uniprot Q5TZ66 91
type: UnificationXref
id: Q5TZ66
db: uniprot

Heart Rate
type: Pathway

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re20
control type: ACTIVATION
controller: ER-type Ca2+ channel

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: uniprot M9PE71 53
xref: PTHR45701:SF3
organism: Drosophila melanogaster

uniprot P36408 205
type: UnificationXref
id: P36408
db: uniprot

ncbitaxon 214684 247
type: UnificationXref
id: 214684
db: ncbitaxon

Beta1 s7 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta1
stoichiometric coefficient: 1.0

uniprot F7FXA9 176
type: UnificationXref
id: F7FXA9
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 249
organism: Gallus gallus

uniprot P62881 224
type: UnificationXref
id: P62881
db: uniprot

Syntaxin-3
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q64704 95
organism: Mus musculus

uniprot P16520 197
type: UnificationXref
id: P16520
db: uniprot

ADRB1 isoform 1
type: ProteinReference
xref: uniprot H2Q2L5 5
xref: PTHR24248:SF54
organism: Pan troglodytes

uniprot Q2KJD2 86
type: UnificationXref
id: Q2KJD2
db: uniprot

uniprot Q7PXP3 263
type: UnificationXref
id: Q7PXP3
db: uniprot

uniprot Q61017 252
type: UnificationXref
id: Q61017
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 119
organism: Bos taurus

uniprot Q6DGZ5 254
type: UnificationXref
id: Q6DGZ5
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q08462 344
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 227
organism: Bos taurus

ncbitaxon 3702 105
type: UnificationXref
id: 3702
db: ncbitaxon

Mus musculus
type: BioSource
xref: ncbitaxon 10090 14

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6XYX9 42
organism: Monodelphis domestica

PRKACB isoform 3
type: ProteinReference
xref: uniprot H2R1G3 295
xref: PTHR24353:SF116
organism: Pan troglodytes

uniprot Q5XGD8 248
type: UnificationXref
id: Q5XGD8
db: uniprot

PARTICIPANT STOICHIOMETRY re19 379
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa9 358
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Complex (GDP/G-Protein/_brBetasub_1/NE)
type: Complex
component stoichiometry: NE s11 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s9 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s76 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta1 s10 sa10 STOICHIOMETRY ID COMPLEX
component: GDP
component: Beta1
component: G-Protein
component: NE
feature: COMPLEX BINDING FEATURE s38 a53 359
feature: COMPLEX BINDING FEATURE s38 a53 357
feature: COMPLEX BINDING FEATURE s38 a53 355
feature: COMPLEX BINDING FEATURE s38 a53 361
cellular location: cytosol

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 222
organism: Homo sapiens

uniprot Q7Q5C3 264
type: UnificationXref
id: Q7Q5C3
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 310
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 221
organism: Mus musculus

uniprot P11017 196
type: UnificationXref
id: P11017
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 219
organism: Canis lupus familiaris

ncbitaxon 9598 6
type: UnificationXref
id: 9598
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 220
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 224
organism: Mus musculus

uniprot H2R1G3 295
type: UnificationXref
id: H2R1G3
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 223
organism: Mus musculus

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: uniprot F6T0T9 288
xref: PTHR24353:SF116
organism: Xenopus tropicalis

uniprot P63214 229
type: UnificationXref
id: P63214
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot F6UFJ7 38
organism: Macaca mulatta

uniprot Q9N0Y0 106
type: UnificationXref
id: Q9N0Y0
db: uniprot

Ca2+ channel
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 148

uniprot F6Z5I2 44
type: UnificationXref
id: F6Z5I2
db: uniprot

uniprot A5PKD6 121
type: UnificationXref
id: A5PKD6
db: uniprot

uniprot A8XW88 280
type: UnificationXref
id: A8XW88
db: uniprot

PTHR10218:SF320
type: RelationshipXref
id: PTHR10218:SF320
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 218
organism: Bos taurus

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F1LQT1 335
organism: Rattus norvegicus

uniprot H2QNS5 187
type: UnificationXref
id: H2QNS5
db: uniprot

uniprot F6ZAV4 338
type: UnificationXref
id: F6ZAV4
db: uniprot

uniprot Q9SD96 108
type: UnificationXref
id: Q9SD96
db: uniprot

ncbitaxon 367110 148
type: UnificationXref
id: 367110
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 168
organism: Macaca mulatta

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60879 71
organism: Mus musculus

ncbitaxon 6238 27
type: UnificationXref
id: 6238
db: ncbitaxon

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60878 69
xref: PTHR19305:SF5
organism: Gallus gallus

uniprot Q9W3J1 277
type: UnificationXref
id: Q9W3J1
db: uniprot

uniprot Q6DF43 253
type: UnificationXref
id: Q6DF43
db: uniprot

uniprot G3V6P8 181
type: UnificationXref
id: G3V6P8
db: uniprot

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 88
organism: Emericella nidulans

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60877 68
xref: PTHR19305:SF5
organism: Macaca mulatta

uniprot Q13277 82
type: UnificationXref
id: Q13277
db: uniprot

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 248
organism: Xenopus tropicalis

uniprot E2R2S3 132
type: UnificationXref
id: E2R2S3
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 6

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60880 72
xref: PTHR19305:SF5
organism: Homo sapiens

P04435
type: UnificationXref
id: P04435
db: PANTHER Pathway Component

uniprot Q9UBI6 275
type: UnificationXref
id: Q9UBI6
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q2KJD2 86
organism: Bos taurus

P04436
type: UnificationXref
id: P04436
db: PANTHER Pathway Component

P04433
type: UnificationXref
id: P04433
db: PANTHER Pathway Component

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Heart Rate
controller: Ca2+

uniprot Q6TH03 261
type: UnificationXref
id: Q6TH03
db: uniprot

uniprot Q5BK52 324
type: UnificationXref
id: Q5BK52
db: uniprot

P04437
type: UnificationXref
id: P04437
db: PANTHER Pathway Component

P04439
type: UnificationXref
id: P04439
db: PANTHER Pathway Component

uniprot F7CB49 166
type: UnificationXref
id: F7CB49
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68182 320
xref: PTHR24353:SF116
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 372
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 371
left: PKA
interaction type: STATE_TRANSITION
right: PKA

uniprot F5HH30 147
type: UnificationXref
id: F5HH30
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68181 319
xref: PTHR24353:SF116
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63044 77
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot P63045 78
xref: PTHR45701:SF5
organism: Rattus norvegicus

Beta1
type: Protein
entity reference: Beta1
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa7 368
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24248:SF54
type: RelationshipXref
id: PTHR24248:SF54
db: PANTHER Family
relationship type: By Homology

Synaptobrevin-1
type: ProteinReference
xref: uniprot O02495 56
xref: PTHR45701:SF3
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: uniprot A1L271 118
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 126
organism: Branchiostoma floridae

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re11
control type: ACTIVATION
controller: PKA

Vesicle-associated membrane protein 8 (Endobrevin)
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q7ZUC1 99
organism: Danio rerio

uniprot Q9BV40 102
type: UnificationXref
id: Q9BV40
db: uniprot

PARTICIPANT STOICHIOMETRY re19 382
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 381
type: Stoichiometry
physical entity: Complex (Beta1/NE)
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Heart Rate
controller: Ca2+

uniprot Q7Q6D2 265
type: UnificationXref
id: Q7Q6D2
db: uniprot

PARTICIPANT STOICHIOMETRY re19 380
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/_brBetasub_1/NE)
stoichiometric coefficient: 1.0

uniprot A1L271 118
type: UnificationXref
id: A1L271
db: uniprot

uniprot Q9LMG8 104
type: UnificationXref
id: Q9LMG8
db: uniprot

Protein kinase A catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q27687 322
organism: Leishmania major

