ACTIVE 10
type: EntityFeature
comment: Active state

Protein kinase subunit s9 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Protein kinase subunit
stoichiometric coefficient: 1.0

26S proteasome non-ATPase regulatory subunit 13
type: ProteinReference
xref: PTHR10539:SF0
xref: uniprot Q9WVJ2 119
organism: Mus musculus

Cell cycle
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Cdk2-_Cyclin_E-RIGHT__Complex__Cyclin_E_Cdk2_-_r26
pathway component: STATE_TRANSITION_LEFT__Cyclin_B-RIGHT__Cyclin_B-_r36
pathway component: HETERODIMER_ASSOCIATION_LEFT__Cyclin_D-_Cdk4_6-RIGHT__Complex__Cdk4_6__Cyclin_D_-_r27
pathway component: DISSOCIATION_LEFT__Complex__Protein_kinase_subunit_Cyclin_B_-RIGHT__Cyclin_B-_Protein_kinase_subunit-_r38
pathway component: DISSOCIATION_LEFT__Complex__Rb_E2F_-RIGHT__E2F-_Rb-_r25
pathway component: UNKNOWN_TRANSITION_LEFT__Complex__Protein_kinase_subunit_Cyclin_B_-RIGHT__Cyclin_B-_r39
pathway component: HETERODIMER_ASSOCIATION_LEFT__E2F-_Rb-RIGHT__Complex__Rb_E2F_-_r24
pathway component: STATE_TRANSITION_LEFT__Cyclin_B-RIGHT__a102_degraded-_r35
pathway component: STATE_TRANSITION_LEFT__APC_-_ATP-RIGHT__APC_-_ADP-_r29
pathway component: STATE_TRANSITION_LEFT__Pre_replication_Complex-RIGHT__Pre_replication_Complex-_r23
pathway component: HETERODIMER_ASSOCIATION_LEFT__Protein_kinase_subunit-_Cyclin_B-RIGHT__Complex__Protein_kinase_subunit_Cyclin_B_-_r28
pathway component: STATE_TRANSITION_LEFT__E2F-RIGHT__E2F-_r3
pathway component: STATE_TRANSITION_LEFT__Complex__Protein_kinase_subunit_Cyclin_B_-RIGHT__Complex__Protein_kinase_subunit_Cyclin_B_-_r31
xref: PANTHER Pathway P00013 1
comment: MODEL_NOTES=Panther Pathway: P00013 Cell_Cycle Pathway: An ordered series of events leading to replication of cells.

uniprot Q2KI42 89
type: UnificationXref
id: Q2KI42
db: uniprot

uniprot Q9LT08 113
type: UnificationXref
id: Q9LT08
db: uniprot

CCNE1 isoform 1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot A0A2I3TEU6 123
organism: Pan troglodytes

uniprot A0A2I3TEU6 123
type: UnificationXref
id: A0A2I3TEU6
db: uniprot

uniprot Q8IDW1 11
type: UnificationXref
id: Q8IDW1
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Rb_E2F_-RIGHT__E2F-_Rb-_r25
controller: Complex (Cdk4/6/ Cyclin D)

Cyclin E2
type: ProteinReference
xref: uniprot D3ZQ41 157
organism: Rattus norvegicus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 63

uniprot H9FY18 137
type: UnificationXref
id: H9FY18
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 76

uniprot Q38C86 97
type: UnificationXref
id: Q38C86
db: uniprot

G1/S-specific cyclin-E2
type: ProteinReference
xref: uniprot Q9Z238 164
organism: Mus musculus

uniprot P55036 81
type: UnificationXref
id: P55036
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 80

PARTICIPANT STOICHIOMETRY r28 213
type: Stoichiometry
physical entity: Protein kinase subunit
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r28 214
type: Stoichiometry
physical entity: Cyclin B
stoichiometric coefficient: 1.0

RPA3 isoform 1
type: ProteinReference
xref: uniprot H2QU67 6
xref: PTHR15114:SF1
organism: Pan troglodytes

Proteasome activator subunit 3
type: ProteinReference
xref: PTHR10660:SF4
xref: uniprot F6V8H8 41
organism: Xenopus tropicalis

uniprot O43242 68
type: UnificationXref
id: O43242
db: uniprot

Protein kinase subunit
type: ProteinReference
xref: P00482
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein kinase subunit Synonym: Synonym not specified Accession: P00482
comment: ENTITY_REFERENCE_ID_DESC=Cell cycle.PROTEIN.GENERIC.Protein_br_kinase_br_subunit
member entity reference: Protein kinase A regulatory subunit

PTHR10758:SF2
type: RelationshipXref
id: PTHR10758:SF2
db: PANTHER Family
relationship type: By Homology

PTHR15827:SF2
type: RelationshipXref
id: PTHR15827:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q9Z238 164
type: UnificationXref
id: Q9Z238
db: uniprot

26S proteasome non-ATPase regulatory subunit 3
type: ProteinReference
xref: uniprot P14685 72
xref: PTHR10758:SF2
organism: Mus musculus

Cyclin D
type: Protein
entity reference: Cyclin D
cellular location: Mid G sub 1 endsub c6
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r28 215
type: Stoichiometry
physical entity: Complex (Protein kinase subunit/Cyclin B)
stoichiometric coefficient: 1.0

Proteasome 26S subunit, non-ATPase 12
type: ProteinReference
xref: uniprot J9JHD9 55
xref: PTHR10855:SF1
organism: Canis lupus familiaris

uniprot B0BN93 21
type: UnificationXref
id: B0BN93
db: uniprot

uniprot Q4QCD7 98
type: UnificationXref
id: Q4QCD7
db: uniprot

26S proteasome non-ATPase regulatory subunit 3
type: ProteinReference
xref: PTHR10758:SF2
xref: uniprot O43242 68
organism: Homo sapiens

Proteasome activator complex subunit 3
type: ProteinReference
xref: uniprot P61289 83
xref: PTHR10660:SF4
organism: Homo sapiens

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 88

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 12

Uncharacterized protein
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot W4YTT9 120
organism: Strongylocentrotus purpuratus

uniprot Q964G0 145
type: UnificationXref
id: Q964G0
db: uniprot

PTHR10540:SF6
type: RelationshipXref
id: PTHR10540:SF6
db: PANTHER Family
relationship type: By Homology

uniprot D4AEH3 25
type: UnificationXref
id: D4AEH3
db: uniprot

PTHR10540:SF7
type: RelationshipXref
id: PTHR10540:SF7
db: PANTHER Family
relationship type: By Homology

G2/mitotic-specific cyclin-B
type: ProteinReference
xref: uniprot P42524 152
xref: PTHR10177:SF347
organism: Dictyostelium discoideum

uniprot F6TS39 38
type: UnificationXref
id: F6TS39
db: uniprot

26S proteasome non-ATPase regulatory subunit 11A
type: ProteinReference
xref: uniprot F6P3G4 37
xref: PTHR10678:SF6
organism: Danio rerio

PTHR12081:SF44
type: RelationshipXref
id: PTHR12081:SF44
db: PANTHER Family
relationship type: By Homology

G1/S-specific cyclin-D1
type: ProteinReference
xref: PTHR10177:SF67
xref: uniprot P25322 138
organism: Mus musculus

Proteasome activator complex subunit 3
type: ProteinReference
xref: PTHR10660:SF4
xref: uniprot P61290 84
organism: Mus musculus

S Phase c12
type: CellularLocationVocabulary
comment: S Phase

uniprot Q8WZY4 111
type: UnificationXref
id: Q8WZY4
db: uniprot

G1/S-specific cyclin-E1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot F1NQ71 124
organism: Gallus gallus

uniprot F1NQ71 124
type: UnificationXref
id: F1NQ71
db: uniprot

uniprot A0A2I3TPZ7 17
type: UnificationXref
id: A0A2I3TPZ7
db: uniprot

ncbitaxon 284812 66
type: UnificationXref
id: 284812
db: ncbitaxon

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 7

Protein kinase 6
type: ProteinReference
xref: uniprot Q8IDW1 11
organism: Plasmodium falciparum

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 42

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FUB1 49
xref: PTHR10540:SF7
organism: Monodelphis domestica

CdkC
type: Protein
entity reference: CdkC
cellular location: S Phase c12
comment: SPECIES_TYPE=PROTEIN

uniprot D3ZQ41 157
type: UnificationXref
id: D3ZQ41
db: uniprot

uniprot Q0P5D3 144
type: UnificationXref
id: Q0P5D3
db: uniprot

uniprot E2RPY9 32
type: UnificationXref
id: E2RPY9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10855:SF1
xref: uniprot F1NPQ0 33
organism: Gallus gallus

uniprot P42524 152
type: UnificationXref
id: P42524
db: uniprot

ncbitaxon 9031 27
type: UnificationXref
id: 9031
db: ncbitaxon

ncbitaxon 6239 161
type: UnificationXref
id: 6239
db: ncbitaxon

Late G sub 1 endsub c7
type: CellularLocationVocabulary
comment: Late G_sub_1_endsub_

E2F s7 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: E2F
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Complex__Protein_kinase_subunit_Cyclin_B_-RIGHT__Complex__Protein_kinase_subunit_Cyclin_B_-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 207
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 208
left: Complex (Protein kinase subunit/Cyclin B)
interaction type: STATE_TRANSITION
right: Complex (Protein kinase subunit/Cyclin B)

uniprot Q27368 156
type: UnificationXref
id: Q27368
db: uniprot

uniprot P24864 126
type: UnificationXref
id: P24864
db: uniprot

26S proteasome non-ATPase regulatory subunit 7 homolog A
type: ProteinReference
xref: uniprot O24412 59
xref: PTHR10540:SF7
organism: Arabidopsis thaliana

Proteasome 26S subunit, non-ATPase 11
type: ProteinReference
xref: PTHR10678:SF2
xref: uniprot E2RJ26 31
organism: Canis lupus familiaris

Proteasome 26S subunit, non-ATPase 4
type: ProteinReference
xref: PTHR10223:SF0
xref: uniprot A0A452DI44 20
organism: Bos taurus

Cyclin-dependent kinase 2-interacting protein
type: ProteinReference
xref: uniprot Q9D0V8 150
xref: PTHR15827:SF2
organism: Mus musculus

HETERODIMER_ASSOCIATION_LEFT__Cyclin_D-_Cdk4_6-RIGHT__Complex__Cdk4_6__Cyclin_D_-_r27
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 218
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 217
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 216
left: Cyclin D
left: Cdk4/6
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cdk4/6/ Cyclin D)

Proteasome 26S subunit, non-ATPase 4
type: ProteinReference
xref: uniprot A0A2I3TPZ7 17
xref: PTHR10223:SF7
organism: Pan troglodytes

ncbitaxon 7668 121
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot O00487 58
type: UnificationXref
id: O00487
db: uniprot

Proteasome
type: Protein
entity reference: Proteasome
cellular location: Mitosis c5
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot C3XXY6 23
organism: Branchiostoma floridae

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

26S proteasome non-ATPase regulatory subunit 12
type: ProteinReference
xref: uniprot Q9D8W5 112
xref: PTHR10855:SF1
organism: Mus musculus

Metaphase c10
type: CellularLocationVocabulary
comment: Metaphase

ncbitaxon 5664 99
type: UnificationXref
id: 5664
db: ncbitaxon

ATP
type: SmallMolecule
cellular location: Mitosis c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

G1/S-specific cyclin-E1
type: ProteinReference
xref: uniprot P24864 126
xref: PTHR10177:SF71
organism: Homo sapiens

G1/S-specific cyclin-E2
type: ProteinReference
xref: uniprot O96020 163
organism: Homo sapiens

uniprot H2Q584 136
type: UnificationXref
id: H2Q584
db: uniprot

ncbitaxon 7955 36
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot A0A1D5QZ01 13
type: UnificationXref
id: A0A1D5QZ01
db: uniprot

uniprot Q7KMP8 109
type: UnificationXref
id: Q7KMP8
db: uniprot

uniprot P47794 129
type: UnificationXref
id: P47794
db: uniprot

uniprot A0A2I3RPW4 147
type: UnificationXref
id: A0A2I3RPW4
db: uniprot

Proteasome 26S subunit, non-ATPase 12
type: ProteinReference
xref: PTHR10855:SF1
xref: uniprot F7CV41 47
organism: Ornithorhynchus anatinus

Cyclin B s77 a102 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

G1/S-specific cyclin-E1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot P47794 129
organism: Danio rerio

Cyclin E
type: Protein
entity reference: Cyclin E
cellular location: Late G sub 1 endsub c7
comment: SPECIES_TYPE=PROTEIN

uniprot F7GU42 135
type: UnificationXref
id: F7GU42
db: uniprot

uniprot Q5XIC6 106
type: UnificationXref
id: Q5XIC6
db: uniprot

26S proteasome non-ATPase regulatory subunit 13
type: ProteinReference
xref: uniprot Q9UNM6 117
xref: PTHR10539:SF0
organism: Homo sapiens

PTHR10855:SF1
type: RelationshipXref
id: PTHR10855:SF1
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7739 24
type: UnificationXref
id: 7739
db: ncbitaxon

G1/S-specific cyclin-D3 isoform 2
type: ProteinReference
xref: PTHR10177:SF65
xref: uniprot F7GU42 135
organism: Macaca mulatta

uniprot Q2KJ46 91
type: UnificationXref
id: Q2KJ46
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot F7BEI4 125
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r39 199
type: Stoichiometry
physical entity: Cyclin B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r39 198
type: Stoichiometry
physical entity: Complex (Protein kinase subunit/Cyclin B)
stoichiometric coefficient: 1.0

uniprot A0A452DIV3 133
type: UnificationXref
id: A0A452DIV3
db: uniprot

CINP isoform 7
type: ProteinReference
xref: uniprot A0A2I3RPW4 147
xref: PTHR15827:SF2
organism: Pan troglodytes

Complex (Rb/E2F)
type: Complex
component stoichiometry: E2F s7 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rb s6 sa5 STOICHIOMETRY ID COMPLEX
component: E2F
component: Rb
feature: COMPLEX BINDING FEATURE s8 a12 179
feature: COMPLEX BINDING FEATURE s8 a12 177
cellular location: Mid G sub 1 endsub c6

Anaphase c11
type: CellularLocationVocabulary
comment: Anaphase

Cyclin D1
type: ProteinReference
xref: uniprot A0A452DIV3 133
xref: PTHR10177:SF67
organism: Bos taurus

HETERODIMER_ASSOCIATION_LEFT__E2F-_Rb-RIGHT__Complex__Rb_E2F_-_r24
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 193
left: Rb
left: E2F
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Rb/E2F)

uniprot F6Q7B1 158
type: UnificationXref
id: F6Q7B1
db: uniprot

eco ECO:0000316 77
type: UnificationXref
id: ECO:0000316
db: eco

Rb
type: Protein
feature: Rb s6 sa5 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 178
cellular location: Mid G sub 1 endsub c6
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 185431 93
type: UnificationXref
id: 185431
db: ncbitaxon

Mitosis c5
type: CellularLocationVocabulary
comment: Mitosis

uniprot P14685 72
type: UnificationXref
id: P14685
db: uniprot

uniprot F6UG68 39
type: UnificationXref
id: F6UG68
db: uniprot

Proteasome 26S subunit, non-ATPase 4
type: ProteinReference
xref: uniprot F1PRW0 34
xref: PTHR10223:SF0
organism: Canis lupus familiaris

PTHR10410:SF27
type: RelationshipXref
id: PTHR10410:SF27
db: PANTHER Family
relationship type: By Homology

Cyclin B
type: Protein
entity reference: Cyclin B
feature: Cyclin B s77 a102 rs1
cellular location: Mitosis c5
comment: SPECIES_TYPE=PROTEIN

