uniprot F6ZYJ9 20
type: UnificationXref
id: F6ZYJ9
db: uniprot

Complex (BMAL1/Clock)
type: Complex
component stoichiometry: Clock s57 sa41 STOICHIOMETRY ID COMPLEX
component stoichiometry: BMAL1 s56 sa40 STOICHIOMETRY ID COMPLEX
component: BMAL1
component: Clock
feature: COMPLEX BINDING FEATURE s37 csa6 136
feature: COMPLEX BINDING FEATURE s37 csa6 138
cellular location: nucleus

PER1 isoform 1
type: ProteinReference
xref: PTHR11269:SF8
xref: uniprot K7CRG5 61
organism: Pan troglodytes

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 2

Circadian clock system
type: Pathway
pathway component: TRANSCRIPTION_LEFT__per-RIGHT__per-_r43
pathway component: TRANSCRIPTION_LEFT__rev_erb-RIGHT__rev_erb-_r44
pathway component: TRANSCRIPTION_LEFT__bmal1-RIGHT__bmal1-_r46
pathway component: TRANSLATION_LEFT__cry-RIGHT__Cry-_r53
pathway component: STATE_TRANSITION_LEFT__ATP-_Complex__Casein_kinase_I_Per_-RIGHT__ADP-_Complex__Per_Casein_kinase_I_-_r11
pathway component: TRANSLATION_LEFT__rev_erb-RIGHT__Rev_erb-_r52
pathway component: STATE_TRANSITION_LEFT__Per-RIGHT__a20_degraded-_r6
pathway component: TRANSPORT_LEFT__cry-RIGHT__cry-_r51
pathway component: STATE_TRANSITION_LEFT__Per-RIGHT__Per-_r1
pathway component: TRANSPORT_LEFT__bmal1-RIGHT__bmal1-_r50
pathway component: TRANSLATION_LEFT__per-RIGHT__Per-_r48
pathway component: TRANSPORT_LEFT__per-RIGHT__per-_r47
pathway component: TRANSCRIPTION_LEFT__cry-RIGHT__cry-_r45
pathway component: TRANSLATION_LEFT__bmal1-RIGHT__BMAL1-_r54
pathway component: TRANSPORT_LEFT__Rev_erb-RIGHT__Rev_erb-_r38
pathway component: DISSOCIATION_LEFT__Complex__Per_Casein_kinase_I_-RIGHT__Per-_Casein_kinase_I-_r13
pathway component: HETERODIMER_ASSOCIATION_LEFT__Per-_Casein_kinase_I-RIGHT__Complex__Casein_kinase_I_Per_-_r8
pathway component: TRANSPORT_LEFT__rev_erb-RIGHT__rev_erb-_r49
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Per_Casein_kinase_I_-_Cry-RIGHT__Complex__Per_Cry__Casein_kinase_I_-_r15
pathway component: TRANSPORT_LEFT__Complex__Per_Cry__Casein_kinase_I_-RIGHT__Complex__Per_Cry__Casein_kinase_I_-_r17
pathway component: STATE_TRANSITION_LEFT__Complex__BMAL1_Clock_-RIGHT__Complex__BMAL1_Clock_-_re28
pathway component: HETERODIMER_ASSOCIATION_LEFT__BMAL1-_Clock-RIGHT__Complex__BMAL1_Clock_-_r18
pathway component: TRANSPORT_LEFT__BMAL1-RIGHT__BMAL1-_r36
xref: PANTHER Pathway P00015 1
comment: MODEL_NOTES=Panther Pathway: P00015 This is the current model of the molecular circadian pacemaker. In mammals, the core circadian pacemaker is found in the neurons of the suprachiasmatic nucleus. This pacemaker can synchronize peripheral clocks located throughout the animal to the rhythm of the core pacemaker. Note that the fluctuation of both protein and mRNA levels of many components of the clock are important for normal periodicity. There are important threshhold levels which proteins and mRNAs much reach before the next step of the pathway can proceed. This gives the pacemaker the ability to "free run" in the absence of external cues with a period of approximately 24 hours. Medline=12198538 Medline=12446131 Medline=12724733 PMID: 12198538 PMID: 12446131 PMID: 12724733

Uncharacterized protein
type: DnaReference
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR11269:SF13
xref: uniprot A0A1D5R421 52
organism: Macaca mulatta

Casein kinase 1 epsilon
type: ProteinReference
xref: uniprot Q5XGI6 44
xref: PTHR11909:SF18
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_Complex__Casein_kinase_I_Per_-RIGHT__ADP-_Complex__Per_Casein_kinase_I_-_r11
controller: Casein kinase I

ncbitaxon 9615 7
type: UnificationXref
id: 9615
db: ncbitaxon

Casein kinase I s6 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Casein kinase I
stoichiometric coefficient: 1.0

Complex (Casein kinase I/Per)
type: Complex
component stoichiometry: Per s8 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Casein kinase I s7 sa4 STOICHIOMETRY ID COMPLEX
component: Per
component: Casein kinase I
feature: COMPLEX BINDING FEATURE s20 a25 142
feature: COMPLEX BINDING FEATURE s20 a25 140
cellular location: Pacemaker Neuron c1

Casein kinase I
type: Protein
entity reference: Casein kinase I
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa4 141
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

Clock
type: Protein
entity reference: Clock
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa41 139
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Cryptochrome circadian regulator 1
type: DnaReference
organism: Xenopus tropicalis

uniprot Q9R194 105
type: UnificationXref
id: Q9R194
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 13

Aryl hydrocarbon receptor nuclear translocator-like protein 1
type: DnaReference
xref: PTHR23042:SF52
organism: Gallus gallus

Period circadian protein homolog 1
type: ProteinReference
xref: uniprot O35973 64
xref: PTHR11269:SF8
organism: Mus musculus

Period circadian protein homolog 1
type: ProteinReference
xref: uniprot Q8CHI5 69
xref: PTHR11269:SF8
organism: Rattus norvegicus

Period circadian protein homolog 2
type: ProteinReference
xref: uniprot O54943 65
organism: Mus musculus

Per
type: Protein
entity reference: Per
feature: ACTIVE 73
feature: Per s1 a16 rs1
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

uniprot Q6P647 46
type: UnificationXref
id: Q6P647
db: uniprot

PARTICIPANT STOICHIOMETRY r36 151
type: Stoichiometry
physical entity: BMAL1
stoichiometric coefficient: 1.0

uniprot O35973 64
type: UnificationXref
id: O35973
db: uniprot

Casein kinase 1 delta
type: ProteinReference
xref: uniprot F1Q126 34
xref: PTHR11909:SF378
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r36 150
type: Stoichiometry
physical entity: BMAL1
stoichiometric coefficient: 1.0

uniprot F1R1X1 87
type: UnificationXref
id: F1R1X1
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 14

ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

PTHR11269:SF8
type: RelationshipXref
id: PTHR11269:SF8
db: PANTHER Family
relationship type: By Homology

PTHR11269:SF9
type: RelationshipXref
id: PTHR11269:SF9
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r49 156
type: Stoichiometry
physical entity: rev-erb
stoichiometric coefficient: 1.0

Period circadian protein homolog 2
type: DnaReference
organism: Mus musculus

uniprot O08785 26
type: UnificationXref
id: O08785
db: uniprot

PARTICIPANT STOICHIOMETRY r49 155
type: Stoichiometry
physical entity: rev-erb
stoichiometric coefficient: 1.0

uniprot F7BWW8 90
type: UnificationXref
id: F7BWW8
db: uniprot

GO GO:0005634 2
type: UnificationXref
id: GO:0005634
db: GO

Casein kinase I isoform delta
type: ProteinReference
xref: uniprot Q6P647 46
xref: PTHR11909:SF378
organism: Xenopus tropicalis

eco ECO:0000270 16
type: UnificationXref
id: ECO:0000270
db: eco

uniprot O70361 66
type: UnificationXref
id: O70361
db: uniprot

G01500
type: UnificationXref
id: G01500
db: PANTHER Pathway Component

G01501
type: UnificationXref
id: G01501
db: PANTHER Pathway Component

ncbitaxon 8364 21
type: UnificationXref
id: 8364
db: ncbitaxon

Period circadian protein homolog 3
type: ProteinReference
xref: PTHR11269:SF13
xref: uniprot P56645 68
organism: Homo sapiens

Period circadian protein
type: ProteinReference
xref: uniprot P07663 67
xref: PTHR11269:SF16
organism: Drosophila melanogaster

Casein kinase I
type: Protein
entity reference: Casein kinase I
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

uniprot F6R2T7 35
type: UnificationXref
id: F6R2T7
db: uniprot

BMAL1
type: Protein
entity reference: BMAL1
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa11 133
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

BMAL1
type: Protein
entity reference: BMAL1
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa40 137
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r6 168
type: Stoichiometry
physical entity: a20_degraded
stoichiometric coefficient: 1.0

uniprot G7NDW2 108
type: UnificationXref
id: G7NDW2
db: uniprot

PARTICIPANT STOICHIOMETRY r6 167
type: Stoichiometry
physical entity: Per
stoichiometric coefficient: 1.0

Period circadian clock 1b
type: ProteinReference
xref: uniprot B3DK47 53
xref: PTHR11269:SF8
organism: Danio rerio

Cryptochrome-1
type: ProteinReference
xref: uniprot P97784 94
xref: PTHR11455:SF16
organism: Mus musculus

Period circadian protein homolog 3
type: DnaReference
xref: PTHR11269:SF13
organism: Mus musculus

Cryptochrome-1
type: ProteinReference
xref: uniprot O77059 93
xref: PTHR11455:SF17
organism: Drosophila melanogaster

TRANSLATION
type: RelationshipTypeVocabulary

uniprot Q5XGI6 44
type: UnificationXref
id: Q5XGI6
db: uniprot

ncbitaxon 13616 23
type: UnificationXref
id: 13616
db: ncbitaxon

TRANSPORT_LEFT__BMAL1-RIGHT__BMAL1-_r36
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 150
left: BMAL1
interaction type: TRANSPORT
right: BMAL1

Period circadian protein homolog 3
type: DnaReference
xref: PTHR11269:SF13
organism: Homo sapiens

Period circadian protein homolog 2
type: DnaReference
xref: PTHR11269:SF9
organism: Homo sapiens

Per
type: Protein
entity reference: Per
feature: Per s14 a20 rs1
feature: ACTIVE 73
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

Period circadian protein homolog 1
type: DnaReference
xref: PTHR11269:SF8
organism: Homo sapiens

cry
type: RnaRegion
entity reference: cry
cellular location: nucleus
comment: SPECIES_TYPE=RNA

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

uniprot F1QUT1 57
type: UnificationXref
id: F1QUT1
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 21

uniprot P35508 40
type: UnificationXref
id: P35508
db: uniprot

Per s12 sa8 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q16526 95
type: UnificationXref
id: Q16526
db: uniprot

Cry
type: Protein
entity reference: Cry
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r11 176
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Cryptochrome-2
type: DnaReference
xref: PTHR11455:SF15
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r11 177
type: Stoichiometry
physical entity: Complex (Per/Casein kinase I)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 174
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 175
type: Stoichiometry
physical entity: Complex (Casein kinase I/Per)
stoichiometric coefficient: 1.0

Aryl hydrocarbon receptor nuclear translocator-like protein 1
type: DnaReference
xref: PTHR23042:SF52
organism: Homo sapiens

uniprot F6X852 88
type: UnificationXref
id: F6X852
db: uniprot

TRANSLATION_LEFT__per-RIGHT__Per-_r48
type: TemplateReaction
product: Per
xref: TRANSLATION
participant: Per
participant: per
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot Q43125 97
type: UnificationXref
id: Q43125
db: uniprot

uniprot F1PSD8 19
type: UnificationXref
id: F1PSD8
db: uniprot

per
type: RnaRegion
entity reference: per
cellular location: nucleus
comment: SPECIES_TYPE=RNA

uniprot B3DH92 17
type: UnificationXref
id: B3DH92
db: uniprot

uniprot H2Q6S7 92
type: UnificationXref
id: H2Q6S7
db: uniprot

ncbitaxon 10116 15
type: UnificationXref
id: 10116
db: ncbitaxon

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__cry-RIGHT__cry-_r45
control type: INHIBITION
controller: Rev-erb

Cryptochrome circadian regulator 2
type: DnaReference
xref: PTHR11455:SF15
organism: Bos taurus

uniprot Q5RIV1 28
type: UnificationXref
id: Q5RIV1
db: uniprot

CLOCK isoform 1
type: ProteinReference
xref: uniprot H2QPH9 24
xref: PTHR46055:SF2
organism: Pan troglodytes

uniprot F7DL74 22
type: UnificationXref
id: F7DL74
db: uniprot

Per s8 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Per
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_Complex__Casein_kinase_I_Per_-RIGHT__ADP-_Complex__Per_Casein_kinase_I_-_r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 177
left: Complex (Casein kinase I/Per)
left: ATP
interaction type: STATE_TRANSITION
right: Complex (Per/Casein kinase I)
right: ADP

uniprot E1C8E2 54
type: UnificationXref
id: E1C8E2
db: uniprot

TRANSPORT_LEFT__rev_erb-RIGHT__rev_erb-_r49
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY r49 155
left: rev-erb
interaction type: TRANSPORT
right: rev-erb

bmal1
type: RnaRegion
entity reference: bmal1
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=RNA

uniprot E1BLF5 107
type: UnificationXref
id: E1BLF5
db: uniprot

a20_degraded
type: PhysicalEntity
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=DEGRADED

uniprot Q9Z301 72
type: UnificationXref
id: Q9Z301
db: uniprot

Casein kinase I
type: ProteinReference
xref: P00502
standard name: Casine kinase I
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.PROTEIN.GENERIC.Casein_space_kinase_space_I
comment: ENTITY_REFERENCE_NOTES=Long Name: Casine kinase I Synonym: CKI,Doubletime,dbt Accession: P00502
member entity reference: Casein kinase 1 delta
member entity reference: Uncharacterized protein
member entity reference: Casein kinase I isoform epsilon
member entity reference: Casein kinase 1, epsilon
member entity reference: Casein kinase I isoform delta
member entity reference: Casein kinase 1 epsilon
member entity reference: Casein kinase I isoform delta-A
member entity reference: Casein kinase I isoform delta-B
member entity reference: CSNK1D isoform 8
member entity reference: Discs overgrown protein kinase

ncbitaxon 9544 3
type: UnificationXref
id: 9544
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR23042:SF52
xref: uniprot E1BLF5 107
organism: Bos taurus

