SOS Ras/Rac guanine nucleotide exchange factor 1
Dual specificity mitogen-activated protein kinase kinase 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Dual-specificity mitogen-activated protein kinase kinase 2
Complex (mIgM/Ig-alpha/ Ig-beta/Blk/ Btk/Lyn/ Syk)
Inhibitor of nuclear factor kappa B kinase subunit beta
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
A-Raf proto-oncogene, serine/threonine kinase
Conserved helix-loop-helix ubiquitous kinase
Inositol 1,4,5-trisphosphate receptor type 1
Mitogen-activated protein kinase kinase kinase 3
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.IKK
ENTITY_REFERENCE_NOTES=Long Name: IKK Synonym: IKBK,Inhibitor of Kappa B kinase Accession: P00397
ENTITY_REFERENCE_NOTES=Long Name: CD45 Synonym: Leukocyte common antigen Accession: P00396
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.CD45
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.RECEPTOR.mIgM
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Calmodulin
ENTITY_REFERENCE_NOTES=Long Name: Calmodulin Synonym: CaM Accession: P00375
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Ras
Ras-related C3 botulinum toxin substrate 1
Vav guanine nucleotide exchange factor 1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Inhibitor of nuclear factor kappa-B kinase subunit beta
Inositol 1,4,5-trisphosphate receptor type 3
B-Raf proto-oncogene, serine/threonine kinase
Raf-1 proto-oncogene, serine/threonine kinase
Inositol 1,4,5-trisphosphate receptor type 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Ig-beta
Mitogen-activated protein kinase kinase kinase 3 isoform 1
Vav guanine nucleotide exchange factor 3
Inhibitor of nuclear factor kappa-B kinase subunit alpha
-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.MEK
ENTITY_REFERENCE_NOTES=Long Name: MEK Synonym: MAP kinase kinase,MAPK/ERK Kinase Accession: P00383
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.CD22
ENTITY_REFERENCE_NOTES=Long Name: CD22 Synonym: Synonym not specified Accession: P00387
Dual specificity mitogen-activated protein kinase kinase 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
SOS Ras/Rho guanine nucleotide exchange factor 2
ENTITY_REFERENCE_NOTES=Long Name: BLNK Synonym: B Cell Linker Protein,BASH,SLP-65 Accession: P00394
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.BLNK
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
ENTITY_REFERENCE_NOTES=Long Name: IP3R Synonym: IP3 Receptor,Inositol (3,4,5) triphosphate Receptor Accession: P00398
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.ION_CHANNEL.IP3R
Mitogen-activated protein kinase kinase 1
ENTITY_REFERENCE_NOTES=Long Name: Lyn Synonym: Synonym not specified Accession: P00374
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Lyn
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Blk
ENTITY_REFERENCE_NOTES=Long Name: Blk Synonym: p55blk Accession: P00390
B-cell antigen receptor complex-associated protein beta chain
Mitogen-activated protein kinase kinase kinase 2
RAF proto-oncogene serine/threonine-protein kinase
Mitogen-activated protein kinase kinase 2
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.CD19
ENTITY_REFERENCE_NOTES=Long Name: CD19 Synonym: Synonym not specified Accession: P00393
Harvey rat sarcoma viral oncogene homolog
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
MODEL_NOTES=Panther Pathway: P00010 B cell activation entails the process by which a pre-B cell matures into a plasma cell. The signaling pathways that regulate this conversion are complex, but center around a complex of proteins referred to as the B cell receptor, or BCR. Ligation of the BCR by a cognate antigen initiates a number of downstream signaling events that lead, eventually, to an expansion in the number of B cells of the appropriate antigen specificity, and to their development of the ability to secrete antibody. Medline=11913948 Medline=12040177 Medline=12119152 PMID: 11913948 PMID: 12040177 PMID: 12119152
Ras-related C3 botulinum toxin substrate 2
B-cell antigen receptor complex-associated protein alpha chain
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Jnk
ENTITY_REFERENCE_NOTES=Long Name: Jnk Synonym: Jun Kinase Accession: P00402
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
ENTITY_REFERENCE_NOTES=Long Name: Btk Synonym: bruton's tyrosine kinase Accession: P00400
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Btk
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.PI3K
ENTITY_REFERENCE_NOTES=Long Name: PI3K Synonym: Phosphatidyl inositol 3-kinase Accession: P00391
Guanine nucleotide exchange factor VAV2 isoform 1
Serine/threonine-protein phosphatase 2B catalytic subunit
Receptor-type tyrosine-protein phosphatase C
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.p38
ENTITY_REFERENCE_NOTES=Long Name: p38 Synonym: MAP kinase Accession: P00384
ENTITY_REFERENCE_NOTES=Long Name: vav Synonym: Synonym not specified Accession: P00368
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.vav
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Raf
ENTITY_REFERENCE_NOTES=Long Name: Raf Synonym: Synonym not specified Accession: P00381
Tyrosine-protein phosphatase non-receptor type 6
ENTITY_REFERENCE_NOTES=Long Name: PLC gamma2 Synonym: Phospholipase C gamma 2 Accession: P00388
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.PLC_br_gamma2
Fos proto-oncogene, AP-1 transcription factor subunit
Complex (BLNK/Btk/ PLC gamma2/Grb2/ SOS)
Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Mitogen-activated protein kinase kinase kinase
ENTITY_REFERENCE_NOTES=Long Name: MEKK Synonym: MAP Kinase kinase kinase,MEK kinase Accession: P00369
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.MEKK
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.jun
ENTITY_REFERENCE_NOTES=Long Name: jun Synonym: Synonym not specified Accession: P00401
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.ERK
ENTITY_REFERENCE_NOTES=Long Name: ERK Synonym: Extracellular signal-regulated kinase Accession: P00371
ENTITY_REFERENCE_NOTES=Long Name: SOS Synonym: Son of Sevenless Accession: P00379
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.SOS
B cell activation; Differentiation into plasma cell
ENTITY_REFERENCE_NOTES=Long Name: PKC Synonym: Synonym not specified Accession: P00373
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.PKC
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Grb2
ENTITY_REFERENCE_NOTES=Long Name: Grb2 Synonym: Growth factor receptor-bound protein 2 Accession: P00372
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.fos
ENTITY_REFERENCE_NOTES=Long Name: fos Synonym: c-fos Accession: P00380
Vav guanine nucleotide exchange factor 2
Ras-related C3 botulinum toxin substrate
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Rac
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Calcineurin
ENTITY_REFERENCE_NOTES=Long Name: Calcineurin Synonym: Synonym not specified Accession: P00386
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.I kappa B
ENTITY_REFERENCE_NOTES=Long Name: I kappa B Synonym: IkB,Inhibitor of NF-kappa B Accession: P00392
ENTITY_REFERENCE_NOTES=Long Name: Syk Synonym: Synonym not specified Accession: P00382
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Syk
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.Ig-alpha
ENTITY_REFERENCE_ID_DESC=B cell activation.PROTEIN.GENERIC.SHP-1
ENTITY_REFERENCE_NOTES=Long Name: SHP-1 Synonym: SH2 domain-containing phosphatase Accession: P00378
Complex (BLNK/PLC gamma2/ Btk/Grb2/ SOS)
Jun proto-oncogene, AP-1 transcription factor subunit