Carnitine dehydratase
type: ProteinReference
xref: P02866
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Carnitine dehydratase Synonym: Synonym not specified Accession: P02866
comment: ENTITY_REFERENCE_ID_DESC=Carnitine metabolism.PROTEIN.GENERIC.Carnitine dehydratase
member entity reference: LP04613p
member entity reference: Succinate--hydroxymethylglutarate CoA-transferase
member entity reference: LOC100125578 protein

crotono-betaine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

L-carnitine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 7

D-carnitine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 10090 5
type: UnificationXref
id: 10090
db: ncbitaxon

ncbitaxon 9913 3
type: UnificationXref
id: 9913
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r2 14
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 10
type: Stoichiometry
physical entity: Oxidized acceptor
stoichiometric coefficient: 1.0

uniprot Q7TNE1 4
type: UnificationXref
id: Q7TNE1
db: uniprot

uniprot Q9VDL4 6
type: UnificationXref
id: Q9VDL4
db: uniprot

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r2 12
type: Stoichiometry
physical entity: L-carnitine
stoichiometric coefficient: 1.0

LP04613p
type: ProteinReference
xref: uniprot Q9VDL4 6
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r2 13
type: Stoichiometry
physical entity: crotono-betaine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 11
type: Stoichiometry
physical entity: butyrobetaine
stoichiometric coefficient: 1.0

Carnitine dehydratase
type: Protein
entity reference: Carnitine dehydratase
comment: SPECIES_TYPE=PROTEIN

Succinate--hydroxymethylglutarate CoA-transferase
type: ProteinReference
xref: uniprot Q7TNE1 4
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r3 9
type: Stoichiometry
physical entity: Reduced acceptor
stoichiometric coefficient: 1.0

butyrobetaine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r3 8
type: Stoichiometry
physical entity: crotono-betaine
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

uniprot A6QQD0 2
type: UnificationXref
id: A6QQD0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__L_carnitine-RIGHT__crotono_betaine-_H2O-_r2
controller: Carnitine dehydratase

Crotonobetaine reductase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Reduced acceptor
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r1 15
type: Stoichiometry
physical entity: D-carnitine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 16
type: Stoichiometry
physical entity: L-carnitine
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__crotono_betaine-_Reduced_acceptor-RIGHT__Oxidized_acceptor-_butyrobetaine-_r3
controller: Crotonobetaine reductase

Carnitine racemase
type: Protein
comment: SPECIES_TYPE=PROTEIN

P02866
type: UnificationXref
id: P02866
db: PANTHER Pathway Component

PANTHER Pathway P02733 1
type: UnificationXref
id: P02733
db: PANTHER Pathway

Bos taurus
type: BioSource
xref: ncbitaxon 9913 3

LOC100125578 protein
type: ProteinReference
xref: uniprot A6QQD0 2
organism: Bos taurus

STATE_TRANSITION_LEFT__crotono_betaine-_Reduced_acceptor-RIGHT__Oxidized_acceptor-_butyrobetaine-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 9
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 11
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 10
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 8
left: crotono-betaine
left: Reduced acceptor
interaction type: STATE_TRANSITION
right: butyrobetaine
right: Oxidized acceptor

Carnitine metabolism
type: Pathway
pathway component: STATE_TRANSITION_LEFT__D_carnitine-RIGHT__L_carnitine-_r1
pathway component: STATE_TRANSITION_LEFT__crotono_betaine-_Reduced_acceptor-RIGHT__Oxidized_acceptor-_butyrobetaine-_r3
pathway component: STATE_TRANSITION_LEFT__L_carnitine-RIGHT__crotono_betaine-_H2O-_r2
xref: PANTHER Pathway P02733 1
comment: MODEL_NOTES=The degradation of the quaternary amine carnitine which may function as a electron acceptor during anaerobic respiration. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__D_carnitine-RIGHT__L_carnitine-_r1
controller: Carnitine racemase

Mus musculus
type: BioSource
xref: ncbitaxon 10090 5

ncbitaxon 7227 7
type: UnificationXref
id: 7227
db: ncbitaxon

STATE_TRANSITION_LEFT__L_carnitine-RIGHT__crotono_betaine-_H2O-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 14
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 12
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 13
left: L-carnitine
interaction type: STATE_TRANSITION
right: H2O
right: crotono-betaine

STATE_TRANSITION_LEFT__D_carnitine-RIGHT__L_carnitine-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 15
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 16
left: D-carnitine
interaction type: STATE_TRANSITION
right: L-carnitine

Oxidized acceptor
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE