PARTICIPANT STOICHIOMETRY re374 1220
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

VMAT2
type: Protein
entity reference: VMAT2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED_LEFT__CCK_33-RIGHT__CCK-_re491
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re491 1028
participant stoichiometry: PARTICIPANT STOICHIOMETRY re491 1027
left: CCK-33
interaction type: KNOWN_TRANSITION_OMITTED
right: CCK

PARTICIPANT STOICHIOMETRY re374 1221
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CCK_G-RIGHT__CCK-_re494
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re494 1022
participant stoichiometry: PARTICIPANT STOICHIOMETRY re494 1021
left: CCK-G
interaction type: STATE_TRANSITION
right: CCK

G07277
type: UnificationXref
id: G07277
db: PANTHER Pathway Component

G07278
type: UnificationXref
id: G07278
db: PANTHER Pathway Component

uniprot P15056 157
type: UnificationXref
id: P15056
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Conventional_PKC-RIGHT__Conventional_PKC-_re19
control type: ACTIVATION
controller: DAG

G07279
type: UnificationXref
id: G07279
db: PANTHER Pathway Component

S264 CCK1R s866 sa458 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S264
feature location: S264 CCK1R s866 sa458 rs2 S264
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.459733321203526
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S264

STATE_TRANSITION_LEFT__CCK-RIGHT__CCK_58-_re497
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re497 1017
participant stoichiometry: PARTICIPANT STOICHIOMETRY re497 1018
left: CCK
interaction type: STATE_TRANSITION
right: CCK-58

G07285
type: UnificationXref
id: G07285
db: PANTHER Pathway Component

G07284
type: UnificationXref
id: G07284
db: PANTHER Pathway Component

G07287
type: UnificationXref
id: G07287
db: PANTHER Pathway Component

S1261 mTOR s924 sa308 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S1261
feature location: S1261 mTOR s924 sa308 rs1 S1261
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S1261
comment: MODIFICATION_RESIDUE_ANGLE=5.501842555985567

G07286
type: UnificationXref
id: G07286
db: PANTHER Pathway Component

G07281
type: UnificationXref
id: G07281
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re484 1057
type: Stoichiometry
physical entity: PPARgamma
stoichiometric coefficient: 1.0

G07280
type: UnificationXref
id: G07280
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re484 1058
type: Stoichiometry
physical entity: s1447
stoichiometric coefficient: 1.0

G07283
type: UnificationXref
id: G07283
db: PANTHER Pathway Component

G07282
type: UnificationXref
id: G07282
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re633 743
type: Stoichiometry
physical entity: Cytochrome C
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re498 1013
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re498 1014
type: Stoichiometry
physical entity: CCK-83
stoichiometric coefficient: 1.0

NAADP
type: SmallMolecule
cellular location: Lysosome
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P29353 31
type: UnificationXref
id: P29353
db: uniprot

S241 PDPK1 s76 sa164 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S241
feature location: S241 PDPK1 s76 sa164 rs1 S241
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=0.7668909901804244
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S241

HETERODIMER_ASSOCIATION_LEFT__COX2-_HuR-RIGHT__HuR_COX2-_re443
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re443 1170
participant stoichiometry: PARTICIPANT STOICHIOMETRY re443 1171
participant stoichiometry: PARTICIPANT STOICHIOMETRY re443 1169
left: COX2
left: HuR
interaction type: HETERODIMER_ASSOCIATION
right: HuR-COX2

G07268
type: UnificationXref
id: G07268
db: PANTHER Pathway Component

p110
type: ProteinReference
xref: P07020
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p110
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

G07269
type: UnificationXref
id: G07269
db: PANTHER Pathway Component

G07266
type: UnificationXref
id: G07266
db: PANTHER Pathway Component

Urokinase-type plasminogen activator
type: DnaReference
xref: PTHR24264:SF38
organism: Homo sapiens

G07267
type: UnificationXref
id: G07267
db: PANTHER Pathway Component

G07276
type: UnificationXref
id: G07276
db: PANTHER Pathway Component

G07275
type: UnificationXref
id: G07275
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re123 1062
type: Stoichiometry
physical entity: p70S6K1
stoichiometric coefficient: 1.0

G07274
type: UnificationXref
id: G07274
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re123 1061
type: Stoichiometry
physical entity: p70S6K1
stoichiometric coefficient: 1.0

G07273
type: UnificationXref
id: G07273
db: PANTHER Pathway Component

p46 SHC1
type: Protein
entity reference: p46 SHC1
feature: Y239 240 p46 SHC1 s722 sa100 rs2
feature: ACTIVE 13
feature: Y317 p46 SHC1 s722 sa100 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

G07272
type: UnificationXref
id: G07272
db: PANTHER Pathway Component

GSK3beta
type: Protein
entity reference: GSK3 beta PROTEIN
feature: S9 GSK3beta s978 sa198 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

G07271
type: UnificationXref
id: G07271
db: PANTHER Pathway Component

G07270
type: UnificationXref
id: G07270
db: PANTHER Pathway Component

T443 CCK2R s1688 sa565 rs11
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T443
feature location: T443 CCK2R s1688 sa565 rs11 T443
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T443
comment: MODIFICATION_RESIDUE_ANGLE=0.25278736068041796

S847 NOS1 s1268 sa631 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S847
feature location: S847 NOS1 s1268 sa631 rs1 S847
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.399827721492203
comment: MODIFICATION_RESIDUE_NAME=S847

HETERODIMER_ASSOCIATION_LEFT__Complex__GRB2_SOS1_-_IRS1-RIGHT__IRS_1_GRB2_SOS1-_re528
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re528 1036
participant stoichiometry: PARTICIPANT STOICHIOMETRY re528 1035
participant stoichiometry: PARTICIPANT STOICHIOMETRY re528 1037
left: IRS1
left: Complex (GRB2/SOS1)
interaction type: HETERODIMER_ASSOCIATION
right: IRS-1-GRB2-SOS1

CAS
type: Protein
entity reference: CAS
feature: Y460 CAS s764 sa117 rs4
feature: Y764 CAS s764 sa117 rs2
feature: Y762 CAS s764 sa117 rs1
feature: Y332 CAS s764 sa117 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CCK1R__active_-RIGHT__CCK1R__inactive_-_re287
controller: PKC

LYN
type: ProteinReference
xref: P07141
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.LYN
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Tyrosine-protein kinase Lyn

TRANSCRIPTION_LEFT__MOB1-RIGHT__MOB1-_re501
type: TemplateReaction
product: MOB1
xref: TRANSCRIPTION
participant: MOB1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

AKAP
type: Protein
entity reference: AKAP
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

ATF2
type: Protein
entity reference: ATF2 PROTEIN
feature: T71 ATF2 s1283 sa757 rs2
feature: ACTIVE 13
feature: T69 ATF2 s1283 sa757 rs1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re3
controller: IP3

TRANSLATION_LEFT__IEX1-RIGHT__IEX1-_re610
type: TemplateReaction
product: IEX1
xref: TRANSLATION
participant: IEX1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

DAG
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

EIF4E s733 sa314 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EIF4E s733 sa314
stoichiometric coefficient: 1.0

uniprot P11926 71
type: UnificationXref
id: P11926
db: uniprot

S442 CCK2R s1660 sa22 rs10
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S442
feature location: S442 CCK2R s1660 sa22 rs10 S442
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=6.097097937454755
comment: MODIFICATION_RESIDUE_NAME=S442

S1261 mTOR s958 sa316 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S1261
feature location: S1261 mTOR s958 sa316 rs1 S1261
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S1261
comment: MODIFICATION_RESIDUE_ANGLE=5.501842555985567

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Gastric mucosa differentiation
controller: HDC

COX2
type: DnaRegion
entity reference: COX2
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

RSK1/2
type: Protein
entity reference: RSK1/2
feature: S221 RSK1 2 s546 sa329 rs5
feature: T359 RSK1 2 s546 sa329 rs2
feature: S363 RSK1 2 s546 sa329 rs1
feature: ACTIVE 13
feature: T573 RSK1 2 s546 sa329 rs3
feature: S380 RSK1 2 s546 sa329 rs4
feature: S749 RSK1 2 s546 sa329 rs6
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re633 742
type: Stoichiometry
physical entity: Cytochrome C
stoichiometric coefficient: 1.0

SOS1
type: Protein
entity reference: SOS1
feature: S SOS1 s910 sa278 rs2
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s910 sa278 410
feature: T SOS1 s910 sa278 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Proline-rich AKT1 substrate 1
type: ProteinReference
xref: PTHR21844:SF2
xref: uniprot Q96B36 115
organism: Homo sapiens

S82 CCK2R s1660 sa22 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S82
feature location: S82 CCK2R s1660 sa22 rs2 S82
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.827433388230814
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S82

G07288
type: UnificationXref
id: G07288
db: PANTHER Pathway Component

G07289
type: UnificationXref
id: G07289
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 493
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 492
left: IP3R
interaction type: STATE_TRANSITION
right: IP3R

uniprot P27986 46
type: UnificationXref
id: P27986
db: uniprot

G07294
type: UnificationXref
id: G07294
db: PANTHER Pathway Component

HETERODIMER_ASSOCIATION_LEFT__Complex__GRB2_SOS1_-_p52_SHC1-RIGHT__p52SHC1_GRB2_SOS1-_re67
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 678
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 679
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 680
left: p52 SHC1 s721 sa101
left: Complex (GRB2/SOS1)
interaction type: HETERODIMER_ASSOCIATION
right: p52SHC1-GRB2-SOS1

G07293
type: UnificationXref
id: G07293
db: PANTHER Pathway Component

G07292
type: UnificationXref
id: G07292
db: PANTHER Pathway Component

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Migration
controller: PI3K Class I

G07291
type: UnificationXref
id: G07291
db: PANTHER Pathway Component

Y402 FAK2 s1892 sa975 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y402
feature location: Y402 FAK2 s1892 sa975 rs1 Y402
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.37
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y402

G07296
type: UnificationXref
id: G07296
db: PANTHER Pathway Component

G07295
type: UnificationXref
id: G07295
db: PANTHER Pathway Component

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRKD1-RIGHT__PRKD1-_re27
controller: PKCtheta

S158 HuR s1073 sa731 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S158
feature location: S158 HuR s1073 sa731 rs1 S158
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.67
comment: MODIFICATION_RESIDUE_NAME=S158
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

G07290
type: UnificationXref
id: G07290
db: PANTHER Pathway Component

PTHR11502:SF16
type: RelationshipXref
id: PTHR11502:SF16
db: PANTHER Family
relationship type: By Homology

Apoptosis
type: Pathway

PTHR10912:SF5
type: RelationshipXref
id: PTHR10912:SF5
db: PANTHER Family
relationship type: By Homology

p60 SRC
type: Protein
entity reference: p60 SRC
feature: Y527 p60 SRC s880 sa97 rs2
feature: ACTIVE 13
feature: Y416 p60 SRC s880 sa97 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Transcription factor Sp3
type: ProteinReference
xref: uniprot Q02447 116
xref: PTHR23235:SF3
organism: Homo sapiens

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Inflammatory response
controller: PAI2

BAD
type: Protein
entity reference: BAD
feature: S112 BAD s1615 sa893 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1615 sa893 218
feature: S136 BAD s1615 sa893 rs2
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

uniprot Q92934 95
type: UnificationXref
id: Q92934
db: uniprot

HBEGF
type: DnaRegion
entity reference: HBEGF
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

T69 ATF2 s1835 sa330 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T69
feature location: T69 ATF2 s1835 sa330 rs1 T69
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T69

uniprot P01350 36
type: UnificationXref
id: P01350
db: uniprot

T219 MAPK7 s1971 sa989 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T219
feature location: T219 MAPK7 s1971 sa989 rs1 T219
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.387506044879286
comment: MODIFICATION_RESIDUE_NAME=T219

TRANSPORT_LEFT__JUN-RIGHT__JUN-_re538
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re538 995
participant stoichiometry: PARTICIPANT STOICHIOMETRY re538 996
left: JUN
interaction type: TRANSPORT
right: JUN

PTHR11250:SF3
type: RelationshipXref
id: PTHR11250:SF3
db: PANTHER Family
relationship type: By Homology

NFKB1 (p50)
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1880 sa971 354
feature: NFKB1 p50 s1880 sa971 rs1
comment: SPECIES_TYPE=PROTEIN

T41 beta catenin s1862 sa635 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T41
feature location: T41 beta catenin s1862 sa635 rs4 T41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T41
comment: MODIFICATION_RESIDUE_ANGLE=2.3739822534748654

Y416 SRC @Galphaq s1599 sa887 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 SRC @Galphaq s1599 sa887 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789

S NFAT1 s2017 sa1014 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S NFAT1 s2017 sa1014 rs1 S
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8365926382770912

TRANSPORT_LEFT__CHGA-RIGHT__CHGA-_re251
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re251 687
participant stoichiometry: PARTICIPANT STOICHIOMETRY re251 686
left: CHGA
interaction type: TRANSPORT
right: CHGA

PARTICIPANT STOICHIOMETRY re480 1071
type: Stoichiometry
physical entity: Galpha q complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re480 1070
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

TACR1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.TACR1
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re173 872
type: Stoichiometry
physical entity: c-RAF / RAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re173 873
type: Stoichiometry
physical entity: c-RAF / RAF1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__BAD_BCL2_heterodimer-RIGHT__BAD_BCL2_heterodimer-_re564
controller: PAK1

STATE_TRANSITION_LEFT__TPC1_2-RIGHT__TPC1_2-_re360
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re360 518
participant stoichiometry: PARTICIPANT STOICHIOMETRY re360 519
left: TPC1/2
interaction type: STATE_TRANSITION
right: TPC1/2

FAK2 s1591 sa878 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK2
stoichiometric coefficient: 1.0

S497 9 RAF1 s156 sa686 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S497 9
feature location: S497 9 RAF1 s156 sa686 rs8 S497 9
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=6.261510357865046
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S497/9

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s687 sa251 294
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

IKBalpha
type: Protein
entity reference: IKBalpha
feature: S36 IKBalpha s852 sa62 rs2
feature: S32 IKBalpha s852 sa62 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Histone deacetylase 7
type: ProteinReference
xref: PTHR45634:SF9
xref: uniprot Q8WUI4 130
organism: Homo sapiens

Rho guanine nucleotide exchange factor 28
type: ProteinReference
xref: PTHR13944:SF22
xref: uniprot Q8N1W1 39
organism: Homo sapiens

KNOWN_TRANSITION_OMITTED_LEFT__MEF2C-RIGHT__MEF2-_re202
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re202 903
participant stoichiometry: PARTICIPANT STOICHIOMETRY re202 904
left: MEF2C
interaction type: KNOWN_TRANSITION_OMITTED
right: MEF2

CHGA
type: DnaRegionReference
member entity reference: Chromogranin-A
xref: G07271
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.CHGA
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re480 1067
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re480 1068
type: Stoichiometry
physical entity: G Protein complex
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__AKAP-RIGHT__PKA_Holoenzyme_II-_re549
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re549 954
participant stoichiometry: PARTICIPANT STOICHIOMETRY re549 953
left: AKAP
interaction type: KNOWN_TRANSITION_OMITTED
right: PKA Holoenzyme II

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1183 sa491 302
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re480 1069
type: Stoichiometry
physical entity: Gbeta/gamma
stoichiometric coefficient: 1.0

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__G17___Gly-RIGHT__G17-_re46
controller: PAM

CETP
type: ProteinReference
xref: P07189
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CETP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cholesteryl ester transfer protein

HBEGF
type: RnaRegion
entity reference: HBEGF
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

CALCA
type: DnaRegionReference
member entity reference: Calcitonin
xref: G07282
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.CALCA
comment: ENTITY_REFERENCE_NOTES=

S494 RAF1 s1336 sa692 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S494
feature location: S494 RAF1 s1336 sa692 rs5 S494
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.018263774283071
comment: MODIFICATION_RESIDUE_NAME=S494

PARTICIPANT STOICHIOMETRY re188 824
type: Stoichiometry
physical entity: CREB1
stoichiometric coefficient: 1.0

Gastrin_CCK2R_240212
type: Pathway
pathway component: KNOWN_TRANSITION_OMITTED
pathway component: STATE_TRANSITION_LEFT__Adenylate_cyclase-RIGHT__Adenylate_cyclase-_re294
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__CCK_58-RIGHT__CCK-_re490
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__BCL2L1-RIGHT__BCL2L1-_re636
pathway component: STATE_TRANSITION_LEFT__HDAC7-RIGHT__HDAC7-_re447
pathway component: STATE_TRANSITION_LEFT__SHC-RIGHT__SHC3-_re525
pathway component: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re3
pathway component: TRANSPORT_LEFT__CHGA-RIGHT__CHGA-_re251
pathway component: TRANSPORT_LEFT__TACR1-RIGHT__TACR1-_re512
pathway component: HETERODIMER_ASSOCIATION_LEFT__BCL2L1-_BAX-RIGHT__BAX_BCL2L1_heterodimer-_re559
pathway component: STATE_TRANSITION_LEFT__CD38-RIGHT__CD38-_re356
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__CCK_22-RIGHT__CCK-_re492
pathway component: DISSOCIATION_LEFT__Galpha13beta_gamma-_GTP-RIGHT__Galpha13-_GDP-_Gbeta_gamma-_re337
pathway component: STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_re453
pathway component: STATE_TRANSITION_LEFT__SP1-RIGHT__SP1-_re195
pathway component: STATE_TRANSITION_LEFT__SHC-RIGHT__SHC1-_re524
pathway component: STATE_TRANSITION_LEFT__CCK_GRR-RIGHT__CCK_G-_re305
pathway component: STATE_TRANSITION_LEFT__PI4,5_P2-RIGHT__PI3,4,5_P3-_re103
pathway component: TRANSPORT_LEFT__MOB1-RIGHT__MOB1-_re502
pathway component: UNKNOWN_TRANSITION_LEFT__SHP_2-RIGHT__AKT1_PIP3-_re584
pathway component: TRANSPORT_LEFT__PAI2-RIGHT__PAI2-_re229
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Atypical_PKC-RIGHT__PKC-_re24
pathway component: STATE TRANSITION LEFT JAK2-RIGHT JAK2- re98
pathway component: STATE_TRANSITION_LEFT__PDPK1-RIGHT__PDPK1-_re147
pathway component: DISSOCIATION_LEFT__PKA_Holoenzyme_II-_cAMP-RIGHT__PKA_Calpha_beta_gamma-_PKA_R2-_re548
pathway component: STATE_TRANSITION_LEFT__MAP2K2-RIGHT__MAP2K2-_re141
pathway component: HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__PI3K_Class_I-_re101
pathway component: STATE_TRANSITION_LEFT__c_RAF___RAF1-RIGHT__c_RAF___RAF1-_re173
pathway component: TRANSPORT_LEFT__CLU-RIGHT__CLU-_re602
pathway component: TRANSPORT_LEFT__FOS-RIGHT__FOS-_re539
pathway component: TRANSPORT_LEFT__IL8-RIGHT__IL8-_re439
pathway component: STATE_TRANSITION_LEFT__PLCbeta-RIGHT__PLCbeta-_re377
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__SRC_@Galphaq-RIGHT__Complex__HBEGF_EGFR_-_re62
pathway component: STATE_TRANSITION_LEFT__cGK_1-RIGHT__cGK_1-_re359
pathway component: STATE_TRANSITION_LEFT__PRKD2-RIGHT__PRKD2-_re446
pathway component: TRANSPORT_LEFT__ACAT1-RIGHT__ACAT1-_re467
pathway component: TRANSPORT_LEFT__Complex__GRB2_SOS1_-RIGHT__Complex__GRB2_SOS1_-_re65
pathway component: DISSOCIATION_LEFT__BAD_BCL2_heterodimer-RIGHT__BAD-_BCL2-_re577
pathway component: STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_re70
pathway component: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re556
pathway component: STATE_TRANSITION_LEFT__LYN-RIGHT__LYN-_re637
pathway component: STATE_TRANSITION_LEFT__MAPK7-RIGHT__MAPK7-_re170
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__ROCK1-RIGHT__BCL2L1-_re591
pathway component: STATE_TRANSITION_LEFT__RHOA_GTP-RIGHT__Pi-_RHOA_GDP-_re75
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GRB2_SOS1_-_SHC1_@EGFR-RIGHT__SHC1_GRB2_SOS1-_re66
pathway component: STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_re574
pathway component: STATE_TRANSITION_LEFT__ELK1-RIGHT__ELK1-_re189
pathway component: STATE_TRANSITION_LEFT__RSK1_2-RIGHT__RSK1_2-_re144
pathway component: HETERODIMER_ASSOCIATION_LEFT__Beta_arrestin_1_2-_CCK2R-RIGHT__active_CCK2R_beta_arrestin_complex-_re331
pathway component: STATE_TRANSITION_LEFT__Preprogastrin_@ER-RIGHT__Progastrin_@ER___Golgi-_re42
pathway component: TRANSCRIPTION_LEFT__HDC-RIGHT__HDC-_re437
pathway component: DISSOCIATION_LEFT__4E_BP1_EIF4E_complex-RIGHT__4E_BP1-_EIF4E-_re118
pathway component: STATE_TRANSITION_LEFT__NFAT1-RIGHT__NFAT1-_re668
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__p60_SRC-RIGHT__SRC_@Galphaq-_re575
pathway component: TRANSCRIPTION_LEFT__CLU-RIGHT__CLU-_re569
pathway component: TRANSPORT_LEFT__PAI1-RIGHT__PAI1-_re604
pathway component: STATE_TRANSITION_LEFT__PKCalpha-RIGHT__PKCalpha-_re7
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__CCK_8-RIGHT__CCK-_re493
pathway component: TRANSCRIPTION_LEFT__VMAT2-RIGHT__VMAT2-_re233
pathway component: TRANSLATION_LEFT__IEX1-RIGHT__IEX1-_re610
pathway component: HETERODIMER_ASSOCIATION_LEFT__BCL2-_BAD-RIGHT__BAD_BCL2_heterodimer-_re562
pathway component: HETERODIMER_ASSOCIATION_LEFT__Gbeta_gamma-_Galpha_q_complex-RIGHT__Pi-_G_Protein_complex-_re612
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Atypical_PKC-RIGHT__PKCzeta-_re14
pathway component: TRANSCRIPTION_LEFT__PAI1-RIGHT__PAI1-_re603
pathway component: STATE_TRANSITION_LEFT__PKCzeta-RIGHT__PKCzeta-_re11
pathway component: STATE_TRANSITION_LEFT__Progastrin_@Golgi-RIGHT__G34_Gly-_re479
pathway component: STATE_TRANSITION_LEFT__RSK1_2-RIGHT__RSK1_2-_re145
pathway component: STATE_TRANSITION_LEFT__MMP3-RIGHT__MMP3-_re51
pathway component: TRANSPORT_LEFT__MMP7-RIGHT__MMP7-_re419
pathway component: STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re408
pathway component: STATE_TRANSITION_LEFT__G34-RIGHT__G17-_re45
pathway component: TRANSCRIPTION_LEFT__IEX1-RIGHT__IEX1-_re608
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GRB2_SOS1_-_p46_SHC1-RIGHT__p46SHC1_GRB2_SOS1-_re68
pathway component: TRANSPORT LEFT TAC1-RIGHT TAC1- re509
pathway component: STATE_TRANSITION_LEFT__SRC_@Galphaq-RIGHT__SRC_@Galphaq-_re52
pathway component: STATE_TRANSITION_LEFT__GSK3beta-RIGHT__GSK3beta-_re369

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CREB1-RIGHT__CREB1-_re188
controller: NFKB1/RELA heterodimer

Y94 CCK s1779 sa948 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 CCK s1779 sa948 rs3 Y94
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.474173865666921
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y94

Synaptic vesicular amine transporter
type: DnaReference
xref: PTHR23506:SF30
organism: Homo sapiens

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

Protachykinin-1
type: DnaReference
xref: PTHR11250:SF3
organism: Homo sapiens

G07261
type: UnificationXref
id: G07261
db: PANTHER Pathway Component

TACR1
type: DnaRegionReference
member entity reference: Substance-P receptor
xref: G07279
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.TACR1
comment: ENTITY_REFERENCE_NOTES=

G07262
type: UnificationXref
id: G07262
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FOS-RIGHT__FOS-_re164
controller: MAPK1/3

G07263
type: UnificationXref
id: G07263
db: PANTHER Pathway Component

G07264
type: UnificationXref
id: G07264
db: PANTHER Pathway Component

G07265
type: UnificationXref
id: G07265
db: PANTHER Pathway Component

T SOS1 s910 sa278 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T SOS1 s910 sa278 rs1 T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_ANGLE=0.8611146530060259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

CaMKIV
type: ProteinReference
xref: P07198
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CaMKIV
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Calcium/calmodulin-dependent protein kinase type IV

KNOWN_TRANSITION_OMITTED_LEFT__CCK_58-RIGHT__CCK-_re490
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re490 1030
participant stoichiometry: PARTICIPANT STOICHIOMETRY re490 1029
left: CCK-58
interaction type: KNOWN_TRANSITION_OMITTED
right: CCK

CK1delta/epsilon
type: Protein
entity reference: CK1delta/epsilon
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__MYC-RIGHT__MYC-_re422
controller: beta-catenin/TCF-4

Synaptic vesicular amine transporter
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot Q05940 102
organism: Homo sapiens

T SOS1 s943 sa272 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T SOS1 s943 sa272 rs1 T
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_ANGLE=0.8611146530060259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

STATE_TRANSITION_LEFT__ICER-RIGHT__ICER-_re278
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re278 599
participant stoichiometry: PARTICIPANT STOICHIOMETRY re278 600
left: ICER
interaction type: STATE_TRANSITION
right: ICER

Peroxisome proliferator-activated receptor gamma
type: ProteinReference
xref: uniprot P37231 171
xref: PTHR24082:SF488
organism: Homo sapiens

UNKNOWN_TRANSITION_LEFT__CDC42_GTP-RIGHT__AKT1_PIP3-_re586
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re586 799
participant stoichiometry: PARTICIPANT STOICHIOMETRY re586 800
left: CDC42-GTP
interaction type: UNKNOWN_TRANSITION
right: AKT1-PIP3

PARTICIPANT STOICHIOMETRY re188 825
type: Stoichiometry
physical entity: CREB1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re77 647
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re77 646
type: Stoichiometry
physical entity: RAC1-GTP
stoichiometric coefficient: 1.0

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__CHGA-RIGHT__CHGA-_re232
controller: EGR1

Y868 JAK2 s1634 sa152 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y868
feature location: Y868 JAK2 s1634 sa152 rs1 Y868
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.715273327379819
comment: MODIFICATION_RESIDUE_NAME=Y868

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__TACR1-RIGHT__TACR1-_re511
controller: NFKB1/RELA heterodimer

PARTICIPANT STOICHIOMETRY re77 648
type: Stoichiometry
physical entity: RAC1-GDP
stoichiometric coefficient: 1.0

T423 PAK1 s786 sa136 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T423
feature location: T423 PAK1 s786 sa136 rs1 T423
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.719181924797195
comment: MODIFICATION_RESIDUE_NAME=T423

COX2
type: RnaRegion
entity reference: COX2
cellular location: CELL
comment: SPECIES_TYPE=RNA

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__A_Raf-RIGHT__A_Raf-_re378
controller: PKCtheta

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s2005 sa1003 418
cellular location: CELL
comment: SPECIES_TYPE=ION

PI3,4,5-P3
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

EIF4E
type: ProteinReference
xref: P07094
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.EIF4E
member entity reference: Eukaryotic translation initiation factor 4E

c-RAF / RAF1
type: ProteinReference
xref: P07213
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.c-RAF / RAF1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: RAF proto-oncogene serine/threonine-protein kinase

KNOWN_TRANSITION_OMITTED_LEFT__BCL2L1-RIGHT__BCL2L1-_re636
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re636 735
participant stoichiometry: PARTICIPANT STOICHIOMETRY re636 736
left: BCL2L1
interaction type: KNOWN_TRANSITION_OMITTED
right: BCL2L1

FAK2
type: Protein
entity reference: FAK2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1598 sa886 438
feature: Y579 FAK2 s1598 sa886 rs2
feature: ACTIVE 13
feature: Y580 FAK2 s1598 sa886 rs3
feature: Y402 FAK2 s1598 sa886 rs1
feature: Y881 FAK2 s1598 sa886 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re309 614
type: Stoichiometry
physical entity: FAK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re309 615
type: Stoichiometry
physical entity: FAK2
stoichiometric coefficient: 1.0

CCK1R
type: Protein
feature: S430 CCK1R s1485 sa456 rs4
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s1485 sa456 198
feature: S260 CCK1R s1485 sa456 rs1
feature: S307 CCK1R s1485 sa456 rs3
feature: S264 CCK1R s1485 sa456 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

MMP9
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.MMP9
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re201 905
type: Stoichiometry
physical entity: MEF2D
stoichiometric coefficient: 1.0

p52 SHC1
type: ProteinReference
xref: P07151
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p52 SHC1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: SHC-transforming protein 1

PARTICIPANT STOICHIOMETRY re201 906
type: Stoichiometry
physical entity: MEF2
stoichiometric coefficient: 1.0

MAPK1/3
type: Protein
entity reference: MAPK1/3
feature: Y204 MAPK1 3 s827 sa217 rs4
feature: ACTIVE 13
feature: T202 MAPK1 3 s827 sa217 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

4E-BP1
type: ProteinReference
xref: P07230
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.4E-BP1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Eukaryotic translation initiation factor 4E-binding protein 1

PARTICIPANT STOICHIOMETRY re585 802
type: Stoichiometry
physical entity: AKT1-PIP3
stoichiometric coefficient: 1.0

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__FOS-RIGHT__FOS-_re206
controller: SAP1

p66 SHC1
type: Protein
entity reference: p66 SHC1
feature: S36 p66 SHC1 s728 sa99 rs3
feature: ACTIVE 13
feature: Y239 240 p66 SHC1 s728 sa99 rs2
feature: Y317 p66 SHC1 s728 sa99 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK8_10-RIGHT__MAPK8_10-_re152
controller: MAP2K4 s995 sa219

NFKB1 p50 s1880 sa971 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NFKB1 (p50)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re585 801
type: Stoichiometry
physical entity: RHOA-GTP
stoichiometric coefficient: 1.0

Substance-P receptor
type: DnaReference
xref: PTHR46925:SF4
organism: Homo sapiens

ACAT1
type: DnaRegion
entity reference: ACAT1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

S221 RSK1 2 s1856 sa215 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 RSK1 2 s1856 sa215 rs5 S221
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=3.8909266156067464
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221

MEF2
type: Protein
entity reference: MEF2
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

00696
type: UnificationXref
id: MOD:00696
db: mod

PARTICIPANT STOICHIOMETRY re542 968
type: Stoichiometry
physical entity: PLA2
stoichiometric coefficient: 1.0

00695
type: UnificationXref
id: MOD:00695
db: mod

STATE_TRANSITION_LEFT__PI3,4,5_P3-RIGHT__PI4,5_P2-_re104
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re104 1132
participant stoichiometry: PARTICIPANT STOICHIOMETRY re104 1131
left: PI3,4,5-P3
interaction type: STATE_TRANSITION
right: PI4,5-P2

PARTICIPANT STOICHIOMETRY re542 967
type: Stoichiometry
physical entity: PLA2
stoichiometric coefficient: 1.0

GAS-REBP3
type: Protein
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PKCzeta-RIGHT__PKCzeta-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 918
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 919
left: PKCzeta
interaction type: STATE_TRANSITION
right: PKCzeta

PLA2
type: Protein
entity reference: PLA2
feature: S505 PLA2 s1871 sa825 rs2
feature: S727 PLA2 s1871 sa825 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Ca_CaM
type: Complex
component stoichiometry: Ca2 PLUS s2005 sa1003 STOICHIOMETRY ID COMPLEX
component stoichiometry: CaM s695 sa1002 STOICHIOMETRY ID COMPLEX
component: Ca2+
component: CaM
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s2004 csa84 417
feature: COMPLEX BINDING FEATURE s2004 csa84 415
cellular location: CELL

Y G17 s1417 sa559 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y G17 s1417 sa559 rs1 Y
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.7742892784837644

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_CDC42_GDP-RIGHT__GDP-_CDC42_GTP-_re78
controller: HRAS-GTP

TRANSPORT_LEFT__MMP7-RIGHT__MMP7-_re419
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re419 1199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re419 1200
left: MMP7
interaction type: TRANSPORT
right: MMP7

STATE_TRANSITION_LEFT__FAK2-RIGHT__FAK2-_re309
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re309 614
participant stoichiometry: PARTICIPANT STOICHIOMETRY re309 615
left: FAK2
interaction type: STATE_TRANSITION
right: FAK2

Gbeta
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa249 290
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Pre_pro_CCK_@_ER-RIGHT__Pro_CCK_@_TGN-_re302
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re302 634
participant stoichiometry: PARTICIPANT STOICHIOMETRY re302 633
left: Pre-pro CCK @ ER
interaction type: STATE_TRANSITION
right: Pro CCK @ TGN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IRS1-RIGHT__IRS1-_re99
controller: SRC @Galphaq

cGK 1
type: ProteinReference
xref: P07149
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.cGK 1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: cGMP-dependent protein kinase 1

UNKNOWN_CATALYSIS
type: Catalysis
controller: CCK1R

CRK
type: ProteinReference
xref: P07125
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CRK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Adapter molecule crk

MMP7
type: RnaRegion
entity reference: MMP7
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

uniprot P49674 76
type: UnificationXref
id: P49674
db: uniprot

STATE_TRANSITION_LEFT__BAX-RIGHT__BAX-_re563
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re563 892
participant stoichiometry: PARTICIPANT STOICHIOMETRY re563 893
left: BAX
interaction type: STATE_TRANSITION
right: BAX

STATE_TRANSITION_LEFT__FAK2-RIGHT__FAK2-_re313
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re313 592
participant stoichiometry: PARTICIPANT STOICHIOMETRY re313 591
left: FAK2
interaction type: STATE_TRANSITION
right: FAK2

Pancreatic enzyme secretion
type: Pathway

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SP1-RIGHT__SP1-_re195
controller: MAPK1/3

STATE_TRANSITION_LEFT__FAK2-RIGHT__FAK2-_re312
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re312 593
participant stoichiometry: PARTICIPANT STOICHIOMETRY re312 594
left: FAK2
interaction type: STATE_TRANSITION
right: FAK2

S136 BAD s1565 sa857 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S136
feature location: S136 BAD s1565 sa857 rs2 S136
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8079058030724882
comment: MODIFICATION_RESIDUE_NAME=S136

BCL2
type: Protein
entity reference: BCL2
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

IL8
type: RnaRegion
entity reference: IL8
cellular location: CELL
comment: SPECIES_TYPE=RNA

T261 MAP2K4 s995 sa219 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T261
feature location: T261 MAP2K4 s995 sa219 rs2 T261
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T261
comment: MODIFICATION_RESIDUE_ANGLE=5.61

STATE_TRANSITION_LEFT__MAPK1-RIGHT__MAPK1-_re153
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re153 945
participant stoichiometry: PARTICIPANT STOICHIOMETRY re153 946
left: MAPK1 s987 sa202
interaction type: STATE_TRANSITION
right: MAPK1

uniprot Q13541 93
type: UnificationXref
id: Q13541
db: uniprot

PRAS40
type: Protein
entity reference: PRAS40
feature: T246 PRAS40 s647 sa173 rs2
feature: S212 PRAS40 s647 sa173 rs3
feature: S221 PRAS40 s647 sa173 rs4
feature: S183 PRAS40 s647 sa173 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

uniprot P10145 51
type: UnificationXref
id: P10145
db: uniprot

PTHR45976:SF4
type: RelationshipXref
id: PTHR45976:SF4
db: PANTHER Family
relationship type: By Homology

BAX/MCL1 heterodimer
type: Complex
component stoichiometry: HOMODIMER ID 92STOICHIOMETRY ID COMPLEX
component stoichiometry: MCL1 s1568 sa968 STOICHIOMETRY ID COMPLEX
component: MCL1
component: BAX
feature: COMPLEX BINDING FEATURE s1969 csa80 377
feature: COMPLEX BINDING FEATURE s1969 csa80 375
cellular location: Mitochondria

IKKgamma
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1812 sa261 470
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y579 FAK2 s1203 sa519 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y579
feature location: Y579 FAK2 s1203 sa519 rs2 Y579
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y579
comment: MODIFICATION_RESIDUE_ANGLE=3.84

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Apoptosis
controller: Caspase-3

S338 RAF1 s1330 sa689 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S338
feature location: S338 RAF1 s1330 sa689 rs1 S338
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S338
comment: MODIFICATION_RESIDUE_ANGLE=1.5707963267948966

S338 RAF1 s1721 sa694 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S338
feature location: S338 RAF1 s1721 sa694 rs1 S338
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S338
comment: MODIFICATION_RESIDUE_ANGLE=1.5707963267948966

KNOWN_TRANSITION_OMITTED_LEFT__SHC1-RIGHT__p46_SHC1-_re56
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re56 715
participant stoichiometry: PARTICIPANT STOICHIOMETRY re56 716
left: SHC1
interaction type: KNOWN_TRANSITION_OMITTED
right: p46 SHC1

CCK
type: Protein
entity reference: CCK
feature: COMPLEX PARTICIPANT BINDING FEATURE s1779 sa948 436
feature: ACTIVE 13
feature: Y77 CCK s1779 sa948 rs1
feature: Y91 CCK s1779 sa948 rs2
feature: Y94 CCK s1779 sa948 rs3
cellular location: Endosome
comment: SPECIES_TYPE=PROTEIN

Cyclic AMP-dependent transcription factor ATF-2
type: ProteinReference
xref: PTHR19304:SF9
xref: uniprot P15336 166
organism: Homo sapiens

PAK
type: ProteinReference
xref: P07091
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PAK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Serine/threonine-protein kinase PAK 1

PTHR10155:SF3
type: RelationshipXref
id: PTHR10155:SF3
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__E_cadherin-_beta_catenin-RIGHT__E_cadherin_beta_catenin-_re370
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re370 484
participant stoichiometry: PARTICIPANT STOICHIOMETRY re370 483
participant stoichiometry: PARTICIPANT STOICHIOMETRY re370 485
left: beta-catenin
left: E-cadherin
interaction type: HETERODIMER_ASSOCIATION
right: E-cadherin/beta-catenin

STATE_TRANSITION_LEFT__MAPKAP_K2-RIGHT__MAPKAP_K2-_re573
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re573 851
participant stoichiometry: PARTICIPANT STOICHIOMETRY re573 850
left: MAPKAP-K2
interaction type: STATE_TRANSITION
right: MAPKAP-K2

S434 CCK2R s1369 sa563 rs12
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S434
feature location: S434 CCK2R s1369 sa563 rs12 S434
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.078526462630984
comment: MODIFICATION_RESIDUE_NAME=S434

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__JUN-RIGHT__JUN-_re209
controller: JUN+ATF2

Y94 Signal pre pro CCK s1187 sa495 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 Signal pre pro CCK s1187 sa495 rs3 Y94
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.48495384045865
comment: MODIFICATION_RESIDUE_NAME=Y94

Radiation-inducible immediate-early gene IEX-1
type: DnaReference
xref: PTHR16915:SF0
organism: Homo sapiens

TRANSPORT_LEFT__MOB1-RIGHT__MOB1-_re502
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re502 1112
participant stoichiometry: PARTICIPANT STOICHIOMETRY re502 1111
left: MOB1
interaction type: TRANSPORT
right: MOB1

Y438 CCK2R s1369 sa563 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y438
feature location: Y438 CCK2R s1369 sa563 rs5 Y438
comment: MODIFICATION_RESIDUE_NAME=Y438
comment: MODIFICATION_RESIDUE_ANGLE=4.421329661007988
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PTHR10179:SF80
type: RelationshipXref
id: PTHR10179:SF80
db: PANTHER Family
relationship type: By Homology

TFF1
type: RnaRegion
entity reference: TFF1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

TRANSPORT_LEFT__TFF2-RIGHT__TFF2-_re250
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re250 690
participant stoichiometry: PARTICIPANT STOICHIOMETRY re250 691
left: TFF2
interaction type: TRANSPORT
right: TFF2

AKT1
type: Protein
entity reference: AKT1
feature: ACTIVE 13
feature: T308 AKT1 s913 sa301 rs1
feature: S473 AKT1 s913 sa301 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s913 sa301 338
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

HRAS
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1804 sa67 456
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_CDC42_GDP-RIGHT__GDP-_CDC42_GTP-_re78
controller: CCK2R

E-cadherin
type: Protein
entity reference: E-cadherin
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Cell growth and proliferation
controller: CCND1

S207 MAP2K6 s997 sa224 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S207
feature location: S207 MAP2K6 s997 sa224 rs1 S207
comment: MODIFICATION_RESIDUE_NAME=S207
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8161980913738187

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__BCL2L1-_BAX-RIGHT__BAX_BCL2L1_heterodimer-_re559
controller: PAK1

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P19174 103
organism: Homo sapiens

FOXO1
type: Protein
entity reference: FOXO1
feature: ACTIVE 13
feature: S319 FOXO1 s1620 sa899 rs2
feature: S256 FOXO1 s1620 sa899 rs1
feature: T24 FOXO1 s1620 sa899 rs3
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Anti-apoptosis
controller: BIRC2

S710 PRKD2 s773 sa696 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S710
feature location: S710 PRKD2 s773 sa696 rs3 S710
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3074279375630917
comment: MODIFICATION_RESIDUE_NAME=S710

PTHR23220:SF4
type: RelationshipXref
id: PTHR23220:SF4
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__JUN-RIGHT__JUN-_re592
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re592 763
participant stoichiometry: PARTICIPANT STOICHIOMETRY re592 764
left: JUN
interaction type: TRANSPORT
right: JUN

Y580 FAK2 s1604 sa880 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y580
feature location: Y580 FAK2 s1604 sa880 rs3 Y580
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y580
comment: MODIFICATION_RESIDUE_ANGLE=0.75

PTHR46925:SF4
type: RelationshipXref
id: PTHR46925:SF4
db: PANTHER Family
relationship type: By Homology

GCG
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.GCG
comment: ENTITY_REFERENCE_NOTES=

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Atypical_PKC-RIGHT__Atypical_PKC-_re20
controller: CCK2R

CCK-CCK1R
type: Complex
component stoichiometry: CCK s1779 sa948 STOICHIOMETRY ID COMPLEX
component stoichiometry: CCK1R s1483 sa454 STOICHIOMETRY ID COMPLEX
component: CCK1R
component: CCK
feature: COMPLEX BINDING FEATURE s1163 csa39 435
feature: COMPLEX BINDING FEATURE s1163 csa39 433
cellular location: Endosome

PTHR46559:SF1
type: RelationshipXref
id: PTHR46559:SF1
db: PANTHER Family
relationship type: By Homology

CD38
type: ProteinReference
xref: P07204
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CD38
member entity reference: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Dynamin
type: Protein
entity reference: Dynamin
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y91 CCK s1780 sa949 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y91
feature location: Y91 CCK s1780 sa949 rs2 Y91
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7668909901804244
comment: MODIFICATION_RESIDUE_NAME=Y91
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

BAX
type: Protein
entity reference: BAX
feature: ACTIVE 13

RAF1
type: ProteinReference
xref: P07085
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RAF1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: RAF proto-oncogene serine/threonine-protein kinase

KNOWN_TRANSITION_OMITTED_LEFT__SRC_@Galphaq-RIGHT__p62_SRC-_re55
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re55 720
participant stoichiometry: PARTICIPANT STOICHIOMETRY re55 719
left: SRC @Galphaq
interaction type: KNOWN_TRANSITION_OMITTED
right: p62 SRC

uniprot P04792 21
type: UnificationXref
id: P04792
db: uniprot

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__CALCA-RIGHT__CALCA-_re503
controller: NFKB1/RELA heterodimer

Y861 FAK1 s668 sa118 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y861
feature location: Y861 FAK1 s668 sa118 rs5 Y861
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.75
comment: MODIFICATION_RESIDUE_NAME=Y861

S876 PRKD2 s774 sa735 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S876
feature location: S876 PRKD2 s774 sa735 rs1 S876
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.583002134385839
comment: MODIFICATION_RESIDUE_NAME=S876
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

TRANSCRIPTION_LEFT__MMP9-RIGHT__MMP9-_re420
type: TemplateReaction
product: MMP9
xref: TRANSCRIPTION
participant: MMP9
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

TRANSPORT_LEFT__CCK2R-RIGHT__CCK2R-_re334
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re334 552
participant stoichiometry: PARTICIPANT STOICHIOMETRY re334 551
left: CCK2R
interaction type: TRANSPORT
right: CCK2R

PTHR10179:SF42
type: RelationshipXref
id: PTHR10179:SF42
db: PANTHER Family
relationship type: By Homology

TRANSCRIPTION_LEFT__FOS-RIGHT__FOS-_re206
type: TemplateReaction
product: FOS
xref: TRANSCRIPTION
participant: FOS
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

T SOS1 s946 sa273 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T SOS1 s946 sa273 rs1 T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_ANGLE=0.8611146530060259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

FK506
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=DRUG

Heat shock protein beta-1
type: ProteinReference
xref: uniprot P04792 21
xref: PTHR45640:SF7
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re350 539
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re601 884
type: Stoichiometry
physical entity: p38MAPK s998 sa227
stoichiometric coefficient: 1.0

CCK1R (inactive)
type: Complex
component stoichiometry: CCK s1911 sa947 STOICHIOMETRY ID COMPLEX
component stoichiometry: CCK1R s866 sa458 STOICHIOMETRY ID COMPLEX
component: CCK s1911 sa947
component: CCK1R
feature: COMPLEX BINDING FEATURE s1998 csa41 445
feature: COMPLEX BINDING FEATURE s1998 csa41 443
cellular location: CELL

A-Raf
type: Protein
entity reference: A-Raf
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION_LEFT__HDC-RIGHT__HDC-_re437
type: TemplateReaction
product: HDC
xref: TRANSCRIPTION
participant: HDC
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

CD38
type: Protein
entity reference: CD38
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re312 593
type: Stoichiometry
physical entity: FAK2
stoichiometric coefficient: 1.0

TRANSPORT
type: RelationshipTypeVocabulary

TRANSPORT_LEFT__SNAI1-RIGHT__SNAI1-_re376
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re376 1217
participant stoichiometry: PARTICIPANT STOICHIOMETRY re376 1216
left: SNAI1
interaction type: TRANSPORT
right: SNAI1

PARTICIPANT STOICHIOMETRY re312 594
type: Stoichiometry
physical entity: FAK2
stoichiometric coefficient: 1.0

MAP3K11
type: Protein
entity reference: MAP3K11
feature: S281 MAP3K11 s994 sa218 rs2
feature: T277 MAP3K11 s994 sa218 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 11

PARTICIPANT STOICHIOMETRY re350 540
type: Stoichiometry
physical entity: NAADP
stoichiometric coefficient: 1.0

Interleukin-8
type: DnaReference
xref: PTHR10179:SF42
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re146 979
type: Stoichiometry
physical entity: RSK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re490 1029
type: Stoichiometry
physical entity: CCK-58
stoichiometric coefficient: 1.0

ACAT1
type: RnaRegion
entity reference: ACAT1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

S218 MAP2K1 s822 sa204 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S218
feature location: S218 MAP2K1 s822 sa204 rs1 S218
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.577710244558395
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S218

PARTICIPANT STOICHIOMETRY re24 859
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re670 595
type: Stoichiometry
physical entity: NFAT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re670 596
type: Stoichiometry
physical entity: NFAT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 858
type: Stoichiometry
physical entity: Atypical PKC
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: Control
xref: STATE TRANSITION
controlled: Migration
controller: FAK2-SRC complex

PARTICIPANT STOICHIOMETRY re601 885
type: Stoichiometry
physical entity: AKT1-PIP3
stoichiometric coefficient: 1.0

S SOS1 s894 sa270 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S SOS1 s894 sa270 rs2 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.511144255404544

Y460 CAS s765 sa116 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y460
feature location: Y460 CAS s765 sa116 rs4 Y460
comment: MODIFICATION_RESIDUE_NAME=Y460
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.426319326209974

AP1 (FOS+JUN)
type: Complex
component stoichiometry: FOS s1040 sa339 STOICHIOMETRY ID COMPLEX
component stoichiometry: JUN s1041 sa340 STOICHIOMETRY ID COMPLEX
component: JUN
component: FOS
feature: COMPLEX BINDING FEATURE s1983 csa34 213
feature: COMPLEX BINDING FEATURE s1983 csa34 215
cellular location: NUCLEUS

Dynamin
type: ProteinReference
xref: P07100
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Dynamin
member entity reference: Dynamin-1

T359 RSK1 2 s1856 sa215 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T359
feature location: T359 RSK1 2 s1856 sa215 rs2 T359
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=T359
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7908334448050431

PARTICIPANT STOICHIOMETRY re490 1030
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re146 980
type: Stoichiometry
physical entity: RSK1 2 s539 sa214
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 914
type: Stoichiometry
physical entity: Conventional PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 915
type: Stoichiometry
physical entity: PKCalpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re537 998
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re537 997
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 2.0

T222 MAPKAP K2 s1584 sa871 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T222
feature location: T222 MAPKAP K2 s1584 sa871 rs1 T222
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T222
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8539933973255165

KNOWN_TRANSITION_OMITTED_LEFT__BCL2-RIGHT__BCL2-_re635
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re635 737
participant stoichiometry: PARTICIPANT STOICHIOMETRY re635 738
left: BCL2
interaction type: KNOWN_TRANSITION_OMITTED
right: BCL2

Y402 FAK2 s1204 sa520 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y402
feature location: Y402 FAK2 s1204 sa520 rs1 Y402
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.37
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y402

PARTICIPANT STOICHIOMETRY re47 766
type: Stoichiometry
physical entity: G17 - Gly
stoichiometric coefficient: 1.0

MEN1
type: Protein
entity reference: MEN1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__TACR1-RIGHT__TACR1-_re511
controller: AP1 (FOS+JUN)

S434 CCK2R s1660 sa22 rs12
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S434
feature location: S434 CCK2R s1660 sa22 rs12 S434
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.078526462630984
comment: MODIFICATION_RESIDUE_NAME=S434

S307 CCK1R s1672 sa449 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S307
feature location: S307 CCK1R s1672 sa449 rs3 S307
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.912135572113799
comment: MODIFICATION_RESIDUE_NAME=S307

HETERODIMER_ASSOCIATION_LEFT__BCL2L1-_BAD-RIGHT__BAD_BCL2L1_heterodimer-_re580
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re580 823
participant stoichiometry: PARTICIPANT STOICHIOMETRY re580 822
participant stoichiometry: PARTICIPANT STOICHIOMETRY re580 821
left: BCL2L1
left: BAD
interaction type: HETERODIMER_ASSOCIATION
right: BAD/BCL2L1 heterodimer

PARTICIPANT STOICHIOMETRY re47 765
type: Stoichiometry
physical entity: G34-Gly
stoichiometric coefficient: 1.0

T439 CCK2R s1688 sa565 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T439
feature location: T439 CCK2R s1688 sa565 rs6 T439
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.751588888718252
comment: MODIFICATION_RESIDUE_NAME=T439

S253 FOXO3 s1991 sa995 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S253
feature location: S253 FOXO3 s1991 sa995 rs2 S253
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S253
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4291919098540697

PARTICIPANT STOICHIOMETRY re451 1156
type: Stoichiometry
physical entity: JUN+ATF2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re451 1155
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re142 988
type: Stoichiometry
physical entity: MAPK3
stoichiometric coefficient: 1.0

T308 AKT1 s908 sa303 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T308
feature location: T308 AKT1 s908 sa303 rs1 T308
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T308
comment: MODIFICATION_RESIDUE_ANGLE=0.8191115980742862

ITGB1
type: DnaRegion
entity reference: ITGB1
cellular location: CELL
comment: SPECIES_TYPE=GENE

beta-catenin/TCF-4
type: Complex
component stoichiometry: beta catenin s1315 sa638 STOICHIOMETRY ID COMPLEX
component stoichiometry: TCF7L2 s1875 sa342 STOICHIOMETRY ID COMPLEX
component: beta-catenin
component: TCF7L2
feature: COMPLEX BINDING FEATURE s1978 csa35 451
feature: COMPLEX BINDING FEATURE s1978 csa35 453
cellular location: NUCLEUS

Pro HBEGF
type: ProteinReference
xref: P07182
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Pro HBEGF
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Q99075

S221 HuR s1007 sa727 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 HuR s1007 sa727 rs2 S221
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.58
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221

KNOWN_TRANSITION_OMITTED_LEFT__HuR_COX2-RIGHT__COX2-_re433
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re433 1181
participant stoichiometry: PARTICIPANT STOICHIOMETRY re433 1180
left: HuR-COX2
interaction type: KNOWN_TRANSITION_OMITTED
right: COX2

PARTICIPANT STOICHIOMETRY re451 1154
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re461 1139
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re142 987
type: Stoichiometry
physical entity: MAPK3
stoichiometric coefficient: 1.0

sa436_degraded
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=DEGRADED

S497 9 RAF1 s731 sa687 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S497 9
feature location: S497 9 RAF1 s731 sa687 rs8 S497 9
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=6.261510357865046
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S497/9

PARTICIPANT STOICHIOMETRY re461 1140
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 2.0

T505 PKCdelta s1709 sa26 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T505
feature location: T505 PKCdelta s1709 sa26 rs1 T505
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.6716181477744779
comment: MODIFICATION_RESIDUE_NAME=T505

CXCL2
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.CXCL2
comment: ENTITY_REFERENCE_NOTES=

PTHR10179:SF69
type: RelationshipXref
id: PTHR10179:SF69
db: PANTHER Family
relationship type: By Homology

S657 PKCalpha s1824 sa17 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S657
feature location: S657 PKCalpha s1824 sa17 rs1 S657
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S657
comment: MODIFICATION_RESIDUE_ANGLE=0.8193686721949158

4E-BP1
type: Protein
entity reference: 4E-BP1
feature: 4E BP1 s652 sa168 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

3-phosphoinositide-dependent protein kinase 1
type: ProteinReference
xref: PTHR24356:SF163
xref: uniprot O15530 30
organism: Homo sapiens

STATE_TRANSITION_LEFT__CDC42_GTP-RIGHT__Pi-_CDC42_GDP-_re79
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re79 641
participant stoichiometry: PARTICIPANT STOICHIOMETRY re79 639
participant stoichiometry: PARTICIPANT STOICHIOMETRY re79 640
left: CDC42-GTP
interaction type: STATE_TRANSITION
right: CDC42-GDP
right: Pi

PTHR48015:SF20
type: RelationshipXref
id: PTHR48015:SF20
db: PANTHER Family
relationship type: By Homology

By Homology
type: RelationshipTypeVocabulary

S264 CCK1R s1485 sa456 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S264
feature location: S264 CCK1R s1485 sa456 rs2 S264
comment: MODIFICATION_RESIDUE_ANGLE=4.459733321203526
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S264

PTHR10454:SF198
type: RelationshipXref
id: PTHR10454:SF198
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re424 1186
type: Stoichiometry
physical entity: CCND1
stoichiometric coefficient: 1.0

Y238 CCK2R s1235 sa558 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y238
feature location: Y238 CCK2R s1235 sa558 rs7 Y238
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789
comment: MODIFICATION_RESIDUE_NAME=Y238

PARTICIPANT STOICHIOMETRY re424 1187
type: Stoichiometry
physical entity: CCND1
stoichiometric coefficient: 1.0

PTHR46768:SF1
type: RelationshipXref
id: PTHR46768:SF1
db: PANTHER Family
relationship type: By Homology

PTHR10728:SF13
type: RelationshipXref
id: PTHR10728:SF13
db: PANTHER Family
relationship type: By Homology

PTHR47616:SF1
type: RelationshipXref
id: PTHR47616:SF1
db: PANTHER Family
relationship type: By Homology

mTORC1 complex
type: Complex
component stoichiometry: mTOR s644 sa311 STOICHIOMETRY ID COMPLEX
component stoichiometry: RPTOR s643 sa312 STOICHIOMETRY ID COMPLEX
component stoichiometry: mLST8 s922 sa313 STOICHIOMETRY ID COMPLEX
component: mTOR
component: RPTOR
component: mLST8 s922 sa313
feature: COMPLEX BINDING FEATURE s920 csa26 177
feature: COMPLEX BINDING FEATURE s920 csa26 175
feature: COMPLEX BINDING FEATURE s920 csa26 179
cellular location: CELL

PARTICIPANT STOICHIOMETRY re189 819
type: Stoichiometry
physical entity: ELK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re612 835
type: Stoichiometry
physical entity: Galpha q complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re612 834
type: Stoichiometry
physical entity: Gbeta/gamma
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__beta_catenin-RIGHT__beta_catenin-_re374
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re374 1220
participant stoichiometry: PARTICIPANT STOICHIOMETRY re374 1221
left: beta-catenin
interaction type: TRANSPORT
right: beta-catenin

PARTICIPANT STOICHIOMETRY re612 837
type: Stoichiometry
physical entity: G Protein complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re612 836
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

Gbeta s20 sa249 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

uniprot Q02080 161
type: UnificationXref
id: Q02080
db: uniprot

Serine/threonine-protein kinase D2
type: ProteinReference
xref: PTHR22968:SF12
xref: uniprot Q9BZL6 151
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAP3K14-RIGHT__MAP3K14-_re37
controller: TAK1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ELK1-RIGHT__ELK1-_re189
controller: MAPK1/3

PARTICIPANT STOICHIOMETRY re189 820
type: Stoichiometry
physical entity: ELK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re464 1128
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PAK1-RIGHT__PAK1-_re82
controller: PI3K Class I

GEF
type: Protein
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

LYN
type: Protein
entity reference: LYN
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Cytochrome_C-RIGHT__Cytochrome_C-_re633
controller: BAD/BCL2L1 heterodimer

MYC
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.MYC
comment: ENTITY_REFERENCE_NOTES=

PTHR24070:SF264
type: RelationshipXref
id: PTHR24070:SF264
db: PANTHER Family
relationship type: By Homology

S363 RSK1 2 s539 sa214 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S363
feature location: S363 RSK1 2 s539 sa214 rs1 S363
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=2.378634437717986
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S363

S43 RAF1 s1330 sa689 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S43
feature location: S43 RAF1 s1330 sa689 rs6 S43
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.908388522052502
comment: MODIFICATION_RESIDUE_NAME=S43

S133 FOS s1040 sa339 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S133
feature location: S133 FOS s1040 sa339 rs5 S133
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S133
comment: MODIFICATION_RESIDUE_ANGLE=0.76

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ICER-RIGHT__ICER-_re278
controller: CREB1

PTHR23235:SF16
type: RelationshipXref
id: PTHR23235:SF16
db: PANTHER Family
relationship type: By Homology

TRAF6
type: ProteinReference
xref: P07111
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.TRAF6
comment: ENTITY_REFERENCE_NOTES=
member entity reference: TNF receptor-associated factor 6

REG1A
type: DnaRegion
entity reference: REG1A
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY re3 493
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 492
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

Y861 FAK1 s1450 sa782 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y861
feature location: Y861 FAK1 s1450 sa782 rs5 Y861
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.75
comment: MODIFICATION_RESIDUE_NAME=Y861

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HRAS_GDP-_GTP-RIGHT__HRAS_GTP-_GDP-_re156
controller: p52SHC1-GRB2-SOS1

Gastrin/cholecystokinin type B receptor
type: ProteinReference
xref: uniprot P32239 22
xref: PTHR24243:SF45
organism: Homo sapiens

KNOWN_TRANSITION_OMITTED_LEFT__Atypical_PKC-RIGHT__PKCzeta-_re14
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 913
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 912
left: Atypical PKC
interaction type: KNOWN_TRANSITION_OMITTED
right: PKCzeta

PARTICIPANT STOICHIOMETRY re575 847
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

A-Raf
type: Protein
entity reference: A-Raf
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re575 846
type: Stoichiometry
physical entity: p60 SRC
stoichiometric coefficient: 1.0

BCL2 s1562 sa856 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BCL2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__G34_Gly-RIGHT__G17___Gly-_re47
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 765
participant stoichiometry: PARTICIPANT STOICHIOMETRY re47 766
left: G34-Gly
interaction type: STATE_TRANSITION
right: G17 - Gly

p85
type: Protein
entity reference: p85
feature: COMPLEX PARTICIPANT BINDING FEATURE s885 sa298 202
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

MAPK7
type: Protein
entity reference: MAPK7
feature: ACTIVE 13
feature: T219 MAPK7 s1972 sa990 rs1
feature: Y221 MAPK7 s1972 sa990 rs2

S473 AKT1 s908 sa303 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S473
feature location: S473 AKT1 s908 sa303 rs2 S473
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S473
comment: MODIFICATION_RESIDUE_ANGLE=5.615596868291756

CD38
type: Protein
entity reference: CD38
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

SOS1
type: ProteinReference
xref: P07061
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.SOS1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Son of sevenless homolog 1

S847 NOS1 s1267 sa628 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S847
feature location: S847 NOS1 s1267 sa628 rs1 S847
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.399827721492203
comment: MODIFICATION_RESIDUE_NAME=S847

S82 CCK2R s1369 sa563 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S82
feature location: S82 CCK2R s1369 sa563 rs2 S82
comment: MODIFICATION_RESIDUE_ANGLE=2.827433388230814
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S82

MAP2K1
type: Protein
entity reference: MAP2K1 PROTEIN
feature: S222 MAP2K1 s821 sa207 rs2
feature: S218 MAP2K1 s821 sa207 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MAP3K11-RIGHT__MAP3K11-_re149
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re149 971
participant stoichiometry: PARTICIPANT STOICHIOMETRY re149 972
left: MAP3K11
interaction type: STATE_TRANSITION
right: MAP3K11

UNKNOWN_CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Beta_arrestin_1_2-_CCK2R-RIGHT__active_CCK2R_beta_arrestin_complex-_re331
controller: RGS2

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re407
controller: AKT1-PIP3

Y204 MAPK1 s987 sa202 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y204
feature location: Y204 MAPK1 s987 sa202 rs2 Y204
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.51
comment: MODIFICATION_RESIDUE_NAME=Y204

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
type: ProteinReference
xref: uniprot P28907 32
xref: PTHR10912:SF5
organism: Homo sapiens

NFKB1 (p50)
type: Protein
feature: NFKB1 p50 s1883 sa973 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1883 sa973 304
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__4E_BP1_EIF4E_complex-RIGHT__4E_BP1-_EIF4E-_re118
controller: mTORC1 complex

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PAK1-RIGHT__PAK1-_re81
control type: ACTIVATION
controller: RAC1-GTP

JUN s1050 sa349 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JUN s1050 sa349
stoichiometric coefficient: 1.0

S222 MAP2K2 s988 sa206 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S222
feature location: S222 MAP2K2 s988 sa206 rs1 S222
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S222

Serine/threonine-protein kinase D1
type: ProteinReference
xref: uniprot Q15139 152
xref: PTHR22968:SF9
organism: Homo sapiens

PTHR23235:SF41
type: RelationshipXref
id: PTHR23235:SF41
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re464 1127
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

PTHR23235:SF42
type: RelationshipXref
id: PTHR23235:SF42
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re621 792
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re621 791
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

uniprot Q13153 159
type: UnificationXref
id: Q13153
db: uniprot

TCF7L2 s1875 sa342 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TCF7L2
stoichiometric coefficient: 1.0

PTHR45627:SF12
type: RelationshipXref
id: PTHR45627:SF12
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re241 718
type: Stoichiometry
physical entity: HBEGF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re241 717
type: Stoichiometry
physical entity: HBEGF
stoichiometric coefficient: 1.0

Y418 SRC @Galphaq s718 sa94 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y418
feature location: Y418 SRC @Galphaq s718 sa94 rs3 Y418
comment: MODIFICATION_RESIDUE_NAME=Y418
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3192345766207003

S374 FOS s1858 sa234 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S374
feature location: S374 FOS s1858 sa234 rs6 S374
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=1.5878173396239432
comment: MODIFICATION_RESIDUE_NAME=S374

Y G34 s11 sa85 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y G34 s11 sa85 rs1 Y
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8196755025969574
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y

STATE_TRANSITION_LEFT__Atypical_PKC-RIGHT__Atypical_PKC-_re20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 871
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 870
left: Atypical PKC
interaction type: STATE_TRANSITION
right: Atypical PKC

SRC @Galphaq
type: ProteinReference
xref: P07163
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.SRC_br_@G_alpha__sub_q
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Proto-oncogene tyrosine-protein kinase Src

IKKgamma
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1812 sa258 464
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

RELA (p65)
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1881 sa972 356
feature: RELA p65 s1881 sa972 rs1
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re76 650
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re76 651
type: Stoichiometry
physical entity: RAC1-GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re76 649
type: Stoichiometry
physical entity: RAC1-GDP
stoichiometric coefficient: 1.0

p110 s936 sa297 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p110 s936 sa297
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Complex__GRB2_SOS1_-_p46_SHC1-RIGHT__p46SHC1_GRB2_SOS1-_re68
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re68 675
participant stoichiometry: PARTICIPANT STOICHIOMETRY re68 677
participant stoichiometry: PARTICIPANT STOICHIOMETRY re68 676
left: p46 SHC1
left: Complex (GRB2/SOS1)
interaction type: HETERODIMER_ASSOCIATION
right: p46SHC1-GRB2-SOS1

uniprot P08047 118
type: UnificationXref
id: P08047
db: uniprot

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Gastric mucosa differentiation
controller: TFF2

TAK1
type: ProteinReference
xref: P07170
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.TAK1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Nuclear receptor subfamily 2 group C member 2

uniprot P16220 65
type: UnificationXref
id: P16220
db: uniprot

S42 FOS s1040 sa339 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S42
feature location: S42 FOS s1040 sa339 rs3 S42
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S42
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

PARTICIPANT STOICHIOMETRY re574 848
type: Stoichiometry
physical entity: HSP27
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re577 845
type: Stoichiometry
physical entity: BCL2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re574 849
type: Stoichiometry
physical entity: HSP27
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re577 843
type: Stoichiometry
physical entity: BAD/BCL2 heterodimer
stoichiometric coefficient: 1.0

PTHR18919:SF156
type: RelationshipXref
id: PTHR18919:SF156
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re577 844
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__HBEGF-RIGHT__HBEGF-_re240
type: TemplateReaction
product: HBEGF
xref: TRANSCRIPTION
participant: HBEGF
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

Y527 SRC @Galphaq s1769 sa881 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 SRC @Galphaq s1769 sa881 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.585857905576321
comment: MODIFICATION_RESIDUE_NAME=Y527

