uniprot P54311 131
type: UnificationXref
id: P54311
db: uniprot

uniprot F7BB02 77
type: UnificationXref
id: F7BB02
db: uniprot

Beta2
type: Protein
entity reference: Beta2
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa5 281
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9598 6
type: UnificationXref
id: 9598
db: ncbitaxon

salbutamol (Ventolin)
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7CFG8 79
type: UnificationXref
id: F7CFG8
db: uniprot

uniprot P62880 139
type: UnificationXref
id: P62880
db: uniprot

Beta-2 adrenergic receptor
type: ProteinReference
xref: uniprot P07550 9
xref: PTHR24248:SF21
organism: Homo sapiens

uniprot A8XW88 199
type: UnificationXref
id: A8XW88
db: uniprot

uniprot E2R2S8 43
type: UnificationXref
id: E2R2S8
db: uniprot

uniprot P18762 13
type: UnificationXref
id: P18762
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 167
organism: Gallus gallus

Beta-2 adrenergic receptor
type: ProteinReference
xref: uniprot P10608 11
xref: PTHR24248:SF21
organism: Rattus norvegicus

uniprot A4IFL6 26
type: UnificationXref
id: A4IFL6
db: uniprot

ncbitaxon 6239 111
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q5BH99 161
type: UnificationXref
id: Q5BH99
db: uniprot

uniprot P51829 264
type: UnificationXref
id: P51829
db: uniprot

uniprot P63219 150
type: UnificationXref
id: P63219
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 26
organism: Bos taurus

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q08462 265
xref: PTHR45627:SF6
organism: Homo sapiens

Complex (GDP/G-Protein/_brBetasub_1)
type: Complex
component stoichiometry: GDP s3 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s4 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta2 s5 sa5 STOICHIOMETRY ID COMPLEX
component: GDP
component: Beta2
component: G-Protein
feature: COMPLEX BINDING FEATURE s35 a45 280
feature: COMPLEX BINDING FEATURE s35 a45 278
feature: COMPLEX BINDING FEATURE s35 a45 276
cellular location: cytosol

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 88
organism: Macaca mulatta

ncbitaxon 5664 204
type: UnificationXref
id: 5664
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 143
organism: Bos taurus

By Homology
type: RelationshipTypeVocabulary

AC
type: ProteinReference
xref: P04446
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Beta2 adrenergic receptor signaling pathway.PROTEIN.GENERIC.AC
comment: ENTITY_REFERENCE_NOTES=Long Name: AC Synonym: adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase Accession: P04446
member entity reference: Adenylate cyclase type 7
member entity reference: Adenylate cyclase
member entity reference: Adenylate cyclase type 2

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 117
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 14

PRKACB isoform 3
type: ProteinReference
xref: uniprot H2R1G3 215
xref: PTHR24353:SF116
organism: Pan troglodytes

uniprot P62881 140
type: UnificationXref
id: P62881
db: uniprot

uniprot P31323 235
type: UnificationXref
id: P31323
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 100
organism: Pan troglodytes

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 163
organism: Danio rerio

ncbitaxon 6669 49
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot P22694 233
type: UnificationXref
id: P22694
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 113

uniprot F7EJA3 84
type: UnificationXref
id: F7EJA3
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 115

uniprot F6T0T9 208
type: UnificationXref
id: F6T0T9
db: uniprot

uniprot P59768 133
type: UnificationXref
id: P59768
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 168
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 230
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 138
organism: Homo sapiens

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 311
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 310
left: AC
interaction type: STATE_TRANSITION
right: AC

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 137
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 135
organism: Canis lupus familiaris

uniprot P63078 142
type: UnificationXref
id: P63078
db: uniprot

uniprot P54313 132
type: UnificationXref
id: P54313
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 136
organism: Homo sapiens

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 140
organism: Mus musculus

uniprot P63214 145
type: UnificationXref
id: P63214
db: uniprot

Relaxation of Bronchial Air Passage
type: Pathway

PTHR10218:SF212
type: RelationshipXref
id: PTHR10218:SF212
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 139
organism: Mus musculus

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F6T0T9 208
organism: Xenopus tropicalis

uniprot Q27687 242
type: UnificationXref
id: Q27687
db: uniprot

uniprot P17612 230
type: UnificationXref
id: P17612
db: uniprot

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

uniprot B7Q3T6 32
type: UnificationXref
id: B7Q3T6
db: uniprot

uniprot F7GI54 91
type: UnificationXref
id: F7GI54
db: uniprot

uniprot P81900 241
type: UnificationXref
id: P81900
db: uniprot

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 181
organism: Anopheles gambiae

Epinephrine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa9 289
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 58

uniprot A0A2I3TUD1 21
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

uniprot Q15KE4 155
type: UnificationXref
id: Q15KE4
db: uniprot

uniprot E2RJB3 47
type: UnificationXref
id: E2RJB3
db: uniprot

uniprot P43425 123
type: UnificationXref
id: P43425
db: uniprot

PTHR10218:SF320
type: RelationshipXref
id: PTHR10218:SF320
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 134
organism: Bos taurus

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: GTP s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s2 sa2 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-Protein
feature: COMPLEX BINDING FEATURE s17 a15 274
feature: COMPLEX BINDING FEATURE s17 a15 272
feature: ACTIVE 19
cellular location: cytosol

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F1LQT1 256
organism: Rattus norvegicus

Epinephrine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 169
organism: Mus musculus

Beta2 s5 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta2
stoichiometric coefficient: 1.0

G Protein s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 170
organism: Mus musculus

DISSOCIATION_LEFT__GTP-_Complex__GDP_G_Protein__brBetasub_2_Epinephrine_-RIGHT__Complex__GTP_G_Protein_-_Complex__Beta2_Epinephrine_-_GDP-_re25
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 299
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 297
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 300
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 298
left: Complex (GDP/G-Protein/_brBetasub_2/Epinephrine)
left: GTP
interaction type: DISSOCIATION
right: GDP
right: Complex (GTP/G-Protein)
right: Complex (Beta2/Epinephrine)

ACTIVE 19
type: EntityFeature
comment: Active state

uniprot F6XHP0 69
type: UnificationXref
id: F6XHP0
db: uniprot

uniprot Q5BK52 244
type: UnificationXref
id: Q5BK52
db: uniprot

G protein subunit alpha L
type: ProteinReference
xref: uniprot A0A2I3SJ53 20
organism: Pan troglodytes

ncbitaxon 559292 113
type: UnificationXref
id: 559292
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 80
organism: Macaca mulatta

uniprot Q803H5 187
type: UnificationXref
id: Q803H5
db: uniprot

ncbitaxon 665079 31
type: UnificationXref
id: 665079
db: ncbitaxon

PKA
type: ProteinReference
xref: P04444
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Beta2 adrenergic receptor signaling pathway.PROTEIN.GENERIC.PKA
comment: ENTITY_REFERENCE_NOTES=Long Name: PKA Synonym: protein kinase A Accession: P04444
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: Protein kinase, X-linked
member entity reference: Uncharacterized protein
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: cAMP-dependent protein kinase catalytic subunit 3
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta a
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: AGAP004940-PA
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: Protein kinase A catalytic subunit
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: AGAP008039-PA (Fragment)
member entity reference: cAMP-dependent protein kinase catalytic subunit PRKX
member entity reference: PRKACB isoform 3
member entity reference: AGAP001384-PA
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: Protein kinase A catalytic subunit isoform 1
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1
member entity reference: Protein kinase A catalytic subunit isoform 2
member entity reference: PRKACG isoform 1
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: PRKAR2A isoform 1
member entity reference: Protein kinase cAMP-activated catalytic subunit beta

uniprot Q20636 156
type: UnificationXref
id: Q20636
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re17
controller: Complex (GTP/G-Protein)

uniprot K7AEL3 219
type: UnificationXref
id: K7AEL3
db: uniprot

uniprot F6YZA3 73
type: UnificationXref
id: F6YZA3
db: uniprot

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 166
organism: Xenopus tropicalis

synaptic vesicle
type: CellularLocationVocabulary
xref: GO GO:0008021 4

uniprot F7ASR8 76
type: UnificationXref
id: F7ASR8
db: uniprot

uniprot H2Q3W7 97
type: UnificationXref
id: H2Q3W7
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re20
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 308
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 309
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 6

ncbitaxon 3702 125
type: UnificationXref
id: 3702
db: ncbitaxon

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 28

uniprot P21137 231
type: UnificationXref
id: P21137
db: uniprot

Epinephrine
type: SmallMolecule
cellular location: synaptic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q922R0 251
organism: Mus musculus

TRANSPORT_LEFT__Epinephrine-RIGHT__Epinephrine-_re23
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 304
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 305
left: Epinephrine
interaction type: TRANSPORT
right: Epinephrine

TRIGGER
type: RelationshipTypeVocabulary

uniprot Q922R0 251
type: UnificationXref
id: Q922R0
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P68182 240
organism: Rattus norvegicus

uniprot E2RRA1 201
type: UnificationXref
id: E2RRA1
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: Relaxation of Bronchial Air Passage
controller: Ca2+

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68181 239
xref: PTHR24353:SF116
organism: Mus musculus

uniprot E2RGI5 45
type: UnificationXref
id: E2RGI5
db: uniprot

uniprot W4YRI6 253
type: UnificationXref
id: W4YRI6
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 105
organism: Homo sapiens

uniprot Q7PXF7 247
type: UnificationXref
id: Q7PXF7
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re12
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 313
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 312
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

uniprot Q3ZB92 243
type: UnificationXref
id: Q3ZB92
db: uniprot

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

TRIGGER
type: Control
xref: TRIGGER
controlled: Relaxation of Bronchial Air Passage
controller: Ca2+

Complex (GDP/G-Protein/_brBetasub_2/Epinephrine)
type: Complex
component stoichiometry: GDP s6 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Epinephrine s9 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s7 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta2 s8 sa8 STOICHIOMETRY ID COMPLEX
component: G-Protein
component: Beta2
component: Epinephrine
component: GDP
feature: COMPLEX BINDING FEATURE s64 a71 282
feature: COMPLEX BINDING FEATURE s64 a71 286
feature: COMPLEX BINDING FEATURE s64 a71 284
feature: COMPLEX BINDING FEATURE s64 a71 288
cellular location: cytosol

uniprot O60262 107
type: UnificationXref
id: O60262
db: uniprot

P04440
type: UnificationXref
id: P04440
db: PANTHER Pathway Component

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: uniprot A1L271 24
organism: Danio rerio

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 124
organism: Arabidopsis thaliana

P04443
type: UnificationXref
id: P04443
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 34
organism: Branchiostoma floridae

P04444
type: UnificationXref
id: P04444
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re17 311
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 310
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

P04446
type: UnificationXref
id: P04446
db: PANTHER Pathway Component

uniprot P62874 137
type: UnificationXref
id: P62874
db: uniprot

uniprot F6SSS3 64
type: UnificationXref
id: F6SSS3
db: uniprot

STATE_TRANSITION_LEFT__ER_type_Ca2_PLUS__channel-RIGHT__ER_type_Ca2_PLUS__channel-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 307
left: ER-type Ca2+ channel
interaction type: STATE_TRANSITION
right: ER-type Ca2+ channel

GO GO:0008021 4
type: UnificationXref
id: GO:0008021
db: GO

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 108
organism: Bos taurus

Protein kinase A catalytic subunit
type: ProteinReference
xref: uniprot Q27687 242
xref: PTHR24353:SF37
organism: Leishmania major

uniprot F6XWE8 71
type: UnificationXref
id: F6XWE8
db: uniprot

uniprot Q61016 169
type: UnificationXref
id: Q61016
db: uniprot

ncbitaxon 8364 28
type: UnificationXref
id: 8364
db: ncbitaxon

PTHR24248:SF21
type: RelationshipXref
id: PTHR24248:SF21
db: PANTHER Family
relationship type: By Homology

SNARE COMPLEX
type: Protein
cellular location: synaptic vesicle
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot F7H6T2 211
organism: Macaca mulatta

uniprot F7F580 87
type: UnificationXref
id: F7F580
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_Protein__brBetasub_1_-_Epinephrine-RIGHT__Complex__GDP_G_Protein__brBetasub_2_Epinephrine_-_re24
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 303
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 301
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 302
left: Complex (GDP/G-Protein/_brBetasub_1)
left: Epinephrine
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-Protein/_brBetasub_2/Epinephrine)

uniprot F7HAK5 212
type: UnificationXref
id: F7HAK5
db: uniprot

uniprot F6PV18 61
type: UnificationXref
id: F6PV18
db: uniprot

Ca2+
type: SmallMolecule
cellular location: sarcoplasmic reticulum
comment: SPECIES_TYPE=ION

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 92
organism: Macaca mulatta

uniprot F1RE11 55
type: UnificationXref
id: F1RE11
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CB49 78
organism: Monodelphis domestica

ncbitaxon 9031 38
type: UnificationXref
id: 9031
db: ncbitaxon

GDP s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot Q28509 17
type: UnificationXref
id: Q28509
db: uniprot

uniprot G3V6P8 93
type: UnificationXref
id: G3V6P8
db: uniprot

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
type: ProteinReference
xref: uniprot Q6R0H7 178
xref: PTHR10218:SF320
organism: Mus musculus

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 59
organism: Ornithorhynchus anatinus

uniprot Q7KPV0 180
type: UnificationXref
id: Q7KPV0
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 57
organism: Neurospora crassa

Guanine nucleotide-binding protein G(olf) subunit alpha
type: ProteinReference
xref: uniprot Q8CGK7 189
organism: Mus musculus

Protein kinase, X-linked
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q5BK52 244
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 44
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 123
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 27
organism: Xenopus tropicalis

Sympathetic neuron c7
type: CellularLocationVocabulary
comment: Sympathetic neuron

uniprot F1NLV4 53
type: UnificationXref
id: F1NLV4
db: uniprot

uniprot E2R2S3 41
type: UnificationXref
id: E2R2S3
db: uniprot

G-Protein
type: ProteinReference
xref: P04443
comment: ENTITY_REFERENCE_ID_DESC=Beta2 adrenergic receptor signaling pathway.PROTEIN.GENERIC.G-Protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Gnb2 protein
member entity reference: Uncharacterized protein
member entity reference: AGAP006521-PA
member entity reference: G protein, Subunit Alpha
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide binding protein, beta subunit
member entity reference: Guanine nucleotide-binding protein subunit beta-5b
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: Guanine nucleotide-binding protein G(f) subunit alpha
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: AGAP005913-PA
member entity reference: Guanine nucleotide-binding protein G(olf) subunit alpha
member entity reference: Guanine nucleotide-binding protein subunit beta-5
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: G protein subunit alpha L
member entity reference: G protein subunit gamma 5
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: G protein alpha s subunit
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: G protein subunit beta 3
member entity reference: Guanine nucleotide-binding protein beta subunit
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: AGAP001506-PA

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 106
organism: Homo sapiens

Beta2 s10 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta2
stoichiometric coefficient: 1.0

uniprot D3ZLD6 36
type: UnificationXref
id: D3ZLD6
db: uniprot

uniprot P63213 144
type: UnificationXref
id: P63213
db: uniprot

uniprot Q05337 151
type: UnificationXref
id: Q05337
db: uniprot

uniprot Q7Q3T7 248
type: UnificationXref
id: Q7Q3T7
db: uniprot

uniprot A5PKD6 29
type: UnificationXref
id: A5PKD6
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q28024 157
organism: Bos taurus

uniprot O14775 106
type: UnificationXref
id: O14775
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 71
organism: Monodelphis domestica

uniprot E2RHY4 46
type: UnificationXref
id: E2RHY4
db: uniprot

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P21137 231
xref: PTHR24353:SF117
organism: Caenorhabditis elegans

uniprot H9EQQ4 218
type: UnificationXref
id: H9EQQ4
db: uniprot

uniprot Q8CGK7 189
type: UnificationXref
id: Q8CGK7
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 43
organism: Canis lupus familiaris

uniprot Q7Q6D2 184
type: UnificationXref
id: Q7Q6D2
db: uniprot

uniprot E9GNI4 205
type: UnificationXref
id: E9GNI4
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 41
organism: Canis lupus familiaris

uniprot Q10282 153
type: UnificationXref
id: Q10282
db: uniprot

uniprot E2RRD1 202
type: UnificationXref
id: E2RRD1
db: uniprot

uniprot F7G7I9 90
type: UnificationXref
id: F7G7I9
db: uniprot

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 186
organism: Anopheles gambiae

MODULATION
type: RelationshipTypeVocabulary

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 184
organism: Anopheles gambiae

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 185
organism: Anopheles gambiae

uniprot Q9DAS9 192
type: UnificationXref
id: Q9DAS9
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 16

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 18

uniprot F6Q503 206
type: UnificationXref
id: F6Q503
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: PTHR24353:SF135
xref: uniprot Q6DBV8 245
organism: Danio rerio

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 60

Protein kinase, cAMP-dependent, catalytic, beta a
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q7T374 249
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 97
organism: Pan troglodytes

uniprot P62879 138
type: UnificationXref
id: P62879
db: uniprot

uniprot Q6PH57 177
type: UnificationXref
id: Q6PH57
db: uniprot

uniprot F7E427 82
type: UnificationXref
id: F7E427
db: uniprot

ncbitaxon 10090 14
type: UnificationXref
id: 10090
db: ncbitaxon

Epinephrine s11 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

uniprot P51817 238
type: UnificationXref
id: P51817
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 158
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 119
organism: Bos taurus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31324 236
xref: PTHR11635:SF156
organism: Mus musculus

Beta-2 adrenergic receptor
type: ProteinReference
xref: uniprot Q28044 15
xref: PTHR24248:SF21
organism: Bos taurus

uniprot P50151 127
type: UnificationXref
id: P50151
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot E2RRD1 202
organism: Canis lupus familiaris

G protein alpha s subunit
type: ProteinReference
xref: PTHR10218:SF212
xref: uniprot P20354 114
organism: Drosophila melanogaster

uniprot Q28024 157
type: UnificationXref
id: Q28024
db: uniprot

AGAP006521-PA
type: ProteinReference
xref: uniprot Q7Q5C3 183
organism: Anopheles gambiae

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 33

DISSOCIATION
type: RelationshipTypeVocabulary

AGAP008039-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q3T7 248
xref: PTHR24353:SF117
organism: Anopheles gambiae

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot A8XW88 199
xref: PTHR24353:SF117
organism: Caenorhabditis briggsae

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 275
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 50
organism: Dictyostelium purpureum

uniprot F6VPY1 67
type: UnificationXref
id: F6VPY1
db: uniprot

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa7 285
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6Y3N2 72
type: UnificationXref
id: F6Y3N2
db: uniprot

uniprot F1MJV4 257
type: UnificationXref
id: F1MJV4
db: uniprot

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: uniprot P12370 227
xref: PTHR24353:SF117
organism: Drosophila melanogaster

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 42

uniprot F7FXA9 88
type: UnificationXref
id: F7FXA9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 23
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 126
organism: Homo sapiens

uniprot H2R1G3 215
type: UnificationXref
id: H2R1G3
db: uniprot

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 99
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 127
organism: Homo sapiens

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 90
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 129
organism: Bos taurus

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q80TL1 267
xref: PTHR45627:SF6
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 128
organism: Mus musculus

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa6 283
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

G-Protein
type: Protein
entity reference: G-Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa4 279
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31323 235
xref: PTHR11635:SF156
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M3D6 22
organism: Bos taurus

uniprot P26769 262
type: UnificationXref
id: P26769
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 79
organism: Monodelphis domestica

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 38

ncbitaxon 284812 154
type: UnificationXref
id: 284812
db: ncbitaxon

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P12369 226
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re25 300
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12367 224
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P12368 225
xref: PTHR11635:SF153
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re10 292
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

G Protein s7 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

uniprot Q9GNR4 252
type: UnificationXref
id: Q9GNR4
db: uniprot

uniprot O14610 105
type: UnificationXref
id: O14610
db: uniprot

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51828 263
organism: Homo sapiens

uniprot F7EBE7 83
type: UnificationXref
id: F7EBE7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 91
organism: Monodelphis domestica

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot P51829 264
xref: PTHR45627:SF9
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re22 307
type: Stoichiometry
physical entity: ER-type Ca2+ channel
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 306
type: Stoichiometry
physical entity: ER-type Ca2+ channel
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P27791 234
organism: Rattus norvegicus

ncbitaxon 9913 16
type: UnificationXref
id: 9913
db: ncbitaxon

STATE_TRANSITION
type: RelationshipTypeVocabulary

Adrenoceptor beta 2
type: ProteinReference
xref: uniprot H2QRR3 5
xref: PTHR24248:SF21
organism: Pan troglodytes

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 174
organism: Danio rerio

uniprot F6Q9S4 207
type: UnificationXref
id: F6Q9S4
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot K7ADQ0 261
organism: Pan troglodytes

MODULATION
type: Control
xref: MODULATION
controlled: HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_Protein__brBetasub_1_-_Epinephrine-RIGHT__Complex__GDP_G_Protein__brBetasub_2_Epinephrine_-_re24
controller: salbutamol (Ventolin)

Ca2+ channel
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 93
organism: Rattus norvegicus

uniprot P30671 119
type: UnificationXref
id: P30671
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 164
organism: Cryptococcus neoformans

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 48
organism: Daphnia pulex

uniprot Q29450 266
type: UnificationXref
id: Q29450
db: uniprot

uniprot Q61017 170
type: UnificationXref
id: Q61017
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re9
controller: AC

ncbitaxon 9544 18
type: UnificationXref
id: 9544
db: ncbitaxon

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: uniprot P51817 238
xref: PTHR24353:SF133
organism: Homo sapiens

uniprot E1BW98 39
type: UnificationXref
id: E1BW98
db: uniprot

uniprot P38405 122
type: UnificationXref
id: P38405
db: uniprot

uniprot Q6DGZ5 172
type: UnificationXref
id: Q6DGZ5
db: uniprot

G protein, Subunit Alpha
type: ProteinReference
xref: uniprot Q7KPV0 180
organism: Caenorhabditis elegans

uniprot P63217 148
type: UnificationXref
id: P63217
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 98
organism: Pan troglodytes

uniprot Q7PPI8 246
type: UnificationXref
id: Q7PPI8
db: uniprot

Beta2
type: Protein
entity reference: Beta2
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa8 287
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 194
organism: Homo sapiens

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot Q29450 266
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PV18 61
xref: PTHR10218:SF320
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 150
organism: Rattus norvegicus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot F6Q503 206
xref: PTHR11635:SF156
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 149
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 148
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 62
organism: Monodelphis domestica

PANTHER Pathway P04378 1
type: UnificationXref
id: P04378
db: PANTHER Pathway

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 147
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 146
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 145
organism: Bos taurus

uniprot Q5ZJ03 167
type: UnificationXref
id: Q5ZJ03
db: uniprot

uniprot P62872 135
type: UnificationXref
id: P62872
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 144
organism: Mus musculus

uniprot F1LQT1 256
type: UnificationXref
id: F1LQT1
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 200

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 72
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 32
organism: Ixodes scapularis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 155
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 111

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot P81900 241
xref: PTHR11635:SF162
organism: Drosophila melanogaster

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot P22612 232
organism: Homo sapiens

uniprot P12367 224
type: UnificationXref
id: P12367
db: uniprot

uniprot H2QNS5 99
type: UnificationXref
id: H2QNS5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 69
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BS74 37
organism: Gallus gallus

GDP s6 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 118
organism: Drosophila melanogaster

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 192
organism: Mus musculus

ER-type Ca2+ channel
type: Protein
feature: ACTIVE 19
cellular location: sarcoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

uniprot Q7Q6D4 186
type: UnificationXref
id: Q7Q6D4
db: uniprot

uniprot F6W548 68
type: UnificationXref
id: F6W548
db: uniprot

uniprot P34099 237
type: UnificationXref
id: P34099
db: uniprot

uniprot F6ZAV4 259
type: UnificationXref
id: F6ZAV4
db: uniprot

uniprot F6PGC8 59
type: UnificationXref
id: F6PGC8
db: uniprot

uniprot F7EBQ5 209
type: UnificationXref
id: F7EBQ5
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 87
organism: Macaca mulatta

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 273
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 76
organism: Macaca mulatta

uniprot P11017 108
type: UnificationXref
id: P11017
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 191
organism: Mus musculus

uniprot P00517 221
type: UnificationXref
id: P00517
db: uniprot

uniprot P10608 11
type: UnificationXref
id: P10608
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 116
organism: Drosophila melanogaster

ncbitaxon 9606 10
type: UnificationXref
id: 9606
db: ncbitaxon

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot F6Q9S4 207
xref: PTHR11635:SF156
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 45
organism: Canis lupus familiaris

uniprot P18851 112
type: UnificationXref
id: P18851
db: uniprot

uniprot A7EDU2 30
type: UnificationXref
id: A7EDU2
db: uniprot

PARTICIPANT STOICHIOMETRY re10 293
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 81
organism: Monodelphis domestica

ER-type Ca2+ channel
type: Protein
cellular location: sarcoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 7739 35
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot P29829 118
type: UnificationXref
id: P29829
db: uniprot

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 161
organism: Emericella nidulans

STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 291
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 290
left: Ca2+ channel
interaction type: STATE_TRANSITION
right: Ca2+ channel

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H2QFK0 213
organism: Pan troglodytes

ncbitaxon 7668 254
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot F6ZDB2 74
type: UnificationXref
id: F6ZDB2
db: uniprot

uniprot P49177 124
type: UnificationXref
id: P49177
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

ncbitaxon 10116 12
type: UnificationXref
id: 10116
db: ncbitaxon

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 182

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot W4YRI6 253
xref: PTHR11635:SF162
organism: Strongylocentrotus purpuratus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 52
organism: Bos taurus

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot H2RER5 216
xref: PTHR11635:SF156
organism: Pan troglodytes

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 31

uniprot H2Q9G5 98
type: UnificationXref
id: H2Q9G5
db: uniprot

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 165

ncbitaxon 227321 162
type: UnificationXref
id: 227321
db: ncbitaxon

Epinephrine s9 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 110
organism: Caenorhabditis elegans

PTHR24353:SF133
type: RelationshipXref
id: PTHR24353:SF133
db: PANTHER Family
relationship type: By Homology

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot P26769 262
xref: PTHR45627:SF6
organism: Rattus norvegicus

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF67
type: RelationshipXref
id: PTHR24353:SF67
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 160
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 77
organism: Macaca mulatta

uniprot F1PJE5 54
type: UnificationXref
id: F1PJE5
db: uniprot

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 187
organism: Danio rerio

G protein subunit alpha L
type: ProteinReference
xref: uniprot F6XVE6 70
organism: Xenopus tropicalis

PKA
type: Protein
entity reference: PKA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7ES96 86
type: UnificationXref
id: F7ES96
db: uniprot

uniprot Q90Z40 190
type: UnificationXref
id: Q90Z40
db: uniprot

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 35

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6SSS3 64
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 96
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 68
organism: Macaca mulatta

Complex (Beta2/Epinephrine)
type: Complex
component stoichiometry: Epinephrine s11 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Beta2 s10 sa10 STOICHIOMETRY ID COMPLEX
component: Beta2
component: Epinephrine
feature: COMPLEX BINDING FEATURE s66 a75 268
feature: COMPLEX BINDING FEATURE s66 a75 270
cellular location: cytosol

sarcoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0016529 3

uniprot Q5KI86 164
type: UnificationXref
id: Q5KI86
db: uniprot

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

uniprot G3V8K2 94
type: UnificationXref
id: G3V8K2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 130
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 159
organism: Rattus norvegicus

uniprot F7H6T2 211
type: UnificationXref
id: F7H6T2
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 46
organism: Canis lupus familiaris

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P00515 220
xref: PTHR11635:SF153
organism: Bos taurus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P00517 221
organism: Bos taurus

PTHR24353:SF128
type: RelationshipXref
id: PTHR24353:SF128
db: PANTHER Family
relationship type: By Homology

uniprot F6V461 66
type: UnificationXref
id: F6V461
db: uniprot

uniprot Q5BJ11 163
type: UnificationXref
id: Q5BJ11
db: uniprot

PARTICIPANT STOICHIOMETRY re20 309
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 308
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot A1L271 24
type: UnificationXref
id: A1L271
db: uniprot

uniprot F7G3J2 89
type: UnificationXref
id: F7G3J2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 107
organism: Homo sapiens

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re23 305
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

uniprot P36408 120
type: UnificationXref
id: P36408
db: uniprot

PARTICIPANT STOICHIOMETRY re23 304
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

uniprot P62873 136
type: UnificationXref
id: P62873
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 63

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 103
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 36
organism: Rattus norvegicus

uniprot P00515 220
type: UnificationXref
id: P00515
db: uniprot

uniprot R4GKD1 197
type: UnificationXref
id: R4GKD1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 39
organism: Gallus gallus

uniprot P13861 228
type: UnificationXref
id: P13861
db: uniprot

Beta2
type: ProteinReference
xref: P04440
standard name: Beta2 adrenergic receptor
comment: ENTITY_REFERENCE_ID_DESC=Beta2 adrenergic receptor signaling pathway.PROTEIN.RECEPTOR.Beta_sub_2
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Beta-2 adrenergic receptor
member entity reference: Adrenoceptor beta 2

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re12 313
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 154

PARTICIPANT STOICHIOMETRY re12 312
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot A3KMS9 198
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF128
xref: uniprot H2RI77 217
organism: Pan troglodytes

uniprot P63216 147
type: UnificationXref
id: P63216
db: uniprot

uniprot E9AFM1 203
type: UnificationXref
id: E9AFM1
db: uniprot

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 293
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 292
left: PKA
interaction type: STATE_TRANSITION
right: PKA

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 89
organism: Monodelphis domestica

Adenylate cyclase
type: ProteinReference
xref: uniprot A0A1D5RHE7 255
xref: PTHR45627:SF6
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re25 296
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 299
type: Stoichiometry
physical entity: Complex (Beta2/Epinephrine)
stoichiometric coefficient: 1.0

uniprot P29387 117
type: UnificationXref
id: P29387
db: uniprot

PARTICIPANT STOICHIOMETRY re25 297
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/_brBetasub_2/Epinephrine)
stoichiometric coefficient: 1.0

ncbitaxon 7227 115
type: UnificationXref
id: 7227
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re25 298
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

AGAP004940-PA
type: ProteinReference
xref: uniprot Q7PPI8 246
xref: PTHR11635:SF162
organism: Anopheles gambiae

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re12
control type: ACTIVATION
controller: Ca2+ channel

ncbitaxon 367110 58
type: UnificationXref
id: 367110
db: ncbitaxon

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

uniprot Q6R0H7 178
type: UnificationXref
id: Q6R0H7
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 277
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P52287 130
type: UnificationXref
id: P52287
db: uniprot

uniprot P51828 263
type: UnificationXref
id: P51828
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 152
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re10
controller: cAMP

uniprot P63212 143
type: UnificationXref
id: P63212
db: uniprot

uniprot P12368 225
type: UnificationXref
id: P12368
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 171
organism: Xenopus tropicalis

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P05132 223
organism: Mus musculus

uniprot P05131 222
type: UnificationXref
id: P05131
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 179
organism: Danio rerio

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P05131 222
xref: PTHR24353:SF116
organism: Bos taurus

uniprot Q9UK08 195
type: UnificationXref
id: Q9UK08
db: uniprot

uniprot F7DL70 260
type: UnificationXref
id: F7DL70
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re20
control type: ACTIVATION
controller: ER-type Ca2+ channel

uniprot Q6DBV8 245
type: UnificationXref
id: Q6DBV8
db: uniprot

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 156
organism: Caenorhabditis elegans

uniprot F6PVT7 62
type: UnificationXref
id: F6PVT7
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 193
organism: Homo sapiens

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 29
organism: Bos taurus

uniprot P16520 109
type: UnificationXref
id: P16520
db: uniprot

uniprot F6TFY2 65
type: UnificationXref
id: F6TFY2
db: uniprot

uniprot A0A2I3SJ53 20
type: UnificationXref
id: A0A2I3SJ53
db: uniprot

uniprot F7G4Q0 210
type: UnificationXref
id: F7G4Q0
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 10

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 153
organism: Schizosaccharomyces pombe

Guanine nucleotide-binding protein G(olf) subunit alpha
type: ProteinReference
xref: uniprot P38405 122
organism: Homo sapiens

uniprot H2RER5 216
type: UnificationXref
id: H2RER5
db: uniprot

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

uniprot P63218 149
type: UnificationXref
id: P63218
db: uniprot

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

uniprot E2R9G5 44
type: UnificationXref
id: E2R9G5
db: uniprot

uniprot Q3SZ98 160
type: UnificationXref
id: Q3SZ98
db: uniprot

uniprot P20354 114
type: UnificationXref
id: P20354
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 47
organism: Canis lupus familiaris

uniprot K7E376 104
type: UnificationXref
id: K7E376
db: uniprot

uniprot Q7Q6D3 185
type: UnificationXref
id: Q7Q6D3
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 125

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H9EQQ4 218
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 112
organism: Saccharomyces cerevisiae

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot E2RRA1 201
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 176
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot F7HAK5 212
organism: Macaca mulatta

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 196
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 54
organism: Canis lupus familiaris

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 95
organism: Pan troglodytes

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 254

uniprot P68182 240
type: UnificationXref
id: P68182
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P22694 233
xref: PTHR24353:SF116
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__ER_type_Ca2_PLUS__channel-RIGHT__ER_type_Ca2_PLUS__channel-_re22
control type: ACTIVATION
controller: PKA

uniprot P12370 227
type: UnificationXref
id: P12370
db: uniprot

uniprot F6V001 258
type: UnificationXref
id: F6V001
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 195
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re9 295
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

uniprot P68181 239
type: UnificationXref
id: P68181
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 40
organism: Gallus gallus

Beta-2 adrenergic receptor
type: ProteinReference
xref: PTHR24248:SF21
xref: uniprot P18762 13
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re9 294
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q9HAV0 193
type: UnificationXref
id: Q9HAV0
db: uniprot

uniprot J9P702 102
type: UnificationXref
id: J9P702
db: uniprot

uniprot H2QRR3 5
type: UnificationXref
id: H2QRR3
db: uniprot

PRKAR2A isoform 1
type: ProteinReference
xref: uniprot K7AEL3 219
xref: PTHR11635:SF153
organism: Pan troglodytes

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 19
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9615 42
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q7PXP3 181
type: UnificationXref
id: Q7PXP3
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 25

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 197
organism: Gallus gallus

uniprot K7AE17 103
type: UnificationXref
id: K7AE17
db: uniprot

uniprot P62871 134
type: UnificationXref
id: P62871
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot Q8MJ44 250
organism: Canis lupus familiaris

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P13861 228
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 86
organism: Macaca mulatta

uniprot F7H6T7 92
type: UnificationXref
id: F7H6T7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GNI4 205
xref: PTHR24353:SF117
organism: Daphnia pulex

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 53
organism: Gallus gallus

Beta2 s8 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta2
stoichiometric coefficient: 1.0

Beta-2 adrenergic receptor
type: ProteinReference
xref: uniprot Q28509 17
xref: PTHR24248:SF21
organism: Macaca mulatta

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 94
organism: Rattus norvegicus

uniprot Q9W3J1 196
type: UnificationXref
id: Q9W3J1
db: uniprot

uniprot F7CB49 78
type: UnificationXref
id: F7CB49
db: uniprot

ncbitaxon 6945 33
type: UnificationXref
id: 6945
db: ncbitaxon

AGAP001384-PA
type: ProteinReference
xref: uniprot Q7PXF7 247
xref: PTHR24353:SF117
organism: Anopheles gambiae

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 21
organism: Pan troglodytes

uniprot Q80TL1 267
type: UnificationXref
id: Q80TL1
db: uniprot

Guanine nucleotide-binding protein G(f) subunit alpha
type: ProteinReference
xref: uniprot Q05337 151
organism: Drosophila melanogaster

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 30
organism: Sclerotinia sclerotiorum

uniprot P50154 129
type: UnificationXref
id: P50154
db: uniprot

AC
type: Protein
entity reference: AC
feature: ACTIVE 19
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9258 60
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot Q61011 168
type: UnificationXref
id: Q61011
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide, olfactory type
type: ProteinReference
xref: uniprot F1RE11 55
organism: Danio rerio

uniprot Q6TH03 179
type: UnificationXref
id: Q6TH03
db: uniprot

uniprot E9FUX0 48
type: UnificationXref
id: E9FUX0
db: uniprot

uniprot E1C795 40
type: UnificationXref
id: E1C795
db: uniprot

uniprot P16912 229
type: UnificationXref
id: P16912
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 73
organism: Monodelphis domestica

uniprot P26308 116
type: UnificationXref
id: P26308
db: uniprot

PTHR45627:SF9
type: RelationshipXref
id: PTHR45627:SF9
db: PANTHER Family
relationship type: By Homology

uniprot P50153 128
type: UnificationXref
id: P50153
db: uniprot

uniprot P27791 234
type: UnificationXref
id: P27791
db: uniprot

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

uniprot F5HH30 57
type: UnificationXref
id: F5HH30
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 121

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 56
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

ncbitaxon 7955 25
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot P12369 226
type: UnificationXref
id: P12369
db: uniprot

uniprot P07550 9
type: UnificationXref
id: P07550
db: uniprot

uniprot Q9UBI6 194
type: UnificationXref
id: Q9UBI6
db: uniprot

uniprot H2PZA6 95
type: UnificationXref
id: H2PZA6
db: uniprot

uniprot Q6P025 174
type: UnificationXref
id: Q6P025
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 104
organism: Monodelphis domestica

uniprot Q6DH55 173
type: UnificationXref
id: Q6DH55
db: uniprot

uniprot Q3KRE3 159
type: UnificationXref
id: Q3KRE3
db: uniprot

uniprot Q5XGD8 166
type: UnificationXref
id: Q5XGD8
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 188
organism: Mus musculus

uniprot A4IGZ2 27
type: UnificationXref
id: A4IGZ2
db: uniprot

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 173
organism: Danio rerio

uniprot Q28044 15
type: UnificationXref
id: Q28044
db: uniprot

ncbitaxon 13616 63
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot A3KMS9 198
type: UnificationXref
id: A3KMS9
db: uniprot

ncbitaxon 44689 121
type: UnificationXref
id: 44689
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 65
organism: Macaca mulatta

uniprot F2Z3T8 56
type: UnificationXref
id: F2Z3T8
db: uniprot

uniprot F1A421 50
type: UnificationXref
id: F1A421
db: uniprot

uniprot H2RI77 217
type: UnificationXref
id: H2RI77
db: uniprot

uniprot Q7Q5C3 183
type: UnificationXref
id: Q7Q5C3
db: uniprot

G Protein s4 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 190
organism: Danio rerio

uniprot K7ADQ0 261
type: UnificationXref
id: K7ADQ0
db: uniprot

uniprot E1BS74 37
type: UnificationXref
id: E1BS74
db: uniprot

uniprot F6ZIZ9 75
type: UnificationXref
id: F6ZIZ9
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 12

ncbitaxon 7165 182
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot A0A1D5RHE7 255
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 75
organism: Macaca mulatta

cAMP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2QZN8 100
type: UnificationXref
id: H2QZN8
db: uniprot

Epinephrine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa11 271
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 49

uniprot P63077 141
type: UnificationXref
id: P63077
db: uniprot

uniprot Q7T374 249
type: UnificationXref
id: Q7T374
db: uniprot

uniprot Q9CXP8 191
type: UnificationXref
id: Q9CXP8
db: uniprot

uniprot Q80SZ7 188
type: UnificationXref
id: Q80SZ7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 142
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 141
organism: Rattus norvegicus

Protein kinase A catalytic subunit isoform 2
type: ProteinReference
xref: PTHR24353:SF67
xref: uniprot E9AFM1 203
organism: Leishmania major

