Pantothenate kinase 3
type: ProteinReference
xref: uniprot Q08DA5 93
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__4_phospho_N_pantothenoylcysteine-RIGHT__CO2-_pantetheine_4_phosphate-_r3
controller: Pantothenoylcysteine decarboxylase

uniprot Q8VDG5 25
type: UnificationXref
id: Q8VDG5
db: uniprot

Pantothenate kinase 4
type: ProteinReference
xref: uniprot Q9NVE7 108
organism: Homo sapiens

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 11

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot Q8TK70 117
organism: Methanosarcina acetivorans

uniprot Q7NMB9 112
type: UnificationXref
id: Q7NMB9
db: uniprot

uniprot A9ULG9 77
type: UnificationXref
id: A9ULG9
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 58

ncbitaxon 6238 39
type: UnificationXref
id: 6238
db: ncbitaxon

Pantothenate kinase 4
type: ProteinReference
xref: uniprot F7GTZ5 85
organism: Macaca mulatta

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot Q9WZK0 119
organism: Thermotoga maritima

ncbitaxon 9606 28
type: UnificationXref
id: 9606
db: ncbitaxon

ncbitaxon 6239 49
type: UnificationXref
id: 6239
db: ncbitaxon

PANK1 isoform 1
type: ProteinReference
xref: uniprot A0A2I3SAC6 73
organism: Pan troglodytes

uniprot Q9WZK0 119
type: UnificationXref
id: Q9WZK0
db: uniprot

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot Q8EYP6 115
organism: Leptospira interrogans

PaNtothenate Kinase
type: ProteinReference
xref: uniprot H2KYP7 89
organism: Caenorhabditis elegans

Pantothenate kinase 1
type: ProteinReference
xref: uniprot Q8TE04 102
organism: Homo sapiens

uniprot Q8RHR7 60
type: UnificationXref
id: Q8RHR7
db: uniprot

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot Q9VI57 68
organism: Drosophila melanogaster

Pantetheine-phosphate adenyltransferase
type: Protein
entity reference: Pantetheine-phosphate adenyltransferase
comment: SPECIES_TYPE=PROTEIN

dephospho-Coenzyme-A
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 32

Coenzyme A biosynthesis bifunctional protein CoaBC
type: ProteinReference
xref: uniprot Q8CK27 16
organism: Streptomyces coelicolor

uniprot O74414 44
type: UnificationXref
id: O74414
db: uniprot

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot Q8RHR7 60
organism: Fusobacterium nucleatum

Mus musculus
type: BioSource
xref: ncbitaxon 10090 26

uniprot P34558 48
type: UnificationXref
id: P34558
db: uniprot

uniprot O74962 91
type: UnificationXref
id: O74962
db: uniprot

P02886
type: UnificationXref
id: P02886
db: PANTHER Pathway Component

uniprot Q80YV4 98
type: UnificationXref
id: Q80YV4
db: uniprot

uniprot Q04430 92
type: UnificationXref
id: Q04430
db: uniprot

uniprot Q7QA58 57
type: UnificationXref
id: Q7QA58
db: uniprot

uniprot D3ZWD3 79
type: UnificationXref
id: D3ZWD3
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 53

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 55

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 69

uniprot A8XA56 38
type: UnificationXref
id: A8XA56
db: uniprot

AGAP010073-PA
type: ProteinReference
xref: uniprot Q7Q0Y3 97
organism: Anopheles gambiae

ncbitaxon 251221 11
type: UnificationXref
id: 251221
db: ncbitaxon

Uncharacterized protein C14G10.01
type: ProteinReference
xref: uniprot O74414 44
organism: Schizosaccharomyces pombe

4-phosphopantothenate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8R2W9 101
type: UnificationXref
id: Q8R2W9
db: uniprot

Pantothenate cysteine ligase
type: Protein
entity reference: Pantothenate cysteine ligase
comment: SPECIES_TYPE=PROTEIN

uniprot Q923S8 104
type: UnificationXref
id: Q923S8
db: uniprot

uniprot P9WPA3 50
type: UnificationXref
id: P9WPA3
db: uniprot

ncbitaxon 39947 63
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot F1LT70 81
type: UnificationXref
id: F1LT70
db: uniprot

uniprot P94063 33
type: UnificationXref
id: P94063
db: uniprot

uniprot Q9HVP8 64
type: UnificationXref
id: Q9HVP8
db: uniprot

uniprot Q8TK70 117
type: UnificationXref
id: Q8TK70
db: uniprot

PARTICIPANT STOICHIOMETRY r1 133
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 126
type: Stoichiometry
physical entity: 4-phosphopantothenate
stoichiometric coefficient: 1.0

uniprot Q9RWT6 29
type: UnificationXref
id: Q9RWT6
db: uniprot

PARTICIPANT STOICHIOMETRY r2 125
type: Stoichiometry
physical entity: CTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 131
type: Stoichiometry
physical entity: pantothenate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 124
type: Stoichiometry
physical entity: cysteine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 132
type: Stoichiometry
physical entity: 4-phosphopantothenate
stoichiometric coefficient: 1.0

Pantothenate kinase 4
type: ProteinReference
xref: uniprot Q80YV4 98
organism: Mus musculus

uniprot D4A6X7 2
type: UnificationXref
id: D4A6X7
db: uniprot

PARTICIPANT STOICHIOMETRY r1 130
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot O34932 42
type: UnificationXref
id: O34932
db: uniprot

uniprot A0A452DI42 36
type: UnificationXref
id: A0A452DI42
db: uniprot

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot P0A6I9 46
organism: Escherichia coli

DCAKD isoform 1
type: ProteinReference
xref: uniprot H2QD83 40
organism: Pan troglodytes

uniprot Q9RWM4 118
type: UnificationXref
id: Q9RWM4
db: uniprot

uniprot O35033 6
type: UnificationXref
id: O35033
db: uniprot

uniprot Q8A812 14
type: UnificationXref
id: Q8A812
db: uniprot

Pantothenate kinase 1
type: ProteinReference
xref: uniprot E1BCR9 80
organism: Bos taurus

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 15

Pantothenate kinase 3
type: ProteinReference
xref: uniprot Q8R2W9 101
organism: Mus musculus

Phosphopantothenoylcysteine synthetase
type: ProteinReference
xref: uniprot D4A6X7 2
organism: Rattus norvegicus

uniprot O34797 110
type: UnificationXref
id: O34797
db: uniprot

uniprot H2QD83 40
type: UnificationXref
id: H2QD83
db: uniprot

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot Q9HVP8 64
organism: Pseudomonas aeruginosa

PARTICIPANT STOICHIOMETRY r2 129
type: Stoichiometry
physical entity: 4-phospho-N-pantothenoylcysteine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 127
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 128
type: Stoichiometry
physical entity: CMP
stoichiometric coefficient: 1.0

4-phospho-N-pantothenoylcysteine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9NVE7 108
type: UnificationXref
id: Q9NVE7
db: uniprot

uniprot A0A2I3RH50 72
type: UnificationXref
id: A0A2I3RH50
db: uniprot

Probable phosphopantothenoylcysteine decarboxylase
type: ProteinReference
xref: uniprot P94063 33
organism: Arabidopsis thaliana

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 45

uniprot Q8TRA0 23
type: UnificationXref
id: Q8TRA0
db: uniprot

Dephospho-CoA kinase
type: ProteinReference
xref: P02884
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Coenzyme A biosynthesis.PROTEIN.GENERIC.Dephospho-CoA_br_kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: Dephospho-CoA kinase Synonym: Synonym not specified Accession: P02884
member entity reference: Uncharacterized protein C14G10.01
member entity reference: Dephospho-CoA kinase
member entity reference: Protein CBG10005
member entity reference: Dephospho-CoA kinase domain-containing protein
member entity reference: Dephospho-CoA kinase CAB5
member entity reference: DCAKD isoform 1
member entity reference: AGAP004425-PA
member entity reference: Uncharacterized protein T05G5.5

