STATE_TRANSITION_LEFT__GTP-_adenosylcobinamide_phosphate-RIGHT__PPi-_adenosylcobinamide_GDP-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 9
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 8
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 7
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 6
left: GTP
left: adenosylcobinamide phosphate
interaction type: STATE_TRANSITION
right: adenosylcobinamide-GDP
right: PPi

STATE_TRANSITION_LEFT__PPi-_Adenosylcobalamin-_PO4-RIGHT__ATP-_H2O-_Cob_I_alamin-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 31
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 28
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 32
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 30
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 33
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 29
left: Adenosylcobalamin
left: PPi
left: PO4
interaction type: STATE_TRANSITION
right: Cob(I)alamin
right: H2O
right: ATP

PARTICIPANT STOICHIOMETRY r3 7
type: Stoichiometry
physical entity: adenosylcobinamide phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 6
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 9
type: Stoichiometry
physical entity: adenosylcobinamide-GDP
stoichiometric coefficient: 1.0

Adenosylcobalamin/alpha-ribazole phosphatase
type: ProteinReference
xref: uniprot P52086 2
organism: Escherichia coli

uniprot Q7SBZ4 4
type: UnificationXref
id: Q7SBZ4
db: uniprot

PARTICIPANT STOICHIOMETRY r3 8
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

Cob(I)alamin
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ribazole
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cobalamin Adenosyl transferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_H2O-_cobinaminde-RIGHT__ADP-_PPi-_adenosylcobinamide-_r1
controller: Cobinamide adenosyl transferase

STATE_TRANSITION_LEFT__ATP-_H2O-_cobinaminde-RIGHT__ADP-_PPi-_adenosylcobinamide-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 17
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 18
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 15
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 16
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 19
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 14
left: H2O
left: ATP
left: cobinaminde
interaction type: STATE_TRANSITION
right: PPi
right: ADP
right: adenosylcobinamide

PANTHER Pathway P02735 1
type: UnificationXref
id: P02735
db: PANTHER Pathway

STATE_TRANSITION_LEFT__nicotinate_nucleotide-_DMBI-RIGHT__niacine-_ribazol_5_phosphate-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 25
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 24
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 26
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 27
left: nicotinate nucleotide
left: DMBI
interaction type: STATE_TRANSITION
right: niacine
right: ribazol-5-phosphate

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION
type: InteractionVocabulary

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__ATP-_adenosylcobinamide-RIGHT__ADP-_adenosylcobinamide_phosphate-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 13
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 12
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 11
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 10
left: adenosylcobinamide
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: adenosylcobinamide phosphate

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__adenosylcobinamide_GDP-_ribazole-RIGHT__GMP-_Adenosylcobalamin-_r4
controller: Cobalamin synthase

uniprot P52086 2
type: UnificationXref
id: P52086
db: uniprot

ribazol-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Adenosylcobalamin
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cobalamin biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__H2O-_ribazol_5_phosphate-RIGHT__ribazole-_PO4-_r7
pathway component: STATE_TRANSITION_LEFT__adenosylcobinamide_GDP-_ribazole-RIGHT__GMP-_Adenosylcobalamin-_r4
pathway component: STATE_TRANSITION_LEFT__nicotinate_nucleotide-_DMBI-RIGHT__niacine-_ribazol_5_phosphate-_r6
pathway component: STATE_TRANSITION_LEFT__ATP-_H2O-_cobinaminde-RIGHT__ADP-_PPi-_adenosylcobinamide-_r1
pathway component: STATE_TRANSITION_LEFT__GTP-_adenosylcobinamide_phosphate-RIGHT__PPi-_adenosylcobinamide_GDP-_r3
pathway component: STATE_TRANSITION_LEFT__PPi-_Adenosylcobalamin-_PO4-RIGHT__ATP-_H2O-_Cob_I_alamin-_r5
pathway component: STATE_TRANSITION_LEFT__ATP-_adenosylcobinamide-RIGHT__ADP-_adenosylcobinamide_phosphate-_r2
xref: PANTHER Pathway P02735 1
comment: MODEL_NOTES=Cobalamin (Vitamin B12) is an important cofactor in several metabolic methylation reactions. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

GTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cobinamide-phosphate guanyltransferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

