ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r3 53
type: Stoichiometry
physical entity: aspartate
stoichiometric coefficient: 1.0

uniprot P08243 15
type: UnificationXref
id: P08243
db: uniprot

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 48

PARTICIPANT STOICHIOMETRY r3 55
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

AMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 83332 32
type: UnificationXref
id: 83332
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r3 54
type: Stoichiometry
physical entity: NH3
stoichiometric coefficient: 1.0

ncbitaxon 9913 34
type: UnificationXref
id: 9913
db: ncbitaxon

Putative asparagine synthetase [glutamine-hydrolyzing] 2
type: ProteinReference
xref: uniprot Q58456 38
organism: Methanocaldococcus jannaschii

Protein CBR-ASNS-1
type: ProteinReference
xref: uniprot A8WQK1 2
organism: Caenorhabditis briggsae

uniprot P49089 25
type: UnificationXref
id: P49089
db: uniprot

uniprot P49088 23
type: UnificationXref
id: P49088
db: uniprot

uniprot P49078 21
type: UnificationXref
id: P49078
db: uniprot

ncbitaxon 224308 20
type: UnificationXref
id: 224308
db: ncbitaxon

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 44

Asparagine synthetase
type: ProteinReference
xref: uniprot Q21463 35
organism: Caenorhabditis elegans

uniprot A8XMA3 4
type: UnificationXref
id: A8XMA3
db: uniprot

ncbitaxon 100226 52
type: UnificationXref
id: 100226
db: ncbitaxon

STATE_TRANSITION_LEFT__aspartate-_NH3-_ATP-RIGHT__AMP-_PPi-_asparagine-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 58
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 57
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 55
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 54
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 56
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 53
left: aspartate
left: NH3
left: ATP
interaction type: STATE_TRANSITION
right: AMP
right: PPi
right: asparagine

ncbitaxon 36329 14
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot Q7QFU7 43
type: UnificationXref
id: Q7QFU7
db: uniprot

Asparagine synthetase
type: ProteinReference
xref: P02853
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Asparagine synthetase Synonym: Synonym not specified Accession: P02853
comment: ENTITY_REFERENCE_ID_DESC=Asparagine and aspartate biosynthesis.PROTEIN.GENERIC.Asparagine_br_synthetase
member entity reference: ASNS isoform 1
member entity reference: Asparagine synthetase [glutamine-hydrolyzing]
member entity reference: Asparagine synthetase [glutamine-hydrolyzing] 2
member entity reference: Asparagine synthetase (glutamine-hydrolyzing)
member entity reference: Putative asparagine synthetase [glutamine-hydrolyzing] 1
member entity reference: Asparagine synthetase
member entity reference: Asparagine synthetase [glutamine-hydrolyzing] 1
member entity reference: AGAP003833-PA
member entity reference: Asparagine synthetase B [glutamine-hydrolyzing]
member entity reference: Protein CBR-ASNS-2
member entity reference: Asparagine synthetase [glutamine-hydrolyzing] 3
member entity reference: Protein CBR-ASNS-1
member entity reference: Probable asparagine synthetase [glutamine-hydrolyzing]
member entity reference: Asparagine synthetase [glutamine-hydrolyzing],putative
member entity reference: Putative asparagine synthetase
member entity reference: Putative asparagine synthetase [glutamine-hydrolyzing]
member entity reference: Putative asparagine synthetase [glutamine-hydrolyzing] 2
member entity reference: Asparagine synthase (Glutamine-hydrolyzing)

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 20

Asparagine synthetase [glutamine-hydrolyzing] 1
type: ProteinReference
xref: uniprot P49078 21
organism: Arabidopsis thaliana

STATE_TRANSITION_LEFT__aspartate-_H2O-_ATP-_glutamine-RIGHT__AMP-_PPi-_glutamate-_asparagine-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 66
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 59
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 65
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 63
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 64
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 62
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 60
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 61
left: H2O
left: aspartate
left: ATP
left: glutamine
interaction type: STATE_TRANSITION
right: glutamate
right: AMP
right: PPi
right: asparagine

Bos taurus
type: BioSource
xref: ncbitaxon 9913 34

uniprot F6SSI3 7
type: UnificationXref
id: F6SSI3
db: uniprot

ncbitaxon 243232 39
type: UnificationXref
id: 243232
db: ncbitaxon

Protein CBR-ASNS-2
type: ProteinReference
xref: uniprot A8XMA3 4
organism: Caenorhabditis briggsae

oxaloacetate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 8

STATE_TRANSITION_LEFT__glutamate-_oxaloacetate-RIGHT__aspartate-_2_oxoglutarate-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 70
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 67
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 69
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 68
left: glutamate
left: oxaloacetate
interaction type: STATE_TRANSITION
right: aspartate
right: 2-oxoglutarate

uniprot E2RF46 5
type: UnificationXref
id: E2RF46
db: uniprot

uniprot Q58516 40
type: UnificationXref
id: Q58516
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 42