Cryptochrome-1
type: DnaReference
organism: Gallus gallus

Cryptochrome-2
type: DnaReference
organism: Gallus gallus

Period circadian protein homolog 2
type: ProteinReference
xref: uniprot Q9Z301 72
organism: Rattus norvegicus

ACTIVE 73
type: EntityFeature
comment: Active state

Cryptochrome circadian regulator 1bb
type: ProteinReference
xref: uniprot A0A2R8QLW6 79
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r15 166
type: Stoichiometry
physical entity: Complex (Per/Cry/ Casein kinase I)
stoichiometric coefficient: 1.0

CRY2 isoform 1
type: DnaReference
xref: PTHR11455:SF15
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r15 165
type: Stoichiometry
physical entity: Cry
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 164
type: Stoichiometry
physical entity: Complex (Per/Casein kinase I)
stoichiometric coefficient: 1.0

Period circadian protein homolog 2
type: ProteinReference
xref: PTHR11269:SF9
xref: uniprot O15055 62
organism: Homo sapiens

Period circadian regulator 1
type: DnaReference
xref: PTHR11269:SF8
organism: Canis lupus familiaris

Brain and Muscle Arnt-Like 1
type: DnaRegionReference
member entity reference: Protein cycle
member entity reference: Uncharacterized protein
member entity reference: Aryl hydrocarbon receptor nuclear translocator-like protein 1
member entity reference: Aryl hydrocarbon receptor nuclear translocator-like 1a
member entity reference: Aryl hydrocarbon receptor nuclear translocator like
member entity reference: Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a
xref: G01500
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.GENE.GENE.bmal1
comment: ENTITY_REFERENCE_NOTES=Long Name: Brain and Muscle Arnt-Like 1 Synonym: MOP3 Accession: G01500
display name: bmal1

Cryptochrome circadian regulator 1ab
type: DnaReference
organism: Danio rerio

Cryptochrome circadian regulator 1bb
type: DnaReference
organism: Danio rerio

Cryptochrome circadian regulator 1ba
type: DnaReference
organism: Danio rerio

Cry
type: Protein
entity reference: Cry
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa2 119
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0P0WAS3 76
type: UnificationXref
id: A0A0P0WAS3
db: uniprot

Per
type: Protein
entity reference: Per
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 117
feature: Per s3 sa1 rs1
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

Aryl hydrocarbon receptor nuclear translocator like
type: ProteinReference
xref: PTHR23042:SF52
xref: uniprot J9NTT7 109
organism: Canis lupus familiaris

Cryptochrome circadian regulator 5
type: DnaReference
organism: Danio rerio

uniprot H2QPH9 24
type: UnificationXref
id: H2QPH9
db: uniprot

per
type: DnaRegion
entity reference: Period
cellular location: nucleus
comment: SPECIES_TYPE=GENE

Per s10 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Per
stoichiometric coefficient: 1.0

Period circadian protein homolog 3
type: ProteinReference
xref: PTHR11269:SF13
xref: uniprot O70361 66
organism: Mus musculus

Cryptochrome circadian regulator 1
type: DnaReference
xref: PTHR11455:SF16
organism: Canis lupus familiaris

Cryptochrome circadian regulator 1
type: DnaReference
xref: PTHR11455:SF16
organism: Monodelphis domestica

TRANSPORT_LEFT__Rev_erb-RIGHT__Rev_erb-_r38
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 148
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 149
left: Rev-erb
interaction type: TRANSPORT
right: Rev-erb

Cryptochrome circadian regulator 2
type: ProteinReference
xref: PTHR11455:SF15
xref: uniprot F6X852 88
organism: Ornithorhynchus anatinus

ncbitaxon 7227 14
type: UnificationXref
id: 7227
db: ncbitaxon

TRANSLATION_LEFT__rev_erb-RIGHT__Rev_erb-_r52
type: TemplateReaction
product: Rev-erb
xref: TRANSLATION
participant: rev-erb
participant: Rev-erb
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

CRY1 protein
type: DnaReference
xref: PTHR11455:SF16
organism: Bos taurus

Cryptochrome-1
type: DnaReference
xref: PTHR11455:SF16
organism: Macaca mulatta

uniprot Q8CHI5 69
type: UnificationXref
id: Q8CHI5
db: uniprot

Cryptochrome circadian regulator 1
type: ProteinReference
xref: uniprot F7BWW8 90
xref: PTHR11455:SF16
organism: Monodelphis domestica

DISSOCIATION_LEFT__Complex__Per_Casein_kinase_I_-RIGHT__Per-_Casein_kinase_I-_r13
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 170
left: Complex (Per/Casein kinase I)
interaction type: DISSOCIATION
right: Per
right: Casein kinase I

uniprot E2RMX4 83
type: UnificationXref
id: E2RMX4
db: uniprot

Aryl hydrocarbon receptor nuclear translocator-like 1a
type: ProteinReference
xref: uniprot Q9I879 113
organism: Danio rerio

Bos taurus
type: BioSource
xref: ncbitaxon 9913 8

Cryptochrome-2
type: ProteinReference
xref: PTHR11455:SF15
xref: uniprot Q49AN0 98
organism: Homo sapiens

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 3

00696
type: UnificationXref
id: MOD:00696
db: mod

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__bmal1-RIGHT__bmal1-_r46
control type: ACTIVATION
controller: Complex (BMAL1/Clock)

Cryptochrome circadian regulator 2
type: DnaReference
xref: PTHR11455:SF15
organism: Ornithorhynchus anatinus

TRANSLATION
type: InteractionVocabulary

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 37

Casein kinase I isoform epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot P49674 42
organism: Homo sapiens

Discs overgrown protein kinase
type: ProteinReference
xref: uniprot O76324 39
xref: PTHR11909:SF18
organism: Drosophila melanogaster

TRANSCRIPTION_LEFT__bmal1-RIGHT__bmal1-_r46
type: TemplateReaction
product: bmal1
xref: TRANSCRIPTION
participant: bmal1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Rev-erb
type: Protein
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

uniprot O54943 65
type: UnificationXref
id: O54943
db: uniprot

Cryptochrome circadian regulator 1
type: ProteinReference
xref: uniprot F6X865 89
organism: Xenopus tropicalis

ncbitaxon 10090 13
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot O15055 62
type: UnificationXref
id: O15055
db: uniprot

Blue-light photoreceptor PHR2
type: ProteinReference
xref: uniprot Q8LB72 100
organism: Arabidopsis thaliana

Complex (Per/Cry/ Casein kinase I)
type: Complex
component stoichiometry: Casein kinase I s6 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Per s3 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cry s5 sa2 STOICHIOMETRY ID COMPLEX
component: Casein kinase I
component: Cry
component: Per
feature: COMPLEX BINDING FEATURE s9 a13 116
feature: COMPLEX BINDING FEATURE s9 a13 120
feature: COMPLEX BINDING FEATURE s9 a13 118
cellular location: Pacemaker Neuron c1

BMAL1
type: Protein
entity reference: BMAL1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot A0A1D5Q816 77
type: UnificationXref
id: A0A1D5Q816
db: uniprot

uniprot O15534 63
type: UnificationXref
id: O15534
db: uniprot

Period circadian regulator 1
type: ProteinReference
xref: PTHR11269:SF8
xref: uniprot E2R0I6 55
organism: Canis lupus familiaris

per
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.RNA.RNA.per
comment: ENTITY_REFERENCE_NOTES=Long Name: per Synonym: Per1,Per2,Per3,Period,Period1,Period2,Period3,hPer1,hPer2,hPer3,mPer1,mPer2,mPer3 Accession: G01503

Casein kinase I isoform epsilon
type: ProteinReference
xref: uniprot F6R2T7 35
xref: PTHR11909:SF18
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot Q99PS2 48
type: UnificationXref
id: Q99PS2
db: uniprot

uniprot Q923I8 103
type: UnificationXref
id: Q923I8
db: uniprot

Clock circadian regulator
type: ProteinReference
xref: uniprot F6ZYJ9 20
organism: Xenopus tropicalis

Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a
type: ProteinReference
xref: uniprot G7NDW2 108
xref: PTHR23042:SF52
organism: Macaca mulatta

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 7

uniprot A4QN37 80
type: UnificationXref
id: A4QN37
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11455:SF15
xref: uniprot A0A1D5Q816 77
organism: Macaca mulatta

uniprot H2R1W8 60
type: UnificationXref
id: H2R1W8
db: uniprot

Aryl hydrocarbon receptor nuclear translocator-like protein 1
type: ProteinReference
xref: uniprot Q9I8T7 114
xref: PTHR23042:SF52
organism: Gallus gallus

Uncharacterized protein
type: DnaReference
xref: PTHR11455:SF15
organism: Macaca mulatta

Casein kinase I
type: Protein
entity reference: Casein kinase I
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa3 121
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

TRANSCRIPTION_LEFT__rev_erb-RIGHT__rev_erb-_r44
type: TemplateReaction
product: rev-erb
xref: TRANSCRIPTION
participant: rev-erb
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

PARTICIPANT STOICHIOMETRY r51 144
type: Stoichiometry
physical entity: cry
stoichiometric coefficient: 1.0

Cryptochrome-1
type: DnaReference
xref: PTHR11455:SF16
organism: Rattus norvegicus

Cryptochrome circadian regulator 1ba
type: ProteinReference
xref: uniprot B0S7X5 82
organism: Danio rerio

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 6

Per s1 a1 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY r51 145
type: Stoichiometry
physical entity: cry
stoichiometric coefficient: 1.0

uniprot Q7T2E3 47
type: UnificationXref
id: Q7T2E3
db: uniprot

uniprot A0A2I3RNZ3 106
type: UnificationXref
id: A0A2I3RNZ3
db: uniprot

Clock
type: ProteinReference
xref: P00501
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.PROTEIN.GENERIC.Clock
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Clock Synonym: Clk Accession: P00501
member entity reference: Clock circadian regulator a
member entity reference: Clock circadian regulator
member entity reference: Circadian locomoter output cycles protein kaput
member entity reference: CLOCK isoform 1
member entity reference: Uncharacterized protein
member entity reference: Clock circadian regulator b

Casein kinase I isoform delta
type: ProteinReference
xref: uniprot Q9DC28 49
xref: PTHR11909:SF378
organism: Mus musculus

ncbitaxon 9913 8
type: UnificationXref
id: 9913
db: ncbitaxon

Aryl hydrocarbon receptor nuclear translocator like
type: ProteinReference
xref: PTHR23042:SF52
xref: uniprot A0A2I3RNZ3 106
organism: Pan troglodytes

ncbitaxon 7955 9
type: UnificationXref
id: 7955
db: ncbitaxon

cry
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.RNA.RNA.cry
comment: ENTITY_REFERENCE_NOTES=Long Name: cry Synonym: Cry1,Cry2,Cryptochrome 1,Cryptochrome2 Accession: G01497

Casein kinase I s11 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Casein kinase I
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

TRANSPORT_LEFT__Complex__Per_Cry__Casein_kinase_I_-RIGHT__Complex__Per_Cry__Casein_kinase_I_-_r17
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 157
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 158
left: Complex (Per/Cry/ Casein kinase I)
interaction type: TRANSPORT
right: Complex (Per/Cry/ Casein kinase I)

bmal1
type: DnaRegion
entity reference: Brain and Muscle Arnt-Like 1
cellular location: nucleus
comment: SPECIES_TYPE=GENE

TRANSPORT_LEFT__per-RIGHT__per-_r47
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 159
participant stoichiometry: PARTICIPANT STOICHIOMETRY r47 160
left: per
interaction type: TRANSPORT
right: per

STATE_TRANSITION_LEFT__Complex__BMAL1_Clock_-RIGHT__Complex__BMAL1_Clock_-_re28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 172
left: Complex (BMAL1/Clock)
interaction type: STATE_TRANSITION
right: Complex (BMAL1/Clock)

uniprot F6TBG4 36
type: UnificationXref
id: F6TBG4
db: uniprot

PARTICIPANT STOICHIOMETRY r38 149
type: Stoichiometry
physical entity: Rev-erb
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r38 148
type: Stoichiometry
physical entity: Rev-erb
stoichiometric coefficient: 1.0

uniprot A0A1D5QIX4 51
type: UnificationXref
id: A0A1D5QIX4
db: uniprot

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__cry-RIGHT__cry-_r45
control type: ACTIVATION
controller: Complex (BMAL1/Clock)

PARTICIPANT STOICHIOMETRY r1 178
type: Stoichiometry
physical entity: Per
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FPX9 38
xref: PTHR11909:SF378
organism: Monodelphis domestica

uniprot P48730 41
type: UnificationXref
id: P48730
db: uniprot

Clock
type: Protein
entity reference: Clock
feature: COMPLEX PARTICIPANT BINDING FEATURE s57 sa12 135
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YLJ6 59
xref: PTHR11269:SF9
organism: Macaca mulatta

Uncharacterized protein
type: DnaReference
xref: PTHR11269:SF8
organism: Bos taurus

uniprot Q9DC28 49
type: UnificationXref
id: Q9DC28
db: uniprot

cry
type: RnaRegion
entity reference: cry
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=RNA

uniprot Q8LB72 100
type: UnificationXref
id: Q8LB72
db: uniprot

Period circadian protein homolog 2
type: DnaReference
xref: PTHR11269:SF9
organism: Gallus gallus

ncbitaxon 3702 75
type: UnificationXref
id: 3702
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r1 179
type: Stoichiometry
physical entity: Per
stoichiometric coefficient: 1.0

Aryl hydrocarbon receptor nuclear translocator-like 1a
type: DnaReference
organism: Danio rerio

uniprot F1N0J9 84
type: UnificationXref
id: F1N0J9
db: uniprot

Cry1a protein
type: ProteinReference
xref: uniprot A4QN37 80
organism: Danio rerio

Cryptochrome-2
type: ProteinReference
xref: uniprot Q96524 104
organism: Arabidopsis thaliana

Casein kinase I isoform delta
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q06486 43
organism: Rattus norvegicus

Cryptochrome circadian regulator 2
type: DnaReference
xref: PTHR11455:SF15
organism: Canis lupus familiaris

