TRANSPORT_LEFT__TGFbetaR_I-RIGHT__TGFbetaR_I-_re14
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 214
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 213
left: TGFbetaR I
interaction type: TRANSPORT
right: TGFbetaR I

TSG
type: ProteinReference
xref: P06242
standard name: twisted gastrulation
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.TSG
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein twisted gastrulation

TGFbetaR I s171 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

Co Smad s248 sa79 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Co-Smad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re44 215
type: Stoichiometry
physical entity: pro ligand dimer
stoichiometric coefficient: 1.0

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

PARTICIPANT STOICHIOMETRY re44 216
type: Stoichiometry
physical entity: proDPP
stoichiometric coefficient: 1.0

HOMODIMER ID 53STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re33 179
type: Stoichiometry
physical entity: Co-Smad
stoichiometric coefficient: 1.0

BMP ligand TGFbetaR II
type: Complex
component stoichiometry: HOMODIMER ID 62STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 19STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
component: TGFbetaR II
feature: COMPLEX BINDING FEATURE s228 csa22 170
feature: COMPLEX BINDING FEATURE s228 csa22 172
cellular location: cytosol

TRANSPORT_LEFT__TGFbetaR_II-RIGHT__TGFbetaR_II-_re16
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 203
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 204
left: TGFbetaR II
interaction type: TRANSPORT
right: TGFbetaR II

STATE_TRANSITION_LEFT__TGFbetaR_II-RIGHT__TGFbetaR_II-_re15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 209
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 208
left: TGFbetaR II
interaction type: STATE_TRANSITION
right: TGFbetaR II

TGFbetaR II
type: Protein
entity reference: TGFbetaR II
feature: TGFbetaR II s183 sa55 rs1

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s261 sa103 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s261 sa103 113
feature: R Smad s261 sa103 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Co Smad s246 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Co-Smad
stoichiometric coefficient: 1.0

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s250 sa70 rs2
feature: R Smad s250 sa70 rs1

PARTICIPANT STOICHIOMETRY re6 186
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

TRUNCATION_LEFT__pro_ligand_dimer-RIGHT__?-_BMP_orthologous_ligand-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 184
left: pro ligand dimer
interaction type: TRUNCATION
right: BMP orthologous ligand
right: ?

PARTICIPANT STOICHIOMETRY re6 184
type: Stoichiometry
physical entity: pro ligand dimer
stoichiometric coefficient: 1.0

uniprot Q5U110 73
type: UnificationXref
id: Q5U110
db: uniprot

Protein twisted gastrulation
type: ProteinReference
xref: PTHR12312:SF16
xref: uniprot P54356 75
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re6 185
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

GO GO:0005783 5
type: UnificationXref
id: GO:0005783
db: GO

P06245
type: UnificationXref
id: P06245
db: PANTHER Pathway Component

P06244
type: UnificationXref
id: P06244
db: PANTHER Pathway Component

P06247
type: UnificationXref
id: P06247
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re3 199
type: Stoichiometry
physical entity: ligand TGFbetaR I TGFbetaR II
stoichiometric coefficient: 1.0

P06246
type: UnificationXref
id: P06246
db: PANTHER Pathway Component

P06249
type: UnificationXref
id: P06249
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re33 180
type: Stoichiometry
physical entity: Co-Smad
stoichiometric coefficient: 1.0

P06248
type: UnificationXref
id: P06248
db: PANTHER Pathway Component

pro ligand dimer
type: Complex
component stoichiometry: HOMODIMER ID 82STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 55STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
component: ?
feature: COMPLEX BINDING FEATURE s167 csa4 144
feature: COMPLEX BINDING FEATURE s167 csa4 146
cellular location: Golgi apparatus

TGFbetaR II s195 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

P06241
type: UnificationXref
id: P06241
db: PANTHER Pathway Component

P06243
type: UnificationXref
id: P06243
db: PANTHER Pathway Component

P06242
type: UnificationXref
id: P06242
db: PANTHER Pathway Component

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 7

uniprot Q24025 83
type: UnificationXref
id: Q24025
db: uniprot

Smurf
type: Protein
entity reference: Smurf
feature: COMPLEX PARTICIPANT BINDING FEATURE s259 sa102 127
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BMP orthologous ligand
type: Protein

PTHR13703:SF61
type: RelationshipXref
id: PTHR13703:SF61
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__BMP_orthologous_ligand-_TGFbetaR_II-RIGHT__BMP_ligand_TGFbetaR_II-_re54
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re54 256
participant stoichiometry: PARTICIPANT STOICHIOMETRY re54 255
participant stoichiometry: PARTICIPANT STOICHIOMETRY re54 254
left: TGFbetaR II
left: BMP orthologous ligand
interaction type: HETERODIMER_ASSOCIATION
right: BMP ligand TGFbetaR II

HOMODIMER ID 60STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

uniprot A0A0B4K7J3 38
type: UnificationXref
id: A0A0B4K7J3
db: uniprot

PPM1A
type: ProteinReference
xref: P06247
standard name: protein phosphatase 2C alpha, beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.PPM1A
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Alphabet, isoform E

PARTICIPANT STOICHIOMETRY re55 251
type: Stoichiometry
physical entity: ligand TGFbetaR I TGFbetaR II
stoichiometric coefficient: 1.0

?
type: Complex
component stoichiometry: ? s166 sa18 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s166 sa18 147
cellular location: Golgi apparatus

PARTICIPANT STOICHIOMETRY re55 250
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

HOMODIMER ID 62STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

DISSOCIATION_LEFT__SOG_TSG_DPP_dimer-RIGHT__BMP_orthologous_ligand-_TSG-_SOG-_re12
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 221
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 224
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 223
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 222
left: SOG/TSG DPP dimer
interaction type: DISSOCIATION
right: SOG
right: BMP orthologous ligand
right: TSG

TGFbetaR II s177 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

?
type: Complex
component stoichiometry: ? s23 sa19 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa19 141
cellular location: unknown c3

HOMODIMER ID 80STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

?
type: Complex
component stoichiometry: ? s35 sa109 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa109 165

Full length BMP orthologous ligand s159 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Full-length BMP orthologous ligand
stoichiometric coefficient: 2.0

HOMODIMER ID 56STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__ligand_phosphoTGFbetaR_I_TGFbetaR_II-_I_Smad-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_I_Smad-_re38
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 176
left: I-Smad
left: ligand/phosphoTGFbetaR I TGFbetaR II
interaction type: HETERODIMER_ASSOCIATION
right: ligand/phosphoTGFbetaR I TGFbetaR II I-Smad

PPM1A
type: Protein
entity reference: PPM1A
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

BMP orthologous ligand
type: Protein

PTHR47992:SF25
type: RelationshipXref
id: PTHR47992:SF25
db: PANTHER Family
relationship type: By Homology

uniprot O62609 25
type: UnificationXref
id: O62609
db: uniprot

Mothers against decapentaplegic homolog
type: ProteinReference
xref: uniprot O96660 63
organism: Drosophila melanogaster

TGFbetaR I
type: Protein
entity reference: TGFbetaR I
feature: TGFbetaR I s224 sa8 rs1

Smurf s262 sa104 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smurf
stoichiometric coefficient: 1.0

TGFbetaR I
type: Protein
entity reference: TGFbetaR I
feature: TGFbetaR I s168 sa2 rs1

TGFbetaR I s168 sa2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

Smurf
type: Protein
entity reference: Smurf
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__ligand_TGFbetaR_I_TGFbetaR_II-_ATP-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II-_ADP-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 200
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 202
left: ATP
left: ligand TGFbetaR I TGFbetaR II
interaction type: STATE_TRANSITION
right: ADP
right: ligand/phosphoTGFbetaR I TGFbetaR II