PARTICIPANT STOICHIOMETRY re19 383
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63027 76
organism: Homo sapiens

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63026 75
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re17 389
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

uniprot F6W548 156
type: UnificationXref
id: F6W548
db: uniprot

uniprot A4IGZ2 120
type: UnificationXref
id: A4IGZ2
db: uniprot

ncbitaxon 8364 37
type: UnificationXref
id: 8364
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re17 390
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 73
organism: Mus musculus

uniprot Q15KE4 238
type: UnificationXref
id: Q15KE4
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63025 74
organism: Rattus norvegicus

uniprot F6XWE8 159
type: UnificationXref
id: F6XWE8
db: uniprot

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 149
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(olf) subunit alpha
type: ProteinReference
xref: uniprot Q8CGK7 270
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 134
organism: Canis lupus familiaris

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot O70404 60
xref: PTHR45701:SF7
organism: Mus musculus

VAMP2 isoform 3
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot H2RCB8 52
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 194
organism: Homo sapiens

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot F6Z5I2 44
xref: PTHR45701:SF7
organism: Monodelphis domestica

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re12
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 391
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 392
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

uniprot A0A3Q1LYB4 22
type: UnificationXref
id: A0A3Q1LYB4
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__NE-RIGHT__NE-_re2
control type: ACTIVATION
controller: SNARE COMPLEX

G Protein s6 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P21137 311
xref: PTHR24353:SF117
organism: Caenorhabditis elegans

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 133
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 132
organism: Canis lupus familiaris

uniprot P29387 202
type: UnificationXref
id: P29387
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 18

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: uniprot Q6DBV8 325
xref: PTHR24353:SF135
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, beta a
type: ProteinReference
xref: uniprot Q7T374 329
xref: PTHR24353:SF116
organism: Danio rerio

Beta1
type: ProteinReference
xref: P04433
standard name: Beta1 adrenergic receptor
comment: ENTITY_REFERENCE_ID_DESC=Beta1 adrenergic receptor signaling pathway.PROTEIN.RECEPTOR.Beta_sub_1
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Beta-1 adrenergic receptor
member entity reference: ADRB1 isoform 1

uniprot F7E427 170
type: UnificationXref
id: F7E427
db: uniprot

uniprot Q7Q6D3 266
type: UnificationXref
id: Q7Q6D3
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__NE-_Complex__GDP_G_Protein__brBetasub_1_-RIGHT__Complex__GDP_G_Protein__brBetasub_1_NE_-_re18
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 388
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 386
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 387
left: NE
left: Complex (GDP/G-Protein/_brBetasub_1)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-Protein/_brBetasub_1/NE)

uniprot Q64704 95
type: UnificationXref
id: Q64704
db: uniprot

uniprot O09044 57
type: UnificationXref
id: O09044
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot O95721 61
organism: Homo sapiens

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: uniprot E2RRD1 282
xref: PTHR11635:SF153
organism: Canis lupus familiaris

uniprot P22694 313
type: UnificationXref
id: P22694
db: uniprot

AGAP006521-PA
type: ProteinReference
xref: uniprot Q7Q5C3 264
organism: Anopheles gambiae

uniprot Q3T0Y8 87
type: UnificationXref
id: Q3T0Y8
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot A8XW88 280
xref: PTHR24353:SF117
organism: Caenorhabditis briggsae

uniprot P60878 69
type: UnificationXref
id: P60878
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 210
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 211
organism: Homo sapiens

uniprot P60879 71
type: UnificationXref
id: P60879
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot A0A3Q1LYB4 22
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 213
organism: Bos taurus

uniprot R4GKD1 278
type: UnificationXref
id: R4GKD1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 212
organism: Mus musculus

DISSOCIATION_LEFT__GTP-_Complex__GDP_G_Protein__brBetasub_1_NE_-RIGHT__Complex__Beta1_NE_-_GDP-_Complex__GTP_G_Protein_-_re19
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 383
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 379
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 382
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 381
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 380
left: Complex (GDP/G-Protein/_brBetasub_1/NE)
left: GTP
interaction type: DISSOCIATION
right: Complex (GTP/G-Protein)
right: GDP
right: Complex (Beta1/NE)

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot A0A1D5QDW1 17
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M3D6 116
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot F6SED9 34
organism: Monodelphis domestica

uniprot F7DL70 339
type: UnificationXref
id: F7DL70
db: uniprot

uniprot P29829 203
type: UnificationXref
id: P29829
db: uniprot

uniprot A0A1D5QDW1 17
type: UnificationXref
id: A0A1D5QDW1
db: uniprot

uniprot Q5BH99 244
type: UnificationXref
id: Q5BH99
db: uniprot

uniprot P34971 13
type: UnificationXref
id: P34971
db: uniprot

uniprot Q6PBY0 258
type: UnificationXref
id: Q6PBY0
db: uniprot

uniprot F6PVT7 151
type: UnificationXref
id: F6PVT7
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P27791 314
organism: Rattus norvegicus

uniprot P62873 220
type: UnificationXref
id: P62873
db: uniprot

uniprot D3ZLD6 128
type: UnificationXref
id: D3ZLD6
db: uniprot

uniprot H2RI77 297
type: UnificationXref
id: H2RI77
db: uniprot

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6YMH2 43
organism: Macaca mulatta

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q9DAS9 273
type: UnificationXref
id: Q9DAS9
db: uniprot

uniprot P08588 9
type: UnificationXref
id: P08588
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9BV40 102
xref: PTHR45701:SF7
organism: Homo sapiens

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot K7ADQ0 340
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 181
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A943 45
xref: PTHR45701:SF5
organism: Monodelphis domestica

uniprot H2Q3W7 185
type: UnificationXref
id: H2Q3W7
db: uniprot

Soluble NSF attachment protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot P83351 79
organism: Caenorhabditis elegans

ncbitaxon 10090 14
type: UnificationXref
id: 10090
db: ncbitaxon

Beta1 s10 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta1
stoichiometric coefficient: 1.0

uniprot F1PJE5 144
type: UnificationXref
id: F1PJE5
db: uniprot

uniprot H2PZA6 183
type: UnificationXref
id: H2PZA6
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 186
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF320
xref: uniprot F6PV18 150
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 234
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 233
organism: Homo sapiens

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q503 286
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 232
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 231
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 230
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 229
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 228
organism: Mus musculus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 27

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 238
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 24

uniprot O70404 60
type: UnificationXref
id: O70404
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BS74 129
organism: Gallus gallus

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 203
organism: Drosophila melanogaster

uniprot H2RER5 296
type: UnificationXref
id: H2RER5
db: uniprot

uniprot E9FUX0 138
type: UnificationXref
id: E9FUX0
db: uniprot

ncbitaxon 284812 101
type: UnificationXref
id: 284812
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 175
organism: Macaca mulatta

uniprot P50154 213
type: UnificationXref
id: P50154
db: uniprot

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

ncbitaxon 9606 10
type: UnificationXref
id: 9606
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 272
organism: Mus musculus

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 135
organism: Canis lupus familiaris

uniprot E2R9G5 134
type: UnificationXref
id: E2R9G5
db: uniprot

Synaptobrevin
type: ProteinReference
xref: uniprot P18489 62
xref: PTHR45701:SF10
organism: Drosophila melanogaster

uniprot Q9ERB0 103
type: UnificationXref
id: Q9ERB0
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 108
organism: Arabidopsis thaliana

uniprot A0A2I3TUD1 115
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

uniprot F7EBE7 171
type: UnificationXref
id: F7EBE7
db: uniprot

Beta-1 adrenergic receptor
type: ProteinReference
xref: uniprot Q9TT96 15
xref: PTHR24248:SF54
organism: Bos taurus

uniprot P50151 211
type: UnificationXref
id: P50151
db: uniprot

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot W4YRI6 333
organism: Strongylocentrotus purpuratus

uniprot F7CXD0 169
type: UnificationXref
id: F7CXD0
db: uniprot

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 123

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 247

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 198
organism: Caenorhabditis elegans

Beta-1 adrenergic receptor
type: ProteinReference
xref: uniprot P18090 11
xref: PTHR24248:SF54
organism: Rattus norvegicus

uniprot P62880 223
type: UnificationXref
id: P62880
db: uniprot

PTHR24353:SF133
type: RelationshipXref
id: PTHR24353:SF133
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

uniprot Q3KRE3 242
type: UnificationXref
id: Q3KRE3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 243
organism: Bos taurus

uniprot P51817 318
type: UnificationXref
id: P51817
db: uniprot

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: uniprot Q5TZ66 91
xref: PTHR19305:SF5
organism: Danio rerio

NE
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa13 354
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

G protein subunit alpha L
type: ProteinReference
xref: uniprot F6XVE6 158
organism: Xenopus tropicalis

uniprot Q9CXP8 272
type: UnificationXref
id: Q9CXP8
db: uniprot

uniprot F6SED9 34
type: UnificationXref
id: F6SED9
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot A5PEW5 23
xref: PTHR19305:SF14
organism: Caenorhabditis elegans

PKA
type: ProteinReference
xref: P04437
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: PKA Synonym: protein kinase A Accession: P04437
comment: ENTITY_REFERENCE_ID_DESC=Beta1 adrenergic receptor signaling pathway.PROTEIN.GENERIC.PKA
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: Uncharacterized protein
member entity reference: Protein kinase A catalytic subunit isoform 2
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: PRKACG isoform 1
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: Protein kinase A catalytic subunit isoform 1
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta a
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: AGAP004940-PA
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: Protein kinase, X-linked
member entity reference: AGAP008039-PA (Fragment)
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit 3
member entity reference: cAMP-dependent protein kinase catalytic subunit PRKX
member entity reference: PRKAR2A isoform 1
member entity reference: Protein kinase A catalytic subunit
member entity reference: PRKACB isoform 3
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: AGAP001384-PA
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1

ncbitaxon 227321 89
type: UnificationXref
id: 227321
db: ncbitaxon

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 127

uniprot Q5BJ11 245
type: UnificationXref
id: Q5BJ11
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6SSS3 152
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 184
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 156
organism: Macaca mulatta

sarcoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0016529 3

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 214
organism: Rattus norvegicus

uniprot Q6R0H7 260
type: UnificationXref
id: Q6R0H7
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6UBJ8 36
xref: PTHR19305:SF4
organism: Xenopus tropicalis

Synaptobrevin homolog 2
type: ProteinReference
xref: uniprot P33328 66
organism: Saccharomyces cerevisiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re17
controller: Complex (GTP/G-Protein)

uniprot H2QZN8 188
type: UnificationXref
id: H2QZN8
db: uniprot

uniprot A3KMS9 279
type: UnificationXref
id: A3KMS9
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P00515 300
organism: Bos taurus

PTHR24353:SF128
type: RelationshipXref
id: PTHR24353:SF128
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P00517 301
organism: Bos taurus

uniprot A0A1D5QIS2 19
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

Syntaxin-3
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q13277 82
organism: Homo sapiens

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 35

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 191
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 130
organism: Gallus gallus

muscle contraction
type: Pathway

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6VUT7 40
xref: PTHR19305:SF5
organism: Ornithorhynchus anatinus

uniprot O44419 58
type: UnificationXref
id: O44419
db: uniprot

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O00161 55
organism: Homo sapiens

uniprot A0A1D5RHE7 334
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

uniprot F6YMH2 43
type: UnificationXref
id: F6YMH2
db: uniprot

uniprot O00161 55
type: UnificationXref
id: O00161
db: uniprot

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

uniprot P12367 304
type: UnificationXref
id: P12367
db: uniprot

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

Beta1
type: Protein
entity reference: Beta1
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa10 360
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6PGC8 149
type: UnificationXref
id: F6PGC8
db: uniprot

uniprot H2R3A6 189
type: UnificationXref
id: H2R3A6
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot A3KMS9 279
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF128
xref: uniprot H2RI77 297
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 177
organism: Monodelphis domestica

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot A0A1D5RHE7 334
organism: Macaca mulatta

uniprot Q5R1X1 90
type: UnificationXref
id: Q5R1X1
db: uniprot

Vesicle associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot F1PRG8 31
organism: Canis lupus familiaris

uniprot P63215 230
type: UnificationXref
id: P63215
db: uniprot

AGAP004940-PA
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot Q7PPI8 326
organism: Anopheles gambiae

G Protein s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot Q9HAV0 274
type: UnificationXref
id: Q9HAV0
db: uniprot

uniprot P18090 11
type: UnificationXref
id: P18090
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9ERB0 103
xref: PTHR19305:SF9
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 253
organism: Xenopus tropicalis

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P05132 303
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P05131 302
xref: PTHR24353:SF116
organism: Bos taurus

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 274
organism: Homo sapiens

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 350
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6T0T9 288
type: UnificationXref
id: F6T0T9
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 237
organism: Schizosaccharomyces pombe

G Protein s9 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(olf) subunit alpha
type: ProteinReference
xref: uniprot P38405 207
organism: Homo sapiens

uniprot Q5ZJ03 249
type: UnificationXref
id: Q5ZJ03
db: uniprot

uniprot Q29450 345
type: UnificationXref
id: Q29450
db: uniprot

Complex (GDP/G-Protein/_brBetasub_1)
type: Complex
component stoichiometry: GDP s5 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta1 s7 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s6 sa6 STOICHIOMETRY ID COMPLEX
component: G-Protein
component: GDP
component: Beta1
feature: COMPLEX BINDING FEATURE s35 a45 363
feature: COMPLEX BINDING FEATURE s35 a45 367
feature: COMPLEX BINDING FEATURE s35 a45 365
cellular location: cytosol

uniprot P62871 218
type: UnificationXref
id: P62871
db: uniprot

uniprot Q62442 93
type: UnificationXref
id: Q62442
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 137
organism: Canis lupus familiaris

uniprot O02495 56
type: UnificationXref
id: O02495
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 105

ncbitaxon 9615 29
type: UnificationXref
id: 9615
db: ncbitaxon

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 199
organism: Saccharomyces cerevisiae

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 258
organism: Danio rerio

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot E2RRA1 281
organism: Canis lupus familiaris

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

uniprot Q80SZ7 269
type: UnificationXref
id: Q80SZ7
db: uniprot

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 277
organism: Drosophila melanogaster

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

ncbitaxon 559292 65
type: UnificationXref
id: 559292
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 144
organism: Canis lupus familiaris

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 183
organism: Pan troglodytes

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P50150 210
type: UnificationXref
id: P50150
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 276
organism: Homo sapiens

Beta-1 adrenergic receptor
type: ProteinReference
xref: uniprot P08588 9
xref: PTHR24248:SF54
organism: Homo sapiens

uniprot F7ERP8 173
type: UnificationXref
id: F7ERP8
db: uniprot

uniprot G3V8K2 182
type: UnificationXref
id: G3V8K2
db: uniprot

uniprot Q3ZB92 323
type: UnificationXref
id: Q3ZB92
db: uniprot

ncbitaxon 9913 16
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot F6V461 154
type: UnificationXref
id: F6V461
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 92

uniprot F7G4Q0 290
type: UnificationXref
id: F7G4Q0
db: uniprot

uniprot F6VPY1 155
type: UnificationXref
id: F6VPY1
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot Q8MJ44 330
organism: Canis lupus familiaris

Descending adrenergic vagal neurons c1
type: CellularLocationVocabulary
comment: Descending adrenergic vagal neurons

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P13861 308
xref: PTHR11635:SF153
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot E9GNI4 285
organism: Daphnia pulex

uniprot P49177 209
type: UnificationXref
id: P49177
db: uniprot

G-Protein
type: ProteinReference
xref: P04436
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Beta1 adrenergic receptor signaling pathway.PROTEIN.GENERIC.G-Protein
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Uncharacterized protein
member entity reference: G-protein beta subunit
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: AGAP001506-PA
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide binding protein, beta 3
member entity reference: Guanine nucleotide-binding protein subunit beta-5b
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: G protein, Subunit Alpha
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide, olfactory type
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: G protein subunit beta 5
member entity reference: AGAP005913-PA
member entity reference: AGAP006521-PA
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: THO complex subunit, putative
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Gnb2 protein
member entity reference: G protein subunit alpha L
member entity reference: G protein subunit beta 2
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(olf) subunit alpha
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: G protein alpha s subunit
member entity reference: Gbeta5
member entity reference: AGAP005911-PA
member entity reference: Guanine nucleotide-binding protein subunit beta-5a
member entity reference: AGAP005912-PA
member entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

uniprot Q9WUF4 111
type: UnificationXref
id: Q9WUF4
db: uniprot

uniprot E2RHY4 136
type: UnificationXref
id: E2RHY4
db: uniprot

Syntaxin-3
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q08849 80
organism: Rattus norvegicus

uniprot Q7Q6D4 267
type: UnificationXref
id: Q7Q6D4
db: uniprot

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 115
organism: Pan troglodytes

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q17QQ3 84
xref: PTHR19305:SF5
organism: Bos taurus

uniprot H2Q2L5 5
type: UnificationXref
id: H2Q2L5
db: uniprot

uniprot F1LQT1 335
type: UnificationXref
id: F1LQT1
db: uniprot

uniprot P18851 199
type: UnificationXref
id: P18851
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot Q9N0Y0 106
organism: Macaca mulatta

Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide, olfactory type
type: ProteinReference
xref: uniprot F1RE11 145
organism: Danio rerio

NE s15 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NE
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q3T0Y8 87
xref: PTHR45701:SF7
organism: Bos taurus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P36975 67
xref: PTHR19305:SF14
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 161
organism: Monodelphis domestica

uniprot P05132 303
type: UnificationXref
id: P05132
db: uniprot

uniprot Q9GNR4 332
type: UnificationXref
id: Q9GNR4
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q15836 83
organism: Homo sapiens

uniprot P00515 300
type: UnificationXref
id: P00515
db: uniprot

uniprot A0A3Q1M3D6 116
type: UnificationXref
id: A0A3Q1M3D6
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa5 364
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P63026 75
type: UnificationXref
id: P63026
db: uniprot

uniprot Q6PH57 259
type: UnificationXref
id: Q6PH57
db: uniprot

PARTICIPANT STOICHIOMETRY re12 392
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 391
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q6PC54 96
organism: Danio rerio

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot O44419 58
xref: PTHR19305:SF14
organism: Strongylocentrotus purpuratus

uniprot P17343 198
type: UnificationXref
id: P17343
db: uniprot

uniprot P63045 78
type: UnificationXref
id: P63045
db: uniprot

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 255
organism: Danio rerio

uniprot F7BB02 165
type: UnificationXref
id: F7BB02
db: uniprot

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: G Protein s2 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s1 sa1 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-Protein
feature: ACTIVE 113
feature: COMPLEX BINDING FEATURE s17 a15 349
feature: COMPLEX BINDING FEATURE s17 a15 347
cellular location: cytosol

uniprot P81900 321
type: UnificationXref
id: P81900
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 153
organism: Macaca mulatta

NE
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa11 362
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q6PHV0 97
type: UnificationXref
id: Q6PHV0
db: uniprot

uniprot P33328 66
type: UnificationXref
id: P33328
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot P21137 311
type: UnificationXref
id: P21137
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q62442 93
xref: PTHR45701:SF1
organism: Mus musculus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 12

PARTICIPANT STOICHIOMETRY re18 386
type: Stoichiometry
physical entity: NE
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 387
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/_brBetasub_1)
stoichiometric coefficient: 1.0

uniprot E2RRA1 281
type: UnificationXref
id: E2RRA1
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot E1BW98 130
type: UnificationXref
id: E1BW98
db: uniprot

STATE_TRANSITION_LEFT__ER_type_Ca2_PLUS__channel-RIGHT__ER_type_Ca2_PLUS__channel-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 377
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 378
left: ER-type Ca2+ channel
interaction type: STATE_TRANSITION
right: ER-type Ca2+ channel

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 139

uniprot Q7T374 329
type: UnificationXref
id: Q7T374
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 226
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 225
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re18 388
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/_brBetasub_1/NE)
stoichiometric coefficient: 1.0

uniprot F6SSS3 152
type: UnificationXref
id: F6SSS3
db: uniprot

PARTICIPANT STOICHIOMETRY re20 384
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

ncbitaxon 6239 24
type: UnificationXref
id: 6239
db: ncbitaxon

LD03592p
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9W1I8 110
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re20 385
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

AC
type: Protein
entity reference: AC
feature: ACTIVE 113
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 216
organism: Rattus norvegicus

ncbitaxon 5664 284
type: UnificationXref
id: 5664
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 215
organism: Rattus norvegicus

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 104
organism: Arabidopsis thaliana

uniprot P00517 301
type: UnificationXref
id: P00517
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 170
organism: Ornithorhynchus anatinus

uniprot P22612 312
type: UnificationXref
id: P22612
db: uniprot

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q0V7N0 81
xref: PTHR45701:SF1
organism: Bos taurus

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F6V001 337
organism: Monodelphis domestica

uniprot P63219 234
type: UnificationXref
id: P63219
db: uniprot

ER-type Ca2+ channel
type: Protein
cellular location: sarcoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot Q9TT96 15
type: UnificationXref
id: Q9TT96
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 259
organism: Danio rerio

Adenylate cyclase
type: ProteinReference
xref: uniprot F1MJV4 336
xref: PTHR45627:SF6
organism: Bos taurus

AC
type: ProteinReference
xref: P04439
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Beta1 adrenergic receptor signaling pathway.PROTEIN.GENERIC.AC
comment: ENTITY_REFERENCE_NOTES=Long Name: AC Synonym: adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase Accession: P04439
member entity reference: Adenylate cyclase
member entity reference: Adenylate cyclase type 7
member entity reference: Adenylate cyclase type 2

uniprot O60262 195
type: UnificationXref
id: O60262
db: uniprot

uniprot F1NLV4 143
type: UnificationXref
id: F1NLV4
db: uniprot

uniprot F6PV18 150
type: UnificationXref
id: F6PV18
db: uniprot

ncbitaxon 9544 18
type: UnificationXref
id: 9544
db: ncbitaxon

NE
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7EBQ5 289
type: UnificationXref
id: F7EBQ5
db: uniprot

ACTIVE 113
type: EntityFeature
comment: Active state

uniprot P30671 204
type: UnificationXref
id: P30671
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 141

uniprot P27791 314
type: UnificationXref
id: P27791
db: uniprot

uniprot P52287 214
type: UnificationXref
id: P52287
db: uniprot

ncbitaxon 13616 35
type: UnificationXref
id: 13616
db: ncbitaxon

PTHR19957:SF34
type: RelationshipXref
id: PTHR19957:SF34
db: PANTHER Family
relationship type: By Homology

ER-type Ca2+ channel
type: Protein
feature: ACTIVE 113
cellular location: sarcoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QIS2 19
xref: PTHR45701:SF7
organism: Macaca mulatta

ncbitaxon 7955 92
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot O14775 194
type: UnificationXref
id: O14775
db: uniprot

SNARE COMPLEX
type: ProteinReference
xref: P04435
standard name: SNARE Complex
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: SNARE COMPLEX Synonym: Synonym not specified Accession: P04435
comment: ENTITY_REFERENCE_ID_DESC=Beta1 adrenergic receptor signaling pathway.PROTEIN.GENERIC.SNARE COMPLEX
member entity reference: Synaptobrevin homolog 1
member entity reference: Vesicle associated membrane protein 8
member entity reference: Synaptosomal-associated protein 29
member entity reference: Putative synaptobrevin homologue SNC1/2 (Eurofung)
member entity reference: Uncharacterized protein
member entity reference: Synaptosomal-associated protein 25
member entity reference: VAMP2 isoform 3
member entity reference: Synaptosomal-associated protein
member entity reference: Synaptobrevin homolog 2
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Syntaxin 3
member entity reference: Synaptobrevin-1
member entity reference: Synaptobrevin
member entity reference: SNAP29 isoform 1
member entity reference: Vesicle-associated membrane protein 2
member entity reference: Syntaxin-3
member entity reference: t-SNARE protein aex-4
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: Neuronal synaptobrevin, isoform J
member entity reference: Vesicle-associated membrane protein 8 (Endobrevin)
member entity reference: Synaptosomal-associated protein 25-B
member entity reference: Syntaxin 3A
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Soluble NSF attachment protein 29
member entity reference: Putative SNAP25 homologous protein SNAP30
member entity reference: Vesicle associated membrane protein 1
member entity reference: Synaptosomal-associated protein 23
member entity reference: VAMP3 isoform 1
member entity reference: SNAP25 homologous protein SNAP33
member entity reference: Synaptosomal-associated protein 25-A

uniprot K7E376 192
type: UnificationXref
id: K7E376
db: uniprot

uniprot F1PRG8 31
type: UnificationXref
id: F1PRG8
db: uniprot

uniprot P12369 306
type: UnificationXref
id: P12369
db: uniprot

NE
type: SmallMolecule
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P34099 317
xref: PTHR24353:SF37
organism: Dictyostelium discoideum

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot P18489 62
type: UnificationXref
id: P18489
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot H2Q995 50
xref: PTHR19305:SF4
organism: Pan troglodytes

cAMP-dependent protein kinase catalytic subunit 3
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot P16912 309
organism: Drosophila melanogaster

uniprot O14610 193
type: UnificationXref
id: O14610
db: uniprot

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 171
organism: Xenopus tropicalis

uniprot K7AE17 191
type: UnificationXref
id: K7AE17
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 154
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 197
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 217
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EJA3 172
xref: PTHR10218:SF320
organism: Ornithorhynchus anatinus

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 89

uniprot Q9S7P9 107
type: UnificationXref
id: Q9S7P9
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 257
organism: Danio rerio

uniprot M9PE71 53
type: UnificationXref
id: M9PE71
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 254
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: uniprot Q3ZB92 323
xref: PTHR24353:SF116
organism: Danio rerio

uniprot Q7PXF7 327
type: UnificationXref
id: Q7PXF7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 190
organism: Canis lupus familiaris

uniprot E9GNI4 285
type: UnificationXref
id: E9GNI4
db: uniprot

Protein kinase A catalytic subunit isoform 1
type: ProteinReference
xref: uniprot Q9GNR4 332
xref: PTHR24353:SF67
organism: Leishmania major

uniprot F7F580 175
type: UnificationXref
id: F7F580
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot A0A2I3SR99 21
organism: Pan troglodytes

uniprot P59768 217
type: UnificationXref
id: P59768
db: uniprot

uniprot P31324 316
type: UnificationXref
id: P31324
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot A0A1D5QYR9 20
organism: Macaca mulatta

uniprot F6XHP0 157
type: UnificationXref
id: F6XHP0
db: uniprot

ncbitaxon 7227 54
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot Q0V7N0 81
type: UnificationXref
id: Q0V7N0
db: uniprot

uniprot F6XVE6 158
type: UnificationXref
id: F6XVE6
db: uniprot

GDP s76 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re12
control type: ACTIVATION
controller: Ca2+ channel

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 176
organism: Macaca mulatta

uniprot B7Q3T6 124
type: UnificationXref
id: B7Q3T6
db: uniprot

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 202
organism: Mus musculus

uniprot F6VUT7 40
type: UnificationXref
id: F6VUT7
db: uniprot

uniprot E2RRD1 282
type: UnificationXref
id: E2RRD1
db: uniprot

uniprot Q7Q3T7 328
type: UnificationXref
id: Q7Q3T7
db: uniprot

uniprot A0A2I3SR99 21
type: UnificationXref
id: A0A2I3SR99
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa6 366
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H9EQQ4 298
type: UnificationXref
id: H9EQQ4
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F5HMS4 32
xref: PTHR19305:SF14
organism: Anopheles gambiae

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 188
organism: Pan troglodytes

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 245
organism: Danio rerio

uniprot Q922R0 331
type: UnificationXref
id: Q922R0
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 65

uniprot K7AEL3 299
type: UnificationXref
id: K7AEL3
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 54

uniprot Q5KI86 246
type: UnificationXref
id: Q5KI86
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H2Q3R5 49
xref: PTHR19957:SF34
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 250
organism: Mus musculus

GTP s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot F7A943 45
type: UnificationXref
id: F7A943
db: uniprot

PTHR10218:SF212
type: RelationshipXref
id: PTHR10218:SF212
db: PANTHER Family
relationship type: By Homology

uniprot Q27687 322
type: UnificationXref
id: Q27687
db: uniprot

uniprot F7ASR8 164
type: UnificationXref
id: F7ASR8
db: uniprot

uniprot Q15836 83
type: UnificationXref
id: Q15836
db: uniprot

uniprot P31109 64
type: UnificationXref
id: P31109
db: uniprot

uniprot A7EDU2 122
type: UnificationXref
id: A7EDU2
db: uniprot

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 263
organism: Anopheles gambiae

ncbitaxon 10116 12
type: UnificationXref
id: 10116
db: ncbitaxon

SNARE COMPLEX
type: Protein
entity reference: SNARE COMPLEX
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot F7ES96 174
type: UnificationXref
id: F7ES96
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 251
organism: Mus musculus

uniprot Q7ZUC1 99
type: UnificationXref
id: Q7ZUC1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 252
organism: Mus musculus

uniprot P05131 302
type: UnificationXref
id: P05131
db: uniprot

uniprot Q90Z40 271
type: UnificationXref
id: Q90Z40
db: uniprot

uniprot P63216 231
type: UnificationXref
id: P63216
db: uniprot

ncbitaxon 665079 123
type: UnificationXref
id: 665079
db: ncbitaxon

G protein subunit alpha L
type: ProteinReference
xref: uniprot A0A2I3SJ53 114
organism: Pan troglodytes

uniprot Q08462 344
type: UnificationXref
id: Q08462
db: uniprot

uniprot E2R907 30
type: UnificationXref
id: E2R907
db: uniprot

uniprot P54313 216
type: UnificationXref
id: P54313
db: uniprot

Synaptosomal-associated protein 29
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9Z2P6 112
organism: Rattus norvegicus

uniprot Q05337 235
type: UnificationXref
id: Q05337
db: uniprot

uniprot P12370 307
type: UnificationXref
id: P12370
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q9WUF4 111
organism: Rattus norvegicus

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot Q5R1X1 90
organism: Pan troglodytes

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 4

uniprot Q8MJ44 330
type: UnificationXref
id: Q8MJ44
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 37

uniprot P62874 221
type: UnificationXref
id: P62874
db: uniprot

uniprot F6XYX9 42
type: UnificationXref
id: F6XYX9
db: uniprot

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: uniprot Q922R0 331
xref: PTHR24353:SF37
organism: Mus musculus

Complex (Beta1/NE)
type: Complex
component stoichiometry: Beta1 s12 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: NE s15 sa13 STOICHIOMETRY ID COMPLEX
component: NE
component: Beta1
feature: COMPLEX BINDING FEATURE s39 a54 351
feature: COMPLEX BINDING FEATURE s39 a54 353
cellular location: cytosol

TRIGGER
type: RelationshipTypeVocabulary

uniprot F7CTP1 168
type: UnificationXref
id: F7CTP1
db: uniprot

uniprot Q08849 80
type: UnificationXref
id: Q08849
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 193
organism: Homo sapiens

uniprot Q0VFC4 236
type: UnificationXref
id: Q0VFC4
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 113
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 209
organism: Arabidopsis thaliana

uniprot F6ZDB2 162
type: UnificationXref
id: F6ZDB2
db: uniprot

uniprot F6Y3N2 160
type: UnificationXref
id: F6Y3N2
db: uniprot

uniprot F6UBJ8 36
type: UnificationXref
id: F6UBJ8
db: uniprot

uniprot P36975 67
type: UnificationXref
id: P36975
db: uniprot

uniprot A0A3Q1NGS8 117
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

uniprot F7G3J2 177
type: UnificationXref
id: F7G3J2
db: uniprot

uniprot Q80TL1 346
type: UnificationXref
id: Q80TL1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 196
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot F7H6T2 291
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 180
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CB49 166
organism: Monodelphis domestica

Ca2+ channel
type: Protein
feature: ACTIVE 113
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
type: ProteinReference
xref: uniprot Q6R0H7 260
xref: PTHR10218:SF320
organism: Mus musculus

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot E2QUL2 28
xref: PTHR45701:SF7
organism: Canis lupus familiaris

ncbitaxon 44689 206
type: UnificationXref
id: 44689
db: ncbitaxon

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 147
organism: Neurospora crassa

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 208
organism: Rattus norvegicus

Protein kinase, X-linked
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q5BK52 324
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 120
organism: Xenopus tropicalis

uniprot P68181 319
type: UnificationXref
id: P68181
db: uniprot

uniprot Q17QQ3 84
type: UnificationXref
id: Q17QQ3
db: uniprot

uniprot P13861 308
type: UnificationXref
id: P13861
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q28024 240
organism: Bos taurus

uniprot K7ADQ0 340
type: UnificationXref
id: K7ADQ0
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 159
organism: Monodelphis domestica

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 100
organism: Schizosaccharomyces pombe

uniprot E1C795 131
type: UnificationXref
id: E1C795
db: uniprot

uniprot F6ZIZ9 163
type: UnificationXref
id: F6ZIZ9
db: uniprot

uniprot P63024 73
type: UnificationXref
id: P63024
db: uniprot

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 267
organism: Anopheles gambiae

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 265
organism: Anopheles gambiae

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 266
organism: Anopheles gambiae

Bos taurus
type: BioSource
xref: ncbitaxon 9913 16

uniprot P12368 305
type: UnificationXref
id: P12368
db: uniprot

uniprot E9AFM1 283
type: UnificationXref
id: E9AFM1
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 41

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 185
organism: Pan troglodytes

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q6PC54 96
type: UnificationXref
id: Q6PC54
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 241
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 204
organism: Bos taurus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31324 316
organism: Mus musculus

uniprot F7CFG8 167
type: UnificationXref
id: F7CFG8
db: uniprot

G protein alpha s subunit
type: ProteinReference
xref: PTHR10218:SF212
xref: uniprot P20354 200
organism: Drosophila melanogaster

NE s11 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NE
stoichiometric coefficient: 1.0

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 125

uniprot P31323 315
type: UnificationXref
id: P31323
db: uniprot

AGAP008039-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q3T7 328
xref: PTHR24353:SF117
organism: Anopheles gambiae

uniprot E2RJB3 137
type: UnificationXref
id: E2RJB3
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 140
organism: Dictyostelium purpureum

uniprot P51828 342
type: UnificationXref
id: P51828
db: uniprot

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P12370 307
organism: Drosophila melanogaster

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re20
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 384
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 385
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 29

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 117
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 187
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 178
organism: Ornithorhynchus anatinus

uniprot Q63666 94
type: UnificationXref
id: Q63666
db: uniprot

uniprot F5HMS4 32
type: UnificationXref
id: F5HMS4
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q80TL1 346
organism: Mus musculus

VAMP3 isoform 1
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot G2HIJ9 47
organism: Pan troglodytes

uniprot P63213 228
type: UnificationXref
id: P63213
db: uniprot

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

uniprot H2Q995 50
type: UnificationXref
id: H2Q995
db: uniprot

uniprot Q9VH76 109
type: UnificationXref
id: Q9VH76
db: uniprot

uniprot P63217 232
type: UnificationXref
id: P63217
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31323 315
organism: Homo sapiens

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot E2R907 30
organism: Canis lupus familiaris

ncbitaxon 9258 41
type: UnificationXref
id: 9258
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 167
organism: Monodelphis domestica

uniprot H2Q3R5 49
type: UnificationXref
id: H2Q3R5
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 70

uniprot Q8CGK7 270
type: UnificationXref
id: Q8CGK7
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P12369 306
organism: Rattus norvegicus

uniprot F6UFJ7 38
type: UnificationXref
id: F6UFJ7
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P12367 304
xref: PTHR11635:SF153
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12368 305
organism: Rattus norvegicus

uniprot E2R2S8 133
type: UnificationXref
id: E2R2S8
db: uniprot

PARTICIPANT STOICHIOMETRY re2 376
type: Stoichiometry
physical entity: NE
stoichiometric coefficient: 1.0

uniprot Q803H5 268
type: UnificationXref
id: Q803H5
db: uniprot

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51828 342
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 179
organism: Monodelphis domestica

uniprot F7H6T2 291
type: UnificationXref
id: F7H6T2
db: uniprot

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot P51829 343
xref: PTHR45627:SF9
organism: Mus musculus

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 107
organism: Arabidopsis thaliana

uniprot F2Z3T8 146
type: UnificationXref
id: F2Z3T8
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot Q9VH76 109
organism: Drosophila melanogaster

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

PARTICIPANT STOICHIOMETRY re2 375
type: Stoichiometry
physical entity: NE
stoichiometric coefficient: 1.0

uniprot H2QLA1 51
type: UnificationXref
id: H2QLA1
db: uniprot

uniprot A8X8S6 26
type: UnificationXref
id: A8X8S6
db: uniprot

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 256
organism: Danio rerio

uniprot A5PEW5 23
type: UnificationXref
id: A5PEW5
db: uniprot

uniprot F7EJA3 172
type: UnificationXref
id: F7EJA3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 246
organism: Cryptococcus neoformans

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 138
organism: Daphnia pulex

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 389
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 390
left: AC
interaction type: STATE_TRANSITION
right: AC

uniprot C3ZSF0 126
type: UnificationXref
id: C3ZSF0
db: uniprot

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: uniprot P51817 318
xref: PTHR24353:SF133
organism: Homo sapiens

ncbitaxon 7739 127
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot P60880 72
type: UnificationXref
id: P60880
db: uniprot

G protein, Subunit Alpha
type: ProteinReference
xref: uniprot Q7KPV0 262
organism: Caenorhabditis elegans

cAMP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 275
organism: Homo sapiens

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot Q29450 345
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re22 378
type: Stoichiometry
physical entity: ER-type Ca2+ channel
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 151
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re22 377
type: Stoichiometry
physical entity: ER-type Ca2+ channel
stoichiometric coefficient: 1.0

uniprot Q10282 237
type: UnificationXref
id: Q10282
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 160
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 124
organism: Ixodes scapularis

uniprot Q61016 251
type: UnificationXref
id: Q61016
db: uniprot

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot P22612 312
organism: Homo sapiens

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot P81900 321
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 157
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re9
controller: AC

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 273
organism: Mus musculus

uniprot P26769 341
type: UnificationXref
id: P26769
db: uniprot

uniprot P60877 68
type: UnificationXref
id: P60877
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 164
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 201
organism: Drosophila melanogaster

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot F6Q9S4 287
xref: PTHR11635:SF156
organism: Bos taurus

TRIGGER
type: Control
xref: TRIGGER
controlled: muscle contraction
controller: Ca2+

TRIGGER
type: Control
xref: TRIGGER
controlled: muscle contraction
controller: Ca2+

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 169
organism: Monodelphis domestica

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 244
organism: Emericella nidulans

uniprot P54311 215
type: UnificationXref
id: P54311
db: uniprot

ncbitaxon 9031 70
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot P38405 207
type: UnificationXref
id: P38405
db: uniprot

PARTICIPANT STOICHIOMETRY re11 369
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H2QFK0 293
organism: Pan troglodytes

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6VM87 39
xref: PTHR19305:SF5
organism: Monodelphis domestica

uniprot Q28H40 241
type: UnificationXref
id: Q28H40
db: uniprot

uniprot P63027 76
type: UnificationXref
id: P63027
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 33

uniprot F6Q9S4 287
type: UnificationXref
id: F6Q9S4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 142
organism: Bos taurus

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot H2RER5 296
organism: Pan troglodytes

uniprot Q7KPV0 262
type: UnificationXref
id: Q7KPV0
db: uniprot

uniprot Q9Z2P6 112
type: UnificationXref
id: Q9Z2P6
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot P26769 341
organism: Rattus norvegicus

Synaptosomal-associated protein 23
type: ProteinReference
xref: uniprot O09044 57
xref: PTHR19305:SF4
organism: Mus musculus

PTHR24353:SF67
type: RelationshipXref
id: PTHR24353:SF67
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 165
organism: Macaca mulatta

uniprot P63044 77
type: UnificationXref
id: P63044
db: uniprot

uniprot F7HAK5 292
type: UnificationXref
id: F7HAK5
db: uniprot

PARTICIPANT STOICHIOMETRY re11 370
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 268
organism: Danio rerio

TRANSPORT_LEFT__NE-RIGHT__NE-_re2
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 375
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 376
left: NE
interaction type: TRANSPORT
right: NE

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A8X8S6 26
organism: Caenorhabditis briggsae

ncbitaxon 6945 125
type: UnificationXref
id: 6945
db: ncbitaxon

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q63666 94
xref: PTHR45701:SF1
organism: Rattus norvegicus

uniprot Q6P025 256
type: UnificationXref
id: Q6P025
db: uniprot

uniprot Q5ASG1 88
type: UnificationXref
id: Q5ASG1
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q7SZZ5 98
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 242
organism: Rattus norvegicus

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 136
organism: Canis lupus familiaris

uniprot F6TFY2 153
type: UnificationXref
id: F6TFY2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 195
organism: Homo sapiens

uniprot Q28024 240
type: UnificationXref
id: Q28024
db: uniprot

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

uniprot P43425 208
type: UnificationXref
id: P43425
db: uniprot

ncbitaxon 7668 59
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot P26308 201
type: UnificationXref
id: P26308
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 128
organism: Rattus norvegicus

GO GO:0008021 4
type: UnificationXref
id: GO:0008021
db: GO

uniprot Q92356 100
type: UnificationXref
id: Q92356
db: uniprot

uniprot Q9UK08 276
type: UnificationXref
id: Q9UK08
db: uniprot

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 101

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

uniprot P62872 219
type: UnificationXref
id: P62872
db: uniprot

uniprot F1A421 140
type: UnificationXref
id: F1A421
db: uniprot

uniprot P34099 317
type: UnificationXref
id: P34099
db: uniprot

uniprot P51829 343
type: UnificationXref
id: P51829
db: uniprot

uniprot P63212 227
type: UnificationXref
id: P63212
db: uniprot

uniprot Q9W1I8 110
type: UnificationXref
id: Q9W1I8
db: uniprot

uniprot F1MYW8 142
type: UnificationXref
id: F1MYW8
db: uniprot

uniprot E2QUL2 28
type: UnificationXref
id: E2QUL2
db: uniprot

uniprot O95721 61
type: UnificationXref
id: O95721
db: uniprot

uniprot P63078 226
type: UnificationXref
id: P63078
db: uniprot

uniprot G2HIJ9 47
type: UnificationXref
id: G2HIJ9
db: uniprot

ncbitaxon 5786 141
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot F6YZA3 161
type: UnificationXref
id: F6YZA3
db: uniprot

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

uniprot F1MJV4 336
type: UnificationXref
id: F1MJV4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 236
organism: Xenopus tropicalis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 261
organism: Danio rerio

uniprot Q6DH55 255
type: UnificationXref
id: Q6DH55
db: uniprot

AC
type: Protein
entity reference: AC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5QYR9 20
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

uniprot Q6DBV8 325
type: UnificationXref
id: Q6DBV8
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 239
organism: Caenorhabditis elegans

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 121
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 10

uniprot P62879 222
type: UnificationXref
id: P62879
db: uniprot

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

uniprot F7GI54 179
type: UnificationXref
id: F7GI54
db: uniprot

uniprot P17612 310
type: UnificationXref
id: P17612
db: uniprot

uniprot Q3SZ98 243
type: UnificationXref
id: Q3SZ98
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q28HP6 85
xref: PTHR19305:SF5
organism: Xenopus tropicalis

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H9EQQ4 298
organism: Macaca mulatta

uniprot E2RGI5 135
type: UnificationXref
id: E2RGI5
db: uniprot

ncbitaxon 7165 33
type: UnificationXref
id: 7165
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot F7HAK5 292
organism: Macaca mulatta

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 59

uniprot P68182 320
type: UnificationXref
id: P68182
db: uniprot

uniprot Q28HP6 85
type: UnificationXref
id: Q28HP6
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P22694 313
xref: PTHR24353:SF116
organism: Homo sapiens

uniprot H2Q9G5 186
type: UnificationXref
id: H2Q9G5
db: uniprot

uniprot H2QXB9 294
type: UnificationXref
id: H2QXB9
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 131
organism: Gallus gallus

uniprot H2Q1D9 184
type: UnificationXref
id: H2Q1D9
db: uniprot

uniprot Q7SZZ5 98
type: UnificationXref
id: Q7SZZ5
db: uniprot

uniprot W4YRI6 333
type: UnificationXref
id: W4YRI6
db: uniprot

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 373
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 374
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

PRKAR2A isoform 1
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot K7AEL3 299
organism: Pan troglodytes

uniprot P20354 200
type: UnificationXref
id: P20354
db: uniprot

uniprot P63218 233
type: UnificationXref
id: P63218
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 278
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 174
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 143
organism: Gallus gallus

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 64
organism: Saccharomyces cerevisiae

uniprot F7G7I9 178
type: UnificationXref
id: F7G7I9
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 182
organism: Rattus norvegicus

AGAP001384-PA
type: ProteinReference
xref: uniprot Q7PXF7 327
xref: PTHR24353:SF117
organism: Anopheles gambiae

PKA
type: Protein
entity reference: PKA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re9 374
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 373
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot P50153 212
type: UnificationXref
id: P50153
db: uniprot

Guanine nucleotide-binding protein G(f) subunit alpha
type: ProteinReference
xref: uniprot Q05337 235
organism: Drosophila melanogaster

uniprot F1RE11 145
type: UnificationXref
id: F1RE11
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 122
organism: Sclerotinia sclerotiorum

uniprot A4IFL6 119
type: UnificationXref
id: A4IFL6
db: uniprot

uniprot P83351 79
type: UnificationXref
id: P83351
db: uniprot

SNAP29 isoform 1
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot H2QLA1 51
organism: Pan troglodytes

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 348
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR45627:SF9
type: RelationshipXref
id: PTHR45627:SF9
db: PANTHER Family
relationship type: By Homology

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 206

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 146
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot H2RCB8 52
type: UnificationXref
id: H2RCB8
db: uniprot

PANTHER Pathway P04377 1
type: UnificationXref
id: P04377
db: PANTHER Pathway

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 25

uniprot P23763 63
type: UnificationXref
id: P23763
db: uniprot

uniprot E1BS74 129
type: UnificationXref
id: E1BS74
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 192
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 269
organism: Mus musculus

uniprot F6Q503 286
type: UnificationXref
id: F6Q503
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 271
organism: Danio rerio

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__ER_type_Ca2_PLUS__channel-RIGHT__ER_type_Ca2_PLUS__channel-_re22
control type: ACTIVATION
controller: PKA

uniprot A0A2I3SJ53 114
type: UnificationXref
id: A0A2I3SJ53
db: uniprot

uniprot Q6PBR4 257
type: UnificationXref
id: Q6PBR4
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 163
organism: Macaca mulatta

uniprot F7EPG4 46
type: UnificationXref
id: F7EPG4
db: uniprot

Beta1
type: Protein
entity reference: Beta1
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa12 352
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 48
organism: Caenorhabditis elegans

Protein kinase A catalytic subunit isoform 2
type: ProteinReference
xref: uniprot E9AFM1 283
xref: PTHR24353:SF67
organism: Leishmania major

STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 370
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 369
left: Ca2+ channel
interaction type: STATE_TRANSITION
right: Ca2+ channel

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot P23763 63
xref: PTHR45701:SF1
organism: Homo sapiens

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 189
organism: Pan troglodytes

Ca2+
type: SmallMolecule
cellular location: sarcoplasmic reticulum
comment: SPECIES_TYPE=ION

uniprot Q20636 239
type: UnificationXref
id: Q20636
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot F6ZAV4 338
xref: PTHR45627:SF6
organism: Ornithorhynchus anatinus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re10
controller: cAMP

uniprot J9P702 190
type: UnificationXref
id: J9P702
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

GDP s5 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

TRANSPORT
type: InteractionVocabulary

eco ECO:0000305 25
type: UnificationXref
id: ECO:0000305
db: eco

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s76 sa8 356
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Beta-1 adrenergic receptor
type: ProteinReference
xref: PTHR24248:SF54
xref: uniprot P34971 13
organism: Mus musculus

uniprot Q61011 250
type: UnificationXref
id: Q61011
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot F7G4Q0 290
organism: Monodelphis domestica

PRKACG isoform 1
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot H2QXB9 294
organism: Pan troglodytes

GO GO:0016529 3
type: UnificationXref
id: GO:0016529
db: GO

uniprot Q7PPI8 326
type: UnificationXref
id: Q7PPI8
db: uniprot

uniprot F6V001 337
type: UnificationXref
id: F6V001
db: uniprot

uniprot H2QFK0 293
type: UnificationXref
id: H2QFK0
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F7DL70 339
organism: Macaca mulatta

uniprot F7H6T7 180
type: UnificationXref
id: F7H6T7
db: uniprot

uniprot G5EEN8 48
type: UnificationXref
id: G5EEN8
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 284

uniprot P16912 309
type: UnificationXref
id: P16912
db: uniprot

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

uniprot P63077 225
type: UnificationXref
id: P63077
db: uniprot

uniprot P63025 74
type: UnificationXref
id: P63025
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF320
xref: uniprot F6ZDB2 162
organism: Monodelphis domestica

Beta1 adrenergic receptor signaling pathway
type: Pathway
pathway component: PHYSICAL_STIMULATION
pathway component: TRIGGER
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re17
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re10
pathway component: STATE_TRANSITION_LEFT__ER_type_Ca2_PLUS__channel-RIGHT__ER_type_Ca2_PLUS__channel-_re22
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re9
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re20
pathway component: TRANSPORT_LEFT__NE-RIGHT__NE-_re2
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re11
pathway component: HETERODIMER_ASSOCIATION_LEFT__NE-_Complex__GDP_G_Protein__brBetasub_1_-RIGHT__Complex__GDP_G_Protein__brBetasub_1_NE_-_re18
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re12
pathway component: DISSOCIATION_LEFT__GTP-_Complex__GDP_G_Protein__brBetasub_1_NE_-RIGHT__Complex__Beta1_NE_-_GDP-_Complex__GTP_G_Protein_-_re19
xref: PANTHER Pathway P04377 1
comment: MODEL_NOTES=Panther Pathway: P04377 No pathway definition

PARTICIPANT STOICHIOMETRY re10 372
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 371
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Beta1 s12 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta1
stoichiometric coefficient: 1.0

Syntaxin 3A
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q6PHV0 97
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 173
organism: Ornithorhynchus anatinus

uniprot F6VM87 39
type: UnificationXref
id: F6VM87
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 155
organism: Ornithorhynchus anatinus

Syntaxin 3
type: ProteinReference
xref: uniprot F7EPG4 46
xref: PTHR19957:SF34
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 205
organism: Dictyostelium discoideum

ncbitaxon 6669 139
type: UnificationXref
id: 6669
db: ncbitaxon

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: uniprot F7EBQ5 289
xref: PTHR24353:SF116
organism: Macaca mulatta