Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P62999 138
xref: PTHR24072:SF105
organism: Canis lupus familiaris

uniprot Q16555 128
type: UnificationXref
id: Q16555
db: uniprot

Evidence 108
type: Evidence
evidence code: ISS
comment: SPACC Q90635

Uncharacterized protein
type: ProteinReference
evidence: Evidence 108
xref: uniprot A0A1D5QW32 107
xref: PTHR11647:SF56
organism: Macaca mulatta

CRAM
type: ProteinReference
xref: P00330
standard name: CRMP 3-associated molecule
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.CRAM
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dihydropyrimidinase like 5
member entity reference: DPYSL5 protein
member entity reference: Dihydropyrimidinase-related protein 5

uniprot H2Q2S9 118
type: UnificationXref
id: H2Q2S9
db: uniprot

uniprot Q9BPU6 31
type: UnificationXref
id: Q9BPU6
db: uniprot

uniprot E1B7F6 3
type: UnificationXref
id: E1B7F6
db: uniprot

uniprot F7HHM6 101
type: UnificationXref
id: F7HHM6
db: uniprot

uniprot O14531 122
type: UnificationXref
id: O14531
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_re13
controller: Complex (Sema4D/plexinB1/ RhoGEF)

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63001 140
organism: Mus musculus

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63000 139
xref: PTHR24072:SF105
organism: Homo sapiens

Plexin-A1
type: ProteinReference
xref: uniprot Q9UIW2 59
xref: PTHR22625:SF35
organism: Homo sapiens

Mus musculus
type: BioSource
xref: ncbitaxon 10090 19

Sema3A s7 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Sema3A
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6U213 7
organism: Macaca mulatta

CRAM
type: Protein
entity reference: CRAM
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa9 163
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 80

RhoGEF
type: Protein
entity reference: RhoGEF
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa15 169
feature: ACTIVE 13
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Sema4D
type: Protein
entity reference: Sema4D
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa10 171
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF325
xref: uniprot F7GY91 136
organism: Macaca mulatta

uniprot F1MEW1 88
type: UnificationXref
id: F1MEW1
db: uniprot

Tyrosine-protein kinase FRK
type: ProteinReference
xref: uniprot P42685 73
organism: Homo sapiens

eco ECO:0000270 32
type: UnificationXref
id: ECO:0000270
db: eco

Dihydropyrimidinase-related protein 1
type: ProteinReference
xref: PTHR11647:SF54
xref: uniprot Q62950 129
organism: Rattus norvegicus

uniprot E2RC09 62
type: UnificationXref
id: E2RC09
db: uniprot

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

uniprot Q62950 129
type: UnificationXref
id: Q62950
db: uniprot

PlexinA1 s9 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PlexinA1
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 108
xref: PTHR11647:SF56
xref: uniprot F7DMI7 116
organism: Monodelphis domestica

PlexinA1
type: ProteinReference
xref: P00334
standard name: Plexin A1
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.RECEPTOR.PlexinA1
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Plexin A1
member entity reference: Uncharacterized protein
member entity reference: Plexin-A1

uniprot Q9QWJ9 106
type: UnificationXref
id: Q9QWJ9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NNK9 113
organism: Gallus gallus

uniprot F7GY91 136
type: UnificationXref
id: F7GY91
db: uniprot

Dihydropyrimidinase-related protein 4
type: ProteinReference
xref: uniprot O14531 122
organism: Homo sapiens

uniprot P16879 48
type: UnificationXref
id: P16879
db: uniprot

uniprot P42685 73
type: UnificationXref
id: P42685
db: uniprot

uniprot P97427 125
type: UnificationXref
id: P97427
db: uniprot

uniprot Q5U1Y2 143
type: UnificationXref
id: Q5U1Y2
db: uniprot

uniprot H2QML4 152
type: UnificationXref
id: H2QML4
db: uniprot

Tyrosine-protein kinase fynb
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F1RDG9 63
organism: Danio rerio

Axon guidance mediated by semaphorins
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Complex__CRAM_CRMP_-_ATP-RIGHT__Complex__CRMP_CRAM_-_ADP-_r9
pathway component: STATE_TRANSITION_LEFT__Fes-RIGHT__Fes-_r8
pathway component: PHYSICAL_STIMULATION
pathway component: HETERODIMER_ASSOCIATION_LEFT__RhoGEF-_Sema4D-_plexinB1-RIGHT__Complex__Sema4D_plexinB1__RhoGEF_-_r20
pathway component: STATE_TRANSITION_LEFT__Cdk5-_ATP-RIGHT__ADP-_Cdk5-_r4
pathway component: STATE_TRANSITION_LEFT__Fyn-RIGHT__Fyn-_r5
pathway component: HETERODIMER_ASSOCIATION_LEFT__Sema3A-_Complex__PlexinA1_Neuropilin_1_-RIGHT__Complex__Sema3A_Neuropilin_1__PlexinA1_-_r2
pathway component: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_re13
pathway component: HETERODIMER_ASSOCIATION_LEFT__Sema4D-_plexinB1-_Rac-RIGHT__Complex__Sema4D_plexinB1__Rac_-_r23
pathway component: STATE_TRANSITION_LEFT__Pak-_ATP-RIGHT__Pak-_ADP-_r3
xref: PANTHER Pathway P00007 1
comment: MODEL_NOTES=Panther Pathway: P00007 This pathway describes axon growth cone collapse induced by semaphorin 3A and semaphorin 4D. Medline=12677003 Medline=14682358 Medline=14687984 PMID: 12677003 PMID: 14682358 PMID: 14687984

uniprot D4A584 44
type: UnificationXref
id: D4A584
db: uniprot

ARHGEF1 isoform 4
type: ProteinReference
xref: PTHR45872:SF4
xref: uniprot H2QGF2 50
organism: Pan troglodytes

ncbitaxon 10116 15
type: UnificationXref
id: 10116
db: ncbitaxon

Neuropilin-1
type: ProteinReference
xref: PTHR46806:SF4
xref: uniprot Q9QWJ9 106
organism: Rattus norvegicus

Rho
type: Protein
entity reference: Rho
feature: ACTIVE 13
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Cyclin-dependent kinase 5
type: ProteinReference
xref: uniprot Q9DE44 85
organism: Danio rerio

uniprot O08665 93
type: UnificationXref
id: O08665
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F7FG65 68
organism: Monodelphis domestica

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7G2C9 69
organism: Macaca mulatta

Neuropilin 1
type: Protein
entity reference: Neuropilin 1
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa4 179
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 67

uniprot O88643 39
type: UnificationXref
id: O88643
db: uniprot

Neuropilin-1
type: ProteinReference
xref: PTHR46806:SF4
xref: uniprot O14786 103
organism: Homo sapiens

Dihydropyrimidinase-related protein 1
type: ProteinReference
xref: PTHR11647:SF54
xref: uniprot P97427 125
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r9 213
type: Stoichiometry
physical entity: Complex (CRMP/CRAM)
stoichiometric coefficient: 1.0

uniprot P47942 124
type: UnificationXref
id: P47942
db: uniprot

Dihydropyrimidinase
type: ProteinReference
xref: uniprot Q63150 130
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r9 214
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 211
type: Stoichiometry
physical entity: Complex (CRAM/CRMP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 212
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot P07332 47
type: UnificationXref
id: P07332
db: uniprot

Rac
type: Protein
entity reference: Rac
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa12 175
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O93467 153
type: UnificationXref
id: O93467
db: uniprot

uniprot P48609 79
type: UnificationXref
id: P48609
db: uniprot

Rac family small GTPase 3a
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot Q6DGB7 144
organism: Danio rerio

Dihydropyrimidinase-related protein 5
type: ProteinReference
xref: uniprot F6XU97 25
xref: PTHR11647:SF58
organism: Macaca mulatta

uniprot Q63150 130
type: UnificationXref
id: Q63150
db: uniprot

uniprot H2R8X1 30
type: UnificationXref
id: H2R8X1
db: uniprot

uniprot P97333 104
type: UnificationXref
id: P97333
db: uniprot

SEMA3A isoform 1
type: ProteinReference
xref: uniprot H2QUV1 92
organism: Pan troglodytes

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P70206 58
type: UnificationXref
id: P70206
db: uniprot

Transforming protein RhoA
type: ProteinReference
xref: uniprot P61585 154
xref: PTHR24072:SF153
organism: Bos taurus

Transforming protein RhoA
type: ProteinReference
xref: uniprot P61586 155
xref: PTHR24072:SF153
organism: Homo sapiens

uniprot Q61210 51
type: UnificationXref
id: Q61210
db: uniprot

DPYSL2 isoform 2
type: ProteinReference
evidence: Evidence 108
xref: PTHR11647:SF56
xref: uniprot K6ZQM1 119
organism: Pan troglodytes

PTHR45872:SF4
type: RelationshipXref
id: PTHR45872:SF4
db: PANTHER Family
relationship type: By Homology

uniprot Q05144 141
type: UnificationXref
id: Q05144
db: uniprot

PlexinA1
type: Protein
entity reference: PlexinA1
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa5 181
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Cdk5
type: ProteinReference
xref: P00336
standard name: Cyclin-dependent kinase 5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.Cdk5
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclin-dependent kinase 5 Synonym: Cell division kinase 5,PSSALRE Accession: P00336
member entity reference: Uncharacterized protein
member entity reference: Cyclin-dependent-like kinase 5
member entity reference: Cyclin-dependent kinase 5 homolog
member entity reference: Cyclin-dependent kinase 5
member entity reference: Cyclin dependent kinase 5

uniprot A8E641 21
type: UnificationXref
id: A8E641
db: uniprot

uniprot F6XUP1 38
type: UnificationXref
id: F6XUP1
db: uniprot

ncbitaxon 10090 19
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot F1PK01 24
type: UnificationXref
id: F1PK01
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QEV2 77
xref: PTHR24056:SF46
organism: Macaca mulatta

uniprot F1Q088 114
type: UnificationXref
id: F1Q088
db: uniprot

Novel Rho protein
type: ProteinReference
xref: uniprot Q28HZ4 157
organism: Xenopus tropicalis

Fes
type: Protein
entity reference: Fes
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 8364 67
type: UnificationXref
id: 8364
db: ncbitaxon

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot Q5E9H3 49
organism: Bos taurus

uniprot E1BER6 111
type: UnificationXref
id: E1BER6
db: uniprot

uniprot F1NNK9 113
type: UnificationXref
id: F1NNK9
db: uniprot

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot O88643 39
organism: Mus musculus

uniprot F6XF66 90
type: UnificationXref
id: F6XF66
db: uniprot

Dihydropyrimidinase-related protein 2
type: ProteinReference
evidence: Evidence 108
xref: uniprot O02675 120
xref: PTHR11647:SF56
organism: Bos taurus

Sema4D
type: Protein
entity reference: Sema4D
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa13 165
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9QUI0 159
type: UnificationXref
id: Q9QUI0
db: uniprot

Fyn
type: ProteinReference
xref: P00335
standard name: Fyn tyrosine kinase protooncogene
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Fyn tyrosine kinase protooncogene Synonym: FYN oncogene related to Src, FGR, YES,SYN Accession: P00335
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.Fyn
member entity reference: Tyrosine-protein kinase Fyn
member entity reference: Tyrosine-protein kinase FRK
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase fyna
member entity reference: Tyrosine-protein kinase fynb

uniprot E2QX94 87
type: UnificationXref
id: E2QX94
db: uniprot

uniprot Q03114 84
type: UnificationXref
id: Q03114
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot E1C3P6 35
organism: Gallus gallus

Neuropilin
type: ProteinReference
xref: uniprot A0A1L1RW02 97
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r2 205
type: Stoichiometry
physical entity: Complex (PlexinA1/Neuropilin 1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 206
type: Stoichiometry
physical entity: Complex (Sema3A/Neuropilin 1/ PlexinA1)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Q9V8 89
xref: PTHR11036:SF23
organism: Monodelphis domestica

uniprot Q7ZSZ9 148
type: UnificationXref
id: Q7ZSZ9
db: uniprot

PARTICIPANT STOICHIOMETRY r2 204
type: Stoichiometry
physical entity: Sema3A
stoichiometric coefficient: 1.0

CRAM s13 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRAM
stoichiometric coefficient: 1.0

DPYSL5 protein
type: ProteinReference
xref: uniprot A8E641 21
xref: PTHR11647:SF58
organism: Bos taurus

PTHR24056:SF46
type: RelationshipXref
id: PTHR24056:SF46
db: PANTHER Family
relationship type: By Homology