TGFbetaR I s190 sa56 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

Co Smad s247 sa76 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Co-Smad
stoichiometric coefficient: 1.0

TGFbetaR II s227 sa126 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

SOG s50 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

SHN s109 sa77 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SHN
stoichiometric coefficient: 1.0

HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

TGFbetaR II s181 sa43 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.42

HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

TGFbetaR I s172 sa39 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s232 sa64 rs1
feature: R Smad s232 sa64 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TGFbetaR II s182 sa45 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.42

PARTICIPANT STOICHIOMETRY re4 195
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re4 194
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re4 193
type: Stoichiometry
physical entity: Full-length BMP orthologous ligand
stoichiometric coefficient: 2.0

PTHR13703:SF54
type: RelationshipXref
id: PTHR13703:SF54
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re55 249
type: Stoichiometry
physical entity: BMP ligand TGFbetaR II
stoichiometric coefficient: 1.0

R Smad s233 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 3.0

TGFbetaR II s180 sa42 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.42

uniprot O96660 63
type: UnificationXref
id: O96660
db: uniprot

PARTICIPANT STOICHIOMETRY re54 254
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re54 256
type: Stoichiometry
physical entity: BMP ligand TGFbetaR II
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re54 255
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

PTHR11848:SF54
type: RelationshipXref
id: PTHR11848:SF54
db: PANTHER Family
relationship type: By Homology

TSG
type: Protein
entity reference: TSG
comment: SPECIES_TYPE=PROTEIN

I-Smad
type: Protein
entity reference: I-Smad
feature: COMPLEX PARTICIPANT BINDING FEATURE s255 sa99 111
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

?
type: Protein

?
type: Protein

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 2

R Smad s234 sa66 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

R-Smad
type: ProteinReference
xref: P06245
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.R_minus_Smad
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mothers against decapentaplegic homolog
member entity reference: Protein mothers against dpp

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

NEJ/MED/ phosphoMAD
type: Complex
component stoichiometry: Co Smad s248 sa79 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 69STOICHIOMETRY ID COMPLEX
component stoichiometry: NEJ s115 sa81 STOICHIOMETRY ID COMPLEX
component: Co-Smad
component: R-Smad
component: NEJ
feature: COMPLEX BINDING FEATURE s116 csa15 134
feature: COMPLEX BINDING FEATURE s116 csa15 136
feature: COMPLEX BINDING FEATURE s116 csa15 138
cellular location: nucleus

TGFbetaR II s177 sa1 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.42

P06254
type: UnificationXref
id: P06254
db: PANTHER Pathway Component

eco ECO:0000245 8
type: UnificationXref
id: ECO:0000245
db: eco

TSG
type: Protein
entity reference: TSG
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa38 153
comment: SPECIES_TYPE=PROTEIN

P06252
type: UnificationXref
id: P06252
db: PANTHER Pathway Component

HOMODIMER ID 81STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

P06250
type: UnificationXref
id: P06250
db: PANTHER Pathway Component

R Smad s237 sa78 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

ligand/phosphoTGFbetaR I TGFbetaR II R-Smad
type: Complex
component stoichiometry: R Smad s230 sa48 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 45STOICHIOMETRY ID COMPLEX
component: R-Smad
component: BMP orthologous ligand
component: TGFbetaR I
component: TGFbetaR II
feature: COMPLEX BINDING FEATURE s242 csa9 122
feature: COMPLEX BINDING FEATURE s242 csa9 118
feature: COMPLEX BINDING FEATURE s242 csa9 120
feature: COMPLEX BINDING FEATURE s242 csa9 116
cellular location: cytosol

TGFbetaR II
type: ProteinReference
xref: P06255
standard name: TGF-beta receptor type II
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.RECEPTOR.TGF_beta_R II
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase
member entity reference: Serine/threonine-protein kinase receptor

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P06255
type: UnificationXref
id: P06255
db: PANTHER Pathway Component

P06256
type: UnificationXref
id: P06256
db: PANTHER Pathway Component

uniprot P07713 30
type: UnificationXref
id: P07713
db: uniprot

Furin
type: Protein
entity reference: Furin
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF63
xref: uniprot M9PE88 11
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re26 245
type: Stoichiometry
physical entity: SHN/MED/ phosphoMAD
stoichiometric coefficient: 1.0

BMP orthologous ligand
type: Protein

TGFbetaR I s176 sa96 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

R Smad s237 sa78 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Dorsal-ventral patterning protein Sog
type: ProteinReference
xref: PTHR46526:SF1
xref: uniprot Q24025 83
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Co_Smad_phospho_R_Smad-RIGHT__Co_Smad-_R_Smad-_re32
controller: PPM1A

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 5

PTHR13832:SF571
type: RelationshipXref
id: PTHR13832:SF571
db: PANTHER Family
relationship type: By Homology

R Smad s234 sa66 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

TRUNCATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re26 244
type: Stoichiometry
physical entity: Co-Smad phospho R-Smad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 243
type: Stoichiometry
physical entity: SHN
stoichiometric coefficient: 1.0

Furin
type: ProteinReference
xref: P06244
standard name: furin 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.Furin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Furin-like protease 1, isoforms 1/1-X/2

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s235 sa75 rs2
feature: R Smad s235 sa75 rs1

PARTICIPANT STOICHIOMETRY re13 217
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 218
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

R Smad s230 sa48 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

I-Smad
type: Protein
entity reference: I-Smad
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoR_Smad_Smurf-RIGHT__phospho_ubiq_R_Smad_Smurf-_re41
controller: Smurf

HETERODIMER_ASSOCIATION_LEFT__R_Smad-_ligand_phosphoTGFbetaR_I_TGFbetaR_II-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_R_Smad-_re17
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 196
left: R-Smad
left: ligand/phosphoTGFbetaR I TGFbetaR II
interaction type: HETERODIMER_ASSOCIATION
right: ligand/phosphoTGFbetaR I TGFbetaR II R-Smad

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s233 sa65 rs2
feature: R Smad s233 sa65 rs1

? s27 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

TGFbetaR I s174 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

HOMODIMER ID 19STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

R Smad s264 sa101 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

SOG
type: ProteinReference
xref: P06252
standard name: short gastrulation
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.SOG
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dorsal-ventral patterning protein Sog

TRUNCATION_LEFT__Full_length__BMP_orthologous_ligand-RIGHT__BMP_orthologous_ligand-_?-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 193
left: Full-length BMP orthologous ligand
interaction type: TRUNCATION
right: BMP orthologous ligand
right: ?

R Smad s235 sa75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 2.0

BMP orthologous ligand s152 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

TGFbetaR I s168 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

uniprot Q9V4F4 35
type: UnificationXref
id: Q9V4F4
db: uniprot

NEJ s115 sa81 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NEJ
stoichiometric coefficient: 1.0

PANTHER Pathway P06211 1
type: UnificationXref
id: P06211
db: PANTHER Pathway

R Smad s233 sa65 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

R Smad s230 sa48 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ACTIVE 66
type: EntityFeature
comment: Active state

R Smad s264 sa101 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR46526:SF1
type: RelationshipXref
id: PTHR46526:SF1
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re11 228
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__BMP_ligand_TGFbetaR_I-_TGFbetaR_II-RIGHT__ligand_TGFbetaR_I_TGFbetaR_II-_re46
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 207
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 206
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 205
left: BMP ligand TGFbetaR I
left: TGFbetaR II
interaction type: HETERODIMER_ASSOCIATION
right: ligand TGFbetaR I TGFbetaR II

00696
type: UnificationXref
id: MOD:00696
db: mod

R Smad s241 sa105 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re11 229
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_R_Smad-_ATP-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_phosphoR_Smad-_ADP-_re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 188
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 187
left: ATP
left: ligand/phosphoTGFbetaR I TGFbetaR II R-Smad
interaction type: STATE_TRANSITION
right: ligand/phosphoTGFbetaR I TGFbetaR II phosphoR-Smad
right: ADP

BMP orthologous ligand s192 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 72

TGFbetaR I
type: Protein
entity reference: TGFbetaR I
feature: TGFbetaR I s200 sa5 rs1

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s238 sa89 rs2
feature: R Smad s238 sa89 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re56 247
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

SOG/TSG DPP dimer
type: Complex
component stoichiometry: HOMODIMER ID 54STOICHIOMETRY ID COMPLEX
component stoichiometry: TSG s51 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOG s50 sa37 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
component: TSG
component: SOG
feature: COMPLEX BINDING FEATURE s48 csa8 148
feature: COMPLEX BINDING FEATURE s48 csa8 150
feature: COMPLEX BINDING FEATURE s48 csa8 152

PARTICIPANT STOICHIOMETRY re56 246
type: Stoichiometry
physical entity: proDPP
stoichiometric coefficient: 1.0

? s166 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

BMP orthologous ligand s153 sa108 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

TGFbetaR II
type: Protein
entity reference: TGFbetaR II
feature: TGFbetaR II s182 sa45 rs1

R Smad s250 sa70 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re32 181
type: Stoichiometry
physical entity: Co-Smad phospho R-Smad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 182
type: Stoichiometry
physical entity: Co-Smad
stoichiometric coefficient: 1.0

TGFbetaR I
type: Protein
entity reference: TGFbetaR I
feature: TGFbetaR I s173 sa41 rs1

PARTICIPANT STOICHIOMETRY re32 183
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 252
type: Stoichiometry
physical entity: Co-Smad phospho R-Smad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 253
type: Stoichiometry
physical entity: Co-Smad phospho R-Smad
stoichiometric coefficient: 1.0

uniprot Q9VQG9 36
type: UnificationXref
id: Q9VQG9
db: uniprot

PTHR23255:SF98
type: RelationshipXref
id: PTHR23255:SF98
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re56 248
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

Furin
type: Protein
entity reference: Furin
cellular location: unknown c3
comment: SPECIES_TYPE=PROTEIN

I-Smad
type: ProteinReference
xref: P06250
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.I_minus_Smad
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mothers against decapentaplegic homolog

uniprot P54631 33
type: UnificationXref
id: P54631
db: uniprot

TRANSPORT_LEFT__BMP_orthologous_ligand-RIGHT__BMP_orthologous_ligand-_re11
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 228
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 229
left: BMP orthologous ligand
interaction type: TRANSPORT
right: BMP orthologous ligand

BMP orthologous ligand s154 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

R Smad s250 sa70 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

? s23 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PTHR45645:SF8
type: RelationshipXref
id: PTHR45645:SF8
db: PANTHER Family
relationship type: By Homology

Protein mothers against dpp
type: ProteinReference
xref: uniprot P42003 64
xref: PTHR13703:SF61
organism: Drosophila melanogaster

R-Smad
type: Protein
entity reference: R-Smad
feature: COMPLEX PARTICIPANT BINDING FEATURE s230 sa48 121
feature: R Smad s230 sa48 rs2
feature: ACTIVE 66
feature: R Smad s230 sa48 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re22 257
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

ligand/phosphoTGFbetaR I TGFbetaR II phosphoR-Smad
type: Complex
component stoichiometry: R Smad s231 sa58 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 17STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
component: R-Smad
component: TGFbetaR II
component: TGFbetaR I
component: BMP orthologous ligand
feature: COMPLEX BINDING FEATURE s243 csa10 154
feature: COMPLEX BINDING FEATURE s243 csa10 160
feature: COMPLEX BINDING FEATURE s243 csa10 156
feature: COMPLEX BINDING FEATURE s243 csa10 158
cellular location: cytosol

PTHR11848:SF263
type: RelationshipXref
id: PTHR11848:SF263
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re22 258
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 3.0

PTHR11848:SF262
type: RelationshipXref
id: PTHR11848:SF262
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__pro_ligand_dimer-RIGHT__proDPP-_re44
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 216
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 215
left: pro ligand dimer
interaction type: TRANSPORT
right: proDPP

TSG s51 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

TGFbetaR I
type: Protein
entity reference: TGFbetaR I
feature: TGFbetaR I s174 sa46 rs1

PARTICIPANT STOICHIOMETRY re3 201
type: Stoichiometry
physical entity: ligand/phosphoTGFbetaR I TGFbetaR II
stoichiometric coefficient: 1.0

TGFbetaR II s227 sa126 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.42

PARTICIPANT STOICHIOMETRY re3 200
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 8.0

Protein decapentaplegic
type: ProteinReference
evidence: Evidence 31
xref: PTHR11848:SF54
xref: uniprot P07713 30
organism: Drosophila melanogaster

TGFbetaR II s188 sa95 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

Co-Smad
type: Protein
entity reference: Co-Smad
feature: COMPLEX PARTICIPANT BINDING FEATURE s246 sa71 97
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Receptor protein serine/threonine kinase
type: ProteinReference
evidence: Evidence 41
evidence: Evidence 40
xref: uniprot A1Z7L8 39
xref: PTHR23255:SF71
organism: Drosophila melanogaster

TGFbetaR I
type: Protein
entity reference: TGFbetaR I
feature: TGFbetaR I s172 sa39 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000316 28
type: UnificationXref
id: ECO:0000316
db: eco

HETERODIMER_ASSOCIATION_LEFT__SHN-_Co_Smad_phospho_R_Smad-RIGHT__SHN_MED__phosphoMAD-_re26
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 244
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 243
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 245
left: Co-Smad phospho R-Smad
left: SHN
interaction type: HETERODIMER_ASSOCIATION
right: SHN/MED/ phosphoMAD

PARTICIPANT STOICHIOMETRY re40 237
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re3 202
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 8.0

PARTICIPANT STOICHIOMETRY re40 236
type: Stoichiometry
physical entity: Co-Smad
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

Co-Smad phospho R-Smad
type: Complex
component stoichiometry: HOMODIMER ID 70STOICHIOMETRY ID COMPLEX
component stoichiometry: Co Smad s246 sa71 STOICHIOMETRY ID COMPLEX
component: Co-Smad
component: R-Smad
feature: COMPLEX BINDING FEATURE s253 csa13 94
feature: COMPLEX BINDING FEATURE s253 csa13 96
cellular location: nucleus

PARTICIPANT STOICHIOMETRY re40 239
type: Stoichiometry
physical entity: Co-Smad phospho R-Smad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re40 238
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

HOMODIMER ID 82STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

BMP orthologous ligand
type: Protein

TGFbetaR I s173 sa41 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

TGFbetaR II s188 sa95 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.42

uniprot A1Z7L8 39
type: UnificationXref
id: A1Z7L8
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__BMP_ligand_TGFbetaR_II-_TGFbetaR_I-RIGHT__ligand_TGFbetaR_I_TGFbetaR_II-_re55
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re55 251
participant stoichiometry: PARTICIPANT STOICHIOMETRY re55 250
participant stoichiometry: PARTICIPANT STOICHIOMETRY re55 249
left: TGFbetaR I
left: BMP ligand TGFbetaR II
interaction type: HETERODIMER_ASSOCIATION
right: ligand TGFbetaR I TGFbetaR II

R Smad s238 sa89 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

Target transcripts
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re5 192
type: Stoichiometry
physical entity: pro ligand dimer
stoichiometric coefficient: 1.0

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 26
xref: PTHR13703:SF45
xref: uniprot O62609 25
organism: Drosophila melanogaster

? s163 sa107 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re42 226
type: Stoichiometry
physical entity: Smurf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re42 225
type: Stoichiometry
physical entity: phospho-ubiq R-Smad/Smurf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re42 227
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

uniprot P26016 71
type: UnificationXref
id: P26016
db: uniprot

HOMODIMER ID 69STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 2.0

HOMODIMER ID 17STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re5 191
type: Stoichiometry
physical entity: pro ligand dimer
stoichiometric coefficient: 1.0

TGFbetaR II
type: Protein
entity reference: TGFbetaR II
feature: TGFbetaR II s177 sa1 rs1

pro ligand dimer
type: Complex
component stoichiometry: HOMODIMER ID 80STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 53STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
component: ?
feature: COMPLEX BINDING FEATURE s160 csa5 142
feature: COMPLEX BINDING FEATURE s160 csa5 140
cellular location: unknown c3

R Smad s238 sa89 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re36 177
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

LD29161p
type: ProteinReference
xref: uniprot Q9V4F4 35
xref: PTHR11848:SF262
organism: Drosophila melanogaster

?
type: Protein

PARTICIPANT STOICHIOMETRY re36 178
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase receptor
type: ProteinReference
evidence: Evidence 9
xref: uniprot A0A0B4KG59 6
xref: PTHR23255:SF98
organism: Drosophila melanogaster

Inhibin beta chain
type: ProteinReference
xref: PTHR11848:SF178
xref: uniprot O61643 29
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Full_length__BMP_orthologous_ligand-RIGHT__BMP_orthologous_ligand-_?-_re4
controller: Furin

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s264 sa101 rs2
feature: R Smad s264 sa101 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s264 sa101 125
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__pro_ligand_dimer-RIGHT__?-_BMP_orthologous_ligand-_re6
controller: Furin

TGFbetaR I s200 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

TGFbetaR II
type: Protein
entity reference: TGFbetaR II
feature: TGFbetaR II s227 sa126 rs1

R Smad s234 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 2.0

R Smad s233 sa65 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q9W3Q1 20
type: UnificationXref
id: Q9W3Q1
db: uniprot

PARTICIPANT STOICHIOMETRY re43 220
type: Stoichiometry
physical entity: sa105_degraded
stoichiometric coefficient: 1.0

ligand/phosphoTGFbetaR I TGFbetaR II I-Smad
type: Complex
component stoichiometry: HOMODIMER ID 56STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 18STOICHIOMETRY ID COMPLEX
component stoichiometry: I Smad s255 sa99 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
component: TGFbetaR II
component: BMP orthologous ligand
component: I-Smad
component: TGFbetaR I
feature: COMPLEX BINDING FEATURE s263 csa16 108
feature: COMPLEX BINDING FEATURE s263 csa16 104
feature: COMPLEX BINDING FEATURE s263 csa16 106
feature: COMPLEX BINDING FEATURE s263 csa16 110
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re38 174
type: Stoichiometry
physical entity: ligand/phosphoTGFbetaR I TGFbetaR II
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re38 175
type: Stoichiometry
physical entity: I-Smad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re38 176
type: Stoichiometry
physical entity: ligand/phosphoTGFbetaR I TGFbetaR II I-Smad
stoichiometric coefficient: 1.0

BMP orthologous ligand s191 sa97 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s237 sa78 rs2
feature: R Smad s237 sa78 rs1

Dorsal-ventral patterning protein tolloid
type: ProteinReference
xref: uniprot P25723 22
xref: PTHR45645:SF8
organism: Drosophila melanogaster

Evidence 34
type: Evidence
evidence code: RCA
comment: Website http://flybase.org/reports/FBgn0005590.html

PTHR11254:SF395
type: RelationshipXref
id: PTHR11254:SF395
db: PANTHER Family
relationship type: By Homology

SOG
type: Protein
entity reference: SOG
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re15 209
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

TRANSPORT
type: RelationshipTypeVocabulary

TGFbetaR II
type: Protein
entity reference: TGFbetaR II
feature: TGFbetaR II s201 sa9 rs1

Evidence 31
type: Evidence
evidence code: RCA
comment: Website http://flybase.org/reports/FBgn0000490.html

PARTICIPANT STOICHIOMETRY re15 208
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re14 214
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re14 213
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 8

BMP orthologous ligand
type: Protein

R Smad s230 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

BMP orthologous ligand
type: Protein

TGFbetaR II
type: Protein
entity reference: TGFbetaR II
feature: TGFbetaR II s195 sa4 rs1

Evidence 41
type: Evidence
evidence code: RCA
comment: Website http://www.reactome.org/

Evidence 40
type: Evidence
evidence code: RCA
comment: Website http://flybase.org/reports/FBgn0011300.html

DISSOCIATION_LEFT__proDPP-RIGHT__?-_BMP_orthologous_ligand-_re56
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re56 247
participant stoichiometry: PARTICIPANT STOICHIOMETRY re56 246
participant stoichiometry: PARTICIPANT STOICHIOMETRY re56 248
left: proDPP
interaction type: DISSOCIATION
right: ?
right: BMP orthologous ligand

HOMODIMER ID 59STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re10 232
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

PARTICIPANT STOICHIOMETRY re10 233
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

HOMODIMER ID 52STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re10 234
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 235
type: Stoichiometry
physical entity: SOG/TSG DPP dimer
stoichiometric coefficient: 1.0

Smurf
type: Protein
entity reference: Smurf
feature: COMPLEX PARTICIPANT BINDING FEATURE s262 sa104 115
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SHN
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

R Smad s261 sa103 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

BMP orthologous ligand
type: Protein

TRANSPORT_LEFT__Co_Smad_phospho_R_Smad-RIGHT__Co_Smad_phospho_R_Smad-_re24
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 252
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 253
left: Co-Smad phospho R-Smad
interaction type: TRANSPORT
right: Co-Smad phospho R-Smad

BMP orthologous ligand s165 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__TGFbetaR_I-RIGHT__TGFbetaR_I-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 217
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 218
left: TGFbetaR I
interaction type: STATE_TRANSITION
right: TGFbetaR I

PARTICIPANT STOICHIOMETRY re12 224
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

R Smad s261 sa103 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re12 222
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re12 223
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Co_Smad-RIGHT__Co_Smad-_re33
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 180
left: Co-Smad
interaction type: TRANSPORT
right: Co-Smad

PARTICIPANT STOICHIOMETRY re12 221
type: Stoichiometry
physical entity: SOG/TSG DPP dimer
stoichiometric coefficient: 1.0

Co-Smad
type: Protein
entity reference: Co-Smad
feature: COMPLEX PARTICIPANT BINDING FEATURE s248 sa79 137
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__BMP_orthologous_ligand-_TGFbetaR_I-RIGHT__BMP_ligand_TGFbetaR_I-_re1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 211
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 212
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 210
left: TGFbetaR I
left: BMP orthologous ligand
interaction type: HETERODIMER_ASSOCIATION
right: BMP ligand TGFbetaR I

HOMODIMER ID 49STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

BMP orthologous ligand
type: Protein

Evidence 26
type: Evidence
evidence code: RCA
comment: Website http://flybase.org/reports/FBgn0011655.html

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PTHR13808:SF1
type: RelationshipXref
id: PTHR13808:SF1
db: PANTHER Family
relationship type: By Homology

Evidence 24
type: Evidence
evidence code: RCA
comment: Website http://flybase.org/reports/FBgn0029006.html

phosphoR-Smad Smurf
type: Complex
component stoichiometry: R Smad s264 sa101 STOICHIOMETRY ID COMPLEX
component stoichiometry: Smurf s259 sa102 STOICHIOMETRY ID COMPLEX
component: R-Smad
component: Smurf
feature: COMPLEX BINDING FEATURE s265 csa17 126
feature: COMPLEX BINDING FEATURE s265 csa17 124
cellular location: cytosol

R Smad s229 sa44 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PTHR12312:SF16
type: RelationshipXref
id: PTHR12312:SF16
db: PANTHER Family
relationship type: By Homology

HOMODIMER ID 14STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

TGFbetaR I s190 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

HOMODIMER ID 68STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__R_Smad-RIGHT__R_Smad-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 258
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 257
left: R-Smad
interaction type: STATE_TRANSITION
right: R-Smad

By Homology
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__phosphoR_Smad_Smurf-RIGHT__phospho_ubiq_R_Smad_Smurf-_re41
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 231
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 230
left: phosphoR-Smad Smurf
interaction type: STATE_TRANSITION
right: phospho-ubiq R-Smad/Smurf

uniprot O61643 29
type: UnificationXref
id: O61643
db: uniprot

PARTICIPANT STOICHIOMETRY re19 188
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re19 189
type: Stoichiometry
physical entity: ligand/phosphoTGFbetaR I TGFbetaR II phosphoR-Smad
stoichiometric coefficient: 1.0

Evidence 77
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0086361.html

PARTICIPANT STOICHIOMETRY re19 187
type: Stoichiometry
physical entity: ligand/phosphoTGFbetaR I TGFbetaR II R-Smad
stoichiometric coefficient: 1.0

PTHR23255:SF63
type: RelationshipXref
id: PTHR23255:SF63
db: PANTHER Family
relationship type: By Homology

Full-length BMP orthologous ligand
type: ProteinReference
xref: P06256
standard name: BMP/activin orthologous ligands
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.Full_minus_length _br_BMP orthologous_br_ligand
member entity reference: Protein decapentaplegic
member entity reference: LD29161p
member entity reference: Inhibin beta chain
member entity reference: Dawdle, isoform A
member entity reference: Protein screw
member entity reference: Protein 60A

proDPP
type: Complex
component stoichiometry: HOMODIMER ID 52STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 81STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
component: ?
feature: COMPLEX BINDING FEATURE s164 csa19 162
feature: COMPLEX BINDING FEATURE s164 csa19 164

R Smad s229 sa44 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

I Smad s255 sa99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: I-Smad
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Co_Smad-_R_Smad-RIGHT__R_Smad-_Co_Smad_phospho_R_Smad-_re40
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 236
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 237
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 239
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 238
left: R-Smad
left: Co-Smad
interaction type: STATE_TRANSITION
right: R-Smad
right: Co-Smad phospho R-Smad

TGFbetaR II s201 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

HOMODIMER ID 70STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 2.0

HOMODIMER ID 61STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

HOMODIMER ID 48STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

TLD
type: ProteinReference
xref: P06249
standard name: tolloid
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.TLD
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dorsal-ventral patterning protein tolloid

R Smad s231 sa58 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR23255:SF72
type: RelationshipXref
id: PTHR23255:SF72
db: PANTHER Family
relationship type: By Homology

R Smad s237 sa78 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 2.0

HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

PTHR23255:SF71
type: RelationshipXref
id: PTHR23255:SF71
db: PANTHER Family
relationship type: By Homology

Target genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Evidence 74
type: Evidence
evidence code: RCA
comment: Website http://flybase.org/reports/FBgn0020493.html

DISSOCIATION
type: InteractionVocabulary

uniprot P54356 75
type: UnificationXref
id: P54356
db: uniprot

R Smad s264 sa101 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

Full-length BMP orthologous ligand
type: Protein
entity reference: Full-length BMP orthologous ligand

PARTICIPANT STOICHIOMETRY re46 207
type: Stoichiometry
physical entity: ligand TGFbetaR I TGFbetaR II
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re46 205
type: Stoichiometry
physical entity: BMP ligand TGFbetaR I
stoichiometric coefficient: 1.0

PDP
type: Protein
entity reference: PDP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re46 206
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

PDP
type: ProteinReference
xref: P06248
standard name: pyruvate dehydrogenase phosphatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.PDP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: GM14286p

NEJ
type: Protein
entity reference: NEJ
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION_LEFT__Co_Smad_phospho_R_Smad-RIGHT__Co_Smad-_R_Smad-_re32
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 181
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 182
left: Co-Smad phospho R-Smad
interaction type: DISSOCIATION
right: Co-Smad
right: R-Smad

R Smad s231 sa58 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

ligand/phosphoTGFbetaR I TGFbetaR II
type: Complex
component stoichiometry: HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 44STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 59STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
component: TGFbetaR I
component: TGFbetaR II
feature: COMPLEX BINDING FEATURE s202 csa3 88
feature: COMPLEX BINDING FEATURE s202 csa3 86
feature: COMPLEX BINDING FEATURE s202 csa3 84
cellular location: cytosol

TGFbetaR I
type: Protein
entity reference: TGFbetaR I
feature: TGFbetaR I s176 sa96 rs1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_R_Smad-_ATP-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_phosphoR_Smad-_ADP-_re19
controller: TGFbetaR I

TGFbetaR I
type: Protein
entity reference: TGFbetaR I
feature: TGFbetaR I s190 sa56 rs1

NEJ
type: ProteinReference
xref: P06246
standard name: nejire
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.NEJ
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Nejire, isoform C

uniprot Q9V853 23
type: UnificationXref
id: Q9V853
db: uniprot

HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

BMP orthologous ligand s155 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

Co-Smad
type: Protein
entity reference: Co-Smad
feature: COMPLEX PARTICIPANT BINDING FEATURE s247 sa76 101
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Co-Smad
type: ProteinReference
xref: P06254
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.Co_minus_Smad
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mothers against decapentaplegic homolog

PARTICIPANT STOICHIOMETRY re16 203
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re16 204
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ligand_TGFbetaR_I_TGFbetaR_II-_ATP-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II-_ADP-_re3
controller: TGFbetaR II

uniprot Q961C5 76
type: UnificationXref
id: Q961C5
db: uniprot

sa105_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s231 sa58 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s231 sa58 159
feature: R Smad s231 sa58 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BMP orthologous ligand
type: Protein

BMP orthologous ligand s226 sa124 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

Protein 60A
type: ProteinReference
xref: PTHR11848:SF263
xref: uniprot P27091 32
organism: Drosophila melanogaster

TGFbetaR I s176 sa96 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

NEJ
type: Protein
entity reference: NEJ
feature: COMPLEX PARTICIPANT BINDING FEATURE s115 sa81 139
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

SHN
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s109 sa77 103
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TGFbetaR II s181 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

Evidence 9
type: Evidence
evidence code: RCA
comment: Website http://flybase.org/reports/FBgn0003169.html

SHN/MED/ phosphoMAD
type: Complex
component stoichiometry: SHN s109 sa77 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 68STOICHIOMETRY ID COMPLEX
component stoichiometry: Co Smad s247 sa76 STOICHIOMETRY ID COMPLEX
component: Co-Smad
component: SHN
component: R-Smad
feature: COMPLEX BINDING FEATURE s110 csa14 100
feature: COMPLEX BINDING FEATURE s110 csa14 98
feature: COMPLEX BINDING FEATURE s110 csa14 102
cellular location: nucleus

TGFbetaR I s171 sa10 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

PTHR11848:SF178
type: RelationshipXref
id: PTHR11848:SF178
db: PANTHER Family
relationship type: By Homology

Dawdle, isoform A
type: ProteinReference
xref: PTHR11848:SF263
xref: uniprot Q9VQG9 36
organism: Drosophila melanogaster

R Smad s241 sa105 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re43 219
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

GO GO:0005794 2
type: UnificationXref
id: GO:0005794
db: GO

HOMODIMER ID 54STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

BMP orthologous ligand
type: Protein

PARTICIPANT STOICHIOMETRY re19 190
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 2.0

Co-Smad
type: Protein
entity reference: Co-Smad
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 58STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

TGFbetaR II s201 sa9 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.42

HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

TGFbetaR II
type: Complex
component stoichiometry: TGFbetaR II s177 sa1 STOICHIOMETRY ID COMPLEX
component: TGFbetaR II
cellular location: cytosol

uniprot P42003 64
type: UnificationXref
id: P42003
db: uniprot

TGFbetaR II
type: Complex
component stoichiometry: TGFbetaR II s181 sa43 STOICHIOMETRY ID COMPLEX
component: TGFbetaR II
cellular location: endoplasmic reticulum

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__SOG_TSG_DPP_dimer-RIGHT__BMP_orthologous_ligand-_TSG-_SOG-_re12
controller: TLD

TGFbetaR II
type: Complex
component stoichiometry: TGFbetaR II s195 sa4 STOICHIOMETRY ID COMPLEX
component: TGFbetaR II
feature: COMPLEX PARTICIPANT BINDING FEATURE s195 sa4 129
cellular location: cytosol

TGFbetaR II
type: Complex
component stoichiometry: TGFbetaR II s201 sa9 STOICHIOMETRY ID COMPLEX
component: TGFbetaR II
feature: COMPLEX PARTICIPANT BINDING FEATURE s201 sa9 85
cellular location: cytosol

STATE_TRANSITION_LEFT__R_Smad-RIGHT__sa105_degraded-_re43
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 220
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 219
left: R-Smad
interaction type: STATE_TRANSITION
right: sa105_degraded

TGFbetaR II
type: Complex
component stoichiometry: TGFbetaR II s182 sa45 STOICHIOMETRY ID COMPLEX
component: TGFbetaR II
feature: COMPLEX PARTICIPANT BINDING FEATURE s182 sa45 117
cellular location: cytosol

IDA
type: EvidenceCodeVocabulary

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 74
xref: PTHR13703:SF54
xref: uniprot Q5U110 73
organism: Drosophila melanogaster

R Smad s261 sa103 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

R Smad s235 sa75 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ligand TGFbetaR I TGFbetaR II
type: Complex
component stoichiometry: HOMODIMER ID 48STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 14STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 60STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
component: TGFbetaR II
component: TGFbetaR I
feature: COMPLEX BINDING FEATURE s199 csa1 128
feature: COMPLEX BINDING FEATURE s199 csa1 130
feature: COMPLEX BINDING FEATURE s199 csa1 132
cellular location: cytosol

?
type: Protein

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: uniprot P26016 71
xref: PTHR42884:SF3
organism: Drosophila melanogaster

eco ECO:0000501 72
type: UnificationXref
id: ECO:0000501
db: eco

Co-Smad
type: Protein
entity reference: Co-Smad
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re21 261
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 260
type: Stoichiometry
physical entity: ligand/phosphoTGFbetaR I TGFbetaR II
stoichiometric coefficient: 1.0

phospho-ubiq R-Smad/Smurf
type: Complex
component stoichiometry: Smurf s262 sa104 STOICHIOMETRY ID COMPLEX
component stoichiometry: R Smad s261 sa103 STOICHIOMETRY ID COMPLEX
component: R-Smad
component: Smurf
feature: COMPLEX BINDING FEATURE s266 csa18 114
feature: COMPLEX BINDING FEATURE s266 csa18 112
cellular location: cytosol

TGFbetaR II s182 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

TGFbetaR II
type: Protein
entity reference: TGFbetaR II
feature: TGFbetaR II s181 sa43 rs1

HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

unknown c3
type: CellularLocationVocabulary
comment: unknown

Full-length BMP orthologous ligand
type: Complex
component stoichiometry: Full length BMP orthologous ligand s159 sa13 STOICHIOMETRY ID COMPLEX
component: Full-length BMP orthologous ligand
cellular location: Golgi apparatus

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s229 sa44 rs1
feature: R Smad s229 sa44 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF72
xref: uniprot A0A0B4K7J3 38
organism: Drosophila melanogaster

?
type: Protein

HOMODIMER ID 67STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re21 259
type: Stoichiometry
physical entity: ligand/phosphoTGFbetaR I TGFbetaR II phosphoR-Smad
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__phospho_ubiq_R_Smad_Smurf-RIGHT__Smurf-_R_Smad-_re42
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 225
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 227
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 226
left: phospho-ubiq R-Smad/Smurf
interaction type: DISSOCIATION
right: R-Smad
right: Smurf

BMP orthologous ligand
type: Protein

Co-Smad phospho R-Smad
type: Complex
component stoichiometry: Co Smad s244 sa68 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 67STOICHIOMETRY ID COMPLEX
component: Co-Smad
component: R-Smad
feature: COMPLEX BINDING FEATURE s252 csa12 92
feature: COMPLEX BINDING FEATURE s252 csa12 90
cellular location: cytosol

HETERODIMER_ASSOCIATION_LEFT__BMP_orthologous_ligand-_TSG-_SOG-RIGHT__SOG_TSG_DPP_dimer-_re10
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 235
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 232
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 233
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 234
left: SOG
left: BMP orthologous ligand
left: TSG
interaction type: HETERODIMER_ASSOCIATION
right: SOG/TSG DPP dimer

HETERODIMER_ASSOCIATION_LEFT__NEJ-_Co_Smad_phospho_R_Smad-RIGHT__NEJ_MED__phosphoMAD-_re28
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 242
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 240
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 241
left: NEJ
left: Co-Smad phospho R-Smad
interaction type: HETERODIMER_ASSOCIATION
right: NEJ/MED/ phosphoMAD

BMP orthologous ligand s189 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

BMP orthologous ligand
type: Protein

uniprot P27091 32
type: UnificationXref
id: P27091
db: uniprot

BMP orthologous ligand s197 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

Smurf
type: ProteinReference
xref: P06243
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.GENERIC.Smurf
comment: ENTITY_REFERENCE_NOTES=
member entity reference: E3 ubiquitin-protein ligase Smurf1

TGFbetaR I s173 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

TGFbetaR II
type: Complex
component stoichiometry: TGFbetaR II s227 sa126 STOICHIOMETRY ID COMPLEX
component: TGFbetaR II
feature: COMPLEX PARTICIPANT BINDING FEATURE s227 sa126 173
cellular location: cytosol

HETERODIMER_ASSOCIATION_LEFT__R_Smad-_Smurf-RIGHT__phosphoR_Smad_Smurf-_re39
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 263
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 264
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 262
left: R-Smad
left: Smurf
interaction type: HETERODIMER_ASSOCIATION
right: phosphoR-Smad Smurf

TGFbetaR II
type: Complex
component stoichiometry: TGFbetaR II s188 sa95 STOICHIOMETRY ID COMPLEX
component: TGFbetaR II
feature: COMPLEX PARTICIPANT BINDING FEATURE s188 sa95 107
cellular location: cytosol

Co Smad s244 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Co-Smad
stoichiometric coefficient: 1.0

HOMODIMER ID 55STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

TGFbetaR II
type: Complex
component stoichiometry: TGFbetaR II s183 sa55 STOICHIOMETRY ID COMPLEX
component: TGFbetaR II
feature: COMPLEX PARTICIPANT BINDING FEATURE s183 sa55 155
cellular location: cytosol

R Smad s235 sa75 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

R Smad s231 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

uniprot A0A0B4KG59 6
type: UnificationXref
id: A0A0B4KG59
db: uniprot

? s35 sa109 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s155 sa36 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s155 sa36 149

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s154 sa20 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s154 sa20 143
cellular location: unknown c3

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s189 sa7 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s189 sa7 105
cellular location: cytosol

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s165 sa17 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s165 sa17 145
cellular location: Golgi apparatus

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s192 sa57 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s192 sa57 123
cellular location: cytosol

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s191 sa97 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s191 sa97 161
cellular location: cytosol

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s194 sa47 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s194 sa47 89
cellular location: cytosol

R Smad s232 sa64 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Co_Smad_phospho_R_Smad-RIGHT__Co_Smad-_R_Smad-_re32
controller: PDP

HOMODIMER ID 18STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s148 sa3 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand

TGFbetaR II
type: Protein
entity reference: TGFbetaR II
feature: TGFbetaR II s188 sa95 rs1

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s241 sa105 rs1
feature: R Smad s241 sa105 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BMP ligand TGFbetaR I
type: Complex
component stoichiometry: HOMODIMER ID 49STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 61STOICHIOMETRY ID COMPLEX
component: TGFbetaR I
component: BMP orthologous ligand
feature: COMPLEX BINDING FEATURE s198 csa2 168
feature: COMPLEX BINDING FEATURE s198 csa2 166
cellular location: cytosol

TGFbetaR I s200 sa5 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

TRANSPORT_LEFT__R_Smad-RIGHT__R_Smad-_re36
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 177
left: R-Smad
interaction type: TRANSPORT
right: R-Smad

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s153 sa108 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s153 sa108 163

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s152 sa16 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
cellular location: unknown c3

BMP orthologous ligand
type: Protein

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

SOG
type: Protein
entity reference: SOG
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa37 151
comment: SPECIES_TYPE=PROTEIN

TGFbetaR I s224 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

BMP orthologous ligand s148 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

Nejire, isoform C
type: ProteinReference
xref: PTHR13808:SF1
xref: uniprot M9MS40 27
organism: Drosophila melanogaster

STATE_TRANSITION
type: InteractionVocabulary

GM14286p
type: ProteinReference
xref: uniprot Q9W3Q1 20
xref: PTHR13832:SF571
organism: Drosophila melanogaster

TRANSPORT
type: InteractionVocabulary

BMP_signaling_pathway-drosophila
type: Pathway
pathway component: TRANSPORT_LEFT__Co_Smad_phospho_R_Smad-RIGHT__Co_Smad_phospho_R_Smad-_re24
pathway component: TRANSPORT_LEFT__TGFbetaR_II-RIGHT__TGFbetaR_II-_re16
pathway component: TRANSPORT_LEFT__Co_Smad-RIGHT__Co_Smad-_re33
pathway component: STATE_TRANSITION_LEFT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_R_Smad-_ATP-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_phosphoR_Smad-_ADP-_re19
pathway component: DISSOCIATION_LEFT__phospho_ubiq_R_Smad_Smurf-RIGHT__Smurf-_R_Smad-_re42
pathway component: TRUNCATION_LEFT__pro_ligand_dimer-RIGHT__?-_BMP_orthologous_ligand-_re6
pathway component: TRANSPORT_LEFT__pro_ligand_dimer-RIGHT__proDPP-_re44
pathway component: STATE_TRANSITION_LEFT__Co_Smad-_R_Smad-RIGHT__R_Smad-_Co_Smad_phospho_R_Smad-_re40
pathway component: TRANSPORT_LEFT__R_Smad-RIGHT__R_Smad-_re36
pathway component: STATE_TRANSITION_LEFT__ligand_TGFbetaR_I_TGFbetaR_II-_ATP-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II-_ADP-_re3
pathway component: HETERODIMER_ASSOCIATION_LEFT__BMP_orthologous_ligand-_TGFbetaR_I-RIGHT__BMP_ligand_TGFbetaR_I-_re1
pathway component: DISSOCIATION_LEFT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_phosphoR_Smad-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II-_R_Smad-_re21
pathway component: STATE_TRANSITION_LEFT__phosphoR_Smad_Smurf-RIGHT__phospho_ubiq_R_Smad_Smurf-_re41
pathway component: DISSOCIATION_LEFT__Co_Smad_phospho_R_Smad-RIGHT__Co_Smad-_R_Smad-_re32
pathway component: DISSOCIATION_LEFT__SOG_TSG_DPP_dimer-RIGHT__BMP_orthologous_ligand-_TSG-_SOG-_re12
pathway component: HETERODIMER_ASSOCIATION_LEFT__BMP_ligand_TGFbetaR_II-_TGFbetaR_I-RIGHT__ligand_TGFbetaR_I_TGFbetaR_II-_re55
pathway component: HETERODIMER_ASSOCIATION_LEFT__SHN-_Co_Smad_phospho_R_Smad-RIGHT__SHN_MED__phosphoMAD-_re26
pathway component: HETERODIMER_ASSOCIATION_LEFT__BMP_orthologous_ligand-_TSG-_SOG-RIGHT__SOG_TSG_DPP_dimer-_re10
pathway component: HETERODIMER_ASSOCIATION_LEFT__R_Smad-_Smurf-RIGHT__phosphoR_Smad_Smurf-_re39
pathway component: STATE_TRANSITION_LEFT__TGFbetaR_II-RIGHT__TGFbetaR_II-_re15
pathway component: HETERODIMER_ASSOCIATION_LEFT__BMP_ligand_TGFbetaR_I-_TGFbetaR_II-RIGHT__ligand_TGFbetaR_I_TGFbetaR_II-_re46
pathway component: TRUNCATION_LEFT__Full_length__BMP_orthologous_ligand-RIGHT__BMP_orthologous_ligand-_?-_re4
pathway component: HETERODIMER_ASSOCIATION_LEFT__BMP_orthologous_ligand-_TGFbetaR_II-RIGHT__BMP_ligand_TGFbetaR_II-_re54
pathway component: TRANSPORT_LEFT__BMP_orthologous_ligand-RIGHT__BMP_orthologous_ligand-_re11
pathway component: TRANSPORT_LEFT__TGFbetaR_I-RIGHT__TGFbetaR_I-_re14
pathway component: STATE_TRANSITION_LEFT__R_Smad-RIGHT__R_Smad-_re22
pathway component: HETERODIMER_ASSOCIATION_LEFT__R_Smad-_ligand_phosphoTGFbetaR_I_TGFbetaR_II-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_R_Smad-_re17
pathway component: TRANSPORT_LEFT__pro_ligand_dimer-RIGHT__pro_ligand_dimer-_re5
pathway component: HETERODIMER_ASSOCIATION_LEFT__NEJ-_Co_Smad_phospho_R_Smad-RIGHT__NEJ_MED__phosphoMAD-_re28
pathway component: DISSOCIATION_LEFT__proDPP-RIGHT__?-_BMP_orthologous_ligand-_re56
pathway component: HETERODIMER_ASSOCIATION_LEFT__ligand_phosphoTGFbetaR_I_TGFbetaR_II-_I_Smad-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_I_Smad-_re38
pathway component: STATE_TRANSITION_LEFT__TGFbetaR_I-RIGHT__TGFbetaR_I-_re13
pathway component: STATE_TRANSITION_LEFT__R_Smad-RIGHT__sa105_degraded-_re43
xref: PANTHER Pathway P06211 1
comment: MODEL_NOTES=

TGFbetaR I
type: Complex
component stoichiometry: TGFbetaR I s174 sa46 STOICHIOMETRY ID COMPLEX
component: TGFbetaR I
feature: COMPLEX PARTICIPANT BINDING FEATURE s174 sa46 119
cellular location: cytosol

TGFbetaR I
type: Complex
component stoichiometry: TGFbetaR I s171 sa10 STOICHIOMETRY ID COMPLEX
component: TGFbetaR I
feature: COMPLEX PARTICIPANT BINDING FEATURE s171 sa10 87
cellular location: cytosol