Pantothenate kinase 4
type: ProteinReference
xref: uniprot Q923S8 104
organism: Rattus norvegicus

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot Q9RWM4 118
organism: Deinococcus radiodurans

uniprot Q9SWE5 35
type: UnificationXref
id: Q9SWE5
db: uniprot

uniprot O66614 111
type: UnificationXref
id: O66614
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 41

Pantothenate kinase 2
type: ProteinReference
xref: uniprot F1MX42 83
organism: Bos taurus

ncbitaxon 7165 58
type: UnificationXref
id: 7165
db: ncbitaxon

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 78

uniprot Q9S2K7 67
type: UnificationXref
id: Q9S2K7
db: uniprot

Pantothenate kinase
type: ProteinReference
xref: uniprot Q18580 94
organism: Caenorhabditis elegans

uniprot Q7NKD0 10
type: UnificationXref
id: Q7NKD0
db: uniprot

Phosphopantothenate--cysteine ligase
type: ProteinReference
xref: uniprot Q9HAB8 27
organism: Homo sapiens

uniprot Q8CK27 16
type: UnificationXref
id: Q8CK27
db: uniprot

uniprot Q8A3C0 114
type: UnificationXref
id: Q8A3C0
db: uniprot

Coenzyme A biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__ATP-_dephospho_Coenzyme_A-RIGHT__Coenzyme_A-_ADP-_r5
pathway component: STATE_TRANSITION_LEFT__ATP-_pantothenate-RIGHT__4_phosphopantothenate-_ADP-_r1
pathway component: STATE_TRANSITION_LEFT__4_phospho_N_pantothenoylcysteine-RIGHT__CO2-_pantetheine_4_phosphate-_r3
pathway component: STATE_TRANSITION_LEFT__ATP-_pantetheine_4_phosphate-RIGHT__dephospho_Coenzyme_A-_PPi-_r4
pathway component: STATE_TRANSITION_LEFT__cysteine-_CTP-_4_phosphopantothenate-RIGHT__PPi-_CMP-_4_phospho_N_pantothenoylcysteine-_r2
xref: PANTHER Pathway P02736 1
comment: MODEL_NOTES=The biosynthesis of Coenzyme A. Coenzyme A functions in metabolism as a carrier and transporter of acyl groups. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

ncbitaxon 9598 41
type: UnificationXref
id: 9598
db: ncbitaxon

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot Q9ZBR1 120
organism: Streptomyces coelicolor

STATE_TRANSITION_LEFT__4_phospho_N_pantothenoylcysteine-RIGHT__CO2-_pantetheine_4_phosphate-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 122
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 121
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 123
left: 4-phospho-N-pantothenoylcysteine
interaction type: STATE_TRANSITION
right: pantetheine-4-phosphate
right: CO2

Uncharacterized protein
type: ProteinReference
xref: uniprot G5EAY3 87
organism: Emericella nidulans

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 19

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 30

Pantothenate kinase 2, mitochondrial
type: ProteinReference
xref: uniprot Q9BZ23 105
organism: Homo sapiens

uniprot F6ZGL8 4
type: UnificationXref
id: F6ZGL8
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 28

uniprot H2KYP7 89
type: UnificationXref
id: H2KYP7
db: uniprot

Pantothenoylcysteine decarboxylase
type: Protein
entity reference: Pantothenoylcysteine decarboxylase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 224324 9
type: UnificationXref
id: 224324
db: ncbitaxon

uniprot Q9VMU2 109
type: UnificationXref
id: Q9VMU2
db: uniprot

Dephospho-CoA kinase domain-containing protein
type: ProteinReference
xref: uniprot A0A452DI42 36
organism: Bos taurus

