PARTICIPANT STOICHIOMETRY r1 212
type: Stoichiometry
physical entity: CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 211
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

uniprot O74916 163
type: UnificationXref
id: O74916
db: uniprot

PARTICIPANT STOICHIOMETRY r1 213
type: Stoichiometry
physical entity: N-acetylglutamate
stoichiometric coefficient: 1.0

Putative peptidase
type: ProteinReference
xref: uniprot Q9FCK3 178
organism: Streptomyces coelicolor

PARTICIPANT STOICHIOMETRY r1 210
type: Stoichiometry
physical entity: Acetyl-CoA
stoichiometric coefficient: 1.0

Acetylornithine deacetylase
type: ProteinReference
xref: uniprot Q8A1V9 173
organism: Bacteroides thetaiotaomicron

Argininosuccinate synthase
type: ProteinReference
xref: uniprot P14568 23
organism: Bos taurus

uniprot Q9X1Z4 180
type: UnificationXref
id: Q9X1Z4
db: uniprot

uniprot P05150 140
type: UnificationXref
id: P05150
db: uniprot

ncbitaxon 10090 26
type: UnificationXref
id: 10090
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QXP1 4
organism: Macaca mulatta

ncbitaxon 184922 129
type: UnificationXref
id: 184922
db: ncbitaxon

Giardia intestinalis
type: BioSource
xref: ncbitaxon 184922 129

N-acetylglutamate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q8R4H7 193
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 26

uniprot Q1K8F6 189
type: UnificationXref
id: Q1K8F6
db: uniprot

N-acetylglutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 7227 16
type: UnificationXref
id: 7227
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QNQ2 80
organism: Macaca mulatta

Probable argininosuccinate lyase
type: ProteinReference
xref: uniprot P50514 61
organism: Schizosaccharomyces pombe

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 28

uniprot Q7Q410 69
type: UnificationXref
id: Q7Q410
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 16

uniprot P96108 148
type: UnificationXref
id: P96108
db: uniprot

ncbitaxon 9031 54
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot Q59R31 67
type: UnificationXref
id: Q59R31
db: uniprot

ncbitaxon 243274 48
type: UnificationXref
id: 243274
db: ncbitaxon

AMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6QRQ6 131
type: UnificationXref
id: F6QRQ6
db: uniprot

uniprot P73257 63
type: UnificationXref
id: P73257
db: uniprot

ncbitaxon 10116 20
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot Q9RY70 158
type: UnificationXref
id: Q9RY70
db: uniprot

Argininosuccinate lyase
type: ProteinReference
xref: uniprot Q91YI0 74
organism: Mus musculus

uniprot P18185 104
type: UnificationXref
id: P18185
db: uniprot

Argininosuccinate lyase
type: ProteinReference
xref: uniprot Q8TR65 71
organism: Methanosarcina acetivorans

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot E2RTT6 128
organism: Giardia intestinalis

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P04076 55
type: UnificationXref
id: P04076
db: uniprot

Acetylornithine deacetylase
type: ProteinReference
xref: uniprot P23908 164
organism: Escherichia coli

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot Q58291 154
organism: Methanocaldococcus jannaschii

uniprot Q18621 168
type: UnificationXref
id: Q18621
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 151

Argininosuccinate lyase
type: ProteinReference
xref: uniprot P11447 58
organism: Escherichia coli

Ornithine carbamoyltransferase subunit F
type: ProteinReference
xref: uniprot P06960 141
organism: Escherichia coli

uniprot F7BNT2 133
type: UnificationXref
id: F7BNT2
db: uniprot

uniprot H2RBX6 50
type: UnificationXref
id: H2RBX6
db: uniprot

uniprot O67607 136
type: UnificationXref
id: O67607
db: uniprot

uniprot Q8ZY48 122
type: UnificationXref
id: Q8ZY48
db: uniprot

uniprot P11725 144
type: UnificationXref
id: P11725
db: uniprot

uniprot Q9HY84 41
type: UnificationXref
id: Q9HY84
db: uniprot

acetate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P03965 100
type: UnificationXref
id: P03965
db: uniprot

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot P38100 108
organism: Pseudomonas aeruginosa

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PPR8 49
organism: Canis lupus familiaris

N-acetylornithine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Argininosuccinate synthase
type: Protein
entity reference: Argininosuccinate synthase
comment: SPECIES_TYPE=PROTEIN

Argininosuccinate synthase
type: ProteinReference
xref: uniprot P16460 25
organism: Mus musculus

Argininosuccinate lyase
type: ProteinReference
xref: uniprot Q8ZU95 72
organism: Pyrobaculum aerophilum

uniprot Q8C196 118
type: UnificationXref
id: Q8C196
db: uniprot

2 ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ornithine carbamoyl transferase
type: ProteinReference
xref: P02846
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ornithine carbamoyl transferase Synonym: Synonym not specified Accession: P02846
comment: ENTITY_REFERENCE_ID_DESC=Arginine biosynthesis.PROTEIN.GENERIC.Ornithine carbamoyl_br_transferase
member entity reference: Uncharacterized protein
member entity reference: Ornithine carbamoyltransferase, mitochondrial
member entity reference: Ornithine carbamoyltransferase
member entity reference: Ornithine carbamoyltransferase subunit I
member entity reference: Ornithine carbamoyltransferase subunit F
member entity reference: Ornithine carbamoyltransferase, catabolic
member entity reference: Ornithine carbamoyltransferase, anabolic
member entity reference: Ornithine carbamoyltransferase, chloroplastic

uniprot P00968 99
type: UnificationXref
id: P00968
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__N_acetylglutamyl_semialdehyde-_glutamate-RIGHT__ketoglutarate-_N_acetylornithine-_r4
controller: N-acetylornithine aminotransferase

uniprot P18186 146
type: UnificationXref
id: P18186
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 7

uniprot Q8F2S6 190
type: UnificationXref
id: Q8F2S6
db: uniprot

uniprot P31317 147
type: UnificationXref
id: P31317
db: uniprot

uniprot P07259 102
type: UnificationXref
id: P07259
db: uniprot

uniprot P25994 105
type: UnificationXref
id: P25994
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 134

