Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P62999 169
xref: PTHR24072:SF105
organism: Canis lupus familiaris

uniprot C3YJC1 151
type: UnificationXref
id: C3YJC1
db: uniprot

Rac family small GTPase 3
type: ProteinReference
xref: uniprot F6THF0 159
xref: PTHR24072:SF301
organism: Monodelphis domestica

Netrin-G1
type: ProteinReference
xref: uniprot Q8R4G0 64
organism: Mus musculus

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot O08565 132
xref: PTHR10489:SF594
organism: Rattus norvegicus

Netrin-G2
type: ProteinReference
xref: uniprot F7EV15 51
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RCT0 19
organism: Monodelphis domestica

uniprot Q8CFN2 125
type: UnificationXref
id: Q8CFN2
db: uniprot

uniprot Q3LSL6 139
type: UnificationXref
id: Q3LSL6
db: uniprot

Y Mena s4 a4 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Mena s4 a4 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Ptp10D
type: ProteinReference
xref: P00343
standard name: Receptor-linked protein-tyrosine phosphatase 10D
comment: ENTITY_REFERENCE_NOTES=Long Name: Receptor-linked protein-tyrosine phosphatase 10D Synonym: Synonym not specified Accession: P00343
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.RECEPTOR.Ptp10D
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Tyrosine-protein phosphatase 10D

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YJC1 151
xref: PTHR24072:SF281
organism: Branchiostoma floridae

a59_degraded
type: PhysicalEntity
cellular location: endosome
comment: SPECIES_TYPE=DEGRADED

uniprot F6RCT0 19
type: UnificationXref
id: F6RCT0
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Complex__Netrin_DCC_-RIGHT__Complex__Netrin_DCC_-_re25
control type: INHIBITION
controller: Complex (Slit/Robo/ DCC)

Sdf1 s16 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Sdf1
stoichiometric coefficient: 1.0

Cxcr4
type: ProteinReference
xref: P00351
standard name: Chemokine, CXC motif, receptor4
comment: ENTITY_REFERENCE_NOTES=Long Name: Chemokine, CXC motif, receptor4 Synonym: CXC chemokine receptor 4,LAP3,LPS-associated protein 3,NPY3R,Neuropeptide Y receptor Y3 Accession: P00351
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.RECEPTOR.Cxcr4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: C-X-C chemokine receptor type 4
member entity reference: Uncharacterized protein
member entity reference: Chemokine (C-X-C motif) receptor 4a
member entity reference: Chemokine (C-X-C motif), receptor 4b

STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_re24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 272
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 273
left: Rho
interaction type: STATE_TRANSITION
right: Rho

PTHR45836:SF2
type: RelationshipXref
id: PTHR45836:SF2
db: PANTHER Family
relationship type: By Homology

uniprot A7S9Y5 190
type: UnificationXref
id: A7S9Y5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR44170:SF8
xref: uniprot F7F4D5 144
organism: Monodelphis domestica

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63001 171
xref: PTHR24072:SF105
organism: Mus musculus

uniprot B3RIM6 193
type: UnificationXref
id: B3RIM6
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63000 170
xref: PTHR24072:SF105
organism: Homo sapiens

ncbitaxon 9258 22
type: UnificationXref
id: 9258
db: ncbitaxon

ncbitaxon 7227 41
type: UnificationXref
id: 7227
db: ncbitaxon

PTHR45836:SF3
type: RelationshipXref
id: PTHR45836:SF3
db: PANTHER Family
relationship type: By Homology

uniprot P00519 85
type: UnificationXref
id: P00519
db: uniprot

Stromal cell-derived factor 1
type: ProteinReference
xref: uniprot Q5EBF6 81
organism: Xenopus tropicalis

HETERODIMER_ASSOCIATION_LEFT__Complex__Slit_Robo__SrGAP_-_DCC-RIGHT__Complex__Slit_Robo__DCC_-_SrGAP-_r25
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 284
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 283
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 282
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 285
left: DCC
left: Complex (Slit/Robo/ SrGAP)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Slit/Robo/ DCC)
right: SrGAP

Netrin s50 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Netrin
stoichiometric coefficient: 1.0

Mus musculus
type: BioSource
xref: ncbitaxon 10090 36

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60766 116
organism: Mus musculus

By Homology
type: RelationshipTypeVocabulary

uniprot Q63155 147
type: UnificationXref
id: Q63155
db: uniprot

uniprot F1MA79 12
type: UnificationXref
id: F1MA79
db: uniprot

Slit homolog 1 protein
type: ProteinReference
xref: PTHR45836:SF3
xref: uniprot Q80TR4 35
organism: Mus musculus

Predicted protein
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot A7S9Y5 190
organism: Nematostella vectensis

endosome
type: CellularLocationVocabulary
xref: GO GO:0005768 2

uniprot P06780 201
type: UnificationXref
id: P06780
db: uniprot

uniprot F6THF0 159
type: UnificationXref
id: F6THF0
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 202

Ras-related protein rac-2
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot Q94124 184
organism: Caenorhabditis elegans

Netrin 1
type: ProteinReference
xref: PTHR10574:SF378
xref: uniprot H2QC90 56
organism: Pan troglodytes

eco ECO:0000250 6
type: UnificationXref
id: ECO:0000250
db: eco

ncbitaxon 7955 9
type: UnificationXref
id: 7955
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r16 260
type: Stoichiometry
physical entity: Complex (Sdf1/Cxcr4)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10574:SF378
xref: uniprot F1N0C7 48
organism: Bos taurus

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 41

uniprot P60952 117
type: UnificationXref
id: P60952
db: uniprot

uniprot Q07FZ4 138
type: UnificationXref
id: Q07FZ4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF325
xref: uniprot F7GY91 161
organism: Macaca mulatta

uniprot F7ES59 197
type: UnificationXref
id: F7ES59
db: uniprot

Protein CBR-SAX-3
type: ProteinReference
xref: uniprot A8XJJ4 91
organism: Caenorhabditis briggsae

Roundabout guidance receptor 1
type: ProteinReference
xref: uniprot A0A3Q2U471 90
organism: Gallus gallus

PTHR10574:SF282
type: RelationshipXref
id: PTHR10574:SF282
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3S5ZPQ6 130
xref: PTHR10489:SF594
organism: Gallus gallus

uniprot P00520 86
type: UnificationXref
id: P00520
db: uniprot

ncbitaxon 9598 5
type: UnificationXref
id: 9598
db: ncbitaxon

ncbitaxon 284811 128
type: UnificationXref
id: 284811
db: ncbitaxon

uniprot Q9HE04 213
type: UnificationXref
id: Q9HE04
db: uniprot

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

Cell division cycle 42
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q28BZ0 123
organism: Xenopus tropicalis

Tyrosine-protein phosphatase 10D
type: ProteinReference
xref: PTHR19134:SF483
xref: uniprot P35992 40
organism: Drosophila melanogaster

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: uniprot P08134 203
xref: PTHR24072:SF100
organism: Homo sapiens

Netrin G1
type: ProteinReference
xref: uniprot A0A2I3SXZ1 43
organism: Pan troglodytes

DCC
type: Protein
entity reference: DCC
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Comm
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa11 240
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

DCC s51 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DCC
stoichiometric coefficient: 1.0

Netrin
type: Protein
entity reference: Netrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa8 220
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F6XSJ9 160
type: UnificationXref
id: F6XSJ9
db: uniprot

uniprot E1BP10 10
type: UnificationXref
id: E1BP10
db: uniprot

uniprot O94813 34
type: UnificationXref
id: O94813
db: uniprot

uniprot F6QGK3 96
type: UnificationXref
id: F6QGK3
db: uniprot

DCC
type: ProteinReference
xref: P00352
standard name: Deleted in colorectal carcinoma
comment: ENTITY_REFERENCE_NOTES=Long Name: Deleted in colorectal carcinoma Synonym: Synonym not specified Accession: P00352
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.RECEPTOR.DCC
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Uncharacterized protein
member entity reference: DCC netrin 1 receptor
member entity reference: Netrin receptor DCC

PARTICIPANT STOICHIOMETRY re26 265
type: Stoichiometry
physical entity: Comm
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 266
type: Stoichiometry
physical entity: Robo
stoichiometric coefficient: 1.0

eco ECO:0000270 66
type: UnificationXref
id: ECO:0000270
db: eco

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mena-RIGHT__Mena-_r3
controller: Abl

Cdc42
type: ProteinReference
xref: P00349
standard name: Cell division cycle 42
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cell division cycle 42 Synonym: G25K Accession: P00349
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.GENERIC.Cdc42
member entity reference: Cell division control protein 42 homolog isoform 2
member entity reference: Cell division control protein 42 homolog
member entity reference: Uncharacterized protein
member entity reference: Cell division control protein 42
member entity reference: Cdc42 homolog
member entity reference: Cdc42 protein, putative
member entity reference: Cell division cycle 42

PARTICIPANT STOICHIOMETRY re26 267
type: Stoichiometry
physical entity: Complex (Robo/Comm)
stoichiometric coefficient: 1.0

Axon guidance mediated by Slit/Robo
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Complex__Netrin_DCC_-RIGHT__Complex__Netrin_DCC_-_re25
pathway component: HETERODIMER_ASSOCIATION_LEFT__Comm-_Robo-RIGHT__Complex__Robo_Comm_-_re26
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r28
pathway component: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_re24
pathway component: TRANSPORT_LEFT__Complex__Robo_Comm_-RIGHT__Complex__Robo_Comm_-_r26
pathway component: HETERODIMER_ASSOCIATION_LEFT__DCC-_Slit-RIGHT__Complex__Slit_DCC_-_r21
pathway component: HETERODIMER_ASSOCIATION_LEFT__Slit-_SrGAP-_Robo-RIGHT__Complex__Slit_Robo__SrGAP_-_r18
pathway component: STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_re23
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Slit_Robo__SrGAP_-_DCC-RIGHT__Complex__Slit_Robo__DCC_-_SrGAP-_r25
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Cytoskeletal_dynamics-RIGHT__Axonal_plasticity-_r11
pathway component: STATE_TRANSITION_LEFT__Complex__Robo_Comm_-RIGHT__a59_degraded-_r27
pathway component: HETERODIMER_ASSOCIATION_LEFT__Cxcr4-_Sdf1-RIGHT__Complex__Sdf1_Cxcr4_-_r16
pathway component: STATE_TRANSITION_LEFT__Mena-RIGHT__Mena-_r3
pathway component: STATE_TRANSITION_LEFT__Abl-RIGHT__Abl-_r5
pathway component: STATE_TRANSITION_LEFT__Mena-RIGHT__Mena-_r4
xref: PANTHER Pathway P00008 1
comment: MODEL_NOTES=Panther Pathway: P00008 This pathway illustrates the intracellular signaling during neuronal axon growth guided by Slit through the Roundabout (Robo) transmembrane receptor. Medline=12677003 Medline=14682358 PMID: 12677003 PMID: 14682358

PARTICIPANT STOICHIOMETRY r16 258
type: Stoichiometry
physical entity: Cxcr4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 259
type: Stoichiometry
physical entity: Sdf1
stoichiometric coefficient: 1.0

Netrin-A
type: ProteinReference
xref: uniprot Q24567 62
organism: Drosophila melanogaster

Netrin-B
type: ProteinReference
xref: uniprot Q24568 63
organism: Drosophila melanogaster

Comm
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa16 236
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Complex__Netrin_DCC_-RIGHT__Complex__Netrin_DCC_-_re25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 271
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 270
left: Complex (Netrin/DCC)
interaction type: STATE_TRANSITION
right: Complex (Netrin/DCC)

uniprot Q8R4G0 64
type: UnificationXref
id: Q8R4G0
db: uniprot

Netrin
type: ProteinReference
xref: uniprot Q9NL28 70
organism: Ciona intestinalis

uniprot P48061 80
type: UnificationXref
id: P48061
db: uniprot

GTP-binding protein rho4
type: ProteinReference
xref: uniprot Q874R1 209
organism: Schizosaccharomyces pombe

uniprot Q5U1Y2 175
type: UnificationXref
id: Q5U1Y2
db: uniprot

uniprot F7CX22 23
type: UnificationXref
id: F7CX22
db: uniprot

Rac-like GTP-binding protein 6
type: ProteinReference
xref: uniprot Q6ZHA3 182
organism: Oryza sativa

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 5

Netrin receptor DCC
type: ProteinReference
xref: PTHR44170:SF8
xref: uniprot Q63155 147
organism: Rattus norvegicus

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 26

uniprot Q924Z9 65
type: UnificationXref
id: Q924Z9
db: uniprot

uniprot A0A2I3SXZ1 43
type: UnificationXref
id: A0A2I3SXZ1
db: uniprot

Robo
type: Protein
entity reference: Robo
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa10 238
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q1RMJ6 206
organism: Bos taurus

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q8CFN2 125
organism: Rattus norvegicus

uniprot F1QCB2 131
type: UnificationXref
id: F1QCB2
db: uniprot

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot P61072 134
xref: PTHR10489:SF594
organism: Pan troglodytes

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot P61073 135
xref: PTHR10489:SF594
organism: Homo sapiens

Slit homolog 1 protein
type: ProteinReference
xref: uniprot O88279 32
xref: PTHR45836:SF3
organism: Rattus norvegicus

Roundabout, axon guidance receptor, homolog 1 (Drosophila)
type: ProteinReference
xref: uniprot F1R2D2 95
organism: Danio rerio

Rac family small GTPase 3a
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot Q6DGB7 176
organism: Danio rerio

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: uniprot Q62159 208
xref: PTHR24072:SF100
organism: Mus musculus

HETERODIMER_ASSOCIATION_LEFT__Comm-_Robo-RIGHT__Complex__Robo_Comm_-_re26
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 267
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 266
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 265
left: Comm
left: Robo
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Robo/Comm)

DCC netrin 1 receptor
type: ProteinReference
xref: PTHR44170:SF8
xref: uniprot A0A2I3RV08 141
organism: Pan troglodytes

Netrin 2-like (Chicken)
type: ProteinReference
xref: uniprot G3V6X3 53
organism: Rattus norvegicus

Slit guidance ligand 1
type: ProteinReference
xref: uniprot E1BP10 10
xref: PTHR45836:SF3
organism: Bos taurus

uniprot O88279 32
type: UnificationXref
id: O88279
db: uniprot

Netrin
type: ProteinReference
xref: P00344
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.GENERIC.Netrin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Netrin-1a
member entity reference: Netrin 2-like (Chicken)
member entity reference: Netrin-3
member entity reference: Netrin-1
member entity reference: Netrin-G2
member entity reference: NTN3 isoform 1
member entity reference: Netrin-4
member entity reference: Uncharacterized protein
member entity reference: Netrin-G1
member entity reference: NTN4 protein
member entity reference: Netrin G1
member entity reference: Netrin 4
member entity reference: Netrin G2
member entity reference: Netrin
member entity reference: Netrin 3
member entity reference: Netrin-A
member entity reference: Netrin-B
member entity reference: Netrin 1

uniprot Q7ZSZ9 183
type: UnificationXref
id: Q7ZSZ9
db: uniprot

uniprot Q80TR4 35
type: UnificationXref
id: Q80TR4
db: uniprot

uniprot G5EBF1 100
type: UnificationXref
id: G5EBF1
db: uniprot

Cdc42
type: Protein
entity reference: Cdc42
feature: ACTIVE 87
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein CBR-RHO-1
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot A8XIF5 192
organism: Caenorhabditis briggsae

Slit
type: ProteinReference
xref: P00342
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.GENERIC.Slit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Slit Synonym: Synonym not specified Accession: P00342
member entity reference: SLIT2 isoform 4
member entity reference: Slit homolog 1 protein
member entity reference: Slit guidance ligand 3
member entity reference: Slit guidance ligand 1
member entity reference: Slit homolog 2 protein
member entity reference: Slit homolog 3 (Drosophila)
member entity reference: Uncharacterized protein
member entity reference: Slit homolog 2 (Drosophila)
member entity reference: Slit homolog 3 protein
member entity reference: Slit guidance ligand 2

uniprot P61072 134
type: UnificationXref
id: P61072
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M085 78
organism: Bos taurus

uniprot Q22038 207
type: UnificationXref
id: Q22038
db: uniprot

uniprot Q90694 126
type: UnificationXref
id: Q90694
db: uniprot

Protein enabled homolog
type: ProteinReference
xref: uniprot Q03173 77
organism: Mus musculus