Dephospho-CoA kinase CAB5
type: ProteinReference
xref: uniprot Q03941 52
organism: Saccharomyces cerevisiae

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot Q9ZQH0 70
organism: Arabidopsis thaliana

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 34

uniprot F7FW50 84
type: UnificationXref
id: F7FW50
db: uniprot

STATE_TRANSITION_LEFT__ATP-_pantetheine_4_phosphate-RIGHT__dephospho_Coenzyme_A-_PPi-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 139
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 140
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 141
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 138
left: pantetheine-4-phosphate
left: ATP
interaction type: STATE_TRANSITION
right: dephospho-Coenzyme-A
right: PPi

Fumble
type: ProteinReference
xref: uniprot Q9NHN2 107
organism: Drosophila melanogaster

uniprot F7GTZ5 85
type: UnificationXref
id: F7GTZ5
db: uniprot

ncbitaxon 227321 88
type: UnificationXref
id: 227321
db: ncbitaxon

Probable coenzyme A biosynthesis bifunctional protein CoaBC
type: ProteinReference
xref: uniprot O35033 6
organism: Bacillus subtilis

ncbitaxon 559292 53
type: UnificationXref
id: 559292
db: ncbitaxon

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot O66614 111
organism: Aquifex aeolicus

DNA/pantothenate metabolism flavoprotein
type: ProteinReference
xref: uniprot Q8EZC0 20
organism: Leptospira interrogans

Pantothenate kinase 2
type: ProteinReference
xref: uniprot F1LT70 81
organism: Rattus norvegicus

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8WVC6 61
type: UnificationXref
id: Q8WVC6
db: uniprot

ncbitaxon 7227 69
type: UnificationXref
id: 7227
db: ncbitaxon

Phosphopantothenoylcysteine decarboxylase
type: ProteinReference
xref: uniprot Q9SWE5 35
organism: Arabidopsis thaliana

uniprot Q8TE04 102
type: UnificationXref
id: Q8TE04
db: uniprot

Pantothenate kinase 2
type: ProteinReference
xref: uniprot Q8L5Y9 100
organism: Arabidopsis thaliana

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 51

Pantothenate kinase CAB1
type: ProteinReference
xref: uniprot Q04430 92
organism: Saccharomyces cerevisiae

pantothenate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Coenzyme A biosynthesis bifunctional protein CoaBC
type: ProteinReference
xref: uniprot Q7NKD0 10
organism: Gloeobacter violaceus

uniprot Q8RFI5 21
type: UnificationXref
id: Q8RFI5
db: uniprot

uniprot F7GV14 86
type: UnificationXref
id: F7GV14
db: uniprot

Coenzyme-A
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9031 75
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot Q8EZC0 20
type: UnificationXref
id: Q8EZC0
db: uniprot

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 47

AGAP004425-PA
type: ProteinReference
xref: uniprot Q7QA58 57
organism: Anopheles gambiae

uniprot A0A1D5Q4M5 71
type: UnificationXref
id: A0A1D5Q4M5
db: uniprot

Flavoprotein
type: ProteinReference
xref: uniprot Q8EZB9 18
organism: Leptospira interrogans

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot P9WPA3 50
organism: Mycobacterium tuberculosis

uniprot Q3U4S0 95
type: UnificationXref
id: Q3U4S0
db: uniprot

Pantothenate kinase 4
type: ProteinReference
xref: uniprot F1MLD0 82
organism: Bos taurus

Protein CBG10005
type: ProteinReference
xref: uniprot A8XA56 38
organism: Caenorhabditis briggsae

ncbitaxon 1111708 55
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot Q8RGX1 116
type: UnificationXref
id: Q8RGX1
db: uniprot

Uncharacterized protein, isoform A
type: ProteinReference
xref: uniprot Q9VMU2 109
organism: Drosophila melanogaster

uniprot Q9X213 31
type: UnificationXref
id: Q9X213
db: uniprot

STATE_TRANSITION_LEFT__ATP-_pantothenate-RIGHT__4_phosphopantothenate-_ADP-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 133
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 132
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 131
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 130
left: pantothenate
left: ATP
interaction type: STATE_TRANSITION
right: 4-phosphopantothenate
right: ADP

ncbitaxon 243274 32
type: UnificationXref
id: 243274
db: ncbitaxon

uniprot Q7UKG6 113
type: UnificationXref
id: Q7UKG6
db: uniprot

uniprot F1MX42 83
type: UnificationXref
id: F1MX42
db: uniprot

uniprot Q08DA5 93
type: UnificationXref
id: Q08DA5
db: uniprot

uniprot Q8L5Y9 100
type: UnificationXref
id: Q8L5Y9
db: uniprot

PARTICIPANT STOICHIOMETRY r4 138
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 139
type: Stoichiometry
physical entity: pantetheine-4-phosphate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__cysteine-_CTP-_4_phosphopantothenate-RIGHT__PPi-_CMP-_4_phospho_N_pantothenoylcysteine-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 124
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 127
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 126
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 129
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 128
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 125
left: CTP
left: 4-phosphopantothenate
left: cysteine
interaction type: STATE_TRANSITION
right: CMP
right: 4-phospho-N-pantothenoylcysteine
right: PPi

uniprot O66997 8
type: UnificationXref
id: O66997
db: uniprot

uniprot Q8EYP6 115
type: UnificationXref
id: Q8EYP6
db: uniprot

Coenzyme A biosynthesis bifunctional protein CoaBC
type: ProteinReference
xref: uniprot Q8TRA0 23
organism: Methanosarcina acetivorans

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2R312 90
type: UnificationXref
id: H2R312
db: uniprot

uniprot Q18580 94
type: UnificationXref
id: Q18580
db: uniprot

uniprot Q03941 52
type: UnificationXref
id: Q03941
db: uniprot

uniprot Q9ZQH0 70
type: UnificationXref
id: Q9ZQH0
db: uniprot

Pantothenate kinase
type: ProteinReference
xref: P02885
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Coenzyme A biosynthesis.PROTEIN.GENERIC.Pantothenate_br_kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: Pantothenate kinase Synonym: Synonym not specified Accession: P02885
member entity reference: Pantothenate kinase 3
member entity reference: Fumble
member entity reference: Pantothenate kinase 2
member entity reference: AGAP011715-PA (Fragment)
member entity reference: Pantothenate kinase 1
member entity reference: Pantothenate kinase CAB1
member entity reference: Uncharacterized protein
member entity reference: Pantothenate kinase 4
member entity reference: AGAP010073-PA
member entity reference: Pantothenate kinase
member entity reference: At4g35360/F23E12_80
member entity reference: Protein CBR-PNK-1
member entity reference: PANK2 isoform 3
member entity reference: PANK1 isoform 1
member entity reference: LOC100135204 protein
member entity reference: Uncharacterized protein, isoform A
member entity reference: Pantothenate kinase 2, mitochondrial
member entity reference: PaNtothenate Kinase

uniprot Q9BZ23 105
type: UnificationXref
id: Q9BZ23
db: uniprot

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 7

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 22

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot Q7UKG6 113
organism: Rhodopirellula baltica

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot O67792 43
organism: Aquifex aeolicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_pantetheine_4_phosphate-RIGHT__dephospho_Coenzyme_A-_PPi-_r4
controller: Pantetheine-phosphate adenyltransferase

Bos taurus
type: BioSource
xref: ncbitaxon 9913 37

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 5

uniprot Q8BHC4 59
type: UnificationXref
id: Q8BHC4
db: uniprot

uniprot Q8K4K6 99
type: UnificationXref
id: Q8K4K6
db: uniprot

Dephospho-CoA kinase
type: Protein
entity reference: Dephospho-CoA kinase
comment: SPECIES_TYPE=PROTEIN

