uniprot P48025 222
type: UnificationXref
id: P48025
db: uniprot

uniprot F6SV58 121
type: UnificationXref
id: F6SV58
db: uniprot

MEKK
type: Protein
entity reference: MEKK
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa53 538
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Calmodulin
type: ProteinReference
xref: uniprot P62152 139
organism: Drosophila melanogaster

Calmodulin
type: ProteinReference
xref: uniprot P62149 138
xref: PTHR23050:SF424
organism: Gallus gallus

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF92
xref: uniprot F7BKT0 420
organism: Ornithorhynchus anatinus

uniprot H2R453 94
type: UnificationXref
id: H2R453
db: uniprot

Ig-alpha
type: Protein
entity reference: Ig-alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa5 486
feature: Y Ig alpha s41 sa5 rs1
feature: Y Ig alpha s41 sa5 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot A0A452DI16 202
organism: Bos taurus

uniprot H2Q867 350
type: UnificationXref
id: H2Q867
db: uniprot

uniprot Q0VD16 236
type: UnificationXref
id: Q0VD16
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__CD22-_SHP_1-RIGHT__Complex__SHP_1_CD22_-_r32
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 655
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 656
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 654
left: CD22
left: SHP-1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SHP-1/CD22)

uniprot F1P630 436
type: UnificationXref
id: F1P630
db: uniprot

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s322 sa30 566
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P28867 85
type: UnificationXref
id: P28867
db: uniprot

uniprot E2RQM0 303
type: UnificationXref
id: E2RQM0
db: uniprot

ncbitaxon 9615 19
type: UnificationXref
id: 9615
db: ncbitaxon

Calmodulin
type: ProteinReference
xref: PTHR23050:SF381
xref: uniprot P62157 141
organism: Bos taurus

NF-kappa-B inhibitor-like protein 1
type: ProteinReference
xref: PTHR15263:SF1
xref: uniprot Q8R2H1 357
organism: Rattus norvegicus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 31

Uncharacterized protein
type: ProteinReference
xref: PTHR45818:SF1
xref: uniprot F7BD31 22
organism: Macaca mulatta

STATE_TRANSITION_LEFT__BLNK-_ATP-RIGHT__ADP-_BLNK-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 601
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 603
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 602
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 600
left: BLNK
left: ATP
interaction type: STATE_TRANSITION
right: BLNK
right: ADP

jun
type: Protein
entity reference: jun
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa49 506
feature: jun s19 sa49 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P28482 64
xref: PTHR24055:SF203
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r80 576
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r80 575
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r86
control type: ACTIVATION
controller: IP3R

Complex (Ras/GDP )
type: Complex
component stoichiometry: Ras s12 sa36 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s15 sa37 STOICHIOMETRY ID COMPLEX
component: GDP
component: Ras
feature: COMPLEX BINDING FEATURE s127 a228 495
feature: COMPLEX BINDING FEATURE s127 a228 493
cellular location: cytosol

uniprot Q61831 452
type: UnificationXref
id: Q61831
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 54
organism: Canis lupus familiaris

uniprot P48455 292
type: UnificationXref
id: P48455
db: uniprot

IP3
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa41 546
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Y Ig alpha s45 sa8 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig alpha s45 sa8 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=5.590543463970282

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

uniprot F1PSC8 219
type: UnificationXref
id: F1PSC8
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F1Q118 174
organism: Canis lupus familiaris

uniprot A0A3Q1M353 201
type: UnificationXref
id: A0A3Q1M353
db: uniprot

Tyrosine-protein kinase BTK
type: ProteinReference
xref: PTHR24418:SF92
xref: uniprot P35991 422
organism: Mus musculus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 63
organism: Homo sapiens

jun s143 a258 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 296

uniprot K7ALD7 157
type: UnificationXref
id: K7ALD7
db: uniprot

uniprot H9FU38 403
type: UnificationXref
id: H9FU38
db: uniprot

STATE_TRANSITION_LEFT__CD45-RIGHT__CD45-_r79
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 595
participant stoichiometry: PARTICIPANT STOICHIOMETRY r79 596
left: CD45
interaction type: STATE_TRANSITION
right: CD45

Y Ig alpha s45 sa8 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig alpha s45 sa8 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.688003571211971
comment: MODIFICATION_RESIDUE_NAME=Y

NRAS protein
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot A5D7R9 153
organism: Bos taurus

Btk s60 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Btk
stoichiometric coefficient: 1.0

uniprot Q0JNS6 142
type: UnificationXref
id: Q0JNS6
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q01986 234
xref: PTHR48013:SF5
organism: Rattus norvegicus

uniprot P62993 72
type: UnificationXref
id: P62993
db: uniprot

uniprot A0A1D5QLW6 300
type: UnificationXref
id: A0A1D5QLW6
db: uniprot

Calmodulin
type: ProteinReference
xref: uniprot E9H5Z2 119
organism: Daphnia pulex

STATE_TRANSITION_LEFT__Complex__Rac_GDP_-_GTP-RIGHT__Complex__Rac_GTP_-_GDP-_r57
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 667
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 669
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 668
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 666
left: GTP
left: Complex (Rac/GDP)
interaction type: STATE_TRANSITION
right: Complex (Rac/GTP)
right: GDP

uniprot A8WPJ8 103
type: UnificationXref
id: A8WPJ8
db: uniprot

Evidence 213
type: Evidence
evidence code: IGI
comment: SPACC P11345

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q9Z1L0 347
organism: Rattus norvegicus

CD19
type: Protein
entity reference: CD19
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa67 498
feature: Y CD19 s69 sa67 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 sa40 544
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Evidence 217
type: Evidence
evidence code: IGI
comment: SPACC Q99N57

T ERK s133 a245 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T ERK s133 a245 rs1 T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CD45 s275 a317 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD45
stoichiometric coefficient: 2.0

Protein CBR-CMD-1
type: ProteinReference
xref: uniprot A8WPJ8 103
organism: Caenorhabditis briggsae

vav
type: Protein
entity reference: vav
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa57 570
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Rac family small GTPase 3a
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot Q6DGB7 273
organism: Danio rerio

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot F1NYZ2 226
xref: PTHR48013:SF8
organism: Gallus gallus

Evidence 208
type: Evidence
evidence code: IGI
comment: SPACC P04049

Complex (mIgM/Ig-alpha/ Ig-beta/Blk/ Btk/Lyn/ Syk)
type: Complex
component stoichiometry: Blk s59 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ig alpha s54 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: Btk s60 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ig beta s58 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: Syk s62 sa20 STOICHIOMETRY ID COMPLEX
component stoichiometry: Lyn s61 sa19 STOICHIOMETRY ID COMPLEX
component: Ig-alpha
component: Btk
component: Ig-beta
component: mIgM
component: Syk
component: Blk
component: Lyn
feature: COMPLEX BINDING FEATURE s53 a85 521
feature: COMPLEX BINDING FEATURE s53 a85 529
feature: COMPLEX BINDING FEATURE s53 a85 527
feature: COMPLEX BINDING FEATURE s53 a85 525
feature: COMPLEX BINDING FEATURE s53 a85 531
feature: COMPLEX BINDING FEATURE s53 a85 523
feature: COMPLEX BINDING FEATURE s53 a85 533
cellular location: cytosol

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot E2RKR0 377
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__Complex__mIgM_Ig_alpha__Ig_beta_-_ATP-RIGHT__ADP-_Complex__mIgM_Ig_alpha__Ig_beta_-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 585
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 583
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 586
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 584
left: Complex (mIgM/Ig-alpha/ Ig-beta)
left: ATP
interaction type: STATE_TRANSITION
right: Complex (mIgM/Ig-alpha/ Ig-beta)
right: ADP

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot A0A3Q2TY19 434
organism: Gallus gallus

NRAS isoform 1
type: ProteinReference
xref: uniprot H2PZQ7 156
xref: PTHR24070:SF189
organism: Pan troglodytes

uniprot Q9R0C8 34
type: UnificationXref
id: Q9R0C8
db: uniprot

ncbitaxon 3702 137
type: UnificationXref
id: 3702
db: ncbitaxon

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7DUD6 329
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

uniprot Q8BTI9 345
type: UnificationXref
id: Q8BTI9
db: uniprot

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 259
xref: PTHR24055:SF110
organism: Pan troglodytes

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot E2RL20 204
xref: PTHR44329:SF55
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r4 597
type: Stoichiometry
physical entity: Lyn
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 598
type: Stoichiometry
physical entity: Lyn
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 599
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 67
organism: Mus musculus

ncbitaxon 10090 31
type: UnificationXref
id: 10090
db: ncbitaxon

mIgM
type: Protein
entity reference: mIgM
feature: ACTIVE 5

uniprot F1P859 173
type: UnificationXref
id: F1P859
db: uniprot

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot G3V926 381
organism: Rattus norvegicus

uniprot Q66JE6 240
type: UnificationXref
id: Q66JE6
db: uniprot

uniprot H2QLZ4 401
type: UnificationXref
id: H2QLZ4
db: uniprot

uniprot W4XNQ0 150
type: UnificationXref
id: W4XNQ0
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot A0A2I3SSC7 390
organism: Pan troglodytes

uniprot P07948 95
type: UnificationXref
id: P07948
db: uniprot

Y BLNK s27 sa56 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s27 sa56 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.95137622615996

uniprot A0A3Q1MHG9 218
type: UnificationXref
id: A0A3Q1MHG9
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot H2QDN0 44
xref: PTHR24361:SF656
organism: Pan troglodytes

uniprot A0A1D5PXC6 431
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

uniprot Q503B6 162
type: UnificationXref
id: Q503B6
db: uniprot

B-cell receptor CD22
type: ProteinReference
xref: PTHR46958:SF1
xref: uniprot P20273 298
organism: Homo sapiens

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F7BWW9 178
xref: PTHR23113:SF168
organism: Ornithorhynchus anatinus

uniprot E2RML9 349
type: UnificationXref
id: E2RML9
db: uniprot

IKK
type: ProteinReference
xref: P00397
standard name: Inhibitor of kappa-B kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.IKK
comment: ENTITY_REFERENCE_NOTES=Long Name: IKK Synonym: IKBK,Inhibitor of Kappa B kinase Accession: P00397
member entity reference: Inhibitor of nuclear factor kappa B kinase subunit beta
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit beta
member entity reference: Conserved helix-loop-helix ubiquitous kinase
member entity reference: Inhibitor of nuclear factor kappa-B kinase subunit alpha
member entity reference: Uncharacterized protein

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9031 7
type: UnificationXref
id: 9031
db: ncbitaxon

00696
type: UnificationXref
id: MOD:00696
db: mod

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF383
xref: uniprot J9NXY2 128
organism: Canis lupus familiaris

Y BLNK s27 sa56 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s27 sa56 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7583620820412538
comment: MODIFICATION_RESIDUE_NAME=Y

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 61
organism: Pan troglodytes

Ca++
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

Growth factor receptor-bound protein 2
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q60631 75
organism: Mus musculus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__BCR_responsive_genes-RIGHT__BCR_responsive_mRNA-_re50
control type: ACTIVATION
controller: Complex (fos/jun)

uniprot P36507 233
type: UnificationXref
id: P36507
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot Q99759 49
xref: PTHR24361:SF656
organism: Homo sapiens

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 106

eco ECO:0000250 12
type: UnificationXref
id: ECO:0000250
db: eco

Y BLNK s27 sa56 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s27 sa56 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.426319326209974
comment: MODIFICATION_RESIDUE_NAME=Y

VAV2 isoform 2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot A0A2I3T4A4 10
organism: Pan troglodytes

uniprot H2QAS6 80
type: UnificationXref
id: H2QAS6
db: uniprot

uniprot F7EJL2 24
type: UnificationXref
id: F7EJL2
db: uniprot

CD45
type: ProteinReference
xref: P00396
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: CD45 Synonym: Leukocyte common antigen Accession: P00396
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.CD45
member entity reference: Receptor-type tyrosine-protein phosphatase C
member entity reference: Uncharacterized protein
member entity reference: PTPRC isoform 2

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF42
xref: uniprot H2R453 94
organism: Pan troglodytes

DISSOCIATION
type: RelationshipTypeVocabulary

B-lymphocyte antigen CD19
type: ProteinReference
xref: PTHR16674:SF2
xref: uniprot P15391 364
organism: Homo sapiens

PTHR24418:SF181
type: RelationshipXref
id: PTHR24418:SF181
db: PANTHER Family
relationship type: By Homology

uniprot Q5U1Y2 272
type: UnificationXref
id: Q5U1Y2
db: uniprot

Calmodulin
type: ProteinReference
xref: uniprot E3KLJ3 117
organism: Puccinia graminis

Predicted protein
type: ProteinReference
xref: uniprot A9V8J8 108
organism: Monosiga brevicollis

uniprot A0A1D5R1G4 348
type: UnificationXref
id: A0A1D5R1G4
db: uniprot

CD79B isoform 2
type: ProteinReference
xref: uniprot H2QDN8 164
xref: PTHR14334:SF2
organism: Pan troglodytes

ncbitaxon 9606 29
type: UnificationXref
id: 9606
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6YAB9 247
organism: Monodelphis domestica

PTHR44329:SF55
type: RelationshipXref
id: PTHR44329:SF55
db: PANTHER Family
relationship type: By Homology

ATP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

MAP3K2 isoform 1
type: ProteinReference
xref: uniprot H2QIN7 45
xref: PTHR24361:SF342
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XT65 228
xref: PTHR48013:SF5
organism: Monodelphis domestica

NF-AT
type: Protein
feature: NF AT s123 a206 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot H2QS62 444
organism: Pan troglodytes

uniprot Q9CX99 76
type: UnificationXref
id: Q9CX99
db: uniprot

mIgM
type: ProteinReference
xref: P00389
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.RECEPTOR.mIgM
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Uncharacterized protein

Calmodulin
type: ProteinReference
xref: P00375
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Calmodulin
comment: ENTITY_REFERENCE_NOTES=Long Name: Calmodulin Synonym: CaM Accession: P00375
member entity reference: Calmodulin-7
member entity reference: Putative calmodulin
member entity reference: Uncharacterized protein
member entity reference: Calmodulin
member entity reference: AGAP010957-PA (Fragment)
member entity reference: Predicted protein
member entity reference: Calmodulin-1
member entity reference: Calmodulin-2
member entity reference: Calmodulin 1
member entity reference: Calmodulin-3
member entity reference: Protein CBR-CMD-1
member entity reference: Predicted protein (Fragment)

uniprot Q95KV0 387
type: UnificationXref
id: Q95KV0
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__jun-_fos-RIGHT__Complex__fos_jun_-_r50
controller: ERK

uniprot H2QS62 444
type: UnificationXref
id: H2QS62
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa62 554
feature: MEK s35 sa62 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot P20651 289
organism: Rattus norvegicus

PTHR44329:SF47
type: RelationshipXref
id: PTHR44329:SF47
db: PANTHER Family
relationship type: By Homology

uniprot Q07014 97
type: UnificationXref
id: Q07014
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A4FV00 435
xref: PTHR24055:SF162
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7CYE3 442
xref: PTHR24055:SF162
organism: Xenopus tropicalis

Calmodulin-7
type: ProteinReference
xref: uniprot P59220 136
xref: PTHR23050:SF438
organism: Arabidopsis thaliana

uniprot F1PMN2 437
type: UnificationXref
id: F1PMN2
db: uniprot

uniprot Q9WTU6 454
type: UnificationXref
id: Q9WTU6
db: uniprot

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q5RKN6 74
organism: Danio rerio

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot F6Q932 285
organism: Macaca mulatta

PLC gamma2 s65 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PLC gamma2
stoichiometric coefficient: 1.0

PTHR22969:SF7
type: RelationshipXref
id: PTHR22969:SF7
db: PANTHER Family
relationship type: By Homology

Inhibitor of nuclear factor kappa B kinase subunit beta
type: ProteinReference
xref: uniprot H2QW34 382
xref: PTHR22969:SF7
organism: Pan troglodytes

B-cell linker protein
type: ProteinReference
xref: uniprot Q8WV28 368
xref: PTHR14098:SF3
organism: Homo sapiens

uniprot F6ZCW7 399
type: UnificationXref
id: F6ZCW7
db: uniprot

uniprot F7C798 248
type: UnificationXref
id: F7C798
db: uniprot

uniprot Q8WNW7 358
type: UnificationXref
id: Q8WNW7
db: uniprot

uniprot F7BGK5 419
type: UnificationXref
id: F7BGK5
db: uniprot

uniprot O15111 384
type: UnificationXref
id: O15111
db: uniprot

Calcineurin
type: Protein
entity reference: Calcineurin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Ras_Raf__MEK_GTP_-RIGHT__Complex__Ras_GTP__Raf_-_MEK-_r75
controller: Complex (Ras/Raf/ MEK/GTP)

PARTICIPANT STOICHIOMETRY r78 605
type: Stoichiometry
physical entity: Jnk
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6USY2 42
xref: PTHR24361:SF656
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r78 604
type: Stoichiometry
physical entity: Jnk
stoichiometric coefficient: 1.0

uniprot F6V332 246
type: UnificationXref
id: F6V332
db: uniprot

uniprot J9P5W6 229
type: UnificationXref
id: J9P5W6
db: uniprot

Ras
type: ProteinReference
xref: P00376
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Ras
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: GTPase NRas
member entity reference: GTPase HRas
member entity reference: NRAS protein
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: NRAS isoform 1
member entity reference: HRAS isoform 2
member entity reference: GTPase HRas isoform 1
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s26 sa55 462
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot C3ZEW0 114
type: UnificationXref
id: C3ZEW0
db: uniprot

uniprot P48453 291
type: UnificationXref
id: P48453
db: uniprot

uniprot E2RKR0 377
type: UnificationXref
id: E2RKR0
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6RUV5 276
organism: Rattus norvegicus

uniprot Q63538 258
type: UnificationXref
id: Q63538
db: uniprot

uniprot Q60680 386
type: UnificationXref
id: Q60680
db: uniprot

uniprot Q07890 185
type: UnificationXref
id: Q07890
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A0G2K5T3 316
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot H2QW34 382
type: UnificationXref
id: H2QW34
db: uniprot

Y BLNK s27 sa56 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s27 sa56 rs4 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.528080903700913
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot A6QLK6 70
type: UnificationXref
id: A6QLK6
db: uniprot

TRANSPORT_LEFT__NF_kappa_B-RIGHT__NF_kappa_B-_r73
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 632
participant stoichiometry: PARTICIPANT STOICHIOMETRY r73 631
left: NF-kappa B
interaction type: TRANSPORT
right: NF-kappa B

uniprot A5D7R9 153
type: UnificationXref
id: A5D7R9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK-RIGHT__MEKK-_r84
controller: Complex (Rac/GTP)

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 58
organism: Monodelphis domestica

Rac family small GTPase 1b
type: ProteinReference
xref: uniprot Q29RC5 271
xref: PTHR24072:SF105
organism: Danio rerio

uniprot A9JRY8 264
type: UnificationXref
id: A9JRY8
db: uniprot

PARTICIPANT STOICHIOMETRY r74 630
type: Stoichiometry
physical entity: Complex (Ras/Raf/ MEK/GTP)
stoichiometric coefficient: 1.0

TRANSPORT
type: RelationshipTypeVocabulary

uniprot P35329 299
type: UnificationXref
id: P35329
db: uniprot

uniprot E2R2N2 53
type: UnificationXref
id: E2R2N2
db: uniprot

fos s18 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: fos
stoichiometric coefficient: 1.0

Vav guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR45818:SF2
xref: uniprot E2RGT8 18
organism: Canis lupus familiaris

uniprot Q99N57 216
type: UnificationXref
id: Q99N57
db: uniprot

uniprot A5A6H0 187
type: UnificationXref
id: A5A6H0
db: uniprot

uniprot H9EU39 81
type: UnificationXref
id: H9EU39
db: uniprot

SHP-1
type: Protein
entity reference: SHP-1
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa31 456
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Proto-oncogene vav
type: ProteinReference
xref: PTHR45818:SF2
xref: uniprot P27870 30
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r74 628
type: Stoichiometry
physical entity: Complex (Ras/GTP/ Raf)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r74 629
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Complex (fos/jun)
type: Complex
component stoichiometry: jun s19 sa49 STOICHIOMETRY ID COMPLEX
component stoichiometry: fos s18 sa48 STOICHIOMETRY ID COMPLEX
component: jun
component: fos
feature: COMPLEX BINDING FEATURE s148 a262 503
feature: COMPLEX BINDING FEATURE s148 a262 505
cellular location: nucleus

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa24 474
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r14 602
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 603
type: Stoichiometry
physical entity: BLNK
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF383
xref: uniprot F6SV58 121
organism: Monodelphis domestica

ncbitaxon 9913 17
type: UnificationXref
id: 9913
db: ncbitaxon

GDP s24 sa53 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot F1NYZ2 226
type: UnificationXref
id: F1NYZ2
db: uniprot

PARTICIPANT STOICHIOMETRY r14 600
type: Stoichiometry
physical entity: BLNK
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PR76 371
xref: PTHR19134:SF284
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r14 601
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot P48453 291
organism: Mus musculus

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot P48452 290
organism: Bos taurus

Calmodulin
type: Protein
entity reference: Calmodulin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P20273 298
type: UnificationXref
id: P20273
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 12

Y CD19 s256 a291 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y CD19 s256 a291 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR45673:SF2
xref: uniprot P48455 292
organism: Mus musculus

uniprot A7RPI8 100
type: UnificationXref
id: A7RPI8
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9Z1B7 263
xref: PTHR24055:SF107
organism: Mus musculus

Btk
type: Protein
entity reference: Btk
feature: Y Btk s300 a4 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ig alpha s45 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ig-alpha
stoichiometric coefficient: 1.0

ncbitaxon 10116 15
type: UnificationXref
id: 10116
db: ncbitaxon

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot O14920 383
xref: PTHR22969:SF7
organism: Homo sapiens

P00393
type: UnificationXref
id: P00393
db: PANTHER Pathway Component

Ig-alpha
type: Protein
entity reference: Ig-alpha
feature: ACTIVE 5
feature: Y Ig alpha s54 sa15 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa15 524
feature: Y Ig alpha s54 sa15 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P00392
type: UnificationXref
id: P00392
db: PANTHER Pathway Component

P00394
type: UnificationXref
id: P00394
db: PANTHER Pathway Component

P00397
type: UnificationXref
id: P00397
db: PANTHER Pathway Component

P00396
type: UnificationXref
id: P00396
db: PANTHER Pathway Component

uniprot P01101 193
type: UnificationXref
id: P01101
db: uniprot

P00399
type: UnificationXref
id: P00399
db: PANTHER Pathway Component

P00398
type: UnificationXref
id: P00398
db: PANTHER Pathway Component

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 25

PARTICIPANT STOICHIOMETRY r83 690
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 1.0

P00391
type: UnificationXref
id: P00391
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r83 691
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 1.0

P00390
type: UnificationXref
id: P00390
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Btk-RIGHT__ADP-_Btk-_r22
controller: Lyn

Predicted protein
type: ProteinReference
xref: uniprot A7RPI8 100
organism: Nematostella vectensis

P00389
type: UnificationXref
id: P00389
db: PANTHER Pathway Component

uniprot A9V8J8 108
type: UnificationXref
id: A9V8J8
db: uniprot

uniprot F1LWB1 20
type: UnificationXref
id: F1LWB1
db: uniprot

P00380
type: UnificationXref
id: P00380
db: PANTHER Pathway Component

uniprot P05126 82
type: UnificationXref
id: P05126
db: uniprot

NF-kappa B
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa58 540
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P00387
type: UnificationXref
id: P00387
db: PANTHER Pathway Component

uniprot P53779 450
type: UnificationXref
id: P53779
db: uniprot

P00388
type: UnificationXref
id: P00388
db: PANTHER Pathway Component

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot F6ZKB3 440
organism: Macaca mulatta

P00385
type: UnificationXref
id: P00385
db: PANTHER Pathway Component

uniprot Q60631 75
type: UnificationXref
id: Q60631
db: uniprot

P00386
type: UnificationXref
id: P00386
db: PANTHER Pathway Component

P00383
type: UnificationXref
id: P00383
db: PANTHER Pathway Component

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7G3I5 332
organism: Monodelphis domestica

P00384
type: UnificationXref
id: P00384
db: PANTHER Pathway Component

P00381
type: UnificationXref
id: P00381
db: PANTHER Pathway Component

P00382
type: UnificationXref
id: P00382
db: PANTHER Pathway Component

Predicted protein (Fragment)
type: ProteinReference
xref: uniprot A7RPN8 102
organism: Nematostella vectensis

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot F6R543 397
organism: Monodelphis domestica

uniprot P63329 294
type: UnificationXref
id: P63329
db: uniprot

uniprot A0A3Q1N7P8 391
type: UnificationXref
id: A0A3Q1N7P8
db: uniprot

P00379
type: UnificationXref
id: P00379
db: PANTHER Pathway Component

P00378
type: UnificationXref
id: P00378
db: PANTHER Pathway Component

uniprot A0A3S5ZPX3 225
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F6WV79 438
organism: Monodelphis domestica

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot A0A3Q1M353 201
organism: Bos taurus

uniprot F7CY56 125
type: UnificationXref
id: F7CY56
db: uniprot

uniprot P63085 65
type: UnificationXref
id: P63085
db: uniprot

eco ECO:0000316 8
type: UnificationXref
id: ECO:0000316
db: eco

Y CD22 s5 sa32 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y CD22 s5 sa32 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

P00374
type: UnificationXref
id: P00374
db: PANTHER Pathway Component

uniprot P05627 428
type: UnificationXref
id: P05627
db: uniprot

P00375
type: UnificationXref
id: P00375
db: PANTHER Pathway Component

P00376
type: UnificationXref
id: P00376
db: PANTHER Pathway Component

P00377
type: UnificationXref
id: P00377
db: PANTHER Pathway Component

P00371
type: UnificationXref
id: P00371
db: PANTHER Pathway Component

P00372
type: UnificationXref
id: P00372
db: PANTHER Pathway Component

P00373
type: UnificationXref
id: P00373
db: PANTHER Pathway Component

P00368
type: UnificationXref
id: P00368
db: PANTHER Pathway Component

NF-kappa-B inhibitor-like protein 1
type: ProteinReference
xref: PTHR15263:SF1
xref: uniprot O88995 351
organism: Mus musculus

P00369
type: UnificationXref
id: P00369
db: PANTHER Pathway Component

HETERODIMER_ASSOCIATION_LEFT__BLNK-_vav-RIGHT__Complex__BLNK_vav_-_r58
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 664
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 665
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 663
left: BLNK
left: vav
interaction type: HETERODIMER_ASSOCIATION
right: Complex (BLNK/vav)

uniprot P59220 136
type: UnificationXref
id: P59220
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 252
xref: PTHR24055:SF110
organism: Mus musculus

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 198
evidence: Evidence 197
evidence: Evidence 199
evidence: Evidence 196
xref: PTHR44329:SF22
xref: uniprot A0A2I3THL4 200
organism: Pan troglodytes

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 137

Y Btk s60 sa18 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Btk s60 sa18 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7GAP5 333
xref: PTHR10048:SF33
organism: Ornithorhynchus anatinus

ncbitaxon 7739 113
type: UnificationXref
id: 7739
db: ncbitaxon

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 62
organism: Rattus norvegicus

PKC
type: Protein
entity reference: PKC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r35 648
type: Stoichiometry
physical entity: NF-AT
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot A0A1D5NVQ5 6
organism: Gallus gallus

uniprot F6Y841 328
type: UnificationXref
id: F6Y841
db: uniprot

PARTICIPANT STOICHIOMETRY r35 649
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot P29995 406
xref: PTHR13715:SF53
organism: Rattus norvegicus

uniprot Q9Z1B7 263
type: UnificationXref
id: Q9Z1B7
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P29994 405
organism: Rattus norvegicus

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot F6SHC1 379
xref: PTHR22969:SF7
organism: Macaca mulatta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O00329 338
organism: Homo sapiens

Danio rerio
type: BioSource
xref: ncbitaxon 7955 69

PARTICIPANT STOICHIOMETRY r35 650
type: Stoichiometry
physical entity: NF-AT
stoichiometric coefficient: 1.0

V-type proton ATPase subunit G 2
type: ProteinReference
xref: PTHR15263:SF1
xref: uniprot Q5TM18 354
organism: Macaca mulatta

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot Q63538 258
organism: Rattus norvegicus

Ig-beta
type: ProteinReference
xref: P00377
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Ig-beta
comment: ENTITY_REFERENCE_NOTES=
member entity reference: B-cell antigen receptor complex-associated protein beta chain
member entity reference: CD79B isoform 2

Ig alpha s41 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ig-alpha
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase 3 isoform 1
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot A0A1D5QJ66 36
organism: Macaca mulatta

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot E1BKE7 393
xref: PTHR13715:SF51
organism: Bos taurus

uniprot F7CYE3 442
type: UnificationXref
id: F7CYE3
db: uniprot

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 99

NF AT s129 a241 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot D4A5Q1 320
xref: PTHR10048:SF35
organism: Rattus norvegicus

PTHR46680:SF1
type: RelationshipXref
id: PTHR46680:SF1
db: PANTHER Family
relationship type: By Homology

GRB2-related adapter protein
type: ProteinReference
xref: uniprot F7GJG7 71
organism: Macaca mulatta

uniprot P04049 207
type: UnificationXref
id: P04049
db: uniprot

uniprot A0A1D5QKD3 224
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

Ig beta s58 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ig-beta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 670
type: Stoichiometry
physical entity: Complex (BLNK/Btk/ PLC gamma2/Grb2/ SOS)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 671
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 672
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Raf
type: Protein
entity reference: Raf
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa61 552
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r24 673
type: Stoichiometry
physical entity: Complex (BLNK/PLC gamma2/ Btk/Grb2/ SOS)
stoichiometric coefficient: 1.0

uniprot Q16539 256
type: UnificationXref
id: Q16539
db: uniprot

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s321 sa29 564
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Jnk
type: Protein
entity reference: Jnk
feature: Jnk s250 a284 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa38 572
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E2RCV1 322
type: UnificationXref
id: E2RCV1
db: uniprot

IKK
type: Protein
entity reference: IKK
feature: ACTIVE 5
feature: IKK s267 a300 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

BLNK
type: Protein
entity reference: BLNK
feature: Y BLNK s318 sa26 rs3
feature: Y BLNK s318 sa26 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s318 sa26 558
feature: Y BLNK s318 sa26 rs2
feature: Y BLNK s318 sa26 rs4
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P10398 211
type: UnificationXref
id: P10398
db: uniprot

T ERK s132 a244 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T ERK s132 a244 rs1 T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF92
xref: uniprot F7BGK5 419
organism: Macaca mulatta

Putative calmodulin
type: ProteinReference
xref: uniprot A0A0D1DU81 98
organism: Ustilago maydis

uniprot A0A2I3RSP9 280
type: UnificationXref
id: A0A2I3RSP9
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 15

uniprot P52735 32
type: UnificationXref
id: P52735
db: uniprot

uniprot A0A0G2K344 315
type: UnificationXref
id: A0A0G2K344
db: uniprot

eco ECO:0000353 184
type: UnificationXref
id: ECO:0000353
db: eco

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r68
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 647
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 646
left: IKK
interaction type: STATE_TRANSITION
right: IKK

PARTICIPANT STOICHIOMETRY r7 586
type: Stoichiometry
physical entity: Complex (mIgM/Ig-alpha/ Ig-beta)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 585
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 584
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 583
type: Stoichiometry
physical entity: Complex (mIgM/Ig-alpha/ Ig-beta)
stoichiometric coefficient: 1.0

uniprot P49186 448
type: UnificationXref
id: P49186
db: uniprot

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: uniprot E1BBD2 16
xref: PTHR45818:SF1
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_jun-RIGHT__ADP-_jun-_r51
controller: Jnk

uniprot P14056 214
type: UnificationXref
id: P14056
db: uniprot

Blk s59 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Blk
stoichiometric coefficient: 1.0

I kappa B
type: Protein
entity reference: I kappa B
feature: I kappa B s265 a305 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

uniprot A9SHH7 107
type: UnificationXref
id: A9SHH7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7HLC7 334
xref: PTHR10048:SF35
organism: Macaca mulatta

uniprot F6X927 380
type: UnificationXref
id: F6X927
db: uniprot

uniprot Q8R2H1 357
type: UnificationXref
id: Q8R2H1
db: uniprot

uniprot P15530 165
type: UnificationXref
id: P15530
db: uniprot

PTHR46958:SF1
type: RelationshipXref
id: PTHR46958:SF1
db: PANTHER Family
relationship type: By Homology

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot O15111 384
xref: PTHR22969:SF13
organism: Homo sapiens

TRUNCATION
type: InteractionVocabulary

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa50 490
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P20651 289
type: UnificationXref
id: P20651
db: uniprot

uniprot Q5WR08 355
type: UnificationXref
id: Q5WR08
db: uniprot

uniprot A0A2I3T4A4 10
type: UnificationXref
id: A0A2I3T4A4
db: uniprot

Ig beta s47 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ig-beta
stoichiometric coefficient: 1.0

uniprot P48736 344
type: UnificationXref
id: P48736
db: uniprot

Syk
type: Protein
entity reference: Syk
feature: Y Syk s2 a57 rs1
feature: Y Syk s2 a57 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: uniprot Q503B6 162
xref: PTHR24070:SF423
organism: Danio rerio

uniprot F1PET4 21
type: UnificationXref
id: F1PET4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6T2A6 122
organism: Ciona intestinalis

ERK
type: Protein
entity reference: ERK
feature: ACTIVE 5
feature: T ERK s133 a245 rs1
feature: Y ERK s133 a245 rs2
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Transcription factor AP-1
type: ProteinReference
xref: uniprot P17325 429
xref: PTHR11462:SF8
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__jun-_fos-RIGHT__Complex__fos_jun_-_r50
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 701
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 702
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 700
left: jun
left: fos
interaction type: HETERODIMER_ASSOCIATION
right: Complex (fos/jun)

CD45
type: Complex
component stoichiometry: CD45 s275 a317 STOICHIOMETRY ID COMPLEX
component: CD45
cellular location: cytosol

CD45
type: Protein
entity reference: CD45

Rac
type: Protein
entity reference: Rac
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa52 536
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y Btk s49 sa11 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Btk s49 sa11 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Rac family small GTPase 3b
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot A9JRY8 264
organism: Danio rerio

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q9Z1E3 361
organism: Mus musculus

vav s30 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: vav
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r76 617
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

uniprot Q5EAC4 353
type: UnificationXref
id: Q5EAC4
db: uniprot

PARTICIPANT STOICHIOMETRY r76 616
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CRAC-RIGHT__CRAC-_r30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 659
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 660
left: CRAC
interaction type: STATE_TRANSITION
right: CRAC

uniprot F7BD31 22
type: UnificationXref
id: F7BD31
db: uniprot

uniprot Q9Z1L0 347
type: UnificationXref
id: Q9Z1L0
db: uniprot

MEK
type: ProteinReference
xref: P00383
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.MEK
comment: ENTITY_REFERENCE_NOTES=Long Name: MEK Synonym: MAP kinase kinase,MAPK/ERK Kinase Accession: P00383
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Uncharacterized protein
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase 2
member entity reference: MAP2K1 protein
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: MAP2K2 isoform 1

Btk
type: Protein
entity reference: Btk
feature: ACTIVE 5
feature: Y Btk s64 sa22 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa22 470
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r52 688
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot Q28EW2 161
type: UnificationXref
id: Q28EW2
db: uniprot

PARTICIPANT STOICHIOMETRY r52 689
type: Stoichiometry
physical entity: Complex (PKC/DAG)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r30 660
type: Stoichiometry
physical entity: CRAC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r52 687
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

uniprot A0A2I3THL4 200
type: UnificationXref
id: A0A2I3THL4
db: uniprot

PARTICIPANT STOICHIOMETRY r50 701
type: Stoichiometry
physical entity: fos
stoichiometric coefficient: 1.0

CD22
type: ProteinReference
xref: P00387
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.CD22
comment: ENTITY_REFERENCE_NOTES=Long Name: CD22 Synonym: Synonym not specified Accession: P00387
member entity reference: B-cell receptor CD22

PARTICIPANT STOICHIOMETRY r50 702
type: Stoichiometry
physical entity: Complex (fos/jun)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r50 700
type: Stoichiometry
physical entity: jun
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q63932 239
xref: PTHR48013:SF8
organism: Mus musculus

uniprot F7FHD1 59
type: UnificationXref
id: F7FHD1
db: uniprot

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa60 550
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E2QYK5 189
type: UnificationXref
id: E2QYK5
db: uniprot

Tyrosine-protein kinase Lyn
type: ProteinReference
xref: uniprot P07948 95
xref: PTHR24418:SF42
organism: Homo sapiens

Ig-beta
type: Protein
entity reference: Ig-beta
feature: Y Ig beta s42 sa6 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa6 488
feature: Y Ig beta s42 sa6 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

mIgM
type: Protein
entity reference: mIgM
feature: ACTIVE 5

PARTICIPANT STOICHIOMETRY r30 659
type: Stoichiometry
physical entity: CRAC
stoichiometric coefficient: 1.0

vav
type: Protein
entity reference: vav
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q6LC82 275
type: UnificationXref
id: Q6LC82
db: uniprot

DAG
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot F6X927 380
organism: Macaca mulatta

uniprot Q6PI52 147
type: UnificationXref
id: Q6PI52
db: uniprot

ncbitaxon 6238 104
type: UnificationXref
id: 6238
db: ncbitaxon

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__BCR_responsive_genes-RIGHT__BCR_responsive_mRNA-_re50
control type: ACTIVATION
controller: NF-kappa B