Asparagine synthetase (glutamine-hydrolyzing)
type: ProteinReference
xref: uniprot E2RF46 5
organism: Canis lupus familiaris

Asparagine synthetase [glutamine-hydrolyzing] 1
type: ProteinReference
xref: uniprot P54420 28
organism: Bacillus subtilis

uniprot Q1LZA3 33
type: UnificationXref
id: Q1LZA3
db: uniprot

ncbitaxon 64091 48
type: UnificationXref
id: 64091
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r3 58
type: Stoichiometry
physical entity: asparagine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 56
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 57
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

NH3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Asparagine synthetase
type: ProteinReference
xref: uniprot Q9HR47 47
organism: Halobacterium salinarum

ASNS isoform 1
type: ProteinReference
xref: uniprot H2QUZ4 9
organism: Pan troglodytes

ncbitaxon 559292 26
type: UnificationXref
id: 559292
db: ncbitaxon

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 26

PARTICIPANT STOICHIOMETRY r2 66
type: Stoichiometry
physical entity: asparagine
stoichiometric coefficient: 1.0

uniprot P9WN33 31
type: UnificationXref
id: P9WN33
db: uniprot

ncbitaxon 83333 18
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot Q9HR47 47
type: UnificationXref
id: Q9HR47
db: uniprot

Putative asparagine synthetase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P9WN33 31
organism: Mycobacterium tuberculosis

uniprot Q58456 38
type: UnificationXref
id: Q58456
db: uniprot

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 46

uniprot Q21463 35
type: UnificationXref
id: Q21463
db: uniprot

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Asparagine synthetase B [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P22106 17
organism: Escherichia coli

uniprot Q9LV77 50
type: UnificationXref
id: Q9LV77
db: uniprot

Aspartate aminotransferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q43011 36
type: UnificationXref
id: Q43011
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 24

uniprot Q61024 41
type: UnificationXref
id: Q61024
db: uniprot

PARTICIPANT STOICHIOMETRY r2 59
type: Stoichiometry
physical entity: aspartate
stoichiometric coefficient: 1.0

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 6

Asparagine synthetase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q61024 41
organism: Mus musculus

Asparagine synthetase [glutamine-hydrolyzing] 2
type: ProteinReference
xref: uniprot Q9LV77 50
organism: Arabidopsis thaliana

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 14

ncbitaxon 6239 12
type: UnificationXref
id: 6239
db: ncbitaxon

aspartate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Probable asparagine synthetase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P78753 29
organism: Schizosaccharomyces pombe

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r2 60
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 61
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Putative asparagine synthetase [glutamine-hydrolyzing] 1
type: ProteinReference
xref: uniprot Q58516 40
organism: Methanocaldococcus jannaschii

PARTICIPANT STOICHIOMETRY r2 62
type: Stoichiometry
physical entity: glutamine
stoichiometric coefficient: 1.0

asparagine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r2 63
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 64
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 65
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

Putative asparagine synthetase
type: ProteinReference
xref: uniprot Q9RJK2 51
organism: Streptomyces coelicolor

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P02853
type: UnificationXref
id: P02853
db: PANTHER Pathway Component

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 30

ncbitaxon 10116 24
type: UnificationXref
id: 10116
db: ncbitaxon

Asparagine synthetase [glutamine-hydrolyzing] 2
type: ProteinReference
xref: uniprot P42113 19
organism: Bacillus subtilis

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 52

PARTICIPANT STOICHIOMETRY r1 69
type: Stoichiometry
physical entity: aspartate
stoichiometric coefficient: 1.0

glutamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 3702 22
type: UnificationXref
id: 3702
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r1 68
type: Stoichiometry
physical entity: oxaloacetate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 67
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glutamate-_oxaloacetate-RIGHT__aspartate-_2_oxoglutarate-_r1
controller: Aspartate aminotransferase

PARTICIPANT STOICHIOMETRY r1 70
type: Stoichiometry
physical entity: 2-oxoglutarate
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__aspartate-_H2O-_ATP-_glutamine-RIGHT__AMP-_PPi-_glutamate-_asparagine-_r2
controller: Asparagine synthetase

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

Asparagine synthetase [glutamine-hydrolyzing] 2
type: ProteinReference
xref: uniprot Q43011 36
organism: Oryza sativa

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

uniprot P22106 17
type: UnificationXref
id: P22106
db: uniprot

Asparagine synthetase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot F6SSI3 7
organism: Macaca mulatta

uniprot Q9RJK2 51
type: UnificationXref
id: Q9RJK2
db: uniprot

ncbitaxon 9606 16
type: UnificationXref
id: 9606
db: ncbitaxon

ncbitaxon 6238 3
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot H2QUZ4 9
type: UnificationXref
id: H2QUZ4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__aspartate-_NH3-_ATP-RIGHT__AMP-_PPi-_asparagine-_r3
controller: Aspartate Asparagine-lyase

Asparagine and aspartate biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__glutamate-_oxaloacetate-RIGHT__aspartate-_2_oxoglutarate-_r1
pathway component: STATE_TRANSITION_LEFT__aspartate-_NH3-_ATP-RIGHT__AMP-_PPi-_asparagine-_r3
pathway component: STATE_TRANSITION_LEFT__aspartate-_H2O-_ATP-_glutamine-RIGHT__AMP-_PPi-_glutamate-_asparagine-_r2
xref: PANTHER Pathway P02730 1
comment: MODEL_NOTES=The biosynthesis of the amino acids aspartate and asparagine critical to protein biosynthesis. Website=www.biocyc.org/Ecoli/Pathways/ free text=Biochemistry (text) Voet and Voet

uniprot P54420 28
type: UnificationXref
id: P54420
db: uniprot

ncbitaxon 9615 6
type: UnificationXref
id: 9615
db: ncbitaxon

ncbitaxon 10090 42
type: UnificationXref
id: 10090
db: ncbitaxon

Asparagine synthase (Glutamine-hydrolyzing)
type: ProteinReference
xref: uniprot Q8TPE7 45
organism: Methanosarcina acetivorans

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 16

ncbitaxon 39947 37
type: UnificationXref
id: 39947
db: ncbitaxon

Aspartate Asparagine-lyase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Asparagine synthetase
type: ProteinReference
xref: uniprot O16924 11
organism: Caenorhabditis elegans

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 39

ncbitaxon 7165 44
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot Q8TPE7 45
type: UnificationXref
id: Q8TPE7
db: uniprot

uniprot P49090 27
type: UnificationXref
id: P49090
db: uniprot

Asparagine synthetase [glutamine-hydrolyzing] 1
type: ProteinReference
xref: uniprot P49089 25
organism: Saccharomyces cerevisiae

Asparagine synthetase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P49088 23
organism: Rattus norvegicus

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 22

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 3

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 12

PANTHER Pathway P02730 1
type: UnificationXref
id: P02730
db: PANTHER Pathway

ncbitaxon 188937 46
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot P42113 19
type: UnificationXref
id: P42113
db: uniprot

uniprot A8WQK1 2
type: UnificationXref
id: A8WQK1
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 32

Asparagine synthetase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P08243 15
organism: Homo sapiens

AGAP003833-PA
type: ProteinReference
xref: uniprot Q7QFU7 43
organism: Anopheles gambiae

Asparagine synthetase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q1LZA3 33
organism: Bos taurus

uniprot O16924 11
type: UnificationXref
id: O16924
db: uniprot

uniprot Q9LFU1 49
type: UnificationXref
id: Q9LFU1
db: uniprot

Asparagine synthetase
type: Protein
entity reference: Asparagine synthetase
comment: SPECIES_TYPE=PROTEIN

2-oxoglutarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 18

uniprot O77330 13
type: UnificationXref
id: O77330
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 37

ncbitaxon 284812 30
type: UnificationXref
id: 284812
db: ncbitaxon

Asparagine synthetase [glutamine-hydrolyzing],putative
type: ProteinReference
xref: uniprot O77330 13
organism: Plasmodium falciparum

Asparagine synthetase [glutamine-hydrolyzing] 2
type: ProteinReference
xref: uniprot P49090 27
organism: Saccharomyces cerevisiae

uniprot P78753 29
type: UnificationXref
id: P78753
db: uniprot

Asparagine synthetase [glutamine-hydrolyzing] 3
type: ProteinReference
xref: uniprot Q9LFU1 49
organism: Arabidopsis thaliana

ncbitaxon 9544 8
type: UnificationXref
id: 9544
db: ncbitaxon