Coenzyme A biosynthesis bifunctional protein CoaBC
type: ProteinReference
xref: uniprot Q9X213 31
organism: Thermotoga maritima

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FW50 84
organism: Macaca mulatta

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot Q9S2K7 67
organism: Streptomyces coelicolor

uniprot Q9ZBR1 120
type: UnificationXref
id: Q9ZBR1
db: uniprot

Pantothenate cysteine ligase
type: ProteinReference
xref: P02882
standard name: Phosphopantothenate cysteine ligase
comment: ENTITY_REFERENCE_ID_DESC=Coenzyme A biosynthesis.PROTEIN.GENERIC.Pantothenate_br_cysteine ligase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphopantothenate cysteine ligase Synonym: Synonym not specified Accession: P02882
member entity reference: Coenzyme A biosynthesis bifunctional protein CoaBC
member entity reference: Phosphopantothenate--cysteine ligase
member entity reference: Phosphopantothenoylcysteine synthetase
member entity reference: Flavoprotein
member entity reference: DNA/pantothenate metabolism flavoprotein
member entity reference: Probable coenzyme A biosynthesis bifunctional protein CoaBC
member entity reference: Uncharacterized protein

Pantothenate kinase 1
type: ProteinReference
xref: uniprot D3ZWD3 79
organism: Rattus norvegicus

Protein CBR-PNK-1
type: ProteinReference
xref: uniprot A8XG37 76
organism: Caenorhabditis briggsae

DNA/pantothenate metabolism flavoprotein
type: ProteinReference
xref: uniprot Q7UP94 12
organism: Rhodopirellula baltica

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GV14 86
organism: Macaca mulatta

ncbitaxon 243230 30
type: UnificationXref
id: 243230
db: ncbitaxon

uniprot E1BCR9 80
type: UnificationXref
id: E1BCR9
db: uniprot

Pantothenate kinase 1
type: ProteinReference
xref: uniprot Q8K4K6 99
organism: Mus musculus

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 24

Pantothenate kinase
type: Protein
entity reference: Pantothenate kinase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 10116 3
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot Q55515 54
type: UnificationXref
id: Q55515
db: uniprot

AGAP011715-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PVC2 96
organism: Anopheles gambiae

Dephospho-CoA kinase domain-containing protein
type: ProteinReference
xref: uniprot Q6AY55 56
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5Q4M5 71
organism: Macaca mulatta

uniprot Q7PVC2 96
type: UnificationXref
id: Q7PVC2
db: uniprot

uniprot G5EAY3 87
type: UnificationXref
id: G5EAY3
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 3

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 9

ncbitaxon 189518 19
type: UnificationXref
id: 189518
db: ncbitaxon

LOC100135204 protein
type: ProteinReference
xref: uniprot A9ULG9 77
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_pantothenate-RIGHT__4_phosphopantothenate-_ADP-_r1
controller: Pantothenate kinase

Pantetheine-phosphate adenyltransferase
type: ProteinReference
xref: P02886
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Coenzyme A biosynthesis.PROTEIN.GENERIC.Pantetheine-phosphate_br_adenyltransferase
comment: ENTITY_REFERENCE_NOTES=Long Name: Pantetheine-phosphate adenyltransferase Synonym: Synonym not specified Accession: P02886
member entity reference: Phosphopantetheine adenylyltransferase

ncbitaxon 243090 13
type: UnificationXref
id: 243090
db: ncbitaxon

Pantothenate kinase 3
type: ProteinReference
xref: uniprot A0A3Q2U8Y9 74
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r4 141
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