Dihydropyrimidinase-related protein 5
type: ProteinReference
xref: uniprot Q9BPU6 31
xref: PTHR11647:SF58
organism: Homo sapiens

uniprot P35465 41
type: UnificationXref
id: P35465
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

go GO:0005829 2
type: UnificationXref
id: GO:0005829
db: go

Bos taurus
type: BioSource
xref: ncbitaxon 9913 4

HETERODIMER_ASSOCIATION_LEFT__RhoGEF-_Sema4D-_plexinB1-RIGHT__Complex__Sema4D_plexinB1__RhoGEF_-_r20
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 208
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 210
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 209
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 207
left: Sema4D
left: plexinB1
left: RhoGEF
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Sema4D/plexinB1/ RhoGEF)

uniprot Q14194 127
type: UnificationXref
id: Q14194
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 8

DPYSL4 isoform 1
type: ProteinReference
xref: uniprot H2Q2S9 118
organism: Pan troglodytes

00696
type: UnificationXref
id: MOD:00696
db: mod

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 29

uniprot O14786 103
type: UnificationXref
id: O14786
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q9TU25 149
xref: PTHR24072:SF169
organism: Bos taurus

Fes
type: Protein
entity reference: Fes
feature: ACTIVE 13
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dihydropyrimidinase like 5
type: ProteinReference
xref: uniprot F6ZT50 26
xref: PTHR11647:SF58
organism: Monodelphis domestica

uniprot F7G2C9 69
type: UnificationXref
id: F7G2C9
db: uniprot

Neuropilin-1
type: ProteinReference
xref: uniprot P97333 104
xref: PTHR46806:SF4
organism: Mus musculus

uniprot F7DKD5 115
type: UnificationXref
id: F7DKD5
db: uniprot

uniprot F7DMI7 116
type: UnificationXref
id: F7DMI7
db: uniprot

uniprot F6XSJ9 135
type: UnificationXref
id: F6XSJ9
db: uniprot

uniprot H2Q1T2 102
type: UnificationXref
id: H2Q1T2
db: uniprot

Rac s16 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

uniprot A0A2I3SKP4 60
type: UnificationXref
id: A0A2I3SKP4
db: uniprot

Neuropilin
type: ProteinReference
xref: PTHR46806:SF4
xref: uniprot F7HHM6 101
organism: Macaca mulatta

uniprot P15153 137
type: UnificationXref
id: P15153
db: uniprot

cytosol
type: CellularLocationVocabulary
xref: go GO:0005829 2

Dihydropyrimidinase-related protein 2
type: ProteinReference
evidence: Evidence 108
xref: uniprot P47942 124
xref: PTHR11647:SF56
organism: Rattus norvegicus

PlexinA1
type: Protein
entity reference: PlexinA1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 183
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MEW1 88
xref: PTHR11036:SF23
organism: Bos taurus

Semaphorin 3A
type: ProteinReference
xref: uniprot F7AVR4 91
xref: PTHR11036:SF23
organism: Ornithorhynchus anatinus

uniprot Q9EQF5 133
type: UnificationXref
id: Q9EQF5
db: uniprot

Plexin A1
type: ProteinReference
xref: PTHR22625:SF35
xref: uniprot D3Z981 55
organism: Rattus norvegicus

Rho-related GTP-binding protein RhoA-B
type: ProteinReference
xref: uniprot Q6DHM9 158
organism: Danio rerio

uniprot Q62844 75
type: UnificationXref
id: Q62844
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11647:SF54
xref: uniprot E1BER6 111
organism: Bos taurus

uniprot Q6GL60 145
type: UnificationXref
id: Q6GL60
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 6

uniprot E2RM56 5
type: UnificationXref
id: E2RM56
db: uniprot

Dihydropyrimidinase like 4
type: ProteinReference
xref: uniprot F1Q088 114
organism: Canis lupus familiaris

GTPase cRac1A
type: ProteinReference
xref: uniprot Q6LC82 146
xref: PTHR24072:SF105
organism: Gallus gallus

Semaphorin 3A
type: ProteinReference
xref: uniprot F6XF66 90
organism: Xenopus tropicalis

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot H2QTL3 70
organism: Pan troglodytes

Sema4D s21 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Sema4D
stoichiometric coefficient: 1.0

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot E2RC09 62
organism: Canis lupus familiaris

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot Q08E52 42
organism: Bos taurus

RhoGEF
type: ProteinReference
xref: P00333
standard name: Rho guanine nucleotide exchange factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.RhoGEF
comment: ENTITY_REFERENCE_NOTES=Long Name: Rho guanine nucleotide exchange factor Synonym: Guanine nucleotide exchange factor, 115KD,p115-RhoGEF Accession: P00333
member entity reference: ARHGEF1 isoform 4
member entity reference: Rho guanine nucleotide exchange factor 1

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 36

Complex (PlexinA1/Neuropilin 1)
type: Complex
component stoichiometry: Neuropilin 1 s2 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: PlexinA1 s1 sa1 STOICHIOMETRY ID COMPLEX
component: Neuropilin 1
component: PlexinA1
feature: COMPLEX BINDING FEATURE s3 a3 182
feature: COMPLEX BINDING FEATURE s3 a3 184
cellular location: cytosol

Sema4D
type: Protein
entity reference: Sema4D
comment: SPECIES_TYPE=PROTEIN

uniprot A2VDS7 110
type: UnificationXref
id: A2VDS7
db: uniprot

Cyclin-dependent-like kinase 5
type: ProteinReference
xref: uniprot Q03114 84
organism: Rattus norvegicus

uniprot H2QTL3 70
type: UnificationXref
id: H2QTL3
db: uniprot

Neuropilin
type: ProteinReference
xref: PTHR46806:SF4
xref: uniprot H2Q1T2 102
organism: Pan troglodytes

PTHR46806:SF4
type: RelationshipXref
id: PTHR46806:SF4
db: PANTHER Family
relationship type: By Homology

Rac family small GTPase 1a
type: ProteinReference
xref: uniprot Q7ZSZ9 148
xref: PTHR24072:SF105
organism: Danio rerio

ncbitaxon 9913 4
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot Q9DE44 85
type: UnificationXref
id: Q9DE44
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pak-_ATP-RIGHT__Pak-_ADP-_r3
controller: Cdk5

uniprot P62999 138
type: UnificationXref
id: P62999
db: uniprot

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot Q62844 75
organism: Rattus norvegicus

Cyclin-dependent-like kinase 5
type: ProteinReference
xref: uniprot Q02399 83
organism: Bos taurus

STATE_TRANSITION
type: RelationshipTypeVocabulary

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot E2REH3 37
type: UnificationXref
id: E2REH3
db: uniprot

Dihydropyrimidinase like 5
type: ProteinReference
xref: PTHR11647:SF58
xref: uniprot F7CVF2 28
organism: Ornithorhynchus anatinus

STATE_TRANSITION_LEFT__Cdk5-_ATP-RIGHT__ADP-_Cdk5-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 193
left: ATP
left: Cdk5
interaction type: STATE_TRANSITION
right: ADP
right: Cdk5

uniprot Q6RUV5 147
type: UnificationXref
id: Q6RUV5
db: uniprot

uniprot F6XU97 25
type: UnificationXref
id: F6XU97
db: uniprot

Pak
type: ProteinReference
xref: P00331
standard name: p21-activated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.Pak
comment: ENTITY_REFERENCE_NOTES=Long Name: p21-activated kinase Synonym: Synonym not specified Accession: P00331
member entity reference: Serine/threonine-protein kinase PAK 1
member entity reference: Non-specific serine/threonine protein kinase

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot H2QA35 46
organism: Pan troglodytes

HETERODIMER_ASSOCIATION_LEFT__Sema4D-_plexinB1-_Rac-RIGHT__Complex__Sema4D_plexinB1__Rac_-_r23
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 202
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 200
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 201
left: Sema4D
left: Rac
left: plexinB1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Sema4D/plexinB1/ Rac)

uniprot F7CS91 151
type: UnificationXref
id: F7CS91
db: uniprot

uniprot Q9UIW2 59
type: UnificationXref
id: Q9UIW2
db: uniprot

PTHR11036:SF23
type: RelationshipXref
id: PTHR11036:SF23
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r20 210
type: Stoichiometry
physical entity: Complex (Sema4D/plexinB1/ RhoGEF)
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot E2REH3 37
organism: Canis lupus familiaris

uniprot Q14563 94
type: UnificationXref
id: Q14563
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6RUV5 147
organism: Rattus norvegicus

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot P15153 137
organism: Homo sapiens

uniprot F6Q9V8 89
type: UnificationXref
id: F6Q9V8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11647:SF54
xref: uniprot F7DKD5 115
organism: Macaca mulatta

Dihydropyrimidinase-related protein 4
type: ProteinReference
xref: uniprot F1LNT0 112
organism: Rattus norvegicus

Plexin-A1
type: ProteinReference
xref: PTHR22625:SF35
xref: uniprot P70206 58
organism: Mus musculus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_re13
control type: ACTIVATION
controller: Complex (Sema3A/Neuropilin 1/ PlexinA1)

Complex (Sema4D/plexinB1/ RhoGEF)
type: Complex
component stoichiometry: Sema4D s21 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: plexinB1 s22 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: RhoGEF s23 sa15 STOICHIOMETRY ID COMPLEX
component: RhoGEF
component: Sema4D
component: plexinB1
feature: COMPLEX BINDING FEATURE s58 a68 166
feature: COMPLEX BINDING FEATURE s58 a68 164
feature: COMPLEX BINDING FEATURE s58 a68 168
cellular location: cytosol

Plexin A1
type: ProteinReference
xref: PTHR22625:SF35
xref: uniprot E1BFR4 56
organism: Bos taurus

CRMP s11 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRMP
stoichiometric coefficient: 1.0

uniprot A0A1D5QW32 107
type: UnificationXref
id: A0A1D5QW32
db: uniprot

ncbitaxon 7955 64
type: UnificationXref
id: 7955
db: ncbitaxon

Cdk5
type: Protein
entity reference: Cdk5
feature: Cdk5 s19 a25 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Fes-RIGHT__Fes-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 216
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 215
left: Fes
interaction type: STATE_TRANSITION
right: Fes

uniprot R4GJE6 96
type: UnificationXref
id: R4GJE6
db: uniprot

Sema3A
type: Protein
entity reference: Sema3A
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa3 177
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P61585 154
type: UnificationXref
id: P61585
db: uniprot

RhoGEF s23 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RhoGEF
stoichiometric coefficient: 1.0

Sema3A
type: ProteinReference
xref: P00337
standard name: Semaphorin 3A
comment: ENTITY_REFERENCE_NOTES=Long Name: Semaphorin 3A Synonym: Collapsin 1,Sema D,Sema III,Semaphorin D,Semaphorin III Accession: P00337
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.Sema3A
member entity reference: Uncharacterized protein
member entity reference: Semaphorin 3A
member entity reference: Semaphorin-3A
member entity reference: SEMA3A isoform 1

Cyclin-dependent-like kinase 5
type: ProteinReference
xref: uniprot P49615 81
organism: Mus musculus

uniprot P63001 140
type: UnificationXref
id: P63001
db: uniprot

Dihydropyrimidinase-related protein 2
type: ProteinReference
evidence: Evidence 108
xref: uniprot O08553 121
xref: PTHR11647:SF56
organism: Mus musculus

STATE_TRANSITION_LEFT__Complex__CRAM_CRMP_-_ATP-RIGHT__Complex__CRMP_CRAM_-_ADP-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 214
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 212
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 213
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 211
left: Complex (CRAM/CRMP)
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: Complex (CRMP/CRAM)

PARTICIPANT STOICHIOMETRY r20 209
type: Stoichiometry
physical entity: plexinB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 217
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 208
type: Stoichiometry
physical entity: Sema4D
stoichiometric coefficient: 1.0

uniprot O35098 123
type: UnificationXref
id: O35098
db: uniprot

Rac family small GTPase 1b
type: ProteinReference
xref: uniprot Q29RC5 142
xref: PTHR24072:SF105
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re13 218
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Rho

PARTICIPANT STOICHIOMETRY r20 207
type: Stoichiometry
physical entity: RhoGEF
stoichiometric coefficient: 1.0

ncbitaxon 9258 29
type: UnificationXref
id: 9258
db: ncbitaxon

GTP-binding protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot O93467 153
organism: Gallus gallus

uniprot F7CVF2 28
type: UnificationXref
id: F7CVF2
db: uniprot

Ras homolog family member A
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q28GJ8 156
organism: Xenopus tropicalis

uniprot Q14117 126
type: UnificationXref
id: Q14117
db: uniprot

PARTICIPANT STOICHIOMETRY r5 190
type: Stoichiometry
physical entity: Fyn
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 191
type: Stoichiometry
physical entity: Fyn
stoichiometric coefficient: 1.0

uniprot Q9EQF6 33
type: UnificationXref
id: Q9EQF6
db: uniprot

Pak s20 a19 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot D3ZYR4 14
type: UnificationXref
id: D3ZYR4
db: uniprot

