GP IX
type: Protein
entity reference: GP IX
feature: COMPLEX PARTICIPANT BINDING FEATURE s113 sa75 306
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

FXa s99 sa64 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FXa
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r147 428
type: Stoichiometry
physical entity: mPAR-3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r147 429
type: Stoichiometry
physical entity: mPAR-3
stoichiometric coefficient: 1.0

PROS1 isoform 1
type: ProteinReference
xref: PTHR24040:SF0
xref: uniprot H2QMY8 71
organism: Pan troglodytes

INHIBITION
type: Control
xref: INHIBITION
controlled: TRUNCATION_LEFT__FIX-RIGHT__FIXa-_?-_r157
control type: INHIBITION
controller: ATiii heparin complex

HMWK s9 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HMWK
stoichiometric coefficient: 1.0

uniprot Q63207 143
type: UnificationXref
id: Q63207
db: uniprot

uniprot F6QMC6 20
type: UnificationXref
id: F6QMC6
db: uniprot

uniprot P13224 163
type: UnificationXref
id: P13224
db: uniprot

Coagulation factor XII
type: ProteinReference
xref: uniprot P98140 180
xref: PTHR24264:SF46
organism: Bos taurus

Blood coagulation
type: Pathway
pathway component: TRUNCATION_LEFT__FIX-RIGHT__FIXa-_?-_r157
pathway component: DISSOCIATION_LEFT__Complex__PC_EPCR_-RIGHT__EPCR-_APC-_r132
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GP_V_GP_IX_-_GP_1bbeta-RIGHT__Complex__GP_IX_GP_1bbeta__GP_Ibalpha_GP_V_-_r144
pathway component: DISSOCIATION_LEFT__Complex__FXa_FVa__Ca2_PLUS__PL_-RIGHT__FVa-_FXa-_r165
pathway component: HETERODIMER_ASSOCIATION_LEFT__PS-_APC-RIGHT__Complex__PS_APC_-_r140
pathway component: TRUNCATION_LEFT__Complex__Kallikrein_HMWK_-RIGHT__Bradykinin-_Kininogen-_Kallikrein-_r168
pathway component: HETERODIMER_ASSOCIATION_LEFT__FV-_FXa-RIGHT__Complex__FXa_FVa__Ca2_PLUS__PL_-_r130
pathway component: STATE_TRANSITION_LEFT__tPA-RIGHT__tPA-_r87
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GP_IIb_GP_IIIa_-_Fibrinogen-RIGHT__Complex__GP_IIIa_GP_IIb__Fibrinogen_-_r161
pathway component: STATE_TRANSITION_LEFT__PC-RIGHT__APC-_r133
pathway component: STATE_TRANSITION_LEFT__PAR_1-RIGHT__PAR_1-_r148
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Tissue_Factor_FVIIa__PL_Ca2_PLUS___FXa_-_TFPI-RIGHT__Complex__TFPI_Tissue_Factor__FVIIa_FXa__PL_Ca2_PLUS__-_r128
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Thrombomodulin_Ca2_PLUS___PL_-_Thrombin-RIGHT__Complex__Thrombomodulin_Thrombin__Ca2_PLUS__PL_-_r135
pathway component: STATE_TRANSITION_LEFT__uPA-RIGHT__uPA-_r90
pathway component: TRUNCATION_LEFT__Prekallikrein-RIGHT__Kallikrein-_?-_r152
pathway component: TRUNCATION_LEFT__Complex__Tissue_Factor_PL__Ca2_PLUS__-_FVII-RIGHT__Complex__FVIIa_Tissue_Factor__PL_Ca2_PLUS__-_?-_r158
pathway component: TRUNCATION_LEFT__PC-RIGHT__APC-_?-_r155
pathway component: HETERODIMER_ASSOCIATION_LEFT__uPA-_uPAR-RIGHT__Complex__uPA_uPAR_-_r138
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Thrombomodulin_Ca2_PLUS___PL_-_Thrombin-RIGHT__Complex__Thrombomodulin_Thrombin__Ca2_PLUS__PL_-_r122
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__FXIa-RIGHT__FXIa-_re71
pathway component: TRUNCATION_LEFT__Complex__HMWK_FXI_-RIGHT__FXIa-_HMWK-_?-_r154
pathway component: STATE_TRANSITION_LEFT__Plasmin-RIGHT__Plasmin-_re69
pathway component: HETERODIMER_ASSOCIATION_LEFT__HMWK-_Kallikrein-RIGHT__Complex__Kallikrein_HMWK_-_r112
pathway component: UNKNOWN_TRANSITION_LEFT__Fibrin_monomer-RIGHT__Fibrin_polymer_cross_linked-_r163
pathway component: DISSOCIATION_LEFT__Complex__FIXa_Ca2_PLUS___FVIIIa_PL_-RIGHT__FVIIIa-_FIXa-_r166
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GP_IX_GP_1bbeta__GP_Ibalpha_GP_V_-_vWF-RIGHT__Complex__GP_IX_GP_V__GP_1bbeta_GP_Ibalpha__vWF_-_r145
pathway component: STATE_TRANSITION_LEFT__FXIIa_Zn2_PLUS__complex-RIGHT__FXIIa_Zn2_PLUS__complex-_re72
pathway component: STATE_TRANSITION_LEFT__Thrombin-RIGHT__Thrombin-_re70
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__ZPI_PZ_-_FXa-RIGHT__Complex__ZPI_PZ__FXa_Ca2_PLUS___PL_-_r137
pathway component: HETERODIMER_ASSOCIATION_LEFT__PS-_APC-RIGHT__Complex__PS_APC_-_r134
pathway component: HETERODIMER_ASSOCIATION_LEFT__FIXa-_FVIIIa-RIGHT__Complex__FIXa_Ca2_PLUS___FVIIIa_PL_-_r141
pathway component: TRUNCATION_LEFT__FXII-_Zn2_PLUS_-RIGHT__FXIIa_Zn2_PLUS__complex-_?-_r153
pathway component: TRUNCATION_LEFT__Plasminogen-RIGHT__Plasmin-_?-_r164
pathway component: STATE_TRANSITION_LEFT__FV-RIGHT__FV-_r129
pathway component: STATE_TRANSITION_LEFT__Complex__FVIIa_Tissue_Factor__PL_Ca2_PLUS__-RIGHT__Complex__FVIIa_Tissue_Factor__PL_Ca2_PLUS__-_re73
pathway component: TRUNCATION_LEFT__Complex__vWF_FVIII_-RIGHT__vWF-_FVIIIa-_?-_r156
pathway component: TRUNCATION_LEFT__FXIII-RIGHT__FXIIIa-_?-_r160
pathway component: TRUNCATION_LEFT__FX-RIGHT__FXa-_?-_r159
pathway component: STATE_TRANSITION_LEFT__Fibrin_polymer_cross_linked-RIGHT__a52_degraded-_r41
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__FVIIa_Tissue_Factor__PL_Ca2_PLUS__-_FXa-RIGHT__Complex__Tissue_Factor_FVIIa__PL_Ca2_PLUS___FXa_-_r127
pathway component: TRUNCATION_LEFT__Prothrombin-RIGHT__Thrombin-_?-_r167
pathway component: STATE_TRANSITION_LEFT__PAR_4-RIGHT__PAR_4-_r149
pathway component: STATE_TRANSITION_LEFT__mPAR_3-RIGHT__mPAR_3-_r147
pathway component: UNKNOWN_TRANSITION_LEFT__Fibrinogen-RIGHT__Fibrin_monomer-_r162
xref: PANTHER Pathway P00011 1
comment: MODEL_NOTES=Panther Pathway: P00011 The blood coagulation cascade and fibrinolytic pathway. Medline=10856975 Medline=12871284 free text=Loscalzo J., Schafer A.I. (ed). Thrombosis and Hemorrhage (Third Edition). Lippincott Williams & Wilkins (2003). PMID: 10856975 PMID: 12871284

GP IIb
type: Protein
entity reference: GP IIb
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa20 322
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

EPCR s21 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EPCR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__tPA-RIGHT__tPA-_r87
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 482
participant stoichiometry: PARTICIPANT STOICHIOMETRY r87 483
left: tPA
interaction type: STATE_TRANSITION
right: tPA

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__PC-RIGHT__APC-_?-_r155
controller: Complex (Thrombomodulin/Thrombin/ Ca2+/PL)

uniprot D3ZAC0 59
type: UnificationXref
id: D3ZAC0
db: uniprot

uPA
type: Protein
entity reference: uPA
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

uniprot Q64695 8
type: UnificationXref
id: Q64695
db: uniprot

uniprot Q8BH61 101
type: UnificationXref
id: Q8BH61
db: uniprot

uniprot F6UZ87 32
type: UnificationXref
id: F6UZ87
db: uniprot

uniprot P00742 142
type: UnificationXref
id: P00742
db: uniprot

FVIIa
type: Protein
entity reference: FVIIa
feature: COMPLEX PARTICIPANT BINDING FEATURE s87 sa45 352
comment: SPECIES_TYPE=PROTEIN

Thrombomodulin
type: ProteinReference
xref: P00457
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.Thrombomodulin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Thrombomodulin

PAR-1
type: ProteinReference
xref: P00404
standard name: Protease-activated receptor1
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.PAR-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Protease-activated receptor1 Synonym: PAR-1,coagulation factor II receptor,thrombin receptor Accession: P00404
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Proteinase-activated receptor 1
member entity reference: Coagulation factor II (Thrombin) receptor

Kininogen-1
type: ProteinReference
xref: uniprot P08934 82
xref: PTHR13814:SF12
organism: Rattus norvegicus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 9

Alpha-2-macroglobulin-P
type: ProteinReference
xref: uniprot Q6GQT1 131
xref: PTHR11412:SF150
organism: Mus musculus

Vitamin K-dependent protein Z
type: ProteinReference
xref: uniprot Q9CQW3 47
organism: Mus musculus

FIXa
type: ProteinReference
xref: P00422
standard name: Factor IXa
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Factor IXa Synonym: Christmas Factor,FIXa,antihemophilic factor B,plasma thromboplastin component, PTC Accession: P00422
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FIXa
member entity reference: Coagulation factor IX
member entity reference: Uncharacterized protein

ACTIVE 17
type: EntityFeature
comment: Active state

Thrombomodulin
type: ProteinReference
xref: uniprot O35370 210
xref: PTHR24036:SF5
organism: Rattus norvegicus

Coagulation factor VII
type: ProteinReference
xref: PTHR24278:SF26
xref: uniprot Q2F9P2 186
organism: Pan troglodytes

uniprot Q08761 75
type: UnificationXref
id: Q08761
db: uniprot

GP V s16 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP V
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24264:SF38
xref: uniprot F6YDX7 120
organism: Macaca mulatta

uniprot O88186 202
type: UnificationXref
id: O88186
db: uniprot

FXIIIa
type: Protein
entity reference: FXIIIa
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

uniprot Q6GQT1 131
type: UnificationXref
id: Q6GQT1
db: uniprot

FXII
type: Protein
entity reference: FXII
comment: SPECIES_TYPE=PROTEIN

uniprot P08592 146
type: UnificationXref
id: P08592
db: uniprot

FXIIa Zn2+ complex
type: Complex
component stoichiometry: Zn2 PLUS s78 a116 STOICHIOMETRY ID COMPLEX
component stoichiometry: FXIIa s29 a36 STOICHIOMETRY ID COMPLEX
component: Zn2+
component: FXIIa
feature: COMPLEX BINDING FEATURE s204 csa27 225
feature: COMPLEX BINDING FEATURE s204 csa27 223

Tissue Factor
type: ProteinReference
xref: P00450
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.Tissue Factor
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Tissue factor

uniprot Q66IF8 176
type: UnificationXref
id: Q66IF8
db: uniprot

Fibrinogen
type: Protein
entity reference: Fibrinogen
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: activated platelet response
controller: PAR-1

PTHR24254:SF10
type: RelationshipXref
id: PTHR24254:SF10
db: PANTHER Family
relationship type: By Homology

Coagulation factor VIII
type: ProteinReference
xref: PTHR24543:SF310
xref: uniprot F1PFS7 18
organism: Canis lupus familiaris

uniprot P11214 154
type: UnificationXref
id: P11214
db: uniprot

Prothrombin
type: ProteinReference
xref: uniprot A0A452DI66 83
xref: PTHR24254:SF10
organism: Bos taurus

Tissue factor pathway inhibitor
type: ProteinReference
xref: uniprot Q02445 92
xref: PTHR10083:SF328
organism: Rattus norvegicus

ncbitaxon 10116 15
type: UnificationXref
id: 10116
db: ncbitaxon

GP 1bbeta s110 sa72 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP 1bbeta
stoichiometric coefficient: 1.0

PL s108 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PL
stoichiometric coefficient: 1.0

uPA
type: Protein
entity reference: uPA
comment: SPECIES_TYPE=PROTEIN

Proteinase-activated receptor 1
type: ProteinReference
xref: PTHR24232:SF20
xref: uniprot P25116 13
organism: Homo sapiens

FVIII
type: Protein
entity reference: FVIII
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa30 244
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r149 425
type: Stoichiometry
physical entity: PAR-4
stoichiometric coefficient: 1.0

APC
type: Protein
entity reference: APC
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa2 300
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r149 424
type: Stoichiometry
physical entity: PAR-4
stoichiometric coefficient: 1.0

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 3

uniprot H2QS39 178
type: UnificationXref
id: H2QS39
db: uniprot

PL s64 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PL
stoichiometric coefficient: 1.0

ZPI s97 sa62 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ZPI
stoichiometric coefficient: 1.0

Plasmin
type: ProteinReference
xref: P00415
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.Plasmin
comment: ENTITY_REFERENCE_NOTES=Long Name: Plasmin Synonym: Synonym not specified Accession: P00415
member entity reference: Plasminogen

Thrombomodulin
type: Protein
entity reference: Thrombomodulin
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 sa22 264
comment: SPECIES_TYPE=PROTEIN

uniprot Q92071 219
type: UnificationXref
id: Q92071
db: uniprot

Plasma kallikrein
type: ProteinReference
xref: uniprot P03952 167
xref: PTHR24253:SF64
organism: Homo sapiens

uniprot H3BM21 217
type: UnificationXref
id: H3BM21
db: uniprot

uniprot P22457 184
type: UnificationXref
id: P22457
db: uniprot

uniprot F1PPG5 214
type: UnificationXref
id: F1PPG5
db: uniprot

von Willebrand factor
type: ProteinReference
xref: PTHR11339:SF361
xref: uniprot P04275 190
organism: Homo sapiens

uPAR s12 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: uPAR
stoichiometric coefficient: 1.0

Vitamin K-dependent protein C
type: ProteinReference
xref: PTHR24278:SF0
xref: uniprot P04070 117
organism: Homo sapiens

Alpha-1-antitrypsin
type: ProteinReference
xref: uniprot F6SEN6 106
xref: PTHR11461:SF165
organism: Macaca mulatta

FIXa
type: Protein
entity reference: FIXa
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

Complex (GP V/GP IX)
type: Complex
component stoichiometry: GP V s16 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP IX s17 sa12 STOICHIOMETRY ID COMPLEX
component: GP V
component: GP IX
feature: COMPLEX BINDING FEATURE s116 a172 381
feature: COMPLEX BINDING FEATURE s116 a172 379
cellular location: activated platelet c1

uniprot P28800 134
type: UnificationXref
id: P28800
db: uniprot

uniprot F6Y5D7 66
type: UnificationXref
id: F6Y5D7
db: uniprot

Tissue Factor s54 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tissue Factor
stoichiometric coefficient: 1.0

Platelet glycoprotein Ib alpha chain
type: ProteinReference
xref: uniprot O35930 192
xref: PTHR24373:SF278
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r138 459
type: Stoichiometry
physical entity: Complex (uPA/uPAR)
stoichiometric coefficient: 1.0

GP IIIa s27 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP IIIa
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r138 457
type: Stoichiometry
physical entity: uPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r138 458
type: Stoichiometry
physical entity: uPAR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r129 383
type: Stoichiometry
physical entity: FV
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r129 384
type: Stoichiometry
physical entity: FV
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Prekallikrein-RIGHT__Kallikrein-_?-_r152
controller: FXIIa Zn2+ complex

PL
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa179 294
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P01008 173
type: UnificationXref
id: P01008
db: uniprot

GP V
type: Protein
entity reference: GP V
feature: COMPLEX PARTICIPANT BINDING FEATURE s114 sa76 308
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

GP 1bbeta
type: Protein
entity reference: GP 1bbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa9 260
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

uniprot P01045 81
type: UnificationXref
id: P01045
db: uniprot

uniprot P07225 74
type: UnificationXref
id: P07225
db: uniprot

PTHR24278:SF28
type: RelationshipXref
id: PTHR24278:SF28
db: PANTHER Family
relationship type: By Homology

Tissue Factor
type: Protein
entity reference: Tissue Factor
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa35 284
comment: SPECIES_TYPE=PROTEIN

Endothelial protein C receptor
type: ProteinReference
xref: PTHR15349:SF0
xref: uniprot Q9UNN8 10
organism: Homo sapiens

uniprot P30558 16
type: UnificationXref
id: P30558
db: uniprot

PTHR24278:SF26
type: RelationshipXref
id: PTHR24278:SF26
db: PANTHER Family
relationship type: By Homology

uniprot H2Q8V0 126
type: UnificationXref
id: H2Q8V0
db: uniprot

uniprot P08514 63
type: UnificationXref
id: P08514
db: uniprot

GP IIb
type: Protein
entity reference: GP IIb
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa17 246
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

Proteinase-activated receptor 4
type: ProteinReference
xref: PTHR24232:SF22
xref: uniprot O88634 221
organism: Mus musculus

FXIIa
type: Protein
entity reference: FXIIa
feature: ACTIVE 17
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 a36 224
comment: SPECIES_TYPE=PROTEIN

Tissue factor
type: ProteinReference
xref: PTHR20859:SF22
xref: uniprot P30931 197
organism: Bos taurus

FXIII
type: Protein
entity reference: FXIII
comment: SPECIES_TYPE=PROTEIN

Tissue Factor s60 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tissue Factor
stoichiometric coefficient: 1.0

PTHR45785:SF3
type: RelationshipXref
id: PTHR45785:SF3
db: PANTHER Family
relationship type: By Homology

Integrin beta
type: ProteinReference
xref: PTHR10082:SF25
xref: uniprot F7FG54 216
organism: Macaca mulatta

SERPINC1 isoform 1
type: ProteinReference
xref: PTHR11461:SF53
xref: uniprot H2Q0N0 172
organism: Pan troglodytes

PTHR11461:SF191
type: RelationshipXref
id: PTHR11461:SF191
db: PANTHER Family
relationship type: By Homology

PTHR24278:SF31
type: RelationshipXref
id: PTHR24278:SF31
db: PANTHER Family
relationship type: By Homology

uniprot P42533 198
type: UnificationXref
id: P42533
db: uniprot

Complex (FXa/FVa/ Ca2+/PL)
type: Complex
component stoichiometry: FXa s91 sa49 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s93 sa51 STOICHIOMETRY ID COMPLEX
component stoichiometry: PL s94 sa52 STOICHIOMETRY ID COMPLEX
component stoichiometry: FVa s92 sa50 STOICHIOMETRY ID COMPLEX
component: FVa
component: FXa
component: PL
component: Ca2+
feature: ACTIVE 17
feature: COMPLEX BINDING FEATURE s163 a248 373
feature: COMPLEX BINDING FEATURE s163 a248 375
feature: COMPLEX BINDING FEATURE s163 a248 377
feature: COMPLEX BINDING FEATURE s163 a248 371

vWF
type: ProteinReference
xref: P00448
standard name: von Willebrand Factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: von Willebrand Factor Synonym: Synonym not specified Accession: P00448
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.vWF
member entity reference: von Willebrand factor
member entity reference: Uncharacterized protein
member entity reference: VWF isoform 2

GP1BB isoform 1
type: ProteinReference
xref: uniprot H2RCB6 162
xref: PTHR22650:SF7
organism: Pan troglodytes

Coagulation factor IX
type: ProteinReference
xref: PTHR24278:SF31
xref: uniprot Q95ND7 115
organism: Pan troglodytes

Serpin peptidase inhibitor, clade D (heparin cofactor), member 1
type: ProteinReference
xref: PTHR11461:SF30
xref: uniprot F6SP26 206
organism: Xenopus tropicalis

uniprot H2R909 2
type: UnificationXref
id: H2R909
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__HMWK_FXI_-RIGHT__FXIa-_HMWK-_?-_r154
controller: FXIIa Zn2+ complex

STATE_TRANSITION_LEFT__FXIIa_Zn2_PLUS__complex-RIGHT__FXIIa_Zn2_PLUS__complex-_re72
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re72 441
participant stoichiometry: PARTICIPANT STOICHIOMETRY re72 442
left: FXIIa Zn2+ complex
interaction type: STATE_TRANSITION
right: FXIIa Zn2+ complex

Thrombomodulin s45 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Thrombomodulin
stoichiometric coefficient: 1.0

uniprot P14770 203
type: UnificationXref
id: P14770
db: uniprot

PZ
type: Protein
entity reference: PZ
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 sa61 328
comment: SPECIES_TYPE=PROTEIN

FXIIa
type: ProteinReference
xref: P00441
standard name: Factor XIIa
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FXIIa
comment: ENTITY_REFERENCE_NOTES= Long Name: Factor XIIa Synonym: Hageman Factor Accession: P00441
member entity reference: Coagulation factor XII
member entity reference: Uncharacterized protein

Plasminogen
type: ProteinReference
xref: PTHR24261:SF13
xref: uniprot H2QU06 50
organism: Pan troglodytes

uniprot P30931 197
type: UnificationXref
id: P30931
db: uniprot

APC
type: ProteinReference
xref: P00423
standard name: Activated Protein C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.APC
comment: ENTITY_REFERENCE_NOTES=Long Name: Activated Protein C Synonym: FXIV,anticoagulant protein C,autoprothrombin IIA,vitamin K-dependent protein C Accession: P00423
member entity reference: Vitamin K-dependent protein C
member entity reference: PROC isoform 3

MODULATION
type: RelationshipTypeVocabulary

Amyloid-beta A4 protein
type: ProteinReference
xref: PTHR23103:SF7
xref: uniprot P08592 146
organism: Rattus norvegicus

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa37 288
comment: SPECIES_TYPE=ION

FXa
type: Protein
entity reference: FXa
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 21

Coagulation factor X
type: ProteinReference
xref: uniprot P00742 142
xref: PTHR24278:SF28
organism: Homo sapiens

PAR-4
type: Protein
entity reference: PAR-4
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

Complex (Tissue Factor/FVIIa/ PL/Ca2+/ FXa)
type: Complex
component stoichiometry: PL s82 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: FXa s84 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s83 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tissue Factor s75 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: FVIIa s81 sa39 STOICHIOMETRY ID COMPLEX
component: PL
component: FVIIa
component: Tissue Factor
component: FXa
component: Ca2+
feature: COMPLEX BINDING FEATURE s154 a231 337
feature: COMPLEX BINDING FEATURE s154 a231 335
feature: ACTIVE 17
feature: COMPLEX BINDING FEATURE s154 a231 331
feature: COMPLEX BINDING FEATURE s154 a231 329
feature: COMPLEX BINDING FEATURE s154 a231 333

Coagulation factor IX
type: ProteinReference
xref: PTHR24278:SF31
xref: uniprot P00740 111
organism: Homo sapiens

Coagulation factor IX
type: ProteinReference
xref: uniprot P00741 112
xref: PTHR24278:SF31
organism: Bos taurus

uniprot O88783 148
type: UnificationXref
id: O88783
db: uniprot

uniprot P08697 133
type: UnificationXref
id: P08697
db: uniprot

Prothrombin
type: ProteinReference
xref: PTHR24254:SF10
xref: uniprot P00734 86
organism: Homo sapiens

Platelet glycoprotein Ib beta chain
type: ProteinReference
xref: PTHR22650:SF7
xref: uniprot P13224 163
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11461:SF191
xref: uniprot F7F6Y0 125
organism: Macaca mulatta

ZPI
type: Protein
entity reference: ZPI
comment: SPECIES_TYPE=PROTEIN

Proteinase-activated receptor 1
type: ProteinReference
xref: PTHR24232:SF20
xref: uniprot P30558 16
organism: Mus musculus

PTHR11339:SF361
type: RelationshipXref
id: PTHR11339:SF361
db: PANTHER Family
relationship type: By Homology

uniprot H2QW33 152
type: UnificationXref
id: H2QW33
db: uniprot

Complex (GP IIb/GP IIIa)
type: Complex
component stoichiometry: GP IIIa s27 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP IIb s24 sa17 STOICHIOMETRY ID COMPLEX
component: GP IIb
component: GP IIIa
feature: COMPLEX BINDING FEATURE s126 a190 245
feature: COMPLEX BINDING FEATURE s126 a190 247
cellular location: activated platelet c1

Coagulation factor VII
type: ProteinReference
xref: PTHR24278:SF26
xref: uniprot P70375 185
organism: Mus musculus

EPCR
type: Protein
entity reference: EPCR
comment: SPECIES_TYPE=PROTEIN

Thrombin
type: Protein
entity reference: Thrombin
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa26 272
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

Platelet glycoprotein Ib beta chain
type: ProteinReference
xref: uniprot Q9JJM7 165
organism: Rattus norvegicus

uniprot P07204 211
type: UnificationXref
id: P07204
db: uniprot

TRUNCATION_LEFT__Complex__Tissue_Factor_PL__Ca2_PLUS__-_FVII-RIGHT__Complex__FVIIa_Tissue_Factor__PL_Ca2_PLUS__-_?-_r158
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r158 395
participant stoichiometry: PARTICIPANT STOICHIOMETRY r158 397
participant stoichiometry: PARTICIPANT STOICHIOMETRY r158 394
participant stoichiometry: PARTICIPANT STOICHIOMETRY r158 396
left: Complex (Tissue Factor/PL/ Ca2+)
left: FVII
interaction type: TRUNCATION
right: Complex (FVIIa/Tissue Factor/ PL/Ca2+)
right: ?

Plasminogen
type: ProteinReference
xref: uniprot Q01177 53
xref: PTHR24261:SF13
organism: Rattus norvegicus

uniprot O08619 98
type: UnificationXref
id: O08619
db: uniprot

PTHR11461:SF165
type: RelationshipXref
id: PTHR11461:SF165
db: PANTHER Family
relationship type: By Homology

FVa
type: Protein
entity reference: FVa
comment: SPECIES_TYPE=PROTEIN

uniprot P12388 57
type: UnificationXref
id: P12388
db: uniprot

uniprot P00451 23
type: UnificationXref
id: P00451
db: uniprot

FVa
type: ProteinReference
xref: P00435
standard name: Factor Va
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FVa
comment: ENTITY_REFERENCE_NOTES=Long Name: Factor Va Synonym: FVa,accelerator (Ac-) globulin,labile factor,proaccelerin Accession: P00435
member entity reference: Coagulation factor V

FV
type: Protein
entity reference: FV
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re72 441
type: Stoichiometry
physical entity: FXIIa Zn2+ complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re72 442
type: Stoichiometry
physical entity: FXIIa Zn2+ complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r161 499
type: Stoichiometry
physical entity: Complex (GP IIb/GP IIIa)
stoichiometric coefficient: 1.0

DISSOCIATION
type: RelationshipTypeVocabulary

ncbitaxon 9615 19
type: UnificationXref
id: 9615
db: ncbitaxon

HMWK
type: Protein
entity reference: HMWK
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa16 318
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: activated platelet response
controller: mPAR-3

Prothrombin
type: ProteinReference
xref: uniprot P18292 88
xref: PTHR24254:SF10
organism: Rattus norvegicus

DISSOCIATION_LEFT__Complex__FXa_FVa__Ca2_PLUS__PL_-RIGHT__FVa-_FXa-_r165
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r165 479
participant stoichiometry: PARTICIPANT STOICHIOMETRY r165 480
participant stoichiometry: PARTICIPANT STOICHIOMETRY r165 481
left: Complex (FXa/FVa/ Ca2+/PL)
interaction type: DISSOCIATION
right: FVa
right: FXa

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FY72 177
xref: PTHR24264:SF46
organism: Macaca mulatta

Urokinase plasminogen activator surface receptor
type: ProteinReference
xref: PTHR10624:SF6
xref: uniprot Q03405 158
organism: Homo sapiens

uniprot Q28105 6
type: UnificationXref
id: Q28105
db: uniprot

FXa
type: Protein
entity reference: FXa
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa42 338
comment: SPECIES_TYPE=PROTEIN

FXIIa s29 a36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FXIIa
stoichiometric coefficient: 1.0

Coagulation factor IX
type: ProteinReference
xref: PTHR24278:SF31
xref: uniprot P19540 114
organism: Canis lupus familiaris

uniprot H2Q0N0 172
type: UnificationXref
id: H2Q0N0
db: uniprot

PARTICIPANT STOICHIOMETRY r157 400
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__uPA-_uPAR-RIGHT__Complex__uPA_uPAR_-_r138
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r138 457
participant stoichiometry: PARTICIPANT STOICHIOMETRY r138 458
participant stoichiometry: PARTICIPANT STOICHIOMETRY r138 459
left: uPA
left: uPAR
interaction type: HETERODIMER_ASSOCIATION
right: Complex (uPA/uPAR)

PL
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s89 sa47 356
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6SRR1 215
type: UnificationXref
id: F6SRR1
db: uniprot

von Willebrand factor
type: ProteinReference
xref: PTHR11339:SF361
xref: uniprot G1K2B9 188
organism: Canis lupus familiaris

PL s94 sa52 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PL
stoichiometric coefficient: 1.0

Complex (Tissue Factor/PL/ Ca2+)
type: Complex
component stoichiometry: PL s55 sa32 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s58 sa33 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tissue Factor s54 sa31 STOICHIOMETRY ID COMPLEX
component: Ca2+
component: Tissue Factor
component: PL
feature: COMPLEX BINDING FEATURE s145 a221 255
feature: COMPLEX BINDING FEATURE s145 a221 253
feature: COMPLEX BINDING FEATURE s145 a221 257

Uncharacterized protein
type: ProteinReference
xref: PTHR23103:SF7
xref: uniprot E1C440 144
organism: Gallus gallus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Thrombin-RIGHT__Thrombin-_re70
control type: ACTIVATION
controller: HCII

uniprot P04275 190
type: UnificationXref
id: P04275
db: uniprot

FVII
type: ProteinReference
xref: P00454
standard name: Factor VII
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: FVII Synonym: Proconvertin,cothromboplastin,serum prothrombin conversion accelerator (SPCA) Accession: P00454
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FVII
member entity reference: Coagulation factor VII

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__FIX-RIGHT__FIXa-_?-_r157
controller: Complex (FVIIa/Tissue Factor/ PL/Ca2+)

FXa s84 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FXa
stoichiometric coefficient: 1.0

uniprot A0A2I3RL12 77
type: UnificationXref
id: A0A2I3RL12
db: uniprot

Coagulation factor VIII
type: ProteinReference
xref: PTHR24543:SF310
xref: uniprot H2R1R6 22
organism: Pan troglodytes

FXIIa
type: Protein
entity reference: FXIIa
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa175 228
comment: SPECIES_TYPE=PROTEIN

mPAR-3
type: ProteinReference
xref: P00452
standard name: mouse Protease-activated receptor 3
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.mPAR-3
comment: ENTITY_REFERENCE_NOTES=Long Name: mouse Protease-activated receptor 3 Synonym: mPAR-3 Accession: P00452
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Proteinase-activated receptor 3

GP IX
type: ProteinReference
xref: P00455
standard name: Glycoprotein IX
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.GP IX
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Glycoprotein 9
member entity reference: Platelet glycoprotein IX
member entity reference: GP9 isoform 1
member entity reference: Platelet glycoprotein IX polypeptide

uniprot E1B726 48
type: UnificationXref
id: E1B726
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__Thrombomodulin_Ca2_PLUS___PL_-_Thrombin-RIGHT__Complex__Thrombomodulin_Thrombin__Ca2_PLUS__PL_-_r122
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r122 408
participant stoichiometry: PARTICIPANT STOICHIOMETRY r122 409
participant stoichiometry: PARTICIPANT STOICHIOMETRY r122 410
left: Complex (Thrombomodulin/Ca2+/ PL)
left: Thrombin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Thrombomodulin/Thrombin/ Ca2+/PL)

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__FIXa_Ca2_PLUS___FVIIIa_PL_-RIGHT__FVIIIa-_FIXa-_r166
controller: Complex (PS/APC)

Plasminogen
type: ProteinReference
xref: PTHR24261:SF13
xref: uniprot F7CC91 49
organism: Macaca mulatta

uniprot P22777 70
type: UnificationXref
id: P22777
db: uniprot

Coagulation factor XII
type: ProteinReference
xref: uniprot H2QS39 178
xref: PTHR24264:SF46
organism: Pan troglodytes

FV
type: ProteinReference
xref: P00432
standard name: Factor V
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FV
comment: ENTITY_REFERENCE_NOTES=Long Name: Factor V Synonym: FV,Proaccelerin,accelerator (Ac-) globulin,labile factor Accession: P00432
member entity reference: Coagulation factor V

Ca2 PLUS s83 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

VWF isoform 2
type: ProteinReference
xref: PTHR11339:SF361
xref: uniprot H2Q597 189
organism: Pan troglodytes

PC s18 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PC
stoichiometric coefficient: 1.0

uniprot P25116 13
type: UnificationXref
id: P25116
db: uniprot

EPCR
type: ProteinReference
xref: P00403
standard name: Endothelial cell protein C receptor
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.EPCR
comment: ENTITY_REFERENCE_NOTES=Long Name: Endothelial cell protein C receptor Synonym: EPCR Accession: P00403
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: PROCR isoform 1
member entity reference: Endothelial protein C receptor

STATE_TRANSITION
type: RelationshipTypeVocabulary

EPCR
type: Protein
entity reference: EPCR
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa14 362
comment: SPECIES_TYPE=PROTEIN

PTHR15349:SF0
type: RelationshipXref
id: PTHR15349:SF0
db: PANTHER Family
relationship type: By Homology

TRUNCATION_LEFT__Plasminogen-RIGHT__Plasmin-_?-_r164
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r164 491
participant stoichiometry: PARTICIPANT STOICHIOMETRY r164 490
participant stoichiometry: PARTICIPANT STOICHIOMETRY r164 489
left: Plasminogen
interaction type: TRUNCATION
right: Plasmin
right: ?

PTHR23220:SF73
type: RelationshipXref
id: PTHR23220:SF73
db: PANTHER Family
relationship type: By Homology

Platelet glycoprotein IX polypeptide
type: ProteinReference
xref: PTHR22650:SF6
xref: uniprot B8XNP5 200
organism: Macaca mulatta

uniprot F1NUL9 30
type: UnificationXref
id: F1NUL9
db: uniprot

Plasminogen activator, tissue type
type: ProteinReference
xref: PTHR24264:SF42
xref: uniprot H2QW33 152
organism: Pan troglodytes

PTHR24373:SF278
type: RelationshipXref
id: PTHR24373:SF278
db: PANTHER Family
relationship type: By Homology

GP Ibalpha
type: Protein
entity reference: GP Ibalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s111 sa73 344
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

PTHR24264:SF38
type: RelationshipXref
id: PTHR24264:SF38
db: PANTHER Family
relationship type: By Homology

PAI-1
type: ProteinReference
xref: P00411
standard name: plasminogen activator inhibitor type-1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: plasminogen activator inhibitor type-1 Synonym: PAI-1,endothelial plasminogen activator inhibitor,serine (or cysteine) protease inhibitor, clade E, member 1 Accession: P00411
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.PAI-1
member entity reference: Uncharacterized protein
member entity reference: SERPINE1 isoform 1
member entity reference: Plasminogen activator inhibitor 1
member entity reference: Serpin family E member 1

alpha2-antiplasmin
type: Protein
entity reference: alpha2-antiplasmin
comment: SPECIES_TYPE=PROTEIN

Urokinase-type plasminogen activator
type: ProteinReference
xref: PTHR24264:SF38
xref: uniprot P15120 123
organism: Gallus gallus

GP Ibalpha
type: ProteinReference
xref: P00449
standard name: Glycoprotein Ibalpha
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.GP Ib_alpha_
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Platelet glycoprotein Ib alpha chain
member entity reference: Glycoprotein Ib platelet subunit alpha

Integrin beta (Fragment)
type: ProteinReference
xref: PTHR10082:SF25
xref: uniprot H3BM21 217
organism: Homo sapiens

uniprot Q05588 159
type: UnificationXref
id: Q05588
db: uniprot

Complex (GP IX/GP 1bbeta/ GP Ibalpha/GP V)
type: Complex
component stoichiometry: GP IX s109 sa71 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP 1bbeta s110 sa72 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP V s112 sa74 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP Ibalpha s111 sa73 STOICHIOMETRY ID COMPLEX
component: GP 1bbeta
component: GP Ibalpha
component: GP V
component: GP IX
feature: COMPLEX BINDING FEATURE s193 a316 341
feature: COMPLEX BINDING FEATURE s193 a316 345
feature: COMPLEX BINDING FEATURE s193 a316 339
feature: COMPLEX BINDING FEATURE s193 a316 343
cellular location: activated platelet c1

uniprot P05160 99
type: UnificationXref
id: P05160
db: uniprot

Complex (vWF/FVIII)
type: Complex
component stoichiometry: FVIII s51 sa30 STOICHIOMETRY ID COMPLEX
component stoichiometry: vWF s50 sa29 STOICHIOMETRY ID COMPLEX
component: vWF
component: FVIII
feature: COMPLEX BINDING FEATURE s141 a207 241
feature: COMPLEX BINDING FEATURE s141 a207 243

PTHR24040:SF0
type: RelationshipXref
id: PTHR24040:SF0
db: PANTHER Family
relationship type: By Homology

FXIIIa
type: ProteinReference
xref: P00419
standard name: Factor XIIIa
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FXIIIa
comment: ENTITY_REFERENCE_NOTES=Long Name: Factor XIIIa Synonym: FXIIIa,Protransglutaminase,fibrin stabilizing factor, FSF,fibrinoligase Accession: P00419
member entity reference: Coagulation factor XIII A chain
member entity reference: Coagulation factor XIII B chain
member entity reference: Uncharacterized protein

GP IIb s33 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP IIb
stoichiometric coefficient: 1.0

uniprot H2QEN1 55
type: UnificationXref
id: H2QEN1
db: uniprot

FXIIa Zn2+ complex
type: Complex
component stoichiometry: FXIIa s29 sa175 STOICHIOMETRY ID COMPLEX
component stoichiometry: Zn2 PLUS s78 sa176 STOICHIOMETRY ID COMPLEX
component: FXIIa
component: Zn2+
feature: COMPLEX BINDING FEATURE s204 csa29 229
feature: COMPLEX BINDING FEATURE s204 csa29 227

Kininogen
type: ProteinReference
xref: P00451
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=Long Name: Kininogen Synonym: Alpha-2-thiol proteinase inhibitor,KNG Accession: P00451
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.TRUNCATED.Kininogen
member entity reference: KNG1 isoform 2
member entity reference: Kininogen-1
member entity reference: Uncharacterized protein
member entity reference: Kininogen-2

uniprot P08709 183
type: UnificationXref
id: P08709
db: uniprot

KNG1 isoform 2
type: ProteinReference
xref: uniprot A0A2I3RL12 77
xref: PTHR13814:SF12
organism: Pan troglodytes

uniprot H2QD72 62
type: UnificationXref
id: H2QD72
db: uniprot

PTHR24264:SF46
type: RelationshipXref
id: PTHR24264:SF46
db: PANTHER Family
relationship type: By Homology

PTHR24264:SF42
type: RelationshipXref
id: PTHR24264:SF42
db: PANTHER Family
relationship type: By Homology

uniprot B8XNP5 200
type: UnificationXref
id: B8XNP5
db: uniprot

Tissue Factor s60 sa178 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tissue Factor
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r130 495
type: Stoichiometry
physical entity: FXa
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r164 490
type: Stoichiometry
physical entity: Plasmin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r130 496
type: Stoichiometry
physical entity: Complex (FXa/FVa/ Ca2+/PL)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r164 491
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r130 494
type: Stoichiometry
physical entity: FV
stoichiometric coefficient: 1.0

APC s8 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

vWF
type: Protein
entity reference: vWF
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa29 242
comment: SPECIES_TYPE=PROTEIN

GP IIIa
type: ProteinReference
xref: P00458
standard name: Glycoprotein IIIa
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.GP IIIa
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Integrin beta
member entity reference: Integrin beta (Fragment)
member entity reference: Integrin beta-3

Tissue factor pathway inhibitor
type: ProteinReference
xref: uniprot H2QJ44 90
xref: PTHR10083:SF328
organism: Pan troglodytes

HMWK
type: Protein
entity reference: HMWK
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa5 302
comment: SPECIES_TYPE=PROTEIN

Bradykinin
type: Protein
entity reference: Bradykinin
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r133 485
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r133 484
type: Stoichiometry
physical entity: PC
stoichiometric coefficient: 1.0

Complex (GP IX/GP V/ GP 1bbeta/GP Ibalpha/ vWF)
type: Complex
component stoichiometry: GP Ibalpha s118 sa78 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP 1bbeta s117 sa77 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP IX s113 sa75 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP V s114 sa76 STOICHIOMETRY ID COMPLEX
component stoichiometry: vWF s119 sa79 STOICHIOMETRY ID COMPLEX
component: GP IX
component: GP Ibalpha
component: vWF
component: GP V
component: GP 1bbeta
feature: COMPLEX BINDING FEATURE s198 a325 313
feature: COMPLEX BINDING FEATURE s198 a325 305
feature: COMPLEX BINDING FEATURE s198 a325 307
feature: COMPLEX BINDING FEATURE s198 a325 309
feature: COMPLEX BINDING FEATURE s198 a325 311
cellular location: activated platelet c1

PTHR20859:SF22
type: RelationshipXref
id: PTHR20859:SF22
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r164 489
type: Stoichiometry
physical entity: Plasminogen
stoichiometric coefficient: 1.0

uniprot F6SP26 206
type: UnificationXref
id: F6SP26
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__Thrombomodulin_Ca2_PLUS___PL_-_Thrombin-RIGHT__Complex__Thrombomodulin_Thrombin__Ca2_PLUS__PL_-_r135
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r135 472
participant stoichiometry: PARTICIPANT STOICHIOMETRY r135 471
participant stoichiometry: PARTICIPANT STOICHIOMETRY r135 470
left: Complex (Thrombomodulin/Ca2+/ PL)
left: Thrombin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Thrombomodulin/Thrombin/ Ca2+/PL)

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 sa48 358
comment: SPECIES_TYPE=ION

uniprot H2R6B3 220
type: UnificationXref
id: H2R6B3
db: uniprot

PARTICIPANT STOICHIOMETRY r152 420
type: Stoichiometry
physical entity: Kallikrein
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r152 421
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

PS
type: Protein
entity reference: PS
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa1 298
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

uniprot H2QJ44 90
type: UnificationXref
id: H2QJ44
db: uniprot

Integrin alpha-IIb
type: ProteinReference
xref: uniprot P08514 63
xref: PTHR23220:SF73
organism: Homo sapiens

PL s44 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PL
stoichiometric coefficient: 1.0

Fibrinogen s34 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fibrinogen
stoichiometric coefficient: 1.0

GP 1bbeta s117 sa77 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP 1bbeta
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PAR_1-RIGHT__PAR_1-_r148
controller: Thrombin

PARTICIPANT STOICHIOMETRY r163 492
type: Stoichiometry
physical entity: Fibrin monomer
stoichiometric coefficient: 1.0

FVIII s51 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FVIII
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r163 493
type: Stoichiometry
physical entity: Fibrin polymer cross-linked
stoichiometric coefficient: 1.0

tPA
type: Protein
entity reference: tPA
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

Tissue Factor s75 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tissue Factor
stoichiometric coefficient: 1.0

Coagulation factor XIII B chain
type: ProteinReference
xref: PTHR45785:SF3
xref: uniprot P05160 99
organism: Homo sapiens

Complex (Thrombomodulin/Ca2+/ PL)
type: Complex
component stoichiometry: Ca2 PLUS s40 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: PL s44 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: Thrombomodulin s39 sa22 STOICHIOMETRY ID COMPLEX
component: Ca2+
component: PL
component: Thrombomodulin
feature: COMPLEX BINDING FEATURE s137 a199 267
feature: COMPLEX BINDING FEATURE s137 a199 265
feature: COMPLEX BINDING FEATURE s137 a199 263

PL
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s108 sa70 370
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O35370 210
type: UnificationXref
id: O35370
db: uniprot

Coagulation factor X
type: ProteinReference
xref: PTHR24278:SF28
xref: uniprot F7FYL8 138
organism: Ornithorhynchus anatinus

Complex (Thrombomodulin/Thrombin/ Ca2+/PL)
type: Complex
component stoichiometry: Ca2 PLUS s48 sa27 STOICHIOMETRY ID COMPLEX
component stoichiometry: PL s49 sa28 STOICHIOMETRY ID COMPLEX
component stoichiometry: Thrombomodulin s45 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: Thrombin s46 sa26 STOICHIOMETRY ID COMPLEX
component: Ca2+
component: Thrombin
component: Thrombomodulin
component: PL
feature: COMPLEX BINDING FEATURE s140 a206 275
feature: COMPLEX BINDING FEATURE s140 a206 271
feature: COMPLEX BINDING FEATURE s140 a206 273
feature: COMPLEX BINDING FEATURE s140 a206 269

PARTICIPANT STOICHIOMETRY r152 419
type: Stoichiometry
physical entity: Prekallikrein
stoichiometric coefficient: 1.0

uniprot P14480 42
type: UnificationXref
id: P14480
db: uniprot

FVIIIa
type: Protein
entity reference: FVIIIa
feature: COMPLEX PARTICIPANT BINDING FEATURE s107 sa69 368
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PAR_4-RIGHT__PAR_4-_r149
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r149 424
participant stoichiometry: PARTICIPANT STOICHIOMETRY r149 425
left: PAR-4
interaction type: STATE_TRANSITION
right: PAR-4

Antithrombin-III
type: ProteinReference
xref: PTHR11461:SF53
xref: uniprot P32261 174
organism: Mus musculus

STATE_TRANSITION_LEFT__Fibrin_polymer_cross_linked-RIGHT__a52_degraded-_r41
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 423
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 422
left: Fibrin polymer cross-linked
interaction type: STATE_TRANSITION
right: a52_degraded

Glycoprotein Ib platelet subunit alpha
type: ProteinReference
xref: uniprot H2R9U1 191
xref: PTHR24373:SF278
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR11461:SF53
xref: uniprot F6Y0N9 171
organism: Macaca mulatta

FXI
type: ProteinReference
xref: P00460
standard name: Factor XI
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FXI
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Coagulation factor XI
member entity reference: Coagulation factor IX
member entity reference: Uncharacterized protein

PTHR24232:SF20
type: RelationshipXref
id: PTHR24232:SF20
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3RIA9 116
type: UnificationXref
id: A0A2I3RIA9
db: uniprot

ZPI
type: ProteinReference
xref: P00425
standard name: protein Z-dependent protease inhibitor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: protein Z-dependent protease inhibitor Synonym: ZPI Accession: P00425
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.ZPI
member entity reference: Protein Z-dependent protease inhibitor
member entity reference: Serpin family A member 10
member entity reference: Uncharacterized protein

PTHR24232:SF22
type: RelationshipXref
id: PTHR24232:SF22
db: PANTHER Family
relationship type: By Homology

FVIII
type: ProteinReference
xref: P00405
standard name: Factor VIII
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FVIII
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Coagulation factor VIII
member entity reference: Uncharacterized protein

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Plasminogen-RIGHT__Plasmin-_?-_r164
controller: uPA

uniprot F6SHG6 137
type: UnificationXref
id: F6SHG6
db: uniprot

PARTICIPANT STOICHIOMETRY r159 393
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

uniprot P15306 212
type: UnificationXref
id: P15306
db: uniprot

Complex (FVIIa/Tissue Factor/ PL/Ca2+)
type: Complex
component stoichiometry: PL s64 sa36 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tissue Factor s60 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s73 sa37 STOICHIOMETRY ID COMPLEX
component stoichiometry: FVIIa s59 sa34 STOICHIOMETRY ID COMPLEX
component: Tissue Factor
component: Ca2+
component: PL
component: FVIIa
feature: COMPLEX BINDING FEATURE s148 a224 287
feature: COMPLEX BINDING FEATURE s148 a224 285
feature: COMPLEX BINDING FEATURE s148 a224 283
feature: COMPLEX BINDING FEATURE s148 a224 281

PARTICIPANT STOICHIOMETRY r159 391
type: Stoichiometry
physical entity: FX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r159 392
type: Stoichiometry
physical entity: FXa
stoichiometric coefficient: 1.0

Thrombin s46 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Thrombin
stoichiometric coefficient: 1.0

uPA s11 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: uPA
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PAR_1-RIGHT__PAR_1-_r148
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r148 427
participant stoichiometry: PARTICIPANT STOICHIOMETRY r148 426
left: PAR-1
interaction type: STATE_TRANSITION
right: PAR-1

Fibrin polymer cross-linked
type: ProteinReference
xref: P00443
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.Fibrin polymer_br_cross-linked
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Fibrin polymer cross-linked Synonym: Synonym not specified Accession: P00443
member entity reference: Fibrinogen beta chain
member entity reference: Fibrinogen alpha chain
member entity reference: FGG isoform 5
member entity reference: FGB isoform 1
member entity reference: Uncharacterized protein
member entity reference: Fibrinogen gamma chain
member entity reference: FGA isoform 1
member entity reference: Fgb protein
member entity reference: Fibrinogen gamma-B chain

Plasmin
type: Protein
entity reference: Plasmin
comment: SPECIES_TYPE=PROTEIN

Zn2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

GP IX s109 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP IX
stoichiometric coefficient: 1.0

uniprot P34955 109
type: UnificationXref
id: P34955
db: uniprot

PROCR isoform 1
type: ProteinReference
xref: PTHR15349:SF0
xref: uniprot H2R909 2
organism: Pan troglodytes

PTHR24232:SF0
type: RelationshipXref
id: PTHR24232:SF0
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Prothrombin-RIGHT__Thrombin-_?-_r167
controller: Complex (FXa/FVa/ Ca2+/PL)

Amyloid-beta A4 protein
type: ProteinReference
xref: PTHR23103:SF7
xref: uniprot P12023 147
organism: Mus musculus

uniprot P10646 91
type: UnificationXref
id: P10646
db: uniprot

mPAR-3
type: Protein
entity reference: mPAR-3
feature: ACTIVE 17
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

uniprot O88634 221
type: UnificationXref
id: O88634
db: uniprot

Plasmin
type: Protein
entity reference: Plasmin
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r90 454
type: Stoichiometry
physical entity: uPA
stoichiometric coefficient: 1.0

FXIIa s29 sa175 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FXIIa
stoichiometric coefficient: 1.0

uniprot Q61838 130
type: UnificationXref
id: Q61838
db: uniprot

PARTICIPANT STOICHIOMETRY r90 453
type: Stoichiometry
physical entity: uPA
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24278:SF28
xref: uniprot F6SHG6 137
organism: Macaca mulatta

uPAR
type: ProteinReference
xref: P00433
standard name: urokinase-type plasminogen activator receptor
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.uPAR
comment: ENTITY_REFERENCE_NOTES=Long Name: urokinase-type plasminogen activator receptor Synonym: CD87,uPAR Accession: P00433
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Urokinase plasminogen activator surface receptor
member entity reference: Urokinase-type plasminogen activator
member entity reference: PLAU isoform 1
member entity reference: Uncharacterized protein

Coagulation factor XIII A chain
type: ProteinReference
xref: PTHR11590:SF42
xref: uniprot O08619 98
organism: Rattus norvegicus

Ca2 PLUS s106 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot Q05589 124
type: UnificationXref
id: Q05589
db: uniprot

PARTICIPANT STOICHIOMETRY r112 435
type: Stoichiometry
physical entity: Complex (Kallikrein/HMWK)
stoichiometric coefficient: 1.0

GP Ibalpha s14 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP Ibalpha
stoichiometric coefficient: 1.0

uniprot P02676 37
type: UnificationXref
id: P02676
db: uniprot

PAR-1
type: Protein
entity reference: PAR-1
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

PL s89 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PL
stoichiometric coefficient: 1.0

ATIII s203 sa172 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ATIII
stoichiometric coefficient: 1.0

Plasminogen activator inhibitor 1
type: ProteinReference
xref: PTHR11461:SF49
xref: uniprot P05121 68
organism: Homo sapiens

Vitamin K-dependent protein S (Fragment)
type: ProteinReference
xref: uniprot Q28520 76
xref: PTHR24040:SF0
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r112 434
type: Stoichiometry
physical entity: Kallikrein
stoichiometric coefficient: 1.0

Coagulation factor V
type: ProteinReference
xref: PTHR24543:SF302
xref: uniprot O88783 148
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r112 433
type: Stoichiometry
physical entity: HMWK
stoichiometric coefficient: 1.0

Plasminogen activator inhibitor 2
type: ProteinReference
xref: PTHR11461:SF61
xref: uniprot P05120 56
organism: Homo sapiens

GP Ibalpha
type: Protein
entity reference: GP Ibalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s118 sa78 312
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

PS s7 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PS
stoichiometric coefficient: 1.0

Antithrombin-III
type: ProteinReference
xref: PTHR11461:SF53
xref: uniprot P01008 173
organism: Homo sapiens

FVIIa s59 sa177 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FVIIa
stoichiometric coefficient: 1.0

Alpha-1-antitrypsin
type: ProteinReference
xref: uniprot P01009 107
xref: PTHR11461:SF165
organism: Homo sapiens

uniprot Q9CQW3 47
type: UnificationXref
id: Q9CQW3
db: uniprot

uniprot A0A452DI66 83
type: UnificationXref
id: A0A452DI66
db: uniprot

uniprot F7GHR4 110
type: UnificationXref
id: F7GHR4
db: uniprot

uniprot P17475 108
type: UnificationXref
id: P17475
db: uniprot

Kallikrein
type: ProteinReference
xref: P00437
standard name: kallikrein
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.Kallikrein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: kallikrein Synonym: Fletcher factor Accession: P00437
member entity reference: Plasma kallikrein
member entity reference: Uncharacterized protein

uniprot Q28107 149
type: UnificationXref
id: Q28107
db: uniprot

uniprot P56400 164
type: UnificationXref
id: P56400
db: uniprot

alpha2-macroglobulin
type: ProteinReference
xref: P00427
standard name: alpha-2-macroglobulin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC._alpha_2-macroglobulin
comment: ENTITY_REFERENCE_NOTES=Long Name: alpha-2-macroglobulin Synonym: alpha2M Accession: P00427
member entity reference: Pregnancy zone protein
member entity reference: Alpha-2-macroglobulin
member entity reference: Alpha-2-macroglobulin-P

Tissue-type plasminogen activator
type: ProteinReference
xref: uniprot A0A452DIF6 151
xref: PTHR24264:SF42
organism: Bos taurus

FVIIa
type: Protein
entity reference: FVIIa
feature: ACTIVE 17
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa34 282
comment: SPECIES_TYPE=PROTEIN

uPA
type: ProteinReference
xref: P00424
standard name: urokinase plasminogen activator
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: urokinase plasminogen activator Synonym: uPA Accession: P00424
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.uPA
member entity reference: Urokinase-type plasminogen activator
member entity reference: PLAU isoform 1
member entity reference: Uncharacterized protein

PARTICIPANT STOICHIOMETRY r154 411
type: Stoichiometry
physical entity: Complex (HMWK/FXI)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r154 412
type: Stoichiometry
physical entity: FXIa
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r154 413
type: Stoichiometry
physical entity: HMWK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r154 414
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

TFPI s85 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TFPI
stoichiometric coefficient: 1.0

uniprot F1MTN1 213
type: UnificationXref
id: F1MTN1
db: uniprot

Kininogen-1
type: ProteinReference
xref: uniprot O08677 79
xref: PTHR13814:SF12
organism: Mus musculus

TRUNCATION_LEFT__Prothrombin-RIGHT__Thrombin-_?-_r167
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r167 469
participant stoichiometry: PARTICIPANT STOICHIOMETRY r167 468
participant stoichiometry: PARTICIPANT STOICHIOMETRY r167 467
left: Prothrombin
interaction type: TRUNCATION
right: Thrombin
right: ?

