
xref: PTHR10131:SF21
organism: Homo sapiens

Cytochrome C
type: Protein
entity reference: Cytochrome C
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

MKK3
type: Protein
entity reference: MKK3
feature: ACTIVE 25
feature: MKK3 s115 a137 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r128 976
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K5T3 560
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r128 977
type: Stoichiometry
physical entity: TNFR2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r128 978
type: Stoichiometry
physical entity: Complex (TNFR2/TNF)
stoichiometric coefficient: 1.0

BAG4 isoform 1
type: ProteinReference
xref: PTHR12329:SF10
xref: uniprot H2QW14 712
organism: Pan troglodytes

JNK s113 a142 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

AIF
type: Protein
entity reference: AIF
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__TRAF2-_Complex__TNFR2_TNF_-RIGHT__Complex__TNFR2_TNF__TRAF2_-_r129
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r129 973
participant stoichiometry: PARTICIPANT STOICHIOMETRY r129 975
participant stoichiometry: PARTICIPANT STOICHIOMETRY r129 974
left: TRAF2
left: Complex (TNFR2/TNF)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TNFR2/TNF/ TRAF2)

STATE_TRANSITION_LEFT__ASK1-RIGHT__ASK1-_r67
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 1038
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 1037
left: ASK1
interaction type: STATE_TRANSITION
right: ASK1

Fos
type: Protein
entity reference: Fos
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa9 914
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot O88351 623
type: UnificationXref
id: O88351
db: uniprot

uniprot H2QJ86 421
type: UnificationXref
id: H2QJ86
db: uniprot

uniprot F1MYJ4 53
type: UnificationXref
id: F1MYJ4
db: uniprot

PTHR19375:SF395
type: RelationshipXref
id: PTHR19375:SF395
db: PANTHER Family
relationship type: By Homology

TRAF2
type: Protein
entity reference: TRAF2
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P55062 271
type: UnificationXref
id: P55062
db: uniprot

uniprot A0A0G2K5T3 560
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

uniprot H2R0G7 237
type: UnificationXref
id: H2R0G7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 153
organism: Monodelphis domestica

uniprot P34931 799
type: UnificationXref
id: P34931
db: uniprot

uniprot H3FYW1 764
type: UnificationXref
id: H3FYW1
db: uniprot

TNF receptor superfamily member 10a
type: ProteinReference
xref: uniprot A0A2I3RUZ2 257
xref: PTHR46330:SF2
organism: Pan troglodytes

MKK3 s104 a130 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P47809 112
type: UnificationXref
id: P47809
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7GEK1 63
xref: PTHR24356:SF190
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r75 1014
type: Stoichiometry
physical entity: Complex (Fos/c-Jun)
stoichiometric coefficient: 1.0

uniprot P42574 511
type: UnificationXref
id: P42574
db: uniprot

PARTICIPANT STOICHIOMETRY r75 1013
type: Stoichiometry
physical entity: Complex (Fos/c-Jun)
stoichiometric coefficient: 1.0

uniprot Q99683 211
type: UnificationXref
id: Q99683
db: uniprot

ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r105
control type: INHIBITION
controller: XIAP

uniprot P63319 695
type: UnificationXref
id: P63319
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

Heat shock protein family A (Hsp70) member 8
type: ProteinReference
xref: uniprot F6QKL0 742
xref: PTHR19375:SF379
organism: Xenopus tropicalis

uniprot Q04863 408
type: UnificationXref
id: Q04863
db: uniprot

MEKK1 s106 a132 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P18870 501
organism: Gallus gallus

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 143

uniprot Q02156 698
type: UnificationXref
id: Q02156
db: uniprot

PARTICIPANT STOICHIOMETRY r19 1000
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

AGAP000018-PA
type: ProteinReference
xref: uniprot Q7QEJ7 594
xref: PTHR10048:SF14
organism: Anopheles gambiae

uniprot Q9WTX2 298
type: UnificationXref
id: Q9WTX2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot F6RLH5 743
organism: Macaca mulatta

Predicted protein
type: ProteinReference
xref: uniprot A9TWR9 728
xref: PTHR19375:SF395
organism: Physcomitrella patens

RELB proto-oncogene, NF-kB subunit
type: ProteinReference
xref: uniprot F1MBB0 390
organism: Bos taurus

Endonuclease G, mitochondrial
type: ProteinReference
xref: uniprot O08600 289
xref: PTHR13966:SF5
organism: Mus musculus

uniprot F7CZ86 753
type: UnificationXref
id: F7CZ86
db: uniprot

uniprot F7FEI6 95
type: UnificationXref
id: F7FEI6
db: uniprot

uniprot K7D8W8 503
type: UnificationXref
id: K7D8W8
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_7-RIGHT__Caspase_7-_r106
control type: INHIBITION
controller: c-IAP1,2

uniprot P56424 216
type: UnificationXref
id: P56424
db: uniprot

uniprot A0A2I3T9Y4 48
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

SEK1
type: Protein
entity reference: SEK1
feature: SEK1 s109 a135 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot D3ZTD1 878
type: UnificationXref
id: D3ZTD1
db: uniprot

uniprot F1PXS7 148
type: UnificationXref
id: F1PXS7
db: uniprot

Bid
type: Protein
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F7FD05 457
type: UnificationXref
id: F7FD05
db: uniprot

Bcl-W
type: ProteinReference
xref: PTHR11256:SF13
xref: uniprot O88996 644
organism: Rattus norvegicus

MKK7
type: Protein
entity reference: MKK7
feature: MKK7 s111 a140 rs1
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P01101 655
type: UnificationXref
id: P01101
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK7-RIGHT__MKK7-_r71
controller: MEKK1

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 734

TRADD
type: Protein
entity reference: TRADD
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

RAIDD
type: Protein
entity reference: RAIDD
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa4 964
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q04207 406
type: UnificationXref
id: Q04207
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot F1PXD3 631
xref: PTHR48013:SF21
organism: Canis lupus familiaris

HETERODIMER_ASSOCIATION_LEFT__TNF-_TNFR1-RIGHT__Complex__TNFR1_TNF_-_r123
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r123 996
participant stoichiometry: PARTICIPANT STOICHIOMETRY r123 995
participant stoichiometry: PARTICIPANT STOICHIOMETRY r123 994
left: TNF
left: TNFR1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TNFR1/TNF)

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot O14920 621
organism: Homo sapiens

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

uniprot F4JP81 267
type: UnificationXref
id: F4JP81
db: uniprot

uniprot Q9BKU3 541
type: UnificationXref
id: Q9BKU3
db: uniprot

Tumor necrosis factor receptor superfamily member 10D
type: ProteinReference
xref: uniprot Q9UBN6 265
organism: Homo sapiens

ncbitaxon 559292 160
type: UnificationXref
id: 559292
db: ncbitaxon

ncbitaxon 9615 22
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot P55213 512
type: UnificationXref
id: P55213
db: uniprot

MAPK
type: Protein
entity reference: MAPK
feature: ACTIVE 25
feature: MAPK s114 a138 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 6239 72
type: UnificationXref
id: 6239
db: ncbitaxon

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 58

uniprot A8XHD1 721
type: UnificationXref
id: A8XHD1
db: uniprot

RIP
type: Protein
entity reference: RIP
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PKCs
type: Protein
entity reference: PKCs
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Bcl2-associated athanogene 3
type: ProteinReference
xref: uniprot Q5U2U8 283
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATF-RIGHT__ATF-_r74
controller: MAPK

Jun dimerization protein 2
type: ProteinReference
xref: uniprot Q78E65 488
organism: Rattus norvegicus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F1NG47 667
organism: Gallus gallus

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot P16951 472
organism: Mus musculus

uniprot P11142 782
type: UnificationXref
id: P11142
db: uniprot

uniprot E2RNP2 664
type: UnificationXref
id: E2RNP2
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: uniprot E2RGU7 663
xref: PTHR24356:SF192
organism: Canis lupus familiaris

…
type: Stoichiometry
physical entity: TNFR1
stoichiometric coefficient: 3.0

uniprot H2R1S6 432
type: UnificationXref
id: H2R1S6
db: uniprot

uniprot F6STW5 845
type: UnificationXref
id: F6STW5
db: uniprot

Insulin-like growth factor 2 receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot K7B5K7 301
organism: Pan troglodytes

PTHR10454:SF198
type: RelationshipXref
id: PTHR10454:SF198
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 232
xref: PTHR24055:SF222
organism: Macaca mulatta

uniprot Q6L509 821
type: UnificationXref
id: Q6L509
db: uniprot

Bcl-xS
type: ProteinReference
xref: P00323
standard name: Bcl2-related protein short isoform
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bcl-xS
comment: ENTITY_REFERENCE_NOTES=Long Name: Bcl2-related protein short isoform Synonym: Synonym not specified Accession: P00323
member entity reference: Bcl-2-like protein 1
member entity reference: Uncharacterized protein

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7G3I5 576
organism: Monodelphis domestica

PTHR24055:SF466
type: RelationshipXref
id: PTHR24055:SF466
db: PANTHER Family
relationship type: By Homology

Activating transcription factor 3
type: ProteinReference
xref: uniprot F6XKJ2 453
xref: PTHR23351:SF23
organism: Ornithorhynchus anatinus

uniprot P15307 399
type: UnificationXref
id: P15307
db: uniprot

Lymphotoxin-beta
type: ProteinReference
xref: uniprot Q5TM22 45
xref: PTHR11471:SF29
organism: Macaca mulatta

uniprot F1MD58 427
type: UnificationXref
id: F1MD58
db: uniprot

Lymphotoxin-alpha
type: ProteinReference
xref: uniprot Q5TM20 44
organism: Macaca mulatta

uniprot P68101 529
type: UnificationXref
id: P68101
db: uniprot

Cytochrome C
type: Protein
entity reference: Cytochrome C
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q16611 255
type: UnificationXref
id: Q16611
db: uniprot

ELF2alpha
type: Protein
entity reference: ELF2alpha
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r71 1030
type: Stoichiometry
physical entity: MKK7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 1035
type: Stoichiometry
physical entity: MKK3
stoichiometric coefficient: 1.0

FAS ligand s65 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAS ligand
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot E2RGP4 130
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r68 1036
type: Stoichiometry
physical entity: MKK3
stoichiometric coefficient: 1.0

uniprot P79734 218
type: UnificationXref
id: P79734
db: uniprot

Caspase 9
type: Protein
entity reference: Caspase 9
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WV79 230
xref: PTHR24055:SF172
organism: Monodelphis domestica

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot A0A3Q1LMD4 122
organism: Bos taurus

uniprot P41797 802
type: UnificationXref
id: P41797
db: uniprot

uniprot A0A0G2K344 559
type: UnificationXref
id: A0A0G2K344
db: uniprot

DISSOCIATION_LEFT__Complex__IGFR2_Granzyme_B_-RIGHT__Granzyme_B-_IGFR2-_r112
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 1023
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 1022
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 1021
left: Complex (IGFR2/Granzyme B)
interaction type: DISSOCIATION
right: IGFR2
right: Granzyme B

uniprot F7GEK1 63
type: UnificationXref
id: F7GEK1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IkappaB-RIGHT__IkappaB-_r60
controller: IKK

uniprot A0A2I3SR38 659
type: UnificationXref
id: A0A2I3SR38
db: uniprot

uniprot Q0TY36 871
type: UnificationXref
id: Q0TY36
db: uniprot

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot P78695 806
organism: Neurospora crassa

uniprot Q8CE90 613
type: UnificationXref
id: Q8CE90
db: uniprot

uniprot P00044 856
type: UnificationXref
id: P00044
db: uniprot

uniprot P25118 342
type: UnificationXref
id: P25118
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Bax_Bak_-RIGHT__Bax-_Bak-_r96
controller: Bcl-xS

STATE_TRANSITION_LEFT__Caspase_7-RIGHT__Caspase_7-_r51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1073
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 1072
left: Caspase 7
interaction type: STATE_TRANSITION
right: Caspase 7

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot D3ZHL6 127
organism: Rattus norvegicus

Caspase 9
type: Protein
entity reference: Caspase 9
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

GH01161p
type: ProteinReference
xref: uniprot Q9W3I9 520
organism: Drosophila melanogaster

Diablo homolog, mitochondrial
type: ProteinReference
xref: uniprot Q9JIQ3 556
organism: Mus musculus

Cyclic AMP-dependent transcription factor ATF-1
type: ProteinReference
xref: PTHR45879:SF2
xref: uniprot P18846 474
organism: Homo sapiens

Cyclic AMP-dependent transcription factor ATF-3
type: ProteinReference
xref: PTHR23351:SF23
xref: uniprot P18847 475
organism: Homo sapiens

Cyclic AMP-dependent transcription factor ATF-4
type: ProteinReference
xref: uniprot P18848 476
xref: PTHR13044:SF2
organism: Homo sapiens

PKCs
type: Protein
entity reference: PKCs
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ASK1-RIGHT__ASK1-_r83
controller: Complex (TNFR1/TNF/ MADD)

Bcl-xS
type: Protein
entity reference: Bcl-xS
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Caspase 10
type: Protein
entity reference: Caspase 10
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q8F2 674
type: UnificationXref
id: H2Q8F2
db: uniprot

uniprot G7N5L8 338
type: UnificationXref
id: G7N5L8
db: uniprot

uniprot P05129 681
type: UnificationXref
id: P05129
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r113
controller: Granzyme B

Heat shock protein/chaperone
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot B8BWB9 731
organism: Thalassiosira pseudonana

uniprot F7C587 420
type: UnificationXref
id: F7C587
db: uniprot

Caspase 7
type: Protein
entity reference: Caspase 7
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q4B6 893
type: UnificationXref
id: H2Q4B6
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 158

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKR-RIGHT__PKR-_r115
controller: PACT

uniprot Q8IVH8 607
type: UnificationXref
id: Q8IVH8
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot A0A3Q1NH21 49
organism: Bos taurus

Apoptotic protease-activating factor 1
type: ProteinReference
xref: uniprot F1MUW4 430
xref: PTHR22845:SF5
organism: Bos taurus

uniprot A0A2I3RN76 383
type: UnificationXref
id: A0A2I3RN76
db: uniprot

Nuclear factor kappa B subunit 2
type: ProteinReference
xref: uniprot Q5U2Z4 410
xref: PTHR24169:SF21
organism: Rattus norvegicus

Cyclic AMP-dependent transcription factor ATF-6 alpha
type: ProteinReference
xref: uniprot P18850 477
xref: PTHR46164:SF1
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7GAP5 577
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P21708 162
xref: PTHR24055:SF393
organism: Rattus norvegicus

PTHR15077:SF9
type: RelationshipXref
id: PTHR15077:SF9
db: PANTHER Family
relationship type: By Homology

Heat shock cognate 70 kDa protein 2, putative, expressed
type: ProteinReference
xref: PTHR19375:SF417
xref: uniprot Q84TA1 828
organism: Oryza sativa

uniprot P31749 66
type: UnificationXref
id: P31749
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P47809 112
organism: Mus musculus

Mediator of RNA polymerase II transcription subunit 37f
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q39043 814
organism: Arabidopsis thaliana

uniprot F6WWG3 706
type: UnificationXref
id: F6WWG3
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot Q13233 365
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r70 1032
type: Stoichiometry
physical entity: MEKK1
stoichiometric coefficient: 1.0

uniprot O00220 261
type: UnificationXref
id: O00220
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r58
controller: PKCs

PARTICIPANT STOICHIOMETRY r70 1031
type: Stoichiometry
physical entity: MEKK1
stoichiometric coefficient: 1.0

Caspase-8
type: ProteinReference
xref: uniprot O89110 422
xref: PTHR10454:SF162
organism: Mus musculus

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot F6SHC1 617
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O00329 582
xref: PTHR10048:SF35
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r71 1029
type: Stoichiometry
physical entity: MKK7
stoichiometric coefficient: 1.0

uniprot H2QK53 9
type: UnificationXref
id: H2QK53
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V652 747
xref: PTHR19375:SF382
organism: Monodelphis domestica

Danio rerio
type: BioSource
xref: ncbitaxon 7955 24

uniprot E2RGP4 130
type: UnificationXref
id: E2RGP4
db: uniprot

ELF2alpha
type: Protein
entity reference: ELF2alpha
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Endonuclease G
type: ProteinReference
xref: uniprot Q7JXB9 292
organism: Drosophila melanogaster

PTHR24055:SF438
type: RelationshipXref
id: PTHR24055:SF438
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF439
type: RelationshipXref
id: PTHR24055:SF439
db: PANTHER Family
relationship type: By Homology

Cyclic AMP-dependent transcription factor ATF-3
type: ProteinReference
xref: PTHR23351:SF23
xref: uniprot A0A452DID2 440
organism: Bos taurus

B-cell CLL/lymphoma 2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot H2QEM8 194
organism: Pan troglodytes

Interferon-inducible double-stranded RNA-dependent protein kinase activator A
type: ProteinReference
xref: uniprot O75569 295
organism: Homo sapiens

TRANSPORT_LEFT__Cytochrome_C-RIGHT__Cytochrome_C-_r26
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 971
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 972
left: Cytochrome C
interaction type: TRANSPORT
right: Cytochrome C

Heat shock 70 kDa protein A
type: ProteinReference
xref: uniprot P09446 773
xref: PTHR19375:SF457
organism: Caenorhabditis elegans

TRANSPORT_LEFT__Smac_Diablo-RIGHT__Smac_Diablo-_r37
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1091
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 1090
left: Smac/Diablo
interaction type: TRANSPORT
right: Smac/Diablo

GCK
type: Protein
entity reference: GCK
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Heat shock protein 5
type: ProteinReference
xref: uniprot Q6P3L3 822
xref: PTHR19375:SF144
organism: Danio rerio

TRAIL-R
type: Protein
entity reference: TRAIL-R
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa13 926
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F7DD51 755
type: UnificationXref
id: F7DD51
db: uniprot

ASK1
type: ProteinReference
xref: P00272
standard name: Apoptosis signal-regulating kinase-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Apoptosis signal-regulating kinase-1 Synonym: MAP kinase kinase kinase 5,MAPKKK5,MEKK5,Mitogen activated protein kinase kinase kinase 5 Accession: P00272
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.ASK1
member entity reference: Mitogen-activated protein kinase kinase kinase 5
member entity reference: Uncharacterized protein
member entity reference: MAP3K5 isoform 1

PTHR10454:SF157
type: RelationshipXref
id: PTHR10454:SF157
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5RIQ9 436
type: UnificationXref
id: A0A1D5RIQ9
db: uniprot

uniprot P14659 785
type: UnificationXref
id: P14659
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r90
controller: Caspase 8

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GWD0 269
organism: Macaca mulatta

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 139

NFKB2 protein
type: ProteinReference
xref: PTHR24169:SF21
xref: uniprot A7MBB7 387
organism: Bos taurus

Caspase-8
type: ProteinReference
xref: PTHR10454:SF162
xref: uniprot Q14790 423
organism: Homo sapiens

uniprot P18870 501
type: UnificationXref
id: P18870
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot D4A5Q1 564
xref: PTHR10048:SF35
organism: Rattus norvegicus

PTHR46680:SF1
type: RelationshipXref
id: PTHR46680:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F7EAF8 331
type: UnificationXref
id: F7EAF8
db: uniprot

uniprot F6QP11 57
type: UnificationXref
id: F6QP11
db: uniprot

uniprot F1MBB0 390
type: UnificationXref
id: F1MBB0
db: uniprot

uniprot Q9Z0X1 330
type: UnificationXref
id: Q9Z0X1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0D1C4Y4 138
xref: PTHR24055:SF158
organism: Ustilago maydis

MKK7
type: Protein
entity reference: MKK7
feature: MKK7 s108 a134 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q5BBL8 819
organism: Emericella nidulans

uniprot D3ZFJ0 563
type: UnificationXref
id: D3ZFJ0
db: uniprot

P00327
type: UnificationXref
id: P00327
db: PANTHER Pathway Component

P00325
type: UnificationXref
id: P00325
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__AIF-RIGHT__AIF-_r36
controller: Bak

P00326
type: UnificationXref
id: P00326
db: PANTHER Pathway Component

P00323
type: UnificationXref
id: P00323
db: PANTHER Pathway Component

P00324
type: UnificationXref
id: P00324
db: PANTHER Pathway Component

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot Q4KSH7 612
organism: Rattus norvegicus

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot A8XUK9 124
organism: Caenorhabditis briggsae

PTHR10454:SF162
type: RelationshipXref
id: PTHR10454:SF162
db: PANTHER Family
relationship type: By Homology

ncbitaxon 64091 544
type: UnificationXref
id: 64091
db: ncbitaxon

Mitogen-activated protein kinase 5
type: ProteinReference
xref: PTHR24055:SF391
xref: uniprot Q10N20 170
organism: Oryza sativa

uniprot A6H6W7 82
type: UnificationXref
id: A6H6W7
db: uniprot

uniprot Q869N1 875
type: UnificationXref
id: Q869N1
db: uniprot

uniprot P18291 108
type: UnificationXref
id: P18291
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6XP81 61
organism: Xenopus tropicalis

uniprot Q60989 505
type: UnificationXref
id: Q60989
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GNW3 395
organism: Macaca mulatta

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot F6PXH5 632
xref: PTHR48013:SF21
organism: Ornithorhynchus anatinus

uniprot Q9DGD9 249
type: UnificationXref
id: Q9DGD9
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_r104
control type: INHIBITION
controller: c-IAP1,2

uniprot Q10N20 170
type: UnificationXref
id: Q10N20
db: uniprot

PTHR13008:SF7
type: RelationshipXref
id: PTHR13008:SF7
db: PANTHER Family
relationship type: By Homology

uniprot Q9JM53 328
type: UnificationXref
id: Q9JM53
db: uniprot

uniprot F1PCU1 392
type: UnificationXref
id: F1PCU1
db: uniprot

Cyclic AMP-dependent transcription factor ATF-4
type: ProteinReference
xref: PTHR13044:SF2
xref: uniprot Q06507 483
organism: Mus musculus

P00312
type: UnificationXref
id: P00312
db: PANTHER Pathway Component

P00313
type: UnificationXref
id: P00313
db: PANTHER Pathway Component

P00314
type: UnificationXref
id: P00314
db: PANTHER Pathway Component

P00315
type: UnificationXref
id: P00315
db: PANTHER Pathway Component

IkappaB
type: Protein
entity reference: IkappaB
feature: IkappaB s98 a121 rs1
feature: IkappaB s98 a121 rs2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

P00316
type: UnificationXref
id: P00316
db: PANTHER Pathway Component

P00317
type: UnificationXref
id: P00317
db: PANTHER Pathway Component

uniprot F7FLN8 96
type: UnificationXref
id: F7FLN8
db: uniprot

P00318
type: UnificationXref
id: P00318
db: PANTHER Pathway Component

P00319
type: UnificationXref
id: P00319
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r50
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 1074
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 1075
left: Caspase 3
interaction type: STATE_TRANSITION
right: Caspase 3

GCK
type: Protein
entity reference: GCK
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Stress-activated protein kinase JNK
type: ProteinReference
xref: uniprot P92208 245
xref: PTHR24055:SF341
organism: Drosophila melanogaster

P00320
type: UnificationXref
id: P00320
db: PANTHER Pathway Component

Bok
type: ProteinReference
xref: P00261
standard name: Bcl-2 related ovarian killer
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Bcl-2 related ovarian killer Synonym: Synonym not specified Accession: P00261
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bok
member entity reference: Bcl-2-related ovarian killer protein
member entity reference: Uncharacterized protein
member entity reference: BOK protein
member entity reference: BCL2 family apoptosis regulator BOK

P00322
type: UnificationXref
id: P00322
db: PANTHER Pathway Component

Mitogen-activated protein kinase kinase kinase kinase 3
type: ProteinReference
xref: uniprot Q924I2 608
organism: Rattus norvegicus

uniprot Q9UBN6 265
type: UnificationXref
id: Q9UBN6
db: uniprot

P00321
type: UnificationXref
id: P00321
db: PANTHER Pathway Component

GLH-binding kinase 1
type: ProteinReference
xref: uniprot O44408 238
organism: Caenorhabditis elegans

uniprot P22934 341
type: UnificationXref
id: P22934
db: uniprot

Diva
type: ProteinReference
xref: P00285
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Diva Synonym: Bcl2-like 10,Bcl2L10 Accession: P00285
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Diva
member entity reference: Bcl-2-like protein 10
member entity reference: BCL2 like 10
member entity reference: Uncharacterized protein

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 12

Activating transcription factor 2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot F7EVK3 456
organism: Monodelphis domestica

P00309
type: UnificationXref
id: P00309
db: PANTHER Pathway Component

uniprot H2QC53 212
type: UnificationXref
id: H2QC53
db: uniprot

P00303
type: UnificationXref
id: P00303
db: PANTHER Pathway Component

P00304
type: UnificationXref
id: P00304
db: PANTHER Pathway Component

uniprot P10592 780
type: UnificationXref
id: P10592
db: uniprot

P00301
type: UnificationXref
id: P00301
db: PANTHER Pathway Component

P00302
type: UnificationXref
id: P00302
db: PANTHER Pathway Component

P00307
type: UnificationXref
id: P00307
db: PANTHER Pathway Component

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Caspase and RIP adapter
type: ProteinReference
xref: uniprot A0A1D5QRW9 370
xref: PTHR15034:SF5
organism: Macaca mulatta

P00308
type: UnificationXref
id: P00308
db: PANTHER Pathway Component

P00305
type: UnificationXref
id: P00305
db: PANTHER Pathway Component

INHIBITION
type: RelationshipTypeVocabulary

P00306
type: UnificationXref
id: P00306
db: PANTHER Pathway Component

uniprot Q1L8X3 551
type: UnificationXref
id: Q1L8X3
db: uniprot

P00311
type: UnificationXref
id: P00311
db: PANTHER Pathway Component

P00310
type: UnificationXref
id: P00310
db: PANTHER Pathway Component

PTHR19304:SF10
type: RelationshipXref
id: PTHR19304:SF10
db: PANTHER Family
relationship type: By Homology

PTHR15034:SF5
type: RelationshipXref
id: PTHR15034:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q01201 404
type: UnificationXref
id: Q01201
db: uniprot

uniprot Q9VEZ5 628
type: UnificationXref
id: Q9VEZ5
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A9U4N3 729
xref: PTHR19375:SF395
organism: Physcomitrella patens

uniprot K7CBH8 678
type: UnificationXref
id: K7CBH8
db: uniprot

uniprot P29596 479
type: UnificationXref
id: P29596
db: uniprot

MADD
type: Protein
entity reference: MADD
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa25 942
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot D3ZXB1 128
organism: Rattus norvegicus

uniprot P22953 795
type: UnificationXref
id: P22953
db: uniprot

BCL2 like 1
type: ProteinReference
xref: uniprot Q76LT7 21
xref: PTHR11256:SF12
organism: Canis lupus familiaris

uniprot O19131 339
type: UnificationXref
id: O19131
db: uniprot

uniprot F7GLY8 634
type: UnificationXref
id: F7GLY8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF210
xref: uniprot F7CZ86 753
organism: Macaca mulatta

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P02340 213
organism: Mus musculus

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot O93602 469
organism: Gallus gallus

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

IkappaB s12 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

uniprot K7CAG9 707
type: UnificationXref
id: K7CAG9
db: uniprot

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot D4A5L9 844
xref: PTHR11961:SF15
organism: Rattus norvegicus

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

uniprot P20718 109
type: UnificationXref
id: P20718
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7HLC7 578
xref: PTHR10048:SF35
organism: Macaca mulatta

uniprot P16599 36
type: UnificationXref
id: P16599
db: uniprot

Tumor necrosis factor ligand superfamily member 10
type: ProteinReference
xref: uniprot P50591 92
xref: PTHR11471:SF27
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r130 1114
type: Stoichiometry
physical entity: FAS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r130 1115
type: Stoichiometry
physical entity: FAS ligand
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r130 1116
type: Stoichiometry
physical entity: Complex (FAS/FAS ligand)
stoichiometric coefficient: 1.0

uniprot P48094 38
type: UnificationXref
id: P48094
db: uniprot

Tumor necrosis factor ligand superfamily member 10
type: ProteinReference
xref: PTHR11471:SF27
xref: uniprot P50592 93
organism: Mus musculus

cAMP responsive element binding protein 1
type: ProteinReference
xref: uniprot Q0V7N6 485
xref: PTHR45879:SF1
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GCKR-RIGHT__GCKR-_r55
controller: Complex (TRADD/RAIDD/ TRAF2/RIP)

STATE_TRANSITION_LEFT__PKCs-RIGHT__PKCs-_r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 991
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 990
left: PKCs
interaction type: STATE_TRANSITION
right: PKCs

uniprot P00002 853
type: UnificationXref
id: P00002
db: uniprot

CASP8 and FADD-like apoptosis regulator
type: ProteinReference
xref: PTHR10454:SF8
xref: uniprot O15519 316
organism: Homo sapiens

uniprot O95819 605
type: UnificationXref
id: O95819
db: uniprot

P00300
type: UnificationXref
id: P00300
db: PANTHER Pathway Component

BCL2 like 11
type: ProteinReference
xref: PTHR12044:SF9
xref: uniprot F7HHA9 883
organism: Macaca mulatta

ncbitaxon 5786 737
type: UnificationXref
id: 5786
db: ncbitaxon

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot O15111 622
organism: Homo sapiens

uniprot A0A3Q1LWJ8 223
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

uniprot A0A1D5QRW9 370
type: UnificationXref
id: A0A1D5QRW9
db: uniprot

Caspase-9
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot Q8C3Q9 416
organism: Mus musculus

uniprot A0A1D5QG41 711
type: UnificationXref
id: A0A1D5QG41
db: uniprot

uniprot A0A2I3RDV4 437
type: UnificationXref
id: A0A2I3RDV4
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF200
xref: uniprot G3X7B5 64
organism: Bos taurus

uniprot F6UKR4 5
type: UnificationXref
id: F6UKR4
db: uniprot

IKK
type: Protein
entity reference: IKK
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot O88879 434
type: UnificationXref
id: O88879
db: uniprot

PTHR13044:SF2
type: RelationshipXref
id: PTHR13044:SF2
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r53
controller: Complex (TRADD/RAIDD/ TRAF2/RIP)

uniprot P18850 477
type: UnificationXref
id: P18850
db: uniprot

PTHR10048:SF48
type: RelationshipXref
id: PTHR10048:SF48
db: PANTHER Family
relationship type: By Homology

TNF receptor-associated factor 2
type: ProteinReference
xref: uniprot P39429 518
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot F7DC98 754
organism: Monodelphis domestica

uniprot P41155 37
type: UnificationXref
id: P41155
db: uniprot

ncbitaxon 7227 77
type: UnificationXref
id: 7227
db: ncbitaxon

Heat shock protein SSA2
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot P10592 780
organism: Saccharomyces cerevisiae