Dephospho-CoA kinase domain-containing protein
type: ProteinReference
xref: uniprot Q8BHC4 59
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r4 140
type: Stoichiometry
physical entity: dephospho-Coenzyme-A
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_dephospho_Coenzyme_A-RIGHT__Coenzyme_A-_ADP-_r5
controller: Dephospho-CoA kinase

uniprot Q7UP94 12
type: UnificationXref
id: Q7UP94
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 75

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot Q8RGX1 116
organism: Fusobacterium nucleatum

uniprot Q9NHN2 107
type: UnificationXref
id: Q9NHN2
db: uniprot

ncbitaxon 3702 34
type: UnificationXref
id: 3702
db: ncbitaxon

ncbitaxon 284812 45
type: UnificationXref
id: 284812
db: ncbitaxon

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot O34797 110
organism: Bacillus subtilis

ncbitaxon 188937 24
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot A0A2I3SAC6 73
type: UnificationXref
id: A0A2I3SAC6
db: uniprot

At4g35360/F23E12_80
type: ProteinReference
xref: uniprot Q8W4Q1 103
organism: Arabidopsis thaliana

Rhodopirellula baltica
type: BioSource
xref: ncbitaxon 243090 13

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 17

ncbitaxon 8364 78
type: UnificationXref
id: 8364
db: ncbitaxon

ncbitaxon 9913 37
type: UnificationXref
id: 9913
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__cysteine-_CTP-_4_phosphopantothenate-RIGHT__PPi-_CMP-_4_phospho_N_pantothenoylcysteine-_r2
controller: Pantothenate cysteine ligase

PARTICIPANT STOICHIOMETRY r3 123
type: Stoichiometry
physical entity: pantetheine-4-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 122
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 121
type: Stoichiometry
physical entity: 4-phospho-N-pantothenoylcysteine
stoichiometric coefficient: 1.0

Pantothenate kinase 3
type: ProteinReference
xref: uniprot Q9H999 106
organism: Homo sapiens

ncbitaxon 190304 22
type: UnificationXref
id: 190304
db: ncbitaxon

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot Q9RT73 66
organism: Deinococcus radiodurans

Coenzyme A biosynthesis bifunctional protein CoaBC
type: ProteinReference
xref: uniprot Q8A812 14
organism: Bacteroides thetaiotaomicron

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION
type: InteractionVocabulary

Dephospho-CoA kinase domain-containing protein
type: ProteinReference
xref: uniprot Q8WVC6 61
organism: Homo sapiens

Pantothenoylcysteine decarboxylase
type: ProteinReference
xref: P02883
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Pantothenoylcysteine decarboxylase Synonym: Synonym not specified Accession: P02883
comment: ENTITY_REFERENCE_ID_DESC=Coenzyme A biosynthesis.PROTEIN.GENERIC.Pantothenoylcysteine_br_decarboxylase
member entity reference: Probable phosphopantothenoylcysteine decarboxylase
member entity reference: Coenzyme A biosynthesis bifunctional protein CoaBC
member entity reference: Flavoprotein
member entity reference: DNA/pantothenate metabolism flavoprotein
member entity reference: Phosphopantothenoylcysteine decarboxylase
member entity reference: Probable coenzyme A biosynthesis bifunctional protein CoaBC

STATE_TRANSITION_LEFT__ATP-_dephospho_Coenzyme_A-RIGHT__Coenzyme_A-_ADP-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 137
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 136
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 135
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 134
left: dephospho-Coenzyme-A
left: ATP
interaction type: STATE_TRANSITION
right: Coenzyme-A
right: ADP

