uniprot Q10231 115
type: UnificationXref
id: Q10231
db: uniprot

2NADPH + H
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P08524 60
type: UnificationXref
id: P08524
db: uniprot

3-hydroxy-3-methylglutaryl coenzyme A synthase
type: ProteinReference
xref: uniprot F7HQ90 120
xref: PTHR43323:SF4
organism: Macaca mulatta

uniprot O65402 74
type: UnificationXref
id: O65402
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__delta3_isopentenyl_pyrophosphate-_Geranyl_pyrophosphate-RIGHT__Farsenyl_pyrophosphate-_PPi-_r21
controller: Geranyl trans-transferase

Squalene synthase
type: ProteinReference
xref: uniprot Q9Y753 144
organism: Yarrowia lipolytica

Cholesterol biosynthesis
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Acetoacetyl_CoA-_Acetyl_CoA-_H2O-RIGHT__CoA_SH-_3_hydroxy_3_methyl_glutaryl_CoA-_r26
pathway component: STATE_TRANSITION_LEFT__ATP-_Mevalonate_5_pyrophosphate-_Mg_PLUS__PLUS_-RIGHT__ADP-_delta3_isopentenyl_pyrophosphate-_r5
pathway component: STATE_TRANSITION_LEFT__2NADPH__PLUS__H-_3_hydroxy_3_methyl_glutaryl_CoA-RIGHT__Mevalonate-_2NADP__PLUS__CoA_SH-_r2
pathway component: STATE_TRANSITION_LEFT__Farsenyl_pyrophosphate-_NADPH__PLUS__H_PLUS_-RIGHT__NADP_PLUS_-_Squalene-_r22
pathway component: STATE_TRANSITION_LEFT__NADPH__PLUS__H_PLUS__O2-_Squalene-RIGHT__Squalene_2,3_epoxide-_NADP__PLUS__H2O-_r23
pathway component: STATE_TRANSITION_LEFT__delta3_isopentenyl_pyrophosphate-_Dimethylallyl_pyrophosphate-RIGHT__PPi-_Geranyl_pyrophosphate-_r7
pathway component: STATE_TRANSITION_LEFT__Mevalonate-_ATP-_Mg_PLUS__PLUS_-RIGHT__ADP-_Mevalonate_5_phosphate-_r3
pathway component: STATE_TRANSITION_LEFT__ATP-_Mevalonate_5_phosphate-_Mg_PLUS__PLUS_-RIGHT__ADP-_Mevalonate_5_pyrophosphate-_r4
pathway component: STATE_TRANSITION_LEFT__delta3_isopentenyl_pyrophosphate-_Geranyl_pyrophosphate-RIGHT__Farsenyl_pyrophosphate-_PPi-_r21
pathway component: STATE_TRANSITION_LEFT__Squalene_2,3_epoxide-RIGHT__Lanosterol-_r24
pathway component: STATE_TRANSITION_LEFT__delta3_isopentenyl_pyrophosphate-_Mg_PLUS__PLUS_-RIGHT__Dimethylallyl_pyrophosphate-_r6
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Lanosterol-RIGHT__Cholesterol-_r28
xref: PANTHER Pathway P00014 1
comment: MODEL_NOTES=This pathway illustrates the events of cholesterol biosynthesis from acetyl CoA to lanosterol. There are an additional nine steps from lanosterol to cholesterol, which are not included here at this time.; Medline=1390320 Medline=3524618

3-hydroxy-3-methylglutaryl coenzyme A synthase
type: ProteinReference
xref: uniprot F7C0S7 119
xref: PTHR43323:SF4
organism: Monodelphis domestica

Evidence 102
type: Evidence
evidence code: TAS
comment: SPACC P53602

uniprot A7Z064 15
type: UnificationXref
id: A7Z064
db: uniprot

3-hydroxy-3-methylglutaryl-coenzyme A reductase
type: ProteinReference
evidence: Evidence 20
evidence: Evidence 18
evidence: Evidence 19
xref: uniprot P04035 31
xref: PTHR10572:SF24
organism: Homo sapiens

STATE_TRANSITION_LEFT__Squalene_2,3_epoxide-RIGHT__Lanosterol-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 168
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 167
left: Squalene 2,3 epoxide
interaction type: STATE_TRANSITION
right: Lanosterol

PTHR10572:SF42
type: RelationshipXref
id: PTHR10572:SF42
db: PANTHER Family
relationship type: By Homology

Lanosterol synthase
type: ProteinReference
evidence: Evidence 109
xref: PTHR11764:SF20
xref: uniprot Q8BLN5 117
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 14

Phosphomevalonate kinase
type: ProteinReference
xref: uniprot Q5RK24 149
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Mevalonate_5_phosphate-_Mg_PLUS__PLUS_-RIGHT__ADP-_Mevalonate_5_pyrophosphate-_r4
controller: Phosphomevalonate kinase

uniprot Q4Q5W4 140
type: UnificationXref
id: Q4Q5W4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H1E7 4
organism: Macaca mulatta

Squalene monooxygenase
type: ProteinReference
xref: uniprot Q14534 81
organism: Homo sapiens

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 61

uniprot Q9C1W3 87
type: UnificationXref
id: Q9C1W3
db: uniprot

uniprot P34136 36
type: UnificationXref
id: P34136
db: uniprot

PARTICIPANT STOICHIOMETRY r4 162
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 64

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 145

PARTICIPANT STOICHIOMETRY r4 163
type: Stoichiometry
physical entity: Mevalonate-5-phosphate
stoichiometric coefficient: 1.0

Hydroxymethylglutaryl-CoA synthase, cytoplasmic
type: ProteinReference
xref: uniprot P23228 123
organism: Gallus gallus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__delta3_isopentenyl_pyrophosphate-_Dimethylallyl_pyrophosphate-RIGHT__PPi-_Geranyl_pyrophosphate-_r7
controller: Dimethylallyl trans-transferase

Terpene cyclase/mutase family member
type: ProteinReference
evidence: Evidence 109
xref: uniprot Q1K768 116
xref: PTHR11764:SF20
organism: Neurospora crassa

Squalene synthase
type: ProteinReference
xref: uniprot P37268 136
organism: Homo sapiens

ncbitaxon 9913 16
type: UnificationXref
id: 9913
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r4 166
type: Stoichiometry
physical entity: Mevalonate-5-pyrophosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 165
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 164
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

uniprot P53799 138
type: UnificationXref
id: P53799
db: uniprot

ncbitaxon 6239 59
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot P29704 134
type: UnificationXref
id: P29704
db: uniprot

Evidence 109
type: Evidence
evidence code: ISS
comment: SPACC P38604

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 70

Acetyl CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Diphosphomevalonate decarboxylase
type: ProteinReference
xref: uniprot Q62967 103
xref: PTHR10977:SF3
organism: Rattus norvegicus

Mevalonate kinase
type: ProteinReference
xref: uniprot F7HGV8 43
xref: PTHR43290:SF2
organism: Macaca mulatta

PTHR10572:SF24
type: RelationshipXref
id: PTHR10572:SF24
db: PANTHER Family
relationship type: By Homology

PTHR43290:SF2
type: RelationshipXref
id: PTHR43290:SF2
db: PANTHER Family
relationship type: By Homology

uniprot O14230 55
type: UnificationXref
id: O14230
db: uniprot

uniprot Q9R008 47
type: UnificationXref
id: Q9R008
db: uniprot

Farnesyl pyrophosphate synthase
type: ProteinReference
evidence: Evidence 50
xref: uniprot P14324 62
xref: PTHR11525:SF0
organism: Homo sapiens

Farnesyl-diphosphate farnesyltransferase
type: Protein
entity reference: Farnesyl-diphosphate farnesyltransferase
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3TD84 130
type: UnificationXref
id: A0A2I3TD84
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 6

ncbitaxon 13616 28
type: UnificationXref
id: 13616
db: ncbitaxon

NADPH + H+ O2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Hydroxymethyl glutaryl CoA synthase
type: Protein
entity reference: Hydroxymethyl glutaryl CoA synthase
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__2NADPH__PLUS__H-_3_hydroxy_3_methyl_glutaryl_CoA-RIGHT__Mevalonate-_2NADP__PLUS__CoA_SH-_r2
controller: Hydroxymethyl glutaryl CoA reductase

STATE_TRANSITION_LEFT__ATP-_Mevalonate_5_phosphate-_Mg_PLUS__PLUS_-RIGHT__ADP-_Mevalonate_5_pyrophosphate-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 166
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 162
left: ATP
left: Mg++
left: Mevalonate-5-phosphate
interaction type: STATE_TRANSITION
right: Mevalonate-5-pyrophosphate
right: ADP

ncbitaxon 5664 83
type: UnificationXref
id: 5664
db: ncbitaxon

3-hydroxy-3-methyl-glutaryl CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q01581 125
type: UnificationXref
id: Q01581
db: uniprot

uniprot H2Q1D7 5
type: UnificationXref
id: H2Q1D7
db: uniprot

ncbitaxon 10116 12
type: UnificationXref
id: 10116
db: ncbitaxon

ncbitaxon 7227 64
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot F6Q304 95
type: UnificationXref
id: F6Q304
db: uniprot

uniprot Q1K768 116
type: UnificationXref
id: Q1K768
db: uniprot

Acetoacetyl CoA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P52020 80
type: UnificationXref
id: P52020
db: uniprot

Diphosphomevalonate decarboxylase
type: ProteinReference
evidence: Evidence 96
xref: uniprot H2QBQ1 97
xref: PTHR10977:SF3
organism: Pan troglodytes

CoA-SH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Anosterol synthase
type: Protein
entity reference: Anosterol synthase
comment: SPECIES_TYPE=PROTEIN

Mevalonate kinase
type: ProteinReference
xref: P00492
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Mevalonate_space_kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Mevalonate kinase Synonym: Synonym not specified Accession: P00492
member entity reference: Mevalonate kinase

Squalene 2,3 epoxide
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot K7AWU9 147
type: UnificationXref
id: K7AWU9
db: uniprot

Hydroxymethyl glutaryl CoA synthase
type: ProteinReference
xref: P00498
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Hydroxymethyl glutaryl CoA synthase Synonym: Synonym not specified Accession: P00498
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Hydroxymethyl_space_glutaryl_br_CoA_space_synthase
member entity reference: Hydroxymethylglutaryl-CoA synthase, cytoplasmic
member entity reference: 3-hydroxy-3-methylglutaryl coenzyme A synthase

uniprot H9EWU0 73
type: UnificationXref
id: H9EWU0
db: uniprot

3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
type: ProteinReference
evidence: Evidence 37
xref: uniprot P34136 36
xref: PTHR10572:SF42
organism: Dictyostelium discoideum

uniprot F6X625 110
type: UnificationXref
id: F6X625
db: uniprot

3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
type: ProteinReference
evidence: Evidence 35
xref: uniprot P34135 32
xref: PTHR10572:SF24
organism: Dictyostelium discoideum

uniprot F7HGV8 43
type: UnificationXref
id: F7HGV8
db: uniprot

uniprot Q4QFZ2 82
type: UnificationXref
id: Q4QFZ2
db: uniprot

uniprot Q9D1G2 150
type: UnificationXref
id: Q9D1G2
db: uniprot

ncbitaxon 39947 54
type: UnificationXref
id: 39947
db: ncbitaxon

Squalene monooxygenase
type: ProteinReference
xref: uniprot Q92206 85
organism: Candida albicans

uniprot F6RJG0 118
type: UnificationXref
id: F6RJG0
db: uniprot

ncbitaxon 237631 143
type: UnificationXref
id: 237631
db: ncbitaxon

PPi
type: SmallMolecule
comment: SPECIES_TYPE=ION

NADPH + H+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Geranylgeranyl pyrophosphate synthase
type: ProteinReference
xref: uniprot O95749 8
organism: Homo sapiens

ncbitaxon 9598 6
type: UnificationXref
id: 9598
db: ncbitaxon

Squalene
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Isopentenyl-diphosphate delta-isomerase 2
type: ProteinReference
xref: PTHR10885:SF1
xref: uniprot Q9BXS1 93
organism: Homo sapiens

uniprot Q8BLN5 117
type: UnificationXref
id: Q8BLN5
db: uniprot

uniprot P23228 123
type: UnificationXref
id: P23228
db: uniprot

uniprot O23722 99
type: UnificationXref
id: O23722
db: uniprot

ncbitaxon 6238 49
type: UnificationXref
id: 6238
db: ncbitaxon

Dimethylallyl pyrophosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9Y753 144
type: UnificationXref
id: Q9Y753
db: uniprot

Phosphomevalonate kinase
type: ProteinReference
xref: P00500
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Phosphomevalonate_space_kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphomevalonate kinase Synonym: Synonym not specified Accession: P00500
member entity reference: Phosphomevalonate kinase
member entity reference: Probable phosphomevalonate kinase

Squalene epoxidase 2, mitochondrial
type: ProteinReference
xref: uniprot O81000 77
organism: Arabidopsis thaliana

uniprot F4JCU3 94
type: UnificationXref
id: F4JCU3
db: uniprot

uniprot Q920E5 67
type: UnificationXref
id: Q920E5
db: uniprot

uniprot F6V051 27
type: UnificationXref
id: F6V051
db: uniprot

uniprot Q04782 114
type: UnificationXref
id: Q04782
db: uniprot

uniprot F7H1E7 4
type: UnificationXref
id: F7H1E7
db: uniprot

PARTICIPANT STOICHIOMETRY r3 172
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Bos taurus
type: BioSource
xref: ncbitaxon 9913 16

PARTICIPANT STOICHIOMETRY r3 173
type: Stoichiometry
physical entity: Mevalonate-5-phosphate
stoichiometric coefficient: 1.0

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 3

PARTICIPANT STOICHIOMETRY r3 170
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Farnesyl pyrophosphate synthase
type: ProteinReference
evidence: Evidence 50
xref: uniprot O14230 55
xref: PTHR11525:SF0
organism: Schizosaccharomyces pombe

uniprot A8XTW8 48
type: UnificationXref
id: A8XTW8
db: uniprot

PARTICIPANT STOICHIOMETRY r3 171
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

uniprot Q9VXQ3 107
type: UnificationXref
id: Q9VXQ3
db: uniprot

STATE_TRANSITION_LEFT__delta3_isopentenyl_pyrophosphate-_Geranyl_pyrophosphate-RIGHT__Farsenyl_pyrophosphate-_PPi-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 188
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 187
left: delta3-isopentenyl pyrophosphate
left: Geranyl pyrophosphate
interaction type: STATE_TRANSITION
right: PPi
right: Farsenyl pyrophosphate

uniprot H2QWP8 72
type: UnificationXref
id: H2QWP8
db: uniprot

Farnesyl pyrophosphate synthase
type: ProteinReference
evidence: Evidence 68
xref: uniprot Q920E5 67
xref: PTHR11525:SF0
organism: Mus musculus

uniprot F7C0S7 119
type: UnificationXref
id: F7C0S7
db: uniprot

ncbitaxon 237561 86
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot F7DMS6 2
type: UnificationXref
id: F7DMS6
db: uniprot

Diphosphomevalonate decarboxylase
type: ProteinReference
xref: uniprot Q7PXV2 104
xref: PTHR10977:SF3
organism: Anopheles gambiae

3-hydroxy-3-methylglutaryl coenzyme A reductase
type: ProteinReference
evidence: Evidence 42
xref: PTHR10572:SF24
xref: uniprot W4XRC0 40
organism: Strongylocentrotus purpuratus

Squalene epoxidase 3
type: ProteinReference
xref: uniprot Q8VYH2 84
organism: Arabidopsis thaliana

Protein CBR-FDPS-1
type: ProteinReference
evidence: Evidence 50
xref: uniprot A8XTW8 48
xref: PTHR11525:SF0
organism: Caenorhabditis briggsae

ncbitaxon 5786 25
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot P53798 137
type: UnificationXref
id: P53798
db: uniprot

NADP + H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r3 169
type: Stoichiometry
physical entity: Mevalonate
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__delta3_isopentenyl_pyrophosphate-_Mg_PLUS__PLUS_-RIGHT__Dimethylallyl_pyrophosphate-_r6
controller: Isopentenyl diphosphate delta-isomerase

uniprot P34135 32
type: UnificationXref
id: P34135
db: uniprot

FDFT1 protein
type: ProteinReference
xref: uniprot Q6IE76 141
organism: Bos taurus

Squalene monooxygenase
type: ProteinReference
xref: uniprot P52019 79
organism: Mus musculus

uniprot O13963 98
type: UnificationXref
id: O13963
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 23

Os03g0805100 protein
type: ProteinReference
xref: uniprot O22105 132
organism: Oryza sativa

uniprot Q7QIW5 65
type: UnificationXref
id: Q7QIW5
db: uniprot

3-hydroxy-3-methylglutaryl coenzyme A synthase
type: ProteinReference
xref: uniprot H2QQU5 121
xref: PTHR43323:SF4
organism: Pan troglodytes

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 124

Probable squalene monooxygenase
type: ProteinReference
xref: uniprot Q9C1W3 87
organism: Schizosaccharomyces pombe

Squalene monooxygenase
type: ProteinReference
xref: uniprot P52020 80
organism: Rattus norvegicus

Diphosphomevalonate decarboxylase MVD2, peroxisomal
type: ProteinReference
xref: uniprot F4JCU3 94
xref: PTHR10977:SF3
organism: Arabidopsis thaliana

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Mevalonate-_ATP-_Mg_PLUS__PLUS_-RIGHT__ADP-_Mevalonate_5_phosphate-_r3
controller: Mevalonate kinase

uniprot Q9BXS1 93
type: UnificationXref
id: Q9BXS1
db: uniprot

Isopentenyl-diphosphate delta-isomerase 2
type: ProteinReference
xref: PTHR10885:SF2
xref: uniprot Q8BFZ6 92
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r26 156
type: Stoichiometry
physical entity: 3-hydroxy-3-methyl-glutaryl CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 155
type: Stoichiometry
physical entity: CoA-SH
stoichiometric coefficient: 1.0

uniprot F7HQ90 120
type: UnificationXref
id: F7HQ90
db: uniprot

PARTICIPANT STOICHIOMETRY r26 154
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 153
type: Stoichiometry
physical entity: Acetyl CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 152
type: Stoichiometry
physical entity: Acetoacetyl CoA
stoichiometric coefficient: 1.0

3-hydroxy-3-methylglutaryl coenzyme A reductase
type: ProteinReference
evidence: Evidence 20
evidence: Evidence 18
evidence: Evidence 19
xref: uniprot F7HJ02 29
xref: PTHR10572:SF24
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Mevalonate_5_pyrophosphate-_Mg_PLUS__PLUS_-RIGHT__ADP-_delta3_isopentenyl_pyrophosphate-_r5
controller: Diphosphomevalonate decarboxylase

uniprot Q15126 148
type: UnificationXref
id: Q15126
db: uniprot

STATE_TRANSITION_LEFT__ATP-_Mevalonate_5_pyrophosphate-_Mg_PLUS__PLUS_-RIGHT__ADP-_delta3_isopentenyl_pyrophosphate-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 159
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 161
left: ATP
left: Mg++
left: Mevalonate-5-pyrophosphate
interaction type: STATE_TRANSITION
right: delta3-isopentenyl pyrophosphate
right: ADP

uniprot F7FI27 51
type: UnificationXref
id: F7FI27
db: uniprot

Diphosphomevalonate decarboxylase
type: ProteinReference
xref: uniprot O13963 98
xref: PTHR10977:SF3
organism: Schizosaccharomyces pombe

uniprot A0A2I3RGG5 108
type: UnificationXref
id: A0A2I3RGG5
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

