Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P62999 246
xref: PTHR24072:SF105
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r1 297
type: Stoichiometry
physical entity: Complex (Netrin/DCC/ UNC-40)
stoichiometric coefficient: 1.0

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70167 188
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r2 294
type: Stoichiometry
physical entity: Ena
stoichiometric coefficient: 1.0

uniprot E2RCV1 148
type: UnificationXref
id: E2RCV1
db: uniprot

uniprot Q7QEJ7 205
type: UnificationXref
id: Q7QEJ7
db: uniprot

PARTICIPANT STOICHIOMETRY r2 293
type: Stoichiometry
physical entity: Ena
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BS96 81
xref: PTHR24213:SF18
organism: Gallus gallus

Netrin-G1
type: ProteinReference
xref: uniprot Q8R4G0 71
organism: Mus musculus

uniprot F7EV15 56
type: UnificationXref
id: F7EV15
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F6TD14 160
organism: Monodelphis domestica

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot P23726 190
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r1 296
type: Stoichiometry
physical entity: DCC/UNC-40
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P23727 191
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r1 295
type: Stoichiometry
physical entity: Netrin
stoichiometric coefficient: 1.0

Netrin-G2
type: ProteinReference
xref: uniprot F7EV15 56
organism: Macaca mulatta

eco ECO:0000250 14
type: UnificationXref
id: ECO:0000250
db: eco

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__MAX_1-RIGHT__MAX_1-_re25
control type: ACTIVATION
controller: Complex (UNC-5/Netrin)

HETERODIMER_ASSOCIATION_LEFT__Netrin-_UNC_5-_DCC_UNC_40-RIGHT__Complex__Netrin_UNC_5__DCC_UNC_40_-_r4
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 286
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 285
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 288
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 287
left: Netrin
left: DCC/UNC-40
left: UNC-5
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Netrin/UNC-5/ DCC/UNC-40)

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F6TAH0 124
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YJC1 242
xref: PTHR24072:SF281
organism: Branchiostoma floridae

PI3K
type: ProteinReference
xref: P00363
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.GENERIC.PI3K
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphotidylinositol 3-kinase Synonym: phosphoinositide-3-kinase Accession: P00363
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
member entity reference: PIK3R5 isoform 2
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit beta
member entity reference: Phosphatidylinositol 3-kinase age-1
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit gamma
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
member entity reference: Phosphoinositide-3-kinase regulatory subunit 3
member entity reference: PIK3CG isoform 1
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
member entity reference: Phosphoinositide 3-kinase regulatory subunit 5
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha
member entity reference: Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
member entity reference: PIK3C2A isoform 5
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: Phosphoinositide-3-kinase regulatory subunit 5
member entity reference: PIK3R1 isoform 1
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Phosphoinositide-3-kinase regulatory subunit 1
member entity reference: AGAP000018-PA
member entity reference: Phosphoinositide-3-kinase regulatory subunit 2
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
member entity reference: LD28067p
member entity reference: PI-3 kinase

Unc-5 netrin receptor A
type: ProteinReference
xref: uniprot A0A2I3SB57 7
organism: Pan troglodytes

uniprot F7A567 222
type: UnificationXref
id: F7A567
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6SW23 159
xref: PTHR10048:SF107
organism: Gallus gallus

Actin-binding LIM protein 1
type: ProteinReference
xref: uniprot O14639 84
xref: PTHR24213:SF18
organism: Homo sapiens

uniprot Q9HF56 237
type: UnificationXref
id: Q9HF56
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70173 189
organism: Rattus norvegicus

uniprot E1BS96 81
type: UnificationXref
id: E1BS96
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F1Q2Q9 155
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F4D5 106
xref: PTHR44170:SF8
organism: Monodelphis domestica

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63001 248
xref: PTHR24072:SF105
organism: Mus musculus

Netrin receptor UNC5C
type: ProteinReference
xref: uniprot Q761X5 39
organism: Rattus norvegicus

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63000 247
xref: PTHR24072:SF105
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A3Q1MMD9 121
organism: Bos taurus

DCC/UNC-40
type: ProteinReference
xref: P00360
standard name: Deleted in colorectal carcinoma
comment: ENTITY_REFERENCE_NOTES=Long Name: Deleted in colorectal carcinoma Synonym: Synonym not specified Accession: P00360
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.RECEPTOR.DCC/UNC-40
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Netrin receptor DCC
member entity reference: DCC netrin 1 receptor
member entity reference: Uncharacterized protein

Netrin receptor UNC5B
type: ProteinReference
xref: uniprot Q8IZJ1 42
organism: Homo sapiens

DCC/UNC-40
type: Protein
entity reference: DCC/UNC-40
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60766 225
xref: PTHR24072:SF136
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 32

ncbitaxon 284812 229
type: UnificationXref
id: 284812
db: ncbitaxon

Rac
type: ProteinReference
xref: P00366
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.GENERIC.Rac
comment: ENTITY_REFERENCE_NOTES=Long Name: Ced-10 Synonym: Rac GTPase Accession: P00366
member entity reference: Rac family small GTPase 1b
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Rac family small GTPase 1a
member entity reference: GTPase cRac1A
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Rac family small GTPase 3a
member entity reference: Uncharacterized protein
member entity reference: Rac family small GTPase 3b
member entity reference: Rac family small GTPase 1
member entity reference: Rac family small GTPase 2

uniprot Q24567 68
type: UnificationXref
id: Q24567
db: uniprot

Rho-related GTP-binding protein RhoU
type: ProteinReference
xref: uniprot Q7L0Q8 233
organism: Homo sapiens

uniprot A7MB18 50
type: UnificationXref
id: A7MB18
db: uniprot

uniprot P23726 190
type: UnificationXref
id: P23726
db: uniprot

uniprot H2PXY8 176
type: UnificationXref
id: H2PXY8
db: uniprot

uniprot P50552 115
type: UnificationXref
id: P50552
db: uniprot

uniprot A0A0G2K344 134
type: UnificationXref
id: A0A0G2K344
db: uniprot

uniprot F1Q2Q9 155
type: UnificationXref
id: F1Q2Q9
db: uniprot

uniprot A5D7J5 213
type: UnificationXref
id: A5D7J5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42336 195
xref: PTHR10048:SF107
organism: Homo sapiens

uniprot A0A0G2K6I4 110
type: UnificationXref
id: A0A0G2K6I4
db: uniprot

uniprot P62999 246
type: UnificationXref
id: P62999
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot P42338 197
organism: Homo sapiens

Netrin 1
type: ProteinReference
xref: PTHR10574:SF378
xref: uniprot H2QC90 61
organism: Pan troglodytes

Phosphatidylinositol 3-kinase age-1
type: ProteinReference
xref: uniprot Q94125 210
xref: PTHR10048:SF14
organism: Caenorhabditis elegans

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42337 196
xref: PTHR10048:SF107
organism: Mus musculus

uniprot A0A2I3SXZ1 47
type: UnificationXref
id: A0A2I3SXZ1
db: uniprot

uniprot P63001 248
type: UnificationXref
id: P63001
db: uniprot

Ras homolog family member U
type: ProteinReference
xref: uniprot F6Y381 221
organism: Xenopus tropicalis

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 69

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N0C7 52
xref: PTHR10574:SF378
organism: Bos taurus

uniprot Q6RUV5 255
type: UnificationXref
id: Q6RUV5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF325
xref: uniprot F7GY91 244
organism: Macaca mulatta

uniprot P32871 194
type: UnificationXref
id: P32871
db: uniprot

PTHR10574:SF282
type: RelationshipXref
id: PTHR10574:SF282
db: PANTHER Family
relationship type: By Homology

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: uniprot P70460 116
organism: Mus musculus

uniprot O70167 188
type: UnificationXref
id: O70167
db: uniprot

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: uniprot F1MBU9 153
xref: PTHR10048:SF30
organism: Bos taurus

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

Cell division cycle 42
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q28BZ0 231
organism: Xenopus tropicalis

uniprot Q63788 201
type: UnificationXref
id: Q63788
db: uniprot

NFATC3 isoform 2
type: ProteinReference
xref: PTHR12533:SF6
xref: uniprot K7DDW5 97
organism: Pan troglodytes

Netrin G1
type: ProteinReference
xref: uniprot A0A2I3SXZ1 47
organism: Pan troglodytes

MAX-1
type: ProteinReference
xref: P00365
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.GENERIC.MAX-1
comment: ENTITY_REFERENCE_NOTES=Long Name: MAX-1 Synonym: Motor AXon guidance MAX-1 Accession: P00365
member entity reference: Protein CBR-MAX-1
member entity reference: MAX-1A

uniprot D3ZVF3 145
type: UnificationXref
id: D3ZVF3
db: uniprot

uniprot F1MQ73 21
type: UnificationXref
id: F1MQ73
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot F6W7C8 163
organism: Macaca mulatta

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Complex (Netrin/UNC-5/ DCC/UNC-40)

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot E2RQM0 122
xref: PTHR10336:SF25
organism: Canis lupus familiaris

uniprot Q8BTI9 207
type: UnificationXref
id: Q8BTI9
db: uniprot

Phospholipase C
type: Protein
entity reference: Phospholipase C
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q7L0Q8 233
type: UnificationXref
id: Q7L0Q8
db: uniprot

Axon guidance mediated by netrin
type: Pathway
pathway component: STATE_TRANSITION_LEFT__cdc42-RIGHT__cdc42-_re26
pathway component: PHYSICAL_STIMULATION
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__transcription-RIGHT__Cytoskeletal_dynamics-_re42
pathway component: HETERODIMER_ASSOCIATION_LEFT__Netrin-_UNC_5-_DCC_UNC_40-RIGHT__Complex__Netrin_UNC_5__DCC_UNC_40_-_r4
pathway component: STATE_TRANSITION_LEFT__MAX_1-RIGHT__MAX_1-_re25
pathway component: STATE_TRANSITION_LEFT__Phospholipase_C-RIGHT__Phospholipase_C-_re30
pathway component: HETERODIMER_ASSOCIATION_LEFT__Netrin-_UNC_5-RIGHT__Complex__UNC_5_Netrin_-_r17
pathway component: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_re28
pathway component: STATE_TRANSITION_LEFT__Ena-RIGHT__Ena-_r2
pathway component: STATE_TRANSITION_LEFT__Ablim-RIGHT__Ablim-_r7
pathway component: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_re27
pathway component: HETERODIMER_ASSOCIATION_LEFT__Netrin-_DCC_UNC_40-RIGHT__Complex__Netrin_DCC__UNC_40_-_r1
pathway component: STATE_TRANSITION_LEFT__NFAT-RIGHT__NFAT-_re29
xref: PANTHER Pathway P00009 1
comment: MODEL_NOTES=Panther Pathway: P00009 Axons are guided along specific pathways by attractive and repulsive cues during the establishment of the nervous system network. Netrin is one these cues. Netrin is a chemoattractant to axon growth cones through the receptors DCC and UNC-5. However, after axonal growth cones cross the nervous system midline, they change their responsiveness to midline guidance cues: they become repelled by the repellent Slit and simultaneously lose responsiveness to the attractant netrin. This is large due to the activation of the Slit receptor Roundabout silences the attractive effect of netrin-1. Medline=12471249 Medline=12677003 Medline=14682358 PMID: 12471249 PMID: 12677003 PMID: 14682358

Netrin-A
type: ProteinReference
xref: uniprot Q24567 68
organism: Drosophila melanogaster

Netrin-B
type: ProteinReference
xref: uniprot Q24568 70
organism: Drosophila melanogaster

Netrin
type: ProteinReference
xref: uniprot Q9NL28 77
organism: Ciona intestinalis

BOOLEAN_LOGIC_GATE_OR
type: Control
xref: BOOLEAN LOGIC GATE OR
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_re27

uniprot E2R3Q6 51
type: UnificationXref
id: E2R3Q6
db: uniprot

uniprot Q12968 99
type: UnificationXref
id: Q12968
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q9Z1L0 212
xref: PTHR10048:SF33
organism: Rattus norvegicus

Netrin s2 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Netrin
stoichiometric coefficient: 1.0

uniprot A0A2I3SB57 7
type: UnificationXref
id: A0A2I3SB57
db: uniprot

uniprot P19174 130
type: UnificationXref
id: P19174
db: uniprot

uniprot G3V6X3 58
type: UnificationXref
id: G3V6X3
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 8

Complex (Netrin/DCC/ UNC-40)
type: Complex
component stoichiometry: Netrin s2 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: DCC UNC 40 s4 sa2 STOICHIOMETRY ID COMPLEX
component: DCC/UNC-40
component: Netrin
feature: COMPLEX BINDING FEATURE s6 a6 258
feature: ACTIVE 85
feature: COMPLEX BINDING FEATURE s6 a6 260
cellular location: cytosol

Netrin receptor DCC
type: ProteinReference
xref: PTHR44170:SF8
xref: uniprot Q63155 109
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BBM1 166
xref: PTHR10048:SF30
organism: Monodelphis domestica

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 55

uniprot H9FVU5 180
type: UnificationXref
id: H9FVU5
db: uniprot

uniprot F1PDD9 94
type: UnificationXref
id: F1PDD9
db: uniprot

uniprot O09118 64
type: UnificationXref
id: O09118
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q8CFN2 234
xref: PTHR24072:SF136
organism: Rattus norvegicus

uniprot F6Q8P2 24
type: UnificationXref
id: F6Q8P2
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Netrin-_UNC_5-RIGHT__Complex__UNC_5_Netrin_-_r17
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 274
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 276
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 275
left: Netrin
left: UNC-5
interaction type: HETERODIMER_ASSOCIATION
right: Complex (UNC-5/Netrin)

KNOWN_TRANSITION_OMITTED_LEFT__transcription-RIGHT__Cytoskeletal_dynamics-_re42
type: Interaction
xref: KNOWN TRANSITION OMITTED
participant: transcription
participant: Cytoskeletal dynamics

ncbitaxon 7165 206
type: UnificationXref
id: 7165
db: ncbitaxon

Rac family small GTPase 3a
type: ProteinReference
xref: uniprot Q6DGB7 252
xref: PTHR24072:SF301
organism: Danio rerio

uniprot O95185 33
type: UnificationXref
id: O95185
db: uniprot

ncbitaxon 6669 219
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot F6TAH0 124
type: UnificationXref
id: F6TAH0
db: uniprot

uniprot A0A1D5QJY6 136
type: UnificationXref
id: A0A1D5QJY6
db: uniprot

uniprot G5ED24 240
type: UnificationXref
id: G5ED24
db: uniprot

DCC netrin 1 receptor
type: ProteinReference
xref: PTHR44170:SF8
xref: uniprot A0A2I3RV08 103
organism: Pan troglodytes

Netrin 2-like (Chicken)
type: ProteinReference
xref: uniprot G3V6X3 58
organism: Rattus norvegicus

uniprot A0A3Q1M623 49
type: UnificationXref
id: A0A3Q1M623
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ablim-RIGHT__Ablim-_r7
controller: Rac

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot E2RPB0 151
organism: Canis lupus familiaris

uniprot A0A2I3RH39 137
type: UnificationXref
id: A0A2I3RH39
db: uniprot

uniprot A0A0G2K9C0 111
type: UnificationXref
id: A0A0G2K9C0
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A2I3T7A8 139
xref: PTHR10048:SF107
organism: Pan troglodytes

uniprot A8X936 239
type: UnificationXref
id: A8X936
db: uniprot

uniprot A0A1D5RJQ0 88
type: UnificationXref
id: A0A1D5RJQ0
db: uniprot

DCC/UNC-40
type: Protein
entity reference: DCC/UNC-40
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa5 267
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q03173 117
type: UnificationXref
id: Q03173
db: uniprot

uniprot Q924Z9 72
type: UnificationXref
id: Q924Z9
db: uniprot

uniprot F7FDA0 171
type: UnificationXref
id: F7FDA0
db: uniprot

uniprot F7DUD6 168
type: UnificationXref
id: F7DUD6
db: uniprot

uniprot H2QPW9 27
type: UnificationXref
id: H2QPW9
db: uniprot

PARTICIPANT STOICHIOMETRY re30 273
type: Stoichiometry
physical entity: Phospholipase C
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7DUD6 168
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY re30 272
type: Stoichiometry
physical entity: Phospholipase C
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR12533:SF11
xref: uniprot A0A1D5RJQ0 88
organism: Macaca mulatta