Acetylornithine deacetylase ArgE
type: ProteinReference
xref: uniprot Q7UM22 172
organism: Rhodopirellula baltica

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__argininosuccinate-RIGHT__arginine-_fumarate-_r8
controller: argininosuccinate lyase

STATE_TRANSITION_LEFT__carbamoyl_phosphate-_ornithine-RIGHT__citrulline-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 233
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 231
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 232
left: ornithine
left: carbamoyl phosphate
interaction type: STATE_TRANSITION
right: citrulline

Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
type: ProteinReference
xref: uniprot D4A8A0 83
organism: Rattus norvegicus

uniprot Q9YHY9 159
type: UnificationXref
id: Q9YHY9
db: uniprot

Argininosuccinate lyase
type: ProteinReference
xref: uniprot P04076 55
organism: Saccharomyces cerevisiae

Carbamoyl-phosphate synthase large chain, N-terminal section
type: ProteinReference
xref: uniprot Q58773 115
organism: Methanocaldococcus jannaschii

Argininosuccinate synthase
type: ProteinReference
xref: uniprot P24532 29
organism: Streptomyces coelicolor

uniprot E2RD27 127
type: UnificationXref
id: E2RD27
db: uniprot

Carbamoyl-phosphate synthase large chain, C-terminal section
type: ProteinReference
xref: uniprot Q58776 116
organism: Methanocaldococcus jannaschii

STATE_TRANSITION_LEFT__citrulline-_aspartate-_ATP-RIGHT__AMP-_argininosuccinate-_PPi-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 227
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 225
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 228
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 230
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 229
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 226
left: aspartate
left: citrulline
left: ATP
interaction type: STATE_TRANSITION
right: AMP
right: PPi
right: argininosuccinate

uniprot A0A1D5QNQ2 80
type: UnificationXref
id: A0A1D5QNQ2
db: uniprot

CAD protein
type: ProteinReference
xref: uniprot Q18990 111
organism: Caenorhabditis elegans

uniprot P04391 139
type: UnificationXref
id: P04391
db: uniprot

ncbitaxon 1111708 32
type: UnificationXref
id: 1111708
db: ncbitaxon

CPS1 isoform 4
type: ProteinReference
xref: uniprot K7C7B9 94
organism: Pan troglodytes

uniprot P05083 57
type: UnificationXref
id: P05083
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZKS9 132
organism: Macaca mulatta

Carbamoyl-phosphate synthase arginine-specific large chain
type: ProteinReference
xref: uniprot P03965 100
organism: Saccharomyces cerevisiae

ncbitaxon 83332 34
type: UnificationXref
id: 83332
db: ncbitaxon

uniprot Q93JF1 157
type: UnificationXref
id: Q93JF1
db: uniprot

uniprot Q9HMQ2 39
type: UnificationXref
id: Q9HMQ2
db: uniprot

Protein arg-6, mitochondrial
type: ProteinReference
xref: uniprot P54898 187
organism: Neurospora crassa

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot Q55497 153
organism: Synechocystis

uniprot Q8ZU95 72
type: UnificationXref
id: Q8ZU95
db: uniprot

N-acetylglutamate synthase
type: ProteinReference
xref: uniprot H2QD56 183
organism: Pan troglodytes

Argininosuccinate lyase
type: ProteinReference
xref: uniprot Q3SZJ0 65
organism: Bos taurus

uniprot Q9FCK3 178
type: UnificationXref
id: Q9FCK3
db: uniprot

Succinyl-diaminopimelate desuccinylase
type: ProteinReference
xref: uniprot Q9FBL9 177
organism: Streptomyces coelicolor

N-acetylglutamate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q8N159 192
organism: Homo sapiens

ncbitaxon 237561 68
type: UnificationXref
id: 237561
db: ncbitaxon

Succinyl-diaminopimelate desuccinylase
type: ProteinReference
xref: uniprot O66823 162
organism: Aquifex aeolicus

uniprot Q8ZW40 156
type: UnificationXref
id: Q8ZW40
db: uniprot

N-actetylornithine deacetylase
type: Protein
entity reference: N-actetylornithine deacetylase
comment: SPECIES_TYPE=PROTEIN

citrulline
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ornithine carbamoyltransferase subunit I
type: ProteinReference
xref: uniprot P04391 139
organism: Escherichia coli

glutamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Argininosuccinate lyase
type: ProteinReference
xref: uniprot P9WPY7 64
organism: Mycobacterium tuberculosis

Argininosuccinate synthase
type: ProteinReference
xref: uniprot Q9HY84 41
organism: Pseudomonas aeruginosa

Argininosuccinate synthase
type: ProteinReference
xref: uniprot Q9X2A1 47
organism: Thermotoga maritima

uniprot Q9FBL9 177
type: UnificationXref
id: Q9FBL9
db: uniprot

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q9KXR6 124
organism: Streptomyces coelicolor

ncbitaxon 9913 24
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot O67213 11
type: UnificationXref
id: O67213
db: uniprot

Carbamoyl-phosphate synthase [ammonia], mitochondrial
type: ProteinReference
xref: uniprot P07756 103
organism: Rattus norvegicus

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot E2RD27 127
organism: Canis lupus familiaris

Ornithine carbamoyltransferase, mitochondrial
type: ProteinReference
xref: uniprot Q9YHY9 159
organism: Gallus gallus

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q48296 152
type: UnificationXref
id: Q48296
db: uniprot

uniprot P65807 167
type: UnificationXref
id: P65807
db: uniprot

N-actetylornithine deacetylase
type: ProteinReference
xref: P02847
standard name: N-acetylornithine deacetylase
comment: ENTITY_REFERENCE_ID_DESC=Arginine biosynthesis.PROTEIN.GENERIC.N-actetylornithine_br_deacetylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: N-acetylornithine deacetylase Synonym: Synonym not specified Accession: P02847
member entity reference: Acetylornithine deacetylase
member entity reference: Uncharacterized protein YgeY
member entity reference: ArgE/DapE/Acy1 family protein
member entity reference: Succinyl-diaminopimelate desuccinylase, putative
member entity reference: Peptidase M20 domain-containing protein C757.05c
member entity reference: Putative peptidase
member entity reference: Acetylornithine deacetylase ArgE
member entity reference: Succinyl-diaminopimelate desuccinylase
member entity reference: Uncharacterized protein
member entity reference: N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase
member entity reference: Putative succinyl-diaminopimelate desuccinylase
member entity reference: Uncharacterized metallohydrolase YodQ

ncbitaxon 9606 18
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot P9WPK3 109
type: UnificationXref
id: P9WPK3
db: uniprot

uniprot P24532 29
type: UnificationXref
id: P24532
db: uniprot

uniprot Q9X2A1 47
type: UnificationXref
id: Q9X2A1
db: uniprot

N-acetylglutamylphosphate reductase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot P50514 61
type: UnificationXref
id: P50514
db: uniprot