Cryptochrome
type: DnaRegionReference
member entity reference: CRY2 isoform 1
member entity reference: Cryptochrome-1
member entity reference: Cryptochrome circadian regulator 2
member entity reference: Cryptochrome 1a
member entity reference: Os04g0452100 protein
member entity reference: Cryptochrome-2
member entity reference: Cryptochrome circadian regulator 1
member entity reference: Cryptochrome circadian regulator 5
member entity reference: Cryptochrome circadian regulator 1ba
member entity reference: Uncharacterized protein
member entity reference: Cryptochrome circadian regulator 1bb
member entity reference: CRY1 protein
member entity reference: Cryptochrome circadian regulator 1ab
member entity reference: CRY1 isoform 1
xref: G01501
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.GENE.GENE.cry
comment: ENTITY_REFERENCE_NOTES=Long Name: cry Synonym: Cry1,Cry2,Cryptochrome 1,Cryptochrome2 Accession: G01501
display name: cry

uniprot E2R0I6 55
type: UnificationXref
id: E2R0I6
db: uniprot

Cryptochrome circadian regulator 2
type: ProteinReference
xref: uniprot F1PNC9 85
xref: PTHR11455:SF15
organism: Canis lupus familiaris

TRANSPORT_LEFT__bmal1-RIGHT__bmal1-_r50
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 146
participant stoichiometry: PARTICIPANT STOICHIOMETRY r50 147
left: bmal1
interaction type: TRANSPORT
right: bmal1

Clock
type: Protein
entity reference: Clock
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P56645 68
type: UnificationXref
id: P56645
db: uniprot

BMAL1
type: ProteinReference
xref: P00506
standard name: Brain and Muscle Arnt-Like 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: BMAL1 Synonym: Bone and muscle ARNT-like 1,MOP3,cyc,cycle Accession: P00506
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.PROTEIN.GENERIC.BMAL1
member entity reference: Aryl hydrocarbon receptor nuclear translocator-like protein 1
member entity reference: Uncharacterized protein
member entity reference: Aryl hydrocarbon receptor nuclear translocator like
member entity reference: Aryl hydrocarbon receptor nuclear translocator-like 1a
member entity reference: Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a
member entity reference: Protein cycle

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 74

PTHR11455:SF16
type: RelationshipXref
id: PTHR11455:SF16
db: PANTHER Family
relationship type: By Homology

BMAL1 s56 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMAL1
stoichiometric coefficient: 1.0

PTHR11455:SF17
type: RelationshipXref
id: PTHR11455:SF17
db: PANTHER Family
relationship type: By Homology

PTHR11455:SF15
type: RelationshipXref
id: PTHR11455:SF15
db: PANTHER Family
relationship type: By Homology

Cryptochrome 1a
type: DnaReference
organism: Oryza sativa

Cryptochrome-1
type: ProteinReference
xref: uniprot Q8QG61 102
organism: Gallus gallus

Cryptochrome-2
type: ProteinReference
xref: uniprot Q8QG60 101
organism: Gallus gallus

Cry
type: ProteinReference
xref: P00505
standard name: Cryptochrome
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cry Synonym: Cry1,Cry2,Cryptochrome 1,Cryptochrome2 Accession: P00505
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.PROTEIN.GENERIC.Cry
member entity reference: CRY2 isoform 1
member entity reference: Cryptochrome-1
member entity reference: Cryptochrome circadian regulator 2
member entity reference: Cryptochrome circadian regulator 1ba
member entity reference: Uncharacterized protein
member entity reference: Cry1a protein
member entity reference: Os04g0452100 protein
member entity reference: Cryptochrome-2
member entity reference: Cryptochrome circadian regulator 5
member entity reference: Cryptochrome circadian regulator 1
member entity reference: Blue-light photoreceptor PHR2
member entity reference: CRY1 isoform 1
member entity reference: Cryptochrome 1a
member entity reference: Cryptochrome circadian regulator 1ab
member entity reference: CRY1 protein
member entity reference: Cryptochrome circadian regulator 1bb

PTHR46055:SF2
type: RelationshipXref
id: PTHR46055:SF2
db: PANTHER Family
relationship type: By Homology

TRANSPORT
type: RelationshipTypeVocabulary

Casein kinase I s7 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Casein kinase I
stoichiometric coefficient: 1.0

Per s14 a20 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Aryl hydrocarbon receptor nuclear translocator-like protein 1
type: DnaReference
xref: PTHR23042:SF52
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR11269:SF8
xref: uniprot F1MDK3 56
organism: Bos taurus

uniprot O77059 93
type: UnificationXref
id: O77059
db: uniprot

PER3 isoform 3
type: ProteinReference
xref: uniprot H2R1W8 60
xref: PTHR11269:SF13
organism: Pan troglodytes

Casein kinase I s15 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Casein kinase I
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__per-RIGHT__per-_r43
control type: ACTIVATION
controller: Complex (BMAL1/Clock)

TRANSLATION_LEFT__bmal1-RIGHT__BMAL1-_r54
type: TemplateReaction
product: BMAL1
xref: TRANSLATION
participant: bmal1
participant: BMAL1
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

PARTICIPANT STOICHIOMETRY r50 146
type: Stoichiometry
physical entity: bmal1
stoichiometric coefficient: 1.0

Cryptochrome-1
type: ProteinReference
xref: uniprot Q43125 97
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r50 147
type: Stoichiometry
physical entity: bmal1
stoichiometric coefficient: 1.0

Cryptochrome-1
type: DnaReference
organism: Arabidopsis thaliana

Cryptochrome circadian regulator 1ab
type: ProteinReference
xref: uniprot F1R1X1 87
organism: Danio rerio

PTHR11909:SF18
type: RelationshipXref
id: PTHR11909:SF18
db: PANTHER Family
relationship type: By Homology

Clock circadian regulator b
type: ProteinReference
xref: uniprot B3DH92 17
organism: Danio rerio

uniprot A0A2R8QLW6 79
type: UnificationXref
id: A0A2R8QLW6
db: uniprot

Per
type: Protein
entity reference: Per
feature: ACTIVE 73
feature: Per s8 sa5 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa5 143
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

Casein kinase I isoform delta
type: ProteinReference
xref: uniprot P48730 41
xref: PTHR11909:SF378
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__Per-_Casein_kinase_I-RIGHT__Complex__Casein_kinase_I_Per_-_r8
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 161
left: Per
left: Casein kinase I
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Casein kinase I/Per)

uniprot A0A2I3RHK0 32
type: UnificationXref
id: A0A2I3RHK0
db: uniprot

Period circadian clock 3
type: DnaReference
organism: Danio rerio

Period circadian clock 3
type: ProteinReference
xref: uniprot F1RDZ4 58
organism: Danio rerio

Casein kinase 1 epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot A0A2I3RHK0 32
organism: Pan troglodytes

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

TRANSPORT_LEFT__cry-RIGHT__cry-_r51
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 144
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 145
left: cry
interaction type: TRANSPORT
right: cry

G01499
type: UnificationXref
id: G01499
db: PANTHER Pathway Component

P00501
type: UnificationXref
id: P00501
db: PANTHER Pathway Component

P00502
type: UnificationXref
id: P00502
db: PANTHER Pathway Component

P00505
type: UnificationXref
id: P00505
db: PANTHER Pathway Component

CRY2 isoform 1
type: ProteinReference
xref: PTHR11455:SF15
xref: uniprot A0A2J8LHI8 78
organism: Pan troglodytes

P00506
type: UnificationXref
id: P00506
db: PANTHER Pathway Component

P00504
type: UnificationXref
id: P00504
db: PANTHER Pathway Component

uniprot O76324 39
type: UnificationXref
id: O76324
db: uniprot

uniprot Q8CJE2 70
type: UnificationXref
id: Q8CJE2
db: uniprot

uniprot A0A1D5NXQ4 31
type: UnificationXref
id: A0A1D5NXQ4
db: uniprot

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

Per
type: Protein
entity reference: Per
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa6 129
feature: ACTIVE 73
feature: Per s10 sa6 rs1
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

Aryl hydrocarbon receptor nuclear translocator-like protein 1
type: DnaReference
xref: PTHR23042:SF52
organism: Rattus norvegicus

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 23

uniprot P49674 42
type: UnificationXref
id: P49674
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot Q06486 43
type: UnificationXref
id: Q06486
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot Q9JMK2 50
type: UnificationXref
id: Q9JMK2
db: uniprot

Complex (Per/Casein kinase I)
type: Complex
component stoichiometry: Per s10 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: Casein kinase I s11 sa7 STOICHIOMETRY ID COMPLEX
component: Per
component: Casein kinase I
feature: COMPLEX BINDING FEATURE s24 a31 128
feature: COMPLEX BINDING FEATURE s24 a31 130
cellular location: Pacemaker Neuron c1

rev-erb
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__bmal1-RIGHT__bmal1-_r46
control type: INHIBITION
controller: Rev-erb

Period circadian protein homolog 1
type: ProteinReference
xref: PTHR11269:SF8
xref: uniprot O15534 63
organism: Homo sapiens

ncbitaxon 9606 11
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot P07663 67
type: UnificationXref
id: P07663
db: uniprot

Casein kinase 1, epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot Q99PS2 48
organism: Rattus norvegicus

CRY1 isoform 1
type: DnaReference
xref: PTHR11455:SF16
organism: Pan troglodytes

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 16

Aryl hydrocarbon receptor nuclear translocator-like protein 1
type: ProteinReference
xref: PTHR23042:SF52
xref: uniprot Q9EPW1 112
organism: Rattus norvegicus

bmal1
type: RnaRegionReference
comment: ENTITY_REFERENCE_NOTES=Long Name: bmal1 Synonym: Bone and muscle ARNT-like 1,MOP3,cyc,cycle Accession: G01504
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.RNA.RNA.bmal1

TRANSCRIPTION
type: InteractionVocabulary

Cry s5 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cry
stoichiometric coefficient: 1.0

uniprot A0A2I3RNK5 33
type: UnificationXref
id: A0A2I3RNK5
db: uniprot

uniprot O61734 111
type: UnificationXref
id: O61734
db: uniprot

uniprot F6YLJ6 59
type: UnificationXref
id: F6YLJ6
db: uniprot

Period
type: DnaRegionReference
member entity reference: Period circadian protein homolog 2
member entity reference: Period circadian protein homolog 1
member entity reference: Uncharacterized protein
member entity reference: Period circadian protein
member entity reference: Period circadian protein homolog 3
member entity reference: Period circadian regulator 1
member entity reference: PER3 isoform 3
member entity reference: Period circadian clock 3
member entity reference: PER1 isoform 1
xref: G01499
comment: ENTITY_REFERENCE_NOTES=Long Name: per Synonym: Per1,Per2,Per3,Period,Period1,Period2,Period3,hPer1,hPer2,hPer3,mPer1,mPer2,mPer3 Accession: G01499
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.GENE.GENE.per
display name: per

Per s3 sa1 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Casein kinase I
type: Protein
entity reference: Casein kinase I
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa7 131
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

Per
type: ProteinReference
xref: P00504
standard name: Period
comment: ENTITY_REFERENCE_NOTES=Long Name: Per Synonym: Per1,Per2,Per3,Period,Period1,Period2,Period3,hPer1,hPer2,hPer3,mPer1,mPer2,mPer3 Accession: P00504
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Circadian clock system.PROTEIN.GENERIC.Per
member entity reference: Period circadian protein homolog 1
member entity reference: Period circadian clock 3
member entity reference: Period circadian protein homolog 2
member entity reference: Period circadian protein homolog 3
member entity reference: Uncharacterized protein
member entity reference: Period circadian protein
member entity reference: Period circadian regulator 1
member entity reference: PER1 isoform 1
member entity reference: PER3 isoform 3
member entity reference: Period circadian clock 1b
member entity reference: Period circadian clock 2

uniprot Q8QG60 101
type: UnificationXref
id: Q8QG60
db: uniprot

PANTHER Pathway P00015 1
type: UnificationXref
id: P00015
db: PANTHER Pathway

PTHR23042:SF99
type: RelationshipXref
id: PTHR23042:SF99
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Complex__Per_Casein_kinase_I_-_Cry-RIGHT__Complex__Per_Cry__Casein_kinase_I_-_r15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 166
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 165
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 164
left: Complex (Per/Casein kinase I)
left: Cry
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Per/Cry/ Casein kinase I)

Clock circadian regulator
type: ProteinReference
xref: uniprot F1MLT7 18
xref: PTHR46055:SF2
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r17 158
type: Stoichiometry
physical entity: Complex (Per/Cry/ Casein kinase I)
stoichiometric coefficient: 1.0

DISSOCIATION
type: InteractionVocabulary

Circadian locomoter output cycles protein kaput
type: ProteinReference
xref: uniprot O08785 26
xref: PTHR46055:SF2
organism: Mus musculus

Pacemaker Neuron c1
type: CellularLocationVocabulary
comment: Pacemaker Neuron

Casein kinase I isoform delta
type: ProteinReference
xref: uniprot P35508 40
xref: PTHR11909:SF378
organism: Bos taurus

Uncharacterized protein
type: DnaReference
xref: PTHR11269:SF9
organism: Macaca mulatta

Casein kinase I isoform epsilon
type: ProteinReference
xref: PTHR11909:SF18
xref: uniprot Q9JMK2 50
organism: Mus musculus

ADP
type: SmallMolecule
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8QGQ6 29
type: UnificationXref
id: Q8QGQ6
db: uniprot

uniprot Q9EPW1 112
type: UnificationXref
id: Q9EPW1
db: uniprot

uniprot F7FPX9 38
type: UnificationXref
id: F7FPX9
db: uniprot

uniprot Q9WTL8 115
type: UnificationXref
id: Q9WTL8
db: uniprot

Per s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Per
stoichiometric coefficient: 1.0

uniprot Q49AN0 98
type: UnificationXref
id: Q49AN0
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 11

PARTICIPANT STOICHIOMETRY r17 157
type: Stoichiometry
physical entity: Complex (Per/Cry/ Casein kinase I)
stoichiometric coefficient: 1.0

BMAL1
type: Protein
entity reference: BMAL1
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r13 170
type: Stoichiometry
physical entity: Per
stoichiometric coefficient: 1.0

PTHR11269:SF13
type: RelationshipXref
id: PTHR11269:SF13
db: PANTHER Family
relationship type: By Homology

Period circadian protein homolog 1
type: DnaReference
xref: PTHR11269:SF8
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r13 171
type: Stoichiometry
physical entity: Casein kinase I
stoichiometric coefficient: 1.0

uniprot F1MDK3 56
type: UnificationXref
id: F1MDK3
db: uniprot

PTHR11269:SF16
type: RelationshipXref
id: PTHR11269:SF16
db: PANTHER Family
relationship type: By Homology

uniprot O00327 110
type: UnificationXref
id: O00327
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NXQ4 31
xref: PTHR11909:SF378
organism: Gallus gallus

Per
type: Protein
entity reference: Per
feature: Per s1 a1 rs1
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=PROTEIN

Per s10 sa6 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 75

Os04g0452100 protein
type: DnaReference
organism: Oryza sativa

PARTICIPANT STOICHIOMETRY r47 159
type: Stoichiometry
physical entity: per
stoichiometric coefficient: 1.0

Cryptochrome-1
type: ProteinReference
xref: uniprot F7ENG9 91
xref: PTHR11455:SF16
organism: Macaca mulatta

uniprot Q96524 104
type: UnificationXref
id: Q96524
db: uniprot

PER1 isoform 1
type: DnaReference
xref: PTHR11269:SF8
organism: Pan troglodytes

Per
type: Protein
entity reference: Per
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa8 123
feature: Per s12 sa8 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 39947 74
type: UnificationXref
id: 39947
db: ncbitaxon

Clock s57 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Clock
stoichiometric coefficient: 1.0

uniprot A7YWC2 81
type: UnificationXref
id: A7YWC2
db: uniprot

TRANSCRIPTION_LEFT__per-RIGHT__per-_r43
type: TemplateReaction
product: per
xref: TRANSCRIPTION
participant: per
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

uniprot Q32Q86 96
type: UnificationXref
id: Q32Q86
db: uniprot

Period circadian clock 2
type: ProteinReference
xref: PTHR11269:SF9
xref: uniprot F1QUT1 57
organism: Danio rerio

Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a
type: DnaReference
xref: PTHR23042:SF52
organism: Macaca mulatta

Aryl hydrocarbon receptor nuclear translocator-like protein 1
type: ProteinReference
xref: PTHR23042:SF52
xref: uniprot O00327 110
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r13 169
type: Stoichiometry
physical entity: Complex (Per/Casein kinase I)
stoichiometric coefficient: 1.0

Danio rerio
type: BioSource
xref: ncbitaxon 7955 9

INHIBITION
type: TemplateReactionRegulation
xref: INHIBITION
controlled: TRANSCRIPTION_LEFT__rev_erb-RIGHT__rev_erb-_r44
control type: INHIBITION
controller: Complex (Per/Cry/ Casein kinase I)

STATE_TRANSITION_LEFT__Per-RIGHT__a20_degraded-_r6
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 167
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 168
left: Per
interaction type: STATE_TRANSITION
right: a20_degraded

PARTICIPANT STOICHIOMETRY r47 160
type: Stoichiometry
physical entity: per
stoichiometric coefficient: 1.0

Cry
type: Protein
entity reference: Cry
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa9 125
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Per s12 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Per
stoichiometric coefficient: 1.0

uniprot Q9I8T7 114
type: UnificationXref
id: Q9I8T7
db: uniprot

uniprot Q9WVS9 30
type: UnificationXref
id: Q9WVS9
db: uniprot

uniprot Q6P3K7 45
type: UnificationXref
id: Q6P3K7
db: uniprot

uniprot K7CRG5 61
type: UnificationXref
id: K7CRG5
db: uniprot

PTHR23042:SF52
type: RelationshipXref
id: PTHR23042:SF52
db: PANTHER Family
relationship type: By Homology

rev-erb
type: RnaRegion
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=RNA

Circadian locomoter output cycles protein kaput
type: ProteinReference
xref: uniprot Q8QGQ6 29
organism: Gallus gallus

TRANSCRIPTION
type: RelationshipTypeVocabulary

Cryptochrome-1
type: DnaReference
xref: PTHR11455:SF16
organism: Mus musculus

PHYSICAL_STIMULATION
type: TemplateReactionRegulation
xref: PHYSICAL STIMULATION
controlled: TRANSCRIPTION_LEFT__rev_erb-RIGHT__rev_erb-_r44
control type: ACTIVATION
controller: Complex (BMAL1/Clock)

Period circadian protein homolog 2
type: ProteinReference
xref: uniprot Q8QGQ8 71
xref: PTHR11269:SF9
organism: Gallus gallus

uniprot F1PNC9 85
type: UnificationXref
id: F1PNC9
db: uniprot

Circadian locomoter output cycles protein kaput
type: ProteinReference
xref: PTHR46055:SF2
xref: uniprot H9G272 25
organism: Macaca mulatta

TRANSCRIPTION_LEFT__cry-RIGHT__cry-_r45
type: TemplateReaction
product: cry
xref: TRANSCRIPTION
participant: cry
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

STATE_TRANSITION_LEFT__Per-RIGHT__Per-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 179
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 178
left: Per
interaction type: STATE_TRANSITION
right: Per

uniprot A0A2J8LHI8 78
type: UnificationXref
id: A0A2J8LHI8
db: uniprot

uniprot F6X865 89
type: UnificationXref
id: F6X865
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Casein kinase I isoform delta-B
type: ProteinReference
xref: uniprot Q6P3K7 45
xref: PTHR11909:SF378
organism: Danio rerio

Uncharacterized protein
type: DnaReference
xref: PTHR23042:SF52
organism: Bos taurus

Casein kinase 1 delta
type: ProteinReference
xref: uniprot F6TBG4 36
xref: PTHR11909:SF378
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY re28 172
type: Stoichiometry
physical entity: Complex (BMAL1/Clock)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 173
type: Stoichiometry
physical entity: Complex (BMAL1/Clock)
stoichiometric coefficient: 1.0

uniprot B3DK47 53
type: UnificationXref
id: B3DK47
db: uniprot

Cryptochrome-2
type: DnaReference
xref: PTHR11455:SF15
organism: Mus musculus

BMAL1 s56 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: BMAL1
stoichiometric coefficient: 1.0

Per s8 sa5 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Cryptochrome-2
type: ProteinReference
xref: PTHR11455:SF15
xref: uniprot Q923I8 103
organism: Rattus norvegicus

PER3 isoform 3
type: DnaReference
xref: PTHR11269:SF13
organism: Pan troglodytes

Per s1 a16 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ATP
type: SmallMolecule
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CRY1 protein
type: ProteinReference
xref: PTHR11455:SF16
xref: uniprot A7YWC2 81
organism: Bos taurus

Casein kinase I isoform delta-A
type: ProteinReference
xref: PTHR11909:SF378
xref: uniprot Q7T2E3 47
organism: Danio rerio

uniprot Q9I879 113
type: UnificationXref
id: Q9I879
db: uniprot

bmal1
type: RnaRegion
entity reference: bmal1
cellular location: nucleus
comment: SPECIES_TYPE=RNA

TRANSLATION_LEFT__cry-RIGHT__Cry-_r53
type: TemplateReaction
product: Cry
xref: TRANSLATION
participant: cry
participant: Cry
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot A0A1D5R421 52
type: UnificationXref
id: A0A1D5R421
db: uniprot

CRY1 isoform 1
type: ProteinReference
xref: uniprot H2Q6S7 92
xref: PTHR11455:SF16
organism: Pan troglodytes

Complex (BMAL1/Clock)
type: Complex
component stoichiometry: BMAL1 s56 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Clock s57 sa12 STOICHIOMETRY ID COMPLEX
component: BMAL1
component: Clock
feature: ACTIVE 73
feature: COMPLEX BINDING FEATURE s37 a46 132
feature: COMPLEX BINDING FEATURE s37 a46 134
cellular location: nucleus

Cryptochrome circadian regulator 2
type: ProteinReference
xref: PTHR11455:SF15
xref: uniprot F1N0J9 84
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR11269:SF8
xref: uniprot A0A1D5QIX4 51
organism: Macaca mulatta

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 15

Clock s57 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Clock
stoichiometric coefficient: 1.0

Rev-erb
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Cryptochrome-1
type: ProteinReference
xref: PTHR11455:SF16
xref: uniprot Q32Q86 96
organism: Rattus norvegicus

uniprot F1Q126 34
type: UnificationXref
id: F1Q126
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

IDA
type: EvidenceCodeVocabulary

uniprot F1MLT7 18
type: UnificationXref
id: F1MLT7
db: uniprot

INHIBITION
type: RelationshipTypeVocabulary

Cryptochrome 1a
type: ProteinReference
xref: uniprot Q6YXC2 99
organism: Oryza sativa

Cryptochrome-1
type: DnaReference
xref: PTHR11455:SF17
organism: Drosophila melanogaster

Aryl hydrocarbon receptor nuclear translocator like
type: DnaReference
xref: PTHR23042:SF52
organism: Pan troglodytes

cry
type: DnaRegion
entity reference: Cryptochrome
cellular location: nucleus
comment: SPECIES_TYPE=GENE

per
type: RnaRegion
entity reference: per
cellular location: Pacemaker Neuron c1
comment: SPECIES_TYPE=RNA

Cryptochrome-2
type: ProteinReference
xref: PTHR11455:SF15
xref: uniprot Q9R194 105
organism: Mus musculus

uniprot B0S7X5 82
type: UnificationXref
id: B0S7X5
db: uniprot

ncbitaxon 9031 6
type: UnificationXref
id: 9031
db: ncbitaxon

Cryptochrome-1
type: ProteinReference
xref: uniprot Q16526 95
xref: PTHR11455:SF16
organism: Homo sapiens

uniprot F1RDZ4 58
type: UnificationXref
id: F1RDZ4
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__BMAL1-_Clock-RIGHT__Complex__BMAL1_Clock_-_r18
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 152
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 154
left: Clock
left: BMAL1
interaction type: HETERODIMER_ASSOCIATION
right: Complex (BMAL1/Clock)

Cryptochrome circadian regulator 5
type: ProteinReference
xref: uniprot F1QHM9 86
organism: Danio rerio

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__Complex__BMAL1_Clock_-RIGHT__Complex__BMAL1_Clock_-_re28
control type: ACTIVATION
controller: Complex (Per/Cry/ Casein kinase I)

Period circadian protein homolog 1
type: DnaReference
xref: PTHR11269:SF8
organism: Mus musculus

Uncharacterized protein
type: DnaReference
xref: PTHR11269:SF8
organism: Macaca mulatta

Clock circadian regulator
type: ProteinReference
xref: uniprot F1PSD8 19
xref: PTHR46055:SF2
organism: Canis lupus familiaris

Circadian locomoter output cycles protein kaput
type: ProteinReference
xref: uniprot Q9WVS9 30
xref: PTHR46055:SF2
organism: Rattus norvegicus

uniprot Q8QG61 102
type: UnificationXref
id: Q8QG61
db: uniprot

Circadian locomoter output cycles protein kaput
type: ProteinReference
xref: PTHR46055:SF2
xref: uniprot O15516 27
organism: Homo sapiens

STATE_TRANSITION
type: InteractionVocabulary

ncbitaxon 9258 37
type: UnificationXref
id: 9258
db: ncbitaxon

Aryl hydrocarbon receptor nuclear translocator like
type: DnaReference
xref: PTHR23042:SF52
organism: Canis lupus familiaris

uniprot J9NTT7 109
type: UnificationXref
id: J9NTT7
db: uniprot

TRANSPORT
type: InteractionVocabulary

Period circadian protein
type: DnaReference
xref: PTHR11269:SF16
organism: Drosophila melanogaster

PTHR11909:SF378
type: RelationshipXref
id: PTHR11909:SF378
db: PANTHER Family
relationship type: By Homology

uniprot F1QHM9 86
type: UnificationXref
id: F1QHM9
db: uniprot

Os04g0452100 protein
type: ProteinReference
xref: uniprot A0A0P0WAS3 76
organism: Oryza sativa

Period circadian protein homolog 2
type: DnaReference
organism: Rattus norvegicus

Cryptochrome-1
type: DnaReference
xref: PTHR11455:SF16
organism: Homo sapiens

Cryptochrome-2
type: DnaReference
xref: PTHR11455:SF15
organism: Homo sapiens

Aryl hydrocarbon receptor nuclear translocator-like protein 1
type: ProteinReference
xref: PTHR23042:SF52
xref: uniprot Q9WTL8 115
organism: Mus musculus

Casein kinase I
type: Protein
entity reference: Casein kinase I
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa10 127
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q8QGQ8 71
type: UnificationXref
id: Q8QGQ8
db: uniprot

uniprot Q6YXC2 99
type: UnificationXref
id: Q6YXC2
db: uniprot

PARTICIPANT STOICHIOMETRY r18 153
type: Stoichiometry
physical entity: Clock
stoichiometric coefficient: 1.0

uniprot F7ENG9 91
type: UnificationXref
id: F7ENG9
db: uniprot

PARTICIPANT STOICHIOMETRY r18 154
type: Stoichiometry
physical entity: Complex (BMAL1/Clock)
stoichiometric coefficient: 1.0

uniprot H9G272 25
type: UnificationXref
id: H9G272
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DL74 22
xref: PTHR46055:SF2
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r18 152
type: Stoichiometry
physical entity: BMAL1
stoichiometric coefficient: 1.0

uniprot P97784 94
type: UnificationXref
id: P97784
db: uniprot

rev-erb
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

PARTICIPANT STOICHIOMETRY r8 161
type: Stoichiometry
physical entity: Per
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 162
type: Stoichiometry
physical entity: Casein kinase I
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 163
type: Stoichiometry
physical entity: Complex (Casein kinase I/Per)
stoichiometric coefficient: 1.0

uniprot O15516 27
type: UnificationXref
id: O15516
db: uniprot

Period circadian protein homolog 3
type: ProteinReference
xref: uniprot Q8CJE2 70
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

CSNK1D isoform 8
type: ProteinReference
xref: uniprot A0A2I3RNK5 33
xref: PTHR11909:SF378
organism: Pan troglodytes

Protein cycle
type: ProteinReference
xref: PTHR23042:SF99
xref: uniprot O61734 111
organism: Drosophila melanogaster

Protein cycle
type: DnaReference
xref: PTHR23042:SF99
organism: Drosophila melanogaster

Complex (Per/Cry/ Casein kinase I)
type: Complex
component stoichiometry: Cry s13 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: Casein kinase I s15 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Per s12 sa8 STOICHIOMETRY ID COMPLEX
component: Per
component: Cry
component: Casein kinase I
feature: COMPLEX BINDING FEATURE s34 a41 126
feature: COMPLEX BINDING FEATURE s34 a41 124
feature: COMPLEX BINDING FEATURE s34 a41 122
cellular location: nucleus

Cry s13 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cry
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot E1C8E2 54
organism: Gallus gallus

Cryptochrome circadian regulator 1
type: ProteinReference
xref: PTHR11455:SF16
xref: uniprot E2RMX4 83
organism: Canis lupus familiaris

Clock circadian regulator a
type: ProteinReference
xref: uniprot Q5RIV1 28
organism: Danio rerio