Netrin receptor DCC
type: ProteinReference
xref: PTHR44170:SF8
xref: uniprot P43146 107
organism: Homo sapiens

Protein enabled homolog
type: ProteinReference
xref: uniprot Q03173 117
organism: Mus musculus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Ena

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q64143 203
organism: Mus musculus

uniprot F1PS03 123
type: UnificationXref
id: F1PS03
db: uniprot

uniprot Q6UXZ4 38
type: UnificationXref
id: Q6UXZ4
db: uniprot

uniprot P23727 191
type: UnificationXref
id: P23727
db: uniprot

uniprot O42140 65
type: UnificationXref
id: O42140
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: cdc42

MAX-1
type: Protein
entity reference: MAX-1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2R4F5 96
type: UnificationXref
id: H2R4F5
db: uniprot

uniprot Q14934 101
type: UnificationXref
id: Q14934
db: uniprot

uniprot Q17031 230
type: UnificationXref
id: Q17031
db: uniprot

PTHR10574:SF378
type: RelationshipXref
id: PTHR10574:SF378
db: PANTHER Family
relationship type: By Homology

Netrin-1a
type: ProteinReference
xref: uniprot O42140 65
xref: PTHR10574:SF378
organism: Danio rerio

uniprot Q8K1S3 44
type: UnificationXref
id: Q8K1S3
db: uniprot

Netrin s5 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Netrin
stoichiometric coefficient: 1.0

uniprot F6TD14 160
type: UnificationXref
id: F6TD14
db: uniprot

PIK3R1 isoform 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot A0A2I3SIY1 138
organism: Pan troglodytes

Netrin receptor UNC5C
type: ProteinReference
xref: uniprot F7HIS3 26
organism: Macaca mulatta

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_re28
control type: ACTIVATION
controller: Complex (Netrin/DCC/ UNC-40)

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b
type: ProteinReference
xref: PTHR12533:SF6
xref: uniprot A0A0G2JTY4 86
organism: Rattus norvegicus

ncbitaxon 10090 32
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot Q05144 249
type: UnificationXref
id: Q05144
db: uniprot

uniprot F7GAP5 173
type: UnificationXref
id: F7GAP5
db: uniprot

ncbitaxon 9031 41
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot Q9TU25 257
type: UnificationXref
id: Q9TU25
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7FDA0 171
xref: PTHR10048:SF33
organism: Monodelphis domestica

Netrin
type: ProteinReference
xref: P00357
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.GENERIC.Netrin
comment: ENTITY_REFERENCE_NOTES=Long Name: Netrin Synonym: Netrin-1 Accession: P00357
member entity reference: Uncharacterized protein
member entity reference: Netrin 1
member entity reference: Netrin G1
member entity reference: NTN3 isoform 1
member entity reference: Netrin-4
member entity reference: Netrin
member entity reference: Netrin 4
member entity reference: Netrin 3
member entity reference: NTN4 protein
member entity reference: Netrin-3
member entity reference: Netrin-1a
member entity reference: Netrin-1
member entity reference: Netrin 2-like (Chicken)
member entity reference: Netrin-G1
member entity reference: Netrin-G2
member entity reference: Netrin-A
member entity reference: Netrin G2
member entity reference: Netrin-B

Phosphoinositide-3-kinase regulatory subunit 3
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot A0A2I3RH39 137
organism: Pan troglodytes

uniprot P60952 226
type: UnificationXref
id: P60952
db: uniprot

uniprot A0A3Q1MMD9 121
type: UnificationXref
id: A0A3Q1MMD9
db: uniprot

Complex (Netrin/UNC-5/ DCC/UNC-40)
type: Complex
component stoichiometry: UNC 5 s9 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Netrin s5 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: DCC UNC 40 s10 sa5 STOICHIOMETRY ID COMPLEX
component: UNC-5
component: Netrin
component: DCC/UNC-40
feature: COMPLEX BINDING FEATURE s12 a13 262
feature: COMPLEX BINDING FEATURE s12 a13 266
feature: COMPLEX BINDING FEATURE s12 a13 264
feature: ACTIVE 85
cellular location: cytosol

NTN4 protein
type: ProteinReference
xref: PTHR10574:SF282
xref: uniprot A7MB18 50
organism: Bos taurus

PI3K
type: Protein
entity reference: PI3K
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7BZL6 167
type: UnificationXref
id: F7BZL6
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 10

uniprot P16885 129
type: UnificationXref
id: P16885
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 4

uniprot P08487 127
type: UnificationXref
id: P08487
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot Q62077 131
organism: Mus musculus

uniprot C3YJC1 242
type: UnificationXref
id: C3YJC1
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 158

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q9TU25 257
xref: PTHR24072:SF169
organism: Bos taurus

Nuclear factor of activated T-cells, cytoplasmic 3
type: ProteinReference
xref: PTHR12533:SF6
xref: uniprot Q12968 99
organism: Homo sapiens

Unc-5 netrin receptor A
type: ProteinReference
xref: uniprot F1MQ73 21
organism: Bos taurus

uniprot A0A1D5QS85 6
type: UnificationXref
id: A0A1D5QS85
db: uniprot

uniprot F6SW23 159
type: UnificationXref
id: F6SW23
db: uniprot

uniprot P60766 225
type: UnificationXref
id: P60766
db: uniprot

uniprot O95631 67
type: UnificationXref
id: O95631
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot G7MGQ5 175
xref: PTHR10155:SF2
organism: Macaca mulatta

uniprot P60953 227
type: UnificationXref
id: P60953
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F7BVQ1 125
xref: PTHR10336:SF25
organism: Monodelphis domestica

DCC netrin 1 receptor
type: ProteinReference
xref: PTHR44170:SF8
xref: uniprot F1PAZ4 104
organism: Canis lupus familiaris

uniprot P42338 197
type: UnificationXref
id: P42338
db: uniprot

uniprot B7PHY7 214
type: UnificationXref
id: B7PHY7
db: uniprot

uniprot A0A2J8MGP0 140
type: UnificationXref
id: A0A2J8MGP0
db: uniprot

UNC5B protein
type: ProteinReference
xref: uniprot A5PJP9 11
organism: Bos taurus

uniprot A0A1D5QIU6 3
type: UnificationXref
id: A0A1D5QIU6
db: uniprot

uniprot F6Z0J4 165
type: UnificationXref
id: F6Z0J4
db: uniprot

ncbitaxon 8364 55
type: UnificationXref
id: 8364
db: ncbitaxon

cytosol
type: CellularLocationVocabulary
xref: go GO:0005829 2

MAX-1
type: Protein
entity reference: MAX-1
feature: ACTIVE 85
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 215

UNC-5
type: ProteinReference
xref: P00356
comment: ENTITY_REFERENCE_NOTES=Long Name: UNC-5 Synonym: Dunc5,UNC5H Accession: P00356
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.RECEPTOR.UNC-5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Unc-5 netrin receptor B
member entity reference: Netrin receptor UNC5C
member entity reference: UNC5C isoform 2
member entity reference: Netrin receptor UNC5B
member entity reference: Unc-5 netrin receptor C
member entity reference: Netrin receptor unc-5
member entity reference: Netrin receptor UNC5D
member entity reference: UNC5B protein
member entity reference: Uncharacterized protein
member entity reference: Netrin receptor UNC5A
member entity reference: UNC5D isoform 4
member entity reference: Unc-5 netrin receptor A
member entity reference: Unc-5 netrin receptor D
member entity reference: Protein CBR-UNC-5

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P08487 127
xref: PTHR10336:SF173
organism: Bos taurus

Cell division control protein 42 homolog isoform 2
type: ProteinReference
xref: uniprot F6RBZ7 220
xref: PTHR24072:SF337
organism: Macaca mulatta

DCC UNC 40 s10 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DCC/UNC-40
stoichiometric coefficient: 1.0

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60952 226
xref: PTHR24072:SF136
organism: Canis lupus familiaris

uniprot Q9JHG7 211
type: UnificationXref
id: Q9JHG7
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60953 227
xref: PTHR24072:SF136
organism: Homo sapiens

Netrin 1
type: ProteinReference
xref: uniprot F7G4D6 57
xref: PTHR10574:SF378
organism: Monodelphis domestica

Ena
type: Protein
entity reference: Ena
feature: ACTIVE 85
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1Q3M8 156
type: UnificationXref
id: F1Q3M8
db: uniprot

uniprot F1PUV2 22
type: UnificationXref
id: F1PUV2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MHX0 20
organism: Bos taurus

ncbitaxon 10116 19
type: UnificationXref
id: 10116
db: ncbitaxon

ncbitaxon 13616 25
type: UnificationXref
id: 13616
db: ncbitaxon

ABLIM1 isoform 5
type: ProteinReference
xref: PTHR24213:SF18
xref: uniprot H2R0M2 83
organism: Pan troglodytes

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: uniprot Q8K120 102
xref: PTHR12533:SF11
organism: Mus musculus

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 17

BOOLEAN_LOGIC_GATE_OR
type: RelationshipTypeVocabulary

Nuclear factor of activated T-cells, cytoplasmic 3
type: ProteinReference
xref: PTHR12533:SF6
xref: uniprot P97305 98
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QM53 157
xref: PTHR10155:SF2
organism: Ornithorhynchus anatinus

Rho-related GTP-binding protein RhoU
type: ProteinReference
xref: uniprot A5D7J5 213
organism: Bos taurus

uniprot P97305 98
type: UnificationXref
id: P97305
db: uniprot

GTPase cRac1A
type: ProteinReference
xref: uniprot Q6LC82 254
xref: PTHR24072:SF105
organism: Gallus gallus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Phospholipase C

uniprot F6XSJ9 243
type: UnificationXref
id: F6XSJ9
db: uniprot

Netrin receptor UNC5D
type: ProteinReference
xref: uniprot Q6UXZ4 38
organism: Homo sapiens

uniprot E2RC29 16
type: UnificationXref
id: E2RC29
db: uniprot

uniprot O08721 29
type: UnificationXref
id: O08721
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O35904 186
organism: Mus musculus

PI3K
type: Protein
entity reference: PI3K
feature: ACTIVE 85
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Netrin receptor UNC5D
type: ProteinReference
xref: uniprot F1LW30 18
organism: Rattus norvegicus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 41

ncbitaxon 7719 78
type: UnificationXref
id: 7719
db: ncbitaxon

Nuclear factor of activated T cells 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot F1PDD9 94
organism: Canis lupus familiaris

Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
type: ProteinReference
xref: uniprot D3ZTF6 144
xref: PTHR10048:SF28
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__cdc42-RIGHT__cdc42-_re26
control type: ACTIVATION
controller: Complex (Netrin/UNC-5/ DCC/UNC-40)

uniprot A0A1D5QLW6 118
type: UnificationXref
id: A0A1D5QLW6
db: uniprot

uniprot Q61194 200
type: UnificationXref
id: Q61194
db: uniprot

uniprot F6W7C8 163
type: UnificationXref
id: F6W7C8
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q01112 228
xref: PTHR24072:SF192
organism: Schizosaccharomyces pombe

Netrin 1
type: ProteinReference
xref: uniprot F7CBX5 54
xref: PTHR10574:SF378
organism: Xenopus tropicalis

Unc-5 netrin receptor B
type: ProteinReference
xref: uniprot E2RC29 16
organism: Canis lupus familiaris

Rac family small GTPase 1a
type: ProteinReference
xref: uniprot Q7ZSZ9 256
xref: PTHR24072:SF105
organism: Danio rerio

uniprot D4A5Q1 146
type: UnificationXref
id: D4A5Q1
db: uniprot

uniprot Q63789 202
type: UnificationXref
id: Q63789
db: uniprot

uniprot P70460 116
type: UnificationXref
id: P70460
db: uniprot

Ena
type: Protein
entity reference: Ena
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2R0M2 83
type: UnificationXref
id: H2R0M2
db: uniprot

ncbitaxon 284811 238
type: UnificationXref
id: 284811
db: ncbitaxon

PTHR10336:SF25
type: RelationshipXref
id: PTHR10336:SF25
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: RelationshipTypeVocabulary

Cytoskeletal dynamics
type: Pathway

PTHR15593:SF2
type: RelationshipXref
id: PTHR15593:SF2
db: PANTHER Family
relationship type: By Homology

PIK3R5 isoform 2
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot A0A2J8MGP0 140
organism: Pan troglodytes

uniprot P42337 196
type: UnificationXref
id: P42337
db: uniprot

uniprot P26450 192
type: UnificationXref
id: P26450
db: uniprot

PIK3C2A isoform 5
type: ProteinReference
xref: uniprot H2Q383 177
xref: PTHR10048:SF28
organism: Pan troglodytes

PTHR10155:SF3
type: RelationshipXref
id: PTHR10155:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q8WYR1 208
type: UnificationXref
id: Q8WYR1
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot E2RCV1 148
organism: Canis lupus familiaris

uniprot Q5U1Y2 251
type: UnificationXref
id: Q5U1Y2
db: uniprot

Netrin-3
type: ProteinReference
xref: uniprot O00634 63
organism: Homo sapiens

uniprot F7F4D5 106
type: UnificationXref
id: F7F4D5
db: uniprot

uniprot F7BVQ1 125
type: UnificationXref
id: F7BVQ1
db: uniprot

uniprot Q9VXH3 133
type: UnificationXref
id: Q9VXH3
db: uniprot

uniprot O46404 187
type: UnificationXref
id: O46404
db: uniprot

uniprot Q8K120 102
type: UnificationXref
id: Q8K120
db: uniprot

PTHR10155:SF2
type: RelationshipXref
id: PTHR10155:SF2
db: PANTHER Family
relationship type: By Homology

PTHR10155:SF1
type: RelationshipXref
id: PTHR10155:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F6VXG1 162
type: UnificationXref
id: F6VXG1
db: uniprot

uniprot Q8R4G0 71
type: UnificationXref
id: Q8R4G0
db: uniprot

uniprot O00443 182
type: UnificationXref
id: O00443
db: uniprot

Netrin-1
type: ProteinReference
xref: uniprot Q924Z9 72
xref: PTHR10574:SF378
organism: Rattus norvegicus

uniprot F6Y841 164
type: UnificationXref
id: F6Y841
db: uniprot

Cdc42 homolog
type: ProteinReference
xref: uniprot P40793 224
xref: PTHR24072:SF192
organism: Drosophila melanogaster

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A2I3SHP7 120
organism: Pan troglodytes

uniprot A0A1D5R8E9 119
type: UnificationXref
id: A0A1D5R8E9
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P19174 130
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot Q9JHG7 211
xref: PTHR10048:SF34
organism: Mus musculus

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot Q6RUV5 255
xref: PTHR24072:SF105
organism: Rattus norvegicus

MAX-1A
type: ProteinReference
xref: uniprot G5ED24 240
xref: PTHR22903:SF8
organism: Caenorhabditis elegans

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot P15153 245
xref: PTHR24072:SF169
organism: Homo sapiens

uniprot H2Q383 177
type: UnificationXref
id: H2Q383
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 13

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot F7EP57 169
organism: Macaca mulatta

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 36

uniprot O00634 63
type: UnificationXref
id: O00634
db: uniprot

uniprot A0A3Q1LQK7 48
type: UnificationXref
id: A0A3Q1LQK7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Q8P2 24
organism: Monodelphis domestica

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot D4A0I8 91
organism: Rattus norvegicus

uniprot F7CBX5 54
type: UnificationXref
id: F7CBX5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6VXG1 162
xref: PTHR10048:SF107
organism: Xenopus tropicalis

uniprot F7F3S0 170
type: UnificationXref
id: F7F3S0
db: uniprot

Rho-related GTP-binding protein RhoU
type: ProteinReference
xref: uniprot Q9EQT3 236
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q8BTI9 207
xref: PTHR10048:SF33
organism: Mus musculus

uniprot K7C5Y1 62
type: UnificationXref
id: K7C5Y1
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K5T3 135
organism: Rattus norvegicus

uniprot F7GY91 244
type: UnificationXref
id: F7GY91
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot E9GYE9 218
organism: Daphnia pulex

uniprot O00750 184
type: UnificationXref
id: O00750
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: NFAT

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O08908 185
organism: Mus musculus

Netrin-1
type: ProteinReference
xref: uniprot O95631 67
xref: PTHR10574:SF378
organism: Homo sapiens