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2R3A6 101
type: UnificationXref
id: H2R3A6
db: uniprot

uniprot Q0VFC4 152
type: UnificationXref
id: Q0VFC4
db: uniprot

uniprot A0A3Q1NGS8 23
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

uniprot H2QXB9 214
type: UnificationXref
id: H2QXB9
db: uniprot

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 101
organism: Pan troglodytes

uniprot H2Q1D9 96
type: UnificationXref
id: H2Q1D9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 132
organism: Rattus norvegicus

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F6ZAV4 259
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 131
organism: Rattus norvegicus

uniprot Q6DF43 171
type: UnificationXref
id: Q6DF43
db: uniprot

uniprot F7ERP8 85
type: UnificationXref
id: F7ERP8
db: uniprot

uniprot F7CTP1 80
type: UnificationXref
id: F7CTP1
db: uniprot

AC
type: Protein
entity reference: AC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 294
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 295
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

STATE_TRANSITION
type: InteractionVocabulary

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 82
organism: Ornithorhynchus anatinus

TRANSPORT
type: InteractionVocabulary

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re11
control type: ACTIVATION
controller: PKA

Adenylate cyclase
type: ProteinReference
xref: uniprot F6V001 258
xref: PTHR45627:SF6
organism: Monodelphis domestica

uniprot P31324 236
type: UnificationXref
id: P31324
db: uniprot

Ca2+
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

GO GO:0016529 3
type: UnificationXref
id: GO:0016529
db: GO

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot F7G4Q0 210
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re11 290
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

PRKACG isoform 1
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot H2QXB9 214
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re11 291
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 177
organism: Danio rerio

Adenylate cyclase
type: ProteinReference
xref: uniprot F1MJV4 257
xref: PTHR45627:SF6
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re24 302
type: Stoichiometry
physical entity: Epinephrine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 303
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/_brBetasub_2/Epinephrine)
stoichiometric coefficient: 1.0

Ca2+ channel
type: Protein
feature: ACTIVE 19
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Beta2
type: Protein
entity reference: Beta2
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa10 269
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re24 301
type: Stoichiometry
physical entity: Complex (GDP/G-Protein/_brBetasub_1)
stoichiometric coefficient: 1.0

uniprot H2QFK0 213
type: UnificationXref
id: H2QFK0
db: uniprot

uniprot Q28H40 158
type: UnificationXref
id: Q28H40
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 51

Adenylate cyclase
type: ProteinReference
xref: uniprot F7DL70 260
xref: PTHR45627:SF9
organism: Macaca mulatta

uniprot F1MYW8 52
type: UnificationXref
id: F1MYW8
db: uniprot

uniprot A0A3Q1M3D6 22
type: UnificationXref
id: A0A3Q1M3D6
db: uniprot

uniprot Q8MJ44 250
type: UnificationXref
id: Q8MJ44
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 204

uniprot P50150 126
type: UnificationXref
id: P50150
db: uniprot

uniprot Q6PBY0 176
type: UnificationXref
id: Q6PBY0
db: uniprot

uniprot P22612 232
type: UnificationXref
id: P22612
db: uniprot

uniprot P05132 223
type: UnificationXref
id: P05132
db: uniprot

uniprot F6XVE6 70
type: UnificationXref
id: F6XVE6
db: uniprot

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

ncbitaxon 5786 51
type: UnificationXref
id: 5786
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZDB2 74
xref: PTHR10218:SF320
organism: Monodelphis domestica

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P34099 237
xref: PTHR24353:SF37
organism: Dictyostelium discoideum

uniprot F7CXD0 81
type: UnificationXref
id: F7CXD0
db: uniprot

Beta2 adrenergic receptor signaling pathway
type: Pathway
pathway component: TRANSPORT_LEFT__Epinephrine-RIGHT__Epinephrine-_re23
pathway component: TRIGGER
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re17
pathway component: DISSOCIATION_LEFT__GTP-_Complex__GDP_G_Protein__brBetasub_2_Epinephrine_-RIGHT__Complex__GTP_G_Protein_-_Complex__Beta2_Epinephrine_-_GDP-_re25
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re10
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_Protein__brBetasub_1_-_Epinephrine-RIGHT__Complex__GDP_G_Protein__brBetasub_2_Epinephrine_-_re24
pathway component: STATE_TRANSITION_LEFT__ER_type_Ca2_PLUS__channel-RIGHT__ER_type_Ca2_PLUS__channel-_re22
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re11
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re9
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re12
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re20
xref: PANTHER Pathway P04378 1
comment: MODEL_NOTES=Panther Pathway: P04378 No pathway definition

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot C3ZSF0 34
type: UnificationXref
id: C3ZSF0
db: uniprot

cAMP-dependent protein kinase catalytic subunit 3
type: ProteinReference
xref: uniprot P16912 229
xref: PTHR24353:SF37
organism: Drosophila melanogaster

ncbitaxon 214684 165
type: UnificationXref
id: 214684
db: ncbitaxon

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 85
organism: Ornithorhynchus anatinus

uniprot Q6PBR4 175
type: UnificationXref
id: Q6PBR4
db: uniprot

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 83
organism: Xenopus tropicalis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 67
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 66
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 109
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 133
organism: Homo sapiens

uniprot P17343 110
type: UnificationXref
id: P17343
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 120
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EJA3 84
xref: PTHR10218:SF320
organism: Ornithorhynchus anatinus

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 162

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Epinephrine-RIGHT__Epinephrine-_re23
control type: ACTIVATION
controller: SNARE COMPLEX

uniprot P63215 146
type: UnificationXref
id: P63215
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 175
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: uniprot Q3ZB92 243
xref: PTHR24353:SF116
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 172
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 102
organism: Canis lupus familiaris

GTP s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: uniprot F7EBQ5 209
xref: PTHR24353:SF116
organism: Macaca mulatta

Protein kinase A catalytic subunit isoform 1
type: ProteinReference
xref: PTHR24353:SF67
xref: uniprot Q9GNR4 252
organism: Leishmania major

ncbitaxon 6238 200
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot Q08462 265
type: UnificationXref
id: Q08462
db: uniprot