Plexin A1
type: ProteinReference
xref: PTHR22625:SF35
xref: uniprot F1P6G0 57
organism: Canis lupus familiaris

uniprot F7FG65 68
type: UnificationXref
id: F7FG65
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot E2RLH2 150
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r4 195
type: Stoichiometry
physical entity: Cdk5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 193
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

plexinB1 s15 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: plexinB1
stoichiometric coefficient: 1.0

uniprot F1P6G0 57
type: UnificationXref
id: F1P6G0
db: uniprot

PARTICIPANT STOICHIOMETRY r4 194
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Dihydropyrimidinase
type: ProteinReference
xref: uniprot Q14117 126
organism: Homo sapiens

Semaphorin-4D
type: ProteinReference
xref: uniprot O09126 18
organism: Mus musculus

uniprot H2R6L6 17
type: UnificationXref
id: H2R6L6
db: uniprot

uniprot K6ZQM1 119
type: UnificationXref
id: K6ZQM1
db: uniprot

uniprot Q6EWH2 76
type: UnificationXref
id: Q6EWH2
db: uniprot

PARTICIPANT STOICHIOMETRY r3 197
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 196
type: Stoichiometry
physical entity: Pak
stoichiometric coefficient: 1.0

uniprot F6UNY1 100
type: UnificationXref
id: F6UNY1
db: uniprot

uniprot O02675 120
type: UnificationXref
id: O02675
db: uniprot

PARTICIPANT STOICHIOMETRY r4 192
type: Stoichiometry
physical entity: Cdk5
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot Q13153 43
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r3 199
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 198
type: Stoichiometry
physical entity: Pak
stoichiometric coefficient: 1.0

ACTIVE 13
type: EntityFeature
comment: Active state

uniprot Q9JHU0 34
type: UnificationXref
id: Q9JHU0
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F6S8L5 66
organism: Xenopus tropicalis

Fyn
type: Protein
entity reference: Fyn
feature: ACTIVE 13
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9031 36
type: UnificationXref
id: 9031
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RIA5 54
xref: PTHR22625:SF35
organism: Macaca mulatta

uniprot Q28GJ8 156
type: UnificationXref
id: Q28GJ8
db: uniprot

uniprot F1LNT0 112
type: UnificationXref
id: F1LNT0
db: uniprot

Neuropilin
type: ProteinReference
xref: PTHR46806:SF4
xref: uniprot E1BMX5 99
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QPB8 86
xref: PTHR11036:SF23
organism: Macaca mulatta

CRMP
type: Protein
entity reference: CRMP
feature: CRMP s11 sa7 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa7 189
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q00535 82
type: UnificationXref
id: Q00535
db: uniprot

By Homology
type: RelationshipTypeVocabulary

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 22

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot D4A584 44
organism: Rattus norvegicus

uniprot P06241 71
type: UnificationXref
id: P06241
db: uniprot

Cytoskeletal dynamics
type: Pathway

uniprot Q13153 43
type: UnificationXref
id: Q13153
db: uniprot

PTHR24072:SF325
type: RelationshipXref
id: PTHR24072:SF325
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QEV2 77
type: UnificationXref
id: A0A1D5QEV2
db: uniprot

Cyclin dependent kinase 5
type: ProteinReference
xref: uniprot A0A2I3SUJ4 78
organism: Pan troglodytes

uniprot Q92888 52
type: UnificationXref
id: Q92888
db: uniprot

ncbitaxon 13616 27
type: UnificationXref
id: 13616
db: ncbitaxon

Cdk5 s28 a18 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Rac
type: ProteinReference
xref: P00340
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras-related C3 botulinum toxin substrate Synonym: Rho family small GTP-binding protein Accession: P00340
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.Rac
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Rac family small GTPase 1b
member entity reference: Rac family small GTPase 1a
member entity reference: Uncharacterized protein
member entity reference: Rac family small GTPase 2
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Rac family small GTPase 3a
member entity reference: Rac family small GTPase 1
member entity reference: GTPase cRac1A
member entity reference: Rac family small GTPase 3b

uniprot Q6LC82 146
type: UnificationXref
id: Q6LC82
db: uniprot

Complex (CRMP/CRAM)
type: Complex
component stoichiometry: CRMP s12 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: CRAM s13 sa9 STOICHIOMETRY ID COMPLEX
component: CRMP
component: CRAM
feature: COMPLEX BINDING FEATURE s40 a38 162
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s40 a38 160
cellular location: cytosol

Complex (Sema4D/plexinB1/ Rac)
type: Complex
component stoichiometry: Sema4D s14 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rac s16 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: plexinB1 s15 sa11 STOICHIOMETRY ID COMPLEX
component: Sema4D
component: Rac
component: plexinB1
feature: COMPLEX BINDING FEATURE s53 a61 174
feature: COMPLEX BINDING FEATURE s53 a61 170
feature: COMPLEX BINDING FEATURE s53 a61 172
cellular location: cytosol

uniprot Q5E9H3 49
type: UnificationXref
id: Q5E9H3
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 27

Rac family small GTPase 2
type: ProteinReference
xref: uniprot Q5U1Y2 143
xref: PTHR24072:SF169
organism: Rattus norvegicus

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

plexinB1
type: Protein
entity reference: plexinB1
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa11 173
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Fyn-RIGHT__Fyn-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 191
left: Fyn
interaction type: STATE_TRANSITION
right: Fyn

uniprot P61586 155
type: UnificationXref
id: P61586
db: uniprot

plexinB1
type: Protein
entity reference: plexinB1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5RIA5 54
type: UnificationXref
id: A0A1D5RIA5
db: uniprot

Semaphorin 3A
type: ProteinReference
xref: uniprot E2QX94 87
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r23 200
type: Stoichiometry
physical entity: Sema4D
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 201
type: Stoichiometry
physical entity: plexinB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 202
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 203
type: Stoichiometry
physical entity: Complex (Sema4D/plexinB1/ Rac)
stoichiometric coefficient: 1.0

uniprot A0JNB0 61
type: UnificationXref
id: A0JNB0
db: uniprot

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 32

PTHR48015:SF20
type: RelationshipXref
id: PTHR48015:SF20
db: PANTHER Family
relationship type: By Homology

CRMP s12 sa8 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Plexin B1
type: ProteinReference
xref: uniprot E1B7F6 3
organism: Bos taurus

uniprot O08553 121
type: UnificationXref
id: O08553
db: uniprot

uniprot A0A2I3RXI4 109
type: UnificationXref
id: A0A2I3RXI4
db: uniprot

ncbitaxon 9615 6
type: UnificationXref
id: 9615
db: ncbitaxon

Semaphorin 4D
type: ProteinReference
xref: uniprot H2R6L6 17
organism: Pan troglodytes

uniprot Q08E52 42
type: UnificationXref
id: Q08E52
db: uniprot

Rho
type: ProteinReference
xref: P00341
standard name: Ras homologue gene family, member A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras homologue gene family, member A Synonym: ARHA Accession: P00341
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.Rho
member entity reference: Rho-related GTP-binding protein RhoA-B
member entity reference: Ras homolog family member A
member entity reference: Novel Rho protein
member entity reference: Transforming protein RhoA
member entity reference: Uncharacterized protein
member entity reference: RHOA isoform 2
member entity reference: GTP-binding protein

plexinB1
type: Protein
entity reference: plexinB1
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa14 167
feature: ACTIVE 13
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Semaphorin-3A
type: ProteinReference
xref: uniprot Q63548 95
organism: Rattus norvegicus

Dihydropyrimidinase like 5
type: ProteinReference
xref: PTHR11647:SF58
xref: uniprot H2R8X1 30
organism: Pan troglodytes

uniprot Q6DGB7 144
type: UnificationXref
id: Q6DGB7
db: uniprot

uniprot Q29RC5 142
type: UnificationXref
id: Q29RC5
db: uniprot

RhoGEF
type: Protein
entity reference: RhoGEF
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24418:SF44
type: RelationshipXref
id: PTHR24418:SF44
db: PANTHER Family
relationship type: By Homology

Rho guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR45872:SF4
xref: uniprot Q61210 51
organism: Mus musculus

uniprot E1BMX5 99
type: UnificationXref
id: E1BMX5
db: uniprot

Neuropilin-1a
type: ProteinReference
xref: uniprot Q8QFX6 105
organism: Danio rerio

CRMP1 isoform 2
type: ProteinReference
xref: PTHR11647:SF54
xref: uniprot A0A2I3RXI4 109
organism: Pan troglodytes

uniprot Q92854 20
type: UnificationXref
id: Q92854
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot F6XSJ9 135
organism: Macaca mulatta

Neuropilin
type: ProteinReference
xref: uniprot A4III3 98
organism: Xenopus tropicalis

RHOA isoform 2
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot H2QML4 152
organism: Pan troglodytes

uniprot A0A1L1RW02 97
type: UnificationXref
id: A0A1L1RW02
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 12

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: uniprot A0JNB0 61
xref: PTHR24418:SF44
organism: Bos taurus

uniprot F6PKK7 65
type: UnificationXref
id: F6PKK7
db: uniprot

uniprot Q05876 74
type: UnificationXref
id: Q05876
db: uniprot

uniprot Q8IPQ2 132
type: UnificationXref
id: Q8IPQ2
db: uniprot

Sema4D
type: ProteinReference
xref: P00329
standard name: Semaphorin 4D
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.Sema4D
comment: ENTITY_REFERENCE_NOTES=Long Name: Semaphorin 4D Synonym: CD100,Coll4,Collapsin 4,Leukocyte activation antigen CD100,Sema J,Semaphorin J Accession: P00329
member entity reference: Semaphorin 4D
member entity reference: Semaphorin-4D
member entity reference: Uncharacterized protein

Neuropilin
type: ProteinReference
xref: PTHR46806:SF4
xref: uniprot F6UNY1 100
organism: Canis lupus familiaris

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot P39688 72
organism: Mus musculus

CRAM s10 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRAM
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FXK5 117
organism: Macaca mulatta

Pak
type: Protein
entity reference: Pak
feature: Pak s20 a19 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Semaphorin-4D
type: ProteinReference
xref: uniprot Q92854 20
organism: Homo sapiens

Fyn
type: Protein
entity reference: Fyn
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24072:SF153
type: RelationshipXref
id: PTHR24072:SF153
db: PANTHER Family
relationship type: By Homology

uniprot H2QUV1 92
type: UnificationXref
id: H2QUV1
db: uniprot

uniprot D3Z981 55
type: UnificationXref
id: D3Z981
db: uniprot

Semaphorin-3A
type: ProteinReference
xref: uniprot O08665 93
organism: Mus musculus

uniprot A0A1D5QPB8 86
type: UnificationXref
id: A0A1D5QPB8
db: uniprot

plexinB1 s22 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: plexinB1
stoichiometric coefficient: 1.0

Danio rerio
type: BioSource
xref: ncbitaxon 7955 64

Sema3A
type: Protein
entity reference: Sema3A
comment: SPECIES_TYPE=PROTEIN

uniprot Q8QFX6 105
type: UnificationXref
id: Q8QFX6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Cdk5-_ATP-RIGHT__ADP-_Cdk5-_r4
controller: Fyn

Cyclin-dependent kinase 5 homolog
type: ProteinReference
xref: uniprot P48609 79
organism: Drosophila melanogaster

uniprot F7AVR4 91
type: UnificationXref
id: F7AVR4
db: uniprot

uniprot Q28HZ4 157
type: UnificationXref
id: Q28HZ4
db: uniprot

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot F7CS91 151
organism: Monodelphis domestica

HETERODIMER_ASSOCIATION_LEFT__Sema3A-_Complex__PlexinA1_Neuropilin_1_-RIGHT__Complex__Sema3A_Neuropilin_1__PlexinA1_-_r2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 206
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 205
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 204
left: Sema3A
left: Complex (PlexinA1/Neuropilin 1)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Sema3A/Neuropilin 1/ PlexinA1)

PLXNB1 isoform 1
type: ProteinReference
xref: uniprot H2QMJ0 9
organism: Pan troglodytes

uniprot F6ZT50 26
type: UnificationXref
id: F6ZT50
db: uniprot

STATE_TRANSITION_LEFT__Pak-_ATP-RIGHT__Pak-_ADP-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 197
left: Pak
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: Pak

Tyrosine-protein kinase Fes/Fps
type: ProteinReference
xref: uniprot P16879 48
organism: Mus musculus

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot A0A2I3SKP4 60
organism: Pan troglodytes

uniprot E1C3P6 35
type: UnificationXref
id: E1C3P6
db: uniprot

uniprot F6S8L5 66
type: UnificationXref
id: F6S8L5
db: uniprot

P00338
type: UnificationXref
id: P00338
db: PANTHER Pathway Component

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

P00339
type: UnificationXref
id: P00339
db: PANTHER Pathway Component

P00334
type: UnificationXref
id: P00334
db: PANTHER Pathway Component

Cdk5
type: Protein
entity reference: Cdk5
feature: ACTIVE 13
feature: Cdk5 s28 a18 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P00335
type: UnificationXref
id: P00335
db: PANTHER Pathway Component

P00336
type: UnificationXref
id: P00336
db: PANTHER Pathway Component

Tyrosine-protein kinase fyna
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot Q6EWH2 76
organism: Danio rerio

uniprot O09126 18
type: UnificationXref
id: O09126
db: uniprot

ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

P00337
type: UnificationXref
id: P00337
db: PANTHER Pathway Component

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 13
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P00341
type: UnificationXref
id: P00341
db: PANTHER Pathway Component

PlexinA1 s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PlexinA1
stoichiometric coefficient: 1.0

P00340
type: UnificationXref
id: P00340
db: PANTHER Pathway Component

ncbitaxon 7227 80
type: UnificationXref
id: 7227
db: ncbitaxon

CRAM
type: Protein
entity reference: CRAM
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa6 187
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Fyn-RIGHT__Fyn-_r5
controller: Complex (Sema3A/Neuropilin 1/ PlexinA1)

uniprot P39688 72
type: UnificationXref
id: P39688
db: uniprot

Rho guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR45872:SF4
xref: uniprot Q92888 52
organism: Homo sapiens

Dihydropyrimidinase-related protein 5
type: ProteinReference
xref: uniprot Q9EQF6 33
xref: PTHR11647:SF58
organism: Mus musculus

Dihydropyrimidinase
type: ProteinReference
xref: uniprot Q9EQF5 133
organism: Mus musculus

uniprot H2QA35 46
type: UnificationXref
id: H2QA35
db: uniprot

P00329
type: UnificationXref
id: P00329
db: PANTHER Pathway Component

Plexin-B1
type: ProteinReference
xref: uniprot O43157 11
organism: Homo sapiens

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

P00328
type: UnificationXref
id: P00328
db: PANTHER Pathway Component

CRMP s12 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRMP
stoichiometric coefficient: 1.0

Collapsin response mediator protein
type: ProteinReference
xref: uniprot Q8IPQ2 132
organism: Drosophila melanogaster

P00333
type: UnificationXref
id: P00333
db: PANTHER Pathway Component

uniprot F6U213 7
type: UnificationXref
id: F6U213
db: uniprot

P00332
type: UnificationXref
id: P00332
db: PANTHER Pathway Component

ncbitaxon 9606 12
type: UnificationXref
id: 9606
db: ncbitaxon

Neuropilin 1 s8 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Neuropilin 1
stoichiometric coefficient: 1.0

P00331
type: UnificationXref
id: P00331
db: PANTHER Pathway Component

P00330
type: UnificationXref
id: P00330
db: PANTHER Pathway Component

Cdk5 s19 a25 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot Q9QUI0 159
organism: Mus musculus

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q05144 141
xref: PTHR24072:SF169
organism: Mus musculus

Dihydropyrimidinase-related protein 1
type: ProteinReference
xref: PTHR11647:SF54
xref: uniprot Q14194 127
organism: Homo sapiens

Rac family small GTPase 1
type: ProteinReference
xref: uniprot Q6GL60 145
xref: PTHR24072:SF105
organism: Xenopus tropicalis

uniprot A9JRY8 134
type: UnificationXref
id: A9JRY8
db: uniprot

uniprot H2QGF2 50
type: UnificationXref
id: H2QGF2
db: uniprot

Pak s27 a24 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PANTHER Pathway P00007 1
type: UnificationXref
id: P00007
db: PANTHER Pathway

uniprot F1RDG9 63
type: UnificationXref
id: F1RDG9
db: uniprot

CRMP
type: ProteinReference
xref: P00339
standard name: Collapsin response mediator protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.CRMP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dihydropyrimidinase-related protein 2
member entity reference: Uncharacterized protein
member entity reference: Dihydropyrimidinase
member entity reference: DPYSL4 isoform 1
member entity reference: Dihydropyrimidinase-related protein 4
member entity reference: Dihydropyrimidinase-related protein 1
member entity reference: Dihydropyrimidinase-related protein 3
member entity reference: Collapsin response mediator protein
member entity reference: Dihydropyrimidinase like 4
member entity reference: CRMP1 isoform 2
member entity reference: DPYSL4 protein
member entity reference: DPYSL2 isoform 2

Cyclin-dependent-like kinase 5
type: ProteinReference
xref: uniprot Q00535 82
organism: Homo sapiens

CRMP s11 sa7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Pak
type: Protein
entity reference: Pak
feature: Pak s27 a24 rs1
feature: ACTIVE 13
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dihydropyrimidinase-related protein 3
type: ProteinReference
xref: PTHR11647:SF57
xref: uniprot Q6GL72 131
organism: Xenopus tropicalis

uniprot Q6GL72 131
type: UnificationXref
id: Q6GL72
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 15

uniprot Q6DHM9 158
type: UnificationXref
id: Q6DHM9
db: uniprot

Rho guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR45872:SF4
xref: uniprot Q9Z1I6 53
organism: Rattus norvegicus

uniprot Q02399 83
type: UnificationXref
id: Q02399
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot E1BFR4 56
type: UnificationXref
id: E1BFR4
db: uniprot

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot P06241 71
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FCM4 16
organism: Macaca mulatta

uniprot Q9TU25 149
type: UnificationXref
id: Q9TU25
db: uniprot

uniprot F1PUK7 45
type: UnificationXref
id: F1PUK7
db: uniprot

ncbitaxon 9544 8
type: UnificationXref
id: 9544
db: ncbitaxon

CRMP
type: Protein
entity reference: CRMP
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa8 161
feature: CRMP s12 sa8 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P63000 139
type: UnificationXref
id: P63000
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pak-_ATP-RIGHT__Pak-_ADP-_r3
controller: Rac

Rho
type: Protein
entity reference: Rho
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dihydropyrimidinase like 5
type: ProteinReference
xref: uniprot F1PK01 24
xref: PTHR11647:SF58
organism: Canis lupus familiaris

PTHR22625:SF35
type: RelationshipXref
id: PTHR22625:SF35
db: PANTHER Family
relationship type: By Homology

eco ECO:0000250 22
type: UnificationXref
id: ECO:0000250
db: eco

DPYSL4 protein
type: ProteinReference
xref: uniprot A2VDS7 110
organism: Bos taurus

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot F6PKK7 65
organism: Macaca mulatta

Plexin B1
type: ProteinReference
xref: uniprot E2RM56 5
organism: Canis lupus familiaris

Neuropilin 1 s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Neuropilin 1
stoichiometric coefficient: 1.0

uniprot A0A2I3SUJ4 78
type: UnificationXref
id: A0A2I3SUJ4
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q63548 95
type: UnificationXref
id: Q63548
db: uniprot

Dihydropyrimidinase-related protein 5
type: ProteinReference
xref: uniprot Q9JHU0 34
xref: PTHR11647:SF58
organism: Rattus norvegicus

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

uniprot F7FCM4 16
type: UnificationXref
id: F7FCM4
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Complex (CRMP/CRAM)

PTHR11647:SF54
type: RelationshipXref
id: PTHR11647:SF54
db: PANTHER Family
relationship type: By Homology

PTHR11647:SF58
type: RelationshipXref
id: PTHR11647:SF58
db: PANTHER Family
relationship type: By Homology

Neuropilin 1
type: ProteinReference
xref: P00338
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.RECEPTOR.Neuropilin 1
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Neuropilin-1
member entity reference: Neuropilin
member entity reference: Neuropilin-1a

PTHR11647:SF57
type: RelationshipXref
id: PTHR11647:SF57
db: PANTHER Family
relationship type: By Homology

PTHR11647:SF56
type: RelationshipXref
id: PTHR11647:SF56
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Rho-RIGHT__Rho-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 218
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 217
left: Rho
interaction type: STATE_TRANSITION
right: Rho

uniprot A4III3 98
type: UnificationXref
id: A4III3
db: uniprot

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F1PUK7 45
organism: Canis lupus familiaris

Tyrosine-protein kinase Fyn
type: ProteinReference
xref: PTHR24418:SF44
xref: uniprot Q05876 74
organism: Gallus gallus

Semaphorin 4D
type: ProteinReference
xref: uniprot D3ZYR4 14
organism: Rattus norvegicus

uniprot H2QMJ0 9
type: UnificationXref
id: H2QMJ0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__CRAM_CRMP_-_ATP-RIGHT__Complex__CRMP_CRAM_-_ADP-_r9
controller: Fes

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Cytoskeletal dynamics
controller: Pak

Tyrosine-protein kinase Fes/Fps
type: ProteinReference
xref: uniprot P07332 47
organism: Homo sapiens

uniprot E2RLH2 150
type: UnificationXref
id: E2RLH2
db: uniprot

Neuropilin 1
type: Protein
entity reference: Neuropilin 1
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 185
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Semaphorin-3A
type: ProteinReference
xref: uniprot R4GJE6 96
xref: PTHR11036:SF23
organism: Gallus gallus

uniprot F7FXK5 117
type: UnificationXref
id: F7FXK5
db: uniprot

Complex (Sema3A/Neuropilin 1/ PlexinA1)
type: Complex
component stoichiometry: Sema3A s7 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Neuropilin 1 s8 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: PlexinA1 s9 sa5 STOICHIOMETRY ID COMPLEX
component: PlexinA1
component: Sema3A
component: Neuropilin 1
feature: COMPLEX BINDING FEATURE s17 a16 176
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s17 a16 178
feature: COMPLEX BINDING FEATURE s17 a16 180
cellular location: cytosol

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot P35465 41
xref: PTHR48015:SF20
organism: Rattus norvegicus

uniprot Q9Z1I6 53
type: UnificationXref
id: Q9Z1I6
db: uniprot

uniprot P49615 81
type: UnificationXref
id: P49615
db: uniprot

Fes
type: ProteinReference
xref: P00332
standard name: Oncogene FES
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.GENERIC.Fes
comment: ENTITY_REFERENCE_NOTES=Long Name: Oncogene FES Synonym: Feline sarcoma oncogene Accession: P00332
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase Fes/Fps

uniprot O43157 11
type: UnificationXref
id: O43157
db: uniprot

IDA
type: EvidenceCodeVocabulary

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XUP1 38
xref: PTHR48015:SF20
organism: Macaca mulatta

Rac family small GTPase 3b
type: ProteinReference
xref: uniprot A9JRY8 134
xref: PTHR24072:SF301
organism: Danio rerio

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Semaphorin-3A
type: ProteinReference
xref: uniprot Q14563 94
organism: Homo sapiens

Dihydropyrimidinase-related protein 4
type: ProteinReference
xref: uniprot O35098 123
organism: Mus musculus

plexinB1
type: ProteinReference
xref: P00328
standard name: Plexin B1
comment: ENTITY_REFERENCE_NOTES=Long Name: Plexin B1 Synonym: PLXN5,PLXNB1,Plexin 5,SEP,Transmembrane protein SEP Accession: P00328
comment: ENTITY_REFERENCE_ID_DESC=Axon guidance mediated by semaphorins.PROTEIN.RECEPTOR.plexinB1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: PLXNB1 isoform 1
member entity reference: Plexin-B1
member entity reference: Uncharacterized protein
member entity reference: Plexin B1

Dihydropyrimidinase-related protein 2
type: ProteinReference
xref: uniprot Q16555 128
xref: PTHR11647:SF56
organism: Homo sapiens

Sema4D s14 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Sema4D
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Fes-RIGHT__Fes-_r8
controller: Complex (Sema3A/Neuropilin 1/ PlexinA1)

PARTICIPANT STOICHIOMETRY r8 215
type: Stoichiometry
physical entity: Fes
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 216
type: Stoichiometry
physical entity: Fes
stoichiometric coefficient: 1.0

Complex (CRAM/CRMP)
type: Complex
component stoichiometry: CRAM s10 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: CRMP s11 sa7 STOICHIOMETRY ID COMPLEX
component: CRMP
component: CRAM
feature: COMPLEX BINDING FEATURE s37 a34 186
feature: COMPLEX BINDING FEATURE s37 a34 188
cellular location: cytosol