STATE_TRANSITION_LEFT__Complex__BLNK_Btk__PLC_gamma2_Grb2__SOS_-_ATP-RIGHT__ADP-_Complex__BLNK_PLC_gamma2__Btk_Grb2__SOS_-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 673
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 672
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 671
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 670
left: Complex (BLNK/Btk/ PLC gamma2/Grb2/ SOS)
left: ATP
interaction type: STATE_TRANSITION
right: Complex (BLNK/PLC gamma2/ Btk/Grb2/ SOS)
right: ADP

uniprot A0A3Q2TY19 434
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

Tyrosine-protein kinase SYK
type: ProteinReference
xref: uniprot P43405 221
xref: PTHR24418:SF231
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot F6WX28 190
organism: Monodelphis domestica

uniprot P15153 267
type: UnificationXref
id: P15153
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42336 341
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P42338 343
xref: PTHR10048:SF33
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42337 342
xref: PTHR10048:SF107
organism: Mus musculus

BLNK s63 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BLNK
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot W4YPT6 152
organism: Strongylocentrotus purpuratus

uniprot P04627 209
type: UnificationXref
id: P04627
db: uniprot

uniprot P05625 210
type: UnificationXref
id: P05625
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1P859 173
xref: PTHR23113:SF150
organism: Canis lupus familiaris

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q9Z329 412
xref: PTHR13715:SF53
organism: Mus musculus

Y Ig beta s39 sa3 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig beta s39 sa3 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.7638955247770007
comment: MODIFICATION_RESIDUE_NAME=Y

PTHR14098:SF3
type: RelationshipXref
id: PTHR14098:SF3
db: PANTHER Family
relationship type: By Homology

BLNK
type: ProteinReference
xref: P00394
comment: ENTITY_REFERENCE_NOTES=Long Name: BLNK Synonym: B Cell Linker Protein,BASH,SLP-65 Accession: P00394
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.BLNK
member entity reference: B-cell linker protein
member entity reference: Uncharacterized protein
member entity reference: B cell linker

ncbitaxon 6669 120
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot F6QUW1 175
type: UnificationXref
id: F6QUW1
db: uniprot

Calmodulin
type: ProteinReference
xref: uniprot B3RJX8 110
organism: Trichoplax adhaerens

PARTICIPANT STOICHIOMETRY r79 596
type: Stoichiometry
physical entity: CD45
stoichiometric coefficient: 1.0

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot F6W7C8 327
xref: PTHR10048:SF34
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r79 595
type: Stoichiometry
physical entity: CD45
stoichiometric coefficient: 2.0

BLNK
type: Protein
entity reference: BLNK
feature: Y BLNK s63 sa21 rs3
feature: Y BLNK s63 sa21 rs4
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 sa21 468
feature: Y BLNK s63 sa21 rs1
feature: Y BLNK s63 sa21 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r5 589
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q29RC5 271
type: UnificationXref
id: Q29RC5
db: uniprot

PARTICIPANT STOICHIOMETRY r5 587
type: Stoichiometry
physical entity: Lyn
stoichiometric coefficient: 1.0

uniprot P21708 62
type: UnificationXref
id: P21708
db: uniprot

PARTICIPANT STOICHIOMETRY r5 588
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot E2RBB8 89
type: UnificationXref
id: E2RBB8
db: uniprot

IP3R
type: ProteinReference
xref: P00398
standard name: inositol 1,4,5-triphosphate receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES=Long Name: IP3R Synonym: IP3 Receptor,Inositol (3,4,5) triphosphate Receptor Accession: P00398
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.ION_CHANNEL.IP3R
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
member entity reference: Inositol 1,4,5-trisphosphate receptor type 2
member entity reference: Uncharacterized protein
member entity reference: Inositol 1,4,5-trisphosphate receptor type 3

Raf
type: Protein
entity reference: Raf
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9UKW4 35
type: UnificationXref
id: Q9UKW4
db: uniprot

PTHR24418:SF231
type: RelationshipXref
id: PTHR24418:SF231
db: PANTHER Family
relationship type: By Homology

Y Ig beta s39 sa3 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig beta s39 sa3 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=4.865038308779955

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__BLNK-_ATP-RIGHT__ADP-_BLNK-_r14
controller: Complex (mIgM/Ig-alpha/ Ig-beta/Blk/ Btk/Lyn/ Syk)

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot P63329 294
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot P63328 293
organism: Mus musculus

mIgM
type: Complex
component stoichiometry: mIgM s40 sa4 STOICHIOMETRY ID COMPLEX
component: mIgM
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa4 484
cellular location: cytosol

CD19
type: Protein
entity reference: CD19
feature: Y CD19 s256 a291 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q61831 452
xref: PTHR24055:SF162
organism: Mus musculus

mIgM
type: Complex
component stoichiometry: mIgM s37 sa1 STOICHIOMETRY ID COMPLEX
component: mIgM
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa1 478
cellular location: cytosol

Y Lyn s61 sa19 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s61 sa19 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P63001 269
type: UnificationXref
id: P63001
db: uniprot

PARTICIPANT STOICHIOMETRY r5 590
type: Stoichiometry
physical entity: Lyn
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__NF_kappa_B_I_kappa_B_-RIGHT__NF_kappa_B-_I_kappa_B-_r67
controller: IKK

uniprot F7GJG7 71
type: UnificationXref
id: F7GJG7
db: uniprot

NF-kappa-B inhibitor-like protein 1
type: ProteinReference
xref: PTHR15263:SF1
xref: uniprot Q9UBC1 360
organism: Homo sapiens

Y Ig beta s47 sa9 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig beta s47 sa9 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.7638955247770007
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot Q9WTY9 261
type: UnificationXref
id: Q9WTY9
db: uniprot

Y BLNK s63 sa21 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s63 sa21 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.95137622615996

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q9XT09 241
xref: PTHR48013:SF5
organism: Pan troglodytes

STATE_TRANSITION_LEFT__Lyn-_ATP-RIGHT__ADP-_Lyn-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 590
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 589
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 588
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 587
left: ATP
left: Lyn
interaction type: STATE_TRANSITION
right: Lyn
right: ADP

B-cell linker protein
type: ProteinReference
xref: uniprot Q9QUN3 369
xref: PTHR14098:SF3
organism: Mus musculus

uniprot A8KBH6 77
type: UnificationXref
id: A8KBH6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot J9NWQ5 127
xref: PTHR23050:SF427
organism: Canis lupus familiaris

uniprot F1P1X4 396
type: UnificationXref
id: F1P1X4
db: uniprot

ncbitaxon 13616 25
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot P0DP29 135
type: UnificationXref
id: P0DP29
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Lyn-RIGHT__Lyn-_Pi-_r4
controller: CD45

Y Ig beta s47 sa9 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig beta s47 sa9 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=4.865038308779955

Y PLC gamma2 s319 sa27 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y PLC gamma2 s319 sa27 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.010637896575541442

Y BLNK s63 sa21 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s63 sa21 rs4 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.528080903700913
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot P01112 159
type: UnificationXref
id: P01112
db: uniprot

ncbitaxon 7165 149
type: UnificationXref
id: 7165
db: ncbitaxon

ncbitaxon 9598 11
type: UnificationXref
id: 9598
db: ncbitaxon

CD19
type: Protein
entity reference: CD19
feature: Y CD19 s257 a290 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y Ig alpha s41 sa5 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig alpha s41 sa5 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=5.590543463970282

Y Lyn s301 a14 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s301 a14 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.022723360841641067

Blk
type: Protein
entity reference: Blk
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa17 528
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAP2K1 protein
type: ProteinReference
xref: uniprot Q0VD16 236
xref: PTHR48013:SF5
organism: Bos taurus

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot J9P5W6 229
xref: PTHR48013:SF5
organism: Canis lupus familiaris

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F6QUW1 175
xref: PTHR23113:SF168
organism: Monodelphis domestica

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 2

uniprot F1MX21 395
type: UnificationXref
id: F1MX21
db: uniprot

mIgM
type: Complex
component stoichiometry: mIgM s52 sa14 STOICHIOMETRY ID COMPLEX
component: mIgM
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s52 sa14 522
cellular location: cytosol

uniprot F7E823 55
type: UnificationXref
id: F7E823
db: uniprot

mIgM
type: Complex
component stoichiometry: mIgM s43 sa7 STOICHIOMETRY ID COMPLEX
component: mIgM
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s43 sa7 508
cellular location: cytosol

TRUNCATION
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__ERK-_ATP-RIGHT__ADP-_ERK-_r48
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 592
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 593
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 591
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 594
left: ERK
left: ATP
interaction type: STATE_TRANSITION
right: ERK
right: ADP

ncbitaxon 5664 145
type: UnificationXref
id: 5664
db: ncbitaxon

Y Lyn s301 a14 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s301 a14 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MAP2K2 isoform 1
type: ProteinReference
xref: uniprot K7BYT0 230
xref: PTHR48013:SF8
organism: Pan troglodytes

GRB2-related adapter protein
type: ProteinReference
xref: uniprot Q9CX99 76
organism: Mus musculus

BCR-responsive genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

uniprot P48452 290
type: UnificationXref
id: P48452
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7FDA0 331
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot P31938 231
xref: PTHR48013:SF5
organism: Mus musculus

Ras s12 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F6VQP7 398
organism: Monodelphis domestica

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot P70227 407
organism: Mus musculus

Lyn
type: Protein
entity reference: Lyn
feature: Y Lyn s14 a13 rs2
feature: Y Lyn s14 a13 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6Y4G8 439
type: UnificationXref
id: F6Y4G8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 52
organism: Bos taurus

uniprot H2QLB4 60
type: UnificationXref
id: H2QLB4
db: uniprot

Y Ig alpha s41 sa5 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig alpha s41 sa5 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.688003571211971
comment: MODIFICATION_RESIDUE_NAME=Y

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF427
xref: uniprot F7CLC0 124
organism: Monodelphis domestica

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot K7CZM1 181
organism: Pan troglodytes

Ca++
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 92

Y Btk s300 a4 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Btk s300 a4 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Lyn
type: ProteinReference
xref: P00374
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Lyn Synonym: Synonym not specified Accession: P00374
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Lyn
member entity reference: Tyrosine-protein kinase Lyn
member entity reference: Tyrosine-protein kinase

PARTICIPANT STOICHIOMETRY r48 594
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 593
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q14573 409
type: UnificationXref
id: Q14573
db: uniprot

PARTICIPANT STOICHIOMETRY r48 592
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r48 591
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

SOS
type: Protein
entity reference: SOS
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2R0G7 445
type: UnificationXref
id: H2R0G7
db: uniprot

Complex (Calmodulin/Ca++/ Ca++)
type: Complex
component stoichiometry: Ca PLUS PLUS s7 sa34 STOICHIOMETRY ID COMPLEX
component stoichiometry: Calmodulin s6 sa33 STOICHIOMETRY ID COMPLEX
component: Ca++
component: Calmodulin
feature: COMPLEX BINDING FEATURE s125 a215 465
feature: COMPLEX BINDING FEATURE s125 a215 463
cellular location: cytosol

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7E823 55
organism: Monodelphis domestica

TRANSPORT_LEFT__NF_AT-RIGHT__NF_AT-_r72
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 634
participant stoichiometry: PARTICIPANT STOICHIOMETRY r72 633
left: NF-AT
interaction type: TRANSPORT
right: NF-AT

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A818 400
xref: PTHR13715:SF53
organism: Macaca mulatta

uniprot Q9YGC1 370
type: UnificationXref
id: Q9YGC1
db: uniprot

Proto-oncogene vav
type: ProteinReference
xref: PTHR45818:SF2
xref: uniprot P15498 28
organism: Homo sapiens

uniprot O08911 250
type: UnificationXref
id: O08911
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 19

GTPase cRac1A
type: ProteinReference
xref: uniprot Q6LC82 275
xref: PTHR24072:SF105
organism: Gallus gallus

uniprot F6T2A6 122
type: UnificationXref
id: F6T2A6
db: uniprot

Y Syk s46 a70 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Syk s46 a70 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.6585056029845953

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF92
xref: uniprot F6YES1 418
organism: Monodelphis domestica

mIgM s43 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mIgM
stoichiometric coefficient: 2.0

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F1MAI3 171
organism: Rattus norvegicus

jun s145 a259 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Y Lyn s61 sa19 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s61 sa19 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.022723360841641067

uniprot A0A0D1DU81 98
type: UnificationXref
id: A0A0D1DU81
db: uniprot

uniprot Q08209 297
type: UnificationXref
id: Q08209
db: uniprot

Y Syk s46 a70 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Syk s46 a70 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.6188115798754845
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Complex (Rac/GTP)
type: Complex
component stoichiometry: Rac s25 sa54 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s26 sa55 STOICHIOMETRY ID COMPLEX
component: Rac
component: GTP
feature: ACTIVE 5
feature: COMPLEX BINDING FEATURE s156 a277 461
feature: COMPLEX BINDING FEATURE s156 a277 459
cellular location: cytosol

uniprot F1P750 41
type: UnificationXref
id: F1P750
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EH19 56
xref: PTHR24055:SF203
organism: Xenopus tropicalis

uniprot J9NXY2 128
type: UnificationXref
id: J9NXY2
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P68404 86
organism: Mus musculus

uniprot F6YES1 418
type: UnificationXref
id: F6YES1
db: uniprot

PARTICIPANT STOICHIOMETRY r84 685
type: Stoichiometry
physical entity: MEKK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 662
type: Stoichiometry
physical entity: Jnk
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r84 686
type: Stoichiometry
physical entity: MEKK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 661
type: Stoichiometry
physical entity: Jnk
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Complex__Ras_GTP_-_Raf-RIGHT__Complex__Ras_GTP__Raf_-_r43
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 619
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 618
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 620
left: Complex (Ras/GTP)
left: Raf
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Ras/GTP/ Raf)

uniprot F7G3I5 332
type: UnificationXref
id: F7G3I5
db: uniprot

uniprot H2QNG6 336
type: UnificationXref
id: H2QNG6
db: uniprot

uniprot Q04970 160
type: UnificationXref
id: Q04970
db: uniprot

ncbitaxon 39947 143
type: UnificationXref
id: 39947
db: ncbitaxon

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P70618 254
xref: PTHR24055:SF110
organism: Rattus norvegicus

uniprot P02599 131
type: UnificationXref
id: P02599
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot H2QAS6 80
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot Q9JHG7 346
xref: PTHR10048:SF34
organism: Mus musculus

uniprot Q91Y86 453
type: UnificationXref
id: Q91Y86
db: uniprot

PTHR22969:SF13
type: RelationshipXref
id: PTHR22969:SF13
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__PI3K-_CD19-_Lyn-RIGHT__Complex__CD19_Lyn__PI3K_-_r82
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 698
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 697
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 699
participant stoichiometry: PARTICIPANT STOICHIOMETRY r82 696
left: CD19
left: Lyn
left: PI3K
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CD19/Lyn/ PI3K)

VAV1 isoform 2
type: ProteinReference
xref: PTHR45818:SF2
xref: uniprot H2QF58 26
organism: Pan troglodytes

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: PTHR22969:SF7
xref: uniprot O88351 385
organism: Mus musculus

Tyrosine-protein kinase FRK
type: ProteinReference
xref: uniprot Q922K9 314
organism: Mus musculus

uniprot A0A2I3TLP8 13
type: UnificationXref
id: A0A2I3TLP8
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05771 83
organism: Homo sapiens

uniprot F7EH19 56
type: UnificationXref
id: F7EH19
db: uniprot

Calcineurin
type: Protein
entity reference: Calcineurin
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q7ZSZ9 277
type: UnificationXref
id: Q7ZSZ9
db: uniprot

fos
type: Protein
entity reference: fos
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa48 504
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

NF AT s123 a206 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot O14920 383
type: UnificationXref
id: O14920
db: uniprot

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

uniprot P27361 63
type: UnificationXref
id: P27361
db: uniprot

uniprot E9H5Z2 119
type: UnificationXref
id: E9H5Z2
db: uniprot

Ig beta s39 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ig-beta
stoichiometric coefficient: 1.0

uniprot Q07889 183
type: UnificationXref
id: Q07889
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 149

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot A0A2I3RJ26 279
organism: Pan troglodytes

I kappa B
type: Protein
entity reference: I kappa B
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa59 542
feature: I kappa B s32 sa59 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__mIgM_Ig_alpha__Ig_beta_Blk__Btk_Lyn__Syk_-_ATP-RIGHT__ADP-_Complex__mIgM_Ig_alpha__Ig_beta_Blk__Btk_Lyn__Syk_-_r13
controller: Lyn

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F3S0 330
xref: PTHR10048:SF33
organism: Macaca mulatta

Y CD19 s69 sa67 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y CD19 s69 sa67 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot P29350 167
type: UnificationXref
id: P29350
db: uniprot

uniprot O15264 251
type: UnificationXref
id: O15264
db: uniprot

uniprot P42337 342
type: UnificationXref
id: P42337
db: uniprot

DAG
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa51 492
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot A0A1D5QKD3 224
organism: Macaca mulatta

PTHR45818:SF2
type: RelationshipXref
id: PTHR45818:SF2
db: PANTHER Family
relationship type: By Homology

PTHR45818:SF1
type: RelationshipXref
id: PTHR45818:SF1
db: PANTHER Family
relationship type: By Homology

uniprot D3ZFJ0 319
type: UnificationXref
id: D3ZFJ0
db: uniprot

PARTICIPANT STOICHIOMETRY r77 611
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

PTHR45818:SF4
type: RelationshipXref
id: PTHR45818:SF4
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r77 610
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: uniprot P48736 344
xref: PTHR10048:SF34
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot H2PXY8 335
organism: Pan troglodytes

Blk s48 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Blk
stoichiometric coefficient: 1.0

uniprot Q5TM18 354
type: UnificationXref
id: Q5TM18
db: uniprot

uniprot P16298 288
type: UnificationXref
id: P16298
db: uniprot

uniprot Q9Z329 412
type: UnificationXref
id: Q9Z329
db: uniprot

ncbitaxon 6239 130
type: UnificationXref
id: 6239
db: ncbitaxon

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 184

CD45
type: Protein
entity reference: CD45
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PANTHER Pathway P00010 1
type: UnificationXref
id: P00010
db: PANTHER Pathway

Y ERK s131 a243 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ERK s131 a243 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=-0.0

Transcription factor AP-1
type: ProteinReference
xref: uniprot P05412 427
xref: PTHR11462:SF8
organism: Homo sapiens

uniprot H2QDN8 164
type: UnificationXref
id: H2QDN8
db: uniprot

Ca++
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa34 466
cellular location: cytosol
comment: SPECIES_TYPE=ION

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot H9FYU7 180
organism: Macaca mulatta

uniprot F7F486 363
type: UnificationXref
id: F7F486
db: uniprot

uniprot Q01986 234
type: UnificationXref
id: Q01986
db: uniprot

Blk
type: ProteinReference
xref: P00390
standard name: Bcl-2 interacting killer
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Blk
comment: ENTITY_REFERENCE_NOTES=Long Name: Blk Synonym: p55blk Accession: P00390
member entity reference: Tyrosine-protein kinase FRK
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase Blk

PARTICIPANT STOICHIOMETRY r68 646
type: Stoichiometry
physical entity: IKK
stoichiometric coefficient: 1.0

B-cell antigen receptor complex-associated protein beta chain
type: ProteinReference
xref: uniprot P15530 165
xref: PTHR14334:SF2
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r68 647
type: Stoichiometry
physical entity: IKK
stoichiometric coefficient: 1.0

jun s19 sa49 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1PMN2 437
xref: PTHR24055:SF162
organism: Canis lupus familiaris

uniprot A0A3Q2UD13 392
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

Guanine nucleotide exchange factor VAV2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot P52735 32
organism: Homo sapiens

uniprot P09215 84
type: UnificationXref
id: P09215
db: uniprot

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot F1M9D0 39
xref: PTHR24361:SF342
organism: Rattus norvegicus

Complex (CD19/Lyn/ PI3K)
type: Complex
component stoichiometry: PI3K s71 sa69 STOICHIOMETRY ID COMPLEX
component stoichiometry: Lyn s70 sa68 STOICHIOMETRY ID COMPLEX
component stoichiometry: CD19 s69 sa67 STOICHIOMETRY ID COMPLEX
component: CD19
component: PI3K
component: Lyn
feature: COMPLEX BINDING FEATURE s299 a330 497
feature: COMPLEX BINDING FEATURE s299 a330 499
feature: COMPLEX BINDING FEATURE s299 a330 501
cellular location: cytosol

uniprot Q14643 410
type: UnificationXref
id: Q14643
db: uniprot

CD19 s69 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD19
stoichiometric coefficient: 1.0

Predicted protein
type: ProteinReference
xref: uniprot A9S9L5 105
organism: Physcomitrella patens

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7FHD1 59
organism: Monodelphis domestica

Y Lyn s50 sa12 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s50 sa12 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.022723360841641067

Y Btk s66 a109 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Btk s66 a109 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__Jnk-RIGHT__Jnk-_r59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 661
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 662
left: Jnk
interaction type: STATE_TRANSITION
right: Jnk

uniprot P47811 252
type: UnificationXref
id: P47811
db: uniprot

NFKB inhibitor like 1
type: ProteinReference
xref: PTHR15263:SF1
xref: uniprot Q5WR08 355
organism: Canis lupus familiaris

Calmodulin s6 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Calmodulin
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F486 363
xref: PTHR16674:SF2
organism: Macaca mulatta

uniprot A0A1D5QJ66 36
type: UnificationXref
id: A0A1D5QJ66
db: uniprot

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Btk
type: Protein
entity reference: Btk
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s320 sa28 562
feature: Y Btk s320 sa28 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6X6I5 91
type: UnificationXref
id: F6X6I5
db: uniprot

DISSOCIATION
type: InteractionVocabulary

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F1N261 90
xref: PTHR24418:SF42
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RKA7 244
xref: PTHR24055:SF107
organism: Canis lupus familiaris

Ras s16 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot F6XSJ9 265
type: UnificationXref
id: F6XSJ9
db: uniprot

Y Lyn s50 sa12 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s50 sa12 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9QUN3 369
type: UnificationXref
id: Q9QUN3
db: uniprot

uniprot P62157 141
type: UnificationXref
id: P62157
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Calcineurin-RIGHT__Calcineurin-_r37
controller: Complex (Calmodulin/Ca++/ Ca++)

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot F6XSJ9 265
organism: Macaca mulatta

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 217
xref: PTHR44329:SF22
xref: uniprot Q99N57 216
organism: Mus musculus

uniprot Q3T0N5 257
type: UnificationXref
id: Q3T0N5
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 29

STATE_TRANSITION_LEFT__NF_AT-RIGHT__Pi-_NF_AT-_r35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 650
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 648
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 649
left: NF-AT
interaction type: STATE_TRANSITION
right: Pi
right: NF-AT

uniprot P11345 212
type: UnificationXref
id: P11345
db: uniprot

uniprot F1Q118 174
type: UnificationXref
id: F1Q118
db: uniprot

uniprot Q9Z1E3 361
type: UnificationXref
id: Q9Z1E3
db: uniprot

uniprot A0A2J8IJS0 362
type: UnificationXref
id: A0A2J8IJS0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6Y4G8 439
xref: PTHR24055:SF222
organism: Canis lupus familiaris

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot Q60680 386
organism: Mus musculus

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q1HG70 237
organism: Canis lupus familiaris

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF92
xref: uniprot H2QYW8 421
organism: Pan troglodytes

PI3K s71 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

uniprot Q99759 49
type: UnificationXref
id: Q99759
db: uniprot

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

uniprot F7GN93 443
type: UnificationXref
id: F7GN93
db: uniprot

uniprot P25911 96
type: UnificationXref
id: P25911
db: uniprot

uniprot P63086 66
type: UnificationXref
id: P63086
db: uniprot

uniprot C3ZEV9 112
type: UnificationXref
id: C3ZEV9
db: uniprot

Y Ig beta s58 sa16 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig beta s58 sa16 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.7638955247770007
comment: MODIFICATION_RESIDUE_NAME=Y

Y ERK s133 a245 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ERK s133 a245 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=-0.0

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

uniprot H9FU32 206
type: UnificationXref
id: H9FU32
db: uniprot

Ca++
type: SmallMolecule
comment: SPECIES_TYPE=ION

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6V332 246
xref: PTHR24055:SF110
organism: Macaca mulatta

uniprot F7EI48 58
type: UnificationXref
id: F7EI48
db: uniprot

uniprot P70618 254
type: UnificationXref
id: P70618
db: uniprot

TRANSCRIPTION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r1 615
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 644
type: Stoichiometry
physical entity: Calmodulin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 645
type: Stoichiometry
physical entity: Complex (Calmodulin/Ca++/ Ca++)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 612
type: Stoichiometry
physical entity: CD22
stoichiometric coefficient: 1.0

uniprot H2R8U9 179
type: UnificationXref
id: H2R8U9
db: uniprot

PARTICIPANT STOICHIOMETRY r1 613
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot F6USY2 42
type: UnificationXref
id: F6USY2
db: uniprot

PARTICIPANT STOICHIOMETRY r36 643
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 614
type: Stoichiometry
physical entity: CD22
stoichiometric coefficient: 1.0

uniprot H2Q2B8 366
type: UnificationXref
id: H2Q2B8
db: uniprot

uniprot Q5ZIF0 238
type: UnificationXref
id: Q5ZIF0
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

ncbitaxon 44689 132
type: UnificationXref
id: 44689
db: ncbitaxon

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: B cell activation; Differentiation into plasma cell
controller: BCR-responsive mRNA

B cell linker
type: ProteinReference
xref: PTHR14098:SF3
xref: uniprot H2Q2B8 366
organism: Pan troglodytes

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot F1QNG4 154
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF414
xref: uniprot W4XNQ0 150
organism: Strongylocentrotus purpuratus

uniprot G3V926 381
type: UnificationXref
id: G3V926
db: uniprot

Complex (mIgM/Ig-alpha/ Ig-beta)
type: Complex
component stoichiometry: Ig beta s39 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ig alpha s38 sa2 STOICHIOMETRY ID COMPLEX
component: Ig-alpha
component: mIgM
component: Ig-beta
feature: COMPLEX BINDING FEATURE s23 a24 477
feature: COMPLEX BINDING FEATURE s23 a24 481
feature: COMPLEX BINDING FEATURE s23 a24 479
cellular location: cytosol

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: PTHR22969:SF13
xref: uniprot A0A2I3T4Q0 376
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r51 695
type: Stoichiometry
physical entity: jun
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 694
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 693
type: Stoichiometry
physical entity: jun
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r51 692
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 168

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot A0A3S5ZPX3 225
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Rac_GDP_-_GTP-RIGHT__Complex__Rac_GTP_-_GDP-_r57
controller: Complex (BLNK/vav)

Y BLNK s63 sa21 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s63 sa21 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7583620820412538
comment: MODIFICATION_RESIDUE_NAME=Y

Protein kinase C delta type
type: ProteinReference
xref: uniprot P09215 84
xref: PTHR24356:SF365
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F1MYM3 323
organism: Bos taurus

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF92
xref: uniprot Q3ZC95 424
organism: Bos taurus

PTHR23050:SF427
type: RelationshipXref
id: PTHR23050:SF427
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__CD22-_ATP-RIGHT__CD22-_ADP-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 612
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 613
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 614
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 615
left: CD22
left: ATP
interaction type: STATE_TRANSITION
right: CD22
right: ADP

CD19
type: ProteinReference
xref: P00393
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.CD19
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: CD19 Synonym: Synonym not specified Accession: P00393
member entity reference: Uncharacterized protein
member entity reference: CD19 isoform 1
member entity reference: B-lymphocyte antigen CD19

uniprot H2Q0U9 372
type: UnificationXref
id: H2Q0U9
db: uniprot

ncbitaxon 7719 123
type: UnificationXref
id: 7719
db: ncbitaxon

PTHR23050:SF424
type: RelationshipXref
id: PTHR23050:SF424
db: PANTHER Family
relationship type: By Homology

uniprot Q4KM52 367
type: UnificationXref
id: Q4KM52
db: uniprot

uniprot K7BYT0 230
type: UnificationXref
id: K7BYT0
db: uniprot

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: uniprot F1PET4 21
xref: PTHR45818:SF1
organism: Canis lupus familiaris

uniprot P35991 422
type: UnificationXref
id: P35991
db: uniprot

B-cell receptor CD22
type: ProteinReference
xref: uniprot P35329 299
xref: PTHR46958:SF1
organism: Mus musculus

Y BLNK s63 sa21 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s63 sa21 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.426319326209974
comment: MODIFICATION_RESIDUE_NAME=Y

PTHR23050:SF438
type: RelationshipXref
id: PTHR23050:SF438
db: PANTHER Family
relationship type: By Homology

uniprot O77628 191
type: UnificationXref
id: O77628
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YLW2 43
xref: PTHR24361:SF342
organism: Macaca mulatta

Protein kinase C delta type
type: ProteinReference
xref: uniprot H9EU39 81
xref: PTHR24356:SF365
organism: Macaca mulatta

GTP s26 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Y Btk s320 sa28 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Btk s320 sa28 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q3T0N5 257
xref: PTHR24055:SF107
organism: Bos taurus

uniprot A4FV00 435
type: UnificationXref
id: A4FV00
db: uniprot

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

uniprot P0DP28 134
type: UnificationXref
id: P0DP28
db: uniprot

Rac s25 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

uniprot P25963 352
type: UnificationXref
id: P25963
db: uniprot

PLC gamma2
type: Protein
entity reference: PLC gamma2
feature: ACTIVE 5
feature: Y PLC gamma2 s319 sa27 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s319 sa27 560
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Lyn
type: Protein
entity reference: Lyn
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s61 sa19 532
feature: Y Lyn s61 sa19 rs2
feature: Y Lyn s61 sa19 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Btk s49 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Btk
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CD22-_ATP-RIGHT__CD22-_ADP-_r1
controller: Lyn

uniprot F6TXC2 245
type: UnificationXref
id: F6TXC2
db: uniprot

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q28EW2 161
organism: Xenopus tropicalis

Y PLC gamma2 s65 sa23 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y PLC gamma2 s65 sa23 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.010637896575541442

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F1PSC8 219
xref: PTHR24418:SF231
organism: Canis lupus familiaris

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0R4IKK9 430
xref: PTHR24055:SF162
organism: Danio rerio

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot Q8CIH5 306
organism: Mus musculus

uniprot P04157 373
type: UnificationXref
id: P04157
db: uniprot

Blk
type: Protein
entity reference: Blk
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa10 514
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P42338 343
type: UnificationXref
id: P42338
db: uniprot

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

C-fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot A5A6H0 187
organism: Pan troglodytes

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

PTHR23050:SF414
type: RelationshipXref
id: PTHR23050:SF414
db: PANTHER Family
relationship type: By Homology

C-fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot A5A6H2 188
organism: Macaca mulatta

uniprot P16885 305
type: UnificationXref
id: P16885
db: uniprot

uniprot Q95KV1 388
type: UnificationXref
id: Q95KV1
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 145

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot H2QNG6 336
organism: Pan troglodytes

Guanine nucleotide exchange factor VAV3
type: ProteinReference
xref: uniprot Q9UKW4 35
xref: PTHR45818:SF1
organism: Homo sapiens

uniprot D3ZYG0 14
type: UnificationXref
id: D3ZYG0
db: uniprot

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF424
xref: uniprot F7CY56 125
organism: Monodelphis domestica

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 8

Raf s34 sa61 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7GN93 443
xref: PTHR24055:SF162
organism: Macaca mulatta

uniprot P29351 169
type: UnificationXref
id: P29351
db: uniprot

uniprot P0DP23 133
type: UnificationXref
id: P0DP23
db: uniprot

P00402
type: UnificationXref
id: P00402
db: PANTHER Pathway Component

P00401
type: UnificationXref
id: P00401
db: PANTHER Pathway Component

Tyrosine-protein kinase Lyn
type: ProteinReference
xref: PTHR24418:SF42
xref: uniprot Q07014 97
organism: Rattus norvegicus

P00400
type: UnificationXref
id: P00400
db: PANTHER Pathway Component

Ig-alpha
type: Protein
entity reference: Ig-alpha
feature: ACTIVE 5
feature: Y Ig alpha s38 sa2 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa2 480
feature: Y Ig alpha s38 sa2 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 10228 111
type: UnificationXref
id: 10228
db: ncbitaxon

Y Ig beta s58 sa16 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig beta s58 sa16 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=4.865038308779955

uniprot P62994 73
type: UnificationXref
id: P62994
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 208
xref: uniprot P04049 207
xref: PTHR44329:SF22
organism: Homo sapiens

uniprot F6ZKB3 440
type: UnificationXref
id: F6ZKB3
db: uniprot

Y BLNK s8 a86 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s8 a86 rs3 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.95137622615996

B cell activation
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Complex__BLNK_Btk__PLC_gamma2_Grb2__SOS_-_ATP-RIGHT__ADP-_Complex__BLNK_PLC_gamma2__Btk_Grb2__SOS_-_r24
pathway component: HETERODIMER_ASSOCIATION_LEFT__BLNK-_vav-RIGHT__Complex__BLNK_vav_-_r58
pathway component: DISSOCIATION_LEFT__Complex__NF_kappa_B_I_kappa_B_-RIGHT__NF_kappa_B-_I_kappa_B-_r67
pathway component: STATE_TRANSITION_LEFT__Complex__mIgM_Ig_alpha__Ig_beta_Blk__Btk_Lyn__Syk_-_ATP-RIGHT__ADP-_Complex__mIgM_Ig_alpha__Ig_beta_Blk__Btk_Lyn__Syk_-_r13
pathway component: STATE_TRANSITION_LEFT__GTP-_Complex__Ras_GDP__-RIGHT__GDP-_Complex__Ras_GTP_-_r42
pathway component: HETERODIMER_ASSOCIATION_LEFT__DAG-_PKC-RIGHT__Complex__PKC_DAG_-_r52
pathway component: HETERODIMER_ASSOCIATION_LEFT__jun-_fos-RIGHT__Complex__fos_jun_-_r50
pathway component: TRANSPORT_LEFT__NF_kappa_B-RIGHT__NF_kappa_B-_r73
pathway component: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r80
pathway component: STATE_TRANSITION_LEFT__Lyn-RIGHT__Lyn-_Pi-_r4
pathway component: STATE_TRANSITION_LEFT__ERK-_ATP-RIGHT__ADP-_ERK-_r48
pathway component: HETERODIMER_ASSOCIATION_LEFT__Blk-_Complex__mIgM_Ig_alpha__Ig_beta_-_Syk-_Lyn-_Btk-RIGHT__Complex__mIgM_Ig_alpha__Ig_beta_Blk__Btk_Lyn__Syk_-_r8
pathway component: TRANSPORT_LEFT__p38-RIGHT__p38-_r77
pathway component: HETERODIMER_ASSOCIATION_LEFT__Ca_PLUS__PLUS_-_Calmodulin-RIGHT__Complex__Calmodulin_Ca_PLUS__PLUS___Ca_PLUS__PLUS__-_r36
pathway component: STATE_TRANSITION_LEFT__Calcineurin-RIGHT__Calcineurin-_r37
pathway component: STATE_TRANSITION_LEFT__Jnk-RIGHT__Jnk-_r59
pathway component: STATE_TRANSITION_LEFT__ATP-_Btk-RIGHT__ADP-_Btk-_r22
pathway component: TRANSPORT_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r86
pathway component: STATE_TRANSITION_LEFT__CD19-RIGHT__CD19-_r64
pathway component: STATE_TRANSITION_LEFT__ATP-_jun-RIGHT__ADP-_jun-_r51
pathway component: HETERODIMER_ASSOCIATION_LEFT__PI3K-_CD19-_Lyn-RIGHT__Complex__CD19_Lyn__PI3K_-_r82
pathway component: STATE_TRANSITION_LEFT__CRAC-RIGHT__CRAC-_r30
pathway component: TRANSPORT_LEFT__ERK-RIGHT__ERK-_r76
pathway component: TRANSPORT_LEFT__Jnk-RIGHT__Jnk-_r78
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__MEKK-RIGHT__MEKK-_r84
pathway component: TRANSPORT_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r83
pathway component: STATE_TRANSITION_LEFT__Complex__Rac_GDP_-_GTP-RIGHT__Complex__Rac_GTP_-_GDP-_r57
pathway component: TRANSCRIPTION_LEFT__BCR_responsive_genes-RIGHT__BCR_responsive_mRNA-_re50
pathway component: STATE_TRANSITION_LEFT__CD22-_ATP-RIGHT__CD22-_ADP-_r1
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__MEKK-RIGHT__p38-_r85
pathway component: STATE_TRANSITION_LEFT__CD45-RIGHT__CD45-_r79
pathway component: DISSOCIATION_LEFT__Complex__Ras_Raf__MEK_GTP_-RIGHT__Complex__Ras_GTP__Raf_-_MEK-_r75
pathway component: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r68
pathway component: STATE_TRANSITION_LEFT__BLNK-_ATP-RIGHT__ADP-_BLNK-_r14
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Ras_GTP_-_Raf-RIGHT__Complex__Ras_GTP__Raf_-_r43
pathway component: STATE_TRANSITION_LEFT__NF_AT-RIGHT__Pi-_NF_AT-_r35
pathway component: STATE_TRANSITION_LEFT__Lyn-_ATP-RIGHT__ADP-_Lyn-_r5
pathway component: TRANSPORT_LEFT__NF_AT-RIGHT__NF_AT-_r72
pathway component: HETERODIMER_ASSOCIATION_LEFT__Grb2-_BLNK-_PLC_gamma2-_SOS-_Btk-RIGHT__Complex__BLNK_Btk__PLC_gamma2_Grb2__SOS_-_r71
pathway component: STATE_TRANSITION_LEFT__Complex__mIgM_Ig_alpha__Ig_beta_-_ATP-RIGHT__ADP-_Complex__mIgM_Ig_alpha__Ig_beta_-_r7
pathway component: HETERODIMER_ASSOCIATION_LEFT__CD22-_SHP_1-RIGHT__Complex__SHP_1_CD22_-_r32
pathway component: TRUNCATION_LEFT__PIP2-RIGHT__DAG-_IP3-_r23
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Ras_GTP__Raf_-_MEK-RIGHT__Complex__Ras_Raf__MEK_GTP_-_r74
xref: PANTHER Pathway P00010 1
comment: MODEL_NOTES=Panther Pathway: P00010 B cell activation entails the process by which a pre-B cell matures into a plasma cell. The signaling pathways that regulate this conversion are complex, but center around a complex of proteins referred to as the B cell receptor, or BCR. Ligation of the BCR by a cognate antigen initiates a number of downstream signaling events that lead, eventually, to an expansion in the number of B cells of the appropriate antigen specificity, and to their development of the ability to secrete antibody. Medline=11913948 Medline=12040177 Medline=12119152 PMID: 11913948 PMID: 12040177 PMID: 12119152

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P79996 451
organism: Gallus gallus

uniprot A0A1D5R9U8 195
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63001 269
organism: Mus musculus

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63000 268
organism: Homo sapiens

uniprot Q14571 408
type: UnificationXref
id: Q14571
db: uniprot

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q9Y2U5 50
xref: PTHR24361:SF342
organism: Homo sapiens

Y Lyn s14 a13 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s14 a13 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Y BLNK s8 a86 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s8 a86 rs4 Y
comment: MODIFICATION_RESIDUE_ANGLE=5.528080903700913
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Y Lyn s14 a13 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s14 a13 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.022723360841641067

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot F7C798 248
organism: Macaca mulatta

uniprot F1PXS7 54
type: UnificationXref
id: F1PXS7
db: uniprot

uniprot Q60992 33
type: UnificationXref
id: Q60992
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GY91 266
xref: PTHR24072:SF325
organism: Macaca mulatta

Tyrosine-protein kinase SYK
type: ProteinReference
xref: uniprot Q64725 223
xref: PTHR24418:SF231
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot Q14643 410
organism: Homo sapiens

Y Ig beta s42 sa6 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig beta s42 sa6 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.7638955247770007
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot A0A2J8QY32 318
type: UnificationXref
id: A0A2J8QY32
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot O77628 191
organism: Bos taurus

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot O77627 426
organism: Bos taurus

STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r80
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 576
participant stoichiometry: PARTICIPANT STOICHIOMETRY r80 575
left: IP3R
interaction type: STATE_TRANSITION
right: IP3R

uniprot E1BE66 321
type: UnificationXref
id: E1BE66
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Jnk-RIGHT__Jnk-_r59
controller: MEKK

uniprot Q04982 215
type: UnificationXref
id: Q04982
db: uniprot

Y Ig beta s42 sa6 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig beta s42 sa6 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=4.865038308779955

uniprot P45984 447
type: UnificationXref
id: P45984
db: uniprot

NF-AT
type: Protein
feature: ACTIVE 5
feature: NF AT s129 a241 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa63 556
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CD79A isoform 1
type: ProteinReference
xref: PTHR14334:SF1
xref: uniprot H2QGF1 413
organism: Pan troglodytes

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot Q08209 297
organism: Homo sapiens

uniprot Q63844 67
type: UnificationXref
id: Q63844
db: uniprot

PARTICIPANT STOICHIOMETRY r8 577
type: Stoichiometry
physical entity: Blk
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 578
type: Stoichiometry
physical entity: Complex (mIgM/Ig-alpha/ Ig-beta)
stoichiometric coefficient: 1.0

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot Q95KV0 387
xref: PTHR22969:SF7
organism: Bos taurus

Inhibitor of nuclear factor kappa-B kinase subunit alpha
type: ProteinReference
xref: uniprot Q95KV1 388
xref: PTHR22969:SF13
organism: Bos taurus

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F7BV42 93
xref: PTHR24418:SF42
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EJL2 24
xref: PTHR45818:SF1
organism: Monodelphis domestica

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 11

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q15759 255
organism: Homo sapiens

uniprot H2QSU0 402
type: UnificationXref
id: H2QSU0
db: uniprot

STATE_TRANSITION_LEFT__Complex__mIgM_Ig_alpha__Ig_beta_Blk__Btk_Lyn__Syk_-_ATP-RIGHT__ADP-_Complex__mIgM_Ig_alpha__Ig_beta_Blk__Btk_Lyn__Syk_-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 609
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 608
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 607
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 606
left: Complex (mIgM/Ig-alpha/ Ig-beta/Blk/ Btk/Lyn/ Syk)
left: ATP
interaction type: STATE_TRANSITION
right: Complex (mIgM/Ig-alpha/ Ig-beta/Blk/ Btk/Lyn/ Syk)
right: ADP

Y Syk s51 sa13 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Syk s51 sa13 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.6585056029845953

Grb2 s67 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 580
type: Stoichiometry
physical entity: Lyn
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
evidence: Evidence 198
evidence: Evidence 197
evidence: Evidence 199
evidence: Evidence 196
xref: PTHR44329:SF22
xref: uniprot A0A1D5R9U8 195
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r8 581
type: Stoichiometry
physical entity: Btk
stoichiometric coefficient: 1.0

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa25 476
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r8 582
type: Stoichiometry
physical entity: Complex (mIgM/Ig-alpha/ Ig-beta/Blk/ Btk/Lyn/ Syk)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 664
type: Stoichiometry
physical entity: vav
stoichiometric coefficient: 1.0

PLC gamma2 s319 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PLC gamma2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 665
type: Stoichiometry
physical entity: Complex (BLNK/vav)
stoichiometric coefficient: 1.0

uniprot Q922K9 314
type: UnificationXref
id: Q922K9
db: uniprot

PARTICIPANT STOICHIOMETRY r8 579
type: Stoichiometry
physical entity: Syk
stoichiometric coefficient: 1.0

uniprot P11912 415
type: UnificationXref
id: P11912
db: uniprot

uniprot Q64725 223
type: UnificationXref
id: Q64725
db: uniprot

PARTICIPANT STOICHIOMETRY r58 663
type: Stoichiometry
physical entity: BLNK
stoichiometric coefficient: 1.0

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

Y Syk s51 sa13 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Syk s51 sa13 rs1 Y
comment: MODIFICATION_RESIDUE_ANGLE=5.6188115798754845
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot B5DF98 38
type: UnificationXref
id: B5DF98
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot F1P750 41
xref: PTHR24361:SF656
organism: Canis lupus familiaris

Conserved helix-loop-helix ubiquitous kinase
type: ProteinReference
xref: uniprot E2RNA9 378
xref: PTHR22969:SF13
organism: Canis lupus familiaris

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 213
xref: uniprot P11345 212
xref: PTHR44329:SF22
organism: Rattus norvegicus

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

uniprot P08575 374
type: UnificationXref
id: P08575
db: uniprot

uniprot P11881 404
type: UnificationXref
id: P11881
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot O15264 251
organism: Homo sapiens

Blk
type: Protein
entity reference: Blk
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y BLNK s8 a86 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s8 a86 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.426319326209974
comment: MODIFICATION_RESIDUE_NAME=Y

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__mIgM_Ig_alpha__Ig_beta_-_ATP-RIGHT__ADP-_Complex__mIgM_Ig_alpha__Ig_beta_-_r7
controller: Lyn

uniprot A0A0G2K5T3 316
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

jun s19 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: jun
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__BLNK_Btk__PLC_gamma2_Grb2__SOS_-_ATP-RIGHT__ADP-_Complex__BLNK_PLC_gamma2__Btk_Grb2__SOS_-_r24
controller: Complex (BLNK/Btk/ PLC gamma2/Grb2/ SOS)

STATE_TRANSITION_LEFT__Lyn-RIGHT__Lyn-_Pi-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 597
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 599
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 598
left: Lyn
interaction type: STATE_TRANSITION
right: Pi
right: Lyn

uniprot O88351 385
type: UnificationXref
id: O88351
db: uniprot

Tyrosine-protein kinase Lyn
type: ProteinReference
xref: PTHR24418:SF42
xref: uniprot P25911 96
organism: Mus musculus

PTHR23351:SF4
type: RelationshipXref
id: PTHR23351:SF4
db: PANTHER Family
relationship type: By Homology

uniprot A9S9L5 105
type: UnificationXref
id: A9S9L5
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q04970 160
xref: PTHR24070:SF189
organism: Rattus norvegicus

Ca PLUS PLUS s7 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NF_AT-RIGHT__Pi-_NF_AT-_r35
controller: Calcineurin

uniprot F6WV79 438
type: UnificationXref
id: F6WV79
db: uniprot

Y BLNK s8 a86 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s8 a86 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7583620820412538
comment: MODIFICATION_RESIDUE_NAME=Y

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot Q07890 185
organism: Homo sapiens

uniprot P05771 83
type: UnificationXref
id: P05771
db: uniprot

PI3K
type: Protein
entity reference: PI3K
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F7B5L8 441
organism: Ornithorhynchus anatinus

I kappa B s265 a305 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Y BLNK s302 a31 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s302 a31 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.426319326209974
comment: MODIFICATION_RESIDUE_NAME=Y

Complex (Rac/GDP)
type: Complex
component stoichiometry: GDP s24 sa53 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rac s22 sa52 STOICHIOMETRY ID COMPLEX
component: Rac
component: GDP
feature: COMPLEX BINDING FEATURE s155 a276 535
feature: COMPLEX BINDING FEATURE s155 a276 537
cellular location: cytosol

uniprot F6YCI3 177
type: UnificationXref
id: F6YCI3
db: uniprot

ncbitaxon 237631 99
type: UnificationXref
id: 237631
db: ncbitaxon

uniprot A0A3Q1LWJ8 433
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Blk-_Complex__mIgM_Ig_alpha__Ig_beta_-_Syk-_Lyn-_Btk-RIGHT__Complex__mIgM_Ig_alpha__Ig_beta_Blk__Btk_Lyn__Syk_-_r8
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 582
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 580
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 577
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 578
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 581
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 579
left: Btk
left: Lyn
left: Syk
left: Complex (mIgM/Ig-alpha/ Ig-beta)
left: Blk
interaction type: HETERODIMER_ASSOCIATION
right: Complex (mIgM/Ig-alpha/ Ig-beta/Blk/ Btk/Lyn/ Syk)

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 23

uniprot P16277 312
type: UnificationXref
id: P16277
db: uniprot

DAG s21 sa51 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

PTHR16674:SF2
type: RelationshipXref
id: PTHR16674:SF2
db: PANTHER Family
relationship type: By Homology

Btk
type: Protein
entity reference: Btk
feature: Y Btk s60 sa18 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa18 530
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q9TU25 278
xref: PTHR24072:SF169
organism: Bos taurus

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P04627 209
organism: Mus musculus

HETERODIMER_ASSOCIATION_LEFT__Grb2-_BLNK-_PLC_gamma2-_SOS-_Btk-RIGHT__Complex__BLNK_Btk__PLC_gamma2_Grb2__SOS_-_r71
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 640
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 639
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 636
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 638
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 635
participant stoichiometry: PARTICIPANT STOICHIOMETRY r71 637
left: Btk
left: Grb2
left: SOS
left: PLC gamma2
left: BLNK
interaction type: HETERODIMER_ASSOCIATION
right: Complex (BLNK/Btk/ PLC gamma2/Grb2/ SOS)

PARTICIPANT STOICHIOMETRY r82 698
type: Stoichiometry
physical entity: Lyn
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 699
type: Stoichiometry
physical entity: Complex (CD19/Lyn/ PI3K)
stoichiometric coefficient: 1.0

uniprot Q9N272 260
type: UnificationXref
id: Q9N272
db: uniprot

CD22
type: Protein
entity reference: CD22
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa32 458
feature: Y CD22 s5 sa32 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CRAC
type: Protein
feature: ACTIVE 5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1QNG4 154
type: UnificationXref
id: F1QNG4
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 197
xref: PTHR44329:SF22
xref: uniprot P05625 210
organism: Gallus gallus

Y BLNK s302 a31 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s302 a31 rs4 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.528080903700913
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05627 428
organism: Mus musculus

uniprot A0A1D5NVQ5 6
type: UnificationXref
id: A0A1D5NVQ5
db: uniprot

uniprot P42336 341
type: UnificationXref
id: P42336
db: uniprot

PTHR24361:SF342
type: RelationshipXref
id: PTHR24361:SF342
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r86 678
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 1.0

Y BLNK s302 a31 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s302 a31 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.95137622615996

PARTICIPANT STOICHIOMETRY r86 677
type: Stoichiometry
physical entity: Ca++
stoichiometric coefficient: 1.0

uniprot A5A6H2 188
type: UnificationXref
id: A5A6H2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Lyn-_ATP-RIGHT__ADP-_Lyn-_r5
controller: Lyn

uniprot F6W7C8 327
type: UnificationXref
id: F6W7C8
db: uniprot

uniprot F6R543 397
type: UnificationXref
id: F6R543
db: uniprot

Complex (Ras/GTP/ Raf)
type: Complex
component stoichiometry: GTP s73 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: Raf s74 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ras s72 sa40 STOICHIOMETRY ID COMPLEX
component: Raf
component: Ras
component: GTP
feature: COMPLEX BINDING FEATURE s310 a230 547
feature: COMPLEX BINDING FEATURE s310 a230 543
feature: COMPLEX BINDING FEATURE s310 a230 545
cellular location: cytosol

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

uniprot E2REK6 116
type: UnificationXref
id: E2REK6
db: uniprot

B-cell antigen receptor complex-associated protein alpha chain
type: ProteinReference
xref: PTHR14334:SF1
xref: uniprot P40293 416
organism: Bos taurus

uniprot F6XT65 228
type: UnificationXref
id: F6XT65
db: uniprot

Y BLNK s302 a31 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s302 a31 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7583620820412538
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot E2RL20 204
type: UnificationXref
id: E2RL20
db: uniprot

uniprot P29995 406
type: UnificationXref
id: P29995
db: uniprot

uniprot F7A632 78
type: UnificationXref
id: F7A632
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__BCR_responsive_genes-RIGHT__BCR_responsive_mRNA-_re50
control type: ACTIVATION
controller: NF-AT

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O35904 339
organism: Mus musculus

uniprot Q61411 163
type: UnificationXref
id: Q61411
db: uniprot

PARTICIPANT STOICHIOMETRY r42 627
type: Stoichiometry
physical entity: Complex (Ras/GTP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r42 625
type: Stoichiometry
physical entity: Complex (Ras/GDP )
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r42 626
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot A0A3Q1LPF2 37
xref: PTHR24361:SF656
organism: Bos taurus

TRANSCRIPTION_LEFT__BCR_responsive_genes-RIGHT__BCR_responsive_mRNA-_re50
type: TemplateReaction
product: BCR-responsive mRNA
xref: TRANSCRIPTION
participant: BCR-responsive mRNA
participant: BCR-responsive genes
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY r42 624
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__mIgM_Ig_alpha__Ig_beta_Blk__Btk_Lyn__Syk_-_ATP-RIGHT__ADP-_Complex__mIgM_Ig_alpha__Ig_beta_Blk__Btk_Lyn__Syk_-_r13
controller: Syk

Jnk
type: ProteinReference
xref: P00402
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Jnk
comment: ENTITY_REFERENCE_NOTES=Long Name: Jnk Synonym: Jun Kinase Accession: P00402
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase 10

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot A0A2I3RSP9 280
organism: Pan troglodytes

GDP s15 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Puccinia graminis
type: BioSource
xref: ncbitaxon 418459 118

Syk s51 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Syk
stoichiometric coefficient: 1.0

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot D4A3T0 170
xref: PTHR23113:SF168
organism: Rattus norvegicus

PTHR10336:SF25
type: RelationshipXref
id: PTHR10336:SF25
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot A0A2I3RJ26 279
type: UnificationXref
id: A0A2I3RJ26
db: uniprot

uniprot Q06187 423
type: UnificationXref
id: Q06187
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa37 496
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot B3RJX8 110
type: UnificationXref
id: B3RJX8
db: uniprot

BLNK s318 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BLNK
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P1X4 396
xref: PTHR13715:SF53
organism: Gallus gallus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A2I3SHP7 301
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r82 696
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r82 697
type: Stoichiometry
physical entity: CD19
stoichiometric coefficient: 1.0

Jnk
type: Protein
entity reference: Jnk
feature: ACTIVE 5
feature: Jnk s251 a285 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot K7CZM1 181
type: UnificationXref
id: K7CZM1
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot P15153 267
organism: Homo sapiens

uniprot A7RPN8 102
type: UnificationXref
id: A7RPN8
db: uniprot

uniprot Q15759 255
type: UnificationXref
id: Q15759
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 104

uniprot Q6DGB7 273
type: UnificationXref
id: Q6DGB7
db: uniprot

uniprot E2RJ59 283
type: UnificationXref
id: E2RJ59
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 130

B-cell antigen receptor complex-associated protein beta chain
type: ProteinReference
xref: uniprot P40259 166
xref: PTHR14334:SF2
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q8BTI9 345
xref: PTHR10048:SF33
organism: Mus musculus

SHP-1
type: Protein
entity reference: SHP-1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 198
evidence: Evidence 197
evidence: Evidence 199
evidence: Evidence 196
xref: uniprot E2REI6 203
xref: PTHR44329:SF22
organism: Canis lupus familiaris

Map3k3 protein
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot B5DF98 38
organism: Rattus norvegicus

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q07889 183
organism: Homo sapiens

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot O08911 250
organism: Mus musculus

ncbitaxon 81824 109
type: UnificationXref
id: 81824
db: ncbitaxon

uniprot F7GAP5 333
type: UnificationXref
id: F7GAP5
db: uniprot

mIgM
type: Protein
entity reference: mIgM
feature: ACTIVE 5

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot F6SEH5 286
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r57 669
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 667
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot H2PXY8 335
type: UnificationXref
id: H2PXY8
db: uniprot

PARTICIPANT STOICHIOMETRY r57 668
type: Stoichiometry
physical entity: Complex (Rac/GTP)
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot D4A3U7 243
organism: Rattus norvegicus

NF-AT
type: Protein
feature: ACTIVE 5
feature: NF AT s122 a205 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r57 666
type: Stoichiometry
physical entity: Complex (Rac/GDP)
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2R2N2 53
xref: PTHR24055:SF203
organism: Canis lupus familiaris

HETERODIMER_ASSOCIATION_LEFT__Ca_PLUS__PLUS_-_Calmodulin-RIGHT__Complex__Calmodulin_Ca_PLUS__PLUS___Ca_PLUS__PLUS__-_r36
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 644
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 643
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 645
left: Ca++
left: Calmodulin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Calmodulin/Ca++/ Ca++)

uniprot F7BKT0 420
type: UnificationXref
id: F7BKT0
db: uniprot

Complex (SHP-1/CD22)
type: Complex
component stoichiometry: SHP 1 s4 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: CD22 s5 sa32 STOICHIOMETRY ID COMPLEX
component: CD22
component: SHP-1
feature: COMPLEX BINDING FEATURE s118 a201 457
feature: COMPLEX BINDING FEATURE s118 a201 455
cellular location: cytosol

uniprot F6YLW2 43
type: UnificationXref
id: F6YLW2
db: uniprot

uniprot F7BRK5 205
type: UnificationXref
id: F7BRK5
db: uniprot

uniprot E2R6T4 425
type: UnificationXref
id: E2R6T4
db: uniprot

uniprot F7BVQ1 304
type: UnificationXref
id: F7BVQ1
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P32871 340
xref: PTHR10048:SF107
organism: Bos taurus

TRANSPORT_LEFT__ERK-RIGHT__ERK-_r76
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 616
participant stoichiometry: PARTICIPANT STOICHIOMETRY r76 617
left: ERK
interaction type: TRANSPORT
right: ERK

T ERK s131 a243 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T ERK s131 a243 rs1 T
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

NFKB inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot E2RML9 349
organism: Canis lupus familiaris

PTHR46257:SF4
type: RelationshipXref
id: PTHR46257:SF4
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r83
control type: ACTIVATION
controller: CRAC

Calmodulin 1
type: ProteinReference
xref: PTHR23050:SF381
xref: uniprot E2REK6 116
organism: Canis lupus familiaris

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot E1BE66 321
xref: PTHR10048:SF35
organism: Bos taurus

…
type: Stoichiometry
physical entity: mIgM
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24418:SF231
xref: uniprot F7GLV2 220
organism: Macaca mulatta

uniprot F7GLV2 220
type: UnificationXref
id: F7GLV2
db: uniprot

jun
type: Protein
entity reference: jun
feature: jun s143 a258 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Btk
type: Protein
entity reference: Btk
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa11 516
feature: Y Btk s49 sa11 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

Y CD22 s13 a12 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y CD22 s13 a12 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot Q4KM97 313
xref: PTHR24418:SF181
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P11881 404
organism: Mus musculus

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 113

SHP 1 s4 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SHP-1
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YCI3 177
xref: PTHR23113:SF150
organism: Monodelphis domestica

Predicted protein
type: ProteinReference
xref: uniprot A9SHH7 107
organism: Physcomitrella patens

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P12841 194
organism: Rattus norvegicus

uniprot P63328 293
type: UnificationXref
id: P63328
db: uniprot

CD22
type: Protein
entity reference: CD22
feature: ACTIVE 5
feature: Y CD22 s13 a12 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot P45983 446
organism: Homo sapiens

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P45984 447
organism: Homo sapiens

CRAC
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot G5E513 307
organism: Bos taurus

Y Ig alpha s54 sa15 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig alpha s54 sa15 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=5.590543463970282

Btk
type: ProteinReference
xref: P00400
comment: ENTITY_REFERENCE_NOTES=Long Name: Btk Synonym: bruton's tyrosine kinase Accession: P00400
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Btk
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase BTK

PI3K
type: ProteinReference
xref: P00391
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.PI3K
comment: ENTITY_REFERENCE_NOTES=Long Name: PI3K Synonym: Phosphatidyl inositol 3-kinase Accession: P00391
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: PIK3CG isoform 1
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P14056 214
xref: PTHR44329:SF55
organism: Rattus norvegicus

Guanine nucleotide exchange factor VAV2 isoform 1
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot I2CU78 27
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r71 635
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

PKC s20 sa50 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 637
type: Stoichiometry
physical entity: PLC gamma2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 636
type: Stoichiometry
physical entity: BLNK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 639
type: Stoichiometry
physical entity: Btk
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r71 638
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 674
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 123

PARTICIPANT STOICHIOMETRY r71 640
type: Stoichiometry
physical entity: Complex (BLNK/Btk/ PLC gamma2/Grb2/ SOS)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 676
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

Ig-beta
type: Protein
entity reference: Ig-beta
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa3 482
feature: Y Ig beta s39 sa3 rs1
feature: Y Ig beta s39 sa3 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r23 675
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

uniprot A0A452DI16 202
type: UnificationXref
id: A0A452DI16
db: uniprot

GTPase HRas
type: ProteinReference
xref: uniprot Q61411 163
xref: PTHR24070:SF385
organism: Mus musculus

p38
type: Protein
entity reference: p38
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05126 82
organism: Bos taurus

BLNK s27 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BLNK
stoichiometric coefficient: 1.0

TRANSCRIPTION
type: InteractionVocabulary

KNOWN_TRANSITION_OMITTED_LEFT__MEKK-RIGHT__p38-_r85
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 683
participant stoichiometry: PARTICIPANT STOICHIOMETRY r85 684
left: MEKK
interaction type: KNOWN_TRANSITION_OMITTED
right: p38

ADP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Complex (Ras/Raf/ MEK/GTP)
type: Complex
component stoichiometry: Raf s34 sa61 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s36 sa63 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ras s33 sa60 STOICHIOMETRY ID COMPLEX
component stoichiometry: MEK s35 sa62 STOICHIOMETRY ID COMPLEX
component: Raf
component: MEK
component: GTP
component: Ras
feature: COMPLEX BINDING FEATURE s272 a315 551
feature: COMPLEX BINDING FEATURE s272 a315 549
feature: COMPLEX BINDING FEATURE s272 a315 553
feature: COMPLEX BINDING FEATURE s272 a315 555
cellular location: cytosol

IKK s262 a308 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

NF kappa B s31 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NF-kappa B
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2B catalytic subunit
type: ProteinReference
xref: uniprot Q05681 295
xref: PTHR45673:SF1
organism: Neurospora crassa

PARTICIPANT STOICHIOMETRY r72 633
type: Stoichiometry
physical entity: NF-AT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r72 634
type: Stoichiometry
physical entity: NF-AT
stoichiometric coefficient: 1.0

BCR-responsive mRNA
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

uniprot Q05681 295
type: UnificationXref
id: Q05681
db: uniprot

uniprot Q3ZC95 424
type: UnificationXref
id: Q3ZC95
db: uniprot

uniprot F7CLC0 124
type: UnificationXref
id: F7CLC0
db: uniprot

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

uniprot Q6GL60 274
type: UnificationXref
id: Q6GL60
db: uniprot

PTHR13715:SF51
type: RelationshipXref
id: PTHR13715:SF51
db: PANTHER Family
relationship type: By Homology

Y Ig alpha s54 sa15 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig alpha s54 sa15 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.688003571211971
comment: MODIFICATION_RESIDUE_NAME=Y

PTHR13715:SF53
type: RelationshipXref
id: PTHR13715:SF53
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: PTHR44329:SF55
xref: uniprot P10398 211
organism: Homo sapiens

B-cell linker protein
type: ProteinReference
xref: uniprot Q4KM52 367
xref: PTHR14098:SF3
organism: Rattus norvegicus

BLNK
type: Protein
entity reference: BLNK
feature: Y BLNK s302 a31 rs4
feature: Y BLNK s302 a31 rs2
feature: Y BLNK s302 a31 rs1
feature: Y BLNK s302 a31 rs3
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Receptor-type tyrosine-protein phosphatase C
type: ProteinReference
xref: PTHR19134:SF284
xref: uniprot P08575 374
organism: Homo sapiens

uniprot E1C2T7 282
type: UnificationXref
id: E1C2T7
db: uniprot

eco ECO:0000304 168
type: UnificationXref
id: ECO:0000304
db: eco

MEK s35 sa62 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q05655 87
type: UnificationXref
id: Q05655
db: uniprot

Calmodulin-1
type: ProteinReference
xref: PTHR23050:SF383
xref: uniprot P0DP29 135
organism: Rattus norvegicus

Lyn s61 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Lyn
stoichiometric coefficient: 1.0

Calmodulin-3
type: ProteinReference
xref: PTHR23050:SF381
xref: uniprot P0DP28 134
organism: Mus musculus

Calmodulin-1
type: ProteinReference
xref: PTHR23050:SF427
xref: uniprot P0DP23 133
organism: Homo sapiens

PLC gamma2
type: Protein
entity reference: PLC gamma2
feature: Y PLC gamma2 s55 a90 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

AGAP010957-PA (Fragment)
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot Q7QGY7 148
organism: Anopheles gambiae

PTHR19134:SF284
type: RelationshipXref
id: PTHR19134:SF284
db: PANTHER Family
relationship type: By Homology

uniprot Q9WUI1 262
type: UnificationXref
id: Q9WUI1
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: MEK s235 a235 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9544 23
type: UnificationXref
id: 9544
db: ncbitaxon

Y Btk s64 sa22 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Btk s64 sa22 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7DKU1 287
type: UnificationXref
id: F7DKU1
db: uniprot

uniprot F6VQP7 398
type: UnificationXref
id: F6VQP7
db: uniprot

Ras s33 sa60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot H2RA86 61
type: UnificationXref
id: H2RA86
db: uniprot

uniprot H2QF58 26
type: UnificationXref
id: H2QF58
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1N7C3 172
xref: PTHR23113:SF168
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 65
organism: Mus musculus

uniprot A0A0R4IKK9 430
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63086 66
organism: Rattus norvegicus

GTP s17 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot O35904 339
type: UnificationXref
id: O35904
db: uniprot

Complex (NF-kappa B/I kappa B)
type: Complex
component stoichiometry: I kappa B s32 sa59 STOICHIOMETRY ID COMPLEX
component stoichiometry: NF kappa B s31 sa58 STOICHIOMETRY ID COMPLEX
component: I kappa B
component: NF-kappa B
feature: COMPLEX BINDING FEATURE s266 a307 541
feature: COMPLEX BINDING FEATURE s266 a307 539
cellular location: cytosol

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot P53778 253
organism: Homo sapiens

uniprot Q1HG70 237
type: UnificationXref
id: Q1HG70
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P53779 450
xref: PTHR24055:SF162
organism: Homo sapiens

MEKK
type: Protein
entity reference: MEKK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PIP2
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6YAB9 247
type: UnificationXref
id: F6YAB9
db: uniprot

uniprot F7GY91 266
type: UnificationXref
id: F7GY91
db: uniprot

…
type: Stoichiometry
physical entity: mIgM
stoichiometric coefficient: 2.0

Y Ig alpha s38 sa2 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig alpha s38 sa2 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=5.590543463970282

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__jun-_fos-RIGHT__Complex__fos_jun_-_r50
controller: p38

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R1G4 348
xref: PTHR46680:SF1
organism: Macaca mulatta

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: PTHR24361:SF342
xref: uniprot F1MSX4 40
organism: Bos taurus

Rac family small GTPase 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6GL60 274
organism: Xenopus tropicalis

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
evidence: Evidence 198
evidence: Evidence 197
evidence: Evidence 199
evidence: Evidence 196
xref: PTHR44329:SF22
xref: uniprot F7BRK5 205
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q02750 235
xref: PTHR48013:SF5
organism: Homo sapiens

uniprot Q7QGY7 148
type: UnificationXref
id: Q7QGY7
db: uniprot

uniprot F1N7C3 172
type: UnificationXref
id: F1N7C3
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q62245 186
organism: Mus musculus

Y Syk s2 a57 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Syk s2 a57 rs1 Y
comment: MODIFICATION_RESIDUE_ANGLE=5.6188115798754845
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

STATE_TRANSITION_LEFT__CD19-RIGHT__CD19-_r64
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 657
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 658
left: CD19
interaction type: STATE_TRANSITION
right: CD19

uniprot D4A3U7 243
type: UnificationXref
id: D4A3U7
db: uniprot

Grb2 s321 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

uniprot A0A3Q1LPF2 37
type: UnificationXref
id: A0A3Q1LPF2
db: uniprot

Y Ig alpha s38 sa2 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Ig alpha s38 sa2 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.688003571211971
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot Q61083 46
type: UnificationXref
id: Q61083
db: uniprot

uniprot Q9UBC1 360
type: UnificationXref
id: Q9UBC1
db: uniprot

uniprot P45983 446
type: UnificationXref
id: P45983
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LWJ8 433
xref: PTHR24055:SF222
organism: Bos taurus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot E2RJ59 283
organism: Canis lupus familiaris

Inhibitor of nuclear factor kappa-B kinase subunit beta
type: ProteinReference
xref: uniprot Q9QY78 389
xref: PTHR22969:SF7
organism: Rattus norvegicus

Complex (mIgM/Ig-alpha/ Ig-beta/Blk/ Btk/Lyn/ Syk)
type: Complex
component stoichiometry: Ig alpha s45 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Blk s48 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Lyn s50 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ig beta s47 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: Btk s49 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Syk s51 sa13 STOICHIOMETRY ID COMPLEX
component: Syk
component: Lyn
component: Btk
component: mIgM
component: Blk
component: Ig-beta
component: Ig-alpha
feature: COMPLEX BINDING FEATURE s44 a66 515
feature: COMPLEX BINDING FEATURE s44 a66 517
feature: COMPLEX BINDING FEATURE s44 a66 519
feature: COMPLEX BINDING FEATURE s44 a66 513
feature: COMPLEX BINDING FEATURE s44 a66 511
feature: COMPLEX BINDING FEATURE s44 a66 507
feature: COMPLEX BINDING FEATURE s44 a66 509
cellular location: cytosol

p38
type: ProteinReference
xref: P00384
standard name: p38 mitogen activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.p38
comment: ENTITY_REFERENCE_NOTES=Long Name: p38 Synonym: MAP kinase Accession: P00384
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 13

Y Syk s2 a57 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Syk s2 a57 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.6585056029845953

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q05655 87
xref: PTHR24356:SF365
organism: Homo sapiens

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 120

uniprot E1BKE7 393
type: UnificationXref
id: E1BKE7
db: uniprot

MEK s247 a234 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Btk s64 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Btk
stoichiometric coefficient: 1.0

CD22 s5 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CD22
stoichiometric coefficient: 1.0

uniprot E2RKA7 244
type: UnificationXref
id: E2RKA7
db: uniprot

Calmodulin
type: ProteinReference
xref: uniprot P02599 131
organism: Dictyostelium discoideum

GTPase HRas isoform 1
type: ProteinReference
xref: uniprot F7F5K9 155
xref: PTHR24070:SF385
organism: Macaca mulatta

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: PTHR45818:SF1
xref: uniprot F1LWB1 20
organism: Rattus norvegicus

uniprot F6URW3 176
type: UnificationXref
id: F6URW3
db: uniprot

uniprot F6SW23 325
type: UnificationXref
id: F6SW23
db: uniprot

mIgM s37 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mIgM
stoichiometric coefficient: 2.0

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q63746 356
organism: Rattus norvegicus

uniprot F6VXG1 326
type: UnificationXref
id: F6VXG1
db: uniprot

uniprot F1MSX4 40
type: UnificationXref
id: F1MSX4
db: uniprot

uniprot O77627 426
type: UnificationXref
id: O77627
db: uniprot

uniprot E1B8P9 52
type: UnificationXref
id: E1B8P9
db: uniprot

uniprot F1M9D0 39
type: UnificationXref
id: F1M9D0
db: uniprot

ncbitaxon 8364 57
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot B0BLZ8 281
type: UnificationXref
id: B0BLZ8
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 315
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot F7F5K9 155
type: UnificationXref
id: F7F5K9
db: uniprot

PTHR23050:SF385
type: RelationshipXref
id: PTHR23050:SF385
db: PANTHER Family
relationship type: By Homology

uniprot F7BYI4 79
type: UnificationXref
id: F7BYI4
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot A8KBH6 77
organism: Xenopus tropicalis

PTHR23050:SF381
type: RelationshipXref
id: PTHR23050:SF381
db: PANTHER Family
relationship type: By Homology

vav
type: ProteinReference
xref: P00368
standard name: Guanine nucleotide exchange factor VAV
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: vav Synonym: Synonym not specified Accession: P00368
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.vav
member entity reference: Vav guanine nucleotide exchange factor 3
member entity reference: Guanine nucleotide exchange factor VAV2 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Vav guanine nucleotide exchange factor 2
member entity reference: Guanine nucleotide exchange factor VAV2
member entity reference: VAV2 isoform 2
member entity reference: Guanine nucleotide exchange factor VAV3
member entity reference: Proto-oncogene vav
member entity reference: Vav guanine nucleotide exchange factor 1
member entity reference: VAV1 isoform 2

PTHR23050:SF383
type: RelationshipXref
id: PTHR23050:SF383
db: PANTHER Family
relationship type: By Homology

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot P25963 352
organism: Homo sapiens

uniprot P28482 64
type: UnificationXref
id: P28482
db: uniprot

uniprot H2QYW8 421
type: UnificationXref
id: H2QYW8
db: uniprot

Jnk
type: Protein
entity reference: Jnk
feature: ACTIVE 5
feature: Jnk s297 a287 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

IDA
type: EvidenceCodeVocabulary

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot F6X6I5 91
xref: PTHR24418:SF42
organism: Ornithorhynchus anatinus

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot Q14573 409
organism: Homo sapiens

Tyrosine-protein kinase
type: ProteinReference
xref: uniprot A0A3Q1MHG9 218
xref: PTHR24418:SF231
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1Q3M8 324
xref: PTHR10048:SF107
organism: Canis lupus familiaris

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q14571 408
xref: PTHR13715:SF53
organism: Homo sapiens

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

Ras
type: Protein
entity reference: Ras
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa36 494
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q5ZIF0 238
organism: Gallus gallus

Syk
type: Protein
entity reference: Syk
feature: Y Syk s46 a70 rs1
feature: Y Syk s46 a70 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CD22
type: Protein
entity reference: CD22
feature: Y CD22 s10 a10 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__CRAC-RIGHT__CRAC-_r30
control type: ACTIVATION
controller: Ca++

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H9FVU5 337
xref: PTHR10048:SF107
organism: Macaca mulatta

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36507 233
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot P36506 232
xref: PTHR48013:SF8
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r85 684
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

uniprot P63000 268
type: UnificationXref
id: P63000
db: uniprot

PARTICIPANT STOICHIOMETRY r85 683
type: Stoichiometry
physical entity: MEKK
stoichiometric coefficient: 1.0

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7BYI4 79
organism: Macaca mulatta

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

PTPRC isoform 2
type: ProteinReference
xref: PTHR19134:SF284
xref: uniprot H2Q0U9 372
organism: Pan troglodytes

uniprot P27870 30
type: UnificationXref
id: P27870
db: uniprot

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

Putative calmodulin
type: ProteinReference
xref: uniprot Q4QHT2 144
organism: Leishmania major

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 319
organism: Rattus norvegicus

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot F6Y841 328
xref: PTHR10048:SF33
organism: Canis lupus familiaris

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7668 151
type: UnificationXref
id: 7668
db: ncbitaxon

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF42
xref: uniprot E2RBB8 89
organism: Canis lupus familiaris

Calmodulin-1
type: ProteinReference
xref: uniprot Q0JNS6 142
xref: PTHR23050:SF438
organism: Oryza sativa

…
type: Stoichiometry
physical entity: mIgM
stoichiometric coefficient: 2.0

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot P62993 72
organism: Homo sapiens

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot P62994 73
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r43 620
type: Stoichiometry
physical entity: Complex (Ras/GTP/ Raf)
stoichiometric coefficient: 1.0

Raf
type: ProteinReference
xref: P00381
standard name: Raf Oncogene
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Raf
comment: ENTITY_REFERENCE_NOTES=Long Name: Raf Synonym: Synonym not specified Accession: P00381
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase B-raf
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: B-Raf proto-oncogene, serine/threonine kinase
member entity reference: A-Raf proto-oncogene, serine/threonine kinase

Ig-beta
type: Protein
entity reference: Ig-beta
feature: ACTIVE 5
feature: Y Ig beta s58 sa16 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa16 526
feature: Y Ig beta s58 sa16 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P01111 158
type: UnificationXref
id: P01111
db: uniprot

PARTICIPANT STOICHIOMETRY r64 657
type: Stoichiometry
physical entity: CD19
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6SW23 325
xref: PTHR10048:SF107
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r64 658
type: Stoichiometry
physical entity: CD19
stoichiometric coefficient: 1.0

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: uniprot Q91974 359
xref: PTHR46680:SF1
organism: Gallus gallus

PTHR45816:SF3
type: RelationshipXref
id: PTHR45816:SF3
db: PANTHER Family
relationship type: By Homology

uniprot F6SEH5 286
type: UnificationXref
id: F6SEH5
db: uniprot

uniprot F7DUD6 329
type: UnificationXref
id: F7DUD6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A3Q1MMD9 302
xref: PTHR10336:SF25
organism: Bos taurus

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q9WUI1 262
organism: Mus musculus

uniprot O16305 129
type: UnificationXref
id: O16305
db: uniprot

STATE_TRANSITION_LEFT__ATP-_Btk-RIGHT__ADP-_Btk-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 681
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 680
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 682
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 679
left: Btk
left: ATP
interaction type: STATE_TRANSITION
right: Btk
right: ADP

uniprot H2QGF1 413
type: UnificationXref
id: H2QGF1
db: uniprot

uniprot Q9TU25 278
type: UnificationXref
id: Q9TU25
db: uniprot

mIgM s52 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mIgM
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r43 619
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r43 618
type: Stoichiometry
physical entity: Complex (Ras/GTP)
stoichiometric coefficient: 1.0

ERK
type: Protein
entity reference: ERK
feature: Y ERK s131 a243 rs2
feature: T ERK s131 a243 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Calmodulin
type: Protein
entity reference: Calmodulin
feature: ACTIVE 5
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa33 464
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot H2QLZ4 401
xref: PTHR13715:SF53
organism: Pan troglodytes

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F6URW3 176
xref: PTHR23113:SF150
organism: Ornithorhynchus anatinus

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot H2QSU0 402
xref: PTHR13715:SF51
organism: Pan troglodytes

NFKB inhibitor like 1
type: ProteinReference
xref: uniprot Q5EAC4 353
xref: PTHR15263:SF1
organism: Bos taurus

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 140

Btk
type: Protein
entity reference: Btk
feature: ACTIVE 5
feature: Y Btk s66 a109 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

By Homology
type: RelationshipTypeVocabulary

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot Q63269 411
organism: Rattus norvegicus

uniprot Q61084 48
type: UnificationXref
id: Q61084
db: uniprot

IKK s267 a300 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P40259 166
type: UnificationXref
id: P40259
db: uniprot

BLNK
type: Protein
entity reference: BLNK
feature: Y BLNK s27 sa56 rs3
feature: Y BLNK s27 sa56 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa56 568
feature: Y BLNK s27 sa56 rs4
feature: Y BLNK s27 sa56 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24361:SF656
type: RelationshipXref
id: PTHR24361:SF656
db: PANTHER Family
relationship type: By Homology

uniprot Q6RUV5 276
type: UnificationXref
id: Q6RUV5
db: uniprot

Receptor-type tyrosine-protein phosphatase C
type: ProteinReference
xref: uniprot P04157 373
xref: PTHR19134:SF284
organism: Rattus norvegicus

Btk s320 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Btk
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 431
xref: PTHR24055:SF162
organism: Gallus gallus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot E2RQM0 303
organism: Canis lupus familiaris

IP3R
type: Protein
entity reference: IP3R
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Syk
type: Protein
entity reference: Syk
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa13 520
feature: Y Syk s51 sa13 rs1
feature: Y Syk s51 sa13 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

I kappa B s32 sa59 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: I kappa B
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q66JE6 240
xref: PTHR48013:SF5
organism: Xenopus tropicalis

mIgM s40 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mIgM
stoichiometric coefficient: 2.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 68
organism: Danio rerio

Tyrosine-protein phosphatase non-receptor type 6
type: ProteinReference
xref: uniprot P29350 167
xref: PTHR46257:SF4
organism: Homo sapiens

Tyrosine-protein phosphatase non-receptor type 6
type: ProteinReference
xref: uniprot P29351 169
xref: PTHR46257:SF4
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZCW7 399
xref: PTHR13715:SF53
organism: Monodelphis domestica

Complex (PKC/DAG)
type: Complex
component stoichiometry: PKC s20 sa50 STOICHIOMETRY ID COMPLEX
component stoichiometry: DAG s21 sa51 STOICHIOMETRY ID COMPLEX
component: DAG
component: PKC
feature: COMPLEX BINDING FEATURE s150 a266 491
feature: COMPLEX BINDING FEATURE s150 a266 489
cellular location: cytosol

uniprot P29994 405
type: UnificationXref
id: P29994
db: uniprot

uniprot P62152 139
type: UnificationXref
id: P62152
db: uniprot

uniprot F7BV42 93
type: UnificationXref
id: F7BV42
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot F1P630 436
organism: Canis lupus familiaris

uniprot A0A1D5QUZ8 51
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

Jnk s250 a284 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 57

SOS s68 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

IP3R
type: Protein
entity reference: IP3R
feature: ACTIVE 5
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

TRIGGER
type: RelationshipTypeVocabulary

GO GO:0005783 2
type: UnificationXref
id: GO:0005783
db: GO

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot H2R0G7 445
organism: Pan troglodytes

uniprot F7BWW9 178
type: UnificationXref
id: F7BWW9
db: uniprot

PLC gamma2
type: ProteinReference
xref: P00388
standard name: Phospholipase C gamma 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: PLC gamma2 Synonym: Phospholipase C gamma 2 Accession: P00388
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.PLC_br_gamma2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Lyn
type: Protein
entity reference: Lyn
feature: ACTIVE 5
feature: Y Lyn s301 a14 rs2
feature: Y Lyn s301 a14 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A2I3T7A8 317
xref: PTHR10048:SF107
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r22 679
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot O88995 351
type: UnificationXref
id: O88995
db: uniprot

STATE_TRANSITION_LEFT__GTP-_Complex__Ras_GDP__-RIGHT__GDP-_Complex__Ras_GTP_-_r42
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 624
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 626
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 625
participant stoichiometry: PARTICIPANT STOICHIOMETRY r42 627
left: GTP
left: Complex (Ras/GDP )
interaction type: STATE_TRANSITION
right: Complex (Ras/GTP)
right: GDP

STATE_TRANSITION_LEFT__Calcineurin-RIGHT__Calcineurin-_r37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 642
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 641
left: Calcineurin
interaction type: STATE_TRANSITION
right: Calcineurin

uniprot P12841 194
type: UnificationXref
id: P12841
db: uniprot

uniprot P70227 407
type: UnificationXref
id: P70227
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot P49186 448
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r22 680
type: Stoichiometry
physical entity: Btk
stoichiometric coefficient: 1.0

uniprot Q05144 270
type: UnificationXref
id: Q05144
db: uniprot

uniprot F1N261 90
type: UnificationXref
id: F1N261
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P49187 449
xref: PTHR24055:SF162
organism: Rattus norvegicus

DISSOCIATION_LEFT__Complex__Ras_Raf__MEK_GTP_-RIGHT__Complex__Ras_GTP__Raf_-_MEK-_r75
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 623
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 622
participant stoichiometry: PARTICIPANT STOICHIOMETRY r75 621
left: Complex (Ras/Raf/ MEK/GTP)
interaction type: DISSOCIATION
right: MEK
right: Complex (Ras/GTP/ Raf)

TRANSPORT_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r86
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 677
participant stoichiometry: PARTICIPANT STOICHIOMETRY r86 678
left: Ca++
interaction type: TRANSPORT
right: Ca++

PARTICIPANT STOICHIOMETRY r22 682
type: Stoichiometry
physical entity: Btk
stoichiometric coefficient: 1.0

Ig beta s42 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ig-beta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 681
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Ca_PLUS__PLUS_-RIGHT__Ca_PLUS__PLUS_-_r83
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 690
participant stoichiometry: PARTICIPANT STOICHIOMETRY r83 691
left: Ca++
interaction type: TRANSPORT
right: Ca++

Raf s74 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Raf
stoichiometric coefficient: 1.0

uniprot Q91974 359
type: UnificationXref
id: Q91974
db: uniprot

Fos proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot E2QYK5 189
organism: Canis lupus familiaris

uniprot P17325 429
type: UnificationXref
id: P17325
db: uniprot

Complex (Ras/GTP)
type: Complex
component stoichiometry: GTP s17 sa39 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ras s16 sa38 STOICHIOMETRY ID COMPLEX
component: Ras
component: GTP
feature: COMPLEX BINDING FEATURE s243 a229 573
feature: COMPLEX BINDING FEATURE s243 a229 571
cellular location: cytosol

ncbitaxon 45351 101
type: UnificationXref
id: 45351
db: ncbitaxon

uniprot Q6F332 146
type: UnificationXref
id: Q6F332
db: uniprot

Tyrosine-protein kinase SYK
type: ProteinReference
xref: uniprot P48025 222
xref: PTHR24418:SF231
organism: Mus musculus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot E1C2T7 282
organism: Gallus gallus

NF-kappa B
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot E2RMC0 394
xref: PTHR13715:SF51
organism: Canis lupus familiaris

Y Lyn s70 sa68 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s70 sa68 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.022723360841641067

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: PTHR45816:SF3
xref: uniprot A0A3Q1N7P8 391
organism: Bos taurus

uniprot P49187 449
type: UnificationXref
id: P49187
db: uniprot

uniprot Q9JHG7 346
type: UnificationXref
id: Q9JHG7
db: uniprot

Complex (BLNK/vav)
type: Complex
component stoichiometry: BLNK s27 sa56 STOICHIOMETRY ID COMPLEX
component stoichiometry: vav s30 sa57 STOICHIOMETRY ID COMPLEX
component: vav
component: BLNK
feature: COMPLEX BINDING FEATURE s157 a281 567
feature: COMPLEX BINDING FEATURE s157 a281 569
cellular location: cytosol

Bos taurus
type: BioSource
xref: ncbitaxon 9913 17

p38
type: Protein
entity reference: p38
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q02384 182
type: UnificationXref
id: Q02384
db: uniprot

Y CD19 s257 a290 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y CD19 s257 a290 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot A0A2I3T7A8 317
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

STATE_TRANSITION_LEFT__ATP-_jun-RIGHT__ADP-_jun-_r51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 692
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 693
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 695
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 694
left: jun
left: ATP
interaction type: STATE_TRANSITION
right: jun
right: ADP

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F7BVQ1 304
xref: PTHR10336:SF25
organism: Monodelphis domestica

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_r80
control type: ACTIVATION
controller: IP3

uniprot W4YPT6 152
type: UnificationXref
id: W4YPT6
db: uniprot

Complex (BLNK/Btk/ PLC gamma2/Grb2/ SOS)
type: Complex
component stoichiometry: Btk s64 sa22 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s68 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: PLC gamma2 s65 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s67 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: BLNK s63 sa21 STOICHIOMETRY ID COMPLEX
component: Btk
component: BLNK
component: PLC gamma2
component: Grb2
component: SOS
feature: COMPLEX BINDING FEATURE s76 a120 469
feature: COMPLEX BINDING FEATURE s76 a120 475
feature: COMPLEX BINDING FEATURE s76 a120 467
feature: COMPLEX BINDING FEATURE s76 a120 473
feature: COMPLEX BINDING FEATURE s76 a120 471
cellular location: cytosol

PARTICIPANT STOICHIOMETRY r13 609
type: Stoichiometry
physical entity: Complex (mIgM/Ig-alpha/ Ig-beta/Blk/ Btk/Lyn/ Syk)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 608
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 607
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q8CIH5 306
type: UnificationXref
id: Q8CIH5
db: uniprot

B-cell antigen receptor complex-associated protein alpha chain
type: ProteinReference
xref: PTHR14334:SF1
xref: uniprot P11912 415
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r13 606
type: Stoichiometry
physical entity: Complex (mIgM/Ig-alpha/ Ig-beta/Blk/ Btk/Lyn/ Syk)
stoichiometric coefficient: 1.0

B-cell antigen receptor complex-associated protein alpha chain
type: ProteinReference
xref: uniprot P11911 414
xref: PTHR14334:SF1
organism: Mus musculus

NF AT s122 a205 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Grb2
type: Protein
entity reference: Grb2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P31938 231
type: UnificationXref
id: P31938
db: uniprot

ACTIVE 5
type: EntityFeature
comment: Active state

Calmodulin-2
type: ProteinReference
xref: PTHR23050:SF385
xref: uniprot Q6F332 146
organism: Oryza sativa

uniprot F7HLC7 334
type: UnificationXref
id: F7HLC7
db: uniprot

uniprot A0A1D5PR76 371
type: UnificationXref
id: A0A1D5PR76
db: uniprot

Lyn s50 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Lyn
stoichiometric coefficient: 1.0

Guanine nucleotide exchange factor VAV3
type: ProteinReference
xref: uniprot Q9R0C8 34
xref: PTHR45818:SF1
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r73 632
type: Stoichiometry
physical entity: NF-kappa B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r75 622
type: Stoichiometry
physical entity: Complex (Ras/GTP/ Raf)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r75 621
type: Stoichiometry
physical entity: Complex (Ras/Raf/ MEK/GTP)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r73 631
type: Stoichiometry
physical entity: NF-kappa B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r75 623
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

MEK s235 a235 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Lyn
type: Protein
entity reference: Lyn
feature: ACTIVE 5
feature: Y Lyn s50 sa12 rs1
feature: Y Lyn s50 sa12 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa12 518
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Y Lyn s70 sa68 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s70 sa68 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot D4A3T0 170
type: UnificationXref
id: D4A3T0
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 7

PARTICIPANT STOICHIOMETRY r67 651
type: Stoichiometry
physical entity: Complex (NF-kappa B/I kappa B)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 642
type: Stoichiometry
physical entity: Calcineurin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 652
type: Stoichiometry
physical entity: NF-kappa B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r37 641
type: Stoichiometry
physical entity: Calcineurin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r67 653
type: Stoichiometry
physical entity: I kappa B
stoichiometric coefficient: 1.0

ncbitaxon 7227 140
type: UnificationXref
id: 7227
db: ncbitaxon

Pi
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q5PU49 88
xref: PTHR24356:SF365
organism: Canis lupus familiaris

Rac family small GTPase 1a
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q7ZSZ9 277
organism: Danio rerio

Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot H9FU38 403
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IKK-RIGHT__IKK-_r68
controller: Complex (PKC/DAG)

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot H9FU32 206
xref: PTHR44329:SF55
organism: Macaca mulatta

Ig alpha s54 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ig-alpha
stoichiometric coefficient: 1.0

Y CD22 s10 a10 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y CD22 s10 a10 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Vav guanine nucleotide exchange factor 3
type: ProteinReference
xref: PTHR45818:SF1
xref: uniprot A0A2I3TLP8 13
organism: Pan troglodytes

Raf
type: Protein
entity reference: Raf
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 sa42 548
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7B5L8 441
type: UnificationXref
id: F7B5L8
db: uniprot

uniprot Q5PU49 88
type: UnificationXref
id: Q5PU49
db: uniprot

IKK
type: Protein
entity reference: IKK
feature: IKK s262 a308 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot E2RCV1 322
xref: PTHR10048:SF34
organism: Canis lupus familiaris

uniprot Q63746 356
type: UnificationXref
id: Q63746
db: uniprot

uniprot P32871 340
type: UnificationXref
id: P32871
db: uniprot

MEKK
type: ProteinReference
xref: P00369
standard name: Mitogen-activated protein kinase kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: MEKK Synonym: MAP Kinase kinase kinase,MEK kinase Accession: P00369
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.MEKK
member entity reference: Uncharacterized protein
member entity reference: Map3k3 protein
member entity reference: Mitogen-activated protein kinase kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase kinase 3
member entity reference: MAP3K2 isoform 1
member entity reference: Mitogen-activated protein kinase kinase kinase 3 isoform 1

jun
type: ProteinReference
xref: P00401
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.jun
comment: ENTITY_REFERENCE_NOTES=Long Name: jun Synonym: Synonym not specified Accession: P00401
member entity reference: Transcription factor AP-1
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit

uniprot Q9Y2U5 50
type: UnificationXref
id: Q9Y2U5
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot Q02384 182
organism: Mus musculus

Tyrosine-protein kinase
type: ProteinReference
xref: PTHR24418:SF92
xref: uniprot E2RMF7 417
organism: Canis lupus familiaris

uniprot O00329 338
type: UnificationXref
id: O00329
db: uniprot

uniprot P43405 221
type: UnificationXref
id: P43405
db: uniprot

ncbitaxon 7955 69
type: UnificationXref
id: 7955
db: ncbitaxon

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot F2Z4P5 284
organism: Canis lupus familiaris

TRANSPORT_LEFT__p38-RIGHT__p38-_r77
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 611
participant stoichiometry: PARTICIPANT STOICHIOMETRY r77 610
left: p38
interaction type: TRANSPORT
right: p38

SOS s322 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6VXG1 326
xref: PTHR10048:SF107
organism: Xenopus tropicalis

PTHR14334:SF2
type: RelationshipXref
id: PTHR14334:SF2
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__Jnk-RIGHT__Jnk-_r78
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 604
participant stoichiometry: PARTICIPANT STOICHIOMETRY r78 605
left: Jnk
interaction type: TRANSPORT
right: Jnk

PTHR14334:SF1
type: RelationshipXref
id: PTHR14334:SF1
db: PANTHER Family
relationship type: By Homology

Lyn
type: Protein
entity reference: Lyn
feature: ACTIVE 5
feature: Y Lyn s70 sa68 rs1
feature: Y Lyn s70 sa68 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa68 500
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1MAI3 171
type: UnificationXref
id: F1MAI3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UD13 392
xref: PTHR13715:SF52
organism: Gallus gallus

uniprot A0A2I3RZ31 432
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

Jnk s297 a287 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MEK s35 sa62 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 143

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q63932 239
type: UnificationXref
id: Q63932
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot P01111 158
xref: PTHR24070:SF189
organism: Homo sapiens

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot P01112 159
organism: Homo sapiens

Protein kinase C delta type
type: ProteinReference
xref: uniprot P28867 85
xref: PTHR24356:SF365
organism: Mus musculus

Tyrosine-protein kinase Blk
type: ProteinReference
xref: uniprot P16277 312
xref: PTHR24418:SF181
organism: Mus musculus

uniprot P62149 138
type: UnificationXref
id: P62149
db: uniprot

Y BLNK s318 sa26 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s318 sa26 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7583620820412538
comment: MODIFICATION_RESIDUE_NAME=Y

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A2I3RZ31 432
xref: PTHR24055:SF162
organism: Pan troglodytes

Protein kinase C
type: ProteinReference
xref: uniprot F7A632 78
xref: PTHR24356:SF158
organism: Monodelphis domestica

GTP s36 sa63 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P01101 193
organism: Mus musculus

uniprot F6S9S9 227
type: UnificationXref
id: F6S9S9
db: uniprot

uniprot F6WX28 190
type: UnificationXref
id: F6WX28
db: uniprot

Proto-oncogene c-Fos
type: ProteinReference
xref: PTHR23351:SF4
xref: uniprot P01100 192
organism: Homo sapiens