Bos taurus
type: BioSource
xref: ncbitaxon 9913 19

UNKNOWN_TRANSITION
type: InteractionVocabulary

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 3

00696
type: UnificationXref
id: MOD:00696
db: mod

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 44

Proteasome 26S subunit, non-ATPase 13
type: ProteinReference
xref: PTHR10539:SF0
xref: uniprot A0A2I3S463 15
organism: Pan troglodytes

uniprot F6UPJ2 40
type: UnificationXref
id: F6UPJ2
db: uniprot

eco ECO:0000353 127
type: UnificationXref
id: ECO:0000353
db: eco

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 82

uniprot Q586L6 102
type: UnificationXref
id: Q586L6
db: uniprot

uniprot P25322 138
type: UnificationXref
id: P25322
db: uniprot

Cyclin-dependent kinase 2-interacting protein
type: ProteinReference
xref: uniprot B0BNM8 148
xref: PTHR15827:SF2
organism: Rattus norvegicus

uniprot O42897 65
type: UnificationXref
id: O42897
db: uniprot

APC s28 a46 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Cdk2 s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cdk2
stoichiometric coefficient: 1.0

Cdk2
type: Protein
entity reference: Cdk2
cellular location: Late G sub 1 endsub c7
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 10090 63
type: UnificationXref
id: 10090
db: ncbitaxon

Cyclin B
type: ProteinReference
xref: P00486
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cell cycle.PROTEIN.GENERIC.Cyclin B
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclin B Synonym: Synonym not specified Accession: P00486
member entity reference: G2/mitotic-specific cyclin-B
member entity reference: Cyclin B1

PTHR10678:SF6
type: RelationshipXref
id: PTHR10678:SF6
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: RelationshipTypeVocabulary

PTHR10678:SF4
type: RelationshipXref
id: PTHR10678:SF4
db: PANTHER Family
relationship type: By Homology

26S proteasome regulatory complex subunit p39A
type: ProteinReference
xref: uniprot Q7KMP8 109
xref: PTHR10539:SF0
organism: Drosophila melanogaster

PTHR10678:SF2
type: RelationshipXref
id: PTHR10678:SF2
db: PANTHER Family
relationship type: By Homology

Cyclin B s12 sa10 rs1
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P30281 140
type: UnificationXref
id: P30281
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 29

Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12
type: ProteinReference
xref: uniprot Q5XIC6 106
xref: PTHR10855:SF1
organism: Rattus norvegicus

Cyclin B s10 sa8 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot C3XXY6 23
type: UnificationXref
id: C3XXY6
db: uniprot

Proteasome regulatory non-ATP-ase subunit 5
type: ProteinReference
xref: uniprot Q38C86 97
xref: PTHR10855:SF1
organism: Trypanosoma brucei

26S proteasome non-ATPase regulatory subunit 11
type: ProteinReference
xref: PTHR10678:SF2
xref: uniprot Q1K564 87
organism: Neurospora crassa

uniprot P30282 142
type: UnificationXref
id: P30282
db: uniprot

PTHR10540:SF12
type: RelationshipXref
id: PTHR10540:SF12
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r3 195
type: Stoichiometry
physical entity: E2F
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 194
type: Stoichiometry
physical entity: E2F
stoichiometric coefficient: 1.0

26S proteasome non-ATPase regulatory subunit 14 homolog
type: ProteinReference
xref: PTHR10410:SF27
xref: uniprot Q9LT08 113
organism: Arabidopsis thaliana

uniprot O88321 70
type: UnificationXref
id: O88321
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 27

Proteasome regulatory non-ATP-ase subunit 3
type: ProteinReference
xref: uniprot Q386U6 92
xref: PTHR10758:SF2
organism: Trypanosoma brucei

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__E2F-RIGHT__E2F-_r3
controller: E2F

Proteasome regulatory non-ATPase subunit 6
type: ProteinReference
xref: PTHR10678:SF2
xref: uniprot Q586L6 102
organism: Trypanosoma brucei

uniprot P55035 79
type: UnificationXref
id: P55035
db: uniprot

ncbitaxon 44689 153
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot O17869 162
type: UnificationXref
id: O17869
db: uniprot

uniprot F1PRW0 34
type: UnificationXref
id: F1PRW0
db: uniprot

Transcription factor E2f1
type: ProteinReference
xref: uniprot Q27368 156
xref: PTHR12081:SF18
organism: Drosophila melanogaster

uniprot W4XEA0 131
type: UnificationXref
id: W4XEA0
db: uniprot

Rb
type: Protein
feature: ACTIVE 10
feature: Rb s53 a78 rs1
cellular location: Late G sub 1 endsub c7
comment: SPECIES_TYPE=PROTEIN

uniprot O74440 69
type: UnificationXref
id: O74440
db: uniprot

PARTICIPANT STOICHIOMETRY r23 197
type: Stoichiometry
physical entity: Pre-replication Complex
stoichiometric coefficient: 1.0

Rb
type: Protein
feature: Rb s51 a76 rs1
cellular location: Mid G sub 1 endsub c6
comment: SPECIES_TYPE=PROTEIN

G1/S-specific cyclin-D1
type: ProteinReference
xref: uniprot P39948 143
xref: PTHR10177:SF67
organism: Rattus norvegicus

STATE_TRANSITION
type: RelationshipTypeVocabulary

G1/S-specific cyclin-E1
type: ProteinReference
xref: PTHR10177:SF71
xref: uniprot P39949 128
organism: Rattus norvegicus

PSMD11 isoform 1
type: ProteinReference
xref: PTHR10678:SF2
xref: uniprot H2QCM9 53
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot E1C6N0 26
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r23 196
type: Stoichiometry
physical entity: Pre-replication Complex
stoichiometric coefficient: 1.0

Protein kinase subunit
type: Protein
entity reference: Protein kinase subunit
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa9 174
cellular location: Anaphase c11
comment: SPECIES_TYPE=PROTEIN

Pre-replication Complex
type: Protein
entity reference: Pre-replication Complex
cellular location: S Phase c12
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Pre_replication_Complex-RIGHT__Pre_replication_Complex-_r23
controller: CdkC

PSMD7 isoform 1
type: ProteinReference
xref: uniprot H2QBI1 52
xref: PTHR10540:SF12
organism: Pan troglodytes

ncbitaxon 9258 44
type: UnificationXref
id: 9258
db: ncbitaxon

CCND2 isoform 1
type: ProteinReference
xref: PTHR10177:SF66
xref: uniprot H2Q584 136
organism: Pan troglodytes

ncbitaxon 3702 60
type: UnificationXref
id: 3702
db: ncbitaxon

26S proteasome non-ATPase regulatory subunit 7
type: ProteinReference
xref: uniprot F6TS39 38
xref: PTHR10540:SF7
organism: Macaca mulatta

26S proteasome non-ATPase regulatory subunit 4
type: ProteinReference
xref: PTHR10223:SF0
xref: uniprot O35226 62
organism: Mus musculus

Proteasome regulatory non-ATPase subunit 11
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot Q38BU2 96
organism: Trypanosoma brucei

Antisecretory factor
type: ProteinReference
xref: PTHR10223:SF0
xref: uniprot O88321 70
organism: Rattus norvegicus

Cdk4 6 s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cdk4/6
stoichiometric coefficient: 1.0

ncbitaxon 367110 88
type: UnificationXref
id: 367110
db: ncbitaxon

G1/S-specific cyclin-E
type: ProteinReference
xref: uniprot O01501 160
organism: Caenorhabditis elegans

CCNE2 isoform 1
type: ProteinReference
xref: uniprot H2R9R9 159
organism: Pan troglodytes

uniprot O01501 160
type: UnificationXref
id: O01501
db: uniprot

PARTICIPANT STOICHIOMETRY r26 186
type: Stoichiometry
physical entity: Cyclin E
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 185
type: Stoichiometry
physical entity: Cdk2
stoichiometric coefficient: 1.0

uniprot H2QU67 6
type: UnificationXref
id: H2QU67
db: uniprot

DISSOCIATION_LEFT__Complex__Protein_kinase_subunit_Cyclin_B_-RIGHT__Cyclin_B-_Protein_kinase_subunit-_r38
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 202
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 200
left: Complex (Protein kinase subunit/Cyclin B)
interaction type: DISSOCIATION
right: Protein kinase subunit
right: Cyclin B

PARTICIPANT STOICHIOMETRY r26 187
type: Stoichiometry
physical entity: Complex (Cyclin E/Cdk2)
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__APC_-_ATP-RIGHT__APC_-_ADP-_r29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 212
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 209
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 211
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 210
left: APC
left: ATP
interaction type: STATE_TRANSITION
right: APC
right: ADP

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 161

uniprot Q9WVJ2 119
type: UnificationXref
id: Q9WVJ2
db: uniprot

ncbitaxon 36329 12
type: UnificationXref
id: 36329
db: ncbitaxon

Protein kinase A regulatory subunit
type: ProteinReference
xref: uniprot Q385V6 122
xref: PTHR11635:SF152
organism: Trypanosoma brucei

HETERODIMER_ASSOCIATION_LEFT__Protein_kinase_subunit-_Cyclin_B-RIGHT__Complex__Protein_kinase_subunit_Cyclin_B_-_r28
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 214
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 213
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 215
left: Protein kinase subunit
left: Cyclin B
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Protein kinase subunit/Cyclin B)

PTHR12081:SF18
type: RelationshipXref
id: PTHR12081:SF18
db: PANTHER Family
relationship type: By Homology

uniprot F1QGH9 35
type: UnificationXref
id: F1QGH9
db: uniprot

uniprot Q57YH3 101
type: UnificationXref
id: Q57YH3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q7U3 146
xref: PTHR15827:SF2
organism: Macaca mulatta

CdkC
type: ProteinReference
xref: P00489
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: CdkC Synonym: Synonym not specified Accession: P00489
comment: ENTITY_REFERENCE_ID_DESC=Cell cycle.PROTEIN.GENERIC.CdkC
member entity reference: G1/S-specific cyclin-E2
member entity reference: CyCliN K
member entity reference: CCNE1 isoform 1
member entity reference: Cyclin E2
member entity reference: CCNE2 isoform 1
member entity reference: G1/S-specific cyclin-E1
member entity reference: G1/S-specific cyclin-E
member entity reference: Uncharacterized protein

26S proteasome regulatory subunit rpn8
type: ProteinReference
xref: uniprot O74440 69
xref: PTHR10540:SF7
organism: Schizosaccharomyces pombe

Uncharacterized protein
type: ProteinReference
xref: PTHR10177:SF344
xref: uniprot W4XEA0 131
organism: Strongylocentrotus purpuratus

uniprot F6P3G4 37
type: UnificationXref
id: F6P3G4
db: uniprot

uniprot P35244 8
type: UnificationXref
id: P35244
db: uniprot

DISSOCIATION_LEFT__Complex__Rb_E2F_-RIGHT__E2F-_Rb-_r25
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 188
left: Complex (Rb/E2F)
interaction type: DISSOCIATION
right: E2F
right: Rb

Cyclin-dependent kinase 2-interacting protein
type: ProteinReference
xref: PTHR15827:SF2
xref: uniprot Q9BW66 149
organism: Homo sapiens

uniprot A0A3Q1N077 18
type: UnificationXref
id: A0A3Q1N077
db: uniprot

CyCliN K
type: ProteinReference
xref: uniprot O17869 162
organism: Caenorhabditis elegans

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 108

26S proteasome non-ATPase regulatory subunit 7
type: ProteinReference
xref: uniprot P26516 74
xref: PTHR10540:SF7
organism: Mus musculus

uniprot H2QCM9 53
type: UnificationXref
id: H2QCM9
db: uniprot

Proteasome activator subunit 3
type: ProteinReference
xref: PTHR10660:SF4
xref: uniprot E2RPY9 32
organism: Canis lupus familiaris

uniprot F7CHT9 45
type: UnificationXref
id: F7CHT9
db: uniprot

CCND3 isoform 1
type: ProteinReference
xref: uniprot A0A2I3RXN8 132
xref: PTHR10177:SF65
organism: Pan troglodytes

UNKNOWN_TRANSITION
type: RelationshipTypeVocabulary

Cyclin E s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cyclin E
stoichiometric coefficient: 1.0

Telophase c8
type: CellularLocationVocabulary
comment: Telophase

Proteasome regulatory non-ATP-ase subunit 10
type: ProteinReference
xref: PTHR10223:SF0
xref: uniprot Q57YH3 101
organism: Trypanosoma brucei

uniprot B0BNM8 148
type: UnificationXref
id: B0BNM8
db: uniprot

Proteasome regulatory non-ATP-ase subunit 9
type: ProteinReference
xref: uniprot Q387U2 94
xref: PTHR10539:SF0
organism: Trypanosoma brucei

G1/S-specific cyclin-E1
type: ProteinReference
xref: uniprot Q61457 130
xref: PTHR10177:SF71
organism: Mus musculus

Cdk4/6
type: Protein
entity reference: Cdk4/6
cellular location: Mid G sub 1 endsub c6
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Cyclin_B-RIGHT__a102_degraded-_r35
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 205
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 206
left: Cyclin B
interaction type: STATE_TRANSITION
right: a102_degraded

26S proteasome non-ATPase regulatory subunit 14
type: ProteinReference
xref: uniprot O00487 58
xref: PTHR10410:SF5
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r31 208
type: Stoichiometry
physical entity: Complex (Protein kinase subunit/Cyclin B)
stoichiometric coefficient: 1.0

uniprot Q17QP9 86
type: UnificationXref
id: Q17QP9
db: uniprot

Mid G sub 1 endsub c6
type: CellularLocationVocabulary
comment: Mid G_sub_1_endsub_

26S proteasome regulatory subunit rpn-8
type: ProteinReference
xref: uniprot Q8WZY4 111
xref: PTHR10540:SF7
organism: Neurospora crassa

PARTICIPANT STOICHIOMETRY r31 207
type: Stoichiometry
physical entity: Complex (Protein kinase subunit/Cyclin B)
stoichiometric coefficient: 1.0

uniprot P40016 75
type: UnificationXref
id: P40016
db: uniprot

uniprot J9JHD9 55
type: UnificationXref
id: J9JHD9
db: uniprot

PSMD14 isoform 1
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot H2QIW0 54
organism: Pan troglodytes

uniprot Q9UNM6 117
type: UnificationXref
id: Q9UNM6
db: uniprot

Complex (Protein kinase subunit/Cyclin B)
type: Complex
component stoichiometry: Cyclin B s12 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Protein kinase subunit s11 sa9 STOICHIOMETRY ID COMPLEX
component: Cyclin B
component: Protein kinase subunit
feature: COMPLEX BINDING FEATURE s74 a98 173
feature: COMPLEX BINDING FEATURE s74 a98 175
cellular location: Anaphase c11

Proteasome activator subunit 3
type: ProteinReference
xref: PTHR10660:SF4
xref: uniprot A0A3Q1N077 18
organism: Bos taurus

STATE_TRANSITION_LEFT__E2F-RIGHT__E2F-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 195
left: E2F
interaction type: STATE_TRANSITION
right: E2F

uniprot A0A2I3S463 15
type: UnificationXref
id: A0A2I3S463
db: uniprot

26S proteasome non-ATPase regulatory subunit 3
type: ProteinReference
xref: uniprot G2HF36 51
xref: PTHR10758:SF2
organism: Pan troglodytes

PTHR10177:SF193
type: RelationshipXref
id: PTHR10177:SF193
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Pre_replication_Complex-RIGHT__Pre_replication_Complex-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 197
left: Pre-replication Complex
interaction type: STATE_TRANSITION
right: Pre-replication Complex

uniprot A0A2I3SRL8 16
type: UnificationXref
id: A0A2I3SRL8
db: uniprot

ncbitaxon 9606 9
type: UnificationXref
id: 9606
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r29 210
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Protein kinase subunit s11 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Protein kinase subunit
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r29 211
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r29 212
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 24

uniprot A0A1D5Q7U3 146
type: UnificationXref
id: A0A1D5Q7U3
db: uniprot

PARTICIPANT STOICHIOMETRY r27 216
type: Stoichiometry
physical entity: Cyclin D
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r27 217
type: Stoichiometry
physical entity: Cdk4/6
stoichiometric coefficient: 1.0

uniprot F7DST4 48
type: UnificationXref
id: F7DST4
db: uniprot

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

PARTICIPANT STOICHIOMETRY r27 218
type: Stoichiometry
physical entity: Complex (Cdk4/6/ Cyclin D)
stoichiometric coefficient: 1.0

Probable 26S proteasome regulatory subunit rpn3
type: ProteinReference
xref: PTHR10758:SF2
xref: uniprot O42897 65
organism: Schizosaccharomyces pombe

Cdk4/6
type: Protein
entity reference: Cdk4/6
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 166
cellular location: Mid G sub 1 endsub c6
comment: SPECIES_TYPE=PROTEIN

uniprot Q4V8E2 100
type: UnificationXref
id: Q4V8E2
db: uniprot

IDA
type: EvidenceCodeVocabulary

uniprot O00231 56
type: UnificationXref
id: O00231
db: uniprot

uniprot P20439 151
type: UnificationXref
id: P20439
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 127

G1/S-specific cyclin-D1
type: ProteinReference
xref: PTHR10177:SF67
xref: uniprot H9FY18 137
organism: Macaca mulatta

G1/S-specific cyclin-D2
type: ProteinReference
xref: PTHR10177:SF66
xref: uniprot Q0P5D3 144
organism: Bos taurus

UNKNOWN_TRANSITION_LEFT__Complex__Protein_kinase_subunit_Cyclin_B_-RIGHT__Cyclin_B-_r39
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: UNKNOWN TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 198
left: Complex (Protein kinase subunit/Cyclin B)
interaction type: UNKNOWN_TRANSITION
right: Cyclin B

Cdk4/6
type: ProteinReference
xref: P00479
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cell cycle.PROTEIN.GENERIC.Cdk4/6
comment: ENTITY_REFERENCE_NOTES=Long Name: Cdk4/6 Synonym: Synonym not specified Accession: P00479
member entity reference: Protein kinase 6

Rb s51 a76 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Proteasome activator subunit 2
type: ProteinReference
xref: uniprot Q9PUC4 115
xref: PTHR10660:SF6
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r25 189
type: Stoichiometry
physical entity: E2F
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 188
type: Stoichiometry
physical entity: Complex (Rb/E2F)
stoichiometric coefficient: 1.0

Cyclin D s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cyclin D
stoichiometric coefficient: 1.0

Cyclin B s66 a91 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q385V6 122
type: UnificationXref
id: Q385V6
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 46

26S proteasome non-ATPase regulatory subunit 13
type: ProteinReference
xref: uniprot B0BN93 21
xref: PTHR10539:SF0
organism: Rattus norvegicus

Probable 26S proteasome regulatory subunit rpn9
type: ProteinReference
xref: uniprot Q9US13 118
xref: PTHR10539:SF0
organism: Schizosaccharomyces pombe

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

26S proteasome non-ATPase regulatory subunit 14
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot O35593 64
organism: Mus musculus

PTHR10177:SF344
type: RelationshipXref
id: PTHR10177:SF344
db: PANTHER Family
relationship type: By Homology

PTHR10177:SF347
type: RelationshipXref
id: PTHR10177:SF347
db: PANTHER Family
relationship type: By Homology

uniprot Q7ZU21 154
type: UnificationXref
id: Q7ZU21
db: uniprot

PARTICIPANT STOICHIOMETRY r25 190
type: Stoichiometry
physical entity: Rb
stoichiometric coefficient: 1.0

uniprot P26516 74
type: UnificationXref
id: P26516
db: uniprot

Replication protein A 14 kDa subunit
type: ProteinReference
xref: uniprot F6TGA8 2
xref: PTHR15114:SF1
organism: Macaca mulatta

26S proteasome regulatory subunit RPN6
type: ProteinReference
xref: PTHR10678:SF2
xref: uniprot Q12377 85
organism: Saccharomyces cerevisiae

ncbitaxon 39947 108
type: UnificationXref
id: 39947
db: ncbitaxon

19S proteasome regulatory subunit
type: ProteinReference
xref: uniprot Q4QCD7 98
xref: PTHR10855:SF1
organism: Leishmania major

Cyclin B
type: Protein
entity reference: Cyclin B
feature: Cyclin B s12 sa10 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa10 176
cellular location: Anaphase c11
comment: SPECIES_TYPE=PROTEIN

uniprot F7CV41 47
type: UnificationXref
id: F7CV41
db: uniprot

P00482
type: UnificationXref
id: P00482
db: PANTHER Pathway Component

E2F
type: Protein
entity reference: E2F
cellular location: Mid G sub 1 endsub c6
comment: SPECIES_TYPE=PROTEIN

P00483
type: UnificationXref
id: P00483
db: PANTHER Pathway Component

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 66

P00480
type: UnificationXref
id: P00480
db: PANTHER Pathway Component

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 141

P00486
type: UnificationXref
id: P00486
db: PANTHER Pathway Component

PTHR15114:SF1
type: RelationshipXref
id: PTHR15114:SF1
db: PANTHER Family
relationship type: By Homology

P00484
type: UnificationXref
id: P00484
db: PANTHER Pathway Component

P00485
type: UnificationXref
id: P00485
db: PANTHER Pathway Component

G2/mitotic-specific cyclin-B
type: ProteinReference
xref: uniprot P20439 151
xref: PTHR10177:SF347
organism: Drosophila melanogaster

uniprot Q38BU2 96
type: UnificationXref
id: Q38BU2
db: uniprot

uniprot G2HF36 51
type: UnificationXref
id: G2HF36
db: uniprot

Cyclin E
type: Protein
entity reference: Cyclin E
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 182
cellular location: Late G sub 1 endsub c7
comment: SPECIES_TYPE=PROTEIN

uniprot Q9US13 118
type: UnificationXref
id: Q9US13
db: uniprot

P00479
type: UnificationXref
id: P00479
db: PANTHER Pathway Component

a102_degraded
type: PhysicalEntity
cellular location: Mitosis c5
comment: SPECIES_TYPE=DEGRADED

P00478
type: UnificationXref
id: P00478
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Cyclin_B-RIGHT__a102_degraded-_r35
controller: Proteasome

DISSOCIATION
type: InteractionVocabulary

Cyclin B
type: Protein
entity reference: Cyclin B
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa8 172
feature: Cyclin B s10 sa8 rs1
cellular location: Metaphase c10
comment: SPECIES_TYPE=PROTEIN

uniprot Q9PUC4 115
type: UnificationXref
id: Q9PUC4
db: uniprot

ncbitaxon 9615 29
type: UnificationXref
id: 9615
db: ncbitaxon

PTHR10539:SF0
type: RelationshipXref
id: PTHR10539:SF0
db: PANTHER Family
relationship type: By Homology

26S proteasome regulatory subunit RPN3
type: ProteinReference
xref: PTHR10758:SF2
xref: uniprot P40016 75
organism: Saccharomyces cerevisiae

uniprot Q9D8W5 112
type: UnificationXref
id: Q9D8W5
db: uniprot

PARTICIPANT STOICHIOMETRY r36 203
type: Stoichiometry
physical entity: Cyclin B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r36 204
type: Stoichiometry
physical entity: Cyclin B
stoichiometric coefficient: 1.0

Cyclin B
type: Protein
entity reference: Cyclin B
feature: Cyclin B s79 a104 rs1
cellular location: Telophase c8
comment: SPECIES_TYPE=PROTEIN

uniprot F1NPQ0 33
type: UnificationXref
id: F1NPQ0
db: uniprot

Proteasome 26S subunit, non-ATPase 3
type: ProteinReference
xref: uniprot E2QUY7 28
xref: PTHR10758:SF2
organism: Canis lupus familiaris

26S proteasome non-ATPase regulatory subunit 11
type: ProteinReference
xref: PTHR10678:SF2
xref: uniprot Q8BG32 110
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r35 205
type: Stoichiometry
physical entity: Cyclin B
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 206
type: Stoichiometry
physical entity: a102_degraded
stoichiometric coefficient: 1.0

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 9

Cyclin E
type: ProteinReference
xref: P00483
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cell cycle.PROTEIN.GENERIC.Cyclin E
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclin E Synonym: Synonym not specified Accession: P00483
member entity reference: CCNE1 isoform 1
member entity reference: G1/S-specific cyclin-E1
member entity reference: Uncharacterized protein

Proteasome 26S subunit, non-ATPase 14
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot F7AZ85 43
organism: Ornithorhynchus anatinus

uniprot O35593 64
type: UnificationXref
id: O35593
db: uniprot

Complex (Cdk4/6/ Cyclin D)
type: Complex
component stoichiometry: Cdk4 6 s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cyclin D s2 sa2 STOICHIOMETRY ID COMPLEX
component: Cdk4/6
component: Cyclin D
feature: ACTIVE 10
feature: COMPLEX BINDING FEATURE s4 a6 167
feature: COMPLEX BINDING FEATURE s4 a6 165
cellular location: Mid G sub 1 endsub c6

26S proteasome non-ATPase regulatory subunit 11
type: ProteinReference
xref: PTHR10678:SF2
xref: uniprot Q2KI42 89
organism: Bos taurus

PTHR11635:SF152
type: RelationshipXref
id: PTHR11635:SF152
db: PANTHER Family
relationship type: By Homology

Cyclin B s79 a104 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r29 209
type: Stoichiometry
physical entity: APC
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot F7HMX1 50
organism: Macaca mulatta

uniprot Q5E964 103
type: UnificationXref
id: Q5E964
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 60

uniprot H2QBI1 52
type: UnificationXref
id: H2QBI1
db: uniprot

Cyclin D; Uncharacterized protein
type: ProteinReference
xref: PTHR10177:SF203
xref: uniprot Q964G0 145
organism: Strongylocentrotus purpuratus

PARTICIPANT STOICHIOMETRY r38 201
type: Stoichiometry
physical entity: Cyclin B
stoichiometric coefficient: 1.0

G1/S-specific cyclin-D3
type: ProteinReference
xref: PTHR10177:SF65
xref: uniprot F1MV86 134
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r38 202
type: Stoichiometry
physical entity: Protein kinase subunit
stoichiometric coefficient: 1.0

Rb s6 sa5 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r38 200
type: Stoichiometry
physical entity: Complex (Protein kinase subunit/Cyclin B)
stoichiometric coefficient: 1.0

uniprot P51665 78
type: UnificationXref
id: P51665
db: uniprot

eco ECO:0000304 73
type: UnificationXref
id: ECO:0000304
db: eco

uniprot O35226 62
type: UnificationXref
id: O35226
db: uniprot

Cyclin B1
type: ProteinReference
xref: PTHR10177:SF193
xref: uniprot Q7ZU21 154
organism: Danio rerio

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 121

Cyclin D
type: ProteinReference
xref: P00484
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cell cycle.PROTEIN.GENERIC.Cyclin D
comment: ENTITY_REFERENCE_NOTES=Long Name: Cyclin D Synonym: Synonym not specified Accession: P00484
member entity reference: G1/S-specific cyclin-D3
member entity reference: Cyclin D; Uncharacterized protein
member entity reference: G1/S-specific cyclin-D2
member entity reference: CCND2 isoform 1
member entity reference: G1/S-specific cyclin-D3 isoform 2
member entity reference: G1/S-specific cyclin-D1
member entity reference: CCND3 isoform 1
member entity reference: Cyclin D1

uniprot F7FUB1 49
type: UnificationXref
id: F7FUB1
db: uniprot

Rb s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rb
stoichiometric coefficient: 1.0

Proteasome
type: ProteinReference
xref: P00480
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Proteasome Synonym: Synonym not specified Accession: P00480
comment: ENTITY_REFERENCE_ID_DESC=Cell cycle.PROTEIN.GENERIC.Proteasome
member entity reference: Proteasome activator complex subunit 3
member entity reference: Uncharacterized protein
member entity reference: Proteasome 26S subunit, non-ATPase 3
member entity reference: 26S proteasome non-ATPase regulatory subunit 14
member entity reference: 26S proteasome non-ATPase regulatory subunit 11
member entity reference: Antisecretory factor
member entity reference: Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12
member entity reference: Proteasome regulatory non-ATPase subunit 8
member entity reference: Proteasome 26S subunit, non-ATPase 12
member entity reference: 26S proteasome non-ATPase regulatory subunit 4
member entity reference: PSME3 isoform 5
member entity reference: Proteasome 26S subunit, non-ATPase 14
member entity reference: Proteasome 26S subunit, non-ATPase 4
member entity reference: 26S proteasome non-ATPase regulatory subunit 13
member entity reference: 26S proteasome non-ATPase regulatory subunit 12 isoform 1
member entity reference: 19S proteasome regulatory subunit
member entity reference: 26S proteasome regulatory subunit rpn-8
member entity reference: Proteasome regulatory non-ATP-ase subunit 9
member entity reference: PSMD14 isoform 1
member entity reference: Probable 26S proteasome regulatory subunit rpn9
member entity reference: Proteasome regulatory non-ATPase subunit 6
member entity reference: 26S proteasome non-ATPase regulatory subunit 7
member entity reference: Proteasome regulatory non-ATPase subunit 11
member entity reference: Proteasome activator subunit 2
member entity reference: Proteasome 26S subunit, non-ATPase 11
member entity reference: 26S proteasome non-ATPase regulatory subunit 3
member entity reference: 26S proteasome regulatory complex subunit p39A
member entity reference: 26S proteasome non-ATPase regulatory subunit 11A
member entity reference: 26S proteasome regulatory subunit RPN3
member entity reference: 26S proteasome non-ATPase regulatory subunit 12
member entity reference: Proteasome activator subunit 3
member entity reference: Os05g0371200 protein
member entity reference: Proteasome regulatory non-ATP-ase subunit 10
member entity reference: 26S proteasome regulatory subunit rpn8
member entity reference: Proteasome 26S subunit, non-ATPase 13
member entity reference: Proteasome regulatory non-ATP-ase subunit 5
member entity reference: Probable 26S proteasome regulatory subunit rpn3
member entity reference: Eukaryotic translation initiation factor 3 subunit F
member entity reference: Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14
member entity reference: 26S proteasome regulatory subunit rpn10
member entity reference: Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3
member entity reference: 26S proteasome non-ATPase regulatory subunit 7 homolog A
member entity reference: 26S proteasome non-ATPase regulatory subunit 11B
member entity reference: Proteasome regulatory non-ATP-ase subunit 3
member entity reference: Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Predicted)

uniprot F7AZ85 43
type: UnificationXref
id: F7AZ85
db: uniprot

uniprot E2RJ26 31
type: UnificationXref
id: E2RJ26
db: uniprot

Cyclin B s10 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cyclin B
stoichiometric coefficient: 1.0

ncbitaxon 9544 3
type: UnificationXref
id: 9544
db: ncbitaxon

ADP
type: SmallMolecule
cellular location: Mitosis c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

26S proteasome non-ATPase regulatory subunit 13
type: ProteinReference
xref: PTHR10539:SF0
xref: uniprot Q5E964 103
organism: Bos taurus

Danio rerio
type: BioSource
xref: ncbitaxon 7955 36

E2F transcription factor 3
type: ProteinReference
xref: PTHR12081:SF44
xref: uniprot F6VW96 155
organism: Xenopus tropicalis

Cyclin B
type: Protein
entity reference: Cyclin B
feature: Cyclin B s66 a91 rs1
cellular location: Interphase br Prophase c9
comment: SPECIES_TYPE=PROTEIN

PANTHER Pathway P00013 1
type: UnificationXref
id: P00013
db: PANTHER Pathway

P00489
type: UnificationXref
id: P00489
db: PANTHER Pathway Component

P00488
type: UnificationXref
id: P00488
db: PANTHER Pathway Component

Rb s53 a78 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

26S proteasome non-ATPase regulatory subunit 7
type: ProteinReference
xref: uniprot P51665 78
xref: PTHR10540:SF12
organism: Homo sapiens

Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot Q4V8E2 100
organism: Rattus norvegicus

uniprot F7BEI4 125
type: UnificationXref
id: F7BEI4
db: uniprot

uniprot Q8BG32 110
type: UnificationXref
id: Q8BG32
db: uniprot

PTHR10223:SF0
type: RelationshipXref
id: PTHR10223:SF0
db: PANTHER Family
relationship type: By Homology

Proteasome activator complex subunit 3
type: ProteinReference
xref: uniprot Q5F3J5 104
xref: PTHR10660:SF4
organism: Gallus gallus

Complex (Cyclin E/Cdk2)
type: Complex
component stoichiometry: Cdk2 s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cyclin E s3 sa3 STOICHIOMETRY ID COMPLEX
component: Cdk2
component: Cyclin E
feature: COMPLEX BINDING FEATURE s16 a30 181
feature: ACTIVE 10
feature: COMPLEX BINDING FEATURE s16 a30 183
cellular location: Late G sub 1 endsub c7

Eukaryotic translation initiation factor 3 subunit F
type: ProteinReference
xref: uniprot O43060 67
xref: PTHR10540:SF6
organism: Schizosaccharomyces pombe

uniprot A0A452DI44 20
type: UnificationXref
id: A0A452DI44
db: uniprot

uniprot W4YTT9 120
type: UnificationXref
id: W4YTT9
db: uniprot

PTHR10223:SF7
type: RelationshipXref
id: PTHR10223:SF7
db: PANTHER Family
relationship type: By Homology

Interphase br Prophase c9
type: CellularLocationVocabulary
comment: Interphase_br_Prophase

Proteasome 26S subunit, non-ATPase 13
type: ProteinReference
xref: uniprot E2R5N5 30
xref: PTHR10539:SF0
organism: Canis lupus familiaris

26S proteasome non-ATPase regulatory subunit 4
type: ProteinReference
xref: uniprot P55036 81
xref: PTHR10223:SF7
organism: Homo sapiens

uniprot E2R5N5 30
type: UnificationXref
id: E2R5N5
db: uniprot

PARTICIPANT STOICHIOMETRY r24 192
type: Stoichiometry
physical entity: Rb
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 193
type: Stoichiometry
physical entity: Complex (Rb/E2F)
stoichiometric coefficient: 1.0

Cdk2
type: Protein
entity reference: Cdk2
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 184
cellular location: Late G sub 1 endsub c7
comment: SPECIES_TYPE=PROTEIN

26S proteasome non-ATPase regulatory subunit 4
type: ProteinReference
xref: uniprot P55035 79
xref: PTHR10223:SF0
organism: Drosophila melanogaster

26S proteasome non-ATPase regulatory subunit 12
type: ProteinReference
xref: uniprot Q2KJ25 90
xref: PTHR10855:SF1
organism: Bos taurus

Pre-replication Complex
type: Protein
entity reference: Pre-replication Complex
feature: ACTIVE 10
cellular location: S Phase c12
comment: SPECIES_TYPE=PROTEIN

E2F
type: Protein
entity reference: E2F
feature: ACTIVE 10
cellular location: Late G sub 1 endsub c7
comment: SPECIES_TYPE=PROTEIN

By Homology
type: RelationshipTypeVocabulary

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 153

E2F
type: Protein
entity reference: E2F
cellular location: Late G sub 1 endsub c7
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Os05g0371200 protein
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot Q60EW3 107
organism: Oryza sativa

Uncharacterized protein
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot F7CHT9 45
organism: Monodelphis domestica

uniprot Q9BW66 149
type: UnificationXref
id: Q9BW66
db: uniprot

E2F
type: Protein
entity reference: E2F
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa6 180
cellular location: Mid G sub 1 endsub c6
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UG68 39
xref: PTHR10758:SF2
organism: Macaca mulatta

uniprot Q5U2S7 105
type: UnificationXref
id: Q5U2S7
db: uniprot

eco ECO:0000501 82
type: UnificationXref
id: ECO:0000501
db: eco

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__Rb_E2F_-RIGHT__E2F-_Rb-_r25
controller: Complex (Cyclin E/Cdk2)

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 61

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 93

uniprot E1C6N0 26
type: UnificationXref
id: E1C6N0
db: uniprot

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 73

Protein kinase subunit
type: Protein
entity reference: Protein kinase subunit
cellular location: Mitosis c5
comment: SPECIES_TYPE=PROTEIN

uniprot P61290 84
type: UnificationXref
id: P61290
db: uniprot

26S proteasome non-ATPase regulatory subunit 12
type: ProteinReference
xref: uniprot O00232 57
xref: PTHR10855:SF1
organism: Homo sapiens

26S proteasome non-ATPase regulatory subunit 11
type: ProteinReference
xref: PTHR10678:SF2
xref: uniprot O00231 56
organism: Homo sapiens

PTHR10177:SF66
type: RelationshipXref
id: PTHR10177:SF66
db: PANTHER Family
relationship type: By Homology

eco ECO:0000303 61
type: UnificationXref
id: ECO:0000303
db: eco

PTHR10177:SF65
type: RelationshipXref
id: PTHR10177:SF65
db: PANTHER Family
relationship type: By Homology

Protein kinase subunit
type: Protein
entity reference: Protein kinase subunit
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa7 170
cellular location: Metaphase c10
comment: SPECIES_TYPE=PROTEIN

PTHR10177:SF67
type: RelationshipXref
id: PTHR10177:SF67
db: PANTHER Family
relationship type: By Homology

Cyclin D
type: Protein
entity reference: Cyclin D
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 168
cellular location: Mid G sub 1 endsub c6
comment: SPECIES_TYPE=PROTEIN

PTHR10177:SF71
type: RelationshipXref
id: PTHR10177:SF71
db: PANTHER Family
relationship type: By Homology

uniprot E2QUY7 28
type: UnificationXref
id: E2QUY7
db: uniprot

uniprot F7HMX1 50
type: UnificationXref
id: F7HMX1
db: uniprot

APC
type: Protein
feature: ACTIVE 10
feature: APC s28 a46 rs1
cellular location: Mitosis c5
comment: SPECIES_TYPE=PROTEIN

26S proteasome non-ATPase regulatory subunit 3
type: ProteinReference
xref: PTHR10758:SF2
xref: uniprot Q2KJ46 91
organism: Bos taurus

uniprot Q2KJ25 90
type: UnificationXref
id: Q2KJ25
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 22

uniprot Q1K564 87
type: UnificationXref
id: Q1K564
db: uniprot

PARTICIPANT STOICHIOMETRY r24 191
type: Stoichiometry
physical entity: E2F
stoichiometric coefficient: 1.0

ncbitaxon 9598 7
type: UnificationXref
id: 9598
db: ncbitaxon

APC
type: Protein
feature: APC s69 a94 rs1
cellular location: Mitosis c5
comment: SPECIES_TYPE=PROTEIN

uniprot F6VW96 155
type: UnificationXref
id: F6VW96
db: uniprot

PTHR10410:SF5
type: RelationshipXref
id: PTHR10410:SF5
db: PANTHER Family
relationship type: By Homology

uniprot F6TGA8 2
type: UnificationXref
id: F6TGA8
db: uniprot

Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14
type: ProteinReference
xref: PTHR10410:SF5
xref: uniprot Q17QP9 86
organism: Bos taurus

uniprot A0A2I3RXN8 132
type: UnificationXref
id: A0A2I3RXN8
db: uniprot

G1/S-specific cyclin-D2
type: ProteinReference
xref: PTHR10177:SF66
xref: uniprot P30279 139
organism: Homo sapiens

