MODEL_NOTES=Panther Pathway: P00015 This is the current model of the molecular circadian pacemaker. In mammals, the core circadian pacemaker is found in the neurons of the suprachiasmatic nucleus. This pacemaker can synchronize peripheral clocks located throughout the animal to the rhythm of the core pacemaker. Note that the fluctuation of both protein and mRNA levels of many components of the clock are important for normal periodicity. There are important threshhold levels which proteins and mRNAs much reach before the next step of the pathway can proceed. This gives the pacemaker the ability to "free run" in the absence of external cues with a period of approximately 24 hours. Medline=12198538 Medline=12446131 Medline=12724733 PMID: 12198538 PMID: 12446131 PMID: 12724733
Aryl hydrocarbon receptor nuclear translocator-like protein 1
ENTITY_REFERENCE_ID_DESC=Circadian clock system.PROTEIN.GENERIC.Casein_space_kinase_space_I
ENTITY_REFERENCE_NOTES=Long Name: Casine kinase I Synonym: CKI,Doubletime,dbt Accession: P00502
ENTITY_REFERENCE_ID_DESC=Circadian clock system.GENE.GENE.bmal1
ENTITY_REFERENCE_NOTES=Long Name: Brain and Muscle Arnt-Like 1 Synonym: MOP3 Accession: G01500
Aryl hydrocarbon receptor nuclear translocator like
Aryl hydrocarbon receptor nuclear translocator-like 1a
ENTITY_REFERENCE_ID_DESC=Circadian clock system.RNA.RNA.per
ENTITY_REFERENCE_NOTES=Long Name: per Synonym: Per1,Per2,Per3,Period,Period1,Period2,Period3,hPer1,hPer2,hPer3,mPer1,mPer2,mPer3 Accession: G01503
Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a
ENTITY_REFERENCE_ID_DESC=Circadian clock system.PROTEIN.GENERIC.Clock
ENTITY_REFERENCE_NOTES=Long Name: Clock Synonym: Clk Accession: P00501
ENTITY_REFERENCE_ID_DESC=Circadian clock system.RNA.RNA.cry
ENTITY_REFERENCE_NOTES=Long Name: cry Synonym: Cry1,Cry2,Cryptochrome 1,Cryptochrome2 Accession: G01497
ENTITY_REFERENCE_ID_DESC=Circadian clock system.GENE.GENE.cry
ENTITY_REFERENCE_NOTES=Long Name: cry Synonym: Cry1,Cry2,Cryptochrome 1,Cryptochrome2 Accession: G01501
ENTITY_REFERENCE_NOTES=Long Name: BMAL1 Synonym: Bone and muscle ARNT-like 1,MOP3,cyc,cycle Accession: P00506
ENTITY_REFERENCE_ID_DESC=Circadian clock system.PROTEIN.GENERIC.BMAL1
ENTITY_REFERENCE_NOTES=Long Name: Cry Synonym: Cry1,Cry2,Cryptochrome 1,Cryptochrome2 Accession: P00505
ENTITY_REFERENCE_ID_DESC=Circadian clock system.PROTEIN.GENERIC.Cry
ENTITY_REFERENCE_NOTES=Long Name: bmal1 Synonym: Bone and muscle ARNT-like 1,MOP3,cyc,cycle Accession: G01504
ENTITY_REFERENCE_ID_DESC=Circadian clock system.RNA.RNA.bmal1
ENTITY_REFERENCE_NOTES=Long Name: per Synonym: Per1,Per2,Per3,Period,Period1,Period2,Period3,hPer1,hPer2,hPer3,mPer1,mPer2,mPer3 Accession: G01499
ENTITY_REFERENCE_ID_DESC=Circadian clock system.GENE.GENE.per
ENTITY_REFERENCE_NOTES=Long Name: Per Synonym: Per1,Per2,Per3,Period,Period1,Period2,Period3,hPer1,hPer2,hPer3,mPer1,mPer2,mPer3 Accession: P00504
ENTITY_REFERENCE_ID_DESC=Circadian clock system.PROTEIN.GENERIC.Per
Circadian locomoter output cycles protein kaput