PI3K Class I
type: Complex
component stoichiometry: p85 s934 sa296 STOICHIOMETRY ID COMPLEX
component stoichiometry: p110 s936 sa297 STOICHIOMETRY ID COMPLEX
component: p85
component: p110 s936 sa297
feature: COMPLEX BINDING FEATURE s984 csa32 205
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s984 csa32 207
feature: COMPLEX PARTICIPANT BINDING FEATURE s984 csa32 430
cellular location: CELL

T654 EGFR s727 sa266 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T654
feature location: T654 EGFR s727 sa266 rs1 T654
comment: MODIFICATION_RESIDUE_ANGLE=2.9442758736229466
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T654

PARTICIPANT STOICHIOMETRY re76 652
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Y966 JAK2 s1633 sa153 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y966
feature location: Y966 JAK2 s1633 sa153 rs2 Y966
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y966
comment: MODIFICATION_RESIDUE_ANGLE=5.53026601520083

14-3-3 beta/alpha
type: ProteinReference
xref: P07038
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.14-3-3_br__beta_/_alpha_
member entity reference: 14-3-3 protein beta/alpha

PTHR11793:SF10
type: RelationshipXref
id: PTHR11793:SF10
db: PANTHER Family
relationship type: By Homology

IEX1
type: ProteinReference
xref: P07092
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.IEX1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Radiation-inducible immediate-early gene IEX-1

BCL2
type: Protein
entity reference: BCL2
feature: ACTIVE 13
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re103 1135
type: Stoichiometry
physical entity: PI4,5-P2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re103 1136
type: Stoichiometry
physical entity: PI3,4,5-P3
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Novel_PKC-RIGHT__PKCdelta-_re15
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 911
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 910
left: Novel PKC
interaction type: KNOWN_TRANSITION_OMITTED
right: PKCdelta

PARTICIPANT STOICHIOMETRY re582 811
type: Stoichiometry
physical entity: FOXO3
stoichiometric coefficient: 1.0

HuR s1075 sa730 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HuR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re582 812
type: Stoichiometry
physical entity: FOXO3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re242 714
type: Stoichiometry
physical entity: Pro HBEGF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re242 713
type: Stoichiometry
physical entity: HBEGF
stoichiometric coefficient: 1.0

E-cadherin
type: RnaRegion
entity reference: E-cadherin
cellular location: CELL
comment: SPECIES_TYPE=RNA

S264 CCK1R s1672 sa775 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S264
feature location: S264 CCK1R s1672 sa775 rs2 S264
comment: MODIFICATION_RESIDUE_ANGLE=4.459733321203526
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S264

CCK1R
type: Protein
feature: S307 CCK1R s1672 sa449 rs3
feature: S260 CCK1R s1672 sa449 rs1
feature: S430 CCK1R s1672 sa449 rs4
feature: S264 CCK1R s1672 sa449 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y221 MAPK7 s1971 sa989 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y221
feature location: Y221 MAPK7 s1971 sa989 rs2 Y221
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=Y221
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_TYPE=residue

S657 PKCalpha s1994 sa25 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S657
feature location: S657 PKCalpha s1994 sa25 rs1 S657
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S657
comment: MODIFICATION_RESIDUE_ANGLE=0.8193686721949158

STATE_TRANSITION_LEFT__BAD_BCL2L1_heterodimer-RIGHT__BAD_BCL2L1_heterodimer-_re578
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re578 842
participant stoichiometry: PARTICIPANT STOICHIOMETRY re578 841
left: BAD/BCL2L1 heterodimer
interaction type: STATE_TRANSITION
right: BAD/BCL2L1 heterodimer

PKCtheta
type: ProteinReference
xref: P07140
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PKC_theta_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein kinase C theta type

STATE_TRANSITION_LEFT__Progastrin_@Golgi-RIGHT__G34_Gly-_re479
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re479 1083
participant stoichiometry: PARTICIPANT STOICHIOMETRY re479 1082
left: Progastrin @Golgi
interaction type: STATE_TRANSITION
right: G34-Gly

MMP3
type: ProteinReference
xref: P07105
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MMP3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Stromelysin-1

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__mTORC1_complex-RIGHT__mTORC1_complex-_re116
control type: INHIBITION
controller: Rapamycin

S272 MAPKAP K2 s1583 sa870 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S272
feature location: S272 MAPKAP K2 s1583 sa870 rs2 S272
comment: MODIFICATION_RESIDUE_NAME=S272
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.33

PARTICIPANT STOICHIOMETRY re49 760
type: Stoichiometry
physical entity: HBEGF
stoichiometric coefficient: 1.0

4E BP1 s964 sa315 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 4E-BP1
stoichiometric coefficient: 1.0

CCK2R s1410 sa568 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CCK2R
stoichiometric coefficient: 1.0

S154 CCK2R s1235 sa558 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S154
feature location: S154 CCK2R s1235 sa558 rs3 S154
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.234636338452209
comment: MODIFICATION_RESIDUE_NAME=S154

KNOWN_TRANSITION_OMITTED_LEFT__Conventional_PKC-RIGHT__PKCbeta-_re178
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re178 856
participant stoichiometry: PARTICIPANT STOICHIOMETRY re178 857
left: Conventional PKC
interaction type: KNOWN_TRANSITION_OMITTED
right: PKCbeta

T491 RAF1 s731 sa687 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T491
feature location: T491 RAF1 s731 sa687 rs4 T491
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T491
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.3986264000533355

DISSOCIATION_LEFT__PI4,5_P2-RIGHT__DAG-_IP3-_re2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 496
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 495
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 494
left: PI4,5 P2 s35 sa19
interaction type: DISSOCIATION
right: IP3
right: DAG

Y764 CAS s766 sa287 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y764
feature location: Y764 CAS s766 sa287 rs2 Y764
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y764
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7892481543944946

RICTOR
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s960 sa318 316
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

s785
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=DEGRADED

PAI1
type: DnaRegionReference
member entity reference: Plasminogen activator inhibitor 1
xref: G07281
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.PAI1
comment: ENTITY_REFERENCE_NOTES=

S374 FOS s202 sa233 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S374
feature location: S374 FOS s202 sa233 rs6 S374
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=1.5878173396239432
comment: MODIFICATION_RESIDUE_NAME=S374

PARTICIPANT STOICHIOMETRY re49 759
type: Stoichiometry
physical entity: Pro HBEGF
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__FOS-RIGHT__FOS-_re464
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re464 1127
participant stoichiometry: PARTICIPANT STOICHIOMETRY re464 1128
left: FOS
interaction type: TRANSPORT
right: FOS

PARTICIPANT STOICHIOMETRY re116 1091
type: Stoichiometry
physical entity: mTORC1 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re116 1092
type: Stoichiometry
physical entity: mTORC1 complex
stoichiometric coefficient: 1.0

Ggamma
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa250 292
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S222 MAP2K2 s824 sa205 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S222
feature location: S222 MAP2K2 s824 sa205 rs1 S222
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S222

PARTICIPANT STOICHIOMETRY re10 923
type: Stoichiometry
physical entity: PKCeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 922
type: Stoichiometry
physical entity: PKCeta
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__TFF2-RIGHT__TFF2-_re245
type: TemplateReaction
product: TFF2
xref: TRANSCRIPTION
participant: TFF2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

FAK2-SRC-CRK complex
type: Complex
component stoichiometry: SRC @Galphaq s1894 sa976 STOICHIOMETRY ID COMPLEX
component stoichiometry: CRK s1893 sa977 STOICHIOMETRY ID COMPLEX
component stoichiometry: FAK2 s1892 sa975 STOICHIOMETRY ID COMPLEX
component: CRK
component: SRC @Galphaq
component: FAK2
feature: COMPLEX BINDING FEATURE s1949 csa72 391
feature: COMPLEX BINDING FEATURE s1949 csa72 389
feature: COMPLEX BINDING FEATURE s1949 csa72 387
cellular location: CELL

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re364
controller: CK1

IP3R s1549 sa7 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3744879256752047
comment: MODIFICATION_RESIDUE_NAME=

Y861 FAK1 s669 sa111 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y861
feature location: Y861 FAK1 s669 sa111 rs5 Y861
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.75
comment: MODIFICATION_RESIDUE_NAME=Y861

PAI2
type: DnaRegionReference
member entity reference: Plasminogen activator inhibitor 2
xref: G07270
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.PAI2
comment: ENTITY_REFERENCE_NOTES=

uniprot P49116 117
type: UnificationXref
id: P49116
db: uniprot

STATE_TRANSITION_LEFT__G34_Gly-RIGHT__G34-_re48
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re48 761
participant stoichiometry: PARTICIPANT STOICHIOMETRY re48 762
left: G34-Gly
interaction type: STATE_TRANSITION
right: G34

SRC @Galphaq s1894 sa976 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: Control
xref: STATE TRANSITION
controlled: Survival
controller: FAK2-SRC complex

p190RhoGEF
type: ProteinReference
xref: P07157
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p190RhoGEF
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Rho guanine nucleotide exchange factor 28

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HDAC7-RIGHT__HDAC7-_re447
controller: PRKD2

PARTICIPANT STOICHIOMETRY re147 978
type: Stoichiometry
physical entity: PDPK1
stoichiometric coefficient: 1.0

T491 RAF1 s1330 sa689 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T491
feature location: T491 RAF1 s1330 sa689 rs4 T491
comment: MODIFICATION_RESIDUE_NAME=T491
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.3986264000533355

PARTICIPANT STOICHIOMETRY re65 688
type: Stoichiometry
physical entity: Complex (GRB2/SOS1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re147 977
type: Stoichiometry
physical entity: PDPK1
stoichiometric coefficient: 1.0

S SOS1 s946 sa273 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S SOS1 s946 sa273 rs2 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.511144255404544

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p52_SHC1-RIGHT__p52_SHC1-_re59
controller: PKCepsilon

PARTICIPANT STOICHIOMETRY re65 689
type: Stoichiometry
physical entity: Complex (GRB2/SOS1)
stoichiometric coefficient: 1.0

Y91 Signal pre pro CCK s1187 sa495 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y91
feature location: Y91 Signal pre pro CCK s1187 sa495 rs2 Y91
comment: MODIFICATION_RESIDUE_NAME=Y91
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7266268722588637

HETERODIMER_ASSOCIATION_LEFT__BCL2L1-_BAX-RIGHT__BAX_BCL2L1_heterodimer-_re559
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re559 932
participant stoichiometry: PARTICIPANT STOICHIOMETRY re559 930
participant stoichiometry: PARTICIPANT STOICHIOMETRY re559 931
left: BCL2L1
left: BAX
interaction type: HETERODIMER_ASSOCIATION
right: BAX/BCL2L1 heterodimer

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_RAF___RAF1-RIGHT__c_RAF___RAF1-_re173
controller: PKC

HETERODIMER_ASSOCIATION_LEFT__CRK-_FAK2_SRC_complex-RIGHT__FAK2_SRC_CRK_complex-_re318
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re318 585
participant stoichiometry: PARTICIPANT STOICHIOMETRY re318 586
participant stoichiometry: PARTICIPANT STOICHIOMETRY re318 587
left: CRK
left: FAK2-SRC complex
interaction type: HETERODIMER_ASSOCIATION
right: FAK2-SRC-CRK complex

RELA p65 s1884 sa974 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=0.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot O60507 113
type: UnificationXref
id: O60507
db: uniprot

Y204 MAPK1 s831 sa201 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y204
feature location: Y204 MAPK1 s831 sa201 rs2 Y204
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.51
comment: MODIFICATION_RESIDUE_NAME=Y204

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IkB_kinase_complex-RIGHT__IkB_kinase_complex-_re38
controller: PKCdelta

PARTICIPANT STOICHIOMETRY re465 1125
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re465 1126
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 2.0

RELA p65 s1881 sa972 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

TRANSCRIPTION_LEFT__ITGB1-RIGHT__ITGB1-_re588
type: TemplateReaction
product: ITGB1
xref: TRANSCRIPTION
participant: ITGB1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Protein synthesis
controller: RPS6

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot P42338 40
organism: Homo sapiens

CCK2R
type: Protein
entity reference: CCK2R
feature: S82 CCK2R s1660 sa22 rs2
feature: S437 CCK2R s1660 sa22 rs4
feature: S442 CCK2R s1660 sa22 rs10
feature: T443 CCK2R s1660 sa22 rs11
feature: Y238 CCK2R s1660 sa22 rs7
feature: S154 CCK2R s1660 sa22 rs3
feature: ACTIVE 13
feature: S434 CCK2R s1660 sa22 rs12
feature: T440 CCK2R s1660 sa22 rs8
feature: Y438 CCK2R s1660 sa22 rs5
feature: T439 CCK2R s1660 sa22 rs6
feature: I441 CCK2R s1660 sa22 rs9
feature: Y390 CCK2R s1660 sa22 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Pro_caspase_3-RIGHT__Caspase_3-_re557
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re557 934
participant stoichiometry: PARTICIPANT STOICHIOMETRY re557 933
left: Pro-caspase-3
interaction type: STATE_TRANSITION
right: Caspase-3

STATE_TRANSITION_LEFT__MAPK7-RIGHT__MAPK7-_re170
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re170 877
participant stoichiometry: PARTICIPANT STOICHIOMETRY re170 876
left: MAPK7
interaction type: STATE_TRANSITION
right: MAPK7

T439 CCK2R s1410 sa568 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T439
feature location: T439 CCK2R s1410 sa568 rs6 T439
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.751588888718252
comment: MODIFICATION_RESIDUE_NAME=T439

ATF2
type: Protein
entity reference: ATF2 PROTEIN
feature: T71 ATF2 s1835 sa330 rs2
feature: ACTIVE 13
feature: T69 ATF2 s1835 sa330 rs1

Y317 p66 SHC1 s713 sa102 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y317
feature location: Y317 p66 SHC1 s713 sa102 rs1 Y317
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y317
comment: MODIFICATION_RESIDUE_ANGLE=0.756380989872912

CaM s2012 sa1009 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CaM
stoichiometric coefficient: 1.0

uniprot Q8NHX9 52
type: UnificationXref
id: Q8NHX9
db: uniprot

Protein tyrosine sulfotransferase
type: ProteinReference
xref: P07148
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Protein tyrosine_br_sulfotransferase
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein-tyrosine sulfotransferase 1

S338 RAF1 s154 sa685 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S338
feature location: S338 RAF1 s154 sa685 rs1 S338
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S338
comment: MODIFICATION_RESIDUE_ANGLE=1.5707963267948966

PKA-Calpha/beta/gamma
type: ProteinReference
xref: P07099
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PKA-C_alpha_/_beta_/_gamma_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma

STATE_TRANSITION_LEFT__MAPK7-RIGHT__MAPK7-_re163
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re163 924
participant stoichiometry: PARTICIPANT STOICHIOMETRY re163 925
left: MAPK7
interaction type: STATE_TRANSITION
right: MAPK7

S2481 mTOR s924 sa308 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S2481
feature location: S2481 mTOR s924 sa308 rs2 S2481
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8251814037002603
comment: MODIFICATION_RESIDUE_NAME=S2481

FAK1
type: Protein
entity reference: FAK1
feature: Y397 FAK1 s1450 sa782 rs1
feature: Y407 FAK1 s1450 sa782 rs2
feature: Y861 FAK1 s1450 sa782 rs5
feature: ACTIVE 13
feature: Y925 FAK1 s1450 sa782 rs6
feature: COMPLEX PARTICIPANT BINDING FEATURE s1450 sa782 400
feature: Y576 FAK1 s1450 sa782 rs3
feature: Y577 FAK1 s1450 sa782 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

p38MAPK
type: ProteinReference
xref: P07079
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p38MAPK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mitogen-activated protein kinase 14

I441 CCK2R s1235 sa558 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY I441
feature location: I441 CCK2R s1235 sa558 rs9 I441
comment: MODIFICATION_RESIDUE_ANGLE=5.567911979799767
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=I441

S218 MAP2K2 s988 sa206 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S218
feature location: S218 MAP2K2 s988 sa206 rs2 S218
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.536813139478905
comment: MODIFICATION_RESIDUE_NAME=S218

HuR
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.HuR
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re432 1182
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__AKT1_PIP3-RIGHT__AKT1_PIP3-_re110
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re110 1104
participant stoichiometry: PARTICIPANT STOICHIOMETRY re110 1103
left: AKT1-PIP3
interaction type: STATE_TRANSITION
right: AKT1-PIP3

PARTICIPANT STOICHIOMETRY re432 1183
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__AKT1_PIP3-RIGHT__AKT1_PIP3-_re111
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re111 1102
participant stoichiometry: PARTICIPANT STOICHIOMETRY re111 1101
left: AKT1-PIP3
interaction type: STATE_TRANSITION
right: AKT1-PIP3

HETERODIMER_ASSOCIATION_LEFT__ATF2-_JUN-RIGHT__JUN_PLUS_ATF2_-_re451
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re451 1154
participant stoichiometry: PARTICIPANT STOICHIOMETRY re451 1156
participant stoichiometry: PARTICIPANT STOICHIOMETRY re451 1155
left: ATF2
left: JUN
interaction type: HETERODIMER_ASSOCIATION
right: JUN+ATF2

Atypical PKC
type: Protein
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

T359 RSK1 2 s538 sa212 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T359
feature location: T359 RSK1 2 s538 sa212 rs2 T359
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=T359
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7908334448050431

PTHR48019:SF40
type: RelationshipXref
id: PTHR48019:SF40
db: PANTHER Family
relationship type: By Homology

Y460 CAS s764 sa117 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y460
feature location: Y460 CAS s764 sa117 rs4 Y460
comment: MODIFICATION_RESIDUE_NAME=Y460
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.426319326209974

PARTICIPANT STOICHIOMETRY re71 663
type: Stoichiometry
physical entity: CAS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re71 664
type: Stoichiometry
physical entity: CAS
stoichiometric coefficient: 1.0

G34
type: ProteinReference
xref: P07190
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.G34
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Gastrin

TRANSLATION
type: RelationshipTypeVocabulary

Y527 p60 SRC s880 sa97 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 p60 SRC s880 sa97 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y527
comment: MODIFICATION_RESIDUE_ANGLE=5.537766360638166

TRANSPORT_LEFT__CALCA-RIGHT__CALCA-_re504
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re504 1110
participant stoichiometry: PARTICIPANT STOICHIOMETRY re504 1109
left: CALCA s1845 sa796
interaction type: TRANSPORT
right: CALCA

Y77 CCK s1750 sa789 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 CCK s1750 sa789 rs1 Y77
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3832305715485393
comment: MODIFICATION_RESIDUE_NAME=Y77

Stromelysin-1
type: ProteinReference
xref: PTHR10201:SF215
xref: uniprot P08254 48
organism: Homo sapiens

T559 MAP3K14 s864 sa61 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T559
feature location: T559 MAP3K14 s864 sa61 rs1 T559
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T559
comment: MODIFICATION_RESIDUE_ANGLE=0.8027231228841566

Y527 SRC @Galphaq s1605 sa879 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 SRC @Galphaq s1605 sa879 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.585857905576321
comment: MODIFICATION_RESIDUE_NAME=Y527

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re411
controller: CNKSR1

S257 MAP2K4 s996 sa220 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S257
feature location: S257 MAP2K4 s996 sa220 rs1 S257
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S257
comment: MODIFICATION_RESIDUE_ANGLE=0.73

HETERODIMER_ASSOCIATION_LEFT__MAPK1-_MAPK3-RIGHT__MAPK1_3-_re415
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re415 1204
participant stoichiometry: PARTICIPANT STOICHIOMETRY re415 1203
participant stoichiometry: PARTICIPANT STOICHIOMETRY re415 1205
left: MAPK3
left: MAPK1
interaction type: HETERODIMER_ASSOCIATION
right: MAPK1/3

PARTICIPANT STOICHIOMETRY re613 832
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__HBEGF-RIGHT__HBEGF-_re241
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re241 717
participant stoichiometry: PARTICIPANT STOICHIOMETRY re241 718
left: HBEGF
interaction type: TRANSPORT
right: HBEGF

PARTICIPANT STOICHIOMETRY re613 833
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

T71 ATF2 s990 sa754 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T71
feature location: T71 ATF2 s990 sa754 rs2 T71
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5248232251383325
comment: MODIFICATION_RESIDUE_NAME=T71

HETERODIMER_ASSOCIATION_LEFT__CAS-_CRK-RIGHT__CAS_CRK_complex-_re72
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re72 662
participant stoichiometry: PARTICIPANT STOICHIOMETRY re72 661
participant stoichiometry: PARTICIPANT STOICHIOMETRY re72 660
left: CRK
left: CAS
interaction type: HETERODIMER_ASSOCIATION
right: CAS-CRK complex

S221 RSK1 2 s536 sa209 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 RSK1 2 s536 sa209 rs5 S221
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=3.8909266156067464
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221

uniprot Q05655 79
type: UnificationXref
id: Q05655
db: uniprot

BAX
type: Protein
entity reference: BAX

CATALYSIS
type: Catalysis
controller: PI3,4,5-P3

PARTICIPANT STOICHIOMETRY re302 633
type: Stoichiometry
physical entity: Pre-pro CCK @ ER
stoichiometric coefficient: 1.0

PKCepsilon
type: Protein
entity reference: PKCepsilon
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y402 FAK2 s1591 sa878 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y402
feature location: Y402 FAK2 s1591 sa878 rs1 Y402
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.37
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y402

SOS1 s910 sa278 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS1
stoichiometric coefficient: 1.0

S42 FOS s202 sa233 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S42
feature location: S42 FOS s202 sa233 rs3 S42
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S42
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

PARTICIPANT STOICHIOMETRY re494 1022
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re494 1021
type: Stoichiometry
physical entity: CCK-G
stoichiometric coefficient: 1.0

PKCzeta
type: Protein
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

p190RhoGEF s1453 sa785 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p190RhoGEF
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Conventional_PKC-RIGHT__Conventional_PKC-_re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 891
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 890
left: Conventional PKC
interaction type: STATE_TRANSITION
right: Conventional PKC

T423 PAK1 s785 sa139 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T423
feature location: T423 PAK1 s785 sa139 rs1 T423
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.719181924797195
comment: MODIFICATION_RESIDUE_NAME=T423

PTHR10970:SF1
type: RelationshipXref
id: PTHR10970:SF1
db: PANTHER Family
relationship type: By Homology

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__PKCtheta-RIGHT__PKCtheta-_re381
control type: INHIBITION
controller: PKCalpha

MMP7
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.MMP7
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re18 894
type: Stoichiometry
physical entity: Novel PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 895
type: Stoichiometry
physical entity: PKCeta
stoichiometric coefficient: 1.0

S430 CCK1R s1483 sa454 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S430
feature location: S430 CCK1R s1483 sa454 rs4 S430
comment: MODIFICATION_RESIDUE_ANGLE=5.556558434920722
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S430

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__PAI2-RIGHT__PAI2-_re225
controller: CREB1

PARTICIPANT STOICHIOMETRY re302 634
type: Stoichiometry
physical entity: Pro CCK @ TGN
stoichiometric coefficient: 1.0

uniprot O95863 60
type: UnificationXref
id: O95863
db: uniprot

PARTICIPANT STOICHIOMETRY re584 803
type: Stoichiometry
physical entity: SHP-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re584 804
type: Stoichiometry
physical entity: AKT1-PIP3
stoichiometric coefficient: 1.0

T69 ATF2 s1051 sa350 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T69
feature location: T69 ATF2 s1051 sa350 rs1 T69
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T69

CRK
type: Protein
entity reference: CRK
feature: COMPLEX PARTICIPANT BINDING FEATURE s1893 sa977 392
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Adhesion
controller: ITGAV

T202 MAPK1 s831 sa201 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T202
feature location: T202 MAPK1 s831 sa201 rs1 T202
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T202
comment: MODIFICATION_RESIDUE_ANGLE=0.76

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__FOS-RIGHT__FOS-_re206
controller: RHOA-GTP

S63 JUN s1041 sa340 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S63
feature location: S63 JUN s1041 sa340 rs1 S63
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8251814037002603
comment: MODIFICATION_RESIDUE_NAME=S63

PKCeta
type: ProteinReference
xref: P07068
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PKC_eta_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein kinase C eta type

TCF7L2
type: Protein
entity reference: TCF7L2
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

TRUNCATION
type: RelationshipTypeVocabulary

PTHR45807:SF1
type: RelationshipXref
id: PTHR45807:SF1
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__SOS1-_GRB2-RIGHT__Complex__GRB2_SOS1_-_re64
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 692
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 693
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 694
left: SOS1
left: GRB2
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GRB2/SOS1)

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Adhesion
controller: ITGB1

NFKB1 p50 s1883 sa973 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=0.78837880158871
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Cytochrome_C-RIGHT__Cytochrome_C-_re633
controller: BAD/BCL2 heterodimer

PARTICIPANT STOICHIOMETRY re54 722
type: Stoichiometry
physical entity: p60 SRC
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKCdelta-RIGHT__PKCdelta-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 487
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 486
left: PKCdelta
interaction type: STATE_TRANSITION
right: PKCdelta

HETERODIMER_ASSOCIATION_LEFT__14_3_3_beta_alpha-_RAF1-RIGHT__c_RAF_14_3_3_complex-_re518
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re518 1076
participant stoichiometry: PARTICIPANT STOICHIOMETRY re518 1077
participant stoichiometry: PARTICIPANT STOICHIOMETRY re518 1075
left: RAF1
left: 14-3-3 beta/alpha
interaction type: HETERODIMER_ASSOCIATION
right: c-RAF/14-3-3 complex

PARTICIPANT STOICHIOMETRY re54 721
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GAS_REBP3-RIGHT__GAS_REBP3-_re598
controller: AP1 (FOS+JUN)

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SNAI1-RIGHT__SNAI1-_re130
controller: PAK1

HuR
type: Protein
entity reference: HuR
feature: S158 HuR s1073 sa731 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1073 sa731 406
feature: S221 HuR s1073 sa731 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Chromogranin-A
type: DnaReference
xref: PTHR10583:SF1
organism: Homo sapiens

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Protein synthesis
controller: EIF4E

PARTICIPANT STOICHIOMETRY re161 929
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re547 960
type: Stoichiometry
physical entity: PKA Holoenzyme I
stoichiometric coefficient: 1.0

TNF receptor-associated factor 6
type: ProteinReference
xref: PTHR10131:SF131
xref: uniprot Q9Y4K3 20
organism: Homo sapiens

ITGB1
type: ProteinReference
xref: P07113
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.ITGB1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Integrin beta-1

PARTICIPANT STOICHIOMETRY re547 959
type: Stoichiometry
physical entity: cAMP s1840 sa472
stoichiometric coefficient: 1.0

JUN
type: RnaRegion
entity reference: JUN
cellular location: CELL
comment: SPECIES_TYPE=RNA

COX2
type: RnaRegion
entity reference: COX2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1078 sa729 188
cellular location: CELL
comment: SPECIES_TYPE=RNA

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P40763 146
organism: Homo sapiens

S70 FOS s1858 sa234 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S70
feature location: S70 FOS s1858 sa234 rs4 S70
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S70
comment: MODIFICATION_RESIDUE_ANGLE=5.5330859376426975

p52 SHC1
type: Protein
entity reference: p52 SHC1
feature: ACTIVE 13
feature: Y239 240 p52 SHC1 s899 sa274 rs2
feature: Y317 p52 SHC1 s899 sa274 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s899 sa274 268
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Adenylate cyclase
type: ProteinReference
xref: P07127
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Adenylate_br_cyclase
member entity reference: Adenylate cyclase type 1

HDC
type: DnaRegionReference
member entity reference: Histidine decarboxylase
xref: G07262
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.HDC
comment: ENTITY_REFERENCE_NOTES=

UNKNOWN_TRANSITION
type: InteractionVocabulary

p54 SRC
type: Protein
entity reference: p54 SRC
feature: ACTIVE 13
feature: Y527 p54 SRC s879 sa96 rs2
feature: Y416 p54 SRC s879 sa96 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S133 FOS s1858 sa234 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S133
feature location: S133 FOS s1858 sa234 rs5 S133
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S133
comment: MODIFICATION_RESIDUE_ANGLE=0.76

S183 PRAS40 s647 sa173 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S183
feature location: S183 PRAS40 s647 sa173 rs1 S183
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S183
comment: MODIFICATION_RESIDUE_ANGLE=0.7431411193556561

Ribosomal protein S6 kinase beta-1
type: ProteinReference
xref: uniprot P23443 124
xref: PTHR24351:SF48
organism: Homo sapiens

uniprot P08254 48
type: UnificationXref
id: P08254
db: uniprot

PTHR24083:SF48
type: RelationshipXref
id: PTHR24083:SF48
db: PANTHER Family
relationship type: By Homology

GAS-REBP2
type: Protein
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re161 928
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re547 961
type: Stoichiometry
physical entity: PKA-Calpha/beta/gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re547 962
type: Stoichiometry
physical entity: PKA-R1
stoichiometric coefficient: 1.0

mTOR s644 sa311 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mTOR
stoichiometric coefficient: 1.0

S380 RSK1 2 s537 sa211 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S380
feature location: S380 RSK1 2 s537 sa211 rs4 S380
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=1.8133457596088143
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S380

HETERODIMER_ASSOCIATION_LEFT__FOS-_JUN-RIGHT__AP1__FOS_PLUS_JUN_-_re450
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re450 1157
participant stoichiometry: PARTICIPANT STOICHIOMETRY re450 1158
participant stoichiometry: PARTICIPANT STOICHIOMETRY re450 1159
left: JUN
left: FOS
interaction type: HETERODIMER_ASSOCIATION
right: AP1 (FOS+JUN)

S133 CREB1 s187 sa331 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S133
feature location: S133 CREB1 s187 sa331 rs1 S133
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S133
comment: MODIFICATION_RESIDUE_ANGLE=0.693598378065279

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__FOS-RIGHT__FOS-_re206
controller: CREB1

Zinc finger protein SNAI1
type: ProteinReference
xref: PTHR24390:SF92
xref: uniprot O95863 60
organism: Homo sapiens

IL8
type: RnaRegion
entity reference: IL8
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

MYC
type: DnaRegionReference
member entity reference: Myc proto-oncogene protein
xref: G07272
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.MYC
comment: ENTITY_REFERENCE_NOTES=

Gbeta/gamma
type: Protein
entity reference: Gbeta/gamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s737 sa494 398
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MMP3-RIGHT__MMP3-_re51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re51 727
participant stoichiometry: PARTICIPANT STOICHIOMETRY re51 728
left: MMP3
interaction type: STATE_TRANSITION
right: MMP3

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__active_CCK2R_beta_arrestin_complex-RIGHT__active_CCK2R_Beta_arrestin_complex-_re332
controller: AP2M1

S136 BAD s1612 sa892 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S136
feature location: S136 BAD s1612 sa892 rs2 S136
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8079058030724882
comment: MODIFICATION_RESIDUE_NAME=S136

S33 beta catenin s1315 sa638 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S33
feature location: S33 beta catenin s1315 sa638 rs2 S33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7304919088134321
comment: MODIFICATION_RESIDUE_NAME=S33

p46 SHC1 s947 sa279 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p46 SHC1
stoichiometric coefficient: 1.0

SRC @Galphaq s1605 sa879 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKCtheta-RIGHT__PKCtheta-_re381
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re381 1196
participant stoichiometry: PARTICIPANT STOICHIOMETRY re381 1195
left: PKCtheta
interaction type: STATE_TRANSITION
right: PKCtheta

PARTICIPANT STOICHIOMETRY re79 639
type: Stoichiometry
physical entity: CDC42-GTP
stoichiometric coefficient: 1.0

uniprot P35222 101
type: UnificationXref
id: P35222
db: uniprot

PKA R1alpha beta s1531 sa837 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKA-R1alpha/beta
stoichiometric coefficient: 1.0

CCK-8
type: Protein
entity reference: CCK-8
feature: ACTIVE 13
comment: SPECIES_TYPE=PROTEIN

ELK1
type: ProteinReference
xref: P07146
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.ELK1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: ETS domain-containing protein Elk-1

S383 ELK1 s198 sa334 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S383
feature location: S383 ELK1 s198 sa334 rs1 S383
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S383
comment: MODIFICATION_RESIDUE_ANGLE=0.7039197825007742

Y861 FAK1 s776 sa285 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y861
feature location: Y861 FAK1 s776 sa285 rs5 Y861
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.75
comment: MODIFICATION_RESIDUE_NAME=Y861

HRAS-GDP
type: Complex
component stoichiometry: GDP s1803 sa74 STOICHIOMETRY ID COMPLEX
component stoichiometry: HRAS s1804 sa67 STOICHIOMETRY ID COMPLEX
component: GDP
component: HRAS
feature: COMPLEX BINDING FEATURE s1802 csa79 455
feature: COMPLEX BINDING FEATURE s1802 csa79 457
cellular location: CELL

IKBalpha s1210 sa255 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IKBalpha
stoichiometric coefficient: 1.0

MMP7
type: DnaRegion
entity reference: MMP7
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

HRAS-GTP
type: Complex
component stoichiometry: GTP s1806 sa72 STOICHIOMETRY ID COMPLEX
component stoichiometry: HRAS s1805 sa73 STOICHIOMETRY ID COMPLEX
component: GTP
component: HRAS
feature: COMPLEX BINDING FEATURE s1807 csa78 383
feature: COMPLEX BINDING FEATURE s1807 csa78 385
cellular location: CELL

HETERODIMER_ASSOCIATION_LEFT__PDPK1-_PI3,4,5_P3-RIGHT__PDK1_PIP3-_re108
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re108 1123
participant stoichiometry: PARTICIPANT STOICHIOMETRY re108 1122
participant stoichiometry: PARTICIPANT STOICHIOMETRY re108 1124
left: PI3,4,5-P3
left: PDPK1
interaction type: HETERODIMER_ASSOCIATION
right: PDK1-PIP3

STATE_TRANSITION_LEFT__HuR-RIGHT__HuR-_re441
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re441 1173
participant stoichiometry: PARTICIPANT STOICHIOMETRY re441 1172
left: HuR
interaction type: STATE_TRANSITION
right: HuR

Progastrin @ER - Golgi
type: Protein
comment: SPECIES_TYPE=PROTEIN

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__E_cadherin-RIGHT__E_cadherin-_re372
control type: INHIBITION
controller: SNAI1

Y576 FAK1 s1450 sa782 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y576
feature location: Y576 FAK1 s1450 sa782 rs3 Y576
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=1.55
comment: MODIFICATION_RESIDUE_NAME=Y576

TRANSCRIPTION_LEFT__CLU-RIGHT__CLU-_re569
type: TemplateReaction
product: CLU
xref: TRANSCRIPTION
participant: CLU
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Y77 Signal pre pro CCK s1187 sa495 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 Signal pre pro CCK s1187 sa495 rs1 Y77
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4137706713436615
comment: MODIFICATION_RESIDUE_NAME=Y77

PARTICIPANT STOICHIOMETRY re354 530
type: Stoichiometry
physical entity: L-Arg
stoichiometric coefficient: 1.0

PTHR22948:SF57
type: RelationshipXref
id: PTHR22948:SF57
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re354 531
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re354 532
type: Stoichiometry
physical entity: L-Citrulline
stoichiometric coefficient: 1.0

HuR s1073 sa731 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HuR
stoichiometric coefficient: 1.0

PTHR10352:SF13
type: RelationshipXref
id: PTHR10352:SF13
db: PANTHER Family
relationship type: By Homology

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__beta_catenin-RIGHT__beta_catenin-_re374
control type: ACTIVATION
controller: PAK1

STATE_TRANSITION_LEFT__GSK3beta-RIGHT__GSK3beta-_re369
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re369 505
participant stoichiometry: PARTICIPANT STOICHIOMETRY re369 506
left: GSK3beta
interaction type: STATE_TRANSITION
right: GSK3beta

CAS
type: ProteinReference
xref: P07180
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CAS
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Breast cancer anti-estrogen resistance protein 1

STATE_TRANSITION_LEFT__p52_SHC1-RIGHT__p52_SHC1-_re59
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re59 708
participant stoichiometry: PARTICIPANT STOICHIOMETRY re59 707
left: p52 SHC1
interaction type: STATE_TRANSITION
right: p52 SHC1 s721 sa101

IRS1
type: Protein
entity reference: IRS1
feature: COMPLEX PARTICIPANT BINDING FEATURE s911 sa282 250
feature: Y IRS1 s911 sa282 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Signal_pre_pro_CCK-RIGHT__Pre_pro_CCK_@_ER-_re301
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re301 635
participant stoichiometry: PARTICIPANT STOICHIOMETRY re301 636
left: Signal-pre-pro CCK
interaction type: STATE_TRANSITION
right: Pre-pro CCK @ ER

S437 CCK2R s1410 sa568 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S437
feature location: S437 CCK2R s1410 sa568 rs4 S437
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S437
comment: MODIFICATION_RESIDUE_ANGLE=3.6969103423572474
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

TCF7L2
type: ProteinReference
xref: P07126
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.TCF7L2
member entity reference: Transcription factor 4

S73 JUN s191 sa236 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S73
feature location: S73 JUN s191 sa236 rs2 S73
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.53026601520083
comment: MODIFICATION_RESIDUE_NAME=S73

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RHOA_GTP-RIGHT__Pi-_RHOA_GDP-_re75
controller: GAP

PKCeta
type: Protein
entity reference: PKCeta
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

RELA p65 s1682 sa328 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

T277 MAP3K11 s994 sa218 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T277
feature location: T277 MAP3K11 s994 sa218 rs1 T277
comment: MODIFICATION_RESIDUE_ANGLE=0.79
comment: MODIFICATION_RESIDUE_NAME=T277
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

40S ribosomal protein S6
type: ProteinReference
xref: PTHR11502:SF16
xref: uniprot P62753 41
organism: Homo sapiens

S744 PRKD1 s662 sa41 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S744
feature location: S744 PRKD1 s662 sa41 rs1 S744
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7813427511940191
comment: MODIFICATION_RESIDUE_NAME=S744

CCK-22
type: ProteinReference
xref: P07022
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CCK-22
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

S SOS1 s910 sa278 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S SOS1 s910 sa278 rs2 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.511144255404544

Breast cancer anti-estrogen resistance protein 1
type: ProteinReference
xref: uniprot P56945 44
xref: PTHR10654:SF15
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re410
control type: ACTIVATION
controller: 14-3-3 beta/alpha

S380 RSK1 2 s546 sa329 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S380
feature location: S380 RSK1 2 s546 sa329 rs4 S380
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=1.8133457596088143
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S380

PARTICIPANT STOICHIOMETRY re525 1044
type: Stoichiometry
physical entity: SHC3 s710 sa105
stoichiometric coefficient: 1.0

Gbeta gamma s737 sa494 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta/gamma
stoichiometric coefficient: 1.0

sa342_degraded
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=DEGRADED

PARTICIPANT STOICHIOMETRY re525 1043
type: Stoichiometry
physical entity: SHC
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__FAK1_SRC_complex-RIGHT__FAK1_SRC_p190GEF_complex-_re485
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re485 1056
participant stoichiometry: PARTICIPANT STOICHIOMETRY re485 1055
left: FAK1-SRC complex
interaction type: STATE_TRANSITION
right: FAK1-SRC-p190GEF complex

FAK1 s1450 sa782 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re112 1100
type: Stoichiometry
physical entity: mTORC1 complex
stoichiometric coefficient: 1.0

IKBalpha
type: ProteinReference
xref: P07053
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.IKB_alpha_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: NF-kappa-B inhibitor alpha

Tyrosine-protein kinase JAK2
type: ProteinReference
xref: PTHR45807:SF1
xref: uniprot O60674 18
organism: Homo sapiens

RAF1
type: Protein
entity reference: RAF1
feature: S621 RAF1 s154 sa685 rs9
feature: S259 RAF1 s154 sa685 rs3
feature: S43 RAF1 s154 sa685 rs6
feature: S338 RAF1 s154 sa685 rs1
feature: T268 9 RAF1 s154 sa685 rs7
feature: Y341 RAF1 s154 sa685 rs2
feature: S497 9 RAF1 s154 sa685 rs8
feature: S494 RAF1 s154 sa685 rs5
feature: T491 RAF1 s154 sa685 rs4
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

T334 MAPKAP K2 s1584 sa871 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T334
feature location: T334 MAPKAP K2 s1584 sa871 rs3 T334
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T334
comment: MODIFICATION_RESIDUE_ANGLE=0.7737547943982948

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p52_SHC1-RIGHT__p52_SHC1-_re59
controller: SRC @Galphaq

S84 PPARgamma s1445 sa778 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S84
feature location: S84 PPARgamma s1445 sa778 rs1 S84
comment: MODIFICATION_RESIDUE_ANGLE=0.7540866087105068
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S84

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ELK1-RIGHT__ELK1-_re623
controller: PP2B

uniprot P15884 164
type: UnificationXref
id: P15884
db: uniprot

JUN
type: Protein
entity reference: JUN
feature: S63 JUN s1859 sa235 rs1
feature: ACTIVE 13
feature: S73 JUN s1859 sa235 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

IRS1
type: Protein
entity reference: IRS1
feature: Y IRS1 s1667 sa819 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CSK
type: ProteinReference
xref: P07072
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CSK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Tyrosine-protein kinase CSK

MAP2K4
type: ProteinReference
xref: P07074
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAP2K4
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4

PARTICIPANT STOICHIOMETRY re543 966
type: Stoichiometry
physical entity: PLA2 s1516 sa827
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re543 965
type: Stoichiometry
physical entity: PLA2
stoichiometric coefficient: 1.0

S338 RAF1 s155 sa679 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S338
feature location: S338 RAF1 s155 sa679 rs1 S338
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S338
comment: MODIFICATION_RESIDUE_ANGLE=1.5707963267948966

Y416 p54 SRC s879 sa96 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 p54 SRC s879 sa96 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7676104001149276

s1787
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=DEGRADED

Y992 EGFR s727 sa266 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y992
feature location: Y992 EGFR s727 sa266 rs6 Y992
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.566859320696339
comment: MODIFICATION_RESIDUE_NAME=Y992

Cell growth and proliferation
type: Pathway

S43 RAF1 s1721 sa694 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S43
feature location: S43 RAF1 s1721 sa694 rs6 S43
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.908388522052502
comment: MODIFICATION_RESIDUE_NAME=S43

PARTICIPANT STOICHIOMETRY re303 632
type: Stoichiometry
physical entity: Pro-CCK @ secretory granule
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re303 631
type: Stoichiometry
physical entity: Pro CCK @ TGN
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__FOS-RIGHT__FOS-_re621
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re621 791
participant stoichiometry: PARTICIPANT STOICHIOMETRY re621 792
left: FOS
interaction type: STATE_TRANSITION
right: FOS

PRKD2
type: Protein
entity reference: PRKD2
feature: ACTIVE 13
feature: S876 PRKD2 s1388 sa736 rs1
feature: S710 PRKD2 s1388 sa736 rs3
feature: S706 PRKD2 s1388 sa736 rs2
feature: S244 PRKD2 s1388 sa736 rs6
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

S374 FOS s1040 sa339 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S374
feature location: S374 FOS s1040 sa339 rs6 S374
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=1.5878173396239432
comment: MODIFICATION_RESIDUE_NAME=S374

…
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

PKA-Calpha/beta/gamma
type: Protein
entity reference: PKA-Calpha/beta/gamma
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

Y891 EGFR s727 sa266 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y891
feature location: Y891 EGFR s727 sa266 rs4 Y891
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.6458466468384008
comment: MODIFICATION_RESIDUE_NAME=Y891

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HRAS_GDP-RIGHT__HRAS_GTP-_re523
controller: SHC1-GRB2-SOS1

TFF1
type: RnaRegion
entity reference: TFF1
cellular location: CELL
comment: SPECIES_TYPE=RNA

Migration
type: Pathway

G17 - Gly
type: Protein
entity reference: G17 - Gly
feature: Y G17 Gly s10 sa84 rs1
comment: SPECIES_TYPE=PROTEIN

Casein kinase I isoform alpha
type: ProteinReference
xref: PTHR11909:SF84
xref: uniprot P48729 150
organism: Homo sapiens

PTHR11909:SF18
type: RelationshipXref
id: PTHR11909:SF18
db: PANTHER Family
relationship type: By Homology

14-3-3 beta/alpha
type: Protein
entity reference: 14-3-3 beta/alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s1334 sa690 296
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

cAMP s1532 sa838 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SHC1-RIGHT__SHC1_@EGFR-_re63
controller: Complex (HBEGF/EGFR)

PTHR24085:SF1
type: RelationshipXref
id: PTHR24085:SF1
db: PANTHER Family
relationship type: By Homology

Induced myeloid leukemia cell differentiation protein Mcl-1
type: DnaReference
xref: PTHR11256:SF46
organism: Homo sapiens

IRS1
type: Protein
entity reference: IRS1
feature: Y IRS1 s933 sa295 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s933 sa295 432
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot P48730 75
organism: Homo sapiens

G34-Gly
type: Protein
entity reference: G34-Gly
feature: Y G34 Gly s7 sa80 rs1
comment: SPECIES_TYPE=PROTEIN

MEF2C
type: ProteinReference
xref: P07222
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MEF2C
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Myocyte-specific enhancer factor 2C

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__BAX-_BCL2-RIGHT__BAX_BCL2_heterodimer-_re560
controller: PAK1

Integrin alpha-V
type: DnaReference
xref: PTHR23220:SF4
organism: Homo sapiens

Y239 240 p66 SHC1 s728 sa99 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y239 240
feature location: Y239 240 p66 SHC1 s728 sa99 rs2 Y239 240
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3469545117994337
comment: MODIFICATION_RESIDUE_NAME=Y239/240

Endoplasmic Reticulum
type: CellularLocationVocabulary
xref: go GO:0005783 2

Signal-pre-pro CCK
type: Protein
entity reference: Signal-pre-pro CCK
feature: Y91 Signal pre pro CCK s1187 sa495 rs2
feature: Y94 Signal pre pro CCK s1187 sa495 rs3
feature: Y77 Signal pre pro CCK s1187 sa495 rs1
comment: SPECIES_TYPE=PROTEIN

BAD
type: Protein
entity reference: BAD
feature: S136 BAD s1565 sa857 rs2
feature: S112 BAD s1565 sa857 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1565 sa857 242
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

uniprot P05771 43
type: UnificationXref
id: P05771
db: uniprot

ITGAV
type: Protein
entity reference: ITGAV
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Integrin beta-1
type: DnaReference
xref: PTHR10082:SF28
organism: Homo sapiens

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P05412 121
organism: Homo sapiens

TRANSPORT_LEFT__HDC-RIGHT__HDC-_re438
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re438 1176
participant stoichiometry: PARTICIPANT STOICHIOMETRY re438 1177
left: HDC
interaction type: TRANSPORT
right: HDC

TRANSPORT_LEFT__FOS-RIGHT__FOS-_re539
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re539 993
participant stoichiometry: PARTICIPANT STOICHIOMETRY re539 994
left: FOS
interaction type: TRANSPORT
right: FOS

uniprot P60953 61
type: UnificationXref
id: P60953
db: uniprot

Phosphatidylinositol 3-kinase regulatory subunit alpha
type: ProteinReference
xref: PTHR10155:SF3
xref: uniprot P27986 46
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re102 1138
type: Stoichiometry
physical entity: PI3K Class I
stoichiometric coefficient: 1.0

uniprot Q14643 155
type: UnificationXref
id: Q14643
db: uniprot

PARTICIPANT STOICHIOMETRY re102 1137
type: Stoichiometry
physical entity: PI3K Class I
stoichiometric coefficient: 1.0

Y438 CCK2R s1688 sa565 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y438
feature location: Y438 CCK2R s1688 sa565 rs5 Y438
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y438
comment: MODIFICATION_RESIDUE_ANGLE=4.421329661007988
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

T SOS1 s749 sa276 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T SOS1 s749 sa276 rs1 T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_ANGLE=0.8611146530060259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

STATE_TRANSITION_LEFT__GAS_REBP1-RIGHT__GAS_REBP1-_re596
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re596 757
participant stoichiometry: PARTICIPANT STOICHIOMETRY re596 758
left: GAS-REBP1
interaction type: STATE_TRANSITION
right: GAS-REBP1

G17
type: ProteinReference
xref: P07215
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.G17
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Gastrin

S244 PRKD2 s773 sa696 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S244
feature location: S244 PRKD2 s773 sa696 rs6 S244
comment: MODIFICATION_RESIDUE_NAME=S244
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.822805346332478

Gbeta
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1372 sa698 212
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re419 1200
type: Stoichiometry
physical entity: MMP7
stoichiometric coefficient: 1.0

Late endosome
type: CellularLocationVocabulary
xref: go GO:0005770 3

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SRC_@Galphaq-RIGHT__SRC_@Galphaq-_re613
controller: CSK

Y925 FAK1 s776 sa285 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y925
feature location: Y925 FAK1 s776 sa285 rs6 Y925
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.95
comment: MODIFICATION_RESIDUE_NAME=Y925

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

go GO:0005783 2
type: UnificationXref
id: GO:0005783
db: go

ACAT1
type: DnaRegionReference
member entity reference: Acetyl-CoA acetyltransferase, mitochondrial
xref: G07285
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.ACAT1

p60 SRC
type: ProteinReference
xref: P07207
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p60 SRC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Proto-oncogene tyrosine-protein kinase Src

uniprot P19419 84
type: UnificationXref
id: P19419
db: uniprot

PTHR10337:SF2
type: RelationshipXref
id: PTHR10337:SF2
db: PANTHER Family
relationship type: By Homology

Prostaglandin G/H synthase 2
type: DnaReference
organism: Homo sapiens

Y705 STAT3 s675 sa180 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y705
feature location: Y705 STAT3 s675 sa180 rs1 Y705
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.71
comment: MODIFICATION_RESIDUE_NAME=Y705

STATE_TRANSITION_LEFT__FAK2_SRC_complex-RIGHT__FAK2_SRC_complex-_re311
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re311 597
participant stoichiometry: PARTICIPANT STOICHIOMETRY re311 598
left: FAK2-SRC complex
interaction type: STATE_TRANSITION
right: FAK2-SRC complex

Endosome
type: CellularLocationVocabulary
xref: go GO:0005768 6

TRANSCRIPTION_LEFT__HuR-RIGHT__HuR-_re428
type: TemplateReaction
product: HuR
xref: TRANSCRIPTION
participant: HuR
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

MAP3K14
type: Protein
entity reference: MAP3K14
feature: ACTIVE 13
feature: T559 MAP3K14 s864 sa61 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

BAD
type: Protein
entity reference: BAD
feature: S136 BAD s1561 sa290 rs2
feature: S112 BAD s1561 sa290 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1561 sa290 236
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

Y G17 s17 sa89 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y G17 s17 sa89 rs1 Y
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.7742892784837644

go GO:0005770 3
type: UnificationXref
id: GO:0005770
db: go

PARTICIPANT STOICHIOMETRY re536 999
type: Stoichiometry
physical entity: RSK1/2
stoichiometric coefficient: 1.0

Lysosome
type: CellularLocationVocabulary
xref: go GO:0005764 5

S43 RAF1 s154 sa685 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S43
feature location: S43 RAF1 s154 sa685 rs6 S43
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.908388522052502
comment: MODIFICATION_RESIDUE_NAME=S43

S45 beta catenin s1274 sa636 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S45
feature location: S45 beta catenin s1274 sa636 rs3 S45
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S45
comment: MODIFICATION_RESIDUE_ANGLE=3.845512436090568

Y418 SRC @Galphaq s1769 sa881 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y418
feature location: Y418 SRC @Galphaq s1769 sa881 rs3 Y418
comment: MODIFICATION_RESIDUE_NAME=Y418
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3192345766207003

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SNAI1-RIGHT__SNAI1-_re129
controller: GSK3beta

MAPK8-10
type: Protein
entity reference: MAPK8-10
feature: ACTIVE 13
feature: T183 MAPK8 10 s665 sa222 rs1
feature: Y185 MAPK8 10 s665 sa222 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TRANSLATION_LEFT__uPA-RIGHT__uPA-_re625
type: TemplateReaction
product: uPA
xref: TRANSLATION
participant: uPA
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

HBEGF
type: RnaRegion
entity reference: HBEGF
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re115 1094
type: Stoichiometry
physical entity: mTORC1 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re115 1093
type: Stoichiometry
physical entity: mTORC1 complex
stoichiometric coefficient: 1.0

IKKgamma s1812 sa258 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IKKgamma
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__IL8-RIGHT__IL8-_re439
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re439 1175
participant stoichiometry: PARTICIPANT STOICHIOMETRY re439 1174
left: IL8
interaction type: TRANSPORT
right: IL8

RPS6 s663 sa170 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.786798160123647

Y238 CCK2R s1688 sa565 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y238
feature location: Y238 CCK2R s1688 sa565 rs7 Y238
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789
comment: MODIFICATION_RESIDUE_NAME=Y238

HuR
type: Protein
entity reference: HuR
feature: ACTIVE 13
feature: S221 HuR s1007 sa727 rs2
feature: S158 HuR s1007 sa727 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re79 640
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re79 641
type: Stoichiometry
physical entity: CDC42-GDP
stoichiometric coefficient: 1.0

MEN1
type: ProteinReference
xref: P07084
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MEN1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: O00255

Beta-arrestin-2
type: ProteinReference
xref: PTHR11792:SF20
xref: uniprot P32121 37
organism: Homo sapiens

PTHR13826:SF17
type: RelationshipXref
id: PTHR13826:SF17
db: PANTHER Family
relationship type: By Homology

Y783 PLCgamma1 s716 sa18 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y783
feature location: Y783 PLCgamma1 s716 sa18 rs3 Y783
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7540866087105068
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y783

PTHR13826:SF18
type: RelationshipXref
id: PTHR13826:SF18
db: PANTHER Family
relationship type: By Homology

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 10

SRC s107 sa677 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8196755025969574
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Y771 PLCgamma1 s1622 sa903 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y771
feature location: Y771 PLCgamma1 s1622 sa903 rs2 Y771
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y771
comment: MODIFICATION_RESIDUE_ANGLE=2.4116017680334347

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAP3K11-RIGHT__MAP3K11-_re149
controller: HRAS-GTP

GTP s1806 sa72 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re406
controller: S/T kinase(s)

PARTICIPANT STOICHIOMETRY re294 563
type: Stoichiometry
physical entity: Adenylate cyclase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re294 562
type: Stoichiometry
physical entity: Adenylate cyclase
stoichiometric coefficient: 1.0

GalphaS
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1182 sa490 300
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Novel_PKC-RIGHT__Novel_PKC-_re21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 869
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 868
left: Novel PKC
interaction type: STATE_TRANSITION
right: Novel PKC

Mitochondria
type: CellularLocationVocabulary
xref: go GO:0005739 8

S442 CCK2R s1235 sa558 rs10
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S442
feature location: S442 CCK2R s1235 sa558 rs10 S442
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=6.097097937454755
comment: MODIFICATION_RESIDUE_NAME=S442

PTHR24351:SF43
type: RelationshipXref
id: PTHR24351:SF43
db: PANTHER Family
relationship type: By Homology

S36 IKBalpha s852 sa62 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S36
feature location: S36 IKBalpha s852 sa62 rs2 S36
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.54004418782393
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S36

PTHR24072:SF153
type: RelationshipXref
id: PTHR24072:SF153
db: PANTHER Family
relationship type: By Homology

PTHR24351:SF48
type: RelationshipXref
id: PTHR24351:SF48
db: PANTHER Family
relationship type: By Homology

PP2A
type: Protein
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PAI2
type: RnaRegion
entity reference: PAI2
cellular location: CELL
comment: SPECIES_TYPE=RNA

NFKB1 p50 s1883 sa973 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NFKB1 (p50)
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__RYR1_2_3-RIGHT__RYR1_2_3-_re515
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re515 1078
participant stoichiometry: PARTICIPANT STOICHIOMETRY re515 1079
left: RYR1/2/3
interaction type: STATE_TRANSITION
right: RYR1/2/3

TRANSPORT_LEFT__CLU-RIGHT__CLU-_re602
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re602 883
participant stoichiometry: PARTICIPANT STOICHIOMETRY re602 882
left: CLU
interaction type: TRANSPORT
right: CLU

FOXO1
type: Protein
entity reference: FOXO1
feature: S256 FOXO1 s1990 sa994 rs1
feature: T24 FOXO1 s1990 sa994 rs3
feature: S319 FOXO1 s1990 sa994 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S36 IKBalpha s1210 sa255 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S36
feature location: S36 IKBalpha s1210 sa255 rs2 S36
comment: MODIFICATION_RESIDUE_ANGLE=5.54004418782393
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S36

CCK
type: Protein
entity reference: CCK
feature: Y77 CCK s1750 sa789 rs1
feature: Y91 CCK s1750 sa789 rs2
feature: ACTIVE 13
feature: Y94 CCK s1750 sa789 rs3
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re454 1148
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

p46 SHC1
type: Protein
entity reference: p46 SHC1
feature: COMPLEX PARTICIPANT BINDING FEATURE s947 sa279 412
feature: ACTIVE 13
feature: Y239 240 p46 SHC1 s947 sa279 rs2
feature: Y317 p46 SHC1 s947 sa279 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re454 1149
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 2.0

SAP1
type: ProteinReference
xref: P07097
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.SAP1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: ETS domain-containing protein Elk-4

HuR
type: DnaRegionReference
member entity reference: ELAV-like protein 1
xref: G07273
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.HuR
comment: ENTITY_REFERENCE_NOTES=

PTHR24351:SF58
type: RelationshipXref
id: PTHR24351:SF58
db: PANTHER Family
relationship type: By Homology

uniprot P05556 131
type: UnificationXref
id: P05556
db: uniprot

S621 RAF1 s155 sa679 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S621
feature location: S621 RAF1 s155 sa679 rs9 S621
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S621
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.46201537231871

PARTICIPANT STOICHIOMETRY re311 598
type: Stoichiometry
physical entity: FAK2-SRC complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re311 597
type: Stoichiometry
physical entity: FAK2-SRC complex
stoichiometric coefficient: 1.0

TFF1
type: DnaRegion
entity reference: TFF1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Protein-tyrosine kinase 2-beta
type: ProteinReference
xref: PTHR24418:SF94
xref: uniprot Q14289 72
organism: Homo sapiens

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

PTHR11909:SF84
type: RelationshipXref
id: PTHR11909:SF84
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re439 1175
type: Stoichiometry
physical entity: IL8
stoichiometric coefficient: 1.0

PKCdelta
type: Protein
entity reference: PKCdelta
feature: T505 PKCdelta s1339 sa6 rs1
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re439 1174
type: Stoichiometry
physical entity: IL8
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re149 971
type: Stoichiometry
physical entity: MAP3K11
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re149 972
type: Stoichiometry
physical entity: MAP3K11
stoichiometric coefficient: 1.0

PKCtheta
type: Protein
entity reference: PKCtheta
feature: T538 PKCtheta s1796 sa642 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR11849:SF178
type: RelationshipXref
id: PTHR11849:SF178
db: PANTHER Family
relationship type: By Homology

go GO:0005768 6
type: UnificationXref
id: GO:0005768
db: go

LARG
type: Protein
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PLA2
type: Protein
entity reference: PLA2
feature: S727 PLA2 s1515 sa826 rs1
feature: S505 PLA2 s1515 sa826 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot P24723 163
type: UnificationXref
id: P24723
db: uniprot

uniprot P32121 37
type: UnificationXref
id: P32121
db: uniprot

BAD
type: ProteinReference
xref: P07210
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.BAD
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Bcl2-associated agonist of cell death

uniprot P06730 28
type: UnificationXref
id: P06730
db: uniprot

STATE_TRANSITION_LEFT__SHC1-RIGHT__SHC1_@EGFR-_re63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 695
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 696
left: SHC1
interaction type: STATE_TRANSITION
right: SHC1 @EGFR

BAD/BCL2L1 heterodimer
type: Complex
component stoichiometry: BAD s1615 sa893 STOICHIOMETRY ID COMPLEX
component stoichiometry: BCL2L1 s1613 sa895 STOICHIOMETRY ID COMPLEX
component: BAD
component: BCL2L1
feature: COMPLEX BINDING FEATURE s1965 csa75 217
feature: COMPLEX BINDING FEATURE s1965 csa75 219
cellular location: Mitochondria

TPC1/2
type: ProteinReference
xref: P07209
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.TPC1/2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Two pore calcium channel protein 2
member entity reference: Two pore calcium channel protein 1

CCK-33
type: Protein
entity reference: CCK-33
feature: ACTIVE 13
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re2 494
type: Stoichiometry
physical entity: PI4,5 P2 s35 sa19
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 496
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 495
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__c_RAF___RAF1-RIGHT__RAF1-_re530
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re530 1015
participant stoichiometry: PARTICIPANT STOICHIOMETRY re530 1016
left: c-RAF / RAF1
interaction type: KNOWN_TRANSITION_OMITTED
right: RAF1

GRB2 @EGFR
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s893 sa269 342
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TPC1/2
type: Protein
entity reference: TPC1/2
cellular location: Lysosome
comment: SPECIES_TYPE=PROTEIN

T202 MAPK3 s830 sa203 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T202
feature location: T202 MAPK3 s830 sa203 rs1 T202
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.79
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T202

BAX
type: Protein
entity reference: BAX

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Migration
controller: MMP7

S246 SNAI1 s54 sa197 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S246
feature location: S246 SNAI1 s54 sa197 rs1 S246
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S246

p46 SHC1
type: ProteinReference
xref: P07098
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p46 SHC1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: SHC-transforming protein 1

CCK1R
type: Protein
feature: S260 CCK1R s1483 sa454 rs1
feature: S430 CCK1R s1483 sa454 rs4
feature: S307 CCK1R s1483 sa454 rs3
feature: S264 CCK1R s1483 sa454 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1483 sa454 434
cellular location: Endosome
comment: SPECIES_TYPE=PROTEIN

FAK2 s1598 sa886 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK2
stoichiometric coefficient: 1.0

NFKB1 p50 s1747 sa264 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.78837880158871
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Beta-arrestin-1/2
type: Protein
entity reference: Beta-arrestin-1/2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR24349:SF338
type: RelationshipXref
id: PTHR24349:SF338
db: PANTHER Family
relationship type: By Homology

Galpha q s22 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galpha q
stoichiometric coefficient: 1.0

PKA-R2alpha/beta
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1520 sa830 324
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Migration
controller: FAK1-SRC complex

PARTICIPANT STOICHIOMETRY re70 666
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re70 665
type: Stoichiometry
physical entity: Paxillin
stoichiometric coefficient: 1.0

MAP2K5
type: Protein
entity reference: MAP2K5
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3,4,5_P3-RIGHT__PI4,5_P2-_re104
controller: PTEN

PKCzeta
type: Protein
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PKA R2alpha beta s1528 sa834 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKA-R2alpha/beta
stoichiometric coefficient: 1.0

Y418 SRC @Galphaq s1782 sa950 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y418
feature location: Y418 SRC @Galphaq s1782 sa950 rs3 Y418
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y418
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3192345766207003

JUN+ATF2
type: Complex
component stoichiometry: JUN s1050 sa349 STOICHIOMETRY ID COMPLEX
component stoichiometry: ATF2 s1051 sa350 STOICHIOMETRY ID COMPLEX
component: ATF2
component: JUN s1050 sa349
feature: COMPLEX BINDING FEATURE s1993 csa36 345
feature: COMPLEX BINDING FEATURE s1993 csa36 347
cellular location: NUCLEUS

CCK1R (active)
type: Complex
component stoichiometry: CCK s1910 sa946 STOICHIOMETRY ID COMPLEX
component stoichiometry: CCK1R s1485 sa456 STOICHIOMETRY ID COMPLEX
component: CCK
component: CCK1R
feature: COMPLEX BINDING FEATURE s1999 csa40 197
feature: COMPLEX BINDING FEATURE s1999 csa40 199
cellular location: CELL

uniprot Q13464 169
type: UnificationXref
id: Q13464
db: uniprot

Y762 CAS s766 sa287 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y762
feature location: Y762 CAS s766 sa287 rs1 Y762
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.480462184295429
comment: MODIFICATION_RESIDUE_NAME=Y762
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PI4,5-P2
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Y221 MAPK7 s1970 sa988 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y221
feature location: Y221 MAPK7 s1970 sa988 rs2 Y221
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=Y221
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_TYPE=residue

TRAF6
type: Protein
entity reference: TRAF6
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__MMP7-RIGHT__MMP7-_re418
controller: JUN

Y580 SHP 2 s1444 sa629 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y580
feature location: Y580 SHP 2 s1444 sa629 rs1 Y580
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.781719483475212
comment: MODIFICATION_RESIDUE_NAME=Y580

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK7-RIGHT__MAPK7-_re163
controller: MAP2K5

CCK2R
type: Protein
entity reference: CCK2R
feature: S154 CCK2R s1235 sa558 rs3
feature: Y438 CCK2R s1235 sa558 rs5
feature: T443 CCK2R s1235 sa558 rs11
feature: I441 CCK2R s1235 sa558 rs9
feature: S434 CCK2R s1235 sa558 rs12
feature: T439 CCK2R s1235 sa558 rs6
feature: Y390 CCK2R s1235 sa558 rs1
feature: Y238 CCK2R s1235 sa558 rs7
feature: S437 CCK2R s1235 sa558 rs4
feature: T440 CCK2R s1235 sa558 rs8
feature: S82 CCK2R s1235 sa558 rs2
feature: S442 CCK2R s1235 sa558 rs10
cellular location: Late endosome
comment: SPECIES_TYPE=PROTEIN

AP2M1
type: Protein
entity reference: AP2M1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

CLU
type: RnaRegion
entity reference: CLU
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

PKCalpha
type: Protein
entity reference: PKCalpha
feature: ACTIVE 13
feature: S657 PKCalpha s1994 sa25 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CCK2R
type: ProteinReference
xref: P07042
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.RECEPTOR.CCK2R
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Gastrin/cholecystokinin type B receptor

beta catenin s1315 sa638 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

T2446 mTOR s924 sa308 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T2446
feature location: T2446 mTOR s924 sa308 rs4 T2446
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T2446
comment: MODIFICATION_RESIDUE_ANGLE=2.3667132155949893

S9 GSK3beta s935 sa199 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S9
feature location: S9 GSK3beta s935 sa199 rs1 S9
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S9
comment: MODIFICATION_RESIDUE_ANGLE=0.7039197825007742

YES1
type: ProteinReference
xref: P07142
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.YES1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Tyrosine-protein kinase Yes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RSK1_2-RIGHT__RSK1_2-_re144
controller: MAPK1/3

PARTICIPANT STOICHIOMETRY re635 737
type: Stoichiometry
physical entity: BCL2
stoichiometric coefficient: 1.0

uniprot P11597 94
type: UnificationXref
id: P11597
db: uniprot

Plasminogen activator inhibitor 2
type: DnaReference
xref: PTHR11461:SF61
organism: Homo sapiens

Y317 p52 SHC1 s721 sa101 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y317
feature location: Y317 p52 SHC1 s721 sa101 rs1 Y317
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y317
comment: MODIFICATION_RESIDUE_ANGLE=0.8063981142904283

CCK-83
type: ProteinReference
xref: P07118
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CCK-83
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

MAPK8-10
type: ProteinReference
xref: P07090
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAPK8-10
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase 10

Plasminogen activator inhibitor 1
type: DnaReference
xref: PTHR11461:SF49
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re635 738
type: Stoichiometry
physical entity: BCL2
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__TPC1_2-RIGHT__TPC1_2-_re360
control type: ACTIVATION
controller: NAADP

mTOR
type: Protein
feature: S2448 mTOR s644 sa311 rs3
feature: COMPLEX PARTICIPANT BINDING FEATURE s644 sa311 180
feature: S2481 mTOR s644 sa311 rs2
feature: S1261 mTOR s644 sa311 rs1
feature: T2446 mTOR s644 sa311 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re110 1104
type: Stoichiometry
physical entity: AKT1-PIP3
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CAS-RIGHT__CAS-_re71
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re71 663
participant stoichiometry: PARTICIPANT STOICHIOMETRY re71 664
left: CAS
interaction type: STATE_TRANSITION
right: CAS

AKT1
type: Protein
entity reference: AKT1
feature: S473 AKT1 s908 sa303 rs2
feature: T308 AKT1 s908 sa303 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s908 sa303 334
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y881 FAK2 s1604 sa880 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y881
feature location: Y881 FAK2 s1604 sa880 rs4 Y881
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5
comment: MODIFICATION_RESIDUE_NAME=Y881

PARTICIPANT STOICHIOMETRY re156 940
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re156 942
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

TFF2
type: RnaRegion
entity reference: TFF2
cellular location: CELL
comment: SPECIES_TYPE=RNA

MAPK1 3 s1857 sa216 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re156 941
type: Stoichiometry
physical entity: HRAS-GTP
stoichiometric coefficient: 1.0

uniprot P42574 50
type: UnificationXref
id: P42574
db: uniprot

S78 HSP27 s1585 sa872 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S78
feature location: S78 HSP27 s1585 sa872 rs2 S78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S78
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

RSK1/2
type: Protein
entity reference: RSK1/2
feature: T359 RSK1 2 s1856 sa215 rs2
feature: ACTIVE 13
feature: T573 RSK1 2 s1856 sa215 rs3
feature: S221 RSK1 2 s1856 sa215 rs5
feature: S380 RSK1 2 s1856 sa215 rs4
feature: S363 RSK1 2 s1856 sa215 rs1
feature: S749 RSK1 2 s1856 sa215 rs6
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__HBEGF-RIGHT__Pro_HBEGF-_re242
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re242 714
participant stoichiometry: PARTICIPANT STOICHIOMETRY re242 713
left: HBEGF
interaction type: TRANSPORT
right: Pro HBEGF

PARTICIPANT STOICHIOMETRY re156 939
type: Stoichiometry
physical entity: HRAS-GDP
stoichiometric coefficient: 1.0

p52 SHC1 s899 sa274 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p52 SHC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re351 537
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re351 538
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q04759 35
xref: PTHR24356:SF181
organism: Homo sapiens

SNAI1
type: Protein
entity reference: SNAI1
feature: S246 SNAI1 s970 sa189 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

T389 p70S6K1 s649 sa178 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T389
feature location: T389 p70S6K1 s649 sa178 rs1 T389
comment: MODIFICATION_RESIDUE_NAME=T389
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.71

T491 RAF1 s155 sa679 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T491
feature location: T491 RAF1 s155 sa679 rs4 T491
comment: MODIFICATION_RESIDUE_NAME=T491
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.3986264000533355

S32 FOS s1858 sa234 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S32
feature location: S32 FOS s1858 sa234 rs2 S32
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S32
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.845512436090568

PARTICIPANT STOICHIOMETRY re82 605
type: Stoichiometry
physical entity: PAK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re82 604
type: Stoichiometry
physical entity: PAK1
stoichiometric coefficient: 1.0

HSP27
type: ProteinReference
xref: P07154
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.HSP27
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Heat shock protein beta-1

GCG
type: RnaRegion
entity reference: GCG
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK1-RIGHT__MAPK1-_re153
controller: MAP2K1

Atypical PKC
type: Protein
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re110 1103
type: Stoichiometry
physical entity: AKT1-PIP3
stoichiometric coefficient: 1.0

S112 BAD s790 sa150 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S112
feature location: S112 BAD s790 sa150 rs1 S112
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.538835828280262
comment: MODIFICATION_RESIDUE_NAME=S112

beta-catenin
type: Protein
entity reference: beta-catenin
feature: S37 beta catenin s1852 sa183 rs1
feature: S45 beta catenin s1852 sa183 rs3
feature: T41 beta catenin s1852 sa183 rs4
feature: S33 beta catenin s1852 sa183 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__MCL1-RIGHT__MCL1-_re541
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re541 970
participant stoichiometry: PARTICIPANT STOICHIOMETRY re541 969
left: MCL1
interaction type: TRANSPORT
right: MCL1

S133 FOS s202 sa233 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S133
feature location: S133 FOS s202 sa233 rs5 S133
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S133
comment: MODIFICATION_RESIDUE_ANGLE=0.76

GTP s140 sa575 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP s140 sa575
stoichiometric coefficient: 1.0

P07091
type: UnificationXref
id: P07091
db: PANTHER Pathway Component

P07090
type: UnificationXref
id: P07090
db: PANTHER Pathway Component

NOS1
type: ProteinReference
xref: P07158
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.NOS1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Nitric oxide synthase, brain

P07092
type: UnificationXref
id: P07092
db: PANTHER Pathway Component

S307 CCK1R s1483 sa454 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S307
feature location: S307 CCK1R s1483 sa454 rs3 S307
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.912135572113799
comment: MODIFICATION_RESIDUE_NAME=S307

PARTICIPANT STOICHIOMETRY re36 818
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

S727 PLA2 s1871 sa825 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S727
feature location: S727 PLA2 s1871 sa825 rs1 S727
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S727
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.776265626613757

PARTICIPANT STOICHIOMETRY re121 1066
type: Stoichiometry
physical entity: PRAS40
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re36 817
type: Stoichiometry
physical entity: TAK1
stoichiometric coefficient: 1.0

P07098
type: UnificationXref
id: P07098
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re121 1065
type: Stoichiometry
physical entity: PRAS40
stoichiometric coefficient: 1.0

RELA (p65)
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1748 sa265 450
feature: RELA p65 s1748 sa265 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

P07099
type: UnificationXref
id: P07099
db: PANTHER Pathway Component

P07094
type: UnificationXref
id: P07094
db: PANTHER Pathway Component

P07095
type: UnificationXref
id: P07095
db: PANTHER Pathway Component

IKKbeta
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1813 sa262 472
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION_LEFT__PKA_Holoenzyme_II-_cAMP-RIGHT__PKA_Calpha_beta_gamma-_PKA_R2-_re548
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re548 957
participant stoichiometry: PARTICIPANT STOICHIOMETRY re548 958
participant stoichiometry: PARTICIPANT STOICHIOMETRY re548 956
participant stoichiometry: PARTICIPANT STOICHIOMETRY re548 955
left: PKA Holoenzyme II
left: cAMP s1840 sa472
interaction type: DISSOCIATION
right: PKA-Calpha/beta/gamma
right: PKA-R2

Ggamma s1371 sa697 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

P07097
type: UnificationXref
id: P07097
db: PANTHER Pathway Component

Y397 FAK1 s1450 sa782 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y397
feature location: Y397 FAK1 s1450 sa782 rs1 Y397
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.47
comment: MODIFICATION_RESIDUE_NAME=Y397
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

Apoptosis regulator BAX
type: ProteinReference
xref: PTHR11256:SF42
xref: uniprot Q07812 88
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__NFKB1_RELA_IKB_complex-RIGHT__NFKB_RELA_heterodimer-_IKBalpha-_re384
controller: PRKD1

GAS-REBP1
type: Protein
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

Bcl-2-like protein 1
type: ProteinReference
xref: uniprot Q07817 132
xref: PTHR11256:SF12
organism: Homo sapiens

Forkhead box protein O1
type: ProteinReference
xref: PTHR45767:SF1
xref: uniprot Q12778 59
organism: Homo sapiens

RAF1
type: Protein
entity reference: RAF1
feature: T268 9 RAF1 s155 sa679 rs7
feature: S43 RAF1 s155 sa679 rs6
feature: Y341 RAF1 s155 sa679 rs2
feature: S494 RAF1 s155 sa679 rs5
feature: S497 9 RAF1 s155 sa679 rs8
feature: T491 RAF1 s155 sa679 rs4
feature: S338 RAF1 s155 sa679 rs1
feature: S621 RAF1 s155 sa679 rs9
feature: S259 RAF1 s155 sa679 rs3
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JUN-RIGHT__JUN-_re166
controller: MAPK8-10

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63000 74
xref: PTHR24072:SF105
organism: Homo sapiens

TRANSPORT_LEFT__PRKD2-RIGHT__PRKD2-_re534
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re534 1003
participant stoichiometry: PARTICIPANT STOICHIOMETRY re534 1004
left: PRKD2
interaction type: TRANSPORT
right: PRKD2

P07080
type: UnificationXref
id: P07080
db: PANTHER Pathway Component

Y91 CCK s1910 sa946 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y91
feature location: Y91 CCK s1910 sa946 rs2 Y91
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7668909901804244
comment: MODIFICATION_RESIDUE_NAME=Y91
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

P07089
type: UnificationXref
id: P07089
db: PANTHER Pathway Component

P07088
type: UnificationXref
id: P07088
db: PANTHER Pathway Component

P07085
type: UnificationXref
id: P07085
db: PANTHER Pathway Component

Y527 SRC @Galphaq s1894 sa976 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 SRC @Galphaq s1894 sa976 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.585857905576321
comment: MODIFICATION_RESIDUE_NAME=Y527

P07086
type: UnificationXref
id: P07086
db: PANTHER Pathway Component

P07083
type: UnificationXref
id: P07083
db: PANTHER Pathway Component

P07084
type: UnificationXref
id: P07084
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re446 1164
type: Stoichiometry
physical entity: PRKD2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re534 1003
type: Stoichiometry
physical entity: PRKD2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re446 1165
type: Stoichiometry
physical entity: PRKD2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re534 1004
type: Stoichiometry
physical entity: PRKD2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re365 511
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SHC-RIGHT__SHC2-_re526
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re526 1042
participant stoichiometry: PARTICIPANT STOICHIOMETRY re526 1041
left: SHC
interaction type: STATE_TRANSITION
right: SHC2

PARTICIPANT STOICHIOMETRY re365 512
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

TFF2
type: DnaRegion
entity reference: TFF2
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Gbeta/gamma
type: Complex
component stoichiometry: Ggamma s1371 sa697 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s1372 sa698 STOICHIOMETRY ID COMPLEX
component: Gbeta
component: Ggamma
feature: COMPLEX BINDING FEATURE s2020 csa63 209
feature: COMPLEX BINDING FEATURE s2020 csa63 211
cellular location: CELL

P07071
type: UnificationXref
id: P07071
db: PANTHER Pathway Component

P07072
type: UnificationXref
id: P07072
db: PANTHER Pathway Component

P07073
type: UnificationXref
id: P07073
db: PANTHER Pathway Component

P07074
type: UnificationXref
id: P07074
db: PANTHER Pathway Component

Galpha13 s135 sa577 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galpha13
stoichiometric coefficient: 1.0

P07075
type: UnificationXref
id: P07075
db: PANTHER Pathway Component

KNOWN_TRANSITION_OMITTED_LEFT__CCK_22-RIGHT__CCK-_re492
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re492 1025
participant stoichiometry: PARTICIPANT STOICHIOMETRY re492 1026
left: CCK-22
interaction type: KNOWN_TRANSITION_OMITTED
right: CCK

P07076
type: UnificationXref
id: P07076
db: PANTHER Pathway Component

P07077
type: UnificationXref
id: P07077
db: PANTHER Pathway Component

uniprot P31749 127
type: UnificationXref
id: P31749
db: uniprot

P07078
type: UnificationXref
id: P07078
db: PANTHER Pathway Component

P07079
type: UnificationXref
id: P07079
db: PANTHER Pathway Component

Y317 p66 SHC1 s728 sa99 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y317
feature location: Y317 p66 SHC1 s728 sa99 rs1 Y317
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y317
comment: MODIFICATION_RESIDUE_ANGLE=0.756380989872912

PARTICIPANT STOICHIOMETRY re533 1006
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 2.0

Baculoviral IAP repeat-containing protein 2
type: DnaReference
xref: PTHR10044:SF79
organism: Homo sapiens

Baculoviral IAP repeat-containing protein 3
type: DnaReference
xref: PTHR10044:SF99
organism: Homo sapiens

uniprot P46695 55
type: UnificationXref
id: P46695
db: uniprot

PARTICIPANT STOICHIOMETRY re496 1020
type: Stoichiometry
physical entity: CCK-33
stoichiometric coefficient: 1.0

JUN
type: DnaRegionReference
member entity reference: Transcription factor AP-1
xref: G07276
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.JUN

PARTICIPANT STOICHIOMETRY re533 1005
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 2.0

G17 s1411 sa569 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G17
stoichiometric coefficient: 1.0

P07060
type: UnificationXref
id: P07060
db: PANTHER Pathway Component

T359 RSK1 2 s537 sa211 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T359
feature location: T359 RSK1 2 s537 sa211 rs2 T359
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=T359
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7908334448050431

P07063
type: UnificationXref
id: P07063
db: PANTHER Pathway Component

P07061
type: UnificationXref
id: P07061
db: PANTHER Pathway Component

Protein-tyrosine sulfotransferase 1
type: ProteinReference
xref: PTHR12788:SF4
xref: uniprot O60507 113
organism: Homo sapiens

P07062
type: UnificationXref
id: P07062
db: PANTHER Pathway Component

P07067
type: UnificationXref
id: P07067
db: PANTHER Pathway Component

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__HDC-RIGHT__HDC-_re437
controller: GAS-REBP1

P07068
type: UnificationXref
id: P07068
db: PANTHER Pathway Component

P07065
type: UnificationXref
id: P07065
db: PANTHER Pathway Component

EGR1
type: ProteinReference
xref: P07192
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.EGR1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Early growth response protein 1

EIF4E
type: Protein
entity reference: EIF4E
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

uniprot Q15717 149
type: UnificationXref
id: Q15717
db: uniprot

P07069
type: UnificationXref
id: P07069
db: PANTHER Pathway Component

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot Q08209 156
organism: Homo sapiens

SP1
type: ProteinReference
xref: P07203
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.SP1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Transcription factor Sp1

AKT1
type: Protein
entity reference: AKT1
feature: T308 AKT1 s1739 sa165 rs1
feature: S473 AKT1 s1739 sa165 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re496 1019
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

PLCgamma1
type: Protein
entity reference: PLCgamma1
feature: Y472 PLCgamma1 s1622 sa903 rs1
feature: Y771 PLCgamma1 s1622 sa903 rs2
feature: Y783 PLCgamma1 s1622 sa903 rs3
feature: Y1254 PLCgamma1 s1622 sa903 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RAC1_GDP-_GTP-RIGHT__RAC1_GTP-_GDP-_re76
controller: GEF

Y580 FAK2 s1204 sa520 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y580
feature location: Y580 FAK2 s1204 sa520 rs3 Y580
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y580
comment: MODIFICATION_RESIDUE_ANGLE=0.75

uniprot P98171 54
type: UnificationXref
id: P98171
db: uniprot

CXCL1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.CXCL1
comment: ENTITY_REFERENCE_NOTES=

Y580 FAK2 s1892 sa975 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y580
feature location: Y580 FAK2 s1892 sa975 rs3 Y580
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y580
comment: MODIFICATION_RESIDUE_ANGLE=0.75

uniprot P45983 68
type: UnificationXref
id: P45983
db: uniprot

S32 FOS s1040 sa339 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S32
feature location: S32 FOS s1040 sa339 rs2 S32
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S32
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.845512436090568

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CaMKIV-RIGHT__CaMKIV-_re666
controller: CaMKK

S437 CCK2R s1688 sa565 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S437
feature location: S437 CCK2R s1688 sa565 rs4 S437
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S437
comment: MODIFICATION_RESIDUE_ANGLE=3.6969103423572474
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

T440 CCK2R s1660 sa22 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T440
feature location: T440 CCK2R s1660 sa22 rs8 T440
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.06610690323832
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T440

P07059
type: UnificationXref
id: P07059
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__mTORC1_complex-RIGHT__mTORC1_complex-_re112
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re112 1099
participant stoichiometry: PARTICIPANT STOICHIOMETRY re112 1100
left: mTORC1 complex
interaction type: STATE_TRANSITION
right: mTORC1 complex

P07055
type: UnificationXref
id: P07055
db: PANTHER Pathway Component

P07054
type: UnificationXref
id: P07054
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__mTORC1_complex-RIGHT__mTORC1_complex-_re116
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re116 1092
participant stoichiometry: PARTICIPANT STOICHIOMETRY re116 1091
left: mTORC1 complex
interaction type: STATE_TRANSITION
right: mTORC1 complex

T538 PKCtheta s1796 sa642 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T538
feature location: T538 PKCtheta s1796 sa642 rs1 T538
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T538
comment: MODIFICATION_RESIDUE_ANGLE=2.34

P07057
type: UnificationXref
id: P07057
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__mTORC1_complex-RIGHT__mTORC1_complex-_re115
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re115 1094
participant stoichiometry: PARTICIPANT STOICHIOMETRY re115 1093
left: mTORC1 complex
interaction type: STATE_TRANSITION
right: mTORC1 complex

Y577 FAK1 s668 sa118 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y577
feature location: Y577 FAK1 s668 sa118 rs4 Y577
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.29
comment: MODIFICATION_RESIDUE_NAME=Y577

Y527 SRC @Galphaq s1599 sa887 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 SRC @Galphaq s1599 sa887 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.585857905576321
comment: MODIFICATION_RESIDUE_NAME=Y527

P07053
type: UnificationXref
id: P07053
db: PANTHER Pathway Component

FOXO1
type: ProteinReference
xref: P07167
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.FOXO1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Forkhead box protein O1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PDPK1-RIGHT__PDPK1-_re105
controller: PDPK1

PARTICIPANT STOICHIOMETRY re155 944
type: Stoichiometry
physical entity: p38MAPK s998 sa227
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re155 943
type: Stoichiometry
physical entity: p38MAPK
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__CCK1R-_CCK-RIGHT__CCK1R__active_-_re286
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re286 572
participant stoichiometry: PARTICIPANT STOICHIOMETRY re286 571
participant stoichiometry: PARTICIPANT STOICHIOMETRY re286 573
left: CCK1R
left: CCK
interaction type: HETERODIMER_ASSOCIATION
right: CCK1R (active)

S218 MAP2K2 s824 sa205 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S218
feature location: S218 MAP2K2 s824 sa205 rs2 S218
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.536813139478905
comment: MODIFICATION_RESIDUE_NAME=S218

SHP-2
type: Protein
entity reference: SHP-2
feature: Y580 SHP 2 s1441 sa634 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re179 854
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re179 855
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 2.0

Caspase-3
type: ProteinReference
xref: P07108
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Caspase-3
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Caspase-3

S241 PDPK1 s1669 sa163 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S241
feature location: S241 PDPK1 s1669 sa163 rs1 S241
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=0.7668909901804244
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S241

PARTICIPANT STOICHIOMETRY re448 1160
type: Stoichiometry
physical entity: HDAC7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re448 1161
type: Stoichiometry
physical entity: HDAC7
stoichiometric coefficient: 1.0

RPTOR s954 sa309 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RPTOR
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IkB_kinase_complex-RIGHT__IkB_kinase_complex-_re38
controller: MAP3K14

EGR1
type: Protein
entity reference: EGR1
feature: EGR1 s1797 sa962 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TFF2
type: DnaRegionReference
member entity reference: HGNC_11756
xref: G07264
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.TFF2
comment: ENTITY_REFERENCE_NOTES=

P07049
type: UnificationXref
id: P07049
db: PANTHER Pathway Component

P07048
type: UnificationXref
id: P07048
db: PANTHER Pathway Component

P07047
type: UnificationXref
id: P07047
db: PANTHER Pathway Component

Y527 p60 SRC s963 sa286 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 p60 SRC s963 sa286 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y527
comment: MODIFICATION_RESIDUE_ANGLE=5.537766360638166

TRANSPORT_LEFT__TACR1-RIGHT__TACR1-_re512
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re512 1080
participant stoichiometry: PARTICIPANT STOICHIOMETRY re512 1081
left: TACR1
interaction type: TRANSPORT
right: TACR1

P07045
type: UnificationXref
id: P07045
db: PANTHER Pathway Component

P07044
type: UnificationXref
id: P07044
db: PANTHER Pathway Component

BAD/BCL2 heterodimer
type: Complex
component stoichiometry: BCL2 s1562 sa856 STOICHIOMETRY ID COMPLEX
component stoichiometry: BAD s1565 sa857 STOICHIOMETRY ID COMPLEX
component: BAD
component: BCL2
feature: COMPLEX BINDING FEATURE s1968 csa69 239
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s1968 csa69 241
cellular location: Mitochondria

P07042
type: UnificationXref
id: P07042
db: PANTHER Pathway Component

cAMP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1534 sa839 462
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P07041
type: UnificationXref
id: P07041
db: PANTHER Pathway Component

P07040
type: UnificationXref
id: P07040
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re504 1110
type: Stoichiometry
physical entity: CALCA
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RPS6-RIGHT__RPS6-_re117
controller: p70S6K1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RSK1_2-RIGHT__RSK1_2-_re146
controller: PDPK1

Transforming protein RhoA
type: ProteinReference
xref: PTHR24072:SF153
xref: uniprot P61586 9
organism: Homo sapiens

MEF2
type: ProteinReference
xref: P07032
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MEF2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Myocyte-specific enhancer factor 2D

uniprot Q13163 14
type: UnificationXref
id: Q13163
db: uniprot

PKCepsilon
type: ProteinReference
xref: P07054
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PKC_epsilon_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein kinase C epsilon type

BCL2
type: Protein
entity reference: BCL2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1771 sa289 238
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

NFKB1-RELA-IKB complex
type: Complex
component stoichiometry: NFKB RELA heterodimer s1942 csa82 STOICHIOMETRY ID COMPLEX
component stoichiometry: IKBalpha s844 sa252 STOICHIOMETRY ID COMPLEX
component: IKBalpha
component: NFKB RELA heterodimer s1942 csa82
feature: COMPLEX BINDING FEATURE s1944 csa2 359
feature: COMPLEX BINDING FEATURE s1944 csa2 357
cellular location: CELL

PARTICIPANT STOICHIOMETRY re384 1190
type: Stoichiometry
physical entity: NFKB1-RELA-IKB complex
stoichiometric coefficient: 1.0

P07037
type: UnificationXref
id: P07037
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re384 1191
type: Stoichiometry
physical entity: NFKB/RELA heterodimer
stoichiometric coefficient: 1.0

P07036
type: UnificationXref
id: P07036
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re384 1192
type: Stoichiometry
physical entity: IKBalpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re557 934
type: Stoichiometry
physical entity: Caspase-3
stoichiometric coefficient: 1.0

P07039
type: UnificationXref
id: P07039
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re557 933
type: Stoichiometry
physical entity: Pro-caspase-3
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__G34-RIGHT__G17-_re45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re45 772
participant stoichiometry: PARTICIPANT STOICHIOMETRY re45 771
left: G34
interaction type: STATE_TRANSITION
right: G17

P07038
type: UnificationXref
id: P07038
db: PANTHER Pathway Component

RAF1
type: Protein
entity reference: RAF1
feature: S494 RAF1 s1721 sa694 rs5
feature: Y341 RAF1 s1721 sa694 rs2
feature: S621 RAF1 s1721 sa694 rs9
feature: S43 RAF1 s1721 sa694 rs6
feature: T491 RAF1 s1721 sa694 rs4
feature: S338 RAF1 s1721 sa694 rs1
feature: S259 RAF1 s1721 sa694 rs3
feature: S497 9 RAF1 s1721 sa694 rs8
feature: T268 9 RAF1 s1721 sa694 rs7
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

P07031
type: UnificationXref
id: P07031
db: PANTHER Pathway Component

BAD/BCL2 heterodimer
type: Complex
component stoichiometry: BCL2 s1771 sa289 STOICHIOMETRY ID COMPLEX
component stoichiometry: BAD s1561 sa290 STOICHIOMETRY ID COMPLEX
component: BAD
component: BCL2
feature: COMPLEX BINDING FEATURE s1967 csa16 237
feature: COMPLEX BINDING FEATURE s1967 csa16 235
cellular location: Mitochondria

RHEB-GDP
type: ProteinReference
xref: P07175
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RHEB-GDP
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: GTP-binding protein Rheb

P07033
type: UnificationXref
id: P07033
db: PANTHER Pathway Component

P07032
type: UnificationXref
id: P07032
db: PANTHER Pathway Component

CCK s1910 sa946 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

G17
type: Protein
entity reference: G17
feature: ACTIVE 13
feature: Y G17 s1417 sa559 rs1
cellular location: Late endosome
comment: SPECIES_TYPE=PROTEIN

P07035
type: UnificationXref
id: P07035
db: PANTHER Pathway Component

P07034
type: UnificationXref
id: P07034
db: PANTHER Pathway Component

uniprot P54750 144
type: UnificationXref
id: P54750
db: uniprot

T439 CCK2R s1369 sa563 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T439
feature location: T439 CCK2R s1369 sa563 rs6 T439
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.751588888718252
comment: MODIFICATION_RESIDUE_NAME=T439

Growth-regulated alpha protein
type: DnaReference
xref: PTHR10179:SF69
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re504 1109
type: Stoichiometry
physical entity: CALCA s1845 sa796
stoichiometric coefficient: 1.0

p85
type: ProteinReference
xref: P07212
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p85
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Phosphatidylinositol 3-kinase regulatory subunit alpha

C-X-C motif chemokine 2
type: DnaReference
xref: PTHR10179:SF80
organism: Homo sapiens

P07028
type: UnificationXref
id: P07028
db: PANTHER Pathway Component

P07027
type: UnificationXref
id: P07027
db: PANTHER Pathway Component

Protein tyrosine sulfotransferase
type: Protein
entity reference: Protein tyrosine sulfotransferase
comment: SPECIES_TYPE=PROTEIN

P07026
type: UnificationXref
id: P07026
db: PANTHER Pathway Component

S45 beta catenin s1315 sa638 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S45
feature location: S45 beta catenin s1315 sa638 rs3 S45
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S45
comment: MODIFICATION_RESIDUE_ANGLE=3.845512436090568

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__FAK1_SRC_complex-RIGHT__FAK1_SRC_p190GEF_complex-_re485
control type: ACTIVATION
controller: p190RhoGEF

P07029
type: UnificationXref
id: P07029
db: PANTHER Pathway Component

P07020
type: UnificationXref
id: P07020
db: PANTHER Pathway Component

T334 MAPKAP K2 s1583 sa870 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T334
feature location: T334 MAPKAP K2 s1583 sa870 rs3 T334
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T334
comment: MODIFICATION_RESIDUE_ANGLE=0.7737547943982948

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLA2-RIGHT__PLA2-_re542
controller: CCK2R

S259 RAF1 s154 sa685 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S259
feature location: S259 RAF1 s154 sa685 rs3 S259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S259
comment: MODIFICATION_RESIDUE_ANGLE=2.328231397687482

IP3R
type: ProteinReference
xref: P07123
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.ION_CHANNEL.IP_sub_3_endsub_R
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1

Y91 CCK s1779 sa948 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y91
feature location: Y91 CCK s1779 sa948 rs2 Y91
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7668909901804244
comment: MODIFICATION_RESIDUE_NAME=Y91
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

P07022
type: UnificationXref
id: P07022
db: PANTHER Pathway Component

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s136 sa578 196
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P07021
type: UnificationXref
id: P07021
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__MEF2-RIGHT__MEF2-_re631
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re631 747
participant stoichiometry: PARTICIPANT STOICHIOMETRY re631 748
left: MEF2
interaction type: STATE_TRANSITION
right: MEF2

ICER
type: ProteinReference
xref: P07027
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.ICER
comment: ENTITY_REFERENCE_NOTES=
member entity reference: cAMP-responsive element modulator

BCL2L1 s1613 sa895 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BCL2L1
stoichiometric coefficient: 1.0

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
type: ProteinReference
xref: PTHR12305:SF81
xref: uniprot P60484 67
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re150 952
type: Stoichiometry
physical entity: MAP2K4 s995 sa219
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re150 951
type: Stoichiometry
physical entity: MAP2K4
stoichiometric coefficient: 1.0

p38MAPK
type: Protein
entity reference: p38MAPK
feature: Y182 p38MAPK s144 sa225 rs1
feature: T180 p38MAPK s144 sa225 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S497 9 RAF1 s154 sa685 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S497 9
feature location: S497 9 RAF1 s154 sa685 rs8 S497 9
comment: MODIFICATION_RESIDUE_ANGLE=6.261510357865046
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S497/9

PARTICIPANT STOICHIOMETRY re579 840
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

mTORC1 complex
type: Complex
component stoichiometry: mLST8 s1767 sa310 STOICHIOMETRY ID COMPLEX
component stoichiometry: RPTOR s954 sa309 STOICHIOMETRY ID COMPLEX
component stoichiometry: mTOR s924 sa308 STOICHIOMETRY ID COMPLEX
component: mLST8
component: mTOR
component: RPTOR
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s1766 csa25 185
feature: COMPLEX BINDING FEATURE s1766 csa25 181
feature: COMPLEX BINDING FEATURE s1766 csa25 183
cellular location: CELL

uniprot O60674 18
type: UnificationXref
id: O60674
db: uniprot

PARTICIPANT STOICHIOMETRY re284 580
type: Stoichiometry
physical entity: s855
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__FOS-RIGHT__s1792-_re622
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re622 789
participant stoichiometry: PARTICIPANT STOICHIOMETRY re622 790
left: FOS
interaction type: STATE_TRANSITION
right: s1792

PARTICIPANT STOICHIOMETRY re579 838
type: Stoichiometry
physical entity: BAD/BCL2L1 heterodimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re579 839
type: Stoichiometry
physical entity: BCL2L1
stoichiometric coefficient: 1.0

s1447
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=DEGRADED

Y416 p60 SRC s880 sa97 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 p60 SRC s880 sa97 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.8018247916515125

T440 CCK2R s1688 sa565 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T440
feature location: T440 CCK2R s1688 sa565 rs8 T440
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.06610690323832
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T440

p190RhoGEF
type: Protein
entity reference: p190RhoGEF
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re644 703
type: Stoichiometry
physical entity: REG1A
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re644 704
type: Stoichiometry
physical entity: REG1A
stoichiometric coefficient: 1.0

SHC2
type: Protein
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

FOS s1040 sa339 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

CCK1R s1483 sa454 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CCK1R
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRKD2-RIGHT__PRKD2-_re416
controller: PKCeta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re408
controller: PAK s735 sa678

PKA-R1alpha/beta
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1519 sa829 320
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR11903:SF8
type: RelationshipXref
id: PTHR11903:SF8
db: PANTHER Family
relationship type: By Homology

INHIBITION
type: Control
xref: INHIBITION
controlled: TRANSPORT_LEFT__Cytochrome_C-RIGHT__Cytochrome_C-_re633
control type: INHIBITION
controller: BCL2

S82 CCK2R s1235 sa558 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S82
feature location: S82 CCK2R s1235 sa558 rs2 S82
comment: MODIFICATION_RESIDUE_ANGLE=2.827433388230814
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S82

STATE_TRANSITION_LEFT__JUN-RIGHT__s1787-_re619
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re619 826
participant stoichiometry: PARTICIPANT STOICHIOMETRY re619 827
left: JUN
interaction type: STATE_TRANSITION
right: s1787

S221 HuR s1380 sa723 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 HuR s1380 sa723 rs2 S221
comment: MODIFICATION_RESIDUE_ANGLE=5.58
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221

TRANSCRIPTION_LEFT__MMP7-RIGHT__MMP7-_re418
type: TemplateReaction
product: MMP7
xref: TRANSCRIPTION
participant: MMP7
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

RPS6 s659 sa169 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.786798160123647

PTHR13715:SF75
type: RelationshipXref
id: PTHR13715:SF75
db: PANTHER Family
relationship type: By Homology

S2481 mTOR s958 sa316 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S2481
feature location: S2481 mTOR s958 sa316 rs2 S2481
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8251814037002603
comment: MODIFICATION_RESIDUE_NAME=S2481

IEX1
type: Protein
entity reference: IEX1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

IEX1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.IEX1
comment: ENTITY_REFERENCE_NOTES=

uniprot Q14814 125
type: UnificationXref
id: Q14814
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p46_SHC1-RIGHT__p46_SHC1-_re60
controller: PKC

STATE_TRANSITION_LEFT__SNAI1-RIGHT__SNAI1-_re129
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re129 1052
participant stoichiometry: PARTICIPANT STOICHIOMETRY re129 1051
left: SNAI1
interaction type: STATE_TRANSITION
right: SNAI1

S442 CCK2R s1369 sa563 rs10
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S442
feature location: S442 CCK2R s1369 sa563 rs10 S442
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=6.097097937454755
comment: MODIFICATION_RESIDUE_NAME=S442

TAC1
type: DnaRegion
entity reference: TAC1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY re284 579
type: Stoichiometry
physical entity: CCK s1780 sa949
stoichiometric coefficient: 1.0

GRB2 s942 sa271 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GRB2 s942 sa271
stoichiometric coefficient: 1.0

Serum response factor
type: ProteinReference
xref: PTHR48019:SF40
xref: uniprot P11831 98
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re162 926
type: Stoichiometry
physical entity: MAP2K5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re419 1199
type: Stoichiometry
physical entity: MMP7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re162 927
type: Stoichiometry
physical entity: MAP2K5
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__MAPK1_3-RIGHT__MAPK1_3-_re537
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re537 998
participant stoichiometry: PARTICIPANT STOICHIOMETRY re537 997
left: MAPK1/3
interaction type: TRANSPORT
right: MAPK1/3

Y341 RAF1 s731 sa687 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y341
feature location: Y341 RAF1 s731 sa687 rs2 Y341
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y341
comment: MODIFICATION_RESIDUE_ANGLE=0.813361255902311

PLA2
type: ProteinReference
xref: P07086
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PLA2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cytosolic phospholipase A2

STATE_TRANSITION_LEFT__p66_SHC1-RIGHT__p66_SHC1-_re61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 700
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 699
left: p66 SHC1
interaction type: STATE_TRANSITION
right: p66 SHC1

Y317 p46 SHC1 s1781 sa103 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y317
feature location: Y317 p46 SHC1 s1781 sa103 rs1 Y317
comment: MODIFICATION_RESIDUE_ANGLE=0.7243274201314622
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y317

MOB1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.MOB1
comment: ENTITY_REFERENCE_NOTES=

NAD+
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

S63 JUN s1859 sa235 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S63
feature location: S63 JUN s1859 sa235 rs1 S63
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8251814037002603
comment: MODIFICATION_RESIDUE_NAME=S63

B-Raf
type: Protein
entity reference: B-Raf
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__TFF1-RIGHT__TFF1-_re248
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re248 706
participant stoichiometry: PARTICIPANT STOICHIOMETRY re248 705
left: TFF1
interaction type: TRANSPORT
right: TFF1

HDC
type: RnaRegion
entity reference: HDC
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

STATE_TRANSITION_LEFT__SNAI1-RIGHT__SNAI1-_re130
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re130 1032
participant stoichiometry: PARTICIPANT STOICHIOMETRY re130 1031
left: SNAI1
interaction type: STATE_TRANSITION
right: SNAI1

Y1254 PLCgamma1 s1622 sa903 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y1254
feature location: Y1254 PLCgamma1 s1622 sa903 rs4 Y1254
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y1254
comment: MODIFICATION_RESIDUE_ANGLE=5.61

NFKB1/RELA heterodimer
type: Complex
component stoichiometry: RELA p65 s1682 sa328 STOICHIOMETRY ID COMPLEX
component stoichiometry: NFKB1 p50 s1681 sa327 STOICHIOMETRY ID COMPLEX
component: NFKB1 (p50)
component: RELA (p65)
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s1979 csa33 285
feature: COMPLEX BINDING FEATURE s1979 csa33 283
cellular location: NUCLEUS

S260 CCK1R s1483 sa454 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S260
feature location: S260 CCK1R s1483 sa454 rs1 S260
comment: MODIFICATION_RESIDUE_NAME=S260
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8807084252156057

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RYR1_2_3-RIGHT__RYR1_2_3-_re515
controller: Caffeine

TRANSPORT_LEFT__IEX1-RIGHT__IEX1-_re609
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re609 879
participant stoichiometry: PARTICIPANT STOICHIOMETRY re609 878
left: IEX1
interaction type: TRANSPORT
right: IEX1

SRF
type: Protein
entity reference: SRF
feature: ACTIVE 13
feature: S103 SRF s1061 sa747 rs1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Progastrin_@ER___Golgi-RIGHT__Progastrin_@Golgi-_re478
controller: Carboxypeptidase E

PARTICIPANT STOICHIOMETRY re52 725
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

Galpha q complex
type: Complex
component stoichiometry: Galpha q s22 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s1775 sa23 STOICHIOMETRY ID COMPLEX
component: GTP
component: Galpha q
feature: COMPLEX BINDING FEATURE s1899 csa77 379
feature: COMPLEX BINDING FEATURE s1899 csa77 381
cellular location: CELL

Signalase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re52 726
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

T268 9 RAF1 s1336 sa692 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T268 9
feature location: T268 9 RAF1 s1336 sa692 rs7 T268 9
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T268/9
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Y1148 EGFR s727 sa266 rs11
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y1148
feature location: Y1148 EGFR s727 sa266 rs11 Y1148
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.24116495329281254
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y1148

G Protein complex
type: Complex
component stoichiometry: Ggamma s21 sa250 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s687 sa251 STOICHIOMETRY ID COMPLEX
component stoichiometry: Galpha q s686 sa248 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s20 sa249 STOICHIOMETRY ID COMPLEX
component: GDP
component: Ggamma
component: Galpha q
component: Gbeta
feature: COMPLEX BINDING FEATURE s1898 csa1 293
feature: COMPLEX BINDING FEATURE s1898 csa1 291
feature: COMPLEX BINDING FEATURE s1898 csa1 289
feature: COMPLEX BINDING FEATURE s1898 csa1 287
cellular location: CELL

PARTICIPANT STOICHIOMETRY re41 777
type: Stoichiometry
physical entity: IKBalpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re41 778
type: Stoichiometry
physical entity: sa342_degraded
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRAS40-RIGHT__PRAS40-_re122
controller: mTORC2 complex

PTHR10740:SF4
type: RelationshipXref
id: PTHR10740:SF4
db: PANTHER Family
relationship type: By Homology

S70 FOS s202 sa233 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S70
feature location: S70 FOS s202 sa233 rs4 S70
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S70
comment: MODIFICATION_RESIDUE_ANGLE=5.5330859376426975

PTHR24264:SF38
type: RelationshipXref
id: PTHR24264:SF38
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__CXCL1-RIGHT__CXCL1-_re449
controller: NFKB1/RELA heterodimer

ARHGAP4
type: ProteinReference
xref: P07135
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.ARHGAP4
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Rho GTPase-activating protein 4

Y771 PLCgamma1 s716 sa18 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y771
feature location: Y771 PLCgamma1 s716 sa18 rs2 Y771
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y771
comment: MODIFICATION_RESIDUE_ANGLE=2.4116017680334347

ATF2
type: Protein
entity reference: ATF2 PROTEIN
feature: ACTIVE 13
feature: T71 ATF2 s1012 sa753 rs2
feature: T69 ATF2 s1012 sa753 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Preprogastrin_@ER-RIGHT__Progastrin_@ER___Golgi-_re42
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 774
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 773
left: Preprogastrin @ER
interaction type: STATE_TRANSITION
right: Progastrin @ER - Golgi

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK2-RIGHT__FAK2-_re309
controller: PKCtheta

ATF2
type: Protein
entity reference: ATF2 PROTEIN
feature: COMPLEX PARTICIPANT BINDING FEATURE s1051 sa350 348
feature: T71 ATF2 s1051 sa350 rs2
feature: T69 ATF2 s1051 sa350 rs1
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__HDC-RIGHT__HDC-_re437
controller: GAS REBP2 s1639 sa917

PKA Calpha beta gamma s1521 sa832 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKA-Calpha/beta/gamma
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__MAPK7-RIGHT__MAPK7-_re535
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re535 1001
participant stoichiometry: PARTICIPANT STOICHIOMETRY re535 1002
left: MAPK7
interaction type: TRANSPORT
right: MAPK7

PARTICIPANT STOICHIOMETRY re46 768
type: Stoichiometry
physical entity: G17
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re46 767
type: Stoichiometry
physical entity: G17 - Gly
stoichiometric coefficient: 1.0

BCL2L1
type: Protein
entity reference: BCL2L1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1613 sa895 220
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PPARgamma-RIGHT__PPARgamma-_re483
controller: MAPK1/3

uniprot Q07817 132
type: UnificationXref
id: Q07817
db: uniprot

S154 CCK2R s1369 sa563 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S154
feature location: S154 CCK2R s1369 sa563 rs3 S154
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.234636338452209
comment: MODIFICATION_RESIDUE_NAME=S154

S706 PRKD2 s1820 sa695 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S706
feature location: S706 PRKD2 s1820 sa695 rs2 S706
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S706
comment: MODIFICATION_RESIDUE_ANGLE=0.8559137879749282

PARTICIPANT STOICHIOMETRY re170 877
type: Stoichiometry
physical entity: MAPK7
stoichiometric coefficient: 2.0

HBEGF
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.HBEGF
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re170 876
type: Stoichiometry
physical entity: MAPK7
stoichiometric coefficient: 1.0

ELK1
type: Protein
entity reference: ELK1
feature: S383 ELK1 s197 sa333 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__Beta_arrestin_1_2-_CCK2R-RIGHT__active_CCK2R_beta_arrestin_complex-_re331
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re331 559
participant stoichiometry: PARTICIPANT STOICHIOMETRY re331 558
participant stoichiometry: PARTICIPANT STOICHIOMETRY re331 557
left: Beta-arrestin-1/2
left: CCK2R
interaction type: HETERODIMER_ASSOCIATION
right: active CCK2R beta arrestin complex s1687 csa54

STATE_TRANSITION_LEFT__MAP2K6-RIGHT__MAP2K6-_re151
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re151 949
participant stoichiometry: PARTICIPANT STOICHIOMETRY re151 950
left: MAP2K6
interaction type: STATE_TRANSITION
right: MAP2K6

S437 CCK2R s1235 sa558 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S437
feature location: S437 CCK2R s1235 sa558 rs4 S437
comment: MODIFICATION_RESIDUE_NAME=S437
comment: MODIFICATION_RESIDUE_ANGLE=3.6969103423572474
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

B-Raf
type: Protein
entity reference: B-Raf
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y764 CAS s765 sa116 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y764
feature location: Y764 CAS s765 sa116 rs2 Y764
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y764
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7892481543944946

TRANSPORT_LEFT__Cytochrome_C-RIGHT__Cytochrome_C-_re633
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re633 743
participant stoichiometry: PARTICIPANT STOICHIOMETRY re633 742
left: Cytochrome C
interaction type: TRANSPORT
right: Cytochrome C

PARTICIPANT STOICHIOMETRY re318 586
type: Stoichiometry
physical entity: FAK2-SRC complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re318 585
type: Stoichiometry
physical entity: CRK
stoichiometric coefficient: 1.0

MOB1
type: DnaRegionReference
member entity reference: MOB kinase activator 1A
xref: G07283
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.MOB1
comment: ENTITY_REFERENCE_NOTES=

PRKD1
type: Protein
entity reference: PRKD1
feature: S744 PRKD1 s662 sa41 rs1
feature: ACTIVE 13
feature: S748 PRKD1 s662 sa41 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re318 587
type: Stoichiometry
physical entity: FAK2-SRC-CRK complex
stoichiometric coefficient: 1.0

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q07889 110
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re140 991
type: Stoichiometry
physical entity: MAP2K1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 919
type: Stoichiometry
physical entity: PKCzeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re140 992
type: Stoichiometry
physical entity: MAP2K1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 918
type: Stoichiometry
physical entity: PKCzeta
stoichiometric coefficient: 1.0

AKT1 s905 sa305 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AKT1
stoichiometric coefficient: 1.0

PKA R2alpha beta s1520 sa830 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKA-R2alpha/beta
stoichiometric coefficient: 1.0

Y725 STAT3 s676 sa323 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y725
feature location: Y725 STAT3 s676 sa323 rs2 Y725
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.583002134385839
comment: MODIFICATION_RESIDUE_NAME=Y725
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

MAPK7 s1972 sa990 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAPK7
stoichiometric coefficient: 2.0

T32 FOXO3 s1991 sa995 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T32
feature location: T32 FOXO3 s1991 sa995 rs3 T32
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.792898447626701
comment: MODIFICATION_RESIDUE_NAME=T32

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI4,5_P2-RIGHT__PI3,4,5_P3-_re103
controller: IRS1 / PI3K association

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Novel_PKC-RIGHT__Novel_PKC-_re21
control type: ACTIVATION
controller: DAG

HETERODIMER_ASSOCIATION_LEFT__FAK2_SRC_complex-_GRB2-RIGHT__FAK2_SRC_GRB2_complex-_re317
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re317 589
participant stoichiometry: PARTICIPANT STOICHIOMETRY re317 588
participant stoichiometry: PARTICIPANT STOICHIOMETRY re317 590
left: GRB2
left: FAK2-SRC complex
interaction type: HETERODIMER_ASSOCIATION
right: FAK2-SRC-GRB2 complex

RAF
type: Protein
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S719 RPTOR s643 sa312 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S719
feature location: S719 RPTOR s643 sa312 rs1 S719
comment: MODIFICATION_RESIDUE_NAME=S719
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.6768177721443449

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HuR-RIGHT__HuR-_re441
controller: PKCalpha

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AKT1_PIP3-RIGHT__AKT1_PIP3-_re110
controller: mTORC2 complex

SOS1
type: Protein
entity reference: SOS1
feature: S SOS1 s943 sa272 rs2
feature: T SOS1 s943 sa272 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s943 sa272 260
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

FAK1-SRC-p190GEF complex
type: Complex
component stoichiometry: p60 SRC s1451 sa783 STOICHIOMETRY ID COMPLEX
component stoichiometry: p190RhoGEF s1453 sa785 STOICHIOMETRY ID COMPLEX
component stoichiometry: FAK1 s1450 sa782 STOICHIOMETRY ID COMPLEX
component: p190RhoGEF
component: p60 SRC
component: FAK1
feature: COMPLEX BINDING FEATURE s1947 csa64 401
feature: COMPLEX BINDING FEATURE s1947 csa64 399
feature: COMPLEX BINDING FEATURE s1947 csa64 403
cellular location: CELL

IEX1
type: DnaRegion
entity reference: IEX1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Two pore calcium channel protein 1
type: ProteinReference
xref: uniprot Q9ULQ1 53
xref: PTHR46474:SF1
organism: Homo sapiens

Y94 CCK s1780 sa949 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 CCK s1780 sa949 rs3 Y94
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.474173865666921
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y94

EGR1 s1797 sa962 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.7383466605211034

Y91 CCK GRR s877 sa501 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y91
feature location: Y91 CCK GRR s877 sa501 rs2 Y91
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_NAME=Y91
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7292982945833448

Beta-arrestin-1/2
type: Protein
entity reference: Beta-arrestin-1/2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1690 sa567 366
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK3-RIGHT__MAPK3-_re142
controller: MAP2K1

RELA p65 s1748 sa265 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Anti-apoptosis
type: Pathway

uniprot P49841 29
type: UnificationXref
id: P49841
db: uniprot

PAK1
type: Protein
entity reference: PAK1
feature: T423 PAK1 s786 sa136 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y579 FAK2 s1604 sa880 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y579
feature location: Y579 FAK2 s1604 sa880 rs2 Y579
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y579
comment: MODIFICATION_RESIDUE_ANGLE=3.84

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

uniprot P51812 119
type: UnificationXref
id: P51812
db: uniprot

S32 FOS s202 sa233 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S32
feature location: S32 FOS s202 sa233 rs2 S32
comment: MODIFICATION_RESIDUE_NAME=S32
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.845512436090568

uniprot P10415 42
type: UnificationXref
id: P10415
db: uniprot

Y390 CCK2R s1369 sa563 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y390
feature location: Y390 CCK2R s1369 sa563 rs1 Y390
comment: MODIFICATION_RESIDUE_ANGLE=2.4010743852436276
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y390

S221 PRAS40 s647 sa173 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 PRAS40 s647 sa173 rs4 S221
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221
comment: MODIFICATION_RESIDUE_ANGLE=3.856865980969612

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NFKB1_RelA_IKB_complex-RIGHT__NFKB1_RELA_IKB_complex-_re39
controller: IkB kinase complex

PARTICIPANT STOICHIOMETRY re535 1002
type: Stoichiometry
physical entity: MAPK7
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re535 1001
type: Stoichiometry
physical entity: MAPK7
stoichiometric coefficient: 2.0

FAK2
type: Protein
entity reference: FAK2
feature: Y402 FAK2 s1204 sa520 rs1
feature: Y579 FAK2 s1204 sa520 rs2
feature: ACTIVE 13
feature: Y580 FAK2 s1204 sa520 rs3
feature: Y881 FAK2 s1204 sa520 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_CATALYSIS
type: RelationshipTypeVocabulary

T219 MAPK7 s1970 sa988 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T219
feature location: T219 MAPK7 s1970 sa988 rs1 T219
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.387506044879286
comment: MODIFICATION_RESIDUE_NAME=T219

PARTICIPANT STOICHIOMETRY re666 620
type: Stoichiometry
physical entity: CaMKIV
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF20
xref: uniprot P45985 15
organism: Homo sapiens

IL8
type: DnaRegionReference
member entity reference: Interleukin-8
xref: G07296
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.IL8
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re378 1210
type: Stoichiometry
physical entity: A-Raf
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 68
xref: PTHR24055:SF222
organism: Homo sapiens

NUCLEUS
type: CellularLocationVocabulary
xref: go GO:0005634 4

S42 FOS s1858 sa234 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S42
feature location: S42 FOS s1858 sa234 rs3 S42
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S42
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

PARTICIPANT STOICHIOMETRY re378 1211
type: Stoichiometry
physical entity: A-Raf
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P45984 69
xref: PTHR24055:SF172
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re531 1011
type: Stoichiometry
physical entity: Galpha q complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re531 1012
type: Stoichiometry
physical entity: LARG
stoichiometric coefficient: 1.0

Y418 SRC @Galphaq s1605 sa879 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y418
feature location: Y418 SRC @Galphaq s1605 sa879 rs3 Y418
comment: MODIFICATION_RESIDUE_NAME=Y418
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3192345766207003

FOS
type: Protein
entity reference: FOS
feature: S70 FOS s202 sa233 rs4
feature: S374 FOS s202 sa233 rs6
feature: S133 FOS s202 sa233 rs5
feature: S32 FOS s202 sa233 rs2
feature: S42 FOS s202 sa233 rs3
feature: S21 FOS s202 sa233 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re666 619
type: Stoichiometry
physical entity: CaMKIV
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GTP-_CDC42_GDP-RIGHT__GDP-_CDC42_GTP-_re78
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 645
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 644
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 643
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 642
left: CDC42-GDP
left: GTP
interaction type: STATE_TRANSITION
right: GDP
right: CDC42-GTP

S181 HDAC7 s1391 sa740 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S181
feature location: S181 HDAC7 s1391 sa740 rs1 S181
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S181
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7963402430732642

uPA
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.uPA
comment: ENTITY_REFERENCE_NOTES=

HSP27
type: Protein
entity reference: HSP27
feature: S15 HSP27 s1586 sa873 rs1
feature: S78 HSP27 s1586 sa873 rs2
feature: S82 HSP27 s1586 sa873 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CCK2R
type: Protein
entity reference: CCK2R
feature: S434 CCK2R s1369 sa563 rs12
feature: T440 CCK2R s1369 sa563 rs8
feature: Y238 CCK2R s1369 sa563 rs7
feature: Y390 CCK2R s1369 sa563 rs1
feature: S437 CCK2R s1369 sa563 rs4
feature: S154 CCK2R s1369 sa563 rs3
feature: Y438 CCK2R s1369 sa563 rs5
feature: S82 CCK2R s1369 sa563 rs2
feature: I441 CCK2R s1369 sa563 rs9
feature: T443 CCK2R s1369 sa563 rs11
feature: T439 CCK2R s1369 sa563 rs6
feature: S442 CCK2R s1369 sa563 rs10
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S207 MAP2K6 s965 sa226 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S207
feature location: S207 MAP2K6 s965 sa226 rs1 S207
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S207
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8161980913738187

CELL
type: CellularLocationVocabulary
xref: go GO:0005623 7

NR4A1
type: DnaRegionReference
member entity reference: Nuclear receptor subfamily 4 group A member 1
xref: G07289
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.NR4A1
comment: ENTITY_REFERENCE_NOTES=

PKA Holoenzyme II
type: Complex
component stoichiometry: PKA R2alpha beta s1520 sa830 STOICHIOMETRY ID COMPLEX
component stoichiometry: PKA Calpha beta gamma s1521 sa832 STOICHIOMETRY ID COMPLEX
component: PKA-R2alpha/beta
component: PKA-Calpha/beta/gamma
feature: COMPLEX BINDING FEATURE s1956 csa66 325
feature: COMPLEX BINDING FEATURE s1956 csa66 323
cellular location: CELL

Mitogen-activated protein kinase kinase kinase 14
type: ProteinReference
xref: uniprot Q99558 62
xref: PTHR48016:SF9
organism: Homo sapiens

S497 9 RAF1 s742 sa680 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S497 9
feature location: S497 9 RAF1 s742 sa680 rs8 S497 9
comment: MODIFICATION_RESIDUE_ANGLE=6.261510357865046
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S497/9

RGS2
type: ProteinReference
xref: P07040
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RGS2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Regulator of G-protein signaling 2

PARTICIPANT STOICHIOMETRY re14 913
type: Stoichiometry
physical entity: PKCzeta
stoichiometric coefficient: 1.0

RSK1/2
type: Protein
entity reference: RSK1/2
feature: S749 RSK1 2 s537 sa211 rs6
feature: T359 RSK1 2 s537 sa211 rs2
feature: T573 RSK1 2 s537 sa211 rs3
feature: S380 RSK1 2 s537 sa211 rs4
feature: S221 RSK1 2 s537 sa211 rs5
feature: S363 RSK1 2 s537 sa211 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED_LEFT__Conventional_PKC-RIGHT__PKC-_re22
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 865
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 864
left: Conventional PKC
interaction type: KNOWN_TRANSITION_OMITTED
right: PKC

PARTICIPANT STOICHIOMETRY re14 912
type: Stoichiometry
physical entity: Atypical PKC
stoichiometric coefficient: 1.0

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

T268 9 RAF1 s1330 sa689 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T268 9
feature location: T268 9 RAF1 s1330 sa689 rs7 T268 9
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T268/9
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P05412 121
type: UnificationXref
id: P05412
db: uniprot

REG1A
type: RnaRegion
entity reference: REG1A
cellular location: CELL
comment: SPECIES_TYPE=RNA

TRANSCRIPTION
type: InteractionVocabulary

S259 RAF1 s1721 sa694 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S259
feature location: S259 RAF1 s1721 sa694 rs3 S259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S259
comment: MODIFICATION_RESIDUE_ANGLE=2.328231397687482

uniprot P11831 98
type: UnificationXref
id: P11831
db: uniprot

cGMP
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR45767:SF1
type: RelationshipXref
id: PTHR45767:SF1
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re538 996
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re538 995
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

PTHR45767:SF4
type: RelationshipXref
id: PTHR45767:SF4
db: PANTHER Family
relationship type: By Homology

NFAT1
type: Protein
entity reference: NFAT1
feature: ACTIVE 13
feature: S NFAT1 s2015 sa1013 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

ETS domain-containing protein Elk-4
type: ProteinReference
xref: PTHR11849:SF21
xref: uniprot P28324 47
organism: Homo sapiens

Y438 CCK2R s1660 sa22 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y438
feature location: Y438 CCK2R s1660 sa22 rs5 Y438
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y438
comment: MODIFICATION_RESIDUE_ANGLE=4.421329661007988
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

T443 CCK2R s1369 sa563 rs11
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T443
feature location: T443 CCK2R s1369 sa563 rs11 T443
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T443
comment: MODIFICATION_RESIDUE_ANGLE=0.25278736068041796

SP3
type: Protein
entity reference: SP3
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PTHR11801:SF2
type: RelationshipXref
id: PTHR11801:SF2
db: PANTHER Family
relationship type: By Homology

PTHR12533:SF4
type: RelationshipXref
id: PTHR12533:SF4
db: PANTHER Family
relationship type: By Homology

PKCepsilon
type: Protein
entity reference: PKCepsilon
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

MEF2
type: Protein
entity reference: MEF2
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

uniprot P23443 124
type: UnificationXref
id: P23443
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__TAK1-RIGHT__TAK1-_re36
controller: TRAF6

TRANSCRIPTION_LEFT__TFF1-RIGHT__TFF1-_re244
type: TemplateReaction
product: TFF1
xref: TRANSCRIPTION
participant: TFF1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

I441 CCK2R s1410 sa568 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY I441
feature location: I441 CCK2R s1410 sa568 rs9 I441
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.567911979799767
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=I441

Y416 SRC @Galphaq s1605 sa879 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 SRC @Galphaq s1605 sa879 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

KNOWN_TRANSITION_OMITTED_LEFT__AKAP-RIGHT__PKA_Holoenzyme_I-_re300
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re300 637
participant stoichiometry: PARTICIPANT STOICHIOMETRY re300 638
left: AKAP
interaction type: KNOWN_TRANSITION_OMITTED
right: PKA Holoenzyme I

PAI1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.PAI1
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re37 813
type: Stoichiometry
physical entity: MAP3K14
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P10398 173
xref: PTHR44329:SF55
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re37 814
type: Stoichiometry
physical entity: MAP3K14
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__B_Raf-RIGHT__B_Raf-_re172
controller: HRAS-GTP

MMP7
type: DnaRegionReference
member entity reference: Matrilysin
xref: G07290
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.MMP7
comment: ENTITY_REFERENCE_NOTES=

IRS1 s911 sa282 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IRS1
stoichiometric coefficient: 1.0

SNAI1
type: Protein
entity reference: SNAI1
feature: S246 SNAI1 s1854 sa190 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

SRF
type: Complex
component stoichiometry: SRF s1061 sa747 STOICHIOMETRY ID COMPLEX
component: SRF
feature: ACTIVE 13
cellular location: NUCLEUS

FOXO1
type: Protein
entity reference: FOXO1
feature: S319 FOXO1 s1624 sa900 rs2
feature: T24 FOXO1 s1624 sa900 rs3
feature: S256 FOXO1 s1624 sa900 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__RHOA_GTP-RIGHT__Pi-_RHOA_GDP-_re75
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re75 653
participant stoichiometry: PARTICIPANT STOICHIOMETRY re75 655
participant stoichiometry: PARTICIPANT STOICHIOMETRY re75 654
left: RHOA-GTP
interaction type: STATE_TRANSITION
right: RHOA-GDP
right: Pi

CCK2R
type: Protein
entity reference: CCK2R
feature: S434 CCK2R s1688 sa565 rs12
feature: T440 CCK2R s1688 sa565 rs8
feature: S437 CCK2R s1688 sa565 rs4
feature: S154 CCK2R s1688 sa565 rs3
feature: I441 CCK2R s1688 sa565 rs9
feature: S442 CCK2R s1688 sa565 rs10
feature: COMPLEX PARTICIPANT BINDING FEATURE s1688 sa565 362
feature: S82 CCK2R s1688 sa565 rs2
feature: ACTIVE 13
feature: Y390 CCK2R s1688 sa565 rs1
feature: T439 CCK2R s1688 sa565 rs6
feature: Y238 CCK2R s1688 sa565 rs7
feature: Y438 CCK2R s1688 sa565 rs5
feature: T443 CCK2R s1688 sa565 rs11
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re164 920
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ELK1-RIGHT__ELK1-_re623
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re623 788
participant stoichiometry: PARTICIPANT STOICHIOMETRY re623 787
left: ELK1
interaction type: STATE_TRANSITION
right: ELK1

PARTICIPANT STOICHIOMETRY re164 921
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

PTHR13715:SF15
type: RelationshipXref
id: PTHR13715:SF15
db: PANTHER Family
relationship type: By Homology

PTHR13715:SF16
type: RelationshipXref
id: PTHR13715:SF16
db: PANTHER Family
relationship type: By Homology

PTHR22599:SF30
type: RelationshipXref
id: PTHR22599:SF30
db: PANTHER Family
relationship type: By Homology

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__YES1-RIGHT__YES1-_re638
controller: PKC

T41 beta catenin s932 sa321 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T41
feature location: T41 beta catenin s932 sa321 rs4 T41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T41
comment: MODIFICATION_RESIDUE_ANGLE=2.3739822534748654

Integrin beta-1
type: ProteinReference
xref: uniprot P05556 131
xref: PTHR10082:SF28
organism: Homo sapiens

PKA-Calpha/beta/gamma
type: Protein
entity reference: PKA-Calpha/beta/gamma
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR23506:SF30
type: RelationshipXref
id: PTHR23506:SF30
db: PANTHER Family
relationship type: By Homology

CCK-33
type: ProteinReference
xref: P07045
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CCK-33
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

S505 PLA2 s1871 sa825 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S505
feature location: S505 PLA2 s1871 sa825 rs2 S505
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S505

JUN
type: RnaRegion
entity reference: JUN
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

sulfated residue
type: SequenceModificationVocabulary
xref: 00695
comment: DATA_SOURCE=CellDesigner

PARTICIPANT STOICHIOMETRY re637 733
type: Stoichiometry
physical entity: LYN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re637 734
type: Stoichiometry
physical entity: LYN
stoichiometric coefficient: 1.0

uniprot P45984 69
type: UnificationXref
id: P45984
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p46_SHC1-RIGHT__p46_SHC1-_re60
controller: PKCalpha

Y91 CCK s1750 sa789 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y91
feature location: Y91 CCK s1750 sa789 rs2 Y91
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7668909901804244
comment: MODIFICATION_RESIDUE_NAME=Y91
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

CLU
type: DnaRegion
entity reference: CLU
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FOXO1-RIGHT__FOXO1-_re581
controller: AKT1-PIP3

uniprot P46108 105
type: UnificationXref
id: P46108
db: uniprot

TRANSPORT_LEFT__Complex__GRB2_SOS1_-RIGHT__Complex__GRB2_SOS1_-_re65
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re65 689
participant stoichiometry: PARTICIPANT STOICHIOMETRY re65 688
left: Complex (GRB2/SOS1)
interaction type: TRANSPORT
right: Complex (GRB2/SOS1)

STATE_TRANSITION_LEFT__PKCbeta-RIGHT__PKCbeta-_re380
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re380 1198
participant stoichiometry: PARTICIPANT STOICHIOMETRY re380 1197
left: PKCbeta
interaction type: STATE_TRANSITION
right: PKCbeta

SHC1
type: Protein
entity reference: SHC1
feature: Y317 SHC1 s708 sa107 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

uniprot Q13164 136
type: UnificationXref
id: Q13164
db: uniprot

PI3,4,5 P3 s907 sa302 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3,4,5 P3 s907 sa302
stoichiometric coefficient: 1.0

Urokinase-type plasminogen activator
type: ProteinReference
xref: PTHR24264:SF38
xref: uniprot P00749 170
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RYR1_2_3-RIGHT__RYR1_2_3-_re515
controller: cADPR

PARTICIPANT STOICHIOMETRY re175 867
type: Stoichiometry
physical entity: B-Raf
stoichiometric coefficient: 1.0

S45 beta catenin s932 sa321 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S45
feature location: S45 beta catenin s932 sa321 rs3 S45
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S45
comment: MODIFICATION_RESIDUE_ANGLE=3.845512436090568

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__PI3K_Class_I-_re101
controller: JAK2

PARTICIPANT STOICHIOMETRY re175 866
type: Stoichiometry
physical entity: RAF
stoichiometric coefficient: 1.0

RAF1
type: Protein
entity reference: RAF1
feature: Y341 RAF1 s156 sa686 rs2
feature: S497 9 RAF1 s156 sa686 rs8
feature: S621 RAF1 s156 sa686 rs9
feature: ACTIVE 13
feature: T268 9 RAF1 s156 sa686 rs7
feature: S338 RAF1 s156 sa686 rs1
feature: S259 RAF1 s156 sa686 rs3
feature: S43 RAF1 s156 sa686 rs6
feature: T491 RAF1 s156 sa686 rs4
feature: S494 RAF1 s156 sa686 rs5
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

uniprot P52564 174
type: UnificationXref
id: P52564
db: uniprot

Y418 SRC @Galphaq s719 sa95 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y418
feature location: Y418 SRC @Galphaq s719 sa95 rs3 Y418
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y418
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3192345766207003

S84 PPARgamma s1446 sa779 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S84
feature location: S84 PPARgamma s1446 sa779 rs1 S84
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7540866087105068
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S84

PARTICIPANT STOICHIOMETRY re57 711
type: Stoichiometry
physical entity: SHC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re57 712
type: Stoichiometry
physical entity: p66 SHC1
stoichiometric coefficient: 1.0

IKKbeta
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1813 sa259 466
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

p70S6K1
type: Protein
entity reference: p70S6K1
feature: T389 p70S6K1 s649 sa178 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CCK-83
type: Protein
entity reference: CCK-83
feature: ACTIVE 13
comment: SPECIES_TYPE=PROTEIN

TAC1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.TAC1
comment: ENTITY_REFERENCE_NOTES=

S876 PRKD2 s1820 sa695 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S876
feature location: S876 PRKD2 s1820 sa695 rs1 S876
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.583002134385839
comment: MODIFICATION_RESIDUE_NAME=S876
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

STATE_TRANSITION_LEFT__GAS_REBP2-RIGHT__GAS_REBP2-_re597
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re597 756
participant stoichiometry: PARTICIPANT STOICHIOMETRY re597 755
left: GAS-REBP2
interaction type: STATE_TRANSITION
right: GAS REBP2 s1639 sa917

uniprot P62873 78
type: UnificationXref
id: P62873
db: uniprot

S259 RAF1 s742 sa680 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S259
feature location: S259 RAF1 s742 sa680 rs3 S259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S259
comment: MODIFICATION_RESIDUE_ANGLE=2.328231397687482

Tyrosine-protein kinase CSK
type: ProteinReference
xref: uniprot P41240 97
xref: PTHR24418:SF407
organism: Homo sapiens

BAX
type: Complex
component stoichiometry: BAX s1567 sa967 STOICHIOMETRY ID COMPLEX
component: BAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s1567 sa967 376
cellular location: Mitochondria

MAPK1 3 s828 sa326 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re500 1119
type: Stoichiometry
physical entity: CCK-8
stoichiometric coefficient: 1.0

BAX
type: Complex
component stoichiometry: BAX s1558 sa853 STOICHIOMETRY ID COMPLEX
component: BAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s1558 sa853 256
cellular location: Mitochondria

PARTICIPANT STOICHIOMETRY re500 1118
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

BAX
type: Complex
component stoichiometry: BAX s1559 sa854 STOICHIOMETRY ID COMPLEX
component: BAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s1559 sa854 246
cellular location: Mitochondria

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot P53779 70
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re4 491
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Nuclear receptor subfamily 4 group A member 1
type: DnaReference
xref: PTHR24085:SF1
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re622 789
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 490
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PTHR24390:SF92
type: RelationshipXref
id: PTHR24390:SF92
db: PANTHER Family
relationship type: By Homology

Ryanodine receptor 2
type: ProteinReference
xref: PTHR13715:SF75
xref: uniprot Q92736 27
organism: Homo sapiens

mTORC2 complex
type: Complex
component stoichiometry: MAPKAP1 s962 sa319 STOICHIOMETRY ID COMPLEX
component stoichiometry: mLST8 s916 sa317 STOICHIOMETRY ID COMPLEX
component stoichiometry: mTOR s958 sa316 STOICHIOMETRY ID COMPLEX
component stoichiometry: RICTOR s960 sa318 STOICHIOMETRY ID COMPLEX
component: mLST8
component: RICTOR
component: MAPKAP1
component: mTOR
feature: COMPLEX BINDING FEATURE s956 csa28 313
feature: COMPLEX BINDING FEATURE s956 csa28 315
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s956 csa28 317
feature: COMPLEX BINDING FEATURE s956 csa28 311
cellular location: CELL

P07019
type: UnificationXref
id: P07019
db: PANTHER Pathway Component

FOXO3
type: Protein
entity reference: FOXO3
feature: T32 FOXO3 s1625 sa902 rs3
feature: S253 FOXO3 s1625 sa902 rs2
feature: S315 FOXO3 s1625 sa902 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re42 774
type: Stoichiometry
physical entity: Progastrin @ER - Golgi
stoichiometric coefficient: 1.0

Adenylate cyclase
type: Protein
entity reference: Adenylate cyclase
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CNKSR1
type: ProteinReference
xref: P07029
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CNKSR1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Connector enhancer of kinase suppressor of ras 1

AKT1
type: Protein
entity reference: AKT1
feature: COMPLEX PARTICIPANT BINDING FEATURE s905 sa305 330
feature: T308 AKT1 s905 sa305 rs1
feature: S473 AKT1 s905 sa305 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re622 790
type: Stoichiometry
physical entity: s1792
stoichiometric coefficient: 1.0

BAX
type: Complex
component stoichiometry: BAX s795 sa143 STOICHIOMETRY ID COMPLEX
component: BAX
feature: ACTIVE 13
cellular location: Mitochondria

PARTICIPANT STOICHIOMETRY re331 557
type: Stoichiometry
physical entity: Beta-arrestin-1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re331 558
type: Stoichiometry
physical entity: CCK2R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re331 559
type: Stoichiometry
physical entity: active CCK2R beta arrestin complex s1687 csa54
stoichiometric coefficient: 1.0

S621 RAF1 s1330 sa689 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S621
feature location: S621 RAF1 s1330 sa689 rs9 S621
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S621
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.46201537231871

PARTICIPANT STOICHIOMETRY re549 953
type: Stoichiometry
physical entity: AKAP
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q02750 17
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re549 954
type: Stoichiometry
physical entity: PKA Holoenzyme II
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NAD_PLUS_-RIGHT__cADPR-_re357
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re357 525
participant stoichiometry: PARTICIPANT STOICHIOMETRY re357 524
left: NAD+
interaction type: STATE_TRANSITION
right: cADPR

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HRAS_GDP-RIGHT__HRAS_GTP-_re523
controller: FAK2-SRC-GRB2 complex

PARTICIPANT STOICHIOMETRY re229 794
type: Stoichiometry
physical entity: PAI2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re564 888
type: Stoichiometry
physical entity: BAD/BCL2 heterodimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re229 793
type: Stoichiometry
physical entity: PAI2
stoichiometric coefficient: 1.0

T2446 mTOR s644 sa311 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T2446
feature location: T2446 mTOR s644 sa311 rs4 T2446
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T2446
comment: MODIFICATION_RESIDUE_ANGLE=2.3667132155949893

GalphaS s1185 sa492 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GalphaS
stoichiometric coefficient: 1.0

SP3
type: Protein
entity reference: SP3
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re42 773
type: Stoichiometry
physical entity: Preprogastrin @ER
stoichiometric coefficient: 1.0

beta catenin s932 sa321 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: beta catenin s932 sa321
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re468 1117
type: Stoichiometry
physical entity: CETP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PRKD1-RIGHT__PRKD1-_re27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 852
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 853
left: PRKD1
interaction type: STATE_TRANSITION
right: PRKD1

PARTICIPANT STOICHIOMETRY re468 1116
type: Stoichiometry
physical entity: CETP
stoichiometric coefficient: 1.0

E-cadherin/beta-catenin
type: Complex
component stoichiometry: beta catenin s932 sa321 STOICHIOMETRY ID COMPLEX
component stoichiometry: E cadherin s980 sa320 STOICHIOMETRY ID COMPLEX
component: beta catenin s932 sa321
component: E-cadherin
feature: COMPLEX BINDING FEATURE s1977 csa29 373
feature: COMPLEX BINDING FEATURE s1977 csa29 371
cellular location: CELL

IL8
type: ProteinReference
xref: P07136
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.IL8
member entity reference: Interleukin-8

PARTICIPANT STOICHIOMETRY re317 588
type: Stoichiometry
physical entity: FAK2-SRC complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re66 683
type: Stoichiometry
physical entity: Complex (GRB2/SOS1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re317 589
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

PRKD1
type: ProteinReference
xref: P07103
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PRKD1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Serine/threonine-protein kinase D1

NO
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__NFKB1_RelA_IKB_complex-RIGHT__NFKB1_RELA_IKB_complex-_re39
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 806
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 805
left: NFKB1-RelA-IKB complex
interaction type: STATE_TRANSITION
right: NFKB1-RELA-IKB complex

CCK1R s1485 sa456 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CCK1R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re317 590
type: Stoichiometry
physical entity: FAK2-SRC-GRB2 complex
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SRC_@Galphaq-RIGHT__SRC_@Galphaq-_re52
controller: PKCtheta

S21 FOS s1040 sa339 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S21
feature location: S21 FOS s1040 sa339 rs1 S21
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S21
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.348702615819714

FOS
type: RnaRegion
entity reference: FOS
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

Matrilysin
type: DnaReference
xref: PTHR10201:SF143
organism: Homo sapiens

S380 RSK1 2 s1856 sa215 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S380
feature location: S380 RSK1 2 s1856 sa215 rs4 S380
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=1.8133457596088143
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S380

STATE_TRANSITION_LEFT__MAPK1_3-RIGHT__MAPK1_3-_re620
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re620 795
participant stoichiometry: PARTICIPANT STOICHIOMETRY re620 796
left: MAPK1/3
interaction type: STATE_TRANSITION
right: MAPK1/3

RGS2
type: Protein
entity reference: RGS2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PKCeta
type: Protein
entity reference: PKCeta
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S/T kinase(s)
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=UNKNOWN

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q05655 79
xref: PTHR24356:SF365
organism: Homo sapiens

Matrix metalloproteinase-9
type: DnaReference
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re66 685
type: Stoichiometry
physical entity: SHC1-GRB2-SOS1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re66 684
type: Stoichiometry
physical entity: SHC1 @EGFR
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Anti-apoptosis
controller: BIRC3

PARTICIPANT STOICHIOMETRY re564 889
type: Stoichiometry
physical entity: BAD/BCL2 heterodimer
stoichiometric coefficient: 1.0

beta-catenin
type: Protein
entity reference: beta-catenin
feature: T41 beta catenin s1273 sa637 rs4
feature: S37 beta catenin s1273 sa637 rs1
feature: S45 beta catenin s1273 sa637 rs3
feature: S33 beta catenin s1273 sa637 rs2
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re352 535
type: Stoichiometry
physical entity: GMP
stoichiometric coefficient: 1.0

Adenylate cyclase
type: Protein
entity reference: Adenylate cyclase
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

uniprot P04049 96
type: UnificationXref
id: P04049
db: uniprot

PARTICIPANT STOICHIOMETRY re352 536
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

Rho GTPase-activating protein 4
type: ProteinReference
xref: PTHR14166:SF16
xref: uniprot P98171 54
organism: Homo sapiens

CLU
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.CLU
comment: ENTITY_REFERENCE_NOTES=

p66 SHC1
type: ProteinReference
xref: P07168
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p66 SHC1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: SHC-transforming protein 1

PARTICIPANT STOICHIOMETRY re656 668
type: Stoichiometry
physical entity: CCK1R
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__JUN-RIGHT__JUN-_re463
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re463 1134
participant stoichiometry: PARTICIPANT STOICHIOMETRY re463 1133
left: JUN
interaction type: KNOWN_TRANSITION_OMITTED
right: JUN

PARTICIPANT STOICHIOMETRY re656 667
type: Stoichiometry
physical entity: CCK1R (active)
stoichiometric coefficient: 1.0

Pre-pro CCK @ ER
type: ProteinReference
xref: P07128
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Pre-pro CCK @ ER
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

KNOWN_TRANSITION_OMITTED_LEFT__FOS-RIGHT__FOS-_re540
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re540 973
participant stoichiometry: PARTICIPANT STOICHIOMETRY re540 974
left: FOS
interaction type: KNOWN_TRANSITION_OMITTED
right: FOS

PARTICIPANT STOICHIOMETRY re63 696
type: Stoichiometry
physical entity: SHC1 @EGFR
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__CCK1R__active_-RIGHT__CCK_CCK1R-_re283
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re283 584
participant stoichiometry: PARTICIPANT STOICHIOMETRY re283 583
left: CCK1R (active)
interaction type: TRANSPORT
right: CCK-CCK1R

PARTICIPANT STOICHIOMETRY re63 695
type: Stoichiometry
physical entity: SHC1
stoichiometric coefficient: 1.0

MAPK1/3
type: Protein
entity reference: MAPK1/3
feature: ACTIVE 13
feature: T202 MAPK1 3 s828 sa326 rs3
feature: Y204 MAPK1 3 s828 sa326 rs4

HOMODIMER ID 92STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 2.0

PTHR45634:SF9
type: RelationshipXref
id: PTHR45634:SF9
db: PANTHER Family
relationship type: By Homology

FAK2
type: Protein
entity reference: FAK2
feature: Y402 FAK2 s1203 sa519 rs1
feature: Y579 FAK2 s1203 sa519 rs2
feature: Y881 FAK2 s1203 sa519 rs4
feature: Y580 FAK2 s1203 sa519 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__ATF2-RIGHT__ATF2-_re460
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re460 1145
participant stoichiometry: PARTICIPANT STOICHIOMETRY re460 1144
left: ATF2
interaction type: STATE_TRANSITION
right: ATF2

STATE_TRANSITION_LEFT__ATF2-RIGHT__ATF2-_re461
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re461 1140
participant stoichiometry: PARTICIPANT STOICHIOMETRY re461 1139
left: ATF2
interaction type: STATE_TRANSITION
right: ATF2

S154 CCK2R s1410 sa568 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S154
feature location: S154 CCK2R s1410 sa568 rs3 S154
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.234636338452209
comment: MODIFICATION_RESIDUE_NAME=S154

S749 RSK1 2 s546 sa329 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S749
feature location: S749 RSK1 2 s546 sa329 rs6 S749
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=S749
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.408013221559381

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RHEB_GDP-RIGHT__RHEB_GTP-_re113
controller: GEF

IkB kinase complex
type: Complex
component stoichiometry: IKKgamma s1812 sa258 STOICHIOMETRY ID COMPLEX
component stoichiometry: IKKbeta s1813 sa259 STOICHIOMETRY ID COMPLEX
component stoichiometry: IKKalpha s1814 sa260 STOICHIOMETRY ID COMPLEX
component: IKKbeta
component: IKKgamma
component: IKKalpha s1814 sa260
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s1811 csa4 467
feature: COMPLEX BINDING FEATURE s1811 csa4 463
feature: COMPLEX BINDING FEATURE s1811 csa4 465
cellular location: CELL

PTHR22968:SF9
type: RelationshipXref
id: PTHR22968:SF9
db: PANTHER Family
relationship type: By Homology

Y705 STAT3 s676 sa323 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y705
feature location: Y705 STAT3 s676 sa323 rs1 Y705
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.71
comment: MODIFICATION_RESIDUE_NAME=Y705

PARTICIPANT STOICHIOMETRY re356 526
type: Stoichiometry
physical entity: CD38
stoichiometric coefficient: 1.0

ITGAV
type: ProteinReference
xref: P07133
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.ITGAV
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Integrin alpha-V

PARTICIPANT STOICHIOMETRY re356 527
type: Stoichiometry
physical entity: CD38
stoichiometric coefficient: 1.0

PTHR16915:SF0
type: RelationshipXref
id: PTHR16915:SF0
db: PANTHER Family
relationship type: By Homology

GSK3beta
type: Protein
entity reference: GSK3 beta PROTEIN
feature: S9 GSK3beta s935 sa199 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Regulator of G-protein signaling 2
type: ProteinReference
xref: uniprot P41220 85
xref: PTHR10845:SF43
organism: Homo sapiens

ICER
type: Protein
entity reference: ICER
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MAP2K5-RIGHT__MAP2K5-_re162
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re162 927
participant stoichiometry: PARTICIPANT STOICHIOMETRY re162 926
left: MAP2K5
interaction type: STATE_TRANSITION
right: MAP2K5

go GO:0005634 4
type: UnificationXref
id: GO:0005634
db: go

uniprot P18146 82
type: UnificationXref
id: P18146
db: uniprot

IkB kinase complex
type: Complex
component stoichiometry: IKKgamma s1812 sa261 STOICHIOMETRY ID COMPLEX
component stoichiometry: IKKalpha s1814 sa263 STOICHIOMETRY ID COMPLEX
component stoichiometry: IKKbeta s1813 sa262 STOICHIOMETRY ID COMPLEX
component: IKKalpha
component: IKKgamma
component: IKKbeta
feature: COMPLEX BINDING FEATURE s1811 csa5 473
feature: COMPLEX BINDING FEATURE s1811 csa5 469
feature: COMPLEX BINDING FEATURE s1811 csa5 471
cellular location: CELL

PPARgamma
type: ProteinReference
xref: P07060
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PPAR_gamma_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Peroxisome proliferator-activated receptor gamma

FAK2
type: ProteinReference
xref: P07218
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.FAK2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein-tyrosine kinase 2-beta

PARTICIPANT STOICHIOMETRY re51 728
type: Stoichiometry
physical entity: MMP3
stoichiometric coefficient: 1.0

Y204 MAPK1 3 s1788 sa954 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y204
feature location: Y204 MAPK1 3 s1788 sa954 rs4 Y204
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.500664060131579
comment: MODIFICATION_RESIDUE_NAME=Y204

PARTICIPANT STOICHIOMETRY re51 727
type: Stoichiometry
physical entity: MMP3
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__SRC_@Galphaq-RIGHT__Complex__HBEGF_EGFR_-_re62
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re62 697
participant stoichiometry: PARTICIPANT STOICHIOMETRY re62 698
left: SRC @Galphaq
interaction type: KNOWN_TRANSITION_OMITTED
right: Complex (HBEGF/EGFR)

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

uniprot Q99558 62
type: UnificationXref
id: Q99558
db: uniprot

PTHR48013:SF9
type: RelationshipXref
id: PTHR48013:SF9
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re433 1180
type: Stoichiometry
physical entity: HuR-COX2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re433 1181
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

PAI2
type: RnaRegion
entity reference: PAI2
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

IKKalpha s1814 sa263 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IKKalpha
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: PTHR13809:SF25
xref: uniprot P59768 77
organism: Homo sapiens

Y577 FAK1 s669 sa111 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y577
feature location: Y577 FAK1 s669 sa111 rs4 Y577
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.29
comment: MODIFICATION_RESIDUE_NAME=Y577

PARTICIPANT STOICHIOMETRY re283 583
type: Stoichiometry
physical entity: CCK1R (active)
stoichiometric coefficient: 1.0

GRB2 s949 sa283 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

ICER
type: Protein
entity reference: ICER
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

T32 FOXO3 s1621 sa901 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T32
feature location: T32 FOXO3 s1621 sa901 rs3 T32
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.792898447626701
comment: MODIFICATION_RESIDUE_NAME=T32

PARTICIPANT STOICHIOMETRY re283 584
type: Stoichiometry
physical entity: CCK-CCK1R
stoichiometric coefficient: 1.0

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

S43 RAF1 s742 sa680 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S43
feature location: S43 RAF1 s742 sa680 rs6 S43
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.908388522052502
comment: MODIFICATION_RESIDUE_NAME=S43

GAS-REBP1
type: Protein
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

CSK
type: Protein
entity reference: CSK
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

GRB2 @EGFR s893 sa269 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GRB2 @EGFR
stoichiometric coefficient: 1.0

PRKD2
type: Protein
entity reference: PRKD2
feature: S710 PRKD2 s774 sa735 rs3
feature: S706 PRKD2 s774 sa735 rs2
feature: S876 PRKD2 s774 sa735 rs1
feature: S244 PRKD2 s774 sa735 rs6
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re45 772
type: Stoichiometry
physical entity: G17
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re45 771
type: Stoichiometry
physical entity: G34
stoichiometric coefficient: 1.0

T268 9 RAF1 s154 sa685 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T268 9
feature location: T268 9 RAF1 s154 sa685 rs7 T268 9
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T268/9
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PAK1
type: ProteinReference
xref: P07065
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PAK1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Serine/threonine-protein kinase PAK 1

PARTICIPANT STOICHIOMETRY re21 869
type: Stoichiometry
physical entity: Novel PKC
stoichiometric coefficient: 1.0

Y705 STAT3 s674 sa181 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y705
feature location: Y705 STAT3 s674 sa181 rs1 Y705
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.71
comment: MODIFICATION_RESIDUE_NAME=Y705

uniprot Q15139 152
type: UnificationXref
id: Q15139
db: uniprot

PARTICIPANT STOICHIOMETRY re21 868
type: Stoichiometry
physical entity: Novel PKC
stoichiometric coefficient: 1.0

uniprot Q15413 26
type: UnificationXref
id: Q15413
db: uniprot

S307 CCK1R s1672 sa775 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S307
feature location: S307 CCK1R s1672 sa775 rs3 S307
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.912135572113799
comment: MODIFICATION_RESIDUE_NAME=S307

S319 FOXO1 s1990 sa994 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S319
feature location: S319 FOXO1 s1990 sa994 rs2 S319
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7484716674691777
comment: MODIFICATION_RESIDUE_NAME=S319

S710 PRKD2 s1388 sa736 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S710
feature location: S710 PRKD2 s1388 sa736 rs3 S710
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3074279375630917
comment: MODIFICATION_RESIDUE_NAME=S710

ATF2 s1051 sa350 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 1.0

T24 FOXO1 s1620 sa899 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T24
feature location: T24 FOXO1 s1620 sa899 rs3 T24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.79
comment: MODIFICATION_RESIDUE_NAME=T24

SHC1-GRB2-SOS1
type: Complex
component stoichiometry: SHC1 @EGFR s892 sa268 STOICHIOMETRY ID COMPLEX
component stoichiometry: GRB2 @EGFR s893 sa269 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS1 s894 sa270 STOICHIOMETRY ID COMPLEX
component: SOS1
component: GRB2 @EGFR
component: SHC1 @EGFR
feature: COMPLEX BINDING FEATURE s1922 csa8 343
feature: COMPLEX BINDING FEATURE s1922 csa8 339
feature: COMPLEX BINDING FEATURE s1922 csa8 341
cellular location: CELL

PTHR10044:SF79
type: RelationshipXref
id: PTHR10044:SF79
db: PANTHER Family
relationship type: By Homology

uPA
type: DnaRegion
entity reference: uPA
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Apoptosis regulator Bcl-2
type: ProteinReference
xref: uniprot P10415 42
xref: PTHR11256:SF11
organism: Homo sapiens

Caffeine
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=DRUG

Y332 CAS s765 sa116 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y332
feature location: Y332 CAS s765 sa116 rs3 Y332
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y332
comment: MODIFICATION_RESIDUE_ANGLE=3.809181092477624

RYR1/2/3
type: ProteinReference
xref: P07088
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RYR1/2/3
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ryanodine receptor 1
member entity reference: Ryanodine receptor 3
member entity reference: Ryanodine receptor 2

MAPK3
type: Protein
entity reference: MAPK3
feature: Y204 MAPK3 s989 sa208 rs2
feature: T202 MAPK3 s989 sa208 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y94 Pro CCK @ TGN s1191 sa499 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 Pro CCK @ TGN s1191 sa499 rs3 Y94
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.512520442662609
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y94

Progastrin @Golgi
type: Protein
feature: Y Progastrin @Golgi s1403 sa772 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot P07948 165
type: UnificationXref
id: P07948
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GAS_REBP1-RIGHT__GAS_REBP1-_re596
controller: AP1 (FOS+JUN)

BIRC3
type: DnaRegion
entity reference: BIRC3
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Two pore calcium channel protein 2
type: ProteinReference
xref: uniprot Q8NHX9 52
xref: PTHR46768:SF1
organism: Homo sapiens

T SOS1 s890 sa281 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T SOS1 s890 sa281 rs1 T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_ANGLE=0.8611146530060259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

Y31 Paxillin s671 sa114 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y31
feature location: Y31 Paxillin s671 sa114 rs1 Y31
comment: MODIFICATION_RESIDUE_ANGLE=0.79
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y31

PARTICIPANT STOICHIOMETRY re669 610
type: Stoichiometry
physical entity: NFAT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re669 611
type: Stoichiometry
physical entity: NFAT1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK1_3-RIGHT__MAPK1_3-_re620
controller: MKP

S434 CCK2R s1410 sa568 rs12
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S434
feature location: S434 CCK2R s1410 sa568 rs12 S434
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.078526462630984
comment: MODIFICATION_RESIDUE_NAME=S434

BCL2L1
type: ProteinReference
xref: P07117
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.BCL2L1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Bcl-2-like protein 1

PTHR12844:SF10
type: RelationshipXref
id: PTHR12844:SF10
db: PANTHER Family
relationship type: By Homology

CaMKIV s2009 sa1007 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.774879437994804
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Connector enhancer of kinase suppressor of ras 1
type: ProteinReference
xref: uniprot Q969H4 33
xref: PTHR12844:SF10
organism: Homo sapiens

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__COX2-RIGHT__COX2-_re425
controller: MEF2

RPTOR
type: Protein
feature: S719 RPTOR s643 sa312 rs1
feature: S721 RPTOR s643 sa312 rs2
feature: S722 RPTOR s643 sa312 rs3
feature: COMPLEX PARTICIPANT BINDING FEATURE s643 sa312 176
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re118 1087
type: Stoichiometry
physical entity: 4E-BP1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re118 1088
type: Stoichiometry
physical entity: EIF4E
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re118 1086
type: Stoichiometry
physical entity: 4E-BP1/EIF4E complex
stoichiometric coefficient: 1.0

Y416 SRC @Galphaq s1894 sa976 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 SRC @Galphaq s1894 sa976 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789

AKT1
type: ProteinReference
xref: P07152
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.AKT1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: RAC-alpha serine/threonine-protein kinase

MAP2K2
type: Protein
entity reference: MAP2K2
feature: ACTIVE 13
feature: S222 MAP2K2 s824 sa205 rs1
feature: S218 MAP2K2 s824 sa205 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

T573 RSK1 2 s537 sa211 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T573
feature location: T573 RSK1 2 s537 sa211 rs3 T573
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=T573

S319 FOXO1 s1620 sa899 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S319
feature location: S319 FOXO1 s1620 sa899 rs2 S319
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7484716674691777
comment: MODIFICATION_RESIDUE_NAME=S319

FAK1
type: Protein
entity reference: FAK1
feature: Y397 FAK1 s669 sa111 rs1
feature: Y861 FAK1 s669 sa111 rs5
feature: Y576 FAK1 s669 sa111 rs3
feature: Y407 FAK1 s669 sa111 rs2
feature: Y925 FAK1 s669 sa111 rs6
feature: Y577 FAK1 s669 sa111 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PDPK1-RIGHT__PDPK1-_re105
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re105 1129
participant stoichiometry: PARTICIPANT STOICHIOMETRY re105 1130
left: PDPK1
interaction type: STATE_TRANSITION
right: PDPK1

CaM
type: Protein
entity reference: CaM
feature: COMPLEX PARTICIPANT BINDING FEATURE s2012 sa1009 420
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK2-RIGHT__FAK2-_re312
controller: Ca2+

S221 RSK1 2 s537 sa211 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 RSK1 2 s537 sa211 rs5 S221
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=3.8909266156067464
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221

Y317 SHC1 @EGFR s882 sa108 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y317
feature location: Y317 SHC1 @EGFR s882 sa108 rs1 Y317
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7472271186373366
comment: MODIFICATION_RESIDUE_NAME=Y317

Y881 FAK2 s1591 sa878 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y881
feature location: Y881 FAK2 s1591 sa878 rs4 Y881
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5
comment: MODIFICATION_RESIDUE_NAME=Y881

S37 beta catenin s1273 sa637 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S37
feature location: S37 beta catenin s1273 sa637 rs1 S37
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S37

SHC1
type: ProteinReference
xref: P07138
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.SHC1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: SHC-transforming protein 1

PTHR11256:SF42
type: RelationshipXref
id: PTHR11256:SF42
db: PANTHER Family
relationship type: By Homology

PTHR11256:SF46
type: RelationshipXref
id: PTHR11256:SF46
db: PANTHER Family
relationship type: By Homology

BCL2L1 s1773 sa896 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BCL2L1
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__PLA2-RIGHT__PLA2-_re543
control type: ACTIVATION
controller: Gbeta

VMAT2
type: RnaRegion
entity reference: VMAT2
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

Y966 JAK2 s1634 sa152 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y966
feature location: Y966 JAK2 s1634 sa152 rs2 Y966
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y966
comment: MODIFICATION_RESIDUE_ANGLE=5.53026601520083

STATE_TRANSITION_LEFT__EGR1-RIGHT__EGR1-_re629
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re629 782
participant stoichiometry: PARTICIPANT STOICHIOMETRY re629 781
left: EGR1
interaction type: STATE_TRANSITION
right: EGR1

Pro-CCK @ secretory granule
type: ProteinReference
xref: P07206
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Pro-CCK_br_@ secretory granule
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

T32 FOXO3 s1625 sa902 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T32
feature location: T32 FOXO3 s1625 sa902 rs3 T32
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.792898447626701
comment: MODIFICATION_RESIDUE_NAME=T32

STATE_TRANSITION_LEFT__RPS6-RIGHT__RPS6-_re117
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re117 1090
participant stoichiometry: PARTICIPANT STOICHIOMETRY re117 1089
left: RPS6
interaction type: STATE_TRANSITION
right: RPS6

STAT3 s676 sa323 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 2.0

E-cadherin
type: Protein
entity reference: E-cadherin
feature: COMPLEX PARTICIPANT BINDING FEATURE s980 sa320 372
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PKA-R1alpha/beta
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1531 sa837 476
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

GRB2 s1607 sa888 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

PTHR45851:SF1
type: RelationshipXref
id: PTHR45851:SF1
db: PANTHER Family
relationship type: By Homology

Y407 FAK1 s668 sa118 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y407
feature location: Y407 FAK1 s668 sa118 rs2 Y407
comment: MODIFICATION_RESIDUE_NAME=Y407
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.74

TRIGGER
type: RelationshipTypeVocabulary

CaN
type: ProteinReference
xref: P07178
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CaN
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__GCG-RIGHT__GCG-_re466
controller: EGR1

uniprot P28907 32
type: UnificationXref
id: P28907
db: uniprot

uniprot Q07889 110
type: UnificationXref
id: Q07889
db: uniprot

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__HDC-RIGHT__HDC-_re437
controller: GAS-REBP3

PARTICIPANT STOICHIOMETRY re438 1176
type: Stoichiometry
physical entity: HDC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re438 1177
type: Stoichiometry
physical entity: HDC
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEF2-RIGHT__MEF2-_re631
controller: p38MAPK s998 sa227

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__PI3K_Class_I-_re101
control type: INHIBITION
controller: Wortmannin

STATE_TRANSITION_LEFT__RAC1_GTP-RIGHT__Pi-_RAC1_GDP-_re77
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re77 646
participant stoichiometry: PARTICIPANT STOICHIOMETRY re77 648
participant stoichiometry: PARTICIPANT STOICHIOMETRY re77 647
left: RAC1-GTP
interaction type: STATE_TRANSITION
right: RAC1-GDP
right: Pi

T440 CCK2R s1410 sa568 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T440
feature location: T440 CCK2R s1410 sa568 rs8 T440
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.06610690323832
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T440

Beta arrestin 1 2 s1412 sa570 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-arrestin-1/2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CaMKIV-RIGHT__CaMKIV-_re666
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re666 620
participant stoichiometry: PARTICIPANT STOICHIOMETRY re666 619
left: CaMKIV
interaction type: STATE_TRANSITION
right: CaMKIV

Ggamma
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1371 sa697 210
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re101 1143
type: Stoichiometry
physical entity: PI3K Class I
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re101 1142
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__CCK_83-RIGHT__CCK-_re489
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re489 1050
participant stoichiometry: PARTICIPANT STOICHIOMETRY re489 1049
left: CCK-83
interaction type: KNOWN_TRANSITION_OMITTED
right: CCK

PARTICIPANT STOICHIOMETRY re101 1141
type: Stoichiometry
physical entity: p85
stoichiometric coefficient: 1.0

T359 RSK1 2 s546 sa329 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T359
feature location: T359 RSK1 2 s546 sa329 rs2 T359
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=T359
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7908334448050431

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__COX2-RIGHT__COX2-_re425
controller: AP1 (FOS+JUN)

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P24723 163
organism: Homo sapiens

HDC
type: RnaRegion
entity reference: HDC
cellular location: CELL
comment: SPECIES_TYPE=RNA

PI3,4,5-P3
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s912 sa304 328
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TACR1
type: RnaRegion
entity reference: TACR1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

uniprot P19174 103
type: UnificationXref
id: P19174
db: uniprot

BCL2L1
type: Protein
entity reference: BCL2L1
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__E_cadherin_beta_catenin-RIGHT__E_cadherin-_beta_catenin-_re362
controller: PAK1

PARTICIPANT STOICHIOMETRY re357 525
type: Stoichiometry
physical entity: cADPR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re357 524
type: Stoichiometry
physical entity: NAD+
stoichiometric coefficient: 1.0

CaM
type: ProteinReference
xref: P07193
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CaM
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Calmodulin-1

STATE_TRANSITION_LEFT__GAS_REBP3-RIGHT__GAS_REBP3-_re598
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re598 754
participant stoichiometry: PARTICIPANT STOICHIOMETRY re598 753
left: GAS-REBP3
interaction type: STATE_TRANSITION
right: GAS-REBP3

Y317 p46 SHC1 s947 sa279 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y317
feature location: Y317 p46 SHC1 s947 sa279 rs1 Y317
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7243274201314622
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y317

PTHR10044:SF99
type: RelationshipXref
id: PTHR10044:SF99
db: PANTHER Family
relationship type: By Homology

uniprot Q9Y4K3 20
type: UnificationXref
id: Q9Y4K3
db: uniprot

Y239 240 p46 SHC1 s722 sa100 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y239 240
feature location: Y239 240 p46 SHC1 s722 sa100 rs2 Y239 240
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y239/240
comment: MODIFICATION_RESIDUE_ANGLE=2.3695516018147504

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot P42574 50
organism: Homo sapiens

STATE_TRANSITION_LEFT__PDPK1-RIGHT__PDPK1-_re147
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re147 978
participant stoichiometry: PARTICIPANT STOICHIOMETRY re147 977
left: PDPK1
interaction type: STATE_TRANSITION
right: PDPK1

S319 FOXO1 s1624 sa900 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S319
feature location: S319 FOXO1 s1624 sa900 rs2 S319
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7484716674691777
comment: MODIFICATION_RESIDUE_NAME=S319

PARTICIPANT STOICHIOMETRY re467 1120
type: Stoichiometry
physical entity: ACAT1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKCalpha-RIGHT__PKCalpha-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 489
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 488
left: PKCalpha
interaction type: STATE_TRANSITION
right: PKCalpha

S338 RAF1 s742 sa680 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S338
feature location: S338 RAF1 s742 sa680 rs1 S338
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S338
comment: MODIFICATION_RESIDUE_ANGLE=1.5707963267948966

p70S6K1
type: ProteinReference
xref: P07031
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p70S6K1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ribosomal protein S6 kinase beta-1

TRANSCRIPTION_LEFT__CXCL2-RIGHT__CXCL2-_re505
type: TemplateReaction
product: CXCL2
xref: TRANSCRIPTION
participant: CXCL2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__NFKB_RELA_heterodimer-RIGHT__NFKB1_RELA_heterodimer-_re529
controller: MAPK8-10

S222 MAP2K1 s822 sa204 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S222
feature location: S222 MAP2K1 s822 sa204 rs2 S222
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7629582158718069
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S222

PARTICIPANT STOICHIOMETRY re467 1121
type: Stoichiometry
physical entity: ACAT1
stoichiometric coefficient: 1.0

T222 MAPKAP K2 s1583 sa870 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T222
feature location: T222 MAPKAP K2 s1583 sa870 rs1 T222
comment: MODIFICATION_RESIDUE_NAME=T222
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8539933973255165

NFAT1
type: Protein
entity reference: NFAT1
feature: S NFAT1 s2016 sa1012 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y91 CCK G s1194 sa503 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y91
feature location: Y91 CCK G s1194 sa503 rs2 Y91
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_NAME=Y91
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7853981633974483

Transcription factor Sp1
type: ProteinReference
xref: uniprot P08047 118
xref: PTHR23235:SF16
organism: Homo sapiens

ROCK1
type: Protein
entity reference: ROCK1
feature: T ROCK1 s787 sa138 rs2
feature: ACTIVE 13
feature: S ROCK1 s787 sa138 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y239 240 p52 SHC1 s711 sa104 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y239 240
feature location: Y239 240 p52 SHC1 s711 sa104 rs2 Y239 240
comment: MODIFICATION_RESIDUE_ANGLE=2.361294478266354
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y239/240

CCK
type: ProteinReference
xref: P07077
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CCK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__LYN-RIGHT__LYN-_re637
controller: Conventional PKC

IKBalpha
type: Protein
entity reference: IKBalpha
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s1210 sa255 310
feature: S36 IKBalpha s1210 sa255 rs2
feature: S32 IKBalpha s1210 sa255 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

SOS1 s749 sa276 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS1
stoichiometric coefficient: 1.0

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__FOS-RIGHT__FOS-_re206
control type: INHIBITION
controller: ICER

S32 IKBalpha s844 sa252 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S32
feature location: S32 IKBalpha s844 sa252 rs1 S32
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S32
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7

KNOWN_TRANSITION_OMITTED_LEFT__MEF2B-RIGHT__MEF2-_re203
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re203 896
participant stoichiometry: PARTICIPANT STOICHIOMETRY re203 897
left: MEF2B
interaction type: KNOWN_TRANSITION_OMITTED
right: MEF2

Y182 p38MAPK s144 sa225 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y182
feature location: Y182 p38MAPK s144 sa225 rs1 Y182
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y182
comment: MODIFICATION_RESIDUE_ANGLE=0.84

PTHR48013:SF12
type: RelationshipXref
id: PTHR48013:SF12
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRKD1-RIGHT__PRKD1-_re27
controller: PKCepsilon

PARTICIPANT STOICHIOMETRY re151 950
type: Stoichiometry
physical entity: MAP2K6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re578 842
type: Stoichiometry
physical entity: BAD/BCL2L1 heterodimer
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CREB1-RIGHT__CREB1-_re188
controller: RSK1/2

S706 PRKD2 s773 sa696 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S706
feature location: S706 PRKD2 s773 sa696 rs2 S706
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S706
comment: MODIFICATION_RESIDUE_ANGLE=0.8559137879749282

T491 RAF1 s1721 sa694 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T491
feature location: T491 RAF1 s1721 sa694 rs4 T491
comment: MODIFICATION_RESIDUE_NAME=T491
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.3986264000533355

S37 beta catenin s1315 sa638 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S37
feature location: S37 beta catenin s1315 sa638 rs1 S37
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S37

BAX
type: Protein
entity reference: BAX

S494 RAF1 s155 sa679 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S494
feature location: S494 RAF1 s155 sa679 rs5 S494
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.018263774283071
comment: MODIFICATION_RESIDUE_NAME=S494

FAK1
type: Protein
entity reference: FAK1
feature: COMPLEX PARTICIPANT BINDING FEATURE s776 sa285 368
feature: Y925 FAK1 s776 sa285 rs6
feature: ACTIVE 13
feature: Y407 FAK1 s776 sa285 rs2
feature: Y861 FAK1 s776 sa285 rs5
feature: Y577 FAK1 s776 sa285 rs4
feature: Y397 FAK1 s776 sa285 rs1
feature: Y576 FAK1 s776 sa285 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Casein kinase I isoform epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot P49674 76
organism: Homo sapiens

Y221 MAPK7 s471 sa232 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y221
feature location: Y221 MAPK7 s471 sa232 rs2 Y221
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=Y221
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_TYPE=residue

PTHR48013:SF20
type: RelationshipXref
id: PTHR48013:SF20
db: PANTHER Family
relationship type: By Homology

uPA
type: RnaRegion
entity reference: uPA
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

uniprot Q8N1W1 39
type: UnificationXref
id: Q8N1W1
db: uniprot

IKKbeta s1813 sa262 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IKKbeta
stoichiometric coefficient: 1.0

Y239 240 p52 SHC1 s899 sa274 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y239 240
feature location: Y239 240 p52 SHC1 s899 sa274 rs2 Y239 240
comment: MODIFICATION_RESIDUE_ANGLE=2.361294478266354
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y239/240

PARTICIPANT STOICHIOMETRY re524 1045
type: Stoichiometry
physical entity: SHC
stoichiometric coefficient: 1.0

PTHR11999:SF68
type: RelationshipXref
id: PTHR11999:SF68
db: PANTHER Family
relationship type: By Homology

PTHR10131:SF131
type: RelationshipXref
id: PTHR10131:SF131
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re524 1046
type: Stoichiometry
physical entity: SHC1
stoichiometric coefficient: 1.0

CXCL1
type: DnaRegionReference
member entity reference: Growth-regulated alpha protein
xref: G07268
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.CXCL1
comment: ENTITY_REFERENCE_NOTES=

SHP-2
type: Protein
entity reference: SHP-2
feature: ACTIVE 13
feature: Y580 SHP 2 s1444 sa629 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PI3,4,5-P3
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1765 sa300 336
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Y925 FAK1 s1450 sa782 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y925
feature location: Y925 FAK1 s1450 sa782 rs6 Y925
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.95
comment: MODIFICATION_RESIDUE_NAME=Y925

CCK s1911 sa947 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CCK s1911 sa947
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re518 1077
type: Stoichiometry
physical entity: c-RAF/14-3-3 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re518 1076
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

Ryanodine receptor 1
type: ProteinReference
xref: uniprot P21817 25
xref: PTHR13715:SF15
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re518 1075
type: Stoichiometry
physical entity: 14-3-3 beta/alpha
stoichiometric coefficient: 1.0

RHEB-GTP
type: ProteinReference
xref: P07224
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RHEB-GTP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: GTP-binding protein Rheb

p46 SHC1
type: Protein
entity reference: p46 SHC1
feature: Y239 240 p46 SHC1 s1781 sa103 rs2
feature: Y317 p46 SHC1 s1781 sa103 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Migration
controller: MMP9

NFKB1 p50 s1747 sa264 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NFKB1 (p50)
stoichiometric coefficient: 1.0

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__CHGA-RIGHT__CHGA-_re232
controller: CREB1

PARTICIPANT STOICHIOMETRY re453 1151
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re453 1150
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re365
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re365 512
participant stoichiometry: PARTICIPANT STOICHIOMETRY re365 511
left: beta-catenin
interaction type: STATE_TRANSITION
right: beta-catenin

PKA Holoenzyme I
type: Complex
component stoichiometry: PKA R1alpha beta s1519 sa829 STOICHIOMETRY ID COMPLEX
component stoichiometry: PKA Calpha beta gamma s1523 sa831 STOICHIOMETRY ID COMPLEX
component: PKA-R1alpha/beta
component: PKA-Calpha/beta/gamma
feature: COMPLEX BINDING FEATURE s1955 csa65 319
feature: COMPLEX BINDING FEATURE s1955 csa65 321
cellular location: CELL

STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re364
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re364 513
participant stoichiometry: PARTICIPANT STOICHIOMETRY re364 514
left: beta-catenin
interaction type: STATE_TRANSITION
right: beta-catenin

PARTICIPANT STOICHIOMETRY re578 841
type: Stoichiometry
physical entity: BAD/BCL2L1 heterodimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re405 503
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

S241 PDPK1 s902 sa306 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S241
feature location: S241 PDPK1 s902 sa306 rs1 S241
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=0.7668909901804244
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S241

PARTICIPANT STOICHIOMETRY re335 550
type: Stoichiometry
physical entity: s21
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Migration
controller: JAK2

PARTICIPANT STOICHIOMETRY re405 504
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

HuR-IL8
type: Complex
component stoichiometry: IL8 s1079 sa732 STOICHIOMETRY ID COMPLEX
component stoichiometry: HuR s1073 sa731 STOICHIOMETRY ID COMPLEX
component: HuR
component: IL8
feature: COMPLEX BINDING FEATURE s1984 csa62 405
feature: COMPLEX BINDING FEATURE s1984 csa62 407
cellular location: CELL

Galpha13beta/gamma
type: Complex
component stoichiometry: Galpha13 s135 sa577 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s136 sa578 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta gamma s91 sa576 STOICHIOMETRY ID COMPLEX
component: GDP
component: Gbeta/gamma
component: Galpha13
feature: COMPLEX BINDING FEATURE s2022 csa57 191
feature: COMPLEX BINDING FEATURE s2022 csa57 193
feature: COMPLEX BINDING FEATURE s2022 csa57 195
cellular location: CELL

PKCbeta
type: Protein
entity reference: PKCbeta
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re335 549
type: Stoichiometry
physical entity: G17
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re151 949
type: Stoichiometry
physical entity: MAP2K6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re667 616
type: Stoichiometry
physical entity: Ca_CaM
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re667 617
type: Stoichiometry
physical entity: CaN
stoichiometric coefficient: 1.0

CCND1
type: RnaRegion
entity reference: CCND1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__TAC1-RIGHT__TAC1-_re508
controller: NFKB1/RELA heterodimer

Ornithine decarboxylase
type: ProteinReference
xref: uniprot P11926 71
xref: PTHR11482:SF42
organism: Homo sapiens

T ROCK1 s787 sa138 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T ROCK1 s787 sa138 rs2 T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7629582158718069
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PARTICIPANT STOICHIOMETRY re667 618
type: Stoichiometry
physical entity: Ca_CaM
stoichiometric coefficient: 1.0

S621 RAF1 s156 sa686 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S621
feature location: S621 RAF1 s156 sa686 rs9 S621
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S621
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.46201537231871

NFKB1 (p50)
type: Protein
feature: NFKB1 p50 s1681 sa327 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1681 sa327 284
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

Carboxypeptidase E
type: Protein
entity reference: Carboxypeptidase E
comment: SPECIES_TYPE=PROTEIN

uniprot P27361 139
type: UnificationXref
id: P27361
db: uniprot

ITGAV
type: DnaRegion
entity reference: ITGAV
cellular location: CELL
comment: SPECIES_TYPE=GENE

PTHR11792:SF20
type: RelationshipXref
id: PTHR11792:SF20
db: PANTHER Family
relationship type: By Homology

PTHR11256:SF12
type: RelationshipXref
id: PTHR11256:SF12
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__HDC-RIGHT__HDC-_re437
controller: SP1

CLU
type: RnaRegion
entity reference: CLU
cellular location: CELL
comment: SPECIES_TYPE=RNA

PTHR11256:SF11
type: RelationshipXref
id: PTHR11256:SF11
db: PANTHER Family
relationship type: By Homology

S45 beta catenin s1862 sa635 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S45
feature location: S45 beta catenin s1862 sa635 rs3 S45
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S45
comment: MODIFICATION_RESIDUE_ANGLE=3.845512436090568

S497 9 RAF1 s1330 sa689 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S497 9
feature location: S497 9 RAF1 s1330 sa689 rs8 S497 9
comment: MODIFICATION_RESIDUE_ANGLE=6.261510357865046
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S497/9

CCK-22
type: Protein
entity reference: CCK-22
feature: ACTIVE 13
comment: SPECIES_TYPE=PROTEIN

INHIBITION
type: Control
xref: INHIBITION
controlled: DISSOCIATION_LEFT__NFKB1_RELA_IKB_complex-RIGHT__NFKB_RELA_heterodimer-_IKBalpha-_re384
control type: INHIBITION
controller: PKCalpha

Y402 FAK2 s1203 sa519 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y402
feature location: Y402 FAK2 s1203 sa519 rs1 Y402
comment: MODIFICATION_RESIDUE_ANGLE=2.37
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y402

PARTICIPANT STOICHIOMETRY re609 879
type: Stoichiometry
physical entity: IEX1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re609 878
type: Stoichiometry
physical entity: IEX1
stoichiometric coefficient: 1.0

SHC1 @EGFR
type: Protein
entity reference: SHC1 @EGFR
feature: Y317 SHC1 @EGFR s882 sa108 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

AKT1-PIP3
type: Complex
component stoichiometry: PI3,4,5 P3 s1765 sa300 STOICHIOMETRY ID COMPLEX
component stoichiometry: AKT1 s913 sa301 STOICHIOMETRY ID COMPLEX
component: AKT1
component: PI3,4,5-P3
feature: COMPLEX BINDING FEATURE s1940 csa21 337
feature: COMPLEX BINDING FEATURE s1940 csa21 335
cellular location: CELL

Glucose
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__Phospholipid-RIGHT__AA-_re544
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re544 964
participant stoichiometry: PARTICIPANT STOICHIOMETRY re544 963
left: Phospholipid s1997 sa998
interaction type: STATE_TRANSITION
right: AA

BAD/BCL2L1 heterodimer
type: Complex
component stoichiometry: BAD s1612 sa892 STOICHIOMETRY ID COMPLEX
component stoichiometry: BCL2L1 s1773 sa896 STOICHIOMETRY ID COMPLEX
component: BAD
component: BCL2L1
feature: COMPLEX BINDING FEATURE s1966 csa74 223
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s1966 csa74 221
cellular location: Mitochondria

Y1254 PLCgamma1 s716 sa18 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y1254
feature location: Y1254 PLCgamma1 s716 sa18 rs4 Y1254
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y1254
comment: MODIFICATION_RESIDUE_ANGLE=5.61

STATE_TRANSITION_LEFT__YES1-RIGHT__YES1-_re638
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re638 732
participant stoichiometry: PARTICIPANT STOICHIOMETRY re638 731
left: YES1
interaction type: STATE_TRANSITION
right: YES1

UNKNOWN_CATALYSIS
type: TemplateReactionRegulation
xref: UNKNOWN CATALYSIS
controlled: TRANSCRIPTION_LEFT__CCND1-RIGHT__CCND1-_re421
controller: PAK1

PARTICIPANT STOICHIOMETRY re17 901
type: Stoichiometry
physical entity: Novel PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 902
type: Stoichiometry
physical entity: PKCepsilon
stoichiometric coefficient: 1.0

EGR1 s1705 sa336 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.7383466605211034

ncbitaxon 9606 10
type: UnificationXref
id: 9606
db: ncbitaxon

BAD s1612 sa892 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

ODC1
type: ProteinReference
xref: P07221
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.ODC1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ornithine decarboxylase

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__PAI2-RIGHT__PAI2-_re225
control type: INHIBITION
controller: MEN1

INHIBITION
type: Control
xref: INHIBITION
controlled: TRANSPORT_LEFT__Cytochrome_C-RIGHT__Cytochrome_C-_re633
control type: INHIBITION
controller: BCL2L1

FAK2
type: Protein
entity reference: FAK2
feature: Y580 FAK2 s1892 sa975 rs3
feature: Y881 FAK2 s1892 sa975 rs4
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s1892 sa975 388
feature: Y579 FAK2 s1892 sa975 rs2
feature: Y402 FAK2 s1892 sa975 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_re453
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re453 1150
participant stoichiometry: PARTICIPANT STOICHIOMETRY re453 1151
left: SRF
interaction type: STATE_TRANSITION
right: SRF

STATE_TRANSITION_LEFT__SRF-RIGHT__SRF-_re454
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re454 1149
participant stoichiometry: PARTICIPANT STOICHIOMETRY re454 1148
left: SRF
interaction type: STATE_TRANSITION
right: SRF

PARTICIPANT STOICHIOMETRY re415 1203
type: Stoichiometry
physical entity: MAPK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re415 1204
type: Stoichiometry
physical entity: MAPK3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re415 1205
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 1.0

MAPK1 3 s1788 sa954 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 2.0

S281 MAP3K11 s961 sa221 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S281
feature location: S281 MAP3K11 s961 sa221 rs2 S281
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S281
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.59771503510726

PAI1
type: RnaRegion
entity reference: PAI1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

RAC1-GTP
type: Protein
entity reference: RAC1-GTP
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

MAPK1/3
type: Protein
entity reference: MAPK1/3
feature: ACTIVE 13
feature: T202 MAPK1 3 s1857 sa216 rs3
feature: Y204 MAPK1 3 s1857 sa216 rs4

uniprot O00255 66
type: UnificationXref
id: O00255
db: uniprot

VMAT2
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.VMAT2
comment: ENTITY_REFERENCE_NOTES=

T71 ATF2 s1283 sa757 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T71
feature location: T71 ATF2 s1283 sa757 rs2 T71
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5248232251383325
comment: MODIFICATION_RESIDUE_NAME=T71

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK2_SRC_complex-RIGHT__FAK2_SRC_complex-_re311
controller: FAK2-SRC complex

CRK s1893 sa977 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRK
stoichiometric coefficient: 1.0

SRC @Galphaq s1599 sa887 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

S494 RAF1 s1330 sa689 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S494
feature location: S494 RAF1 s1330 sa689 rs5 S494
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.018263774283071
comment: MODIFICATION_RESIDUE_NAME=S494

PARTICIPANT STOICHIOMETRY re377 1215
type: Stoichiometry
physical entity: PLCbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re377 1214
type: Stoichiometry
physical entity: PLCbeta
stoichiometric coefficient: 1.0

SRF
type: Protein
entity reference: SRF
feature: S103 SRF s1059 sa745 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

S473 AKT1 s1739 sa165 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S473
feature location: S473 AKT1 s1739 sa165 rs2 S473
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S473
comment: MODIFICATION_RESIDUE_ANGLE=5.615596868291756

VMAT2
type: DnaRegion
entity reference: VMAT2 GENE
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

S494 RAF1 s742 sa680 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S494
feature location: S494 RAF1 s742 sa680 rs5 S494
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.018263774283071
comment: MODIFICATION_RESIDUE_NAME=S494

NFKB RELA heterodimer s1942 csa82 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NFKB RELA heterodimer s1942 csa82
stoichiometric coefficient: 1.0

CXCL2
type: RnaRegion
entity reference: CXCL2
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

Y91 Pre pro CCK @ ER s1189 sa497 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y91
feature location: Y91 Pre pro CCK @ ER s1189 sa497 rs2 Y91
comment: MODIFICATION_RESIDUE_NAME=Y91
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7357097081620996

PTHR10845:SF43
type: RelationshipXref
id: PTHR10845:SF43
db: PANTHER Family
relationship type: By Homology

Y577 FAK1 s776 sa285 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y577
feature location: Y577 FAK1 s776 sa285 rs4 Y577
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.29
comment: MODIFICATION_RESIDUE_NAME=Y577

MKP
type: Protein
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

CXCL2
type: RnaRegion
entity reference: CXCL2
cellular location: CELL
comment: SPECIES_TYPE=RNA

PI3,4,5 P3 s903 sa307 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3,4,5-P3
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CCK-RIGHT__CCK_83-_re498
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re498 1014
participant stoichiometry: PARTICIPANT STOICHIOMETRY re498 1013
left: CCK
interaction type: STATE_TRANSITION
right: CCK-83

SRC @Galphaq
type: Protein
entity reference: SRC @Galphaq
feature: COMPLEX PARTICIPANT BINDING FEATURE s1599 sa887 440
feature: ACTIVE 13
feature: Y418 SRC @Galphaq s1599 sa887 rs3
feature: Y527 SRC @Galphaq s1599 sa887 rs2
feature: Y416 SRC @Galphaq s1599 sa887 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re366 510
type: Stoichiometry
physical entity: sa436_degraded
stoichiometric coefficient: 1.0

STAT3
type: Complex
component stoichiometry: STAT3 s1785 sa325 STOICHIOMETRY ID COMPLEX
component: STAT3
feature: ACTIVE 13
cellular location: NUCLEUS

PDPK1
type: ProteinReference
xref: P07162
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PDPK1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: 3-phosphoinositide-dependent protein kinase 1

AKT1 s913 sa301 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AKT1
stoichiometric coefficient: 1.0

S430 CCK1R s1672 sa775 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S430
feature location: S430 CCK1R s1672 sa775 rs4 S430
comment: MODIFICATION_RESIDUE_ANGLE=5.556558434920722
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S430

MCL1
type: Protein
feature: ACTIVE 13
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

SP1 s1694 sa344 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8281758411424073
comment: MODIFICATION_RESIDUE_NAME=

SHC1 @EGFR
type: ProteinReference
xref: P07083
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.SHC1_br_@EGFR
comment: ENTITY_REFERENCE_NOTES=
member entity reference: SHC-transforming protein 1

Y868 JAK2 s1633 sa153 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y868
feature location: Y868 JAK2 s1633 sa153 rs1 Y868
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.715273327379819
comment: MODIFICATION_RESIDUE_NAME=Y868

STAT3
type: Complex
component stoichiometry: STAT3 s676 sa323 STOICHIOMETRY ID COMPLEX
component: STAT3
feature: ACTIVE 13
cellular location: CELL

PARTICIPANT STOICHIOMETRY re410 1212
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re366 509
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

Calcium/calmodulin-dependent protein kinase type IV
type: ProteinReference
xref: PTHR24349:SF338
xref: uniprot Q16566 87
organism: Homo sapiens

MAPK1/3
type: Complex
component stoichiometry: MAPK1 3 s1857 sa216 STOICHIOMETRY ID COMPLEX
component: MAPK1/3
feature: ACTIVE 13
cellular location: CELL

MAPK1/3
type: Complex
component stoichiometry: MAPK1 3 s1788 sa954 STOICHIOMETRY ID COMPLEX
component: MAPK1/3
cellular location: NUCLEUS

PARTICIPANT STOICHIOMETRY re410 1213
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__G17___Gly-RIGHT__G17-_re46
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 768
participant stoichiometry: PARTICIPANT STOICHIOMETRY re46 767
left: G17 - Gly
interaction type: STATE_TRANSITION
right: G17

MAPK1/3
type: Complex
component stoichiometry: MAPK1 3 s828 sa326 STOICHIOMETRY ID COMPLEX
component: MAPK1/3
feature: ACTIVE 13
cellular location: NUCLEUS

PTHR11960:SF14
type: RelationshipXref
id: PTHR11960:SF14
db: PANTHER Family
relationship type: By Homology

T211 MAP2K6 s965 sa226 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T211
feature location: T211 MAP2K6 s965 sa226 rs2 T211
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T211
comment: MODIFICATION_RESIDUE_ANGLE=5.499324126489373
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

MAPK7
type: Complex
component stoichiometry: MAPK7 s1971 sa989 STOICHIOMETRY ID COMPLEX
component: MAPK7
feature: ACTIVE 13
cellular location: CELL

S256 FOXO1 s1990 sa994 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S256
feature location: S256 FOXO1 s1990 sa994 rs1 S256
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S256
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3089902527502986

MAPK7
type: Complex
component stoichiometry: MAPK7 s1972 sa990 STOICHIOMETRY ID COMPLEX
component: MAPK7
feature: ACTIVE 13
cellular location: NUCLEUS

PTHR24353:SF68
type: RelationshipXref
id: PTHR24353:SF68
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__COX2-RIGHT__COX2-_re432
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re432 1182
participant stoichiometry: PARTICIPANT STOICHIOMETRY re432 1183
left: COX2
interaction type: TRANSPORT
right: COX2

PI3K Class I s984 csa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3K Class I
stoichiometric coefficient: 1.0

S183 PRAS40 s648 sa176 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S183
feature location: S183 PRAS40 s648 sa176 rs1 S183
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S183
comment: MODIFICATION_RESIDUE_ANGLE=0.7431411193556561

PARTICIPANT STOICHIOMETRY re443 1169
type: Stoichiometry
physical entity: COX2
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__MYC-RIGHT__MYC-_re422
type: TemplateReaction
product: MYC
xref: TRANSCRIPTION
participant: MYC
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Y317 SHC1 s708 sa107 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y317
feature location: Y317 SHC1 s708 sa107 rs1 Y317
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y317
comment: MODIFICATION_RESIDUE_ANGLE=0.786798160123647

SOS1
type: Protein
entity reference: SOS1
feature: T SOS1 s744 sa110 rs1
feature: S SOS1 s744 sa110 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

IL8
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.IL8
comment: ENTITY_REFERENCE_NOTES=

T180 p38MAPK s998 sa227 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T180
feature location: T180 p38MAPK s998 sa227 rs2 T180
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T180
comment: MODIFICATION_RESIDUE_ANGLE=5.470355957928183

Mitogen-activated protein kinase kinase kinase 11
type: ProteinReference
xref: PTHR44329:SF46
xref: uniprot Q16584 63
organism: Homo sapiens

S112 BAD s1615 sa893 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S112
feature location: S112 BAD s1615 sa893 rs1 S112
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.538835828280262
comment: MODIFICATION_RESIDUE_NAME=S112

S SOS1 s890 sa281 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S SOS1 s890 sa281 rs2 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.511144255404544

CETP
type: Protein
entity reference: CETP
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

ATF2
type: Complex
component stoichiometry: ATF2 s1835 sa330 STOICHIOMETRY ID COMPLEX
component: ATF2
feature: ACTIVE 13
cellular location: NUCLEUS

ATF2
type: Complex
component stoichiometry: ATF2 s1283 sa757 STOICHIOMETRY ID COMPLEX
component: ATF2
feature: ACTIVE 13
cellular location: CELL

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re300 637
type: Stoichiometry
physical entity: AKAP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re300 638
type: Stoichiometry
physical entity: PKA Holoenzyme I
stoichiometric coefficient: 1.0

S727 PLA2 s1515 sa826 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S727
feature location: S727 PLA2 s1515 sa826 rs1 S727
comment: MODIFICATION_RESIDUE_NAME=S727
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.776265626613757

PARTICIPANT STOICHIOMETRY re443 1170
type: Stoichiometry
physical entity: HuR
stoichiometric coefficient: 1.0

CLU
type: ProteinReference
xref: P07069
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CLU
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Clusterin

PARTICIPANT STOICHIOMETRY re443 1171
type: Stoichiometry
physical entity: HuR-COX2
stoichiometric coefficient: 1.0

PTEN
type: ProteinReference
xref: P07071
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PTEN
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRAS40-RIGHT__PRAS40-_re122
controller: AKT1-PIP3

Gbeta/gamma
type: ProteinReference
xref: P07197
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.G_beta_/_gamma_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

IL8 s1079 sa732 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IL8
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re358 523
type: Stoichiometry
physical entity: SHP-2
stoichiometric coefficient: 1.0

EGFR
type: Complex
component stoichiometry: EGFR s727 sa266 STOICHIOMETRY ID COMPLEX
component: EGFR
feature: COMPLEX PARTICIPANT BINDING FEATURE s727 sa266 232
cellular location: CELL

c-RAF / RAF1
type: Protein
entity reference: c-RAF / RAF1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

SP1 s1287 sa346 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8281758411424073
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re152 948
type: Stoichiometry
physical entity: MAPK8-10
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re152 947
type: Stoichiometry
physical entity: MAPK8-10
stoichiometric coefficient: 1.0

ELAV-like protein 1
type: DnaReference
xref: PTHR10352:SF13
organism: Homo sapiens

Y332 CAS s764 sa117 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y332
feature location: Y332 CAS s764 sa117 rs3 Y332
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y332
comment: MODIFICATION_RESIDUE_ANGLE=3.809181092477624

STATE_TRANSITION_LEFT__NOS1-RIGHT__NOS1-_re355
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re355 529
participant stoichiometry: PARTICIPANT STOICHIOMETRY re355 528
left: NOS1
interaction type: STATE_TRANSITION
right: NOS1

Carboxypeptidase E
type: ProteinReference
xref: P07026
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Carboxypeptidase E
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Carboxypeptidase E

PARTICIPANT STOICHIOMETRY re358 522
type: Stoichiometry
physical entity: SHP-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re360 519
type: Stoichiometry
physical entity: TPC1/2
stoichiometric coefficient: 1.0

c-RAF / RAF1
type: Protein
entity reference: c-RAF / RAF1
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re360 518
type: Stoichiometry
physical entity: TPC1/2
stoichiometric coefficient: 1.0

PTHR24027:SF319
type: RelationshipXref
id: PTHR24027:SF319
db: PANTHER Family
relationship type: By Homology

UNKNOWN_CATALYSIS
type: TemplateReactionRegulation
xref: UNKNOWN CATALYSIS
controlled: TRANSCRIPTION LEFT REG1A-RIGHT REG1A- re568
controller: RHOA-GTP

PARTICIPANT STOICHIOMETRY re114 1096
type: Stoichiometry
physical entity: RHEB-GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re114 1095
type: Stoichiometry
physical entity: RHEB-GTP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re351
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re351 538
participant stoichiometry: PARTICIPANT STOICHIOMETRY re351 537
left: Ca2+
interaction type: STATE_TRANSITION
right: Ca2+

T308 AKT1 s905 sa305 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T308
feature location: T308 AKT1 s905 sa305 rs1 T308
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T308
comment: MODIFICATION_RESIDUE_ANGLE=0.8191115980742862

PKA-R2alpha/beta
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1528 sa834 460
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_TRANSITION_LEFT__CCK2R-RIGHT__TRAF6-_re532
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re532 1007
participant stoichiometry: PARTICIPANT STOICHIOMETRY re532 1008
left: CCK2R
interaction type: UNKNOWN_TRANSITION
right: TRAF6

PTHR12788:SF4
type: RelationshipXref
id: PTHR12788:SF4
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re556
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re556 936
participant stoichiometry: PARTICIPANT STOICHIOMETRY re556 935
left: IP3R
interaction type: STATE_TRANSITION
right: IP3R

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADP-RIGHT__NAADP-_re350
controller: CD38

p60 SRC
type: Protein
entity reference: p60 SRC
feature: Y527 p60 SRC s963 sa286 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s963 sa286 370
feature: ACTIVE 13
feature: Y416 p60 SRC s963 sa286 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y238 CCK2R s1369 sa563 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y238
feature location: Y238 CCK2R s1369 sa563 rs7 Y238
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789
comment: MODIFICATION_RESIDUE_NAME=Y238

Y77 CCK G s1194 sa503 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 CCK G s1194 sa503 rs1 Y77
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3886733616110365
comment: MODIFICATION_RESIDUE_NAME=Y77

ETS domain-containing protein Elk-1
type: ProteinReference
xref: PTHR11849:SF178
xref: uniprot P19419 84
organism: Homo sapiens

Y972 JAK2 s1634 sa152 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y972
feature location: Y972 JAK2 s1634 sa152 rs3 Y972
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y972
comment: MODIFICATION_RESIDUE_ANGLE=2.4459542802949104

S497 9 RAF1 s1721 sa694 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S497 9
feature location: S497 9 RAF1 s1721 sa694 rs8 S497 9
comment: MODIFICATION_RESIDUE_ANGLE=6.261510357865046
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S497/9

S380 RSK1 2 s538 sa212 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S380
feature location: S380 RSK1 2 s538 sa212 rs4 S380
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=1.8133457596088143
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S380

uniprot P36507 16
type: UnificationXref
id: P36507
db: uniprot

KNOWN_TRANSITION_OMITTED_LEFT__Conventional_PKC-RIGHT__PKCalpha-_re13
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 914
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 915
left: Conventional PKC
interaction type: KNOWN_TRANSITION_OMITTED
right: PKCalpha

STATE_TRANSITION
type: Control
xref: STATE TRANSITION
controlled: Proliferation
controller: FAK2-SRC complex

A-kinase anchor protein 1, mitochondrial
type: ProteinReference
xref: uniprot Q92667 81
xref: PTHR22948:SF57
organism: Homo sapiens

uniprot P31946 122
type: UnificationXref
id: P31946
db: uniprot

MAPK1
type: Protein
entity reference: MAPK1
feature: Y204 MAPK1 s831 sa201 rs2
feature: T202 MAPK1 s831 sa201 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

GRB2 s914 sa275 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

uniprot Q9BZL6 151
type: UnificationXref
id: Q9BZL6
db: uniprot

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Inflammatory response
controller: IL8

PARTICIPANT STOICHIOMETRY re598 753
type: Stoichiometry
physical entity: GAS-REBP3
stoichiometric coefficient: 1.0

cGMP-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q13976 49
xref: PTHR24353:SF68
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re598 754
type: Stoichiometry
physical entity: GAS-REBP3
stoichiometric coefficient: 1.0

Y204 MAPK1 3 s1857 sa216 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y204
feature location: Y204 MAPK1 3 s1857 sa216 rs4 Y204
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.500664060131579
comment: MODIFICATION_RESIDUE_NAME=Y204

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__ITGAV-RIGHT__ITGAV-_re593
controller: PI3K Class I

PARTICIPANT STOICHIOMETRY re532 1008
type: Stoichiometry
physical entity: TRAF6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re532 1007
type: Stoichiometry
physical entity: CCK2R
stoichiometric coefficient: 1.0

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

E-cadherin
type: RnaRegion
entity reference: E-cadherin
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re559 931
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 2.0

CCK-GRR
type: ProteinReference
xref: P07131
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CCK-GRR
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

PARTICIPANT STOICHIOMETRY re559 932
type: Stoichiometry
physical entity: BAX/BCL2L1 heterodimer
stoichiometric coefficient: 1.0

Y705 STAT3 s1785 sa325 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y705
feature location: Y705 STAT3 s1785 sa325 rs1 Y705
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.71
comment: MODIFICATION_RESIDUE_NAME=Y705

IP3R
type: Protein
entity reference: IP3R
feature: IP3R s1549 sa7 rs1
cellular location: Endoplasmic Reticulum
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION_LEFT__ITGAV-RIGHT__ITGAV-_re593
type: TemplateReaction
product: ITGAV s1636 sa911
xref: TRANSCRIPTION
participant: ITGAV s1636 sa911
participant: ITGAV
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re559 930
type: Stoichiometry
physical entity: BCL2L1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re623 787
type: Stoichiometry
physical entity: ELK1
stoichiometric coefficient: 1.0

Y91 Pro CCK @ secretory granule s1192 sa500 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y91
feature location: Y91 Pro CCK @ secretory granule s1192 sa500 rs2 Y91
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_NAME=Y91
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8108081039779539

SRC @Galphaq
type: Protein
entity reference: SRC @Galphaq
feature: Y527 SRC @Galphaq s1782 sa950 rs2
feature: Y418 SRC @Galphaq s1782 sa950 rs3
feature: Y416 SRC @Galphaq s1782 sa950 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re623 788
type: Stoichiometry
physical entity: ELK1
stoichiometric coefficient: 1.0

PKA-Calpha/beta/gamma
type: Protein
entity reference: PKA-Calpha/beta/gamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s1521 sa832 326
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re109 1113
type: Stoichiometry
physical entity: AKT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re109 1114
type: Stoichiometry
physical entity: PI3,4,5-P3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re109 1115
type: Stoichiometry
physical entity: AKT1-PIP3
stoichiometric coefficient: 1.0

HuR-COX2
type: Complex
component stoichiometry: COX2 s1078 sa729 STOICHIOMETRY ID COMPLEX
component stoichiometry: HuR s1075 sa730 STOICHIOMETRY ID COMPLEX
component: HuR
component: COX2
feature: COMPLEX BINDING FEATURE s1985 csa61 187
feature: COMPLEX BINDING FEATURE s1985 csa61 189
cellular location: CELL

uniprot P28324 47
type: UnificationXref
id: P28324
db: uniprot

Y416 YES1 s1995 sa984 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 YES1 s1995 sa984 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7450763826873115

Y579 FAK2 s1892 sa975 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y579
feature location: Y579 FAK2 s1892 sa975 rs2 Y579
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y579
comment: MODIFICATION_RESIDUE_ANGLE=3.84

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re405
controller: SRC

PARTICIPANT STOICHIOMETRY re375 1218
type: Stoichiometry
physical entity: E-cadherin
stoichiometric coefficient: 1.0

Carboxypeptidase E
type: ProteinReference
xref: PTHR11532:SF62
xref: uniprot P16870 38
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re141 990
type: Stoichiometry
physical entity: MAP2K2
stoichiometric coefficient: 1.0

Y1045 EGFR s727 sa266 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y1045
feature location: Y1045 EGFR s727 sa266 rs7 Y1045
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.884194828627882
comment: MODIFICATION_RESIDUE_NAME=Y1045

STATE_TRANSITION_LEFT__IKBalpha-RIGHT__sa342_degraded-_re41
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 778
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 777
left: IKBalpha
interaction type: STATE_TRANSITION
right: sa342_degraded

Y580 FAK2 s1203 sa519 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y580
feature location: Y580 FAK2 s1203 sa519 rs3 Y580
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y580
comment: MODIFICATION_RESIDUE_ANGLE=0.75

PARTICIPANT STOICHIOMETRY re375 1219
type: Stoichiometry
physical entity: E-cadherin
stoichiometric coefficient: 1.0

uniprot Q16566 87
type: UnificationXref
id: Q16566
db: uniprot

S749 RSK1 2 s1856 sa215 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S749
feature location: S749 RSK1 2 s1856 sa215 rs6 S749
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=S749
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.408013221559381

STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_re574
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re574 849
participant stoichiometry: PARTICIPANT STOICHIOMETRY re574 848
left: HSP27
interaction type: STATE_TRANSITION
right: HSP27

HETERODIMER_ASSOCIATION_LEFT__MCL1-_BAX-RIGHT__BAX_MCL1_heterodimer-_re634
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re634 739
participant stoichiometry: PARTICIPANT STOICHIOMETRY re634 740
participant stoichiometry: PARTICIPANT STOICHIOMETRY re634 741
left: BAX
left: MCL1
interaction type: HETERODIMER_ASSOCIATION
right: BAX/MCL1 heterodimer

CaMKIV s2008 sa1006 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=0.774879437994804
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

STATE_TRANSITION_LEFT__GMP-RIGHT__cGMP-_re352
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re352 536
participant stoichiometry: PARTICIPANT STOICHIOMETRY re352 535
left: GMP
interaction type: STATE_TRANSITION
right: cGMP

STATE_TRANSITION_LEFT__PPARgamma-RIGHT__PPARgamma-_re483
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re483 1060
participant stoichiometry: PARTICIPANT STOICHIOMETRY re483 1059
left: PPARgamma
interaction type: STATE_TRANSITION
right: PPARgamma

S437 CCK2R s1660 sa22 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S437
feature location: S437 CCK2R s1660 sa22 rs4 S437
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S437
comment: MODIFICATION_RESIDUE_ANGLE=3.6969103423572474
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__CD38-RIGHT__CD38-_re356
control type: ACTIVATION
controller: cGMP

Integrin alpha-V
type: ProteinReference
xref: uniprot P06756 129
xref: PTHR23220:SF4
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re141 989
type: Stoichiometry
physical entity: MAP2K2 s988 sa206
stoichiometric coefficient: 1.0

uniprot P0DP23 158
type: UnificationXref
id: P0DP23
db: uniprot

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK8_10-RIGHT__MAPK8_10-_re152
controller: CCK1R

Interleukin-8
type: ProteinReference
xref: PTHR10179:SF42
xref: uniprot P10145 51
organism: Homo sapiens

MMP3
type: Protein
entity reference: MMP3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S82 HSP27 s1585 sa872 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S82
feature location: S82 HSP27 s1585 sa872 rs3 S82
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7447925440653353
comment: MODIFICATION_RESIDUE_NAME=S82

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__BAD_BCL2_heterodimer-RIGHT__BAD_BCL2_heterodimer-_re564
controller: AKT1-PIP3

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__MMP7-RIGHT__MMP7-_re418
controller: SNAI1

Y972 JAK2 s1633 sa153 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y972
feature location: Y972 JAK2 s1633 sa153 rs3 Y972
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y972
comment: MODIFICATION_RESIDUE_ANGLE=2.4459542802949104

EGFR
type: Protein
feature: Y1173 EGFR s727 sa266 rs12
feature: Y891 EGFR s727 sa266 rs4
feature: Y1068 EGFR s727 sa266 rs8
feature: Y1045 EGFR s727 sa266 rs7
feature: Y1148 EGFR s727 sa266 rs11
feature: Y1086 EGFR s727 sa266 rs9
feature: Y845 EGFR s727 sa266 rs3
feature: T654 EGFR s727 sa266 rs1
feature: K721 EGFR s727 sa266 rs2
feature: Y1101 EGFR s727 sa266 rs10
feature: Y992 EGFR s727 sa266 rs6
feature: Y920 EGFR s727 sa266 rs5

PI3K Class I
type: Complex
component stoichiometry: p85 s885 sa298 STOICHIOMETRY ID COMPLEX
component stoichiometry: p110 s886 sa299 STOICHIOMETRY ID COMPLEX
component: p110
component: p85
feature: COMPLEX BINDING FEATURE s941 csa20 203
feature: COMPLEX BINDING FEATURE s941 csa20 201
cellular location: CELL

STAT3
type: Protein
entity reference: STAT3
feature: Y725 STAT3 s674 sa181 rs2
feature: Y705 STAT3 s674 sa181 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__CCND1-RIGHT__CCND1-_re424
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re424 1186
participant stoichiometry: PARTICIPANT STOICHIOMETRY re424 1187
left: CCND1
interaction type: TRANSPORT
right: CCND1

TRANSPORT_LEFT__HuR-RIGHT__HuR-_re429
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re429 1185
participant stoichiometry: PARTICIPANT STOICHIOMETRY re429 1184
left: HuR
interaction type: TRANSPORT
right: HuR

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION LEFT REG1A-RIGHT REG1A- re568
controller: SP3

S73 JUN s1041 sa340 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S73
feature location: S73 JUN s1041 sa340 rs2 S73
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.53026601520083
comment: MODIFICATION_RESIDUE_NAME=S73

INHIBITION
type: Control
xref: INHIBITION
control type: INHIBITION
controller: IEX1

PARTICIPANT STOICHIOMETRY re463 1134
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

BAX
type: ProteinReference
xref: P07159
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.BAX
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Apoptosis regulator BAX

MMP3
type: Protein
entity reference: MMP3
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re463 1133
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

Tyrosine-protein phosphatase non-receptor type 11
type: ProteinReference
xref: uniprot Q06124 128
xref: PTHR46559:SF1
organism: Homo sapiens

p52 SHC1
type: Protein
entity reference: p52 SHC1
feature: Y239 240 p52 SHC1 s711 sa104 rs2
feature: Y317 p52 SHC1 s711 sa104 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re68 675
type: Stoichiometry
physical entity: Complex (GRB2/SOS1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re411 1208
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re68 676
type: Stoichiometry
physical entity: p46 SHC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re411 1209
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re68 677
type: Stoichiometry
physical entity: p46SHC1-GRB2-SOS1
stoichiometric coefficient: 1.0

Retinal guanylyl cyclase 1
type: ProteinReference
xref: PTHR11920:SF228
xref: uniprot Q02846 34
organism: Homo sapiens

S221 HuR s1073 sa731 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 HuR s1073 sa731 rs2 S221
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.58
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221

PARTICIPANT STOICHIOMETRY re313 592
type: Stoichiometry
physical entity: FAK2
stoichiometric coefficient: 1.0

STAT3
type: ProteinReference
xref: P07165
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.STAT3
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Signal transducer and activator of transcription 3

PARTICIPANT STOICHIOMETRY re313 591
type: Stoichiometry
physical entity: FAK2
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__G17-RIGHT__s21-_re335
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re335 549
participant stoichiometry: PARTICIPANT STOICHIOMETRY re335 550
left: G17
interaction type: UNKNOWN_TRANSITION
right: s21

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Migration
controller: CAS-CRK complex

CCK-G
type: Protein
entity reference: CCK-G
feature: Y77 CCK G s1194 sa503 rs1
feature: Y94 CCK G s1194 sa503 rs3
feature: Y91 CCK G s1194 sa503 rs2
comment: SPECIES_TYPE=PROTEIN

S442 CCK2R s1688 sa565 rs10
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S442
feature location: S442 CCK2R s1688 sa565 rs10 S442
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=6.097097937454755
comment: MODIFICATION_RESIDUE_NAME=S442

S73 JUN s1859 sa235 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S73
feature location: S73 JUN s1859 sa235 rs2 S73
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.53026601520083
comment: MODIFICATION_RESIDUE_NAME=S73

DISSOCIATION_LEFT__BAD_BCL2L1_heterodimer-RIGHT__BCL2L1-_BAD-_re579
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re579 840
participant stoichiometry: PARTICIPANT STOICHIOMETRY re579 838
participant stoichiometry: PARTICIPANT STOICHIOMETRY re579 839
left: BAD/BCL2L1 heterodimer
interaction type: DISSOCIATION
right: BCL2L1
right: BAD

Eukaryotic translation initiation factor 4E
type: ProteinReference
xref: uniprot P06730 28
xref: PTHR11960:SF14
organism: Homo sapiens

TRANSCRIPTION_LEFT__COX2-RIGHT__COX2-_re425
type: TemplateReaction
product: COX2
xref: TRANSCRIPTION
participant: COX2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Pancreatic enzyme secretion
controller: CaMKIV

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RAC1_GDP-_GTP-RIGHT__RAC1_GTP-_GDP-_re76
controller: CCK2R

UNKNOWN_TRANSITION_LEFT__p38MAPK-RIGHT__AKT1_PIP3-_re601
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re601 885
participant stoichiometry: PARTICIPANT STOICHIOMETRY re601 884
left: p38MAPK s998 sa227
interaction type: UNKNOWN_TRANSITION
right: AKT1-PIP3

S494 RAF1 s731 sa687 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S494
feature location: S494 RAF1 s731 sa687 rs5 S494
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.018263774283071
comment: MODIFICATION_RESIDUE_NAME=S494

PARTICIPANT STOICHIOMETRY re203 897
type: Stoichiometry
physical entity: MEF2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re203 896
type: Stoichiometry
physical entity: MEF2B
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Gbeta_gamma-_Galpha_q_complex-RIGHT__Pi-_G_Protein_complex-_re612
controller: RGS2

CATALYSIS
type: RelationshipTypeVocabulary

Y341 RAF1 s1330 sa689 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y341
feature location: Y341 RAF1 s1330 sa689 rs2 Y341
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y341
comment: MODIFICATION_RESIDUE_ANGLE=0.813361255902311

MAPK7
type: Protein
entity reference: MAPK7
feature: ACTIVE 13
feature: T219 MAPK7 s1971 sa989 rs1
feature: Y221 MAPK7 s1971 sa989 rs2

PAM
type: Protein
comment: SPECIES_TYPE=PROTEIN

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P17252 19
organism: Homo sapiens

PI3,4,5 P3 s1765 sa300 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3,4,5-P3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re67 680
type: Stoichiometry
physical entity: p52SHC1-GRB2-SOS1
stoichiometric coefficient: 1.0

MEF2D
type: ProteinReference
xref: P07048
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MEF2D
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Myocyte-specific enhancer factor 2D

TRANSPORT_LEFT__PLA2-RIGHT__PLA2-_re543
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re543 965
participant stoichiometry: PARTICIPANT STOICHIOMETRY re543 966
left: PLA2
interaction type: TRANSPORT
right: PLA2 s1516 sa827

PARTICIPANT STOICHIOMETRY re67 678
type: Stoichiometry
physical entity: Complex (GRB2/SOS1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re67 679
type: Stoichiometry
physical entity: p52 SHC1 s721 sa101
stoichiometric coefficient: 1.0

S383 ELK1 s197 sa333 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S383
feature location: S383 ELK1 s197 sa333 rs1 S383
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S383
comment: MODIFICATION_RESIDUE_ANGLE=0.7039197825007742

STATE_TRANSITION
type: InteractionVocabulary

TRANSPORT
type: InteractionVocabulary

S259 RAF1 s1336 sa692 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S259
feature location: S259 RAF1 s1336 sa692 rs3 S259
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S259
comment: MODIFICATION_RESIDUE_ANGLE=2.328231397687482

RHOA-GDP
type: ProteinReference
xref: P07019
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RHOA-GDP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Transforming protein RhoA

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK2-RIGHT__FAK2-_re313
controller: FAK2

HSP27
type: Protein
entity reference: HSP27
feature: S15 HSP27 s1585 sa872 rs1
feature: S82 HSP27 s1585 sa872 rs3
feature: S78 HSP27 s1585 sa872 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot Q16539 80
organism: Homo sapiens

S338 RAF1 s1336 sa692 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S338
feature location: S338 RAF1 s1336 sa692 rs1 S338
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S338
comment: MODIFICATION_RESIDUE_ANGLE=1.5707963267948966

CETP
type: Protein
entity reference: CETP
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION_LEFT__IL8-RIGHT__IL8-_re426
type: TemplateReaction
product: IL8
xref: TRANSCRIPTION
participant: IL8
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Y1086 EGFR s727 sa266 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y1086
feature location: Y1086 EGFR s727 sa266 rs9 Y1086
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.289887629941637
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y1086

IKKbeta s1813 sa259 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IKKbeta
stoichiometric coefficient: 1.0

SOS1 s894 sa270 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS1
stoichiometric coefficient: 1.0

S2481 mTOR s644 sa311 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S2481
feature location: S2481 mTOR s644 sa311 rs2 S2481
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8251814037002603
comment: MODIFICATION_RESIDUE_NAME=S2481

PARTICIPANT STOICHIOMETRY re8 486
type: Stoichiometry
physical entity: PKCdelta
stoichiometric coefficient: 1.0

S43 RAF1 s155 sa679 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S43
feature location: S43 RAF1 s155 sa679 rs6 S43
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.908388522052502
comment: MODIFICATION_RESIDUE_NAME=S43

PARTICIPANT STOICHIOMETRY re8 487
type: Stoichiometry
physical entity: PKCdelta
stoichiometric coefficient: 1.0

EGFR s727 sa266 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

PTHR22803:SF105
type: RelationshipXref
id: PTHR22803:SF105
db: PANTHER Family
relationship type: By Homology

KNOWN_TRANSITION_OMITTED_LEFT__SRC_@Galphaq-RIGHT__p54_SRC-_re53
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re53 723
participant stoichiometry: PARTICIPANT STOICHIOMETRY re53 724
left: SRC @Galphaq
interaction type: KNOWN_TRANSITION_OMITTED
right: p54 SRC

IRS1
type: Protein
entity reference: IRS1
feature: Y IRS1 s939 sa155 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PRAS40-RIGHT__PRAS40-_re121
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re121 1066
participant stoichiometry: PARTICIPANT STOICHIOMETRY re121 1065
left: PRAS40
interaction type: STATE_TRANSITION
right: PRAS40

GRB2
type: ProteinReference
xref: P07237
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.GRB2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Growth factor receptor-bound protein 2

S221 HuR s1075 sa730 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 HuR s1075 sa730 rs2 S221
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.58
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221

STATE_TRANSITION_LEFT__PRAS40-RIGHT__PRAS40-_re122
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re122 1064
participant stoichiometry: PARTICIPANT STOICHIOMETRY re122 1063
left: PRAS40
interaction type: STATE_TRANSITION
right: PRAS40

TRANSCRIPTION_LEFT__TACR1-RIGHT__TACR1-_re511
type: TemplateReaction
product: TACR1
xref: TRANSCRIPTION
participant: TACR1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

HuR
type: RnaRegion
entity reference: HuR
cellular location: CELL
comment: SPECIES_TYPE=RNA

Y77 CCK s1911 sa947 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 CCK s1911 sa947 rs1 Y77
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3832305715485393
comment: MODIFICATION_RESIDUE_NAME=Y77

Signal-pre-pro CCK
type: ProteinReference
xref: P07223
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Signal-pre-pro CCK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

PKCbeta
type: Protein
entity reference: PKCbeta
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y341 RAF1 s156 sa686 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y341
feature location: Y341 RAF1 s156 sa686 rs2 Y341
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y341
comment: MODIFICATION_RESIDUE_ANGLE=0.813361255902311

TFF1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.TFF1
comment: ENTITY_REFERENCE_NOTES=

beta-catenin
type: Protein
entity reference: beta-catenin
feature: S45 beta catenin s1315 sa638 rs3
feature: S37 beta catenin s1315 sa638 rs1
feature: T41 beta catenin s1315 sa638 rs4
feature: S33 beta catenin s1315 sa638 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1315 sa638 454
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

uniprot Q13976 49
type: UnificationXref
id: Q13976
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE TRANSITION LEFT JAK2-RIGHT JAK2- re98
controller: Galpha q complex

MYC
type: RnaRegion
entity reference: MYC
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

T24 FOXO1 s1990 sa994 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T24
feature location: T24 FOXO1 s1990 sa994 rs3 T24
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.79
comment: MODIFICATION_RESIDUE_NAME=T24

S363 RSK1 2 s537 sa211 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S363
feature location: S363 RSK1 2 s537 sa211 rs1 S363
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=2.378634437717986
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S363

IKBalpha s844 sa252 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IKBalpha
stoichiometric coefficient: 1.0

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION LEFT REG1A-RIGHT REG1A- re568
controller: SP1

PARTICIPANT STOICHIOMETRY re39 806
type: Stoichiometry
physical entity: NFKB1-RELA-IKB complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re39 805
type: Stoichiometry
physical entity: NFKB1-RelA-IKB complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re353 534
type: Stoichiometry
physical entity: Guanylate cyclase s1903 sa624
stoichiometric coefficient: 1.0

CaN s2014 sa1011 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CaN
stoichiometric coefficient: 1.0

S43 RAF1 s731 sa687 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S43
feature location: S43 RAF1 s731 sa687 rs6 S43
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.908388522052502
comment: MODIFICATION_RESIDUE_NAME=S43

PARTICIPANT STOICHIOMETRY re353 533
type: Stoichiometry
physical entity: Guanylate cyclase s1903 sa623
stoichiometric coefficient: 1.0

NFAT1
type: ProteinReference
xref: P07176
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.NFAT1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Nuclear factor of activated T-cells, cytoplasmic 2

Beta-arrestin-1/2
type: Protein
entity reference: Beta-arrestin-1/2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1412 sa570 230
cellular location: Endosome
comment: SPECIES_TYPE=PROTEIN

Y416 SRC @Galphaq s719 sa95 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 SRC @Galphaq s719 sa95 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789

PARTICIPANT STOICHIOMETRY re586 799
type: Stoichiometry
physical entity: CDC42-GTP
stoichiometric coefficient: 1.0

S45 beta catenin s1273 sa637 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S45
feature location: S45 beta catenin s1273 sa637 rs3 S45
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S45
comment: MODIFICATION_RESIDUE_ANGLE=3.845512436090568

BCL2
type: Protein
entity reference: BCL2
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s808 sa294 244
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

T268 9 RAF1 s155 sa679 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T268 9
feature location: T268 9 RAF1 s155 sa679 rs7 T268 9
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T268/9
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Pro CCK @ TGN
type: ProteinReference
xref: P07174
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Pro CCK @ TGN
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

Myocyte-specific enhancer factor 2D
type: ProteinReference
xref: PTHR11945:SF23
xref: uniprot Q14814 125
organism: Homo sapiens

FOS
type: RnaRegion
entity reference: FOS
cellular location: CELL
comment: SPECIES_TYPE=RNA

Y94 CCK G s1194 sa503 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 CCK G s1194 sa503 rs3 Y94
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.508305869184782
comment: MODIFICATION_RESIDUE_NAME=Y94

uniprot P01100 154
type: UnificationXref
id: P01100
db: uniprot

UNKNOWN_CATALYSIS
type: TemplateReactionRegulation
xref: UNKNOWN CATALYSIS
controlled: TRANSCRIPTION_LEFT__PAI1-RIGHT__PAI1-_re603
controller: MAPK1/3

4E BP1 s964 sa315 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.786798160123647

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Progastrin_@Golgi-RIGHT__G34_Gly-_re479
controller: Prohormone convertase

MCL1
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1568 sa968 378
feature: ACTIVE 13
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s2013 sa1010 422
cellular location: CELL
comment: SPECIES_TYPE=ION

PARTICIPANT STOICHIOMETRY re651 669
type: Stoichiometry
physical entity: FOXO3
stoichiometric coefficient: 1.0

p66 SHC1
type: Protein
entity reference: p66 SHC1
feature: Y317 p66 SHC1 s713 sa102 rs1
feature: Y239 240 p66 SHC1 s713 sa102 rs2
feature: S36 p66 SHC1 s713 sa102 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y416 SRC @Galphaq s1782 sa950 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 SRC @Galphaq s1782 sa950 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789

CRK s772 sa288 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CRK s772 sa288
stoichiometric coefficient: 1.0

Myocyte-specific enhancer factor 2B
type: ProteinReference
xref: uniprot Q02080 161
organism: Homo sapiens

S136 BAD s790 sa150 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S136
feature location: S136 BAD s790 sa150 rs2 S136
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8079058030724882
comment: MODIFICATION_RESIDUE_NAME=S136

ODC1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.ODC1
comment: ENTITY_REFERENCE_NOTES=

Y G17 s1411 sa569 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y G17 s1411 sa569 rs1 Y
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.7742892784837644

PARTICIPANT STOICHIOMETRY re367 508
type: Stoichiometry
physical entity: E-cadherin
stoichiometric coefficient: 1.0

S621 RAF1 s154 sa685 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S621
feature location: S621 RAF1 s154 sa685 rs9 S621
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S621
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.46201537231871

PARTICIPANT STOICHIOMETRY re367 507
type: Stoichiometry
physical entity: E-cadherin
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P28482 140
organism: Homo sapiens

S710 PRKD2 s1820 sa695 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S710
feature location: S710 PRKD2 s1820 sa695 rs3 S710
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3074279375630917
comment: MODIFICATION_RESIDUE_NAME=S710

BAX/BCL2L1 heterodimer
type: Complex
component stoichiometry: HOMODIMER ID 90STOICHIOMETRY ID COMPLEX
component stoichiometry: BCL2L1 s801 sa292 STOICHIOMETRY ID COMPLEX
component: BAX
component: BCL2L1
feature: COMPLEX BINDING FEATURE s1962 csa17 255
feature: COMPLEX BINDING FEATURE s1962 csa17 253
cellular location: Mitochondria

S37 beta catenin s932 sa321 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S37
feature location: S37 beta catenin s932 sa321 rs1 S37
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S37

S727 PLA2 s1516 sa827 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S727
feature location: S727 PLA2 s1516 sa827 rs1 S727
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S727
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.776265626613757

FAK2-SRC complex
type: Complex
component stoichiometry: FAK2 s1604 sa880 STOICHIOMETRY ID COMPLEX
component stoichiometry: SRC @Galphaq s1769 sa881 STOICHIOMETRY ID COMPLEX
component: FAK2 s1604 sa880
component: SRC @Galphaq
feature: COMPLEX BINDING FEATURE s1953 csa71 281
feature: COMPLEX BINDING FEATURE s1953 csa71 279
cellular location: CELL

JUN s1041 sa340 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re591 770
type: Stoichiometry
physical entity: BCL2L1
stoichiometric coefficient: 1.0

T573 RSK1 2 s536 sa209 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T573
feature location: T573 RSK1 2 s536 sa209 rs3 T573
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=T573

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__CLU-RIGHT__CLU-_re569
controller: AP1 (FOS+JUN)

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Galpha13beta_gamma-_GTP-RIGHT__Galpha13-_GDP-_Gbeta_gamma-_re337
controller: CCK1R

Y397 FAK1 s669 sa111 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y397
feature location: Y397 FAK1 s669 sa111 rs1 Y397
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.47
comment: MODIFICATION_RESIDUE_NAME=Y397
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

T219 MAPK7 s1972 sa990 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T219
feature location: T219 MAPK7 s1972 sa990 rs1 T219
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.387506044879286
comment: MODIFICATION_RESIDUE_NAME=T219

S338 RAF1 s156 sa686 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S338
feature location: S338 RAF1 s156 sa686 rs1 S338
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S338
comment: MODIFICATION_RESIDUE_ANGLE=1.5707963267948966

MCL1
type: RnaRegion
entity reference: MCL1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

uPA
type: ProteinReference
xref: P07039
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.uPA
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Urokinase-type plasminogen activator

PARTICIPANT STOICHIOMETRY re362 517
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re540 974
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__active_CCK2R_beta_arrestin_complex-RIGHT__active_CCK2R_Beta_arrestin_complex-_re332
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re332 553
participant stoichiometry: PARTICIPANT STOICHIOMETRY re332 554
left: active CCK2R beta arrestin complex s1687 csa54
interaction type: TRANSPORT
right: active CCK2R/Beta-arrestin complex

PARTICIPANT STOICHIOMETRY re362 516
type: Stoichiometry
physical entity: E-cadherin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re540 973
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re362 515
type: Stoichiometry
physical entity: E-cadherin/beta-catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re573 851
type: Stoichiometry
physical entity: MAPKAP-K2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re573 850
type: Stoichiometry
physical entity: MAPKAP-K2
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 139
organism: Homo sapiens

SHC1 @EGFR s892 sa268 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SHC1 @EGFR
stoichiometric coefficient: 1.0

CK1delta/epsilon
type: ProteinReference
xref: P07089
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CK1_delta_/_epsilon_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Casein kinase I isoform epsilon
member entity reference: Casein kinase I isoform delta

T183 MAPK8 10 s692 sa223 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T183
feature location: T183 MAPK8 10 s692 sa223 rs1 T183
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T183
comment: MODIFICATION_RESIDUE_ANGLE=0.8048507494877875

MAPK8-10
type: Protein
entity reference: MAPK8-10
feature: T183 MAPK8 10 s692 sa223 rs1
feature: Y185 MAPK8 10 s692 sa223 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

MAP2K1
type: Protein
entity reference: MAP2K1 PROTEIN
feature: S222 MAP2K1 s822 sa204 rs2
feature: S218 MAP2K1 s822 sa204 rs1
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re74 656
type: Stoichiometry
physical entity: RHOA-GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re74 657
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re74 658
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re74 659
type: Stoichiometry
physical entity: RHOA-GTP
stoichiometric coefficient: 1.0

Y118 Paxillin s671 sa114 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y118
feature location: Y118 Paxillin s671 sa114 rs2 Y118
comment: MODIFICATION_RESIDUE_NAME=Y118
comment: MODIFICATION_RESIDUE_ANGLE=5.490568410662676
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

Cholesteryl ester transfer protein
type: ProteinReference
xref: uniprot P11597 94
xref: PTHR47616:SF1
organism: Homo sapiens

Clusterin
type: DnaReference
xref: PTHR10970:SF1
organism: Homo sapiens

uPA
type: Protein
entity reference: uPA
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__FOXO3-RIGHT__FOXO3-_re651
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re651 669
participant stoichiometry: PARTICIPANT STOICHIOMETRY re651 670
left: FOXO3
interaction type: TRANSPORT
right: FOXO3

PTHR10786:SF0
type: RelationshipXref
id: PTHR10786:SF0
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pro_HBEGF-RIGHT___HBEGF-_re49
controller: MMP3

Y390 CCK2R s1688 sa565 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y390
feature location: Y390 CCK2R s1688 sa565 rs1 Y390
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4010743852436276
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y390

Y238 CCK2R s1410 sa568 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y238
feature location: Y238 CCK2R s1410 sa568 rs7 Y238
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789
comment: MODIFICATION_RESIDUE_NAME=Y238

PARTICIPANT STOICHIOMETRY re19 890
type: Stoichiometry
physical entity: Conventional PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 891
type: Stoichiometry
physical entity: Conventional PKC
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re406
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re406 501
participant stoichiometry: PARTICIPANT STOICHIOMETRY re406 502
left: RAF1
interaction type: STATE_TRANSITION
right: RAF1

STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re405
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re405 503
participant stoichiometry: PARTICIPANT STOICHIOMETRY re405 504
left: RAF1
interaction type: STATE_TRANSITION
right: RAF1

STATE_TRANSITION_LEFT__MAP2K2-RIGHT__MAP2K2-_re141
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re141 990
participant stoichiometry: PARTICIPANT STOICHIOMETRY re141 989
left: MAP2K2 s988 sa206
interaction type: STATE_TRANSITION
right: MAP2K2

STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re408
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re408 498
participant stoichiometry: PARTICIPANT STOICHIOMETRY re408 497
left: RAF1
interaction type: STATE_TRANSITION
right: RAF1

STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re407
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re407 499
participant stoichiometry: PARTICIPANT STOICHIOMETRY re407 500
left: RAF1
interaction type: STATE_TRANSITION
right: RAF1

STATE_TRANSITION_LEFT__SRC_@Galphaq-RIGHT__SRC_@Galphaq-_re613
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re613 832
participant stoichiometry: PARTICIPANT STOICHIOMETRY re613 833
left: SRC @Galphaq
interaction type: STATE_TRANSITION
right: SRC @Galphaq

JUN
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.JUN
comment: ENTITY_REFERENCE_NOTES=

T41 beta catenin s1852 sa183 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T41
feature location: T41 beta catenin s1852 sa183 rs4 T41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T41
comment: MODIFICATION_RESIDUE_ANGLE=2.3739822534748654

PARTICIPANT STOICHIOMETRY re38 810
type: Stoichiometry
physical entity: IkB kinase complex
stoichiometric coefficient: 1.0

4E-BP1
type: Protein
entity reference: 4E-BP1
feature: ACTIVE 13
feature: 4E BP1 s964 sa315 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s964 sa315 428
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__STAT3-RIGHT__STAT3-_re161
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re161 929
participant stoichiometry: PARTICIPANT STOICHIOMETRY re161 928
left: STAT3
interaction type: STATE_TRANSITION
right: STAT3

STAT3
type: Protein
entity reference: STAT3
feature: ACTIVE 13
feature: Y725 STAT3 s675 sa180 rs2
feature: Y705 STAT3 s675 sa180 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Clusterin
type: ProteinReference
xref: PTHR10970:SF1
xref: uniprot P10909 133
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re38 809
type: Stoichiometry
physical entity: IkB kinase complex
stoichiometric coefficient: 1.0

HuR
type: ProteinReference
xref: P07211
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.HuR
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: ELAV-like protein 1

DISSOCIATION_LEFT__E_cadherin_beta_catenin-RIGHT__E_cadherin-_beta_catenin-_re362
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re362 517
participant stoichiometry: PARTICIPANT STOICHIOMETRY re362 515
participant stoichiometry: PARTICIPANT STOICHIOMETRY re362 516
left: E-cadherin/beta-catenin
interaction type: DISSOCIATION
right: beta-catenin
right: E-cadherin

Pi
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=ION

TRANSCRIPTION_LEFT__GCG-RIGHT__GCG-_re466
type: TemplateReaction
product: GCG
xref: TRANSCRIPTION
participant: GCG
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

SOS1
type: Protein
entity reference: SOS1
feature: COMPLEX PARTICIPANT BINDING FEATURE s946 sa273 266
feature: ACTIVE 13
feature: S SOS1 s946 sa273 rs2
feature: T SOS1 s946 sa273 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR10505:SF14
type: RelationshipXref
id: PTHR10505:SF14
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__uPA-RIGHT__uPA-_re624
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re624 786
participant stoichiometry: PARTICIPANT STOICHIOMETRY re624 785
left: uPA
interaction type: TRANSPORT
right: uPA

STATE_TRANSITION_LEFT__PAK1-RIGHT__PAK1-_re82
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re82 604
participant stoichiometry: PARTICIPANT STOICHIOMETRY re82 605
left: PAK1
interaction type: STATE_TRANSITION
right: PAK1

STATE_TRANSITION_LEFT__PAK1-RIGHT__PAK1-_re81
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re81 606
participant stoichiometry: PARTICIPANT STOICHIOMETRY re81 607
left: PAK1
interaction type: STATE_TRANSITION
right: PAK1

STATE_TRANSITION_LEFT__IRS1-RIGHT__IRS1-_re99
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re99 577
participant stoichiometry: PARTICIPANT STOICHIOMETRY re99 578
left: IRS1
interaction type: STATE_TRANSITION
right: IRS1

STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re411
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re411 1208
participant stoichiometry: PARTICIPANT STOICHIOMETRY re411 1209
left: RAF1
interaction type: STATE_TRANSITION
right: RAF1

Y1101 EGFR s727 sa266 rs10
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y1101
feature location: Y1101 EGFR s727 sa266 rs10 Y1101
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=6.130593664005225
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y1101

STATE_TRANSITION_LEFT__RAF1-RIGHT__RAF1-_re410
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re410 1212
participant stoichiometry: PARTICIPANT STOICHIOMETRY re410 1213
left: RAF1
interaction type: STATE_TRANSITION
right: RAF1

Ca2 PLUS s2013 sa1010 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot P48730 75
type: UnificationXref
id: P48730
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HRAS_GDP-_GTP-RIGHT__HRAS_GTP-_GDP-_re156
controller: PKCepsilon

mTOR
type: Protein
feature: S1261 mTOR s924 sa308 rs1
feature: ACTIVE 13
feature: S2481 mTOR s924 sa308 rs2
feature: T2446 mTOR s924 sa308 rs4
feature: S2448 mTOR s924 sa308 rs3
feature: COMPLEX PARTICIPANT BINDING FEATURE s924 sa308 182
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

T538 PKCtheta s1720 sa643 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T538
feature location: T538 PKCtheta s1720 sa643 rs1 T538
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T538
comment: MODIFICATION_RESIDUE_ANGLE=2.34

PARTICIPANT STOICHIOMETRY re580 823
type: Stoichiometry
physical entity: BAD/BCL2L1 heterodimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re580 822
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re580 821
type: Stoichiometry
physical entity: BCL2L1
stoichiometric coefficient: 1.0

SP1
type: Protein
entity reference: SP1
feature: ACTIVE 13
feature: SP1 s1287 sa346 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

GRB2 @EGFR s887 sa277 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GRB2 @EGFR
stoichiometric coefficient: 1.0

uniprot O43474 112
type: UnificationXref
id: O43474
db: uniprot

PARTICIPANT STOICHIOMETRY re597 755
type: Stoichiometry
physical entity: GAS-REBP2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re597 756
type: Stoichiometry
physical entity: GAS REBP2 s1639 sa917
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FAK1-RIGHT__FAK1-_re69
controller: FAK1

HDAC7
type: ProteinReference
xref: P07235
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.HDAC7
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Histone deacetylase 7

MAP2K6
type: ProteinReference
xref: P07233
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAP2K6
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dual specificity mitogen-activated protein kinase kinase 6

FAK1
type: Protein
entity reference: FAK1
feature: Y407 FAK1 s668 sa118 rs2
feature: Y861 FAK1 s668 sa118 rs5
feature: Y576 FAK1 s668 sa118 rs3
feature: Y397 FAK1 s668 sa118 rs1
feature: Y925 FAK1 s668 sa118 rs6
feature: Y577 FAK1 s668 sa118 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

AKT1 s908 sa303 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: AKT1
stoichiometric coefficient: 1.0

CAS-CRK complex
type: Complex
component stoichiometry: CAS s766 sa287 STOICHIOMETRY ID COMPLEX
component stoichiometry: CRK s772 sa288 STOICHIOMETRY ID COMPLEX
component: CAS
component: CRK s772 sa288
feature: COMPLEX BINDING FEATURE s1948 csa15 349
feature: COMPLEX BINDING FEATURE s1948 csa15 351
cellular location: CELL

T308 AKT1 s913 sa301 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T308
feature location: T308 AKT1 s913 sa301 rs1 T308
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T308
comment: MODIFICATION_RESIDUE_ANGLE=0.8191115980742862

KNOWN_TRANSITION_OMITTED_LEFT__CCK_8-RIGHT__CCK-_re493
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re493 1023
participant stoichiometry: PARTICIPANT STOICHIOMETRY re493 1024
left: CCK-8
interaction type: KNOWN_TRANSITION_OMITTED
right: CCK

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RHOA_GTP-RIGHT__Pi-_RHOA_GDP-_re75
controller: ARHGAP4

S NFAT1 s2015 sa1013 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S NFAT1 s2015 sa1013 rs1 S
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8365926382770912

T439 CCK2R s1660 sa22 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T439
feature location: T439 CCK2R s1660 sa22 rs6 T439
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.751588888718252
comment: MODIFICATION_RESIDUE_NAME=T439

Y580 FAK2 s1591 sa878 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y580
feature location: Y580 FAK2 s1591 sa878 rs3 Y580
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y580
comment: MODIFICATION_RESIDUE_ANGLE=0.75

Y762 CAS s764 sa117 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y762
feature location: Y762 CAS s764 sa117 rs1 Y762
comment: MODIFICATION_RESIDUE_ANGLE=5.480462184295429
comment: MODIFICATION_RESIDUE_NAME=Y762
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

YES1
type: Protein
entity reference: YES1
feature: Y416 YES1 s1609 sa890 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

p62 SRC
type: ProteinReference
xref: P07047
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p62 SRC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Proto-oncogene tyrosine-protein kinase Src

STATE_TRANSITION_LEFT__STAT3-RIGHT__STAT3-_re179
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re179 855
participant stoichiometry: PARTICIPANT STOICHIOMETRY re179 854
left: STAT3
interaction type: STATE_TRANSITION
right: STAT3

PARTICIPANT STOICHIOMETRY re380 1197
type: Stoichiometry
physical entity: PKCbeta
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__PAI2-RIGHT__PAI2-_re225
type: TemplateReaction
product: PAI2
xref: TRANSCRIPTION
participant: PAI2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

TRANSPORT_LEFT__ATF2-RIGHT__ATF2-_re465
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re465 1126
participant stoichiometry: PARTICIPANT STOICHIOMETRY re465 1125
left: ATF2
interaction type: TRANSPORT
right: ATF2

BAD s1615 sa893 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

uniprot P12830 86
type: UnificationXref
id: P12830
db: uniprot

PDE
type: ProteinReference
xref: P07161
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PDE
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

STATE_TRANSITION_LEFT__TAK1-RIGHT__TAK1-_re36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 817
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 818
left: TAK1
interaction type: STATE_TRANSITION
right: TAK1

STATE_TRANSITION_LEFT__LYN-RIGHT__LYN-_re637
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re637 734
participant stoichiometry: PARTICIPANT STOICHIOMETRY re637 733
left: LYN
interaction type: STATE_TRANSITION
right: LYN

PARTICIPANT STOICHIOMETRY re665 623
type: Stoichiometry
physical entity: Ca_CaM
stoichiometric coefficient: 1.0

MMP9
type: DnaRegionReference
member entity reference: Matrix metalloproteinase-9
xref: G07288
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.MMP9
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re380 1198
type: Stoichiometry
physical entity: PKCbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re450 1159
type: Stoichiometry
physical entity: AP1 (FOS+JUN)
stoichiometric coefficient: 1.0

HuR
type: RnaRegion
entity reference: HuR
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re450 1158
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re450 1157
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PKCeta-RIGHT__PKCeta-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 922
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 923
left: PKCeta
interaction type: STATE_TRANSITION
right: PKCeta

PARTICIPANT STOICHIOMETRY re665 621
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re665 622
type: Stoichiometry
physical entity: CaM
stoichiometric coefficient: 1.0

SP1
type: Protein
entity reference: SP1
feature: SP1 s1694 sa344 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

SAP1
type: Protein
entity reference: SAP1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

S259 RAF1 s156 sa686 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S259
feature location: S259 RAF1 s156 sa686 rs3 S259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S259
comment: MODIFICATION_RESIDUE_ANGLE=2.328231397687482

HDC
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.HDC
comment: ENTITY_REFERENCE_NOTES=

T491 RAF1 s154 sa685 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T491
feature location: T491 RAF1 s154 sa685 rs4 T491
comment: MODIFICATION_RESIDUE_NAME=T491
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.3986264000533355

STATE_TRANSITION_LEFT__PRKD2-RIGHT__PRKD2-_re446
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re446 1165
participant stoichiometry: PARTICIPANT STOICHIOMETRY re446 1164
left: PRKD2
interaction type: STATE_TRANSITION
right: PRKD2

HDC
type: DnaRegion
entity reference: HDC
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

MCL1
type: DnaRegion
entity reference: MCL1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Y472 PLCgamma1 s1622 sa903 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y472
feature location: Y472 PLCgamma1 s1622 sa903 rs1 Y472
comment: MODIFICATION_RESIDUE_NAME=Y472
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8080320590199856

Cytochrome C
type: SmallMolecule
cellular location: Mitochondria
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re530 1016
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re530 1015
type: Stoichiometry
physical entity: c-RAF / RAF1
stoichiometric coefficient: 1.0

NFKB1 p50 s1681 sa327 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NFKB1 (p50)
stoichiometric coefficient: 1.0

DISSOCIATION
type: RelationshipTypeVocabulary

SNAI1
type: Protein
entity reference: SNAI1
feature: S246 SNAI1 s54 sa197 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PTHR19850:SF29
type: RelationshipXref
id: PTHR19850:SF29
db: PANTHER Family
relationship type: By Homology

CXCL1
type: RnaRegion
entity reference: CXCL1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

Y725 STAT3 s674 sa181 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y725
feature location: Y725 STAT3 s674 sa181 rs2 Y725
comment: MODIFICATION_RESIDUE_ANGLE=5.583002134385839
comment: MODIFICATION_RESIDUE_NAME=Y725
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

STATE_TRANSITION_LEFT__Galpha_q_complex-RIGHT__LARG-_re531
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re531 1012
participant stoichiometry: PARTICIPANT STOICHIOMETRY re531 1011
left: Galpha q complex
interaction type: STATE_TRANSITION
right: LARG

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Preprogastrin_@ER-RIGHT__Progastrin_@ER___Golgi-_re42
controller: Signal peptidase

SOS1 s890 sa281 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS1
stoichiometric coefficient: 1.0

PTHR44329:SF55
type: RelationshipXref
id: PTHR44329:SF55
db: PANTHER Family
relationship type: By Homology

TACR1
type: DnaRegion
entity reference: TACR1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY re447 1163
type: Stoichiometry
physical entity: HDAC7
stoichiometric coefficient: 1.0

Signal peptidase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re447 1162
type: Stoichiometry
physical entity: HDAC7
stoichiometric coefficient: 1.0

SOS1
type: Protein
entity reference: SOS1
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s894 sa270 344
feature: S SOS1 s894 sa270 rs2
feature: T SOS1 s894 sa270 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

EGR1 s1799 sa963 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.7383466605211034

STATE_TRANSITION_LEFT__c_RAF___RAF1-RIGHT__c_RAF___RAF1-_re173
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re173 872
participant stoichiometry: PARTICIPANT STOICHIOMETRY re173 873
left: c-RAF / RAF1
interaction type: STATE_TRANSITION
right: c-RAF / RAF1

IRS1 s933 sa295 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IRS1
stoichiometric coefficient: 1.0

mLST8 s916 sa317 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mLST8
stoichiometric coefficient: 1.0

PTHR11482:SF42
type: RelationshipXref
id: PTHR11482:SF42
db: PANTHER Family
relationship type: By Homology

GRB2 s948 sa280 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

PTHR44329:SF46
type: RelationshipXref
id: PTHR44329:SF46
db: PANTHER Family
relationship type: By Homology

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__RYR1_2_3-RIGHT__RYR1_2_3-_re515
control type: INHIBITION
controller: AA

active CCK2R/Beta-arrestin complex
type: Complex
component stoichiometry: Beta arrestin 1 2 s1412 sa570 STOICHIOMETRY ID COMPLEX
component stoichiometry: CCK2R s1410 sa568 STOICHIOMETRY ID COMPLEX
component stoichiometry: G17 s1411 sa569 STOICHIOMETRY ID COMPLEX
component: Beta-arrestin-1/2
component: CCK2R
component: G17
feature: COMPLEX BINDING FEATURE s1930 csa55 225
feature: COMPLEX BINDING FEATURE s1930 csa55 229
feature: COMPLEX BINDING FEATURE s1930 csa55 227
cellular location: Endosome

PTHR44329:SF47
type: RelationshipXref
id: PTHR44329:SF47
db: PANTHER Family
relationship type: By Homology

DISSOCIATION_LEFT__BAD_BCL2_heterodimer-RIGHT__BAD-_BCL2-_re577
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re577 843
participant stoichiometry: PARTICIPANT STOICHIOMETRY re577 845
participant stoichiometry: PARTICIPANT STOICHIOMETRY re577 844
left: BAD/BCL2 heterodimer
interaction type: DISSOCIATION
right: BCL2
right: BAD

HBEGF s874 sa267 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HBEGF
stoichiometric coefficient: 1.0

Adapter molecule crk
type: ProteinReference
xref: uniprot P46108 105
organism: Homo sapiens

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Gastric mucosa differentiation
controller: REG1A

c-RAF/14-3-3 complex
type: Complex
component stoichiometry: RAF1 s1336 sa692 STOICHIOMETRY ID COMPLEX
component stoichiometry: 14 3 3 beta alpha s1334 sa690 STOICHIOMETRY ID COMPLEX
component: RAF1
component: 14-3-3 beta/alpha
feature: COMPLEX BINDING FEATURE s1954 csa60 297
feature: COMPLEX BINDING FEATURE s1954 csa60 295
cellular location: RAF1 c11

Y185 MAPK8 10 s692 sa223 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y185
feature location: Y185 MAPK8 10 s692 sa223 rs2 Y185
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y185
comment: MODIFICATION_RESIDUE_ANGLE=5.55783770758315

Wortmannin
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=DRUG

FOS
type: DnaRegionReference
member entity reference: HGNC 3796
xref: G07266
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.FOS
comment: ENTITY_REFERENCE_NOTES=

S748 PRKD1 s660 sa42 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S748
feature location: S748 PRKD1 s660 sa42 rs2 S748
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S748
comment: MODIFICATION_RESIDUE_ANGLE=5.553194421623227

CRK
type: Protein
entity reference: CRK
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR10654:SF15
type: RelationshipXref
id: PTHR10654:SF15
db: PANTHER Family
relationship type: By Homology

MAPKAP1 s962 sa319 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAPKAP1
stoichiometric coefficient: 1.0

Calcitonin
type: DnaReference
xref: PTHR10505:SF14
organism: Homo sapiens

CXCL1
type: DnaRegion
entity reference: CXCL1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

STATE_TRANSITION_LEFT__MAP2K1-RIGHT__MAP2K1-_re140
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re140 992
participant stoichiometry: PARTICIPANT STOICHIOMETRY re140 991
left: MAP2K1
interaction type: STATE_TRANSITION
right: MAP2K1

PARTICIPANT STOICHIOMETRY re615 828
type: Stoichiometry
physical entity: NFKB1/RELA heterodimer
stoichiometric coefficient: 1.0

BAX s1567 sa967 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 2.0

Paxillin
type: ProteinReference
xref: PTHR24216:SF11
xref: uniprot P49023 123
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re615 829
type: Stoichiometry
physical entity: BIRC3
stoichiometric coefficient: 1.0

S374 FOS s205 sa337 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S374
feature location: S374 FOS s205 sa337 rs6 S374
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=1.5878173396239432
comment: MODIFICATION_RESIDUE_NAME=S374

B-Raf
type: ProteinReference
xref: P07057
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.B-Raf
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Serine/threonine-protein kinase B-raf

STATE_TRANSITION_LEFT__PRKD2-RIGHT__PRKD2-_re416
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re416 1201
participant stoichiometry: PARTICIPANT STOICHIOMETRY re416 1202
left: PRKD2
interaction type: STATE_TRANSITION
right: PRKD2

Y764 CAS s764 sa117 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y764
feature location: Y764 CAS s764 sa117 rs2 Y764
comment: MODIFICATION_RESIDUE_NAME=Y764
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7892481543944946

S434 CCK2R s1688 sa565 rs12
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S434
feature location: S434 CCK2R s1688 sa565 rs12 S434
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.078526462630984
comment: MODIFICATION_RESIDUE_NAME=S434

ITGAV
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.ITGAV
comment: ENTITY_REFERENCE_NOTES=

G17 - Gly
type: ProteinReference
xref: P07236
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.G17 - Gly
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Gastrin

T SOS1 s744 sa110 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T SOS1 s744 sa110 rs1 T
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_ANGLE=0.8611146530060259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

beta-catenin
type: Protein
entity reference: beta-catenin
feature: T41 beta catenin s1862 sa635 rs4
feature: S45 beta catenin s1862 sa635 rs3
feature: S33 beta catenin s1862 sa635 rs2
feature: S37 beta catenin s1862 sa635 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y881 FAK2 s1892 sa975 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y881
feature location: Y881 FAK2 s1892 sa975 rs4 Y881
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5
comment: MODIFICATION_RESIDUE_NAME=Y881

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__TFF1-RIGHT__TFF1-_re244
controller: SP3

S NFAT1 s2016 sa1012 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S NFAT1 s2016 sa1012 rs1 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8365926382770912

PARTICIPANT STOICHIOMETRY re299 556
type: Stoichiometry
physical entity: s785
stoichiometric coefficient: 1.0

SAP1
type: Protein
entity reference: SAP1
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re299 555
type: Stoichiometry
physical entity: cAMP s1840 sa472
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PI4,5_P2-RIGHT__DAG-_IP3-_re2
controller: PLCgamma1 s716 sa18

PARTICIPANT STOICHIOMETRY re651 670
type: Stoichiometry
physical entity: FOXO3
stoichiometric coefficient: 1.0

BIRC2
type: DnaRegionReference
member entity reference: Baculoviral IAP repeat-containing protein 2
xref: G07278
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.BIRC2
comment: ENTITY_REFERENCE_NOTES=

uniprot P37231 171
type: UnificationXref
id: P37231
db: uniprot

S ROCK1 s787 sa138 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S ROCK1 s787 sa138 rs1 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.632426828935986

MMP9
type: RnaRegion
entity reference: MMP9
cellular location: CELL
comment: SPECIES_TYPE=RNA

NADP
type: SmallMolecule
cellular location: Lysosome
comment: SPECIES_TYPE=SIMPLE_MOLECULE

E-cadherin
type: DnaRegionReference
member entity reference: Cadherin-1
xref: G07274
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.E-cadherin
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re416 1202
type: Stoichiometry
physical entity: PRKD2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re416 1201
type: Stoichiometry
physical entity: PRKD2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CD38-RIGHT__CD38-_re356
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re356 527
participant stoichiometry: PARTICIPANT STOICHIOMETRY re356 526
left: CD38
interaction type: STATE_TRANSITION
right: CD38

PARTICIPANT STOICHIOMETRY re143 985
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re143 986
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 2.0

EGR1
type: Protein
entity reference: EGR1
feature: ACTIVE 13
feature: EGR1 s1799 sa963 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Krueppel-like factor 4
type: ProteinReference
xref: PTHR23235:SF41
xref: uniprot O43474 112
organism: Homo sapiens

Pro-caspase-3
type: ProteinReference
xref: P07231
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Pro-caspase-3
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Caspase-3

MCL1
type: DnaRegionReference
member entity reference: Induced myeloid leukemia cell differentiation protein Mcl-1
xref: G07275
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.MCL1
comment: ENTITY_REFERENCE_NOTES=

Galpha q s686 sa248 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galpha q
stoichiometric coefficient: 1.0

CNKSR1
type: Protein
entity reference: CNKSR1
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

P07209
type: UnificationXref
id: P07209
db: PANTHER Pathway Component

T41 beta catenin s1315 sa638 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T41
feature location: T41 beta catenin s1315 sa638 rs4 T41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T41
comment: MODIFICATION_RESIDUE_ANGLE=2.3739822534748654

P07214
type: UnificationXref
id: P07214
db: PANTHER Pathway Component

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Regeneration hypoplasia
controller: NO

P07215
type: UnificationXref
id: P07215
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re491 1027
type: Stoichiometry
physical entity: CCK-33
stoichiometric coefficient: 1.0

P07212
type: UnificationXref
id: P07212
db: PANTHER Pathway Component

KNOWN_TRANSITION_OMITTED_LEFT__RAF-RIGHT__A_Raf-_re383
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re383 1194
participant stoichiometry: PARTICIPANT STOICHIOMETRY re383 1193
left: RAF
interaction type: KNOWN_TRANSITION_OMITTED
right: A-Raf

PARTICIPANT STOICHIOMETRY re491 1028
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

P07213
type: UnificationXref
id: P07213
db: PANTHER Pathway Component

Bcl2-associated agonist of cell death
type: ProteinReference
xref: PTHR28540:SF1
xref: uniprot Q92934 95
organism: Homo sapiens

P07218
type: UnificationXref
id: P07218
db: PANTHER Pathway Component

T202 MAPK3 s989 sa208 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T202
feature location: T202 MAPK3 s989 sa208 rs1 T202
comment: MODIFICATION_RESIDUE_ANGLE=0.79
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T202

P07216
type: UnificationXref
id: P07216
db: PANTHER Pathway Component

P07217
type: UnificationXref
id: P07217
db: PANTHER Pathway Component

PTHR12305:SF81
type: RelationshipXref
id: PTHR12305:SF81
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPKAP_K2-RIGHT__MAPKAP_K2-_re573
controller: p38MAPK s998 sa227

P07210
type: UnificationXref
id: P07210
db: PANTHER Pathway Component

P07211
type: UnificationXref
id: P07211
db: PANTHER Pathway Component

S SOS1 s749 sa276 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S SOS1 s749 sa276 rs2 S
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.511144255404544

S136 BAD s1561 sa290 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S136
feature location: S136 BAD s1561 sa290 rs2 S136
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8079058030724882
comment: MODIFICATION_RESIDUE_NAME=S136

TRANSLATION_LEFT__CLU-RIGHT__CLU-_re570
type: TemplateReaction
product: CLU
xref: TRANSLATION
participant: CLU
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

cADPR
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

G34-Gly
type: ProteinReference
xref: P07036
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.G34-Gly
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Gastrin

PARTICIPANT STOICHIOMETRY re355 528
type: Stoichiometry
physical entity: NOS1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re355 529
type: Stoichiometry
physical entity: NOS1
stoichiometric coefficient: 1.0

p190RhoGEF
type: Protein
entity reference: p190RhoGEF
feature: COMPLEX PARTICIPANT BINDING FEATURE s1453 sa785 404
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

P07202
type: UnificationXref
id: P07202
db: PANTHER Pathway Component

P07203
type: UnificationXref
id: P07203
db: PANTHER Pathway Component

MAP3K11
type: ProteinReference
xref: P07139
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAP3K11
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mitogen-activated protein kinase kinase kinase 11

P07204
type: UnificationXref
id: P07204
db: PANTHER Pathway Component

uniprot Q92667 81
type: UnificationXref
id: Q92667
db: uniprot

CCK1R
type: Protein
feature: S264 CCK1R s866 sa458 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s866 sa458 444
feature: S260 CCK1R s866 sa458 rs1
feature: S430 CCK1R s866 sa458 rs4
feature: S307 CCK1R s866 sa458 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

P07206
type: UnificationXref
id: P07206
db: PANTHER Pathway Component

P07207
type: UnificationXref
id: P07207
db: PANTHER Pathway Component

uniprot Q02750 17
type: UnificationXref
id: Q02750
db: uniprot

RELA (p65)
type: Protein
feature: RELA p65 s1682 sa328 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1682 sa328 286
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re250 690
type: Stoichiometry
physical entity: TFF2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re250 691
type: Stoichiometry
physical entity: TFF2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CETP-RIGHT__CETP-_re468
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re468 1117
participant stoichiometry: PARTICIPANT STOICHIOMETRY re468 1116
left: CETP
interaction type: STATE_TRANSITION
right: CETP

STATE_TRANSITION_LEFT__cGK_1-RIGHT__cGK_1-_re359
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re359 520
participant stoichiometry: PARTICIPANT STOICHIOMETRY re359 521
left: cGK 1
interaction type: STATE_TRANSITION
right: cGK 1

GalphaS
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1185 sa492 394
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re596 758
type: Stoichiometry
physical entity: GAS-REBP1
stoichiometric coefficient: 1.0

S9 GSK3beta s978 sa198 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S9
feature location: S9 GSK3beta s978 sa198 rs1 S9
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S9
comment: MODIFICATION_RESIDUE_ANGLE=0.7039197825007742

PARTICIPANT STOICHIOMETRY re336 546
type: Stoichiometry
physical entity: active CCK2R/Beta-arrestin complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re336 548
type: Stoichiometry
physical entity: CCK2R
stoichiometric coefficient: 1.0

14-3-3 beta/alpha
type: Protein
entity reference: 14-3-3 beta/alpha
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re336 547
type: Stoichiometry
physical entity: G17
stoichiometric coefficient: 1.0

G17
type: Protein
entity reference: G17
feature: ACTIVE 13
feature: Y G17 s17 sa89 rs1
comment: SPECIES_TYPE=PROTEIN

S222 MAP2K1 s821 sa207 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S222
feature location: S222 MAP2K1 s821 sa207 rs2 S222
comment: MODIFICATION_RESIDUE_ANGLE=0.7629582158718069
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S222

JAK2
type: Protein
entity reference: JAK2
feature: Y972 JAK2 s1634 sa152 rs3
feature: ACTIVE 13
feature: Y966 JAK2 s1634 sa152 rs2
feature: Y868 JAK2 s1634 sa152 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y239 240 p46 SHC1 s1781 sa103 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y239 240
feature location: Y239 240 p46 SHC1 s1781 sa103 rs2 Y239 240
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y239/240
comment: MODIFICATION_RESIDUE_ANGLE=2.3695516018147504

uniprot Q13469 162
type: UnificationXref
id: Q13469
db: uniprot

STATE_TRANSITION_LEFT__Adenylate_cyclase-RIGHT__Adenylate_cyclase-_re294
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re294 562
participant stoichiometry: PARTICIPANT STOICHIOMETRY re294 563
left: Adenylate cyclase
interaction type: STATE_TRANSITION
right: Adenylate cyclase

ROCK1
type: ProteinReference
xref: P07033
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.ROCK1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Rho-associated protein kinase 1

PARTICIPANT STOICHIOMETRY re27 853
type: Stoichiometry
physical entity: PRKD1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRKD2-RIGHT__PRKD2-_re416
controller: PKCalpha

PARTICIPANT STOICHIOMETRY re27 852
type: Stoichiometry
physical entity: PRKD1
stoichiometric coefficient: 1.0

S719 RPTOR s954 sa309 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S719
feature location: S719 RPTOR s954 sa309 rs1 S719
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S719
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.6768177721443449

CCK-GRR
type: Protein
entity reference: CCK-GRR
feature: Y94 CCK GRR s877 sa501 rs3
feature: Y77 CCK GRR s877 sa501 rs1
feature: Y91 CCK GRR s877 sa501 rs2
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PPARgamma-RIGHT__s1447-_re484
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re484 1058
participant stoichiometry: PARTICIPANT STOICHIOMETRY re484 1057
left: PPARgamma
interaction type: STATE_TRANSITION
right: s1447

PARTICIPANT STOICHIOMETRY re596 757
type: Stoichiometry
physical entity: GAS-REBP1
stoichiometric coefficient: 1.0

BIRC3
type: DnaRegionReference
member entity reference: Baculoviral IAP repeat-containing protein 3
xref: G07286
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.BIRC3
comment: ENTITY_REFERENCE_NOTES=

I441 CCK2R s1688 sa565 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY I441
feature location: I441 CCK2R s1688 sa565 rs9 I441
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.567911979799767
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=I441

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SP3-RIGHT__SP3-_re196
controller: MAPK1/3

Y204 MAPK3 s989 sa208 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y204
feature location: Y204 MAPK3 s989 sa208 rs2 Y204
comment: MODIFICATION_RESIDUE_ANGLE=5.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y204

PARTICIPANT STOICHIOMETRY re562 900
type: Stoichiometry
physical entity: BAD/BCL2 heterodimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re195 780
type: Stoichiometry
physical entity: SP1
stoichiometric coefficient: 1.0

NFKB1 p50 s1880 sa971 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.78837880158871
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

BCL2
type: Protein
entity reference: BCL2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1562 sa856 240
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re370 483
type: Stoichiometry
physical entity: E-cadherin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re370 484
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re370 485
type: Stoichiometry
physical entity: E-cadherin/beta-catenin
stoichiometric coefficient: 1.0

FOXO3
type: Protein
entity reference: FOXO3
feature: S315 FOXO3 s1621 sa901 rs1
feature: ACTIVE 13
feature: S253 FOXO3 s1621 sa901 rs2
feature: T32 FOXO3 s1621 sa901 rs3
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

MEF2B
type: Protein
entity reference: MEF2B
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re195 779
type: Stoichiometry
physical entity: SP1
stoichiometric coefficient: 1.0

Adenylate cyclase type 1
type: ProteinReference
xref: uniprot Q08828 57
xref: PTHR45627:SF12
organism: Homo sapiens

Calcium/calmodulin-dependent protein kinase kinase 1
type: ProteinReference
xref: uniprot Q8N5S9 56
xref: PTHR24346:SF39
organism: Homo sapiens

Y527 SRC @Galphaq s1782 sa950 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 SRC @Galphaq s1782 sa950 rs2 Y527
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.585857905576321
comment: MODIFICATION_RESIDUE_NAME=Y527

S494 RAF1 s154 sa685 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S494
feature location: S494 RAF1 s154 sa685 rs5 S494
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.018263774283071
comment: MODIFICATION_RESIDUE_NAME=S494

Y341 RAF1 s155 sa679 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y341
feature location: Y341 RAF1 s155 sa679 rs2 Y341
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y341
comment: MODIFICATION_RESIDUE_ANGLE=0.813361255902311

COX2
type: ProteinReference
xref: P07080
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.COX2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Prostaglandin G/H synthase 2

STATE_TRANSITION_LEFT__RHEB_GDP-RIGHT__RHEB_GTP-_re113
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 1098
participant stoichiometry: PARTICIPANT STOICHIOMETRY re113 1097
left: RHEB-GDP
interaction type: STATE_TRANSITION
right: RHEB-GTP

S494 RAF1 s156 sa686 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S494
feature location: S494 RAF1 s156 sa686 rs5 S494
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.018263774283071
comment: MODIFICATION_RESIDUE_NAME=S494

MAPK7
type: Protein
entity reference: MAPK7
feature: T219 MAPK7 s471 sa232 rs1
feature: Y221 MAPK7 s471 sa232 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S315 FOXO3 s1991 sa995 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S315
feature location: S315 FOXO3 s1991 sa995 rs1 S315
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S315
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.71

P07233
type: UnificationXref
id: P07233
db: PANTHER Pathway Component

P07232
type: UnificationXref
id: P07232
db: PANTHER Pathway Component

S45 beta catenin s1852 sa183 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S45
feature location: S45 beta catenin s1852 sa183 rs3 S45
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S45
comment: MODIFICATION_RESIDUE_ANGLE=3.845512436090568

P07231
type: UnificationXref
id: P07231
db: PANTHER Pathway Component

Pro-CCK @ secretory granule
type: Protein
entity reference: Pro-CCK @ secretory granule
feature: Y94 Pro CCK @ secretory granule s1192 sa500 rs3
feature: Y91 Pro CCK @ secretory granule s1192 sa500 rs2
feature: Y77 Pro CCK @ secretory granule s1192 sa500 rs1
comment: SPECIES_TYPE=PROTEIN

P07230
type: UnificationXref
id: P07230
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRKD1-RIGHT__PRKD1-_re27
controller: PKCdelta