TGFbetaR I
type: Complex
component stoichiometry: TGFbetaR I s173 sa41 STOICHIOMETRY ID COMPLEX
component: TGFbetaR I
cellular location: endoplasmic reticulum

TRUNCATION
type: InteractionVocabulary

TGFbetaR I
type: Complex
component stoichiometry: TGFbetaR I s168 sa2 STOICHIOMETRY ID COMPLEX
component: TGFbetaR I
cellular location: cytosol

TGFbetaR I
type: Complex
component stoichiometry: TGFbetaR I s224 sa8 STOICHIOMETRY ID COMPLEX
component: TGFbetaR I
feature: COMPLEX PARTICIPANT BINDING FEATURE s224 sa8 169
cellular location: cytosol

TGFbetaR I
type: Complex
component stoichiometry: TGFbetaR I s200 sa5 STOICHIOMETRY ID COMPLEX
component: TGFbetaR I
feature: COMPLEX PARTICIPANT BINDING FEATURE s200 sa5 131
cellular location: cytosol

TGFbetaR I
type: Complex
component stoichiometry: TGFbetaR I s190 sa56 STOICHIOMETRY ID COMPLEX
component: TGFbetaR I
feature: COMPLEX PARTICIPANT BINDING FEATURE s190 sa56 157
cellular location: cytosol

TGFbetaR I
type: Complex
component stoichiometry: TGFbetaR I s176 sa96 STOICHIOMETRY ID COMPLEX
component: TGFbetaR I
feature: COMPLEX PARTICIPANT BINDING FEATURE s176 sa96 109
cellular location: cytosol

TGFbetaR I
type: Protein
entity reference: TGFbetaR I
feature: TGFbetaR I s171 sa10 rs1

R Smad s232 sa64 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

TGFbetaR I s224 sa8 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

TLD
type: Protein
entity reference: TLD
comment: SPECIES_TYPE=PROTEIN

Co-Smad
type: Protein
entity reference: Co-Smad
feature: COMPLEX PARTICIPANT BINDING FEATURE s244 sa68 93
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Smurf s259 sa102 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Smurf
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__pro_ligand_dimer-RIGHT__pro_ligand_dimer-_re5
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 192
left: pro ligand dimer
interaction type: TRANSPORT
right: pro ligand dimer

BMP orthologous ligand s194 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

Protein screw
type: ProteinReference
evidence: Evidence 34
xref: PTHR11848:SF263
xref: uniprot P54631 33
organism: Drosophila melanogaster

TGFbetaR II s183 sa55 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.42

?
type: Complex
component stoichiometry: ? s163 sa107 STOICHIOMETRY ID COMPLEX
component: ?

E3 ubiquitin-protein ligase Smurf1
type: ProteinReference
evidence: Evidence 24
xref: uniprot Q9V853 23
xref: PTHR11254:SF395
organism: Drosophila melanogaster

?
type: Complex
component stoichiometry: ? s27 sa15 STOICHIOMETRY ID COMPLEX
component: ?
cellular location: unknown c3

BMP orthologous ligand s223 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

TGFbetaR II s183 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TGFbetaR II
stoichiometric coefficient: 2.0

R-Smad
type: Complex
component stoichiometry: R Smad s250 sa70 STOICHIOMETRY ID COMPLEX
component: R-Smad
feature: COMPLEX PARTICIPANT BINDING FEATURE s250 sa70 95
cellular location: nucleus

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

uniprot M9PE88 11
type: UnificationXref
id: M9PE88
db: uniprot

TGFbetaR I
type: ProteinReference
xref: P06241
standard name: TGF-beta receptor type I
comment: ENTITY_REFERENCE_ID_DESC=BMP_signaling_pathway-drosophila.PROTEIN.RECEPTOR.TGF_beta_R I
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 28

uniprot M9MS40 27
type: UnificationXref
id: M9MS40
db: uniprot

PARTICIPANT STOICHIOMETRY re41 230
type: Stoichiometry
physical entity: phosphoR-Smad Smurf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re41 231
type: Stoichiometry
physical entity: phospho-ubiq R-Smad/Smurf
stoichiometric coefficient: 1.0

R-Smad
type: Complex
component stoichiometry: R Smad s237 sa78 STOICHIOMETRY ID COMPLEX
component: R-Smad
feature: COMPLEX PARTICIPANT BINDING FEATURE s237 sa78 135
cellular location: nucleus

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

R-Smad
type: Complex
component stoichiometry: R Smad s235 sa75 STOICHIOMETRY ID COMPLEX
component: R-Smad
feature: COMPLEX PARTICIPANT BINDING FEATURE s235 sa75 99
cellular location: nucleus

R-Smad
type: Complex
component stoichiometry: R Smad s234 sa66 STOICHIOMETRY ID COMPLEX
component: R-Smad
feature: COMPLEX PARTICIPANT BINDING FEATURE s234 sa66 91
cellular location: cytosol

R-Smad
type: Protein
entity reference: R-Smad
feature: R Smad s234 sa66 rs1
feature: R Smad s234 sa66 rs2

R-Smad
type: Complex
component stoichiometry: R Smad s233 sa65 STOICHIOMETRY ID COMPLEX
component: R-Smad
cellular location: cytosol

TGFbetaR II s195 sa4 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.42

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s226 sa124 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s226 sa124 171
cellular location: cytosol

TGFbetaR II
type: Protein
entity reference: TGFbetaR II
feature: TGFbetaR II s180 sa42 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s223 sa6 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s223 sa6 167
cellular location: cytosol

BMP orthologous ligand
type: Complex
component stoichiometry: BMP orthologous ligand s197 sa11 STOICHIOMETRY ID COMPLEX
component: BMP orthologous ligand
feature: COMPLEX PARTICIPANT BINDING FEATURE s197 sa11 133
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re1 210
type: Stoichiometry
physical entity: BMP orthologous ligand
stoichiometric coefficient: 2.0

TGFbetaR I s174 sa46 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

PARTICIPANT STOICHIOMETRY re28 240
type: Stoichiometry
physical entity: NEJ
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 196
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 241
type: Stoichiometry
physical entity: Co-Smad phospho R-Smad
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 197
type: Stoichiometry
physical entity: ligand/phosphoTGFbetaR I TGFbetaR II
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 242
type: Stoichiometry
physical entity: NEJ/MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 198
type: Stoichiometry
physical entity: ligand/phosphoTGFbetaR I TGFbetaR II R-Smad
stoichiometric coefficient: 1.0

R Smad s250 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 2.0

DISSOCIATION_LEFT__ligand_phosphoTGFbetaR_I_TGFbetaR_II_phosphoR_Smad-RIGHT__ligand_phosphoTGFbetaR_I_TGFbetaR_II-_R_Smad-_re21
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 260
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 259
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 261
left: ligand/phosphoTGFbetaR I TGFbetaR II phosphoR-Smad
interaction type: DISSOCIATION
right: R-Smad
right: ligand/phosphoTGFbetaR I TGFbetaR II

PARTICIPANT STOICHIOMETRY re1 212
type: Stoichiometry
physical entity: BMP ligand TGFbetaR I
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 211
type: Stoichiometry
physical entity: TGFbetaR I
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re39 263
type: Stoichiometry
physical entity: Smurf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re39 264
type: Stoichiometry
physical entity: phosphoR-Smad Smurf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re39 262
type: Stoichiometry
physical entity: R-Smad
stoichiometric coefficient: 1.0

ncbitaxon 7227 7
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot P25723 22
type: UnificationXref
id: P25723
db: uniprot

Alphabet, isoform E
type: ProteinReference
evidence: Evidence 77
xref: PTHR47992:SF25
xref: uniprot Q961C5 76
organism: Drosophila melanogaster