Heat shock protein SSA1
type: ProteinReference
xref: uniprot P10591 779
xref: PTHR19375:SF426
organism: Saccharomyces cerevisiae

Heat shock 70 kDa protein 1A
type: ProteinReference
xref: PTHR19375:SF223
xref: uniprot Q61696 820
organism: Mus musculus

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 737

JNK
type: ProteinReference
xref: P00274
standard name: Jun kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Jun kinase Synonym: c-Jun amino-terminal kinase Accession: P00274
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.JNK
member entity reference: Mitogen-activated protein kinase
member entity reference: Uncharacterized protein
member entity reference: GLH-binding kinase 1
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Stress-activated protein kinase JNK
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Stress-activated protein kinase jnk-1

Apoptosis inducing factor mitochondria associated 1
type: ProteinReference
xref: PTHR43557:SF4
xref: uniprot A0A2I3RZL6 323
organism: Pan troglodytes

IKK
type: Protein
entity reference: IKK
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P20444 688
type: UnificationXref
id: P20444
db: uniprot

uniprot P10144 107
type: UnificationXref
id: P10144
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: uniprot P17325 500
xref: PTHR11462:SF8
organism: Rattus norvegicus

Caspase 3
type: ProteinReference
xref: P00305
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Caspase 3
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase 3 Synonym: Cysteinyl aspartic acid-protease-3 Accession: P00305
member entity reference: Caspase-3
member entity reference: Uncharacterized protein
member entity reference: Caspase 3, apoptosis-related cysteine peptidase a

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

Caspase 10
type: ProteinReference
xref: PTHR10454:SF26
xref: uniprot A0A2I3RFE8 374
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r87
controller: Complex (FAS/DAXX/ FADD/FAS ligand)

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot I0FRT6 208
xref: PTHR11584:SF332
organism: Macaca mulatta

uniprot P25799 402
type: UnificationXref
id: P25799
db: uniprot

uniprot Q6P0S4 657
type: UnificationXref
id: Q6P0S4
db: uniprot

uniprot A0A1D5Q2F6 435
type: UnificationXref
id: A0A1D5Q2F6
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__endoG-RIGHT__endoG-_r35
controller: AIF

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r86
control type: INHIBITION
controller: Flip

STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r90
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 1117
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 1118
left: Caspase 3
interaction type: STATE_TRANSITION
right: Caspase 3

TNF
type: Protein
entity reference: TNF
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa22 960
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q9Z1E3 360
organism: Mus musculus

FAS
type: Protein
entity reference: FAS

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MXH6 207
xref: PTHR11584:SF332
organism: Bos taurus

mitochondrion
type: CellularLocationVocabulary
xref: GO GO:0005739 2

AIF
type: Protein
entity reference: AIF
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7165 75
type: UnificationXref
id: 7165
db: ncbitaxon

Bcl-2-like protein 1
type: ProteinReference
xref: PTHR11256:SF12
xref: uniprot P53563 11
organism: Rattus norvegicus

uniprot H2QDQ1 676
type: UnificationXref
id: H2QDQ1
db: uniprot

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot D3Z8I4 126
organism: Rattus norvegicus

uniprot F1N177 445
type: UnificationXref
id: F1N177
db: uniprot

uniprot O95817 282
type: UnificationXref
id: O95817
db: uniprot

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: uniprot P25799 402
xref: PTHR24169:SF9
organism: Mus musculus

uniprot Q13158 894
type: UnificationXref
id: Q13158
db: uniprot

uniprot P48023 891
type: UnificationXref
id: P48023
db: uniprot

uniprot H2QLB4 155
type: UnificationXref
id: H2QLB4
db: uniprot

uniprot O95429 713
type: UnificationXref
id: O95429
db: uniprot

STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r72
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 1025
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 1024
left: JNK
interaction type: STATE_TRANSITION
right: JNK

uniprot Q39027 177
type: UnificationXref
id: Q39027
db: uniprot

Complex (IGFR2/Granzyme B)
type: Complex
component stoichiometry: Granzyme B s23 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: IGFR2 s22 sa19 STOICHIOMETRY ID COMPLEX
component: IGFR2
component: Granzyme B
feature: COMPLEX BINDING FEATURE s193 a301 935
feature: COMPLEX BINDING FEATURE s193 a301 933
cellular location: intracellular

TNF receptor superfamily member 10b
type: ProteinReference
xref: uniprot A0A2I3S7P9 258
xref: PTHR46330:SF1
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7GLY8 634
organism: Macaca mulatta

uniprot Q84UI5 186
type: UnificationXref
id: Q84UI5
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__FAS-_FAS_ligand-RIGHT__Complex__FAS_FAS_ligand_-_r130
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r130 1114
participant stoichiometry: PARTICIPANT STOICHIOMETRY r130 1115
participant stoichiometry: PARTICIPANT STOICHIOMETRY r130 1116
left: FAS
left: FAS ligand
interaction type: HETERODIMER_ASSOCIATION
right: Complex (FAS/FAS ligand)

MEKK1
type: ProteinReference
xref: P00291
standard name: Mitogen-activated protein kinase kinase kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.MEKK1
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen-activated protein kinase kinase kinase 1 Synonym: MAPKKK1,MEK kinase,Map/Erk kinase kinase 1 Accession: P00291
member entity reference: Mitogen-activated protein kinase kinase kinase 1
member entity reference: Uncharacterized protein

uniprot H2QNG6 580
type: UnificationXref
id: H2QNG6
db: uniprot

uniprot Q7T0K2 103
type: UnificationXref
id: Q7T0K2
db: uniprot

Bim
type: Protein
entity reference: Bim
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P79996 244
type: UnificationXref
id: P79996
db: uniprot

uniprot A8JEU4 719
type: UnificationXref
id: A8JEU4
db: uniprot

uniprot Q9Z1E3 360
type: UnificationXref
id: Q9Z1E3
db: uniprot

uniprot F7HHA9 883
type: UnificationXref
id: F7HHA9
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot Q9VEZ5 628
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZR51 454
xref: PTHR46164:SF1
organism: Macaca mulatta

HETERODIMER_ASSOCIATION_LEFT__RIP-_RAIDD-_TRAF2-_TRADD-RIGHT__Complex__TRADD_RAIDD__TRAF2_RIP_-_r48
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1082
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1086
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1084
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1083
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 1085
left: TRADD
left: RAIDD
left: RIP
left: TRAF2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TRADD/RAIDD/ TRAF2/RIP)

Cyclic AMP-dependent transcription factor ATF-3
type: ProteinReference
xref: uniprot P29596 479
xref: PTHR23351:SF23
organism: Rattus norvegicus

Heat shock protein family A (Hsp70) member 5
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot F6S4U9 744
organism: Ornithorhynchus anatinus

ASK1 s231 a136 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MAP kinase-activating death domain protein
type: ProteinReference
xref: uniprot Q80U28 118
xref: PTHR13008:SF7
organism: Mus musculus

uniprot Q9WTQ0 704
type: UnificationXref
id: Q9WTQ0
db: uniprot

uniprot P62894 863
type: UnificationXref
id: P62894
db: uniprot

uniprot D3ZXB1 128
type: UnificationXref
id: D3ZXB1
db: uniprot

uniprot F1PZN1 600
type: UnificationXref
id: F1PZN1
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6RCU6 60
organism: Macaca mulatta

NFkappaB
type: Protein
entity reference: NFkappaB
feature: ACTIVE 25
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P0DMV9 776
type: UnificationXref
id: P0DMV9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot F6X927 618
organism: Macaca mulatta

uniprot A0A2I3TAV0 384
type: UnificationXref
id: A0A2I3TAV0
db: uniprot

uniprot F7E8W5 306
type: UnificationXref
id: F7E8W5
db: uniprot

uniprot O35732 317
type: UnificationXref
id: O35732
db: uniprot

uniprot E1B902 129
type: UnificationXref
id: E1B902
db: uniprot

uniprot Q9JHK1 417
type: UnificationXref
id: Q9JHK1
db: uniprot

uniprot I0FRT6 208
type: UnificationXref
id: I0FRT6
db: uniprot

Mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot A0A2I3SB47 610
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR11961:SF29
xref: uniprot F7BU07 847
organism: Macaca mulatta

Tumor necrosis factor ligand superfamily member 6
type: ProteinReference
xref: PTHR11471:SF33
xref: uniprot P63307 892
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6WX28 651
xref: PTHR23351:SF4
organism: Monodelphis domestica

uniprot P27638 164
type: UnificationXref
id: P27638
db: uniprot

uniprot A0A2I3SB47 610
type: UnificationXref
id: A0A2I3SB47
db: uniprot

uniprot K7C6D4 643
type: UnificationXref
id: K7C6D4
db: uniprot

uniprot Q792S6 87
type: UnificationXref
id: Q792S6
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42336 585
organism: Homo sapiens

Lymphotoxin-alpha
type: ProteinReference
xref: PTHR11471:SF31
xref: uniprot Q06332 41
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P42338 587
xref: PTHR10048:SF33
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 586
organism: Mus musculus

Heat shock 70 kDa protein 6
type: ProteinReference
xref: uniprot P17066 788
xref: PTHR19375:SF168
organism: Homo sapiens

AGAP011190-PA (Fragment)
type: ProteinReference
xref: uniprot Q7QHH7 535
organism: Anopheles gambiae

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 837

uniprot Q9LMM5 189
type: UnificationXref
id: Q9LMM5
db: uniprot

PTHR22845:SF5
type: RelationshipXref
id: PTHR22845:SF5
db: PANTHER Family
relationship type: By Homology

uniprot P05128 680
type: UnificationXref
id: P05128
db: uniprot

TNFR1
type: Protein
entity reference: TNFR1

uniprot P42338 587
type: UnificationXref
id: P42338
db: uniprot

uniprot P21708 162
type: UnificationXref
id: P21708
db: uniprot

uniprot A0A1D5PK36 120
type: UnificationXref
id: A0A1D5PK36
db: uniprot

uniprot O23236 157
type: UnificationXref
id: O23236
db: uniprot

Heat shock protein 70A
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A8JEU4 719
organism: Chlamydomonas reinhardtii

Protein kinase C eta type
type: ProteinReference
xref: uniprot Q64617 703
xref: PTHR24356:SF192
organism: Rattus norvegicus

TRAIL-R
type: ProteinReference
xref: P00276
standard name: TRAIL-receptor
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.RECEPTOR.TRAIL-R
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
comment: ENTITY_REFERENCE_NOTES=Long Name: TRAIL-receptor Synonym: APO2,Death receptor 4,TNFRSF10A,Tumor necrosis factor receptor superfamily, member 10A Accession: P00276
member entity reference: Tumor necrosis factor receptor superfamily member 10C
member entity reference: Tumor necrosis factor receptor superfamily member 10B
member entity reference: TNF receptor superfamily member 10d
member entity reference: TNF receptor superfamily member 10c
member entity reference: TNF receptor superfamily member 10a
member entity reference: Tumor necrosis factor receptor superfamily member 10D
member entity reference: Tumor necrosis factor receptor superfamily member 10A
member entity reference: TNF receptor superfamily member 10b

Bcl-2-like protein 11
type: ProteinReference
xref: PTHR12044:SF9
xref: uniprot O54918 887
organism: Mus musculus

GO GO:0005739 2
type: UnificationXref
id: GO:0005739
db: GO

ACTIVE 25
type: EntityFeature
comment: Active state

uniprot H9GW49 765
type: UnificationXref
id: H9GW49
db: uniprot

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63318 694
organism: Mus musculus

uniprot E2R6T4 495
type: UnificationXref
id: E2R6T4
db: uniprot

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63319 695
organism: Rattus norvegicus

ncbitaxon 321614 150
type: UnificationXref
id: 321614
db: ncbitaxon

MCL1 isoform 2
type: ProteinReference
xref: uniprot K7D0E2 548
xref: PTHR11256:SF46
organism: Pan troglodytes

uniprot G3V926 619
type: UnificationXref
id: G3V926
db: uniprot

PARTICIPANT STOICHIOMETRY r90 1118
type: Stoichiometry
physical entity: Caspase 3
stoichiometric coefficient: 1.0

uniprot Q00709 199
type: UnificationXref
id: Q00709
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot F6W7C8 571
xref: PTHR10048:SF34
organism: Macaca mulatta

uniprot Q6ZWX6 534
type: UnificationXref
id: Q6ZWX6
db: uniprot

PARTICIPANT STOICHIOMETRY r90 1117
type: Stoichiometry
physical entity: Caspase 3
stoichiometric coefficient: 1.0

uniprot O43521 886
type: UnificationXref
id: O43521
db: uniprot

PTHR24361:SF414
type: RelationshipXref
id: PTHR24361:SF414
db: PANTHER Family
relationship type: By Homology

uniprot Q8UUX0 78
type: UnificationXref
id: Q8UUX0
db: uniprot

uniprot A0A452DIJ1 286
type: UnificationXref
id: A0A452DIJ1
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A9RCV9 724
organism: Physcomitrella patens

uniprot D4A5Q1 564
type: UnificationXref
id: D4A5Q1
db: uniprot

TNFR2
type: Protein
entity reference: TNFR2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot A4FV00 225
type: UnificationXref
id: A4FV00
db: uniprot

uniprot E1B847 361
type: UnificationXref
id: E1B847
db: uniprot

TNF
type: Protein
entity reference: TNF
feature: COMPLEX PARTICIPANT BINDING FEATURE s247 sa27 946
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F7BD74 633
type: UnificationXref
id: F7BD74
db: uniprot

uniprot F6RCU6 60
type: UnificationXref
id: F6RCU6
db: uniprot

uniprot Q3U0V2 709
type: UnificationXref
id: Q3U0V2
db: uniprot

MADD isoform 3
type: ProteinReference
xref: PTHR13008:SF7
xref: uniprot H2QZL1 116
organism: Pan troglodytes

uniprot P28867 691
type: UnificationXref
id: P28867
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q61831 246
xref: PTHR24055:SF162
organism: Mus musculus

uniprot O08734 254
type: UnificationXref
id: O08734
db: uniprot

Eukaryotic translation initiation factor 2 subunit alpha homolog
type: ProteinReference
xref: uniprot Q9SIZ2 546
organism: Arabidopsis thaliana

Bcl-2-like protein 11
type: ProteinReference
xref: PTHR12044:SF9
xref: uniprot O43521 886
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot F6WMM9 748
organism: Monodelphis domestica

RELB proto-oncogene, NF-kB subunit
type: ProteinReference
xref: uniprot F1PJ94 393
organism: Canis lupus familiaris

uniprot P45984 240
type: UnificationXref
id: P45984
db: uniprot

uniprot B9UKH7 367
type: UnificationXref
id: B9UKH7
db: uniprot

Jun dimerization protein 2
type: ProteinReference
xref: uniprot P97875 481
organism: Mus musculus

PTHR48016:SF9
type: RelationshipXref
id: PTHR48016:SF9
db: PANTHER Family
relationship type: By Homology

uniprot Q02111 697
type: UnificationXref
id: Q02111
db: uniprot

RIP s11 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RIP
stoichiometric coefficient: 1.0

PI3K
type: Protein
entity reference: PI3K
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR44329:SF6
type: RelationshipXref
id: PTHR44329:SF6
db: PANTHER Family
relationship type: By Homology

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot P70677 513
organism: Mus musculus

PTHR13966:SF5
type: RelationshipXref
id: PTHR13966:SF5
db: PANTHER Family
relationship type: By Homology

Tumor necrosis factor
type: ProteinReference
xref: uniprot P16599 36
xref: PTHR11471:SF23
organism: Rattus norvegicus

B-cell leukemia/lymphoma 2 related protein A1c
type: ProteinReference
xref: PTHR11256:SF10
xref: uniprot Q0P538 310
organism: Mus musculus

uniprot Q04864 409
type: UnificationXref
id: Q04864
db: uniprot

uniprot Q6P6S1 102
type: UnificationXref
id: Q6P6S1
db: uniprot

uniprot P16951 472
type: UnificationXref
id: P16951
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__XIAP-RIGHT__XIAP-_r118
controller: Smac/Diablo

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_r104
controller: Apaf-1

uniprot Q07817 17
type: UnificationXref
id: Q07817
db: uniprot

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF380
xref: uniprot P11021 781
organism: Homo sapiens

TNF
type: Protein
entity reference: TNF
comment: SPECIES_TYPE=PROTEIN

uniprot Q9W6F2 313
type: UnificationXref
id: Q9W6F2
db: uniprot

uniprot A0A452DJ61 31
type: UnificationXref
id: A0A452DJ61
db: uniprot

uniprot P70345 645
type: UnificationXref
id: P70345
db: uniprot

Cyclic AMP-dependent transcription factor ATF-3 isoform 1
type: ProteinReference
xref: uniprot F7GUS9 458
xref: PTHR23351:SF23
organism: Macaca mulatta

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_r104
control type: INHIBITION
controller: XIAP

RAIDD s6 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RAIDD
stoichiometric coefficient: 1.0

Complex (TNFR1/TNF)
type: Complex
component stoichiometry: TNF s26 sa22 STOICHIOMETRY ID COMPLEX
component: TNF
component: TNFR1
feature: COMPLEX BINDING FEATURE s203 a320 959
feature: COMPLEX BINDING FEATURE s203 a320 957
feature: ACTIVE 25
cellular location: intracellular

Baculoviral IAP repeat-containing 2
type: ProteinReference
xref: uniprot Q6P6S1 102
organism: Rattus norvegicus

BCL2-like 1
type: ProteinReference
xref: PTHR11256:SF12
xref: uniprot Q90Z98 23
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RI29 382
organism: Macaca mulatta

STATE_TRANSITION_LEFT__MEKK1-RIGHT__MEKK1-_r70
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 1032
participant stoichiometry: PARTICIPANT STOICHIOMETRY r70 1031
left: MEKK1
interaction type: STATE_TRANSITION
right: MEKK1

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q9FXT7 187
xref: PTHR24055:SF196
organism: Chlamydomonas reinhardtii

IkappaB
type: Protein
entity reference: IkappaB
feature: IkappaB s101 a127 rs1
feature: IkappaB s101 a127 rs2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P11717 303
type: UnificationXref
id: P11717
db: uniprot

HSP70
type: Protein
entity reference: HSP70
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F7C3R1 752
type: UnificationXref
id: F7C3R1
db: uniprot

uniprot F7D279 131
type: UnificationXref
id: F7D279
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TEK9 268
organism: Monodelphis domestica

Heat shock 70 kDa protein C
type: ProteinReference
xref: uniprot P27420 796
xref: PTHR19375:SF144
organism: Caenorhabditis elegans

EIF2AK2 isoform 1
type: ProteinReference
xref: PTHR11042:SF163
xref: uniprot B9UKH7 367
organism: Pan troglodytes

uniprot A8X1S0 226
type: UnificationXref
id: A8X1S0
db: uniprot

Tumor necrosis factor receptor superfamily member 1A
type: ProteinReference
xref: uniprot O19131 339
organism: Bos taurus

STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r58
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1065
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1064
left: IKK
interaction type: STATE_TRANSITION
right: IKK

DNA helicase
type: ProteinReference
xref: uniprot F1QK71 740
organism: Danio rerio

uniprot F7C7H6 326
type: UnificationXref
id: F7C7H6
db: uniprot

Baculoviral IAP repeat containing 3
type: ProteinReference
xref: PTHR10044:SF99
xref: uniprot A0A2I3TNR8 94
organism: Pan troglodytes

uniprot F7GN93 235
type: UnificationXref
id: F7GN93
db: uniprot

uniprot Q92851 375
type: UnificationXref
id: Q92851
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: DISSOCIATION_LEFT__Complex__Bax_Bak_-RIGHT__Bax-_Bak-_r96
control type: INHIBITION
controller: Bcl-2

uniprot F6SHC1 617
type: UnificationXref
id: F6SHC1
db: uniprot

Bax inhibitor 1
type: ProteinReference
xref: uniprot Q0V882 272
organism: Bos taurus

uniprot F6TKL3 229
type: UnificationXref
id: F6TKL3
db: uniprot

uniprot Q9LHA8 839
type: UnificationXref
id: Q9LHA8
db: uniprot

uniprot F7FDA0 575
type: UnificationXref
id: F7FDA0
db: uniprot

NFkappaB s13 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NFkappaB
stoichiometric coefficient: 1.0

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9Y243 81
xref: PTHR24356:SF190
organism: Homo sapiens

uniprot Q9HD36 321
type: UnificationXref
id: Q9HD36
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11256:SF47
xref: uniprot F7H6U5 318
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r111 1027
type: Stoichiometry
physical entity: IGFR2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r111 1026
type: Stoichiometry
physical entity: Granzyme B
stoichiometric coefficient: 1.0

PI3K
type: Protein
entity reference: PI3K
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r111 1028
type: Stoichiometry
physical entity: Complex (IGFR2/Granzyme B)
stoichiometric coefficient: 1.0

BCL2 like 2
type: ProteinReference
xref: uniprot K7C6D4 643
xref: PTHR11256:SF51
organism: Pan troglodytes

STATE_TRANSITION_LEFT__Apaf_1-RIGHT__Apaf_1-_r101
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 1055
participant stoichiometry: PARTICIPANT STOICHIOMETRY r101 1054
left: Apaf-1
interaction type: STATE_TRANSITION
right: Apaf-1

uniprot Q5Z859 180
type: UnificationXref
id: Q5Z859
db: uniprot

Os05g0460000 protein
type: ProteinReference
xref: PTHR19375:SF445
xref: uniprot Q6L509 821
organism: Oryza sativa

uniprot A8WN50 720
type: UnificationXref
id: A8WN50
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKCs-RIGHT__PKCs-_r20
controller: Complex (TRADD/RAIDD/ TRAF2/RIP)

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q02156 698
organism: Homo sapiens

Anti-apoptosis
type: Pathway

uniprot E2RGU7 663
type: UnificationXref
id: E2RGU7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7FDA0 575
xref: PTHR10048:SF33
organism: Monodelphis domestica

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3S7P9 258
type: UnificationXref
id: A0A2I3S7P9
db: uniprot

Tumor necrosis factor receptor superfamily member 6
type: ProteinReference
xref: PTHR46874:SF1
xref: uniprot Q9BDP2 350
organism: Macaca mulatta

AKT
type: ProteinReference
xref: P00260
standard name: protein kinase B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein kinase B Synonym: PKB Accession: P00260
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.AKT
member entity reference: RAC serine/threonine-protein kinase
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-2
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-1

uniprot Q9ES19 493
type: UnificationXref
id: Q9ES19
db: uniprot

uniprot O08600 289
type: UnificationXref
id: O08600
db: uniprot

Bcl-2-like protein 11
type: ProteinReference
xref: PTHR12044:SF9
xref: uniprot J9NWV6 885
organism: Canis lupus familiaris

Caspase 7
type: Protein
entity reference: Caspase 7
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 146
organism: Bos taurus

uniprot Q07812 203
type: UnificationXref
id: Q07812
db: uniprot

Bcl-2-like protein 10
type: ProteinReference
xref: uniprot Q99M66 320
organism: Rattus norvegicus

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 84

Tumor necrosis factor receptor type 1-associated DEATH domain protein
type: ProteinReference
xref: uniprot Q3U0V2 709
organism: Mus musculus

BAG family molecular chaperone regulator 1
type: ProteinReference
xref: PTHR12329:SF16
xref: uniprot Q60739 284
organism: Mus musculus

Activating transcription factor 2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot A0A2I3RDV4 437
organism: Pan troglodytes

uniprot P50592 93
type: UnificationXref
id: P50592
db: uniprot

Activating transcription factor 2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot F1N177 445
organism: Bos taurus

STATE_TRANSITION_LEFT__Complex__Fos_c_Jun_-RIGHT__Complex__Fos_c_Jun_-_r75
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 1013
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 1014
left: Complex (Fos/c-Jun)
interaction type: STATE_TRANSITION
right: Complex (Fos/c-Jun)

uniprot P63307 892
type: UnificationXref
id: P63307
db: uniprot

eco ECO:0000316 308
type: UnificationXref
id: ECO:0000316
db: eco

Cytochrome c
type: ProteinReference
xref: uniprot Q869N1 875
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot F6WMP8 293
organism: Macaca mulatta

uniprot J9NS71 517
type: UnificationXref
id: J9NS71
db: uniprot

uniprot E2QY18 266
type: UnificationXref
id: E2QY18
db: uniprot

PTHR24055:SF401
type: RelationshipXref
id: PTHR24055:SF401
db: PANTHER Family
relationship type: By Homology

BCL2-like 1
type: ProteinReference
xref: PTHR11256:SF12
xref: uniprot H2QK53 9
organism: Pan troglodytes

PTHR24055:SF417
type: RelationshipXref
id: PTHR24055:SF417
db: PANTHER Family
relationship type: By Homology

HSPA5 isoform 1
type: ProteinReference
xref: PTHR19375:SF380
xref: uniprot H2PYQ3 759
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF210
xref: uniprot F6Z1G9 750
organism: Monodelphis domestica

MKK3
type: Protein
entity reference: MKK3
feature: MKK3 s104 a130 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Heat shock 70 kDa protein 18
type: ProteinReference
xref: PTHR19375:SF413
xref: uniprot Q9C7X7 838
organism: Arabidopsis thaliana

uniprot Q61160 895
type: UnificationXref
id: Q61160
db: uniprot

Cation-independent mannose-6-phosphate receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot P11717 303
organism: Homo sapiens

IKK
type: ProteinReference
xref: P00313
standard name: Inhibitor of kappa-B kinase
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.IKK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: I-kappa B kinase Synonym: Synonym not specified Accession: P00313
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta
member entity reference: Inhibitor of nuclear factor kappa B kinase subunit beta
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha
member entity reference: Conserved helix-loop-helix ubiquitous kinase
member entity reference: Uncharacterized protein

PTHR11471:SF23
type: RelationshipXref
id: PTHR11471:SF23
db: PANTHER Family
relationship type: By Homology

Granzyme B
type: Protein
entity reference: Granzyme B
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa20 936
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Kelch-like protein diablo
type: ProteinReference
xref: uniprot Q9VUU5 558
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7E823 151
organism: Monodelphis domestica

PTHR11471:SF27
type: RelationshipXref
id: PTHR11471:SF27
db: PANTHER Family
relationship type: By Homology

PTHR11471:SF29
type: RelationshipXref
id: PTHR11471:SF29
db: PANTHER Family
relationship type: By Homology

uniprot E7EXT6 52
type: UnificationXref
id: E7EXT6
db: uniprot

uniprot Q14790 423
type: UnificationXref
id: Q14790
db: uniprot

Cyclic AMP-dependent transcription factor ATF-3
type: ProteinReference
xref: uniprot Q60765 487
xref: PTHR23351:SF23
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r96 1099
type: Stoichiometry
physical entity: Complex (Bax/Bak)
stoichiometric coefficient: 1.0

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 22

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q08BT6 701
organism: Xenopus tropicalis

FADD
type: Protein
entity reference: FADD
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7955 24
type: UnificationXref
id: 7955
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Bax-_Bak-RIGHT__Complex__Bax_Bak_-_r95
controller: Bcl-w

uniprot F1PJ94 393
type: UnificationXref
id: F1PJ94
db: uniprot

Heat shock 70 kDa protein BIP1
type: ProteinReference
xref: uniprot Q6Z7B0 825
xref: PTHR19375:SF144
organism: Oryza sativa

uniprot Q29537 219
type: UnificationXref
id: Q29537
db: uniprot

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot A0A1D5PFJ6 715
organism: Gallus gallus

STATE_TRANSITION_LEFT__SEK1-RIGHT__SEK1-_r73
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 1020
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 1019
left: SEK1
interaction type: STATE_TRANSITION
right: SEK1

Endoplasmic reticulum chaperone BiP homolog
type: ProteinReference
xref: PTHR19375:SF157
xref: uniprot P20163 793
organism: Caenorhabditis elegans

uniprot Q6P4Y4 206
type: UnificationXref
id: Q6P4Y4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Bid-RIGHT__Bid-_r28
controller: Unknown adaptor

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__P53-RIGHT__P53-_r119
controller: PKR

Tumor necrosis factor receptor type 1-associated DEATH domain protein
type: ProteinReference
xref: PTHR14913:SF0
xref: uniprot Q15628 708
organism: Homo sapiens

TRAIL s17 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRAIL
stoichiometric coefficient: 1.0

PTHR11471:SF33
type: RelationshipXref
id: PTHR11471:SF33
db: PANTHER Family
relationship type: By Homology

PTHR11471:SF31
type: RelationshipXref
id: PTHR11471:SF31
db: PANTHER Family
relationship type: By Homology

uniprot O89110 422
type: UnificationXref
id: O89110
db: uniprot

Heat shock protein family A (Hsp70) member 1A
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot F6TJ80 745
organism: Xenopus tropicalis

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q02111 697
xref: PTHR24356:SF181
organism: Mus musculus

uniprot Q17941 71
type: UnificationXref
id: Q17941
db: uniprot

uniprot P05126 679
type: UnificationXref
id: P05126
db: uniprot

uniprot O75569 295
type: UnificationXref
id: O75569
db: uniprot

ASK1
type: Protein
entity reference: ASK1
feature: ASK1 s230 a129 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F7EVK3 456
type: UnificationXref
id: F7EVK3
db: uniprot

PTHR11042:SF163
type: RelationshipXref
id: PTHR11042:SF163
db: PANTHER Family
relationship type: By Homology

uniprot H2QEM8 194
type: UnificationXref
id: H2QEM8
db: uniprot

uniprot F1MYM3 567
type: UnificationXref
id: F1MYM3
db: uniprot

uniprot F7DUD6 573
type: UnificationXref
id: F7DUD6
db: uniprot

uniprot F6RU41 522
type: UnificationXref
id: F6RU41
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 152
organism: Xenopus tropicalis

TRAF2
type: ProteinReference
xref: P00306
standard name: TNF receptor-associated factor 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.TRAF2
comment: ENTITY_REFERENCE_NOTES=Long Name: TNF receptor-associated factor 2 Synonym: TRAP Accession: P00306
member entity reference: TNF receptor-associated factor
member entity reference: GH01161p
member entity reference: TNF receptor-associated factor 2

Bcl-2-related protein A1
type: ProteinReference
xref: PTHR11256:SF10
xref: uniprot Q07440 309
organism: Mus musculus

uniprot F7HLC7 578
type: UnificationXref
id: F7HLC7
db: uniprot

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot Q8MKI5 514
organism: Canis lupus familiaris

Mitogen-activated protein kinase kinase kinase kinase 4
type: ProteinReference
xref: uniprot O95819 605
organism: Homo sapiens

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P68404 696
organism: Mus musculus

BAG family molecular chaperone regulator 3
type: ProteinReference
xref: uniprot O95817 282
organism: Homo sapiens

FADD
type: Protein
entity reference: FADD
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa1 922
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F6U940 642
type: UnificationXref
id: F6U940
db: uniprot

uniprot Q9Y243 81
type: UnificationXref
id: Q9Y243
db: uniprot

FAS ligand
type: ProteinReference
xref: P00326
comment: ENTITY_REFERENCE_NOTES=Long Name: FAS ligand Synonym: APO-1 ligand,APT1LG1,CD95L,FASL,TNFSF6,Tumor necrosis factor ligand superfamily member 6 Accession: P00326
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.FAS_br_ligand
member entity reference: Tumor necrosis factor ligand superfamily member 6
member entity reference: FASLG isoform 1

uniprot Q80U28 118
type: UnificationXref
id: Q80U28
db: uniprot

uniprot F6U0K7 431
type: UnificationXref
id: F6U0K7
db: uniprot

uniprot O77627 497
type: UnificationXref
id: O77627
db: uniprot

Eukaryotic translation initiation factor 2 subunit alpha
type: ProteinReference
xref: uniprot Q9FE78 542
organism: Arabidopsis thaliana

uniprot F7E823 151
type: UnificationXref
id: F7E823
db: uniprot

STATE_TRANSITION_LEFT__NIK-RIGHT__NIK-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 980
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 979
left: NIK
interaction type: STATE_TRANSITION
right: NIK

PTHR46330:SF4
type: RelationshipXref
id: PTHR46330:SF4
db: PANTHER Family
relationship type: By Homology

Bcl-2-like protein 10
type: ProteinReference
xref: uniprot Q9HD36 321
organism: Homo sapiens

uniprot P97287 549
type: UnificationXref
id: P97287
db: uniprot

Os01g0885000 protein
type: ProteinReference
xref: uniprot Q8S0R8 876
organism: Oryza sativa

PTHR46330:SF2
type: RelationshipXref
id: PTHR46330:SF2
db: PANTHER Family
relationship type: By Homology

PTHR46330:SF1
type: RelationshipXref
id: PTHR46330:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q39024 175
type: UnificationXref
id: Q39024
db: uniprot

PTHR12044:SF9
type: RelationshipXref
id: PTHR12044:SF9
db: PANTHER Family
relationship type: By Homology

BAG family molecular chaperone regulator 4
type: ProteinReference
xref: PTHR12329:SF10
xref: uniprot Q8CI61 714
organism: Mus musculus

uniprot A0A2I3RSL3 438
type: UnificationXref
id: A0A2I3RSL3
db: uniprot

uniprot Q7QEJ7 594
type: UnificationXref
id: Q7QEJ7
db: uniprot

Protein CBR-HSP-70
type: ProteinReference
xref: PTHR19375:SF207
xref: uniprot A8Y1C9 722
organism: Caenorhabditis briggsae

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot H2QAS6 675
organism: Pan troglodytes

Caspase 10
type: ProteinReference
xref: P00295
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase 10 Synonym: Cysteinyl aspartic acid-protease-10 Accession: P00295
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Caspase 10
member entity reference: Caspase-10
member entity reference: Caspase 10

INHIBITION
type: Control
xref: INHIBITION
controlled: TRANSPORT_LEFT__Cytochrome_C-RIGHT__Cytochrome_C-_r26
control type: INHIBITION
controller: Bcl-xL

FADD
type: Protein
entity reference: FADD
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa35 910
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F6TJ80 745
type: UnificationXref
id: F6TJ80
db: uniprot

BCL2-like 2
type: ProteinReference
xref: PTHR11256:SF13
xref: uniprot F6TEC3 641
organism: Xenopus tropicalis

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot Q9JHG7 596
xref: PTHR10048:SF34
organism: Mus musculus

FAS
type: Protein
entity reference: FAS
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MKK3-RIGHT__MKK3-_r68
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 1035
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 1036
left: MKK3
interaction type: STATE_TRANSITION
right: MKK3

uniprot P0CB32 774
type: UnificationXref
id: P0CB32
db: uniprot

uniprot E1B8P9 146
type: UnificationXref
id: E1B8P9
db: uniprot

uniprot E2R541 325
type: UnificationXref
id: E2R541
db: uniprot

ncbitaxon 36329 831
type: UnificationXref
id: 36329
db: ncbitaxon

PTHR22969:SF13
type: RelationshipXref
id: PTHR22969:SF13
db: PANTHER Family
relationship type: By Homology

Mcl1
type: ProteinReference
xref: P00308
standard name: Myeloid cell leukemia 1
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Mcl1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Myeloid cell leukemia 1 Synonym: Synonym not specified Accession: P00308
member entity reference: MCL1 apoptosis regulator, BCL2 family member a
member entity reference: Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
member entity reference: MCL1 isoform 2
member entity reference: Induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1
member entity reference: Induced myeloid leukemia cell differentiation protein Mcl-1

uniprot F6WMP8 293
type: UnificationXref
id: F6WMP8
db: uniprot

uniprot Q5ZLX2 533
type: UnificationXref
id: Q5ZLX2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12329:SF16
xref: uniprot F6TYR2 280
organism: Macaca mulatta

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot O88351 623
organism: Mus musculus

uniprot A0A2I3RUZ2 257
type: UnificationXref
id: A0A2I3RUZ2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZV71 200
xref: PTHR11256:SF42
organism: Macaca mulatta

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P47196 69
organism: Rattus norvegicus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P47197 70
organism: Rattus norvegicus

uniprot Q7ZWD3 536
type: UnificationXref
id: Q7ZWD3
db: uniprot

uniprot H2Q4M6 97
type: UnificationXref
id: H2Q4M6
db: uniprot

uniprot O08863 98
type: UnificationXref
id: O08863
db: uniprot

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot A0A1D5PK36 120
organism: Gallus gallus

uniprot Q9JLV1 285
type: UnificationXref
id: Q9JLV1
db: uniprot

uniprot A0A3Q2TY19 224
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

uniprot E2RKR0 615
type: UnificationXref
id: E2RKR0
db: uniprot

uniprot I3ITC2 201
type: UnificationXref
id: I3ITC2
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05771 683
xref: PTHR24356:SF158
organism: Homo sapiens

Apoptosis-inducing factor 1, mitochondrial
type: ProteinReference
xref: uniprot O95831 327
xref: PTHR43557:SF4
organism: Homo sapiens

Death domain-associated protein 6
type: ProteinReference
xref: uniprot O35613 378
xref: PTHR12766:SF7
organism: Mus musculus

BAG family molecular chaperone regulator 4
type: ProteinReference
xref: PTHR12329:SF10
xref: uniprot O95429 713
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot E1B902 129
organism: Bos taurus

Mitogen-activated protein kinase kinase kinase kinase 1
type: ProteinReference
xref: uniprot P70218 133
organism: Mus musculus

Heat shock 70 kDa protein 3
type: ProteinReference
xref: PTHR19375:SF413
xref: uniprot O65719 769
organism: Arabidopsis thaliana

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot A0A1D5R985 658
organism: Macaca mulatta

Bad
type: Protein
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

CASP2 and RIPK1 domain containing adaptor with death domain
type: ProteinReference
xref: uniprot A0A2I3TFE7 371
xref: PTHR15034:SF5
organism: Pan troglodytes

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 544

uniprot F1PRG4 54
type: UnificationXref
id: F1PRG4
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E2RNP2 664
organism: Canis lupus familiaris

Bcl-2-like protein 1
type: ProteinReference
xref: PTHR11256:SF12
xref: uniprot F6UKR4 5
organism: Macaca mulatta

AGAP005775-PA
type: ProteinReference
xref: uniprot Q7Q6L7 273
organism: Anopheles gambiae

GCK
type: ProteinReference
xref: P00268
standard name: Germinal center kinase
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.GCK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Germinal center kinase Synonym: MAP4K2,Mitigen-activated protein kinase kinase kinase kinase 2,Rab8-interacting protein,Rab8IP Accession: P00268
member entity reference: Mitogen-activated protein kinase kinase kinase kinase
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 2
member entity reference: Happyhour, isoform A
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 1
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 5

uniprot A0A2I3RZ31 222
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

uniprot F6XKJ2 453
type: UnificationXref
id: F6XKJ2
db: uniprot

CASP8 isoform 11
type: ProteinReference
xref: uniprot H2QJ86 421
xref: PTHR10454:SF162
organism: Pan troglodytes

uniprot Q9JHX4 424
type: UnificationXref
id: Q9JHX4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot G1K268 757
xref: PTHR19375:SF223
organism: Canis lupus familiaris

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 75

Endonuclease G
type: ProteinReference
xref: uniprot Q3V5X8 291
xref: PTHR13966:SF5
organism: Rattus norvegicus

uniprot P06761 771
type: UnificationXref
id: P06761
db: uniprot

uniprot F1MWU9 738
type: UnificationXref
id: F1MWU9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F3S0 574
xref: PTHR10048:SF33
organism: Macaca mulatta

uniprot P19525 368
type: UnificationXref
id: P19525
db: uniprot

uniprot H2R0F7 884
type: UnificationXref
id: H2R0F7
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: uniprot Q62925 366
xref: PTHR24361:SF414
organism: Rattus norvegicus

FAS-associated death domain protein
type: ProteinReference
xref: PTHR15077:SF9
xref: uniprot Q13158 894
organism: Homo sapiens

uniprot O35099 210
type: UnificationXref
id: O35099
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E9PU78 877
organism: Rattus norvegicus

uniprot Q99170 836
type: UnificationXref
id: Q99170
db: uniprot

PARTICIPANT STOICHIOMETRY r72 1024
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 1025
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

uniprot F6X927 618
type: UnificationXref
id: F6X927
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot P48736 588
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r54 1069
type: Stoichiometry
physical entity: Caspase 10
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r54 1068
type: Stoichiometry
physical entity: Caspase 10
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H2PXY8 579
xref: PTHR10048:SF35
organism: Pan troglodytes

SODD
type: ProteinReference
xref: P00320
standard name: Silencer of death domains
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.SODD
comment: ENTITY_REFERENCE_NOTES=Long Name: Silencer of death domains Synonym: Bag4,Bcl2-associated athanogene 4 Accession: P00320
member entity reference: BAG4 isoform 1
member entity reference: BAG family molecular chaperone regulator 4
member entity reference: Uncharacterized protein

uniprot P12841 656
type: UnificationXref
id: P12841
db: uniprot

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

Bcl-2 homologous antagonist/killer
type: ProteinReference
xref: uniprot O08734 254
xref: PTHR11256:SF41
organism: Mus musculus

uniprot G3V7X9 460
type: UnificationXref
id: G3V7X9
db: uniprot

PKCs
type: ProteinReference
xref: P00318
standard name: Protein kinase C
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.PKCs
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein kinase C Synonym: Synonym not specified Accession: P00318
member entity reference: Protein kinase C theta type
member entity reference: Protein kinase C-like 1B
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C eta type
member entity reference: Protein kinase C, brain isozyme
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C-like 1
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C gamma type (Fragment)

Blk
type: Protein
entity reference: Blk
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P27699 478
type: UnificationXref
id: P27699
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9XXC0 252
organism: Caenorhabditis elegans

Transcription factor AP-1
type: ProteinReference
xref: uniprot P05412 498
xref: PTHR11462:SF8
organism: Homo sapiens

PTHR19375:SF418
type: RelationshipXref
id: PTHR19375:SF418
db: PANTHER Family
relationship type: By Homology

PTHR19375:SF417
type: RelationshipXref
id: PTHR19375:SF417
db: PANTHER Family
relationship type: By Homology

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P16054 686
organism: Mus musculus

STATE_TRANSITION_LEFT__Bim-RIGHT__Bim-_re79
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re79 1077
participant stoichiometry: PARTICIPANT STOICHIOMETRY re79 1076
left: Bim
interaction type: STATE_TRANSITION
right: Bim

Heat shock protein family A (Hsp70) member 2
type: ProteinReference
xref: uniprot E2QX84 735
xref: PTHR19375:SF382
organism: Canis lupus familiaris

PTHR19375:SF413
type: RelationshipXref
id: PTHR19375:SF413
db: PANTHER Family
relationship type: By Homology

uniprot Q95KV0 625
type: UnificationXref
id: Q95KV0
db: uniprot

Tumor necrosis factor
type: ProteinReference
xref: uniprot P01375 33
xref: PTHR11471:SF23
organism: Homo sapiens

uniprot Q924I2 608
type: UnificationXref
id: Q924I2
db: uniprot

Lymphotoxin-alpha
type: ProteinReference
xref: uniprot P01374 32
organism: Homo sapiens

uniprot F7HB38 459
type: UnificationXref
id: F7HB38
db: uniprot

uniprot O15519 316
type: UnificationXref
id: O15519
db: uniprot

uniprot P28482 166
type: UnificationXref
id: P28482
db: uniprot

Caspase 3
type: Protein
entity reference: Caspase 3
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__GCKR-RIGHT__GCKR-_r55
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 1067
participant stoichiometry: PARTICIPANT STOICHIOMETRY r55 1066
left: GCKR
interaction type: STATE_TRANSITION
right: GCKR

uniprot P63018 805
type: UnificationXref
id: P63018
db: uniprot

uniprot F7BYI4 671
type: UnificationXref
id: F7BYI4
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

ATF1 isoform 2
type: ProteinReference
xref: PTHR45879:SF2
xref: uniprot H2Q5X1 463
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1PMN2 228
xref: PTHR24055:SF162
organism: Canis lupus familiaris

PTHR24055:SF378
type: RelationshipXref
id: PTHR24055:SF378
db: PANTHER Family
relationship type: By Homology

Mitochondrial cytochrome c
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot A8J5T0 843
organism: Chlamydomonas reinhardtii

uniprot Q90660 104
type: UnificationXref
id: Q90660
db: uniprot

uniprot P63017 804
type: UnificationXref
id: P63017
db: uniprot

Caspase 9, isoform CRA_a
type: ProteinReference
xref: uniprot Q9JHK1 417
xref: PTHR10454:SF157
organism: Rattus norvegicus

Heat shock protein family A (Hsp70) member 1 like
type: ProteinReference
xref: uniprot H2R7H0 760
xref: PTHR19375:SF210
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r49 1080
type: Stoichiometry
physical entity: Caspase 10
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r49 1081
type: Stoichiometry
physical entity: Caspase 10
stoichiometric coefficient: 1.0

Bcl 2 s20 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Bcl-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re79 1077
type: Stoichiometry
physical entity: Bim
stoichiometric coefficient: 1.0

A1-d protein
type: ProteinReference
xref: PTHR11256:SF10
xref: uniprot O55179 307
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re79 1076
type: Stoichiometry
physical entity: Bim
stoichiometric coefficient: 1.0

Cytochrome C
type: ProteinReference
xref: P00322
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Cytochrome C
comment: ENTITY_REFERENCE_NOTES=Long Name: Cytochrome C Synonym: Synonym not specified Accession: P00322
member entity reference: Cytochrome c iso-1
member entity reference: Cytochrome c, somatic
member entity reference: Cytochrome c, testis-specific
member entity reference: Uncharacterized protein
member entity reference: Cytochrome c
member entity reference: Cytochrome c iso-2
member entity reference: Cytochrome c-2
member entity reference: Cytochrome c-1
member entity reference: Mitochondrial cytochrome c
member entity reference: Cytochrome c 2.1
member entity reference: Cytochrome c 2
member entity reference: Os01g0885000 protein
member entity reference: Probable cytochrome c 2.2

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7FHD1 154
xref: PTHR24055:SF203
organism: Monodelphis domestica

uniprot A0A1D5R1G4 353
type: UnificationXref
id: A0A1D5R1G4
db: uniprot

uniprot D4A7Z5 553
type: UnificationXref
id: D4A7Z5
db: uniprot

IGFR2
type: Protein
entity reference: IGFR2
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa19 934
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q7Q7Y8 827
type: UnificationXref
id: Q7Q7Y8
db: uniprot

Death domain-containing protein CRADD
type: ProteinReference
xref: uniprot P78560 373
organism: Homo sapiens

Baculoviral IAP repeat-containing 2
type: ProteinReference
xref: uniprot Q7T0K2 103
organism: Danio rerio

PTHR19375:SF431
type: RelationshipXref
id: PTHR19375:SF431
db: PANTHER Family
relationship type: By Homology

MADD
type: Protein
entity reference: MADD
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q7ZVK8 185
type: UnificationXref
id: Q7ZVK8
db: uniprot

TNF s249 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

PTHR19375:SF436
type: RelationshipXref
id: PTHR19375:SF436
db: PANTHER Family
relationship type: By Homology

PTHR15018:SF1
type: RelationshipXref
id: PTHR15018:SF1
db: PANTHER Family
relationship type: By Homology

Endonuclease G, mitochondrial
type: ProteinReference
xref: uniprot Q14249 290
organism: Homo sapiens

uniprot Q5U2Z4 410
type: UnificationXref
id: Q5U2Z4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19304:SF10
xref: uniprot F1N1U0 446
organism: Bos taurus

DISSOCIATION
type: InteractionVocabulary

DAXX
type: Protein
entity reference: DAXX
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa34 908
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR10602:SF0
type: RelationshipXref
id: PTHR10602:SF0
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5PXC6 221
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

IkappaB s12 sa7 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ncbitaxon 367110 193
type: UnificationXref
id: 367110
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F5HEA9 149
xref: PTHR24055:SF158
organism: Phaeosphaeria nodorum

TRAIL
type: Protein
entity reference: TRAIL
comment: SPECIES_TYPE=PROTEIN

Heat shock protein SSA4
type: ProteinReference
xref: uniprot P22202 794
xref: PTHR19375:SF385
organism: Saccharomyces cerevisiae

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot Q99683 211
xref: PTHR11584:SF332
organism: Homo sapiens

uniprot A1XG22 386
type: UnificationXref
id: A1XG22
db: uniprot

PARTICIPANT STOICHIOMETRY r53 1071
type: Stoichiometry
physical entity: Caspase 8
stoichiometric coefficient: 1.0

P53
type: Protein
entity reference: P53
feature: ACTIVE 25
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r53 1070
type: Stoichiometry
physical entity: Caspase 8
stoichiometric coefficient: 1.0

Pro-apoptotic
type: Pathway

PI-3 kinase
type: ProteinReference
xref: uniprot P91634 593
xref: PTHR10048:SF14
organism: Drosophila melanogaster

FAS ligand
type: Protein
entity reference: FAS ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa36 912
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR46164:SF1
type: RelationshipXref
id: PTHR46164:SF1
db: PANTHER Family
relationship type: By Homology

PTHR46164:SF2
type: RelationshipXref
id: PTHR46164:SF2
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r96 1100
type: Stoichiometry
physical entity: Bax
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PACT-RIGHT__PACT-_r116
control type: ACTIVATION
controller: ds-RNA

uniprot O59855 768
type: UnificationXref
id: O59855
db: uniprot

PTHR19375:SF426
type: RelationshipXref
id: PTHR19375:SF426
db: PANTHER Family
relationship type: By Homology

Bcl-2-like protein 2
type: ProteinReference
xref: PTHR11256:SF13
xref: uniprot Q92843 647
organism: Homo sapiens

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 18

uniprot C8V7D1 144
type: UnificationXref
id: C8V7D1
db: uniprot

ncbitaxon 185431 813
type: UnificationXref
id: 185431
db: ncbitaxon

uniprot Q7TQN4 411
type: UnificationXref
id: Q7TQN4
db: uniprot

uniprot H2Q5X1 463
type: UnificationXref
id: H2Q5X1
db: uniprot

PARTICIPANT STOICHIOMETRY r96 1101
type: Stoichiometry
physical entity: Bak
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ELF2alpha-RIGHT__ELF2alpha-_r117
controller: PKR

uniprot P48736 588
type: UnificationXref
id: P48736
db: uniprot

IkappaB s12 sa7 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.9622796218629746
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot P36940 889
type: UnificationXref
id: P36940
db: uniprot

uniprot Q84TA1 828
type: UnificationXref
id: Q84TA1
db: uniprot

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

uniprot D3Z8I4 126
type: UnificationXref
id: D3Z8I4
db: uniprot

Translation initiation factor 2 subunit alpha
type: ProteinReference
xref: uniprot Q9HRT8 543
organism: Halobacterium salinarum

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot E1BJH5 599
organism: Bos taurus

A1
type: Protein
entity reference: A1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r118 1003
type: Stoichiometry
physical entity: XIAP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r118 1004
type: Stoichiometry
physical entity: XIAP
stoichiometric coefficient: 1.0

Cytochrome c
type: ProteinReference
xref: uniprot P99998 868
organism: Pan troglodytes

Cytochrome c
type: ProteinReference
xref: uniprot P99999 869
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r50
controller: Caspase 10

uniprot P25963 356
type: UnificationXref
id: P25963
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SEK1-RIGHT__SEK1-_r73
controller: MEKK1

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Bax-_Bak-RIGHT__Complex__Bax_Bak_-_r95
controller: Bag

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot H9EU76 603
organism: Macaca mulatta

uniprot K7B5K7 301
type: UnificationXref
id: K7B5K7
db: uniprot

uniprot Q05KJ0 13
type: UnificationXref
id: Q05KJ0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6Y4G8 231
xref: PTHR24055:SF222
organism: Canis lupus familiaris

TNF receptor-associated factor
type: ProteinReference
xref: uniprot B5DFH7 515
organism: Rattus norvegicus

AGAP004192-PA
type: ProteinReference
xref: uniprot Q7PQK5 826
xref: PTHR19375:SF144
organism: Anopheles gambiae

PTHR19375:SF457
type: RelationshipXref
id: PTHR19375:SF457
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6STW5 845
xref: PTHR11961:SF15
organism: Monodelphis domestica

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot Q60680 624
organism: Mus musculus

Caspase-10
type: ProteinReference
xref: PTHR10454:SF26
xref: uniprot Q92851 375
organism: Homo sapiens

uniprot P78695 806
type: UnificationXref
id: P78695
db: uniprot

…
type: Stoichiometry
physical entity: FAS
stoichiometric coefficient: 3.0

MAP3K5 isoform 1
type: ProteinReference
xref: PTHR11584:SF332
xref: uniprot K7CFQ9 209
organism: Pan troglodytes

uniprot P99999 869
type: UnificationXref
id: P99999
db: uniprot

uniprot P53563 11
type: UnificationXref
id: P53563
db: uniprot

Apoptosis inducing factor mitochondria associated 1
type: ProteinReference
xref: PTHR43557:SF4
xref: uniprot E2R541 325
organism: Canis lupus familiaris

uniprot P68404 696
type: UnificationXref
id: P68404
db: uniprot

uniprot H2R5K3 363
type: UnificationXref
id: H2R5K3
db: uniprot

TRAF2
type: Protein
entity reference: TRAF2
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa30 948
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q9NR28 557
type: UnificationXref
id: Q9NR28
db: uniprot

Heat shock 70 kDa protein 1-like
type: ProteinReference
xref: uniprot P0CB32 774
xref: PTHR19375:SF210
organism: Bos taurus

uniprot Q08BT6 701
type: UnificationXref
id: Q08BT6
db: uniprot

Nuclear factor NF-kappa-B p105 subunit isoform 1
type: ProteinReference
xref: uniprot F6S0D1 394
xref: PTHR24169:SF9
organism: Macaca mulatta

PTHR19375:SF442
type: RelationshipXref
id: PTHR19375:SF442
db: PANTHER Family
relationship type: By Homology

…
type: Stoichiometry
physical entity: FAS
stoichiometric coefficient: 3.0

uniprot F7BU07 847
type: UnificationXref
id: F7BU07
db: uniprot

PTHR19375:SF448
type: RelationshipXref
id: PTHR19375:SF448
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF338
type: RelationshipXref
id: PTHR24055:SF338
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__GCK-RIGHT__GCK-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 986
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 987
left: GCK
interaction type: STATE_TRANSITION
right: GCK

uniprot P97875 481
type: UnificationXref
id: P97875
db: uniprot

PTHR19375:SF445
type: RelationshipXref
id: PTHR19375:SF445
db: PANTHER Family
relationship type: By Homology

uniprot P56286 528
type: UnificationXref
id: P56286
db: uniprot

uniprot F1MDC9 665
type: UnificationXref
id: F1MDC9
db: uniprot

uniprot A0A1D5RGZ3 425
type: UnificationXref
id: A0A1D5RGZ3
db: uniprot

PI3K
type: ProteinReference
xref: P00310
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphatidylinostol 3 kinase Synonym: Synonym not specified Accession: P00310
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.PI3K
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: AGAP000018-PA
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: PIK3CG isoform 1
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
member entity reference: Phosphatidylinositol 3-kinase 3
member entity reference: PI-3 kinase
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 3-kinase 1
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: Phosphatidylinositol 3-kinase 2

Nuclear factor NF-kappa-B p100 subunit
type: ProteinReference
xref: uniprot Q00653 403
xref: PTHR24169:SF21
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot F7D279 131
organism: Macaca mulatta

AKT
type: Protein
entity reference: AKT
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

BAG family molecular chaperone regulator 1
type: ProteinReference
xref: PTHR12329:SF16
xref: uniprot B0K019 278
organism: Rattus norvegicus

uniprot D3ZZC5 705
type: UnificationXref
id: D3ZZC5
db: uniprot

Heat shock protein 70
type: ProteinReference
xref: uniprot Q383E5 812
xref: PTHR19375:SF395
organism: Trypanosoma brucei

uniprot Q9FXT7 187
type: UnificationXref
id: Q9FXT7
db: uniprot

uniprot B0K019 278
type: UnificationXref
id: B0K019
db: uniprot

ATF7 isoform 2
type: ProteinReference
xref: PTHR19304:SF10
xref: uniprot H2Q627 464
organism: Pan troglodytes

Heat shock protein family A (Hsp70) member 5
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot F6UZ27 746
organism: Xenopus tropicalis

Interferon-inducible double-stranded RNA-dependent protein kinase activator A
type: ProteinReference
xref: uniprot Q2HJ92 296
xref: PTHR46205:SF2
organism: Bos taurus

uniprot H2RCD1 466
type: UnificationXref
id: H2RCD1
db: uniprot

uniprot P20459 526
type: UnificationXref
id: P20459
db: uniprot

FADD s64 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FADD
stoichiometric coefficient: 1.0

MKK7
type: ProteinReference
xref: P00312
standard name: Mitogen activated protein kinase kinase 7
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen activated protein kinase kinase 7 Synonym: JNK-activating kinase 2,JNKK2,MAP kinase kinase 7,MAPKK7 Accession: P00312
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.MKK7
member entity reference: Dual specificity mitogen-activated protein kinase kinase 7
member entity reference: Mitogen-activated protein kinase kinase 7

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q862Z7 47
type: UnificationXref
id: Q862Z7
db: uniprot

uniprot F7B5L8 233
type: UnificationXref
id: F7B5L8
db: uniprot

uniprot F6WV79 230
type: UnificationXref
id: F6WV79
db: uniprot

Lymphotoxin-alpha
type: ProteinReference
xref: uniprot P09225 35
organism: Mus musculus

uniprot B5DFH7 515
type: UnificationXref
id: B5DFH7
db: uniprot

uniprot Q9UER7 380
type: UnificationXref
id: Q9UER7
db: uniprot

uniprot A7MBB7 387
type: UnificationXref
id: A7MBB7
db: uniprot

uniprot P04637 214
type: UnificationXref
id: P04637
db: uniprot

PARTICIPANT STOICHIOMETRY r45 1087
type: Stoichiometry
physical entity: FADD
stoichiometric coefficient: 1.0

uniprot P20333 333
type: UnificationXref
id: P20333
db: uniprot

cAMP responsive element binding protein 1
type: ProteinReference
xref: uniprot F7FD05 457
xref: PTHR45879:SF1
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r45 1089
type: Stoichiometry
physical entity: Complex (FADD/TRADD)
stoichiometric coefficient: 1.0

uniprot Q92843 647
type: UnificationXref
id: Q92843
db: uniprot

PARTICIPANT STOICHIOMETRY r45 1088
type: Stoichiometry
physical entity: TRADD
stoichiometric coefficient: 1.0

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot A0A2I3T4Q0 614
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NIK-RIGHT__NIK-_r22
controller: Complex (TRADD/RAIDD/ TRAF2/RIP)

Heat shock protein family A (Hsp70) member 5
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot F1PIC7 739
organism: Canis lupus familiaris

BAK1 isoform 3
type: ProteinReference
xref: PTHR11256:SF41
xref: uniprot H2R7E3 253
organism: Pan troglodytes

ncbitaxon 3218 725
type: UnificationXref
id: 3218
db: ncbitaxon

RAIDD
type: Protein
entity reference: RAIDD
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot O35425 86
type: UnificationXref
id: O35425
db: uniprot

Bax s18 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Bax
stoichiometric coefficient: 1.0

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P09216 685
organism: Rattus norvegicus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P09215 684
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MYM3 567
xref: PTHR10048:SF33
organism: Bos taurus

Phosphatidylinositol 3-kinase 3
type: ProteinReference
xref: PTHR10048:SF48
xref: uniprot P54675 592
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 2
type: ProteinReference
xref: uniprot P54674 591
xref: PTHR10048:SF109
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 1
type: ProteinReference
xref: uniprot P54673 589
xref: PTHR10048:SF14
organism: Dictyostelium discoideum

uniprot Q9Z0F3 322
type: UnificationXref
id: Q9Z0F3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR14913:SF0
xref: uniprot F6WWG3 706
organism: Macaca mulatta

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF417
xref: uniprot Q6Z437 183
organism: Oryza sativa

uniprot P00046 858
type: UnificationXref
id: P00046
db: uniprot

KNOWN_TRANSITION_OMITTED_LEFT__Complex__TRAIL_R_TRAIL_-RIGHT__Unknown_adaptor-_r94
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 1106
participant stoichiometry: PARTICIPANT STOICHIOMETRY r94 1105
left: Complex (TRAIL-R/TRAIL)
interaction type: KNOWN_TRANSITION_OMITTED
right: Unknown adaptor

c-IAP1,2
type: Protein
entity reference: c-IAP1,2
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Protein kinase C-like 1
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot P34722 692
organism: Caenorhabditis elegans

MKK3 s115 a137 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TNFR2
type: ProteinReference
xref: P00287
standard name: Tumor necrosis factor receptor 2
comment: ENTITY_REFERENCE_NOTES=Long Name: Tumor necrosis factor receptor 2 Synonym: Synonym not specified Accession: P00287
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.RECEPTOR.TNFR2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Tumor necrosis factor receptor superfamily member 1B
member entity reference: TNF receptor superfamily member 1B

AKT
type: Protein
entity reference: AKT
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot A5A6H2 649
type: UnificationXref
id: A5A6H2
db: uniprot

endoG
type: Protein
entity reference: endoG
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MKW9 391
xref: PTHR24169:SF9
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot F7H3B3 672
organism: Macaca mulatta

uniprot H2Q9G4 319
type: UnificationXref
id: H2Q9G4
db: uniprot

PARTICIPANT STOICHIOMETRY r48 1082
type: Stoichiometry
physical entity: RIP
stoichiometric coefficient: 1.0

ncbitaxon 665079 143
type: UnificationXref
id: 665079
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r48 1083
type: Stoichiometry
physical entity: RAIDD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 1084
type: Stoichiometry
physical entity: TRAF2
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase kinase 4
type: ProteinReference
xref: uniprot P97820 606
organism: Mus musculus