Netrin receptor DCC
type: ProteinReference
xref: PTHR44170:SF8
xref: uniprot P43146 145
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_re24
control type: ACTIVATION
controller: Complex (Slit/Robo/ SrGAP)

Robo
type: ProteinReference
xref: P00348
standard name: Roundabout
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.RECEPTOR.Robo
comment: ENTITY_REFERENCE_NOTES=Long Name: Roundabout Synonym: Synonym not specified Accession: P00348
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Roundabout, axon guidance receptor, homolog 2 (Drosophila)
member entity reference: Roundabout guidance receptor 1
member entity reference: Roundabout, axon guidance receptor, homolog 1 (Drosophila)
member entity reference: LP22668p
member entity reference: Roundabout homolog 1
member entity reference: Roundabout, axon guidance receptor, homolog 3 (Drosophila)
member entity reference: Uncharacterized protein
member entity reference: Protein CBR-SAX-3
member entity reference: Protein sax-3

uniprot P25930 133
type: UnificationXref
id: P25930
db: uniprot

uniprot O95631 61
type: UnificationXref
id: O95631
db: uniprot

uniprot A0A3Q2U471 90
type: UnificationXref
id: A0A3Q2U471
db: uniprot

uniprot A4FV20 187
type: UnificationXref
id: A4FV20
db: uniprot

plasma membrane
type: CellularLocationVocabulary
xref: GO GO:0005886 3

GO GO:0005768 2
type: UnificationXref
id: GO:0005768
db: GO

Cxcr4
type: Protein
entity reference: Cxcr4
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR10574:SF378
type: RelationshipXref
id: PTHR10574:SF378
db: PANTHER Family
relationship type: By Homology

Complex (Robo/Comm)
type: Complex
component stoichiometry: Comm s54 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Robo s55 sa10 STOICHIOMETRY ID COMPLEX
component: Robo
component: Comm
feature: COMPLEX BINDING FEATURE s52 a46 237
feature: COMPLEX BINDING FEATURE s52 a46 239
cellular location: plasma membrane

uniprot C4M8K6 155
type: UnificationXref
id: C4M8K6
db: uniprot

Slit homolog 3 protein
type: ProteinReference
xref: uniprot O75094 31
organism: Homo sapiens

Netrin-1a
type: ProteinReference
xref: uniprot O42140 60
xref: PTHR10574:SF378
organism: Danio rerio

Slit homolog 1 protein
type: ProteinReference
xref: uniprot O75093 29
xref: PTHR45836:SF3
organism: Homo sapiens

uniprot O89026 102
type: UnificationXref
id: O89026
db: uniprot

PARTICIPANT STOICHIOMETRY r27 278
type: Stoichiometry
physical entity: Complex (Robo/Comm)
stoichiometric coefficient: 1.0

Rho-related protein racA
type: ProteinReference
xref: uniprot P34147 165
organism: Dictyostelium discoideum

PARTICIPANT STOICHIOMETRY r27 279
type: Stoichiometry
physical entity: a59_degraded
stoichiometric coefficient: 1.0

Rho-related protein racB
type: ProteinReference
xref: uniprot P34148 166
organism: Dictyostelium discoideum

uniprot Q96CW9 67
type: UnificationXref
id: Q96CW9
db: uniprot

Rho-related protein rac1B
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34145 163
organism: Dictyostelium discoideum

uniprot P79394 137
type: UnificationXref
id: P79394
db: uniprot

uniprot F6WEP3 21
type: UnificationXref
id: F6WEP3
db: uniprot

Rho
type: Protein
entity reference: Rho
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Ras homolog family member C
type: ProteinReference
xref: uniprot A0A2I3S4I6 186
xref: PTHR24072:SF100
organism: Pan troglodytes

ncbitaxon 13616 20
type: UnificationXref
id: 13616
db: ncbitaxon

Roundabout, axon guidance receptor, homolog 3 (Drosophila)
type: ProteinReference
xref: uniprot A0A2R8QRK0 89
organism: Danio rerio

Comm s34 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Comm
stoichiometric coefficient: 1.0

Slit homolog 3 protein
type: ProteinReference
xref: uniprot Q9WVB4 39
organism: Mus musculus

uniprot P40792 167
type: UnificationXref
id: P40792
db: uniprot

uniprot Q9HF54 214
type: UnificationXref
id: Q9HF54
db: uniprot

uniprot F7DQ42 25
type: UnificationXref
id: F7DQ42
db: uniprot

uniprot P61073 135
type: UnificationXref
id: P61073
db: uniprot

uniprot Q6RUV5 181
type: UnificationXref
id: Q6RUV5
db: uniprot

uniprot P34147 165
type: UnificationXref
id: P34147
db: uniprot

Rho-related GTP-binding protein RhoJ
type: ProteinReference
xref: PTHR24072:SF17
xref: uniprot Q9ER71 212
organism: Mus musculus

GTP-binding protein RHO1
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot O42825 199
organism: Candida albicans

uniprot Q1RMJ6 206
type: UnificationXref
id: Q1RMJ6
db: uniprot

Slit guidance ligand 2
type: ProteinReference
xref: PTHR45836:SF2
xref: uniprot F6WEP3 21
organism: Ornithorhynchus anatinus

NTN4 protein
type: ProteinReference
xref: PTHR10574:SF282
xref: uniprot A7MB18 46
organism: Bos taurus

uniprot Q6EP31 177
type: UnificationXref
id: Q6EP31
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 11

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Complex (Slit/DCC)

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 24

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot Q05144 172
type: UnificationXref
id: Q05144
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 22

ncbitaxon 6238 92
type: UnificationXref
id: 6238
db: ncbitaxon

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q9TU25 185
xref: PTHR24072:SF169
organism: Bos taurus

uniprot Q6GL60 179
type: UnificationXref
id: Q6GL60
db: uniprot

uniprot F6WF30 97
type: UnificationXref
id: F6WF30
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Complex (Netrin/DCC)

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 150

ncbitaxon 284812 120
type: UnificationXref
id: 284812
db: ncbitaxon

Ras-like GTP-binding protein Rho1
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot P48148 204
organism: Drosophila melanogaster

Rac-like GTP-binding protein 5
type: ProteinReference
xref: uniprot Q6EP31 177
organism: Oryza sativa

DCC netrin 1 receptor
type: ProteinReference
xref: PTHR44170:SF8
xref: uniprot F1PAZ4 142
organism: Canis lupus familiaris

Uncharacterized protein racE
type: ProteinReference
xref: uniprot F0ZMZ8 156
organism: Dictyostelium purpureum

uniprot K7C5Y1 57
type: UnificationXref
id: K7C5Y1
db: uniprot

uniprot F7A403 49
type: UnificationXref
id: F7A403
db: uniprot

Comm
type: Protein
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9NL28 70
type: UnificationXref
id: Q9NL28
db: uniprot

uniprot A0A3Q1LI98 83
type: UnificationXref
id: A0A3Q1LI98
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mena-RIGHT__Mena-_r4
controller: Ptp10D

uniprot F7GY91 161
type: UnificationXref
id: F7GY91
db: uniprot

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot P70658 136
xref: PTHR10489:SF594
organism: Mus musculus

Slit homolog 2 protein
type: ProteinReference
xref: uniprot F1MA79 12
xref: PTHR45836:SF2
organism: Rattus norvegicus

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 106

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Rho

Cell division control protein 42 homolog isoform 2
type: ProteinReference
xref: uniprot F6RBZ7 111
xref: PTHR24072:SF337
organism: Macaca mulatta

uniprot A0A2I3SC33 88
type: UnificationXref
id: A0A2I3SC33
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60952 117
organism: Canis lupus familiaris

Netrin 1
type: ProteinReference
xref: PTHR10574:SF378
xref: uniprot F7G4D6 52
organism: Monodelphis domestica

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60953 118
organism: Homo sapiens

uniprot Q7Z6B7 129
type: UnificationXref
id: Q7Z6B7
db: uniprot

SrGAP
type: Protein
entity reference: SrGAP
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P48148 204
type: UnificationXref
id: P48148
db: uniprot

uniprot E9HL06 195
type: UnificationXref
id: E9HL06
db: uniprot

uniprot A7EEX6 188
type: UnificationXref
id: A7EEX6
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 16

Roundabout guidance receptor 1
type: ProteinReference
xref: uniprot F6WF30 97
organism: Xenopus tropicalis

GTPase cRac1A
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6LC82 180
organism: Gallus gallus

Robo s55 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Robo
stoichiometric coefficient: 1.0

uniprot Q9HB63 68
type: UnificationXref
id: Q9HB63
db: uniprot

Roundabout homolog 1
type: ProteinReference
xref: uniprot O89026 102
organism: Mus musculus

Rho family GTPase
type: ProteinReference
xref: uniprot C4M8K6 155
xref: PTHR24072:SF281
organism: Entamoeba histolytica

uniprot F7F4D5 144
type: UnificationXref
id: F7F4D5
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 76

Slit
type: Protein
entity reference: Slit
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa3 242
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Slit
type: Protein
entity reference: Slit
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 248
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9HF56 127
type: UnificationXref
id: Q9HF56
db: uniprot

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot Q07FZ4 138
xref: PTHR10489:SF594
organism: Xenopus tropicalis

Slit s12 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Slit
stoichiometric coefficient: 1.0

uniprot A0A2I3S7G9 82
type: UnificationXref
id: A0A2I3S7G9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot E9HL06 195
organism: Daphnia pulex

uniprot F0ZMZ8 156
type: UnificationXref
id: F0ZMZ8
db: uniprot

uniprot Q03173 77
type: UnificationXref
id: Q03173
db: uniprot

Netrin 1
type: ProteinReference
xref: uniprot F7CBX5 50
xref: PTHR10574:SF378
organism: Xenopus tropicalis

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot Q01112 119
organism: Schizosaccharomyces pombe

Rac family small GTPase 1a
type: ProteinReference
xref: uniprot Q7ZSZ9 183
xref: PTHR24072:SF105
organism: Danio rerio

Stromal cell-derived factor 1
type: ProteinReference
xref: uniprot P48061 80
organism: Homo sapiens

Y Mena s22 a25 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Mena s22 a25 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR24418:SF162
type: RelationshipXref
id: PTHR24418:SF162
db: PANTHER Family
relationship type: By Homology

PANTHER Pathway P00008 1
type: UnificationXref
id: P00008
db: PANTHER Pathway

Complex (Slit/Robo/ SrGAP)
type: Complex
component stoichiometry: SrGAP s15 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Slit s12 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Robo s13 sa4 STOICHIOMETRY ID COMPLEX
component: SrGAP
component: Slit
component: Robo
feature: ACTIVE 87
feature: COMPLEX BINDING FEATURE s19 a22 243
feature: COMPLEX BINDING FEATURE s19 a22 241
feature: COMPLEX BINDING FEATURE s19 a22 245
cellular location: plasma membrane

PARTICIPANT STOICHIOMETRY r26 280
type: Stoichiometry
physical entity: Complex (Robo/Comm)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 281
type: Stoichiometry
physical entity: Complex (Robo/Comm)
stoichiometric coefficient: 1.0

uniprot G7MIC2 54
type: UnificationXref
id: G7MIC2
db: uniprot

STATE_TRANSITION_LEFT__Abl-RIGHT__Abl-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 262
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 261
left: Abl
interaction type: STATE_TRANSITION
right: Abl

STATE_TRANSITION
type: RelationshipTypeVocabulary

SrGAP
type: ProteinReference
xref: P00350
standard name: Slit-Robo GTPase activating protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.GENERIC.SrGAP
comment: ENTITY_REFERENCE_NOTES=Long Name: Slit-Robo GTPase activating protein Synonym: Synonym not specified Accession: P00350
member entity reference: SLIT-ROBO Rho GTPase-activating protein 1

SrGAP s15 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SrGAP
stoichiometric coefficient: 1.0

uniprot F1PYF1 196
type: UnificationXref
id: F1PYF1
db: uniprot

Slit
type: Protein
entity reference: Slit
comment: SPECIES_TYPE=PROTEIN

Rac
type: ProteinReference
xref: P00354
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.GENERIC.Rac
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras-related C3 botulinum toxin substrate Synonym: Synonym not specified Accession: P00354
member entity reference: Ras-related protein Rac2
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Uncharacterized protein racE
member entity reference: Uncharacterized protein
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Rac-like GTP-binding protein 5
member entity reference: Rac family small GTPase 3b
member entity reference: Rho-related protein racA
member entity reference: Rho-related protein racE
member entity reference: Rac family small GTPase 2
member entity reference: GTPase cRac1A
member entity reference: Rho family GTPase
member entity reference: Rac family small GTPase 1
member entity reference: Rac family small GTPase 1b
member entity reference: Uncharacterized protein rac1A
member entity reference: Rac family small GTPase 1a
member entity reference: Rac family small GTPase 3a
member entity reference: Ras-related protein rac-2
member entity reference: Rac family small GTPase 3
member entity reference: Rho-related protein rac1B
member entity reference: Ras-related protein Rac1
member entity reference: Rac-like GTP-binding protein 6
member entity reference: Rho-related protein racB
member entity reference: Rop-family small GTPase

Netrin-3
type: ProteinReference
xref: uniprot O00634 58
organism: Homo sapiens

GTP-binding protein rhoA
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot Q9C3Y4 210
organism: Emericella nidulans

uniprot A0A2R8RXU4 8
type: UnificationXref
id: A0A2R8RXU4
db: uniprot

uniprot P34145 163
type: UnificationXref
id: P34145
db: uniprot

uniprot A0A3S5ZPV2 75
type: UnificationXref
id: A0A3S5ZPV2
db: uniprot

LP22668p
type: ProteinReference
xref: uniprot Q9VPZ7 103
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_re23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 274
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 275
left: Cdc42
interaction type: STATE_TRANSITION
right: Cdc42

Slit guidance ligand 2
type: ProteinReference
xref: PTHR45836:SF2
xref: uniprot F1MLJ7 14
organism: Bos taurus

HETERODIMER_ASSOCIATION_LEFT__Cxcr4-_Sdf1-RIGHT__Complex__Sdf1_Cxcr4_-_r16
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 259
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 260
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 258
left: Sdf1
left: Cxcr4
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Sdf1/Cxcr4)

Ptp10D
type: Protein
entity reference: Ptp10D
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Roundabout homolog 1
type: ProteinReference
xref: uniprot Q9Y6N7 104
organism: Homo sapiens

Rho
type: ProteinReference
xref: P00355
standard name: Ras homologue gene family, member A
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.GENERIC.Rho
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras homologue gene family, member A Synonym: ARH,Aplysia ras-related homolog Accession: P00355
member entity reference: GTP-binding protein rhoA
member entity reference: Rho-related GTP-binding protein RhoC
member entity reference: Predicted protein
member entity reference: Ras homolog family member J
member entity reference: RHOJ protein
member entity reference: GTP-binding protein RHO1
member entity reference: GTP-binding protein rho4
member entity reference: Uncharacterized protein
member entity reference: RhoA protein
member entity reference: Rho-related GTP-binding protein RhoJ
member entity reference: Ras homolog family member C
member entity reference: GTP-binding protein rho5
member entity reference: Ras homolog family member B
member entity reference: GTP-binding protein
member entity reference: Ras-like GTP-binding protein Rho1
member entity reference: GTP-binding protein rho1
member entity reference: Protein CBR-RHO-1
member entity reference: Ras-like GTP-binding protein rhoA

Stromal cell-derived factor 1
type: ProteinReference
xref: uniprot P40224 79
organism: Mus musculus

uniprot O88280 33
type: UnificationXref
id: O88280
db: uniprot

ncbitaxon 237561 114
type: UnificationXref
id: 237561
db: ncbitaxon

Cxcr4 s17 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cxcr4
stoichiometric coefficient: 1.0

uniprot F6RRI0 143
type: UnificationXref
id: F6RRI0
db: uniprot

Netrin-1
type: ProteinReference
xref: uniprot Q924Z9 65
xref: PTHR10574:SF378
organism: Rattus norvegicus

uniprot G3V6X3 53
type: UnificationXref
id: G3V6X3
db: uniprot

Sdf1
type: Protein
entity reference: Sdf1
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa6 216
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR19134:SF483
type: RelationshipXref
id: PTHR19134:SF483
db: PANTHER Family
relationship type: By Homology

Ras-related protein Rac1
type: ProteinReference
xref: uniprot P40792 167
xref: PTHR24072:SF281
organism: Drosophila melanogaster

Cdc42 homolog
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot P40793 115
organism: Drosophila melanogaster

uniprot P60953 118
type: UnificationXref
id: P60953
db: uniprot

Complex (Netrin/DCC)
type: Complex
component stoichiometry: Netrin s50 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: DCC s51 sa9 STOICHIOMETRY ID COMPLEX
component: Netrin
component: DCC
feature: ACTIVE 87
feature: COMPLEX BINDING FEATURE s36 a41 219
feature: COMPLEX BINDING FEATURE s36 a41 221
cellular location: plasma membrane

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6RUV5 181
organism: Rattus norvegicus

uniprot Q874R1 209
type: UnificationXref
id: Q874R1
db: uniprot

RHOJ protein
type: ProteinReference
xref: uniprot A4FV20 187
xref: PTHR24072:SF17
organism: Bos taurus

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot P15153 162
organism: Homo sapiens

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 92

Slit guidance ligand 1
type: ProteinReference
xref: uniprot F1PSS7 15
xref: PTHR45836:SF3
organism: Canis lupus familiaris

uniprot F1QBD4 94
type: UnificationXref
id: F1QBD4
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 101

ncbitaxon 7739 108
type: UnificationXref
id: 7739
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re25 271
type: Stoichiometry
physical entity: Complex (Netrin/DCC)
stoichiometric coefficient: 1.0

Axonal plasticity
type: Pathway

PARTICIPANT STOICHIOMETRY re25 270
type: Stoichiometry
physical entity: Complex (Netrin/DCC)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GYE9 109
xref: PTHR24072:SF192
organism: Daphnia pulex

Complex (Slit/DCC)
type: Complex
component stoichiometry: DCC s11 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Slit s1 sa1 STOICHIOMETRY ID COMPLEX
component: Slit
component: DCC
feature: ACTIVE 87
feature: COMPLEX BINDING FEATURE s14 a14 247
feature: COMPLEX BINDING FEATURE s14 a14 249
cellular location: plasma membrane

Robo
type: Protein
entity reference: Robo
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Robo s13 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Robo
stoichiometric coefficient: 1.0

uniprot Q9VPZ7 103
type: UnificationXref
id: Q9VPZ7
db: uniprot

uniprot F1RCV3 18
type: UnificationXref
id: F1RCV3
db: uniprot

ncbitaxon 6669 110
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot O93468 200
type: UnificationXref
id: O93468
db: uniprot

Netrin-1
type: ProteinReference
xref: PTHR10574:SF378
xref: uniprot O95631 61
organism: Homo sapiens

Complex (Netrin/DCC)
type: Complex
component stoichiometry: DCC s51 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: Netrin s50 sa39 STOICHIOMETRY ID COMPLEX
component: DCC
component: Netrin
feature: COMPLEX BINDING FEATURE s36 csa8 223
feature: COMPLEX BINDING FEATURE s36 csa8 225
cellular location: plasma membrane

Slit homolog 2 (Drosophila)
type: ProteinReference
xref: uniprot A0A2R8RXU4 8
organism: Danio rerio

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 178

Cytoskeletal dynamics
type: Pathway

ncbitaxon 559292 202
type: UnificationXref
id: 559292
db: ncbitaxon

GO GO:0005886 3
type: UnificationXref
id: GO:0005886
db: GO

Rac family small GTPase 1b
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q29RC5 174
organism: Danio rerio

uniprot Q01112 119
type: UnificationXref
id: Q01112
db: uniprot

Netrin-G2
type: ProteinReference
xref: uniprot Q96CW9 67
organism: Homo sapiens

Netrin receptor DCC
type: ProteinReference
xref: uniprot P70211 146
xref: PTHR44170:SF8
organism: Mus musculus

GTP-binding protein
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot O93468 200
organism: Gallus gallus

Ras-like GTP-binding protein rhoA
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot Q22038 207
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r28 277
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Slit-_SrGAP-_Robo-RIGHT__Complex__Slit_Robo__SrGAP_-_r18
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 257
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 254
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 255
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 256
left: Robo
left: Slit
left: SrGAP
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Slit/Robo/ SrGAP)

PARTICIPANT STOICHIOMETRY r28 276
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

uniprot C3ZIB9 107
type: UnificationXref
id: C3ZIB9
db: uniprot

DCC
type: Protein
entity reference: DCC
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa14 232
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RRI0 143
xref: PTHR44170:SF8
organism: Macaca mulatta

Netrin-1
type: ProteinReference
xref: PTHR10574:SF378
xref: uniprot O09118 59
organism: Mus musculus

uniprot O00634 58
type: UnificationXref
id: O00634
db: uniprot

Mena
type: Protein
entity reference: Mena
feature: Y Mena s22 a25 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2R8QRK0 89
type: UnificationXref
id: A0A2R8QRK0
db: uniprot

Abl
type: Protein
entity reference: Abl
feature: ACTIVE 87
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

TRANSPORT
type: RelationshipTypeVocabulary

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Complex (Sdf1/Cxcr4)

Slit s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Slit
stoichiometric coefficient: 1.0

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 122

PARTICIPANT STOICHIOMETRY r18 254
type: Stoichiometry
physical entity: Slit
stoichiometric coefficient: 1.0

uniprot Q23862 173
type: UnificationXref
id: Q23862
db: uniprot

PARTICIPANT STOICHIOMETRY r18 255
type: Stoichiometry
physical entity: SrGAP
stoichiometric coefficient: 1.0

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 189

PARTICIPANT STOICHIOMETRY r18 256
type: Stoichiometry
physical entity: Robo
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 257
type: Stoichiometry
physical entity: Complex (Slit/Robo/ SrGAP)
stoichiometric coefficient: 1.0

uniprot E2R3Q6 47
type: UnificationXref
id: E2R3Q6
db: uniprot

Cell division cycle 42
type: ProteinReference
xref: uniprot Q52WY2 124
xref: PTHR24072:SF337
organism: Danio rerio

uniprot C4M5Z7 154
type: UnificationXref
id: C4M5Z7
db: uniprot

uniprot O42825 199
type: UnificationXref
id: O42825
db: uniprot

PTHR24072:SF337
type: RelationshipXref
id: PTHR24072:SF337
db: PANTHER Family
relationship type: By Homology

uniprot O75093 29
type: UnificationXref
id: O75093
db: uniprot

ncbitaxon 45351 191
type: UnificationXref
id: 45351
db: ncbitaxon

uniprot Q52WY2 124
type: UnificationXref
id: Q52WY2
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 108

ACTIVE 87
type: EntityFeature
comment: Active state

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 87
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7CBX5 50
type: UnificationXref
id: F7CBX5
db: uniprot

Tyrosine-protein kinase ABL1
type: ProteinReference
xref: uniprot P00520 86
xref: PTHR24418:SF162
organism: Mus musculus

Robo
type: Protein
entity reference: Robo
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa4 244
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot Q9R1B9 38
type: UnificationXref
id: Q9R1B9
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot E9PT20 84
xref: PTHR24418:SF162
organism: Rattus norvegicus

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 194

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 153

uniprot Q29RC5 174
type: UnificationXref
id: Q29RC5
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 6

Slit homolog 3 (Drosophila)
type: ProteinReference
xref: uniprot F1RCV3 18
organism: Danio rerio

ncbitaxon 665079 189
type: UnificationXref
id: 665079
db: ncbitaxon

HETERODIMER_ASSOCIATION_LEFT__DCC-_Slit-RIGHT__Complex__Slit_DCC_-_r21
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 253
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 252
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 251
left: DCC
left: Slit
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Slit/DCC)

uniprot Q9C3Y4 210
type: UnificationXref
id: Q9C3Y4
db: uniprot

uniprot Q6DGB7 176
type: UnificationXref
id: Q6DGB7
db: uniprot

PTHR24072:SF325
type: RelationshipXref
id: PTHR24072:SF325
db: PANTHER Family
relationship type: By Homology

Ras homolog family member B
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot F7FR08 198
organism: Ornithorhynchus anatinus

Tyrosine-protein kinase ABL1
type: ProteinReference
xref: uniprot P00519 85
organism: Homo sapiens

uniprot F7C6B8 98
type: UnificationXref
id: F7C6B8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N739 93
organism: Bos taurus

ncbitaxon 7165 122
type: UnificationXref
id: 7165
db: ncbitaxon

ncbitaxon 8364 26
type: UnificationXref
id: 8364
db: ncbitaxon

Rac
type: Protein
entity reference: Rac
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Cdc42-RIGHT__Cdc42-_re23
control type: ACTIVATION
controller: Complex (Slit/Robo/ SrGAP)

uniprot A7MB18 46
type: UnificationXref
id: A7MB18
db: uniprot

PARTICIPANT STOICHIOMETRY r3 268
type: Stoichiometry
physical entity: Mena
stoichiometric coefficient: 1.0

GTP-binding protein rho5
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot Q9HE04 213
organism: Schizosaccharomyces pombe

STATE_TRANSITION_LEFT__Complex__Robo_Comm_-RIGHT__a59_degraded-_r27
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 278
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 279
left: Complex (Robo/Comm)
interaction type: STATE_TRANSITION
right: a59_degraded

Rac family small GTPase 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q5U1Y2 175
organism: Rattus norvegicus

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 20

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot Q24568 63
type: UnificationXref
id: Q24568
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ES59 197
xref: PTHR24072:SF100
organism: Monodelphis domestica

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q90694 126
organism: Gallus gallus

ncbitaxon 39947 178
type: UnificationXref
id: 39947
db: ncbitaxon

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 71

PARTICIPANT STOICHIOMETRY r3 269
type: Stoichiometry
physical entity: Mena
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Mena-RIGHT__Mena-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 268
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 269
left: Mena
interaction type: STATE_TRANSITION
right: Mena

GTP-binding protein RHO1
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot Q9HF54 214
organism: Ashbya gossypii

uniprot H2QRZ2 28
type: UnificationXref
id: H2QRZ2
db: uniprot

STATE_TRANSITION_LEFT__Mena-RIGHT__Mena-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 264
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 263
left: Mena
interaction type: STATE_TRANSITION
right: Mena

uniprot P48554 168
type: UnificationXref
id: P48554
db: uniprot

ncbitaxon 7719 71
type: UnificationXref
id: 7719
db: ncbitaxon

ncbitaxon 227321 211
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q9Y2I2 73
type: UnificationXref
id: Q9Y2I2
db: uniprot

uniprot A0A0G2K6I4 74
type: UnificationXref
id: A0A0G2K6I4
db: uniprot

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 66

uniprot H2QC90 56
type: UnificationXref
id: H2QC90
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 120

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 128

Comm s54 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Comm
stoichiometric coefficient: 1.0

uniprot A9TLC7 149
type: UnificationXref
id: A9TLC7
db: uniprot

uniprot F6RBZ7 111
type: UnificationXref
id: F6RBZ7
db: uniprot

uniprot F7EV15 51
type: UnificationXref
id: F7EV15
db: uniprot

Cell division control protein 42
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot Q9HF56 127
organism: Ashbya gossypii

uniprot O42140 60
type: UnificationXref
id: O42140
db: uniprot

PTHR24072:SF281
type: RelationshipXref
id: PTHR24072:SF281
db: PANTHER Family
relationship type: By Homology

uniprot Q9ER71 212
type: UnificationXref
id: Q9ER71
db: uniprot

ncbitaxon 44689 164
type: UnificationXref
id: 44689
db: ncbitaxon

Roundabout, axon guidance receptor, homolog 2 (Drosophila)
type: ProteinReference
xref: uniprot F1QBD4 94
organism: Danio rerio

ncbitaxon 9031 76
type: UnificationXref
id: 9031
db: ncbitaxon

Slit guidance ligand 3
type: ProteinReference
xref: uniprot F1Q3G2 17
organism: Canis lupus familiaris

Ras homolog family member J
type: ProteinReference
xref: PTHR24072:SF17
xref: uniprot F1PYF1 196
organism: Canis lupus familiaris

ncbitaxon 6945 106
type: UnificationXref
id: 6945
db: ncbitaxon

Netrin-4
type: ProteinReference
xref: PTHR10574:SF282
xref: uniprot Q9HB63 68
organism: Homo sapiens

PTHR10489:SF594
type: RelationshipXref
id: PTHR10489:SF594
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Rac

Netrin-3
type: ProteinReference
xref: uniprot Q9R1A3 72
organism: Mus musculus

Netrin
type: Protein
entity reference: Netrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa39 224
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

SLIT-ROBO Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q7Z6B7 129
organism: Homo sapiens

Netrin 3
type: ProteinReference
xref: uniprot E2R3Q6 47
organism: Canis lupus familiaris

PTHR24072:SF192
type: RelationshipXref
id: PTHR24072:SF192
db: PANTHER Family
relationship type: By Homology

uniprot A9JRY8 148
type: UnificationXref
id: A9JRY8
db: uniprot

uniprot C4M5T0 152
type: UnificationXref
id: C4M5T0
db: uniprot

uniprot Q9PTF7 140
type: UnificationXref
id: Q9PTF7
db: uniprot

uniprot A8XIF5 192
type: UnificationXref
id: A8XIF5
db: uniprot

ncbitaxon 10116 13
type: UnificationXref
id: 10116
db: ncbitaxon

Complex (Slit/Robo/ DCC)
type: Complex
component stoichiometry: Robo s30 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: Slit s28 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: DCC s32 sa14 STOICHIOMETRY ID COMPLEX
component: Robo
component: DCC
component: Slit
feature: COMPLEX BINDING FEATURE s45 a58 227
feature: COMPLEX BINDING FEATURE s45 a58 229
feature: COMPLEX BINDING FEATURE s45 a58 231
cellular location: plasma membrane

PARTICIPANT STOICHIOMETRY r4 264
type: Stoichiometry
physical entity: Mena
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 263
type: Stoichiometry
physical entity: Mena
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot F6XSJ9 160
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r21 251
type: Stoichiometry
physical entity: DCC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 252
type: Stoichiometry
physical entity: Slit
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 253
type: Stoichiometry
physical entity: Complex (Slit/DCC)
stoichiometric coefficient: 1.0

uniprot Q9TU25 185
type: UnificationXref
id: Q9TU25
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7C6B8 98
organism: Macaca mulatta

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P0CY33 113
xref: PTHR24072:SF192
organism: Candida albicans

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 30

Slit homolog 2 protein
type: ProteinReference
xref: PTHR45836:SF2
xref: uniprot Q9R1B9 38
organism: Mus musculus

uniprot Q09914 205
type: UnificationXref
id: Q09914
db: uniprot

uniprot Q6ZHA3 182
type: UnificationXref
id: Q6ZHA3
db: uniprot

Chemokine (C-X-C motif) receptor 4a
type: ProteinReference
xref: uniprot F1QCB2 131
xref: PTHR10489:SF594
organism: Danio rerio

uniprot Q17031 121
type: UnificationXref
id: Q17031
db: uniprot

uniprot A0A2I3RV08 141
type: UnificationXref
id: A0A2I3RV08
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CX22 23
xref: PTHR45836:SF3
organism: Macaca mulatta

Slit homolog 2 protein
type: ProteinReference
xref: PTHR45836:SF2
xref: uniprot O94813 34
organism: Homo sapiens

Rop-family small GTPase
type: ProteinReference
xref: uniprot A9TLC7 149
organism: Physcomitrella patens

uniprot Q9JI33 69
type: UnificationXref
id: Q9JI33
db: uniprot

Abl
type: Protein
entity reference: Abl
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

RhoA protein
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot A7EEX6 188
organism: Sclerotinia sclerotiorum

Rho-related protein racE
type: ProteinReference
xref: uniprot Q23862 173
organism: Dictyostelium discoideum

DCC
type: Protein
entity reference: DCC
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa40 226
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

Protein sax-3
type: ProteinReference
xref: uniprot G5EBF1 100
organism: Caenorhabditis elegans

uniprot P43146 145
type: UnificationXref
id: P43146
db: uniprot

DCC s32 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DCC
stoichiometric coefficient: 1.0

Slit guidance ligand 3
type: ProteinReference
xref: uniprot H2QRZ2 28
organism: Pan troglodytes

DCC s51 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DCC
stoichiometric coefficient: 1.0

Slit guidance ligand 2
type: ProteinReference
xref: uniprot F7DQ42 25
organism: Xenopus tropicalis

uniprot P0CY33 113
type: UnificationXref
id: P0CY33
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Abl-RIGHT__Abl-_r5
controller: Complex (Slit/Robo/ SrGAP)

Netrin-4
type: ProteinReference
xref: PTHR10574:SF282
xref: uniprot F7A403 49
organism: Macaca mulatta

uniprot E9GYE9 109
type: UnificationXref
id: E9GYE9
db: uniprot

Netrin s50 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Netrin
stoichiometric coefficient: 1.0

ncbitaxon 9544 24
type: UnificationXref
id: 9544
db: ncbitaxon

Robo s30 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Robo
stoichiometric coefficient: 1.0

P00350
type: UnificationXref
id: P00350
db: PANTHER Pathway Component

P00351
type: UnificationXref
id: P00351
db: PANTHER Pathway Component

P00352
type: UnificationXref
id: P00352
db: PANTHER Pathway Component

P00354
type: UnificationXref
id: P00354
db: PANTHER Pathway Component

Danio rerio
type: BioSource
xref: ncbitaxon 7955 9

P00355
type: UnificationXref
id: P00355
db: PANTHER Pathway Component

P00346
type: UnificationXref
id: P00346
db: PANTHER Pathway Component

P00345
type: UnificationXref
id: P00345
db: PANTHER Pathway Component

uniprot A0A2I3SSG9 42
type: UnificationXref
id: A0A2I3SSG9
db: uniprot

P00348
type: UnificationXref
id: P00348
db: PANTHER Pathway Component

P00347
type: UnificationXref
id: P00347
db: PANTHER Pathway Component

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

P00349
type: UnificationXref
id: P00349
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re24 272
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 273
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

uniprot P70658 136
type: UnificationXref
id: P70658
db: uniprot

uniprot F7H9D3 27
type: UnificationXref
id: F7H9D3
db: uniprot

uniprot F7DL02 99
type: UnificationXref
id: F7DL02
db: uniprot

Robo s33 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Robo
stoichiometric coefficient: 1.0

ncbitaxon 9606 30
type: UnificationXref
id: 9606
db: ncbitaxon

PTHR24072:SF168
type: RelationshipXref
id: PTHR24072:SF168
db: PANTHER Family
relationship type: By Homology

uniprot Q6LC82 180
type: UnificationXref
id: Q6LC82
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot G7MIC2 54
organism: Macaca mulatta

Netrin G2
type: ProteinReference
xref: uniprot A0A2I3SSG9 42
organism: Pan troglodytes

Robo
type: Protein
entity reference: Robo
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa13 230
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Mena

uniprot O09118 59
type: UnificationXref
id: O09118
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3S5ZPV2 75
organism: Gallus gallus

uniprot P40224 79
type: UnificationXref
id: P40224
db: uniprot

ncbitaxon 5759 153
type: UnificationXref
id: 5759
db: ncbitaxon

uniprot H2QAD5 55
type: UnificationXref
id: H2QAD5
db: uniprot

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C4M5Z7 154
organism: Entamoeba histolytica

uniprot Q28BZ0 123
type: UnificationXref
id: Q28BZ0
db: uniprot

uniprot F7A567 112
type: UnificationXref
id: F7A567
db: uniprot

P00342
type: UnificationXref
id: P00342
db: PANTHER Pathway Component

C-X-C chemokine receptor type 4
type: ProteinReference
xref: PTHR10489:SF594
xref: uniprot P25930 133
organism: Bos taurus

P00344
type: UnificationXref
id: P00344
db: PANTHER Pathway Component

P00343
type: UnificationXref
id: P00343
db: PANTHER Pathway Component

ncbitaxon 3218 150
type: UnificationXref
id: 3218
db: ncbitaxon

Cdc42
type: Protein
entity reference: Cdc42
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PTHR24072:SF0
type: RelationshipXref
id: PTHR24072:SF0
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r25 282
type: Stoichiometry
physical entity: Complex (Slit/Robo/ SrGAP)
stoichiometric coefficient: 1.0

Slit s28 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Slit
stoichiometric coefficient: 1.0

Rho
type: Protein
entity reference: Rho
feature: ACTIVE 87
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r25 283
type: Stoichiometry
physical entity: DCC
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Cdc42

PARTICIPANT STOICHIOMETRY r25 284
type: Stoichiometry
physical entity: Complex (Slit/Robo/ DCC)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 285
type: Stoichiometry
physical entity: SrGAP
stoichiometric coefficient: 1.0

uniprot A0A3Q1M085 78
type: UnificationXref
id: A0A3Q1M085
db: uniprot

GTP-binding protein rho1
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot Q09914 205
organism: Schizosaccharomyces pombe

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 164

Sdf1
type: Protein
entity reference: Sdf1
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

IDA
type: EvidenceCodeVocabulary

uniprot Q9Y6N7 104
type: UnificationXref
id: Q9Y6N7
db: uniprot

Sdf1
type: ProteinReference
xref: P00346
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.GENERIC.Sdf1
comment: ENTITY_REFERENCE_NOTES=Long Name: Sdf1 Synonym: CXCL12,Chemokine, CXC motif, ligand 12,PBSF,Pre-B cell growth-stimulating factor,Stromal cell-derived factor1 Accession: P00346
member entity reference: Stromal cell-derived factor 1
member entity reference: Uncharacterized protein

Mena
type: ProteinReference
xref: P00345
standard name: Mammalian enabled
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.GENERIC.Mena
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Mammalian enabled Synonym: Ena Accession: P00345
member entity reference: Uncharacterized protein
member entity reference: ENAH, actin regulator
member entity reference: Protein enabled homolog

uniprot P70211 146
type: UnificationXref
id: P70211
db: uniprot

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot Q3LSL6 139
xref: PTHR10489:SF594
organism: Canis lupus familiaris

Roundabout guidance receptor 1
type: ProteinReference
xref: uniprot F7DL02 99
organism: Ornithorhynchus anatinus

ENAH, actin regulator
type: ProteinReference
xref: uniprot A0A0G2K6I4 74
organism: Rattus norvegicus

C-X-C chemokine receptor type 4
type: ProteinReference
xref: uniprot P79394 137
xref: PTHR10489:SF594
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re23 275
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 274
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q05144 172
xref: PTHR24072:SF169
organism: Mus musculus

uniprot F1R2D2 95
type: UnificationXref
id: F1R2D2
db: uniprot

Rac family small GTPase 1
type: ProteinReference
xref: uniprot Q6GL60 179
xref: PTHR24072:SF105
organism: Xenopus tropicalis

uniprot P34148 166
type: UnificationXref
id: P34148
db: uniprot

SLIT2 isoform 4
type: ProteinReference
xref: PTHR45836:SF2
xref: uniprot A0A2I3SS24 4
organism: Pan troglodytes

Uncharacterized protein rac1A
type: ProteinReference
xref: uniprot F1A084 158
xref: PTHR24072:SF281
organism: Dictyostelium purpureum

Complex (Robo/Comm)
type: Complex
component stoichiometry: Comm s34 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: Robo s33 sa15 STOICHIOMETRY ID COMPLEX
component: Comm
component: Robo
feature: COMPLEX BINDING FEATURE s46 a59 235
feature: COMPLEX BINDING FEATURE s46 a59 233
cellular location: endosome

uniprot F1N739 93
type: UnificationXref
id: F1N739
db: uniprot

STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 276
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 277
left: Rac
interaction type: STATE_TRANSITION
right: Rac

uniprot F1Q3G2 17
type: UnificationXref
id: F1Q3G2
db: uniprot

Netrin-4
type: ProteinReference
xref: PTHR10574:SF282
xref: uniprot Q9JI33 69
organism: Mus musculus

uniprot E9PT20 84
type: UnificationXref
id: E9PT20
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 191

Netrin 4
type: ProteinReference
xref: PTHR10574:SF282
xref: uniprot K7C5Y1 57
organism: Pan troglodytes

uniprot O08565 132
type: UnificationXref
id: O08565
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A2I3S7G9 82
organism: Pan troglodytes

uniprot A8XJJ4 91
type: UnificationXref
id: A8XJJ4
db: uniprot

uniprot P08134 203
type: UnificationXref
id: P08134
db: uniprot

ncbitaxon 5786 157
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot B7PHY7 105
type: UnificationXref
id: B7PHY7
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 13

ncbitaxon 9913 11
type: UnificationXref
id: 9913
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r5 262
type: Stoichiometry
physical entity: Abl
stoichiometric coefficient: 1.0

Chemokine (C-X-C motif), receptor 4b
type: ProteinReference
xref: uniprot Q9PTF7 140
xref: PTHR10489:SF594
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r5 261
type: Stoichiometry
physical entity: Abl
stoichiometric coefficient: 1.0

uniprot F1MLJ7 14
type: UnificationXref
id: F1MLJ7
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 110

DCC
type: Protein
entity reference: DCC
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa9 222
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

INHIBITION
type: RelationshipTypeVocabulary

uniprot Q9R1A3 72
type: UnificationXref
id: Q9R1A3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M623 45
organism: Bos taurus

Cxcr4
type: Protein
entity reference: Cxcr4
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa7 218
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot F7FR08 198
type: UnificationXref
id: F7FR08
db: uniprot

Slit homolog 3 protein
type: ProteinReference
xref: uniprot O88280 33
organism: Rattus norvegicus

Slit
type: Protein
entity reference: Slit
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa12 228
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

SrGAP
type: Protein
entity reference: SrGAP
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa5 246
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

uniprot P63001 171
type: UnificationXref
id: P63001
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45836:SF2
xref: uniprot F7H9D3 27
organism: Macaca mulatta

uniprot P35992 40
type: UnificationXref
id: P35992
db: uniprot

uniprot A0A3S5ZPQ6 130
type: UnificationXref
id: A0A3S5ZPQ6
db: uniprot

uniprot F1PAZ4 142
type: UnificationXref
id: F1PAZ4
db: uniprot

uniprot F1A084 158
type: UnificationXref
id: F1A084
db: uniprot

uniprot P40793 115
type: UnificationXref
id: P40793
db: uniprot

DCC
type: Protein
entity reference: DCC
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa2 250
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION
type: InteractionVocabulary

DCC s11 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DCC
stoichiometric coefficient: 1.0

uniprot A0A3Q1LQK7 44
type: UnificationXref
id: A0A3Q1LQK7
db: uniprot

TRANSPORT
type: InteractionVocabulary

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A567 112
xref: PTHR24072:SF136
organism: Monodelphis domestica

ncbitaxon 10090 36
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot F7G4D6 52
type: UnificationXref
id: F7G4D6
db: uniprot

Cdc42 homolog
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot Q17031 121
organism: Anopheles gambiae

Netrin 3
type: ProteinReference
xref: uniprot A0A3Q1LQK7 44
organism: Bos taurus

uniprot A0A3Q1M623 45
type: UnificationXref
id: A0A3Q1M623
db: uniprot

Netrin-G1
type: ProteinReference
xref: uniprot Q9Y2I2 73
organism: Homo sapiens

PTHR24072:SF100
type: RelationshipXref
id: PTHR24072:SF100
db: PANTHER Family
relationship type: By Homology

Cdc42 protein, putative
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot B7PHY7 105
organism: Ixodes scapularis

Robo
type: Protein
entity reference: Robo
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa15 234
cellular location: endosome
comment: SPECIES_TYPE=PROTEIN

Candida albicans
type: BioSource
xref: ncbitaxon 237561 114

uniprot P15153 162
type: UnificationXref
id: P15153
db: uniprot

uniprot Q24567 62
type: UnificationXref
id: Q24567
db: uniprot

PTHR24072:SF17
type: RelationshipXref
id: PTHR24072:SF17
db: PANTHER Family
relationship type: By Homology

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 157

Abl
type: ProteinReference
xref: P00347
standard name: Abelson murine leukemia viral oncogene homolog 1
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by Slit/Robo.PROTEIN.GENERIC.Abl
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Abelson murine leukemia viral oncogene homolog 1 Synonym: c-ABL,p150 Accession: P00347
member entity reference: Tyrosine-protein kinase ABL1
member entity reference: Tyrosine-protein kinase

uniprot Q94124 184
type: UnificationXref
id: Q94124
db: uniprot

Rho family GTPase
type: ProteinReference
xref: uniprot C4M5T0 152
organism: Entamoeba histolytica

GTP-binding protein RHO1
type: ProteinReference
xref: uniprot P06780 201
organism: Saccharomyces cerevisiae

TRANSPORT_LEFT__Complex__Robo_Comm_-RIGHT__Complex__Robo_Comm_-_r26
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 281
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 280
left: Complex (Robo/Comm)
interaction type: TRANSPORT
right: Complex (Robo/Comm)

uniprot P63000 170
type: UnificationXref
id: P63000
db: uniprot

uniprot A0A2I3S4I6 186
type: UnificationXref
id: A0A2I3S4I6
db: uniprot

Roundabout guidance receptor 1
type: ProteinReference
xref: uniprot F6QGK3 96
organism: Monodelphis domestica

Mena
type: Protein
entity reference: Mena
feature: Y Mena s4 a4 rs1
cellular location: plasma membrane
comment: SPECIES_TYPE=PROTEIN

uniprot P62999 169
type: UnificationXref
id: P62999
db: uniprot

uniprot O75094 31
type: UnificationXref
id: O75094
db: uniprot

Rac family small GTPase 3b
type: ProteinReference
xref: uniprot A9JRY8 148
xref: PTHR24072:SF301
organism: Danio rerio

uniprot Q9WVB4 39
type: UnificationXref
id: Q9WVB4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot C3ZIB9 107
organism: Branchiostoma floridae

uniprot P60766 116
type: UnificationXref
id: P60766
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

ncbitaxon 6239 101
type: UnificationXref
id: 6239
db: ncbitaxon

ncbitaxon 9615 16
type: UnificationXref
id: 9615
db: ncbitaxon

PTHR44170:SF8
type: RelationshipXref
id: PTHR44170:SF8
db: PANTHER Family
relationship type: By Homology

Roundabout guidance receptor 1
type: ProteinReference
xref: uniprot A0A2I3SC33 88
organism: Pan troglodytes

ncbitaxon 10228 194
type: UnificationXref
id: 10228
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot B3RIM6 193
organism: Trichoplax adhaerens

uniprot Q5EBF6 81
type: UnificationXref
id: Q5EBF6
db: uniprot

uniprot F1N0C7 48
type: UnificationXref
id: F1N0C7
db: uniprot

Ras-related protein Rac2
type: ProteinReference
xref: uniprot P48554 168
xref: PTHR24072:SF281
organism: Drosophila melanogaster

Complex (Sdf1/Cxcr4)
type: Complex
component stoichiometry: Sdf1 s16 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cxcr4 s17 sa7 STOICHIOMETRY ID COMPLEX
component: Cxcr4
component: Sdf1
feature: ACTIVE 87
feature: COMPLEX BINDING FEATURE s29 a33 217
feature: COMPLEX BINDING FEATURE s29 a33 215
cellular location: plasma membrane

uniprot A0A2I3SS24 4
type: UnificationXref
id: A0A2I3SS24
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 211

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r28
controller: Complex (Slit/Robo/ SrGAP)

uniprot Q62159 208
type: UnificationXref
id: Q62159
db: uniprot

uniprot F1PSS7 15
type: UnificationXref
id: F1PSS7
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LI98 83
organism: Bos taurus

NTN3 isoform 1
type: ProteinReference
xref: uniprot H2QAD5 55
organism: Pan troglodytes

KNOWN_TRANSITION_OMITTED_LEFT__Cytoskeletal_dynamics-RIGHT__Axonal_plasticity-_r11
type: Interaction
xref: KNOWN TRANSITION OMITTED
participant: Axonal plasticity
participant: Cytoskeletal dynamics