Phosphoinositide-3-kinase regulatory subunit 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F6Z0J4 165
organism: Xenopus tropicalis

uniprot H2QFS6 178
type: UnificationXref
id: H2QFS6
db: uniprot

uniprot P50551 114
type: UnificationXref
id: P50551
db: uniprot

Rac family small GTPase 1b
type: ProteinReference
xref: uniprot Q29RC5 250
xref: PTHR24072:SF105
organism: Danio rerio

Netrin-G2
type: ProteinReference
xref: uniprot Q96CW9 74
organism: Homo sapiens

uniprot Q26261 35
type: UnificationXref
id: Q26261
db: uniprot

Netrin receptor DCC
type: ProteinReference
xref: uniprot P70211 108
xref: PTHR44170:SF8
organism: Mus musculus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__NFAT-RIGHT__NFAT-_re29
control type: ACTIVATION
controller: Complex (Netrin/DCC/ UNC-40)

uniprot O08722 30
type: UnificationXref
id: O08722
db: uniprot

uniprot Q29RC5 250
type: UnificationXref
id: Q29RC5
db: uniprot

PTHR12582:SF47
type: RelationshipXref
id: PTHR12582:SF47
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9544 4
type: UnificationXref
id: 9544
db: ncbitaxon

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
type: ProteinReference
xref: uniprot D3ZVF3 145
xref: PTHR10048:SF30
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RRI0 105
xref: PTHR44170:SF8
organism: Macaca mulatta

uniprot D3ZFJ0 143
type: UnificationXref
id: D3ZFJ0
db: uniprot

Netrin-1
type: ProteinReference
xref: uniprot O09118 64
xref: PTHR10574:SF378
organism: Mus musculus

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot Q63789 202
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: uniprot Q63788 201
xref: PTHR10155:SF1
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P32871 194
xref: PTHR10048:SF107
organism: Bos taurus

uniprot Q96CW9 74
type: UnificationXref
id: Q96CW9
db: uniprot

Protein CBR-UNC-5
type: ProteinReference
xref: PTHR12582:SF47
xref: uniprot A8XWR5 12
organism: Caenorhabditis briggsae

Nuclear factor of activated T-cells, cytoplasmic 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot Q13469 100
organism: Homo sapiens

Ablim
type: Protein
entity reference: Ablim
feature: ACTIVE 85
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Rac

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 206

UNC5C isoform 2
type: ProteinReference
xref: uniprot H2QPW9 27
organism: Pan troglodytes

UNC-5
type: Protein
entity reference: UNC-5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QQJ4 5
type: UnificationXref
id: A0A1D5QQJ4
db: uniprot

Phosphoinositide-3-kinase regulatory subunit 5
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot E2RLD1 150
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7F3S0 170
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot E1BE66 147
organism: Bos taurus

AGAP000018-PA
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q7QEJ7 205
organism: Anopheles gambiae

Netrin receptor UNC5C
type: ProteinReference
xref: uniprot O08747 31
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re27 283
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re27 284
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

Cell division cycle 42
type: ProteinReference
xref: uniprot Q52WY2 232
xref: PTHR24072:SF337
organism: Danio rerio

uniprot Q9R1A3 79
type: UnificationXref
id: Q9R1A3
db: uniprot

uniprot F1Q2N1 23
type: UnificationXref
id: F1Q2N1
db: uniprot

uniprot E9QAN8 152
type: UnificationXref
id: E9QAN8
db: uniprot

uniprot Q94125 210
type: UnificationXref
id: Q94125
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Phospholipase_C-RIGHT__Phospholipase_C-_re30
control type: ACTIVATION
controller: Complex (Netrin/DCC/ UNC-40)

uniprot Q8CFN2 234
type: UnificationXref
id: Q8CFN2
db: uniprot

Netrin
type: Protein
entity reference: Netrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa7 271
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Netrin receptor unc-5
type: ProteinReference
xref: uniprot Q26261 35
xref: PTHR12582:SF47
organism: Caenorhabditis elegans

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot P48736 198
organism: Homo sapiens

PTHR24072:SF337
type: RelationshipXref
id: PTHR24072:SF337
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot H2PXY8 176
organism: Pan troglodytes

uniprot Q7ZSZ9 256
type: UnificationXref
id: Q7ZSZ9
db: uniprot

uniprot F7EP57 169
type: UnificationXref
id: F7EP57
db: uniprot

STATE_TRANSITION_LEFT__Phospholipase_C-RIGHT__Phospholipase_C-_re30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 273
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 272
left: Phospholipase C
interaction type: STATE_TRANSITION
right: Phospholipase C

uniprot P63000 247
type: UnificationXref
id: P63000
db: uniprot

uniprot H2R9V2 28
type: UnificationXref
id: H2R9V2
db: uniprot

uniprot A0A3Q1LGH1 9
type: UnificationXref
id: A0A3Q1LGH1
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 217

uniprot A0A2I3RV08 103
type: UnificationXref
id: A0A2I3RV08
db: uniprot

uniprot A0A1D5QLW3 87
type: UnificationXref
id: A0A1D5QLW3
db: uniprot

Complex (UNC-5/Netrin)
type: Complex
component stoichiometry: Netrin s13 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: UNC 5 s11 sa6 STOICHIOMETRY ID COMPLEX
component: Netrin
component: UNC-5
feature: COMPLEX BINDING FEATURE s34 a39 268
feature: COMPLEX BINDING FEATURE s34 a39 270
feature: ACTIVE 85
cellular location: cytosol

cdc42
type: Protein
entity reference: cdc42
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Netrin
type: Protein
entity reference: Netrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa1 259
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E2RLD1 150
type: UnificationXref
id: E2RLD1
db: uniprot

cdc42
type: Protein
entity reference: cdc42
feature: ACTIVE 85
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 14

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_re27
control type: ACTIVATION
controller: Complex (Netrin/DCC/ UNC-40)

uniprot Q7T2Z5 40
type: UnificationXref
id: Q7T2Z5
db: uniprot

UNC 5 s9 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UNC-5
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P27986 193
organism: Homo sapiens

uniprot Q90694 235
type: UnificationXref
id: Q90694
db: uniprot

NFAT
type: Protein
entity reference: NFAT
feature: ACTIVE 85
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24072:SF325
type: RelationshipXref
id: PTHR24072:SF325
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__cdc42-RIGHT__cdc42-_re26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 290
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 289
left: cdc42
interaction type: STATE_TRANSITION
right: cdc42

uniprot G7MGQ5 175
type: UnificationXref
id: G7MGQ5
db: uniprot

uniprot Q63155 109
type: UnificationXref
id: Q63155
db: uniprot

Netrin receptor UNC5B
type: ProteinReference
xref: uniprot Q8K1S3 44
organism: Mus musculus

STATE_TRANSITION_LEFT__MAX_1-RIGHT__MAX_1-_re25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 291
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 292
left: MAX-1
interaction type: STATE_TRANSITION
right: MAX-1

Netrin receptor UNC5A
type: ProteinReference
xref: uniprot Q8K1S4 45
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r7 277
type: Stoichiometry
physical entity: Ablim
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 278
type: Stoichiometry
physical entity: Ablim
stoichiometric coefficient: 1.0

Netrin receptor UNC5D
type: ProteinReference
xref: uniprot Q8K1S2 43
organism: Mus musculus

uniprot Q13469 100
type: UnificationXref
id: Q13469
db: uniprot

UNC5D isoform 4
type: ProteinReference
xref: uniprot H2R9V2 28
organism: Pan troglodytes

NFATC4 isoform 9
type: ProteinReference
xref: uniprot A0A2I3TJ60 89
xref: PTHR12533:SF11
organism: Pan troglodytes

Netrin receptor UNC5A
type: ProteinReference
xref: uniprot O08721 29
organism: Rattus norvegicus

Ena
type: ProteinReference
xref: P00361
standard name: Enabled
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.GENERIC.Ena
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Enabled Synonym: Unc-34,VASP,Vasodialator-stimulated phosphoprotein Accession: P00361
member entity reference: Vasodilator-stimulated phosphoprotein
member entity reference: Protein enabled homolog
member entity reference: ENAH, actin regulator
member entity reference: Uncharacterized protein

Netrin receptor UNC5B
type: ProteinReference
xref: uniprot O08722 30
organism: Rattus norvegicus

Unc-5 netrin receptor C
type: ProteinReference
xref: uniprot A0A3Q1LGH1 9
organism: Bos taurus

uniprot F1N0C7 52
type: UnificationXref
id: F1N0C7
db: uniprot

uniprot P70211 108
type: UnificationXref
id: P70211
db: uniprot

uniprot F1MBU9 153
type: UnificationXref
id: F1MBU9
db: uniprot

uniprot F7A403 53
type: UnificationXref
id: F7A403
db: uniprot

uniprot Q62077 131
type: UnificationXref
id: Q62077
db: uniprot

Rac family small GTPase 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q5U1Y2 251
organism: Rattus norvegicus

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 25

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: uniprot E9QAN8 152
xref: PTHR10048:SF30
organism: Mus musculus

uniprot F7H1Q7 223
type: UnificationXref
id: F7H1Q7
db: uniprot

uniprot H2QC90 61
type: UnificationXref
id: H2QC90
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q90694 235
xref: PTHR24072:SF136
organism: Gallus gallus

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 78

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 85
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0G2JTY4 86
type: UnificationXref
id: A0A0G2JTY4
db: uniprot

Uncoordinated 115a, isoform B
type: ProteinReference
xref: uniprot E1JIH3 82
organism: Drosophila melanogaster

uniprot F7HIS3 26
type: UnificationXref
id: F7HIS3
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_re27
control type: ACTIVATION
controller: Complex (Netrin/UNC-5/ DCC/UNC-40)

Ablim
type: ProteinReference
xref: P00358
standard name: Actin binding LIM protein 1
comment: ENTITY_REFERENCE_NOTES=Long Name: Actin binding LIM protein 1 Synonym: UNC-115 Accession: P00358
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.GENERIC.Ablim
member entity reference: Uncoordinated 115a, isoform B
member entity reference: ABLIM1 isoform 5
member entity reference: Uncharacterized protein
member entity reference: Actin-binding LIM protein 1

eco ECO:0000270 73
type: UnificationXref
id: ECO:0000270
db: eco

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 229

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 73

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 238

uniprot Q01112 228
type: UnificationXref
id: Q01112
db: uniprot

uniprot H2QNG6 179
type: UnificationXref
id: H2QNG6
db: uniprot

Cell division control protein 42
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot Q9HF56 237
organism: Ashbya gossypii

PTHR24072:SF281
type: RelationshipXref
id: PTHR24072:SF281
db: PANTHER Family
relationship type: By Homology

uniprot Q9JI33 76
type: UnificationXref
id: Q9JI33
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P26450 192
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7G3I5 172
xref: PTHR10048:SF107
organism: Monodelphis domestica

PANTHER Pathway P00009 1
type: UnificationXref
id: P00009
db: PANTHER Pathway

Netrin receptor UNC5C
type: ProteinReference
xref: uniprot Q7T2Z5 40
organism: Gallus gallus

Phosphoinositide-3-kinase regulatory subunit 2
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot H2QFS6 178
organism: Pan troglodytes

Netrin
type: Protein
entity reference: Netrin
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa3 263
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A8XWR5 12
type: UnificationXref
id: A8XWR5
db: uniprot

uniprot D4A0I8 91
type: UnificationXref
id: D4A0I8
db: uniprot

uniprot Q9Z1L0 212
type: UnificationXref
id: Q9Z1L0
db: uniprot

uniprot G7MIC2 59
type: UnificationXref
id: G7MIC2
db: uniprot

PTHR12533:SF6
type: RelationshipXref
id: PTHR12533:SF6
db: PANTHER Family
relationship type: By Homology

Netrin-4
type: ProteinReference
xref: PTHR10574:SF282
xref: uniprot Q9HB63 75
organism: Homo sapiens

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: uniprot O00443 182
xref: PTHR10048:SF28
organism: Homo sapiens

uniprot E1JIH3 82
type: UnificationXref
id: E1JIH3
db: uniprot

Netrin-3
type: ProteinReference
xref: uniprot Q9R1A3 79
organism: Mus musculus

ncbitaxon 9598 8
type: UnificationXref
id: 9598
db: ncbitaxon

PTHR12533:SF4
type: RelationshipXref
id: PTHR12533:SF4
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3T7A8 139
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

uniprot Q8CIH5 132
type: UnificationXref
id: Q8CIH5
db: uniprot

uniprot Q92569 209
type: UnificationXref
id: Q92569
db: uniprot

Netrin 3
type: ProteinReference
xref: uniprot E2R3Q6 51
organism: Canis lupus familiaris

uniprot E9GYE9 218
type: UnificationXref
id: E9GYE9
db: uniprot

PTHR24072:SF192
type: RelationshipXref
id: PTHR24072:SF192
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot F6VTR8 161
organism: Macaca mulatta

Netrin receptor UNC5C
type: ProteinReference
xref: uniprot O95185 33
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot H2QKD0 126
organism: Pan troglodytes

PI-3 kinase
type: ProteinReference
xref: uniprot P91634 199
xref: PTHR10048:SF14
organism: Drosophila melanogaster

uniprot F7BBM1 166
type: UnificationXref
id: F7BBM1
db: uniprot

PTHR24213:SF18
type: RelationshipXref
id: PTHR24213:SF18
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XSJ9 243
xref: PTHR24072:SF136
organism: Macaca mulatta

Phospholipase C
type: ProteinReference
xref: P00362
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.GENERIC.Phospholipase C
comment: ENTITY_REFERENCE_NOTES=Long Name: Phospholipase C Synonym: Phosphoinositide phospholipase C Accession: P00362
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

uniprot Q7K3H0 204
type: UnificationXref
id: Q7K3H0
db: uniprot

UNC 5 s11 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: UNC-5
stoichiometric coefficient: 1.0

uniprot A9JRY8 241
type: UnificationXref
id: A9JRY8
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 34

Phosphatidylinositol 3-kinase regulatory subunit beta
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot O00459 183
organism: Homo sapiens

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: uniprot Q92569 209
xref: PTHR10155:SF2
organism: Homo sapiens

uniprot D3ZTF6 144
type: UnificationXref
id: D3ZTF6
db: uniprot

UNC-5
type: Protein
entity reference: UNC-5
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa4 265
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P00361
type: UnificationXref
id: P00361
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__PI3K-RIGHT__PI3K-_re28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 281
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 282
left: PI3K
interaction type: STATE_TRANSITION
right: PI3K

P00362
type: UnificationXref
id: P00362
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Ablim-RIGHT__Ablim-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 277
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 278
left: Ablim
interaction type: STATE_TRANSITION
right: Ablim

P00360
type: UnificationXref
id: P00360
db: PANTHER Pathway Component

P00365
type: UnificationXref
id: P00365
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re29 279
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

P00366
type: UnificationXref
id: P00366
db: PANTHER Pathway Component

P00363
type: UnificationXref
id: P00363
db: PANTHER Pathway Component

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: uniprot Q14934 101
xref: PTHR12533:SF11
organism: Homo sapiens

P00364
type: UnificationXref
id: P00364
db: PANTHER Pathway Component

HETERODIMER_ASSOCIATION_LEFT__Netrin-_DCC_UNC_40-RIGHT__Complex__Netrin_DCC__UNC_40_-_r1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 295
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 297
left: Netrin
left: DCC/UNC-40
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Netrin/DCC/ UNC-40)

P00359
type: UnificationXref
id: P00359
db: PANTHER Pathway Component

P00358
type: UnificationXref
id: P00358
db: PANTHER Pathway Component

uniprot A0A3Q3ACS4 142
type: UnificationXref
id: A0A3Q3ACS4
db: uniprot

P00357
type: UnificationXref
id: P00357
db: PANTHER Pathway Component

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7GAP5 173
organism: Ornithorhynchus anatinus

P00356
type: UnificationXref
id: P00356
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re29 280
type: Stoichiometry
physical entity: NFAT
stoichiometric coefficient: 1.0

ncbitaxon 7955 66
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot A0A0G2K5T3 135
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

uniprot Q9HB63 75
type: UnificationXref
id: Q9HB63
db: uniprot

Netrin-4
type: ProteinReference
xref: PTHR10574:SF282
xref: uniprot F7A403 53
organism: Macaca mulatta

Unc-5 netrin receptor C
type: ProteinReference
xref: uniprot F1PUV2 22
organism: Canis lupus familiaris