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Complex__GRB2_SOS1_-RIGHT__Complex__GRB2_SOS1_-_re65
controller: Complex (HBEGF/EGFR)

P07237
type: UnificationXref
id: P07237
db: PANTHER Pathway Component

P07236
type: UnificationXref
id: P07236
db: PANTHER Pathway Component

P07235
type: UnificationXref
id: P07235
db: PANTHER Pathway Component

S181 HDAC7 s1821 sa739 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S181
feature location: S181 HDAC7 s1821 sa739 rs1 S181
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S181
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7963402430732642

STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_re70
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re70 665
participant stoichiometry: PARTICIPANT STOICHIOMETRY re70 666
left: Paxillin
interaction type: STATE_TRANSITION
right: Paxillin

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__VMAT2-RIGHT__VMAT2-_re233
controller: SP1

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RHOA_GDP-_GTP-RIGHT__GDP-_RHOA_GTP-_re74
controller: Galpha13

P07220
type: UnificationXref
id: P07220
db: PANTHER Pathway Component

P07222
type: UnificationXref
id: P07222
db: PANTHER Pathway Component

P07221
type: UnificationXref
id: P07221
db: PANTHER Pathway Component

Y416 p60 SRC s963 sa286 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 p60 SRC s963 sa286 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.8018247916515125

PKA-R1
type: Complex
component stoichiometry: cAMP s1532 sa838 STOICHIOMETRY ID COMPLEX
component stoichiometry: PKA R1alpha beta s1531 sa837 STOICHIOMETRY ID COMPLEX
component: PKA-R1alpha/beta
component: cAMP
feature: COMPLEX BINDING FEATURE s1957 csa67 477
feature: COMPLEX BINDING FEATURE s1957 csa67 475
cellular location: CELL

P07228
type: UnificationXref
id: P07228
db: PANTHER Pathway Component

S32 FOS s205 sa337 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S32
feature location: S32 FOS s205 sa337 rs2 S32
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S32
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.845512436090568

P07227
type: UnificationXref
id: P07227
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re515 1079
type: Stoichiometry
physical entity: RYR1/2/3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re515 1078
type: Stoichiometry
physical entity: RYR1/2/3
stoichiometric coefficient: 1.0

P07224
type: UnificationXref
id: P07224
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLCgamma1-RIGHT__PLCgamma1-_re583
controller: p60 SRC

P07223
type: UnificationXref
id: P07223
db: PANTHER Pathway Component

P07226
type: UnificationXref
id: P07226
db: PANTHER Pathway Component

P07225
type: UnificationXref
id: P07225
db: PANTHER Pathway Component

Y762 CAS s765 sa116 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y762
feature location: Y762 CAS s765 sa116 rs1 Y762
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.480462184295429
comment: MODIFICATION_RESIDUE_NAME=Y762
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

S710 PRKD2 s774 sa735 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S710
feature location: S710 PRKD2 s774 sa735 rs3 S710
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3074279375630917
comment: MODIFICATION_RESIDUE_NAME=S710

BAX/BCL2 heterodimer
type: Complex
component stoichiometry: BCL2 s808 sa294 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 91STOICHIOMETRY ID COMPLEX
component: BCL2
component: BAX
feature: COMPLEX BINDING FEATURE s1964 csa18 245
feature: COMPLEX BINDING FEATURE s1964 csa18 243
cellular location: Mitochondria

CAS
type: Protein
entity reference: CAS
feature: Y762 CAS s766 sa287 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s766 sa287 350
feature: Y764 CAS s766 sa287 rs2
feature: Y332 CAS s766 sa287 rs3
feature: Y460 CAS s766 sa287 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

uniprot P49023 123
type: UnificationXref
id: P49023
db: uniprot

PARTICIPANT STOICHIOMETRY re407 499
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAP2K1-RIGHT__MAP2K1-_re140
controller: RAF1

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re3
control type: ACTIVATION
controller: Glucose

PTHR46680:SF1
type: RelationshipXref
id: PTHR46680:SF1
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__PI3K_Class_I-_re101
controller: FAK1-SRC complex

RAF1
type: Protein
entity reference: RAF1
feature: S497 9 RAF1 s1336 sa692 rs8
feature: T491 RAF1 s1336 sa692 rs4
feature: S621 RAF1 s1336 sa692 rs9
feature: Y341 RAF1 s1336 sa692 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1336 sa692 298
feature: S494 RAF1 s1336 sa692 rs5
feature: S43 RAF1 s1336 sa692 rs6
feature: S259 RAF1 s1336 sa692 rs3
feature: T268 9 RAF1 s1336 sa692 rs7
feature: S338 RAF1 s1336 sa692 rs1
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pre_pro_CCK_@_ER-RIGHT__Pro_CCK_@_TGN-_re302
controller: Protein tyrosine sulfotransferase

Transcription factor 4
type: ProteinReference
xref: PTHR11793:SF10
xref: uniprot P15884 164
organism: Homo sapiens

REG1A
type: RnaRegion
entity reference: REG1A
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATF2-RIGHT__ATF2-_re460
controller: p38MAPK s998 sa227

CAS
type: Protein
entity reference: CAS
feature: Y332 CAS s765 sa116 rs3
feature: Y764 CAS s765 sa116 rs2
feature: Y762 CAS s765 sa116 rs1
feature: Y460 CAS s765 sa116 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

T SOS1 s894 sa270 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T SOS1 s894 sa270 rs1 T
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_ANGLE=0.8611146530060259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RAC1_GTP-RIGHT__Pi-_RAC1_GDP-_re77
controller: RGS2

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re351
controller: TPC1/2

PKA R1alpha beta s1519 sa829 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKA-R1alpha/beta
stoichiometric coefficient: 1.0

GalphaS
type: Complex
component stoichiometry: GalphaS s1182 sa490 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s1183 sa491 STOICHIOMETRY ID COMPLEX
component: GalphaS
component: GTP
feature: COMPLEX BINDING FEATURE s738 csa46 299
feature: COMPLEX BINDING FEATURE s738 csa46 301
cellular location: CELL

FAK2-SRC-GRB2 complex
type: Complex
component stoichiometry: GRB2 s1607 sa888 STOICHIOMETRY ID COMPLEX
component stoichiometry: FAK2 s1598 sa886 STOICHIOMETRY ID COMPLEX
component stoichiometry: SRC @Galphaq s1599 sa887 STOICHIOMETRY ID COMPLEX
component: GRB2
component: SRC @Galphaq
component: FAK2
feature: COMPLEX BINDING FEATURE s1951 csa73 439
feature: COMPLEX BINDING FEATURE s1951 csa73 437
feature: COMPLEX BINDING FEATURE s1951 csa73 441
cellular location: CELL

PARTICIPANT STOICHIOMETRY re48 761
type: Stoichiometry
physical entity: G34-Gly
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re48 762
type: Stoichiometry
physical entity: G34
stoichiometric coefficient: 1.0

mLST8 s922 sa313 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mLST8 s922 sa313
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: PTHR44329:SF47
xref: uniprot P15056 157
organism: Homo sapiens

ATF2 s1835 sa330 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__IkB_kinase_complex-RIGHT__IkB_kinase_complex-_re38
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 809
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 810
left: IkB kinase complex
interaction type: STATE_TRANSITION
right: IkB kinase complex

I441 CCK2R s1660 sa22 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY I441
feature location: I441 CCK2R s1660 sa22 rs9 I441
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.567911979799767
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=I441

PAI1
type: DnaRegion
entity reference: PAI1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

ITGB1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.ITGB1
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re485 1055
type: Stoichiometry
physical entity: FAK1-SRC complex
stoichiometric coefficient: 1.0

HBEGF
type: DnaRegionReference
member entity reference: Proheparin-binding EGF-like growth factor
xref: G07261
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.HBEGF
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re485 1056
type: Stoichiometry
physical entity: FAK1-SRC-p190GEF complex
stoichiometric coefficient: 1.0

Lithostathine-1-alpha
type: DnaReference
xref: PTHR22803:SF105
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__Ca2_PLUS_-_CaM-RIGHT__Ca_CaM-_re665
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re665 621
participant stoichiometry: PARTICIPANT STOICHIOMETRY re665 623
participant stoichiometry: PARTICIPANT STOICHIOMETRY re665 622
left: CaM
left: Ca2+
interaction type: HETERODIMER_ASSOCIATION
right: Ca_CaM

S259 RAF1 s1330 sa689 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S259
feature location: S259 RAF1 s1330 sa689 rs3 S259
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S259
comment: MODIFICATION_RESIDUE_ANGLE=2.328231397687482

PARTICIPANT STOICHIOMETRY re452 1152
type: Stoichiometry
physical entity: ACAT1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re452 1153
type: Stoichiometry
physical entity: ACAT1
stoichiometric coefficient: 1.0

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re556
controller: PKA-Calpha/beta/gamma

CALCA
type: RnaRegion
entity reference: CALCA
cellular location: CELL
comment: SPECIES_TYPE=RNA

STATE_TRANSITION_LEFT__CREB1-RIGHT__CREB1-_re188
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re188 824
participant stoichiometry: PARTICIPANT STOICHIOMETRY re188 825
left: CREB1
interaction type: STATE_TRANSITION
right: CREB1

SOS1
type: Protein
entity reference: SOS1
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s890 sa281 248
feature: S SOS1 s890 sa281 rs2
feature: T SOS1 s890 sa281 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PLA2-RIGHT__PLA2-_re542
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re542 967
participant stoichiometry: PARTICIPANT STOICHIOMETRY re542 968
left: PLA2
interaction type: STATE_TRANSITION
right: PLA2

PPARgamma
type: Protein
entity reference: PPARgamma
feature: S84 PPARgamma s1445 sa778 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Catenin beta-1
type: ProteinReference
xref: uniprot P35222 101
xref: PTHR45976:SF4
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re53 723
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re53 724
type: Stoichiometry
physical entity: p54 SRC
stoichiometric coefficient: 1.0

Y G17 Gly s10 sa84 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y G17 Gly s10 sa84 rs1 Y
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.7913212264698272

CaMKK
type: ProteinReference
xref: P07034
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CaMKK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Calcium/calmodulin-dependent protein kinase kinase 1

PKA-Calpha/beta/gamma
type: Protein
entity reference: PKA-Calpha/beta/gamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s1523 sa831 322
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S103 SRF s1060 sa746 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S103
feature location: S103 SRF s1060 sa746 rs1 S103
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S103
comment: MODIFICATION_RESIDUE_ANGLE=0.7120943348136864

KNOWN_TRANSITION_OMITTED_LEFT__SRC_@Galphaq-RIGHT__p60_SRC-_re54
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re54 722
participant stoichiometry: PARTICIPANT STOICHIOMETRY re54 721
left: SRC @Galphaq
interaction type: KNOWN_TRANSITION_OMITTED
right: p60 SRC

HOMODIMER ID 91STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Adenylate_cyclase-RIGHT__Adenylate_cyclase-_re294
controller: GalphaS

uniprot P06756 129
type: UnificationXref
id: P06756
db: uniprot

S112 BAD s791 sa149 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S112
feature location: S112 BAD s791 sa149 rs1 S112
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.538835828280262
comment: MODIFICATION_RESIDUE_NAME=S112

ATF2 s1283 sa757 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 2.0

S133 CREB1 s188 sa332 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S133
feature location: S133 CREB1 s188 sa332 rs1 S133
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S133
comment: MODIFICATION_RESIDUE_ANGLE=0.693598378065279

KNOWN_TRANSITION_OMITTED_LEFT__Atypical_PKC-RIGHT__PKC-_re24
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 859
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 858
left: Atypical PKC
interaction type: KNOWN_TRANSITION_OMITTED
right: PKC

TRANSPORT_LEFT__E_cadherin-RIGHT__E_cadherin-_re375
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re375 1219
participant stoichiometry: PARTICIPANT STOICHIOMETRY re375 1218
left: E-cadherin
interaction type: TRANSPORT
right: E-cadherin

PTHR24243:SF45
type: RelationshipXref
id: PTHR24243:SF45
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

MAP2K6
type: Protein
entity reference: MAP2K6
feature: T211 MAP2K6 s997 sa224 rs2
feature: S207 MAP2K6 s997 sa224 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

uniprot P61586 9
type: UnificationXref
id: P61586
db: uniprot

PARTICIPANT STOICHIOMETRY re591 769
type: Stoichiometry
physical entity: ROCK1
stoichiometric coefficient: 1.0

BCL2 s808 sa294 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BCL2
stoichiometric coefficient: 1.0

BCL2 s1771 sa289 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BCL2
stoichiometric coefficient: 1.0

Beta-arrestin-1/2
type: ProteinReference
xref: P07187
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Beta-arrestin-1/2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Gastrin
member entity reference: Beta-arrestin-2

GalphaS s1182 sa490 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GalphaS
stoichiometric coefficient: 1.0

Y317 SHC1 @EGFR s892 sa268 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y317
feature location: Y317 SHC1 @EGFR s892 sa268 rs1 Y317
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7472271186373366
comment: MODIFICATION_RESIDUE_NAME=Y317

TRUNCATION
type: InteractionVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p52_SHC1-RIGHT__p52_SHC1-_re59
controller: PKC

HBEGF
type: Protein
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s874 sa267 234
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S33 beta catenin s1852 sa183 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S33
feature location: S33 beta catenin s1852 sa183 rs2 S33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7304919088134321
comment: MODIFICATION_RESIDUE_NAME=S33

CCK-58
type: ProteinReference
xref: P07164
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CCK-58
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

HDAC7
type: Protein
entity reference: HDAC7
feature: S181 HDAC7 s1821 sa739 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

uPA
type: DnaRegionReference
member entity reference: Urokinase-type plasminogen activator
xref: G07267
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.uPA
comment: ENTITY_REFERENCE_NOTES=

beta-catenin
type: ProteinReference
xref: P07150
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC._beta_-catenin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Catenin beta-1

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Conventional_PKC-RIGHT__Conventional_PKC-_re19
control type: ACTIVATION
controller: Ca2+

GDP
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Y577 FAK1 s1450 sa782 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y577
feature location: Y577 FAK1 s1450 sa782 rs4 Y577
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.29
comment: MODIFICATION_RESIDUE_NAME=Y577

TRANSCRIPTION_LEFT__IEX1-RIGHT__IEX1-_re608
type: TemplateReaction
product: IEX1
xref: TRANSCRIPTION
participant: IEX1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

ARHGAP4
type: Protein
entity reference: ARHGAP4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re523 1048
type: Stoichiometry
physical entity: HRAS-GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re523 1047
type: Stoichiometry
physical entity: HRAS-GDP
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Ca_CaM-_CaN-RIGHT__Ca_CaM-_re667
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re667 618
participant stoichiometry: PARTICIPANT STOICHIOMETRY re667 617
participant stoichiometry: PARTICIPANT STOICHIOMETRY re667 616
left: Ca_CaM
left: CaN
interaction type: HETERODIMER_ASSOCIATION
right: Ca_CaM

Acetyl-CoA acetyltransferase, mitochondrial
type: DnaReference
xref: PTHR18919:SF156
organism: Homo sapiens

S473 AKT1 s913 sa301 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S473
feature location: S473 AKT1 s913 sa301 rs2 S473
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S473
comment: MODIFICATION_RESIDUE_ANGLE=5.615596868291756

COX2
type: Protein
entity reference: COX2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pro_CCK_@_TGN-RIGHT__Pro_CCK_@_secretory_granule-_re303
controller: Prohormone convertase

BCL2L1 s801 sa292 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BCL2L1
stoichiometric coefficient: 1.0

uniprot P63000 74
type: UnificationXref
id: P63000
db: uniprot

S621 RAF1 s731 sa687 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S621
feature location: S621 RAF1 s731 sa687 rs9 S621
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S621
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.46201537231871

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAP2K4-RIGHT__MAP2K4-_re150
controller: MAP3K11

PARTICIPANT STOICHIOMETRY re145 981
type: Stoichiometry
physical entity: RSK1/2
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p66_SHC1-RIGHT__p66_SHC1-_re61
controller: PKC

S36 p66 SHC1 s713 sa102 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S36
feature location: S36 p66 SHC1 s713 sa102 rs3 S36
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S36

PARTICIPANT STOICHIOMETRY re145 982
type: Stoichiometry
physical entity: RSK1/2
stoichiometric coefficient: 1.0

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1803 sa74 458
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

p62 SRC
type: Protein
entity reference: p62 SRC
feature: Y527 p62 SRC s881 sa98 rs2
feature: ACTIVE 13
feature: Y416 p62 SRC s881 sa98 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

MAPK1/3
type: ProteinReference
xref: P07228
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAPK1/3
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase 3

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__IEX1-RIGHT__IEX1-_re608
controller: AP1 (FOS+JUN)

RSK1/2
type: Protein
entity reference: RSK1/2
feature: T359 RSK1 2 s538 sa212 rs2
feature: S749 RSK1 2 s538 sa212 rs6
feature: S221 RSK1 2 s538 sa212 rs5
feature: S363 RSK1 2 s538 sa212 rs1
feature: S380 RSK1 2 s538 sa212 rs4
feature: T573 RSK1 2 s538 sa212 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR10614:SF11
type: RelationshipXref
id: PTHR10614:SF11
db: PANTHER Family
relationship type: By Homology

uniprot Q03060 106
type: UnificationXref
id: Q03060
db: uniprot

PTHR24216:SF11
type: RelationshipXref
id: PTHR24216:SF11
db: PANTHER Family
relationship type: By Homology

S221 RSK1 2 s539 sa214 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 RSK1 2 s539 sa214 rs5 S221
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=3.8909266156067464
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221

CaMKIV
type: Protein
entity reference: CaMKIV
feature: CaMKIV s2008 sa1006 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CDC42-GDP
type: ProteinReference
xref: P07044
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CDC42-GDP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cell division control protein 42 homolog

IEX1
type: DnaRegionReference
member entity reference: Radiation-inducible immediate-early gene IEX-1
xref: G07263
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.IEX1
comment: ENTITY_REFERENCE_NOTES=

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FOS-RIGHT__FOS-_re621
controller: PP2B

Tyrosine-protein kinase Lyn
type: ProteinReference
xref: uniprot P07948 165
xref: PTHR24418:SF42
organism: Homo sapiens

Tyrosine-protein kinase Yes
type: ProteinReference
xref: PTHR24418:SF90
xref: uniprot P07947 23
organism: Homo sapiens

Pro CCK @ TGN
type: Protein
entity reference: Pro CCK @ TGN
feature: Y77 Pro CCK @ TGN s1191 sa499 rs1
feature: Y94 Pro CCK @ TGN s1191 sa499 rs3
feature: Y91 Pro CCK @ TGN s1191 sa499 rs2
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RHOA_GDP-_GTP-RIGHT__GDP-_RHOA_GTP-_re74
controller: HRAS-GTP

PARTICIPANT STOICHIOMETRY re497 1018
type: Stoichiometry
physical entity: CCK-58
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re305 624
type: Stoichiometry
physical entity: CCK-GRR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re305 625
type: Stoichiometry
physical entity: CCK-G
stoichiometric coefficient: 1.0

HuR
type: Protein
entity reference: HuR
feature: S158 HuR s1380 sa723 rs1
feature: S221 HuR s1380 sa723 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Progastrin_@ER___Golgi-RIGHT__Progastrin_@Golgi-_re478
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re478 1085
participant stoichiometry: PARTICIPANT STOICHIOMETRY re478 1084
left: Progastrin @ER - Golgi
interaction type: STATE_TRANSITION
right: Progastrin @Golgi

TRANSCRIPTION_LEFT__TAC1-RIGHT__TAC1-_re508
type: TemplateReaction
product: TAC1
xref: TRANSCRIPTION
participant: TAC1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

RHOA-GTP
type: ProteinReference
xref: P07188
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RHOA-GTP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Transforming protein RhoA

PARTICIPANT STOICHIOMETRY re650 671
type: Stoichiometry
physical entity: FOXO1
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__Galpha13beta_gamma-_GTP-RIGHT__Galpha13-_GDP-_Gbeta_gamma-_re337
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re337 543
participant stoichiometry: PARTICIPANT STOICHIOMETRY re337 542
participant stoichiometry: PARTICIPANT STOICHIOMETRY re337 545
participant stoichiometry: PARTICIPANT STOICHIOMETRY re337 544
participant stoichiometry: PARTICIPANT STOICHIOMETRY re337 541
left: GTP
left: Galpha13beta/gamma
interaction type: DISSOCIATION
right: Gbeta/gamma
right: GDP
right: Galpha13

PARTICIPANT STOICHIOMETRY re650 672
type: Stoichiometry
physical entity: FOXO1
stoichiometric coefficient: 1.0

Novel PKC
type: Protein
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y460 CAS s766 sa287 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y460
feature location: Y460 CAS s766 sa287 rs4 Y460
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y460
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.426319326209974

STATE_TRANSITION_LEFT__JUN-RIGHT__JUN-_re166
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re166 916
participant stoichiometry: PARTICIPANT STOICHIOMETRY re166 917
left: JUN
interaction type: STATE_TRANSITION
right: JUN

T573 RSK1 2 s1856 sa215 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T573
feature location: T573 RSK1 2 s1856 sa215 rs3 T573
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=T573

MAP3K14
type: ProteinReference
xref: P07063
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAP3K14
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mitogen-activated protein kinase kinase kinase 14

RAC1-GDP
type: ProteinReference
xref: P07225
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RAC1-GDP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ras-related C3 botulinum toxin substrate 1

PTHR19309:SF0
type: RelationshipXref
id: PTHR19309:SF0
db: PANTHER Family
relationship type: By Homology

Cytochrome C
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

S749 RSK1 2 s539 sa214 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S749
feature location: S749 RSK1 2 s539 sa214 rs6 S749
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=S749
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.408013221559381

CCND1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.CCND1
comment: ENTITY_REFERENCE_NOTES=

RAC1-GTP
type: ProteinReference
xref: P07214
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RAC1-GTP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ras-related C3 botulinum toxin substrate 1

S154 CCK2R s1688 sa565 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S154
feature location: S154 CCK2R s1688 sa565 rs3 S154
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.234636338452209
comment: MODIFICATION_RESIDUE_NAME=S154

Beta arrestin 1 2 s1690 sa567 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Beta-arrestin-1/2
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__HuR_IL8-RIGHT__IL8-_re436
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re436 1178
participant stoichiometry: PARTICIPANT STOICHIOMETRY re436 1179
left: HuR-IL8
interaction type: KNOWN_TRANSITION_OMITTED
right: IL8

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__STAT3-RIGHT__STAT3-_re161
controller: JAK2

TFF2
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.TFF2
comment: ENTITY_REFERENCE_NOTES=

MMP7
type: RnaRegion
entity reference: MMP7
cellular location: CELL
comment: SPECIES_TYPE=RNA

S272 MAPKAP K2 s1584 sa871 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S272
feature location: S272 MAPKAP K2 s1584 sa871 rs2 S272
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S272
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.33

Y527 SRC @Galphaq s719 sa95 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 SRC @Galphaq s719 sa95 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.585857905576321
comment: MODIFICATION_RESIDUE_NAME=Y527

PARTICIPANT STOICHIOMETRY re497 1017
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

MAP2K6
type: Protein
entity reference: MAP2K6
feature: ACTIVE 13
feature: T211 MAP2K6 s965 sa226 rs2
feature: S207 MAP2K6 s965 sa226 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Glycogen synthase kinase-3 beta
type: ProteinReference
xref: PTHR24057:SF8
xref: uniprot P49841 29
organism: Homo sapiens

S103 SRF s1061 sa747 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S103
feature location: S103 SRF s1061 sa747 rs1 S103
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S103
comment: MODIFICATION_RESIDUE_ANGLE=0.7120943348136864

TRANSPORT_LEFT__ACAT1-RIGHT__ACAT1-_re467
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re467 1121
participant stoichiometry: PARTICIPANT STOICHIOMETRY re467 1120
left: ACAT1
interaction type: TRANSPORT
right: ACAT1

uniprot P59768 77
type: UnificationXref
id: P59768
db: uniprot

PARTICIPANT STOICHIOMETRY re502 1112
type: Stoichiometry
physical entity: MOB1
stoichiometric coefficient: 1.0

Gbeta s1372 sa698 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re502 1111
type: Stoichiometry
physical entity: MOB1
stoichiometric coefficient: 1.0

uniprot Q99075 126
type: UnificationXref
id: Q99075
db: uniprot

Focal adhesion kinase 1
type: ProteinReference
xref: uniprot Q05397 73
xref: PTHR24418:SF78
organism: Homo sapiens

STATE_TRANSITION_LEFT__NFAT1-RIGHT__NFAT1-_re668
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re668 613
participant stoichiometry: PARTICIPANT STOICHIOMETRY re668 612
left: NFAT1
interaction type: STATE_TRANSITION
right: NFAT1

STATE_TRANSITION_LEFT__NFAT1-RIGHT__NFAT1-_re669
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re669 611
participant stoichiometry: PARTICIPANT STOICHIOMETRY re669 610
left: NFAT1
interaction type: STATE_TRANSITION
right: NFAT1

Y418 SRC @Galphaq s1599 sa887 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y418
feature location: Y418 SRC @Galphaq s1599 sa887 rs3 Y418
comment: MODIFICATION_RESIDUE_NAME=Y418
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3192345766207003

T219 MAPK7 s471 sa232 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T219
feature location: T219 MAPK7 s471 sa232 rs1 T219
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.387506044879286
comment: MODIFICATION_RESIDUE_NAME=T219

S112 BAD s1565 sa857 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S112
feature location: S112 BAD s1565 sa857 rs1 S112
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.538835828280262
comment: MODIFICATION_RESIDUE_NAME=S112

MAP2K5
type: Protein
entity reference: MAP2K5
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TAC1
type: DnaRegionReference
member entity reference: Protachykinin-1
xref: G07294
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.TAC1
comment: ENTITY_REFERENCE_NOTES=

PTHR24346:SF39
type: RelationshipXref
id: PTHR24346:SF39
db: PANTHER Family
relationship type: By Homology

Pre-pro CCK @ ER
type: Protein
entity reference: Pre-pro CCK @ ER
feature: Y94 Pre pro CCK @ ER s1189 sa497 rs3
feature: Y91 Pre pro CCK @ ER s1189 sa497 rs2
feature: Y77 Pre pro CCK @ ER s1189 sa497 rs1
comment: SPECIES_TYPE=PROTEIN

Y204 MAPK1 3 s827 sa217 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y204
feature location: Y204 MAPK1 3 s827 sa217 rs4 Y204
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.500664060131579
comment: MODIFICATION_RESIDUE_NAME=Y204

PKA Calpha beta gamma s1523 sa831 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PKA-Calpha/beta/gamma
stoichiometric coefficient: 1.0

S363 RSK1 2 s538 sa212 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S363
feature location: S363 RSK1 2 s538 sa212 rs1 S363
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=2.378634437717986
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S363

CCK-G
type: ProteinReference
xref: P07062
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CCK-G
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

G17
type: Protein
entity reference: G17
feature: Y G17 s1411 sa569 rs1
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s1411 sa569 228
cellular location: Endosome
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re636 736
type: Stoichiometry
physical entity: BCL2L1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re636 735
type: Stoichiometry
physical entity: BCL2L1
stoichiometric coefficient: 1.0

PTHR48016:SF9
type: RelationshipXref
id: PTHR48016:SF9
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re4
controller: RYR1/2/3

IL8
type: DnaRegion
entity reference: IL8
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

JUN
type: Protein
entity reference: JUN
feature: S63 JUN s191 sa236 rs1
feature: S73 JUN s191 sa236 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION_LEFT__E_cadherin-RIGHT__E_cadherin-_re372
type: TemplateReaction
product: E-cadherin
xref: TRANSCRIPTION
participant: E-cadherin
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

NFAT1
type: Protein
entity reference: NFAT1
feature: ACTIVE 13
feature: S NFAT1 s2017 sa1014 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

MMP9
type: RnaRegion
entity reference: MMP9
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__MMP9-RIGHT__MMP9-_re420
controller: AP1 (FOS+JUN)

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__mTORC1_complex-RIGHT__mTORC1_complex-_re112
control type: INHIBITION
controller: PRAS40

S SOS1 s943 sa272 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S SOS1 s943 sa272 rs2 S
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.511144255404544

Proliferation
type: Pathway

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Phospholipid-RIGHT__AA-_re544
controller: PLA2 s1516 sa827

Ca2+
type: SmallMolecule
cellular location: Lysosome
comment: SPECIES_TYPE=ION

uniprot P17612 107
type: UnificationXref
id: P17612
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re295
controller: Adenylate cyclase

uniprot P28482 140
type: UnificationXref
id: P28482
db: uniprot

STATE_TRANSITION_LEFT__FOXO3-RIGHT__FOXO3-_re582
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re582 812
participant stoichiometry: PARTICIPANT STOICHIOMETRY re582 811
left: FOXO3
interaction type: STATE_TRANSITION
right: FOXO3

Y221 MAPK7 s1972 sa990 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y221
feature location: Y221 MAPK7 s1972 sa990 rs2 Y221
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=Y221
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_TYPE=residue

NR4A1
type: DnaRegion
entity reference: NR4A1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PLCgamma1-RIGHT__PLCgamma1-_re583
control type: ACTIVATION
controller: CCK2R

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_RAF___RAF1-RIGHT__c_RAF___RAF1-_re173
controller: HRAS-GTP

PARTICIPANT STOICHIOMETRY re489 1049
type: Stoichiometry
physical entity: CCK-83
stoichiometric coefficient: 1.0

uniprot Q92736 27
type: UnificationXref
id: Q92736
db: uniprot

HRAS
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1805 sa73 386
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1775 sa23 380
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RAC1_GDP-_GTP-RIGHT__RAC1_GTP-_GDP-_re76
controller: Galpha q complex

Y77 Pre pro CCK @ ER s1189 sa497 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 Pre pro CCK @ ER s1189 sa497 rs1 Y77
comment: MODIFICATION_RESIDUE_ANGLE=2.3689767387829
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y77

MAPKAP-K2
type: Protein
entity reference: MAPKAP K2 PROTEIN
feature: T222 MAPKAP K2 s1583 sa870 rs1
feature: T334 MAPKAP K2 s1583 sa870 rs3
feature: S272 MAPKAP K2 s1583 sa870 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

4E BP1 s652 sa168 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.786798160123647

PARTICIPANT STOICHIOMETRY re489 1050
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

GRB2
type: Protein
entity reference: GRB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1607 sa888 442
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controller: PI3,4,5-P3

uniprot Q08209 156
type: UnificationXref
id: Q08209
db: uniprot

Forkhead box protein O3
type: ProteinReference
xref: PTHR45767:SF4
xref: uniprot O43524 58
organism: Homo sapiens

P07140
type: UnificationXref
id: P07140
db: PANTHER Pathway Component

PTHR28540:SF1
type: RelationshipXref
id: PTHR28540:SF1
db: PANTHER Family
relationship type: By Homology

P07141
type: UnificationXref
id: P07141
db: PANTHER Pathway Component

P07145
type: UnificationXref
id: P07145
db: PANTHER Pathway Component

P07142
type: UnificationXref
id: P07142
db: PANTHER Pathway Component

P07143
type: UnificationXref
id: P07143
db: PANTHER Pathway Component

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q02156 135
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re364 513
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

P07148
type: UnificationXref
id: P07148
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re364 514
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

P07149
type: UnificationXref
id: P07149
db: PANTHER Pathway Component

P07146
type: UnificationXref
id: P07146
db: PANTHER Pathway Component

PDPK1
type: Protein
entity reference: PDPK1
feature: COMPLEX PARTICIPANT BINDING FEATURE s902 sa306 272
feature: ACTIVE 13
feature: S241 PDPK1 s902 sa306 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Caspase-3
type: Protein
entity reference: Caspase-3
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

SHC
type: Protein
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

IKKalpha s1814 sa260 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IKKalpha s1814 sa260
stoichiometric coefficient: 1.0

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot P31946 122
xref: PTHR18860:SF28
organism: Homo sapiens

P07150
type: UnificationXref
id: P07150
db: PANTHER Pathway Component

P07151
type: UnificationXref
id: P07151
db: PANTHER Pathway Component

P07152
type: UnificationXref
id: P07152
db: PANTHER Pathway Component

P07153
type: UnificationXref
id: P07153
db: PANTHER Pathway Component

P07154
type: UnificationXref
id: P07154
db: PANTHER Pathway Component

TRANSCRIPTION_LEFT__uPA-RIGHT__uPA-_re605
type: TemplateReaction
product: uPA
xref: TRANSCRIPTION
participant: uPA
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

P07155
type: UnificationXref
id: P07155
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__BAD_BCL2L1_heterodimer-RIGHT__BAD_BCL2L1_heterodimer-_re578
controller: AKT1-PIP3

P07156
type: UnificationXref
id: P07156
db: PANTHER Pathway Component

P07157
type: UnificationXref
id: P07157
db: PANTHER Pathway Component

P07158
type: UnificationXref
id: P07158
db: PANTHER Pathway Component

P07159
type: UnificationXref
id: P07159
db: PANTHER Pathway Component

Y390 CCK2R s1660 sa22 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y390
feature location: Y390 CCK2R s1660 sa22 rs1 Y390
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4010743852436276
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y390

TRANSLATION
type: InteractionVocabulary

T71 ATF2 s1835 sa330 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T71
feature location: T71 ATF2 s1835 sa330 rs2 T71
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5248232251383325
comment: MODIFICATION_RESIDUE_NAME=T71

HETERODIMER_ASSOCIATION_LEFT__Complex__GRB2_SOS1_-_SHC1_@EGFR-RIGHT__SHC1_GRB2_SOS1-_re66
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re66 685
participant stoichiometry: PARTICIPANT STOICHIOMETRY re66 684
participant stoichiometry: PARTICIPANT STOICHIOMETRY re66 683
left: Complex (GRB2/SOS1)
left: SHC1 @EGFR
interaction type: HETERODIMER_ASSOCIATION
right: SHC1-GRB2-SOS1

PTHR13809:SF25
type: RelationshipXref
id: PTHR13809:SF25
db: PANTHER Family
relationship type: By Homology

Y77 CCK GRR s877 sa501 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 CCK GRR s877 sa501 rs1 Y77
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4376728710890188
comment: MODIFICATION_RESIDUE_NAME=Y77

STATE_TRANSITION_LEFT__NFKB1_RELA_heterodimer-RIGHT__BIRC2-_re614
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re614 830
participant stoichiometry: PARTICIPANT STOICHIOMETRY re614 831
left: NFKB1/RELA heterodimer
interaction type: STATE_TRANSITION
right: BIRC2

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SRC_@Galphaq-RIGHT__SRC_@Galphaq-_re52
controller: SRC @Galphaq

P07166
type: UnificationXref
id: P07166
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_CDC42_GDP-RIGHT__GDP-_CDC42_GTP-_re78
controller: GEF

P07167
type: UnificationXref
id: P07167
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__mTORC1_complex-RIGHT__mTORC1_complex-_re115
controller: RHEB-GTP

PARTICIPANT STOICHIOMETRY re483 1059
type: Stoichiometry
physical entity: PPARgamma
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re295
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re295 560
participant stoichiometry: PARTICIPANT STOICHIOMETRY re295 561
left: ATP
interaction type: STATE_TRANSITION
right: cAMP s1840 sa472

P07164
type: UnificationXref
id: P07164
db: PANTHER Pathway Component

P07165
type: UnificationXref
id: P07165
db: PANTHER Pathway Component

P07162
type: UnificationXref
id: P07162
db: PANTHER Pathway Component

Y416 p62 SRC s881 sa98 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 p62 SRC s881 sa98 rs1 Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7706648645169767
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416

P07163
type: UnificationXref
id: P07163
db: PANTHER Pathway Component

S246 SNAI1 s970 sa189 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S246
feature location: S246 SNAI1 s970 sa189 rs1 S246
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S246

P07160
type: UnificationXref
id: P07160
db: PANTHER Pathway Component

CXCL2
type: DnaRegionReference
member entity reference: C-X-C motif chemokine 2
xref: G07265
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.CXCL2
comment: ENTITY_REFERENCE_NOTES=

P07161
type: UnificationXref
id: P07161
db: PANTHER Pathway Component

S253 FOXO3 s1625 sa902 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S253
feature location: S253 FOXO3 s1625 sa902 rs2 S253
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S253
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4291919098540697

PARTICIPANT STOICHIOMETRY re509 1105
type: Stoichiometry
physical entity: TAC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re509 1106
type: Stoichiometry
physical entity: TAC1
stoichiometric coefficient: 1.0

CHGA
type: RnaRegion
entity reference: CHGA RNA
cellular location: CELL
comment: SPECIES_TYPE=RNA

Y IRS1 s911 sa282 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y IRS1 s911 sa282 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.7039197825007742

Amidating enzyme
type: Protein
comment: SPECIES_TYPE=PROTEIN

P07168
type: UnificationXref
id: P07168
db: PANTHER Pathway Component

RYR1/2/3
type: Protein
entity reference: RYR1/2/3
feature: ACTIVE 13
cellular location: Endoplasmic Reticulum
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re483 1060
type: Stoichiometry
physical entity: PPARgamma
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__FOS-RIGHT__FOS-_re164
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re164 920
participant stoichiometry: PARTICIPANT STOICHIOMETRY re164 921
left: FOS
interaction type: STATE_TRANSITION
right: FOS

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p52_SHC1-RIGHT__p52_SHC1-_re59
controller: PKCdelta

Y402 FAK2 s1604 sa880 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y402
feature location: Y402 FAK2 s1604 sa880 rs1 Y402
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.37
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y402

PTHR21844:SF2
type: RelationshipXref
id: PTHR21844:SF2
db: PANTHER Family
relationship type: By Homology

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P60953 61
xref: PTHR24072:SF136
organism: Homo sapiens

Paxillin
type: ProteinReference
xref: P07145
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Paxillin
member entity reference: Paxillin

P07175
type: UnificationXref
id: P07175
db: PANTHER Pathway Component

Early growth response protein 1
type: ProteinReference
xref: PTHR23235:SF42
xref: uniprot P18146 82
organism: Homo sapiens

P07176
type: UnificationXref
id: P07176
db: PANTHER Pathway Component

T ROCK1 s788 sa137 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T
feature location: T ROCK1 s788 sa137 rs2 T
comment: MODIFICATION_RESIDUE_ANGLE=0.7629582158718069
comment: MODIFICATION_RESIDUE_NAME=T
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

P07177
type: UnificationXref
id: P07177
db: PANTHER Pathway Component

PTHR10082:SF28
type: RelationshipXref
id: PTHR10082:SF28
db: PANTHER Family
relationship type: By Homology

P07178
type: UnificationXref
id: P07178
db: PANTHER Pathway Component

P07171
type: UnificationXref
id: P07171
db: PANTHER Pathway Component

P07174
type: UnificationXref
id: P07174
db: PANTHER Pathway Component

NFKB1 (p50)
type: Protein
feature: NFKB1 p50 s1747 sa264 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1747 sa264 448
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

go GO:0005764 5
type: UnificationXref
id: GO:0005764
db: go

CALCA
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.CALCA

RELA p65 s1884 sa974 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RELA (p65)
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__G34_Gly-RIGHT__G34-_re48
controller: PAM

L-Arg
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re379 1207
type: Stoichiometry
physical entity: PKCepsilon
stoichiometric coefficient: 1.0

P07170
type: UnificationXref
id: P07170
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re379 1206
type: Stoichiometry
physical entity: PKCepsilon
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATF2-RIGHT__ATF2-_re460
controller: MAPK8-10

PDPK1
type: Protein
entity reference: PDPK1
feature: ACTIVE 13
feature: S241 PDPK1 s1669 sa213 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

EGR1
type: Protein
entity reference: EGR1
feature: ACTIVE 13
feature: EGR1 s1705 sa336 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__CCK-RIGHT__CCK_22-_re499
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re499 1009
participant stoichiometry: PARTICIPANT STOICHIOMETRY re499 1010
left: CCK
interaction type: STATE_TRANSITION
right: CCK-22

P07184
type: UnificationXref
id: P07184
db: PANTHER Pathway Component

P07182
type: UnificationXref
id: P07182
db: PANTHER Pathway Component

P07189
type: UnificationXref
id: P07189
db: PANTHER Pathway Component

P07188
type: UnificationXref
id: P07188
db: PANTHER Pathway Component

G1/S-specific cyclin-D1
type: DnaReference
xref: PTHR10177:SF67
organism: Homo sapiens

P07187
type: UnificationXref
id: P07187
db: PANTHER Pathway Component

NFKB/RELA heterodimer
type: Complex
component stoichiometry: NFKB1 p50 s1747 sa264 STOICHIOMETRY ID COMPLEX
component stoichiometry: RELA p65 s1748 sa265 STOICHIOMETRY ID COMPLEX
component: RELA (p65)
component: NFKB1 (p50)
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s1945 csa6 449
feature: COMPLEX BINDING FEATURE s1945 csa6 447
cellular location: CELL

P07180
type: UnificationXref
id: P07180
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re629 781
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

PTHR13944:SF22
type: RelationshipXref
id: PTHR13944:SF22
db: PANTHER Family
relationship type: By Homology

P07181
type: UnificationXref
id: P07181
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re629 782
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

Y94 Pro CCK @ secretory granule s1192 sa500 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 Pro CCK @ secretory granule s1192 sa500 rs3 Y94
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.536122054138442
comment: MODIFICATION_RESIDUE_NAME=Y94

IEX1
type: RnaRegion
entity reference: IEX1
cellular location: CELL
comment: SPECIES_TYPE=RNA

KLF4
type: ProteinReference
xref: P07227
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.KLF4
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Krueppel-like factor 4

KNOWN_TRANSITION_OMITTED_LEFT__MCL1-RIGHT__MCL1-_re567
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re567 886
participant stoichiometry: PARTICIPANT STOICHIOMETRY re567 887
left: MCL1
interaction type: KNOWN_TRANSITION_OMITTED
right: MCL1

S246 SNAI1 s1854 sa190 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S246
feature location: S246 SNAI1 s1854 sa190 rs1 S246
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S246

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CETP-RIGHT__CETP-_re468
controller: ACAT1

Ribosomal protein S6 kinase alpha-3
type: ProteinReference
xref: PTHR24351:SF58
xref: uniprot P51812 119
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re602 883
type: Stoichiometry
physical entity: CLU
stoichiometric coefficient: 1.0

Y580 FAK2 s1598 sa886 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y580
feature location: Y580 FAK2 s1598 sa886 rs3 Y580
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y580
comment: MODIFICATION_RESIDUE_ANGLE=0.75

P07194
type: UnificationXref
id: P07194
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re602 882
type: Stoichiometry
physical entity: CLU
stoichiometric coefficient: 1.0

T41 beta catenin s1274 sa636 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T41
feature location: T41 beta catenin s1274 sa636 rs4 T41
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T41
comment: MODIFICATION_RESIDUE_ANGLE=2.3739822534748654

P07193
type: UnificationXref
id: P07193
db: PANTHER Pathway Component

PKCdelta
type: Protein
entity reference: PKCdelta
feature: T505 PKCdelta s1709 sa26 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CCK_G-RIGHT__CCK-_re494
controller: Amidating enzyme

P07198
type: UnificationXref
id: P07198
db: PANTHER Pathway Component

P07197
type: UnificationXref
id: P07197
db: PANTHER Pathway Component

S21 FOS s1858 sa234 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S21
feature location: S21 FOS s1858 sa234 rs1 S21
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S21
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.348702615819714

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEF2-RIGHT__MEF2-_re631
controller: MAPK7

P07199
type: UnificationXref
id: P07199
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__SAP1-RIGHT__SAP1-_re599
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re599 749
participant stoichiometry: PARTICIPANT STOICHIOMETRY re599 750
left: SAP1
interaction type: STATE_TRANSITION
right: SAP1

FOS
type: Protein
entity reference: FOS
feature: S32 FOS s1040 sa339 rs2
feature: ACTIVE 13
feature: S70 FOS s1040 sa339 rs4
feature: S21 FOS s1040 sa339 rs1
feature: S133 FOS s1040 sa339 rs5
feature: COMPLEX PARTICIPANT BINDING FEATURE s1040 sa339 214
feature: S42 FOS s1040 sa339 rs3
feature: S374 FOS s1040 sa339 rs6
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

FAK2 s1604 sa880 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK2 s1604 sa880
stoichiometric coefficient: 1.0

P07190
type: UnificationXref
id: P07190
db: PANTHER Pathway Component

G34
type: Protein
entity reference: G34
feature: Y G34 s11 sa85 rs1
comment: SPECIES_TYPE=PROTEIN

GMP
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P07192
type: UnificationXref
id: P07192
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re630 752
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

RYR1/2/3
type: Protein
entity reference: RYR1/2/3
cellular location: Endoplasmic Reticulum
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re630 751
type: Stoichiometry
physical entity: EGR1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NFAT1-RIGHT__NFAT1-_re668
controller: Ca_CaM

BAX s1559 sa854 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__PAI1-RIGHT__PAI1-_re604
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re604 880
participant stoichiometry: PARTICIPANT STOICHIOMETRY re604 881
left: PAI1
interaction type: TRANSPORT
right: PAI1

S244 PRKD2 s1388 sa736 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S244
feature location: S244 PRKD2 s1388 sa736 rs6 S244
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S244
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.822805346332478

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re4
controller: IP3R

HDAC7
type: Protein
entity reference: HDAC7
feature: S181 HDAC7 s1391 sa740 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

TFF2
type: RnaRegion
entity reference: TFF2
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

FOS
type: DnaRegion
entity reference: FOS
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Y91 CCK s1911 sa947 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y91
feature location: Y91 CCK s1911 sa947 rs2 Y91
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7668909901804244
comment: MODIFICATION_RESIDUE_NAME=Y91
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

REG1A
type: DnaRegionReference
member entity reference: Lithostathine-1-alpha
xref: G07269
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.REG1A
comment: ENTITY_REFERENCE_NOTES=

Galpha13
type: Complex
component stoichiometry: Galpha13 s139 sa574 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s140 sa575 STOICHIOMETRY ID COMPLEX
component: GTP s140 sa575
component: Galpha13
feature: COMPLEX BINDING FEATURE s2019 csa56 481
feature: COMPLEX BINDING FEATURE s2019 csa56 479
cellular location: CELL

A-Raf
type: ProteinReference
xref: P07220
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.A-Raf
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Serine/threonine-protein kinase A-Raf

TRANSPORT_LEFT__HDAC7-RIGHT__HDAC7-_re448
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re448 1160
participant stoichiometry: PARTICIPANT STOICHIOMETRY re448 1161
left: HDAC7
interaction type: TRANSPORT
right: HDAC7

PARTICIPANT STOICHIOMETRY re407 500
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot P22612 108
organism: Homo sapiens

S621 RAF1 s742 sa680 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S621
feature location: S621 RAF1 s742 sa680 rs9 S621
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S621
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.46201537231871

Y G17 s1689 sa566 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y G17 s1689 sa566 rs1 Y
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.7742892784837644

S363 RSK1 2 s536 sa209 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S363
feature location: S363 RSK1 2 s536 sa209 rs1 S363
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=2.378634437717986
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S363

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__CXCL2-RIGHT__CXCL2-_re505
controller: NFKB1/RELA heterodimer

AKAP
type: ProteinReference
xref: P07184
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.AKAP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: A-kinase anchor protein 1, mitochondrial

PTHR46474:SF1
type: RelationshipXref
id: PTHR46474:SF1
db: PANTHER Family
relationship type: By Homology

Complex (GRB2/SOS1)
type: Complex
component stoichiometry: GRB2 @EGFR s887 sa277 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS1 s749 sa276 STOICHIOMETRY ID COMPLEX
component: SOS1
component: GRB2 @EGFR
feature: COMPLEX BINDING FEATURE s1925 csa11 261
feature: COMPLEX BINDING FEATURE s1925 csa11 263
cellular location: CELL

ITGB1
type: DnaRegionReference
member entity reference: Integrin beta-1
xref: G07277
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.ITGB1
comment: ENTITY_REFERENCE_NOTES=

Y438 CCK2R s1410 sa568 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y438
feature location: Y438 CCK2R s1410 sa568 rs5 Y438
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y438
comment: MODIFICATION_RESIDUE_ANGLE=4.421329661007988
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PARTICIPANT STOICHIOMETRY re293 564
type: Stoichiometry
physical entity: Galpha/sbeta/gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re293 567
type: Stoichiometry
physical entity: GalphaS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re293 568
type: Stoichiometry
physical entity: Gbeta/gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re293 565
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05771 43
xref: PTHR24356:SF158
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re293 566
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Y407 FAK1 s669 sa111 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y407
feature location: Y407 FAK1 s669 sa111 rs2 Y407
comment: MODIFICATION_RESIDUE_NAME=Y407
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.74

FOXO3
type: ProteinReference
xref: P07073
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.FOXO3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Forkhead box protein O3

MOB kinase activator 1A
type: DnaReference
xref: PTHR22599:SF30
organism: Homo sapiens

T202 MAPK1 s987 sa202 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T202
feature location: T202 MAPK1 s987 sa202 rs1 T202
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T202
comment: MODIFICATION_RESIDUE_ANGLE=0.76

uniprot P07947 23
type: UnificationXref
id: P07947
db: uniprot

cAMP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1532 sa838 478
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

p85 s885 sa298 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p85
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__Galpha_sbeta_gamma-_GTP-RIGHT__GDP-_GalphaS-_Gbeta_gamma-_re293
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re293 566
participant stoichiometry: PARTICIPANT STOICHIOMETRY re293 568
participant stoichiometry: PARTICIPANT STOICHIOMETRY re293 567
participant stoichiometry: PARTICIPANT STOICHIOMETRY re293 565
participant stoichiometry: PARTICIPANT STOICHIOMETRY re293 564
left: Galpha/sbeta/gamma
left: GTP
interaction type: DISSOCIATION
right: Gbeta/gamma
right: GDP
right: GalphaS

Y402 FAK2 s1598 sa886 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y402
feature location: Y402 FAK2 s1598 sa886 rs1 Y402
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.37
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y402

Dual specificity mitogen-activated protein kinase kinase 5
type: ProteinReference
xref: PTHR48013:SF9
xref: uniprot Q13163 14
organism: Homo sapiens

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__TAC1-RIGHT__TAC1-_re508
controller: AP1 (FOS+JUN)

Mitogen-activated protein kinase 7
type: ProteinReference
xref: PTHR24055:SF356
xref: uniprot Q13164 136
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re287 570
type: Stoichiometry
physical entity: CCK1R (inactive)
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__FAK1-RIGHT__FAK1-_re69
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 674
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 673
left: FAK1
interaction type: STATE_TRANSITION
right: FAK1

S721 RPTOR s643 sa312 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S721
feature location: S721 RPTOR s643 sa312 rs2 S721
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S721
comment: MODIFICATION_RESIDUE_ANGLE=5.5847024334941295

PLCgamma1
type: ProteinReference
xref: P07037
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PLC_gamma_1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

AKT1-PIP3
type: Complex
component stoichiometry: PI3,4,5 P3 s907 sa302 STOICHIOMETRY ID COMPLEX
component stoichiometry: AKT1 s908 sa303 STOICHIOMETRY ID COMPLEX
component: PI3,4,5 P3 s907 sa302
component: AKT1
feature: COMPLEX BINDING FEATURE s1939 csa22 331
feature: COMPLEX BINDING FEATURE s1939 csa22 333
cellular location: CELL

Y77 Pro CCK @ secretory granule s1192 sa500 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 Pro CCK @ secretory granule s1192 sa500 rs1 Y77
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4062112407013045
comment: MODIFICATION_RESIDUE_NAME=Y77

Paxillin
type: Protein
entity reference: Paxillin
feature: ACTIVE 13
feature: Y118 Paxillin s672 sa119 rs2
feature: Y31 Paxillin s672 sa119 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR24055:SF356
type: RelationshipXref
id: PTHR24055:SF356
db: PANTHER Family
relationship type: By Homology

CK1
type: ProteinReference
xref: P07049
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CK1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Casein kinase I isoform alpha

T69 ATF2 s990 sa754 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T69
feature location: T69 ATF2 s990 sa754 rs1 T69
comment: MODIFICATION_RESIDUE_ANGLE=0.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T69

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p52_SHC1-RIGHT__p52_SHC1-_re59
controller: PKCalpha

MAPKAP-K2
type: Protein
entity reference: MAPKAP K2 PROTEIN
feature: ACTIVE 13
feature: T222 MAPKAP K2 s1584 sa871 rs1
feature: S272 MAPKAP K2 s1584 sa871 rs2
feature: T334 MAPKAP K2 s1584 sa871 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CLU
type: Protein
entity reference: CLU
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot Q13153 159
xref: PTHR48015:SF20
organism: Homo sapiens

cAMP s1534 sa839 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

FAK2-SRC complex
type: Complex
component stoichiometry: FAK2 s1591 sa878 STOICHIOMETRY ID COMPLEX
component stoichiometry: SRC @Galphaq s1605 sa879 STOICHIOMETRY ID COMPLEX
component: SRC @Galphaq
component: FAK2
feature: COMPLEX BINDING FEATURE s1952 csa49 277
feature: COMPLEX BINDING FEATURE s1952 csa49 275
cellular location: CELL

S722 RPTOR s954 sa309 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S722
feature location: S722 RPTOR s954 sa309 rs3 S722
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.378634437717986
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S722

PARTICIPANT STOICHIOMETRY re287 569
type: Stoichiometry
physical entity: CCK1R (active)
stoichiometric coefficient: 1.0

S315 FOXO3 s1621 sa901 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S315
feature location: S315 FOXO3 s1621 sa901 rs1 S315
comment: MODIFICATION_RESIDUE_NAME=S315
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.71

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__Cytochrome_C-RIGHT__Cytochrome_C-_re633
controller: BAX

PARTICIPANT STOICHIOMETRY re536 1000
type: Stoichiometry
physical entity: RSK1/2
stoichiometric coefficient: 1.0

RHOA-GTP
type: Protein
entity reference: RHOA-GTP
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PRKD2
type: Protein
entity reference: PRKD2
feature: S710 PRKD2 s773 sa696 rs3
feature: S706 PRKD2 s773 sa696 rs2
feature: S876 PRKD2 s773 sa696 rs1
feature: S244 PRKD2 s773 sa696 rs6
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Ca_CaM
type: Complex
component stoichiometry: CaN s2014 sa1011 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s2013 sa1010 STOICHIOMETRY ID COMPLEX
component stoichiometry: CaM s2012 sa1009 STOICHIOMETRY ID COMPLEX
component: CaM
component: Ca2+
component: CaN
feature: ACTIVE 13
feature: COMPLEX BINDING FEATURE s2011 csa85 419
feature: COMPLEX BINDING FEATURE s2011 csa85 421
feature: COMPLEX BINDING FEATURE s2011 csa85 423
cellular location: CELL

Complex (GRB2/SOS1)
type: Complex
component stoichiometry: SOS1 s943 sa272 STOICHIOMETRY ID COMPLEX
component stoichiometry: GRB2 s942 sa271 STOICHIOMETRY ID COMPLEX
component: SOS1
component: GRB2 s942 sa271
feature: COMPLEX BINDING FEATURE s1924 csa9 259
feature: COMPLEX BINDING FEATURE s1924 csa9 257
cellular location: CELL

Y94 CCK s1911 sa947 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 CCK s1911 sa947 rs3 Y94
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.474173865666921
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y94

PTHR19384:SF63
type: RelationshipXref
id: PTHR19384:SF63
db: PANTHER Family
relationship type: By Homology

CXCL2
type: DnaRegion
entity reference: CXCL2
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Y397 FAK1 s776 sa285 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y397
feature location: Y397 FAK1 s776 sa285 rs1 Y397
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.47
comment: MODIFICATION_RESIDUE_NAME=Y397
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PTEN
type: Protein
entity reference: PTEN
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CCK1R
type: Protein
feature: ACTIVE 13
feature: S430 CCK1R s1672 sa775 rs4
feature: S264 CCK1R s1672 sa775 rs2
feature: S260 CCK1R s1672 sa775 rs1
feature: S307 CCK1R s1672 sa775 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y77 CCK s1780 sa949 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 CCK s1780 sa949 rs1 Y77
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3832305715485393
comment: MODIFICATION_RESIDUE_NAME=Y77

p60 SRC
type: Protein
entity reference: p60 SRC
feature: ACTIVE 13
feature: Y416 p60 SRC s1451 sa783 rs1
feature: Y527 p60 SRC s1451 sa783 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1451 sa783 402
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re423 1189
type: Stoichiometry
physical entity: MMP9
stoichiometric coefficient: 1.0

S256 FOXO1 s1620 sa899 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S256
feature location: S256 FOXO1 s1620 sa899 rs1 S256
comment: MODIFICATION_RESIDUE_NAME=S256
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3089902527502986

S505 PLA2 s1515 sa826 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S505
feature location: S505 PLA2 s1515 sa826 rs2 S505
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S505

IKBalpha
type: Protein
entity reference: IKBalpha
feature: S32 IKBalpha s844 sa252 rs1
feature: S36 IKBalpha s844 sa252 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s844 sa252 360
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

RPS6
type: Protein
entity reference: RPS6
feature: ACTIVE 13
feature: RPS6 s663 sa170 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S43 RAF1 s1336 sa692 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S43
feature location: S43 RAF1 s1336 sa692 rs6 S43
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.908388522052502
comment: MODIFICATION_RESIDUE_NAME=S43

S264 CCK1R s1672 sa449 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S264
feature location: S264 CCK1R s1672 sa449 rs2 S264
comment: MODIFICATION_RESIDUE_ANGLE=4.459733321203526
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S264

PARTICIPANT STOICHIOMETRY re423 1188
type: Stoichiometry
physical entity: MMP9
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__Gbeta_gamma-_Galpha_q_complex-RIGHT__Pi-_G_Protein_complex-_re612
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re612 837
participant stoichiometry: PARTICIPANT STOICHIOMETRY re612 836
participant stoichiometry: PARTICIPANT STOICHIOMETRY re612 834
participant stoichiometry: PARTICIPANT STOICHIOMETRY re612 835
left: Galpha q complex
left: Gbeta/gamma
interaction type: HETERODIMER_ASSOCIATION
right: Pi
right: G Protein complex

S744 PRKD1 s660 sa42 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S744
feature location: S744 PRKD1 s660 sa42 rs1 S744
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7813427511940191
comment: MODIFICATION_RESIDUE_NAME=S744

NFKB1 p50 s1681 sa327 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.78837880158871
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Migration
controller: Paxillin

S2448 mTOR s958 sa316 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S2448
feature location: S2448 mTOR s958 sa316 rs3 S2448
comment: MODIFICATION_RESIDUE_ANGLE=3.8000982565743886
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S2448

PARTICIPANT STOICHIOMETRY re178 856
type: Stoichiometry
physical entity: Conventional PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re587 797
type: Stoichiometry
physical entity: HRAS-GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re587 798
type: Stoichiometry
physical entity: AKT1-PIP3
stoichiometric coefficient: 1.0

S32 IKBalpha s1210 sa255 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S32
feature location: S32 IKBalpha s1210 sa255 rs1 S32
comment: MODIFICATION_RESIDUE_NAME=S32
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7

PARTICIPANT STOICHIOMETRY re112 1099
type: Stoichiometry
physical entity: mTORC1 complex
stoichiometric coefficient: 1.0

P07119
type: UnificationXref
id: P07119
db: PANTHER Pathway Component

P07118
type: UnificationXref
id: P07118
db: PANTHER Pathway Component

P07117
type: UnificationXref
id: P07117
db: PANTHER Pathway Component

P07116
type: UnificationXref
id: P07116
db: PANTHER Pathway Component

P07114
type: UnificationXref
id: P07114
db: PANTHER Pathway Component

P07113
type: UnificationXref
id: P07113
db: PANTHER Pathway Component

P07111
type: UnificationXref
id: P07111
db: PANTHER Pathway Component

Gastrin
type: ProteinReference
xref: uniprot P01350 36
xref: PTHR19309:SF0
organism: Homo sapiens

DISSOCIATION
type: InteractionVocabulary

STATE_TRANSITION_LEFT__RSK1_2-RIGHT__RSK1_2-_re145
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re145 981
participant stoichiometry: PARTICIPANT STOICHIOMETRY re145 982
left: RSK1/2
interaction type: STATE_TRANSITION
right: RSK1/2

STATE_TRANSITION_LEFT__MAP3K14-RIGHT__MAP3K14-_re37
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 813
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 814
left: MAP3K14
interaction type: STATE_TRANSITION
right: MAP3K14

STATE_TRANSITION_LEFT__RSK1_2-RIGHT__RSK1_2-_re144
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re144 983
participant stoichiometry: PARTICIPANT STOICHIOMETRY re144 984
left: RSK1/2
interaction type: STATE_TRANSITION
right: RSK1/2

S473 AKT1 s905 sa305 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S473
feature location: S473 AKT1 s905 sa305 rs2 S473
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S473
comment: MODIFICATION_RESIDUE_ANGLE=5.615596868291756

STATE_TRANSITION_LEFT__RSK1_2-RIGHT__RSK1_2-_re146
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re146 980
participant stoichiometry: PARTICIPANT STOICHIOMETRY re146 979
left: RSK1/2
interaction type: STATE_TRANSITION
right: RSK1 2 s539 sa214

RICTOR s960 sa318 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RICTOR
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__RSK1_2-RIGHT__RSK1_2-_re148
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re148 976
participant stoichiometry: PARTICIPANT STOICHIOMETRY re148 975
left: RSK1 2 s539 sa214
interaction type: STATE_TRANSITION
right: RSK1/2

Y416 YES1 s1609 sa890 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 YES1 s1609 sa890 rs1 Y416
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7450763826873115

uniprot Q02156 135
type: UnificationXref
id: Q02156
db: uniprot

uniprot P60484 67
type: UnificationXref
id: P60484
db: uniprot

T202 MAPK1 3 s827 sa217 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T202
feature location: T202 MAPK1 3 s827 sa217 rs3 T202
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T202
comment: MODIFICATION_RESIDUE_ANGLE=0.8054181165820891

RAC1-GDP
type: Protein
entity reference: RAC1-GDP
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y881 FAK2 s1203 sa519 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y881
feature location: Y881 FAK2 s1203 sa519 rs4 Y881
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5
comment: MODIFICATION_RESIDUE_NAME=Y881

PAI2
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.PAI2
comment: ENTITY_REFERENCE_NOTES=

P07106
type: UnificationXref
id: P07106
db: PANTHER Pathway Component

Y416 SRC @Galphaq s1769 sa881 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 SRC @Galphaq s1769 sa881 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789

P07109
type: UnificationXref
id: P07109
db: PANTHER Pathway Component

P07108
type: UnificationXref
id: P07108
db: PANTHER Pathway Component

beta-catenin
type: Protein
entity reference: beta-catenin
feature: T41 beta catenin s1274 sa636 rs4
feature: S45 beta catenin s1274 sa636 rs3
feature: S33 beta catenin s1274 sa636 rs2
feature: S37 beta catenin s1274 sa636 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

MAPK1/3
type: Protein
entity reference: MAPK1/3
feature: Y204 MAPK1 3 s1788 sa954 rs4
feature: T202 MAPK1 3 s1788 sa954 rs3

P07103
type: UnificationXref
id: P07103
db: PANTHER Pathway Component

P07105
type: UnificationXref
id: P07105
db: PANTHER Pathway Component

TRANSPORT_LEFT__NFKB_RELA_heterodimer-RIGHT__NFKB1_RELA_heterodimer-_re529
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re529 1034
participant stoichiometry: PARTICIPANT STOICHIOMETRY re529 1033
left: NFKB/RELA heterodimer
interaction type: TRANSPORT
right: NFKB1/RELA heterodimer

PARTICIPANT STOICHIOMETRY re178 857
type: Stoichiometry
physical entity: PKCbeta
stoichiometric coefficient: 1.0

RHEB-GTP
type: Protein
entity reference: RHEB-GTP
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

P07100
type: UnificationXref
id: P07100
db: PANTHER Pathway Component

T440 CCK2R s1235 sa558 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T440
feature location: T440 CCK2R s1235 sa558 rs8 T440
comment: MODIFICATION_RESIDUE_ANGLE=5.06610690323832
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T440

KNOWN_TRANSITION_OMITTED_LEFT__RAF-RIGHT__B_Raf-_re175
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re175 866
participant stoichiometry: PARTICIPANT STOICHIOMETRY re175 867
left: RAF
interaction type: KNOWN_TRANSITION_OMITTED
right: B-Raf

PKCtheta
type: Protein
entity reference: PKCtheta
feature: ACTIVE 13
feature: T538 PKCtheta s1720 sa643 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

UNKNOWN_CATALYSIS
type: TemplateReactionRegulation
xref: UNKNOWN CATALYSIS
controlled: TRANSCRIPTION_LEFT__HBEGF-RIGHT__HBEGF-_re240
controller: AP1 (FOS+JUN)

FOS
type: Protein
entity reference: FOS
feature: S133 FOS s1858 sa234 rs5
feature: ACTIVE 13
feature: S70 FOS s1858 sa234 rs4
feature: S374 FOS s1858 sa234 rs6
feature: S42 FOS s1858 sa234 rs3
feature: S32 FOS s1858 sa234 rs2
feature: S21 FOS s1858 sa234 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y317 p52 SHC1 s711 sa104 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y317
feature location: Y317 p52 SHC1 s711 sa104 rs1 Y317
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y317
comment: MODIFICATION_RESIDUE_ANGLE=0.8063981142904283

PARTICIPANT STOICHIOMETRY re527 1040
type: Stoichiometry
physical entity: FAK1-SRC complex
stoichiometric coefficient: 1.0

P07138
type: UnificationXref
id: P07138
db: PANTHER Pathway Component

TPC1/2
type: Protein
entity reference: TPC1/2
feature: ACTIVE 13
cellular location: Lysosome
comment: SPECIES_TYPE=PROTEIN

P07137
type: UnificationXref
id: P07137
db: PANTHER Pathway Component

P07136
type: UnificationXref
id: P07136
db: PANTHER Pathway Component

P07135
type: UnificationXref
id: P07135
db: PANTHER Pathway Component

P07139
type: UnificationXref
id: P07139
db: PANTHER Pathway Component

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P22694 109
organism: Homo sapiens

P07134
type: UnificationXref
id: P07134
db: PANTHER Pathway Component

P07133
type: UnificationXref
id: P07133
db: PANTHER Pathway Component

STAT3
type: Protein
entity reference: STAT3
feature: Y705 STAT3 s1785 sa325 rs1
feature: ACTIVE 13
feature: Y725 STAT3 s1785 sa325 rs2

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__IP3R-RIGHT__IP3R-_re3
control type: ACTIVATION
controller: Glucose

P07131
type: UnificationXref
id: P07131
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re148 976
type: Stoichiometry
physical entity: RSK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re148 975
type: Stoichiometry
physical entity: RSK1 2 s539 sa214
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__NFKB1_RELA_heterodimer-RIGHT__BIRC3-_re615
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re615 828
participant stoichiometry: PARTICIPANT STOICHIOMETRY re615 829
left: NFKB1/RELA heterodimer
interaction type: STATE_TRANSITION
right: BIRC3

Y1068 EGFR s727 sa266 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y1068
feature location: Y1068 EGFR s727 sa266 rs8 Y1068
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.757007227267995
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y1068

PKCalpha
type: ProteinReference
xref: P07095
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PKC_alpha_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein kinase C alpha type

ELAV-like protein 1
type: ProteinReference
xref: PTHR10352:SF13
xref: uniprot Q15717 149
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re527 1038
type: Stoichiometry
physical entity: p60 SRC
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__CHGA-RIGHT__CHGA-_re232
type: TemplateReaction
product: CHGA
xref: TRANSCRIPTION
participant: CHGA
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

MAPK3
type: Protein
entity reference: MAPK3
feature: Y204 MAPK3 s830 sa203 rs2
feature: T202 MAPK3 s830 sa203 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re527 1039
type: Stoichiometry
physical entity: FAK1
stoichiometric coefficient: 1.0

S244 PRKD2 s774 sa735 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S244
feature location: S244 PRKD2 s774 sa735 rs6 S244
comment: MODIFICATION_RESIDUE_NAME=S244
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.822805346332478

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RYR1_2_3-RIGHT__RYR1_2_3-_re515
controller: FK506

S442 CCK2R s1410 sa568 rs10
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S442
feature location: S442 CCK2R s1410 sa568 rs10 S442
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=6.097097937454755
comment: MODIFICATION_RESIDUE_NAME=S442

PARTICIPANT STOICHIOMETRY re332 553
type: Stoichiometry
physical entity: active CCK2R beta arrestin complex s1687 csa54
stoichiometric coefficient: 1.0

P07125
type: UnificationXref
id: P07125
db: PANTHER Pathway Component

Myocyte-specific enhancer factor 2C
type: ProteinReference
xref: uniprot Q06413 160
organism: Homo sapiens

STAT3
type: Protein
entity reference: STAT3
feature: Y725 STAT3 s676 sa323 rs2
feature: ACTIVE 13
feature: Y705 STAT3 s676 sa323 rs1

BAX s795 sa143 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 2.0

P07127
type: UnificationXref
id: P07127
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re332 554
type: Stoichiometry
physical entity: active CCK2R/Beta-arrestin complex
stoichiometric coefficient: 1.0

P07126
type: UnificationXref
id: P07126
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re75 655
type: Stoichiometry
physical entity: RHOA-GDP
stoichiometric coefficient: 1.0

P07129
type: UnificationXref
id: P07129
db: PANTHER Pathway Component

P07128
type: UnificationXref
id: P07128
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re75 653
type: Stoichiometry
physical entity: RHOA-GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re75 654
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HSP27-RIGHT__HSP27-_re574
controller: MAPKAP-K2

P07121
type: UnificationXref
id: P07121
db: PANTHER Pathway Component

Y527 SRC @Galphaq s718 sa94 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 SRC @Galphaq s718 sa94 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.585857905576321
comment: MODIFICATION_RESIDUE_NAME=Y527

P07123
type: UnificationXref
id: P07123
db: PANTHER Pathway Component

CCK-58
type: Protein
entity reference: CCK-58
feature: ACTIVE 13
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__HuR-RIGHT__HuR-_re428
controller: p38MAPK s998 sa227

uniprot P35568 45
type: UnificationXref
id: P35568
db: uniprot

CCK-8
type: ProteinReference
xref: P07226
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CCK-8
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P06307

PARTICIPANT STOICHIOMETRY re130 1031
type: Stoichiometry
physical entity: SNAI1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re130 1032
type: Stoichiometry
physical entity: SNAI1
stoichiometric coefficient: 1.0

uniprot P56945 44
type: UnificationXref
id: P56945
db: uniprot

Y G34 Gly s7 sa80 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y G34 Gly s7 sa80 rs1 Y
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.715273327379819

S437 CCK2R s1369 sa563 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S437
feature location: S437 CCK2R s1369 sa563 rs4 S437
comment: MODIFICATION_RESIDUE_NAME=S437
comment: MODIFICATION_RESIDUE_ANGLE=3.6969103423572474
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

TRANSCRIPTION
type: RelationshipTypeVocabulary

MAP2K5
type: ProteinReference
xref: P07160
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAP2K5
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dual specificity mitogen-activated protein kinase kinase 5

SP3
type: ProteinReference
xref: P07041
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.SP3
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Transcription factor Sp3

DISSOCIATION_LEFT__c_RAF_14_3_3_complex-RIGHT__RAF1-_14_3_3_beta_alpha-_re519
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re519 1074
participant stoichiometry: PARTICIPANT STOICHIOMETRY re519 1072
participant stoichiometry: PARTICIPANT STOICHIOMETRY re519 1073
left: c-RAF/14-3-3 complex
interaction type: DISSOCIATION
right: 14-3-3 beta/alpha
right: RAF1

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Migration
controller: PAI1

CD38
type: Protein
entity reference: CD38
feature: ACTIVE 13
cellular location: Lysosome
comment: SPECIES_TYPE=PROTEIN

Y472 PLCgamma1 s716 sa18 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y472
feature location: Y472 PLCgamma1 s716 sa18 rs1 Y472
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y472
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8080320590199856

SNAI1
type: ProteinReference
xref: P07055
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.SNAI1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Zinc finger protein SNAI1

mTOR s958 sa316 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mTOR
stoichiometric coefficient: 1.0

PTHR11920:SF228
type: RelationshipXref
id: PTHR11920:SF228
db: PANTHER Family
relationship type: By Homology

T268 9 RAF1 s1721 sa694 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T268 9
feature location: T268 9 RAF1 s1721 sa694 rs7 T268 9
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T268/9
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CaM
type: Protein
entity reference: CaM
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAP2K1-RIGHT__MAP2K1-_re140
controller: A-Raf

KNOWN_TRANSITION_OMITTED_LEFT__Novel_PKC-RIGHT__PKCepsilon-_re17
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 901
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 902
left: Novel PKC
interaction type: KNOWN_TRANSITION_OMITTED
right: PKCepsilon

ELK1
type: Protein
entity reference: ELK1
feature: ACTIVE 13
feature: S383 ELK1 s198 sa334 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re20 870
type: Stoichiometry
physical entity: Atypical PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 871
type: Stoichiometry
physical entity: Atypical PKC
stoichiometric coefficient: 1.0

S21 FOS s205 sa337 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S21
feature location: S21 FOS s205 sa337 rs1 S21
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S21
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.348702615819714

PARTICIPANT STOICHIOMETRY re638 732
type: Stoichiometry
physical entity: YES1
stoichiometric coefficient: 1.0

Prostaglandin G/H synthase 2
type: ProteinReference
xref: uniprot P35354 145
xref: PTHR11903:SF8
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re638 731
type: Stoichiometry
physical entity: YES1
stoichiometric coefficient: 1.0

T389 p70S6K1 s650 sa171 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T389
feature location: T389 p70S6K1 s650 sa171 rs1 T389
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T389
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.71

PARTICIPANT STOICHIOMETRY re562 899
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re562 898
type: Stoichiometry
physical entity: BCL2
stoichiometric coefficient: 1.0

I441 CCK2R s1369 sa563 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY I441
feature location: I441 CCK2R s1369 sa563 rs9 I441
comment: MODIFICATION_RESIDUE_ANGLE=5.567911979799767
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=I441

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SRC_@Galphaq-RIGHT__SRC_@Galphaq-_re52
controller: Galpha q complex

S264 CCK1R s1483 sa454 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S264
feature location: S264 CCK1R s1483 sa454 rs2 S264
comment: MODIFICATION_RESIDUE_ANGLE=4.459733321203526
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S264

BAD
type: Protein
entity reference: BAD
feature: S136 BAD s791 sa149 rs2
feature: S112 BAD s791 sa149 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S749 RSK1 2 s537 sa211 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S749
feature location: S749 RSK1 2 s537 sa211 rs6 S749
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=S749
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.408013221559381

TRANSPORT_LEFT__NFAT1-RIGHT__NFAT1-_re670
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re670 596
participant stoichiometry: PARTICIPANT STOICHIOMETRY re670 595
left: NFAT1
interaction type: TRANSPORT
right: NFAT1

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Anti-apoptosis
controller: CLU

MYC
type: DnaRegion
entity reference: MYC
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Gastric mucosa differentiation
controller: VMAT2

PTHR10177:SF67
type: RelationshipXref
id: PTHR10177:SF67
db: PANTHER Family
relationship type: By Homology

AKT1-PIP3
type: Complex
component stoichiometry: AKT1 s905 sa305 STOICHIOMETRY ID COMPLEX
component stoichiometry: PI3,4,5 P3 s912 sa304 STOICHIOMETRY ID COMPLEX
component: AKT1
component: PI3,4,5-P3
feature: COMPLEX BINDING FEATURE s1938 csa23 327
feature: COMPLEX BINDING FEATURE s1938 csa23 329
cellular location: CELL

p46SHC1-GRB2-SOS1
type: Complex
component stoichiometry: GRB2 s948 sa280 STOICHIOMETRY ID COMPLEX
component stoichiometry: p46 SHC1 s947 sa279 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS1 s910 sa278 STOICHIOMETRY ID COMPLEX
component: GRB2
component: p46 SHC1
component: SOS1
feature: COMPLEX BINDING FEATURE s1927 csa12 413
feature: COMPLEX BINDING FEATURE s1927 csa12 411
feature: COMPLEX BINDING FEATURE s1927 csa12 409
cellular location: CELL

uniprot Q9ULQ1 53
type: UnificationXref
id: Q9ULQ1
db: uniprot

S212 PRAS40 s648 sa176 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S212
feature location: S212 PRAS40 s648 sa176 rs3 S212
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3412474663214593
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S212

PARTICIPANT STOICHIOMETRY re56 716
type: Stoichiometry
physical entity: p46 SHC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re56 715
type: Stoichiometry
physical entity: SHC1
stoichiometric coefficient: 1.0

Y341 RAF1 s1721 sa694 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y341
feature location: Y341 RAF1 s1721 sa694 rs2 Y341
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y341
comment: MODIFICATION_RESIDUE_ANGLE=0.813361255902311

p85
type: Protein
entity reference: p85
feature: COMPLEX PARTICIPANT BINDING FEATURE s934 sa296 206
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__RHOA_GDP-_GTP-RIGHT__GDP-_RHOA_GTP-_re74
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re74 657
participant stoichiometry: PARTICIPANT STOICHIOMETRY re74 656
participant stoichiometry: PARTICIPANT STOICHIOMETRY re74 658
participant stoichiometry: PARTICIPANT STOICHIOMETRY re74 659
left: RHOA-GDP
left: GTP
interaction type: STATE_TRANSITION
right: GDP
right: RHOA-GTP

uniprot P10398 173
type: UnificationXref
id: P10398
db: uniprot

TRANSCRIPTION_LEFT__CALCA-RIGHT__CALCA-_re503
type: TemplateReaction
product: CALCA s1845 sa796
xref: TRANSCRIPTION
participant: CALCA
participant: CALCA s1845 sa796
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

KNOWN_TRANSITION_OMITTED_LEFT__SHC1-RIGHT__p52_SHC1-_re58
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re58 710
participant stoichiometry: PARTICIPANT STOICHIOMETRY re58 709
left: SHC1
interaction type: KNOWN_TRANSITION_OMITTED
right: p52 SHC1

PKCbeta
type: ProteinReference
xref: P07177
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PKC_beta_
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein kinase C beta type

T246 PRAS40 s647 sa173 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T246
feature location: T246 PRAS40 s647 sa173 rs2 T246
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T246
comment: MODIFICATION_RESIDUE_ANGLE=5.5644565530974495

STATE_TRANSITION_LEFT__A_Raf-RIGHT__A_Raf-_re378
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re378 1210
participant stoichiometry: PARTICIPANT STOICHIOMETRY re378 1211
left: A-Raf
interaction type: STATE_TRANSITION
right: A-Raf

uniprot P40763 146
type: UnificationXref
id: P40763
db: uniprot

uniprot P21817 25
type: UnificationXref
id: P21817
db: uniprot

STATE_TRANSITION_LEFT__SHC-RIGHT__SHC1-_re524
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re524 1046
participant stoichiometry: PARTICIPANT STOICHIOMETRY re524 1045
left: SHC
interaction type: STATE_TRANSITION
right: SHC1

mLST8
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s916 sa317 314
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p46_SHC1-RIGHT__p46_SHC1-_re60
controller: SRC @Galphaq

KNOWN_TRANSITION_OMITTED_LEFT__IRS1-RIGHT__IRS1-_re100
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re100 1146
participant stoichiometry: PARTICIPANT STOICHIOMETRY re100 1147
left: IRS1
interaction type: KNOWN_TRANSITION_OMITTED
right: IRS1

T211 MAP2K6 s997 sa224 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T211
feature location: T211 MAP2K6 s997 sa224 rs2 T211
comment: MODIFICATION_RESIDUE_NAME=T211
comment: MODIFICATION_RESIDUE_ANGLE=5.499324126489373
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

T183 MAPK8 10 s665 sa222 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T183
feature location: T183 MAPK8 10 s665 sa222 rs1 T183
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T183
comment: MODIFICATION_RESIDUE_ANGLE=0.8048507494877875

RHOA-GDP
type: Protein
entity reference: RHOA-GDP
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Gbeta gamma s91 sa576 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta/gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re556 935
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re556 936
type: Stoichiometry
physical entity: IP3R
stoichiometric coefficient: 1.0

PANTHER Pathway P06959 1
type: UnificationXref
id: P06959
db: PANTHER Pathway

PARTICIPANT STOICHIOMETRY re64 694
type: Stoichiometry
physical entity: Complex (GRB2/SOS1)
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__CXCL2-RIGHT__CXCL2-_re506
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re506 1108
participant stoichiometry: PARTICIPANT STOICHIOMETRY re506 1107
left: CXCL2
interaction type: TRANSPORT
right: CXCL2

PARTICIPANT STOICHIOMETRY re64 693
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re64 692
type: Stoichiometry
physical entity: SOS1
stoichiometric coefficient: 1.0

CCND1
type: DnaRegionReference
member entity reference: G1/S-specific cyclin-D1
xref: G07280
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.CCND1
comment: ENTITY_REFERENCE_NOTES=

HETERODIMER_ASSOCIATION_LEFT__IL8-_HuR-RIGHT__HuR_IL8-_re444
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re444 1166
participant stoichiometry: PARTICIPANT STOICHIOMETRY re444 1168
participant stoichiometry: PARTICIPANT STOICHIOMETRY re444 1167
left: HuR
left: IL8
interaction type: HETERODIMER_ASSOCIATION
right: HuR-IL8

S221 PRAS40 s648 sa176 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 PRAS40 s648 sa176 rs4 S221
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221
comment: MODIFICATION_RESIDUE_ANGLE=3.856865980969612

JUN
type: ProteinReference
xref: P07114
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.JUN
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Transcription factor AP-1

TRANSLATION_LEFT__HuR-RIGHT__HuR-_re440
type: TemplateReaction
product: HuR
xref: TRANSLATION
participant: HuR
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

T41 beta catenin s1273 sa637 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T41
feature location: T41 beta catenin s1273 sa637 rs4 T41
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T41
comment: MODIFICATION_RESIDUE_ANGLE=2.3739822534748654

COX2
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.COX2
comment: ENTITY_REFERENCE_NOTES=

GDP s736 sa493 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CDC42_GTP-RIGHT__Pi-_CDC42_GDP-_re79
controller: GAP

PKA-R2
type: Complex
component stoichiometry: cAMP s1534 sa839 STOICHIOMETRY ID COMPLEX
component stoichiometry: PKA R2alpha beta s1528 sa834 STOICHIOMETRY ID COMPLEX
component: cAMP
component: PKA-R2alpha/beta
feature: COMPLEX BINDING FEATURE s1958 csa68 459
feature: COMPLEX BINDING FEATURE s1958 csa68 461
cellular location: CELL

PARTICIPANT STOICHIOMETRY re526 1042
type: Stoichiometry
physical entity: SHC2
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FOS-RIGHT__FOS-_re621
controller: PP2A

PARTICIPANT STOICHIOMETRY re248 705
type: Stoichiometry
physical entity: TFF1
stoichiometric coefficient: 1.0

BAD
type: Protein
entity reference: BAD
feature: S136 BAD s1612 sa892 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1612 sa892 222
feature: S112 BAD s1612 sa892 rs1
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re248 706
type: Stoichiometry
physical entity: TFF1
stoichiometric coefficient: 1.0

S494 RAF1 s1721 sa694 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S494
feature location: S494 RAF1 s1721 sa694 rs5 S494
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.018263774283071
comment: MODIFICATION_RESIDUE_NAME=S494

PARTICIPANT STOICHIOMETRY re526 1041
type: Stoichiometry
physical entity: SHC
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re478 1085
type: Stoichiometry
physical entity: Progastrin @Golgi
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__CCK-RIGHT__CCK_33-_re496
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re496 1019
participant stoichiometry: PARTICIPANT STOICHIOMETRY re496 1020
left: CCK
interaction type: STATE_TRANSITION
right: CCK-33

go GO:0005739 8
type: UnificationXref
id: GO:0005739
db: go

PARTICIPANT STOICHIOMETRY re478 1084
type: Stoichiometry
physical entity: Progastrin @ER - Golgi
stoichiometric coefficient: 1.0

GRB2
type: Protein
entity reference: GRB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s948 sa280 414
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

MAPK3
type: ProteinReference
xref: P07119
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAPK3
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mitogen-activated protein kinase 3

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FOXO3-RIGHT__FOXO3-_re582
controller: AKT1-PIP3

Gastric mucosa differentiation
type: Pathway

CCK2R s1688 sa565 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CCK2R
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRKD2-RIGHT__PRKD2-_re446
controller: CK1delta/epsilon

PARTICIPANT STOICHIOMETRY re492 1026
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

S748 PRKD1 s662 sa41 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S748
feature location: S748 PRKD1 s662 sa41 rs2 S748
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S748
comment: MODIFICATION_RESIDUE_ANGLE=5.553194421623227

Galpha13 s139 sa574 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galpha13
stoichiometric coefficient: 1.0

uniprot P29475 134
type: UnificationXref
id: P29475
db: uniprot

PARTICIPANT STOICHIOMETRY re492 1025
type: Stoichiometry
physical entity: CCK-22
stoichiometric coefficient: 1.0

Y416 p60 SRC s1451 sa783 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 p60 SRC s1451 sa783 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.8018247916515125

MAP2K4
type: Protein
entity reference: MAP2K4
feature: T261 MAP2K4 s996 sa220 rs2
feature: S257 MAP2K4 s996 sa220 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S338 RAF1 s731 sa687 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S338
feature location: S338 RAF1 s731 sa687 rs1 S338
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S338
comment: MODIFICATION_RESIDUE_ANGLE=1.5707963267948966

VMAT2
type: ProteinReference
xref: P07137
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.VMAT2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Synaptic vesicular amine transporter

PARTICIPANT STOICHIOMETRY re408 497
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re408 498
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__p85-_p110-RIGHT__PI3K_Class_I-_re101
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re101 1143
participant stoichiometry: PARTICIPANT STOICHIOMETRY re101 1141
participant stoichiometry: PARTICIPANT STOICHIOMETRY re101 1142
left: p110
left: p85
interaction type: HETERODIMER_ASSOCIATION
right: PI3K Class I

TRANSPORT_LEFT__EGR1-RIGHT__EGR1-_re630
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re630 752
participant stoichiometry: PARTICIPANT STOICHIOMETRY re630 751
left: EGR1
interaction type: TRANSPORT
right: EGR1

PKCalpha
type: Protein
entity reference: PKCalpha
feature: S657 PKCalpha s1824 sa17 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re72 662
type: Stoichiometry
physical entity: CAS-CRK complex
stoichiometric coefficient: 1.0

Galpha13
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s135 sa577 194
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S43 RAF1 s156 sa686 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S43
feature location: S43 RAF1 s156 sa686 rs6 S43
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.908388522052502
comment: MODIFICATION_RESIDUE_NAME=S43

PARTICIPANT STOICHIOMETRY re72 661
type: Stoichiometry
physical entity: CRK
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__cAMP-RIGHT__s785-_re299
controller: PDE

PARTICIPANT STOICHIOMETRY re72 660
type: Stoichiometry
physical entity: CAS
stoichiometric coefficient: 1.0

S260 CCK1R s1672 sa449 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S260
feature location: S260 CCK1R s1672 sa449 rs1 S260
comment: MODIFICATION_RESIDUE_NAME=S260
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8807084252156057

PARTICIPANT STOICHIOMETRY re99 577
type: Stoichiometry
physical entity: IRS1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__p38MAPK-RIGHT__p38MAPK-_re155
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re155 944
participant stoichiometry: PARTICIPANT STOICHIOMETRY re155 943
left: p38MAPK
interaction type: STATE_TRANSITION
right: p38MAPK s998 sa227

PARTICIPANT STOICHIOMETRY re60 701
type: Stoichiometry
physical entity: p46 SHC1
stoichiometric coefficient: 1.0

GRB2
type: Protein
entity reference: GRB2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re50 729
type: Stoichiometry
physical entity: HBEGF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re60 702
type: Stoichiometry
physical entity: p46 SHC1
stoichiometric coefficient: 1.0

MEF2B
type: ProteinReference
xref: P07075
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MEF2B
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Myocyte-specific enhancer factor 2B

PARTICIPANT STOICHIOMETRY re99 578
type: Stoichiometry
physical entity: IRS1
stoichiometric coefficient: 1.0

T443 CCK2R s1235 sa558 rs11
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T443
feature location: T443 CCK2R s1235 sa558 rs11 T443
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T443
comment: MODIFICATION_RESIDUE_ANGLE=0.25278736068041796

STATE_TRANSITION_LEFT__Pro_HBEGF-RIGHT___HBEGF-_re49
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re49 759
participant stoichiometry: PARTICIPANT STOICHIOMETRY re49 760
left: Pro HBEGF
interaction type: STATE_TRANSITION
right: HBEGF

PRKD1
type: Protein
entity reference: PRKD1
feature: S748 PRKD1 s660 sa42 rs2
feature: S744 PRKD1 s660 sa42 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

SRC @Galphaq
type: Protein
entity reference: SRC @Galphaq
feature: Y416 SRC @Galphaq s1605 sa879 rs1
feature: ACTIVE 13
feature: Y527 SRC @Galphaq s1605 sa879 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1605 sa879 278
feature: Y418 SRC @Galphaq s1605 sa879 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re567 886
type: Stoichiometry
physical entity: MCL1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re50 730
type: Stoichiometry
physical entity: HBEGF
stoichiometric coefficient: 1.0

uniprot Q05193 83
type: UnificationXref
id: Q05193
db: uniprot

PARTICIPANT STOICHIOMETRY re567 887
type: Stoichiometry
physical entity: MCL1
stoichiometric coefficient: 1.0

uniprot P25963 172
type: UnificationXref
id: P25963
db: uniprot

PARTICIPANT STOICHIOMETRY re369 506
type: Stoichiometry
physical entity: GSK3beta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re369 505
type: Stoichiometry
physical entity: GSK3beta
stoichiometric coefficient: 1.0

BCL2L1
type: Protein
entity reference: BCL2L1
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s801 sa292 254
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

SHC1 @EGFR
type: Protein
entity reference: SHC1 @EGFR
feature: Y317 SHC1 @EGFR s892 sa268 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s892 sa268 340
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y527 p62 SRC s881 sa98 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 p62 SRC s881 sa98 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y527
comment: MODIFICATION_RESIDUE_ANGLE=5.506919680565829

Complex (HBEGF/EGFR)
type: Complex
component stoichiometry: HBEGF s874 sa267 STOICHIOMETRY ID COMPLEX
component: HBEGF
component: EGFR
feature: COMPLEX BINDING FEATURE s1923 csa7 231
feature: COMPLEX BINDING FEATURE s1923 csa7 233
cellular location: CELL

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HRAS_GDP-RIGHT__HRAS_GTP-_re523
controller: FAK2-SRC-CRK complex

PARTICIPANT STOICHIOMETRY re202 903
type: Stoichiometry
physical entity: MEF2C
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re202 904
type: Stoichiometry
physical entity: MEF2
stoichiometric coefficient: 1.0

IKKgamma s1812 sa261 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: IKKgamma
stoichiometric coefficient: 1.0

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
xref: PTHR44329:SF22
xref: uniprot P04049 96
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAP2K1-RIGHT__MAP2K1-_re140
controller: B-Raf

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__MMP9-RIGHT__MMP9-_re420
control type: INHIBITION
controller: MEN1

Y390 CCK2R s1235 sa558 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y390
feature location: Y390 CCK2R s1235 sa558 rs1 Y390
comment: MODIFICATION_RESIDUE_ANGLE=2.4010743852436276
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y390

ACTIVE 13
type: EntityFeature
comment: Active state

Galpha q
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s686 sa248 288
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

RAF1
type: Protein
entity reference: RAF1
feature: S497 9 RAF1 s742 sa680 rs8
feature: S43 RAF1 s742 sa680 rs6
feature: S621 RAF1 s742 sa680 rs9
feature: Y341 RAF1 s742 sa680 rs2
feature: T268 9 RAF1 s742 sa680 rs7
feature: S338 RAF1 s742 sa680 rs1
feature: T491 RAF1 s742 sa680 rs4
feature: S494 RAF1 s742 sa680 rs5
feature: S259 RAF1 s742 sa680 rs3
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

PRKD2
type: Protein
entity reference: PRKD2
feature: S244 PRKD2 s1820 sa695 rs6
feature: S706 PRKD2 s1820 sa695 rs2
feature: S710 PRKD2 s1820 sa695 rs3
feature: S876 PRKD2 s1820 sa695 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

MAP2K2
type: ProteinReference
xref: P07121
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAP2K2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2

Y94 CCK GRR s877 sa501 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 CCK GRR s877 sa501 rs3 Y94
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.483571792408428
comment: MODIFICATION_RESIDUE_NAME=Y94

GRB2
type: Protein
entity reference: GRB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s949 sa283 252
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

L-Citrulline
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

MAPK1
type: ProteinReference
xref: P07166
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAPK1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mitogen-activated protein kinase 1

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

PLCbeta
type: Protein
feature: PLCbeta s1692 sa639 rs1
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

s1792
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=DEGRADED

RELA (p65)
type: Protein
feature: RELA p65 s1884 sa974 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1884 sa974 306
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 107
organism: Homo sapiens

CREB1
type: Protein
entity reference: CREB1
feature: ACTIVE 13
feature: S133 CREB1 s188 sa332 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

MAPK7 s1971 sa989 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAPK7
stoichiometric coefficient: 2.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62873 78
organism: Homo sapiens

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot Q14643 155
xref: PTHR13715:SF52
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re563 893
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 2.0

CALCA
type: DnaRegion
entity reference: CALCA
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

TFF1
type: DnaRegionReference
member entity reference: HGNC_11755
xref: G07287
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.TFF1
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re563 892
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 1.0

S33 beta catenin s1273 sa637 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S33
feature location: S33 beta catenin s1273 sa637 rs2 S33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7304919088134321
comment: MODIFICATION_RESIDUE_NAME=S33

IL8
type: Protein
entity reference: IL8
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

mTOR s924 sa308 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mTOR
stoichiometric coefficient: 1.0

Pro-caspase-3
type: Protein
entity reference: Pro-caspase-3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAP2K6-RIGHT__MAP2K6-_re151
controller: MAP3K11

PARTICIPANT STOICHIOMETRY re541 970
type: Stoichiometry
physical entity: MCL1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p70S6K1-RIGHT__p70S6K1-_re123
controller: mTORC1 complex

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__CCND1-RIGHT__CCND1-_re421
controller: CREB1

HETERODIMER_ASSOCIATION_LEFT__p60_SRC-_FAK1-RIGHT__FAK1_SRC_complex-_re527
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re527 1039
participant stoichiometry: PARTICIPANT STOICHIOMETRY re527 1040
participant stoichiometry: PARTICIPANT STOICHIOMETRY re527 1038
left: p60 SRC
left: FAK1
interaction type: HETERODIMER_ASSOCIATION
right: FAK1-SRC complex

PARTICIPANT STOICHIOMETRY re104 1132
type: Stoichiometry
physical entity: PI4,5-P2
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__BAD_BCL2L1_heterodimer-RIGHT__BAD_BCL2L1_heterodimer-_re578
controller: PAK1

PARTICIPANT STOICHIOMETRY re104 1131
type: Stoichiometry
physical entity: PI3,4,5-P3
stoichiometric coefficient: 1.0

S218 MAP2K1 s821 sa207 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S218
feature location: S218 MAP2K1 s821 sa207 rs1 S218
comment: MODIFICATION_RESIDUE_ANGLE=5.577710244558395
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S218

PARTICIPANT STOICHIOMETRY re541 969
type: Stoichiometry
physical entity: MCL1
stoichiometric coefficient: 1.0

Y579 FAK2 s1204 sa520 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y579
feature location: Y579 FAK2 s1204 sa520 rs2 Y579
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y579
comment: MODIFICATION_RESIDUE_ANGLE=3.84

ATF2
type: Protein
entity reference: ATF2 PROTEIN
feature: T71 ATF2 s990 sa754 rs2
feature: T69 ATF2 s990 sa754 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RAC1_GDP-_GTP-RIGHT__RAC1_GTP-_GDP-_re76
controller: Galpha13

CaMKK
type: Protein
entity reference: CaMKK
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

MAPK7
type: Protein
entity reference: MAPK7
feature: T219 MAPK7 s1970 sa988 rs1
feature: ACTIVE 13
feature: Y221 MAPK7 s1970 sa988 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

uniprot P42338 40
type: UnificationXref
id: P42338
db: uniprot

Y238 CCK2R s1660 sa22 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y238
feature location: Y238 CCK2R s1660 sa22 rs7 Y238
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789
comment: MODIFICATION_RESIDUE_NAME=Y238

HETERODIMER_ASSOCIATION_LEFT__CCK2R-_G17-RIGHT__CCK2R-_re663
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re663 628
participant stoichiometry: PARTICIPANT STOICHIOMETRY re663 627
participant stoichiometry: PARTICIPANT STOICHIOMETRY re663 626
left: G17
left: CCK2R
interaction type: HETERODIMER_ASSOCIATION
right: CCK2R

T268 9 RAF1 s156 sa686 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T268 9
feature location: T268 9 RAF1 s156 sa686 rs7 T268 9
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T268/9
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE TRANSITION LEFT Guanylate cyclase-RIGHT Guanylate cyclase- re353
control type: ACTIVATION
controller: NO

PARTICIPANT STOICHIOMETRY re441 1172
type: Stoichiometry
physical entity: HuR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re441 1173
type: Stoichiometry
physical entity: HuR
stoichiometric coefficient: 1.0

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__CCND1-RIGHT__CCND1-_re421
control type: INHIBITION
controller: ICER

Adhesion
type: Pathway

s21
type: PhysicalEntity
cellular location: Late endosome
comment: SPECIES_TYPE=DEGRADED

PARTICIPANT STOICHIOMETRY re620 796
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 2.0

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__IL8-RIGHT__IL8-_re426
controller: NFKB1/RELA heterodimer

PARTICIPANT STOICHIOMETRY re620 795
type: Stoichiometry
physical entity: MAPK1/3
stoichiometric coefficient: 2.0

S70 FOS s1040 sa339 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S70
feature location: S70 FOS s1040 sa339 rs4 S70
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S70
comment: MODIFICATION_RESIDUE_ANGLE=5.5330859376426975

TRANSCRIPTION_LEFT__JUN-RIGHT__JUN-_re209
type: TemplateReaction
product: JUN
xref: TRANSCRIPTION
participant: JUN
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

TRANSCRIPTION_LEFT__NR4A1-RIGHT__NR4A1-_re445
type: TemplateReaction
product: NR4A1
xref: TRANSCRIPTION
participant: NR4A1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

SRC
type: Protein
entity reference: SRC PROTEIN
feature: ACTIVE 13
feature: Y527 SRC s107 sa677 rs2
feature: Y416 SRC s107 sa677 rs1
feature: SRC s107 sa677 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S315 FOXO3 s1625 sa902 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S315
feature location: S315 FOXO3 s1625 sa902 rs1 S315
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S315
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.71

Y527 p54 SRC s879 sa96 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 p54 SRC s879 sa96 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y527
comment: MODIFICATION_RESIDUE_ANGLE=5.515574907064658

VMAT2
type: RnaRegion
entity reference: VMAT2
cellular location: CELL
comment: SPECIES_TYPE=RNA

uniprot Q16539 80
type: UnificationXref
id: Q16539
db: uniprot

PARTICIPANT STOICHIOMETRY re111 1101
type: Stoichiometry
physical entity: AKT1-PIP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re111 1102
type: Stoichiometry
physical entity: AKT1-PIP3
stoichiometric coefficient: 1.0

T202 MAPK1 3 s1788 sa954 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T202
feature location: T202 MAPK1 3 s1788 sa954 rs3 T202
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T202
comment: MODIFICATION_RESIDUE_ANGLE=0.8054181165820891

SRF s1061 sa747 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SRF
stoichiometric coefficient: 2.0

STATE_TRANSITION_LEFT__p70S6K1-RIGHT__p70S6K1-_re123
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re123 1062
participant stoichiometry: PARTICIPANT STOICHIOMETRY re123 1061
left: p70S6K1
interaction type: STATE_TRANSITION
right: p70S6K1

TRUNCATION_LEFT__active_CCK2R_Beta_arrestin_complex-RIGHT__G17-_CCK2R-_re336
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re336 547
participant stoichiometry: PARTICIPANT STOICHIOMETRY re336 546
participant stoichiometry: PARTICIPANT STOICHIOMETRY re336 548
left: active CCK2R/Beta-arrestin complex
interaction type: TRUNCATION
right: CCK2R
right: G17

GTP-binding protein Rheb
type: ProteinReference
xref: uniprot Q15382 64
xref: PTHR24070:SF264
organism: Homo sapiens

S721 RPTOR s954 sa309 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S721
feature location: S721 RPTOR s954 sa309 rs2 S721
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S721
comment: MODIFICATION_RESIDUE_ANGLE=5.5847024334941295

Y94 CCK s1750 sa789 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 CCK s1750 sa789 rs3 Y94
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.474173865666921
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y94

p60 SRC s963 sa286 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p60 SRC
stoichiometric coefficient: 1.0

GDP s687 sa251 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re166 917
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

FAK1
type: ProteinReference
xref: P07129
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.FAK1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=PMID: 15246681
member entity reference: Focal adhesion kinase 1

PARTICIPANT STOICHIOMETRY re166 916
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

Nitric oxide synthase, brain
type: ProteinReference
xref: uniprot P29475 134
xref: PTHR19384:SF63
organism: Homo sapiens

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

SRF
type: ProteinReference
xref: P07181
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.SRF
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Serum response factor

T69 ATF2 s1012 sa753 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T69
feature location: T69 ATF2 s1012 sa753 rs1 T69
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.78
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T69

DISSOCIATION_LEFT__4E_BP1_EIF4E_complex-RIGHT__4E_BP1-_EIF4E-_re118
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re118 1087
participant stoichiometry: PARTICIPANT STOICHIOMETRY re118 1088
participant stoichiometry: PARTICIPANT STOICHIOMETRY re118 1086
left: 4E-BP1/EIF4E complex
interaction type: DISSOCIATION
right: EIF4E
right: 4E-BP1

BCL2L1
type: Protein
entity reference: BCL2L1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1773 sa896 224
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

E-cadherin
type: DnaRegion
entity reference: E-cadherin
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

S260 CCK1R s1485 sa456 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S260
feature location: S260 CCK1R s1485 sa456 rs1 S260
comment: MODIFICATION_RESIDUE_NAME=S260
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8807084252156057

PARTICIPANT STOICHIOMETRY re581 815
type: Stoichiometry
physical entity: FOXO1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re581 816
type: Stoichiometry
physical entity: FOXO1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re113 1098
type: Stoichiometry
physical entity: RHEB-GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re113 1097
type: Stoichiometry
physical entity: RHEB-GDP
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__PAI2-RIGHT__PAI2-_re229
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re229 794
participant stoichiometry: PARTICIPANT STOICHIOMETRY re229 793
left: PAI2
interaction type: TRANSPORT
right: PAI2

T491 RAF1 s1336 sa692 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T491
feature location: T491 RAF1 s1336 sa692 rs4 T491
comment: MODIFICATION_RESIDUE_NAME=T491
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.3986264000533355

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Migration
controller: STAT3

IRS1
type: ProteinReference
xref: P07106
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.IRS1
member entity reference: P35568

PARTICIPANT STOICHIOMETRY re631 747
type: Stoichiometry
physical entity: MEF2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re631 748
type: Stoichiometry
physical entity: MEF2
stoichiometric coefficient: 1.0

uniprot Q969H4 33
type: UnificationXref
id: Q969H4
db: uniprot

uPA
type: RnaRegion
entity reference: uPA
cellular location: CELL
comment: SPECIES_TYPE=RNA

PTHR23351:SF4
type: RelationshipXref
id: PTHR23351:SF4
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re144 983
type: Stoichiometry
physical entity: RSK1/2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re144 984
type: Stoichiometry
physical entity: RSK1/2
stoichiometric coefficient: 1.0

PTHR24356:SF163
type: RelationshipXref
id: PTHR24356:SF163
db: PANTHER Family
relationship type: By Homology

uniprot P22694 109
type: UnificationXref
id: P22694
db: uniprot

SRF
type: Protein
entity reference: SRF
feature: S103 SRF s1060 sa746 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLCbeta-RIGHT__PLCbeta-_re377
controller: Galpha q complex

Y845 EGFR s727 sa266 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y845
feature location: Y845 EGFR s727 sa266 rs3 Y845
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=3.273137173567691
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y845

PARTICIPANT STOICHIOMETRY re58 709
type: Stoichiometry
physical entity: SHC1
stoichiometric coefficient: 1.0

S2448 mTOR s924 sa308 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S2448
feature location: S2448 mTOR s924 sa308 rs3 S2448
comment: MODIFICATION_RESIDUE_ANGLE=3.8000982565743886
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S2448

Ca2 PLUS s2005 sa1003 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot Q05397 73
type: UnificationXref
id: Q05397
db: uniprot

Y390 CCK2R s1410 sa568 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y390
feature location: Y390 CCK2R s1410 sa568 rs1 Y390
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4010743852436276
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y390

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HRAS_GDP-_GTP-RIGHT__HRAS_GTP-_GDP-_re156
controller: IRS-1-GRB2-SOS1

PARTICIPANT STOICHIOMETRY re7 488
type: Stoichiometry
physical entity: PKCalpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re373 1224
type: Stoichiometry
physical entity: beta-catenin/TCF-4
stoichiometric coefficient: 1.0

T559 MAP3K14 s863 sa60 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T559
feature location: T559 MAP3K14 s863 sa60 rs1 T559
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T559
comment: MODIFICATION_RESIDUE_ANGLE=0.8027231228841566

T268 9 RAF1 s731 sa687 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T268 9
feature location: T268 9 RAF1 s731 sa687 rs7 T268 9
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T268/9
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__RHEB_GTP-RIGHT__RHEB_GDP-_re114
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re114 1095
participant stoichiometry: PARTICIPANT STOICHIOMETRY re114 1096
left: RHEB-GTP
interaction type: STATE_TRANSITION
right: RHEB-GDP

STATE_TRANSITION_LEFT__MAP2K4-RIGHT__MAP2K4-_re150
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re150 952
participant stoichiometry: PARTICIPANT STOICHIOMETRY re150 951
left: MAP2K4
interaction type: STATE_TRANSITION
right: MAP2K4 s995 sa219

STATE_TRANSITION_LEFT__PLCgamma1-RIGHT__PLCgamma1-_re583
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re583 808
participant stoichiometry: PARTICIPANT STOICHIOMETRY re583 807
left: PLCgamma1
interaction type: STATE_TRANSITION
right: PLCgamma1 s716 sa18

PARTICIPANT STOICHIOMETRY re153 946
type: Stoichiometry
physical entity: MAPK1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re153 945
type: Stoichiometry
physical entity: MAPK1 s987 sa202
stoichiometric coefficient: 1.0

Ca2+
type: SmallMolecule
cellular location: Endoplasmic Reticulum
comment: SPECIES_TYPE=ION

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s736 sa493 396
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q06413 160
type: UnificationXref
id: Q06413
db: uniprot

STATE_TRANSITION_LEFT__SP3-RIGHT__SP3-_re196
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re196 776
participant stoichiometry: PARTICIPANT STOICHIOMETRY re196 775
left: SP3
interaction type: STATE_TRANSITION
right: SP3

K721 EGFR s727 sa266 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY K721
feature location: K721 EGFR s727 sa266 rs2 K721
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.613037263076192
comment: MODIFICATION_RESIDUE_NAME=K721

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MMP3-RIGHT__MMP3-_re51
controller: PKC

PARTICIPANT STOICHIOMETRY re58 710
type: Stoichiometry
physical entity: p52 SHC1
stoichiometric coefficient: 1.0

S876 PRKD2 s773 sa696 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S876
feature location: S876 PRKD2 s773 sa696 rs1 S876
comment: MODIFICATION_RESIDUE_ANGLE=5.583002134385839
comment: MODIFICATION_RESIDUE_NAME=S876
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

Y77 Pro CCK @ TGN s1191 sa499 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 Pro CCK @ TGN s1191 sa499 rs1 Y77
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.423514332769269
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y77

Y341 RAF1 s154 sa685 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y341
feature location: Y341 RAF1 s154 sa685 rs2 Y341
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y341
comment: MODIFICATION_RESIDUE_ANGLE=0.813361255902311

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__A_Raf-RIGHT__A_Raf-_re378
controller: HRAS-GTP

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__cGK_1-RIGHT__cGK_1-_re359
controller: Guanylate cyclase s1903 sa624

PARTICIPANT STOICHIOMETRY re7 489
type: Stoichiometry
physical entity: PKCalpha
stoichiometric coefficient: 1.0

S78 HSP27 s1586 sa873 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S78
feature location: S78 HSP27 s1586 sa873 rs2 S78
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S78
comment: MODIFICATION_RESIDUE_ANGLE=2.3742496203853896

KNOWN_TRANSITION_OMITTED_LEFT__Novel_PKC-RIGHT__PKC-_re23
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 860
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 861
left: Novel PKC
interaction type: KNOWN_TRANSITION_OMITTED
right: PKC

NFKB RELA heterodimer s1941 csa83 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NFKB/RELA heterodimer
stoichiometric coefficient: 1.0

RHEB-GDP
type: Protein
entity reference: RHEB-GDP
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Guanylate cyclase
type: ProteinReference
xref: P07116
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.Guanylate_br_cyclase
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Retinal guanylyl cyclase 1

LYN
type: Protein
entity reference: LYN
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

GTP
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TRANSLATION_LEFT__ODC1-RIGHT__ODC1-_re486
type: TemplateReaction
product: ODC1
xref: TRANSLATION
participant: ODC1
participant: ODC1 s1456 sa786
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PDK1-PIP3
type: Complex
component stoichiometry: PDPK1 s902 sa306 STOICHIOMETRY ID COMPLEX
component stoichiometry: PI3,4,5 P3 s903 sa307 STOICHIOMETRY ID COMPLEX
component: PDPK1
component: PI3,4,5-P3
feature: COMPLEX BINDING FEATURE s1937 csa24 273
feature: COMPLEX BINDING FEATURE s1937 csa24 271
cellular location: CELL

BAD
type: Protein
entity reference: BAD
feature: S112 BAD s790 sa150 rs1
feature: S136 BAD s790 sa150 rs2
feature: ACTIVE 13
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

PLCbeta s1692 sa11 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q08828 57
type: UnificationXref
id: Q08828
db: uniprot

STATE_TRANSITION_LEFT__Pro_CCK_@_TGN-RIGHT__Pro_CCK_@_secretory_granule-_re303
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re303 632
participant stoichiometry: PARTICIPANT STOICHIOMETRY re303 631
left: Pro CCK @ TGN
interaction type: STATE_TRANSITION
right: Pro-CCK @ secretory granule

STATE_TRANSITION_LEFT__NADP-RIGHT__NAADP-_re350
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re350 540
participant stoichiometry: PARTICIPANT STOICHIOMETRY re350 539
left: NADP
interaction type: STATE_TRANSITION
right: NAADP

INHIBITION
type: Control
xref: INHIBITION
control type: INHIBITION
controller: IEX1

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__uPA-RIGHT__uPA-_re605
controller: p38MAPK s998 sa227

Novel PKC
type: Protein
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR10201:SF143
type: RelationshipXref
id: PTHR10201:SF143
db: PANTHER Family
relationship type: By Homology

uniprot P10909 133
type: UnificationXref
id: P10909
db: uniprot

Y576 FAK1 s668 sa118 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y576
feature location: Y576 FAK1 s668 sa118 rs3 Y576
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=1.55
comment: MODIFICATION_RESIDUE_NAME=Y576

T202 MAPK1 3 s1857 sa216 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T202
feature location: T202 MAPK1 3 s1857 sa216 rs3 T202
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T202
comment: MODIFICATION_RESIDUE_ANGLE=0.8054181165820891

CCND1
type: DnaRegion
entity reference: CCND1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

T261 MAP2K4 s996 sa220 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T261
feature location: T261 MAP2K4 s996 sa220 rs2 T261
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T261
comment: MODIFICATION_RESIDUE_ANGLE=5.61

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RSK1_2-RIGHT__RSK1_2-_re148
controller: RSK1 2 s539 sa214

Y317 p52 SHC1 s899 sa274 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y317
feature location: Y317 p52 SHC1 s899 sa274 rs1 Y317
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y317
comment: MODIFICATION_RESIDUE_ANGLE=0.8063981142904283

Pro HBEGF
type: Protein
entity reference: Pro HBEGF
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR22968:SF12
type: RelationshipXref
id: PTHR22968:SF12
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re634 741
type: Stoichiometry
physical entity: BAX/MCL1 heterodimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re634 740
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 2.0

uniprot Q05940 102
type: UnificationXref
id: Q05940
db: uniprot

PARTICIPANT STOICHIOMETRY re406 501
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

RAF1 s1336 sa692 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re406 502
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

MOB1
type: RnaRegion
entity reference: MOB1
cellular location: CELL
comment: SPECIES_TYPE=RNA

Y94 Pre pro CCK @ ER s1189 sa497 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 Pre pro CCK @ ER s1189 sa497 rs3 Y94
comment: MODIFICATION_RESIDUE_ANGLE=5.529646328540765
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y94

Y Progastrin @Golgi s1403 sa772 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y Progastrin @Golgi s1403 sa772 rs1 Y
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.77

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__G34_Gly-RIGHT__G17___Gly-_re47
controller: Prohormone convertase

PARTICIPANT STOICHIOMETRY re634 739
type: Stoichiometry
physical entity: MCL1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re80 608
type: Stoichiometry
physical entity: ROCK1 s788 sa137
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re80 609
type: Stoichiometry
physical entity: ROCK1
stoichiometric coefficient: 1.0

Y407 FAK1 s776 sa285 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y407
feature location: Y407 FAK1 s776 sa285 rs2 Y407
comment: MODIFICATION_RESIDUE_NAME=Y407
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.74

GDP s136 sa578 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

FOXO3
type: Protein
entity reference: FOXO3
feature: S315 FOXO3 s1991 sa995 rs1
feature: T32 FOXO3 s1991 sa995 rs3
feature: S253 FOXO3 s1991 sa995 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y341 RAF1 s742 sa680 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y341
feature location: Y341 RAF1 s742 sa680 rs2 Y341
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y341
comment: MODIFICATION_RESIDUE_ANGLE=0.813361255902311

uniprot Q14289 72
type: UnificationXref
id: Q14289
db: uniprot

GRB2 @EGFR
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s887 sa277 264
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Eukaryotic translation initiation factor 4E-binding protein 1
type: ProteinReference
xref: PTHR12669:SF14
xref: uniprot Q13541 93
organism: Homo sapiens

p110
type: Protein
entity reference: p110
feature: COMPLEX PARTICIPANT BINDING FEATURE s886 sa299 204
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re278 599
type: Stoichiometry
physical entity: ICER
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__E_cadherin-RIGHT__E_cadherin-_re367
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re367 507
participant stoichiometry: PARTICIPANT STOICHIOMETRY re367 508
left: E-cadherin
interaction type: KNOWN_TRANSITION_OMITTED
right: E-cadherin

S505 PLA2 s1516 sa827 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S505
feature location: S505 PLA2 s1516 sa827 rs2 S505
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S505

TCF7L2
type: Protein
entity reference: TCF7L2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1875 sa342 452
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

Ca2+
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=ION

TRANSPORT_LEFT__STAT3-RIGHT__STAT3-_re533
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re533 1006
participant stoichiometry: PARTICIPANT STOICHIOMETRY re533 1005
left: STAT3
interaction type: TRANSPORT
right: STAT3

PARTICIPANT STOICHIOMETRY re310 603
type: Stoichiometry
physical entity: FAK2-SRC complex
stoichiometric coefficient: 1.0

BAD s1565 sa857 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

S2448 mTOR s644 sa311 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S2448
feature location: S2448 mTOR s644 sa311 rs3 S2448
comment: MODIFICATION_RESIDUE_ANGLE=3.8000982565743886
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S2448

PARTICIPANT STOICHIOMETRY re310 602
type: Stoichiometry
physical entity: FAK2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re310 601
type: Stoichiometry
physical entity: SRC @Galphaq
stoichiometric coefficient: 1.0

Y576 FAK1 s669 sa111 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y576
feature location: Y576 FAK1 s669 sa111 rs3 Y576
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=1.55
comment: MODIFICATION_RESIDUE_NAME=Y576

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__MOB1-RIGHT__MOB1-_re501
controller: NFKB1/RELA heterodimer

STATE_TRANSITION_LEFT__CCK-RIGHT__CCK_8-_re500
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re500 1119
participant stoichiometry: PARTICIPANT STOICHIOMETRY re500 1118
left: CCK
interaction type: STATE_TRANSITION
right: CCK-8

CDC42-GTP
type: ProteinReference
xref: P07155
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CDC42-GTP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cell division control protein 42 homolog

T246 PRAS40 s648 sa176 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T246
feature location: T246 PRAS40 s648 sa176 rs2 T246
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T246
comment: MODIFICATION_RESIDUE_ANGLE=5.5644565530974495

PARTICIPANT STOICHIOMETRY re383 1194
type: Stoichiometry
physical entity: A-Raf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re383 1193
type: Stoichiometry
physical entity: RAF
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__BAX-_BCL2-RIGHT__BAX_BCL2_heterodimer-_re560
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re560 907
participant stoichiometry: PARTICIPANT STOICHIOMETRY re560 909
participant stoichiometry: PARTICIPANT STOICHIOMETRY re560 908
left: BAX
left: BCL2
interaction type: HETERODIMER_ASSOCIATION
right: BAX/BCL2 heterodimer

STATE_TRANSITION_LEFT__ELK1-RIGHT__ELK1-_re189
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re189 819
participant stoichiometry: PARTICIPANT STOICHIOMETRY re189 820
left: ELK1
interaction type: STATE_TRANSITION
right: ELK1

BAD s1561 sa290 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BAD
stoichiometric coefficient: 1.0

NFKB1-RelA-IKB complex
type: Complex
component stoichiometry: IKBalpha s1210 sa255 STOICHIOMETRY ID COMPLEX
component stoichiometry: NFKB RELA heterodimer s1941 csa83 STOICHIOMETRY ID COMPLEX
component: IKBalpha
component: NFKB/RELA heterodimer
feature: COMPLEX BINDING FEATURE s1943 csa3 309
feature: COMPLEX BINDING FEATURE s1943 csa3 307
cellular location: CELL

T268 9 RAF1 s742 sa680 rs7
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T268 9
feature location: T268 9 RAF1 s742 sa680 rs7 T268 9
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T268/9
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re381 1195
type: Stoichiometry
physical entity: PKCtheta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re381 1196
type: Stoichiometry
physical entity: PKCtheta
stoichiometric coefficient: 1.0

AP-2 complex subunit mu
type: ProteinReference
xref: uniprot Q96CW1 104
xref: PTHR10529:SF236
organism: Homo sapiens

PTHR23235:SF3
type: RelationshipXref
id: PTHR23235:SF3
db: PANTHER Family
relationship type: By Homology

S112 BAD s1561 sa290 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S112
feature location: S112 BAD s1561 sa290 rs1 S112
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.538835828280262
comment: MODIFICATION_RESIDUE_NAME=S112

Y407 FAK1 s1450 sa782 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y407
feature location: Y407 FAK1 s1450 sa782 rs2 Y407
comment: MODIFICATION_RESIDUE_NAME=Y407
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.74

S82 CCK2R s1688 sa565 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S82
feature location: S82 CCK2R s1688 sa565 rs2 S82
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.827433388230814
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S82

PARTICIPANT STOICHIOMETRY re528 1037
type: Stoichiometry
physical entity: IRS-1-GRB2-SOS1
stoichiometric coefficient: 1.0

p60 SRC s1451 sa783 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p60 SRC
stoichiometric coefficient: 1.0

PTHR11849:SF21
type: RelationshipXref
id: PTHR11849:SF21
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re528 1035
type: Stoichiometry
physical entity: Complex (GRB2/SOS1)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re528 1036
type: Stoichiometry
physical entity: IRS1
stoichiometric coefficient: 1.0

S380 RSK1 2 s536 sa209 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S380
feature location: S380 RSK1 2 s536 sa209 rs4 S380
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=1.8133457596088143
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S380

Y418 SRC @Galphaq s1894 sa976 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y418
feature location: Y418 SRC @Galphaq s1894 sa976 rs3 Y418
comment: MODIFICATION_RESIDUE_NAME=Y418
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3192345766207003

BCL2L1
type: Protein
entity reference: BCL2L1
feature: ACTIVE 13
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

PTHR11347:SF34
type: RelationshipXref
id: PTHR11347:SF34
db: PANTHER Family
relationship type: By Homology

uniprot P41220 85
type: UnificationXref
id: P41220
db: uniprot

T443 CCK2R s1410 sa568 rs11
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T443
feature location: T443 CCK2R s1410 sa568 rs11 T443
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T443
comment: MODIFICATION_RESIDUE_ANGLE=0.25278736068041796

Ggamma s21 sa250 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Inflammatory response
controller: COX2

PARTICIPANT STOICHIOMETRY re373 1222
type: Stoichiometry
physical entity: beta-catenin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re373 1223
type: Stoichiometry
physical entity: TCF7L2
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p66_SHC1-RIGHT__p66_SHC1-_re61
controller: SRC @Galphaq

PRKD2
type: ProteinReference
xref: P07216
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PRKD2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Serine/threonine-protein kinase D2

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re499 1009
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re499 1010
type: Stoichiometry
physical entity: CCK-22
stoichiometric coefficient: 1.0

Nuclear factor of activated T-cells, cytoplasmic 2
type: ProteinReference
xref: uniprot Q13469 162
xref: PTHR12533:SF4
organism: Homo sapiens

Rho-associated protein kinase 1
type: ProteinReference
xref: PTHR22988:SF33
xref: uniprot Q13464 169
organism: Homo sapiens

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re4
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 491
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 490
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

Conventional PKC
type: Protein
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y IRS1 s1667 sa819 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y IRS1 s1667 sa819 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.7039197825007742

RELA p65 s1881 sa972 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RELA (p65)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re512 1081
type: Stoichiometry
physical entity: TACR1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re512 1080
type: Stoichiometry
physical entity: TACR1
stoichiometric coefficient: 1.0

RPTOR
type: Protein
feature: S722 RPTOR s954 sa309 rs3
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s954 sa309 184
feature: S721 RPTOR s954 sa309 rs2
feature: S719 RPTOR s954 sa309 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE TRANSITION LEFT ROCK1-RIGHT ROCK1- re80
controller: RHOA-GTP

Transcription factor AP-1
type: DnaReference
xref: PTHR11462:SF8
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NOS1-RIGHT__NOS1-_re355
controller: SHP-2

p85
type: Protein
entity reference: p85
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p46_SHC1-RIGHT__p46_SHC1-_re60
controller: PKCepsilon

S36 IKBalpha s844 sa252 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S36
feature location: S36 IKBalpha s844 sa252 rs2 S36
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.54004418782393
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S36

S SOS1 s744 sa110 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S
feature location: S SOS1 s744 sa110 rs2 S
comment: MODIFICATION_RESIDUE_NAME=S
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.511144255404544

Conventional PKC
type: Protein
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S749 RSK1 2 s536 sa209 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S749
feature location: S749 RSK1 2 s536 sa209 rs6 S749
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=S749
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.408013221559381

PARTICIPANT STOICHIOMETRY re548 956
type: Stoichiometry
physical entity: cAMP s1840 sa472
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__RAC1_GDP-_GTP-RIGHT__RAC1_GTP-_GDP-_re76
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re76 651
participant stoichiometry: PARTICIPANT STOICHIOMETRY re76 650
participant stoichiometry: PARTICIPANT STOICHIOMETRY re76 649
participant stoichiometry: PARTICIPANT STOICHIOMETRY re76 652
left: RAC1-GDP
left: GTP
interaction type: STATE_TRANSITION
right: GDP
right: RAC1-GTP

Y416 SRC @Galphaq s718 sa94 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 SRC @Galphaq s718 sa94 rs1 Y416
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=0.7928900377700789

PARTICIPANT STOICHIOMETRY re548 955
type: Stoichiometry
physical entity: PKA Holoenzyme II
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re548 958
type: Stoichiometry
physical entity: PKA-R2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re548 957
type: Stoichiometry
physical entity: PKA-Calpha/beta/gamma
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__cAMP-RIGHT__s785-_re299
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re299 556
participant stoichiometry: PARTICIPANT STOICHIOMETRY re299 555
left: cAMP s1840 sa472
interaction type: STATE_TRANSITION
right: s785

IEX1
type: RnaRegion
entity reference: IEX1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

uniprot Q02447 116
type: UnificationXref
id: Q02447
db: uniprot

TRANSPORT_LEFT__MMP9-RIGHT__MMP9-_re423
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re423 1189
participant stoichiometry: PARTICIPANT STOICHIOMETRY re423 1188
left: MMP9
interaction type: TRANSPORT
right: MMP9

S32 IKBalpha s852 sa62 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S32
feature location: S32 IKBalpha s852 sa62 rs1 S32
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S32
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Gastric mucosa differentiation
controller: TFF1

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

PI3,4,5-P3
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s903 sa307 274
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

AP2M1
type: ProteinReference
xref: P07067
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.AP2M1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: AP-2 complex subunit mu

Y204 MAPK1 3 s828 sa326 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y204
feature location: Y204 MAPK1 3 s828 sa326 rs4 Y204
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.500664060131579
comment: MODIFICATION_RESIDUE_NAME=Y204

p70S6K1
type: Protein
entity reference: p70S6K1
feature: ACTIVE 13
feature: T389 p70S6K1 s650 sa171 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re196 776
type: Stoichiometry
physical entity: SP3
stoichiometric coefficient: 1.0

S212 PRAS40 s647 sa173 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S212
feature location: S212 PRAS40 s647 sa173 rs3 S212
comment: MODIFICATION_RESIDUE_ANGLE=2.3412474663214593
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S212

S73 JUN s1050 sa349 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S73
feature location: S73 JUN s1050 sa349 rs2 S73
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.53026601520083
comment: MODIFICATION_RESIDUE_NAME=S73

Cadherin-1
type: ProteinReference
xref: uniprot P12830 86
xref: PTHR24027:SF319
organism: Homo sapiens

TRANSCRIPTION_LEFT__CXCL1-RIGHT__CXCL1-_re449
type: TemplateReaction
product: CXCL1
xref: TRANSCRIPTION
participant: CXCL1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

TRANSCRIPTION_LEFT__PAI1-RIGHT__PAI1-_re603
type: TemplateReaction
product: PAI1
xref: TRANSCRIPTION
participant: PAI1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re69 674
type: Stoichiometry
physical entity: FAK1
stoichiometric coefficient: 1.0

E-cadherin
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.E-cadherin
comment: ENTITY_REFERENCE_NOTES=

STATE_TRANSITION_LEFT__CCK-RIGHT__s855-_re284
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re284 580
participant stoichiometry: PARTICIPANT STOICHIOMETRY re284 579
left: CCK s1780 sa949
interaction type: STATE_TRANSITION
right: s855

PARTICIPANT STOICHIOMETRY re69 673
type: Stoichiometry
physical entity: FAK1
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED_LEFT__Novel_PKC-RIGHT__PKCtheta-_re628
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re628 784
participant stoichiometry: PARTICIPANT STOICHIOMETRY re628 783
left: Novel PKC
interaction type: KNOWN_TRANSITION_OMITTED
right: PKCtheta

PARTICIPANT STOICHIOMETRY re196 775
type: Stoichiometry
physical entity: SP3
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ACAT1-RIGHT__ACAT1-_re452
controller: MAPK1/3

PARTICIPANT STOICHIOMETRY re337 541
type: Stoichiometry
physical entity: Galpha13beta/gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re337 543
type: Stoichiometry
physical entity: Galpha13
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re337 542
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

RPS6
type: ProteinReference
xref: P07143
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RPS6
comment: ENTITY_REFERENCE_NOTES=
member entity reference: 40S ribosomal protein S6

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CaMKIV-RIGHT__CaMKIV-_re666
controller: Ca_CaM

STATE_TRANSITION_LEFT__SHP_2-RIGHT__SHP_2-_re358
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re358 522
participant stoichiometry: PARTICIPANT STOICHIOMETRY re358 523
left: SHP-2
interaction type: STATE_TRANSITION
right: SHP-2

TAC1
type: RnaRegion
entity reference: TAC1
cellular location: CELL
comment: SPECIES_TYPE=RNA

STATE_TRANSITION_LEFT__HDAC7-RIGHT__HDAC7-_re447
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re447 1163
participant stoichiometry: PARTICIPANT STOICHIOMETRY re447 1162
left: HDAC7
interaction type: STATE_TRANSITION
right: HDAC7

PARTICIPANT STOICHIOMETRY re100 1146
type: Stoichiometry
physical entity: IRS1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re100 1147
type: Stoichiometry
physical entity: IRS1
stoichiometric coefficient: 1.0

uniprot Q15418 120
type: UnificationXref
id: Q15418
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p46_SHC1-RIGHT__p46_SHC1-_re60
controller: PKCdelta

Y IRS1 s933 sa295 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y
feature location: Y IRS1 s933 sa295 rs1 Y
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y
comment: MODIFICATION_RESIDUE_ANGLE=0.7039197825007742

MAPK7
type: ProteinReference
xref: P07021
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.MAPK7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mitogen-activated protein kinase 7

PAI2
type: DnaRegion
entity reference: PAI2
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Y204 MAPK3 s830 sa203 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y204
feature location: Y204 MAPK3 s830 sa203 rs2 Y204
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.49
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y204

Y94 CCK s1910 sa946 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y94
feature location: Y94 CCK s1910 sa946 rs3 Y94
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.474173865666921
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y94

S73 JUN s192 sa338 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S73
feature location: S73 JUN s192 sa338 rs2 S73
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.53026601520083
comment: MODIFICATION_RESIDUE_NAME=S73

S181 HDAC7 s1389 sa738 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S181
feature location: S181 HDAC7 s1389 sa738 rs1 S181
comment: MODIFICATION_RESIDUE_NAME=S181
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7963402430732642

RPS6
type: Protein
entity reference: RPS6
feature: RPS6 s659 sa169 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MAPK1_3-RIGHT__MAPK1_3-_re143
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re143 985
participant stoichiometry: PARTICIPANT STOICHIOMETRY re143 986
left: MAPK1/3
interaction type: STATE_TRANSITION
right: MAPK1/3

GCG
type: DnaRegionReference
member entity reference: HGNC 4191
xref: G07291
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.GCG
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re529 1034
type: Stoichiometry
physical entity: NFKB1/RELA heterodimer
stoichiometric coefficient: 1.0

T491 RAF1 s742 sa680 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T491
feature location: T491 RAF1 s742 sa680 rs4 T491
comment: MODIFICATION_RESIDUE_NAME=T491
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.3986264000533355

PARTICIPANT STOICHIOMETRY re529 1033
type: Stoichiometry
physical entity: NFKB/RELA heterodimer
stoichiometric coefficient: 1.0

14 3 3 beta alpha s1334 sa690 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: 14-3-3 beta/alpha
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__beta_catenin-_TCF7L2-RIGHT__beta_catenin_TCF_4-_re373
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re373 1222
participant stoichiometry: PARTICIPANT STOICHIOMETRY re373 1224
participant stoichiometry: PARTICIPANT STOICHIOMETRY re373 1223
left: TCF7L2
left: beta-catenin
interaction type: HETERODIMER_ASSOCIATION
right: beta-catenin/TCF-4

PARTICIPANT STOICHIOMETRY re614 830
type: Stoichiometry
physical entity: NFKB1/RELA heterodimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re429 1185
type: Stoichiometry
physical entity: HuR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re614 831
type: Stoichiometry
physical entity: BIRC2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re429 1184
type: Stoichiometry
physical entity: HuR
stoichiometric coefficient: 1.0

S15 HSP27 s1585 sa872 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S15
feature location: S15 HSP27 s1585 sa872 rs1 S15
comment: MODIFICATION_RESIDUE_ANGLE=3.8870116001312134
comment: MODIFICATION_RESIDUE_NAME=S15
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

S621 RAF1 s1336 sa692 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S621
feature location: S621 RAF1 s1336 sa692 rs9 S621
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S621
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.46201537231871

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__PAI2-RIGHT__PAI2-_re225
controller: AP1 (FOS+JUN)

Galpha/sbeta/gamma
type: Complex
component stoichiometry: GDP s736 sa493 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta gamma s737 sa494 STOICHIOMETRY ID COMPLEX
component stoichiometry: GalphaS s1185 sa492 STOICHIOMETRY ID COMPLEX
component: GalphaS
component: Gbeta/gamma
component: GDP
feature: COMPLEX BINDING FEATURE s2021 csa47 397
feature: COMPLEX BINDING FEATURE s2021 csa47 395
feature: COMPLEX BINDING FEATURE s2021 csa47 393
cellular location: CELL

MAPKAP1
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s962 sa319 318
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CREB1
type: ProteinReference
xref: P07232
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.CREB1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: P16220

S876 PRKD2 s1388 sa736 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S876
feature location: S876 PRKD2 s1388 sa736 rs1 S876
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.583002134385839
comment: MODIFICATION_RESIDUE_NAME=S876
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

IRS-1-GRB2-SOS1
type: Complex
component stoichiometry: GRB2 s949 sa283 STOICHIOMETRY ID COMPLEX
component stoichiometry: IRS1 s911 sa282 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS1 s890 sa281 STOICHIOMETRY ID COMPLEX
component: SOS1
component: GRB2
component: IRS1
feature: COMPLEX BINDING FEATURE s1928 csa13 247
feature: COMPLEX BINDING FEATURE s1928 csa13 251
feature: COMPLEX BINDING FEATURE s1928 csa13 249
cellular location: CELL

S133 FOS s205 sa337 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S133
feature location: S133 FOS s205 sa337 rs5 S133
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S133
comment: MODIFICATION_RESIDUE_ANGLE=0.76

TAC1
type: RnaRegion
entity reference: TAC1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__CHGA-RIGHT__CHGA-_re232
controller: SP1

Myc proto-oncogene protein
type: DnaReference
xref: PTHR45851:SF1
organism: Homo sapiens

uniprot Q96B36 115
type: UnificationXref
id: Q96B36
db: uniprot

eco ECO:0000245 11
type: UnificationXref
id: ECO:0000245
db: eco

Calmodulin-1
type: ProteinReference
xref: uniprot P0DP23 158
organism: Homo sapiens

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__ITGB1-RIGHT__ITGB1-_re588
controller: PI3K Class I

PARTICIPANT STOICHIOMETRY re129 1051
type: Stoichiometry
physical entity: SNAI1
stoichiometric coefficient: 1.0

T573 RSK1 2 s538 sa212 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T573
feature location: T573 RSK1 2 s538 sa212 rs3 T573
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=T573

KNOWN_TRANSITION_OMITTED_LEFT__MEF2D-RIGHT__MEF2-_re201
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re201 906
participant stoichiometry: PARTICIPANT STOICHIOMETRY re201 905
left: MEF2D
interaction type: KNOWN_TRANSITION_OMITTED
right: MEF2

PARTICIPANT STOICHIOMETRY re129 1052
type: Stoichiometry
physical entity: SNAI1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re301 636
type: Stoichiometry
physical entity: Pre-pro CCK @ ER
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re301 635
type: Stoichiometry
physical entity: Signal-pre-pro CCK
stoichiometric coefficient: 1.0

Galpha q
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa24 382
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re61 699
type: Stoichiometry
physical entity: p66 SHC1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__BCL2-_BAD-RIGHT__BAD_BCL2_heterodimer-_re562
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re562 898
participant stoichiometry: PARTICIPANT STOICHIOMETRY re562 899
participant stoichiometry: PARTICIPANT STOICHIOMETRY re562 900
left: BAD
left: BCL2
interaction type: HETERODIMER_ASSOCIATION
right: BAD/BCL2 heterodimer

DISSOCIATION_LEFT__CCK_CCK1R-RIGHT__CCK1R-_CCK-_re285
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re285 576
participant stoichiometry: PARTICIPANT STOICHIOMETRY re285 574
participant stoichiometry: PARTICIPANT STOICHIOMETRY re285 575
left: CCK-CCK1R
interaction type: DISSOCIATION
right: CCK1R
right: CCK s1780 sa949

JAK2
type: ProteinReference
xref: P07156
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.JAK2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Tyrosine-protein kinase JAK2

Survival
type: Pathway

mTOR
type: Protein
feature: S1261 mTOR s958 sa316 rs1
feature: S2448 mTOR s958 sa316 rs3
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s958 sa316 312
feature: S2481 mTOR s958 sa316 rs2
feature: T2446 mTOR s958 sa316 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PLCbeta-RIGHT__PLCbeta-_re377
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re377 1215
participant stoichiometry: PARTICIPANT STOICHIOMETRY re377 1214
left: PLCbeta
interaction type: STATE_TRANSITION
right: PLCbeta

MOB1
type: DnaRegion
entity reference: MOB1
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Y881 FAK2 s1204 sa520 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y881
feature location: Y881 FAK2 s1204 sa520 rs4 Y881
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5
comment: MODIFICATION_RESIDUE_NAME=Y881

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1806 sa72 384
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

TAK1
type: Protein
entity reference: TAK1
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S244 PRKD2 s1820 sa695 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S244
feature location: S244 PRKD2 s1820 sa695 rs6 S244
comment: MODIFICATION_RESIDUE_NAME=S244
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.822805346332478

PTHR45640:SF7
type: RelationshipXref
id: PTHR45640:SF7
db: PANTHER Family
relationship type: By Homology

NFKB/RELA heterodimer
type: Complex
component stoichiometry: RELA p65 s1884 sa974 STOICHIOMETRY ID COMPLEX
component stoichiometry: NFKB1 p50 s1883 sa973 STOICHIOMETRY ID COMPLEX
component: RELA (p65)
component: NFKB1 (p50)
feature: COMPLEX PARTICIPANT BINDING FEATURE s1941 csa83 308
feature: COMPLEX BINDING FEATURE s1941 csa83 305
feature: COMPLEX BINDING FEATURE s1941 csa83 303
cellular location: CELL

S154 CCK2R s1660 sa22 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S154
feature location: S154 CCK2R s1660 sa22 rs3 S154
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.234636338452209
comment: MODIFICATION_RESIDUE_NAME=S154

PTHR18860:SF28
type: RelationshipXref
id: PTHR18860:SF28
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re105 1129
type: Stoichiometry
physical entity: PDPK1
stoichiometric coefficient: 1.0

RAF1 c11
type: CellularLocationVocabulary
comment: RAF1

PARTICIPANT STOICHIOMETRY re278 600
type: Stoichiometry
physical entity: ICER
stoichiometric coefficient: 1.0

NR4A1
type: RnaRegion
entity reference: NR4A1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

TAK1
type: Protein
entity reference: TAK1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

SRC @Galphaq
type: Protein
entity reference: SRC @Galphaq
feature: Y416 SRC @Galphaq s1769 sa881 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1769 sa881 282
feature: ACTIVE 13
feature: Y418 SRC @Galphaq s1769 sa881 rs3
feature: Y527 SRC @Galphaq s1769 sa881 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

HDAC7
type: Protein
entity reference: HDAC7
feature: S181 HDAC7 s1389 sa738 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

Rapamycin
type: PhysicalEntity
cellular location: CELL
comment: SPECIES_TYPE=DRUG

FAK2 s1892 sa975 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK2
stoichiometric coefficient: 1.0

Y31 Paxillin s672 sa119 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y31
feature location: Y31 Paxillin s672 sa119 rs1 Y31
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.79
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y31

Y1173 EGFR s727 sa266 rs12
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y1173
feature location: Y1173 EGFR s727 sa266 rs12 Y1173
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y1173
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.5722186619038552

PARTICIPANT STOICHIOMETRY re460 1144
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re460 1145
type: Stoichiometry
physical entity: ATF2
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__HRAS_GDP-RIGHT__HRAS_GTP-_re523
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re523 1047
participant stoichiometry: PARTICIPANT STOICHIOMETRY re523 1048
left: HRAS-GDP
interaction type: STATE_TRANSITION
right: HRAS-GTP

STATE_TRANSITION_LEFT__MAPK3-RIGHT__MAPK3-_re142
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re142 988
participant stoichiometry: PARTICIPANT STOICHIOMETRY re142 987
left: MAPK3
interaction type: STATE_TRANSITION
right: MAPK3

KNOWN_TRANSITION_OMITTED
type: Control
xref: KNOWN TRANSITION OMITTED
controlled: Gastric mucosa differentiation
controller: CHGA

S749 RSK1 2 s538 sa212 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S749
feature location: S749 RSK1 2 s538 sa212 rs6 S749
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=S749
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.408013221559381

CDC42-GDP
type: Protein
entity reference: CDC42-GDP
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

E-cadherin
type: ProteinReference
xref: P07171
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.E-cadherin
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cadherin-1

Y725 STAT3 s1785 sa325 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y725
feature location: Y725 STAT3 s1785 sa325 rs2 Y725
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.583002134385839
comment: MODIFICATION_RESIDUE_NAME=Y725
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

uniprot P22612 108
type: UnificationXref
id: P22612
db: uniprot

PARTICIPANT STOICHIOMETRY re359 520
type: Stoichiometry
physical entity: cGK 1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re359 521
type: Stoichiometry
physical entity: cGK 1
stoichiometric coefficient: 1.0

PPARgamma
type: Protein
entity reference: PPARgamma
feature: S84 PPARgamma s1446 sa779 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__VMAT2-RIGHT__VMAT2-_re233
controller: CREB1

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PAK1-RIGHT__PAK1-_re81
control type: ACTIVATION
controller: CDC42-GTP

PKCdelta
type: ProteinReference
xref: P07134
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PKC_delta_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein kinase C delta type

S136 BAD s791 sa149 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S136
feature location: S136 BAD s791 sa149 rs2 S136
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8079058030724882
comment: MODIFICATION_RESIDUE_NAME=S136

PARTICIPANT STOICHIOMETRY re286 573
type: Stoichiometry
physical entity: CCK1R (active)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re286 572
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re286 571
type: Stoichiometry
physical entity: CCK1R
stoichiometric coefficient: 1.0

S42 FOS s205 sa337 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S42
feature location: S42 FOS s205 sa337 rs3 S42
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S42
comment: MODIFICATION_RESIDUE_ANGLE=4.694422355731807

TRANSCRIPTION_LEFT__VMAT2-RIGHT__VMAT2-_re233
type: TemplateReaction
product: VMAT2
xref: TRANSCRIPTION
participant: VMAT2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PDPK1
type: Protein
entity reference: PDPK1
feature: S241 PDPK1 s76 sa164 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re599 750
type: Stoichiometry
physical entity: SAP1
stoichiometric coefficient: 1.0

uniprot P06307 24
type: UnificationXref
id: P06307
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SAP1-RIGHT__SAP1-_re599
controller: MAPK1/3

PARTICIPANT STOICHIOMETRY re172 874
type: Stoichiometry
physical entity: B-Raf
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re172 875
type: Stoichiometry
physical entity: B-Raf
stoichiometric coefficient: 1.0

PAK1
type: Protein
entity reference: PAK1
feature: T423 PAK1 s785 sa139 rs1
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

mLST8
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1767 sa310 186
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re599 749
type: Stoichiometry
physical entity: SAP1
stoichiometric coefficient: 1.0

ATP
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__CXCL2-RIGHT__CXCL2-_re505
controller: AP1 (FOS+JUN)

IP3R
type: Protein
entity reference: IP3R
feature: ACTIVE 13
feature: IP3R s1541 sa8 rs1
cellular location: Endoplasmic Reticulum
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re583 808
type: Stoichiometry
physical entity: PLCgamma1 s716 sa18
stoichiometric coefficient: 1.0

JAK2
type: Protein
entity reference: JAK2
feature: Y966 JAK2 s1633 sa153 rs2
feature: Y868 JAK2 s1633 sa153 rs1
feature: Y972 JAK2 s1633 sa153 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re583 807
type: Stoichiometry
physical entity: PLCgamma1
stoichiometric coefficient: 1.0

uniprot Q12778 59
type: UnificationXref
id: Q12778
db: uniprot

go GO:0005623 7
type: UnificationXref
id: GO:0005623
db: go

TRANSCRIPTION_LEFT__CCND1-RIGHT__CCND1-_re421
type: TemplateReaction
product: CCND1
xref: TRANSCRIPTION
participant: CCND1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

SOS1
type: Protein
entity reference: SOS1
feature: S SOS1 s749 sa276 rs2
feature: ACTIVE 13
feature: T SOS1 s749 sa276 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s749 sa276 262
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re337 545
type: Stoichiometry
physical entity: Gbeta/gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re337 544
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Y920 EGFR s727 sa266 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y920
feature location: Y920 EGFR s727 sa266 rs5 Y920
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y920
comment: MODIFICATION_RESIDUE_ANGLE=4.1797314024403995

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GMP-RIGHT__cGMP-_re352
controller: Guanylate cyclase s1903 sa624

S37 beta catenin s1852 sa183 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S37
feature location: S37 beta catenin s1852 sa183 rs1 S37
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S37

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CAS-RIGHT__CAS-_re71
controller: FAK1-SRC complex

PARTICIPANT STOICHIOMETRY re334 551
type: Stoichiometry
physical entity: CCK2R
stoichiometric coefficient: 1.0

Preprogastrin @ER
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re334 552
type: Stoichiometry
physical entity: CCK2R
stoichiometric coefficient: 1.0

uniprot P47712 111
type: UnificationXref
id: P47712
db: uniprot

uniprot P35354 145
type: UnificationXref
id: P35354
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK1-RIGHT__MAPK1-_re153
controller: MAP2K2

GAP
type: Protein
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CaMKIV
type: Protein
entity reference: CaMKIV
feature: CaMKIV s2009 sa1007 rs1
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__MMP7-RIGHT__MMP7-_re418
controller: beta-catenin

FOS
type: Protein
entity reference: FOS
feature: S133 FOS s205 sa337 rs5
feature: S42 FOS s205 sa337 rs3
feature: ACTIVE 13
feature: S21 FOS s205 sa337 rs1
feature: S70 FOS s205 sa337 rs4
feature: S374 FOS s205 sa337 rs6
feature: S32 FOS s205 sa337 rs2
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

CCK2R
type: Protein
entity reference: CCK2R
feature: Y390 CCK2R s1410 sa568 rs1
feature: S437 CCK2R s1410 sa568 rs4
feature: Y438 CCK2R s1410 sa568 rs5
feature: T443 CCK2R s1410 sa568 rs11
feature: T440 CCK2R s1410 sa568 rs8
feature: S442 CCK2R s1410 sa568 rs10
feature: S434 CCK2R s1410 sa568 rs12
feature: T439 CCK2R s1410 sa568 rs6
feature: ACTIVE 13
feature: S154 CCK2R s1410 sa568 rs3
feature: S82 CCK2R s1410 sa568 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1410 sa568 226
feature: Y238 CCK2R s1410 sa568 rs7
feature: I441 CCK2R s1410 sa568 rs9
cellular location: Endosome
comment: SPECIES_TYPE=PROTEIN

PTHR11945:SF23
type: RelationshipXref
id: PTHR11945:SF23
db: PANTHER Family
relationship type: By Homology

NF-kappa-B inhibitor alpha
type: ProteinReference
xref: uniprot P25963 172
xref: PTHR46680:SF1
organism: Homo sapiens

Y527 p60 SRC s1451 sa783 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 p60 SRC s1451 sa783 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y527
comment: MODIFICATION_RESIDUE_ANGLE=5.537766360638166

KNOWN_TRANSITION_OMITTED_LEFT___HBEGF-RIGHT___HBEGF-_re50
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re50 730
participant stoichiometry: PARTICIPANT STOICHIOMETRY re50 729
left: HBEGF
interaction type: KNOWN_TRANSITION_OMITTED
right: HBEGF

p110 s886 sa299 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: p110
stoichiometric coefficient: 1.0

GCG
type: DnaRegion
entity reference: GCG
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

HuR
type: Protein
entity reference: HuR
feature: S158 HuR s1075 sa730 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1075 sa730 190
feature: S221 HuR s1075 sa730 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y579 FAK2 s1591 sa878 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y579
feature location: Y579 FAK2 s1591 sa878 rs2 Y579
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y579
comment: MODIFICATION_RESIDUE_ANGLE=3.84

REG1A
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.REG1A

RSK1/2
type: Protein
entity reference: RSK1/2
feature: S380 RSK1 2 s536 sa209 rs4
feature: T573 RSK1 2 s536 sa209 rs3
feature: S221 RSK1 2 s536 sa209 rs5
feature: S363 RSK1 2 s536 sa209 rs1
feature: S749 RSK1 2 s536 sa209 rs6
feature: T359 RSK1 2 s536 sa209 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__PI3K_Class_I-RIGHT__PI3K_Class_I-_re102
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re102 1138
participant stoichiometry: PARTICIPANT STOICHIOMETRY re102 1137
left: PI3K Class I
interaction type: STATE_TRANSITION
right: PI3K Class I

TRANSPORT_LEFT__VMAT2-RIGHT__VMAT2-_re252
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re252 682
participant stoichiometry: PARTICIPANT STOICHIOMETRY re252 681
left: VMAT2
interaction type: TRANSPORT
right: VMAT2

ODC1
type: Protein
entity reference: ODC1
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36507 16
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re624 785
type: Stoichiometry
physical entity: uPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re624 786
type: Stoichiometry
physical entity: uPA
stoichiometric coefficient: 1.0

Y527 SRC s107 sa677 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y527
feature location: Y527 SRC s107 sa677 rs2 Y527
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.7913647605135847
comment: MODIFICATION_RESIDUE_NAME=Y527

S260 CCK1R s1672 sa775 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S260
feature location: S260 CCK1R s1672 sa775 rs1 S260
comment: MODIFICATION_RESIDUE_NAME=S260
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.8807084252156057

Y239 240 p46 SHC1 s947 sa279 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y239 240
feature location: Y239 240 p46 SHC1 s947 sa279 rs2 Y239 240
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y239/240
comment: MODIFICATION_RESIDUE_ANGLE=2.3695516018147504

PARTICIPANT STOICHIOMETRY re551 937
type: Stoichiometry
physical entity: PKA-Calpha/beta/gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re551 938
type: Stoichiometry
physical entity: PKA-Calpha/beta/gamma
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

S241 PDPK1 s1669 sa213 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S241
feature location: S241 PDPK1 s1669 sa213 rs1 S241
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=0.7668909901804244
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S241

PARTICIPANT STOICHIOMETRY re668 613
type: Stoichiometry
physical entity: NFAT1
stoichiometric coefficient: 1.0

uniprot Q8N5S9 56
type: UnificationXref
id: Q8N5S9
db: uniprot

PARTICIPANT STOICHIOMETRY re668 612
type: Stoichiometry
physical entity: NFAT1
stoichiometric coefficient: 1.0

IL8
type: RnaRegion
entity reference: IL8
feature: COMPLEX PARTICIPANT BINDING FEATURE s1079 sa732 408
cellular location: CELL
comment: SPECIES_TYPE=RNA

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__FOS-RIGHT__FOS-_re206
controller: ELK1

MEF2C
type: Protein
entity reference: MEF2C
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

uniprot P00749 170
type: UnificationXref
id: P00749
db: uniprot

TRANSPORT_LEFT__REG1A-RIGHT__REG1A-_re644
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re644 704
participant stoichiometry: PARTICIPANT STOICHIOMETRY re644 703
left: REG1A
interaction type: TRANSPORT
right: REG1A

PARTICIPANT STOICHIOMETRY re105 1130
type: Stoichiometry
physical entity: PDPK1
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__cAMP-_PKA_Holoenzyme_I-RIGHT__PKA_Calpha_beta_gamma-_PKA_R1-_re547
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re547 959
participant stoichiometry: PARTICIPANT STOICHIOMETRY re547 961
participant stoichiometry: PARTICIPANT STOICHIOMETRY re547 960
participant stoichiometry: PARTICIPANT STOICHIOMETRY re547 962
left: PKA Holoenzyme I
left: cAMP s1840 sa472
interaction type: DISSOCIATION
right: PKA-R1
right: PKA-Calpha/beta/gamma

PARTICIPANT STOICHIOMETRY re604 881
type: Stoichiometry
physical entity: PAI1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re604 880
type: Stoichiometry
physical entity: PAI1
stoichiometric coefficient: 1.0

S363 RSK1 2 s546 sa329 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S363
feature location: S363 RSK1 2 s546 sa329 rs1 S363
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=2.378634437717986
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S363

ITGB1
type: Protein
entity reference: ITGB1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot P62993 114
organism: Homo sapiens

GRB2
type: Protein
entity reference: GRB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s914 sa275 270
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

SRC @Galphaq
type: Protein
entity reference: SRC @Galphaq
feature: Y416 SRC @Galphaq s1894 sa976 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s1894 sa976 390
feature: ACTIVE 13
feature: Y527 SRC @Galphaq s1894 sa976 rs2
feature: Y418 SRC @Galphaq s1894 sa976 rs3
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y77 CCK s1910 sa946 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 CCK s1910 sa946 rs1 Y77
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3832305715485393
comment: MODIFICATION_RESIDUE_NAME=Y77

ITGAV
type: DnaRegionReference
member entity reference: Integrin alpha-V
xref: G07293
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.ITGAV
comment: ENTITY_REFERENCE_NOTES=

STATE_TRANSITION_LEFT__BAD_BCL2_heterodimer-RIGHT__BAD_BCL2_heterodimer-_re564
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re564 889
participant stoichiometry: PARTICIPANT STOICHIOMETRY re564 888
left: BAD/BCL2 heterodimer
interaction type: STATE_TRANSITION
right: BAD/BCL2 heterodimer

MCL1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.MCL1
comment: ENTITY_REFERENCE_NOTES=

CDC42-GTP
type: Protein
entity reference: CDC42-GTP
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 90STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 2.0

4E-BP1/EIF4E complex
type: Complex
component stoichiometry: EIF4E s733 sa314 STOICHIOMETRY ID COMPLEX
component stoichiometry: 4E BP1 s964 sa315 STOICHIOMETRY ID COMPLEX
component: EIF4E s733 sa314
component: 4E-BP1
feature: COMPLEX BINDING FEATURE s1975 csa27 425
feature: COMPLEX BINDING FEATURE s1975 csa27 427
cellular location: CELL

PKC
type: Protein
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

uniprot P45985 15
type: UnificationXref
id: P45985
db: uniprot

SOS1 s946 sa273 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ACAT1-RIGHT__ACAT1-_re452
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re452 1153
participant stoichiometry: PARTICIPANT STOICHIOMETRY re452 1152
left: ACAT1
interaction type: STATE_TRANSITION
right: ACAT1

Inflammatory response
type: Pathway

KNOWN_TRANSITION_OMITTED_LEFT__RAF-RIGHT__c_RAF___RAF1-_re176
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re176 863
participant stoichiometry: PARTICIPANT STOICHIOMETRY re176 862
left: RAF
interaction type: KNOWN_TRANSITION_OMITTED
right: c-RAF / RAF1

T202 MAPK1 3 s828 sa326 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T202
feature location: T202 MAPK1 3 s828 sa326 rs3 T202
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T202
comment: MODIFICATION_RESIDUE_ANGLE=0.8054181165820891

S33 beta catenin s932 sa321 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S33
feature location: S33 beta catenin s932 sa321 rs2 S33
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7304919088134321
comment: MODIFICATION_RESIDUE_NAME=S33

MEF2D
type: Protein
entity reference: MEF2D
feature: ACTIVE 13
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Pro_CCK_@_secretory_granule-RIGHT__CCK_GRR-_re304
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re304 630
participant stoichiometry: PARTICIPANT STOICHIOMETRY re304 629
left: Pro-CCK @ secretory granule
interaction type: STATE_TRANSITION
right: CCK-GRR

STATE_TRANSITION_LEFT__PKCepsilon-RIGHT__PKCepsilon-_re379
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re379 1206
participant stoichiometry: PARTICIPANT STOICHIOMETRY re379 1207
left: PKCepsilon
interaction type: STATE_TRANSITION
right: PKCepsilon

RAF1
type: Protein
entity reference: RAF1
feature: T491 RAF1 s1330 sa689 rs4
feature: S497 9 RAF1 s1330 sa689 rs8
feature: S621 RAF1 s1330 sa689 rs9
feature: S494 RAF1 s1330 sa689 rs5
feature: S43 RAF1 s1330 sa689 rs6
feature: S338 RAF1 s1330 sa689 rs1
feature: Y341 RAF1 s1330 sa689 rs2
feature: T268 9 RAF1 s1330 sa689 rs7
feature: S259 RAF1 s1330 sa689 rs3
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re23 860
type: Stoichiometry
physical entity: Novel PKC
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pro_CCK_@_secretory_granule-RIGHT__CCK_GRR-_re304
controller: Prohormone convertase

PTHR11461:SF49
type: RelationshipXref
id: PTHR11461:SF49
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re23 861
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GAS_REBP2-RIGHT__GAS_REBP2-_re597
controller: AP1 (FOS+JUN)

PTHR24082:SF488
type: RelationshipXref
id: PTHR24082:SF488
db: PANTHER Family
relationship type: By Homology

PTHR14166:SF16
type: RelationshipXref
id: PTHR14166:SF16
db: PANTHER Family
relationship type: By Homology

KLF4
type: Protein
entity reference: KLF4
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

cAMP-responsive element modulator
type: ProteinReference
xref: PTHR45879:SF4
xref: uniprot Q03060 106
organism: Homo sapiens

CK1
type: Protein
entity reference: CK1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

uniprot Q02846 34
type: UnificationXref
id: Q02846
db: uniprot

SHP-2
type: ProteinReference
xref: P07028
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.SHP-2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Tyrosine-protein phosphatase non-receptor type 11

AA
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

S363 RSK1 2 s1856 sa215 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S363
feature location: S363 RSK1 2 s1856 sa215 rs1 S363
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=2.378634437717986
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S363

FAK1 s776 sa285 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAK1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__AKT1-_PI3,4,5_P3-RIGHT__AKT1_PIP3-_re109
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re109 1115
participant stoichiometry: PARTICIPANT STOICHIOMETRY re109 1113
participant stoichiometry: PARTICIPANT STOICHIOMETRY re109 1114
left: PI3,4,5-P3
left: AKT1
interaction type: HETERODIMER_ASSOCIATION
right: AKT1-PIP3

TRANSPORT_LEFT__RSK1_2-RIGHT__RSK1_2-_re536
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re536 1000
participant stoichiometry: PARTICIPANT STOICHIOMETRY re536 999
left: RSK1/2
interaction type: TRANSPORT
right: RSK1/2

Gbeta/gamma
type: Protein
entity reference: Gbeta/gamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa576 192
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S430 CCK1R s1485 sa456 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S430
feature location: S430 CCK1R s1485 sa456 rs4 S430
comment: MODIFICATION_RESIDUE_ANGLE=5.556558434920722
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S430

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SHP_2-RIGHT__SHP_2-_re487
controller: CCK2R

PARTICIPANT STOICHIOMETRY re628 783
type: Stoichiometry
physical entity: Novel PKC
stoichiometric coefficient: 1.0

UNKNOWN_TRANSITION_LEFT__SHP_2-RIGHT__AKT1_PIP3-_re584
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re584 804
participant stoichiometry: PARTICIPANT STOICHIOMETRY re584 803
left: SHP-2
interaction type: UNKNOWN_TRANSITION
right: AKT1-PIP3

PARTICIPANT STOICHIOMETRY re628 784
type: Stoichiometry
physical entity: PKCtheta
stoichiometric coefficient: 1.0

PTHR11461:SF61
type: RelationshipXref
id: PTHR11461:SF61
db: PANTHER Family
relationship type: By Homology

PDPK1
type: Protein
entity reference: PDPK1
feature: S241 PDPK1 s1669 sa163 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re59 707
type: Stoichiometry
physical entity: p52 SHC1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re59 708
type: Stoichiometry
physical entity: p52 SHC1 s721 sa101
stoichiometric coefficient: 1.0

IRS1 / PI3K association
type: Complex
component stoichiometry: IRS1 s933 sa295 STOICHIOMETRY ID COMPLEX
component stoichiometry: PI3K Class I s984 csa32 STOICHIOMETRY ID COMPLEX
component: IRS1
component: PI3K Class I
feature: COMPLEX BINDING FEATURE s1936 csa19 429
feature: COMPLEX BINDING FEATURE s1936 csa19 431
cellular location: CELL

HBEGF
type: Protein
feature: ACTIVE 13
comment: SPECIES_TYPE=PROTEIN

Dynamin-1
type: ProteinReference
xref: uniprot Q05193 83
xref: PTHR11566:SF32
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__L_Arg-RIGHT__NO-_L_Citrulline-_re354
controller: NOS1

S722 RPTOR s643 sa312 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S722
feature location: S722 RPTOR s643 sa312 rs3 S722
comment: MODIFICATION_RESIDUE_ANGLE=2.378634437717986
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S722

HuR
type: DnaRegion
entity reference: HuR
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

Y580 SHP 2 s1441 sa634 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y580
feature location: Y580 SHP 2 s1441 sa634 rs1 Y580
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.781719483475212
comment: MODIFICATION_RESIDUE_NAME=Y580

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38MAPK-RIGHT__p38MAPK-_re155
controller: CCK1R

PTHR11532:SF62
type: RelationshipXref
id: PTHR11532:SF62
db: PANTHER Family
relationship type: By Homology

PTHR19304:SF9
type: RelationshipXref
id: PTHR19304:SF9
db: PANTHER Family
relationship type: By Homology

T443 CCK2R s1660 sa22 rs11
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T443
feature location: T443 CCK2R s1660 sa22 rs11 T443
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T443
comment: MODIFICATION_RESIDUE_ANGLE=0.25278736068041796

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot P29353 31
organism: Homo sapiens

S307 CCK1R s866 sa458 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S307
feature location: S307 CCK1R s866 sa458 rs3 S307
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.912135572113799
comment: MODIFICATION_RESIDUE_NAME=S307

S706 PRKD2 s774 sa735 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S706
feature location: S706 PRKD2 s774 sa735 rs2 S706
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S706
comment: MODIFICATION_RESIDUE_ANGLE=0.8559137879749282

S37 beta catenin s1862 sa635 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S37
feature location: S37 beta catenin s1862 sa635 rs1 S37
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S37

CaN
type: Protein
entity reference: CaN
feature: COMPLEX PARTICIPANT BINDING FEATURE s2014 sa1011 424
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y239 240 p66 SHC1 s713 sa102 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y239 240
feature location: Y239 240 p66 SHC1 s713 sa102 rs2 Y239 240
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3469545117994337
comment: MODIFICATION_RESIDUE_NAME=Y239/240

FOS
type: ProteinReference
xref: P07035
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.FOS
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Proto-oncogene c-Fos

PTHR24418:SF407
type: RelationshipXref
id: PTHR24418:SF407
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re539 993
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re539 994
type: Stoichiometry
physical entity: FOS
stoichiometric coefficient: 1.0

T180 p38MAPK s144 sa225 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T180
feature location: T180 p38MAPK s144 sa225 rs2 T180
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T180
comment: MODIFICATION_RESIDUE_ANGLE=5.470355957928183

Paxillin
type: Protein
entity reference: Paxillin
feature: Y118 Paxillin s671 sa114 rs2
feature: Y31 Paxillin s671 sa114 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

G17 s1689 sa566 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G17
stoichiometric coefficient: 1.0

uniprot P32239 22
type: UnificationXref
id: P32239
db: uniprot

Y118 Paxillin s672 sa119 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y118
feature location: Y118 Paxillin s672 sa119 rs2 Y118
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=Y118
comment: MODIFICATION_RESIDUE_ANGLE=5.490568410662676
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PARTICIPANT STOICHIOMETRY re22 864
type: Stoichiometry
physical entity: Conventional PKC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 865
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

SRC @Galphaq
type: Protein
entity reference: SRC @Galphaq
feature: Y527 SRC @Galphaq s719 sa95 rs2
feature: ACTIVE 13
feature: Y418 SRC @Galphaq s719 sa95 rs3
feature: Y416 SRC @Galphaq s719 sa95 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PRKD1-RIGHT__PRKD1-_re27
controller: PKC

TACR1
type: RnaRegion
entity reference: TACR1
cellular location: CELL
comment: SPECIES_TYPE=RNA

YES1
type: Protein
entity reference: YES1
feature: ACTIVE 13
feature: Y416 YES1 s1995 sa984 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

COX2
type: RnaRegion
entity reference: COX2
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

S706 PRKD2 s1388 sa736 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S706
feature location: S706 PRKD2 s1388 sa736 rs2 S706
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S706
comment: MODIFICATION_RESIDUE_ANGLE=0.8559137879749282

S221 RSK1 2 s546 sa329 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 RSK1 2 s546 sa329 rs5 S221
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=3.8909266156067464
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Paxillin-RIGHT__Paxillin-_re70
controller: FAK1-SRC-p190GEF complex

uniprot P41240 97
type: UnificationXref
id: P41240
db: uniprot

PARTICIPANT STOICHIOMETRY re252 682
type: Stoichiometry
physical entity: VMAT2
stoichiometric coefficient: 1.0

uniprot Q04759 35
type: UnificationXref
id: Q04759
db: uniprot

PARTICIPANT STOICHIOMETRY re252 681
type: Stoichiometry
physical entity: VMAT2
stoichiometric coefficient: 1.0

BCL2
type: ProteinReference
xref: P07059
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.BCL2
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Apoptosis regulator Bcl-2

S430 CCK1R s866 sa458 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S430
feature location: S430 CCK1R s866 sa458 rs4 S430
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.556558434920722
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S430

p110
type: Protein
entity reference: p110
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S33 beta catenin s1274 sa636 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S33
feature location: S33 beta catenin s1274 sa636 rs2 S33
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7304919088134321
comment: MODIFICATION_RESIDUE_NAME=S33

uniprot P17252 19
type: UnificationXref
id: P17252
db: uniprot

GAS-REBP3
type: Protein
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

S82 CCK2R s1410 sa568 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S82
feature location: S82 CCK2R s1410 sa568 rs2 S82
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.827433388230814
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S82

PARTICIPANT STOICHIOMETRY re122 1063
type: Stoichiometry
physical entity: PRAS40
stoichiometric coefficient: 1.0

Y783 PLCgamma1 s1622 sa903 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y783
feature location: Y783 PLCgamma1 s1622 sa903 rs3 Y783
comment: MODIFICATION_RESIDUE_ANGLE=0.7540866087105068
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y783

IP3
type: SmallMolecule
cellular location: CELL
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CCK
type: Protein
entity reference: CCK
feature: COMPLEX PARTICIPANT BINDING FEATURE s1910 sa946 200
feature: ACTIVE 13
feature: Y91 CCK s1910 sa946 rs2
feature: Y94 CCK s1910 sa946 rs3
feature: Y77 CCK s1910 sa946 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAPK3-RIGHT__MAPK3-_re142
controller: MAP2K2

CREB1
type: Protein
entity reference: CREB1
feature: S133 CREB1 s187 sa331 rs1
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

T440 CCK2R s1369 sa563 rs8
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T440
feature location: T440 CCK2R s1369 sa563 rs8 T440
comment: MODIFICATION_RESIDUE_ANGLE=5.06610690323832
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T440

PARTICIPANT STOICHIOMETRY re122 1064
type: Stoichiometry
physical entity: PRAS40
stoichiometric coefficient: 1.0

Y925 FAK1 s668 sa118 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y925
feature location: Y925 FAK1 s668 sa118 rs6 Y925
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.95
comment: MODIFICATION_RESIDUE_NAME=Y925

CaM s695 sa1002 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CaM
stoichiometric coefficient: 1.0

uniprot Q96CW1 104
type: UnificationXref
id: Q96CW1
db: uniprot

Proheparin-binding EGF-like growth factor
type: DnaReference
xref: PTHR10740:SF4
organism: Homo sapiens

JUN
type: DnaRegion
entity reference: JUN
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Signal_pre_pro_CCK-RIGHT__Pre_pro_CCK_@_ER-_re301
controller: Signalase

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__NR4A1-RIGHT__NR4A1-_re445
control type: INHIBITION
controller: HDAC7

STATE_TRANSITION_LEFT__CCK_GRR-RIGHT__CCK_G-_re305
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re305 625
participant stoichiometry: PARTICIPANT STOICHIOMETRY re305 624
left: CCK-GRR
interaction type: STATE_TRANSITION
right: CCK-G

Prohormone convertase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re444 1166
type: Stoichiometry
physical entity: IL8
stoichiometric coefficient: 1.0

COX2
type: DnaRegionReference
member entity reference: Prostaglandin G/H synthase 2
xref: G07292
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.COX2
comment: ENTITY_REFERENCE_NOTES=

PARTICIPANT STOICHIOMETRY re444 1167
type: Stoichiometry
physical entity: HuR
stoichiometric coefficient: 1.0

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
type: ProteinReference
xref: uniprot P54750 144
xref: PTHR11347:SF34
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re444 1168
type: Stoichiometry
physical entity: HuR-IL8
stoichiometric coefficient: 1.0

PLCbeta
type: Protein
feature: PLCbeta s1692 sa11 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S63 JUN s192 sa338 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S63
feature location: S63 JUN s192 sa338 rs1 S63
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8251814037002603
comment: MODIFICATION_RESIDUE_NAME=S63

T71 ATF2 s1012 sa753 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T71
feature location: T71 ATF2 s1012 sa753 rs2 T71
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5248232251383325
comment: MODIFICATION_RESIDUE_NAME=T71

S256 FOXO1 s1624 sa900 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S256
feature location: S256 FOXO1 s1624 sa900 rs1 S256
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S256
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3089902527502986

T505 PKCdelta s1339 sa6 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T505
feature location: T505 PKCdelta s1339 sa6 rs1 T505
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.6716181477744779
comment: MODIFICATION_RESIDUE_NAME=T505

p52SHC1-GRB2-SOS1
type: Complex
component stoichiometry: GRB2 s914 sa275 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS1 s946 sa273 STOICHIOMETRY ID COMPLEX
component stoichiometry: p52 SHC1 s899 sa274 STOICHIOMETRY ID COMPLEX
component: SOS1
component: p52 SHC1
component: GRB2
feature: COMPLEX BINDING FEATURE s1926 csa10 267
feature: COMPLEX BINDING FEATURE s1926 csa10 269
feature: COMPLEX BINDING FEATURE s1926 csa10 265
cellular location: CELL

STATE_TRANSITION_LEFT__HRAS_GTP-RIGHT__HRAS_GDP-_Pi-_re632
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re632 746
participant stoichiometry: PARTICIPANT STOICHIOMETRY re632 744
participant stoichiometry: PARTICIPANT STOICHIOMETRY re632 745
left: HRAS-GTP
interaction type: STATE_TRANSITION
right: Pi
right: HRAS-GDP

PDE
type: Protein
entity reference: PDE
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CHGA
type: DnaRegion
entity reference: CHGA
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

PTHR24057:SF8
type: RelationshipXref
id: PTHR24057:SF8
db: PANTHER Family
relationship type: By Homology

cGK 1
type: Protein
entity reference: cGK 1
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Protein synthesis
type: Pathway

MAP3K14
type: Protein
entity reference: MAP3K14
feature: T559 MAP3K14 s863 sa60 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S63 JUN s1050 sa349 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S63
feature location: S63 JUN s1050 sa349 rs1 S63
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8251814037002603
comment: MODIFICATION_RESIDUE_NAME=S63

SOS1 s943 sa272 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PI4,5_P2-RIGHT__PI3,4,5_P3-_re103
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re103 1136
participant stoichiometry: PARTICIPANT STOICHIOMETRY re103 1135
left: PI4,5-P2
interaction type: STATE_TRANSITION
right: PI3,4,5-P3

IP3R s1541 sa8 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3744879256752047
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re376 1216
type: Stoichiometry
physical entity: SNAI1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re376 1217
type: Stoichiometry
physical entity: SNAI1
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__HRAS_GDP-_GTP-RIGHT__HRAS_GTP-_GDP-_re156
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re156 940
participant stoichiometry: PARTICIPANT STOICHIOMETRY re156 942
participant stoichiometry: PARTICIPANT STOICHIOMETRY re156 941
participant stoichiometry: PARTICIPANT STOICHIOMETRY re156 939
left: GTP
left: HRAS-GDP
interaction type: STATE_TRANSITION
right: GDP
right: HRAS-GTP

Regeneration hypoplasia
type: Pathway

PARTICIPANT STOICHIOMETRY re632 744
type: Stoichiometry
physical entity: HRAS-GTP
stoichiometric coefficient: 1.0

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31749 127
xref: PTHR24356:SF171
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re632 745
type: Stoichiometry
physical entity: HRAS-GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re632 746
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

CaM
type: Protein
entity reference: CaM
feature: COMPLEX PARTICIPANT BINDING FEATURE s695 sa1002 416
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PAI1
type: RnaRegion
entity reference: PAI1
cellular location: CELL
comment: SPECIES_TYPE=RNA

PLCbeta s1692 sa639 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=0.7946381417903594
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re108 1124
type: Stoichiometry
physical entity: PDK1-PIP3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re108 1123
type: Stoichiometry
physical entity: PI3,4,5-P3
stoichiometric coefficient: 1.0

PTHR12693:SF3
type: RelationshipXref
id: PTHR12693:SF3
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re108 1122
type: Stoichiometry
physical entity: PDPK1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PI4,5_P2-RIGHT__DAG-_IP3-_re2
controller: PLCbeta

Radiation-inducible immediate-early gene IEX-1
type: ProteinReference
xref: PTHR16915:SF0
xref: uniprot P46695 55
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re619 827
type: Stoichiometry
physical entity: s1787
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re619 826
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re251 687
type: Stoichiometry
physical entity: CHGA
stoichiometric coefficient: 1.0

Galpha13
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s139 sa574 480
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

STAT3 s1785 sa325 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT3
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re251 686
type: Stoichiometry
physical entity: CHGA
stoichiometric coefficient: 1.0

s855
type: PhysicalEntity
cellular location: Lysosome
comment: SPECIES_TYPE=DEGRADED

T71 ATF2 s1051 sa350 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T71
feature location: T71 ATF2 s1051 sa350 rs2 T71
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5248232251383325
comment: MODIFICATION_RESIDUE_NAME=T71

MMP9
type: DnaRegion
entity reference: MMP9
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__MCL1-RIGHT__MCL1-_re455
controller: ELK1

CCND1
type: RnaRegion
entity reference: CCND1
cellular location: CELL
comment: SPECIES_TYPE=RNA

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__EGR1-RIGHT__EGR1-_re629
controller: MAPK1/3

RSK1/2
type: ProteinReference
xref: P07153
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.RSK1/2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Ribosomal protein S6 kinase alpha-3
member entity reference: Ribosomal protein S6 kinase alpha-1

T2446 mTOR s958 sa316 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T2446
feature location: T2446 mTOR s958 sa316 rs4 T2446
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T2446
comment: MODIFICATION_RESIDUE_ANGLE=2.3667132155949893

S259 RAF1 s731 sa687 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S259
feature location: S259 RAF1 s731 sa687 rs3 S259
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S259
comment: MODIFICATION_RESIDUE_ANGLE=2.328231397687482

STATE_TRANSITION_LEFT__SHC-RIGHT__SHC3-_re525
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re525 1044
participant stoichiometry: PARTICIPANT STOICHIOMETRY re525 1043
left: SHC
interaction type: STATE_TRANSITION
right: SHC3 s710 sa105

CATALYSIS
type: Catalysis
controlled: TRANSPORT_LEFT__active_CCK2R_beta_arrestin_complex-RIGHT__active_CCK2R_Beta_arrestin_complex-_re332
controller: Dynamin

TRANSLATION_LEFT__ITGB1-RIGHT__ITGB1-_re589
type: TemplateReaction
product: ITGB1
xref: TRANSLATION
participant: ITGB1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

S259 RAF1 s155 sa679 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S259
feature location: S259 RAF1 s155 sa679 rs3 S259
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S259
comment: MODIFICATION_RESIDUE_ANGLE=2.328231397687482

uniprot P53779 70
type: UnificationXref
id: P53779
db: uniprot

STATE_TRANSITION_LEFT__CCK1R__active_-RIGHT__CCK1R__inactive_-_re287
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re287 569
participant stoichiometry: PARTICIPANT STOICHIOMETRY re287 570
left: CCK1R (active)
interaction type: STATE_TRANSITION
right: CCK1R (inactive)

Y182 p38MAPK s998 sa227 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y182
feature location: Y182 p38MAPK s998 sa227 rs1 Y182
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y182
comment: MODIFICATION_RESIDUE_ANGLE=0.84

KNOWN_TRANSITION_OMITTED_LEFT__p60_SRC-RIGHT__SRC_@Galphaq-_re575
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re575 847
participant stoichiometry: PARTICIPANT STOICHIOMETRY re575 846
left: p60 SRC
interaction type: KNOWN_TRANSITION_OMITTED
right: SRC @Galphaq

STATE_TRANSITION_LEFT__MAPK8_10-RIGHT__MAPK8_10-_re152
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re152 948
participant stoichiometry: PARTICIPANT STOICHIOMETRY re152 947
left: MAPK8-10
interaction type: STATE_TRANSITION
right: MAPK8-10

uniprot P15336 166
type: UnificationXref
id: P15336
db: uniprot

SRC @Galphaq
type: Protein
entity reference: SRC @Galphaq
feature: Y418 SRC @Galphaq s718 sa94 rs3
feature: Y527 SRC @Galphaq s718 sa94 rs2
feature: Y416 SRC @Galphaq s718 sa94 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re78 643
type: Stoichiometry
physical entity: CDC42-GDP
stoichiometric coefficient: 1.0

Y725 STAT3 s675 sa180 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y725
feature location: Y725 STAT3 s675 sa180 rs2 Y725
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.583002134385839
comment: MODIFICATION_RESIDUE_NAME=Y725
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PARTICIPANT STOICHIOMETRY re78 644
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re78 645
type: Stoichiometry
physical entity: CDC42-GTP
stoichiometric coefficient: 1.0

NOS1
type: Protein
entity reference: NOS1
feature: S847 NOS1 s1268 sa631 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S82 HSP27 s1586 sa873 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S82
feature location: S82 HSP27 s1586 sa873 rs3 S82
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7447925440653353
comment: MODIFICATION_RESIDUE_NAME=S82

FAK1-SRC complex
type: Complex
component stoichiometry: p60 SRC s963 sa286 STOICHIOMETRY ID COMPLEX
component stoichiometry: FAK1 s776 sa285 STOICHIOMETRY ID COMPLEX
component: FAK1
component: p60 SRC
feature: COMPLEX BINDING FEATURE s1946 csa14 367
feature: COMPLEX BINDING FEATURE s1946 csa14 369
cellular location: CELL

PARTICIPANT STOICHIOMETRY re78 642
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

GTP s1775 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

MCL1
type: RnaRegion
entity reference: MCL1
cellular location: CELL
comment: SPECIES_TYPE=RNA

TRANSLATION_LEFT__ITGAV-RIGHT__ITGAV-_re594
type: TemplateReaction
product: ITGAV
xref: TRANSLATION
participant: ITGAV s1636 sa911
participant: ITGAV
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

ACAT1
type: RnaRegion
entity reference: ACAT1
cellular location: CELL
comment: SPECIES_TYPE=RNA

STATE_TRANSITION_LEFT__SRC_@Galphaq-RIGHT__SRC_@Galphaq-_re52
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re52 725
participant stoichiometry: PARTICIPANT STOICHIOMETRY re52 726
left: SRC @Galphaq
interaction type: STATE_TRANSITION
right: SRC @Galphaq

Y332 CAS s766 sa287 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y332
feature location: Y332 CAS s766 sa287 rs3 Y332
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y332
comment: MODIFICATION_RESIDUE_ANGLE=3.809181092477624

T359 RSK1 2 s536 sa209 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T359
feature location: T359 RSK1 2 s536 sa209 rs2 T359
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_NAME=T359
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.7908334448050431

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__CAS-_CRK-RIGHT__CAS_CRK_complex-_re72
controller: FAK1-SRC complex

CCK1R s866 sa458 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CCK1R
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: DISSOCIATION LEFT GTP- G Protein complex-RIGHT Gbeta gamma- GDP- Galpha q complex- re480
controller: CCK1R

PARTICIPANT STOICHIOMETRY re479 1083
type: Stoichiometry
physical entity: G34-Gly
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re176 862
type: Stoichiometry
physical entity: RAF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re176 863
type: Stoichiometry
physical entity: c-RAF / RAF1
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__beta_catenin-RIGHT__beta_catenin-_re365
controller: GSK3beta

FAK2
type: Protein
entity reference: FAK2
feature: Y402 FAK2 s1591 sa878 rs1
feature: Y579 FAK2 s1591 sa878 rs2
feature: ACTIVE 13
feature: Y580 FAK2 s1591 sa878 rs3
feature: COMPLEX PARTICIPANT BINDING FEATURE s1591 sa878 276
feature: Y881 FAK2 s1591 sa878 rs4
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S1261 mTOR s644 sa311 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S1261
feature location: S1261 mTOR s644 sa311 rs1 S1261
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S1261
comment: MODIFICATION_RESIDUE_ANGLE=5.501842555985567

uniprot O43524 58
type: UnificationXref
id: O43524
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD_PLUS_-RIGHT__cADPR-_re357
controller: CD38

ACAT1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.ACAT1
comment: ENTITY_REFERENCE_NOTES=

S257 MAP2K4 s995 sa219 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S257
feature location: S257 MAP2K4 s995 sa219 rs1 S257
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S257
comment: MODIFICATION_RESIDUE_ANGLE=0.73

RAF1
type: Protein
entity reference: RAF1
feature: T268 9 RAF1 s731 sa687 rs7
feature: S338 RAF1 s731 sa687 rs1
feature: S497 9 RAF1 s731 sa687 rs8
feature: S259 RAF1 s731 sa687 rs3
feature: S494 RAF1 s731 sa687 rs5
feature: S43 RAF1 s731 sa687 rs6
feature: Y341 RAF1 s731 sa687 rs2
feature: T491 RAF1 s731 sa687 rs4
feature: S621 RAF1 s731 sa687 rs9
cellular location: RAF1 c11
comment: SPECIES_TYPE=PROTEIN

Ribosomal protein S6 kinase alpha-1
type: ProteinReference
xref: PTHR24351:SF43
xref: uniprot Q15418 120
organism: Homo sapiens

GTP s1183 sa491 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__p46_SHC1-RIGHT__p46_SHC1-_re60
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re60 701
participant stoichiometry: PARTICIPANT STOICHIOMETRY re60 702
left: p46 SHC1
interaction type: STATE_TRANSITION
right: p46 SHC1

Ryanodine receptor 3
type: ProteinReference
xref: uniprot Q15413 26
xref: PTHR13715:SF16
organism: Homo sapiens

S380 RSK1 2 s539 sa214 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S380
feature location: S380 RSK1 2 s539 sa214 rs4 S380
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=1.8133457596088143
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S380

PARTICIPANT STOICHIOMETRY re285 575
type: Stoichiometry
physical entity: CCK1R
stoichiometric coefficient: 1.0

p54 SRC
type: ProteinReference
xref: P07109
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.p54 SRC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Proto-oncogene tyrosine-protein kinase Src

S158 HuR s1007 sa727 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S158
feature location: S158 HuR s1007 sa727 rs1 S158
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.67
comment: MODIFICATION_RESIDUE_NAME=S158
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PARTICIPANT STOICHIOMETRY re285 576
type: Stoichiometry
physical entity: CCK s1780 sa949
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re295 560
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re295 561
type: Stoichiometry
physical entity: cAMP s1840 sa472
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re479 1082
type: Stoichiometry
physical entity: Progastrin @Golgi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re285 574
type: Stoichiometry
physical entity: CCK-CCK1R
stoichiometric coefficient: 1.0

uniprot P62753 41
type: UnificationXref
id: P62753
db: uniprot

CaN
type: Protein
entity reference: CaN
feature: ACTIVE 13
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

BAX
type: Protein
entity reference: BAX
cellular location: Mitochondria
comment: SPECIES_TYPE=PROTEIN

KNOWN_TRANSITION_OMITTED_LEFT__Novel_PKC-RIGHT__PKCeta-_re18
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 895
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 894
left: Novel PKC
interaction type: KNOWN_TRANSITION_OMITTED
right: PKCeta

Y341 RAF1 s1336 sa692 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y341
feature location: Y341 RAF1 s1336 sa692 rs2 Y341
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y341
comment: MODIFICATION_RESIDUE_ANGLE=0.813361255902311

PRAS40
type: ProteinReference
xref: P07076
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.PROTEIN.GENERIC.PRAS40
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Proline-rich AKT1 substrate 1

Y881 FAK2 s1598 sa886 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y881
feature location: Y881 FAK2 s1598 sa886 rs4 Y881
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.5
comment: MODIFICATION_RESIDUE_NAME=Y881

STATE_TRANSITION_LEFT__SP1-RIGHT__SP1-_re195
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re195 779
participant stoichiometry: PARTICIPANT STOICHIOMETRY re195 780
left: SP1
interaction type: STATE_TRANSITION
right: SP1

NOS1
type: Protein
entity reference: NOS1
feature: ACTIVE 13
feature: S847 NOS1 s1267 sa628 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

S112 BAD s1612 sa892 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S112
feature location: S112 BAD s1612 sa892 rs1 S112
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.538835828280262
comment: MODIFICATION_RESIDUE_NAME=S112

G17
type: Protein
entity reference: G17
feature: ACTIVE 13
feature: COMPLEX PARTICIPANT BINDING FEATURE s1689 sa566 364
feature: Y G17 s1689 sa566 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Cytosolic phospholipase A2
type: ProteinReference
xref: uniprot P47712 111
xref: PTHR10728:SF13
organism: Homo sapiens

Nuclear receptor subfamily 2 group C member 2
type: ProteinReference
xref: uniprot P49116 117
xref: PTHR24083:SF48
organism: Homo sapiens

Cadherin-1
type: DnaReference
organism: Homo sapiens

S621 RAF1 s1721 sa694 rs9
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S621
feature location: S621 RAF1 s1721 sa694 rs9 S621
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S621
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.46201537231871

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GSK3beta-RIGHT__GSK3beta-_re369
controller: PAK1

KNOWN_TRANSITION_OMITTED_LEFT__ROCK1-RIGHT__BCL2L1-_re591
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re591 769
participant stoichiometry: PARTICIPANT STOICHIOMETRY re591 770
left: ROCK1
interaction type: KNOWN_TRANSITION_OMITTED
right: BCL2L1

Y416 SRC s107 sa677 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y416
feature location: Y416 SRC s107 sa677 rs1 Y416
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y416
comment: MODIFICATION_RESIDUE_ANGLE=2.3695516018147504

HRAS s1805 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: HRAS
stoichiometric coefficient: 1.0

TRANSCRIPTION_LEFT__MCL1-RIGHT__MCL1-_re455
type: TemplateReaction
product: MCL1
xref: TRANSCRIPTION
participant: MCL1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY re560 908
type: Stoichiometry
physical entity: BCL2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re560 909
type: Stoichiometry
physical entity: BAX/BCL2 heterodimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re560 907
type: Stoichiometry
physical entity: BAX
stoichiometric coefficient: 2.0

T573 RSK1 2 s539 sa214 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T573
feature location: T573 RSK1 2 s539 sa214 rs3 T573
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=T573

BIRC2
type: DnaRegion
entity reference: BIRC2
cellular location: NUCLEUS
comment: SPECIES_TYPE=GENE

NR4A1
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.NR4A1
comment: ENTITY_REFERENCE_NOTES=

STATE_TRANSITION_LEFT__L_Arg-RIGHT__NO-_L_Citrulline-_re354
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re354 531
participant stoichiometry: PARTICIPANT STOICHIOMETRY re354 532
participant stoichiometry: PARTICIPANT STOICHIOMETRY re354 530
left: L-Arg
interaction type: STATE_TRANSITION
right: NO
right: L-Citrulline

MAP3K11
type: Protein
entity reference: MAP3K11
feature: S281 MAP3K11 s961 sa221 rs2
feature: T277 MAP3K11 s961 sa221 rs1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

Y925 FAK1 s669 sa111 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y925
feature location: Y925 FAK1 s669 sa111 rs6 Y925
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.95
comment: MODIFICATION_RESIDUE_NAME=Y925

Gbeta/gamma
type: Protein
entity reference: Gbeta/gamma
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PTHR24418:SF78
type: RelationshipXref
id: PTHR24418:SF78
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__B_Raf-RIGHT__B_Raf-_re172
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re172 875
participant stoichiometry: PARTICIPANT STOICHIOMETRY re172 874
left: B-Raf
interaction type: STATE_TRANSITION
right: B-Raf

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MAP2K2-RIGHT__MAP2K2-_re141
controller: RAF1

PARTICIPANT STOICHIOMETRY re592 763
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

MOB1
type: RnaRegion
entity reference: MOB1
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re592 764
type: Stoichiometry
physical entity: JUN
stoichiometric coefficient: 1.0

T439 CCK2R s1235 sa558 rs6
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T439
feature location: T439 CCK2R s1235 sa558 rs6 T439
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.751588888718252
comment: MODIFICATION_RESIDUE_NAME=T439

PP2B
type: Protein
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION_LEFT__NFKB1_RELA_IKB_complex-RIGHT__NFKB_RELA_heterodimer-_IKBalpha-_re384
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re384 1192
participant stoichiometry: PARTICIPANT STOICHIOMETRY re384 1191
participant stoichiometry: PARTICIPANT STOICHIOMETRY re384 1190
left: NFKB1-RELA-IKB complex
interaction type: DISSOCIATION
right: NFKB/RELA heterodimer
right: IKBalpha

PARTICIPANT STOICHIOMETRY re586 800
type: Stoichiometry
physical entity: AKT1-PIP3
stoichiometric coefficient: 1.0

PI3,4,5 P3 s912 sa304 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3,4,5-P3
stoichiometric coefficient: 1.0

T277 MAP3K11 s961 sa221 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T277
feature location: T277 MAP3K11 s961 sa221 rs1 T277
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=0.79
comment: MODIFICATION_RESIDUE_NAME=T277
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

PTHR10583:SF1
type: RelationshipXref
id: PTHR10583:SF1
db: PANTHER Family
relationship type: By Homology

Y77 CCK s1779 sa948 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y77
feature location: Y77 CCK s1779 sa948 rs1 Y77
modification type: sulfated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.3832305715485393
comment: MODIFICATION_RESIDUE_NAME=Y77

S136 BAD s1615 sa893 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S136
feature location: S136 BAD s1615 sa893 rs2 S136
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8079058030724882
comment: MODIFICATION_RESIDUE_NAME=S136

JUN
type: Protein
entity reference: JUN
feature: S63 JUN s192 sa338 rs1
feature: ACTIVE 13
feature: S73 JUN s192 sa338 rs2
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

Proto-oncogene tyrosine-protein kinase Src
type: ProteinReference
xref: PTHR24418:SF53
xref: uniprot P12931 100
organism: Homo sapiens

Proto-oncogene c-Fos
type: ProteinReference
xref: uniprot P01100 154
xref: PTHR23351:SF4
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re519 1074
type: Stoichiometry
physical entity: 14-3-3 beta/alpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re519 1073
type: Stoichiometry
physical entity: RAF1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re519 1072
type: Stoichiometry
physical entity: c-RAF/14-3-3 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re304 629
type: Stoichiometry
physical entity: Pro-CCK @ secretory granule
stoichiometric coefficient: 1.0

RELA p65 s1682 sa328 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RELA (p65)
stoichiometric coefficient: 1.0

uniprot Q15382 64
type: UnificationXref
id: Q15382
db: uniprot

S221 RSK1 2 s538 sa212 rs5
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S221
feature location: S221 RSK1 2 s538 sa212 rs5 S221
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_ANGLE=3.8909266156067464
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S221

GDP s1803 sa74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 911
type: Stoichiometry
physical entity: PKCdelta
stoichiometric coefficient: 1.0

S307 CCK1R s1485 sa456 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S307
feature location: S307 CCK1R s1485 sa456 rs3 S307
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.912135572113799
comment: MODIFICATION_RESIDUE_NAME=S307

PARTICIPANT STOICHIOMETRY re15 910
type: Stoichiometry
physical entity: Novel PKC
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: PTHR48013:SF12
xref: uniprot P52564 174
organism: Homo sapiens

uniprot Q8WUI4 130
type: UnificationXref
id: Q8WUI4
db: uniprot

UNKNOWN_CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__FOS-_JUN-RIGHT__AP1__FOS_PLUS_JUN_-_re450
controller: NFKB1/RELA heterodimer

PARTICIPANT STOICHIOMETRY re304 630
type: Stoichiometry
physical entity: CCK-GRR
stoichiometric coefficient: 1.0

IKKalpha
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s1814 sa263 474
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

ITGB1
type: RnaRegion
entity reference: ITGB1
cellular location: CELL
comment: SPECIES_TYPE=RNA

PARTICIPANT STOICHIOMETRY re663 627
type: Stoichiometry
physical entity: G17
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re663 628
type: Stoichiometry
physical entity: CCK2R
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re663 626
type: Stoichiometry
physical entity: CCK2R
stoichiometric coefficient: 1.0

PTHR24418:SF94
type: RelationshipXref
id: PTHR24418:SF94
db: PANTHER Family
relationship type: By Homology

PTHR22988:SF33
type: RelationshipXref
id: PTHR22988:SF33
db: PANTHER Family
relationship type: By Homology

PTHR24418:SF90
type: RelationshipXref
id: PTHR24418:SF90
db: PANTHER Family
relationship type: By Homology

Y185 MAPK8 10 s665 sa222 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y185
feature location: Y185 MAPK8 10 s665 sa222 rs2 Y185
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=Y185
comment: MODIFICATION_RESIDUE_ANGLE=5.55783770758315

PRAS40
type: Protein
entity reference: PRAS40
feature: S221 PRAS40 s648 sa176 rs4
feature: S183 PRAS40 s648 sa176 rs1
feature: S212 PRAS40 s648 sa176 rs3
feature: T246 PRAS40 s648 sa176 rs2
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re506 1107
type: Stoichiometry
physical entity: CXCL2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re506 1108
type: Stoichiometry
physical entity: CXCL2
stoichiometric coefficient: 1.0

Y397 FAK1 s668 sa118 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY Y397
feature location: Y397 FAK1 s668 sa118 rs1 Y397
comment: MODIFICATION_RESIDUE_ANGLE=5.47
comment: MODIFICATION_RESIDUE_NAME=Y397
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue

S281 MAP3K11 s994 sa218 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S281
feature location: S281 MAP3K11 s994 sa218 rs2 S281
comment: MODIFICATION_RESIDUE_NAME=S281
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.59771503510726

CHGA
type: RnaRegion
entity reference: CHGA RNA
cellular location: NUCLEUS
comment: SPECIES_TYPE=RNA

UNKNOWN_TRANSITION_LEFT__RHOA_GTP-RIGHT__AKT1_PIP3-_re585
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re585 802
participant stoichiometry: PARTICIPANT STOICHIOMETRY re585 801
left: RHOA-GTP
interaction type: UNKNOWN_TRANSITION
right: AKT1-PIP3

Histidine decarboxylase
type: DnaReference
xref: PTHR11999:SF68
organism: Homo sapiens

STATE_TRANSITION_LEFT__SHP_2-RIGHT__SHP_2-_re487
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re487 1053
participant stoichiometry: PARTICIPANT STOICHIOMETRY re487 1054
left: SHP-2
interaction type: STATE_TRANSITION
right: SHP-2

S63 JUN s191 sa236 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S63
feature location: S63 JUN s191 sa236 rs1 S63
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.8251814037002603
comment: MODIFICATION_RESIDUE_NAME=S63

uniprot Q07812 88
type: UnificationXref
id: Q07812
db: uniprot

uniprot Q06124 128
type: UnificationXref
id: Q06124
db: uniprot

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__FOS-RIGHT__FOS-_re206
controller: SRF

STATE_TRANSITION_LEFT__FOXO1-RIGHT__FOXO1-_re581
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re581 815
participant stoichiometry: PARTICIPANT STOICHIOMETRY re581 816
left: FOXO1
interaction type: STATE_TRANSITION
right: FOXO1

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__HDC-RIGHT__HDC-_re437
control type: INHIBITION
controller: KLF4

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SHP_2-RIGHT__SHP_2-_re358
controller: CCK1R

RELA p65 s1748 sa265 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RELA (p65)
stoichiometric coefficient: 1.0

S37 beta catenin s1274 sa636 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S37
feature location: S37 beta catenin s1274 sa636 rs1 S37
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S37

JUN
type: Protein
entity reference: JUN
feature: S63 JUN s1041 sa340 rs1
feature: ACTIVE 13
feature: S73 JUN s1041 sa340 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s1041 sa340 216
cellular location: NUCLEUS
comment: SPECIES_TYPE=PROTEIN

TRANSLATION_LEFT__VMAT2-RIGHT__VMAT2-_re600
type: TemplateReaction
product: VMAT2
xref: TRANSLATION
participant: VMAT2
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

T573 RSK1 2 s546 sa329 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T573
feature location: T573 RSK1 2 s546 sa329 rs3 T573
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=outside
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.493279837249011
comment: MODIFICATION_RESIDUE_NAME=T573

E cadherin s980 sa320 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: E-cadherin
stoichiometric coefficient: 1.0

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSLATION_LEFT__ODC1-RIGHT__ODC1-_re486
controller: EIF4E

FOS
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.RNA.RNA.FOS
comment: ENTITY_REFERENCE_NOTES=

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

cGK 1
type: Protein
entity reference: cGK 1
cellular location: CELL
comment: SPECIES_TYPE=PROTEIN

CAS s766 sa287 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CAS
stoichiometric coefficient: 1.0

CLU
type: DnaRegionReference
member entity reference: Clusterin
xref: G07284
comment: ENTITY_REFERENCE_ID_DESC=Gastrin_CCK2R_240212.GENE.GENE.CLU
comment: ENTITY_REFERENCE_NOTES=

mLST8 s1767 sa310 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mLST8
stoichiometric coefficient: 1.0

T491 RAF1 s156 sa686 rs4
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T491
feature location: T491 RAF1 s156 sa686 rs4 T491
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=T491
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.3986264000533355

CATALYSIS
type: TemplateReactionRegulation
xref: CATALYSIS
controlled: TRANSCRIPTION_LEFT__CCND1-RIGHT__CCND1-_re421
controller: beta-catenin/TCF-4

S36 p66 SHC1 s728 sa99 rs3
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S36
feature location: S36 p66 SHC1 s728 sa99 rs3 S36
comment: MODIFICATION_RESIDUE_ANGLE=5.520227091307779
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=S36

S434 CCK2R s1235 sa558 rs12
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S434
feature location: S434 CCK2R s1235 sa558 rs12 S434
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=4.078526462630984
comment: MODIFICATION_RESIDUE_NAME=S434

S253 FOXO3 s1621 sa901 rs2
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S253
feature location: S253 FOXO3 s1621 sa901 rs2 S253
comment: MODIFICATION_RESIDUE_NAME=S253
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.4291919098540697

CCK s1779 sa948 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CCK
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__beta_catenin-RIGHT__sa436_degraded-_re366
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re366 510
participant stoichiometry: PARTICIPANT STOICHIOMETRY re366 509
left: beta-catenin
interaction type: STATE_TRANSITION
right: sa436_degraded

PTHR45879:SF1
type: RelationshipXref
id: PTHR45879:SF1
db: PANTHER Family
relationship type: By Homology