Death domain-associated protein 6
type: ProteinReference
xref: uniprot Q9UER7 380
xref: PTHR12766:SF7
organism: Homo sapiens

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Bim-RIGHT__Bim-_re79
control type: INHIBITION
controller: Mcl1

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot H9EU39 677
organism: Macaca mulatta

uniprot Q9JHG7 596
type: UnificationXref
id: Q9JHG7
db: uniprot

uniprot Q61696 820
type: UnificationXref
id: Q61696
db: uniprot

uniprot O14798 263
type: UnificationXref
id: O14798
db: uniprot

ncbitaxon 9544 6
type: UnificationXref
id: 9544
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7C587 420
xref: PTHR10454:SF162
organism: Macaca mulatta

FADD
type: Protein
entity reference: FADD
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q8UVF8 506
type: UnificationXref
id: Q8UVF8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r90
controller: Caspase 10

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

uniprot A7F3M0 142
type: UnificationXref
id: A7F3M0
db: uniprot

uniprot P18846 474
type: UnificationXref
id: P18846
db: uniprot

uniprot Q1RMX3 646
type: UnificationXref
id: Q1RMX3
db: uniprot

uniprot P25119 334
type: UnificationXref
id: P25119
db: uniprot

uniprot F6TEC3 641
type: UnificationXref
id: F6TEC3
db: uniprot

uniprot F5HEA9 149
type: UnificationXref
id: F5HEA9
db: uniprot

uniprot Q9WUA6 79
type: UnificationXref
id: Q9WUA6
db: uniprot

Heat shock-related 70 kDa protein 2
type: ProteinReference
xref: uniprot P54652 803
xref: PTHR19375:SF382
organism: Homo sapiens

uniprot F7G9S0 85
type: UnificationXref
id: F7G9S0
db: uniprot

PARTICIPANT STOICHIOMETRY r116 1009
type: Stoichiometry
physical entity: PACT
stoichiometric coefficient: 1.0

uniprot E2RTH8 444
type: UnificationXref
id: E2RTH8
db: uniprot

uniprot Q9W3I9 520
type: UnificationXref
id: Q9W3I9
db: uniprot

Eukaryotic translation initiation factor 2 subunit 1
type: ProteinReference
xref: uniprot Q6ZWX6 534
xref: PTHR10602:SF0
organism: Mus musculus

uniprot Q943K7 835
type: UnificationXref
id: Q943K7
db: uniprot

TRAF2 s51 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRAF2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r116 1010
type: Stoichiometry
physical entity: PACT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 1085
type: Stoichiometry
physical entity: TRADD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 1086
type: Stoichiometry
physical entity: Complex (TRADD/RAIDD/ TRAF2/RIP)
stoichiometric coefficient: 1.0

Cytochrome c
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot Q0DI31 870
organism: Oryza sativa

Bcl-xL
type: Protein
entity reference: Bcl-xL
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P01375 33
type: UnificationXref
id: P01375
db: uniprot

PARTICIPANT STOICHIOMETRY r127 984
type: Stoichiometry
physical entity: MADD
stoichiometric coefficient: 1.0

Cytochrome c-1
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot O23138 852
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r127 983
type: Stoichiometry
physical entity: Complex (TNFR1/TNF)
stoichiometric coefficient: 1.0

uniprot Q90473 833
type: UnificationXref
id: Q90473
db: uniprot

PARTICIPANT STOICHIOMETRY r127 985
type: Stoichiometry
physical entity: Complex (TNFR1/TNF/ MADD)
stoichiometric coefficient: 1.0

Lymphotoxin-beta
type: ProteinReference
xref: uniprot P41155 37
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0R4IKK9 220
xref: PTHR24055:SF162
organism: Danio rerio

uniprot Q9JK59 256
type: UnificationXref
id: Q9JK59
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MYJ4 53
xref: PTHR24356:SF190
organism: Bos taurus

Candida albicans
type: BioSource
xref: ncbitaxon 237561 179

uniprot P01100 654
type: UnificationXref
id: P01100
db: uniprot

uniprot P14681 159
type: UnificationXref
id: P14681
db: uniprot

uniprot F6Y841 572
type: UnificationXref
id: F6Y841
db: uniprot

RELA isoform 1
type: ProteinReference
xref: uniprot G2HHW9 397
xref: PTHR24169:SF1
organism: Pan troglodytes

uniprot Q90593 834
type: UnificationXref
id: Q90593
db: uniprot

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

C-fos
type: ProteinReference
xref: uniprot A5A6H0 648
xref: PTHR23351:SF4
organism: Pan troglodytes

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

c-IAP1,2
type: Protein
entity reference: c-IAP1,2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR24055:SF391
type: RelationshipXref
id: PTHR24055:SF391
db: PANTHER Family
relationship type: By Homology

uniprot P42337 586
type: UnificationXref
id: P42337
db: uniprot

C-fos
type: ProteinReference
xref: uniprot A5A6H2 649
xref: PTHR23351:SF4
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot E2RJX4 51
organism: Canis lupus familiaris

uniprot P39745 167
type: UnificationXref
id: P39745
db: uniprot

PTHR12766:SF7
type: RelationshipXref
id: PTHR12766:SF7
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TGI5 385
type: UnificationXref
id: A0A2I3TGI5
db: uniprot

uniprot Q10NA9 810
type: UnificationXref
id: Q10NA9
db: uniprot

uniprot F6RLH5 743
type: UnificationXref
id: F6RLH5
db: uniprot

uniprot Q0V7N6 485
type: UnificationXref
id: Q0V7N6
db: uniprot

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot F7FCJ3 602
organism: Monodelphis domestica

Leishmania major
type: BioSource
xref: ncbitaxon 5664 816

Inhibitor of apoptosis protein
type: ProteinReference
xref: uniprot Q90660 104
organism: Gallus gallus

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot H2QNG6 580
xref: PTHR10048:SF33
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1Q4F8 55
xref: PTHR24356:SF190
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR13008:SF7
xref: uniprot A0A1D5QZY2 113
organism: Macaca mulatta

uniprot O35613 378
type: UnificationXref
id: O35613
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7F3M0 142
xref: PTHR24055:SF158
organism: Sclerotinia sclerotiorum

uniprot Q9QZM4 264
type: UnificationXref
id: Q9QZM4
db: uniprot

c Jun s15 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 308

uniprot P49950 198
type: UnificationXref
id: P49950
db: uniprot

uniprot H9EU39 677
type: UnificationXref
id: H9EU39
db: uniprot

uniprot F1MY82 666
type: UnificationXref
id: F1MY82
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q04759 699
xref: PTHR24356:SF181
organism: Homo sapiens

uniprot Q07813 204
type: UnificationXref
id: Q07813
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__RIP-_RAIDD-_TRAF2-_TRADD-RIGHT__Complex__TRADD_RAIDD__TRAF2_RIP_-_r48
controller: Complex (TNFR1/TNF)

uniprot C4M3S5 733
type: UnificationXref
id: C4M3S5
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7GN93 235
xref: PTHR24055:SF162
organism: Macaca mulatta

uniprot Q10265 809
type: UnificationXref
id: Q10265
db: uniprot

uniprot F1MKW9 391
type: UnificationXref
id: F1MKW9
db: uniprot

REL proto-oncogene, NF-kB subunit
type: ProteinReference
xref: uniprot A0A2I3TAV0 384
organism: Pan troglodytes

uniprot F1QMW2 502
type: UnificationXref
id: F1QMW2
db: uniprot

uniprot G1K372 851
type: UnificationXref
id: G1K372
db: uniprot

Heat shock cognate 70 kDa protein 1
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot P36415 800
organism: Dictyostelium discoideum

Baculoviral IAP repeat-containing 3
type: ProteinReference
xref: uniprot F7FLN8 96
organism: Rattus norvegicus

uniprot Q0V882 272
type: UnificationXref
id: Q0V882
db: uniprot

uniprot Q7PQK5 826
type: UnificationXref
id: Q7PQK5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BJA2 324
xref: PTHR43557:SF4
organism: Bos taurus

Heat shock 70 kDa protein 1-like
type: ProteinReference
xref: uniprot P16627 787
xref: PTHR19375:SF210
organism: Mus musculus

uniprot A0A0G2K7W4 598
type: UnificationXref
id: A0A0G2K7W4
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot Q8CE90 613
organism: Mus musculus

uniprot P0DMW1 778
type: UnificationXref
id: P0DMW1
db: uniprot

Caspase-8
type: ProteinReference
xref: uniprot Q9JHX4 424
xref: PTHR10454:SF162
organism: Rattus norvegicus

Probable mediator of RNA polymerase II transcription subunit 37b
type: ProteinReference
xref: PTHR19375:SF215
xref: uniprot Q8H1B3 829
organism: Arabidopsis thaliana

uniprot F6VXG1 570
type: UnificationXref
id: F6VXG1
db: uniprot

uniprot H2Q627 464
type: UnificationXref
id: H2Q627
db: uniprot

uniprot Q6PGX4 823
type: UnificationXref
id: Q6PGX4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FG25 288
organism: Macaca mulatta

uniprot E1BJA2 324
type: UnificationXref
id: E1BJA2
db: uniprot

uniprot F1NXP6 418
type: UnificationXref
id: F1NXP6
db: uniprot

uniprot Q9VQ79 329
type: UnificationXref
id: Q9VQ79
db: uniprot

TRAF2 s8 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRAF2
stoichiometric coefficient: 1.0

uniprot K7D0E2 548
type: UnificationXref
id: K7D0E2
db: uniprot

Jun dimerization protein 2
type: ProteinReference
xref: uniprot A0A2I3RSL3 438
organism: Pan troglodytes

uniprot Q5TM20 44
type: UnificationXref
id: Q5TM20
db: uniprot

uniprot P84029 867
type: UnificationXref
id: P84029
db: uniprot

uniprot H3E674 762
type: UnificationXref
id: H3E674
db: uniprot

uniprot G3V824 300
type: UnificationXref
id: G3V824
db: uniprot

P53
type: Protein
entity reference: P53
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

TNFR2 s248 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TNFR2
stoichiometric coefficient: 3.0

uniprot Q9FE78 542
type: UnificationXref
id: Q9FE78
db: uniprot

Apoptosis regulator BAX
type: ProteinReference
xref: uniprot Q07812 203
xref: PTHR11256:SF42
organism: Homo sapiens

Apoptosis regulator BAX
type: ProteinReference
xref: uniprot Q07813 204
xref: PTHR11256:SF42
organism: Mus musculus

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

HSPA8 isoform 16
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot A0A2J8N1X7 716
organism: Pan troglodytes

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

Bcl-2-like protein 1
type: ProteinReference
xref: uniprot Q07816 15
organism: Gallus gallus

Bcl-2-like protein 1
type: ProteinReference
xref: uniprot Q07817 17
xref: PTHR11256:SF12
organism: Homo sapiens

uniprot F1QLH0 419
type: UnificationXref
id: F1QLH0
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P79996 244
xref: PTHR24055:SF172
organism: Gallus gallus

Heat shock protein SSA1
type: ProteinReference
xref: uniprot P41797 802
xref: PTHR19375:SF426
organism: Candida albicans

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PUU3 448
organism: Monodelphis domestica

Tumor necrosis factor receptor type 1-associated DEATH domain protein
type: ProteinReference
xref: uniprot Q9I9N5 710
organism: Danio rerio

uniprot F7AGS1 83
type: UnificationXref
id: F7AGS1
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Pro-apoptotic
controller: Caspase 7

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot A8WR64 661
organism: Caenorhabditis briggsae

MODULATION
type: Control
xref: MODULATION
controlled: Pro-apoptotic
controller: Caspase 7

Induced myeloid leukemia cell differentiation protein Mcl-1
type: ProteinReference
xref: PTHR11256:SF46
xref: uniprot Q07820 550
organism: Homo sapiens

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

V-fos FBJ murine osteosarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot Q6P0S4 657
xref: PTHR23351:SF4
organism: Danio rerio

Bcl-2
type: Protein
entity reference: Bcl-2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q7QK56 74
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RCD1 466
xref: PTHR46164:SF2
organism: Pan troglodytes

PKR
type: ProteinReference
xref: P00293
standard name: Interferon-inducible double-stranded RNA-activated protein kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: Interferon-inducible double-stranded RNA-activated protein kinase Synonym: PKR,PRKR Accession: P00293
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.PKR
member entity reference: Interferon-induced, double-stranded RNA-activated protein kinase
member entity reference: EIF2AK2 isoform 1

uniprot Q8INI8 832
type: UnificationXref
id: Q8INI8
db: uniprot

PTHR19375:SF168
type: RelationshipXref
id: PTHR19375:SF168
db: PANTHER Family
relationship type: By Homology

uniprot P49187 242
type: UnificationXref
id: P49187
db: uniprot

TNFR1
type: Protein
entity reference: TNFR1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F7H9J1 362
type: UnificationXref
id: F7H9J1
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A2I3T9Y4 48
xref: PTHR24356:SF190
organism: Pan troglodytes

Predicted protein
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot A9S0A3 726
organism: Physcomitrella patens

uniprot Q8BTI9 595
type: UnificationXref
id: Q8BTI9
db: uniprot

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

MODULATION
type: Control
xref: MODULATION
controlled: Pro-apoptotic
controller: P53

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

uniprot E1BE66 565
type: UnificationXref
id: E1BE66
db: uniprot

uniprot F7EI48 153
type: UnificationXref
id: F7EI48
db: uniprot

PTHR19375:SF157
type: RelationshipXref
id: PTHR19375:SF157
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot K7BKY5 604
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot H9GW49 765
organism: Canis lupus familiaris

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot O77628 653
xref: PTHR23351:SF4
organism: Bos taurus

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot O77627 497
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Bax_Bak_-RIGHT__Bax-_Bak-_r96
controller: Bid

uniprot H2QZL1 116
type: UnificationXref
id: H2QZL1
db: uniprot

TRANSPORT_LEFT__AIF-RIGHT__AIF-_r36
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 1093
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 1092
left: AIF
interaction type: TRANSPORT
right: AIF

DnaK-type molecular chaperone hsp70-rice
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot Q53NM9 817
organism: Oryza sativa

uniprot Q99941 492
type: UnificationXref
id: Q99941
db: uniprot

uniprot P05198 525
type: UnificationXref
id: P05198
db: uniprot

Mitogen-activated protein kinase kinase kinase kinase 5
type: ProteinReference
xref: uniprot Q8BPM2 137
organism: Mus musculus

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P56424 216
organism: Macaca mulatta

TNF
type: Protein
entity reference: TNF
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa24 940
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Apoptotic protease-activating factor 1
type: ProteinReference
xref: uniprot O14727 433
xref: PTHR22845:SF5
organism: Homo sapiens

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r49
control type: INHIBITION
controller: SODD

…
type: Stoichiometry
physical entity: TNFR2
stoichiometric coefficient: 3.0

Bcl-w
type: Protein
entity reference: Bcl-w
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot H2R7E3 253
type: UnificationXref
id: H2R7E3
db: uniprot

Bcl-2
type: Protein
entity reference: Bcl-2
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P09446 773
type: UnificationXref
id: P09446
db: uniprot

MCL1 apoptosis regulator, BCL2 family member a
type: ProteinReference
xref: uniprot Q1L8X3 551
organism: Danio rerio

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot O14733 611
organism: Homo sapiens

Apoptosis signaling pathway
type: Pathway
pathway component: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r59
pathway component: TRANSPORT_LEFT__Cytochrome_C-RIGHT__Cytochrome_C-_r26
pathway component: HETERODIMER_ASSOCIATION_LEFT__TNF-_TNFR1-RIGHT__Complex__TNFR1_TNF_-_r123
pathway component: HETERODIMER_ASSOCIATION_LEFT__TRAF2-_Complex__TNFR2_TNF_-RIGHT__Complex__TNFR2_TNF__TRAF2_-_r129
pathway component: MODULATION
pathway component: STATE_TRANSITION_LEFT__ASK1-RIGHT__ASK1-_r67
pathway component: STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r12
pathway component: STATE_TRANSITION_LEFT__MEKK1-RIGHT__MEKK1-_r70
pathway component: STATE_TRANSITION_LEFT__Bcl_xL-RIGHT__Bcl_xL-_re78
pathway component: STATE_TRANSITION_LEFT__NIK-RIGHT__NIK-_r22
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Complex__TRAIL_R_TRAIL_-RIGHT__Unknown_adaptor-_r94
pathway component: STATE_TRANSITION_LEFT__ASK1-RIGHT__ASK1-_r83
pathway component: STATE_TRANSITION_LEFT__c_IAP1,2-RIGHT__c_IAP1,2-_r103
pathway component: STATE_TRANSITION_LEFT__SEK1-RIGHT__SEK1-_r73
pathway component: STATE_TRANSITION_LEFT__XIAP-RIGHT__XIAP-_r118
pathway component: HETERODIMER_ASSOCIATION_LEFT__FADD-_TRADD-RIGHT__Complex__FADD_TRADD_-_r45
pathway component: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r54
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__TNFR1_TNF_-_MADD-RIGHT__Complex__TNFR1_TNF__MADD_-_r127
pathway component: HETERODIMER_ASSOCIATION_LEFT__RIP-_RAIDD-_TRAF2-_TRADD-RIGHT__Complex__TRADD_RAIDD__TRAF2_RIP_-_r48
pathway component: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r105
pathway component: TRANSPORT_LEFT__NFkappaB-RIGHT__NFkappaB-_r61
pathway component: STATE_TRANSITION_LEFT__P53-RIGHT__P53-_r119
pathway component: STATE_TRANSITION_LEFT__IkappaB-RIGHT__IkappaB-_r60
pathway component: STATE_TRANSITION_LEFT__MKK7-RIGHT__MKK7-_r71
pathway component: STATE_TRANSITION_LEFT__PACT-RIGHT__PACT-_r116
pathway component: STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_r69
pathway component: STATE_TRANSITION_LEFT__FADD-_DAXX-_Complex__FAS_FAS_ligand_-RIGHT__Complex__FAS_DAXX__FADD_FAS_ligand_-_r131
pathway component: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r87
pathway component: STATE_TRANSITION_LEFT__MKK3-RIGHT__MKK3-_r68
pathway component: STATE_TRANSITION_LEFT__Bid-RIGHT__Bid-_r28
pathway component: STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_r104
pathway component: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r50
pathway component: STATE_TRANSITION_LEFT__Caspase_7-RIGHT__Caspase_7-_r51
pathway component: HETERODIMER_ASSOCIATION_LEFT__Bcl_2-_Bik-RIGHT__Complex__Bcl_2_Bik_-_r97
pathway component: TRANSPORT_LEFT__AIF-RIGHT__AIF-_r36
pathway component: STATE_TRANSITION_LEFT__PKR-RIGHT__PKR-_r115
pathway component: STATE_TRANSITION_LEFT__Caspase_7-RIGHT__Caspase_7-_r106
pathway component: DISSOCIATION_LEFT__Complex__IGFR2_Granzyme_B_-RIGHT__Granzyme_B-_IGFR2-_r112
pathway component: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r113
pathway component: HETERODIMER_ASSOCIATION_LEFT__Bax-_Bak-RIGHT__Complex__Bax_Bak_-_r95
pathway component: STATE_TRANSITION_LEFT__IkappaB-RIGHT__IkappaB-_r65
pathway component: HETERODIMER_ASSOCIATION_LEFT__TRAIL_R-_TRAIL-RIGHT__Complex__TRAIL_R_TRAIL_-_r92
pathway component: STATE_TRANSITION_LEFT__GCK-RIGHT__GCK-_r21
pathway component: STATE_TRANSITION_LEFT__PKCs-RIGHT__PKCs-_r20
pathway component: STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r72
pathway component: TRANSPORT_LEFT__endoG-RIGHT__endoG-_r35
pathway component: TRANSPORT_LEFT__P53-RIGHT__P53-_r120
pathway component: TRANSPORT_LEFT__Smac_Diablo-RIGHT__Smac_Diablo-_r37
pathway component: HETERODIMER_ASSOCIATION_LEFT__TNF-_TNFR2-RIGHT__Complex__TNFR2_TNF_-_r128
pathway component: STATE_TRANSITION_LEFT__Bcl_2-RIGHT__Bcl_2-_re80
pathway component: STATE_TRANSITION_LEFT__GCKR-RIGHT__GCKR-_r55
pathway component: HETERODIMER_ASSOCIATION_LEFT__Granzyme_B-_IGFR2-RIGHT__Complex__IGFR2_Granzyme_B_-_r111
pathway component: HETERODIMER_ASSOCIATION_LEFT__NFkappaB-_IkappaB-RIGHT__Complex__IkappaB_NFkappaB_-_r64
pathway component: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r90
pathway component: STATE_TRANSITION_LEFT__Bim-RIGHT__Bim-_re79
pathway component: STATE_TRANSITION_LEFT__Complex__Fos_c_Jun_-RIGHT__Complex__Fos_c_Jun_-_r75
pathway component: STATE_TRANSITION_LEFT__ATF-RIGHT__ATF-_r74
pathway component: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r49
pathway component: DISSOCIATION_LEFT__Complex__Bax_Bak_-RIGHT__Bax-_Bak-_r96
pathway component: STATE_TRANSITION_LEFT__IkappaB-RIGHT__a127_degraded-_r66
pathway component: HETERODIMER_ASSOCIATION_LEFT__FAS-_FAS_ligand-RIGHT__Complex__FAS_FAS_ligand_-_r130
pathway component: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r58
pathway component: STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r53
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r19
pathway component: STATE_TRANSITION_LEFT__Apaf_1-RIGHT__Apaf_1-_r101
pathway component: STATE_TRANSITION_LEFT__ELF2alpha-RIGHT__ELF2alpha-_r117
pathway component: STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r86
xref: PANTHER Pathway P00006 1
comment: MODEL_NOTES=Panther Pathway: P00006 Signal transduction pathways known to be associated with mediating the induction or inhibition of the cellular death processes. Primarily repesentative of the the death receptor pathways. Medline=10209152 Medline=10209153 Medline=10966458 Medline=11832206 Medline=12949498 Medline=14744432 Medline=14996498 Medline=9039262 Medline=9069264 Medline=9721089 Website=http://www-personal.umich.edu/~ino/List/AList.html Website=http://www.bdbiosciences.com/pdfs/newsletters/02-7900030-36-A1.pdf PMID: 10209152 PMID: 10209153 PMID: 10966458 PMID: 11832206 PMID: 12949498 PMID: 14744432 PMID: 14996498 PMID: 9039262 PMID: 9069264 PMID: 9721089

uniprot Q64373 19
type: UnificationXref
id: Q64373
db: uniprot

uniprot Q03060 482
type: UnificationXref
id: Q03060
db: uniprot

PARTICIPANT STOICHIOMETRY r37 1090
type: Stoichiometry
physical entity: Smac/Diablo
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1B847 361
xref: PTHR24361:SF414
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r37 1091
type: Stoichiometry
physical entity: Smac/Diablo
stoichiometric coefficient: 1.0

uniprot F7B742 879
type: UnificationXref
id: F7B742
db: uniprot

PTHR19375:SF144
type: RelationshipXref
id: PTHR19375:SF144
db: PANTHER Family
relationship type: By Homology

uniprot F7H3B3 672
type: UnificationXref
id: F7H3B3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10454:SF31
xref: uniprot A0A1D5RGZ3 425
organism: Macaca mulatta

BAK protein
type: ProteinReference
xref: uniprot Q9JK59 256
xref: PTHR11256:SF41
organism: Rattus norvegicus

uniprot Q9LQQ9 190
type: UnificationXref
id: Q9LQQ9
db: uniprot

uniprot K7BKY5 604
type: UnificationXref
id: K7BKY5
db: uniprot

SODD
type: Protein
entity reference: SODD
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re78 1079
type: Stoichiometry
physical entity: Bcl-xL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re78 1078
type: Stoichiometry
physical entity: Bcl-xL
stoichiometric coefficient: 1.0

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot O93417 510
organism: Gallus gallus

uniprot K7CIS5 554
type: UnificationXref
id: K7CIS5
db: uniprot

MEKK1 s112 a139 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot Q95KV0 625
organism: Bos taurus

uniprot A8WR64 661
type: UnificationXref
id: A8WR64
db: uniprot

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot Q95KV1 626
organism: Bos taurus

Tumor necrosis factor receptor superfamily member 1B
type: ProteinReference
xref: uniprot P25119 334
xref: PTHR47386:SF1
organism: Mus musculus

Tumor necrosis factor receptor superfamily member 1A
type: ProteinReference
xref: uniprot P25118 342
organism: Mus musculus

Complex (IkappaB/NFkappaB)
type: Complex
component stoichiometry: IkappaB s12 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: NFkappaB s13 sa8 STOICHIOMETRY ID COMPLEX
component: NFkappaB
component: IkappaB
feature: COMPLEX BINDING FEATURE s99 a124 929
feature: COMPLEX BINDING FEATURE s99 a124 931
cellular location: intracellular

uniprot F6Q0D0 449
type: UnificationXref
id: F6Q0D0
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

Bax inhibitor-1 family protein
type: ProteinReference
xref: uniprot F4JP81 267
organism: Arabidopsis thaliana

uniprot A0A0R4IKK9 220
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

uniprot H2QS79 638
type: UnificationXref
id: H2QS79
db: uniprot

uniprot F6Z1G9 750
type: UnificationXref
id: F6Z1G9
db: uniprot

uniprot P31751 68
type: UnificationXref
id: P31751
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot F7H1B9 756
organism: Macaca mulatta

uniprot P45985 111
type: UnificationXref
id: P45985
db: uniprot

uniprot F1Q3M8 568
type: UnificationXref
id: F1Q3M8
db: uniprot

uniprot F6WX28 651
type: UnificationXref
id: F6WX28
db: uniprot

MAP kinase activating death domain
type: ProteinReference
xref: uniprot E2QTJ4 115
xref: PTHR13008:SF7
organism: Canis lupus familiaris

Granzyme B
type: ProteinReference
xref: P00265
comment: ENTITY_REFERENCE_NOTES=Long Name: Granzyme B Synonym: CGL1,CTLA1,Cathepsin G-like 1,Cytotoxic T-Lymphocyte-associated serine esterase 1,GZMB Accession: P00265
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Granzyme B
member entity reference: Granzyme B
member entity reference: Granzyme B(G,H)
member entity reference: Granzyme H

PARTICIPANT STOICHIOMETRY r66 1041
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 1042
type: Stoichiometry
physical entity: a127_degraded
stoichiometric coefficient: 1.0

Bak
type: Protein
entity reference: Bak
feature: ACTIVE 25
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

uniprot Q9I8I2 88
type: UnificationXref
id: Q9I8I2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Q0D0 449
xref: PTHR23351:SF23
organism: Monodelphis domestica

uniprot Q9XTG7 80
type: UnificationXref
id: Q9XTG7
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Smac_Diablo-RIGHT__Smac_Diablo-_r37
controller: Bak

Fos
type: ProteinReference
xref: P00317
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Fos
comment: ENTITY_REFERENCE_NOTES=
member entity reference: C-fos
member entity reference: V-fos FBJ murine osteosarcoma viral oncogene homolog
member entity reference: Proto-oncogene c-Fos
member entity reference: Uncharacterized protein
member entity reference: FBJ murine osteosarcoma viral oncogene homolog
member entity reference: Fos proto-oncogene, AP-1 transcription factor subunit

Cation-independent mannose-6-phosphate receptor
type: ProteinReference
xref: uniprot P08169 302
xref: PTHR15071:SF17
organism: Bos taurus

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot P20029 792
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NXP6 418
xref: PTHR10454:SF162
organism: Gallus gallus

uniprot G2HHW9 397
type: UnificationXref
id: G2HHW9
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot Q29537 219
organism: Canis lupus familiaris

ATF
type: Protein
entity reference: ATF
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Tumor necrosis factor receptor superfamily member 10C
type: ProteinReference
xref: uniprot O14798 263
organism: Homo sapiens

uniprot O70337 27
type: UnificationXref
id: O70337
db: uniprot

uniprot E2RCV1 566
type: UnificationXref
id: E2RCV1
db: uniprot

uniprot P34885 693
type: UnificationXref
id: P34885
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot F7EJM9 848
organism: Ornithorhynchus anatinus

uniprot H2QW34 620
type: UnificationXref
id: H2QW34
db: uniprot

uniprot D3ZHL6 127
type: UnificationXref
id: D3ZHL6
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Bid-RIGHT__Bid-_r28
control type: INHIBITION
controller: Bcl-2

uniprot P38091 862
type: UnificationXref
id: P38091
db: uniprot

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot E2RNA9 616
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__Bcl_xL-RIGHT__Bcl_xL-_re78
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 1078
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 1079
left: Bcl-xL
interaction type: STATE_TRANSITION
right: Bcl-xL

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

Fas cell surface death receptor
type: ProteinReference
xref: uniprot A0A2I3TG87 345
organism: Pan troglodytes

uniprot A8J5T0 843
type: UnificationXref
id: A8J5T0
db: uniprot

FASLG isoform 1
type: ProteinReference
xref: uniprot H2Q0M2 888
xref: PTHR11471:SF33
organism: Pan troglodytes

uniprot H2RF71 761
type: UnificationXref
id: H2RF71
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot H2QC53 212
organism: Pan troglodytes

Tumor necrosis factor receptor superfamily member 10B
type: ProteinReference
xref: uniprot O14763 262
xref: PTHR46330:SF1
organism: Homo sapiens

TRANSPORT_LEFT__P53-RIGHT__P53-_r120
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r120 998
participant stoichiometry: PARTICIPANT STOICHIOMETRY r120 997
left: P53
interaction type: TRANSPORT
right: P53

uniprot Q8IB24 830
type: UnificationXref
id: Q8IB24
db: uniprot

uniprot H2QJ21 294
type: UnificationXref
id: H2QJ21
db: uniprot

uniprot O88843 372
type: UnificationXref
id: O88843
db: uniprot

uniprot A8XUK9 124
type: UnificationXref
id: A8XUK9
db: uniprot

uniprot F1MXH6 207
type: UnificationXref
id: F1MXH6
db: uniprot

uniprot P63085 168
type: UnificationXref
id: P63085
db: uniprot

uniprot O15111 622
type: UnificationXref
id: O15111
db: uniprot

BIRC2 isoform 11
type: ProteinReference
xref: uniprot H2Q4M6 97
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Cytochrome_C-RIGHT__Cytochrome_C-_r26
controller: Bax

uniprot Q95KV1 626
type: UnificationXref
id: Q95KV1
db: uniprot

FAS-associated death domain protein
type: ProteinReference
xref: PTHR15077:SF9
xref: uniprot Q61160 895
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot F6RA79 668
organism: Monodelphis domestica

Mitogen-activated protein kinase kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q61161 136
organism: Mus musculus

STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1063
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1062
left: AKT
interaction type: STATE_TRANSITION
right: AKT

uniprot A0A3Q1NH21 49
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

uniprot P32871 584
type: UnificationXref
id: P32871
db: uniprot

uniprot F7H1B9 756
type: UnificationXref
id: F7H1B9
db: uniprot

PTHR23351:SF4
type: RelationshipXref
id: PTHR23351:SF4
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK1-RIGHT__MEKK1-_r70
controller: GCK

uniprot Q04861 407
type: UnificationXref
id: Q04861
db: uniprot

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot P63018 805
organism: Rattus norvegicus

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: PTHR19375:SF379
xref: uniprot P63017 804
organism: Mus musculus

uniprot P54652 803
type: UnificationXref
id: P54652
db: uniprot

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Bid-RIGHT__Bid-_r28
controller: Caspase 8

Blk
type: ProteinReference
xref: P00290
standard name: Bcl-2 interacting killer
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Bik-like killer protein Synonym: Synonym not specified Accession: P00290
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Blk
member entity reference: BCL2-interacting killer
member entity reference: Bcl-2-interacting killer

uniprot Q640U4 874
type: UnificationXref
id: Q640U4
db: uniprot

Bim
type: ProteinReference
xref: P00325
comment: ENTITY_REFERENCE_NOTES=Long Name: Bim Synonym: Bcl2 interacting protein,Bcl2-like 11 Accession: P00325
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bim
member entity reference: Bcl-2-like protein 11
member entity reference: BCL2 like 11

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9LMM5 189
xref: PTHR24055:SF439
organism: Arabidopsis thaliana

uniprot P51742 39
type: UnificationXref
id: P51742
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11256:SF48
xref: uniprot F7G9S0 85
organism: Monodelphis domestica

Complex (Bcl-2/Bik)
type: Complex
component stoichiometry: Bcl 2 s20 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Bik s21 sa18 STOICHIOMETRY ID COMPLEX
component: Bik
component: Bcl-2
feature: COMPLEX BINDING FEATURE s175 a278 955
feature: COMPLEX BINDING FEATURE s175 a278 953
cellular location: intracellular

uniprot Q8WNW7 358
type: UnificationXref
id: Q8WNW7
db: uniprot

uniprot P54673 589
type: UnificationXref
id: P54673
db: uniprot

uniprot O93417 510
type: UnificationXref
id: O93417
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7B5L8 233
xref: PTHR24055:SF172
organism: Ornithorhynchus anatinus

IkappaB
type: Protein
entity reference: IkappaB
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa7 930
feature: IkappaB s12 sa7 rs2
feature: IkappaB s12 sa7 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P55210 429
type: UnificationXref
id: P55210
db: uniprot

uniprot A0A3Q2U4X3 50
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__NFkappaB-_IkappaB-RIGHT__Complex__IkappaB_NFkappaB_-_r64
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1050
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1049
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1051
left: NFkappaB
left: IkappaB
interaction type: HETERODIMER_ASSOCIATION
right: Complex (IkappaB/NFkappaB)

STATE_TRANSITION_LEFT__PKR-RIGHT__PKR-_r115
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r115 1011
participant stoichiometry: PARTICIPANT STOICHIOMETRY r115 1012
left: PKR
interaction type: STATE_TRANSITION
right: PKR

PTHR10454:SF8
type: RelationshipXref
id: PTHR10454:SF8
db: PANTHER Family
relationship type: By Homology

BAG family molecular chaperone regulator 3
type: ProteinReference
xref: uniprot F6R2V4 279
organism: Macaca mulatta

uniprot O88550 428
type: UnificationXref
id: O88550
db: uniprot

uniprot A0A2I3T4Q0 614
type: UnificationXref
id: A0A2I3T4Q0
db: uniprot

uniprot A0A2I3TG87 345
type: UnificationXref
id: A0A2I3TG87
db: uniprot

uniprot P70218 133
type: UnificationXref
id: P70218
db: uniprot

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P04637 214
organism: Homo sapiens

Lymphotoxin-alpha
type: ProteinReference
xref: uniprot P61125 40
organism: Pan troglodytes

uniprot P19120 791
type: UnificationXref
id: P19120
db: uniprot

uniprot P11021 781
type: UnificationXref
id: P11021
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 6

TRANSPORT_LEFT__NFkappaB-RIGHT__NFkappaB-_r61
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1056
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 1057
left: NFkappaB
interaction type: TRANSPORT
right: NFkappaB

uniprot A0A1D5RI29 382
type: UnificationXref
id: A0A1D5RI29
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Bax-_Bak-RIGHT__Complex__Bax_Bak_-_r95
controller: Bi1

uniprot Q2HJ92 296
type: UnificationXref
id: Q2HJ92
db: uniprot

uniprot J9NWV6 885
type: UnificationXref
id: J9NWV6
db: uniprot

Major heat shock 70 kDa protein Aa
type: ProteinReference
xref: uniprot P82910 807
xref: PTHR19375:SF371
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r12
controller: Complex (FADD/TRADD)

IGFR2
type: Protein
entity reference: IGFR2
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q9WTK5 412
type: UnificationXref
id: Q9WTK5
db: uniprot

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: uniprot B1NA68 110
xref: PTHR48013:SF15
organism: Danio rerio

NIK
type: Protein
entity reference: NIK
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Putative apoptosis-inducing factor 1, mitochondrial
type: ProteinReference
xref: uniprot Q9VQ79 329
xref: PTHR43557:SF4
organism: Drosophila melanogaster

Protein A1
type: ProteinReference
xref: PTHR11256:SF10
xref: uniprot Q9W6F2 313
organism: Gallus gallus

Bik
type: ProteinReference
xref: P00258
standard name: Bcl-2 interacting killer
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Bcl-2 interacting killer Synonym: Synonym not specified Accession: P00258
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bik
member entity reference: BCL2-interacting killer
member entity reference: Bcl-2-interacting killer
member entity reference: BCL2 interacting killer

uniprot P47197 70
type: UnificationXref
id: P47197
db: uniprot

ATF3 isoform 2
type: ProteinReference
xref: uniprot K7D430 467
xref: PTHR23351:SF23
organism: Pan troglodytes

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05627 499
organism: Mus musculus

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 538

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q9DGD9 249
organism: Danio rerio

ncbitaxon 9258 84
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot P36415 800
type: UnificationXref
id: P36415
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19304:SF10
xref: uniprot E2RIE0 443
organism: Canis lupus familiaris

uniprot E2RNA9 616
type: UnificationXref
id: E2RNA9
db: uniprot

FAS ligand s61 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAS ligand
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase kinase 4
type: ProteinReference
xref: uniprot A0A0G2K7W4 598
organism: Rattus norvegicus

uniprot Q8BPM2 137
type: UnificationXref
id: Q8BPM2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK7-RIGHT__MKK7-_r71
controller: ASK1

uniprot Q9LKR3 840
type: UnificationXref
id: Q9LKR3
db: uniprot

Granzyme B
type: ProteinReference
xref: uniprot P18291 108
organism: Rattus norvegicus

uniprot Q9R0I6 507
type: UnificationXref
id: Q9R0I6
db: uniprot

uniprot Q00653 403
type: UnificationXref
id: Q00653
db: uniprot

NIK
type: ProteinReference
xref: P00324
standard name: NF kappa B inducing kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: NF kappa B inducing kinase Synonym: HSNIK,MAPKKK 14,Mitogen activated protein kinase kinase kinase 14 Accession: P00324
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.NIK
member entity reference: Mitogen-activated protein kinase kinase kinase 14
member entity reference: MAP3K14 isoform 1

Uncharacterized protein
type: ProteinReference
xref: PTHR11961:SF29
xref: uniprot F7GTP8 850
organism: Macaca mulatta

uniprot A5D7R0 346
type: UnificationXref
id: A5D7R0
db: uniprot

uniprot Q62925 366
type: UnificationXref
id: Q62925
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK3-RIGHT__MKK3-_r68
controller: ASK1

Complex (FAS/DAXX/ FADD/FAS ligand)
type: Complex
component stoichiometry: FADD s64 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: DAXX s63 sa34 STOICHIOMETRY ID COMPLEX
component stoichiometry: FAS ligand s65 sa36 STOICHIOMETRY ID COMPLEX
component: DAXX
component: FAS
component: FADD
component: FAS ligand
feature: COMPLEX BINDING FEATURE s214 a350 909
feature: COMPLEX BINDING FEATURE s214 a350 907
feature: ACTIVE 25
feature: COMPLEX BINDING FEATURE s214 a350 911
feature: COMPLEX BINDING FEATURE s214 a350 905
cellular location: intracellular

Cytochrome c-1
type: ProteinReference
xref: uniprot P04657 860
organism: Drosophila melanogaster

uniprot O35451 468
type: UnificationXref
id: O35451
db: uniprot

uniprot Q06600 42
type: UnificationXref
id: Q06600
db: uniprot

uniprot P11147 784
type: UnificationXref
id: P11147
db: uniprot

uniprot Q99558 881
type: UnificationXref
id: Q99558
db: uniprot

ASK1 s230 a129 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O35904 583
xref: PTHR10048:SF35
organism: Mus musculus

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 540

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot F7HC75 673
organism: Macaca mulatta

uniprot A0A2I3TJU8 414
type: UnificationXref
id: A0A2I3TJU8
db: uniprot

uniprot G1K268 757
type: UnificationXref
id: G1K268
db: uniprot

CASP8 and FADD-like apoptosis regulator
type: ProteinReference
xref: PTHR10454:SF8
xref: uniprot A0A2I3SPU3 314
organism: Pan troglodytes

TNFR1 s27 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TNFR1
stoichiometric coefficient: 3.0

Heat shock 70kDa protein
type: ProteinReference
xref: uniprot A9JTJ5 723
xref: PTHR19375:SF388
organism: Xenopus tropicalis

Nuclear factor kappaB subunit p65
type: ProteinReference
xref: uniprot Q7TQN4 411
xref: PTHR24169:SF1
organism: Rattus norvegicus

uniprot F7G3I5 576
type: UnificationXref
id: F7G3I5
db: uniprot

PTHR24169:SF1
type: RelationshipXref
id: PTHR24169:SF1
db: PANTHER Family
relationship type: By Homology

Complex (TRADD/RAIDD/ TRAF2/RIP)
type: Complex
component stoichiometry: RAIDD s6 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: RIP s11 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRAF2 s8 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRADD s5 sa3 STOICHIOMETRY ID COMPLEX
component: TRAF2
component: RAIDD
component: RIP
component: TRADD
feature: COMPLEX BINDING FEATURE s74 a97 967
feature: COMPLEX BINDING FEATURE s74 a97 965
feature: COMPLEX BINDING FEATURE s74 a97 963
feature: COMPLEX BINDING FEATURE s74 a97 961
feature: ACTIVE 25
cellular location: intracellular

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q90593 834
organism: Gallus gallus

uniprot A0A0D1C4Y4 138
type: UnificationXref
id: A0A0D1C4Y4
db: uniprot

Bak s19 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Bak
stoichiometric coefficient: 1.0

uniprot H2Q2N9 281
type: UnificationXref
id: H2Q2N9
db: uniprot

PTHR24169:SF9
type: RelationshipXref
id: PTHR24169:SF9
db: PANTHER Family
relationship type: By Homology

NIK
type: Protein
entity reference: NIK
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR24169:SF4
type: RelationshipXref
id: PTHR24169:SF4
db: PANTHER Family
relationship type: By Homology

Bax
type: Protein
entity reference: Bax
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa15 898
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

DIABLO isoform 1
type: ProteinReference
xref: uniprot K7CIS5 554
organism: Pan troglodytes

STATE_TRANSITION
type: RelationshipTypeVocabulary

Smac/Diablo
type: ProteinReference
xref: P00309
standard name: Second mitochondria-derived activator of caspase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Second mitochondria-derived activator of caspase Synonym: Diablo,Direct IAP-binding protein with low PI,Smac Accession: P00309
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Smac/Diablo
member entity reference: Kelch-like protein diablo
member entity reference: Diablo homolog, mitochondrial
member entity reference: Diablo IAP-binding mitochondrial protein
member entity reference: Diablo-like
member entity reference: DIABLO isoform 1
member entity reference: Diablo homolog (Drosophila)

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 188

Apoptotic protease-activating factor 1
type: ProteinReference
xref: uniprot H2R1S6 432
xref: PTHR22845:SF5
organism: Pan troglodytes

MODULATION
type: Control
xref: MODULATION
controlled: Pro-apoptotic
controller: Complex (Fos/c-Jun)

Caspase 10
type: Protein
entity reference: Caspase 10
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot I0FPK1 377
type: UnificationXref
id: I0FPK1
db: uniprot

Receptor-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: PTHR44329:SF6
xref: uniprot Q13546 639
organism: Homo sapiens

ATF6 isoform 1
type: ProteinReference
xref: uniprot H2Q0H3 462
xref: PTHR46164:SF1
organism: Pan troglodytes

Eukaryotic translation initiation factor 2 subunit 1
type: ProteinReference
xref: uniprot P68101 529
xref: PTHR10602:SF0
organism: Rattus norvegicus

uniprot H2PXY8 579
type: UnificationXref
id: H2PXY8
db: uniprot

Eukaryotic translation initiation factor 2 subunit 1
type: ProteinReference
xref: PTHR10602:SF0
xref: uniprot P68102 530
organism: Bos taurus

ncbitaxon 44689 590
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot Q6P3L3 822
type: UnificationXref
id: Q6P3L3
db: uniprot

BCL2 like 10
type: ProteinReference
xref: PTHR11256:SF47
xref: uniprot H2Q9G4 319
organism: Pan troglodytes

Eukaryotic translation initiation factor 2 subunit 1
type: ProteinReference
xref: uniprot F7EFD7 523
organism: Macaca mulatta

Mitogen-activated protein kinase mpk-1
type: ProteinReference
xref: uniprot P39745 167
xref: PTHR24055:SF158
organism: Caenorhabditis elegans

uniprot A0A3Q2TVK8 439
type: UnificationXref
id: A0A3Q2TVK8
db: uniprot

uniprot Q64617 703
type: UnificationXref
id: Q64617
db: uniprot

uniprot H2Q867 355
type: UnificationXref
id: H2Q867
db: uniprot

Heat shock protein 70 putative
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot C4M3S5 733
organism: Entamoeba histolytica

Probable heat shock protein ssa2
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot O59855 768
organism: Schizosaccharomyces pombe

Transmembrane BAX inhibitor motif containing 6
type: ProteinReference
xref: uniprot E2QY18 266
organism: Canis lupus familiaris

Si:dkey-4p15.3
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot F1R9V3 741
organism: Danio rerio

uniprot P23298 689
type: UnificationXref
id: P23298
db: uniprot

ncbitaxon 237561 179
type: UnificationXref
id: 237561
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r26 972
type: Stoichiometry
physical entity: Cytochrome C
stoichiometric coefficient: 1.0

DAXX
type: ProteinReference
xref: P00296
standard name: Death-associated protein 6
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.DAXX
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Death-associated protein 6 Synonym: Synonym not specified Accession: P00296
member entity reference: Death domain-associated protein 6
member entity reference: DAXX isoform 1
member entity reference: Death domain-associated protein 6 isoform a

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q8UUX0 78
organism: Danio rerio

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 125

PARTICIPANT STOICHIOMETRY r26 971
type: Stoichiometry
physical entity: Cytochrome C
stoichiometric coefficient: 1.0

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 72

ncbitaxon 9606 18
type: UnificationXref
id: 9606
db: ncbitaxon

Major heat shock 70 kDa protein Bbb
type: ProteinReference
xref: PTHR19375:SF371
xref: uniprot Q9VG58 842
organism: Drosophila melanogaster

Pristionchus pacificus
type: BioSource
xref: ncbitaxon 54126 763

uniprot H2Q8A0 132
type: UnificationXref
id: H2Q8A0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QG41 711
xref: PTHR12329:SF10
organism: Macaca mulatta

uniprot F6ZV71 200
type: UnificationXref
id: F6ZV71
db: uniprot

uniprot Q7QK56 74
type: UnificationXref
id: Q7QK56
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q8BTI9 595
organism: Mus musculus

uniprot F6THC2 637
type: UnificationXref
id: F6THC2
db: uniprot

TNFRSF1A-associated via death domain
type: ProteinReference
xref: uniprot D3ZZC5 705
organism: Rattus norvegicus

uniprot F7EJM9 848
type: UnificationXref
id: F7EJM9
db: uniprot

P53
type: Protein
entity reference: P53
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

TRADD s5 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRADD
stoichiometric coefficient: 1.0

uniprot Q9BDP2 350
type: UnificationXref
id: Q9BDP2
db: uniprot

uniprot Q7Q6L7 273
type: UnificationXref
id: Q7Q6L7
db: uniprot

Bag
type: ProteinReference
xref: P00278
standard name: Bcl-2 associated anthogene-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bag
comment: ENTITY_REFERENCE_NOTES=Long Name: Bcl-2 associated anthogene-1 Synonym: Bcl2- associated athanogen 1 Accession: P00278
member entity reference: BAG family molecular chaperone regulator 3
member entity reference: BAG3 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Bcl2-associated athanogene 3
member entity reference: BAG family molecular chaperone regulator 1

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 147
organism: Canis lupus familiaris

uniprot F7DGQ2 315
type: UnificationXref
id: F7DGQ2
db: uniprot

Complex (FADD/TRADD)
type: Complex
component stoichiometry: FADD s2 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRADD s3 sa2 STOICHIOMETRY ID COMPLEX
component: FADD
component: TRADD
feature: COMPLEX BINDING FEATURE s70 a89 923
feature: ACTIVE 25
feature: COMPLEX BINDING FEATURE s70 a89 921
cellular location: intracellular

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot O09110 635
organism: Mus musculus

uniprot P29844 798
type: UnificationXref
id: P29844
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Anti-apoptosis
controller: NFkappaB

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P32871 584
organism: Bos taurus

uniprot O14733 611
type: UnificationXref
id: O14733
db: uniprot

Transcription factor RelB
type: ProteinReference
xref: uniprot Q01201 404
organism: Homo sapiens

NFKB inhibitor alpha
type: ProteinReference
xref: uniprot E2RML9 354
xref: PTHR46680:SF1
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__c_IAP1,2-RIGHT__c_IAP1,2-_r103
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 1053
participant stoichiometry: PARTICIPANT STOICHIOMETRY r103 1052
left: c-IAP1,2
interaction type: STATE_TRANSITION
right: c-IAP1,2

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

uniprot O02703 202
type: UnificationXref
id: O02703
db: uniprot

uniprot P63318 694
type: UnificationXref
id: P63318
db: uniprot

uniprot F6XFE0 749
type: UnificationXref
id: F6XFE0
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot E1BE66 565
xref: PTHR10048:SF35
organism: Bos taurus

uniprot Q61831 246
type: UnificationXref
id: Q61831
db: uniprot

PARTICIPANT STOICHIOMETRY r113 1017
type: Stoichiometry
physical entity: Caspase 10
stoichiometric coefficient: 1.0

TRAIL-R
type: Protein
entity reference: TRAIL-R
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r113 1018
type: Stoichiometry
physical entity: Caspase 10
stoichiometric coefficient: 1.0

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r54
control type: INHIBITION
controller: Flip

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r105
control type: INHIBITION
controller: c-IAP1,2

Apoptosis regulator Bcl-2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot Q00709 199
organism: Gallus gallus

uniprot P67881 866
type: UnificationXref
id: P67881
db: uniprot

Caspase 7
type: ProteinReference
xref: P00300
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase 7 Synonym: Cysteinyl aspartic acid-protease-7 Accession: P00300
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Caspase 7
member entity reference: Caspase-7
member entity reference: Caspase 7, isoform CRA_c
member entity reference: Caspase 7
member entity reference: Uncharacterized protein
member entity reference: CASP7 isoform 1

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot Q99170 836
organism: Yarrowia lipolytica

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot C8V7D1 144
xref: PTHR24055:SF158
organism: Emericella nidulans

uniprot E2QX84 735
type: UnificationXref
id: E2QX84
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q60823 73
organism: Mus musculus

uniprot Q9Z1L0 597
type: UnificationXref
id: Q9Z1L0
db: uniprot

uniprot Q8INB9 76
type: UnificationXref
id: Q8INB9
db: uniprot

Caspase 9
type: ProteinReference
xref: P00298
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Caspase 9
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase 9 Synonym: Cysteinyl aspartic acid-protease-9 Accession: P00298
member entity reference: CASP9 isoform 4
member entity reference: Caspase 9, isoform CRA_a
member entity reference: Caspase-9
member entity reference: Uncharacterized protein

uniprot Q39043 814
type: UnificationXref
id: Q39043
db: uniprot

Protein CBR-HSP-1
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot A8WN50 720
organism: Caenorhabditis briggsae

uniprot H2QPY8 398
type: UnificationXref
id: H2QPY8
db: uniprot

uniprot F1PCQ4 447
type: UnificationXref
id: F1PCQ4
db: uniprot

Diablo-like
type: ProteinReference
xref: PTHR32247:SF3
xref: uniprot D4A7Z5 553
organism: Rattus norvegicus

Major heat shock 70 kDa protein Ba
type: ProteinReference
xref: PTHR19375:SF371
xref: uniprot Q8INI8 832
organism: Drosophila melanogaster

uniprot H2RC20 880
type: UnificationXref
id: H2RC20
db: uniprot

Bik
type: Protein
entity reference: Bik
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F1LQH2 389
type: UnificationXref
id: F1LQH2
db: uniprot

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot Q23290 135
organism: Caenorhabditis elegans

Lymphotoxin-beta
type: ProteinReference
xref: uniprot Q862Z7 47
xref: PTHR11471:SF29
organism: Pan troglodytes

Inhibitor of apoptosis protein 3
type: ProteinReference
xref: uniprot Q8UVF8 506
organism: Gallus gallus

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P12841 656
xref: PTHR23351:SF4
organism: Rattus norvegicus

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P45985 111
organism: Homo sapiens

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 239
xref: PTHR24055:SF222
organism: Homo sapiens

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P45984 240
xref: PTHR24055:SF172
organism: Homo sapiens

uniprot A8Y1C9 722
type: UnificationXref
id: A8Y1C9
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: TRANSPORT_LEFT__AIF-RIGHT__AIF-_r36
control type: INHIBITION
controller: HSP70

Baculoviral IAP repeat-containing protein 3
type: ProteinReference
xref: PTHR10044:SF99
xref: uniprot Q13489 99
organism: Homo sapiens

uniprot P25445 347
type: UnificationXref
id: P25445
db: uniprot

uniprot P98170 504
type: UnificationXref
id: P98170
db: uniprot

PARTICIPANT STOICHIOMETRY r73 1019
type: Stoichiometry
physical entity: SEK1
stoichiometric coefficient: 1.0

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

uniprot Q63690 205
type: UnificationXref
id: Q63690
db: uniprot

TNF receptor-associated factor
type: ProteinReference
xref: uniprot H2QY73 516
xref: PTHR10131:SF21
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r73 1020
type: Stoichiometry
physical entity: SEK1
stoichiometric coefficient: 1.0

uniprot P92208 245
type: UnificationXref
id: P92208
db: uniprot

uniprot B8BWB9 731
type: UnificationXref
id: B8BWB9
db: uniprot

Eukaryotic translation initiation factor 2 subunit 1
type: ProteinReference
xref: uniprot P05198 525
organism: Homo sapiens

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF466
xref: uniprot Q9M1Z5 191
organism: Arabidopsis thaliana

Mitogen-activated protein kinase kinase kinase 14
type: ProteinReference
xref: uniprot Q99558 881
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RDI1 299
xref: PTHR15071:SF17
organism: Macaca mulatta

uniprot A0A2J8NYK5 376
type: UnificationXref
id: A0A2J8NYK5
db: uniprot

Heat shock protein 68
type: ProteinReference
xref: PTHR19375:SF431
xref: uniprot O97125 770
organism: Drosophila melanogaster

uniprot E1BJH5 599
type: UnificationXref
id: E1BJH5
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F7BIC2 670
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r50
controller: Caspase 8

uniprot P16892 161
type: UnificationXref
id: P16892
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r72
controller: SEK1

uniprot P47196 69
type: UnificationXref
id: P47196
db: uniprot

STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r113
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 1018
participant stoichiometry: PARTICIPANT STOICHIOMETRY r113 1017
left: Caspase 10
interaction type: STATE_TRANSITION
right: Caspase 10

ATF4
type: ProteinReference
xref: uniprot Q9W610 494
xref: PTHR13044:SF2
organism: Gallus gallus

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05129 681
organism: Homo sapiens

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05126 679
xref: PTHR24356:SF158
organism: Bos taurus

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05128 680
organism: Bos taurus

Receptor-interacting serine/threonine-protein kinase 1
type: ProteinReference
xref: uniprot Q60855 640
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F6QE96 56
organism: Macaca mulatta

uniprot H2QVW0 260
type: UnificationXref
id: H2QVW0
db: uniprot

Apoptosis regulator Bcl-2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot O02718 195
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F1PRG4 54
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__IkappaB-RIGHT__IkappaB-_r65
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 1045
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 1046
left: IkappaB
interaction type: STATE_TRANSITION
right: IkappaB

Heat Shock Protein
type: ProteinReference
xref: PTHR19375:SF207
xref: uniprot O45246 767
organism: Caenorhabditis elegans

Smac/Diablo
type: Protein
entity reference: Smac/Diablo
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 688
organism: Mus musculus

STATE_TRANSITION_LEFT__IkappaB-RIGHT__IkappaB-_r60
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1058
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 1059
left: IkappaB
interaction type: STATE_TRANSITION
right: IkappaB

HSP70
type: ProteinReference
xref: P00321
standard name: Heat shock protein 70
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.HSP70
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Heat shock protein 70 Synonym: Synonym not specified Accession: P00321
member entity reference: Uncharacterized protein
member entity reference: Endoplasmic reticulum chaperone BiP
member entity reference: Heat shock 70 kDa protein A
member entity reference: Heat shock protein SSA1
member entity reference: Heat shock protein SSA4
member entity reference: Heat shock cognate 71 kDa protein
member entity reference: AGAP004192-PA
member entity reference: Heat shock 70 kDa protein cognate 2
member entity reference: Heat shock 70 kDa protein 5
member entity reference: Heat shock 70 kDa protein 18
member entity reference: AGAP004581-PA
member entity reference: Heat shock protein 70
member entity reference: Heat shock protein family A (Hsp70) member 6
member entity reference: Heat shock 70 kDa protein C
member entity reference: Heat shock protein
member entity reference: Si:dkey-4p15.3
member entity reference: Predicted protein
member entity reference: Heat shock 70 kDa protein 3
member entity reference: Protein CBG13234
member entity reference: 70 kDa heat shock protein
member entity reference: Heat shock protein 68
member entity reference: DNA helicase
member entity reference: Heat shock protein family A (Hsp70) member 2
member entity reference: Probable heat shock protein ssa2
member entity reference: Heat shock protein family A (Hsp70) member 5
member entity reference: Heat shock 70 kDa protein 1A
member entity reference: AGAP004944-PA
member entity reference: Heat Shock Protein
member entity reference: Heat shock 70 kDa protein cognate 4
member entity reference: Probable heat shock protein ssa1
member entity reference: Heat shock protein/chaperone
member entity reference: Heat shock cognate 70-kd protein, tandem duplicate 3
member entity reference: Heat shock-related 70 kDa protein 2
member entity reference: Heat shock 70 kDa protein 1-like
member entity reference: Heat shock 70 kDa protein BIP2
member entity reference: Heat shock 70kDa protein
member entity reference: Heat shock protein SSA2
member entity reference: Heat shock cognate 70-kd protein,-like
member entity reference: Probable mediator of RNA polymerase II transcription subunit 37b
member entity reference: DnaK-type molecular chaperone hsp70-rice
member entity reference: Heat shock 70 kDa protein cognate 1
member entity reference: 78 kDa glucose-regulated protein
member entity reference: Heat shock protein family A (Hsp70) member 1A

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r58
controller: NIK

ncbitaxon 39947 171
type: UnificationXref
id: 39947
db: ncbitaxon

Bax inhibitor 1
type: ProteinReference
xref: uniprot P55061 270
organism: Homo sapiens

Bax inhibitor 1
type: ProteinReference
xref: uniprot P55062 271
organism: Rattus norvegicus

PTHR24169:SF18
type: RelationshipXref
id: PTHR24169:SF18
db: PANTHER Family
relationship type: By Homology

Protein kinase C, brain isozyme
type: ProteinReference
xref: uniprot P05130 682
xref: PTHR24356:SF390
organism: Drosophila melanogaster

TNFR1
type: Protein
entity reference: TNFR1

Complex (Bax/Bak)
type: Complex
component stoichiometry: Bax s18 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: Bak s19 sa16 STOICHIOMETRY ID COMPLEX
component: Bak
component: Bax
feature: COMPLEX BINDING FEATURE s174 a275 899
feature: COMPLEX BINDING FEATURE s174 a275 897
cellular location: intracellular

Mitogen-activated protein kinase spk1
type: ProteinReference
xref: uniprot P27638 164
xref: PTHR24055:SF158
organism: Schizosaccharomyces pombe

IkappaB s101 a127 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Apaf_1-RIGHT__Apaf_1-_r101
controller: Cytochrome C

Baculoviral IAP repeat-containing protein 2
type: ProteinReference
xref: uniprot Q13490 100
organism: Homo sapiens

uniprot Q8H1B3 829
type: UnificationXref
id: Q8H1B3
db: uniprot

PTHR43557:SF4
type: RelationshipXref
id: PTHR43557:SF4
db: PANTHER Family
relationship type: By Homology

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 532

MAP3K14 isoform 1
type: ProteinReference
xref: uniprot H2RC20 880
xref: PTHR48016:SF9
organism: Pan troglodytes

ncbitaxon 284591 837
type: UnificationXref
id: 284591
db: ncbitaxon

ncbitaxon 10090 20
type: UnificationXref
id: 10090
db: ncbitaxon

PTHR24169:SF21
type: RelationshipXref
id: PTHR24169:SF21
db: PANTHER Family
relationship type: By Homology

Eukaryotic translation initiation factor 2 subunit alpha
type: ProteinReference
xref: uniprot P20459 526
organism: Saccharomyces cerevisiae

uniprot P39429 518
type: UnificationXref
id: P39429
db: uniprot

uniprot F6PXH5 632
type: UnificationXref
id: F6PXH5
db: uniprot

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: uniprot F1LQH2 389
xref: PTHR24169:SF9
organism: Rattus norvegicus

Bik s21 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Bik
stoichiometric coefficient: 1.0

uniprot P54675 592
type: UnificationXref
id: P54675
db: uniprot

Bok
type: Protein
entity reference: Bok
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P20163 793
type: UnificationXref
id: P20163
db: uniprot

NFKB1 isoform 1
type: ProteinReference
xref: uniprot H2QPY8 398
xref: PTHR24169:SF9
organism: Pan troglodytes

MAP kinase-activating death domain protein
type: ProteinReference
xref: PTHR13008:SF7
xref: uniprot O08873 117
organism: Rattus norvegicus

uniprot H2R7H0 760
type: UnificationXref
id: H2R7H0
db: uniprot

IkappaB s101 a127 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=1.9622796218629746
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

FAS s60 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAS
stoichiometric coefficient: 3.0

uniprot P19838 401
type: UnificationXref
id: P19838
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot K7CDC2 65
organism: Pan troglodytes

uniprot E1BMG4 662
type: UnificationXref
id: E1BMG4
db: uniprot

STATE_TRANSITION_LEFT__IkappaB-RIGHT__a127_degraded-_r66
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 1041
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 1042
left: IkappaB
interaction type: STATE_TRANSITION
right: a127_degraded

Uncharacterized protein
type: ProteinReference
xref: uniprot G1K372 851
xref: PTHR11961:SF29
organism: Macaca mulatta

Fos s14 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fos
stoichiometric coefficient: 1.0

uniprot Q4Q7Y4 815
type: UnificationXref
id: Q4Q7Y4
db: uniprot

uniprot Q9HRT8 543
type: UnificationXref
id: Q9HRT8
db: uniprot

Baculoviral IAP repeat-containing protein 3
type: ProteinReference
xref: uniprot O08863 98
organism: Mus musculus

uniprot P05130 682
type: UnificationXref
id: P05130
db: uniprot

Apoptosis regulator BAX
type: ProteinReference
xref: uniprot O02703 202
xref: PTHR11256:SF42
organism: Bos taurus

RAIDD
type: ProteinReference
xref: P00294
standard name: RIP associated ICH-1/CED homologous protein with death domain
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: RIP associated ICH-1/CED homologous protein with death domain Synonym: CRADD,Casp2 and RIPK1 domain-containing adaptor with death domain,Caspase and RIP adaptor with death domain Accession: P00294
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.RAIDD
member entity reference: Death domain-containing protein CRADD
member entity reference: Caspase and RIP adapter
member entity reference: CASP2 and RIPK1 domain containing adaptor with death domain

CASP9 isoform 4
type: ProteinReference
xref: PTHR10454:SF157
xref: uniprot A0A2I3TJU8 414
organism: Pan troglodytes

Probable heat shock protein ssa1
type: ProteinReference
xref: uniprot Q10265 809
xref: PTHR19375:SF426
organism: Schizosaccharomyces pombe

MADD
type: ProteinReference
xref: P00267
standard name: Mitogen activated protein kinase activating death domain
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.MADD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen activated protein kinase activating death domain Synonym: DENN Accession: P00267
member entity reference: MAP kinase activating death domain
member entity reference: MAP kinase-activating death domain protein
member entity reference: MADD isoform 3
member entity reference: Uncharacterized protein

Bak
type: ProteinReference
xref: P00275
standard name: Bcl-2 antogonist/killer
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bak
comment: ENTITY_REFERENCE_NOTES=Long Name: Bcl-2 antogonist/killer Synonym: Synonym not specified Accession: P00275
member entity reference: BAK1 isoform 3
member entity reference: Bcl-2 homologous antagonist/killer
member entity reference: BAK protein

uniprot O44408 238
type: UnificationXref
id: O44408
db: uniprot

MAPK s105 a131 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Fos
type: Protein
entity reference: Fos
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa11 918
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MODULATION
type: Control
xref: MODULATION
controlled: Pro-apoptotic
controller: Caspase 3

uniprot Q39021 172
type: UnificationXref
id: Q39021
db: uniprot

TRADD
type: Protein
entity reference: TRADD
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa3 962
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F6QA46 450
type: UnificationXref
id: F6QA46
db: uniprot

Heat shock-related 70 kDa protein 2
type: ProteinReference
xref: uniprot P17156 789
xref: PTHR19375:SF382
organism: Mus musculus

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P10361 215
organism: Rattus norvegicus

MODULATION
type: Control
xref: MODULATION
controlled: Pro-apoptotic
controller: Caspase 3

MODULATION
type: Control
xref: MODULATION
controlled: Pro-apoptotic
controller: Caspase 3

IDA
type: EvidenceCodeVocabulary

Death domain-associated protein 6 isoform a
type: ProteinReference
xref: uniprot I0FPK1 377
xref: PTHR12766:SF7
organism: Macaca mulatta

Eukaryotic translation initiation factor 2, subunit 1 alpha
type: ProteinReference
xref: PTHR10602:SF0
xref: uniprot Q9I9E9 545
organism: Danio rerio

BCL2-associated X protein
type: ProteinReference
xref: uniprot Q6P4Y4 206
xref: PTHR11256:SF42
organism: Xenopus tropicalis

STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r53
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 1071
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 1070
left: Caspase 8
interaction type: STATE_TRANSITION
right: Caspase 8

Bax inhibitor 1
type: ProteinReference
xref: uniprot Q9MBD8 276
organism: Oryza sativa

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 168
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: PTHR24351:SF182
xref: uniprot F1MDC9 665
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63086 169
organism: Rattus norvegicus

uniprot O14727 433
type: UnificationXref
id: O14727
db: uniprot

Cyclic AMP-dependent transcription factor ATF-7
type: ProteinReference
xref: PTHR19304:SF10
xref: uniprot P17544 473
organism: Homo sapiens

uniprot Q60739 284
type: UnificationXref
id: Q60739
db: uniprot

Transcription factor RelB
type: ProteinReference
xref: PTHR24169:SF18
xref: uniprot Q04863 408
organism: Mus musculus

ncbitaxon 6238 125
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot P00015 855
type: UnificationXref
id: P00015
db: uniprot

uniprot A7UVK8 718
type: UnificationXref
id: A7UVK8
db: uniprot

Proto-oncogene c-Rel
type: ProteinReference
xref: uniprot Q04864 409
organism: Homo sapiens

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P53779 243
xref: PTHR24055:SF162
organism: Homo sapiens

Heat shock 70 kDa protein BIP2
type: ProteinReference
xref: uniprot Q53RJ5 818
xref: PTHR19375:SF442
organism: Oryza sativa

uniprot B1NA68 110
type: UnificationXref
id: B1NA68
db: uniprot

uniprot F6RYL1 496
type: UnificationXref
id: F6RYL1
db: uniprot

Heat shock cognate 70
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot Q6PGX4 823
organism: Danio rerio

uniprot F7CYE3 234
type: UnificationXref
id: F7CYE3
db: uniprot

uniprot F7FHD1 154
type: UnificationXref
id: F7FHD1
db: uniprot

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: uniprot Q04861 407
xref: PTHR24169:SF9
organism: Gallus gallus

NFkappaB
type: Protein
entity reference: NFkappaB
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot A7UT42 717
type: UnificationXref
id: A7UT42
db: uniprot

uniprot A0A1D5Q5Z6 140
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

uniprot B8JK21 508
type: UnificationXref
id: B8JK21
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O23236 157
xref: PTHR24055:SF401
organism: Arabidopsis thaliana

uniprot Q63199 349
type: UnificationXref
id: Q63199
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot A0A1D5R1G4 353
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r60 1058
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r60 1059
type: Stoichiometry
physical entity: IkappaB
stoichiometric coefficient: 1.0

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

PACT
type: Protein
entity reference: PACT
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR10048:SF109
type: RelationshipXref
id: PTHR10048:SF109
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Complex__TNFR1_TNF_-_MADD-RIGHT__Complex__TNFR1_TNF__MADD_-_r127
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 984
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 985
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 983
left: MADD
left: Complex (TNFR1/TNF)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TNFR1/TNF/ MADD)

uniprot Q8ZTY5 539
type: UnificationXref
id: Q8ZTY5
db: uniprot

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: uniprot Q7PVR1 184
xref: PTHR24055:SF158
organism: Anopheles gambiae

uniprot O23138 852
type: UnificationXref
id: O23138
db: uniprot

uniprot O14920 621
type: UnificationXref
id: O14920
db: uniprot

ASK1
type: Protein
entity reference: ASK1
feature: ASK1 s231 a136 rs1
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot A0A452DID2 440
type: UnificationXref
id: A0A452DID2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q1LWJ8 223
organism: Bos taurus

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot Q9QY78 627
organism: Rattus norvegicus

uniprot P22202 794
type: UnificationXref
id: P22202
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q05655 700
organism: Homo sapiens

Cytochrome c
type: ProteinReference
xref: uniprot P67881 866
organism: Gallus gallus

ncbitaxon 227321 145
type: UnificationXref
id: 227321
db: ncbitaxon

GCKR
type: Protein
entity reference: GCKR
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q13233 365
type: UnificationXref
id: Q13233
db: uniprot

STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r86
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 989
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 988
left: Caspase 8
interaction type: STATE_TRANSITION
right: Caspase 8

uniprot H2QAS6 675
type: UnificationXref
id: H2QAS6
db: uniprot

uniprot F6UZ27 746
type: UnificationXref
id: F6UZ27
db: uniprot

uniprot F7F3S0 574
type: UnificationXref
id: F7F3S0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF168
xref: uniprot F6XFE0 749
organism: Monodelphis domestica

uniprot A0A2I3RZL6 323
type: UnificationXref
id: A0A2I3RZL6
db: uniprot

uniprot P00048 859
type: UnificationXref
id: P00048
db: uniprot

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot F1PZN1 600
organism: Canis lupus familiaris

TNF receptor-associated factor
type: ProteinReference
xref: uniprot J9NS71 517
xref: PTHR10131:SF21
organism: Canis lupus familiaris

uniprot Q6PH56 824
type: UnificationXref
id: Q6PH56
db: uniprot

uniprot Q60680 624
type: UnificationXref
id: Q60680
db: uniprot

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q17941 71
organism: Caenorhabditis elegans

E3 ubiquitin-protein ligase XIAP
type: ProteinReference
xref: uniprot P98170 504
organism: Homo sapiens

uniprot Q9SIZ2 546
type: UnificationXref
id: Q9SIZ2
db: uniprot

uniprot P18847 475
type: UnificationXref
id: P18847
db: uniprot

78 kDa glucose-regulated protein
type: ProteinReference
xref: uniprot F7C3R1 752
xref: PTHR19375:SF144
organism: Macaca mulatta

uniprot Q925D2 30
type: UnificationXref
id: Q925D2
db: uniprot

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q63746 357
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK-RIGHT__JNK-_r72
controller: MKK7

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r12
control type: INHIBITION
controller: SODD

ncbitaxon 13616 58
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot A1ZBH7 123
type: UnificationXref
id: A1ZBH7
db: uniprot

STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 1007
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 1008
left: Caspase 8
interaction type: STATE_TRANSITION
right: Caspase 8

GCKR
type: Protein
entity reference: GCKR
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q5PU49 702
type: UnificationXref
id: Q5PU49
db: uniprot

Heat shock cognate 70-kd protein, tandem duplicate 3
type: ProteinReference
xref: uniprot Q6PH56 824
xref: PTHR19375:SF448
organism: Danio rerio

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K344 559
organism: Rattus norvegicus

AGAP004944-PA
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot Q7Q7Y8 827
organism: Anopheles gambiae

PACT
type: Protein
entity reference: PACT
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q80WY6 335
type: UnificationXref
id: Q80WY6
db: uniprot

uniprot Q39023 174
type: UnificationXref
id: Q39023
db: uniprot

Bax inhibitor 1
type: ProteinReference
xref: uniprot Q9D2C7 274
organism: Mus musculus

uniprot Q3V5X8 291
type: UnificationXref
id: Q3V5X8
db: uniprot

Activating transcription factor 1
type: ProteinReference
xref: uniprot F7BRQ2 455
xref: PTHR45879:SF2
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r21 987
type: Stoichiometry
physical entity: GCK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 986
type: Stoichiometry
physical entity: GCK
stoichiometric coefficient: 1.0

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot A8KBH6 660
organism: Xenopus tropicalis

Mitogen-activated protein kinase kinase kinase 14
type: ProteinReference
xref: uniprot Q9WUL6 882
organism: Mus musculus

uniprot P34722 692
type: UnificationXref
id: P34722
db: uniprot

MKK7 s108 a134 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TRAIL
type: ProteinReference
xref: P00263
standard name: TNF-related apoptosis inducing ligand
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.TRAIL
comment: ENTITY_REFERENCE_NOTES=Long Name: TNF-related apoptosis inducing ligand Synonym: APO2 ligand,APO2L Accession: P00263
member entity reference: Tumor necrosis factor ligand superfamily member
member entity reference: Tumor necrosis factor ligand superfamily member 10

Tumor necrosis factor ligand superfamily member 6
type: ProteinReference
xref: uniprot P36940 889
xref: PTHR11471:SF33
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r58
controller: AKT

uniprot Q39022 173
type: UnificationXref
id: Q39022
db: uniprot

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot P25963 356
organism: Homo sapiens

Bcl-2-like protein 1
type: ProteinReference
xref: uniprot Q64373 19
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r92 1109
type: Stoichiometry
physical entity: Complex (TRAIL-R/TRAIL)
stoichiometric coefficient: 1.0

uniprot H2QVV9 259
type: UnificationXref
id: H2QVV9
db: uniprot

uniprot P61125 40
type: UnificationXref
id: P61125
db: uniprot

uniprot A0A1D5QZY2 113
type: UnificationXref
id: A0A1D5QZY2
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F1Q3M8 568
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r92 1108
type: Stoichiometry
physical entity: TRAIL
stoichiometric coefficient: 1.0

uniprot F7G769 849
type: UnificationXref
id: F7G769
db: uniprot

PARTICIPANT STOICHIOMETRY r92 1107
type: Stoichiometry
physical entity: TRAIL-R
stoichiometric coefficient: 1.0

uniprot A0A2I3TNR8 94
type: UnificationXref
id: A0A2I3TNR8
db: uniprot

c-IAP1,2
type: ProteinReference
xref: P00264
standard name: Cellular inhibitor of apoptosis protein 1 and 2
comment: ENTITY_REFERENCE_NOTES=Long Name: Cellular inhibitor of apoptosis protein 1 and 2 Synonym: Synonym not specified Accession: P00264
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.c-IAP1,2
member entity reference: Baculoviral IAP repeat-containing 2
member entity reference: Baculoviral IAP repeat-containing protein 2
member entity reference: Uncharacterized protein
member entity reference: Baculoviral IAP repeat-containing 3
member entity reference: Baculoviral IAP repeat containing 3
member entity reference: BIRC2 isoform 11
member entity reference: Baculoviral IAP repeat-containing protein 3
member entity reference: Inhibitor of apoptosis protein

uniprot A0A2I3SPU3 314
type: UnificationXref
id: A0A2I3SPU3
db: uniprot

MADD s29 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MADD
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot H9FVU5 581
organism: Macaca mulatta

JNK
type: Protein
entity reference: JNK
feature: JNK s107 a133 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F7BRQ2 455
type: UnificationXref
id: F7BRQ2
db: uniprot

uniprot H2QS62 236
type: UnificationXref
id: H2QS62
db: uniprot

PARTICIPANT STOICHIOMETRY r51 1073
type: Stoichiometry
physical entity: Caspase 7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 1072
type: Stoichiometry
physical entity: Caspase 7
stoichiometric coefficient: 1.0

Protein kinase C
type: ProteinReference
xref: uniprot F7BYI4 671
xref: PTHR24356:SF158
organism: Macaca mulatta

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot P08169 302
type: UnificationXref
id: P08169
db: uniprot

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: PTHR11584:SF332
xref: uniprot O35099 210
organism: Mus musculus

X-linked inhibitor of apoptosis
type: ProteinReference
xref: uniprot K7D8W8 503
organism: Pan troglodytes

Baculoviral IAP repeat-containing protein 2
type: ProteinReference
xref: uniprot Q62210 101
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ASK1-RIGHT__ASK1-_r67
controller: GCKR

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: uniprot D3ZFJ0 563
xref: PTHR10048:SF34
organism: Rattus norvegicus

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot F6Y841 572
xref: PTHR10048:SF33
organism: Canis lupus familiaris

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 145

Cation-independent mannose-6-phosphate receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot Q07113 304
organism: Mus musculus

uniprot Q0DI31 870
type: UnificationXref
id: Q0DI31
db: uniprot

uniprot Q5U2U8 283
type: UnificationXref
id: Q5U2U8
db: uniprot

TNF
type: ProteinReference
xref: P00259
standard name: Tumor necrosis factor
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.TNF
comment: ENTITY_REFERENCE_NOTES=Long Name: Tumor necrosis factor Synonym: Synonym not specified Accession: P00259
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Lymphotoxin-beta
member entity reference: Lymphotoxin-alpha
member entity reference: Tumor necrosis factor
member entity reference: Lymphotoxin B

MAPK
type: ProteinReference
xref: P00269
standard name: Mitogen activated protein kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen activated protein kinase Synonym: MAP kinase Accession: P00269
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.MAPK
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 5
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase mpk-1
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase 7
member entity reference: Mitogen-activated protein kinase FUS3
member entity reference: Mitogen-activated protein kinase (Fragment)
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase KSS1
member entity reference: Mitogen-activated protein kinase 4
member entity reference: Mitogen-activated protein kinase 2
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase spk1
member entity reference: Mitogen-activated protein kinase 14

uniprot E2RL17 521
type: UnificationXref
id: E2RL17
db: uniprot

Granzyme B(G,H)
type: ProteinReference
xref: uniprot P04187 106
xref: PTHR24271:SF53
organism: Mus musculus

uniprot A0A1D5R3L5 381
type: UnificationXref
id: A0A1D5R3L5
db: uniprot

Pro-apoptotic
type: Pathway

Protein CBG13234
type: ProteinReference
xref: uniprot A8XHD1 721
xref: PTHR19375:SF395
organism: Caenorhabditis briggsae

uniprot Q9WTU6 251
type: UnificationXref
id: Q9WTU6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_7-RIGHT__Caspase_7-_r106
controller: Caspase 10

PARTICIPANT STOICHIOMETRY r87 981
type: Stoichiometry
physical entity: Caspase 10
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6SW23 569
organism: Gallus gallus

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q91974 359
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r87 982
type: Stoichiometry
physical entity: Caspase 10
stoichiometric coefficient: 1.0

uniprot Q8MKI5 514
type: UnificationXref
id: Q8MKI5
db: uniprot

uniprot A0A2J8N1X7 716
type: UnificationXref
id: A0A2J8N1X7
db: uniprot

Apoptosis regulator Bcl-2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot P10417 197
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r12 1007
type: Stoichiometry
physical entity: Caspase 8
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 1008
type: Stoichiometry
physical entity: Caspase 8
stoichiometric coefficient: 1.0

PTHR10044:SF79
type: RelationshipXref
id: PTHR10044:SF79
db: PANTHER Family
relationship type: By Homology

E3 ubiquitin-protein ligase XIAP
type: ProteinReference
xref: uniprot Q9R0I6 507
organism: Rattus norvegicus

JNK
type: Protein
entity reference: JNK
feature: JNK s113 a142 rs1
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Apoptosis regulator Bcl-2
type: ProteinReference
xref: PTHR11256:SF11
xref: uniprot P10415 196
organism: Homo sapiens

PACT
type: ProteinReference
xref: P00280
standard name: Protein activator of interon-induced protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein activator of interon-induced protein kinase Synonym: PKR protein activator,PRKRA,RAX,protein kinase, interferon-inducible double-strand RNA dependent activator Accession: P00280
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.PACT
member entity reference: Interferon-inducible double-stranded RNA-dependent protein kinase activator A
member entity reference: Uncharacterized protein
member entity reference: PRKRA isoform 1

MKK7 s111 a140 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Tumor necrosis factor
type: ProteinReference
xref: uniprot P48094 38
xref: PTHR11471:SF23
organism: Macaca mulatta

uniprot F7FG25 288
type: UnificationXref
id: F7FG25
db: uniprot

Tumor necrosis factor
type: ProteinReference
xref: uniprot P06804 34
xref: PTHR11471:SF23
organism: Mus musculus

FAS
type: Protein
entity reference: FAS

IkappaB s98 a121 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q07113 304
type: UnificationXref
id: Q07113
db: uniprot

uniprot H2Q8H4 524
type: UnificationXref
id: H2Q8H4
db: uniprot

uniprot P01374 32
type: UnificationXref
id: P01374
db: uniprot

Activating transcription factor 7
type: ProteinReference
xref: PTHR19304:SF10
xref: uniprot G3V7X9 460
organism: Rattus norvegicus

uniprot B0S610 730
type: UnificationXref
id: B0S610
db: uniprot

uniprot P09215 684
type: UnificationXref
id: P09215
db: uniprot

cAMP-responsive element modulator
type: ProteinReference
xref: uniprot Q03060 482
organism: Homo sapiens

uniprot Q9M1Z5 191
type: UnificationXref
id: Q9M1Z5
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 185
organism: Danio rerio

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 160

ncbitaxon 237631 139
type: UnificationXref
id: 237631
db: ncbitaxon

uniprot F6QE96 56
type: UnificationXref
id: F6QE96
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 77

uniprot P81269 480
type: UnificationXref
id: P81269
db: uniprot

PTHR11256:SF41
type: RelationshipXref
id: PTHR11256:SF41
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__FADD-_TRADD-RIGHT__Complex__FADD_TRADD_-_r45
controller: Complex (TNFR1/TNF)

uniprot Q05655 700
type: UnificationXref
id: Q05655
db: uniprot

uniprot Q57581 531
type: UnificationXref
id: Q57581
db: uniprot

uniprot F6TEK9 268
type: UnificationXref
id: F6TEK9
db: uniprot

uniprot Q8VIB2 379
type: UnificationXref
id: Q8VIB2
db: uniprot

uniprot F1QK71 740
type: UnificationXref
id: F1QK71
db: uniprot

Unknown adaptor
type: PhysicalEntity
cellular location: intracellular
comment: SPECIES_TYPE=UNKNOWN

uniprot Q383E5 812
type: UnificationXref
id: Q383E5
db: uniprot

uniprot F6S4U9 744
type: UnificationXref
id: F6S4U9
db: uniprot

ncbitaxon 10116 12
type: UnificationXref
id: 10116
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re80 1060
type: Stoichiometry
physical entity: Bcl-2
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase KSS1
type: ProteinReference
xref: PTHR24055:SF338
xref: uniprot P14681 159
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY re80 1061
type: Stoichiometry
physical entity: Bcl-2
stoichiometric coefficient: 1.0

uniprot P00011 854
type: UnificationXref
id: P00011
db: uniprot

PTHR11256:SF51
type: RelationshipXref
id: PTHR11256:SF51
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 221
xref: PTHR24055:SF162
organism: Gallus gallus

Translation initiation factor 2 subunit alpha
type: ProteinReference
xref: uniprot Q8ZTY5 539
organism: Pyrobaculum aerophilum

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8X1S0 226
xref: PTHR24055:SF341
organism: Caenorhabditis briggsae

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 831

uniprot F6R1B6 601
type: UnificationXref
id: F6R1B6
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot P53349 364
organism: Mus musculus

STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_r69
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 1034
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 1033
left: MAPK
interaction type: STATE_TRANSITION
right: MAPK

Granzyme B s23 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Granzyme B
stoichiometric coefficient: 1.0

uniprot F0ZVR4 736
type: UnificationXref
id: F0ZVR4
db: uniprot

uniprot Q497M6 312
type: UnificationXref
id: Q497M6
db: uniprot

Apoptotic protease-activating factor 1
type: ProteinReference
xref: PTHR22845:SF5
xref: uniprot F6U0K7 431
organism: Macaca mulatta

uniprot F1PIC7 739
type: UnificationXref
id: F1PIC7
db: uniprot

PTHR11256:SF42
type: RelationshipXref
id: PTHR11256:SF42
db: PANTHER Family
relationship type: By Homology

MEKK1
type: Protein
entity reference: MEKK1
feature: MEKK1 s112 a139 rs1
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot O45246 767
type: UnificationXref
id: O45246
db: uniprot

PTHR11256:SF48
type: RelationshipXref
id: PTHR11256:SF48
db: PANTHER Family
relationship type: By Homology

uniprot Q3SZT9 873
type: UnificationXref
id: Q3SZT9
db: uniprot

PTHR19304:SF9
type: RelationshipXref
id: PTHR19304:SF9
db: PANTHER Family
relationship type: By Homology

PTHR11256:SF46
type: RelationshipXref
id: PTHR11256:SF46
db: PANTHER Family
relationship type: By Homology

uniprot F7A632 669
type: UnificationXref
id: F7A632
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 182
organism: Danio rerio

PTHR11256:SF47
type: RelationshipXref
id: PTHR11256:SF47
db: PANTHER Family
relationship type: By Homology

Interferon-induced, double-stranded RNA-activated protein kinase
type: ProteinReference
xref: PTHR11042:SF163
xref: uniprot Q03963 369
organism: Mus musculus

Heat shock-related 70 kDa protein 2
type: ProteinReference
xref: uniprot P14659 785
xref: PTHR19375:SF382
organism: Rattus norvegicus

uniprot Q06332 41
type: UnificationXref
id: Q06332
db: uniprot

uniprot K7D430 467
type: UnificationXref
id: K7D430
db: uniprot

Nuclear factor NF-kappa-B p105 subunit
type: ProteinReference
xref: uniprot P19838 401
xref: PTHR24169:SF9
organism: Homo sapiens

Bcl-2-like protein 11
type: ProteinReference
xref: PTHR12044:SF9
xref: uniprot H2R0F7 884
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1P630 227
xref: PTHR24055:SF172
organism: Canis lupus familiaris

Happyhour, isoform A
type: ProteinReference
xref: uniprot A1ZBH7 123
organism: Drosophila melanogaster

Protein kinase C eta type
type: ProteinReference
xref: uniprot P23298 689
xref: PTHR24356:SF192
organism: Mus musculus

XIAP
type: ProteinReference
xref: P00304
standard name: X-linked inhibitor of apoptosis
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.XIAP
comment: ENTITY_REFERENCE_NOTES=Long Name: X-linked inhibitor of apoptosis Synonym: BIRC4,Baculoviral IAP repeat-containing protein 4 Accession: P00304
member entity reference: E3 ubiquitin-protein ligase XIAP
member entity reference: Inhibitor of apoptosis protein 3
member entity reference: X-linked inhibitor of apoptosis

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_7-RIGHT__Caspase_7-_r106
control type: INHIBITION
controller: XIAP

uniprot A9S0A3 726
type: UnificationXref
id: A9S0A3
db: uniprot

Smac/Diablo
type: Protein
entity reference: Smac/Diablo
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 62

uniprot F1MUW4 430
type: UnificationXref
id: F1MUW4
db: uniprot

uniprot Q99M66 320
type: UnificationXref
id: Q99M66
db: uniprot

SEK1 s110 a141 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ELF2alpha-RIGHT__ELF2alpha-_r117
controller: Caspase 3

uniprot Q60855 640
type: UnificationXref
id: Q60855
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9LQQ9 190
xref: PTHR24055:SF438
organism: Arabidopsis thaliana

uniprot Q4KSH7 612
type: UnificationXref
id: Q4KSH7
db: uniprot

uniprot Q9XXC0 252
type: UnificationXref
id: Q9XXC0
db: uniprot

Cyclic AMP-dependent transcription factor ATF-6 alpha
type: ProteinReference
xref: uniprot F6VAN0 451
xref: PTHR46164:SF1
organism: Mus musculus

uniprot A0A3Q1LMD4 122
type: UnificationXref
id: A0A3Q1LMD4
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot H2R0G7 237
organism: Pan troglodytes

BCL2 interacting killer
type: ProteinReference
xref: PTHR15018:SF1
xref: uniprot H2QLU7 26
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot H3E674 762
organism: Pristionchus pacificus

uniprot P97820 606
type: UnificationXref
id: P97820
db: uniprot

ncbitaxon 54126 763
type: UnificationXref
id: 54126
db: ncbitaxon

Granzyme H
type: ProteinReference
xref: uniprot P20718 109
organism: Homo sapiens

PTHR19375:SF223
type: RelationshipXref
id: PTHR19375:SF223
db: PANTHER Family
relationship type: By Homology

uniprot G3X7B5 64
type: UnificationXref
id: G3X7B5
db: uniprot

uniprot Q04759 699
type: UnificationXref
id: Q04759
db: uniprot

ncbitaxon 284812 165
type: UnificationXref
id: 284812
db: ncbitaxon

BCL2-interacting killer
type: ProteinReference
xref: uniprot Q925D2 30
xref: PTHR15018:SF1
organism: Rattus norvegicus

uniprot Q8WQG9 247
type: UnificationXref
id: Q8WQG9
db: uniprot

uniprot P54674 591
type: UnificationXref
id: P54674
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A2I3T7A8 561
organism: Pan troglodytes

Bcl-2-interacting killer
type: ProteinReference
xref: PTHR15018:SF1
xref: uniprot O70337 27
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: uniprot E1BMG4 662
xref: PTHR24356:SF181
organism: Bos taurus

uniprot P68102 530
type: UnificationXref
id: P68102
db: uniprot

Fos s14 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fos
stoichiometric coefficient: 1.0

AGAP002076-PA
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot A7UVK8 718
organism: Anopheles gambiae

Protein kinase C eta type
type: ProteinReference
xref: uniprot P24723 690
xref: PTHR24356:SF192
organism: Homo sapiens

Caspase 7, isoform CRA_c
type: ProteinReference
xref: PTHR10454:SF31
xref: uniprot O88550 428
organism: Rattus norvegicus

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P49186 241
xref: PTHR24055:SF172
organism: Rattus norvegicus

TNF s26 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

ncbitaxon 9913 14
type: UnificationXref
id: 9913
db: ncbitaxon

A1
type: ProteinReference
xref: P00283
standard name: Bcl2-related protein A1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Bcl2-related protein A1 Synonym: Bcl2A1,Bfl1 Accession: P00283
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.A1
member entity reference: Bcl-2-related protein A1
member entity reference: B-cell leukemia/lymphoma 2 related protein A1c
member entity reference: B-cell leukemia/lymphoma 2 related protein A1b
member entity reference: BCL2 related protein A1
member entity reference: Protein A1
member entity reference: Bcl-2-like protein 5
member entity reference: A1-d protein

PKR
type: Protein
entity reference: PKR
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P49187 242
xref: PTHR24055:SF162
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TKL3 229
xref: PTHR24055:SF222
organism: Xenopus tropicalis

Diablo homolog (Drosophila)
type: ProteinReference
xref: PTHR32247:SF3
xref: uniprot Q5RK17 555
organism: Rattus norvegicus

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r87
control type: INHIBITION
controller: Flip

uniprot P00045 857
type: UnificationXref
id: P00045
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__TRAIL_R-_TRAIL-RIGHT__Complex__TRAIL_R_TRAIL_-_r92
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 1108
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 1109
participant stoichiometry: PARTICIPANT STOICHIOMETRY r92 1107
left: TRAIL
left: TRAIL-R
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TRAIL-R/TRAIL)