Phospholipase C
type: Protein
entity reference: Phospholipase C
feature: ACTIVE 85
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
type: ProteinReference
xref: uniprot O00750 184
xref: PTHR10048:SF30
organism: Homo sapiens

Nuclear factor of activated T cells 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot F1MGR9 92
organism: Bos taurus

uniprot O00459 183
type: UnificationXref
id: O00459
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H1Q7 223
organism: Macaca mulatta

Nuclear factor of activated T-cells, cytoplasmic 3 isoform 2
type: ProteinReference
xref: uniprot F6RNN7 95
xref: PTHR12533:SF6
organism: Macaca mulatta

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

uniprot F6VTR8 161
type: UnificationXref
id: F6VTR8
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O00329 181
organism: Homo sapiens

uniprot K7DDW5 97
type: UnificationXref
id: K7DDW5
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 66

PARTICIPANT STOICHIOMETRY r17 274
type: Stoichiometry
physical entity: Netrin
stoichiometric coefficient: 1.0

uniprot O14639 84
type: UnificationXref
id: O14639
db: uniprot

PARTICIPANT STOICHIOMETRY r17 275
type: Stoichiometry
physical entity: UNC-5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r17 276
type: Stoichiometry
physical entity: Complex (UNC-5/Netrin)
stoichiometric coefficient: 1.0

uniprot F6QM53 157
type: UnificationXref
id: F6QM53
db: uniprot

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Ablim

UNC-5
type: Protein
entity reference: UNC-5
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa6 269
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Y2I2 80
type: UnificationXref
id: Q9Y2I2
db: uniprot

uniprot E2RPB0 151
type: UnificationXref
id: E2RPB0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot A0A3Q3ACS4 142
organism: Gallus gallus

ncbitaxon 9258 158
type: UnificationXref
id: 9258
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot G7MIC2 59
organism: Macaca mulatta

uniprot Q8IZJ1 42
type: UnificationXref
id: Q8IZJ1
db: uniprot

Netrin G2
type: ProteinReference
xref: uniprot A0A2I3SSG9 46
organism: Pan troglodytes

uniprot F7HLC7 174
type: UnificationXref
id: F7HLC7
db: uniprot

uniprot A0A2I3SIY1 138
type: UnificationXref
id: A0A2I3SIY1
db: uniprot

uniprot P40793 224
type: UnificationXref
id: P40793
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QIU6 3
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3S5ZPV2 112
organism: Gallus gallus

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

Netrin
type: Protein
entity reference: Netrin
comment: SPECIES_TYPE=PROTEIN

uniprot Q8K1S4 45
type: UnificationXref
id: Q8K1S4
db: uniprot

DCC/UNC-40
type: Protein
entity reference: DCC/UNC-40
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa2 261
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ACTIVE 85
type: EntityFeature
comment: Active state

uniprot P42336 195
type: UnificationXref
id: P42336
db: uniprot

uniprot O00329 181
type: UnificationXref
id: O00329
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot D4A5Q1 146
organism: Rattus norvegicus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: MAX-1

uniprot O08747 31
type: UnificationXref
id: O08747
db: uniprot

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: uniprot P50551 114
organism: Canis lupus familiaris

ncbitaxon 7227 69
type: UnificationXref
id: 7227
db: ncbitaxon

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: uniprot P50552 115
organism: Homo sapiens

uniprot F6U702 113
type: UnificationXref
id: F6U702
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot P16885 129
xref: PTHR10336:SF25
organism: Homo sapiens

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

IDA
type: EvidenceCodeVocabulary

Rac
type: Protein
entity reference: Rac
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 6239 36
type: UnificationXref
id: 6239
db: ncbitaxon

cdc42
type: ProteinReference
xref: P00364
standard name: Cell division cycle 42
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.GENERIC.cdc42
comment: ENTITY_REFERENCE_NOTES=Long Name: Cell division cycle 42 Synonym: G25K,GTP binding protein, 25K Accession: P00364
member entity reference: Cell division control protein 42 homolog
member entity reference: Ras homolog family member U
member entity reference: Cdc42 homolog
member entity reference: Uncharacterized protein
member entity reference: Cdc42 protein, putative
member entity reference: Cell division control protein 42
member entity reference: Cell division cycle 42
member entity reference: Cell division control protein 42 homolog isoform 2
member entity reference: Rho-related GTP-binding protein RhoU

ENAH, actin regulator
type: ProteinReference
xref: uniprot A0A0G2K6I4 110
organism: Rattus norvegicus

uniprot F7G4D6 57
type: UnificationXref
id: F7G4D6
db: uniprot

uniprot F1MHX0 20
type: UnificationXref
id: F1MHX0
db: uniprot

PTHR12533:SF11
type: RelationshipXref
id: PTHR12533:SF11
db: PANTHER Family
relationship type: By Homology

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q05144 249
organism: Mus musculus

Rac family small GTPase 1
type: ProteinReference
xref: uniprot Q6GL60 253
xref: PTHR24072:SF105
organism: Xenopus tropicalis

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

uniprot H2QAD5 60
type: UnificationXref
id: H2QAD5
db: uniprot

uniprot P43146 107
type: UnificationXref
id: P43146
db: uniprot

Nuclear factor of activated T-cells, cytoplasmic 4
type: ProteinReference
xref: uniprot D3Z9H7 90
xref: PTHR12533:SF11
organism: Rattus norvegicus

Netrin-4
type: ProteinReference
xref: PTHR10574:SF282
xref: uniprot Q9JI33 76
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MYM3 154
xref: PTHR10048:SF33
organism: Bos taurus

ncbitaxon 6945 215
type: UnificationXref
id: 6945
db: ncbitaxon

Netrin 4
type: ProteinReference
xref: PTHR10574:SF282
xref: uniprot K7C5Y1 62
organism: Pan troglodytes

DCC UNC 40 s4 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DCC/UNC-40
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P10686 128
organism: Rattus norvegicus

ncbitaxon 7739 217
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot Q24568 70
type: UnificationXref
id: Q24568
db: uniprot

uniprot Q8K1S2 43
type: UnificationXref
id: Q8K1S2
db: uniprot

uniprot F1MGR9 92
type: UnificationXref
id: F1MGR9
db: uniprot

By Homology
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QQJ4 5
organism: Macaca mulatta

uniprot F1MSU2 93
type: UnificationXref
id: F1MSU2
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A1D5QLW6 118
xref: PTHR10336:SF25
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot A0A1D5QLW3 87
organism: Macaca mulatta

uniprot P10686 128
type: UnificationXref
id: P10686
db: uniprot

PTHR10048:SF64
type: RelationshipXref
id: PTHR10048:SF64
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_re27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 283
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 284
left: Rac
interaction type: STATE_TRANSITION
right: Rac

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 19

uniprot F6RBZ7 220
type: UnificationXref
id: F6RBZ7
db: uniprot

uniprot Q6LC82 254
type: UnificationXref
id: Q6LC82
db: uniprot

Nuclear factor of activated T cells 2
type: ProteinReference
xref: PTHR12533:SF4
xref: uniprot H2R4F5 96
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re28 282
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

uniprot A0A3S5ZPV2 112
type: UnificationXref
id: A0A3S5ZPV2
db: uniprot

uniprot Q52WY2 232
type: UnificationXref
id: Q52WY2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QS85 6
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re28 281
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

PTHR22903:SF8
type: RelationshipXref
id: PTHR22903:SF8
db: PANTHER Family
relationship type: By Homology

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 219

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M623 49
organism: Bos taurus

STATE_TRANSITION_LEFT__Ena-RIGHT__Ena-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 293
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 294
left: Ena
interaction type: STATE_TRANSITION
right: Ena

uniprot O70173 189
type: UnificationXref
id: O70173
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QJY6 136
xref: PTHR10048:SF28
organism: Macaca mulatta

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: uniprot Q61194 200
xref: PTHR10048:SF28
organism: Mus musculus

uniprot P27986 193
type: UnificationXref
id: P27986
db: uniprot

uniprot E2RQM0 122
type: UnificationXref
id: E2RQM0
db: uniprot

uniprot H2QKD0 126
type: UnificationXref
id: H2QKD0
db: uniprot

Phosphoinositide 3-kinase regulatory subunit 5
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot Q8WYR1 208
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__cdc42-RIGHT__cdc42-_re26
control type: ACTIVATION
controller: Complex (Netrin/DCC/ UNC-40)

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re25 292
type: Stoichiometry
physical entity: MAX-1
stoichiometric coefficient: 1.0

uniprot O35904 186
type: UnificationXref
id: O35904
db: uniprot

PARTICIPANT STOICHIOMETRY re25 291
type: Stoichiometry
physical entity: MAX-1
stoichiometric coefficient: 1.0

uniprot A0A2I3SHP7 120
type: UnificationXref
id: A0A2I3SHP7
db: uniprot

PARTICIPANT STOICHIOMETRY re26 289
type: Stoichiometry
physical entity: cdc42
stoichiometric coefficient: 1.0

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q9VXH3 133
organism: Drosophila melanogaster

uniprot F6RNN7 95
type: UnificationXref
id: F6RNN7
db: uniprot

uniprot F6RRI0 105
type: UnificationXref
id: F6RRI0
db: uniprot

uniprot E2RH85 149
type: UnificationXref
id: E2RH85
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7HLC7 174
xref: PTHR10048:SF35
organism: Macaca mulatta

uniprot E1BE66 147
type: UnificationXref
id: E1BE66
db: uniprot

uniprot P15153 245
type: UnificationXref
id: P15153
db: uniprot

uniprot Q9NL28 77
type: UnificationXref
id: Q9NL28
db: uniprot

uniprot F6Y381 221
type: UnificationXref
id: F6Y381
db: uniprot

uniprot A5PJP9 11
type: UnificationXref
id: A5PJP9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR12533:SF6
xref: uniprot F1MSU2 93
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re26 290
type: Stoichiometry
physical entity: cdc42
stoichiometric coefficient: 1.0

ncbitaxon 9615 17
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot A0A2I3SSG9 46
type: UnificationXref
id: A0A2I3SSG9
db: uniprot

LD28067p
type: ProteinReference
xref: uniprot Q7K3H0 204
xref: PTHR10048:SF64
organism: Drosophila melanogaster

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F1PS03 123
organism: Canis lupus familiaris

STATE_TRANSITION
type: InteractionVocabulary

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10155:SF1
xref: uniprot E2RH85 149
organism: Canis lupus familiaris

NFAT
type: Protein
entity reference: NFAT
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A567 222
xref: PTHR24072:SF136
organism: Monodelphis domestica

Netrin s13 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Netrin
stoichiometric coefficient: 1.0

uniprot Q9EQT3 236
type: UnificationXref
id: Q9EQT3
db: uniprot

Cdc42 homolog
type: ProteinReference
xref: uniprot Q17031 230
xref: PTHR24072:SF192
organism: Anopheles gambiae

Netrin 3
type: ProteinReference
xref: uniprot A0A3Q1LQK7 48
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 134
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot A0A2J8QY32 141
type: UnificationXref
id: A0A2J8QY32
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: PI3K

Netrin-G1
type: ProteinReference
xref: uniprot Q9Y2I2 80
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot Q8CIH5 132
xref: PTHR10336:SF25
organism: Mus musculus

uniprot F7G3I5 172
type: UnificationXref
id: F7G3I5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6U702 113
organism: Macaca mulatta

Cdc42 protein, putative
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot B7PHY7 214
organism: Ixodes scapularis

BOOLEAN_LOGIC_GATE_OR
type: Control
xref: BOOLEAN LOGIC GATE OR
controlled: STATE_TRANSITION_LEFT__cdc42-RIGHT__cdc42-_re26

uniprot P48736 198
type: UnificationXref
id: P48736
db: uniprot

transcription
type: Pathway

uniprot O08908 185
type: UnificationXref
id: O08908
db: uniprot

go GO:0005829 2
type: UnificationXref
id: GO:0005829
db: go

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: uniprot A0A0G2K9C0 111
organism: Rattus norvegicus

uniprot A0A2I3TJ60 89
type: UnificationXref
id: A0A2I3TJ60
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1Q3M8 156
xref: PTHR10048:SF107
organism: Canis lupus familiaris

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot H2QNG6 179
xref: PTHR10048:SF33
organism: Pan troglodytes

Protein CBR-MAX-1
type: ProteinReference
xref: PTHR22903:SF8
xref: uniprot A8X936 239
organism: Caenorhabditis briggsae

Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot F7BZL6 167
organism: Macaca mulatta

uniprot F1PAZ4 104
type: UnificationXref
id: F1PAZ4
db: uniprot

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

uniprot C3ZIB9 216
type: UnificationXref
id: C3ZIB9
db: uniprot

uniprot D3Z9H7 90
type: UnificationXref
id: D3Z9H7
db: uniprot

uniprot F1MYM3 154
type: UnificationXref
id: F1MYM3
db: uniprot

uniprot Q6DGB7 252
type: UnificationXref
id: Q6DGB7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H9FVU5 180
xref: PTHR10048:SF107
organism: Macaca mulatta

uniprot Q28BZ0 231
type: UnificationXref
id: Q28BZ0
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit gamma
type: ProteinReference
xref: PTHR10155:SF2
xref: uniprot O46404 187
organism: Bos taurus

uniprot F1LW30 18
type: UnificationXref
id: F1LW30
db: uniprot

ncbitaxon 6238 13
type: UnificationXref
id: 6238
db: ncbitaxon

ncbitaxon 9913 10
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot Q6GL60 253
type: UnificationXref
id: Q6GL60
db: uniprot

Rac family small GTPase 3b
type: ProteinReference
xref: uniprot A9JRY8 241
xref: PTHR24072:SF301
organism: Danio rerio

uniprot P91634 199
type: UnificationXref
id: P91634
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot C3ZIB9 216
organism: Branchiostoma floridae

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Ablim
type: Protein
entity reference: Ablim
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR44170:SF8
type: RelationshipXref
id: PTHR44170:SF8
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF29
type: RelationshipXref
id: PTHR10048:SF29
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF28
type: RelationshipXref
id: PTHR10048:SF28
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ena-RIGHT__Ena-_r2
controller: Complex (Netrin/DCC/ UNC-40)

PARTICIPANT STOICHIOMETRY r4 288
type: Stoichiometry
physical entity: Complex (Netrin/UNC-5/ DCC/UNC-40)
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: transcription
controller: NFAT

PARTICIPANT STOICHIOMETRY r4 287
type: Stoichiometry
physical entity: DCC/UNC-40
stoichiometric coefficient: 1.0

Unc-5 netrin receptor D
type: ProteinReference
xref: uniprot F1Q2N1 23
organism: Canis lupus familiaris

PIK3CG isoform 1
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot A0A2J8QY32 141
organism: Pan troglodytes

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 143
organism: Rattus norvegicus

PTHR10048:SF30
type: RelationshipXref
id: PTHR10048:SF30
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F6Y841 164
organism: Canis lupus familiaris

uniprot Q64143 203
type: UnificationXref
id: Q64143
db: uniprot

PARTICIPANT STOICHIOMETRY r4 286
type: Stoichiometry
physical entity: UNC-5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 285
type: Stoichiometry
physical entity: Netrin
stoichiometric coefficient: 1.0

NFAT
type: ProteinReference
xref: P00359
standard name: Nuclear factor of activated T-cells
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by netrin.PROTEIN.GENERIC.NFAT
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Nuclear factor of activated T-cells Synonym: Nuclear factor of activated T-cells Accession: P00359
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 3
member entity reference: Nuclear factor of activated T cells 2
member entity reference: Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (Predicted), isoform CRA_b
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 2
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 4
member entity reference: NFATC3 isoform 2
member entity reference: NFATC4 isoform 9
member entity reference: Uncharacterized protein
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 3 isoform 2
member entity reference: Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (Predicted), isoform CRA_b

ncbitaxon 9606 34
type: UnificationXref
id: 9606
db: ncbitaxon

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot A0A1D5R8E9 119
organism: Macaca mulatta

uniprot Q761X5 39
type: UnificationXref
id: Q761X5
db: uniprot

NTN3 isoform 1
type: ProteinReference
xref: uniprot H2QAD5 60
organism: Pan troglodytes

STATE_TRANSITION_LEFT__NFAT-RIGHT__NFAT-_re29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 279
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 280
left: NFAT
interaction type: STATE_TRANSITION
right: NFAT