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 10

Protein ura1
type: ProteinReference
xref: uniprot Q09794 110
organism: Schizosaccharomyces pombe

Argininosuccinate lyase
type: ProteinReference
xref: uniprot P40369 60
organism: Schizosaccharomyces pombe

uniprot H2QY18 6
type: UnificationXref
id: H2QY18
db: uniprot

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot Q8ZW40 156
organism: Pyrobaculum aerophilum

Bos taurus
type: BioSource
xref: ncbitaxon 9913 24

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 5

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 92

uniprot P77973 31
type: UnificationXref
id: P77973
db: uniprot

Carbamoyl phosphate synthase
type: Protein
entity reference: Carbamoyl phosphate synthase
comment: SPECIES_TYPE=PROTEIN

Ornithine carbamoyltransferase, mitochondrial
type: ProteinReference
xref: uniprot P11803 145
organism: Emericella nidulans

uniprot O67233 95
type: UnificationXref
id: O67233
db: uniprot

Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
type: ProteinReference
xref: uniprot F7E0R2 89
organism: Monodelphis domestica

Argininosuccinate lyase
type: ProteinReference
xref: uniprot P50987 62
organism: Pseudomonas aeruginosa

uniprot Q7UM22 172
type: UnificationXref
id: Q7UM22
db: uniprot

uniprot F7E0R2 89
type: UnificationXref
id: F7E0R2
db: uniprot

uniprot B2RQC6 82
type: UnificationXref
id: B2RQC6
db: uniprot

Argininosuccinate synthase
type: ProteinReference
xref: uniprot P9WPW7 33
organism: Mycobacterium tuberculosis

Carbamoyl-phosphate synthase [ammonia], mitochondrial
type: ProteinReference
xref: uniprot P31327 107
organism: Homo sapiens

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 38

Argininosuccinate lyase
type: ProteinReference
xref: uniprot P20673 59
organism: Rattus norvegicus

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot Q9RY70 158
organism: Deinococcus radiodurans

uniprot F1ML89 85
type: UnificationXref
id: F1ML89
db: uniprot

uniprot P9WPW7 33
type: UnificationXref
id: P9WPW7
db: uniprot

P02841
type: UnificationXref
id: P02841
db: PANTHER Pathway Component

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q8ZY48 122
organism: Pyrobaculum aerophilum

P02840
type: UnificationXref
id: P02840
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2__ATP-_H2O-_HCO3-_glutamine-RIGHT__carbamoyl_phosphate-_PO4-_glutamate-_2_ADP-_r10
controller: Carbamoyl phosphate synthase

Amino-acid acetyltransferase, mitochondrial
type: ProteinReference
xref: uniprot P40360 186
organism: Saccharomyces cerevisiae

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot Q8TKT5 155
organism: Methanosarcina acetivorans

uniprot Q09794 110
type: UnificationXref
id: Q09794
db: uniprot

uniprot P9WIT9 149
type: UnificationXref
id: P9WIT9
db: uniprot

ncbitaxon 44689 166
type: UnificationXref
id: 44689
db: ncbitaxon

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 12

uniprot O94313 98
type: UnificationXref
id: O94313
db: uniprot

Argininosuccinate lyase, chloroplastic
type: ProteinReference
xref: uniprot Q9LEU8 77
organism: Arabidopsis thaliana

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 3

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_N_acetylornithine-RIGHT__acetate-_ornithine-_r5
controller: N-actetylornithine deacetylase

N-acetylglutamyl semialdehyde
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ornithine carbamoyltransferase, anabolic
type: ProteinReference
xref: uniprot P11724 143
organism: Pseudomonas aeruginosa

Ornithine carbamoyltransferase, mitochondrial
type: ProteinReference
xref: uniprot P11725 144
organism: Mus musculus

uniprot O34347 9
type: UnificationXref
id: O34347
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q18621 168
organism: Caenorhabditis elegans

Ornithine carbamoyltransferase, mitochondrial
type: ProteinReference
xref: uniprot P31317 147
organism: Schizosaccharomyces pombe

Protein arg11, mitochondrial
type: ProteinReference
xref: uniprot P31318 185
organism: Schizosaccharomyces pombe

N-acetylglutamate synthase
type: ProteinReference
xref: uniprot D4A904 181
organism: Rattus norvegicus

uniprot P11724 143
type: UnificationXref
id: P11724
db: uniprot

Acetylglutamate kinase
type: ProteinReference
xref: uniprot Q8F2S6 190
organism: Leptospira interrogans

Argininosuccinate synthase
type: ProteinReference
xref: uniprot P77973 31
organism: Synechocystis

Argininosuccinate lyase
type: ProteinReference
xref: uniprot O34858 51
organism: Bacillus subtilis

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q55756 114
organism: Synechocystis

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 54

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot P00968 99
organism: Escherichia coli

Argininosuccinate lyase
type: ProteinReference
xref: uniprot P05083 57
organism: Gallus gallus

Argininosuccinate synthase
type: ProteinReference
xref: uniprot P00966 17
organism: Homo sapiens

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 73

ncbitaxon 100226 30
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot Q42601 113
type: UnificationXref
id: Q42601
db: uniprot

ArgE/DapE/Acy1 family protein
type: ProteinReference
xref: uniprot Q9RSU7 179
organism: Deinococcus radiodurans