Complex (TNFR2/TNF/ TRAF2)
type: Complex
component stoichiometry: TNF s247 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRAF2 s51 sa30 STOICHIOMETRY ID COMPLEX
component: TNFR2
component: TNF
component: TRAF2
feature: COMPLEX BINDING FEATURE s209 a339 947
feature: COMPLEX BINDING FEATURE s209 a339 945
feature: ACTIVE 25
feature: COMPLEX BINDING FEATURE s209 a339 943
cellular location: intracellular

Tumor necrosis factor receptor superfamily member 1B
type: ProteinReference
xref: uniprot Q80WY6 335
organism: Rattus norvegicus

Bax
type: Protein
entity reference: Bax
feature: ACTIVE 25
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r69 1034
type: Stoichiometry
physical entity: MAPK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 1033
type: Stoichiometry
physical entity: MAPK
stoichiometric coefficient: 1.0

Translation initiation factor 2, subunit alpha
type: ProteinReference
xref: uniprot Q8TSZ9 537
organism: Methanosarcina acetivorans

uniprot F6S0D1 394
type: UnificationXref
id: F6S0D1
db: uniprot

PTHR10044:SF99
type: RelationshipXref
id: PTHR10044:SF99
db: PANTHER Family
relationship type: By Homology

MAP kinase-activating death domain protein
type: ProteinReference
xref: uniprot Q8WXG6 119
xref: PTHR13008:SF7
organism: Homo sapiens

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot P42574 511
organism: Homo sapiens

Fos proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot E2QYK5 650
organism: Canis lupus familiaris

uniprot F6ZKB3 232
type: UnificationXref
id: F6ZKB3
db: uniprot

Mitogen-activated protein kinase kinase kinase kinase 3
type: ProteinReference
xref: uniprot Q99JP0 609
organism: Mus musculus

Jun dimerization protein 2
type: ProteinReference
xref: uniprot E2QYK4 442
organism: Canis lupus familiaris

TNFRSF1A-associated via death domain
type: ProteinReference
xref: PTHR14913:SF0
xref: uniprot K7CAG9 707
organism: Pan troglodytes

Endonuclease G
type: ProteinReference
xref: uniprot A0A452DIJ1 286
xref: PTHR13966:SF5
organism: Bos taurus

uniprot F7GTP8 850
type: UnificationXref
id: F7GTP8
db: uniprot

uniprot F1PXD3 631
type: UnificationXref
id: F1PXD3
db: uniprot

PTHR32247:SF3
type: RelationshipXref
id: PTHR32247:SF3
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r103 1052
type: Stoichiometry
physical entity: c-IAP1,2
stoichiometric coefficient: 1.0

PKR
type: Protein
entity reference: PKR
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r103 1053
type: Stoichiometry
physical entity: c-IAP1,2
stoichiometric coefficient: 1.0

Eukaryotic translation initiation factor 2 subunit 1
type: ProteinReference
xref: uniprot Q5ZLX2 533
organism: Gallus gallus

Tumor necrosis factor ligand superfamily member 6
type: ProteinReference
xref: uniprot P48023 891
xref: PTHR11471:SF33
organism: Homo sapiens

Eukaryotic Initiation Factor
type: ProteinReference
xref: uniprot Q9BKU3 541
organism: Caenorhabditis elegans

cAMP-responsive element modulator
type: ProteinReference
xref: uniprot P27699 478
organism: Mus musculus

Endonuclease G
type: ProteinReference
xref: uniprot E2RQB6 287
organism: Canis lupus familiaris

uniprot P05627 499
type: UnificationXref
id: P05627
db: uniprot

PARTICIPANT STOICHIOMETRY r123 994
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r123 995
type: Stoichiometry
physical entity: TNFR1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r123 996
type: Stoichiometry
physical entity: Complex (TNFR1/TNF)
stoichiometric coefficient: 1.0

Cyclic AMP-dependent transcription factor ATF-1
type: ProteinReference
xref: uniprot F7HB38 459
xref: PTHR45879:SF2
organism: Macaca mulatta

uniprot Q16548 311
type: UnificationXref
id: Q16548
db: uniprot

uniprot E2QYK4 442
type: UnificationXref
id: E2QYK4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SEK1-RIGHT__SEK1-_r73
controller: ASK1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK-RIGHT__MAPK-_r69
controller: MKK3

Bcl-2-like protein 2
type: ProteinReference
xref: PTHR11256:SF13
xref: uniprot Q1RMX3 646
organism: Bos taurus

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Caspase_8-RIGHT__Caspase_8-_r53
control type: INHIBITION
controller: Flip

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

uniprot Q9VUU5 558
type: UnificationXref
id: Q9VUU5
db: uniprot

uniprot F1NG47 667
type: UnificationXref
id: F1NG47
db: uniprot

uniprot L7N050 766
type: UnificationXref
id: L7N050
db: uniprot

uniprot Q23240 872
type: UnificationXref
id: Q23240
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 68
organism: Homo sapiens

uniprot F6W7C8 571
type: UnificationXref
id: F6W7C8
db: uniprot

uniprot F7EFD7 523
type: UnificationXref
id: F7EFD7
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 67
organism: Mus musculus

PTHR24356:SF240
type: RelationshipXref
id: PTHR24356:SF240
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__XIAP-RIGHT__XIAP-_r118
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r118 1003
participant stoichiometry: PARTICIPANT STOICHIOMETRY r118 1004
left: XIAP
interaction type: STATE_TRANSITION
right: XIAP

Bos taurus
type: BioSource
xref: ncbitaxon 9913 14

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9WUA6 79
xref: PTHR24356:SF190
organism: Mus musculus

Translation initiation factor 2 subunit alpha
type: ProteinReference
xref: uniprot Q57581 531
organism: Methanocaldococcus jannaschii

uniprot P09435 772
type: UnificationXref
id: P09435
db: uniprot

PARTICIPANT STOICHIOMETRY r105 1043
type: Stoichiometry
physical entity: Caspase 3
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__FADD-_DAXX-_Complex__FAS_FAS_ligand_-RIGHT__Complex__FAS_DAXX__FADD_FAS_ligand_-_r131
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r131 1112
participant stoichiometry: PARTICIPANT STOICHIOMETRY r131 1111
participant stoichiometry: PARTICIPANT STOICHIOMETRY r131 1113
participant stoichiometry: PARTICIPANT STOICHIOMETRY r131 1110
left: FADD
left: DAXX
left: Complex (FAS/FAS ligand)
interaction type: STATE_TRANSITION
right: Complex (FAS/DAXX/ FADD/FAS ligand)

PARTICIPANT STOICHIOMETRY r105 1044
type: Stoichiometry
physical entity: Caspase 3
stoichiometric coefficient: 1.0

uniprot Q27975 811
type: UnificationXref
id: Q27975
db: uniprot

PTHR46205:SF2
type: RelationshipXref
id: PTHR46205:SF2
db: PANTHER Family
relationship type: By Homology

Caspase 7
type: ProteinReference
xref: uniprot F1MD58 427
xref: PTHR10454:SF31
organism: Bos taurus

Activating transcription factor 4 (Tax-responsive enhancer element B67)
type: ProteinReference
xref: PTHR13044:SF2
xref: uniprot H2QLQ7 465
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r54
controller: Complex (TRADD/RAIDD/ TRAF2/RIP)

uniprot P15336 470
type: UnificationXref
id: P15336
db: uniprot

PTHR48013:SF21
type: RelationshipXref
id: PTHR48013:SF21
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__MKK7-RIGHT__MKK7-_r71
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1030
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 1029
left: MKK7
interaction type: STATE_TRANSITION
right: MKK7

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31749 66
xref: PTHR24356:SF171
organism: Homo sapiens

uniprot P10591 779
type: UnificationXref
id: P10591
db: uniprot

Tumor necrosis factor
type: ProteinReference
xref: uniprot A0A452DJ61 31
xref: PTHR11471:SF23
organism: Bos taurus

STATE_TRANSITION_LEFT__Bcl_2-RIGHT__Bcl_2-_re80
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re80 1060
participant stoichiometry: PARTICIPANT STOICHIOMETRY re80 1061
left: Bcl-2
interaction type: STATE_TRANSITION
right: Bcl-2

uniprot A0A3Q1MNG1 629
type: UnificationXref
id: A0A3Q1MNG1
db: uniprot

Cytochrome c iso-1
type: ProteinReference
xref: uniprot P00044 856
organism: Saccharomyces cerevisiae

Cytochrome c iso-2
type: ProteinReference
xref: uniprot P00045 857
organism: Saccharomyces cerevisiae

TRADD
type: Protein
entity reference: TRADD
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa2 924
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Cytochrome c
type: ProteinReference
xref: uniprot P00046 858
organism: Schizosaccharomyces pombe

Cytochrome c
type: ProteinReference
xref: uniprot P00048 859
organism: Neurospora crassa

uniprot P17066 788
type: UnificationXref
id: P17066
db: uniprot

Heat shock 70 kDa protein 1A
type: ProteinReference
xref: PTHR19375:SF223
xref: uniprot Q27975 811
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r59 1062
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

MKK3
type: ProteinReference
xref: P00314
standard name: Mitogen activated protein kinase kinase 3
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen activated protein kinase kinase 3 Synonym: MAP kinase kinase 3,MAPKK3 Accession: P00314
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.MKK3
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase 3
member entity reference: Dual specificity mitogen-activated protein kinase kinase 3
member entity reference: Map2k3 protein

Uncharacterized protein
type: ProteinReference
xref: uniprot G5ECU5 758
xref: PTHR19375:SF395
organism: Caenorhabditis elegans

Heat shock protein
type: ProteinReference
xref: PTHR19375:SF426
xref: uniprot F0ZVR4 736
organism: Dictyostelium purpureum

HETERODIMER_ASSOCIATION_LEFT__TNF-_TNFR2-RIGHT__Complex__TNFR2_TNF_-_r128
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r128 976
participant stoichiometry: PARTICIPANT STOICHIOMETRY r128 977
participant stoichiometry: PARTICIPANT STOICHIOMETRY r128 978
left: TNF
left: TNFR2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TNFR2/TNF)

uniprot O93602 469
type: UnificationXref
id: O93602
db: uniprot

PARTICIPANT STOICHIOMETRY r22 980
type: Stoichiometry
physical entity: NIK
stoichiometric coefficient: 1.0

Probable cytochrome c 2.2
type: ProteinReference
xref: uniprot Q23240 872
organism: Caenorhabditis elegans

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot A0A2I3SR38 659
organism: Pan troglodytes

uniprot Q9W610 494
type: UnificationXref
id: Q9W610
db: uniprot

PTHR15071:SF17
type: RelationshipXref
id: PTHR15071:SF17
db: PANTHER Family
relationship type: By Homology

TNFR1 s25 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TNFR1
stoichiometric coefficient: 3.0

STATE_TRANSITION_LEFT__ATF-RIGHT__ATF-_r74
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 1016
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 1015
left: ATF
interaction type: STATE_TRANSITION
right: ATF

uniprot Q6Z7B0 825
type: UnificationXref
id: Q6Z7B0
db: uniprot

Cytochrome c
type: ProteinReference
xref: uniprot P38091 862
organism: Emericella nidulans

RELB proto-oncogene, NF-kB subunit
type: ProteinReference
xref: uniprot A0A2I3TGI5 385
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r36 1093
type: Stoichiometry
physical entity: AIF
stoichiometric coefficient: 1.0

FADD s2 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FADD
stoichiometric coefficient: 1.0

JNK s107 a133 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r36 1092
type: Stoichiometry
physical entity: AIF
stoichiometric coefficient: 1.0

uniprot F6ZR51 454
type: UnificationXref
id: F6ZR51
db: uniprot

RAC serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q8INB9 76
organism: Drosophila melanogaster

Heat shock protein family A (Hsp70) member 6
type: ProteinReference
xref: uniprot F1MWU9 738
xref: PTHR19375:SF168
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r59 1063
type: Stoichiometry
physical entity: AKT
stoichiometric coefficient: 1.0

uniprot K7CDC2 65
type: UnificationXref
id: K7CDC2
db: uniprot

uniprot F7GUS9 458
type: UnificationXref
id: F7GUS9
db: uniprot

uniprot Q9I9N5 710
type: UnificationXref
id: Q9I9N5
db: uniprot

uniprot A0A1D5QK27 413
type: UnificationXref
id: A0A1D5QK27
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 16

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_7-RIGHT__Caspase_7-_r51
controller: Caspase 10

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ASK1-RIGHT__ASK1-_r83
controller: Complex (FAS/DAXX/ FADD/FAS ligand)

TNF s28 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

uniprot Q7SX83 489
type: UnificationXref
id: Q7SX83
db: uniprot

uniprot P27420 796
type: UnificationXref
id: P27420
db: uniprot

uniprot H2Q0H3 462
type: UnificationXref
id: H2Q0H3
db: uniprot

Apoptosis-inducing factor 1, mitochondrial
type: ProteinReference
xref: uniprot Q9Z0X1 330
xref: PTHR43557:SF4
organism: Mus musculus

PTHR11256:SF13
type: RelationshipXref
id: PTHR11256:SF13
db: PANTHER Family
relationship type: By Homology

uniprot P0DMW0 777
type: UnificationXref
id: P0DMW0
db: uniprot

PTHR11256:SF12
type: RelationshipXref
id: PTHR11256:SF12
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r55 1067
type: Stoichiometry
physical entity: GCKR
stoichiometric coefficient: 1.0

PTHR11256:SF11
type: RelationshipXref
id: PTHR11256:SF11
db: PANTHER Family
relationship type: By Homology

Cytochrome c 2
type: ProteinReference
xref: uniprot Q3SZT9 873
organism: Bos taurus

PTHR11256:SF10
type: RelationshipXref
id: PTHR11256:SF10
db: PANTHER Family
relationship type: By Homology

ELF2alpha
type: ProteinReference
xref: P00307
standard name: Translation initiation factor 2-alpha
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.ELF2_alpha_
comment: ENTITY_REFERENCE_NOTES=Long Name: Translation initiation factor 2-alpha Synonym: eIF2 alpha Accession: P00307
member entity reference: Uncharacterized protein
member entity reference: Eukaryotic translation initiation factor 2 subunit alpha
member entity reference: Eukaryotic Initiation Factor
member entity reference: Eukaryotic translation initiation factor 2 subunit 1
member entity reference: Translation initiation factor 2 subunit alpha
member entity reference: Eukaryotic translation initiation factor 2, subunit 1 alpha
member entity reference: Translation initiation factor 2, subunit alpha
member entity reference: EIF2S1 isoform 1
member entity reference: Eif2s1l protein
member entity reference: AGAP011190-PA (Fragment)
member entity reference: Eukaryotic translation initiation factor 2 subunit alpha homolog

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q5PU49 702
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r104 1048
type: Stoichiometry
physical entity: Caspase 9
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ELF2alpha-RIGHT__ELF2alpha-_r117
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r117 1006
participant stoichiometry: PARTICIPANT STOICHIOMETRY r117 1005
left: ELF2alpha
interaction type: STATE_TRANSITION
right: ELF2alpha

PARTICIPANT STOICHIOMETRY r55 1066
type: Stoichiometry
physical entity: GCKR
stoichiometric coefficient: 1.0

uniprot A9SNF1 727
type: UnificationXref
id: A9SNF1
db: uniprot

uniprot Q6P023 182
type: UnificationXref
id: Q6P023
db: uniprot

uniprot P41374 527
type: UnificationXref
id: P41374
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Pro-apoptotic
controller: Caspase 9

uniprot Q63746 357
type: UnificationXref
id: Q63746
db: uniprot

PARTICIPANT STOICHIOMETRY r104 1047
type: Stoichiometry
physical entity: Caspase 9
stoichiometric coefficient: 1.0

uniprot O54918 887
type: UnificationXref
id: O54918
db: uniprot

uniprot P53779 243
type: UnificationXref
id: P53779
db: uniprot

uniprot O55179 307
type: UnificationXref
id: O55179
db: uniprot

TRAIL
type: Protein
entity reference: TRAIL
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa14 928
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

c-Jun
type: ProteinReference
xref: P00303
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.c-Jun
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit
member entity reference: Transcription factor AP-1
member entity reference: Jun proto-oncogene

EIF2S1 isoform 1
type: ProteinReference
xref: uniprot H2Q8H4 524
organism: Pan troglodytes

a127_degraded
type: PhysicalEntity
cellular location: intracellular
comment: SPECIES_TYPE=DEGRADED

uniprot E2RJX4 51
type: UnificationXref
id: E2RJX4
db: uniprot

Granzyme B
type: Protein
entity reference: Granzyme B
comment: SPECIES_TYPE=PROTEIN

Cytochrome c, testis-specific
type: ProteinReference
xref: uniprot P00015 855
organism: Mus musculus

Heat shock 70 kDa protein 1A
type: ProteinReference
xref: PTHR19375:SF223
xref: uniprot P0DMW0 777
organism: Rattus norvegicus

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot E2RCV1 566
organism: Canis lupus familiaris

Heat shock 70 kDa protein 1B
type: ProteinReference
xref: PTHR19375:SF223
xref: uniprot P0DMW1 778
organism: Rattus norvegicus

Cytochrome c
type: ProteinReference
xref: PTHR11961:SF15
xref: uniprot P00011 854
organism: Canis lupus familiaris

PTHR11584:SF332
type: RelationshipXref
id: PTHR11584:SF332
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r129 973
type: Stoichiometry
physical entity: TRAF2
stoichiometric coefficient: 1.0

Complex (Fos/c-Jun)
type: Complex
component stoichiometry: Fos s14 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: c Jun s15 sa10 STOICHIOMETRY ID COMPLEX
component: c-Jun
component: Fos
feature: COMPLEX BINDING FEATURE s123 a149 913
feature: ACTIVE 25
feature: COMPLEX BINDING FEATURE s123 a149 915
cellular location: nucleus

Heat shock 70 kDa protein 1A
type: ProteinReference
xref: uniprot P0DMV8 775
xref: PTHR19375:SF223
organism: Homo sapiens

Heat shock 70 kDa protein 1B
type: ProteinReference
xref: PTHR19375:SF223
xref: uniprot P0DMV9 776
organism: Homo sapiens

Bax inhibitor 1
type: ProteinReference
xref: uniprot Q9LD45 275
organism: Arabidopsis thaliana

IkappaB s95 a118 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Caspase 3
type: Protein
entity reference: Caspase 3
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot E2QTJ4 115
type: UnificationXref
id: E2QTJ4
db: uniprot

PARTICIPANT STOICHIOMETRY r129 974
type: Stoichiometry
physical entity: Complex (TNFR2/TNF)
stoichiometric coefficient: 1.0

Diva
type: Protein
entity reference: Diva
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r129 975
type: Stoichiometry
physical entity: Complex (TNFR2/TNF/ TRAF2)
stoichiometric coefficient: 1.0

uniprot Q9UMX3 89
type: UnificationXref
id: Q9UMX3
db: uniprot

Heat shock 70 kDa protein
type: ProteinReference
xref: uniprot Q01233 808
xref: PTHR19375:SF426
organism: Neurospora crassa

uniprot P46734 636
type: UnificationXref
id: P46734
db: uniprot

cAMP-responsive element-binding protein 1
type: ProteinReference
xref: uniprot F6QA46 450
xref: PTHR45879:SF1
organism: Xenopus tropicalis

Heat shock cognate 71 kDa protein
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot Q90473 833
organism: Danio rerio

uniprot Q63844 181
type: UnificationXref
id: Q63844
db: uniprot

Cytochrome c
type: ProteinReference
xref: uniprot P00002 853
xref: PTHR11961:SF29
organism: Macaca mulatta

Insulin-like growth factor 2 receptor
type: ProteinReference
xref: PTHR15071:SF17
xref: uniprot G3V824 300
organism: Rattus norvegicus

uniprot F6S9W7 91
type: UnificationXref
id: F6S9W7
db: uniprot

uniprot Q9LD45 275
type: UnificationXref
id: Q9LD45
db: uniprot

Jun proto-oncogene
type: ProteinReference
xref: uniprot F6RYL1 496
xref: PTHR11462:SF8
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r106 1040
type: Stoichiometry
physical entity: Caspase 7
stoichiometric coefficient: 1.0

IkappaB s98 a121 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.9622796218629746
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot P05412 498
type: UnificationXref
id: P05412
db: uniprot

PARTICIPANT STOICHIOMETRY r106 1039
type: Stoichiometry
physical entity: Caspase 7
stoichiometric coefficient: 1.0

IkappaB s95 a118 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=1.9622796218629746
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Caspase 8
type: Protein
entity reference: Caspase 8
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F6ZXI7 751
type: UnificationXref
id: F6ZXI7
db: uniprot

uniprot A0A2I3RFE8 374
type: UnificationXref
id: A0A2I3RFE8
db: uniprot

uniprot F7GWD0 269
type: UnificationXref
id: F7GWD0
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6R8N3 59
xref: PTHR24356:SF190
organism: Macaca mulatta

Mitogen-activated protein kinase kinase kinase 14
type: ProteinReference
xref: uniprot F7B742 879
xref: PTHR48016:SF9
organism: Macaca mulatta

uniprot K7CFQ9 209
type: UnificationXref
id: K7CFQ9
db: uniprot

PARTICIPANT STOICHIOMETRY r58 1064
type: Stoichiometry
physical entity: IKK
stoichiometric coefficient: 1.0

uniprot A5A6H0 648
type: UnificationXref
id: A5A6H0
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6VXG1 570
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r58 1065
type: Stoichiometry
physical entity: IKK
stoichiometric coefficient: 1.0

Protein kinase C eta type
type: ProteinReference
xref: uniprot H2Q8F2 674
xref: PTHR24356:SF192
organism: Pan troglodytes

uniprot P99998 868
type: UnificationXref
id: P99998
db: uniprot

Death domain-associated protein 6
type: ProteinReference
xref: uniprot Q8VIB2 379
xref: PTHR12766:SF7
organism: Rattus norvegicus

Heat shock protein family A (Hsp70) member 2
type: ProteinReference
xref: uniprot F6ZXI7 751
xref: PTHR19375:SF382
organism: Ornithorhynchus anatinus

endoG
type: Protein
entity reference: endoG
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

TRADD
type: ProteinReference
xref: P00319
standard name: TNFR1 associated death domain
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.TRADD
comment: ENTITY_REFERENCE_NOTES=Long Name: TNFR1 associated death domain Synonym: Synonym not specified Accession: P00319
member entity reference: Tumor necrosis factor receptor type 1-associated DEATH domain protein
member entity reference: TNFRSF1A-associated via death domain
member entity reference: Uncharacterized protein

uniprot F6XD14 452
type: UnificationXref
id: F6XD14
db: uniprot

uniprot P19438 340
type: UnificationXref
id: P19438
db: uniprot

Complex (FAS/FAS ligand)
type: Complex
component stoichiometry: FAS ligand s61 sa32 STOICHIOMETRY ID COMPLEX
component: FAS
component: FAS ligand
feature: COMPLEX BINDING FEATURE s211 a342 949
feature: ACTIVE 25
feature: COMPLEX BINDING FEATURE s211 a342 951
cellular location: intracellular

ncbitaxon 35128 732
type: UnificationXref
id: 35128
db: ncbitaxon

Caspase 8
type: Protein
entity reference: Caspase 8
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot P18848 476
type: UnificationXref
id: P18848
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 171

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NIK-RIGHT__NIK-_r22
controller: Complex (TNFR2/TNF/ TRAF2)

PARTICIPANT STOICHIOMETRY r101 1055
type: Stoichiometry
physical entity: Apaf-1
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q12851 134
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r101 1054
type: Stoichiometry
physical entity: Apaf-1
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__Complex__Bax_Bak_-RIGHT__Bax-_Bak-_r96
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 1101
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 1100
participant stoichiometry: PARTICIPANT STOICHIOMETRY r96 1099
left: Complex (Bax/Bak)
interaction type: DISSOCIATION
right: Bak
right: Bax

uniprot Q4G097 486
type: UnificationXref
id: Q4G097
db: uniprot

SEK1 s109 a135 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot P25446 348
type: UnificationXref
id: P25446
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK1-RIGHT__MEKK1-_r70
controller: GCKR

uniprot O02718 195
type: UnificationXref
id: O02718
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P28867 691
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r94 1106
type: Stoichiometry
physical entity: Unknown adaptor
stoichiometric coefficient: 1.0

uniprot P16627 787
type: UnificationXref
id: P16627
db: uniprot

PARTICIPANT STOICHIOMETRY r94 1105
type: Stoichiometry
physical entity: Complex (TRAIL-R/TRAIL)
stoichiometric coefficient: 1.0

uniprot P62898 865
type: UnificationXref
id: P62898
db: uniprot

PARTICIPANT STOICHIOMETRY r28 970
type: Stoichiometry
physical entity: Bid
stoichiometric coefficient: 1.0

uniprot G5ECU5 758
type: UnificationXref
id: G5ECU5
db: uniprot

Interferon-inducible double-stranded RNA-dependent protein kinase activator A
type: ProteinReference
xref: PTHR46205:SF2
xref: uniprot Q9WTX2 298
organism: Mus musculus

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A2I3RZ31 222
xref: PTHR24055:SF162
organism: Pan troglodytes

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7A632 669
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__P53-RIGHT__P53-_r119
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r119 1002
participant stoichiometry: PARTICIPANT STOICHIOMETRY r119 1001
left: P53
interaction type: STATE_TRANSITION
right: P53

uniprot A0A1D5QUZ8 141
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

uniprot P09216 685
type: UnificationXref
id: P09216
db: uniprot

STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r49
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1080
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 1081
left: Caspase 10
interaction type: STATE_TRANSITION
right: Caspase 10

PTHR11447:SF6
type: RelationshipXref
id: PTHR11447:SF6
db: PANTHER Family
relationship type: By Homology

BCL2-associated X, apoptosis regulator a
type: ProteinReference
xref: uniprot I3ITC2 201
organism: Danio rerio

PTHR23351:SF23
type: RelationshipXref
id: PTHR23351:SF23
db: PANTHER Family
relationship type: By Homology

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P01101 655
xref: PTHR23351:SF4
organism: Mus musculus

uniprot Q9C7X7 838
type: UnificationXref
id: Q9C7X7
db: uniprot

STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r54
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 1069
participant stoichiometry: PARTICIPANT STOICHIOMETRY r54 1068
left: Caspase 10
interaction type: STATE_TRANSITION
right: Caspase 10

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P01100 654
xref: PTHR23351:SF4
organism: Homo sapiens

PTHR10131:SF21
type: RelationshipXref
id: PTHR10131:SF21
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR44329:SF6
xref: uniprot F6THC2 637
organism: Macaca mulatta

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q91Y86 248
organism: Mus musculus

uniprot P10415 196
type: UnificationXref
id: P10415
db: uniprot

Death domain-containing protein CRADD
type: ProteinReference
xref: PTHR15034:SF5
xref: uniprot O88843 372
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r28 969
type: Stoichiometry
physical entity: Bid
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r50 1075
type: Stoichiometry
physical entity: Caspase 3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r50 1074
type: Stoichiometry
physical entity: Caspase 3
stoichiometric coefficient: 1.0

FAS-associated death domain protein
type: ProteinReference
xref: PTHR15077:SF9
xref: uniprot H2Q4B6 893
organism: Pan troglodytes

Bik
type: Protein
entity reference: Bik
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa18 956
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PTHR12329:SF10
type: RelationshipXref
id: PTHR12329:SF10
db: PANTHER Family
relationship type: By Homology

PTHR12329:SF16
type: RelationshipXref
id: PTHR12329:SF16
db: PANTHER Family
relationship type: By Homology

PTHR14913:SF0
type: RelationshipXref
id: PTHR14913:SF0
db: PANTHER Family
relationship type: By Homology

GCKR
type: ProteinReference
xref: P00311
standard name: Germinal center kinase related
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Germinal center kinase related Synonym: MAP4K3,MAP4K4,Mitogen-activated protein kinase kinase kinase kinase 3,Mitogen-activated protein kinase kinase kinase kinase 4 Accession: P00311
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.GCKR
member entity reference: Mitogen-activated protein kinase kinase kinase kinase
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 3
member entity reference: Happyhour, isoform A
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 1
member entity reference: Mitogen-activated protein kinase kinase kinase kinase 5

uniprot F7GVU6 396
type: UnificationXref
id: F7GVU6
db: uniprot

STATE_TRANSITION_LEFT__Caspase_3-RIGHT__Caspase_3-_r105
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 1044
participant stoichiometry: PARTICIPANT STOICHIOMETRY r105 1043
left: Caspase 3
interaction type: STATE_TRANSITION
right: Caspase 3

uniprot P29843 797
type: UnificationXref
id: P29843
db: uniprot

uniprot Q8R2E7 896
type: UnificationXref
id: Q8R2E7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_r19
controller: Complex (TRADD/RAIDD/ TRAF2/RIP)

BCL2-like 1
type: ProteinReference
xref: uniprot Q05KJ0 13
xref: PTHR11256:SF12
organism: Bos taurus

P00259
type: UnificationXref
id: P00259
db: PANTHER Pathway Component

Lymphotoxin-beta
type: ProteinReference
xref: uniprot Q06643 43
xref: PTHR11471:SF29
organism: Homo sapiens

P00258
type: UnificationXref
id: P00258
db: PANTHER Pathway Component

P00257
type: UnificationXref
id: P00257
db: PANTHER Pathway Component

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot H2Q8A0 132
organism: Pan troglodytes

P00266
type: UnificationXref
id: P00266
db: PANTHER Pathway Component

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot P29844 798
organism: Drosophila melanogaster

uniprot Q62210 101
type: UnificationXref
id: Q62210
db: uniprot

P00267
type: UnificationXref
id: P00267
db: PANTHER Pathway Component

Heat shock 70 kDa protein cognate 1
type: ProteinReference
xref: PTHR19375:SF457
xref: uniprot P29843 797
organism: Drosophila melanogaster

P00264
type: UnificationXref
id: P00264
db: PANTHER Pathway Component

uniprot P42336 585
type: UnificationXref
id: P42336
db: uniprot

P00265
type: UnificationXref
id: P00265
db: PANTHER Pathway Component

P00263
type: UnificationXref
id: P00263
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H9J1 362
xref: PTHR24361:SF414
organism: Macaca mulatta

P00260
type: UnificationXref
id: P00260
db: PANTHER Pathway Component

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot A0A2I3SHM4 121
organism: Pan troglodytes

uniprot H2RA86 156
type: UnificationXref
id: H2RA86
db: uniprot

uniprot F1Q4F8 55
type: UnificationXref
id: F1Q4F8
db: uniprot

P00261
type: UnificationXref
id: P00261
db: PANTHER Pathway Component

uniprot Q5TM22 45
type: UnificationXref
id: Q5TM22
db: uniprot

PARTICIPANT STOICHIOMETRY r20 990
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 991
type: Stoichiometry
physical entity: PKCs
stoichiometric coefficient: 1.0

Bid
type: Protein
feature: ACTIVE 25
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

Apoptosis-inducing factor 1, mitochondrial
type: ProteinReference
xref: uniprot F7C7H6 326
xref: PTHR43557:SF4
organism: Macaca mulatta

Caspase 8, apoptosis-related cysteine peptidase
type: ProteinReference
xref: uniprot F1QLH0 419
organism: Danio rerio

TRAF2
type: Protein
entity reference: TRAF2
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa5 966
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r112 1021
type: Stoichiometry
physical entity: Complex (IGFR2/Granzyme B)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r112 1022
type: Stoichiometry
physical entity: Granzyme B
stoichiometric coefficient: 1.0

uniprot F1PMN2 228
type: UnificationXref
id: F1PMN2
db: uniprot

uniprot P02340 213
type: UnificationXref
id: P02340
db: uniprot

PARTICIPANT STOICHIOMETRY r112 1023
type: Stoichiometry
physical entity: IGFR2
stoichiometric coefficient: 1.0

Induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1
type: ProteinReference
xref: PTHR11256:SF46
xref: uniprot F7HUE9 547
organism: Macaca mulatta

Granzyme B
type: Protein
entity reference: Granzyme B
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

FAS s62 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAS
stoichiometric coefficient: 3.0

Cyclic AMP-dependent transcription factor ATF-6 beta
type: ProteinReference
xref: uniprot O35451 468
xref: PTHR46164:SF2
organism: Mus musculus

Heat shock 70 kDa protein 5
type: ProteinReference
xref: uniprot Q9S9N1 841
xref: PTHR19375:SF436
organism: Arabidopsis thaliana

Probable mediator of RNA polymerase II transcription subunit 37c
type: ProteinReference
xref: PTHR19375:SF413
xref: uniprot Q9LHA8 839
organism: Arabidopsis thaliana

Bak
type: Protein
entity reference: Bak
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa16 900
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q23290 135
type: UnificationXref
id: Q23290
db: uniprot

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

Bcl-2-like protein 5
type: ProteinReference
xref: PTHR11256:SF10
xref: uniprot F7E8W5 306
organism: Macaca mulatta

uniprot O09110 635
type: UnificationXref
id: O09110
db: uniprot

Mitogen-activated protein kinase kinase kinase kinase 3
type: ProteinReference
xref: uniprot Q8IVH8 607
organism: Homo sapiens

P00279
type: UnificationXref
id: P00279
db: PANTHER Pathway Component

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 165

TNF
type: Protein
entity reference: TNF
feature: COMPLEX PARTICIPANT BINDING FEATURE s249 sa29 904
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Mcl1
type: Protein
entity reference: Mcl1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

NF kappa B inhibitor alpha (Fragment)
type: ProteinReference
xref: uniprot Q8WNW7 358
xref: PTHR46680:SF1
organism: Bos taurus

ncbitaxon 5759 734
type: UnificationXref
id: 5759
db: ncbitaxon

uniprot Q8R0S1 490
type: UnificationXref
id: Q8R0S1
db: uniprot

uniprot F7EH19 152
type: UnificationXref
id: F7EH19
db: uniprot

STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r87
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 982
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 981
left: Caspase 10
interaction type: STATE_TRANSITION
right: Caspase 10

Apoptosis regulator BAX
type: ProteinReference
xref: uniprot Q63690 205
xref: PTHR11256:SF42
organism: Rattus norvegicus

uniprot B1H230 630
type: UnificationXref
id: B1H230
db: uniprot

PARTICIPANT STOICHIOMETRY r22 979
type: Stoichiometry
physical entity: NIK
stoichiometric coefficient: 1.0

PTHR45879:SF1
type: RelationshipXref
id: PTHR45879:SF1
db: PANTHER Family
relationship type: By Homology

P00280
type: UnificationXref
id: P00280
db: PANTHER Pathway Component

uniprot Q6Z437 183
type: UnificationXref
id: Q6Z437
db: uniprot

PTHR45879:SF2
type: RelationshipXref
id: PTHR45879:SF2
db: PANTHER Family
relationship type: By Homology

uniprot O97125 770
type: UnificationXref
id: O97125
db: uniprot

P00285
type: UnificationXref
id: P00285
db: PANTHER Pathway Component

P00284
type: UnificationXref
id: P00284
db: PANTHER Pathway Component

Apoptotic protease-activating factor 1
type: ProteinReference
xref: uniprot O88879 434
xref: PTHR22845:SF5
organism: Mus musculus

P00283
type: UnificationXref
id: P00283
db: PANTHER Pathway Component

Nuclear factor kappa B subunit 2
type: ProteinReference
xref: PTHR24169:SF21
xref: uniprot E2RLL2 388
organism: Canis lupus familiaris

Proto-oncogene c-Rel
type: ProteinReference
xref: PTHR24169:SF4
xref: uniprot P15307 399
organism: Mus musculus

P00282
type: UnificationXref
id: P00282
db: PANTHER Pathway Component

P00289
type: UnificationXref
id: P00289
db: PANTHER Pathway Component

P00288
type: UnificationXref
id: P00288
db: PANTHER Pathway Component

P00287
type: UnificationXref
id: P00287
db: PANTHER Pathway Component

P00286
type: UnificationXref
id: P00286
db: PANTHER Pathway Component

uniprot O77628 653
type: UnificationXref
id: O77628
db: uniprot

P00268
type: UnificationXref
id: P00268
db: PANTHER Pathway Component

P00269
type: UnificationXref
id: P00269
db: PANTHER Pathway Component

uniprot Q9QY78 627
type: UnificationXref
id: Q9QY78
db: uniprot

SEK1
type: Protein
entity reference: SEK1
feature: SEK1 s110 a141 rs1
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Bcl-2-related ovarian killer protein
type: ProteinReference
xref: PTHR11256:SF48
xref: uniprot Q9UMX3 89
organism: Homo sapiens

uniprot E1BCY2 441
type: UnificationXref
id: E1BCY2
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Bcl_2-RIGHT__Bcl_2-_re80
control type: INHIBITION
controller: Blk

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BCY2 441
organism: Bos taurus

Complex (TRAIL-R/TRAIL)
type: Complex
component stoichiometry: TRAIL s17 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: TRAIL R s16 sa13 STOICHIOMETRY ID COMPLEX
component: TRAIL-R
component: TRAIL
feature: COMPLEX BINDING FEATURE s171 a270 925
feature: COMPLEX BINDING FEATURE s171 a270 927
feature: ACTIVE 25
cellular location: intracellular

Tumor necrosis factor receptor superfamily member 1B
type: ProteinReference
xref: uniprot P20333 333
xref: PTHR47386:SF1
organism: Homo sapiens

NFkappaB
type: Protein
entity reference: NFkappaB
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa8 932
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

P00270
type: UnificationXref
id: P00270
db: PANTHER Pathway Component

uniprot P49186 241
type: UnificationXref
id: P49186
db: uniprot

Putative heat-shock protein hsp70
type: ProteinReference
xref: PTHR19375:SF395
xref: uniprot Q4Q7Y4 815
organism: Leishmania major

P00272
type: UnificationXref
id: P00272
db: PANTHER Pathway Component

P00271
type: UnificationXref
id: P00271
db: PANTHER Pathway Component

uniprot Q8S0R8 876
type: UnificationXref
id: Q8S0R8
db: uniprot

P00274
type: UnificationXref
id: P00274
db: PANTHER Pathway Component

ncbitaxon 3702 158
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot O14763 262
type: UnificationXref
id: O14763
db: uniprot

P00273
type: UnificationXref
id: P00273
db: PANTHER Pathway Component

P00276
type: UnificationXref
id: P00276
db: PANTHER Pathway Component

P00275
type: UnificationXref
id: P00275
db: PANTHER Pathway Component

P00278
type: UnificationXref
id: P00278
db: PANTHER Pathway Component

P00277
type: UnificationXref
id: P00277
db: PANTHER Pathway Component

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot Q9WTU6 251
organism: Mus musculus

uniprot P10361 215
type: UnificationXref
id: P10361
db: uniprot

Bcl-2-related ovarian killer protein
type: ProteinReference
xref: PTHR11256:SF48
xref: uniprot O35425 86
organism: Mus musculus

uniprot E9PU78 877
type: UnificationXref
id: E9PU78
db: uniprot

PTHR10454:SF26
type: RelationshipXref
id: PTHR10454:SF26
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AKT-RIGHT__AKT-_r59
controller: PI3K

uniprot Q8TSZ9 537
type: UnificationXref
id: Q8TSZ9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HFY2 509
xref: PTHR10454:SF198
organism: Macaca mulatta

PTHR10454:SF31
type: RelationshipXref
id: PTHR10454:SF31
db: PANTHER Family
relationship type: By Homology

Cytochrome c-2
type: ProteinReference
xref: uniprot P84029 867
organism: Drosophila melanogaster

uniprot Q06507 483
type: UnificationXref
id: Q06507
db: uniprot

Apaf-1
type: Protein
entity reference: Apaf-1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

c-Jun
type: Protein
entity reference: c-Jun
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa10 916
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Bax
type: ProteinReference
xref: P00271
standard name: Bcl-2 associated x protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bax
comment: ENTITY_REFERENCE_NOTES=Long Name: Bcl-2 associated x protein Synonym: Synonym not specified Accession: P00271
member entity reference: Apoptosis regulator BAX
member entity reference: Uncharacterized protein
member entity reference: BCL2-associated X protein
member entity reference: BCL2-associated X, apoptosis regulator a

IGFR2 s22 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IGFR2
stoichiometric coefficient: 1.0

uniprot P17544 473
type: UnificationXref
id: P17544
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot H2R5K3 363
organism: Pan troglodytes

uniprot P16236 400
type: UnificationXref
id: P16236
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF466
xref: uniprot Q84UI5 186
organism: Oryza sativa

E3 ubiquitin-protein ligase XIAP
type: ProteinReference
xref: uniprot Q60989 505
organism: Mus musculus

uniprot P67939 217
type: UnificationXref
id: P67939
db: uniprot

c-Jun
type: Protein
entity reference: c-Jun
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa12 920
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BMG9 846
organism: Macaca mulatta

Diablo homolog, mitochondrial
type: ProteinReference
xref: uniprot Q9NR28 557
organism: Homo sapiens

uniprot P17156 789
type: UnificationXref
id: P17156
db: uniprot

FBJ murine osteosarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot F7EI91 652
xref: PTHR23351:SF4
organism: Xenopus tropicalis

BCL2 family apoptosis regulator BOK
type: ProteinReference
xref: PTHR11256:SF48
xref: uniprot F7AGS1 83
organism: Ornithorhynchus anatinus

uniprot F1R9V3 741
type: UnificationXref
id: F1R9V3
db: uniprot

uniprot Q9VSH3 277
type: UnificationXref
id: Q9VSH3
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Bcl_2-_Bik-RIGHT__Complex__Bcl_2_Bik_-_r97
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 1098
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 1097
participant stoichiometry: PARTICIPANT STOICHIOMETRY r97 1096
left: Bcl-2
left: Bik
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Bcl-2/Bik)

Bi1
type: ProteinReference
xref: P00277
standard name: Bax inhibitor-1
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bi1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Bax inhibitor-1 Synonym: Synonym not specified Accession: P00277
member entity reference: Bax inhibitor 1
member entity reference: AGAP005775-PA
member entity reference: Bax inhibitor-1 family protein
member entity reference: Uncharacterized protein
member entity reference: Transmembrane BAX inhibitor motif containing 6

P00290
type: UnificationXref
id: P00290
db: PANTHER Pathway Component

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot V5IKE7 192
xref: PTHR24055:SF158
organism: Neurospora crassa

P00292
type: UnificationXref
id: P00292
db: PANTHER Pathway Component

By Homology
type: RelationshipTypeVocabulary

P00291
type: UnificationXref
id: P00291
db: PANTHER Pathway Component

Apaf-1
type: Protein
entity reference: Apaf-1
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

RIP
type: ProteinReference
xref: P00315
standard name: Receptor interacting protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Receptor interacting protein Synonym: RIPK1,Receptor-interacting serine/threonine kinase 1 Accession: P00315
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.RIP
member entity reference: RIPK1 isoform 1
member entity reference: Receptor-interacting serine/threonine-protein kinase 1
member entity reference: Uncharacterized protein

uniprot Q06643 43
type: UnificationXref
id: Q06643
db: uniprot

P00298
type: UnificationXref
id: P00298
db: PANTHER Pathway Component

P00297
type: UnificationXref
id: P00297
db: PANTHER Pathway Component

uniprot P19974 861
type: UnificationXref
id: P19974
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Granzyme_B-_IGFR2-RIGHT__Complex__IGFR2_Granzyme_B_-_r111
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 1027
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 1028
participant stoichiometry: PARTICIPANT STOICHIOMETRY r111 1026
left: IGFR2
left: Granzyme B
interaction type: HETERODIMER_ASSOCIATION
right: Complex (IGFR2/Granzyme B)

uniprot H2PYQ3 759
type: UnificationXref
id: H2PYQ3
db: uniprot

P00299
type: UnificationXref
id: P00299
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot H3FYW1 764
xref: PTHR19375:SF457
organism: Pristionchus pacificus

P00294
type: UnificationXref
id: P00294
db: PANTHER Pathway Component

P00293
type: UnificationXref
id: P00293
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Caspase_9-RIGHT__Caspase_9-_r104
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 1047
participant stoichiometry: PARTICIPANT STOICHIOMETRY r104 1048
left: Caspase 9
interaction type: STATE_TRANSITION
right: Caspase 9

P00296
type: UnificationXref
id: P00296
db: PANTHER Pathway Component

uniprot A9JTJ5 723
type: UnificationXref
id: A9JTJ5
db: uniprot

Tumor necrosis factor receptor superfamily member 1A
type: ProteinReference
xref: uniprot P19438 340
xref: PTHR46861:SF1
organism: Homo sapiens

P00295
type: UnificationXref
id: P00295
db: PANTHER Pathway Component

uniprot F7FCJ3 602
type: UnificationXref
id: F7FCJ3
db: uniprot

uniprot P16054 686
type: UnificationXref
id: P16054
db: uniprot

Bcl-xL
type: ProteinReference
xref: P00257
standard name: Bcl2-related protein long isoform
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Bcl-xL
comment: ENTITY_REFERENCE_NOTES=Long Name: Bcl2-related protein long isoform Synonym: Synonym not specified Accession: P00257
member entity reference: Bcl-2-like protein 1
member entity reference: BCL2 like 1
member entity reference: BCL2-like 1

RIP
type: Protein
entity reference: RIP
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa6 968
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot F6Y4G8 231
type: UnificationXref
id: F6Y4G8
db: uniprot

PARTICIPANT STOICHIOMETRY r74 1016
type: Stoichiometry
physical entity: ATF
stoichiometric coefficient: 1.0

uniprot Q7JXB9 292
type: UnificationXref
id: Q7JXB9
db: uniprot

PARTICIPANT STOICHIOMETRY r74 1015
type: Stoichiometry
physical entity: ATF
stoichiometric coefficient: 1.0

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot P06761 771
organism: Rattus norvegicus

uniprot F7H6U5 318
type: UnificationXref
id: F7H6U5
db: uniprot

Tumor necrosis factor receptor superfamily member 1B
type: ProteinReference
xref: uniprot F7EAF8 331
xref: PTHR47386:SF1
organism: Macaca mulatta

DAXX s63 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DAXX
stoichiometric coefficient: 1.0

DAXX isoform 1
type: ProteinReference
xref: uniprot A0A2J8NYK5 376
xref: PTHR12766:SF7
organism: Pan troglodytes

uniprot Q7QHH7 535
type: UnificationXref
id: Q7QHH7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot A0A1D5QUZ8 141
organism: Macaca mulatta

Complex (TNFR1/TNF/ MADD)
type: Complex
component stoichiometry: MADD s29 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: TNF s28 sa24 STOICHIOMETRY ID COMPLEX
component: TNF
component: MADD
component: TNFR1
feature: COMPLEX BINDING FEATURE s206 a330 941
feature: COMPLEX BINDING FEATURE s206 a330 937
feature: COMPLEX BINDING FEATURE s206 a330 939
feature: ACTIVE 25
cellular location: intracellular

uniprot A0A2I3TDG1 105
type: UnificationXref
id: A0A2I3TDG1
db: uniprot

uniprot O65719 769
type: UnificationXref
id: O65719
db: uniprot

uniprot Q61161 136
type: UnificationXref
id: Q61161
db: uniprot

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__FADD-_TRADD-RIGHT__Complex__FADD_TRADD_-_r45
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1087
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1088
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 1089
left: FADD
left: TRADD
interaction type: HETERODIMER_ASSOCIATION
right: Complex (FADD/TRADD)

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q9WTQ0 704
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Bid-RIGHT__Bid-_r28
controller: Caspase 10

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 590

Heat shock 70 kDa protein 1-like
type: ProteinReference
xref: uniprot P34931 799
xref: PTHR19375:SF210
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase kinase
type: ProteinReference
xref: uniprot F6R1B6 601
organism: Xenopus tropicalis

ATF
type: Protein
entity reference: ATF
feature: ACTIVE 25
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Granzyme B
type: ProteinReference
xref: uniprot P10144 107
organism: Homo sapiens

uniprot F7BMG9 846
type: UnificationXref
id: F7BMG9
db: uniprot

uniprot H9FVU5 581
type: UnificationXref
id: H9FVU5
db: uniprot

uniprot F6PUU3 448
type: UnificationXref
id: F6PUU3
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Bax-_Bak-RIGHT__Complex__Bax_Bak_-_r95
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 1104
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 1102
participant stoichiometry: PARTICIPANT STOICHIOMETRY r95 1103
left: Bak
left: Bax
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Bax/Bak)

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 813

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Bax_Bak_-RIGHT__Bax-_Bak-_r96
controller: Bad

Thalassiosira pseudonana
type: BioSource
xref: ncbitaxon 35128 732

uniprot E2R2N2 147
type: UnificationXref
id: E2R2N2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11256:SF13
xref: uniprot F6U940 642
organism: Monodelphis domestica

GO GO:0005622 3
type: UnificationXref
id: GO:0005622
db: GO

uniprot Q07440 309
type: UnificationXref
id: Q07440
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G769 849
xref: PTHR11961:SF29
organism: Macaca mulatta

TNF s247 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TNF
stoichiometric coefficient: 1.0

uniprot P17879 790
type: UnificationXref
id: P17879
db: uniprot

uniprot A0A2I3T6T8 305
type: UnificationXref
id: A0A2I3T6T8
db: uniprot

PTHR19375:SF207
type: RelationshipXref
id: PTHR19375:SF207
db: PANTHER Family
relationship type: By Homology

uniprot Q5RK17 555
type: UnificationXref
id: Q5RK17
db: uniprot

Complex (Fos/c-Jun)
type: Complex
component stoichiometry: c Jun s15 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: Fos s14 sa11 STOICHIOMETRY ID COMPLEX
component: Fos
component: c-Jun
feature: COMPLEX BINDING FEATURE s123 a150 919
feature: COMPLEX BINDING FEATURE s123 a150 917
cellular location: nucleus

uniprot Q60823 73
type: UnificationXref
id: Q60823
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BD74 633
xref: PTHR48013:SF21
organism: Monodelphis domestica

uniprot K7BTC1 332
type: UnificationXref
id: K7BTC1
db: uniprot

uniprot Q13323 29
type: UnificationXref
id: Q13323
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Caspase_10-RIGHT__Caspase_10-_r49
controller: Complex (FADD/TRADD)

uniprot Q15628 708
type: UnificationXref
id: Q15628
db: uniprot

PARTICIPANT STOICHIOMETRY r61 1056
type: Stoichiometry
physical entity: NFkappaB
stoichiometric coefficient: 1.0

uniprot P45983 239
type: UnificationXref
id: P45983
db: uniprot

PARTICIPANT STOICHIOMETRY r61 1057
type: Stoichiometry
physical entity: NFkappaB
stoichiometric coefficient: 1.0

70 kDa heat shock protein
type: ProteinReference
xref: uniprot Q943K7 835
xref: PTHR19375:SF391
organism: Oryza sativa

uniprot A0A2I3SBZ3 426
type: UnificationXref
id: A0A2I3SBZ3
db: uniprot

PTHR19375:SF210
type: RelationshipXref
id: PTHR19375:SF210
db: PANTHER Family
relationship type: By Homology

uniprot F7HFY2 509
type: UnificationXref
id: F7HFY2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot H2QLB4 155
organism: Pan troglodytes

Tumor necrosis factor receptor superfamily member 10A
type: ProteinReference
xref: uniprot O00220 261
xref: PTHR46330:SF2
organism: Homo sapiens

PTHR19375:SF215
type: RelationshipXref
id: PTHR19375:SF215
db: PANTHER Family
relationship type: By Homology

SEK1
type: ProteinReference
xref: P00266
standard name: SAPK/ERK kinasae 1
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.SEK1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: SAPK/ERK kinasae 1 Synonym: JNK-activated kinase 1,JNKK1,MAPKK4,MEK4,MKK4,Mitogen activated protein kinase kinase 4 Accession: P00266
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase 4A

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

uniprot P04187 106
type: UnificationXref
id: P04187
db: uniprot

Eukaryotic translation initiation factor 2 subunit 1
type: ProteinReference
xref: uniprot P41374 527
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_IAP1,2-RIGHT__c_IAP1,2-_r103
controller: Smac/Diablo

MAPK
type: Protein
entity reference: MAPK
feature: MAPK s105 a131 rs1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

uniprot Q9I9E9 545
type: UnificationXref
id: Q9I9E9
db: uniprot

Apaf-1
type: ProteinReference
xref: P00301
standard name: Apoptosis protease activating factor-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.Apaf-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Apoptosis protease activating factor-1 Synonym: Synonym not specified Accession: P00301
member entity reference: Apoptotic protease-activating factor 1

uniprot Q90Z98 23
type: UnificationXref
id: Q90Z98
db: uniprot

uniprot H2QLU7 26
type: UnificationXref
id: H2QLU7
db: uniprot

Cyclic AMP-dependent transcription factor ATF-6 beta
type: ProteinReference
xref: uniprot Q99941 492
xref: PTHR46164:SF2
organism: Homo sapiens

STATE_TRANSITION_LEFT__PACT-RIGHT__PACT-_r116
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r116 1010
participant stoichiometry: PARTICIPANT STOICHIOMETRY r116 1009
left: PACT
interaction type: STATE_TRANSITION
right: PACT

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot A0A1D5Q5Z6 140
organism: Macaca mulatta

Bcl-2
type: Protein
entity reference: Bcl-2
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa17 954
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

NFKB inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot H2Q867 355
organism: Pan troglodytes

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P17252 687
organism: Homo sapiens

Tumor necrosis factor ligand superfamily member
type: ProteinReference
xref: uniprot A0A0U5J5G6 90
xref: PTHR11471:SF27
organism: Pan troglodytes

uniprot Q99JP0 609
type: UnificationXref
id: Q99JP0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RF71 761
xref: PTHR19375:SF223
organism: Pan troglodytes

uniprot A9RCV9 724
type: UnificationXref
id: A9RCV9
db: uniprot

BCL2 related protein A1
type: ProteinReference
xref: PTHR11256:SF10
xref: uniprot A0A2I3T6T8 305
organism: Pan troglodytes

uniprot Q12851 134
type: UnificationXref
id: Q12851
db: uniprot

Tumor necrosis factor ligand superfamily member
type: ProteinReference
xref: uniprot F6S9W7 91
xref: PTHR11471:SF27
organism: Macaca mulatta

XIAP
type: Protein
entity reference: XIAP
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Bcl-xL
type: Protein
entity reference: Bcl-xL
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Nuclear factor NF-kappa-B p100 subunit
type: ProteinReference
xref: PTHR24169:SF21
xref: uniprot Q9WTK5 412
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DD51 755
xref: PTHR19375:SF379
organism: Monodelphis domestica

STATE_TRANSITION
type: InteractionVocabulary

Proto-oncogene c-Rel
type: ProteinReference
xref: uniprot P16236 400
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2TVK8 439
organism: Gallus gallus

TRANSPORT
type: InteractionVocabulary

uniprot F7GNW3 395
type: UnificationXref
id: F7GNW3
db: uniprot

uniprot Q5A1D3 178
type: UnificationXref
id: Q5A1D3
db: uniprot

PTHR24055:SF196
type: RelationshipXref
id: PTHR24055:SF196
db: PANTHER Family
relationship type: By Homology

TNFR2 s250 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TNFR2
stoichiometric coefficient: 3.0

uniprot E1BK67 114
type: UnificationXref
id: E1BK67
db: uniprot

MAPK s114 a138 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q7PVR1 184
type: UnificationXref
id: Q7PVR1
db: uniprot

uniprot Q13546 639
type: UnificationXref
id: Q13546
db: uniprot

TRAIL R s16 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TRAIL-R
stoichiometric coefficient: 1.0

uniprot Q12933 519
type: UnificationXref
id: Q12933
db: uniprot

Heat shock protein 70
type: ProteinReference
xref: uniprot Q8IB24 830
xref: PTHR19375:SF395
organism: Plasmodium falciparum

uniprot Q9JIQ3 556
type: UnificationXref
id: Q9JIQ3
db: uniprot

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot Q5A1D3 178
organism: Candida albicans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ASK1-RIGHT__ASK1-_r67
controller: GCK

FADD
type: ProteinReference
xref: P00327
standard name: Fas associated death domain
comment: ENTITY_REFERENCE_NOTES=Long Name: Fas associated death domain Synonym: Synonym not specified Accession: P00327
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.FADD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: FAS-associated death domain protein

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Bcl_xL-RIGHT__Bcl_xL-_re78
controller: Diva

uniprot A8KBH6 660
type: UnificationXref
id: A8KBH6
db: uniprot

uniprot H2QY73 516
type: UnificationXref
id: H2QY73
db: uniprot

uniprot A9U4N3 729
type: UnificationXref
id: A9U4N3
db: uniprot

AIF
type: ProteinReference
xref: P00286
standard name: Apoptosis inducing factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Apoptosis inducing factor Synonym: Synonym not specified Accession: P00286
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.AIF
member entity reference: Apoptosis-inducing factor 1, mitochondrial
member entity reference: Putative apoptosis-inducing factor 1, mitochondrial
member entity reference: Apoptosis inducing factor mitochondria associated 1
member entity reference: Uncharacterized protein

Cyclic AMP-dependent transcription factor ATF-7
type: ProteinReference
xref: PTHR19304:SF10
xref: uniprot Q8R0S1 490
organism: Mus musculus

uniprot F7HUE9 547
type: UnificationXref
id: F7HUE9
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Bcl_xL-RIGHT__Bcl_xL-_re78
control type: INHIBITION
controller: Blk

uniprot Q76LT7 21
type: UnificationXref
id: Q76LT7
db: uniprot

Tumor necrosis factor receptor superfamily member 6
type: ProteinReference
xref: PTHR46874:SF1
xref: uniprot P25446 348
organism: Mus musculus

Bcl-2-related protein A1
type: ProteinReference
xref: PTHR11256:SF10
xref: uniprot Q16548 311
organism: Homo sapiens

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot E2R6T4 495
xref: PTHR11462:SF8
organism: Canis lupus familiaris

Tumor necrosis factor receptor superfamily member 6
type: ProteinReference
xref: PTHR46874:SF1
xref: uniprot P25445 347
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11961:SF12
xref: uniprot Q0TY36 871
organism: Phaeosphaeria nodorum

Caspase 3, apoptosis-related cysteine peptidase a
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot B8JK21 508
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Bax_Bak_-RIGHT__Bax-_Bak-_r96
controller: Bok

Activating transcription factor 2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot F1PCQ4 447
organism: Canis lupus familiaris

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 150

Bcl-2-like protein 10
type: ProteinReference
xref: PTHR11256:SF47
xref: uniprot Q9Z0F3 322
organism: Mus musculus

Interferon-inducible double-stranded RNA-dependent protein kinase activator A
type: ProteinReference
xref: uniprot Q4V8C7 297
xref: PTHR46205:SF2
organism: Rattus norvegicus

Lymphotoxin-alpha
type: ProteinReference
xref: uniprot Q06600 42
organism: Bos taurus

Endoplasmic reticulum chaperone BiP
type: ProteinReference
xref: PTHR19375:SF144
xref: uniprot P36604 801
organism: Schizosaccharomyces pombe

NFkappaB
type: ProteinReference
xref: P00297
standard name: Nuclear factor kappa-B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Nuclear factor kappa-B Synonym: Nuclear factor of kappa light chain gene enhancer in B cells Accession: P00297
comment: ENTITY_REFERENCE_ID_DESC=Apoptosis signaling pathway.PROTEIN.GENERIC.NF_kappa_B
member entity reference: Proto-oncogene c-Rel
member entity reference: Nuclear factor NF-kappa-B p105 subunit
member entity reference: Nuclear factor kappaB subunit p65
member entity reference: NFKB2 isoform 3
member entity reference: Nuclear factor NF-kappa-B p100 subunit
member entity reference: NF-kappaB transcription factor p65 subunit
member entity reference: NFKB2 protein
member entity reference: Uncharacterized protein
member entity reference: NFKB1 isoform 1
member entity reference: Nuclear factor kappa B subunit 2
member entity reference: Transcription factor p65
member entity reference: RELB proto-oncogene, NF-kB subunit
member entity reference: REL proto-oncogene, NF-kB subunit
member entity reference: Nuclear factor NF-kappa-B p105 subunit isoform 1
member entity reference: RELA isoform 1
member entity reference: Transcription factor RelB
member entity reference: RELA proto-oncogene, NF-kB subunit

Bi1
type: Protein
entity reference: Bi1
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

TNFR2
type: Protein
entity reference: TNFR2

Tumor necrosis factor receptor 1
type: ProteinReference
xref: uniprot G7N5L8 338
xref: PTHR46861:SF1
organism: Macaca mulatta

uniprot F6R8N3 59
type: UnificationXref
id: F6R8N3
db: uniprot

Bcl-2-related ovarian killer protein
type: ProteinReference
xref: PTHR11256:SF48
xref: uniprot Q9I8I2 88
organism: Gallus gallus

PIK3CG isoform 1
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot A0A2J8QY32 562
organism: Pan troglodytes

uniprot P31750 67
type: UnificationXref
id: P31750
db: uniprot

XIAP
type: Protein
entity reference: XIAP
feature: ACTIVE 25
cellular location: intracellular
comment: SPECIES_TYPE=PROTEIN

Cellular tumor antigen p53
type: ProteinReference
xref: PTHR11447:SF6
xref: uniprot P67939 217
organism: Bos taurus

uniprot P63086 169
type: UnificationXref
id: P63086
db: uniprot

Cytochrome c, somatic
type: ProteinReference
xref: PTHR11961:SF15
xref: uniprot P62898 865
organism: Rattus norvegicus

Cytochrome c
type: ProteinReference
xref: PTHR11961:SF15
xref: uniprot P62894 863
organism: Bos taurus

Cytochrome c, somatic
type: ProteinReference
xref: PTHR11961:SF15
xref: uniprot P62897 864
organism: Mus musculus