PARTICIPANT STOICHIOMETRY r137 460
type: Stoichiometry
physical entity: Complex (ZPI/PZ)
stoichiometric coefficient: 1.0

uniprot H2R9U1 191
type: UnificationXref
id: H2R9U1
db: uniprot

Proteinase-activated receptor 3
type: ProteinReference
xref: PTHR24232:SF0
xref: uniprot O08675 199
organism: Mus musculus

Fibrin monomer
type: ProteinReference
xref: P00418
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Fibrin monomer Synonym: Synonym not specified Accession: P00418
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.Fibrin monomer
member entity reference: Fibrinogen beta chain
member entity reference: Fibrinogen alpha chain
member entity reference: FGG isoform 5
member entity reference: FGB isoform 1
member entity reference: Uncharacterized protein
member entity reference: Fibrinogen gamma chain
member entity reference: FGA isoform 1
member entity reference: Fgb protein
member entity reference: Fibrinogen gamma-B chain

PARTICIPANT STOICHIOMETRY r137 462
type: Stoichiometry
physical entity: Complex (ZPI/PZ/ FXa/Ca2+/ PL)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r137 461
type: Stoichiometry
physical entity: FXa
stoichiometric coefficient: 1.0

PN2
type: ProteinReference
xref: P00429
standard name: Protease nexin II
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.PN2
comment: ENTITY_REFERENCE_NOTES=Long Name: Protease nexin II Synonym: A4,AAA,AD1,Alzheimer's disease amyloid A4 protein precursor ,CVAP,PN2,amyloid beta (A4) precursor protein (APP) Accession: P00429
member entity reference: Amyloid-beta precursor protein
member entity reference: Uncharacterized protein
member entity reference: Amyloid-beta A4 protein

uniprot F7FY72 177
type: UnificationXref
id: F7FY72
db: uniprot

PARTICIPANT STOICHIOMETRY r155 406
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r155 405
type: Stoichiometry
physical entity: PC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r155 407
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

uniprot H2QMY8 71
type: UnificationXref
id: H2QMY8
db: uniprot

uniprot P07224 72
type: UnificationXref
id: P07224
db: uniprot

uniprot O35930 192
type: UnificationXref
id: O35930
db: uniprot

PC
type: ProteinReference
xref: P00426
standard name: Protein C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.PC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein C Synonym: FXIV,PC,anticoagulant protein C,autoprothrombin IIA,vitamin K-dependent protein C Accession: P00426
member entity reference: Vitamin K-dependent protein C
member entity reference: PROC isoform 3

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa27 274
comment: SPECIES_TYPE=ION

Serpin family B member 2
type: ProteinReference
xref: PTHR11461:SF61
xref: uniprot H2QEN1 55
organism: Pan troglodytes

Complex (ZPI/PZ)
type: Complex
component stoichiometry: PZ s96 sa61 STOICHIOMETRY ID COMPLEX
component stoichiometry: ZPI s95 sa60 STOICHIOMETRY ID COMPLEX
component: ZPI
component: PZ
feature: COMPLEX BINDING FEATURE s177 a283 327
feature: COMPLEX BINDING FEATURE s177 a283 325

Plasminogen
type: ProteinReference
xref: PTHR24261:SF13
xref: uniprot P00747 51
organism: Homo sapiens

Vitamin K-dependent protein Z
type: ProteinReference
xref: uniprot P00744 45
organism: Bos taurus

uniprot F1QFP3 181
type: UnificationXref
id: F1QFP3
db: uniprot

Coagulation factor XII
type: ProteinReference
xref: PTHR24264:SF46
xref: uniprot P00748 179
organism: Homo sapiens

Danio rerio
type: BioSource
xref: ncbitaxon 7955 182

Urokinase-type plasminogen activator
type: ProteinReference
xref: uniprot P00749 122
xref: PTHR24264:SF38
organism: Homo sapiens

Endothelial protein C receptor
type: ProteinReference
xref: PTHR15349:SF0
xref: uniprot Q28105 6
organism: Bos taurus

Tissue-type plasminogen activator
type: ProteinReference
xref: uniprot P00750 153
xref: PTHR24264:SF42
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__tPA-RIGHT__tPA-_r87
controller: Kallikrein

Coagulation factor V
type: ProteinReference
xref: uniprot Q28107 149
xref: PTHR24543:SF302
organism: Bos taurus

uniprot P05067 145
type: UnificationXref
id: P05067
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Plasmin-RIGHT__Plasmin-_re69
controller: alpha2-macroglobulin

uniprot H2Q597 189
type: UnificationXref
id: H2Q597
db: uniprot

Coagulation factor XI
type: ProteinReference
xref: PTHR24253:SF44
xref: uniprot A0A0G2K4I9 160
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r168 463
type: Stoichiometry
physical entity: Complex (Kallikrein/HMWK)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r168 464
type: Stoichiometry
physical entity: Bradykinin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r168 465
type: Stoichiometry
physical entity: Kininogen
stoichiometric coefficient: 1.0

Complex (TFPI/Tissue Factor/ FVIIa/FXa/ PL/Ca2+)
type: Complex
component stoichiometry: TFPI s85 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: FXa s88 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tissue Factor s86 sa44 STOICHIOMETRY ID COMPLEX
component stoichiometry: FVIIa s87 sa45 STOICHIOMETRY ID COMPLEX
component stoichiometry: PL s89 sa47 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s90 sa48 STOICHIOMETRY ID COMPLEX
component: FVIIa
component: Tissue Factor
component: PL
component: Ca2+
component: TFPI
component: FXa
feature: COMPLEX BINDING FEATURE s159 a242 355
feature: COMPLEX BINDING FEATURE s159 a242 357
feature: COMPLEX BINDING FEATURE s159 a242 353
feature: COMPLEX BINDING FEATURE s159 a242 351
feature: COMPLEX BINDING FEATURE s159 a242 347
feature: COMPLEX BINDING FEATURE s159 a242 349

PARTICIPANT STOICHIOMETRY r168 466
type: Stoichiometry
physical entity: Kallikrein
stoichiometric coefficient: 1.0

FXIII
type: ProteinReference
xref: P00453
standard name: Factor XIII
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Factor XIII Synonym: FXIII,Protransglutaminase,fibrin stabilizing factor, FSF,fibrinoligase Accession: P00453
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FXIII
member entity reference: Coagulation factor XIII A chain
member entity reference: Coagulation factor XIII B chain
member entity reference: Uncharacterized protein

uniprot P18292 88
type: UnificationXref
id: P18292
db: uniprot

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s83 sa41 336
comment: SPECIES_TYPE=ION

uniprot P00749 122
type: UnificationXref
id: P00749
db: uniprot

TRUNCATION_LEFT__Complex__vWF_FVIII_-RIGHT__vWF-_FVIIIa-_?-_r156
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r156 401
participant stoichiometry: PARTICIPANT STOICHIOMETRY r156 403
participant stoichiometry: PARTICIPANT STOICHIOMETRY r156 404
participant stoichiometry: PARTICIPANT STOICHIOMETRY r156 402
left: Complex (vWF/FVIII)
interaction type: TRUNCATION
right: vWF
right: FVIIIa
right: ?

Platelet glycoprotein IX
type: ProteinReference
xref: PTHR22650:SF6
xref: uniprot P14770 203
organism: Homo sapiens

HCII
type: Protein
entity reference: HCII
comment: SPECIES_TYPE=PROTEIN

uniprot P02671 35
type: UnificationXref
id: P02671
db: uniprot

uniprot H2RF34 201
type: UnificationXref
id: H2RF34
db: uniprot

Vitamin K-dependent protein C
type: ProteinReference
xref: PTHR24278:SF0
xref: uniprot P33587 119
organism: Mus musculus

uniprot P06869 156
type: UnificationXref
id: P06869
db: uniprot

Coagulation factor VII
type: ProteinReference
xref: PTHR24278:SF26
xref: uniprot P08709 183
organism: Homo sapiens

STATE_TRANSITION_LEFT__FV-RIGHT__FV-_r129
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r129 383
participant stoichiometry: PARTICIPANT STOICHIOMETRY r129 384
left: FV
interaction type: STATE_TRANSITION
right: FV

eco ECO:0000305 87
type: UnificationXref
id: ECO:0000305
db: eco

PARTICIPANT STOICHIOMETRY r144 436
type: Stoichiometry
physical entity: Complex (GP V/GP IX)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r144 437
type: Stoichiometry
physical entity: GP 1bbeta
stoichiometric coefficient: 1.0

Alpha-2-antiplasmin
type: ProteinReference
xref: uniprot Q61247 135
xref: PTHR11461:SF20
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r144 438
type: Stoichiometry
physical entity: Complex (GP IX/GP 1bbeta/ GP Ibalpha/GP V)
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__uPA-RIGHT__uPA-_r90
controller: Kallikrein

FXIa
type: Protein
entity reference: FXIa
comment: SPECIES_TYPE=PROTEIN

uniprot P07359 193
type: UnificationXref
id: P07359
db: uniprot

ATIII
type: ProteinReference
xref: P00440
standard name: Antithrombin III
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.ATIII
comment: ENTITY_REFERENCE_NOTES= Long Name: Antithrombin III Synonym: ATIII Accession: P00440
member entity reference: Serpin family C member 1
member entity reference: Uncharacterized protein
member entity reference: Antithrombin-III
member entity reference: SERPINC1 isoform 1
member entity reference: MGC89905 protein

MGC89905 protein
type: ProteinReference
xref: PTHR11461:SF53
xref: uniprot Q66IF8 176
organism: Xenopus tropicalis

alpha2-antiplasmin
type: ProteinReference
xref: P00428
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC._alpha_2-antiplasmin
comment: ENTITY_REFERENCE_NOTES=Long Name: alpha2-antiplasmin Synonym: Alpha-2-AP,Alpha-2-PI,plasmin inhibitor alpha2,serine (or cysteine) protease inhibitor, clade F, member 2 Accession: P00428
member entity reference: Alpha-2-antiplasmin
member entity reference: Uncharacterized protein

Serpin family C member 1
type: ProteinReference
xref: PTHR11461:SF53
xref: uniprot E2RES2 170
organism: Canis lupus familiaris

HETERODIMER_ASSOCIATION_LEFT__Complex__ZPI_PZ_-_FXa-RIGHT__Complex__ZPI_PZ__FXa_Ca2_PLUS___PL_-_r137
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r137 461
participant stoichiometry: PARTICIPANT STOICHIOMETRY r137 460
participant stoichiometry: PARTICIPANT STOICHIOMETRY r137 462
left: Complex (ZPI/PZ)
left: FXa
interaction type: HETERODIMER_ASSOCIATION
right: Complex (ZPI/PZ/ FXa/Ca2+/ PL)

uniprot H2QQB4 33
type: UnificationXref
id: H2QQB4
db: uniprot

uPAR
type: Protein
entity reference: uPAR
comment: SPECIES_TYPE=PROTEIN

uniprot Q28874 94
type: UnificationXref
id: Q28874
db: uniprot

PTHR24278:SF0
type: RelationshipXref
id: PTHR24278:SF0
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Thrombin-RIGHT__Thrombin-_re70
control type: ACTIVATION
controller: alpha2-macroglobulin

uniprot P12799 40
type: UnificationXref
id: P12799
db: uniprot

uniprot Q4AEG0 204
type: UnificationXref
id: Q4AEG0
db: uniprot

PTHR47221:SF1
type: RelationshipXref
id: PTHR47221:SF1
db: PANTHER Family
relationship type: By Homology

Thrombomodulin
type: ProteinReference
xref: PTHR24036:SF5
xref: uniprot P07204 211
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__PS-_APC-RIGHT__Complex__PS_APC_-_r134
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r134 477
participant stoichiometry: PARTICIPANT STOICHIOMETRY r134 476
participant stoichiometry: PARTICIPANT STOICHIOMETRY r134 478
left: PS
left: APC
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PS/APC)

uniprot Q02445 92
type: UnificationXref
id: Q02445
db: uniprot

uniprot P70375 185
type: UnificationXref
id: P70375
db: uniprot

uniprot F1PRU9 60
type: UnificationXref
id: F1PRU9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NXV6 84
xref: PTHR24254:SF10
organism: Gallus gallus

uniprot H2QR41 12
type: UnificationXref
id: H2QR41
db: uniprot

Alpha-2-macroglobulin
type: ProteinReference
xref: uniprot P06238 129
xref: PTHR11412:SF150
organism: Rattus norvegicus

uniprot F1PUI4 65
type: UnificationXref
id: F1PUI4
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 15

uPAR
type: Protein
entity reference: uPAR
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa8 252
comment: SPECIES_TYPE=PROTEIN

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Plasmin-RIGHT__Plasmin-_re69
controller: alpha2-antiplasmin

HETERODIMER_ASSOCIATION_LEFT__PS-_APC-RIGHT__Complex__PS_APC_-_r140
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r140 451
participant stoichiometry: PARTICIPANT STOICHIOMETRY r140 452
participant stoichiometry: PARTICIPANT STOICHIOMETRY r140 450
left: PS
left: APC
interaction type: HETERODIMER_ASSOCIATION
right: Complex (PS/APC)

PTHR23103:SF7
type: RelationshipXref
id: PTHR23103:SF7
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Complex__GP_V_GP_IX_-_GP_1bbeta-RIGHT__Complex__GP_IX_GP_1bbeta__GP_Ibalpha_GP_V_-_r144
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r144 438
participant stoichiometry: PARTICIPANT STOICHIOMETRY r144 436
participant stoichiometry: PARTICIPANT STOICHIOMETRY r144 437
left: GP 1bbeta
left: Complex (GP V/GP IX)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GP IX/GP 1bbeta/ GP Ibalpha/GP V)

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Thrombin
type: Protein
entity reference: Thrombin
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

INHIBITION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re70 449
type: Stoichiometry
physical entity: Thrombin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re70 448
type: Stoichiometry
physical entity: Thrombin
stoichiometric coefficient: 1.0

uniprot E1BWG1 95
type: UnificationXref
id: E1BWG1
db: uniprot

Prothrombin
type: ProteinReference
xref: uniprot H2Q3I2 85
xref: PTHR24254:SF10
organism: Pan troglodytes

DISSOCIATION_LEFT__Complex__FIXa_Ca2_PLUS___FVIIIa_PL_-RIGHT__FVIIIa-_FIXa-_r166
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r166 474
participant stoichiometry: PARTICIPANT STOICHIOMETRY r166 473
participant stoichiometry: PARTICIPANT STOICHIOMETRY r166 475
left: Complex (FIXa/Ca2+/ FVIIIa/PL)
interaction type: DISSOCIATION
right: FVIIIa
right: FIXa

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa180 296
comment: SPECIES_TYPE=ION

PAR-4
type: ProteinReference
xref: P00461
standard name: Protease-activated receptor4
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.PAR-4
comment: ENTITY_REFERENCE_NOTES=Long Name: Protease-activated receptor4 Synonym: PAR-4,coagulation factor II receptor-like 3,thrombin receptor-like 3 Accession: P00461
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Proteinase-activated receptor 4
member entity reference: F2R like thrombin or trypsin receptor 3

Vitamin K-dependent protein S
type: ProteinReference
xref: PTHR24040:SF0
xref: uniprot P07224 72
organism: Bos taurus

Vitamin K-dependent protein S
type: ProteinReference
xref: PTHR24040:SF0
xref: uniprot P07225 74
organism: Homo sapiens

Thrombin
type: Protein
entity reference: Thrombin
comment: SPECIES_TYPE=PROTEIN

Platelet glycoprotein Ib beta chain
type: ProteinReference
xref: PTHR22650:SF7
xref: uniprot P56400 164
organism: Mus musculus

Plasminogen activator inhibitor 1
type: ProteinReference
xref: PTHR11461:SF49
xref: uniprot P22777 70
organism: Mus musculus

HMWK s23 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HMWK
stoichiometric coefficient: 1.0

Plasma kallikrein
type: ProteinReference
xref: uniprot P14272 168
xref: PTHR24253:SF64
organism: Rattus norvegicus

GP IIIa
type: Protein
entity reference: GP IIIa
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa18 248
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

Integrin beta
type: ProteinReference
xref: PTHR10082:SF25
xref: uniprot F1PPG5 214
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re73 439
type: Stoichiometry
physical entity: Complex (FVIIa/Tissue Factor/ PL/Ca2+)
stoichiometric coefficient: 1.0

Urokinase-type plasminogen activator
type: ProteinReference
xref: uniprot P06869 156
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__FXa_FVa__Ca2_PLUS__PL_-RIGHT__FVa-_FXa-_r165
controller: Complex (PS/APC)

STATE_TRANSITION_LEFT__Complex__FVIIa_Tissue_Factor__PL_Ca2_PLUS__-RIGHT__Complex__FVIIa_Tissue_Factor__PL_Ca2_PLUS__-_re73
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re73 439
participant stoichiometry: PARTICIPANT STOICHIOMETRY re73 440
left: Complex (FVIIa/Tissue Factor/ PL/Ca2+)
interaction type: STATE_TRANSITION
right: Complex (FVIIa/Tissue Factor/ PL/Ca2+)

uniprot H2QV47 67
type: UnificationXref
id: H2QV47
db: uniprot

Serpin family A member 10
type: ProteinReference
xref: uniprot H2Q8V0 126
xref: PTHR11461:SF191
organism: Pan troglodytes

TRUNCATION
type: InteractionVocabulary

Protein Z-dependent protease inhibitor
type: ProteinReference
xref: uniprot Q9UK55 128
xref: PTHR11461:SF191
organism: Homo sapiens

Prothrombin
type: ProteinReference
xref: P00416
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.Prothrombin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Prothrombin Synonym: Factor II Accession: P00416
member entity reference: Prothrombin
member entity reference: Uncharacterized protein

UNKNOWN_TRANSITION_LEFT__Fibrinogen-RIGHT__Fibrin_monomer-_r162
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r162 497
participant stoichiometry: PARTICIPANT STOICHIOMETRY r162 498
left: Fibrinogen
interaction type: UNKNOWN_TRANSITION
right: Fibrin monomer

Fibrinogen beta chain
type: ProteinReference
xref: PTHR19143:SF332
xref: uniprot P14480 42
organism: Rattus norvegicus

Urokinase plasminogen activator surface receptor
type: ProteinReference
xref: PTHR10624:SF6
xref: uniprot P35456 157
organism: Mus musculus

Coagulation factor XIII A chain
type: ProteinReference
xref: PTHR11590:SF42
xref: uniprot E1BWG1 95
organism: Gallus gallus

HMWK
type: ProteinReference
xref: P00413
standard name: High molecular weight kininogen
comment: ENTITY_REFERENCE_NOTES=Long Name: High molecular weight kininogen Synonym: Fitzgerald, Flaujeac Williams factor,HMWK,contact activation cofactor,plasma thromboplastin antecedent Accession: P00413
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.HMWK
member entity reference: KNG1 isoform 2
member entity reference: Kininogen-1
member entity reference: Uncharacterized protein
member entity reference: Kininogen-2

uniprot P13726 195
type: UnificationXref
id: P13726
db: uniprot

PARTICIPANT STOICHIOMETRY re73 440
type: Stoichiometry
physical entity: Complex (FVIIa/Tissue Factor/ PL/Ca2+)
stoichiometric coefficient: 1.0

Proteinase-activated receptor 1
type: ProteinReference
xref: PTHR24232:SF20
xref: uniprot P26824 14
organism: Rattus norvegicus

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: activated platelet response
controller: PAR-4

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QMC6 20
xref: PTHR24543:SF310
organism: Macaca mulatta

IDA
type: EvidenceCodeVocabulary

PTHR19143:SF232
type: RelationshipXref
id: PTHR19143:SF232
db: PANTHER Family
relationship type: By Homology

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s106 sa68 366
comment: SPECIES_TYPE=ION

uniprot F7FG54 216
type: UnificationXref
id: F7FG54
db: uniprot

uniprot P20961 69
type: UnificationXref
id: P20961
db: uniprot

DISSOCIATION_LEFT__Complex__PC_EPCR_-RIGHT__EPCR-_APC-_r132
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r132 486
participant stoichiometry: PARTICIPANT STOICHIOMETRY r132 487
participant stoichiometry: PARTICIPANT STOICHIOMETRY r132 488
left: Complex (PC/EPCR)
interaction type: DISSOCIATION
right: APC
right: EPCR

Fibrinogen
type: Protein
entity reference: Fibrinogen
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa21 324
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

Complex (GP IIIa/GP IIb/ Fibrinogen)
type: Complex
component stoichiometry: Fibrinogen s34 sa21 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP IIIa s32 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP IIb s33 sa20 STOICHIOMETRY ID COMPLEX
component: Fibrinogen
component: GP IIb
component: GP IIIa
feature: COMPLEX BINDING FEATURE s131 a196 321
feature: COMPLEX BINDING FEATURE s131 a196 319
feature: COMPLEX BINDING FEATURE s131 a196 323
cellular location: activated platelet c1

uniprot P33587 119
type: UnificationXref
id: P33587
db: uniprot

uniprot P19540 114
type: UnificationXref
id: P19540
db: uniprot

PS
type: Protein
entity reference: PS
comment: SPECIES_TYPE=PROTEIN

Complex (GP 1bbeta/GP Ibalpha)
type: Complex
component stoichiometry: GP 1bbeta s13 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: GP Ibalpha s14 sa10 STOICHIOMETRY ID COMPLEX
component: GP Ibalpha
component: GP 1bbeta
feature: COMPLEX BINDING FEATURE s115 a171 259
feature: COMPLEX BINDING FEATURE s115 a171 261
cellular location: activated platelet c1

uniprot Q28864 93
type: UnificationXref
id: Q28864
db: uniprot

F2R like thrombin or trypsin receptor 3
type: ProteinReference
xref: PTHR24232:SF22
xref: uniprot H2R6B3 220
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Plasminogen-RIGHT__Plasmin-_?-_r164
controller: tPA

PLAU isoform 1
type: ProteinReference
xref: uniprot K7CJD2 121
xref: PTHR24264:SF38
organism: Pan troglodytes

uniprot P05120 56
type: UnificationXref
id: P05120
db: uniprot

uniprot P12023 147
type: UnificationXref
id: P12023
db: uniprot

uniprot F6TWU5 54
type: UnificationXref
id: F6TWU5
db: uniprot

Coagulation factor XIII B chain
type: ProteinReference
xref: uniprot H2Q0U3 97
xref: PTHR45785:SF3
organism: Pan troglodytes

uniprot P00734 86
type: UnificationXref
id: P00734
db: uniprot

vWF
type: Protein
entity reference: vWF
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR11461:SF49
xref: uniprot F6Y5D7 66
organism: Macaca mulatta

PL
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa28 276
comment: SPECIES_TYPE=SIMPLE_MOLECULE

?
type: Protein
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__HMWK-_Kallikrein-RIGHT__Complex__Kallikrein_HMWK_-_r112
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 433
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 435
participant stoichiometry: PARTICIPANT STOICHIOMETRY r112 434
left: Kallikrein
left: HMWK
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Kallikrein/HMWK)

FGB isoform 1
type: ProteinReference
xref: uniprot H2QQB4 33
xref: PTHR19143:SF332
organism: Pan troglodytes

FGA isoform 1
type: ProteinReference
xref: PTHR47221:SF1
xref: uniprot H2QQB5 34
organism: Pan troglodytes

Zn2 PLUS s78 sa176 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Zn2+
stoichiometric coefficient: 1.0

uniprot O08770 103
type: UnificationXref
id: O08770
db: uniprot

GP Ibalpha s118 sa78 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP Ibalpha
stoichiometric coefficient: 1.0

uniprot G1K2B9 188
type: UnificationXref
id: G1K2B9
db: uniprot

PTHR11461:SF53
type: RelationshipXref
id: PTHR11461:SF53
db: PANTHER Family
relationship type: By Homology

GP V s112 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP V
stoichiometric coefficient: 1.0

uniprot Q2F9P2 186
type: UnificationXref
id: Q2F9P2
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Thrombin-RIGHT__Thrombin-_re70
control type: ACTIVATION
controller: alpha1-antitrypsin

HETERODIMER_ASSOCIATION_LEFT__FV-_FXa-RIGHT__Complex__FXa_FVa__Ca2_PLUS__PL_-_r130
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r130 496
participant stoichiometry: PARTICIPANT STOICHIOMETRY r130 494
participant stoichiometry: PARTICIPANT STOICHIOMETRY r130 495
left: FXa
left: FV
interaction type: HETERODIMER_ASSOCIATION
right: Complex (FXa/FVa/ Ca2+/PL)

Prothrombin
type: Protein
entity reference: Prothrombin
comment: SPECIES_TYPE=PROTEIN

PTHR11412:SF116
type: RelationshipXref
id: PTHR11412:SF116
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Complex__Tissue_Factor_FVIIa__PL_Ca2_PLUS___FXa_-_TFPI-RIGHT__Complex__TFPI_Tissue_Factor__FVIIa_FXa__PL_Ca2_PLUS__-_r128
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r128 386
participant stoichiometry: PARTICIPANT STOICHIOMETRY r128 387
participant stoichiometry: PARTICIPANT STOICHIOMETRY r128 385
left: TFPI
left: Complex (Tissue Factor/FVIIa/ PL/Ca2+/ FXa)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (TFPI/Tissue Factor/ FVIIa/FXa/ PL/Ca2+)

GP IIIa
type: Protein
entity reference: GP IIIa
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa19 320
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__FIX-RIGHT__FIXa-_?-_r157
controller: FXIa

PARTICIPANT STOICHIOMETRY re71 444
type: Stoichiometry
physical entity: FXIa
stoichiometric coefficient: 1.0

PL
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa40 334
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re71 443
type: Stoichiometry
physical entity: FXIa
stoichiometric coefficient: 1.0

activated platelet response
type: Pathway

uniprot H2Q3I2 85
type: UnificationXref
id: H2Q3I2
db: uniprot

Fibrinogen beta chain
type: ProteinReference
xref: uniprot F1NUL9 30
organism: Gallus gallus

Integrin subunit alpha 2b
type: ProteinReference
xref: uniprot D3ZAC0 59
xref: PTHR23220:SF73
organism: Rattus norvegicus

PTHR11461:SF49
type: RelationshipXref
id: PTHR11461:SF49
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PLZ2 205
xref: PTHR11461:SF30
organism: Gallus gallus

FIXa
type: Protein
entity reference: FIXa
feature: COMPLEX PARTICIPANT BINDING FEATURE s105 sa67 364
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__FX-RIGHT__FXa-_?-_r159
controller: Complex (FIXa/Ca2+/ FVIIIa/PL)

Plasminogen
type: ProteinReference
xref: PTHR24261:SF13
xref: uniprot E1B726 48
organism: Bos taurus

activated platelet c1
type: CellularLocationVocabulary
comment: activated platelet

uniprot P03952 167
type: UnificationXref
id: P03952
db: uniprot

uniprot Q91Y47 161
type: UnificationXref
id: Q91Y47
db: uniprot

PANTHER Pathway P00011 1
type: UnificationXref
id: P00011
db: PANTHER Pathway

PARTICIPANT STOICHIOMETRY r41 423
type: Stoichiometry
physical entity: a52_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 422
type: Stoichiometry
physical entity: Fibrin polymer cross-linked
stoichiometric coefficient: 1.0

FVIIIa
type: Protein
entity reference: FVIIIa
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Complex__FVIIa_Tissue_Factor__PL_Ca2_PLUS__-RIGHT__Complex__FVIIa_Tissue_Factor__PL_Ca2_PLUS__-_re73
control type: ACTIVATION
controller: ATiii heparin complex

PTHR10624:SF6
type: RelationshipXref
id: PTHR10624:SF6
db: PANTHER Family
relationship type: By Homology

FVIIa s59 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FVIIa
stoichiometric coefficient: 1.0

PROC isoform 3
type: ProteinReference
xref: PTHR24278:SF0
xref: uniprot A0A2I3RIA9 116
organism: Pan troglodytes

uniprot B0JZ09 26
type: UnificationXref
id: B0JZ09
db: uniprot

GP 1bbeta
type: Protein
entity reference: GP 1bbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s110 sa72 342
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

Tissue factor
type: ProteinReference
xref: uniprot P42533 198
xref: PTHR20859:SF22
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r148 426
type: Stoichiometry
physical entity: PAR-1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r148 427
type: Stoichiometry
physical entity: PAR-1
stoichiometric coefficient: 1.0

uniprot A0A1D5Q7P1 150
type: UnificationXref
id: A0A1D5Q7P1
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Thrombin-RIGHT__Thrombin-_re70
control type: ACTIVATION
controller: ATiii heparin complex

PTHR11461:SF61
type: RelationshipXref
id: PTHR11461:SF61
db: PANTHER Family
relationship type: By Homology

APC
type: Protein
entity reference: APC
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

PL s82 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r158 396
type: Stoichiometry
physical entity: Complex (FVIIa/Tissue Factor/ PL/Ca2+)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r158 397
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r158 394
type: Stoichiometry
physical entity: Complex (Tissue Factor/PL/ Ca2+)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r158 395
type: Stoichiometry
physical entity: FVII
stoichiometric coefficient: 1.0

GP IIb
type: ProteinReference
xref: P00410
standard name: Glycoprotein IIb
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.GP IIb
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Integrin alpha-IIb
member entity reference: Uncharacterized protein
member entity reference: Integrin subunit alpha 2b

GP 1bbeta
type: ProteinReference
xref: P00436
standard name: Glycoprotein 1bbeta
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.GP 1b_beta_
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Platelet glycoprotein Ib beta chain
member entity reference: GP1BB isoform 1

Prekallikrein
type: Protein
entity reference: Prekallikrein
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E7I7 61
xref: PTHR23220:SF73
organism: Macaca mulatta

uniprot P31394 118
type: UnificationXref
id: P31394
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__FXIII-RIGHT__FXIIIa-_?-_r160
controller: Thrombin

GP V
type: ProteinReference
xref: P00420
standard name: Glycoprotein V
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.RECEPTOR.GP V
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Platelet glycoprotein V

STATE_TRANSITION_LEFT__uPA-RIGHT__uPA-_r90
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 454
participant stoichiometry: PARTICIPANT STOICHIOMETRY r90 453
left: uPA
interaction type: STATE_TRANSITION
right: uPA

PARTICIPANT STOICHIOMETRY r157 399
type: Stoichiometry
physical entity: FIXa
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r157 398
type: Stoichiometry
physical entity: FIX
stoichiometric coefficient: 1.0

alpha2-macroglobulin
type: Protein
entity reference: alpha2-macroglobulin
comment: SPECIES_TYPE=PROTEIN

FX
type: ProteinReference
xref: P00430
standard name: Factor X
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FX
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Factor X Synonym: Stuart-Prower Factor Accession: P00430
member entity reference: Coagulation factor X
member entity reference: Uncharacterized protein

PTHR11412:SF150
type: RelationshipXref
id: PTHR11412:SF150
db: PANTHER Family
relationship type: By Homology

Pregnancy zone protein
type: ProteinReference
xref: PTHR11412:SF116
xref: uniprot Q61838 130
organism: Mus musculus

uniprot Q01177 53
type: UnificationXref
id: Q01177
db: uniprot

uniprot Q9JJM7 165
type: UnificationXref
id: Q9JJM7
db: uniprot

uniprot Q9UNN8 10
type: UnificationXref
id: Q9UNN8
db: uniprot

Complex (FVIIa/Tissue Factor/ PL/Ca2+)
type: Complex
component stoichiometry: PL s64 sa179 STOICHIOMETRY ID COMPLEX
component stoichiometry: FVIIa s59 sa177 STOICHIOMETRY ID COMPLEX
component stoichiometry: Tissue Factor s60 sa178 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s73 sa180 STOICHIOMETRY ID COMPLEX
component: PL
component: Tissue Factor
component: Ca2+
component: FVIIa
feature: COMPLEX BINDING FEATURE s148 csa30 293
feature: COMPLEX BINDING FEATURE s148 csa30 291
feature: COMPLEX BINDING FEATURE s148 csa30 289
feature: COMPLEX BINDING FEATURE s148 csa30 295

Heparin cofactor 2
type: ProteinReference
xref: uniprot Q64268 208
xref: PTHR11461:SF30
organism: Rattus norvegicus

FVa
type: Protein
entity reference: FVa
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa50 374
comment: SPECIES_TYPE=PROTEIN

Tissue factor pathway inhibitor
type: ProteinReference
xref: uniprot P10646 91
xref: PTHR10083:SF328
organism: Homo sapiens

Tissue-type plasminogen activator
type: ProteinReference
xref: uniprot P19637 155
xref: PTHR24264:SF42
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__tPA-RIGHT__tPA-_r87
controller: FXa

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 27

uniprot F7CC91 49
type: UnificationXref
id: F7CC91
db: uniprot

Integrin subunit alpha 2b
type: ProteinReference
xref: PTHR23220:SF73
xref: uniprot H2QD72 62
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR13814:SF12
xref: uniprot F6SG43 78
organism: Macaca mulatta

Endothelial protein C receptor
type: ProteinReference
xref: uniprot Q64695 8
xref: PTHR15349:SF0
organism: Mus musculus

Coagulation factor XIII B chain
type: ProteinReference
xref: PTHR45785:SF3
xref: uniprot Q07968 100
organism: Mus musculus

FXIa
type: ProteinReference
xref: P00434
standard name: Factor Xia
comment: ENTITY_REFERENCE_NOTES=Long Name: FXIa Synonym: plasma thromboplastin antecedent Accession: P00434
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FXIa
member entity reference: Coagulation factor XI
member entity reference: Coagulation factor IX
member entity reference: Uncharacterized protein

PL s55 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PL
stoichiometric coefficient: 1.0

PL
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s94 sa52 378
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PC-RIGHT__APC-_r133
controller: Complex (Thrombomodulin/Thrombin/ Ca2+/PL)

Tissue Factor
type: Protein
entity reference: Tissue Factor
feature: COMPLEX PARTICIPANT BINDING FEATURE s75 sa38 330
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__FXIa-RIGHT__FXIa-_re71
control type: ACTIVATION
controller: PN2

Fibrin monomer
type: Protein
entity reference: Fibrin monomer
comment: SPECIES_TYPE=PROTEIN

uniprot P01042 80
type: UnificationXref
id: P01042
db: uniprot

uniprot P00741 112
type: UnificationXref
id: P00741
db: uniprot

uniprot Q03405 158
type: UnificationXref
id: Q03405
db: uniprot

PTHR10083:SF328
type: RelationshipXref
id: PTHR10083:SF328
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r145 432
type: Stoichiometry
physical entity: Complex (GP IX/GP V/ GP 1bbeta/GP Ibalpha/ vWF)
stoichiometric coefficient: 1.0

Complex (PC/EPCR)
type: Complex
component stoichiometry: PC s18 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: EPCR s21 sa14 STOICHIOMETRY ID COMPLEX
component: EPCR
component: PC
feature: COMPLEX BINDING FEATURE s120 a177 361
feature: COMPLEX BINDING FEATURE s120 a177 359

PARTICIPANT STOICHIOMETRY r145 431
type: Stoichiometry
physical entity: vWF
stoichiometric coefficient: 1.0

uniprot F1NXV6 84
type: UnificationXref
id: F1NXV6
db: uniprot

PARTICIPANT STOICHIOMETRY r145 430
type: Stoichiometry
physical entity: Complex (GP IX/GP 1bbeta/ GP Ibalpha/GP V)
stoichiometric coefficient: 1.0

uniprot P14272 168
type: UnificationXref
id: P14272
db: uniprot

Heparin cofactor 2
type: ProteinReference
xref: uniprot P49182 207
xref: PTHR11461:SF30
organism: Mus musculus

Fibrinogen alpha chain
type: ProteinReference
xref: uniprot P14448 41
xref: PTHR19143:SF232
organism: Gallus gallus

uniprot H2Q0U3 97
type: UnificationXref
id: H2Q0U3
db: uniprot

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa33 258
comment: SPECIES_TYPE=ION

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PAR_4-RIGHT__PAR_4-_r149
controller: Thrombin

uniprot Q9UK55 128
type: UnificationXref
id: Q9UK55
db: uniprot

ncbitaxon 9913 7
type: UnificationXref
id: 9913
db: ncbitaxon

tPA
type: ProteinReference
xref: P00431
standard name: Tissue plasminogen activator
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.tPA
comment: ENTITY_REFERENCE_NOTES=Long Name: Tissue plasminogen activator Synonym: tPA Accession: P00431
member entity reference: Tissue-type plasminogen activator
member entity reference: Plasminogen activator
member entity reference: Plasminogen activator, tissue type

GP IX
type: Protein
entity reference: GP IX
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa12 382
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

uniprot H2R022 194
type: UnificationXref
id: H2R022
db: uniprot

CATALYSIS
type: Catalysis
controlled: UNKNOWN_TRANSITION_LEFT__Fibrin_monomer-RIGHT__Fibrin_polymer_cross_linked-_r163
controller: FXIIIa

Fibrinogen beta chain
type: ProteinReference
xref: PTHR19143:SF332
xref: uniprot Q8K0E8 43
organism: Mus musculus

FVa s92 sa50 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FVa
stoichiometric coefficient: 1.0

uniprot H2QK24 209
type: UnificationXref
id: H2QK24
db: uniprot

Tissue-type plasminogen activator
type: ProteinReference
xref: PTHR24264:SF42
xref: uniprot P11214 154
organism: Mus musculus

PTHR13814:SF12
type: RelationshipXref
id: PTHR13814:SF12
db: PANTHER Family
relationship type: By Homology

Kallikrein
type: Protein
entity reference: Kallikrein
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__FX-RIGHT__FXa-_?-_r159
controller: Complex (FVIIa/Tissue Factor/ PL/Ca2+)

TRUNCATION
type: RelationshipTypeVocabulary

Serpin family E member 1
type: ProteinReference
xref: uniprot A0A452DIJ9 64
xref: PTHR11461:SF49
organism: Bos taurus

Complex (uPA/uPAR)
type: Complex
component stoichiometry: uPA s11 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: uPAR s12 sa8 STOICHIOMETRY ID COMPLEX
component: uPAR
component: uPA
feature: COMPLEX BINDING FEATURE s101 a152 251
feature: COMPLEX BINDING FEATURE s101 a152 249
feature: ACTIVE 17

ncbitaxon 9598 3
type: UnificationXref
id: 9598
db: ncbitaxon

PL s104 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r140 450
type: Stoichiometry
physical entity: PS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r140 451
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

uniprot P06399 39
type: UnificationXref
id: P06399
db: uniprot

PARTICIPANT STOICHIOMETRY r140 452
type: Stoichiometry
physical entity: Complex (PS/APC)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR19143:SF332
xref: uniprot F6UZ87 32
organism: Macaca mulatta

uniprot F7F6Y0 125
type: UnificationXref
id: F7F6Y0
db: uniprot

uniprot A0A452DIJ9 64
type: UnificationXref
id: A0A452DIJ9
db: uniprot

HMWK
type: Protein
entity reference: HMWK
comment: SPECIES_TYPE=PROTEIN

SERPINE1 isoform 1
type: ProteinReference
xref: uniprot H2QV47 67
xref: PTHR11461:SF49
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: activated platelet response
controller: Complex (GP IIIa/GP IIb/ Fibrinogen)

Integrin subunit alpha 2b
type: ProteinReference
xref: uniprot F1PRU9 60
xref: PTHR23220:SF73
organism: Canis lupus familiaris

Plasminogen activator inhibitor 1
type: ProteinReference
xref: uniprot P20961 69
xref: PTHR11461:SF49
organism: Rattus norvegicus

FVII
type: Protein
entity reference: FVII
comment: SPECIES_TYPE=PROTEIN

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s102 sa65 238
comment: SPECIES_TYPE=ION

Fibrinogen gamma-B chain
type: ProteinReference
xref: PTHR19143:SF338
xref: uniprot P12799 40
organism: Bos taurus

vWF s50 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: vWF
stoichiometric coefficient: 1.0

PTHR24036:SF5
type: RelationshipXref
id: PTHR24036:SF5
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9606 11
type: UnificationXref
id: 9606
db: ncbitaxon

Thrombomodulin
type: ProteinReference
xref: PTHR24036:SF5
xref: uniprot H2QK24 209
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r162 498
type: Stoichiometry
physical entity: Fibrin monomer
stoichiometric coefficient: 1.0

Proteinase-activated receptor 4
type: ProteinReference
xref: PTHR24232:SF22
xref: uniprot Q96RI0 222
organism: Homo sapiens

Bos taurus
type: BioSource
xref: ncbitaxon 9913 7

FXI
type: Protein
entity reference: FXI
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa6 304
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PC-RIGHT__APC-_r133
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r133 484
participant stoichiometry: PARTICIPANT STOICHIOMETRY r133 485
left: PC
interaction type: STATE_TRANSITION
right: APC

UNKNOWN_TRANSITION
type: InteractionVocabulary

Tissue factor
type: ProteinReference
xref: uniprot H2R022 194
xref: PTHR20859:SF22
organism: Pan troglodytes

STATE_TRANSITION_LEFT__mPAR_3-RIGHT__mPAR_3-_r147
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r147 429
participant stoichiometry: PARTICIPANT STOICHIOMETRY r147 428
left: mPAR-3
interaction type: STATE_TRANSITION
right: mPAR-3

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 139

UNKNOWN_TRANSITION_LEFT__Fibrin_monomer-RIGHT__Fibrin_polymer_cross_linked-_r163
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r163 492
participant stoichiometry: PARTICIPANT STOICHIOMETRY r163 493
left: Fibrin monomer
interaction type: UNKNOWN_TRANSITION
right: Fibrin polymer cross-linked

PN2
type: Protein
entity reference: PN2
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r162 497
type: Stoichiometry
physical entity: Fibrinogen
stoichiometric coefficient: 1.0

uniprot Q8R121 127
type: UnificationXref
id: Q8R121
db: uniprot

Coagulation factor II (Thrombin) receptor
type: ProteinReference
xref: uniprot H2QR41 12
xref: PTHR24232:SF20
organism: Pan troglodytes

Complex (ZPI/PZ/ FXa/Ca2+/ PL)
type: Complex
component stoichiometry: Ca2 PLUS s102 sa65 STOICHIOMETRY ID COMPLEX
component stoichiometry: PL s104 sa66 STOICHIOMETRY ID COMPLEX
component stoichiometry: FXa s99 sa64 STOICHIOMETRY ID COMPLEX
component stoichiometry: ZPI s97 sa62 STOICHIOMETRY ID COMPLEX
component stoichiometry: PZ s98 sa63 STOICHIOMETRY ID COMPLEX
component: FXa
component: Ca2+
component: PL
component: ZPI
component: PZ
feature: COMPLEX BINDING FEATURE s180 a292 231
feature: COMPLEX BINDING FEATURE s180 a292 239
feature: COMPLEX BINDING FEATURE s180 a292 237
feature: COMPLEX BINDING FEATURE s180 a292 233
feature: COMPLEX BINDING FEATURE s180 a292 235

STATE_TRANSITION_LEFT__Thrombin-RIGHT__Thrombin-_re70
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re70 449
participant stoichiometry: PARTICIPANT STOICHIOMETRY re70 448
left: Thrombin
interaction type: STATE_TRANSITION
right: Thrombin

uniprot E2RES2 170
type: UnificationXref
id: E2RES2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GHR4 110
xref: PTHR24278:SF31
organism: Macaca mulatta

uniprot F7FYL8 138
type: UnificationXref
id: F7FYL8
db: uniprot

Plasminogen activator inhibitor 2, macrophage
type: ProteinReference
xref: PTHR11461:SF61
xref: uniprot P12388 57
organism: Mus musculus

uniprot H2R1R6 22
type: UnificationXref
id: H2R1R6
db: uniprot

uniprot K7CJD2 121
type: UnificationXref
id: K7CJD2
db: uniprot

Kallikrein
type: Protein
entity reference: Kallikrein
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa15 316
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

uniprot P32261 174
type: UnificationXref
id: P32261
db: uniprot

Tissue factor
type: ProteinReference
xref: PTHR20859:SF22
xref: uniprot P20352 196
organism: Mus musculus

PTHR24543:SF302
type: RelationshipXref
id: PTHR24543:SF302
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__FXII-_Zn2_PLUS_-RIGHT__FXIIa_Zn2_PLUS__complex-_?-_r153
controller: Kallikrein

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__mPAR_3-RIGHT__mPAR_3-_r147
controller: Thrombin

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__tPA-RIGHT__tPA-_r87
control type: INHIBITION
controller: PAI-2

Kininogen-2
type: ProteinReference
xref: uniprot P01045 81
xref: PTHR13814:SF12
organism: Bos taurus

uniprot A0A0G2K4I9 160
type: UnificationXref
id: A0A0G2K4I9
db: uniprot

uniprot O88947 141
type: UnificationXref
id: O88947
db: uniprot

PL
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s104 sa66 240
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Kininogen-1
type: ProteinReference
xref: uniprot P01042 80
xref: PTHR13814:SF12
organism: Homo sapiens

uniprot H2RCB6 162
type: UnificationXref
id: H2RCB6
db: uniprot

PAI-1
type: Protein
entity reference: PAI-1
comment: SPECIES_TYPE=PROTEIN

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 19

BOOLEAN_LOGIC_GATE_OR
type: RelationshipTypeVocabulary

uniprot F1PFS7 18
type: UnificationXref
id: F1PFS7
db: uniprot

FXIa
type: Protein
entity reference: FXIa
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

Plasminogen activator
type: ProteinReference
xref: uniprot A0A1D5Q7P1 150
xref: PTHR24264:SF42
organism: Macaca mulatta

uniprot Q96RI0 222
type: UnificationXref
id: Q96RI0
db: uniprot

PTHR24543:SF310
type: RelationshipXref
id: PTHR24543:SF310
db: PANTHER Family
relationship type: By Homology

uniprot E1C440 144
type: UnificationXref
id: E1C440
db: uniprot

uniprot P26824 14
type: UnificationXref
id: P26824
db: uniprot

PTHR22650:SF6
type: RelationshipXref
id: PTHR22650:SF6
db: PANTHER Family
relationship type: By Homology

PTHR22650:SF7
type: RelationshipXref
id: PTHR22650:SF7
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FV-RIGHT__FV-_r129
controller: Thrombin

uniprot P19221 89
type: UnificationXref
id: P19221
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 29

PTHR10082:SF25
type: RelationshipXref
id: PTHR10082:SF25
db: PANTHER Family
relationship type: By Homology

TRUNCATION_LEFT__Prekallikrein-RIGHT__Kallikrein-_?-_r152
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r152 419
participant stoichiometry: PARTICIPANT STOICHIOMETRY r152 420
participant stoichiometry: PARTICIPANT STOICHIOMETRY r152 421
left: Prekallikrein
interaction type: TRUNCATION
right: Kallikrein
right: ?

Ca2 PLUS s48 sa27 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Plasminogen
type: ProteinReference
xref: PTHR24261:SF13
xref: uniprot P20918 52
organism: Mus musculus

uniprot F6Y0N9 171
type: UnificationXref
id: F6Y0N9
db: uniprot

GP V
type: Protein
entity reference: GP V
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa11 380
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

uniprot P08934 82
type: UnificationXref
id: P08934
db: uniprot

uniprot P00748 179
type: UnificationXref
id: P00748
db: uniprot

Thrombomodulin s39 sa22 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Thrombomodulin
stoichiometric coefficient: 1.0

Zn2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa176 230
comment: SPECIES_TYPE=ION

uniprot A0A2I3T2M5 25
type: UnificationXref
id: A0A2I3T2M5
db: uniprot

uniprot P41361 175
type: UnificationXref
id: P41361
db: uniprot

GP IX s113 sa75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP IX
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__FXIa-RIGHT__FXIa-_re71
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re71 444
participant stoichiometry: PARTICIPANT STOICHIOMETRY re71 443
left: FXIa
interaction type: STATE_TRANSITION
right: FXIa

uniprot A0A452DIP8 136
type: UnificationXref
id: A0A452DIP8
db: uniprot

PZ
type: ProteinReference
xref: P00407
standard name: Protein Z
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.PZ
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Vitamin K-dependent protein Z
member entity reference: PROZ isoform 2

PARTICIPANT STOICHIOMETRY r134 476
type: Stoichiometry
physical entity: PS
stoichiometric coefficient: 1.0

Coagulation factor X
type: ProteinReference
xref: PTHR24278:SF28
xref: uniprot A0A452DIP8 136
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r134 477
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r134 478
type: Stoichiometry
physical entity: Complex (PS/APC)
stoichiometric coefficient: 1.0

Ca2 PLUS s73 sa180 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Glycoprotein 9
type: ProteinReference
xref: PTHR22650:SF6
xref: uniprot Q4AEG0 204
organism: Rattus norvegicus

uniprot P00740 111
type: UnificationXref
id: P00740
db: uniprot

ATiii heparin complex
type: Complex
component stoichiometry: ATIII s203 sa172 STOICHIOMETRY ID COMPLEX
component stoichiometry: Heparan s202 sa173 STOICHIOMETRY ID COMPLEX
component: ATIII
component: Heparan
feature: COMPLEX BINDING FEATURE s201 csa28 277
feature: COMPLEX BINDING FEATURE s201 csa28 279

Fgb protein
type: ProteinReference
xref: uniprot B0JZ09 26
xref: PTHR19143:SF332
organism: Xenopus tropicalis

TRUNCATION_LEFT__FXII-_Zn2_PLUS_-RIGHT__FXIIa_Zn2_PLUS__complex-_?-_r153
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r153 416
participant stoichiometry: PARTICIPANT STOICHIOMETRY r153 415
participant stoichiometry: PARTICIPANT STOICHIOMETRY r153 418
participant stoichiometry: PARTICIPANT STOICHIOMETRY r153 417
left: FXII
left: Zn2+
interaction type: TRUNCATION
right: FXIIa Zn2+ complex
right: ?

Tissue Factor s86 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Tissue Factor
stoichiometric coefficient: 1.0

TRUNCATION_LEFT__Complex__HMWK_FXI_-RIGHT__FXIa-_HMWK-_?-_r154
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r154 412
participant stoichiometry: PARTICIPANT STOICHIOMETRY r154 414
participant stoichiometry: PARTICIPANT STOICHIOMETRY r154 411
participant stoichiometry: PARTICIPANT STOICHIOMETRY r154 413
left: Complex (HMWK/FXI)
interaction type: TRUNCATION
right: FXIa
right: HMWK
right: ?

Ca2 PLUS s102 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24253:SF64
xref: uniprot A0A1D5Q7U7 166
organism: Macaca mulatta

uniprot A0A1D5PLZ2 205
type: UnificationXref
id: A0A1D5PLZ2
db: uniprot

Tissue factor pathway inhibitor
type: ProteinReference
xref: uniprot Q28874 94
xref: PTHR10083:SF328
organism: Canis lupus familiaris

Coagulation factor X
type: ProteinReference
xref: PTHR24278:SF28
xref: uniprot O88947 141
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r166 473
type: Stoichiometry
physical entity: Complex (FIXa/Ca2+/ FVIIIa/PL)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r166 474
type: Stoichiometry
physical entity: FVIIIa
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: UNKNOWN_TRANSITION_LEFT__Fibrinogen-RIGHT__Fibrin_monomer-_r162
controller: Thrombin

PARTICIPANT STOICHIOMETRY r166 475
type: Stoichiometry
physical entity: FIXa
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r128 387
type: Stoichiometry
physical entity: Complex (TFPI/Tissue Factor/ FVIIa/FXa/ PL/Ca2+)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r128 386
type: Stoichiometry
physical entity: TFPI
stoichiometric coefficient: 1.0

FVIIIa
type: Protein
entity reference: FVIIIa
feature: ACTIVE 17
comment: SPECIES_TYPE=PROTEIN

uPA
type: Protein
entity reference: uPA
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa7 250
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r153 415
type: Stoichiometry
physical entity: FXII
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r153 418
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r153 416
type: Stoichiometry
physical entity: Zn2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r153 417
type: Stoichiometry
physical entity: FXIIa Zn2+ complex
stoichiometric coefficient: 1.0

PTHR11461:SF30
type: RelationshipXref
id: PTHR11461:SF30
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r128 385
type: Stoichiometry
physical entity: Complex (Tissue Factor/FVIIa/ PL/Ca2+/ FXa)
stoichiometric coefficient: 1.0

Plasminogen activator inhibitor 2 type A
type: ProteinReference
xref: PTHR11461:SF61
xref: uniprot P29524 58
organism: Rattus norvegicus

FVIIa
type: ProteinReference
xref: P00447
standard name: Factor VIIa
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FVIIa
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Coagulation factor VII

Tissue factor pathway inhibitor
type: ProteinReference
xref: uniprot Q28864 93
xref: PTHR10083:SF328
organism: Macaca mulatta

FXa
type: ProteinReference
xref: P00445
standard name: Factor Xa
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FXa
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Factor Xa Synonym: Stuart-Prower Factor Accession: P00445
member entity reference: Coagulation factor X
member entity reference: Uncharacterized protein

Fibrinogen
type: ProteinReference
xref: P00406
comment: ENTITY_REFERENCE_NOTES=Long Name: Fibrinogen Synonym: Factor I Accession: P00406
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.Fibrinogen
member entity reference: Fibrinogen beta chain
member entity reference: Fibrinogen alpha chain
member entity reference: FGG isoform 5
member entity reference: FGB isoform 1
member entity reference: Uncharacterized protein
member entity reference: Fibrinogen gamma chain
member entity reference: FGA isoform 1
member entity reference: Fgb protein
member entity reference: Fibrinogen gamma-B chain

GP IIb s24 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP IIb
stoichiometric coefficient: 1.0

uniprot F7E7I7 61
type: UnificationXref
id: F7E7I7
db: uniprot

FVIIIa s107 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FVIIIa
stoichiometric coefficient: 1.0

PTHR11461:SF20
type: RelationshipXref
id: PTHR11461:SF20
db: PANTHER Family
relationship type: By Homology

uniprot P20918 52
type: UnificationXref
id: P20918
db: uniprot

uniprot P06238 129
type: UnificationXref
id: P06238
db: uniprot

FXI s10 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FXI
stoichiometric coefficient: 1.0

uniprot Q64268 208
type: UnificationXref
id: Q64268
db: uniprot

TRUNCATION_LEFT__Complex__Kallikrein_HMWK_-RIGHT__Bradykinin-_Kininogen-_Kallikrein-_r168
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r168 465
participant stoichiometry: PARTICIPANT STOICHIOMETRY r168 464
participant stoichiometry: PARTICIPANT STOICHIOMETRY r168 463
participant stoichiometry: PARTICIPANT STOICHIOMETRY r168 466
left: Complex (Kallikrein/HMWK)
interaction type: TRUNCATION
right: Bradykinin
right: Kininogen
right: Kallikrein

uniprot P40197 104
type: UnificationXref
id: P40197
db: uniprot

PAR-1
type: Protein
entity reference: PAR-1
feature: ACTIVE 17
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

uniprot P29524 58
type: UnificationXref
id: P29524
db: uniprot

GP9 isoform 1
type: ProteinReference
xref: uniprot H2RF34 201
organism: Pan troglodytes

Alpha-2-antiplasmin
type: ProteinReference
xref: uniprot P08697 133
xref: PTHR11461:SF20
organism: Homo sapiens

uniprot Q61247 135
type: UnificationXref
id: Q61247
db: uniprot

PTHR19143:SF338
type: RelationshipXref
id: PTHR19143:SF338
db: PANTHER Family
relationship type: By Homology

Platelet glycoprotein V
type: ProteinReference
xref: PTHR45617:SF38
xref: uniprot O08742 102
organism: Mus musculus

PC
type: Protein
entity reference: PC
comment: SPECIES_TYPE=PROTEIN

PTHR19143:SF332
type: RelationshipXref
id: PTHR19143:SF332
db: PANTHER Family
relationship type: By Homology

GP IX s17 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP IX
stoichiometric coefficient: 1.0

ZPI
type: Protein
entity reference: ZPI
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 sa62 232
comment: SPECIES_TYPE=PROTEIN

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa23 266
comment: SPECIES_TYPE=ION

PAR-4
type: Protein
entity reference: PAR-4
feature: ACTIVE 17
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

FX
type: Protein
entity reference: FX
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 8364 27
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot P20352 196
type: UnificationXref
id: P20352
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__GP_IX_GP_1bbeta__GP_Ibalpha_GP_V_-_vWF-RIGHT__Complex__GP_IX_GP_V__GP_1bbeta_GP_Ibalpha__vWF_-_r145
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r145 430
participant stoichiometry: PARTICIPANT STOICHIOMETRY r145 431
participant stoichiometry: PARTICIPANT STOICHIOMETRY r145 432
left: vWF
left: Complex (GP IX/GP 1bbeta/ GP Ibalpha/GP V)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GP IX/GP V/ GP 1bbeta/GP Ibalpha/ vWF)

PAI-2
type: Protein
entity reference: PAI-2
comment: SPECIES_TYPE=PROTEIN

uniprot P19637 155
type: UnificationXref
id: P19637
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__FVIIa_Tissue_Factor__PL_Ca2_PLUS__-_FXa-RIGHT__Complex__Tissue_Factor_FVIIa__PL_Ca2_PLUS___FXa_-_r127
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 389
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 390
participant stoichiometry: PARTICIPANT STOICHIOMETRY r127 388
left: FXa
left: Complex (FVIIa/Tissue Factor/ PL/Ca2+)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Tissue Factor/FVIIa/ PL/Ca2+/ FXa)

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: activated platelet response
controller: Complex (GP IX/GP V/ GP 1bbeta/GP Ibalpha/ vWF)

GP IIIa s32 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP IIIa
stoichiometric coefficient: 1.0

Tissue Factor
type: Protein
entity reference: Tissue Factor
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa31 254
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r135 472
type: Stoichiometry
physical entity: Complex (Thrombomodulin/Thrombin/ Ca2+/PL)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r135 470
type: Stoichiometry
physical entity: Complex (Thrombomodulin/Ca2+/ PL)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r135 471
type: Stoichiometry
physical entity: Thrombin
stoichiometric coefficient: 1.0

uniprot P14448 41
type: UnificationXref
id: P14448
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__FXIa-RIGHT__FXIa-_re71
control type: ACTIVATION
controller: ZPI

ncbitaxon 9031 29
type: UnificationXref
id: 9031
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r165 481
type: Stoichiometry
physical entity: FXa
stoichiometric coefficient: 1.0

Coagulation factor VII
type: ProteinReference
xref: PTHR24278:SF26
xref: uniprot P22457 184
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r165 480
type: Stoichiometry
physical entity: FVa
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__tPA-RIGHT__tPA-_r87
controller: Plasmin

vWF s119 sa79 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: vWF
stoichiometric coefficient: 1.0

Coagulation factor VII
type: ProteinReference
xref: PTHR24278:SF26
xref: uniprot F1QFP3 181
organism: Danio rerio

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__FXIIa_Zn2_PLUS__complex-RIGHT__FXIIa_Zn2_PLUS__complex-_re72
control type: ACTIVATION
controller: ATiii heparin complex

ncbitaxon 9544 21
type: UnificationXref
id: 9544
db: ncbitaxon

Integrin beta
type: ProteinReference
xref: PTHR10082:SF25
xref: uniprot F6SRR1 215
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XAB8 96
xref: PTHR45785:SF3
organism: Macaca mulatta

By Homology
type: RelationshipTypeVocabulary

vWF
type: Protein
entity reference: vWF
feature: COMPLEX PARTICIPANT BINDING FEATURE s119 sa79 314
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

FXa
type: Protein
entity reference: FXa
feature: COMPLEX PARTICIPANT BINDING FEATURE s88 sa46 354
comment: SPECIES_TYPE=PROTEIN

ZPI
type: Protein
entity reference: ZPI
feature: COMPLEX PARTICIPANT BINDING FEATURE s95 sa60 326
comment: SPECIES_TYPE=PROTEIN

FXa s88 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FXa
stoichiometric coefficient: 1.0

Heparan s202 sa173 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Heparan
stoichiometric coefficient: 1.0

Integrin beta
type: ProteinReference
xref: uniprot F1MTN1 213
xref: PTHR10082:SF25
organism: Bos taurus

FIX
type: Protein
entity reference: FIX
comment: SPECIES_TYPE=PROTEIN

PL s49 sa28 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PL
stoichiometric coefficient: 1.0

uniprot A0A1D5R0L5 187
type: UnificationXref
id: A0A1D5R0L5
db: uniprot

Alpha-1-antiproteinase
type: ProteinReference
xref: uniprot P17475 108
xref: PTHR11461:SF165
organism: Rattus norvegicus

FV
type: Protein
entity reference: FV
comment: SPECIES_TYPE=PROTEIN

uniprot P35456 157
type: UnificationXref
id: P35456
db: uniprot

STATE_TRANSITION_LEFT__Plasmin-RIGHT__Plasmin-_re69
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 456
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 455
left: Plasmin
interaction type: STATE_TRANSITION
right: Plasmin

PTHR11590:SF42
type: RelationshipXref
id: PTHR11590:SF42
db: PANTHER Family
relationship type: By Homology

uniprot P04070 117
type: UnificationXref
id: P04070
db: uniprot

FVIIa s87 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FVIIa
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__vWF_FVIII_-RIGHT__vWF-_FVIIIa-_?-_r156
controller: Thrombin

uniprot P98140 180
type: UnificationXref
id: P98140
db: uniprot

FGG isoform 5
type: ProteinReference
xref: PTHR19143:SF338
xref: uniprot A0A2I3T2M5 25
organism: Pan troglodytes

GP 1bbeta s13 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP 1bbeta
stoichiometric coefficient: 1.0

ncbitaxon 7955 182
type: UnificationXref
id: 7955
db: ncbitaxon

Tissue Factor
type: Protein
entity reference: Tissue Factor
feature: COMPLEX PARTICIPANT BINDING FEATURE s86 sa44 350
comment: SPECIES_TYPE=PROTEIN

GP 1bbeta
type: Protein
entity reference: GP 1bbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s117 sa77 310
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

uniprot F6UZ20 31
type: UnificationXref
id: F6UZ20
db: uniprot

Thrombomodulin
type: ProteinReference
xref: PTHR24036:SF5
xref: uniprot P15306 212
organism: Mus musculus

Urokinase-type plasminogen activator
type: ProteinReference
xref: uniprot Q05589 124
xref: PTHR24264:SF38
organism: Bos taurus

TFPI
type: Protein
entity reference: TFPI
feature: COMPLEX PARTICIPANT BINDING FEATURE s85 sa43 348
comment: SPECIES_TYPE=PROTEIN

FVIIa
type: Protein
entity reference: FVIIa
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa177 290
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__FIXa-_FVIIIa-RIGHT__Complex__FIXa_Ca2_PLUS___FVIIIa_PL_-_r141
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r141 447
participant stoichiometry: PARTICIPANT STOICHIOMETRY r141 446
participant stoichiometry: PARTICIPANT STOICHIOMETRY r141 445
left: FVIIIa
left: FIXa
interaction type: HETERODIMER_ASSOCIATION
right: Complex (FIXa/Ca2+/ FVIIIa/PL)

Amyloid-beta precursor protein
type: ProteinReference
xref: PTHR23103:SF7
xref: uniprot P05067 145
organism: Homo sapiens

Urokinase plasminogen activator surface receptor
type: ProteinReference
xref: PTHR10624:SF6
xref: uniprot Q05588 159
organism: Bos taurus

DISSOCIATION
type: InteractionVocabulary

Vitamin K-dependent protein S
type: ProteinReference
xref: uniprot Q08761 75
organism: Mus musculus

uniprot O08677 79
type: UnificationXref
id: O08677
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19143:SF338
xref: uniprot E1BV78 28
organism: Gallus gallus

GP Ibalpha s111 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP Ibalpha
stoichiometric coefficient: 1.0

uniprot F6YDX7 120
type: UnificationXref
id: F6YDX7
db: uniprot

Vitamin K-dependent protein C
type: ProteinReference
xref: PTHR24278:SF0
xref: uniprot P31394 118
organism: Rattus norvegicus

uniprot P22891 46
type: UnificationXref
id: P22891
db: uniprot

FVIIa
type: Protein
entity reference: FVIIa
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa39 332
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__Complex__GP_IIb_GP_IIIa_-_Fibrinogen-RIGHT__Complex__GP_IIIa_GP_IIb__Fibrinogen_-_r161
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r161 501
participant stoichiometry: PARTICIPANT STOICHIOMETRY r161 499
participant stoichiometry: PARTICIPANT STOICHIOMETRY r161 500
left: Complex (GP IIb/GP IIIa)
left: Fibrinogen
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GP IIIa/GP IIb/ Fibrinogen)

PZ s96 sa61 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PZ
stoichiometric coefficient: 1.0

PAI-2
type: ProteinReference
xref: P00409
standard name: plasminogen activator-inhibitors type 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: plasminogen activator-inhibitors type 2 Synonym: PAI-2,serine (or cysteine) protease inhibitor, clade B, member 2 Accession: P00409
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.PAI-2
member entity reference: Plasminogen activator inhibitor 2 type A
member entity reference: Uncharacterized protein
member entity reference: Plasminogen activator inhibitor 2
member entity reference: Serpin family B member 2
member entity reference: Plasminogen activator inhibitor 2, macrophage

Coagulation factor XI
type: ProteinReference
xref: PTHR24253:SF44
xref: uniprot Q91Y47 161
organism: Mus musculus

Plasma kallikrein
type: ProteinReference
xref: PTHR24253:SF64
xref: uniprot P26262 169
organism: Mus musculus

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s93 sa51 376
comment: SPECIES_TYPE=ION

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 11

Tissue Factor
type: Protein
entity reference: Tissue Factor
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa178 292
comment: SPECIES_TYPE=PROTEIN

uniprot Q8K0E8 43
type: UnificationXref
id: Q8K0E8
db: uniprot

Prekallikrein
type: ProteinReference
xref: P00439
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.Prekallikrein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Prekallikrein Synonym: Fletcher factor Accession: P00439
member entity reference: Plasma kallikrein
member entity reference: Uncharacterized protein

Coagulation factor IX
type: ProteinReference
xref: uniprot P16294 113
xref: PTHR24278:SF31
organism: Mus musculus

Platelet glycoprotein V
type: ProteinReference
xref: PTHR45617:SF38
xref: uniprot O08770 103
organism: Rattus norvegicus

uniprot Q95ND7 115
type: UnificationXref
id: Q95ND7
db: uniprot

ncbitaxon 9258 139
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot O08675 199
type: UnificationXref
id: O08675
db: uniprot

Kallikrein s22 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Kallikrein
stoichiometric coefficient: 1.0

Prothrombin
type: ProteinReference
xref: PTHR24254:SF10
xref: uniprot P19221 89
organism: Mus musculus

Alpha-2-antiplasmin
type: ProteinReference
xref: PTHR11461:SF20
xref: uniprot P28800 134
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r122 410
type: Stoichiometry
physical entity: Complex (Thrombomodulin/Thrombin/ Ca2+/PL)
stoichiometric coefficient: 1.0

GP Ibalpha
type: Protein
entity reference: GP Ibalpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa10 262
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

BOOLEAN_LOGIC_GATE_OR
type: Control
xref: BOOLEAN LOGIC GATE OR
controlled: STATE_TRANSITION_LEFT__Plasmin-RIGHT__Plasmin-_re69

Platelet glycoprotein V
type: ProteinReference
xref: uniprot P40197 104
xref: PTHR45617:SF38
organism: Homo sapiens

Coagulation factor XIII A chain
type: ProteinReference
xref: PTHR11590:SF42
xref: uniprot Q8BH61 101
organism: Mus musculus

uniprot H2Q7U0 44
type: UnificationXref
id: H2Q7U0
db: uniprot

uniprot Q28520 76
type: UnificationXref
id: Q28520
db: uniprot

PS
type: ProteinReference
xref: P00412
standard name: Protein S
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein S Synonym: PS Accession: P00412
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.PS
member entity reference: PROS1 isoform 1
member entity reference: Vitamin K-dependent protein S
member entity reference: Vitamin K-dependent protein S (Fragment)

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__uPA-RIGHT__uPA-_r90
control type: INHIBITION
controller: PAI-1

uniprot P26262 169
type: UnificationXref
id: P26262
db: uniprot

GP V s114 sa76 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GP V
stoichiometric coefficient: 1.0

Complex (PS/APC)
type: Complex
component stoichiometry: PS s7 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: APC s8 sa2 STOICHIOMETRY ID COMPLEX
component: APC
component: PS
feature: ACTIVE 17
feature: COMPLEX BINDING FEATURE s52 a74 297
feature: COMPLEX BINDING FEATURE s52 a74 299

TRUNCATION_LEFT__FIX-RIGHT__FIXa-_?-_r157
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r157 398
participant stoichiometry: PARTICIPANT STOICHIOMETRY r157 399
participant stoichiometry: PARTICIPANT STOICHIOMETRY r157 400
left: FIX
interaction type: TRUNCATION
right: FIXa
right: ?

uniprot P00747 51
type: UnificationXref
id: P00747
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BTD3 132
xref: PTHR11461:SF20
organism: Macaca mulatta

Zn2 PLUS s78 a116 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Zn2+
stoichiometric coefficient: 1.0

PL
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa36 286
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Complex (Kallikrein/HMWK)
type: Complex
component stoichiometry: Kallikrein s22 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: HMWK s23 sa16 STOICHIOMETRY ID COMPLEX
component: Kallikrein
component: HMWK
feature: COMPLEX BINDING FEATURE s121 a179 315
feature: COMPLEX BINDING FEATURE s121 a179 317

Thrombomodulin
type: Protein
entity reference: Thrombomodulin
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa25 270
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r122 409
type: Stoichiometry
physical entity: Thrombin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re69 455
type: Stoichiometry
physical entity: Plasmin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r122 408
type: Stoichiometry
physical entity: Complex (Thrombomodulin/Ca2+/ PL)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re69 456
type: Stoichiometry
physical entity: Plasmin
stoichiometric coefficient: 1.0

Ca2 PLUS s58 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Plasminogen
type: ProteinReference
xref: P00408
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.Plasminogen
comment: ENTITY_REFERENCE_NOTES=Long Name: Plasminogen Synonym: Synonym not specified Accession: P00408
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Plasminogen

PC
type: Protein
entity reference: PC
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa13 360
comment: SPECIES_TYPE=PROTEIN

P00433
type: UnificationXref
id: P00433
db: PANTHER Pathway Component

P00434
type: UnificationXref
id: P00434
db: PANTHER Pathway Component

P00435
type: UnificationXref
id: P00435
db: PANTHER Pathway Component

P00436
type: UnificationXref
id: P00436
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR19143:SF338
xref: uniprot F6UZ20 31
organism: Macaca mulatta

P00437
type: UnificationXref
id: P00437
db: PANTHER Pathway Component

P00438
type: UnificationXref
id: P00438
db: PANTHER Pathway Component

P00439
type: UnificationXref
id: P00439
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR11339:SF361
xref: uniprot A0A1D5R0L5 187
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Complex__Kallikrein_HMWK_-RIGHT__Bradykinin-_Kininogen-_Kallikrein-_r168
controller: Complex (Kallikrein/HMWK)

Ca2 PLUS s90 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PL
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa32 256
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P16294 113
type: UnificationXref
id: P16294
db: uniprot

PARTICIPANT STOICHIOMETRY r87 483
type: Stoichiometry
physical entity: tPA
stoichiometric coefficient: 1.0

PL s64 sa179 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PL
stoichiometric coefficient: 1.0

P00441
type: UnificationXref
id: P00441
db: PANTHER Pathway Component

P00440
type: UnificationXref
id: P00440
db: PANTHER Pathway Component

P00443
type: UnificationXref
id: P00443
db: PANTHER Pathway Component

P00442
type: UnificationXref
id: P00442
db: PANTHER Pathway Component

P00424
type: UnificationXref
id: P00424
db: PANTHER Pathway Component

P00425
type: UnificationXref
id: P00425
db: PANTHER Pathway Component

P00422
type: UnificationXref
id: P00422
db: PANTHER Pathway Component

P00423
type: UnificationXref
id: P00423
db: PANTHER Pathway Component

P00428
type: UnificationXref
id: P00428
db: PANTHER Pathway Component

P00429
type: UnificationXref
id: P00429
db: PANTHER Pathway Component

P00426
type: UnificationXref
id: P00426
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r87 482
type: Stoichiometry
physical entity: tPA
stoichiometric coefficient: 1.0

Ca2 PLUS s40 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

P00427
type: UnificationXref
id: P00427
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r141 447
type: Stoichiometry
physical entity: Complex (FIXa/Ca2+/ FVIIIa/PL)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r141 446
type: Stoichiometry
physical entity: FVIIIa
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Kininogen
type: Protein
entity reference: Kininogen
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r141 445
type: Stoichiometry
physical entity: FIXa
stoichiometric coefficient: 1.0

ZPI s95 sa60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ZPI
stoichiometric coefficient: 1.0

GP V
type: Protein
entity reference: GP V
feature: COMPLEX PARTICIPANT BINDING FEATURE s112 sa74 346
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

uniprot P02675 36
type: UnificationXref
id: P02675
db: uniprot

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 87

ncbitaxon 10090 9
type: UnificationXref
id: 10090
db: ncbitaxon

P00432
type: UnificationXref
id: P00432
db: PANTHER Pathway Component

P00431
type: UnificationXref
id: P00431
db: PANTHER Pathway Component

uniprot E1BV78 28
type: UnificationXref
id: E1BV78
db: uniprot

P00430
type: UnificationXref
id: P00430
db: PANTHER Pathway Component

uniprot P15120 123
type: UnificationXref
id: P15120
db: uniprot

uniprot P02679 38
type: UnificationXref
id: P02679
db: uniprot

uniprot H2Q7T9 140
type: UnificationXref
id: H2Q7T9
db: uniprot

P00455
type: UnificationXref
id: P00455
db: PANTHER Pathway Component

Integrin beta
type: ProteinReference
xref: PTHR10082:SF25
xref: uniprot Q92071 219
organism: Gallus gallus

P00456
type: UnificationXref
id: P00456
db: PANTHER Pathway Component

Ca2 PLUS s93 sa51 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

P00457
type: UnificationXref
id: P00457
db: PANTHER Pathway Component

P00458
type: UnificationXref
id: P00458
db: PANTHER Pathway Component

uniprot F6SG43 78
type: UnificationXref
id: F6SG43
db: uniprot

Coagulation factor VIII
type: ProteinReference
xref: uniprot P00451 23
xref: PTHR24543:SF310
organism: Homo sapiens

Antithrombin-III
type: ProteinReference
xref: PTHR11461:SF53
xref: uniprot P41361 175
organism: Bos taurus

Heparan
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s202 sa173 280
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Integrin beta-3
type: ProteinReference
xref: PTHR10082:SF25
xref: uniprot O54890 218
organism: Mus musculus

P00461
type: UnificationXref
id: P00461
db: PANTHER Pathway Component

P00460
type: UnificationXref
id: P00460
db: PANTHER Pathway Component

P00448
type: UnificationXref
id: P00448
db: PANTHER Pathway Component

P00449
type: UnificationXref
id: P00449
db: PANTHER Pathway Component

TRUNCATION_LEFT__FX-RIGHT__FXa-_?-_r159
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r159 393
participant stoichiometry: PARTICIPANT STOICHIOMETRY r159 391
participant stoichiometry: PARTICIPANT STOICHIOMETRY r159 392
left: FX
interaction type: TRUNCATION
right: FXa
right: ?

PTHR24253:SF44
type: RelationshipXref
id: PTHR24253:SF44
db: PANTHER Family
relationship type: By Homology

P00446
type: UnificationXref
id: P00446
db: PANTHER Pathway Component

P00447
type: UnificationXref
id: P00447
db: PANTHER Pathway Component

uniprot A0A2J8QMJ1 105
type: UnificationXref
id: A0A2J8QMJ1
db: uniprot

uniprot H2QQB5 34
type: UnificationXref
id: H2QQB5
db: uniprot

P00444
type: UnificationXref
id: P00444
db: PANTHER Pathway Component

P00445
type: UnificationXref
id: P00445
db: PANTHER Pathway Component

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__FXIa-RIGHT__FXIa-_re71
control type: ACTIVATION
controller: ATiii heparin complex

FXa s91 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FXa
stoichiometric coefficient: 1.0

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__tPA-RIGHT__tPA-_r87
control type: INHIBITION
controller: PAI-1

uniprot P05121 68
type: UnificationXref
id: P05121
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__uPA-RIGHT__uPA-_r90
controller: Plasmin

tPA
type: Protein
entity reference: tPA
comment: SPECIES_TYPE=PROTEIN

Protein Z-dependent protease inhibitor
type: ProteinReference
xref: PTHR11461:SF191
xref: uniprot Q8R121 127
organism: Mus musculus

Serpin family E member 1
type: ProteinReference
xref: PTHR11461:SF49
xref: uniprot F1PUI4 65
organism: Canis lupus familiaris

P00454
type: UnificationXref
id: P00454
db: PANTHER Pathway Component

P00453
type: UnificationXref
id: P00453
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR11461:SF61
xref: uniprot F6TWU5 54
organism: Macaca mulatta

P00452
type: UnificationXref
id: P00452
db: PANTHER Pathway Component

Platelet glycoprotein IX
type: ProteinReference
xref: PTHR22650:SF6
xref: uniprot O88186 202
organism: Mus musculus

P00451
type: UnificationXref
id: P00451
db: PANTHER Pathway Component

P00450
type: UnificationXref
id: P00450
db: PANTHER Pathway Component

Platelet glycoprotein Ib alpha chain
type: ProteinReference
xref: uniprot P07359 193
xref: PTHR24373:SF278
organism: Homo sapiens

a52_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

HCII
type: ProteinReference
xref: P00456
standard name: heparin cofactor II
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: heparin cofactor II Synonym: HCII Accession: P00456
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.HCII
member entity reference: Serpin peptidase inhibitor, clade D (heparin cofactor), member 1
member entity reference: Heparin cofactor 2
member entity reference: Uncharacterized protein

TRUNCATION_LEFT__PC-RIGHT__APC-_?-_r155
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r155 406
participant stoichiometry: PARTICIPANT STOICHIOMETRY r155 407
participant stoichiometry: PARTICIPANT STOICHIOMETRY r155 405
left: PC
interaction type: TRUNCATION
right: APC
right: ?

uniprot F7BTD3 132
type: UnificationXref
id: F7BTD3
db: uniprot

Zn2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 a116 226
comment: SPECIES_TYPE=ION

PZ s98 sa63 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PZ
stoichiometric coefficient: 1.0

uniprot F6SEN6 106
type: UnificationXref
id: F6SEN6
db: uniprot

SERPINA1 isoform 1
type: ProteinReference
xref: uniprot A0A2J8QMJ1 105
xref: PTHR11461:SF165
organism: Pan troglodytes

PROZ isoform 2
type: ProteinReference
xref: uniprot H2Q7U0 44
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__PC_EPCR_-RIGHT__EPCR-_APC-_r132
controller: Complex (Thrombomodulin/Thrombin/ Ca2+/PL)

FXa
type: Protein
entity reference: FXa
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa49 372
comment: SPECIES_TYPE=PROTEIN

Fibrinogen alpha chain
type: ProteinReference
xref: PTHR47221:SF1
xref: uniprot P06399 39
organism: Rattus norvegicus

uniprot A0A452DIF6 151
type: UnificationXref
id: A0A452DIF6
db: uniprot

uniprot P00750 153
type: UnificationXref
id: P00750
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

PTHR45617:SF38
type: RelationshipXref
id: PTHR45617:SF38
db: PANTHER Family
relationship type: By Homology

Ca2 PLUS s73 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r132 487
type: Stoichiometry
physical entity: EPCR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r132 486
type: Stoichiometry
physical entity: Complex (PC/EPCR)
stoichiometric coefficient: 1.0

FXII
type: ProteinReference
xref: P00442
standard name: Factor XII
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FXII
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Factor XII Synonym: Hageman Factor Accession: P00442
member entity reference: Coagulation factor XII
member entity reference: Uncharacterized protein

PARTICIPANT STOICHIOMETRY r132 488
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

alpha1-antitrypsin
type: Protein
entity reference: alpha1-antitrypsin
comment: SPECIES_TYPE=PROTEIN

FIX
type: ProteinReference
xref: P00444
standard name: Factor IX
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Factor IX Synonym: Christmas Factor,antihemophilic factor B,plasma thromboplastin component (PTC Accession: P00444
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FIX
member entity reference: Coagulation factor IX
member entity reference: Uncharacterized protein

PARTICIPANT STOICHIOMETRY r165 479
type: Stoichiometry
physical entity: Complex (FXa/FVa/ Ca2+/PL)
stoichiometric coefficient: 1.0

Plasminogen
type: Protein
entity reference: Plasminogen
comment: SPECIES_TYPE=PROTEIN

mPAR-3
type: Protein
entity reference: mPAR-3
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

PZ
type: Protein
entity reference: PZ
feature: COMPLEX PARTICIPANT BINDING FEATURE s98 sa63 234
comment: SPECIES_TYPE=PROTEIN

PTHR24253:SF64
type: RelationshipXref
id: PTHR24253:SF64
db: PANTHER Family
relationship type: By Homology

TFPI
type: Protein
entity reference: TFPI
comment: SPECIES_TYPE=PROTEIN

Coagulation factor X
type: ProteinReference
xref: uniprot Q63207 143
xref: PTHR24278:SF28
organism: Rattus norvegicus

uniprot A0A1D5Q7U7 166
type: UnificationXref
id: A0A1D5Q7U7
db: uniprot

FXa
type: Protein
entity reference: FXa
feature: COMPLEX PARTICIPANT BINDING FEATURE s99 sa64 236
comment: SPECIES_TYPE=PROTEIN

Fibrinogen alpha chain
type: ProteinReference
xref: PTHR47221:SF1
xref: uniprot P02671 35
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Fibrin_polymer_cross_linked-RIGHT__a52_degraded-_r41
controller: Plasmin

Fibrinogen gamma chain
type: ProteinReference
xref: PTHR19143:SF338
xref: uniprot P02679 38
organism: Homo sapiens

Fibrinogen beta chain
type: ProteinReference
xref: uniprot P02676 37
organism: Bos taurus

FIXa s105 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FIXa
stoichiometric coefficient: 1.0

Coagulation factor VIII
type: ProteinReference
xref: PTHR24543:SF310
xref: uniprot Q06194 24
organism: Mus musculus

Fibrin polymer cross-linked
type: Protein
entity reference: Fibrin polymer cross-linked
comment: SPECIES_TYPE=PROTEIN

Fibrinogen beta chain
type: ProteinReference
xref: PTHR19143:SF332
xref: uniprot P02675 36
organism: Homo sapiens

uniprot O08742 102
type: UnificationXref
id: O08742
db: uniprot

Complex (HMWK/FXI)
type: Complex
component stoichiometry: FXI s10 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: HMWK s9 sa5 STOICHIOMETRY ID COMPLEX
component: HMWK
component: FXI
feature: COMPLEX BINDING FEATURE s77 a115 301
feature: COMPLEX BINDING FEATURE s77 a115 303

FVIIIa
type: ProteinReference
xref: P00446
standard name: Factor VIIa
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.FVIIIa
comment: ENTITY_REFERENCE_NOTES=Long Name: FVIIIa Synonym: Synonym not specified Accession: P00446
member entity reference: Coagulation factor VIII
member entity reference: Uncharacterized protein

uniprot H2QU06 50
type: UnificationXref
id: H2QU06
db: uniprot

PARTICIPANT STOICHIOMETRY r156 401
type: Stoichiometry
physical entity: Complex (vWF/FVIII)
stoichiometric coefficient: 1.0

P00419
type: UnificationXref
id: P00419
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r156 404
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

P00416
type: UnificationXref
id: P00416
db: PANTHER Pathway Component

uniprot O54890 218
type: UnificationXref
id: O54890
db: uniprot

P00415
type: UnificationXref
id: P00415
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r156 402
type: Stoichiometry
physical entity: vWF
stoichiometric coefficient: 1.0

P00418
type: UnificationXref
id: P00418
db: PANTHER Pathway Component

PL
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa24 268
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r156 403
type: Stoichiometry
physical entity: FVIIIa
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r127 390
type: Stoichiometry
physical entity: Complex (Tissue Factor/FVIIa/ PL/Ca2+/ FXa)
stoichiometric coefficient: 1.0

P00417
type: UnificationXref
id: P00417
db: PANTHER Pathway Component

P00412
type: UnificationXref
id: P00412
db: PANTHER Pathway Component

P00411
type: UnificationXref
id: P00411
db: PANTHER Pathway Component

P00414
type: UnificationXref
id: P00414
db: PANTHER Pathway Component

P00413
type: UnificationXref
id: P00413
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r160 504
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

P00420
type: UnificationXref
id: P00420
db: PANTHER Pathway Component

P00421
type: UnificationXref
id: P00421
db: PANTHER Pathway Component

PTHR24261:SF13
type: RelationshipXref
id: PTHR24261:SF13
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r160 503
type: Stoichiometry
physical entity: FXIIIa
stoichiometric coefficient: 1.0

uniprot Q07968 100
type: UnificationXref
id: Q07968
db: uniprot

PARTICIPANT STOICHIOMETRY r160 502
type: Stoichiometry
physical entity: FXIII
stoichiometric coefficient: 1.0

Alpha-1-antiproteinase
type: ProteinReference
xref: uniprot P34955 109
xref: PTHR11461:SF165
organism: Bos taurus

uniprot P01009 107
type: UnificationXref
id: P01009
db: uniprot

PARTICIPANT STOICHIOMETRY r161 501
type: Stoichiometry
physical entity: Complex (GP IIIa/GP IIb/ Fibrinogen)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r161 500
type: Stoichiometry
physical entity: Fibrinogen
stoichiometric coefficient: 1.0

Complex (FIXa/Ca2+/ FVIIIa/PL)
type: Complex
component stoichiometry: FVIIIa s107 sa69 STOICHIOMETRY ID COMPLEX
component stoichiometry: FIXa s105 sa67 STOICHIOMETRY ID COMPLEX
component stoichiometry: PL s108 sa70 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s106 sa68 STOICHIOMETRY ID COMPLEX
component: PL
component: FVIIIa
component: Ca2+
component: FIXa
feature: ACTIVE 17
feature: COMPLEX BINDING FEATURE s184 a306 369
feature: COMPLEX BINDING FEATURE s184 a306 365
feature: COMPLEX BINDING FEATURE s184 a306 363
feature: COMPLEX BINDING FEATURE s184 a306 367

TRUNCATION_LEFT__FXIII-RIGHT__FXIIIa-_?-_r160
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r160 502
participant stoichiometry: PARTICIPANT STOICHIOMETRY r160 504
participant stoichiometry: PARTICIPANT STOICHIOMETRY r160 503
left: FXIII
interaction type: TRUNCATION
right: FXIIIa
right: ?

alpha1-antitrypsin
type: ProteinReference
xref: P00421
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: alpha1-antitrypsin Synonym: AAT,APS,alpha-1-antiproteinase,alpha-1-protease inhibitor,alpha1-AT Accession: P00421
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC._alpha_1-antitrypsin
member entity reference: Alpha-1-antiproteinase
member entity reference: Alpha-1-antitrypsin
member entity reference: SERPINA1 isoform 1

uniprot F6XAB8 96
type: UnificationXref
id: F6XAB8
db: uniprot

PARTICIPANT STOICHIOMETRY r127 388
type: Stoichiometry
physical entity: Complex (FVIIa/Tissue Factor/ PL/Ca2+)
stoichiometric coefficient: 1.0

Vitamin K-dependent protein Z
type: ProteinReference
xref: uniprot P22891 46
organism: Homo sapiens

Coagulation factor X
type: ProteinReference
xref: uniprot H2Q7T9 140
xref: PTHR24278:SF28
organism: Pan troglodytes

GP IX
type: Protein
entity reference: GP IX
feature: COMPLEX PARTICIPANT BINDING FEATURE s109 sa71 340
cellular location: activated platelet c1
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r127 389
type: Stoichiometry
physical entity: FXa
stoichiometric coefficient: 1.0

P00409
type: UnificationXref
id: P00409
db: PANTHER Pathway Component

P00408
type: UnificationXref
id: P00408
db: PANTHER Pathway Component

P00407
type: UnificationXref
id: P00407
db: PANTHER Pathway Component

uniprot P49182 207
type: UnificationXref
id: P49182
db: uniprot

P00406
type: UnificationXref
id: P00406
db: PANTHER Pathway Component

P00405
type: UnificationXref
id: P00405
db: PANTHER Pathway Component

P00404
type: UnificationXref
id: P00404
db: PANTHER Pathway Component

P00403
type: UnificationXref
id: P00403
db: PANTHER Pathway Component

uniprot Q06194 24
type: UnificationXref
id: Q06194
db: uniprot

Thrombin
type: ProteinReference
xref: P00414
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.Thrombin
comment: ENTITY_REFERENCE_NOTES=Long Name: Thrombin Synonym: Factor IIa Accession: P00414
member entity reference: Prothrombin
member entity reference: Uncharacterized protein

ATIII
type: Protein
entity reference: ATIII
feature: COMPLEX PARTICIPANT BINDING FEATURE s203 sa172 278
comment: SPECIES_TYPE=PROTEIN

P00410
type: UnificationXref
id: P00410
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r167 467
type: Stoichiometry
physical entity: Prothrombin
stoichiometric coefficient: 1.0

FVIIa s81 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FVIIa
stoichiometric coefficient: 1.0

TFPI
type: ProteinReference
xref: P00417
standard name: Tissue Factor Pathway Inhibitor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Tissue Factor Pathway Inhibitor Synonym: TFPI,anticonvertin,extrinsic pathway inhibitor (EPI),lipoprotein-associated coagulation inhibitor (LACI) Accession: P00417
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.GENERIC.TFPI
member entity reference: Tissue factor pathway inhibitor

Bradykinin
type: ProteinReference
xref: P00438
comment: ENTITY_REFERENCE_NOTES=Long Name: Bradykinin Synonym: Synonym not specified Accession: P00438
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=Blood coagulation.PROTEIN.TRUNCATED.Bradykinin
member entity reference: KNG1 isoform 2
member entity reference: Kininogen-1
member entity reference: Uncharacterized protein
member entity reference: Kininogen-2

PARTICIPANT STOICHIOMETRY r167 468
type: Stoichiometry
physical entity: Thrombin
stoichiometric coefficient: 1.0

Tissue factor
type: ProteinReference
xref: uniprot P13726 195
xref: PTHR20859:SF22
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r167 469
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

uniprot P00744 45
type: UnificationXref
id: P00744
db: uniprot