Argininosuccinate synthase
type: ProteinReference
xref: P02840
comment: ENTITY_REFERENCE_ID_DESC=Arginine biosynthesis.PROTEIN.GENERIC.Argininosuccinate_br_synthase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Argininosuccinate synthase Synonym: Synonym not specified Accession: P02840
member entity reference: Argininosuccinate synthase
member entity reference: Argininosuccinate synthase, chloroplastic
member entity reference: Uncharacterized protein
member entity reference: ASS1 isoform 1
member entity reference: Argininosuccinate synthase 1

uniprot P11803 145
type: UnificationXref
id: P11803
db: uniprot

ncbitaxon 284812 14
type: UnificationXref
id: 284812
db: ncbitaxon

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 30

HCO3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 178306 73
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot O34858 51
type: UnificationXref
id: O34858
db: uniprot

uniprot F1PJF3 87
type: UnificationXref
id: F1PJF3
db: uniprot

ncbitaxon 8364 134
type: UnificationXref
id: 8364
db: ncbitaxon

STATE_TRANSITION
type: RelationshipTypeVocabulary

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r5 197
type: Stoichiometry
physical entity: ornithine
stoichiometric coefficient: 1.0

P02845
type: UnificationXref
id: P02845
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r5 196
type: Stoichiometry
physical entity: acetate
stoichiometric coefficient: 1.0

uniprot F1MVC0 86
type: UnificationXref
id: F1MVC0
db: uniprot

STATE_TRANSITION_LEFT__2__ATP-_H2O-_HCO3-_glutamine-RIGHT__carbamoyl_phosphate-_PO4-_glutamate-_2_ADP-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 221
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 214
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 217
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 220
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 216
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 219
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 218
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 215
left: H2O
left: 2 ATP
left: HCO3
left: glutamine
interaction type: STATE_TRANSITION
right: glutamate
right: PO4
right: carbamoyl phosphate
right: 2 ADP

P02848
type: UnificationXref
id: P02848
db: PANTHER Pathway Component

P02847
type: UnificationXref
id: P02847
db: PANTHER Pathway Component

P02846
type: UnificationXref
id: P02846
db: PANTHER Pathway Component

uniprot Q8N159 192
type: UnificationXref
id: Q8N159
db: uniprot

uniprot H2QD56 183
type: UnificationXref
id: H2QD56
db: uniprot

uniprot P20673 59
type: UnificationXref
id: P20673
db: uniprot

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot F7BNT2 133
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r5 195
type: Stoichiometry
physical entity: N-acetylornithine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 194
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot P08308 142
type: UnificationXref
id: P08308
db: uniprot

uniprot P04424 56
type: UnificationXref
id: P04424
db: uniprot

uniprot O66823 162
type: UnificationXref
id: O66823
db: uniprot

uniprot P16460 25
type: UnificationXref
id: P16460
db: uniprot

uniprot Q55756 114
type: UnificationXref
id: Q55756
db: uniprot

uniprot P27708 106
type: UnificationXref
id: P27708
db: uniprot

uniprot P00481 138
type: UnificationXref
id: P00481
db: uniprot

Uncharacterized protein, isoform B
type: ProteinReference
xref: uniprot Q9VLG9 79
organism: Drosophila melanogaster

ncbitaxon 227321 97
type: UnificationXref
id: 227321
db: ncbitaxon

argininosuccinate lyase
type: Protein
entity reference: argininosuccinate lyase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 243230 44
type: UnificationXref
id: 243230
db: ncbitaxon

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Carbamoyl-phosphate synthase [ammonia], mitochondrial
type: ProteinReference
xref: uniprot Q8C196 118
organism: Mus musculus

Argininosuccinate lyase
type: ProteinReference
xref: uniprot O67383 52
organism: Aquifex aeolicus

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 112

ASL isoform 1
type: ProteinReference
xref: uniprot H2RBX6 50
organism: Pan troglodytes

uniprot E2RAV2 84
type: UnificationXref
id: E2RAV2
db: uniprot

Succinyl-diaminopimelate desuccinylase, putative
type: ProteinReference
xref: uniprot Q9X1Z4 180
organism: Thermotoga maritima

uniprot Q9RWJ0 78
type: UnificationXref
id: Q9RWJ0
db: uniprot

Ornithine carbamoyl transferase
type: Protein
entity reference: Ornithine carbamoyl transferase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9RSU7 179
type: UnificationXref
id: Q9RSU7
db: uniprot

uniprot P00480 137
type: UnificationXref
id: P00480
db: uniprot

Putative succinyl-diaminopimelate desuccinylase
type: ProteinReference
xref: uniprot Q8A601 175
organism: Bacteroides thetaiotaomicron

Carbamoyl-phosphate synthase large chain, C-terminal section
type: ProteinReference
xref: uniprot O67233 95
organism: Aquifex aeolicus

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 42

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot P96108 148
organism: Thermotoga maritima

ASS1 isoform 1
type: ProteinReference
xref: uniprot H2QY18 6
organism: Pan troglodytes

uniprot K7C7B9 94
type: UnificationXref
id: K7C7B9
db: uniprot

ncbitaxon 559292 28
type: UnificationXref
id: 559292
db: ncbitaxon

N-acetylglutamate synthase
type: ProteinReference
xref: P02848
comment: ENTITY_REFERENCE_ID_DESC=Arginine biosynthesis.PROTEIN.GENERIC.N-acetylglutamate_br_synthase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: N-acetylglutamate synthase Synonym: Synonym not specified Accession: P02848
member entity reference: Protein ARG5,6, mitochondrial
member entity reference: Amino-acid acetyltransferase, mitochondrial
member entity reference: Acetylglutamate kinase
member entity reference: N-acetylglutamate synthase, mitochondrial
member entity reference: Protein arg11, mitochondrial
member entity reference: Protein arg-6, mitochondrial
member entity reference: N-acetylglutamate synthase
member entity reference: Uncharacterized protein

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 40

uniprot P40360 186
type: UnificationXref
id: P40360
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__citrulline-_aspartate-_ATP-RIGHT__AMP-_argininosuccinate-_PPi-_r7
controller: Argininosuccinate synthase

uniprot Q91YI0 74
type: UnificationXref
id: Q91YI0
db: uniprot

PARTICIPANT STOICHIOMETRY r4 201
type: Stoichiometry
physical entity: N-acetylornithine
stoichiometric coefficient: 1.0

uniprot H9ESN2 8
type: UnificationXref
id: H9ESN2
db: uniprot

Argininosuccinate synthase
type: ProteinReference
xref: uniprot O67213 11
organism: Aquifex aeolicus

PARTICIPANT STOICHIOMETRY r4 200
type: Stoichiometry
physical entity: ketoglutarate
stoichiometric coefficient: 1.0

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 70

STATE_TRANSITION_LEFT__ATP-_N_acetylglutamate-RIGHT__ADP-_N_acetylglutamyl_phosphate-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 207
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 208
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 206
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 209
left: N-acetylglutamate
left: ATP
interaction type: STATE_TRANSITION
right: N-acetylglutamyl phosphate
right: ADP

ketoglutarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8R4H7 193
type: UnificationXref
id: Q8R4H7
db: uniprot

uniprot P07756 103
type: UnificationXref
id: P07756
db: uniprot

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot O67607 136
organism: Aquifex aeolicus

STATE_TRANSITION_LEFT__H2O-_N_acetylornithine-RIGHT__acetate-_ornithine-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 195
left: H2O
left: N-acetylornithine
interaction type: STATE_TRANSITION
right: acetate
right: ornithine

uniprot O97069 15
type: UnificationXref
id: O97069
db: uniprot

uniprot P31327 107
type: UnificationXref
id: P31327
db: uniprot

uniprot P14568 23
type: UnificationXref
id: P14568
db: uniprot

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 48

N-acetylglutamate kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Carbamoyl phosphate synthase
type: ProteinReference
xref: P02845
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Carbamoyl phosphate synthase Synonym: Synonym not specified Accession: P02845
comment: ENTITY_REFERENCE_ID_DESC=Arginine biosynthesis.PROTEIN.GENERIC.Carbamoyl_br_phosphate_br_synthase
member entity reference: Carbamoyl-phosphate synthase large chain
member entity reference: Uncharacterized protein
member entity reference: Carbamoyl-phosphate synthase arginine-specific large chain
member entity reference: CAD protein
member entity reference: Protein ura1
member entity reference: Carbamoyl-phosphate synthase large chain, N-terminal section
member entity reference: Carbamoyl-phosphate synthase [ammonia], mitochondrial
member entity reference: CPS1 isoform 4
member entity reference: Carbamoyl-phosphate synthase large chain, chloroplastic
member entity reference: Carbamoyl-phosphate synthase large chain, C-terminal section
member entity reference: Carbamoyl-phosphate synthase pyrimidine-specific large chain
member entity reference: Carbamoyl-phosphate synthase 1
member entity reference: Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
member entity reference: AGAP000300-PA
member entity reference: Protein pyrABCN
member entity reference: Protein URA2

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q8RG86 119
organism: Fusobacterium nucleatum

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot P9WIT9 149
organism: Mycobacterium tuberculosis

Argininosuccinate lyase
type: ProteinReference
xref: uniprot P04424 56
organism: Homo sapiens

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 32

Argininosuccinate synthase
type: ProteinReference
xref: uniprot Q9HMQ2 39
organism: Halobacterium salinarum

PARTICIPANT STOICHIOMETRY r7 230
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

uniprot Q9HP43 123
type: UnificationXref
id: Q9HP43
db: uniprot

Argininosuccinate synthase
type: ProteinReference
xref: uniprot Q8TNY5 37
organism: Methanosarcina acetivorans

uniprot Q9WZ27 126
type: UnificationXref
id: Q9WZ27
db: uniprot

uniprot D4A8A0 83
type: UnificationXref
id: D4A8A0
db: uniprot

uniprot Q9LEU8 77
type: UnificationXref
id: Q9LEU8
db: uniprot

uniprot P40369 60
type: UnificationXref
id: P40369
db: uniprot

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q8TNY4 121
organism: Methanosarcina acetivorans

Delta-1 crystallin
type: ProteinReference
xref: uniprot P02521 53
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r8 222
type: Stoichiometry
physical entity: argininosuccinate
stoichiometric coefficient: 1.0

Argininosuccinate lyase
type: ProteinReference
xref: uniprot Q9HMQ3 75
organism: Halobacterium salinarum

Protein pyrABCN
type: ProteinReference
xref: uniprot O93937 96
organism: Emericella nidulans

ncbitaxon 208964 42
type: UnificationXref
id: 208964
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r8 224
type: Stoichiometry
physical entity: fumarate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 223
type: Stoichiometry
physical entity: arginine
stoichiometric coefficient: 1.0

Amino-acid acetyltransferase, mitochondrial
type: ProteinReference
xref: uniprot Q1K8F6 189
organism: Neurospora crassa

uniprot Q3SZJ0 65
type: UnificationXref
id: Q3SZJ0
db: uniprot

uniprot O31724 160
type: UnificationXref
id: O31724
db: uniprot

uniprot Q58776 116
type: UnificationXref
id: Q58776
db: uniprot

CAD protein
type: ProteinReference
xref: uniprot P05990 101
organism: Drosophila melanogaster

Uncharacterized metallohydrolase YodQ
type: ProteinReference
xref: uniprot O34984 161
organism: Bacillus subtilis

N-acetylglutamyl phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RAV2 84
organism: Canis lupus familiaris

uniprot P0A6E4 21
type: UnificationXref
id: P0A6E4
db: uniprot

Ornithine carbamoyltransferase, chloroplastic
type: ProteinReference
xref: uniprot O50039 135
organism: Arabidopsis thaliana

uniprot Q8A601 175
type: UnificationXref
id: Q8A601
db: uniprot

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9KXR6 124
type: UnificationXref
id: Q9KXR6
db: uniprot

uniprot P09034 19
type: UnificationXref
id: P09034
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 90

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Acetyl_CoA-_glutamate-RIGHT__CoA-_N_acetylglutamate-_r1
controller: N-acetylglutamate synthase

uniprot Q7S4G6 169
type: UnificationXref
id: Q7S4G6
db: uniprot

CAD protein
type: ProteinReference
xref: uniprot P27708 106
organism: Homo sapiens

uniprot F1MNG5 130
type: UnificationXref
id: F1MNG5
db: uniprot

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 174

Protein ARG5,6, mitochondrial
type: ProteinReference
xref: uniprot Q01217 188
organism: Saccharomyces cerevisiae

uniprot P54898 187
type: UnificationXref
id: P54898
db: uniprot

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r7 228
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

Peptidase M20 domain-containing protein C757.05c
type: ProteinReference
xref: uniprot O74916 163
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r7 229
type: Stoichiometry
physical entity: argininosuccinate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 226
type: Stoichiometry
physical entity: aspartate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 227
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 225
type: Stoichiometry
physical entity: citrulline
stoichiometric coefficient: 1.0

ncbitaxon 226186 174
type: UnificationXref
id: 226186
db: ncbitaxon

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot Q1K5I2 150
organism: Neurospora crassa

uniprot Q8A1V9 173
type: UnificationXref
id: Q8A1V9
db: uniprot

N-acetylglutamate synthase
type: Protein
entity reference: N-acetylglutamate synthase
comment: SPECIES_TYPE=PROTEIN

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 14

Argininosuccinate synthase
type: ProteinReference
xref: uniprot Q60174 35
organism: Methanocaldococcus jannaschii

uniprot Q55497 153
type: UnificationXref
id: Q55497
db: uniprot

2 ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O94354 13
type: UnificationXref
id: O94354
db: uniprot

uniprot Q18990 111
type: UnificationXref
id: Q18990
db: uniprot

carbamoyl phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P22768 27
type: UnificationXref
id: P22768
db: uniprot

uniprot P9WPY7 64
type: UnificationXref
id: P9WPY7
db: uniprot

uniprot F7A376 182
type: UnificationXref
id: F7A376
db: uniprot

PANTHER Pathway P02728 1
type: UnificationXref
id: P02728
db: PANTHER Pathway

Ornithine carbamoyltransferase, mitochondrial
type: ProteinReference
xref: uniprot P00481 138
organism: Rattus norvegicus

Ornithine carbamoyltransferase, mitochondrial
type: ProteinReference
xref: uniprot P00480 137
organism: Homo sapiens

uniprot F7B8D5 88
type: UnificationXref
id: F7B8D5
db: uniprot

uniprot Q8TKT5 155
type: UnificationXref
id: Q8TKT5
db: uniprot

ncbitaxon 9258 92
type: UnificationXref
id: 9258
db: ncbitaxon

ncbitaxon 83333 22
type: UnificationXref
id: 83333
db: ncbitaxon

Argininosuccinate synthase, chloroplastic
type: ProteinReference
xref: uniprot Q9SZX3 45
organism: Arabidopsis thaliana

AGAP008141-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q410 69
organism: Anopheles gambiae

Arginine biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__ATP-_N_acetylglutamate-RIGHT__ADP-_N_acetylglutamyl_phosphate-_r2
pathway component: STATE_TRANSITION_LEFT__NADPH-_N_acetylglutamyl_phosphate-RIGHT__N_acetylglutamyl_semialdehyde-_NADP-_r3
pathway component: STATE_TRANSITION_LEFT__carbamoyl_phosphate-_ornithine-RIGHT__citrulline-_r6
pathway component: STATE_TRANSITION_LEFT__citrulline-_aspartate-_ATP-RIGHT__AMP-_argininosuccinate-_PPi-_r7
pathway component: STATE_TRANSITION_LEFT__argininosuccinate-RIGHT__arginine-_fumarate-_r8
pathway component: STATE_TRANSITION_LEFT__Acetyl_CoA-_glutamate-RIGHT__CoA-_N_acetylglutamate-_r1
pathway component: STATE_TRANSITION_LEFT__H2O-_N_acetylornithine-RIGHT__acetate-_ornithine-_r5
pathway component: STATE_TRANSITION_LEFT__N_acetylglutamyl_semialdehyde-_glutamate-RIGHT__ketoglutarate-_N_acetylornithine-_r4
pathway component: STATE_TRANSITION_LEFT__2__ATP-_H2O-_HCO3-_glutamine-RIGHT__carbamoyl_phosphate-_PO4-_glutamate-_2_ADP-_r10
xref: PANTHER Pathway P02728 1
comment: MODEL_NOTES=Prokaryote biosynthesis of the amino acid arginine critical for protein biosynthesis. Website=www.biocyc.org/Ecoli/Pathways/ free text=Biochemistry (text) Voet and Voet

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 191

STATE_TRANSITION_LEFT__NADPH-_N_acetylglutamyl_phosphate-RIGHT__N_acetylglutamyl_semialdehyde-_NADP-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 205
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 204
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 202
left: N-acetylglutamyl phosphate
left: NADPH
interaction type: STATE_TRANSITION
right: N-acetylglutamyl semialdehyde
right: NADP

STATE_TRANSITION_LEFT__N_acetylglutamyl_semialdehyde-_glutamate-RIGHT__ketoglutarate-_N_acetylornithine-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 200
left: glutamate
left: N-acetylglutamyl semialdehyde
interaction type: STATE_TRANSITION
right: ketoglutarate
right: N-acetylornithine

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 44

Acetyl-CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 18

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2I3TBT7 81
organism: Pan troglodytes

uniprot Q1K5I2 150
type: UnificationXref
id: Q1K5I2
db: uniprot

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 36

ncbitaxon 189518 191
type: UnificationXref
id: 189518
db: ncbitaxon

uniprot Q9RWJ4 43
type: UnificationXref
id: Q9RWJ4
db: uniprot

uniprot Q9SZX3 45
type: UnificationXref
id: Q9SZX3
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 46

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q9RWK0 125
organism: Deinococcus radiodurans

fumarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7FS26 93
type: UnificationXref
id: F7FS26
db: uniprot

Carbamoyl-phosphate synthase arginine-specific large chain
type: ProteinReference
xref: uniprot P18185 104
organism: Bacillus subtilis

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot P18186 146
organism: Bacillus subtilis

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot F6QRQ6 131
organism: Ornithorhynchus anatinus

aspartate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 34

ncbitaxon 224324 12
type: UnificationXref
id: 224324
db: ncbitaxon

uniprot P23908 164
type: UnificationXref
id: P23908
db: uniprot

uniprot F6ZKS9 132
type: UnificationXref
id: F6ZKS9
db: uniprot

Uncharacterized protein YgeY
type: ProteinReference
xref: uniprot P65807 167
organism: Escherichia coli

Argininosuccinate lyase
type: ProteinReference
xref: uniprot Q9RWJ0 78
organism: Deinococcus radiodurans

uniprot D4A904 181
type: UnificationXref
id: D4A904
db: uniprot

argininosuccinate lyase
type: ProteinReference
xref: P02841
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: argininosuccinate lyase Synonym: Synonym not specified Accession: P02841
comment: ENTITY_REFERENCE_ID_DESC=Arginine biosynthesis.PROTEIN.GENERIC.argininosuccinate_br_lyase
member entity reference: Argininosuccinate lyase
member entity reference: Argininosuccinate lyase, chloroplastic
member entity reference: Delta-1 crystallin
member entity reference: Probable argininosuccinate lyase
member entity reference: AGAP008141-PA (Fragment)
member entity reference: Uncharacterized protein, isoform B
member entity reference: Uncharacterized protein
member entity reference: ASL isoform 1

uniprot Q9L1B1 76
type: UnificationXref
id: Q9L1B1
db: uniprot

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot P05150 140
organism: Saccharomyces cerevisiae

uniprot Q58201 66
type: UnificationXref
id: Q58201
db: uniprot

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 22

Argininosuccinate synthase
type: ProteinReference
xref: uniprot Q9RWJ4 43
organism: Deinococcus radiodurans

Ornithine carbamoyltransferase
type: ProteinReference
xref: uniprot Q93JF1 157
organism: Streptomyces coelicolor

ncbitaxon 9615 3
type: UnificationXref
id: 9615
db: ncbitaxon

ncbitaxon 243232 36
type: UnificationXref
id: 243232
db: ncbitaxon

Carbamoyl-phosphate synthase 1
type: ProteinReference
xref: uniprot F1PJF3 87
organism: Canis lupus familiaris

argininosuccinate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q9HP43 123
organism: Halobacterium salinarum

uniprot Q58291 154
type: UnificationXref
id: Q58291
db: uniprot

ncbitaxon 224308 10
type: UnificationXref
id: 224308
db: ncbitaxon

Carbamoyl-phosphate synthase large chain, chloroplastic
type: ProteinReference
xref: uniprot Q42601 113
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r3 202
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 203
type: Stoichiometry
physical entity: N-acetylglutamyl phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 204
type: Stoichiometry
physical entity: N-acetylglutamyl semialdehyde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 205
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

uniprot Q9VLG9 79
type: UnificationXref
id: Q9VLG9
db: uniprot

CAD protein
type: ProteinReference
xref: uniprot B2RQC6 82
organism: Mus musculus

Carbamoyl-phosphate synthase arginine-specific large chain
type: ProteinReference
xref: uniprot O94313 98
organism: Schizosaccharomyces pombe

Argininosuccinate synthase
type: ProteinReference
xref: uniprot P09034 19
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MVC0 86
organism: Bos taurus

ncbitaxon 190304 120
type: UnificationXref
id: 190304
db: ncbitaxon

uniprot E2RTT6 128
type: UnificationXref
id: E2RTT6
db: uniprot

ncbitaxon 9544 5
type: UnificationXref
id: 9544
db: ncbitaxon

AGAP000300-PA
type: ProteinReference
xref: uniprot Q7QF47 117
organism: Anopheles gambiae

STATE_TRANSITION_LEFT__Acetyl_CoA-_glutamate-RIGHT__CoA-_N_acetylglutamate-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 211
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 213
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 210
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 212
left: glutamate
left: Acetyl-CoA
interaction type: STATE_TRANSITION
right: CoA
right: N-acetylglutamate

uniprot P02521 53
type: UnificationXref
id: P02521
db: uniprot

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 120

Uncharacterized protein
type: ProteinReference
xref: uniprot F7B8D5 88
organism: Macaca mulatta

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 166

Amino-acid acetyltransferase, mitochondrial
type: ProteinReference
xref: uniprot O94330 184
organism: Schizosaccharomyces pombe

uniprot A0A2I3TBT7 81
type: UnificationXref
id: A0A2I3TBT7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_N_acetylglutamate-RIGHT__ADP-_N_acetylglutamyl_phosphate-_r2
controller: N-acetylglutamate kinase

uniprot P06960 141
type: UnificationXref
id: P06960
db: uniprot

PARTICIPANT STOICHIOMETRY r4 198
type: Stoichiometry
physical entity: N-acetylglutamyl semialdehyde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 199
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

ArgE/DapE/Acy1 family protein
type: ProteinReference
xref: uniprot Q7UJ49 170
organism: Rhodopirellula baltica

CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RWK0 125
type: UnificationXref
id: Q9RWK0
db: uniprot

ncbitaxon 9598 7
type: UnificationXref
id: 9598
db: ncbitaxon

N-acetylornithine aminotransferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

ornithine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Argininosuccinate synthase
type: ProteinReference
xref: uniprot O34347 9
organism: Bacillus subtilis

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q9WZ27 126
organism: Thermotoga maritima

Argininosuccinate synthase
type: ProteinReference
xref: uniprot H9ESN2 8
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r10 221
type: Stoichiometry
physical entity: 2 ADP
stoichiometric coefficient: 1.0

Argininosuccinate lyase
type: ProteinReference
xref: uniprot P73257 63
organism: Synechocystis

PARTICIPANT STOICHIOMETRY r10 220
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

uniprot Q8RG86 119
type: UnificationXref
id: Q8RG86
db: uniprot

Argininosuccinate lyase
type: ProteinReference
xref: uniprot Q9L1B1 76
organism: Streptomyces coelicolor

arginine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8TNY4 121
type: UnificationXref
id: Q8TNY4
db: uniprot

uniprot Q9HMQ3 75
type: UnificationXref
id: Q9HMQ3
db: uniprot

uniprot F7FKP7 91
type: UnificationXref
id: F7FKP7
db: uniprot

uniprot Q7QF47 117
type: UnificationXref
id: Q7QF47
db: uniprot

uniprot O67383 52
type: UnificationXref
id: O67383
db: uniprot

uniprot P38100 108
type: UnificationXref
id: P38100
db: uniprot

uniprot P50987 62
type: UnificationXref
id: P50987
db: uniprot

uniprot Q8TNY5 37
type: UnificationXref
id: Q8TNY5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH-_N_acetylglutamyl_phosphate-RIGHT__N_acetylglutamyl_semialdehyde-_NADP-_r3
controller: N-acetylglutamylphosphate reductase

uniprot P11447 58
type: UnificationXref
id: P11447
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 20

uniprot E2QU08 2
type: UnificationXref
id: E2QU08
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1ML89 85
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r10 219
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 217
type: Stoichiometry
physical entity: glutamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 218
type: Stoichiometry
physical entity: carbamoyl phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 215
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 216
type: Stoichiometry
physical entity: HCO3
stoichiometric coefficient: 1.0

Ornithine carbamoyltransferase, mitochondrial
type: ProteinReference
xref: uniprot F1MNG5 130
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r10 214
type: Stoichiometry
physical entity: 2 ATP
stoichiometric coefficient: 1.0

uniprot O94330 184
type: UnificationXref
id: O94330
db: uniprot

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 171

uniprot P31318 185
type: UnificationXref
id: P31318
db: uniprot

PARTICIPANT STOICHIOMETRY r6 231
type: Stoichiometry
physical entity: carbamoyl phosphate
stoichiometric coefficient: 1.0

ncbitaxon 188937 38
type: UnificationXref
id: 188937
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r6 233
type: Stoichiometry
physical entity: citrulline
stoichiometric coefficient: 1.0

Ornithine carbamoyltransferase, catabolic
type: ProteinReference
xref: uniprot Q48296 152
organism: Halobacterium salinarum

PARTICIPANT STOICHIOMETRY r6 232
type: Stoichiometry
physical entity: ornithine
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: InteractionVocabulary

uniprot F6QXP1 4
type: UnificationXref
id: F6QXP1
db: uniprot

uniprot P05990 101
type: UnificationXref
id: P05990
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A376 182
organism: Macaca mulatta

Argininosuccinate synthase
type: ProteinReference
xref: uniprot O94354 13
organism: Schizosaccharomyces pombe

Argininosuccinate synthase
type: ProteinReference
xref: uniprot O97069 15
organism: Drosophila melanogaster

ncbitaxon 13616 90
type: UnificationXref
id: 13616
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FS26 93
organism: Monodelphis domestica

uniprot Q01217 188
type: UnificationXref
id: Q01217
db: uniprot

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Acetylornithine deacetylase
type: ProteinReference
xref: uniprot Q9C5C4 176
organism: Arabidopsis thaliana

uniprot Q58773 115
type: UnificationXref
id: Q58773
db: uniprot

Candida albicans
type: BioSource
xref: ncbitaxon 237561 68

Argininosuccinate synthase
type: ProteinReference
xref: uniprot P22768 27
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FKP7 91
organism: Ornithorhynchus anatinus

STATE_TRANSITION_LEFT__argininosuccinate-RIGHT__arginine-_fumarate-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 222
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 223
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 224
left: argininosuccinate
interaction type: STATE_TRANSITION
right: arginine
right: fumarate

uniprot Q8TR65 71
type: UnificationXref
id: Q8TR65
db: uniprot

Argininosuccinate lyase
type: ProteinReference
xref: uniprot Q58201 66
organism: Methanocaldococcus jannaschii

ncbitaxon 64091 40
type: UnificationXref
id: 64091
db: ncbitaxon

N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase
type: ProteinReference
xref: uniprot O31724 160
organism: Bacillus subtilis

Acetylornithine deacetylase
type: ProteinReference
xref: uniprot Q7S4G6 169
organism: Neurospora crassa

uniprot O50039 135
type: UnificationXref
id: O50039
db: uniprot

uniprot Q7UJ49 170
type: UnificationXref
id: Q7UJ49
db: uniprot

PARTICIPANT STOICHIOMETRY r2 206
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__carbamoyl_phosphate-_ornithine-RIGHT__citrulline-_r6
controller: Ornithine carbamoyl transferase

PARTICIPANT STOICHIOMETRY r2 207
type: Stoichiometry
physical entity: N-acetylglutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 208
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot P9WPK3 109
organism: Mycobacterium tuberculosis

PARTICIPANT STOICHIOMETRY r2 209
type: Stoichiometry
physical entity: N-acetylglutamyl phosphate
stoichiometric coefficient: 1.0

uniprot O93937 96
type: UnificationXref
id: O93937
db: uniprot

uniprot P00966 17
type: UnificationXref
id: P00966
db: uniprot

Ornithine carbamoyltransferase, catabolic
type: ProteinReference
xref: uniprot P08308 142
organism: Pseudomonas aeruginosa

Carbamoyl-phosphate synthase pyrimidine-specific large chain
type: ProteinReference
xref: uniprot P25994 105
organism: Bacillus subtilis

uniprot Q60174 35
type: UnificationXref
id: Q60174
db: uniprot

Protein URA2
type: ProteinReference
xref: uniprot P07259 102
organism: Saccharomyces cerevisiae

uniprot F1PPR8 49
type: UnificationXref
id: F1PPR8
db: uniprot

uniprot Q9C5C4 176
type: UnificationXref
id: Q9C5C4
db: uniprot

ncbitaxon 6239 112
type: UnificationXref
id: 6239
db: ncbitaxon

ncbitaxon 367110 151
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot O34984 161
type: UnificationXref
id: O34984
db: uniprot

ncbitaxon 7165 70
type: UnificationXref
id: 7165
db: ncbitaxon

Argininosuccinate synthase
type: ProteinReference
xref: uniprot P0A6E4 21
organism: Escherichia coli

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 97

Argininosuccinate synthase 1
type: ProteinReference
xref: uniprot E2QU08 2
organism: Canis lupus familiaris

Argininosuccinate lyase
type: ProteinReference
xref: uniprot Q59R31 67
organism: Candida albicans

Acetylornithine deacetylase
type: ProteinReference
xref: uniprot P54638 165
organism: Dictyostelium discoideum

ncbitaxon 3702 46
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot P54638 165
type: UnificationXref
id: P54638
db: uniprot

ncbitaxon 243090 171
type: UnificationXref
id: 243090
db: ncbitaxon