E2F
type: ProteinReference
xref: P00488
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cell cycle.PROTEIN.GENERIC.E2F
comment: ENTITY_REFERENCE_NOTES=Long Name: E2F Synonym: Synonym not specified Accession: P00488
member entity reference: Transcription factor E2f1
member entity reference: E2F transcription factor 3

uniprot Q387U2 94
type: UnificationXref
id: Q387U2
db: uniprot

ncbitaxon 13616 46
type: UnificationXref
id: 13616
db: ncbitaxon

G1/S-specific cyclin-D3
type: ProteinReference
xref: PTHR10177:SF65
xref: uniprot P30282 142
organism: Mus musculus

uniprot P39948 143
type: UnificationXref
id: P39948
db: uniprot

uniprot Q388E9 95
type: UnificationXref
id: Q388E9
db: uniprot

uniprot P30279 139
type: UnificationXref
id: P30279
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Cdk2-_Cyclin_E-RIGHT__Complex__Cyclin_E_Cdk2_-_r26
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 187
left: Cdk2
left: Cyclin E
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Cyclin E/Cdk2)

G1/S-specific cyclin-D3
type: ProteinReference
xref: uniprot P30281 140
xref: PTHR10177:SF65
organism: Homo sapiens

uniprot Q12377 85
type: UnificationXref
id: Q12377
db: uniprot

ncbitaxon 8364 42
type: UnificationXref
id: 8364
db: ncbitaxon

APC s69 a94 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

26S proteasome non-ATPase regulatory subunit 12 isoform 1
type: ProteinReference
xref: PTHR10855:SF1
xref: uniprot F6UPJ2 40
organism: Macaca mulatta

Complex (Protein kinase subunit/Cyclin B)
type: Complex
component stoichiometry: Protein kinase subunit s9 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cyclin B s10 sa8 STOICHIOMETRY ID COMPLEX
component: Protein kinase subunit
component: Cyclin B
feature: ACTIVE 10
feature: COMPLEX BINDING FEATURE s68 a93 169
feature: COMPLEX BINDING FEATURE s68 a93 171
cellular location: Metaphase c10

uniprot O94444 71
type: UnificationXref
id: O94444
db: uniprot

Cyclin B s12 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cyclin B
stoichiometric coefficient: 1.0

Replication protein A 14 kDa subunit
type: ProteinReference
xref: uniprot P35244 8
xref: PTHR15114:SF1
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QZ01 13
xref: PTHR10660:SF4
organism: Macaca mulatta

eco ECO:0000270 141
type: UnificationXref
id: ECO:0000270
db: eco

STATE_TRANSITION
type: InteractionVocabulary

ncbitaxon 9913 19
type: UnificationXref
id: 9913
db: ncbitaxon

Proteasome 26S subunit, non-ATPase 12
type: ProteinReference
xref: PTHR10855:SF1
xref: uniprot A0A2I3SRL8 16
organism: Pan troglodytes

uniprot Q386U6 92
type: UnificationXref
id: Q386U6
db: uniprot

Cdk2
type: ProteinReference
xref: P00485
comment: ENTITY_REFERENCE_ID_DESC=Cell cycle.PROTEIN.GENERIC.Cdk2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cdk2 Synonym: Synonym not specified Accession: P00485
member entity reference: Uncharacterized protein
member entity reference: Cyclin-dependent kinase 2-interacting protein
member entity reference: CINP isoform 7

STATE_TRANSITION_LEFT__Cyclin_B-RIGHT__Cyclin_B-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 204
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 203
left: Cyclin B
interaction type: STATE_TRANSITION
right: Cyclin B

uniprot H2QIW0 54
type: UnificationXref
id: H2QIW0
db: uniprot

uniprot A0A2I3RFE0 14
type: UnificationXref
id: A0A2I3RFE0
db: uniprot

26S proteasome non-ATPase regulatory subunit 11B
type: ProteinReference
xref: PTHR10678:SF4
xref: uniprot F1QGH9 35
organism: Danio rerio

Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 3
type: ProteinReference
xref: PTHR10758:SF2
xref: uniprot Q5U2S7 105
organism: Rattus norvegicus

uniprot H2R9R9 159
type: UnificationXref
id: H2R9R9
db: uniprot

uniprot O24412 59
type: UnificationXref
id: O24412
db: uniprot

uniprot P61289 83
type: UnificationXref
id: P61289
db: uniprot

uniprot Q9D0V8 150
type: UnificationXref
id: Q9D0V8
db: uniprot

uniprot Q60EW3 107
type: UnificationXref
id: Q60EW3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__APC_-_ATP-RIGHT__APC_-_ADP-_r29
controller: Complex (Protein kinase subunit/Cyclin B)

PSME3 isoform 5
type: ProteinReference
xref: PTHR10660:SF4
xref: uniprot A0A2I3RFE0 14
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Protein_kinase_subunit_Cyclin_B_-RIGHT__Complex__Protein_kinase_subunit_Cyclin_B_-_r31
controller: APC

Leishmania major
type: BioSource
xref: ncbitaxon 5664 99

PTHR10177:SF203
type: RelationshipXref
id: PTHR10177:SF203
db: PANTHER Family
relationship type: By Homology

uniprot O00232 57
type: UnificationXref
id: O00232
db: uniprot

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 77

ncbitaxon 7227 80
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot O43060 67
type: UnificationXref
id: O43060
db: uniprot

Probable 26S proteasome regulatory subunit rpn6
type: ProteinReference
xref: PTHR10678:SF2
xref: uniprot Q9P7S2 114
organism: Schizosaccharomyces pombe

uniprot Q9P7S2 114
type: UnificationXref
id: Q9P7S2
db: uniprot

ncbitaxon 10116 22
type: UnificationXref
id: 10116
db: ncbitaxon

ncbitaxon 559292 76
type: UnificationXref
id: 559292
db: ncbitaxon

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Cdk2-_Cyclin_E-RIGHT__Complex__Cyclin_E_Cdk2_-_r26
controller: E2F

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Q7B1 158
organism: Macaca mulatta

Proteasome regulatory non-ATPase subunit 8
type: ProteinReference
xref: uniprot Q388E9 95
xref: PTHR10540:SF7
organism: Trypanosoma brucei

uniprot P39949 128
type: UnificationXref
id: P39949
db: uniprot

26S proteasome regulatory subunit rpn10
type: ProteinReference
xref: uniprot O94444 71
xref: PTHR10223:SF0
organism: Schizosaccharomyces pombe

Pre-replication Complex
type: ProteinReference
xref: P00478
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Pre-replication Complex Synonym: Synonym not specified Accession: P00478
comment: ENTITY_REFERENCE_ID_DESC=Cell cycle.PROTEIN.GENERIC.Pre-replication_br_Complex
member entity reference: RPA3 isoform 1
member entity reference: Replication protein A 14 kDa subunit

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DST4 48
xref: PTHR10855:SF1
organism: Monodelphis domestica

Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 7 (Predicted)
type: ProteinReference
xref: uniprot D4AEH3 25
xref: PTHR10540:SF7
organism: Rattus norvegicus

PTHR10660:SF4
type: RelationshipXref
id: PTHR10660:SF4
db: PANTHER Family
relationship type: By Homology

uniprot F6V8H8 41
type: UnificationXref
id: F6V8H8
db: uniprot

PTHR10660:SF6
type: RelationshipXref
id: PTHR10660:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q5F3J5 104
type: UnificationXref
id: Q5F3J5
db: uniprot

uniprot O96020 163
type: UnificationXref
id: O96020
db: uniprot

uniprot Q61457 130
type: UnificationXref
id: Q61457
db: uniprot

uniprot F1MV86 134
type: UnificationXref
id: F1MV86
db: uniprot