DMBI
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ribazole-5-phosphate phosphatase
type: ProteinReference
xref: P02881
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ribazole-5-phosphate phosphatase Synonym: Synonym not specified Accession: P02881
comment: ENTITY_REFERENCE_ID_DESC=Cobalamin biosynthesis.PROTEIN.GENERIC.Ribazole-5-phosphate_br_phosphatase
member entity reference: Adenosylcobalamin/alpha-ribazole phosphatase
member entity reference: Phosphoglycerate mutase

adenosylcobinamide
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 367110 5
type: UnificationXref
id: 367110
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PPi-_Adenosylcobalamin-_PO4-RIGHT__ATP-_H2O-_Cob_I_alamin-_r5
controller: Cobalamin Adenosyl transferase

STATE_TRANSITION_LEFT__adenosylcobinamide_GDP-_ribazole-RIGHT__GMP-_Adenosylcobalamin-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 36
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 35
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 37
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 34
left: ribazole
left: adenosylcobinamide-GDP
interaction type: STATE_TRANSITION
right: Adenosylcobalamin
right: GMP

niacine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r2 11
type: Stoichiometry
physical entity: adenosylcobinamide
stoichiometric coefficient: 1.0

adenosylcobinamide-GDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r2 10
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 13
type: Stoichiometry
physical entity: adenosylcobinamide phosphate
stoichiometric coefficient: 1.0

ncbitaxon 83333 3
type: UnificationXref
id: 83333
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r2 12
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 35
type: Stoichiometry
physical entity: ribazole
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 33
type: Stoichiometry
physical entity: Cob(I)alamin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 34
type: Stoichiometry
physical entity: adenosylcobinamide-GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 24
type: Stoichiometry
physical entity: nicotinate nucleotide
stoichiometric coefficient: 1.0

cobinaminde
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ribazole-5-phosphate phosphatase
type: Protein
entity reference: Ribazole-5-phosphate phosphatase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r4 37
type: Stoichiometry
physical entity: Adenosylcobalamin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 31
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 36
type: Stoichiometry
physical entity: GMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 32
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 27
type: Stoichiometry
physical entity: ribazol-5-phosphate
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_ribazol_5_phosphate-RIGHT__ribazole-_PO4-_r7
controller: Ribazole-5-phosphate phosphatase

PARTICIPANT STOICHIOMETRY r6 25
type: Stoichiometry
physical entity: DMBI
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 23
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 26
type: Stoichiometry
physical entity: niacine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 22
type: Stoichiometry
physical entity: ribazole
stoichiometric coefficient: 1.0

Phosphoglycerate mutase
type: ProteinReference
xref: uniprot Q7SBZ4 4
organism: Neurospora crassa

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_adenosylcobinamide-RIGHT__ADP-_adenosylcobinamide_phosphate-_r2
controller: Cobinamide kinase

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__nicotinate_nucleotide-_DMBI-RIGHT__niacine-_ribazol_5_phosphate-_r6
controller: Dimethylbenzimidazol phosphribosyl transferase

PARTICIPANT STOICHIOMETRY r1 18
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__H2O-_ribazol_5_phosphate-RIGHT__ribazole-_PO4-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 21
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 20
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 22
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 23
left: H2O
left: ribazol-5-phosphate
interaction type: STATE_TRANSITION
right: ribazole
right: PO4

PARTICIPANT STOICHIOMETRY r1 17
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Cobinamide adenosyl transferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r1 19
type: Stoichiometry
physical entity: adenosylcobinamide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 14
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 16
type: Stoichiometry
physical entity: cobinaminde
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 15
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

P02881
type: UnificationXref
id: P02881
db: PANTHER Pathway Component

Dimethylbenzimidazol phosphribosyl transferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r5 28
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 5

PARTICIPANT STOICHIOMETRY r5 29
type: Stoichiometry
physical entity: Adenosylcobalamin
stoichiometric coefficient: 1.0

GMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 3

adenosylcobinamide phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cobalamin synthase
type: Protein
comment: SPECIES_TYPE=PROTEIN

Cobinamide kinase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r7 20
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 21
type: Stoichiometry
physical entity: ribazol-5-phosphate
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_adenosylcobinamide_phosphate-RIGHT__PPi-_adenosylcobinamide_GDP-_r3
controller: Cobinamide-phosphate guanyltransferase

PARTICIPANT STOICHIOMETRY r5 30
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

nicotinate nucleotide
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE