Shikimate biosynthesis protein AroDE
type: ProteinReference
xref: uniprot O84375 81
organism: Chlamydia trachomatis

3-dehydroquinate synthase
type: ProteinReference
xref: uniprot O84374 64
organism: Chlamydia trachomatis

Chorismate synthase
type: ProteinReference
xref: uniprot O84373 6
organism: Chlamydia trachomatis

Shikimate kinase
type: ProteinReference
xref: uniprot O84372 95
organism: Chlamydia trachomatis

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot O84371 51
organism: Chlamydia trachomatis

Multifunctional fusion protein
type: ProteinReference
xref: uniprot Q7UQ72 85
organism: Rhodopirellula baltica

uniprot Q9RW91 45
type: UnificationXref
id: Q9RW91
db: uniprot

Chorismate synthase
type: ProteinReference
xref: uniprot Q8TT87 28
organism: Methanosarcina acetivorans

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot O67494 50
organism: Aquifex aeolicus

uniprot Q8RH64 43
type: UnificationXref
id: Q8RH64
db: uniprot

uniprot Q8F9N4 24
type: UnificationXref
id: Q8F9N4
db: uniprot

ncbitaxon 190304 27
type: UnificationXref
id: 190304
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__5_enolpyruvyl_shikimate_3_phosphate-RIGHT__chorismate-_PO4-_r7
controller: Chorismate synthase

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 19

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__shikimate_3_phosphate-_PEP-RIGHT__5_enolpyruvyl_shikimate_3_phosphate-_PO4-_r6
controller: 3-Phosphoshikimate-1-carboxyvinyl transferase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_shikimate-RIGHT__shikimate_3_phosphate-_ADP-_r5
controller: Shikimate kinase

uniprot P54517 40
type: UnificationXref
id: P54517
db: uniprot

Shikimate kinase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9SJ05 104
organism: Arabidopsis thaliana

uniprot Q8A2B2 99
type: UnificationXref
id: Q8A2B2
db: uniprot

Shikimate kinase
type: ProteinReference
xref: uniprot Q7UU71 98
organism: Rhodopirellula baltica

uniprot Q7NHU3 41
type: UnificationXref
id: Q7NHU3
db: uniprot

Shikimate dehydrogenase (NADP(+))
type: ProteinReference
xref: uniprot Q7NG95 84
organism: Gloeobacter violaceus

uniprot Q9WYI4 46
type: UnificationXref
id: Q9WYI4
db: uniprot

STATE_TRANSITION_LEFT__5_enolpyruvyl_shikimate_3_phosphate-RIGHT__chorismate-_PO4-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 118
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 117
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 116
left: 5-enolpyruvyl-shikimate-3-phosphate
interaction type: STATE_TRANSITION
right: chorismate
right: PO4

3-dehydroquinate dehydratase
type: ProteinReference
xref: uniprot Q8A3W2 42
organism: Bacteroides thetaiotaomicron

3-dehydroquinate dehydratase
type: ProteinReference
xref: uniprot P35146 39
organism: Bacillus subtilis

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 7

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 35

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot Q9RVD3 62
organism: Deinococcus radiodurans

uniprot P15474 38
type: UnificationXref
id: P15474
db: uniprot

Bifunctional 3-dehydroquinate synthase/phosphatase
type: ProteinReference
xref: uniprot Q8RF47 73
organism: Fusobacterium nucleatum

uniprot P35146 39
type: UnificationXref
id: P35146
db: uniprot

uniprot P37944 96
type: UnificationXref
id: P37944
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_erythrose_4_phophate-_PEP-RIGHT__3_deoxy_D_arabino_heptulosonate_7_phosphate-_PO4-_r1
controller: 2-Deoxy-7-phosphoheptulonate synthase

3-Dehydroquinate dehydratase
type: Protein
entity reference: 3-Dehydroquinate dehydratase
comment: SPECIES_TYPE=PROTEIN

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot Q8F6P5 56
organism: Leptospira interrogans