ERK
type: ProteinReference
xref: P00371
standard name: Extracellular signal-regulated kinase
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.ERK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: ERK Synonym: Extracellular signal-regulated kinase Accession: P00371
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Uncharacterized protein

uniprot P79996 451
type: UnificationXref
id: P79996
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot Q91Y86 453
organism: Mus musculus

uniprot Q4KM97 313
type: UnificationXref
id: Q4KM97
db: uniprot

Y BLNK s318 sa26 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s318 sa26 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.426319326209974
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot P11911 414
type: UnificationXref
id: P11911
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9WTY9 261
xref: PTHR24055:SF107
organism: Rattus norvegicus

uniprot P36506 232
type: UnificationXref
id: P36506
db: uniprot

uniprot A0A2I3T4Q0 376
type: UnificationXref
id: A0A2I3T4Q0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK-_ATP-RIGHT__ADP-_ERK-_r48
controller: MEK

Ig-alpha
type: Protein
entity reference: Ig-alpha
feature: ACTIVE 5
feature: Y Ig alpha s45 sa8 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa8 510
feature: Y Ig alpha s45 sa8 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot H2R8U9 179
organism: Pan troglodytes

PTHR24418:SF92
type: RelationshipXref
id: PTHR24418:SF92
db: PANTHER Family
relationship type: By Homology

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 111

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

uniprot Q9QY78 389
type: UnificationXref
id: Q9QY78
db: uniprot

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

uniprot Q63269 411
type: UnificationXref
id: Q63269
db: uniprot

uniprot Q6P023 68
type: UnificationXref
id: Q6P023
db: uniprot

SOS
type: ProteinReference
xref: P00379
standard name: Son of sevenless
comment: ENTITY_REFERENCE_NOTES=Long Name: SOS Synonym: Son of Sevenless Accession: P00379
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.SOS
member entity reference: Son of sevenless homolog 2
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: Son of sevenless homolog 1
member entity reference: Uncharacterized protein

Y BLNK s318 sa26 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s318 sa26 rs4 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.528080903700913
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

PTHR24072:SF325
type: RelationshipXref
id: PTHR24072:SF325
db: PANTHER Family
relationship type: By Homology

uniprot E1BBD2 16
type: UnificationXref
id: E1BBD2
db: uniprot

Complex (mIgM/Ig-alpha/ Ig-beta)
type: Complex
component stoichiometry: Ig beta s42 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ig alpha s41 sa5 STOICHIOMETRY ID COMPLEX
component: mIgM
component: Ig-beta
component: Ig-alpha
feature: COMPLEX BINDING FEATURE s28 a33 487
feature: COMPLEX BINDING FEATURE s28 a33 485
feature: COMPLEX BINDING FEATURE s28 a33 483
cellular location: cytosol

GTP s73 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot G5E513 307
type: UnificationXref
id: G5E513
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__PIP2-RIGHT__DAG-_IP3-_r23
controller: Complex (BLNK/PLC gamma2/ Btk/Grb2/ SOS)

ERK
type: Protein
entity reference: ERK
feature: ACTIVE 5
feature: T ERK s132 a244 rs1
feature: Y ERK s132 a244 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Rac family small GTPase 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q5U1Y2 272
organism: Rattus norvegicus

Y PLC gamma2 s55 a90 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y PLC gamma2 s55 a90 rs1 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.010637896575541442

Y BLNK s318 sa26 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y BLNK s318 sa26 rs3 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.95137622615996

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1LTT9 242
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

Y Syk s62 sa20 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Syk s62 sa20 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.6585056029845953

mIgM
type: Protein
entity reference: mIgM

CD19 isoform 1
type: ProteinReference
xref: uniprot A0A2J8IJS0 362
xref: PTHR16674:SF2
organism: Pan troglodytes

NF kappa B inhibitor alpha (Fragment)
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot Q8WNW7 358
organism: Bos taurus

B cell activation; Differentiation into plasma cell
type: Pathway

uniprot P15391 364
type: UnificationXref
id: P15391
db: uniprot

Guanine nucleotide exchange factor VAV2
type: ProteinReference
xref: uniprot Q60992 33
xref: PTHR45818:SF4
organism: Mus musculus

Calmodulin
type: ProteinReference
xref: uniprot O16305 129
organism: Caenorhabditis elegans

uniprot A0A2I3SHP7 301
type: UnificationXref
id: A0A2I3SHP7
db: uniprot

HRAS isoform 2
type: ProteinReference
xref: uniprot K7ALD7 157
xref: PTHR24070:SF385
organism: Pan troglodytes

Lyn
type: Protein
entity reference: Lyn
feature: Y Lyn s1 a1 rs2
feature: Y Lyn s1 a1 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P68404 86
type: UnificationXref
id: P68404
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot O02812 249
organism: Canis lupus familiaris

PKC
type: ProteinReference
xref: P00373
standard name: Protein kinase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: PKC Synonym: Synonym not specified Accession: P00373
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.PKC
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_Complex__Ras_GDP__-RIGHT__GDP-_Complex__Ras_GTP_-_r42
controller: Complex (BLNK/PLC gamma2/ Btk/Grb2/ SOS)

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot C3ZEW0 114
organism: Branchiostoma floridae

PTHR24418:SF42
type: RelationshipXref
id: PTHR24418:SF42
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZEW2 115
organism: Branchiostoma floridae

uniprot Q5RKN6 74
type: UnificationXref
id: Q5RKN6
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__Ras_GTP__Raf_-_MEK-RIGHT__Complex__Ras_Raf__MEK_GTP_-_r74
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 628
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 629
participant stoichiometry: PARTICIPANT STOICHIOMETRY r74 630
left: MEK
left: Complex (Ras/GTP/ Raf)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Ras/Raf/ MEK/GTP)

Y ERK s132 a244 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y ERK s132 a244 rs2 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=-0.0

uniprot F6SHC1 379
type: UnificationXref
id: F6SHC1
db: uniprot

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 9
type: ProteinReference
xref: PTHR24055:SF172
xref: uniprot Q9WTU6 454
organism: Mus musculus

ncbitaxon 418459 118
type: UnificationXref
id: 418459
db: ncbitaxon

Grb2
type: ProteinReference
xref: P00372
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Grb2
comment: ENTITY_REFERENCE_NOTES=Long Name: Grb2 Synonym: Growth factor receptor-bound protein 2 Accession: P00372
member entity reference: Growth factor receptor-bound protein 2
member entity reference: GRB2-related adapter protein
member entity reference: Growth factor receptor-bound protein 2a

PTHR45673:SF1
type: RelationshipXref
id: PTHR45673:SF1
db: PANTHER Family
relationship type: By Homology

ncbitaxon 367110 296
type: UnificationXref
id: 367110
db: ncbitaxon

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
type: ProteinReference
xref: PTHR45673:SF7
xref: uniprot P16298 288
organism: Homo sapiens

PTHR45673:SF2
type: RelationshipXref
id: PTHR45673:SF2
db: PANTHER Family
relationship type: By Homology

BLNK
type: Protein
entity reference: BLNK
feature: Y BLNK s8 a86 rs3
feature: Y BLNK s8 a86 rs4
feature: Y BLNK s8 a86 rs1
feature: Y BLNK s8 a86 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

fos
type: ProteinReference
xref: P00380
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.fos
comment: ENTITY_REFERENCE_NOTES=Long Name: fos Synonym: c-fos Accession: P00380
member entity reference: Proto-oncogene c-Fos
member entity reference: C-fos
member entity reference: Fos proto-oncogene, AP-1 transcription factor subunit
member entity reference: Uncharacterized protein

…
type: Stoichiometry
physical entity: mIgM
stoichiometric coefficient: 2.0

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F1MX21 395
organism: Bos taurus

Vav guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR45818:SF4
xref: uniprot D3ZYG0 14
organism: Rattus norvegicus

PTHR45673:SF5
type: RelationshipXref
id: PTHR45673:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q02750 235
type: UnificationXref
id: Q02750
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 151

PTHR45673:SF7
type: RelationshipXref
id: PTHR45673:SF7
db: PANTHER Family
relationship type: By Homology

fos
type: Protein
entity reference: fos
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9N272 260
organism: Pan troglodytes

Rac
type: ProteinReference
xref: P00385
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Rac
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Uncharacterized protein
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Rac family small GTPase 1b
member entity reference: Rac family small GTPase 1
member entity reference: Rac family small GTPase 2
member entity reference: GTPase cRac1A
member entity reference: Rac family small GTPase 1a
member entity reference: Rac family small GTPase 3b
member entity reference: Rac family small GTPase 3a

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF245
xref: uniprot C3ZEV9 112
organism: Branchiostoma floridae

Y Syk s62 sa20 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Syk s62 sa20 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.6188115798754845
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

uniprot D4A5Q1 320
type: UnificationXref
id: D4A5Q1
db: uniprot

uniprot F7FDA0 331
type: UnificationXref
id: F7FDA0
db: uniprot

uniprot H2QDN0 44
type: UnificationXref
id: H2QDN0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot F6TXC2 245
organism: Monodelphis domestica

uniprot F1MYM3 323
type: UnificationXref
id: F1MYM3
db: uniprot

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9258 92
type: UnificationXref
id: 9258
db: ncbitaxon

MEK
type: Protein
entity reference: MEK
feature: ACTIVE 5
feature: MEK s247 a234 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F6S9S9 227
organism: Monodelphis domestica

uniprot H9FVU5 337
type: UnificationXref
id: H9FVU5
db: uniprot

uniprot F6Q932 285
type: UnificationXref
id: F6Q932
db: uniprot

uniprot E2REI6 203
type: UnificationXref
id: E2REI6
db: uniprot

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

Lyn s70 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Lyn
stoichiometric coefficient: 1.0

uniprot Q4QHT2 144
type: UnificationXref
id: Q4QHT2
db: uniprot

uniprot F7EYN2 365
type: UnificationXref
id: F7EYN2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot A0A3Q1LTT9 242
organism: Bos taurus

Ig-beta
type: Protein
entity reference: Ig-beta
feature: ACTIVE 5
feature: Y Ig beta s47 sa9 rs1
feature: Y Ig beta s47 sa9 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa9 512
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot A0A1D5QUZ8 51
organism: Macaca mulatta

uniprot P15498 28
type: UnificationXref
id: P15498
db: uniprot

Evidence 196
type: Evidence
evidence code: ISS
comment: SPACC P04049

NF-kappa B
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3SSC7 390
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

Evidence 197
type: Evidence
evidence code: ISS
comment: SPACC P05625

Evidence 198
type: Evidence
evidence code: ISS
comment: SPACC P11345

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot Q61084 48
organism: Mus musculus

Evidence 199
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: PTHR24361:SF342
xref: uniprot Q61083 46
organism: Mus musculus

B-cell linker protein
type: ProteinReference
xref: uniprot Q9YGC1 370
xref: PTHR14098:SF3
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EYN2 365
xref: PTHR14098:SF3
organism: Macaca mulatta

uniprot P01100 192
type: UnificationXref
id: P01100
db: uniprot

uniprot E2RMF7 417
type: UnificationXref
id: E2RMF7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot P16885 305
organism: Homo sapiens

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 132

uniprot E2RGT8 18
type: UnificationXref
id: E2RGT8
db: uniprot

Rac s22 sa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

uniprot F7F3S0 330
type: UnificationXref
id: F7F3S0
db: uniprot

PTHR23050:SF245
type: RelationshipXref
id: PTHR23050:SF245
db: PANTHER Family
relationship type: By Homology

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q05144 270
xref: PTHR24072:SF169
organism: Mus musculus

Calcineurin
type: ProteinReference
xref: P00386
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Calcineurin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Calcineurin Synonym: Synonym not specified Accession: P00386
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
member entity reference: Serine/threonine-protein phosphatase
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

uniprot F1Q3M8 324
type: UnificationXref
id: F1Q3M8
db: uniprot

PTHR15263:SF1
type: RelationshipXref
id: PTHR15263:SF1
db: PANTHER Family
relationship type: By Homology

I kappa B
type: ProteinReference
xref: P00392
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.I kappa B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: I kappa B Synonym: IkB,Inhibitor of NF-kappa B Accession: P00392
member entity reference: NFKB inhibitor like 1
member entity reference: NF-kappa-B inhibitor alpha
member entity reference: NF-kappa-B inhibitor-like protein 1
member entity reference: NFKB inhibitor alpha
member entity reference: Uncharacterized protein
member entity reference: V-type proton ATPase subunit G 2
member entity reference: NF kappa B inhibitor alpha (Fragment)

uniprot E2RNA9 378
type: UnificationXref
id: E2RNA9
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 101

uniprot E3KLJ3 117
type: UnificationXref
id: E3KLJ3
db: uniprot

Syk
type: Protein
entity reference: Syk
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 sa20 534
feature: Y Syk s62 sa20 rs1
feature: Y Syk s62 sa20 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Syk
type: ProteinReference
xref: P00382
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Syk Synonym: Synonym not specified Accession: P00382
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Syk
member entity reference: Tyrosine-protein kinase
member entity reference: Tyrosine-protein kinase SYK
member entity reference: Uncharacterized protein

GRB2-related adapter protein
type: ProteinReference
xref: uniprot A6QLK6 70
organism: Bos taurus

Ig-alpha
type: ProteinReference
xref: P00399
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Ig-alpha
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: B-cell antigen receptor complex-associated protein alpha chain
member entity reference: CD79A isoform 1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A1D5QLW6 300
xref: PTHR10336:SF25
organism: Macaca mulatta

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa39 574
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P53778 253
type: UnificationXref
id: P53778
db: uniprot

jun
type: Protein
entity reference: jun
feature: jun s145 a259 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot F7A818 400
type: UnificationXref
id: F7A818
db: uniprot

PI3K
type: Protein
entity reference: PI3K
feature: COMPLEX PARTICIPANT BINDING FEATURE s71 sa69 502
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot H2QLB4 60
organism: Pan troglodytes

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot Q04982 215
xref: PTHR44329:SF47
organism: Gallus gallus

uniprot P05412 427
type: UnificationXref
id: P05412
db: uniprot

TRUNCATION_LEFT__PIP2-RIGHT__DAG-_IP3-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 676
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 675
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 674
left: PIP2
interaction type: TRUNCATION
right: IP3
right: DAG

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

uniprot I2CU78 27
type: UnificationXref
id: I2CU78
db: uniprot

Rac
type: Protein
entity reference: Rac
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa54 460
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O02812 249
type: UnificationXref
id: O02812
db: uniprot

uniprot C3ZEW2 115
type: UnificationXref
id: C3ZEW2
db: uniprot

SHP-1
type: ProteinReference
xref: P00378
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.SHP-1
comment: ENTITY_REFERENCE_NOTES=Long Name: SHP-1 Synonym: SH2 domain-containing phosphatase Accession: P00378
member entity reference: Tyrosine-protein phosphatase non-receptor type 6

Uncharacterized protein
type: ProteinReference
xref: PTHR23050:SF427
xref: uniprot F7D7P2 126
organism: Monodelphis domestica

uniprot A0A3Q1MMD9 302
type: UnificationXref
id: A0A3Q1MMD9
db: uniprot

NFKB inhibitor alpha
type: ProteinReference
xref: PTHR46680:SF1
xref: uniprot H2Q867 350
organism: Pan troglodytes

Tyrosine-protein kinase BTK
type: ProteinReference
xref: PTHR24418:SF92
xref: uniprot Q06187 423
organism: Homo sapiens

uniprot Q8WV28 368
type: UnificationXref
id: Q8WV28
db: uniprot

uniprot H2QIN7 45
type: UnificationXref
id: H2QIN7
db: uniprot

PARTICIPANT STOICHIOMETRY r32 654
type: Stoichiometry
physical entity: CD22
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r32 656
type: Stoichiometry
physical entity: Complex (SHP-1/CD22)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r32 655
type: Stoichiometry
physical entity: SHP-1
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

uniprot H9FYU7 180
type: UnificationXref
id: H9FYU7
db: uniprot

uniprot J9NWQ5 127
type: UnificationXref
id: J9NWQ5
db: uniprot

ncbitaxon 3218 106
type: UnificationXref
id: 3218
db: ncbitaxon

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q16539 256
organism: Homo sapiens

Calmodulin
type: ProteinReference
xref: PTHR23050:SF424
xref: uniprot Q6PI52 147
organism: Danio rerio

uniprot E2RMC0 394
type: UnificationXref
id: E2RMC0
db: uniprot

Ig alpha s38 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ig-alpha
stoichiometric coefficient: 1.0

uniprot F7D7P2 126
type: UnificationXref
id: F7D7P2
db: uniprot

uniprot Q95NE7 259
type: UnificationXref
id: Q95NE7
db: uniprot

uniprot F2Z4P5 284
type: UnificationXref
id: F2Z4P5
db: uniprot

STATE_TRANSITION_LEFT__MEKK-RIGHT__MEKK-_r84
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 685
participant stoichiometry: PARTICIPANT STOICHIOMETRY r84 686
left: MEKK
interaction type: STATE_TRANSITION
right: MEKK

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot B0BLZ8 281
organism: Xenopus tropicalis

Complex (BLNK/PLC gamma2/ Btk/Grb2/ SOS)
type: Complex
component stoichiometry: Btk s320 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s321 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s322 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: PLC gamma2 s319 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: BLNK s318 sa26 STOICHIOMETRY ID COMPLEX
component: SOS
component: Grb2
component: PLC gamma2
component: BLNK
component: Btk
feature: COMPLEX BINDING FEATURE s317 a145 563
feature: COMPLEX BINDING FEATURE s317 a145 561
feature: COMPLEX BINDING FEATURE s317 a145 559
feature: COMPLEX BINDING FEATURE s317 a145 565
feature: COMPLEX BINDING FEATURE s317 a145 557
cellular location: cytosol

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot E2R6T4 425
xref: PTHR11462:SF8
organism: Canis lupus familiaris

DISSOCIATION_LEFT__Complex__NF_kappa_B_I_kappa_B_-RIGHT__NF_kappa_B-_I_kappa_B-_r67
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 651
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 652
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 653
left: Complex (NF-kappa B/I kappa B)
interaction type: DISSOCIATION
right: I kappa B
right: NF-kappa B

uniprot Q9XT09 241
type: UnificationXref
id: Q9XT09
db: uniprot

I kappa B s32 sa59 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Y Lyn s1 a1 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s1 a1 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P40293 416
type: UnificationXref
id: P40293
db: uniprot

Jnk s251 a285 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45673:SF5
xref: uniprot F7DKU1 287
organism: Monodelphis domestica

uniprot H2PZQ7 156
type: UnificationXref
id: H2PZQ7
db: uniprot

Ras s72 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot Q62245 186
type: UnificationXref
id: Q62245
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__DAG-_PKC-RIGHT__Complex__PKC_DAG_-_r52
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 689
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 688
participant stoichiometry: PARTICIPANT STOICHIOMETRY r52 687
left: PKC
left: DAG
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PKC/DAG)

PIK3CG isoform 1
type: ProteinReference
xref: uniprot A0A2J8QY32 318
xref: PTHR10048:SF34
organism: Pan troglodytes

PLC gamma2
type: Protein
entity reference: PLC gamma2
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa23 472
feature: Y PLC gamma2 s65 sa23 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Monosiga brevicollis
type: BioSource
xref: ncbitaxon 81824 109

Syk s62 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Syk
stoichiometric coefficient: 1.0

Y Lyn s1 a1 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Lyn s1 a1 rs2 Y
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.022723360841641067