NADP+
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P36596 135
type: UnificationXref
id: P36596
db: uniprot

Hydroxymethyl glutaryl CoA reductase
type: Protein
entity reference: Hydroxymethyl glutaryl CoA reductase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 3702 75
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot Q99JF5 105
type: UnificationXref
id: Q99JF5
db: uniprot

Decaprenyl diphosphate synthase subunit 1
type: ProteinReference
xref: uniprot K6Z8K5 7
organism: Pan troglodytes

uniprot Q7KN61 63
type: UnificationXref
id: Q7KN61
db: uniprot

ncbitaxon 284591 145
type: UnificationXref
id: 284591
db: ncbitaxon

Geranylgeranyl pyrophosphate synthase
type: ProteinReference
xref: uniprot Q6F596 11
organism: Rattus norvegicus

PTHR10977:SF3
type: RelationshipXref
id: PTHR10977:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q03426 45
type: UnificationXref
id: Q03426
db: uniprot

Decaprenyl-diphosphate synthase subunit 1
type: ProteinReference
xref: uniprot Q5T2R2 10
organism: Homo sapiens

Isopentenyl-diphosphate Delta-isomerase 1
type: ProteinReference
xref: uniprot P58044 91
xref: PTHR10885:SF5
organism: Mus musculus

3-hydroxy-3-methylglutaryl-coenzyme A reductase
type: ProteinReference
evidence: Evidence 20
evidence: Evidence 18
evidence: Evidence 19
xref: uniprot Q01237 39
xref: PTHR10572:SF24
organism: Mus musculus

Farnesyl pyrophosphate synthase
type: ProteinReference
evidence: Evidence 50
xref: uniprot Q7KN61 63
xref: PTHR11525:SF0
organism: Drosophila melanogaster

uniprot Q6F596 11
type: UnificationXref
id: Q6F596
db: uniprot

uniprot P52019 79
type: UnificationXref
id: P52019
db: uniprot

PTHR10885:SF1
type: RelationshipXref
id: PTHR10885:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q7PXV2 104
type: UnificationXref
id: Q7PXV2
db: uniprot

STATE_TRANSITION_LEFT__2NADPH__PLUS__H-_3_hydroxy_3_methyl_glutaryl_CoA-RIGHT__Mevalonate-_2NADP__PLUS__CoA_SH-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 180
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 181
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 178
left: 3-hydroxy-3-methyl-glutaryl CoA
left: 2NADPH + H
interaction type: STATE_TRANSITION
right: 2NADP + CoA-SH
right: Mevalonate

PTHR10885:SF2
type: RelationshipXref
id: PTHR10885:SF2
db: PANTHER Family
relationship type: By Homology

Geranyl trans-transferase
type: Protein
entity reference: Geranyl trans-transferase
comment: SPECIES_TYPE=PROTEIN

uniprot P48449 112
type: UnificationXref
id: P48449
db: uniprot

Diphosphomevalonate decarboxylase
type: ProteinReference
evidence: Evidence 96
xref: uniprot F6Q304 95
xref: PTHR10977:SF3
organism: Macaca mulatta

PTHR10885:SF5
type: RelationshipXref
id: PTHR10885:SF5
db: PANTHER Family
relationship type: By Homology

uniprot P14324 62
type: UnificationXref
id: P14324
db: uniprot

uniprot O04882 53
type: UnificationXref
id: O04882
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 49

uniprot Q9SM02 88
type: UnificationXref
id: Q9SM02
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 59

uniprot Q5RK24 149
type: UnificationXref
id: Q5RK24
db: uniprot

uniprot Q02769 139
type: UnificationXref
id: Q02769
db: uniprot

STATE_TRANSITION_LEFT__NADPH__PLUS__H_PLUS__O2-_Squalene-RIGHT__Squalene_2,3_epoxide-_NADP__PLUS__H2O-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 177
left: Squalene
left: NADPH + H+ O2
interaction type: STATE_TRANSITION
right: NADP + H2O
right: Squalene 2,3 epoxide

Cholesterol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Acetoacetyl_CoA-_Acetyl_CoA-_H2O-RIGHT__CoA_SH-_3_hydroxy_3_methyl_glutaryl_CoA-_r26
controller: Hydroxymethyl glutaryl CoA synthase

delta3-isopentenyl pyrophosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PANTHER Pathway P00014 1
type: UnificationXref
id: P00014
db: PANTHER Pathway

Isopentenyl-diphosphate Delta-isomerase 1
type: ProteinReference
evidence: Evidence 90
xref: PTHR10885:SF5
xref: uniprot O35760 89
organism: Rattus norvegicus

Mevalonate kinase
type: Protein
entity reference: Mevalonate kinase
comment: SPECIES_TYPE=PROTEIN

uniprot O22105 132
type: UnificationXref
id: O22105
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 54

uniprot O65688 133
type: UnificationXref
id: O65688
db: uniprot

uniprot Q14534 81
type: UnificationXref
id: Q14534
db: uniprot

Squalene epoxidase 1
type: ProteinReference
xref: uniprot Q9SM02 88
organism: Arabidopsis thaliana

uniprot Q8JZK9 128
type: UnificationXref
id: Q8JZK9
db: uniprot

uniprot P51639 38
type: UnificationXref
id: P51639
db: uniprot

uniprot Q92459 142
type: UnificationXref
id: Q92459
db: uniprot

Phosphomevalonate kinase
type: ProteinReference
xref: uniprot Q9D1G2 150
organism: Mus musculus

SQLE isoform 2
type: ProteinReference
xref: uniprot H2QWP8 72
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r2 179
type: Stoichiometry
physical entity: 3-hydroxy-3-methyl-glutaryl CoA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 178
type: Stoichiometry
physical entity: 2NADPH + H
stoichiometric coefficient: 1.0

3-hydroxy-3-methylglutaryl coenzyme A reductase
type: ProteinReference
evidence: Evidence 26
xref: uniprot F0ZER0 24
xref: PTHR10572:SF42
organism: Dictyostelium purpureum

ncbitaxon 9544 3
type: UnificationXref
id: 9544
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r28 191
type: Stoichiometry
physical entity: Cholesterol
stoichiometric coefficient: 1.0

Evidence 18
type: Evidence
evidence code: ISS
comment: SPACC P00347

PARTICIPANT STOICHIOMETRY r28 190
type: Stoichiometry
physical entity: Lanosterol
stoichiometric coefficient: 1.0

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 66

uniprot P58044 91
type: UnificationXref
id: P58044
db: uniprot

Diphosphomevalonate decarboxylase
type: ProteinReference
evidence: Evidence 102
xref: uniprot P53602 101
xref: PTHR10977:SF3
organism: Homo sapiens

Diphosphomevalonate decarboxylase
type: ProteinReference
xref: P00496
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Diphosphomevalonate_br_decarboxylase
comment: ENTITY_REFERENCE_NOTES=Long Name: Diphosphomevalonate decarboxylase Synonym: Synonym not specified Accession: P00496
member entity reference: Diphosphomevalonate decarboxylase MVD1, peroxisomal
member entity reference: Diphosphomevalonate decarboxylase
member entity reference: Diphosphomevalonate decarboxylase MVD2, peroxisomal

PTHR11525:SF0
type: RelationshipXref
id: PTHR11525:SF0
db: PANTHER Family
relationship type: By Homology

Diphosphomevalonate decarboxylase
type: ProteinReference
xref: uniprot Q9U294 106
xref: PTHR10977:SF3
organism: Caenorhabditis elegans

Farnesyl pyrophosphate synthase
type: ProteinReference
evidence: Evidence 50
xref: PTHR11525:SF0
xref: uniprot P08524 60
organism: Saccharomyces cerevisiae

ncbitaxon 367110 70
type: UnificationXref
id: 367110
db: ncbitaxon

Evidence 19
type: Evidence
evidence code: ISS
comment: SPACC P09610

Lanosterol synthase
type: ProteinReference
evidence: Evidence 109
xref: PTHR11764:SF20
xref: uniprot P48449 112
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r2 181
type: Stoichiometry
physical entity: 2NADP + CoA-SH
stoichiometric coefficient: 1.0

Evidence 26
type: Evidence
evidence code: ISS
comment: SPACC P34136

uniprot Q9VIT2 151
type: UnificationXref
id: Q9VIT2
db: uniprot

PARTICIPANT STOICHIOMETRY r2 180
type: Stoichiometry
physical entity: Mevalonate
stoichiometric coefficient: 1.0

3-hydroxy-3-methylglutaryl coenzyme A synthase
type: ProteinReference
xref: uniprot F6RJG0 118
xref: PTHR43323:SF4
organism: Bos taurus

Farnesyl diphosphate synthase
type: ProteinReference
evidence: Evidence 50
xref: PTHR11525:SF0
xref: uniprot Q9NH03 71
organism: Dictyostelium discoideum

3-hydroxy-3-methylglutaryl coenzyme A synthase
type: ProteinReference
xref: uniprot Q7K4Q9 126
organism: Drosophila melanogaster

Evidence 20
type: Evidence
evidence code: ISS
comment: SPACC Q29512

Terpene cyclase/mutase family member
type: ProteinReference
evidence: Evidence 109
xref: PTHR11764:SF20
xref: uniprot A0A2I3RGG5 108
organism: Pan troglodytes

Lanosterol synthase
type: ProteinReference
evidence: Evidence 109
xref: uniprot P48450 113
xref: PTHR11764:SF20
organism: Rattus norvegicus

Squalene monooxygenase
type: ProteinReference
xref: uniprot P32476 78
organism: Saccharomyces cerevisiae

eco ECO:0000250 17
type: UnificationXref
id: ECO:0000250
db: eco

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 17

uniprot O81000 77
type: UnificationXref
id: O81000
db: uniprot

Terpene cyclase/mutase family member
type: ProteinReference
evidence: Evidence 109
xref: uniprot F6X625 110
xref: PTHR11764:SF20
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r24 167
type: Stoichiometry
physical entity: Squalene 2,3 epoxide
stoichiometric coefficient: 1.0

GGPS1 isoform 1
type: ProteinReference
xref: uniprot H2Q1D7 5
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r24 168
type: Stoichiometry
physical entity: Lanosterol
stoichiometric coefficient: 1.0

Farnesyl diphosphate synthase
type: ProteinReference
evidence: Evidence 50
xref: PTHR11525:SF0
xref: uniprot O04882 53
organism: Oryza sativa

P00500
type: UnificationXref
id: P00500
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r23 174
type: Stoichiometry
physical entity: NADPH + H+ O2
stoichiometric coefficient: 1.0

Lanosterol synthase
type: ProteinReference
evidence: Evidence 109
xref: PTHR11764:SF20
xref: uniprot Q10231 115
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r23 175
type: Stoichiometry
physical entity: Squalene
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 176
type: Stoichiometry
physical entity: Squalene 2,3 epoxide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 177
type: Stoichiometry
physical entity: NADP + H2O
stoichiometric coefficient: 1.0

3-hydroxy-3-methylglutaryl-coenzyme A reductase
type: ProteinReference
evidence: Evidence 20
evidence: Evidence 18
evidence: Evidence 19
xref: uniprot A7Z064 15
xref: PTHR10572:SF24
organism: Bos taurus

uniprot E2R9Z3 22
type: UnificationXref
id: E2R9Z3
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 28

ncbitaxon 44689 33
type: UnificationXref
id: 44689
db: ncbitaxon

ncbitaxon 9615 23
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot O65404 76
type: UnificationXref
id: O65404
db: uniprot

uniprot Q62967 103
type: UnificationXref
id: Q62967
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 56

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DMS6 2
organism: Macaca mulatta

Squalene monooxygenase
type: ProteinReference
xref: uniprot H9EWU0 73
organism: Macaca mulatta

Hydroxymethylglutaryl-CoA synthase, cytoplasmic
type: ProteinReference
xref: PTHR43323:SF4
xref: uniprot Q01581 125
organism: Homo sapiens

3-hydroxy-3-methylglutaryl coenzyme A synthase
type: ProteinReference
xref: uniprot Q7Q6H2 127
organism: Anopheles gambiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Squalene_2,3_epoxide-RIGHT__Lanosterol-_r24
controller: Anosterol synthase

uniprot A0A1D5QYJ8 129
type: UnificationXref
id: A0A1D5QYJ8
db: uniprot

Mevalonate-5-pyrophosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR11764:SF20
type: RelationshipXref
id: PTHR11764:SF20
db: PANTHER Family
relationship type: By Homology

uniprot Q5T2R2 10
type: UnificationXref
id: Q5T2R2
db: uniprot

PARTICIPANT STOICHIOMETRY r5 161
type: Stoichiometry
physical entity: delta3-isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

uniprot P32476 78
type: UnificationXref
id: P32476
db: uniprot

uniprot O59703 57
type: UnificationXref
id: O59703
db: uniprot

PARTICIPANT STOICHIOMETRY r5 160
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

3-hydroxy-3-methylglutaryl-coenzyme A reductase
type: ProteinReference
evidence: Evidence 20
evidence: Evidence 18
evidence: Evidence 19
xref: uniprot P51639 38
xref: PTHR10572:SF24
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__delta3_isopentenyl_pyrophosphate-_Dimethylallyl_pyrophosphate-RIGHT__PPi-_Geranyl_pyrophosphate-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 194
left: delta3-isopentenyl pyrophosphate
left: Dimethylallyl pyrophosphate
interaction type: STATE_TRANSITION
right: Geranyl pyrophosphate
right: PPi

3-hydroxy-3-methylglutaryl coenzyme A reductase
type: ProteinReference
evidence: Evidence 20
evidence: Evidence 18
evidence: Evidence 19
xref: uniprot K7C0P4 30
xref: PTHR10572:SF24
organism: Pan troglodytes

Dimethylallyl trans-transferase
type: Protein
entity reference: Dimethylallyl trans-transferase
comment: SPECIES_TYPE=PROTEIN

uniprot P17425 122
type: UnificationXref
id: P17425
db: uniprot

uniprot Q6IE76 141
type: UnificationXref
id: Q6IE76
db: uniprot

PARTICIPANT STOICHIOMETRY r21 186
type: Stoichiometry
physical entity: delta3-isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

eco ECO:0000304 34
type: UnificationXref
id: ECO:0000304
db: eco

Isopentenyl diphosphate delta-isomerase
type: Protein
entity reference: Isopentenyl diphosphate delta-isomerase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r21 188
type: Stoichiometry
physical entity: Farsenyl pyrophosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 187
type: Stoichiometry
physical entity: Geranyl pyrophosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 189
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

3-hydroxy-3-methylglutaryl coenzyme A reductase
type: ProteinReference
evidence: Evidence 20
evidence: Evidence 18
evidence: Evidence 19
xref: uniprot E2R9Z3 22
xref: PTHR10572:SF24
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r5 157
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 158
type: Stoichiometry
physical entity: Mevalonate-5-pyrophosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 159
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

AGAP007104-PA
type: ProteinReference
evidence: Evidence 50
xref: uniprot Q7QIW5 65
xref: PTHR11525:SF0
organism: Anopheles gambiae

Farnesyl DiPhosphate Synthetase
type: ProteinReference
evidence: Evidence 50
xref: uniprot O62336 58
xref: PTHR11525:SF0
organism: Caenorhabditis elegans

Diphosphomevalonate decarboxylase
type: ProteinReference
xref: uniprot Q9VXQ3 107
xref: PTHR10977:SF3
organism: Drosophila melanogaster

Squalene monooxygenas
type: Protein
entity reference: Squalene monooxygenas
comment: SPECIES_TYPE=PROTEIN

uniprot Q7K4Q9 126
type: UnificationXref
id: Q7K4Q9
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 9

Diphosphomevalonate decarboxylase
type: ProteinReference
xref: uniprot P32377 100
xref: PTHR10977:SF3
organism: Saccharomyces cerevisiae

Farnesyl-diphosphate farnesyltransferase
type: ProteinReference
xref: P00499
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Farnesyl-diphosphate_br_farnesyltransferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Farnesyl-diphosphate farnesyltransferase Synonym: farnesyltransferase,presqualene-di-diphosphate synthase,squalene synthase Accession: P00499
member entity reference: Squalene synthase
member entity reference: Uncharacterized protein
member entity reference: Inactive squalene synthase 2
member entity reference: Squalene synthase 1
member entity reference: FDFT1 protein
member entity reference: FDFT1 isoform 19
member entity reference: Putative squalene synthase
member entity reference: Os03g0805100 protein
member entity reference: Farnesyl-diphosphate farnesyltransferase 1

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 75

FDFT1 isoform 19
type: ProteinReference
xref: uniprot A0A2I3TD84 130
organism: Pan troglodytes

uniprot Q92250 69
type: UnificationXref
id: Q92250
db: uniprot

Mevalonate kinase
type: ProteinReference
xref: PTHR43290:SF2
xref: uniprot Q03426 45
organism: Homo sapiens

Lanosterol synthase
type: ProteinReference
evidence: Evidence 109
xref: PTHR11764:SF20
xref: uniprot P38604 111
organism: Saccharomyces cerevisiae

Isopentenyl diphosphate delta-isomerase
type: ProteinReference
xref: P00495
comment: ENTITY_REFERENCE_NOTES=Long Name: Isopentenyl diphosphate delta-isomerase Synonym: IPP isomerase,isopentenyl pyrophosphate isomerase,isopentenylpyrophosphate delta-isomerase,methylbutenylpyrophosphate isomerase Accession: P00495
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Isopentenyl_space_diphosphate_space__delta__minus_isomerase
member entity reference: Isopentenyl-diphosphate delta-isomerase 2
member entity reference: Isopentenyl-diphosphate Delta-isomerase 1

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 41

Squalene synthase
type: ProteinReference
xref: uniprot P29704 134
organism: Saccharomyces cerevisiae

Squalene synthase
type: ProteinReference
xref: uniprot P36596 135
organism: Schizosaccharomyces pombe

Phosphomevalonate kinase
type: ProteinReference
xref: uniprot F1MY26 146
organism: Bos taurus

ncbitaxon 9606 9
type: UnificationXref
id: 9606
db: ncbitaxon

P00499
type: UnificationXref
id: P00499
db: PANTHER Pathway Component

P00495
type: UnificationXref
id: P00495
db: PANTHER Pathway Component

uniprot Q8VYH2 84
type: UnificationXref
id: Q8VYH2
db: uniprot

P00496
type: UnificationXref
id: P00496
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__Farsenyl_pyrophosphate-_NADPH__PLUS__H_PLUS_-RIGHT__NADP_PLUS_-_Squalene-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 184
left: NADPH + H+
left: Farsenyl pyrophosphate
interaction type: STATE_TRANSITION
right: NADP+
right: Squalene

P00497
type: UnificationXref
id: P00497
db: PANTHER Pathway Component

P00498
type: UnificationXref
id: P00498
db: PANTHER Pathway Component

P00491
type: UnificationXref
id: P00491
db: PANTHER Pathway Component

P00492
type: UnificationXref
id: P00492
db: PANTHER Pathway Component

uniprot W4XRC0 40
type: UnificationXref
id: W4XRC0
db: uniprot

P00493
type: UnificationXref
id: P00493
db: PANTHER Pathway Component

P00494
type: UnificationXref
id: P00494
db: PANTHER Pathway Component

Squalene synthase
type: ProteinReference
xref: uniprot Q92459 142
organism: Ustilago maydis

P00490
type: UnificationXref
id: P00490
db: PANTHER Pathway Component

uniprot F0ZER0 24
type: UnificationXref
id: F0ZER0
db: uniprot

uniprot O35760 89
type: UnificationXref
id: O35760
db: uniprot

Lanosterol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Evidence 96
type: Evidence
evidence code: ISS
comment: SPACC P53602

uniprot P32377 100
type: UnificationXref
id: P32377
db: uniprot

Squalene monooxygenase-like protein
type: ProteinReference
xref: uniprot Q4QFZ2 82
organism: Leishmania major

Evidence 90
type: Evidence
evidence code: ISS
comment: SPACC O35586

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 143

Squalene epoxidase 6
type: ProteinReference
xref: uniprot O65402 74
organism: Arabidopsis thaliana

Squalene epoxidase 5
type: ProteinReference
xref: uniprot O65404 76
organism: Arabidopsis thaliana

Farnesyl-diphosphate farnesyltransferase 1
type: ProteinReference
xref: uniprot E2R6N6 131
organism: Canis lupus familiaris

Mevalonate kinase
type: ProteinReference
xref: uniprot Q9R008 47
organism: Mus musculus

uniprot Q7Q6H2 127
type: UnificationXref
id: Q7Q6H2
db: uniprot

By Homology
type: RelationshipTypeVocabulary

Diphosphomevalonate decarboxylase
type: Protein
entity reference: Diphosphomevalonate decarboxylase
comment: SPECIES_TYPE=PROTEIN

Farnesyl pyrophosphate synthase
type: ProteinReference
evidence: Evidence 50
xref: uniprot Q92250 69
xref: PTHR11525:SF0
organism: Neurospora crassa

uniprot Q9WTN0 13
type: UnificationXref
id: Q9WTN0
db: uniprot

Phosphomevalonate kinase
type: Protein
entity reference: Phosphomevalonate kinase
comment: SPECIES_TYPE=PROTEIN

uniprot F7HJ02 29
type: UnificationXref
id: F7HJ02
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Farsenyl_pyrophosphate-_NADPH__PLUS__H_PLUS_-RIGHT__NADP_PLUS_-_Squalene-_r22
controller: Farnesyl-diphosphate farnesyltransferase

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 33

Diphosphomevalonate decarboxylase
type: ProteinReference
xref: uniprot Q99JF5 105
xref: PTHR10977:SF3
organism: Mus musculus

Hydroxymethyl glutaryl CoA reductase
type: ProteinReference
xref: P00491
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Hydroxymethyl_space_glutaryl_br_CoA_space_reductase
comment: ENTITY_REFERENCE_NOTES=Long Name: Hydroxymethyl glutaryl CoA reductase Synonym: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Accession: P00491
member entity reference: 3-hydroxy-3-methylglutaryl coenzyme A reductase
member entity reference: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
member entity reference: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
member entity reference: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q9NH03 71
type: UnificationXref
id: Q9NH03
db: uniprot

Geranyl pyrophosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

3-hydroxy-3-methylglutaryl coenzyme A reductase
type: ProteinReference
evidence: Evidence 20
xref: uniprot F6V051 27
xref: PTHR10572:SF24
organism: Monodelphis domestica

uniprot Q8BFZ6 92
type: UnificationXref
id: Q8BFZ6
db: uniprot

uniprot H2QQU5 121
type: UnificationXref
id: H2QQU5
db: uniprot

uniprot P37268 136
type: UnificationXref
id: P37268
db: uniprot

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 34

KNOWN_TRANSITION_OMITTED_LEFT__Lanosterol-RIGHT__Cholesterol-_r28
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY r28 190
left: Lanosterol
interaction type: KNOWN_TRANSITION_OMITTED
right: Cholesterol

Inactive squalene synthase 2
type: ProteinReference
xref: uniprot O65688 133
organism: Arabidopsis thaliana

Mevalonate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P38604 111
type: UnificationXref
id: P38604
db: uniprot

Dimethylallyl trans-transferase
type: ProteinReference
xref: P00490
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Dimethylallyl_space_trans_minus_transferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Dimethylallyl trans-transferase Synonym: dimethylallyltransferase,geranyl-diphosphate synthase,prenyltransferase Accession: P00490
member entity reference: Geranylgeranyl pyrophosphate synthase
member entity reference: Decaprenyl-diphosphate synthase subunit 1
member entity reference: GGPS1 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Decaprenyl diphosphate synthase subunit 1

uniprot K6Z8K5 7
type: UnificationXref
id: K6Z8K5
db: uniprot

uniprot P48450 113
type: UnificationXref
id: P48450
db: uniprot

uniprot H2Q079 52
type: UnificationXref
id: H2Q079
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 12

Phosphomevalonate kinase
type: ProteinReference
xref: uniprot K7AWU9 147
organism: Pan troglodytes

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 10090 14
type: UnificationXref
id: 10090
db: ncbitaxon

Squalene synthase
type: ProteinReference
xref: uniprot P53798 137
organism: Mus musculus

uniprot O95749 8
type: UnificationXref
id: O95749
db: uniprot

Mevalonate-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r7 192
type: Stoichiometry
physical entity: delta3-isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 193
type: Stoichiometry
physical entity: Dimethylallyl pyrophosphate
stoichiometric coefficient: 1.0

Squalene synthase 1
type: ProteinReference
xref: uniprot P53799 138
organism: Arabidopsis thaliana

ncbitaxon 7165 66
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot Q92206 85
type: UnificationXref
id: Q92206
db: uniprot

STATE_TRANSITION_LEFT__Mevalonate-_ATP-_Mg_PLUS__PLUS_-RIGHT__ADP-_Mevalonate_5_phosphate-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 172
left: ATP
left: Mg++
left: Mevalonate
interaction type: STATE_TRANSITION
right: Mevalonate-5-phosphate
right: ADP

PARTICIPANT STOICHIOMETRY r6 196
type: Stoichiometry
physical entity: delta3-isopentenyl pyrophosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 197
type: Stoichiometry
physical entity: Mg++
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 198
type: Stoichiometry
physical entity: Dimethylallyl pyrophosphate
stoichiometric coefficient: 1.0

uniprot Q9U294 106
type: UnificationXref
id: Q9U294
db: uniprot

ncbitaxon 9031 124
type: UnificationXref
id: 9031
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QYJ8 129
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r7 195
type: Stoichiometry
physical entity: Geranyl pyrophosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 194
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

Phosphomevalonate kinase
type: ProteinReference
xref: uniprot Q15126 148
organism: Homo sapiens

2NADP + CoA-SH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2Q6U7 44
type: UnificationXref
id: H2Q6U7
db: uniprot

Lanosterol synthase
type: ProteinReference
evidence: Evidence 109
xref: uniprot Q04782 114
xref: PTHR11764:SF20
organism: Candida albicans

Geranylgeranyl pyrophosphate synthase
type: ProteinReference
xref: uniprot Q9WTN0 13
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
evidence: Evidence 50
xref: uniprot F7FI27 51
xref: PTHR11525:SF0
organism: Macaca mulatta

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

ncbitaxon 7668 41
type: UnificationXref
id: 7668
db: ncbitaxon

Evidence 50
type: Evidence
evidence code: ISS
comment: SPACC O64905

uniprot P53602 101
type: UnificationXref
id: P53602
db: uniprot

uniprot H2QBQ1 97
type: UnificationXref
id: H2QBQ1
db: uniprot

Farsenyl pyrophosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 284812 56
type: UnificationXref
id: 284812
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH__PLUS__H_PLUS__O2-_Squalene-RIGHT__Squalene_2,3_epoxide-_NADP__PLUS__H2O-_r23
controller: Squalene monooxygenas

Squalene synthase
type: ProteinReference
xref: uniprot Q02769 139
organism: Rattus norvegicus

Probable phosphomevalonate kinase
type: ProteinReference
xref: uniprot Q9VIT2 151
organism: Drosophila melanogaster

Mevalonate kinase
type: ProteinReference
xref: PTHR43290:SF2
xref: uniprot H2Q6U7 44
organism: Pan troglodytes

HETERODIMER_ASSOCIATION_LEFT__Acetoacetyl_CoA-_Acetyl_CoA-_H2O-RIGHT__CoA_SH-_3_hydroxy_3_methyl_glutaryl_CoA-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 154
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 153
left: H2O
left: Acetoacetyl CoA
left: Acetyl CoA
interaction type: HETERODIMER_ASSOCIATION
right: 3-hydroxy-3-methyl-glutaryl CoA
right: CoA-SH

STATE_TRANSITION
type: InteractionVocabulary

STATE_TRANSITION_LEFT__delta3_isopentenyl_pyrophosphate-_Mg_PLUS__PLUS_-RIGHT__Dimethylallyl_pyrophosphate-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 198
left: delta3-isopentenyl pyrophosphate
left: Mg++
interaction type: STATE_TRANSITION
right: Dimethylallyl pyrophosphate

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Anosterol synthase
type: ProteinReference
xref: P00497
comment: ENTITY_REFERENCE_NOTES=Long Name: Anosterol synthase Synonym: Lanosterol synthase Accession: P00497
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Anosterol_space_synthase
member entity reference: Lanosterol synthase
member entity reference: Terpene cyclase/mutase family member

uniprot K7C0P4 30
type: UnificationXref
id: K7C0P4
db: uniprot

Evidence 68
type: Evidence
evidence code: ISS
comment: SPACC Q92235

Candida albicans
type: BioSource
xref: ncbitaxon 237561 86

uniprot O62336 58
type: UnificationXref
id: O62336
db: uniprot

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 25

Squalene monooxygenas
type: ProteinReference
xref: P00494
standard name: Squalene monooxygenase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Squalene_space_monooxygenas
comment: ENTITY_REFERENCE_NOTES=Long Name: Squalene monooxygenase Synonym: squalene epoxidase Accession: P00494
member entity reference: Squalene monooxygenase
member entity reference: Squalene epoxidase 5
member entity reference: Squalene epoxidase 3
member entity reference: Squalene monooxygenase-like protein
member entity reference: Squalene epoxidase 1
member entity reference: SQLE isoform 2
member entity reference: Squalene epoxidase 2, mitochondrial
member entity reference: Probable squalene monooxygenase
member entity reference: Squalene epoxidase 6

Hydroxymethylglutaryl-CoA synthase, cytoplasmic
type: ProteinReference
xref: uniprot P17425 122
xref: PTHR43323:SF4
organism: Rattus norvegicus

Putative squalene synthase
type: ProteinReference
xref: uniprot Q4Q5W4 140
organism: Leishmania major

uniprot F1MY26 146
type: UnificationXref
id: F1MY26
db: uniprot

IDA
type: EvidenceCodeVocabulary

Leishmania major
type: BioSource
xref: ncbitaxon 5664 83

FDPS isoform 4
type: ProteinReference
evidence: Evidence 50
xref: uniprot H2Q079 52
xref: PTHR11525:SF0
organism: Pan troglodytes

ncbitaxon 559292 61
type: UnificationXref
id: 559292
db: ncbitaxon

Evidence 35
type: Evidence
evidence code: TAS
comment: SPACC P34135

Evidence 37
type: Evidence
evidence code: TAS
comment: SPACC P34136

uniprot E2R6N6 131
type: UnificationXref
id: E2R6N6
db: uniprot

Geranylgeranyl pyrophosphate synthase
type: ProteinReference
evidence: Evidence 50
xref: uniprot O59703 57
xref: PTHR11525:SF0
organism: Schizosaccharomyces pombe

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Evidence 42
type: Evidence
evidence code: TAS
comment: SPACC P16393

Mg++
type: SmallMolecule
comment: SPECIES_TYPE=ION

Geranyl trans-transferase
type: ProteinReference
xref: P00493
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cholesterol biosynthesis.PROTEIN.GENERIC.Geranyl_space_trans_minus_transferase
comment: ENTITY_REFERENCE_NOTES=Long Name: Geranyl trans-transferase Synonym: FPP synthetase,farnesyl diphosphate synthetase,farnesyl pyrophosphate synthetase,farnesyl-diphosphate synthase Accession: P00493
member entity reference: Farnesyl diphosphate synthase
member entity reference: Farnesyl pyrophosphate synthase
member entity reference: FDPS isoform 4
member entity reference: AGAP007104-PA
member entity reference: Protein CBR-FDPS-1
member entity reference: Geranylgeranyl pyrophosphate synthase
member entity reference: Uncharacterized protein
member entity reference: Farnesyl DiPhosphate Synthetase

uniprot P04035 31
type: UnificationXref
id: P04035
db: uniprot

uniprot Q01237 39
type: UnificationXref
id: Q01237
db: uniprot

Hydroxymethylglutaryl-CoA synthase, cytoplasmic
type: ProteinReference
xref: uniprot Q8JZK9 128
xref: PTHR43323:SF4
organism: Mus musculus

Diphosphomevalonate decarboxylase MVD1, peroxisomal
type: ProteinReference
xref: uniprot O23722 99
xref: PTHR10977:SF3
organism: Arabidopsis thaliana

PTHR43323:SF4
type: RelationshipXref
id: PTHR43323:SF4
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r22 184
type: Stoichiometry
physical entity: NADP+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 185
type: Stoichiometry
physical entity: Squalene
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 182
type: Stoichiometry
physical entity: Farsenyl pyrophosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 183
type: Stoichiometry
physical entity: NADPH + H+
stoichiometric coefficient: 1.0