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 11

uniprot Q9P7R0 77
type: UnificationXref
id: Q9P7R0
db: uniprot

uniprot Q8EXX1 72
type: UnificationXref
id: Q8EXX1
db: uniprot

ncbitaxon 189518 25
type: UnificationXref
id: 189518
db: ncbitaxon

uniprot Q8THC3 88
type: UnificationXref
id: Q8THC3
db: uniprot

Chorismate synthase
type: ProteinReference
xref: uniprot O66493 2
organism: Aquifex aeolicus

uniprot Q9KXQ5 102
type: UnificationXref
id: Q9KXQ5
db: uniprot

Chorismate synthase
type: ProteinReference
xref: P02868
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Chorismate biosynthesis.PROTEIN.GENERIC.Chorismate synthase
comment: ENTITY_REFERENCE_NOTES= Long Name: Chorismate synthase Synonym: Synonym not specified Accession: P02868
member entity reference: Chorismate synthase
member entity reference: Chorismate synthase, chloroplastic

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9WYI3 79
type: UnificationXref
id: Q9WYI3
db: uniprot

Chorismate synthase
type: ProteinReference
xref: uniprot O74413 4
organism: Schizosaccharomyces pombe

ncbitaxon 367110 17
type: UnificationXref
id: 367110
db: ncbitaxon

3-dehydroquinate dehydratase
type: ProteinReference
xref: uniprot Q9WYI4 46
organism: Thermotoga maritima

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__3_dehydro_shikimate-_NADPH-RIGHT__NADP-_shikimate-_r4
controller: Shikimate dehydrogenase

Bifunctional shikimate kinase/3-dehydroquinate synthase
type: ProteinReference
xref: uniprot Q9WYI3 79
organism: Thermotoga maritima

Chorismate synthase
type: ProteinReference
xref: uniprot Q9WYI2 34
organism: Thermotoga maritima

uniprot O84375 81
type: UnificationXref
id: O84375
db: uniprot

PARTICIPANT STOICHIOMETRY r4 130
type: Stoichiometry
physical entity: shikimate
stoichiometric coefficient: 1.0

Shikimate dehydrogenase (NADP(+))
type: ProteinReference
xref: uniprot Q9WYI1 93
organism: Thermotoga maritima

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot Q9WYI0 63
organism: Thermotoga maritima

ncbitaxon 559292 11
type: UnificationXref
id: 559292
db: ncbitaxon

Chorismate synthase
type: ProteinReference
xref: uniprot P12008 8
organism: Escherichia coli

3-dehydroquinate dehydratase
type: ProteinReference
xref: uniprot Q7NHU3 41
organism: Gloeobacter violaceus

PARTICIPANT STOICHIOMETRY r5 124
type: Stoichiometry
physical entity: shikimate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 125
type: Stoichiometry
physical entity: shikimate-3-phosphate
stoichiometric coefficient: 1.0

3-dehydroquinate dehydratase
type: ProteinReference
xref: uniprot P05194 36
organism: Escherichia coli

PARTICIPANT STOICHIOMETRY r5 123
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Catabolic 3-dehydroquinase
type: ProteinReference
xref: uniprot P05195 37
organism: Neurospora crassa

PARTICIPANT STOICHIOMETRY r5 126
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q8REZ6 26
type: UnificationXref
id: Q8REZ6
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 17

5-enolpyruvyl-shikimate-3-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__shikimate_3_phosphate-_PEP-RIGHT__5_enolpyruvyl_shikimate_3_phosphate-_PO4-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 120
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 119
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 121
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 122
left: shikimate-3-phosphate
left: PEP
interaction type: STATE_TRANSITION
right: 5-enolpyruvyl-shikimate-3-phosphate
right: PO4

Chorismate synthase
type: ProteinReference
xref: uniprot Q8F9N4 24
organism: Leptospira interrogans

PARTICIPANT STOICHIOMETRY r4 129
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 128
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

uniprot Q9FVP6 59
type: UnificationXref
id: Q9FVP6
db: uniprot

Shikimate dehydrogenase (NADP(+))
type: ProteinReference
xref: uniprot P54374 83
organism: Bacillus subtilis

PARTICIPANT STOICHIOMETRY r4 127
type: Stoichiometry
physical entity: 3-dehydro-shikimate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_shikimate-RIGHT__shikimate_3_phosphate-_ADP-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 124
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 126
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 123
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 125
left: shikimate
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: shikimate-3-phosphate

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 23

3-dehydroquinate dehydratase
type: ProteinReference
xref: uniprot Q9RW91 45
organism: Deinococcus radiodurans

3-dehydroquinate synthase
type: ProteinReference
xref: uniprot Q9RW92 78
organism: Deinococcus radiodurans

Probable inactive shikimate kinase like 1, chloroplastic
type: ProteinReference
xref: uniprot Q9LW20 103
organism: Arabidopsis thaliana

uniprot P05194 36
type: UnificationXref
id: P05194
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 5

uniprot Q8GY88 100
type: UnificationXref
id: Q8GY88
db: uniprot

uniprot P05195 37
type: UnificationXref
id: P05195
db: uniprot

Chorismate synthase
type: ProteinReference
xref: uniprot Q9RW94 32
organism: Deinococcus radiodurans

uniprot Q7UW43 54
type: UnificationXref
id: Q7UW43
db: uniprot

PARTICIPANT STOICHIOMETRY r1 113
type: Stoichiometry
physical entity: PEP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 114
type: Stoichiometry
physical entity: 3-deoxy-D-arabino heptulosonate-7-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 111
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 112
type: Stoichiometry
physical entity: erythrose-4-phophate
stoichiometric coefficient: 1.0

uniprot Q7NLT3 53
type: UnificationXref
id: Q7NLT3
db: uniprot

uniprot Q9KXQ2 89
type: UnificationXref
id: Q9KXQ2
db: uniprot

uniprot P07639 65
type: UnificationXref
id: P07639
db: uniprot

uniprot P08566 66
type: UnificationXref
id: P08566
db: uniprot

PARTICIPANT STOICHIOMETRY r1 115
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 118
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

3-dehydroquinate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r7 117
type: Stoichiometry
physical entity: chorismate
stoichiometric coefficient: 1.0

Shikimate kinase
type: Protein
entity reference: Shikimate kinase
comment: SPECIES_TYPE=PROTEIN

uniprot Q8RF47 73
type: UnificationXref
id: Q8RF47
db: uniprot

uniprot Q9SQT8 92
type: UnificationXref
id: Q9SQT8
db: uniprot

uniprot P31102 67
type: UnificationXref
id: P31102
db: uniprot

PARTICIPANT STOICHIOMETRY r7 116
type: Stoichiometry
physical entity: 5-enolpyruvyl-shikimate-3-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 105
type: Stoichiometry
physical entity: 3-dehydroquinate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 106
type: Stoichiometry
physical entity: 3-dehydro-shikimate
stoichiometric coefficient: 1.0

uniprot O67049 80
type: UnificationXref
id: O67049
db: uniprot

PARTICIPANT STOICHIOMETRY r3 107
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Pentafunctional AROM polypeptide
type: ProteinReference
xref: uniprot P08566 66
organism: Saccharomyces cerevisiae

3-phosphoshikimate 1-carboxyvinyltransferase (Fragment)
type: ProteinReference
xref: uniprot A0A0N7KLH2 48
organism: Oryza sativa

uniprot Q7NH27 97
type: UnificationXref
id: Q7NH27
db: uniprot

uniprot Q9KXQ4 30
type: UnificationXref
id: Q9KXQ4
db: uniprot

Chorismate biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__ATP-_shikimate-RIGHT__shikimate_3_phosphate-_ADP-_r5
pathway component: STATE_TRANSITION_LEFT__3_dehydroquinate-RIGHT__3_dehydro_shikimate-_H2O-_r3
pathway component: STATE_TRANSITION_LEFT__3_deoxy_D_arabino_heptulosonate_7_phosphate-RIGHT__PO4-_3_dehydroquinate-_r2
pathway component: STATE_TRANSITION_LEFT__H2O-_erythrose_4_phophate-_PEP-RIGHT__3_deoxy_D_arabino_heptulosonate_7_phosphate-_PO4-_r1
pathway component: STATE_TRANSITION_LEFT__5_enolpyruvyl_shikimate_3_phosphate-RIGHT__chorismate-_PO4-_r7
pathway component: STATE_TRANSITION_LEFT__3_dehydro_shikimate-_NADPH-RIGHT__NADP-_shikimate-_r4
pathway component: STATE_TRANSITION_LEFT__shikimate_3_phosphate-_PEP-RIGHT__5_enolpyruvyl_shikimate_3_phosphate-_PO4-_r6
xref: PANTHER Pathway P02734 1
comment: MODEL_NOTES= The biosynthesis of chorismate, an important precursor to the biosynthesis of a number of aromatic compounds including the amino acids phenylalanine and tyrosine. Chorismate biosynthesis only occurs in bacteria, fungi, and plants. Website=www.biocyc.org/Ecoli/Pathways/ free text=Biochemistry (text) Voet and Voet

PARTICIPANT STOICHIOMETRY r6 120
type: Stoichiometry
physical entity: PEP
stoichiometric coefficient: 1.0

ncbitaxon 83333 9
type: UnificationXref
id: 83333
db: ncbitaxon

Pentafunctional AROM polypeptide
type: ProteinReference
xref: uniprot Q8X071 75
organism: Neurospora crassa

PARTICIPANT STOICHIOMETRY r6 121
type: Stoichiometry
physical entity: 5-enolpyruvyl-shikimate-3-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 122
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__3_dehydroquinate-RIGHT__3_dehydro_shikimate-_H2O-_r3
controller: 3-Dehydroquinate dehydratase

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 25

uniprot Q9KXQ6 76
type: UnificationXref
id: Q9KXQ6
db: uniprot

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 33

Shikimate kinase
type: ProteinReference
xref: uniprot P37944 96
organism: Bacillus subtilis

Chorismate synthase, chloroplastic
type: ProteinReference
xref: uniprot P57720 14
organism: Arabidopsis thaliana

uniprot Q9RVD3 62
type: UnificationXref
id: Q9RVD3
db: uniprot

uniprot Q8THC4 44
type: UnificationXref
id: Q8THC4
db: uniprot

3-dehydroquinate synthase
type: ProteinReference
xref: uniprot P31102 67
organism: Bacillus subtilis

uniprot P54374 83
type: UnificationXref
id: P54374
db: uniprot

3-dehydroquinate synthase
type: ProteinReference
xref: uniprot Q8A0P6 71
organism: Bacteroides thetaiotaomicron

ncbitaxon 251221 19
type: UnificationXref
id: 251221
db: ncbitaxon

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 15

3-dehydroquinate synthase
type: ProteinReference
xref: uniprot Q7UWN8 70
organism: Rhodopirellula baltica

chorismate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8A5Q2 55
type: UnificationXref
id: Q8A5Q2
db: uniprot

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__3_deoxy_D_arabino_heptulosonate_7_phosphate-RIGHT__PO4-_3_dehydroquinate-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 110
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 108
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 109
left: 3-deoxy-D-arabino heptulosonate-7-phosphate
interaction type: STATE_TRANSITION
right: 3-dehydroquinate
right: PO4

uniprot P12008 8
type: UnificationXref
id: P12008
db: uniprot

uniprot Q9RW94 32
type: UnificationXref
id: Q9RW94
db: uniprot

uniprot Q7RW62 69
type: UnificationXref
id: Q7RW62
db: uniprot

3-Phosphoshikimate-1-carboxyvinyl transferase
type: ProteinReference
xref: P02870
comment: ENTITY_REFERENCE_NOTES= Long Name: 3-Phosphoshikimate-1-carboxyvinyl transferase Synonym: Synonym not specified Accession: P02870
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Chorismate biosynthesis.PROTEIN.GENERIC.3-Phosphoshikimate-1-_br_carboxyvinyl transferase
member entity reference: 3-phosphoshikimate 1-carboxyvinyltransferase (Fragment)
member entity reference: 3-phosphoshikimate 1-carboxyvinyltransferase 1
member entity reference: 3-phosphoshikimate 1-carboxyvinyltransferase
member entity reference: 3-phosphoshikimate 1-carboxyvinyltransferase 2

PARTICIPANT STOICHIOMETRY r6 119
type: Stoichiometry
physical entity: shikimate-3-phosphate
stoichiometric coefficient: 1.0

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PANTHER Pathway P02734 1
type: UnificationXref
id: P02734
db: PANTHER Pathway

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 9

uniprot A0A0N7KLH2 48
type: UnificationXref
id: A0A0N7KLH2
db: uniprot

uniprot Q7NFY1 18
type: UnificationXref
id: Q7NFY1
db: uniprot

uniprot Q8F6P5 56
type: UnificationXref
id: Q8F6P5
db: uniprot

ncbitaxon 39947 49
type: UnificationXref
id: 39947
db: ncbitaxon

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot Q8THH3 58
organism: Methanosarcina acetivorans

Shikimate dehydrogenase
type: Protein
entity reference: Shikimate dehydrogenase
comment: SPECIES_TYPE=PROTEIN

3-Phosphoshikimate-1-carboxyvinyl transferase
type: Protein
entity reference: 3-Phosphoshikimate-1-carboxyvinyl transferase
comment: SPECIES_TYPE=PROTEIN

ACTIVE 47
type: EntityFeature
comment: Active state

Chorismate synthase
type: ProteinReference
xref: uniprot P31104 12
organism: Bacillus subtilis

uniprot Q9RW92 78
type: UnificationXref
id: Q9RW92
db: uniprot

STATE_TRANSITION_LEFT__3_dehydro_shikimate-_NADPH-RIGHT__NADP-_shikimate-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 128
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 127
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 129
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 130
left: 3-dehydro-shikimate
left: NADPH
interaction type: STATE_TRANSITION
right: shikimate
right: NADP

Chorismate synthase
type: ProteinReference
xref: uniprot Q7UPN5 20
organism: Rhodopirellula baltica

ncbitaxon 243090 21
type: UnificationXref
id: 243090
db: ncbitaxon

uniprot Q8A006 86
type: UnificationXref
id: Q8A006
db: uniprot

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot P20691 52
organism: Bacillus subtilis

Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic
type: ProteinReference
xref: uniprot Q9SQT8 92
organism: Arabidopsis thaliana

Shikimate kinase
type: ProteinReference
xref: P02874
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Chorismate biosynthesis.PROTEIN.GENERIC.Shikimate kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: Shikimate kinase Synonym: Synonym not specified Accession: P02874
member entity reference: Shikimate kinase 2, chloroplastic
member entity reference: Shikimate kinase 1, chloroplastic
member entity reference: Probable inactive shikimate kinase like 1, chloroplastic
member entity reference: Shikimate kinase

Shikimate 5-dehydrogenase
type: ProteinReference
xref: uniprot Q8A006 86
organism: Bacteroides thetaiotaomicron

Shikimate kinase
type: ProteinReference
xref: uniprot O67925 94
organism: Aquifex aeolicus

ncbitaxon 224308 13
type: UnificationXref
id: 224308
db: ncbitaxon

ncbitaxon 100226 31
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot Q7UWN8 70
type: UnificationXref
id: Q7UWN8
db: uniprot

uniprot O84372 95
type: UnificationXref
id: O84372
db: uniprot

3-Dehydroquinate synthase
type: ProteinReference
xref: P02872
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: 3-Dehydroquinate synthase Synonym: Synonym not specified Accession: P02872
comment: ENTITY_REFERENCE_ID_DESC=Chorismate biosynthesis.PROTEIN.GENERIC.3-Dehydroquinate_br_synthase
member entity reference: 3-dehydroquinate synthase
member entity reference: Repressor protein
member entity reference: Pentafunctional AROM polypeptide
member entity reference: Bifunctional shikimate kinase/3-dehydroquinate synthase
member entity reference: Bifunctional 3-dehydroquinate synthase/phosphatase
member entity reference: 3-dehydroquinate synthase, chloroplastic

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 13

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 27

uniprot Q7UPN5 20
type: UnificationXref
id: Q7UPN5
db: uniprot

Chorismate synthase
type: ProteinReference
xref: uniprot Q9KXQ4 30
organism: Streptomyces coelicolor

uniprot Q8A602 22
type: UnificationXref
id: Q8A602
db: uniprot

3-dehydroquinate synthase
type: ProteinReference
xref: uniprot Q9KXQ6 76
organism: Streptomyces coelicolor

Shikimate kinase
type: ProteinReference
xref: uniprot Q9KXQ5 102
organism: Streptomyces coelicolor

uniprot Q8TT87 28
type: UnificationXref
id: Q8TT87
db: uniprot

Shikimate 5-dehydrogenase
type: ProteinReference
xref: uniprot Q9KXQ2 89
organism: Streptomyces coelicolor

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot Q9FVP6 59
organism: Arabidopsis thaliana

uniprot P31104 12
type: UnificationXref
id: P31104
db: uniprot

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P15770 82
type: UnificationXref
id: P15770
db: uniprot

uniprot Q8RF94 101
type: UnificationXref
id: Q8RF94
db: uniprot

PARTICIPANT STOICHIOMETRY r2 109
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

Shikimate 5-dehydrogenase, putative
type: ProteinReference
xref: uniprot Q9RY73 91
organism: Deinococcus radiodurans

PARTICIPANT STOICHIOMETRY r2 108
type: Stoichiometry
physical entity: 3-deoxy-D-arabino heptulosonate-7-phosphate
stoichiometric coefficient: 1.0

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 29

uniprot Q8A3W2 42
type: UnificationXref
id: Q8A3W2
db: uniprot

ncbitaxon 243230 33
type: UnificationXref
id: 243230
db: ncbitaxon

uniprot Q8F8C0 87
type: UnificationXref
id: Q8F8C0
db: uniprot

PEP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 188937 29
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot O74413 4
type: UnificationXref
id: O74413
db: uniprot

ncbitaxon 272561 7
type: UnificationXref
id: 272561
db: ncbitaxon

uniprot Q9WYI1 93
type: UnificationXref
id: Q9WYI1
db: uniprot

3-dehydroquinate dehydratase
type: ProteinReference
xref: uniprot Q8THC4 44
organism: Methanosarcina acetivorans

uniprot P20691 52
type: UnificationXref
id: P20691
db: uniprot

Shikimate dehydrogenase (NADP(+))
type: ProteinReference
xref: uniprot Q8THC3 88
organism: Methanosarcina acetivorans

uniprot Q9K4A7 60
type: UnificationXref
id: Q9K4A7
db: uniprot

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 3

3-dehydroquinate synthase
type: ProteinReference
xref: uniprot Q7NHM2 68
organism: Gloeobacter violaceus

uniprot O67494 50
type: UnificationXref
id: O67494
db: uniprot

Shikimate kinase
type: ProteinReference
xref: uniprot Q8A2B2 99
organism: Bacteroides thetaiotaomicron

uniprot P28777 10
type: UnificationXref
id: P28777
db: uniprot

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O84373 6
type: UnificationXref
id: O84373
db: uniprot

ncbitaxon 3702 15
type: UnificationXref
id: 3702
db: ncbitaxon

STATE_TRANSITION_LEFT__H2O-_erythrose_4_phophate-_PEP-RIGHT__3_deoxy_D_arabino_heptulosonate_7_phosphate-_PO4-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 115
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 111
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 112
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 113
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 114
left: erythrose-4-phophate
left: PEP
left: H2O
interaction type: STATE_TRANSITION
right: 3-deoxy-D-arabino heptulosonate-7-phosphate
right: PO4

PARTICIPANT STOICHIOMETRY r2 110
type: Stoichiometry
physical entity: 3-dehydroquinate
stoichiometric coefficient: 1.0

shikimate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q12640 16
type: UnificationXref
id: Q12640
db: uniprot

uniprot Q7NHM2 68
type: UnificationXref
id: Q7NHM2
db: uniprot

ncbitaxon 226186 23
type: UnificationXref
id: 226186
db: ncbitaxon

uniprot Q9LW20 103
type: UnificationXref
id: Q9LW20
db: uniprot

ncbitaxon 284812 5
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q7UQ72 85
type: UnificationXref
id: Q7UQ72
db: uniprot

Shikimate dehydrogenase (NADP(+))
type: ProteinReference
xref: uniprot Q8F8C0 87
organism: Leptospira interrogans

3-dehydroquinate synthase
type: ProteinReference
xref: uniprot Q8EXX1 72
organism: Leptospira interrogans

3-dehydroquinate dehydratase
type: ProteinReference
xref: uniprot Q8RH64 43
organism: Fusobacterium nucleatum

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 21

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 31

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q9WYI2 34
type: UnificationXref
id: Q9WYI2
db: uniprot

Chorismate synthase
type: ProteinReference
xref: uniprot P28777 10
organism: Saccharomyces cerevisiae

Repressor protein
type: ProteinReference
xref: uniprot Q7RW62 69
organism: Neurospora crassa

uniprot Q8A0P6 71
type: UnificationXref
id: Q8A0P6
db: uniprot

3-Dehydroquinate synthase
type: Protein
entity reference: 3-Dehydroquinate synthase
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__3_deoxy_D_arabino_heptulosonate_7_phosphate-RIGHT__PO4-_3_dehydroquinate-_r2
controller: 3-Dehydroquinate synthase

3-dehydroquinate dehydratase
type: ProteinReference
xref: uniprot P15474 38
organism: Streptomyces coelicolor

uniprot Q8THH3 58
type: UnificationXref
id: Q8THH3
db: uniprot

3-phosphoshikimate 1-carboxyvinyltransferase 1
type: ProteinReference
xref: uniprot Q9K4A7 60
organism: Streptomyces coelicolor

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot Q8REZ7 57
organism: Fusobacterium nucleatum

uniprot O84374 64
type: UnificationXref
id: O84374
db: uniprot

uniprot Q9RV57 90
type: UnificationXref
id: Q9RV57
db: uniprot

ncbitaxon 243274 35
type: UnificationXref
id: 243274
db: ncbitaxon

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot Q8A5Q2 55
organism: Bacteroides thetaiotaomicron

3-dehydroquinate dehydratase
type: ProteinReference
xref: uniprot P54517 40
organism: Bacillus subtilis

uniprot Q7UU71 98
type: UnificationXref
id: Q7UU71
db: uniprot

3-dehydro-shikimate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P57720 14
type: UnificationXref
id: P57720
db: uniprot

Chorismate synthase
type: ProteinReference
xref: uniprot Q8REZ6 26
organism: Fusobacterium nucleatum

Pentafunctional AROM polypeptide
type: ProteinReference
xref: uniprot Q9P7R0 77
organism: Schizosaccharomyces pombe

uniprot Q7NG95 84
type: UnificationXref
id: Q7NG95
db: uniprot

uniprot Q9RY73 91
type: UnificationXref
id: Q9RY73
db: uniprot

Shikimate dehydrogenase (NADP(+))
type: ProteinReference
xref: uniprot Q9RV57 90
organism: Deinococcus radiodurans

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot Q7UW43 54
organism: Rhodopirellula baltica

uniprot Q9L213 61
type: UnificationXref
id: Q9L213
db: uniprot

Shikimate kinase 2, chloroplastic
type: ProteinReference
xref: uniprot Q8GY88 100
organism: Arabidopsis thaliana

Shikimate dehydrogenase
type: ProteinReference
xref: P02873
comment: ENTITY_REFERENCE_ID_DESC=Chorismate biosynthesis.PROTEIN.GENERIC.Shikimate_br_dehydrogenase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Shikimate dehydrogenase Synonym: Synonym not specified Accession: P02873
member entity reference: Shikimate dehydrogenase (NADP(+))
member entity reference: Shikimate 5-dehydrogenase
member entity reference: Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic
member entity reference: Shikimate biosynthesis protein AroDE
member entity reference: Shikimate 5-dehydrogenase, putative
member entity reference: Multifunctional fusion protein

Chorismate synthase
type: ProteinReference
xref: uniprot Q7NFY1 18
organism: Gloeobacter violaceus

shikimate-3-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9WYI0 63
type: UnificationXref
id: Q9WYI0
db: uniprot

Shikimate dehydrogenase (NADP(+))
type: ProteinReference
xref: uniprot O67049 80
organism: Aquifex aeolicus

uniprot Q9SJ05 104
type: UnificationXref
id: Q9SJ05
db: uniprot

3-dehydroquinate synthase
type: ProteinReference
xref: uniprot P07639 65
organism: Escherichia coli

uniprot O66493 2
type: UnificationXref
id: O66493
db: uniprot

Shikimate dehydrogenase (NADP(+))
type: ProteinReference
xref: uniprot P15770 82
organism: Escherichia coli

Chorismate synthase
type: Protein
entity reference: Chorismate synthase
comment: SPECIES_TYPE=PROTEIN

3-Dehydroquinate dehydratase
type: ProteinReference
xref: P02869
standard name: 3-dehydroquinate dehydratase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Chorismate biosynthesis.PROTEIN.GENERIC.3-Dehydroquinate_br_dehydratase
comment: ENTITY_REFERENCE_NOTES= Long Name: 3-dehydroquinate dehydratase Synonym: Synonym not specified Accession: P02869
member entity reference: 3-dehydroquinate dehydratase
member entity reference: Catabolic 3-dehydroquinase

ncbitaxon 224324 3
type: UnificationXref
id: 224324
db: ncbitaxon

P02869
type: UnificationXref
id: P02869
db: PANTHER Pathway Component

P02868
type: UnificationXref
id: P02868
db: PANTHER Pathway Component

uniprot O84371 51
type: UnificationXref
id: O84371
db: uniprot

uniprot O67925 94
type: UnificationXref
id: O67925
db: uniprot

Shikimate kinase
type: ProteinReference
xref: uniprot Q7NH27 97
organism: Gloeobacter violaceus

Chorismate synthase
type: ProteinReference
xref: uniprot Q8A602 22
organism: Bacteroides thetaiotaomicron

uniprot Q8VYV7 74
type: UnificationXref
id: Q8VYV7
db: uniprot

3-deoxy-D-arabino heptulosonate-7-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8X071 75
type: UnificationXref
id: Q8X071
db: uniprot

2-Deoxy-7-phosphoheptulonate synthase
type: Protein
feature: ACTIVE 47
comment: SPECIES_TYPE=PROTEIN

erythrose-4-phophate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

3-phosphoshikimate 1-carboxyvinyltransferase 2
type: ProteinReference
xref: uniprot Q9L213 61
organism: Streptomyces coelicolor

3-dehydroquinate synthase, chloroplastic
type: ProteinReference
xref: uniprot Q8VYV7 74
organism: Arabidopsis thaliana

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 49

P02873
type: UnificationXref
id: P02873
db: PANTHER Pathway Component

P02874
type: UnificationXref
id: P02874
db: PANTHER Pathway Component

uniprot Q8REZ7 57
type: UnificationXref
id: Q8REZ7
db: uniprot

P02872
type: UnificationXref
id: P02872
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__3_dehydroquinate-RIGHT__3_dehydro_shikimate-_H2O-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 107
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 106
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 105
left: 3-dehydroquinate
interaction type: STATE_TRANSITION
right: 3-dehydro-shikimate
right: H2O

Chorismate synthase
type: ProteinReference
xref: uniprot Q12640 16
organism: Neurospora crassa

Shikimate kinase
type: ProteinReference
xref: uniprot Q8RF94 101
organism: Fusobacterium nucleatum

P02870
type: UnificationXref
id: P02870
db: PANTHER Pathway Component

3-phosphoshikimate 1-carboxyvinyltransferase
type: ProteinReference
xref: uniprot Q7NLT3 53
organism: Gloeobacter violaceus