PARTICIPANT STOICHIOMETRY r1 69
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q95ZW2 47
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r1 68
type: Stoichiometry
physical entity: ascorbate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_3_ketogulonate-RIGHT__ADP-_3_ketogulonate_6_phosphate-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 64
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 65
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 66
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 67
left: 3-ketogulonate
left: ATP
interaction type: STATE_TRANSITION
right: 3-ketogulonate-6-phosphate
right: ADP

ncbitaxon 100226 53
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot O34557 22
type: UnificationXref
id: O34557
db: uniprot

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q8F3K8 39
organism: Leptospira interrogans

PARTICIPANT STOICHIOMETRY r2 67
type: Stoichiometry
physical entity: 3-ketogulonate-6-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 66
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

L-xylulose-5-phosphate-3-epimerase
type: ProteinReference
xref: P02852
comment: ENTITY_REFERENCE_NOTES=Long Name: L-xylulose-5-phosphate-3-epimerase Synonym: Synonym not specified Accession: P02852
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Ascorbate degradation.PROTEIN.GENERIC.L-xylulose-5-_br_phosphate-3-epimerase
member entity reference: Ribulose-phosphate 3-epimerase, chloroplastic
member entity reference: Ribulose-phosphate 3-epimerase
member entity reference: D-allulose-6-phosphate 3-epimerase
member entity reference: Uncharacterized protein
member entity reference: D-ribulose-5-phosphate-3-epimerase
member entity reference: Protein SgcE

PARTICIPANT STOICHIOMETRY r2 65
type: Stoichiometry
physical entity: 3-ketogulonate
stoichiometric coefficient: 1.0

uniprot P39306 7
type: UnificationXref
id: P39306
db: uniprot

PARTICIPANT STOICHIOMETRY r2 64
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q9L0Z5 52
organism: Streptomyces coelicolor

uniprot Q94K13 45
type: UnificationXref
id: Q94K13
db: uniprot

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 34

uniprot Q9L0Z5 52
type: UnificationXref
id: Q9L0Z5
db: uniprot

uniprot Q7NFH7 33
type: UnificationXref
id: Q7NFH7
db: uniprot

3-ketogulonate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

3-keto-L-gulonate-6-phosphate decarboxylase
type: Protein
comment: SPECIES_TYPE=PROTEIN

L-ribulose-5-phosphate 4-epimerase SgbE
type: ProteinReference
xref: uniprot P37680 6
organism: Escherichia coli

PARTICIPANT STOICHIOMETRY r4 74
type: Stoichiometry
physical entity: ribulose-5-phosphate
stoichiometric coefficient: 1.0

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r4 73
type: Stoichiometry
physical entity: L-xylulose-5-phosphate
stoichiometric coefficient: 1.0

L-ribulose-5-phosphate-4-epimerase
type: Protein
entity reference: L-ribulose-5-phosphate-4-epimerase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9RUI5 54
type: UnificationXref
id: Q9RUI5
db: uniprot

L-ribulose-5-phosphate 4-epimerase
type: ProteinReference
xref: uniprot P94525 8
organism: Bacillus subtilis

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q9RUI5 54
organism: Deinococcus radiodurans

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 9

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_3_ketogulonate-RIGHT__ADP-_3_ketogulonate_6_phosphate-_r2
controller: L-xylulose kinase

ncbitaxon 9606 50
type: UnificationXref
id: 9606
db: ncbitaxon

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 42

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot F7FDW3 18
organism: Monodelphis domestica

ncbitaxon 243230 55
type: UnificationXref
id: 243230
db: ncbitaxon

L-xylulose-5-phosphate-3-epimerase
type: Protein
entity reference: L-xylulose-5-phosphate-3-epimerase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 83333 3
type: UnificationXref
id: 83333
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__L_xylulose_5_phosphate-RIGHT__ribulose_5_phosphate-_r4
controller: L-xylulose-5-phosphate-3-epimerase

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 13

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q96AT9 49
organism: Homo sapiens

uniprot A0A2I3T655 14
type: UnificationXref
id: A0A2I3T655
db: uniprot

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 26

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot P46969 29
organism: Saccharomyces cerevisiae

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 58

Mus musculus
type: BioSource
xref: ncbitaxon 10090 44

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot F6V404 16
organism: Canis lupus familiaris

ribulose-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot O67098 23
organism: Aquifex aeolicus

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q7UX51 35
organism: Rhodopirellula baltica

uniprot P39362 28
type: UnificationXref
id: P39362
db: uniprot

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot A0A0G2JW38 10
organism: Rattus norvegicus

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 30

D-ribulose-5-phosphate-3-epimerase
type: ProteinReference
xref: uniprot Q9SAU2 56
organism: Arabidopsis thaliana

ncbitaxon 272561 26
type: UnificationXref
id: 272561
db: ncbitaxon

PANTHER Pathway P02729 1
type: UnificationXref
id: P02729
db: PANTHER Pathway

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

ncbitaxon 189518 40
type: UnificationXref
id: 189518
db: ncbitaxon

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot O14105 20
organism: Schizosaccharomyces pombe

L-ribulose-5-phosphate 4-epimerase AraD
type: ProteinReference
xref: uniprot P08203 2
xref: PTHR22789:SF15
organism: Escherichia coli

STATE_TRANSITION_LEFT__3_ketogulonate_6_phosphate-RIGHT__L_xylulose_5_phosphate-_CO2-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 63
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 61
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 62
left: 3-ketogulonate-6-phosphate
interaction type: STATE_TRANSITION
right: L-xylulose-5-phosphate
right: CO2

uniprot Q6PBW9 31
type: UnificationXref
id: Q6PBW9
db: uniprot

uniprot Q8RFL5 41
type: UnificationXref
id: Q8RFL5
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 11

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 24

uniprot Q8A0S5 37
type: UnificationXref
id: Q8A0S5
db: uniprot

ncbitaxon 3702 46
type: UnificationXref
id: 3702
db: ncbitaxon

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 17

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 19

3-ketogulonate-6-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

L-xylulose kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r1 70
type: Stoichiometry
physical entity: 3-ketogulonate
stoichiometric coefficient: 1.0

uniprot P08203 2
type: UnificationXref
id: P08203
db: uniprot

uniprot P32719 27
type: UnificationXref
id: P32719
db: uniprot

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 38

PARTICIPANT STOICHIOMETRY r5 71
type: Stoichiometry
physical entity: ribulose-5-phosphate
stoichiometric coefficient: 1.0

ncbitaxon 9598 15
type: UnificationXref
id: 9598
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r5 72
type: Stoichiometry
physical entity: D-xylulose-5-phosphate
stoichiometric coefficient: 1.0

uniprot F6V404 16
type: UnificationXref
id: F6V404
db: uniprot

D-xylulose-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 224324 24
type: UnificationXref
id: 224324
db: ncbitaxon

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

ncbitaxon 13616 19
type: UnificationXref
id: 13616
db: ncbitaxon

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 21

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q6PBW9 31
organism: Danio rerio

uniprot P37680 6
type: UnificationXref
id: P37680
db: uniprot

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 36

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 53

uniprot O67098 23
type: UnificationXref
id: O67098
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2I3T655 14
organism: Pan troglodytes

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q8RFL5 41
organism: Fusobacterium nucleatum

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 15

ncbitaxon 224308 9
type: UnificationXref
id: 224308
db: ncbitaxon

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ribulose_5_phosphate-RIGHT__D_xylulose_5_phosphate-_r5
controller: L-ribulose-5-phosphate-4-epimerase

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q94K13 45
organism: Arabidopsis thaliana

L-ribulose-5-phosphate-4-epimerase
type: ProteinReference
xref: P02851
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: L-ribulose-5-phosphate-4-epimerase Synonym: Synonym not specified Accession: P02851
comment: ENTITY_REFERENCE_ID_DESC=Ascorbate degradation.PROTEIN.GENERIC.L-ribulose-5-_br_phosphate-4-epimerase
member entity reference: L-ribulose-5-phosphate 4-epimerase UlaF
member entity reference: L-ribulose-5-phosphate 4-epimerase AraD
member entity reference: L-ribulose-5-phosphate 4-epimerase SgbE
member entity reference: L-ribulose-5-phosphate 4-epimerase

PARTICIPANT STOICHIOMETRY r3 63
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 62
type: Stoichiometry
physical entity: L-xylulose-5-phosphate
stoichiometric coefficient: 1.0

uniprot O14105 20
type: UnificationXref
id: O14105
db: uniprot

Protein SgcE
type: ProteinReference
xref: uniprot P39362 28
organism: Escherichia coli

PARTICIPANT STOICHIOMETRY r3 61
type: Stoichiometry
physical entity: 3-ketogulonate-6-phosphate
stoichiometric coefficient: 1.0

ncbitaxon 243274 58
type: UnificationXref
id: 243274
db: ncbitaxon

uniprot O84123 25
type: UnificationXref
id: O84123
db: uniprot

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q8A0S5 37
organism: Bacteroides thetaiotaomicron

PTHR22789:SF15
type: RelationshipXref
id: PTHR22789:SF15
db: PANTHER Family
relationship type: By Homology

uniprot Q9C8T3 51
type: UnificationXref
id: Q9C8T3
db: uniprot

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q8VEE0 43
organism: Mus musculus

L-xylulose-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ascorbate degradation
type: Pathway
pathway component: STATE_TRANSITION_LEFT__ascorbate-_H2O-RIGHT__3_ketogulonate-_r1
pathway component: STATE_TRANSITION_LEFT__ATP-_3_ketogulonate-RIGHT__ADP-_3_ketogulonate_6_phosphate-_r2
pathway component: STATE_TRANSITION_LEFT__L_xylulose_5_phosphate-RIGHT__ribulose_5_phosphate-_r4
pathway component: STATE_TRANSITION_LEFT__ribulose_5_phosphate-RIGHT__D_xylulose_5_phosphate-_r5
pathway component: STATE_TRANSITION_LEFT__3_ketogulonate_6_phosphate-RIGHT__L_xylulose_5_phosphate-_CO2-_r3
xref: PANTHER Pathway P02729 1
comment: MODEL_NOTES=The prokaryotic degradation of ascorbate to xylulose-5-phosphate. Xylulose-5-phosphate is an intermediate in the Pentose phosphate pathway important for generating NADPH and pentose sugars for nucleotide biosynthesis. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 40

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__3_ketogulonate_6_phosphate-RIGHT__L_xylulose_5_phosphate-_CO2-_r3
controller: 3-keto-L-gulonate-6-phosphate decarboxylase

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 55

uniprot A0A1D5R167 12
type: UnificationXref
id: A0A1D5R167
db: uniprot

P02851
type: UnificationXref
id: P02851
db: PANTHER Pathway Component

P02852
type: UnificationXref
id: P02852
db: PANTHER Pathway Component

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 50

uniprot Q9X243 57
type: UnificationXref
id: Q9X243
db: uniprot

ncbitaxon 190304 42
type: UnificationXref
id: 190304
db: ncbitaxon

STATE_TRANSITION_LEFT__ascorbate-_H2O-RIGHT__3_ketogulonate-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 69
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 70
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 68
left: H2O
left: ascorbate
interaction type: STATE_TRANSITION
right: 3-ketogulonate

uniprot Q95ZW2 47
type: UnificationXref
id: Q95ZW2
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 46

ncbitaxon 251221 34
type: UnificationXref
id: 251221
db: ncbitaxon

ncbitaxon 7955 32
type: UnificationXref
id: 7955
db: ncbitaxon

ncbitaxon 10090 44
type: UnificationXref
id: 10090
db: ncbitaxon

ascorbate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__L_xylulose_5_phosphate-RIGHT__ribulose_5_phosphate-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 74
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 73
left: L-xylulose-5-phosphate
interaction type: STATE_TRANSITION
right: ribulose-5-phosphate

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9544 13
type: UnificationXref
id: 9544
db: ncbitaxon

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 48

uniprot P94525 8
type: UnificationXref
id: P94525
db: uniprot

ncbitaxon 39947 60
type: UnificationXref
id: 39947
db: ncbitaxon

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot O34557 22
organism: Bacillus subtilis

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot A0A1D5R167 12
organism: Macaca mulatta

uniprot Q96AT9 49
type: UnificationXref
id: Q96AT9
db: uniprot

ncbitaxon 243090 36
type: UnificationXref
id: 243090
db: ncbitaxon

uniprot Q8F3K8 39
type: UnificationXref
id: Q8F3K8
db: uniprot

ncbitaxon 9615 17
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot P46969 29
type: UnificationXref
id: P46969
db: uniprot

Ribulose-phosphate 3-epimerase, chloroplastic
type: ProteinReference
xref: uniprot Q9ZTP5 59
organism: Oryza sativa

ncbitaxon 559292 30
type: UnificationXref
id: 559292
db: ncbitaxon

ncbitaxon 284812 21
type: UnificationXref
id: 284812
db: ncbitaxon

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q9X243 57
organism: Thermotoga maritima

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q9C8T3 51
organism: Arabidopsis thaliana

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot Q7NFH7 33
organism: Gloeobacter violaceus

uniprot Q9ZTP5 59
type: UnificationXref
id: Q9ZTP5
db: uniprot

Ribulose-phosphate 3-epimerase
type: ProteinReference
xref: uniprot O84123 25
organism: Chlamydia trachomatis

uniprot Q9SAU2 56
type: UnificationXref
id: Q9SAU2
db: uniprot

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 3

Danio rerio
type: BioSource
xref: ncbitaxon 7955 32

uniprot Q8VEE0 43
type: UnificationXref
id: Q8VEE0
db: uniprot

ncbitaxon 10116 11
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot A0A0G2JW38 10
type: UnificationXref
id: A0A0G2JW38
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot F7FDW3 18
type: UnificationXref
id: F7FDW3
db: uniprot

ncbitaxon 226186 38
type: UnificationXref
id: 226186
db: ncbitaxon

STATE_TRANSITION_LEFT__ribulose_5_phosphate-RIGHT__D_xylulose_5_phosphate-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 71
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 72
left: ribulose-5-phosphate
interaction type: STATE_TRANSITION
right: D-xylulose-5-phosphate

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 60

D-allulose-6-phosphate 3-epimerase
type: ProteinReference
xref: uniprot P32719 27
organism: Escherichia coli

uniprot Q7UX51 35
type: UnificationXref
id: Q7UX51
db: uniprot

L-ribulose-5-phosphate 4-epimerase UlaF
type: ProteinReference
xref: uniprot P39306 7
organism: Escherichia coli

ncbitaxon 6239 48
type: UnificationXref
id: 6239
db: ncbitaxon