Coenzyme A biosynthesis bifunctional protein CoaBC
type: ProteinReference
xref: uniprot Q9RWT6 29
organism: Deinococcus radiodurans

uniprot Q94DR2 62
type: UnificationXref
id: Q94DR2
db: uniprot

ncbitaxon 100226 17
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot O67792 43
type: UnificationXref
id: O67792
db: uniprot

ncbitaxon 224308 7
type: UnificationXref
id: 224308
db: ncbitaxon

uniprot Q9HAB8 27
type: UnificationXref
id: Q9HAB8
db: uniprot

CMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A3Q2U8Y9 74
type: UnificationXref
id: A0A3Q2U8Y9
db: uniprot

uniprot Q7Q0Y3 97
type: UnificationXref
id: Q7Q0Y3
db: uniprot

uniprot Q6AY55 56
type: UnificationXref
id: Q6AY55
db: uniprot

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9H999 106
type: UnificationXref
id: Q9H999
db: uniprot

uniprot Q9RT73 66
type: UnificationXref
id: Q9RT73
db: uniprot

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot Q7NMB9 112
organism: Gloeobacter violaceus

ncbitaxon 208964 65
type: UnificationXref
id: 208964
db: ncbitaxon

uniprot Q9VI57 68
type: UnificationXref
id: Q9VI57
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZGL8 4
organism: Macaca mulatta

Pantothenate kinase 2
type: ProteinReference
xref: uniprot Q3U4S0 95
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r5 134
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Pantothenate kinase
type: ProteinReference
xref: uniprot O74962 91
organism: Schizosaccharomyces pombe

ncbitaxon 10090 26
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot A8XG37 76
type: UnificationXref
id: A8XG37
db: uniprot

Uncharacterized protein T05G5.5
type: ProteinReference
xref: uniprot P34558 48
organism: Caenorhabditis elegans

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 39

cysteine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 49

PARTICIPANT STOICHIOMETRY r5 135
type: Stoichiometry
physical entity: dephospho-Coenzyme-A
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 136
type: Stoichiometry
physical entity: Coenzyme-A
stoichiometric coefficient: 1.0

PANK2 isoform 3
type: ProteinReference
xref: uniprot H2R312 90
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r5 137
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Coenzyme A biosynthesis bifunctional protein CoaBC
type: ProteinReference
xref: uniprot Q8RFI5 21
organism: Fusobacterium nucleatum

ncbitaxon 226186 15
type: UnificationXref
id: 226186
db: ncbitaxon

P02882
type: UnificationXref
id: P02882
db: PANTHER Pathway Component

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot O34932 42
organism: Bacillus subtilis

P02883
type: UnificationXref
id: P02883
db: PANTHER Pathway Component

P02884
type: UnificationXref
id: P02884
db: PANTHER Pathway Component

P02885
type: UnificationXref
id: P02885
db: PANTHER Pathway Component

uniprot P0A6I9 46
type: UnificationXref
id: P0A6I9
db: uniprot

Pantothenate kinase 3
type: ProteinReference
xref: uniprot A0A2I3RH50 72
organism: Pan troglodytes

Phosphopantothenate--cysteine ligase
type: ProteinReference
xref: uniprot Q8VDG5 25
organism: Mus musculus

ncbitaxon 83333 47
type: UnificationXref
id: 83333
db: ncbitaxon

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot Q55515 54
organism: Synechocystis

Dephospho-CoA kinase
type: ProteinReference
xref: uniprot Q94DR2 62
organism: Oryza sativa

Phosphopantetheine adenylyltransferase
type: ProteinReference
xref: uniprot Q8A3C0 114
organism: Bacteroides thetaiotaomicron

uniprot Q8W4Q1 103
type: UnificationXref
id: Q8W4Q1
db: uniprot

ncbitaxon 9544 5
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot Q8EZB9 18
type: UnificationXref
id: Q8EZB9
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 63

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 88

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 65

Coenzyme A biosynthesis bifunctional protein CoaBC
type: ProteinReference
xref: uniprot O66997 8
organism: Aquifex aeolicus

PANTHER Pathway P02736 1
type: UnificationXref
id: P02736
db: PANTHER Pathway

ncbitaxon 83332 51
type: UnificationXref
id: 83332
db: ncbitaxon

pantetheine-4-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F1MLD0 82
type: UnificationXref
id: F1MLD0
db: uniprot

CTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE