PTHR11937:SF411
type: RelationshipXref
id: PTHR11937:SF411
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Cdc42_GTP_-RIGHT__Pi-_Complex__GDP_Cdc42_-_r17
controller: Rho GAPs

Actin, aortic smooth muscle
type: ProteinReference
xref: uniprot F1P476 245
xref: PTHR11937:SF201
organism: Gallus gallus

uniprot F6T2E7 463
type: UnificationXref
id: F6T2E7
db: uniprot

uniprot A8XS95 199
type: UnificationXref
id: A8XS95
db: uniprot

PTHR11937:SF414
type: RelationshipXref
id: PTHR11937:SF414
db: PANTHER Family
relationship type: By Homology

Rac family small GTPase 3
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot F6THF0 682
organism: Monodelphis domestica

PTHR11937:SF410
type: RelationshipXref
id: PTHR11937:SF410
db: PANTHER Family
relationship type: By Homology

Rho-associated protein kinase let-502
type: ProteinReference
xref: uniprot P92199 510
organism: Caenorhabditis elegans

uniprot A8JAV1 194
type: UnificationXref
id: A8JAV1
db: uniprot

Myosin-7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot A2AQP0 579
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q17QZ0 483
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E1BS97 455
xref: PTHR48015:SF22
organism: Gallus gallus

uniprot H2QK55 406
type: UnificationXref
id: H2QK55
db: uniprot

Profilin
type: ProteinReference
xref: uniprot P07274 543
organism: Saccharomyces cerevisiae

uniprot F1MM57 592
type: UnificationXref
id: F1MM57
db: uniprot

uniprot Q96292 374
type: UnificationXref
id: Q96292
db: uniprot

PTHR11588:SF395
type: RelationshipXref
id: PTHR11588:SF395
db: PANTHER Family
relationship type: By Homology

uniprot F7A7I3 262
type: UnificationXref
id: F7A7I3
db: uniprot

CFL1 isoform 2
type: ProteinReference
xref: uniprot A0A2I3TDQ7 51
organism: Pan troglodytes

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot F4NUL6 764
organism: Batrachochytrium dendrobatidis

PTHR11937:SF408
type: RelationshipXref
id: PTHR11937:SF408
db: PANTHER Family
relationship type: By Homology

uniprot Q9Y623 673
type: UnificationXref
id: Q9Y623
db: uniprot

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__ARP2_3-_N_WASP-RIGHT__Complex__N_WASP_ARP2__3_-_r48
controller: Complex (Cdc42/GTP)

uniprot A2HNG1 183
type: UnificationXref
id: A2HNG1
db: uniprot

uniprot Q28824 411
type: UnificationXref
id: Q28824
db: uniprot

Protein diaphanous homolog 3
type: ProteinReference
xref: uniprot Q9Z207 83
organism: Mus musculus

uniprot A9TBG2 202
type: UnificationXref
id: A9TBG2
db: uniprot

uniprot E1BX17 402
type: UnificationXref
id: E1BX17
db: uniprot

uniprot C3XYD4 225
type: UnificationXref
id: C3XYD4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZYS7 388
organism: Macaca mulatta

uniprot P99024 823
type: UnificationXref
id: P99024
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 40

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q7ZWH4 159
xref: PTHR12644:SF1
organism: Danio rerio

Profilin
type: ProteinReference
xref: uniprot F6Q4N4 535
organism: Ornithorhynchus anatinus

uniprot P59998 138
type: UnificationXref
id: P59998
db: uniprot

ncbitaxon 54126 179
type: UnificationXref
id: 54126
db: ncbitaxon

Rho-related GTP-binding protein RhoU
type: ProteinReference
xref: uniprot Q7L0Q8 431
organism: Homo sapiens

Myosin heavy chain 9
type: ProteinReference
xref: uniprot F6RH86 609
organism: Ornithorhynchus anatinus

uniprot H2QB15 405
type: UnificationXref
id: H2QB15
db: uniprot

Predicted protein
type: ProteinReference
xref: uniprot A7S9Y5 10
xref: PTHR24072:SF168
organism: Nematostella vectensis

ncbitaxon 3702 125
type: UnificationXref
id: 3702
db: ncbitaxon

Tubulin beta chain
type: ProteinReference
xref: uniprot C3Y3Q1 751
xref: PTHR11588:SF89
organism: Branchiostoma floridae

uniprot Q6DGB7 698
type: UnificationXref
id: Q6DGB7
db: uniprot

uniprot A0A2I3TC58 727
type: UnificationXref
id: A0A2I3TC58
db: uniprot

uniprot H3F5B4 276
type: UnificationXref
id: H3F5B4
db: uniprot

uniprot F7GWI2 472
type: UnificationXref
id: F7GWI2
db: uniprot

PTHR11588:SF376
type: RelationshipXref
id: PTHR11588:SF376
db: PANTHER Family
relationship type: By Homology

PTHR11588:SF375
type: RelationshipXref
id: PTHR11588:SF375
db: PANTHER Family
relationship type: By Homology

Actin related protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A8BV70 192
organism: Giardia intestinalis

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF2
xref: uniprot F7BD45 617
organism: Monodelphis domestica

uniprot F7G2Y1 504
type: UnificationXref
id: F7G2Y1
db: uniprot

uniprot H3DZP2 786
type: UnificationXref
id: H3DZP2
db: uniprot

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: uniprot A0A1D5RJ31 84
xref: PTHR12058:SF0
organism: Macaca mulatta

uniprot Q6NVA9 357
type: UnificationXref
id: Q6NVA9
db: uniprot

Cytoplasmatic actin
type: ProteinReference
xref: uniprot E9FXV8 239
xref: PTHR11937:SF387
organism: Daphnia pulex

Predicted protein
type: ProteinReference
xref: uniprot A7S0V7 188
xref: PTHR11937:SF387
organism: Nematostella vectensis

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 331

ncbitaxon 8364 67
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot Q4QBZ6 840
type: UnificationXref
id: Q4QBZ6
db: uniprot

uniprot P85108 822
type: UnificationXref
id: P85108
db: uniprot

uniprot P32882 811
type: UnificationXref
id: P32882
db: uniprot

PTHR11588:SF389
type: RelationshipXref
id: PTHR11588:SF389
db: PANTHER Family
relationship type: By Homology

uniprot O45815 279
type: UnificationXref
id: O45815
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot P85970 141
organism: Rattus norvegicus

uniprot P70429 443
type: UnificationXref
id: P70429
db: uniprot

uniprot Q3KRE8 832
type: UnificationXref
id: Q3KRE8
db: uniprot

STATE_TRANSITION_LEFT__MLCK-RIGHT__MLCK-_r44
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 954
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 955
left: MLCK
interaction type: STATE_TRANSITION
right: MLCK

uniprot Q6NW90 849
type: UnificationXref
id: Q6NW90
db: uniprot

tubulin s52 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: tubulin
stoichiometric coefficient: 2.0

Wiskott-Aldrich syndrome like
type: ProteinReference
xref: uniprot F7E2I0 719
xref: PTHR23202:SF39
organism: Ornithorhynchus anatinus

Neural Wiskott-Aldrich syndrome protein
type: ProteinReference
xref: uniprot A0A1D5RB13 716
xref: PTHR23202:SF39
organism: Macaca mulatta

uniprot E1BC64 708
type: UnificationXref
id: E1BC64
db: uniprot

Profilin
type: ProteinReference
xref: uniprot F6T2V7 536
organism: Monodelphis domestica

LIMK
type: Protein
entity reference: LIMK
feature: T508 LIMK s33 a48 rs1
feature: ACTIVE 48
comment: SPECIES_TYPE=PROTEIN

uniprot Q95107 723
type: UnificationXref
id: Q95107
db: uniprot

STATE_TRANSITION_LEFT__Complex__Rac_GTP_-RIGHT__Pi-_Complex__GDP_Rac_-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 948
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 947
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 946
left: Complex (Rac/GTP)
interaction type: STATE_TRANSITION
right: Pi
right: Complex (GDP/Rac)

uniprot B7PBG2 215
type: UnificationXref
id: B7PBG2
db: uniprot

uniprot Q9Z1I6 498
type: UnificationXref
id: Q9Z1I6
db: uniprot

uniprot Q6P367 850
type: UnificationXref
id: Q6P367
db: uniprot

PTHR11937:SF453
type: RelationshipXref
id: PTHR11937:SF453
db: PANTHER Family
relationship type: By Homology

uniprot A0A3Q1LSY0 448
type: UnificationXref
id: A0A3Q1LSY0
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF389
xref: uniprot Q6XNL8 362
organism: Danio rerio

Tubulin beta-4B chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot P68372 819
organism: Mus musculus

Tubulin beta-4B chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot P68371 818
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0JP99 450
organism: Xenopus tropicalis

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF314
xref: uniprot Q6P367 850
organism: Xenopus tropicalis

uniprot E9FRT1 238
type: UnificationXref
id: E9FRT1
db: uniprot

Tubulin beta-4 chain
type: ProteinReference
xref: PTHR11588:SF329
xref: uniprot P24636 807
organism: Arabidopsis thaliana

Tubulin beta-5 chain
type: ProteinReference
xref: uniprot Q2KJD0 830
xref: PTHR11588:SF61
organism: Bos taurus

uniprot Q13177 481
type: UnificationXref
id: Q13177
db: uniprot

uniprot H2QC97 626
type: UnificationXref
id: H2QC97
db: uniprot

Diaphanous related formin 2
type: ProteinReference
xref: uniprot A0A2I3RZA9 75
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r48 942
type: Stoichiometry
physical entity: Complex (N-WASP/ARP2/ 3)
stoichiometric coefficient: 1.0

PTHR11937:SF446
type: RelationshipXref
id: PTHR11937:SF446
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r48 940
type: Stoichiometry
physical entity: ARP2/3
stoichiometric coefficient: 1.0

PTHR11937:SF445
type: RelationshipXref
id: PTHR11937:SF445
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r48 941
type: Stoichiometry
physical entity: N-WASP
stoichiometric coefficient: 1.0

uniprot W4X9L8 875
type: UnificationXref
id: W4X9L8
db: uniprot

Cdc42 s14 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

Rac family small GTPase 3a
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot Q6DGB7 698
organism: Danio rerio

uniprot P68136 327
type: UnificationXref
id: P68136
db: uniprot

ncbitaxon 7739 95
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot F6Y6B5 523
type: UnificationXref
id: F6Y6B5
db: uniprot

uniprot Q29RW1 654
type: UnificationXref
id: Q29RW1
db: uniprot

uniprot B7PHY7 416
type: UnificationXref
id: B7PHY7
db: uniprot

PTHR11937:SF438
type: RelationshipXref
id: PTHR11937:SF438
db: PANTHER Family
relationship type: By Homology

uniprot H2QV01 116
type: UnificationXref
id: H2QV01
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot Q6P378 358
organism: Xenopus tropicalis

Profilin
type: ProteinReference
xref: uniprot Q5ZL50 560
organism: Gallus gallus

Protein phosphatase Slingshot homolog 1
type: ProteinReference
xref: uniprot Q8WYL5 74
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F0ZK40 243
xref: PTHR11937:SF154
organism: Dictyostelium purpureum

Actin-7
type: ProteinReference
xref: uniprot P0C540 285
xref: PTHR11937:SF408
organism: Oryza sativa

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot F6QTB5 104
organism: Ornithorhynchus anatinus

PTHR11937:SF430
type: RelationshipXref
id: PTHR11937:SF430
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF2
xref: uniprot F1P3X1 598
organism: Gallus gallus

Myosin, heavy chain 10, non-muscle
type: ProteinReference
xref: uniprot F1R3G4 605
xref: PTHR45615:SF24
organism: Danio rerio

uniprot O75116 507
type: UnificationXref
id: O75116
db: uniprot

uniprot F6XQ37 770
type: UnificationXref
id: F6XQ37
db: uniprot

PTHR46256:SF1
type: RelationshipXref
id: PTHR46256:SF1
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF434
type: RelationshipXref
id: PTHR11937:SF434
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot Q05933 142
organism: Saccharomyces cerevisiae

Protein CBR-RHO-1
type: ProteinReference
xref: uniprot A8XIF5 12
xref: PTHR24072:SF168
organism: Caenorhabditis briggsae

PTHR45872:SF4
type: RelationshipXref
id: PTHR45872:SF4
db: PANTHER Family
relationship type: By Homology

uniprot B5DF62 451
type: UnificationXref
id: B5DF62
db: uniprot

uniprot P53478 299
type: UnificationXref
id: P53478
db: uniprot

uniprot A0A1D5QNJ4 49
type: UnificationXref
id: A0A1D5QNJ4
db: uniprot

PTHR46256:SF4
type: RelationshipXref
id: PTHR46256:SF4
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot B3RQ31 744
organism: Trichoplax adhaerens

uniprot F6UVG3 69
type: UnificationXref
id: F6UVG3
db: uniprot

Protein enabled homolog
type: ProteinReference
xref: uniprot Q03173 445
organism: Mus musculus

Myosin heavy chain 6
type: ProteinReference
xref: PTHR45615:SF11
xref: uniprot F1N2G0 596
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot F7CU42 469
organism: Monodelphis domestica

uniprot A9TYG3 205
type: UnificationXref
id: A9TYG3
db: uniprot

uniprot O97182 133
type: UnificationXref
id: O97182
db: uniprot

uniprot P60711 308
type: UnificationXref
id: P60711
db: uniprot

PTHR11937:SF421
type: RelationshipXref
id: PTHR11937:SF421
db: PANTHER Family
relationship type: By Homology

uniprot E2QYC2 754
type: UnificationXref
id: E2QYC2
db: uniprot

PARTICIPANT STOICHIOMETRY r17 944
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r17 945
type: Stoichiometry
physical entity: Complex (GDP/Cdc42)
stoichiometric coefficient: 1.0

Myosin-4
type: ProteinReference
xref: PTHR45615:SF2
xref: uniprot Q9Y623 673
organism: Homo sapiens

PTHR11937:SF423
type: RelationshipXref
id: PTHR11937:SF423
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r17 943
type: Stoichiometry
physical entity: Complex (Cdc42/GTP)
stoichiometric coefficient: 1.0

Rho-related protein racA
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot P34147 687
organism: Dictyostelium discoideum

Rho-related protein racB
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34148 688
organism: Dictyostelium discoideum

PTHR11937:SF416
type: RelationshipXref
id: PTHR11937:SF416
db: PANTHER Family
relationship type: By Homology

Complex (Rac/GTP)
type: Complex
component stoichiometry: GTP s2 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rac s1 sa1 STOICHIOMETRY ID COMPLEX
component: Rac
component: GTP
feature: COMPLEX BINDING FEATURE s17 a26 886
feature: COMPLEX BINDING FEATURE s17 a26 884

Rho-related protein rac1B
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34145 686
organism: Dictyostelium discoideum

PTHR11588:SF9
type: RelationshipXref
id: PTHR11588:SF9
db: PANTHER Family
relationship type: By Homology

Myosin heavy chain 11
type: ProteinReference
xref: uniprot F6WFN3 612
xref: PTHR45615:SF23
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY r43 957
type: Stoichiometry
physical entity: Myosin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r43 956
type: Stoichiometry
physical entity: Myosin
stoichiometric coefficient: 1.0

uniprot Q3T035 148
type: UnificationXref
id: Q3T035
db: uniprot

uniprot Q76FS3 860
type: UnificationXref
id: Q76FS3
db: uniprot

uniprot P06780 28
type: UnificationXref
id: P06780
db: uniprot

uniprot P07437 797
type: UnificationXref
id: P07437
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6Z9H7 467
organism: Macaca mulatta

uniprot P05220 796
type: UnificationXref
id: P05220
db: uniprot

uniprot A0A3Q1MS81 578
type: UnificationXref
id: A0A3Q1MS81
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot H2QS82 784
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot E1C3P6 456
organism: Gallus gallus

uniprot Q2T9S0 831
type: UnificationXref
id: Q2T9S0
db: uniprot

Myosin light chain kinase 2, skeletal/cardiac muscle
type: ProteinReference
xref: PTHR24347:SF373
xref: uniprot P20689 408
organism: Rattus norvegicus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot E3KPL3 756
organism: Puccinia graminis

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot A0A1D5PEI5 725
organism: Gallus gallus

GTP-binding protein RHO1
type: ProteinReference
xref: uniprot O42825 24
xref: PTHR24072:SF168
organism: Candida albicans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__LIMK-RIGHT__LIMK-_r31
controller: ROCK

Tubulin beta chain
type: ProteinReference
xref: uniprot F6SYL0 767
xref: PTHR11588:SF89
organism: Ciona intestinalis

uniprot P63267 317
type: UnificationXref
id: P63267
db: uniprot

uniprot A9TLC7 675
type: UnificationXref
id: A9TLC7
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__Op18_stathmin-RIGHT__Op18_stathmin-_r40
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 959
participant stoichiometry: PARTICIPANT STOICHIOMETRY r40 958
left: Op18/stathmin
interaction type: STATE_TRANSITION
right: Op18/stathmin

uniprot C3ZTX6 234
type: UnificationXref
id: C3ZTX6
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Axonal plasticity
controller: Complex (Actin/Actin)

ncbitaxon 35128 749
type: UnificationXref
id: 35128
db: ncbitaxon

uniprot B2GV73 92
type: UnificationXref
id: B2GV73
db: uniprot

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot Q8NEV4 663
type: UnificationXref
id: Q8NEV4
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF1
xref: uniprot Q9JM76 164
organism: Mus musculus

uniprot Q9VTU3 531
type: UnificationXref
id: Q9VTU3
db: uniprot

uniprot F7EQH3 110
type: UnificationXref
id: F7EQH3
db: uniprot

Putative actin-9
type: ProteinReference
xref: uniprot P93738 335
xref: PTHR11937:SF483
organism: Arabidopsis thaliana

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 203

Actin s51 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 1.0

uniprot Q9D6F9 871
type: UnificationXref
id: Q9D6F9
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63259 314
organism: Rattus norvegicus

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63258 313
organism: Bos taurus

Actin-87E
type: ProteinReference
xref: uniprot P10981 288
xref: PTHR11937:SF397
organism: Drosophila melanogaster

uniprot O18840 278
type: UnificationXref
id: O18840
db: uniprot

uniprot F1PE53 501
type: UnificationXref
id: F1PE53
db: uniprot

LIMK
type: Protein
entity reference: LIMK
feature: T508 LIMK s7 a7 rs1
comment: SPECIES_TYPE=PROTEIN

Actin-2
type: ProteinReference
xref: uniprot P10984 289
xref: PTHR11937:SF470
organism: Caenorhabditis elegans

Actin-3
type: ProteinReference
xref: uniprot P0DM42 287
xref: PTHR11937:SF387
organism: Caenorhabditis elegans

Myosin-9
type: ProteinReference
xref: PTHR45615:SF16
xref: uniprot Q8VDD5 664
organism: Mus musculus

uniprot P68133 325
type: UnificationXref
id: P68133
db: uniprot

uniprot O00401 721
type: UnificationXref
id: O00401
db: uniprot

Cell division control protein 42 homolog isoform 2
type: ProteinReference
xref: PTHR24072:SF337
xref: uniprot F6RBZ7 419
organism: Macaca mulatta

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P63267 317
organism: Homo sapiens

PTHR48015:SF30
type: RelationshipXref
id: PTHR48015:SF30
db: PANTHER Family
relationship type: By Homology

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63261 316
organism: Homo sapiens

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot P63260 315
organism: Mus musculus

uniprot F7F4W9 269
type: UnificationXref
id: F7F4W9
db: uniprot

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P63268 318
organism: Mus musculus

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: uniprot P63269 319
xref: PTHR11937:SF201
organism: Rattus norvegicus

uniprot Q58CQ2 150
type: UnificationXref
id: Q58CQ2
db: uniprot

uniprot W4XVG9 879
type: UnificationXref
id: W4XVG9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BC64 708
organism: Bos taurus

Rho-related GTP-binding protein RhoU
type: ProteinReference
xref: uniprot A5D7J5 415
organism: Bos taurus

Rho s28 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

Rho
type: Protein
entity reference: Rho
feature: ACTIVE 48
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 899
comment: SPECIES_TYPE=PROTEIN

uniprot E2RMT4 98
type: UnificationXref
id: E2RMT4
db: uniprot

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P63270 320
organism: Gallus gallus

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C4M8K6 679
organism: Entamoeba histolytica

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot F1PT97 102
organism: Canis lupus familiaris

uniprot C3XYC3 218
type: UnificationXref
id: C3XYC3
db: uniprot

uniprot F1R6C7 606
type: UnificationXref
id: F1R6C7
db: uniprot

uniprot P53474 298
type: UnificationXref
id: P53474
db: uniprot

Actin-related protein 2/3 complex subunit 1
type: ProteinReference
xref: uniprot P38328 135
xref: PTHR10709:SF2
organism: Saccharomyces cerevisiae

Myosin-10
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot Q9JLT0 670
organism: Rattus norvegicus

Stathmin 4
type: ProteinReference
xref: uniprot A0A3Q1MX15 384
organism: Bos taurus

uniprot A2BGX6 580
type: UnificationXref
id: A2BGX6
db: uniprot

uniprot P02572 280
type: UnificationXref
id: P02572
db: uniprot

uniprot Q6RUV5 702
type: UnificationXref
id: Q6RUV5
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F7G800 471
organism: Monodelphis domestica

uniprot Q7PWN2 156
type: UnificationXref
id: Q7PWN2
db: uniprot

PARTICIPANT STOICHIOMETRY r38 924
type: Stoichiometry
physical entity: tubulin
stoichiometric coefficient: 1.0

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A2EM81 731
organism: Trichomonas vaginalis

uniprot Q61210 496
type: UnificationXref
id: Q61210
db: uniprot

PARTICIPANT STOICHIOMETRY r38 925
type: Stoichiometry
physical entity: Complex (tubulin/tubulin)
stoichiometric coefficient: 1.0

uniprot Q21193 554
type: UnificationXref
id: Q21193
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF357
xref: uniprot Q18817 827
organism: Caenorhabditis elegans

uniprot P63042 397
type: UnificationXref
id: P63042
db: uniprot

uniprot P60709 306
type: UnificationXref
id: P60709
db: uniprot

uniprot F6Y1M7 613
type: UnificationXref
id: F6Y1M7
db: uniprot

GTP-binding protein rhoA
type: ProteinReference
xref: uniprot Q9C3Y4 42
xref: PTHR24072:SF168
organism: Emericella nidulans

uniprot P35465 478
type: UnificationXref
id: P35465
db: uniprot

Rho-associated protein kinase 2
type: ProteinReference
xref: uniprot P70336 509
organism: Mus musculus

Actin, beta like 2
type: ProteinReference
xref: uniprot H2QE24 275
xref: PTHR11937:SF278
organism: Pan troglodytes

Rho-associated protein kinase 1
type: ProteinReference
xref: uniprot P70335 508
xref: PTHR22988:SF33
organism: Mus musculus

uniprot P62963 552
type: UnificationXref
id: P62963
db: uniprot

Actin-5C
type: ProteinReference
xref: uniprot P10987 291
xref: PTHR11937:SF387
organism: Drosophila melanogaster

Actin-4
type: ProteinReference
xref: PTHR11937:SF471
xref: uniprot P10986 290
organism: Caenorhabditis elegans

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P10989 292
organism: Schizosaccharomyces pombe

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V4Y9 78
organism: Macaca mulatta

Serine/threonine-protein kinase PAK 5
type: ProteinReference
xref: uniprot Q8C015 490
organism: Mus musculus

uniprot F6ZHU6 615
type: UnificationXref
id: F6ZHU6
db: uniprot

uniprot Q3ZCM7 835
type: UnificationXref
id: Q3ZCM7
db: uniprot

uniprot P10874 804
type: UnificationXref
id: P10874
db: uniprot

uniprot A8BV70 192
type: UnificationXref
id: A8BV70
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6RUV5 702
organism: Rattus norvegicus

uniprot Q9DAD6 563
type: UnificationXref
id: Q9DAD6
db: uniprot

Cofilin-1
type: ProteinReference
xref: uniprot P23528 59
organism: Homo sapiens

RHOJ protein
type: ProteinReference
xref: PTHR24072:SF17
xref: uniprot A4FV20 6
organism: Bos taurus

uniprot A0A1D5QYU3 726
type: UnificationXref
id: A0A1D5QYU3
db: uniprot

uniprot A6QLN6 581
type: UnificationXref
id: A6QLN6
db: uniprot

uniprot Q43594 837
type: UnificationXref
id: Q43594
db: uniprot

uniprot A0A2I3SQU2 575
type: UnificationXref
id: A0A2I3SQU2
db: uniprot

Profilin
type: ProteinReference
xref: uniprot C3YHE9 532
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A0A2A6CRA8 178
organism: Pristionchus pacificus

Uncharacterized protein
type: ProteinReference
xref: PTHR11588:SF293
xref: uniprot W4XVG8 878
organism: Strongylocentrotus purpuratus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot W4XVG9 879
organism: Strongylocentrotus purpuratus

uniprot W4ZD41 382
type: UnificationXref
id: W4ZD41
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GYE9 418
xref: PTHR24072:SF192
organism: Daphnia pulex

Profilin
type: ProteinReference
xref: uniprot C4MB21 533
organism: Entamoeba histolytica

uniprot Q1JP79 145
type: UnificationXref
id: Q1JP79
db: uniprot

uniprot Q9VX82 169
type: UnificationXref
id: Q9VX82
db: uniprot

Non-muscle actin 6.2
type: ProteinReference
xref: uniprot B3S5E4 214
xref: PTHR11937:SF387
organism: Trichoplax adhaerens

Myosin, heavy chain 9, non-muscle
type: ProteinReference
xref: uniprot F6YTJ1 614
organism: Xenopus tropicalis

ncbitaxon 214684 348
type: UnificationXref
id: 214684
db: ncbitaxon

uniprot P21566 58
type: UnificationXref
id: P21566
db: uniprot

uniprot P26200 547
type: UnificationXref
id: P26200
db: uniprot

uniprot A0A3Q1LVZ9 577
type: UnificationXref
id: A0A3Q1LVZ9
db: uniprot

uniprot P84185 333
type: UnificationXref
id: P84185
db: uniprot

uniprot P60953 426
type: UnificationXref
id: P60953
db: uniprot

Rac family small GTPase 1b
type: ProteinReference
xref: uniprot Q29RC5 696
xref: PTHR24072:SF105
organism: Danio rerio

uniprot C3Y3Q1 751
type: UnificationXref
id: C3Y3Q1
db: uniprot

Beta-actin-like protein 2
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot Q8BFZ3 369
organism: Mus musculus

Protein CBR-RGA-1
type: ProteinReference
xref: uniprot A8WTA3 518
organism: Caenorhabditis briggsae

Ras-like GTP-binding protein rhoA
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot Q22038 37
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZTX6 234
xref: PTHR11937:SF446
organism: Branchiostoma floridae

Myosin-9
type: ProteinReference
xref: uniprot Q62812 658
xref: PTHR45615:SF16
organism: Rattus norvegicus

Actin-57B
type: ProteinReference
xref: PTHR11937:SF397
xref: uniprot P53501 303
organism: Drosophila melanogaster

Myosin-IIIa
type: ProteinReference
xref: uniprot Q8NEV4 663
organism: Homo sapiens

T508 LIMK s7 a7 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T508
feature location: T508 LIMK s7 a7 rs1 T508
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T508
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot F7CGM4 774
organism: Monodelphis domestica

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF306
xref: uniprot P32256 810
organism: Dictyostelium discoideum

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 9

uniprot E1BTH9 717
type: UnificationXref
id: E1BTH9
db: uniprot

uniprot C4M5T0 677
type: UnificationXref
id: C4M5T0
db: uniprot

Stathmin
type: ProteinReference
evidence: Evidence 386
xref: uniprot F6WZM7 387
xref: PTHR10104:SF5
organism: Macaca mulatta

uniprot P02565 635
type: UnificationXref
id: P02565
db: uniprot

uniprot P25843 545
type: UnificationXref
id: P25843
db: uniprot

uniprot F7G800 471
type: UnificationXref
id: F7G800
db: uniprot

uniprot G2HGK8 781
type: UnificationXref
id: G2HGK8
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q3SYX9 147
xref: PTHR12644:SF1
organism: Bos taurus

uniprot A8BEI6 737
type: UnificationXref
id: A8BEI6
db: uniprot

uniprot F6TUR3 256
type: UnificationXref
id: F6TUR3
db: uniprot

uniprot Q8BTW9 489
type: UnificationXref
id: Q8BTW9
db: uniprot

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot Q62829 486
organism: Rattus norvegicus

MODULATION
type: Control
xref: MODULATION
controlled: Axonal plasticity
controller: Complex (tubulin/tubulin)

uniprot P63001 693
type: UnificationXref
id: P63001
db: uniprot

ROCK
type: ProteinReference
xref: P00519
standard name: Rho-associated coiled-coil-containing protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Rho-associated coiled-coil-containing protein kinase Synonym: Synonym not specified Accession: P00519
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.ROCK
member entity reference: Rho-associated protein kinase
member entity reference: Rho-associated protein kinase 1
member entity reference: Rho-associated protein kinase let-502
member entity reference: Rho associated coiled-coil containing protein kinase 2
member entity reference: Rho-associated protein kinase 2
member entity reference: AGAP000406-PA
member entity reference: Uncharacterized protein
member entity reference: Rho associated coiled-coil containing protein kinase 1

GTP s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot Q10316 143
type: UnificationXref
id: Q10316
db: uniprot

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 211

uniprot Q63644 514
type: UnificationXref
id: Q63644
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

Myosin-11
type: ProteinReference
xref: uniprot O08638 632
xref: PTHR45615:SF23
organism: Mus musculus

uniprot O75914 475
type: UnificationXref
id: O75914
db: uniprot

uniprot A0A2I3S3U5 574
type: UnificationXref
id: A0A2I3S3U5
db: uniprot

uniprot Q65XH8 352
type: UnificationXref
id: Q65XH8
db: uniprot

uniprot F6QWB7 251
type: UnificationXref
id: F6QWB7
db: uniprot

LIMK
type: ProteinReference
xref: P00524
standard name: LIM domain kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: LIM domain kinase 1 Synonym: LIM kinase Accession: P00524
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.LIMK
member entity reference: LIM domain kinase 1
member entity reference: Uncharacterized protein

uniprot F7CIV4 264
type: UnificationXref
id: F7CIV4
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF22
xref: uniprot F6T2E7 463
organism: Xenopus tropicalis

PTHR47633:SF1
type: RelationshipXref
id: PTHR47633:SF1
db: PANTHER Family
relationship type: By Homology

uniprot F7G124 621
type: UnificationXref
id: F7G124
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Actin_Actin_-RIGHT__Actin-_r29
controller: Cofilin

uniprot Q94124 705
type: UnificationXref
id: Q94124
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7GWI2 472
xref: PTHR48015:SF22
organism: Macaca mulatta

uniprot F7CGM4 774
type: UnificationXref
id: F7CGM4
db: uniprot

uniprot Q4KLF8 149
type: UnificationXref
id: Q4KLF8
db: uniprot

uniprot H3FHK9 788
type: UnificationXref
id: H3FHK9
db: uniprot

Actin, cytoskeletal 3B
type: ProteinReference
xref: uniprot P18499 293
xref: PTHR11937:SF387
organism: Strongylocentrotus purpuratus

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 21

Tubulin beta-2B chain
type: ProteinReference
xref: PTHR11588:SF330
xref: uniprot Q9BVA1 869
organism: Homo sapiens

Stathmin
type: ProteinReference
evidence: Evidence 394
xref: PTHR10104:SF5
xref: uniprot P16949 392
organism: Homo sapiens

uniprot Q9U1E8 376
type: UnificationXref
id: Q9U1E8
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MY55 461
organism: Bos taurus

uniprot Q13153 480
type: UnificationXref
id: Q13153
db: uniprot

Protein phosphatase Slingshot homolog 3
type: ProteinReference
xref: uniprot Q8K330 73
organism: Mus musculus

uniprot P83967 332
type: UnificationXref
id: P83967
db: uniprot

uniprot C3YKS6 228
type: UnificationXref
id: C3YKS6
db: uniprot

uniprot P58798 137
type: UnificationXref
id: P58798
db: uniprot

uniprot Q9CVB6 163
type: UnificationXref
id: Q9CVB6
db: uniprot

uniprot Q9VXE3 516
type: UnificationXref
id: Q9VXE3
db: uniprot

uniprot Q75HX0 364
type: UnificationXref
id: Q75HX0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SCP4 254
xref: PTHR11937:SF387
organism: Ciona intestinalis

Stathmin
type: ProteinReference
evidence: Evidence 386
xref: PTHR10104:SF5
xref: uniprot F6V9E8 385
organism: Monodelphis domestica

PTHR48015:SF22
type: RelationshipXref
id: PTHR48015:SF22
db: PANTHER Family
relationship type: By Homology

uniprot H2QC98 627
type: UnificationXref
id: H2QC98
db: uniprot

PTHR48015:SF20
type: RelationshipXref
id: PTHR48015:SF20
db: PANTHER Family
relationship type: By Homology

PTHR24072:SF281
type: RelationshipXref
id: PTHR24072:SF281
db: PANTHER Family
relationship type: By Homology

uniprot F6SCX2 610
type: UnificationXref
id: F6SCX2
db: uniprot

uniprot W4XTP5 380
type: UnificationXref
id: W4XTP5
db: uniprot

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa4 901
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Myosin heavy chain 7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot A0A3Q1MS81 578
organism: Bos taurus

uniprot Q6GL82 152
type: UnificationXref
id: Q6GL82
db: uniprot

ncbitaxon 184922 193
type: UnificationXref
id: 184922
db: ncbitaxon

uniprot Q10DV7 338
type: UnificationXref
id: Q10DV7
db: uniprot

Myosin heavy chain 14
type: ProteinReference
xref: uniprot F1MM57 592
organism: Bos taurus

Myosin
type: Protein
entity reference: Myosin
feature: Myosin s40 a60 rs1
comment: SPECIES_TYPE=PROTEIN

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot P59999 139
xref: PTHR22629:SF0
organism: Mus musculus

uniprot A7SCN8 189
type: UnificationXref
id: A7SCN8
db: uniprot

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot P59998 138
xref: PTHR22629:SF0
organism: Homo sapiens

uniprot H2Q943 274
type: UnificationXref
id: H2Q943
db: uniprot

Tubulin beta-2B chain
type: ProteinReference
xref: PTHR11588:SF330
xref: uniprot Q9CWF2 870
organism: Mus musculus

Rho guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot Q61210 496
xref: PTHR45872:SF4
organism: Mus musculus

uniprot A7ETS6 186
type: UnificationXref
id: A7ETS6
db: uniprot

Myosin heavy chain 7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot B6RK61 585
organism: Rattus norvegicus

Actin-3
type: ProteinReference
xref: PTHR11937:SF411
xref: uniprot Q10AZ4 337
organism: Oryza sativa

PTHR24072:SF287
type: RelationshipXref
id: PTHR24072:SF287
db: PANTHER Family
relationship type: By Homology

uniprot Q5KP06 347
type: UnificationXref
id: Q5KP06
db: uniprot

ncbitaxon 7165 154
type: UnificationXref
id: 7165
db: ncbitaxon

GDP s36 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Rho GEFs
type: ProteinReference
xref: P00518
standard name: Rho guanine nucleotide exchange factors
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Rho GEFs
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Rho guanine nucleotide exchange factors Synonym: ARHGEF Accession: P00518
member entity reference: Rho guanine nucleotide exchange factor 1
member entity reference: ARHGEF1 isoform 4

uniprot P32256 810
type: UnificationXref
id: P32256
db: uniprot

uniprot P78929 62
type: UnificationXref
id: P78929
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR46256:SF4
xref: uniprot F6VF32 611
organism: Macaca mulatta

uniprot Q9C3Y4 42
type: UnificationXref
id: Q9C3Y4
db: uniprot

uniprot C3ZIB9 417
type: UnificationXref
id: C3ZIB9
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot B8C8B4 748
organism: Thalassiosira pseudonana

uniprot P70336 509
type: UnificationXref
id: P70336
db: uniprot

uniprot F7E840 777
type: UnificationXref
id: F7E840
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 125

Rac
type: Protein
entity reference: Rac
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa8 915
comment: SPECIES_TYPE=PROTEIN

uniprot P45592 61
type: UnificationXref
id: P45592
db: uniprot

uniprot H2KNE6 271
type: UnificationXref
id: H2KNE6
db: uniprot

Actin beta
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F6UDX9 259
organism: Ornithorhynchus anatinus

RhoA protein
type: ProteinReference
xref: uniprot A7EEX6 8
xref: PTHR24072:SF168
organism: Sclerotinia sclerotiorum

uniprot F4NUL6 764
type: UnificationXref
id: F4NUL6
db: uniprot

uniprot E2RJA0 460
type: UnificationXref
id: E2RJA0
db: uniprot

uniprot F6X9N6 107
type: UnificationXref
id: F6X9N6
db: uniprot

uniprot Q9R0Q6 165
type: UnificationXref
id: Q9R0Q6
db: uniprot

uniprot A2AQP0 579
type: UnificationXref
id: A2AQP0
db: uniprot

Stathmin
type: ProteinReference
evidence: Evidence 386
xref: PTHR10104:SF5
xref: uniprot P13668 391
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Rho_GTP_-RIGHT__Complex__GDP_Rho_-_Pi-_r15
controller: Rho GAPs

Cdc42
type: Protein
entity reference: Cdc42
feature: ACTIVE 48
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa5 907
comment: SPECIES_TYPE=PROTEIN

Evidence 386
type: Evidence
evidence code: ISS
comment: Website http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3925

uniprot H2QVA9 720
type: UnificationXref
id: H2QVA9
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot F7FN72 111
organism: Ornithorhynchus anatinus

uniprot Q6PE34 853
type: UnificationXref
id: Q6PE34
db: uniprot

uniprot P60010 304
type: UnificationXref
id: P60010
db: uniprot

Trichomonas vaginalis
type: BioSource
xref: ncbitaxon 5722 181

PTHR10104:SF5
type: RelationshipXref
id: PTHR10104:SF5
db: PANTHER Family
relationship type: By Homology

uniprot A2FA04 180
type: UnificationXref
id: A2FA04
db: uniprot

uniprot Q62829 486
type: UnificationXref
id: Q62829
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 158

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: uniprot Q9VIM5 167
xref: PTHR12058:SF0
organism: Drosophila melanogaster

uniprot P02557 793
type: UnificationXref
id: P02557
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot A0A1D5Q7K7 175
organism: Macaca mulatta

Rho-associated protein kinase
type: ProteinReference
xref: uniprot A0A0R4IHT4 499
organism: Danio rerio

uniprot F7B0P2 772
type: UnificationXref
id: F7B0P2
db: uniprot

eco ECO:0000501 393
type: UnificationXref
id: ECO:0000501
db: eco

Tubulin beta chain
type: ProteinReference
xref: uniprot Q5BL39 845
xref: PTHR11588:SF295
organism: Xenopus tropicalis

uniprot A7SEA7 190
type: UnificationXref
id: A7SEA7
db: uniprot

uniprot F6T0E0 521
type: UnificationXref
id: F6T0E0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7D0R0 53
organism: Monodelphis domestica

uniprot Q8ILW9 372
type: UnificationXref
id: Q8ILW9
db: uniprot

uniprot C3YHE9 532
type: UnificationXref
id: C3YHE9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6R0F5 608
xref: PTHR45615:SF23
organism: Macaca mulatta

uniprot Q076A8 652
type: UnificationXref
id: Q076A8
db: uniprot

PARTICIPANT STOICHIOMETRY r40 959
type: Stoichiometry
physical entity: Op18/stathmin
stoichiometric coefficient: 1.0

uniprot P60706 305
type: UnificationXref
id: P60706
db: uniprot

Tubulin beta-3 chain
type: ProteinReference
xref: uniprot Q9ERD7 872
xref: PTHR11588:SF43
organism: Mus musculus

uniprot A0A2I3TDQ7 51
type: UnificationXref
id: A0A2I3TDQ7
db: uniprot

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 174

PARTICIPANT STOICHIOMETRY r40 958
type: Stoichiometry
physical entity: Op18/stathmin
stoichiometric coefficient: 1.0

Cofilin
type: ProteinReference
xref: P00508
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cofilin Synonym: Actin depolymerizing factor,CFL Accession: P00508
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Cofilin
member entity reference: Cofilin-2
member entity reference: Cofilin
member entity reference: Cofilin 2
member entity reference: Cofilin-1
member entity reference: Uncharacterized protein
member entity reference: CFL2 isoform 1
member entity reference: CFL1 isoform 2

PTHR11588:SF329
type: RelationshipXref
id: PTHR11588:SF329
db: PANTHER Family
relationship type: By Homology

uniprot O80856 124
type: UnificationXref
id: O80856
db: uniprot

PTHR11588:SF325
type: RelationshipXref
id: PTHR11588:SF325
db: PANTHER Family
relationship type: By Homology

Non-muscle actin 6.2
type: ProteinReference
xref: uniprot B3RX77 213
xref: PTHR11937:SF387
organism: Trichoplax adhaerens

ncbitaxon 6945 216
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot C3Z4K3 230
type: UnificationXref
id: C3Z4K3
db: uniprot

ncbitaxon 6239 38
type: UnificationXref
id: 6239
db: ncbitaxon

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: uniprot P50551 441
xref: PTHR11202:SF12
organism: Canis lupus familiaris

PTHR11588:SF321
type: RelationshipXref
id: PTHR11588:SF321
db: PANTHER Family
relationship type: By Homology

uniprot Q5U1Y2 697
type: UnificationXref
id: Q5U1Y2
db: uniprot

PTHR11937:SF483
type: RelationshipXref
id: PTHR11937:SF483
db: PANTHER Family
relationship type: By Homology

Actin (Fragment)
type: ProteinReference
xref: uniprot A2HNG1 183
xref: PTHR11937:SF387
organism: Trichomonas vaginalis

PTHR24072:SF0
type: RelationshipXref
id: PTHR24072:SF0
db: PANTHER Family
relationship type: By Homology

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: uniprot P50552 442
xref: PTHR11202:SF12
organism: Homo sapiens

Rho GTPase-activating protein 8
type: ProteinReference
xref: uniprot P85298 525
organism: Homo sapiens

uniprot Q9HE04 45
type: UnificationXref
id: Q9HE04
db: uniprot

ncbitaxon 7668 294
type: UnificationXref
id: 7668
db: ncbitaxon

GTP-binding protein rho1
type: ProteinReference
xref: uniprot Q09914 34
xref: PTHR24072:SF168
organism: Schizosaccharomyces pombe

STATE_TRANSITION_LEFT__mDia-RIGHT__mDia-_r45
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 952
participant stoichiometry: PARTICIPANT STOICHIOMETRY r45 953
left: mDia
interaction type: STATE_TRANSITION
right: mDia

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot O18840 278
xref: PTHR11937:SF192
organism: Canis lupus familiaris

uniprot P07737 544
type: UnificationXref
id: P07737
db: uniprot

uniprot Q9BE39 668
type: UnificationXref
id: Q9BE39
db: uniprot

uniprot P53669 714
type: UnificationXref
id: P53669
db: uniprot

uniprot A9V489 208
type: UnificationXref
id: A9V489
db: uniprot

PTHR11588:SF314
type: RelationshipXref
id: PTHR11588:SF314
db: PANTHER Family
relationship type: By Homology

uniprot F6ZYS7 388
type: UnificationXref
id: F6ZYS7
db: uniprot

Rho s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rho
stoichiometric coefficient: 1.0

PTHR11588:SF310
type: RelationshipXref
id: PTHR11588:SF310
db: PANTHER Family
relationship type: By Homology

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7RU31 187
organism: Nematostella vectensis

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QNJ4 49
organism: Macaca mulatta

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q4QBZ6 840
organism: Leishmania major

uniprot P34147 687
type: UnificationXref
id: P34147
db: uniprot

uniprot F6SDC9 255
type: UnificationXref
id: F6SDC9
db: uniprot

PTHR45615:SF6
type: RelationshipXref
id: PTHR45615:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF1
type: RelationshipXref
id: PTHR45615:SF1
db: PANTHER Family
relationship type: By Homology

Tubulin beta-2 chain
type: ProteinReference
xref: PTHR11588:SF314
xref: uniprot P61857 817
organism: Drosophila melanogaster

Rho GAPs
type: ProteinReference
xref: P00520
standard name: Rho-GTPase-activating proteins
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Rho GAPs
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Rho-GTPase-activating proteins Synonym: ARHGAPs Accession: P00520
member entity reference: Cdc42 GTPase-activating protein
member entity reference: Rho GTPase activating protein 1
member entity reference: Uncharacterized protein
member entity reference: Rho GTPase-activating protein 1
member entity reference: Protein CBR-RGA-1
member entity reference: Proline-rich protein 5
member entity reference: Rho GTPase-activating protein 68F
member entity reference: ARHGAP1 isoform 3
member entity reference: Rho GTPase Activating protein
member entity reference: Rho GTPase-activating protein 8

PTHR45615:SF2
type: RelationshipXref
id: PTHR45615:SF2
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF3
type: RelationshipXref
id: PTHR45615:SF3
db: PANTHER Family
relationship type: By Homology

uniprot F1PJ01 600
type: UnificationXref
id: F1PJ01
db: uniprot

uniprot E9GER1 758
type: UnificationXref
id: E9GER1
db: uniprot

Proline-rich protein 5
type: ProteinReference
xref: uniprot Q5FVG6 528
organism: Rattus norvegicus

PTHR11588:SF306
type: RelationshipXref
id: PTHR11588:SF306
db: PANTHER Family
relationship type: By Homology

Actin-5C
type: ProteinReference
xref: uniprot P84185 333
xref: PTHR11937:SF387
organism: Anopheles gambiae

PTHR11937:SF468
type: RelationshipXref
id: PTHR11937:SF468
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF469
type: RelationshipXref
id: PTHR11937:SF469
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot F7EQH3 110
organism: Monodelphis domestica

PTHR11937:SF464
type: RelationshipXref
id: PTHR11937:SF464
db: PANTHER Family
relationship type: By Homology

uniprot F1NM49 597
type: UnificationXref
id: F1NM49
db: uniprot

uniprot E2RCG1 718
type: UnificationXref
id: E2RCG1
db: uniprot

uniprot Q38904 557
type: UnificationXref
id: Q38904
db: uniprot

uniprot O96625 131
type: UnificationXref
id: O96625
db: uniprot

uniprot P13668 391
type: UnificationXref
id: P13668
db: uniprot

uniprot F7DDX8 503
type: UnificationXref
id: F7DDX8
db: uniprot

Myosin-11
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot P10587 636
organism: Gallus gallus

Predicted protein
type: ProteinReference
xref: PTHR11937:SF473
xref: uniprot A7SEB1 191
organism: Nematostella vectensis

PTHR11588:SF301
type: RelationshipXref
id: PTHR11588:SF301
db: PANTHER Family
relationship type: By Homology

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 57

Rho associated coiled-coil containing protein kinase 2
type: ProteinReference
xref: uniprot F1PE53 501
organism: Canis lupus familiaris

Protein phosphatase Slingshot homolog 3
type: ProteinReference
xref: uniprot Q5XIS1 71
organism: Rattus norvegicus

Myosin light chain kinase 2, skeletal/cardiac muscle
type: ProteinReference
xref: PTHR24347:SF373
xref: uniprot Q8VCR8 413
organism: Mus musculus

uniprot F7GP56 623
type: UnificationXref
id: F7GP56
db: uniprot

Cytoplasmatic actin
type: ProteinReference
xref: uniprot E9FZ00 240
xref: PTHR11937:SF387
organism: Daphnia pulex

Rho guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot Q9Z1I6 498
xref: PTHR45872:SF4
organism: Rattus norvegicus

uniprot P40793 423
type: UnificationXref
id: P40793
db: uniprot

Probable tubulin beta chain CG32396
type: ProteinReference
xref: PTHR11588:SF293
xref: uniprot Q9VRX3 874
organism: Drosophila melanogaster

PTHR11937:SF477
type: RelationshipXref
id: PTHR11937:SF477
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: uniprot A9RQS1 741
xref: PTHR11588:SF365
organism: Physcomitrella patens

uniprot P62737 311
type: UnificationXref
id: P62737
db: uniprot

uniprot Q3MHR7 146
type: UnificationXref
id: Q3MHR7
db: uniprot

PTHR11937:SF473
type: RelationshipXref
id: PTHR11937:SF473
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF474
type: RelationshipXref
id: PTHR11937:SF474
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YP58 229
xref: PTHR11937:SF468
organism: Branchiostoma floridae

PTHR11937:SF471
type: RelationshipXref
id: PTHR11937:SF471
db: PANTHER Family
relationship type: By Homology

Predicted protein
type: ProteinReference
xref: uniprot A7SEA7 190
xref: PTHR11937:SF387
organism: Nematostella vectensis

uniprot F6U702 439
type: UnificationXref
id: F6U702
db: uniprot

PTHR11937:SF470
type: RelationshipXref
id: PTHR11937:SF470
db: PANTHER Family
relationship type: By Homology

uniprot Q5M8T9 349
type: UnificationXref
id: Q5M8T9
db: uniprot

Myosin-4
type: ProteinReference
xref: uniprot Q29RW1 654
xref: PTHR45615:SF2
organism: Rattus norvegicus

ARHGAP1 isoform 3
type: ProteinReference
xref: PTHR45808:SF6
xref: uniprot H2Q3I0 524
organism: Pan troglodytes

uniprot P0DM41 286
type: UnificationXref
id: P0DM41
db: uniprot

PTHR11588:SF361
type: RelationshipXref
id: PTHR11588:SF361
db: PANTHER Family
relationship type: By Homology

uniprot Q7ZVF9 367
type: UnificationXref
id: Q7ZVF9
db: uniprot

uniprot P02563 633
type: UnificationXref
id: P02563
db: uniprot

S16 Op18 stathmin s38 a58 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S16
feature location: S16 Op18 stathmin s38 a58 rs1 S16
comment: MODIFICATION_RESIDUE_NAME=S16
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.677945044588987

uniprot Q9FUD1 566
type: UnificationXref
id: Q9FUD1
db: uniprot

PTHR11588:SF365
type: RelationshipXref
id: PTHR11588:SF365
db: PANTHER Family
relationship type: By Homology

uniprot K7AX49 506
type: UnificationXref
id: K7AX49
db: uniprot

uniprot Q553U6 343
type: UnificationXref
id: Q553U6
db: uniprot

uniprot P11799 407
type: UnificationXref
id: P11799
db: uniprot

Tubulin beta-5 chain
type: ProteinReference
xref: PTHR11588:SF61
xref: uniprot P69897 821
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF1
xref: uniprot F6SCX2 610
organism: Monodelphis domestica

Tubulin beta chain
type: ProteinReference
xref: uniprot P69895 820
xref: PTHR11588:SF61
organism: Macaca mulatta

uniprot A7RU31 187
type: UnificationXref
id: A7RU31
db: uniprot

uniprot O96626 132
type: UnificationXref
id: O96626
db: uniprot

uniprot J9NVP2 390
type: UnificationXref
id: J9NVP2
db: uniprot

uniprot O14241 119
type: UnificationXref
id: O14241
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot O15511 123
xref: PTHR12644:SF1
organism: Homo sapiens

uniprot W4Y969 381
type: UnificationXref
id: W4Y969
db: uniprot

Cofilin
type: ProteinReference
xref: uniprot P78929 62
organism: Schizosaccharomyces pombe

uniprot A7EEX6 8
type: UnificationXref
id: A7EEX6
db: uniprot

uniprot Q9VXE5 494
type: UnificationXref
id: Q9VXE5
db: uniprot

uniprot A9TZ58 207
type: UnificationXref
id: A9TZ58
db: uniprot

Tubulin beta-5 chain
type: ProteinReference
xref: uniprot P99024 823
xref: PTHR11588:SF61
organism: Mus musculus

Cdc42 protein, putative
type: ProteinReference
xref: uniprot B7PHY7 416
xref: PTHR24072:SF192
organism: Ixodes scapularis

PTHR11588:SF357
type: RelationshipXref
id: PTHR11588:SF357
db: PANTHER Family
relationship type: By Homology

uniprot E3KPL3 756
type: UnificationXref
id: E3KPL3
db: uniprot

ROCK
type: Protein
entity reference: ROCK
feature: ACTIVE 48
comment: SPECIES_TYPE=PROTEIN

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 100

uniprot Q6TYR8 857
type: UnificationXref
id: Q6TYR8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZMR2 233
organism: Branchiostoma floridae

Myosin heavy chain, non-muscle
type: ProteinReference
xref: uniprot Q99323 667
xref: PTHR45615:SF40
organism: Drosophila melanogaster

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: uniprot A0A0G2K9C0 437
xref: PTHR11202:SF12
organism: Rattus norvegicus

uniprot A7SHY4 735
type: UnificationXref
id: A7SHY4
db: uniprot

uniprot O17921 792
type: UnificationXref
id: O17921
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa11 917
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9UVF3 378
type: UnificationXref
id: Q9UVF3
db: uniprot

uniprot P02564 634
type: UnificationXref
id: P02564
db: uniprot

Rac family small GTPase 3b
type: ProteinReference
xref: PTHR24072:SF301
xref: uniprot A9JRY8 674
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZIB9 417
xref: PTHR24072:SF192
organism: Branchiostoma floridae

uniprot P85970 141
type: UnificationXref
id: P85970
db: uniprot

uniprot A9TVP1 204
type: UnificationXref
id: A9TVP1
db: uniprot

PTHR11588:SF330
type: RelationshipXref
id: PTHR11588:SF330
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot F4P7H8 766
organism: Batrachochytrium dendrobatidis

PTHR11588:SF334
type: RelationshipXref
id: PTHR11588:SF334
db: PANTHER Family
relationship type: By Homology

uniprot F6WZM7 387
type: UnificationXref
id: F6WZM7
db: uniprot

PTHR11588:SF339
type: RelationshipXref
id: PTHR11588:SF339
db: PANTHER Family
relationship type: By Homology

uniprot F6RBZ7 419
type: UnificationXref
id: F6RBZ7
db: uniprot

uniprot Q9Y7J4 172
type: UnificationXref
id: Q9Y7J4
db: uniprot

Myosin-IIIb
type: ProteinReference
xref: uniprot Q8WXR4 665
organism: Homo sapiens

Profilin
type: ProteinReference
xref: uniprot Q382F9 556
organism: Trypanosoma brucei

Protein CBG02167
type: ProteinReference
xref: uniprot A8WS37 198
xref: PTHR11937:SF470
organism: Caenorhabditis briggsae

STATE_TRANSITION_LEFT__LIMK-RIGHT__LIMK-_r31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 935
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 934
left: LIMK
interaction type: STATE_TRANSITION
right: LIMK

PTHR11588:SF253
type: RelationshipXref
id: PTHR11588:SF253
db: PANTHER Family
relationship type: By Homology

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot Q3T035 148
xref: PTHR12391:SF1
organism: Bos taurus

uniprot F1R3G4 605
type: UnificationXref
id: F1R3G4
db: uniprot

uniprot Q76FS2 859
type: UnificationXref
id: Q76FS2
db: uniprot

Serine/threonine-protein kinase PAK 4
type: ProteinReference
xref: uniprot O96013 477
organism: Homo sapiens

uniprot Q7PUF2 155
type: UnificationXref
id: Q7PUF2
db: uniprot

uniprot Q7ZUQ0 157
type: UnificationXref
id: Q7ZUQ0
db: uniprot

uniprot P19073 422
type: UnificationXref
id: P19073
db: uniprot

uniprot Q6IQL9 356
type: UnificationXref
id: Q6IQL9
db: uniprot

uniprot E2R481 457
type: UnificationXref
id: E2R481
db: uniprot

Myosin-14
type: ProteinReference
xref: PTHR45615:SF31
xref: uniprot Q7Z406 661
organism: Homo sapiens

Cofilin 2
type: ProteinReference
xref: uniprot J9P2G7 55
organism: Canis lupus familiaris

uniprot J9P2G7 55
type: UnificationXref
id: J9P2G7
db: uniprot

uniprot P93738 335
type: UnificationXref
id: P93738
db: uniprot

Protein CBG02161
type: ProteinReference
xref: uniprot A8WS32 196
xref: PTHR11937:SF471
organism: Caenorhabditis briggsae

Protein CBG02162
type: ProteinReference
xref: uniprot A8WS33 197
xref: PTHR11937:SF471
organism: Caenorhabditis briggsae

uniprot Q6TYR7 856
type: UnificationXref
id: Q6TYR7
db: uniprot

Tubulin beta chain (Fragment)
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A7SHY4 735
organism: Nematostella vectensis

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZHN2 231
xref: PTHR11937:SF446
organism: Branchiostoma floridae

uniprot Q5BL39 845
type: UnificationXref
id: Q5BL39
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZHN4 232
xref: PTHR11937:SF446
organism: Branchiostoma floridae

uniprot F7H1Q7 421
type: UnificationXref
id: F7H1Q7
db: uniprot

Tubulin beta-4B chain
type: ProteinReference
xref: uniprot Q3MHM5 833
xref: PTHR11588:SF247
organism: Bos taurus

uniprot P29517 809
type: UnificationXref
id: P29517
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RFW8 253
xref: PTHR11937:SF192
organism: Monodelphis domestica

uniprot P33204 134
type: UnificationXref
id: P33204
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot E2QSF4 753
xref: PTHR11588:SF61
organism: Canis lupus familiaris

Ras-related protein rac-2
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot Q94124 705
organism: Caenorhabditis elegans

uniprot Q6GL60 700
type: UnificationXref
id: Q6GL60
db: uniprot

Myosin-3
type: ProteinReference
xref: uniprot P11055 638
xref: PTHR45615:SF6
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Actin_Actin_-RIGHT__Actin-_r29
controller: Myosin

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 379

uniprot F1PVV7 601
type: UnificationXref
id: F1PVV7
db: uniprot

PTHR11588:SF279
type: RelationshipXref
id: PTHR11588:SF279
db: PANTHER Family
relationship type: By Homology

ncbitaxon 6238 13
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot A8Y4R0 201
type: UnificationXref
id: A8Y4R0
db: uniprot

uniprot B7Q717 747
type: UnificationXref
id: B7Q717
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F6TYN8 768
xref: PTHR11588:SF55
organism: Ornithorhynchus anatinus

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: uniprot Q3ZC07 341
xref: PTHR11937:SF176
organism: Bos taurus

uniprot G3UW82 624
type: UnificationXref
id: G3UW82
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot A0A3P6PCS5 87
xref: PTHR10709:SF2
organism: Caenorhabditis elegans

uniprot O93468 26
type: UnificationXref
id: O93468
db: uniprot

PTHR11588:SF273
type: RelationshipXref
id: PTHR11588:SF273
db: PANTHER Family
relationship type: By Homology

uniprot F6PVY4 103
type: UnificationXref
id: F6PVY4
db: uniprot

uniprot P60766 424
type: UnificationXref
id: P60766
db: uniprot

uniprot Q6ZHA3 703
type: UnificationXref
id: Q6ZHA3
db: uniprot

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

uniprot Q9BUF5 868
type: UnificationXref
id: Q9BUF5
db: uniprot

uniprot P90623 334
type: UnificationXref
id: P90623
db: uniprot

uniprot P53667 712
type: UnificationXref
id: P53667
db: uniprot

Tubulin beta-1 chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q24560 828
organism: Drosophila melanogaster

uniprot F6SYL0 767
type: UnificationXref
id: F6SYL0
db: uniprot

Actin
type: Protein
entity reference: Actin
comment: SPECIES_TYPE=PROTEIN

PTHR11588:SF280
type: RelationshipXref
id: PTHR11588:SF280
db: PANTHER Family
relationship type: By Homology

uniprot P34145 686
type: UnificationXref
id: P34145
db: uniprot

ncbitaxon 6669 17
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot P53501 303
type: UnificationXref
id: P53501
db: uniprot

Protein diaphanous homolog 1
type: ProteinReference
xref: uniprot O60610 81
organism: Homo sapiens

ncbitaxon 9031 27
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot P02574 281
type: UnificationXref
id: P02574
db: uniprot

uniprot H3DZP3 787
type: UnificationXref
id: H3DZP3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot F7DIB7 265
organism: Monodelphis domestica

Tubulin beta-1 chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot P10653 803
organism: Emericella nidulans

uniprot F0ZMZ8 680
type: UnificationXref
id: F0ZMZ8
db: uniprot

ncbitaxon 10116 57
type: UnificationXref
id: 10116
db: ncbitaxon

PTHR11937:SF176
type: RelationshipXref
id: PTHR11937:SF176
db: PANTHER Family
relationship type: By Homology

PTHR11588:SF295
type: RelationshipXref
id: PTHR11588:SF295
db: PANTHER Family
relationship type: By Homology

PTHR11588:SF293
type: RelationshipXref
id: PTHR11588:SF293
db: PANTHER Family
relationship type: By Homology

uniprot Q7JJU6 861
type: UnificationXref
id: Q7JJU6
db: uniprot

PTHR11588:SF291
type: RelationshipXref
id: PTHR11588:SF291
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase pak-1
type: ProteinReference
xref: uniprot Q17850 482
organism: Caenorhabditis elegans

Tubulin beta chain
type: ProteinReference
xref: uniprot F7F082 778
xref: PTHR11588:SF61
organism: Monodelphis domestica

uniprot A0A1D5RB13 716
type: UnificationXref
id: A0A1D5RB13
db: uniprot

uniprot A0A2I3TIW8 576
type: UnificationXref
id: A0A2I3TIW8
db: uniprot

Cofilin 2
type: ProteinReference
xref: uniprot M0RC65 56
organism: Rattus norvegicus

uniprot H2Q960 473
type: UnificationXref
id: H2Q960
db: uniprot

actin, muscle
type: ProteinReference
xref: uniprot F6SDC9 255
organism: Ciona intestinalis

ncbitaxon 45351 11
type: UnificationXref
id: 45351
db: ncbitaxon

uniprot F7FPY5 112
type: UnificationXref
id: F7FPY5
db: uniprot

Protein enabled homolog
type: ProteinReference
xref: uniprot Q8N8S7 446
organism: Homo sapiens

Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q07960 526
xref: PTHR45808:SF6
organism: Homo sapiens

uniprot A8WS33 197
type: UnificationXref
id: A8WS33
db: uniprot

PTHR11937:SF168
type: RelationshipXref
id: PTHR11937:SF168
db: PANTHER Family
relationship type: By Homology

Myosin, heavy polypeptide 2, fast muscle-specific
type: ProteinReference
xref: uniprot Q6IQX1 659
xref: PTHR45615:SF44
organism: Danio rerio

uniprot Q55EU6 344
type: UnificationXref
id: Q55EU6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__mDia-RIGHT__mDia-_r45
controller: Complex (Rho/GTP)

uniprot A8XSM9 90
type: UnificationXref
id: A8XSM9
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q4KLF8 149
xref: PTHR12644:SF1
organism: Rattus norvegicus

Profilin
type: ProteinReference
xref: uniprot F7H2A5 539
organism: Macaca mulatta

uniprot E2RFV2 755
type: UnificationXref
id: E2RFV2
db: uniprot

PTHR11937:SF162
type: RelationshipXref
id: PTHR11937:SF162
db: PANTHER Family
relationship type: By Homology

uniprot F1PWZ2 602
type: UnificationXref
id: F1PWZ2
db: uniprot

Myosin-6
type: ProteinReference
xref: uniprot Q02566 648
xref: PTHR45615:SF11
organism: Mus musculus

Actin s48 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 2.0

N-WASP
type: Protein
entity reference: N-WASP
comment: SPECIES_TYPE=PROTEIN

PTHR11937:SF154
type: RelationshipXref
id: PTHR11937:SF154
db: PANTHER Family
relationship type: By Homology

ncbitaxon 10228 15
type: UnificationXref
id: 10228
db: ncbitaxon

PTHR11937:SF150
type: RelationshipXref
id: PTHR11937:SF150
db: PANTHER Family
relationship type: By Homology

PAK
type: Protein
entity reference: PAK
feature: ACTIVE 48
comment: SPECIES_TYPE=PROTEIN

uniprot P10676 637
type: UnificationXref
id: P10676
db: uniprot

PTHR11588:SF88
type: RelationshipXref
id: PTHR11588:SF88
db: PANTHER Family
relationship type: By Homology

PTHR11588:SF89
type: RelationshipXref
id: PTHR11588:SF89
db: PANTHER Family
relationship type: By Homology

Complex (GDP/Cdc42)
type: Complex
component stoichiometry: GDP s36 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Cdc42 s45 sa12 STOICHIOMETRY ID COMPLEX
component: GDP
component: Cdc42
feature: COMPLEX BINDING FEATURE s24 a35 916
feature: COMPLEX BINDING FEATURE s24 a35 918

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot Q1JP79 145
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Cofilin-RIGHT__Cofilin-_r36
controller: Slingshot

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot Q92352 160
organism: Schizosaccharomyces pombe

uniprot F1P3X1 598
type: UnificationXref
id: F1P3X1
db: uniprot

uniprot Q3ZBU7 834
type: UnificationXref
id: Q3ZBU7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24347:SF373
xref: uniprot E1BX17 402
organism: Gallus gallus

uniprot E2QWU0 97
type: UnificationXref
id: E2QWU0
db: uniprot

Tubulin beta-1 chain
type: ProteinReference
xref: PTHR11588:SF361
xref: uniprot Q43594 837
organism: Oryza sativa

uniprot Q9H169 400
type: UnificationXref
id: Q9H169
db: uniprot

uniprot B8C8B4 748
type: UnificationXref
id: B8C8B4
db: uniprot

ncbitaxon 9258 23
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot F7CB79 773
type: UnificationXref
id: F7CB79
db: uniprot

uniprot Q13509 825
type: UnificationXref
id: Q13509
db: uniprot

uniprot P10653 803
type: UnificationXref
id: P10653
db: uniprot

PTHR22629:SF0
type: RelationshipXref
id: PTHR22629:SF0
db: PANTHER Family
relationship type: By Homology

uniprot F7DCY3 776
type: UnificationXref
id: F7DCY3
db: uniprot

uniprot O15143 120
type: UnificationXref
id: O15143
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot A8XT67 91
xref: PTHR10709:SF2
organism: Caenorhabditis briggsae

Tubulin beta-8 chain
type: ProteinReference
xref: PTHR11588:SF389
xref: uniprot P29516 808
organism: Arabidopsis thaliana

Rho-associated protein kinase 2
type: ProteinReference
xref: uniprot Q28021 512
organism: Bos taurus

Tubulin beta-9 chain
type: ProteinReference
xref: PTHR11588:SF395
xref: uniprot P29517 809
organism: Arabidopsis thaliana

Tubulin beta chain
type: ProteinReference
xref: uniprot F7E840 777
xref: PTHR11588:SF55
organism: Macaca mulatta

uniprot Q8CFN2 432
type: UnificationXref
id: Q8CFN2
db: uniprot

uniprot Q56YW9 844
type: UnificationXref
id: Q56YW9
db: uniprot

uniprot E1BS97 455
type: UnificationXref
id: E1BS97
db: uniprot

uniprot A0A2I3RKA2 572
type: UnificationXref
id: A0A2I3RKA2
db: uniprot

uniprot Q9NQU5 492
type: UnificationXref
id: Q9NQU5
db: uniprot

uniprot P26199 546
type: UnificationXref
id: P26199
db: uniprot

Neural Wiskott-Aldrich syndrome protein
type: ProteinReference
xref: uniprot O00401 721
xref: PTHR23202:SF39
organism: Homo sapiens

uniprot Q9EQT3 434
type: UnificationXref
id: Q9EQT3
db: uniprot

Myosin heavy chain 7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot F1PWZ2 602
organism: Canis lupus familiaris

uniprot A6QPA6 582
type: UnificationXref
id: A6QPA6
db: uniprot

uniprot Q9HF54 46
type: UnificationXref
id: Q9HF54
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 23

ncbitaxon 559292 29
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot A0A3Q1MX15 384
type: UnificationXref
id: A0A3Q1MX15
db: uniprot

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68033 322
organism: Mus musculus

uniprot A8Y4Q9 200
type: UnificationXref
id: A8Y4Q9
db: uniprot

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot B2RZ72 93
organism: Rattus norvegicus

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: uniprot P68032 321
xref: PTHR11937:SF176
organism: Homo sapiens

Myosin heavy chain 7B
type: ProteinReference
xref: PTHR45615:SF29
xref: uniprot A0A2I3S3U5 574
organism: Pan troglodytes

uniprot H2QNK5 541
type: UnificationXref
id: H2QNK5
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot Q7JJU6 861
xref: PTHR11588:SF61
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G5G3 404
xref: PTHR24347:SF394
organism: Macaca mulatta

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: uniprot P68035 324
xref: PTHR11937:SF176
organism: Rattus norvegicus

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot P68034 323
organism: Gallus gallus

PTHR11588:SF43
type: RelationshipXref
id: PTHR11588:SF43
db: PANTHER Family
relationship type: By Homology

Rac-like GTP-binding protein 5
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot Q6EP31 699
organism: Oryza sativa

PTHR11937:SF193
type: RelationshipXref
id: PTHR11937:SF193
db: PANTHER Family
relationship type: By Homology

Myosin light chain kinase 2
type: ProteinReference
xref: PTHR24347:SF373
xref: uniprot H2QK55 406
organism: Pan troglodytes

uniprot A4GT58 517
type: UnificationXref
id: A4GT58
db: uniprot

Uncharacterized protein racE
type: ProteinReference
xref: uniprot F0ZMZ8 680
organism: Dictyostelium purpureum

PTHR11937:SF192
type: RelationshipXref
id: PTHR11937:SF192
db: PANTHER Family
relationship type: By Homology

uniprot A9RY37 742
type: UnificationXref
id: A9RY37
db: uniprot

eco ECO:0000304 403
type: UnificationXref
id: ECO:0000304
db: eco

MYO3A isoform 1
type: ProteinReference
xref: PTHR46256:SF4
xref: uniprot H2Q1R1 625
organism: Pan troglodytes

uniprot Q62812 658
type: UnificationXref
id: Q62812
db: uniprot

uniprot Q9SJW6 166
type: UnificationXref
id: Q9SJW6
db: uniprot

Tubulin beta-6 chain
type: ProteinReference
xref: uniprot Q922F4 867
xref: PTHR11588:SF88
organism: Mus musculus

uniprot H2QKN9 783
type: UnificationXref
id: H2QKN9
db: uniprot

uniprot Q148F1 64
type: UnificationXref
id: Q148F1
db: uniprot

Myosin-7
type: ProteinReference
xref: PTHR45615:SF1
xref: uniprot Q9BE39 668
organism: Bos taurus

Tubulin beta chain
type: ProteinReference
xref: uniprot F7CB79 773
xref: PTHR11588:SF88
organism: Monodelphis domestica

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60952 425
organism: Canis lupus familiaris

uniprot F1MY55 461
type: UnificationXref
id: F1MY55
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot F6WN02 106
xref: PTHR12644:SF1
organism: Ornithorhynchus anatinus

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60953 426
organism: Homo sapiens

uniprot C3XYC5 220
type: UnificationXref
id: C3XYC5
db: uniprot

PTHR11937:SF184
type: RelationshipXref
id: PTHR11937:SF184
db: PANTHER Family
relationship type: By Homology

uniprot P63268 318
type: UnificationXref
id: P63268
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot Q7PUF2 155
xref: PTHR12391:SF0
organism: Anopheles gambiae

Myosin light chain kinase 3
type: ProteinReference
xref: uniprot H2QB15 405
xref: PTHR24347:SF394
organism: Pan troglodytes

Tubulin beta-4A chain
type: ProteinReference
xref: uniprot P04350 794
xref: PTHR11588:SF253
organism: Homo sapiens

PTHR11588:SF55
type: RelationshipXref
id: PTHR11588:SF55
db: PANTHER Family
relationship type: By Homology

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: PTHR47633:SF1
xref: uniprot Q28824 411
organism: Bos taurus

Cofilin-2
type: ProteinReference
xref: uniprot Q9Y281 68
organism: Homo sapiens

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 19

GTPase cRac1A
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot Q6LC82 701
organism: Gallus gallus

uniprot P63043 398
type: UnificationXref
id: P63043
db: uniprot

uniprot H2Q1A9 273
type: UnificationXref
id: H2Q1A9
db: uniprot

Myosin-1
type: ProteinReference
xref: PTHR45615:SF3
xref: uniprot Q9BE40 669
organism: Bos taurus

uniprot F7DIB7 265
type: UnificationXref
id: F7DIB7
db: uniprot

MLCK
type: Protein
entity reference: MLCK
feature: ACTIVE 48
comment: SPECIES_TYPE=PROTEIN

uniprot Q99323 667
type: UnificationXref
id: Q99323
db: uniprot

uniprot P70460 444
type: UnificationXref
id: P70460
db: uniprot

uniprot E9FZ00 240
type: UnificationXref
id: E9FZ00
db: uniprot

PTHR11588:SF61
type: RelationshipXref
id: PTHR11588:SF61
db: PANTHER Family
relationship type: By Homology

uniprot Q8K330 73
type: UnificationXref
id: Q8K330
db: uniprot

uniprot Q28021 512
type: UnificationXref
id: Q28021
db: uniprot

uniprot F1RAJ1 607
type: UnificationXref
id: F1RAJ1
db: uniprot

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: uniprot O80856 124
xref: PTHR10709:SF2
organism: Arabidopsis thaliana

Tubulin beta-1 chain
type: ProteinReference
xref: uniprot A2AQ07 729
xref: PTHR11588:SF112
organism: Mus musculus

Myosin-7B
type: ProteinReference
xref: uniprot A7E2Y1 583
xref: PTHR45615:SF29
organism: Homo sapiens

Os12g0163700 protein
type: ProteinReference
xref: PTHR11937:SF474
xref: uniprot Q0IPW3 336
organism: Oryza sativa

uniprot H2QV00 115
type: UnificationXref
id: H2QV00
db: uniprot

uniprot F6TWF0 464
type: UnificationXref
id: F6TWF0
db: uniprot

uniprot P23528 59
type: UnificationXref
id: P23528
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot H2QV01 116
xref: PTHR10709:SF10
organism: Pan troglodytes

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot H2QV00 115
xref: PTHR10709:SF11
organism: Pan troglodytes

uniprot F6X673 711
type: UnificationXref
id: F6X673
db: uniprot

Profilin
type: ProteinReference
xref: uniprot F7EGP4 538
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2R481 457
organism: Canis lupus familiaris

Tubulin beta chain (Fragment)
type: ProteinReference
xref: PTHR11588:SF293
xref: uniprot B7Q717 747
organism: Ixodes scapularis

Protein CBR-ACT-2
type: ProteinReference
xref: PTHR11937:SF471
xref: uniprot A8Y4Q9 200
organism: Caenorhabditis briggsae

Tubulin beta chain
type: ProteinReference
xref: uniprot E9FWY0 757
xref: PTHR11588:SF293
organism: Daphnia pulex

uniprot H9G236 505
type: UnificationXref
id: H9G236
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: Axonal plasticity
controller: Cofilin

PTHR12644:SF0
type: RelationshipXref
id: PTHR12644:SF0
db: PANTHER Family
relationship type: By Homology

PTHR12644:SF1
type: RelationshipXref
id: PTHR12644:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P48554 690
type: UnificationXref
id: P48554
db: uniprot

uniprot Q3ZC07 341
type: UnificationXref
id: Q3ZC07
db: uniprot

uniprot C3XYC8 223
type: UnificationXref
id: C3XYC8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot F6ZZG9 261
organism: Monodelphis domestica

MLCK
type: Protein
entity reference: MLCK
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G124 621
xref: PTHR45615:SF11
organism: Macaca mulatta

uniprot W4YJP3 882
type: UnificationXref
id: W4YJP3
db: uniprot

uniprot Q9ERD7 872
type: UnificationXref
id: Q9ERD7
db: uniprot

uniprot Q75BP6 858
type: UnificationXref
id: Q75BP6
db: uniprot

uniprot O42825 24
type: UnificationXref
id: O42825
db: uniprot

Tubulin beta-6 chain
type: ProteinReference
xref: PTHR11588:SF321
xref: uniprot Q76FS3 860
organism: Oryza sativa

Tubulin beta-8 chain
type: ProteinReference
xref: PTHR11588:SF334
xref: uniprot Q76FS2 859
organism: Oryza sativa

uniprot A0A3Q1M0G8 449
type: UnificationXref
id: A0A3Q1M0G8
db: uniprot

uniprot Q9BVA1 869
type: UnificationXref
id: Q9BVA1
db: uniprot

uniprot Q9HF56 435
type: UnificationXref
id: Q9HF56
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A8IXZ0 738
organism: Chlamydomonas reinhardtii

Ras-related protein Rac1
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P40792 689
organism: Drosophila melanogaster

Cdc42 homolog
type: ProteinReference
xref: uniprot P40793 423
xref: PTHR24072:SF192
organism: Drosophila melanogaster

ARP2/3
type: Protein
entity reference: ARP2/3
feature: COMPLEX PARTICIPANT BINDING FEATURE s47 sa14 895
comment: SPECIES_TYPE=PROTEIN

uniprot P63000 692
type: UnificationXref
id: P63000
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot Q3MHR7 146
organism: Bos taurus

Stathmin
type: ProteinReference
xref: uniprot P54227 396
organism: Mus musculus

uniprot P04350 794
type: UnificationXref
id: P04350
db: uniprot

uniprot A8XT67 91
type: UnificationXref
id: A8XT67
db: uniprot

Myosin heavy chain 4
type: ProteinReference
xref: PTHR45615:SF43
xref: uniprot E1BP87 590
organism: Bos taurus

uniprot F6R0F5 608
type: UnificationXref
id: F6R0F5
db: uniprot

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot A0A2I3T5A0 85
xref: PTHR22629:SF0
organism: Pan troglodytes

uniprot P11055 638
type: UnificationXref
id: P11055
db: uniprot

Rho-associated protein kinase 2
type: ProteinReference
xref: uniprot Q62868 513
organism: Rattus norvegicus

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot F7CQJ3 109
xref: PTHR22629:SF0
organism: Xenopus tropicalis

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot O75914 475
organism: Homo sapiens

Probable actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot Q9XWV3 171
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY r44 954
type: Stoichiometry
physical entity: MLCK
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot Q7PUB7 153
xref: PTHR22629:SF0
organism: Anopheles gambiae

Protein diaphanous homolog 1
type: ProteinReference
xref: uniprot O08808 80
organism: Mus musculus

Protein CBG23090
type: ProteinReference
xref: uniprot A8Y4R0 201
xref: PTHR11937:SF470
organism: Caenorhabditis briggsae

PARTICIPANT STOICHIOMETRY r31 934
type: Stoichiometry
physical entity: LIMK
stoichiometric coefficient: 1.0

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot E1C8Y3 96
organism: Gallus gallus

Profilin
type: ProteinReference
xref: uniprot P39825 549
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r31 935
type: Stoichiometry
physical entity: LIMK
stoichiometric coefficient: 1.0

Actin, aortic smooth muscle
type: ProteinReference
xref: uniprot P62736 310
xref: PTHR11937:SF201
organism: Homo sapiens

Profilin-5
type: ProteinReference
xref: uniprot Q9FE63 565
organism: Arabidopsis thaliana

uniprot P38328 135
type: UnificationXref
id: P38328
db: uniprot

uniprot F6T5Y1 502
type: UnificationXref
id: F6T5Y1
db: uniprot

Actin, aortic smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot P62739 312
organism: Bos taurus

uniprot Q5R1X3 350
type: UnificationXref
id: Q5R1X3
db: uniprot

uniprot H2QE24 275
type: UnificationXref
id: H2QE24
db: uniprot

Actin, aortic smooth muscle
type: ProteinReference
xref: uniprot P62737 311
xref: PTHR11937:SF201
organism: Mus musculus

Profilin
type: ProteinReference
xref: uniprot F7DMM7 537
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r35 928
type: Stoichiometry
physical entity: ROCK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r35 929
type: Stoichiometry
physical entity: ROCK
stoichiometric coefficient: 1.0

uniprot P02584 542
type: UnificationXref
id: P02584
db: uniprot

PARTICIPANT STOICHIOMETRY r44 955
type: Stoichiometry
physical entity: MLCK
stoichiometric coefficient: 1.0

uniprot Q92352 160
type: UnificationXref
id: Q92352
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot Q4QQV0 842
xref: PTHR11588:SF88
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__Rac_GTP_-RIGHT__Pi-_Complex__GDP_Rac_-_r16
controller: Rho GAPs

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot Q7YQL4 488
organism: Pan troglodytes

uniprot Q3MHM5 833
type: UnificationXref
id: Q3MHM5
db: uniprot

Tubulin beta 3 class III
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot A0A2K6I1R2 728
organism: Pan troglodytes

uniprot Q812A5 530
type: UnificationXref
id: Q812A5
db: uniprot

Profilin-3
type: ProteinReference
xref: uniprot Q9DAD6 563
organism: Mus musculus

uniprot C3XYC2 217
type: UnificationXref
id: C3XYC2
db: uniprot

uniprot Q07960 526
type: UnificationXref
id: Q07960
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 154

STATE_TRANSITION_LEFT__Complex__GDP_Rac_-RIGHT__Complex__Rac_GTP_-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 936
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 937
left: Complex (GDP/Rac)
interaction type: STATE_TRANSITION
right: Complex (Rac/GTP)

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot E2QWU0 97
organism: Canis lupus familiaris

uniprot Q23862 695
type: UnificationXref
id: Q23862
db: uniprot

uniprot C3YC50 227
type: UnificationXref
id: C3YC50
db: uniprot

uniprot Q9JJV2 567
type: UnificationXref
id: Q9JJV2
db: uniprot

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot P33204 134
organism: Saccharomyces cerevisiae

uniprot Q9VIM5 167
type: UnificationXref
id: Q9VIM5
db: uniprot

Myosin s42 a62 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7D7Y7 775
type: UnificationXref
id: F7D7Y7
db: uniprot

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot Q13153 480
xref: PTHR48015:SF20
organism: Homo sapiens

uniprot P63260 315
type: UnificationXref
id: P63260
db: uniprot

uniprot Q7KQL5 862
type: UnificationXref
id: Q7KQL5
db: uniprot

uniprot F7HTD6 780
type: UnificationXref
id: F7HTD6
db: uniprot

uniprot A0A2I3TL93 86
type: UnificationXref
id: A0A2I3TL93
db: uniprot

uniprot Q6IQX1 659
type: UnificationXref
id: Q6IQX1
db: uniprot

uniprot E2RQT0 709
type: UnificationXref
id: E2RQT0
db: uniprot

Stathmin
type: ProteinReference
evidence: Evidence 386
xref: PTHR10104:SF5
xref: uniprot Q3T0C7 399
organism: Bos taurus

uniprot F7F082 778
type: UnificationXref
id: F7F082
db: uniprot

uniprot E9GYE9 418
type: UnificationXref
id: E9GYE9
db: uniprot

Profilin-3
type: ProteinReference
xref: uniprot Q21193 554
organism: Caenorhabditis elegans

Myosin heavy chain 11
type: ProteinReference
xref: uniprot F1PJ01 600
xref: PTHR45615:SF23
organism: Canis lupus familiaris

uniprot F7BD45 617
type: UnificationXref
id: F7BD45
db: uniprot

uniprot P05219 795
type: UnificationXref
id: P05219
db: uniprot

uniprot A8WTA3 518
type: UnificationXref
id: A8WTA3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF477
xref: uniprot F7A7I3 262
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__Myosin-RIGHT__Myosin-_r43
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 957
participant stoichiometry: PARTICIPANT STOICHIOMETRY r43 956
left: Myosin
interaction type: STATE_TRANSITION
right: Myosin

PARTICIPANT STOICHIOMETRY r16 948
type: Stoichiometry
physical entity: Complex (GDP/Rac)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r16 947
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

Profilin
type: ProteinReference
xref: uniprot H2QNK5 541
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r16 946
type: Stoichiometry
physical entity: Complex (Rac/GTP)
stoichiometric coefficient: 1.0

uniprot P0DM42 287
type: UnificationXref
id: P0DM42
db: uniprot

Profilin-2
type: ProteinReference
xref: uniprot Q42418 558
organism: Arabidopsis thaliana

Rac s18 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__Complex__tubulin_tubulin_-RIGHT__tubulin-_r39
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 923
participant stoichiometry: PARTICIPANT STOICHIOMETRY r39 922
left: Complex (tubulin/tubulin)
interaction type: STATE_TRANSITION
right: tubulin

uniprot A7S8I3 734
type: UnificationXref
id: A7S8I3
db: uniprot

ncbitaxon 185431 340
type: UnificationXref
id: 185431
db: ncbitaxon

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TVP1 204
organism: Physcomitrella patens

uniprot E1C8Y3 96
type: UnificationXref
id: E1C8Y3
db: uniprot

uniprot Q9XW16 568
type: UnificationXref
id: Q9XW16
db: uniprot

PANTHER Pathway P00016 1
type: UnificationXref
id: P00016
db: PANTHER Pathway

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G117 620
xref: PTHR45615:SF44
organism: Macaca mulatta

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PAK
type: ProteinReference
xref: P00517
standard name: p21 activated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: p21 activated kinase Synonym: Synonym not specified Accession: P00517
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.PAK
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: Serine/threonine-protein kinase PAK 6
member entity reference: Serine/threonine-protein kinase PAK 4
member entity reference: Serine/threonine-protein kinase PAK 3
member entity reference: Serine/threonine-protein kinase PAK 5
member entity reference: Serine/threonine-protein kinase PAK 1
member entity reference: Serine/threonine-protein kinase PAK 2
member entity reference: Serine/threonine-protein kinase PAK mbt
member entity reference: Uncharacterized protein
member entity reference: Serine/threonine-protein kinase pak-1

Cdc42
type: Protein
entity reference: Cdc42
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa12 919
comment: SPECIES_TYPE=PROTEIN

uniprot F7D0R0 53
type: UnificationXref
id: F7D0R0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot F7ES59 20
organism: Monodelphis domestica

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q90694 433
organism: Gallus gallus

uniprot Q076A6 651
type: UnificationXref
id: Q076A6
db: uniprot

Ena/VASP-like protein
type: ProteinReference
xref: uniprot O08719 440
organism: Rattus norvegicus

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: PTHR47633:SF1
xref: uniprot P11799 407
organism: Gallus gallus

uniprot F1MQ37 593
type: UnificationXref
id: F1MQ37
db: uniprot

Tubulin beta-2B chain
type: ProteinReference
xref: PTHR11588:SF375
xref: uniprot Q6B856 846
organism: Bos taurus

uniprot F6UA63 258
type: UnificationXref
id: F6UA63
db: uniprot

uniprot P59999 139
type: UnificationXref
id: P59999
db: uniprot

uniprot A9SJR1 743
type: UnificationXref
id: A9SJR1
db: uniprot

uniprot O96624 130
type: UnificationXref
id: O96624
db: uniprot

uniprot P34148 688
type: UnificationXref
id: P34148
db: uniprot

Op18/stathmin
type: Protein
entity reference: Op18/stathmin
feature: S16 Op18 stathmin s39 a59 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot Q9H4B7 873
type: UnificationXref
id: Q9H4B7
db: uniprot

uniprot F1P9J3 599
type: UnificationXref
id: F1P9J3
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A2G1K5 182
organism: Trichomonas vaginalis

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NM49 597
xref: PTHR45615:SF26
organism: Gallus gallus

uniprot Q64303 487
type: UnificationXref
id: Q64303
db: uniprot

uniprot Q32PB1 555
type: UnificationXref
id: Q32PB1
db: uniprot

PTHR24072:SF192
type: RelationshipXref
id: PTHR24072:SF192
db: PANTHER Family
relationship type: By Homology

Actin-2
type: ProteinReference
xref: uniprot Q8ILW9 372
xref: PTHR11937:SF387
organism: Plasmodium falciparum

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot Q9VMH2 168
organism: Drosophila melanogaster

PTHR45808:SF6
type: RelationshipXref
id: PTHR45808:SF6
db: PANTHER Family
relationship type: By Homology

uniprot P60712 309
type: UnificationXref
id: P60712
db: uniprot

uniprot A8IXZ0 738
type: UnificationXref
id: A8IXZ0
db: uniprot

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa6 909
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P41799 813
type: UnificationXref
id: P41799
db: uniprot

uniprot F7FKL1 470
type: UnificationXref
id: F7FKL1
db: uniprot

uniprot Q75D00 363
type: UnificationXref
id: Q75D00
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot F6XSJ9 683
organism: Macaca mulatta

uniprot Q9BE40 669
type: UnificationXref
id: Q9BE40
db: uniprot

uniprot A7E2Y1 583
type: UnificationXref
id: A7E2Y1
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 31

uniprot Q5SX39 655
type: UnificationXref
id: Q5SX39
db: uniprot

Myosin light chain kinase, smooth muscle
type: ProteinReference
xref: PTHR47633:SF1
xref: uniprot Q15746 409
organism: Homo sapiens

LIM domain kinase 1
type: ProteinReference
xref: uniprot F6RZQ1 710
organism: Xenopus tropicalis

Actin-1
type: ProteinReference
xref: uniprot P0DM41 286
xref: PTHR11937:SF387
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MQ37 593
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Cofilin-RIGHT__Cofilin-_r34
controller: LIMK

Actin
type: ProteinReference
xref: uniprot A2FA04 180
xref: PTHR11937:SF387
organism: Trichomonas vaginalis

uniprot F6PGG2 52
type: UnificationXref
id: F6PGG2
db: uniprot

Rac s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

uniprot P41937 814
type: UnificationXref
id: P41937
db: uniprot

uniprot P60952 425
type: UnificationXref
id: P60952
db: uniprot

ncbitaxon 418459 237
type: UnificationXref
id: 418459
db: ncbitaxon

Rho-related protein racE
type: ProteinReference
xref: uniprot Q23862 695
organism: Dictyostelium discoideum

PARTICIPANT STOICHIOMETRY r23 966
type: Stoichiometry
physical entity: Complex (Profilin/Actin)
stoichiometric coefficient: 1.0

uniprot Q4QQV0 842
type: UnificationXref
id: Q4QQV0
db: uniprot

uniprot F7CQJ3 109
type: UnificationXref
id: F7CQJ3
db: uniprot

PARTICIPANT STOICHIOMETRY r23 965
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 1.0

uniprot P63258 313
type: UnificationXref
id: P63258
db: uniprot

uniprot P16949 392
type: UnificationXref
id: P16949
db: uniprot

PARTICIPANT STOICHIOMETRY r23 968
type: Stoichiometry
physical entity: Complex (Actin/Actin)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 967
type: Stoichiometry
physical entity: Profilin
stoichiometric coefficient: 1.0

uniprot Q9P286 493
type: UnificationXref
id: Q9P286
db: uniprot

uniprot F7E2I0 719
type: UnificationXref
id: F7E2I0
db: uniprot

uniprot P50551 441
type: UnificationXref
id: P50551
db: uniprot

Tubulin beta-3 chain
type: ProteinReference
xref: PTHR11588:SF395
xref: uniprot Q40665 836
organism: Oryza sativa

Myosin, heavy chain b
type: ProteinReference
xref: uniprot F1QVX3 604
organism: Danio rerio

uniprot F7FR08 22
type: UnificationXref
id: F7FR08
db: uniprot

uniprot Q3ULB5 484
type: UnificationXref
id: Q3ULB5
db: uniprot

uniprot F1PYS6 603
type: UnificationXref
id: F1PYS6
db: uniprot

uniprot F6SCP4 254
type: UnificationXref
id: F6SCP4
db: uniprot

PTHR10709:SF10
type: RelationshipXref
id: PTHR10709:SF10
db: PANTHER Family
relationship type: By Homology

uniprot Q24560 828
type: UnificationXref
id: Q24560
db: uniprot

PTHR10709:SF11
type: RelationshipXref
id: PTHR10709:SF11
db: PANTHER Family
relationship type: By Homology

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

uniprot F6RH86 609
type: UnificationXref
id: F6RH86
db: uniprot

PTHR24072:SF168
type: RelationshipXref
id: PTHR24072:SF168
db: PANTHER Family
relationship type: By Homology

uniprot F0ZK40 243
type: UnificationXref
id: F0ZK40
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF453
xref: uniprot W4Y969 381
organism: Strongylocentrotus purpuratus

Uncharacterized protein (Fragment)
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot C3YPV2 94
organism: Branchiostoma floridae

uniprot Q17031 428
type: UnificationXref
id: Q17031
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3S5ZPV2 438
organism: Gallus gallus

uniprot P37832 812
type: UnificationXref
id: P37832
db: uniprot

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

Rho-associated protein kinase
type: ProteinReference
xref: uniprot F6T5Y1 502
xref: PTHR22988:SF33
organism: Macaca mulatta

Actin-12
type: ProteinReference
xref: PTHR11937:SF434
xref: uniprot P53497 302
organism: Arabidopsis thaliana

ncbitaxon 684364 765
type: UnificationXref
id: 684364
db: ncbitaxon

N-WASP
type: Protein
entity reference: N-WASP
feature: ACTIVE 48
feature: COMPLEX PARTICIPANT BINDING FEATURE s46 sa13 893
comment: SPECIES_TYPE=PROTEIN

Actin-4
type: ProteinReference
xref: PTHR11937:SF438
xref: uniprot P53494 301
organism: Arabidopsis thaliana

Profilin
type: Protein
entity reference: Profilin
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa17 903
comment: SPECIES_TYPE=PROTEIN

Actin-7
type: ProteinReference
xref: uniprot P53492 300
xref: PTHR11937:SF483
organism: Arabidopsis thaliana

uniprot F7FAW0 619
type: UnificationXref
id: F7FAW0
db: uniprot

ACTin
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot O45815 279
organism: Caenorhabditis elegans

MLCK
type: ProteinReference
xref: P00514
standard name: Myosin light chain kinase
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.MLCK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Myosin light chain kinase Synonym: MYLK Accession: P00514
member entity reference: Myosin light chain kinase 2, skeletal/cardiac muscle
member entity reference: Uncharacterized protein
member entity reference: Myosin light chain kinase
member entity reference: Myosin light chain kinase 3
member entity reference: Myosin light chain kinase, smooth muscle
member entity reference: Myosin light chain kinase 2
member entity reference: Myosin Light Chain Kinase related

uniprot H2R9J3 631
type: UnificationXref
id: H2R9J3
db: uniprot

ncbitaxon 7227 33
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot Q5ZMQ2 351
type: UnificationXref
id: Q5ZMQ2
db: uniprot

uniprot B8A569 588
type: UnificationXref
id: B8A569
db: uniprot

uniprot C3XZ13 226
type: UnificationXref
id: C3XZ13
db: uniprot

Novel actin protein
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot Q6IQL9 356
organism: Danio rerio

Myosin IIIB
type: ProteinReference
xref: PTHR46256:SF1
xref: uniprot H2QZG8 630
organism: Pan troglodytes

Rho guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR45872:SF4
xref: uniprot Q92888 497
organism: Homo sapiens

Rho-associated protein kinase
type: ProteinReference
xref: uniprot K7AX49 506
organism: Pan troglodytes

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q7TMM9 864
type: UnificationXref
id: Q7TMM9
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot J9P309 118
xref: PTHR12391:SF4
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2TTH6 500
organism: Gallus gallus

Tubulin beta-4A chain
type: ProteinReference
xref: uniprot Q3ZBU7 834
xref: PTHR11588:SF253
organism: Bos taurus

Serine/threonine-protein kinase PAK 5
type: ProteinReference
xref: uniprot Q9P286 493
organism: Homo sapiens

uniprot Q5A786 559
type: UnificationXref
id: Q5A786
db: uniprot

uniprot A5D7J5 415
type: UnificationXref
id: A5D7J5
db: uniprot

uniprot O15144 121
type: UnificationXref
id: O15144
db: uniprot

uniprot E9FXV8 239
type: UnificationXref
id: E9FXV8
db: uniprot

Actin, cytoplasmic type 5
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot P53478 299
organism: Gallus gallus

ENAH, actin regulator
type: ProteinReference
xref: uniprot A0A0G2K6I4 436
organism: Rattus norvegicus

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 887
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Tubulin beta-4 chain
type: ProteinReference
xref: uniprot P41937 814
xref: PTHR11588:SF279
organism: Caenorhabditis elegans

uniprot F7F009 389
type: UnificationXref
id: F7F009
db: uniprot

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 403

Tubulin beta-6 chain
type: ProteinReference
xref: uniprot Q2HJ81 829
xref: PTHR11588:SF88
organism: Bos taurus

uniprot Q7PUB7 153
type: UnificationXref
id: Q7PUB7
db: uniprot

uniprot P45960 815
type: UnificationXref
id: P45960
db: uniprot

ncbitaxon 81824 209
type: UnificationXref
id: 81824
db: ncbitaxon

uniprot F6THF0 682
type: UnificationXref
id: F6THF0
db: uniprot

uniprot P63270 320
type: UnificationXref
id: P63270
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MLCK-RIGHT__MLCK-_r44
controller: ROCK

Actin, cytoskeletal 3A
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P53474 298
organism: Strongylocentrotus purpuratus

Complex (Cdc42/GTP)
type: Complex
component stoichiometry: Cdc42 s14 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s15 sa6 STOICHIOMETRY ID COMPLEX
component: Cdc42
component: GTP
feature: COMPLEX BINDING FEATURE s20 a29 906
feature: COMPLEX BINDING FEATURE s20 a29 908

Actin
type: ProteinReference
xref: uniprot B3RKR4 212
xref: PTHR11937:SF387
organism: Trichoplax adhaerens

uniprot P15153 685
type: UnificationXref
id: P15153
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q10316 143
organism: Schizosaccharomyces pombe

uniprot E2QSF4 753
type: UnificationXref
id: E2QSF4
db: uniprot

Tubulin beta-6 chain
type: ProteinReference
xref: uniprot P09207 799
xref: PTHR11588:SF112
organism: Gallus gallus

uniprot D3ZQ51 452
type: UnificationXref
id: D3ZQ51
db: uniprot

uniprot Q91Z83 666
type: UnificationXref
id: Q91Z83
db: uniprot

Tubulin beta-3 chain
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot Q4QRB4 843
organism: Rattus norvegicus

ROCK
type: Protein
entity reference: ROCK
comment: SPECIES_TYPE=PROTEIN

Tubulin beta chain
type: ProteinReference
xref: uniprot H3DZP3 787
xref: PTHR11588:SF357
organism: Pristionchus pacificus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF357
xref: uniprot H3DZP2 786
organism: Pristionchus pacificus

Neither inactivation nor afterpotential protein C
type: ProteinReference
xref: uniprot P10676 637
organism: Drosophila melanogaster

PTHR12058:SF0
type: RelationshipXref
id: PTHR12058:SF0
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YKS6 228
organism: Branchiostoma floridae

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot Q6IQJ2 848
organism: Danio rerio

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot G5EF01 782
organism: Caenorhabditis elegans

uniprot Q8I4X0 370
type: UnificationXref
id: Q8I4X0
db: uniprot

uniprot Q4Q4C4 839
type: UnificationXref
id: Q4Q4C4
db: uniprot

uniprot F6XSJ9 683
type: UnificationXref
id: F6XSJ9
db: uniprot

uniprot F7GE67 622
type: UnificationXref
id: F7GE67
db: uniprot

PARTICIPANT STOICHIOMETRY r27 962
type: Stoichiometry
physical entity: Profilin
stoichiometric coefficient: 1.0

Actin, beta-like 2
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot D3ZRN3 235
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r27 963
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 1.0

ncbitaxon 3218 203
type: UnificationXref
id: 3218
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r27 964
type: Stoichiometry
physical entity: Complex (Profilin/Actin)
stoichiometric coefficient: 1.0

Actin, putative (Fragment)
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B7PBG2 215
organism: Ixodes scapularis

Probable actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot P58798 137
xref: PTHR22629:SF0
organism: Caenorhabditis elegans

uniprot H2RB52 785
type: UnificationXref
id: H2RB52
db: uniprot

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__tubulin_tubulin_-RIGHT__tubulin-_r39
controller: Op18/stathmin

Op18/stathmin
type: Protein
entity reference: Op18/stathmin
feature: ACTIVE 48
feature: S16 Op18 stathmin s38 a58 rs1
comment: SPECIES_TYPE=PROTEIN

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F7BAS2 468
organism: Ornithorhynchus anatinus

Myosin-2
type: ProteinReference
xref: PTHR45615:SF39
xref: uniprot Q9UKX2 671
organism: Homo sapiens

uniprot Q7ZVI7 368
type: UnificationXref
id: Q7ZVI7
db: uniprot

uniprot Q9JLT0 670
type: UnificationXref
id: Q9JLT0
db: uniprot

Myosin-13
type: ProteinReference
xref: uniprot Q9UKX3 672
xref: PTHR45615:SF44
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot C3YC50 227
xref: PTHR11937:SF446
organism: Branchiostoma floridae

PTHR24072:SF100
type: RelationshipXref
id: PTHR24072:SF100
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9606 31
type: UnificationXref
id: 9606
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR11202:SF12
xref: uniprot F6U702 439
organism: Macaca mulatta

uniprot P12882 639
type: UnificationXref
id: P12882
db: uniprot

Candida albicans
type: BioSource
xref: ncbitaxon 237561 25

Myosin heavy chain 6
type: ProteinReference
xref: uniprot A0A2I3TIW8 576
xref: PTHR45615:SF11
organism: Pan troglodytes

Stathmin
type: ProteinReference
xref: uniprot F7F009 389
organism: Ornithorhynchus anatinus

uniprot A8WS37 198
type: UnificationXref
id: A8WS37
db: uniprot

N WASP s46 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: N-WASP
stoichiometric coefficient: 1.0

uniprot F1QKY8 762
type: UnificationXref
id: F1QKY8
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot E2RFV2 755
xref: PTHR11588:SF253
organism: Canis lupus familiaris

uniprot F7DQK7 266
type: UnificationXref
id: F7DQK7
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot L7N3Q3 791
xref: PTHR11588:SF88
organism: Xenopus tropicalis

WASL isoform 1
type: ProteinReference
xref: uniprot H2QVA9 720
xref: PTHR23202:SF39
organism: Pan troglodytes

Leishmania major
type: BioSource
xref: ncbitaxon 5664 377

uniprot P68139 329
type: UnificationXref
id: P68139
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TUR3 256
xref: PTHR11937:SF192
organism: Monodelphis domestica

uniprot E9HL06 16
type: UnificationXref
id: E9HL06
db: uniprot

uniprot P35580 646
type: UnificationXref
id: P35580
db: uniprot

uniprot P68035 324
type: UnificationXref
id: P68035
db: uniprot

uniprot E9HGF5 241
type: UnificationXref
id: E9HGF5
db: uniprot

Serine/threonine-protein kinase PAK 6
type: ProteinReference
xref: uniprot Q3ULB5 484
organism: Mus musculus

Myosin heavy chain 4
type: ProteinReference
xref: uniprot A2BGX6 580
xref: PTHR45615:SF44
organism: Danio rerio

PTHR11588:SF247
type: RelationshipXref
id: PTHR11588:SF247
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR46256:SF1
xref: uniprot F7GE67 622
organism: Macaca mulatta

Tubulin beta-7 chain
type: ProteinReference
xref: PTHR11588:SF61
xref: uniprot P09244 800
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot H2KNE6 271
xref: PTHR11937:SF387
organism: Phaeosphaeria nodorum

uniprot F1A084 681
type: UnificationXref
id: F1A084
db: uniprot

Muscle-specific actin
type: ProteinReference
xref: PTHR11937:SF162
xref: uniprot E9FRT1 238
organism: Daphnia pulex

uniprot F6QTB5 104
type: UnificationXref
id: F6QTB5
db: uniprot

uniprot F6RZQ1 710
type: UnificationXref
id: F6RZQ1
db: uniprot

uniprot P48148 32
type: UnificationXref
id: P48148
db: uniprot

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: uniprot Q13177 481
xref: PTHR48015:SF22
organism: Homo sapiens

ncbitaxon 665079 9
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot F2Z4P1 763
type: UnificationXref
id: F2Z4P1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DQK7 266
xref: PTHR11937:SF201
organism: Monodelphis domestica

Actin 7
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TBG2 202
organism: Physcomitrella patens

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot Q5ZJI7 151
organism: Gallus gallus

Rho
type: Protein
entity reference: Rho
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa10 891
comment: SPECIES_TYPE=PROTEIN

Cdc42
type: ProteinReference
xref: P00515
standard name: Cell division cycle 42
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Cdc42
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Cell division control protein 42 homolog
member entity reference: Rho-related GTP-binding protein RhoU
member entity reference: Cell division cycle 42
member entity reference: Uncharacterized protein
member entity reference: Cell division control protein 42 homolog isoform 2
member entity reference: Cdc42 homolog
member entity reference: Cdc42 protein, putative
member entity reference: Cell division control protein 42

Actin
type: ProteinReference
xref: uniprot Q5KP06 347
xref: PTHR11937:SF387
organism: Cryptococcus neoformans

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot W4YJP3 882
organism: Strongylocentrotus purpuratus

Actin, gamma-enteric smooth muscle
type: ProteinReference
xref: uniprot Q5E9B5 346
xref: PTHR11937:SF201
organism: Bos taurus

uniprot Q2KJD0 830
type: UnificationXref
id: Q2KJD0
db: uniprot

Actin, alpha skeletal muscle
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot P68134 326
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__GDP_Rho_-RIGHT__Complex__Rho_GTP_-_r18
controller: Rho GEFs

STATE_TRANSITION_LEFT__ROCK-RIGHT__ROCK-_r35
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 928
participant stoichiometry: PARTICIPANT STOICHIOMETRY r35 929
left: ROCK
interaction type: STATE_TRANSITION
right: ROCK

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68133 325
xref: PTHR11937:SF193
organism: Homo sapiens

Tubulin beta-5 chain
type: ProteinReference
xref: uniprot P09653 802
xref: PTHR11588:SF88
organism: Gallus gallus

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68136 327
xref: PTHR11937:SF193
organism: Rattus norvegicus

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68138 328
xref: PTHR11937:SF193
organism: Bos taurus

Tubulin beta-4 chain
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot P09652 801
organism: Gallus gallus

uniprot F6ZCX3 771
type: UnificationXref
id: F6ZCX3
db: uniprot

uniprot P40518 136
type: UnificationXref
id: P40518
db: uniprot

Actin, alpha skeletal muscle
type: ProteinReference
xref: uniprot P68139 329
xref: PTHR11937:SF193
organism: Gallus gallus

Cytoskeletal regulation by Rho GTPase
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Complex__tubulin_tubulin_-RIGHT__tubulin-_r39
pathway component: STATE_TRANSITION_LEFT__MLCK-RIGHT__MLCK-_r44
pathway component: STATE_TRANSITION_LEFT__Complex__Actin_Actin_-RIGHT__Actin-_r29
pathway component: STATE_TRANSITION_LEFT__Complex__Cdc42_GTP_-RIGHT__Pi-_Complex__GDP_Cdc42_-_r17
pathway component: MODULATION
pathway component: STATE_TRANSITION_LEFT__Complex__GDP_Rho_-RIGHT__Complex__Rho_GTP_-_r18
pathway component: STATE_TRANSITION_LEFT__Cofilin-RIGHT__Cofilin-_r36
pathway component: HETERODIMER_ASSOCIATION_LEFT__Profilin-_Actin-RIGHT__Complex__Profilin_Actin_-_r27
pathway component: STATE_TRANSITION_LEFT__mDia-RIGHT__mDia-_r45
pathway component: STATE_TRANSITION_LEFT__tubulin-RIGHT__Complex__tubulin_tubulin_-_r38
pathway component: STATE_TRANSITION_LEFT__Myosin-RIGHT__Myosin-_r43
pathway component: STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r33
pathway component: STATE_TRANSITION_LEFT__Op18_stathmin-RIGHT__Op18_stathmin-_r40
pathway component: STATE_TRANSITION_LEFT__Cofilin-RIGHT__Cofilin-_r34
pathway component: STATE_TRANSITION_LEFT__Complex__Rac_GTP_-RIGHT__Pi-_Complex__GDP_Rac_-_r16
pathway component: STATE_TRANSITION_LEFT__LIMK-RIGHT__LIMK-_r31
pathway component: STATE_TRANSITION_LEFT__ROCK-RIGHT__ROCK-_r35
pathway component: HETERODIMER_ASSOCIATION_LEFT__ARP2_3-_N_WASP-RIGHT__Complex__N_WASP_ARP2__3_-_r48
pathway component: STATE_TRANSITION_LEFT__Complex__Rho_GTP_-RIGHT__Complex__GDP_Rho_-_Pi-_r15
pathway component: STATE_TRANSITION_LEFT__Complex__GDP_Cdc42_-RIGHT__Complex__Cdc42_GTP_-_r20
pathway component: STATE_TRANSITION_LEFT__Actin-_Complex__Profilin_Actin_-RIGHT__Profilin-_Complex__Actin_Actin_-_r23
pathway component: STATE_TRANSITION_LEFT__Complex__GDP_Rac_-RIGHT__Complex__Rac_GTP_-_r19
xref: PANTHER Pathway P00016 1
comment: MODEL_NOTES=Panther Pathway: P00016 Actin and microtubules are major cytoskeletal elements of most cells including neurons. In order for a cell to move and change shape, its cytoskeleton must undergo rearrangements that involve breaking down and reforming filaments. This pathway illustrates such change regulated by Rho GTPase. Medline=12677003 Medline=12796474 Medline=14598374 PMID: 12677003 PMID: 12796474 PMID: 14598374

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C3YJC1 676
organism: Branchiostoma floridae

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot B5DF62 451
organism: Rattus norvegicus

uniprot P53668 713
type: UnificationXref
id: P53668
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot P41799 813
organism: Phaeosphaeria nodorum

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: uniprot Q64303 487
xref: PTHR48015:SF22
organism: Rattus norvegicus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF100
xref: uniprot F7FFR0 779
organism: Ornithorhynchus anatinus

Melanocyte-stimulating hormone receptor
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot F7D7Y7 775
organism: Macaca mulatta

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63001 693
xref: PTHR24072:SF105
organism: Mus musculus

uniprot P18499 293
type: UnificationXref
id: P18499
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63000 692
xref: PTHR24072:SF105
organism: Homo sapiens

Myosin IIIA
type: ProteinReference
xref: PTHR46256:SF4
xref: uniprot F1RAJ1 607
organism: Danio rerio

Giardia intestinalis
type: BioSource
xref: ncbitaxon 184922 193

uniprot F6XUP1 466
type: UnificationXref
id: F6XUP1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UVG3 69
organism: Macaca mulatta

uniprot P68138 328
type: UnificationXref
id: P68138
db: uniprot

Tubulin beta-1 chain
type: ProteinReference
xref: uniprot P12411 805
xref: PTHR11588:SF116
organism: Arabidopsis thaliana

uniprot Q01112 427
type: UnificationXref
id: Q01112
db: uniprot

PTHR11937:SF201
type: RelationshipXref
id: PTHR11937:SF201
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5RJ31 84
type: UnificationXref
id: A0A1D5RJ31
db: uniprot

Profilin-2
type: ProteinReference
xref: uniprot P26200 547
organism: Dictyostelium discoideum

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P60010 304
organism: Saccharomyces cerevisiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__tubulin-RIGHT__Complex__tubulin_tubulin_-_r38
controller: mDia

Tubulin beta-4B chain
type: ProteinReference
xref: uniprot Q6P9T8 852
xref: PTHR11588:SF247
organism: Rattus norvegicus

Profilin-2
type: ProteinReference
xref: uniprot Q9JJV2 567
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XUU0 260
organism: Monodelphis domestica

Myosin, heavy polypeptide 1.2, skeletal muscle
type: ProteinReference
xref: uniprot B8A561 586
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GY91 684
xref: PTHR24072:SF325
organism: Macaca mulatta

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF1
xref: uniprot F6X9N6 107
organism: Monodelphis domestica

S3 Cofilin s10 a10 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S3
feature location: S3 Cofilin s10 a10 rs1 S3
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793
comment: MODIFICATION_RESIDUE_NAME=S3

PARTICIPANT STOICHIOMETRY r15 950
type: Stoichiometry
physical entity: Complex (GDP/Rho)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 951
type: Stoichiometry
physical entity: Pi
stoichiometric coefficient: 1.0

uniprot A9TYG6 206
type: UnificationXref
id: A9TYG6
db: uniprot

uniprot P63261 316
type: UnificationXref
id: P63261
db: uniprot

Cell division cycle 42
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q28BZ0 429
organism: Xenopus tropicalis

Stathmin
type: ProteinReference
evidence: Evidence 386
xref: PTHR10104:SF5
xref: uniprot J9NVP2 390
organism: Canis lupus familiaris

Myosin heavy chain 2
type: ProteinReference
xref: PTHR45615:SF39
xref: uniprot H2QC99 628
organism: Pan troglodytes

uniprot F1P1K3 101
type: UnificationXref
id: F1P1K3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF35
xref: uniprot H2QC98 627
organism: Pan troglodytes

Myosin heavy chain 13
type: ProteinReference
xref: uniprot H2QC97 626
xref: PTHR45615:SF44
organism: Pan troglodytes

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot P08134 30
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__ARP2_3-_N_WASP-RIGHT__Complex__N_WASP_ARP2__3_-_r48
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 940
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 941
participant stoichiometry: PARTICIPANT STOICHIOMETRY r48 942
left: ARP2/3
left: N-WASP
interaction type: HETERODIMER_ASSOCIATION
right: Complex (N-WASP/ARP2/ 3)

Actin, alpha cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot Q6P640 359
organism: Xenopus tropicalis

Tubulin beta chain
type: ProteinReference
xref: uniprot O17921 792
xref: PTHR11588:SF404
organism: Caenorhabditis elegans

uniprot P10984 289
type: UnificationXref
id: P10984
db: uniprot

uniprot Q17850 482
type: UnificationXref
id: Q17850
db: uniprot

Os05g0106600 protein
type: ProteinReference
xref: uniprot Q65XH8 352
xref: PTHR11937:SF464
organism: Oryza sativa

Actin
type: ProteinReference
xref: P00512
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Actin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Actin Synonym: Synonym not specified Accession: P00512
member entity reference: Actin related protein
member entity reference: ACTin
member entity reference: Predicted protein
member entity reference: Protein CBG02162
member entity reference: Actin, gamma-enteric smooth muscle
member entity reference: Actin-2
member entity reference: Actin
member entity reference: Uncharacterized protein
member entity reference: Actin, cytoplasmic 2
member entity reference: Actin, cytoplasmic 1
member entity reference: Os12g0163700 protein
member entity reference: Actin-1
member entity reference: Actin, aortic smooth muscle
member entity reference: Protein CBG02167
member entity reference: Actin 5
member entity reference: Actin, alpha cardiac muscle 1
member entity reference: Actin, alpha, cardiac muscle 1a
member entity reference: Alpha-cardiac actin
member entity reference: ACTC1 isoform 1
member entity reference: Protein CBR-ACT-5
member entity reference: Actin-4
member entity reference: Actin-5C
member entity reference: Actin-10
member entity reference: ACTA1 isoform 1
member entity reference: Actin-3
member entity reference: Actin, muscle
member entity reference: actin, muscle-like
member entity reference: Actin, larval muscle
member entity reference: Actin-42A
member entity reference: Putative actin-23
member entity reference: Beta-actin-like protein 2
member entity reference: Actin-like protein 53D
member entity reference: Actin, cytoskeletal 3B

Rho GAPs
type: Protein
entity reference: Rho GAPs
comment: SPECIES_TYPE=PROTEIN

uniprot W4XVG8 878
type: UnificationXref
id: W4XVG8
db: uniprot

uniprot F7CU42 469
type: UnificationXref
id: F7CU42
db: uniprot

ncbitaxon 321614 272
type: UnificationXref
id: 321614
db: ncbitaxon

Myosin, heavy polypeptide 1.1, skeletal muscle
type: ProteinReference
xref: uniprot B8A568 587
organism: Danio rerio

uniprot P10986 290
type: UnificationXref
id: P10986
db: uniprot

PAK
type: Protein
entity reference: PAK
comment: SPECIES_TYPE=PROTEIN

Myosin, heavy polypeptide 1.3, skeletal muscle
type: ProteinReference
xref: uniprot B8A569 588
organism: Danio rerio

uniprot Q15746 409
type: UnificationXref
id: Q15746
db: uniprot

ARHGEF1 isoform 4
type: ProteinReference
xref: uniprot H2QGF2 495
xref: PTHR45872:SF4
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r15 949
type: Stoichiometry
physical entity: Complex (Rho/GTP)
stoichiometric coefficient: 1.0

uniprot Q6DHS1 354
type: UnificationXref
id: Q6DHS1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BTH9 717
xref: PTHR23202:SF39
organism: Gallus gallus

uniprot F7BAS2 468
type: UnificationXref
id: F7BAS2
db: uniprot

uniprot P07828 282
type: UnificationXref
id: P07828
db: uniprot

uniprot A8XX81 740
type: UnificationXref
id: A8XX81
db: uniprot

uniprot Q09430 553
type: UnificationXref
id: Q09430
db: uniprot

Actin
type: ProteinReference
xref: uniprot Q9U1E8 376
xref: PTHR11937:SF387
organism: Leishmania major

uniprot Q7ZWH4 159
type: UnificationXref
id: Q7ZWH4
db: uniprot

Cofilin-1
type: ProteinReference
xref: uniprot Q5E9F7 65
organism: Bos taurus

uniprot D4A6C5 519
type: UnificationXref
id: D4A6C5
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q7KQL5 862
organism: Plasmodium falciparum

uniprot C3Y2F5 750
type: UnificationXref
id: C3Y2F5
db: uniprot

Rac-like GTP-binding protein 6
type: ProteinReference
xref: uniprot Q6ZHA3 703
xref: PTHR24072:SF287
organism: Oryza sativa

Profilin-3
type: ProteinReference
xref: uniprot P60673 550
organism: Homo sapiens

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 3

Serine/threonine-protein kinase PAK 2
type: ProteinReference
xref: uniprot Q8CIN4 491
xref: PTHR48015:SF22
organism: Mus musculus

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot Q5M8T9 349
organism: Xenopus tropicalis

Cofilin-2
type: ProteinReference
xref: uniprot P21566 58
organism: Gallus gallus

Tubulin beta chain
type: ProteinReference
xref: uniprot Q6P5M9 851
xref: PTHR11588:SF247
organism: Danio rerio

uniprot F6RWK1 520
type: UnificationXref
id: F6RWK1
db: uniprot

uniprot Q6XNL8 362
type: UnificationXref
id: Q6XNL8
db: uniprot

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: uniprot O88656 126
xref: PTHR10709:SF10
organism: Rattus norvegicus

Stathmin-4
type: ProteinReference
xref: uniprot P63042 397
organism: Mus musculus

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: PTHR10709:SF10
xref: uniprot Q58CQ2 150
organism: Bos taurus

Stathmin-4
type: ProteinReference
xref: uniprot P63043 398
organism: Rattus norvegicus

Actin-2
type: ProteinReference
xref: uniprot A3C6D7 184
xref: PTHR11937:SF410
organism: Oryza sativa

uniprot Q4GYY6 838
type: UnificationXref
id: Q4GYY6
db: uniprot

GTP s9 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot H2QBZ3 540
type: UnificationXref
id: H2QBZ3
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A9RY37 742
organism: Physcomitrella patens

Cofilin
type: Protein
entity reference: Cofilin
feature: ACTIVE 48
feature: S3 Cofilin s10 a10 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot A7RRG4 88
type: UnificationXref
id: A7RRG4
db: uniprot

uniprot Q38E94 339
type: UnificationXref
id: Q38E94
db: uniprot

uniprot Q02566 648
type: UnificationXref
id: Q02566
db: uniprot

ACTIVE 48
type: EntityFeature
comment: Active state

Myosin-11
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot P35749 647
organism: Homo sapiens

uniprot O60610 81
type: UnificationXref
id: O60610
db: uniprot

uniprot Q8RYC2 373
type: UnificationXref
id: Q8RYC2
db: uniprot

uniprot Q7PRV2 515
type: UnificationXref
id: Q7PRV2
db: uniprot

uniprot B7PA95 746
type: UnificationXref
id: B7PA95
db: uniprot

uniprot P13533 641
type: UnificationXref
id: P13533
db: uniprot

uniprot Q6GLE7 847
type: UnificationXref
id: Q6GLE7
db: uniprot

uniprot Q8WP14 866
type: UnificationXref
id: Q8WP14
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: uniprot O96623 129
organism: Dictyostelium discoideum

uniprot Q5E9F7 65
type: UnificationXref
id: Q5E9F7
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot O96624 130
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XZ13 226
organism: Branchiostoma floridae

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot O96625 131
organism: Dictyostelium discoideum

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: PTHR12644:SF0
xref: uniprot O96626 132
organism: Dictyostelium discoideum

uniprot Q9Y281 68
type: UnificationXref
id: Q9Y281
db: uniprot

uniprot F6WN02 106
type: UnificationXref
id: F6WN02
db: uniprot

Actin-related protein 2/3 complex subunit 1
type: ProteinReference
xref: uniprot O96622 127
xref: PTHR10709:SF2
organism: Dictyostelium discoideum

uniprot F2Z4N8 250
type: UnificationXref
id: F2Z4N8
db: uniprot

tubulin
type: Protein
entity reference: tubulin
comment: SPECIES_TYPE=PROTEIN

uniprot P24636 807
type: UnificationXref
id: P24636
db: uniprot

uniprot Q6TYR5 854
type: UnificationXref
id: Q6TYR5
db: uniprot

uniprot A0A1W2WEN5 176
type: UnificationXref
id: A0A1W2WEN5
db: uniprot

uniprot Q5E9B5 346
type: UnificationXref
id: Q5E9B5
db: uniprot

Profilin s50 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Profilin
stoichiometric coefficient: 1.0

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF404
xref: uniprot A8XSF1 739
organism: Caenorhabditis briggsae

uniprot O08638 632
type: UnificationXref
id: O08638
db: uniprot

Neural Wiskott-Aldrich syndrome protein
type: ProteinReference
xref: PTHR23202:SF39
xref: uniprot Q91YD9 722
organism: Mus musculus

uniprot B3RQ31 744
type: UnificationXref
id: B3RQ31
db: uniprot

uniprot P63259 314
type: UnificationXref
id: P63259
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Op18_stathmin-RIGHT__Op18_stathmin-_r40
controller: PAK

Ras homolog family member C
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot A0A2I3S4I6 2
organism: Pan troglodytes

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot O88643 476
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r33 933
type: Stoichiometry
physical entity: PAK
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F6W3Y0 465
organism: Xenopus tropicalis

uniprot P09244 800
type: UnificationXref
id: P09244
db: uniprot

uniprot G2HG81 114
type: UnificationXref
id: G2HG81
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot F7ALP1 263
organism: Monodelphis domestica

uniprot P70335 508
type: UnificationXref
id: P70335
db: uniprot

LIM domain kinase 1
type: ProteinReference
xref: uniprot A0A2I3TTQ0 707
organism: Pan troglodytes

Tubulin beta chain
type: ProteinReference
xref: uniprot A0A0R4IXC8 724
xref: PTHR11588:SF88
organism: Danio rerio

PTHR45615:SF11
type: RelationshipXref
id: PTHR45615:SF11
db: PANTHER Family
relationship type: By Homology

uniprot F7A567 420
type: UnificationXref
id: F7A567
db: uniprot

uniprot B3S5E4 214
type: UnificationXref
id: B3S5E4
db: uniprot

uniprot O60879 82
type: UnificationXref
id: O60879
db: uniprot

PARTICIPANT STOICHIOMETRY r33 932
type: Stoichiometry
physical entity: PAK
stoichiometric coefficient: 1.0

uniprot Q8WYL5 74
type: UnificationXref
id: Q8WYL5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Actin-_Complex__Profilin_Actin_-RIGHT__Profilin-_Complex__Actin_Actin_-_r23
controller: Complex (N-WASP/ARP2/ 3)

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 50

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q9TU25 706
xref: PTHR24072:SF169
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E1BA03 454
organism: Bos taurus

uniprot Q2HJ81 829
type: UnificationXref
id: Q2HJ81
db: uniprot

uniprot Q8T8M2 561
type: UnificationXref
id: Q8T8M2
db: uniprot

Rac
type: ProteinReference
xref: P00523
standard name: Ras-related C3 Botulinum toxin substrate 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Rac
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Rac-like GTP-binding protein 6
member entity reference: Ras-related protein Rac2
member entity reference: Rac family small GTPase 3
member entity reference: GTPase cRac1A
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Ras-related protein rac-2
member entity reference: Uncharacterized protein
member entity reference: Uncharacterized protein racE
member entity reference: Ras-related protein Rac1
member entity reference: Rho family GTPase
member entity reference: Rac family small GTPase 1b
member entity reference: Rho-related protein rac1B
member entity reference: Rho-related protein racB
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Rop-family small GTPase
member entity reference: Rac-like GTP-binding protein 5
member entity reference: Rac family small GTPase 1
member entity reference: Uncharacterized protein rac1A
member entity reference: Rac family small GTPase 3a
member entity reference: Rac family small GTPase 2
member entity reference: Rho-related protein racA
member entity reference: Rac family small GTPase 3b
member entity reference: Rac family small GTPase 1a
member entity reference: Rho-related protein racE

uniprot F6UA54 257
type: UnificationXref
id: F6UA54
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot Q9Y7J4 172
organism: Schizosaccharomyces pombe

uniprot P63269 319
type: UnificationXref
id: P63269
db: uniprot

Actin-1
type: ProteinReference
xref: uniprot Q8I4X0 370
xref: PTHR11937:SF387
organism: Plasmodium falciparum

Ras-like GTP-binding protein Rho1
type: ProteinReference
xref: PTHR24072:SF168
xref: uniprot P48148 32
organism: Drosophila melanogaster

uniprot H2QP14 474
type: UnificationXref
id: H2QP14
db: uniprot

Actin-1
type: ProteinReference
xref: PTHR11937:SF469
xref: uniprot Q10DV7 338
organism: Oryza sativa

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF112
xref: uniprot H2QKN9 783
organism: Pan troglodytes

uniprot E2RE16 458
type: UnificationXref
id: E2RE16
db: uniprot

Tubulin beta-3 chain
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot Q13509 825
organism: Homo sapiens

uniprot P0C540 285
type: UnificationXref
id: P0C540
db: uniprot

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: uniprot Q9CVB6 163
xref: PTHR12058:SF0
organism: Mus musculus

uniprot P13542 644
type: UnificationXref
id: P13542
db: uniprot

ARP2 3 s47 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ARP2/3
stoichiometric coefficient: 1.0

uniprot Q9XWV3 171
type: UnificationXref
id: Q9XWV3
db: uniprot

uniprot P07274 543
type: UnificationXref
id: P07274
db: uniprot

uniprot F1P476 245
type: UnificationXref
id: F1P476
db: uniprot

uniprot P68032 321
type: UnificationXref
id: P68032
db: uniprot

uniprot A0A3P6PCS5 87
type: UnificationXref
id: A0A3P6PCS5
db: uniprot

uniprot E3K4I1 236
type: UnificationXref
id: E3K4I1
db: uniprot

Cofilin 2
type: ProteinReference
xref: uniprot F6PGG2 52
organism: Ornithorhynchus anatinus

uniprot A0A1D5NUE9 569
type: UnificationXref
id: A0A1D5NUE9
db: uniprot

uniprot P10587 636
type: UnificationXref
id: P10587
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF310
xref: uniprot E9HEX5 759
organism: Daphnia pulex

Cofilin-1
type: ProteinReference
xref: uniprot Q6NX11 66
organism: Xenopus tropicalis

uniprot Q92888 497
type: UnificationXref
id: Q92888
db: uniprot

Myosin, heavy polypeptide 13, skeletal muscle
type: ProteinReference
xref: PTHR45615:SF44
xref: uniprot B1AR69 584
organism: Mus musculus

uniprot P10989 292
type: UnificationXref
id: P10989
db: uniprot

uniprot O88643 476
type: UnificationXref
id: O88643
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot W4XHC0 876
organism: Strongylocentrotus purpuratus

Protein phosphatase Slingshot homolog 2
type: ProteinReference
xref: uniprot Q5SW75 70
organism: Mus musculus

Cofilin-2
type: ProteinReference
xref: uniprot Q148F1 64
organism: Bos taurus

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot Q01112 427
xref: PTHR24072:SF192
organism: Schizosaccharomyces pombe

Profilin
type: ProteinReference
xref: uniprot Q5A786 559
organism: Candida albicans

ncbitaxon 10090 40
type: UnificationXref
id: 10090
db: ncbitaxon

ARP2/3
type: ProteinReference
xref: P00511
standard name: Actin related protein 2/3 complex
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Actin related protein 2/3 complex Synonym: Synonym not specified Accession: P00511
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.ARP2/3
member entity reference: Actin-related protein 2/3 complex subunit 4
member entity reference: Actin-related protein 2/3 complex subunit 2
member entity reference: Arp2/3 complex 34 kDa subunit
member entity reference: Actin-related protein 2/3 complex subunit
member entity reference: Actin-related protein 2/3 complex subunit 3
member entity reference: Actin-related protein 2/3 complex subunit 1B
member entity reference: Actin-related protein 2/3 complex subunit 5
member entity reference: Actin-related protein 2/3 complex subunit 1
member entity reference: Actin-related protein 2/3 complex subunit 1A
member entity reference: Probable actin-related protein 2/3 complex subunit 3
member entity reference: Uncharacterized protein (Fragment)
member entity reference: Probable actin-related protein 2/3 complex subunit 4

Puccinia graminis
type: BioSource
xref: ncbitaxon 418459 237

Profilin-A
type: ProteinReference
xref: uniprot Q9FUD1 566
organism: Oryza sativa

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot A7RRG4 88
xref: PTHR22629:SF0
organism: Nematostella vectensis

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P90623 334
organism: Trichomonas vaginalis

uniprot P20689 408
type: UnificationXref
id: P20689
db: uniprot

uniprot Q05144 694
type: UnificationXref
id: Q05144
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot A8XSM9 90
organism: Caenorhabditis briggsae

uniprot Q6DIV8 355
type: UnificationXref
id: Q6DIV8
db: uniprot

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 195

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot F7FPY5 112
xref: PTHR22629:SF0
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LVZ9 577
xref: PTHR45615:SF35
organism: Bos taurus

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF1
xref: uniprot B2GV73 92
organism: Rattus norvegicus

Tubulin beta-1 chain
type: ProteinReference
xref: uniprot P12456 806
xref: PTHR11588:SF293
organism: Caenorhabditis elegans

uniprot Q09914 34
type: UnificationXref
id: Q09914
db: uniprot

Actin-10
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot Q54GX7 342
organism: Dictyostelium discoideum

uniprot P09652 801
type: UnificationXref
id: P09652
db: uniprot

ncbitaxon 284812 35
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot P20359 295
type: UnificationXref
id: P20359
db: uniprot

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: uniprot Q9SJW6 166
xref: PTHR10709:SF2
organism: Arabidopsis thaliana

Rho GTPase-activating protein 1
type: ProteinReference
xref: uniprot Q5FWK3 529
xref: PTHR45808:SF6
organism: Mus musculus

uniprot Q29RC5 696
type: UnificationXref
id: Q29RC5
db: uniprot

uniprot F6T2V7 536
type: UnificationXref
id: F6T2V7
db: uniprot

STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r33
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 932
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 933
left: PAK
interaction type: STATE_TRANSITION
right: PAK

uniprot Q6P5M9 851
type: UnificationXref
id: Q6P5M9
db: uniprot

uniprot Q6P9T8 852
type: UnificationXref
id: Q6P9T8
db: uniprot

Major actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P07830 284
organism: Dictyostelium discoideum

uniprot H2RBJ1 117
type: UnificationXref
id: H2RBJ1
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF20
xref: uniprot E2REH3 459
organism: Canis lupus familiaris

uniprot A0A1D5Q7K7 175
type: UnificationXref
id: A0A1D5Q7K7
db: uniprot

GDP s16 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Myosin heavy chain 10
type: ProteinReference
xref: uniprot F7E4E2 618
xref: PTHR45615:SF24
organism: Monodelphis domestica

Tubulin beta chain
type: ProteinReference
xref: uniprot F1QKY8 762
xref: PTHR11588:SF55
organism: Danio rerio

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot P15153 685
xref: PTHR24072:SF169
organism: Homo sapiens

uniprot P35579 645
type: UnificationXref
id: P35579
db: uniprot

uniprot C3XYD3 224
type: UnificationXref
id: C3XYD3
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 13

Uncharacterized protein
type: ProteinReference
xref: uniprot F6X673 711
organism: Monodelphis domestica

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 38

Profilin-3
type: ProteinReference
xref: uniprot Q32PB1 555
organism: Bos taurus

Actin-3
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot P07829 283
organism: Dictyostelium discoideum

Actin-18
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot P07828 282
organism: Dictyostelium discoideum

Pristionchus pacificus
type: BioSource
xref: ncbitaxon 54126 179

uniprot Q5XIS1 71
type: UnificationXref
id: Q5XIS1
db: uniprot

uniprot F6ZIC3 616
type: UnificationXref
id: F6ZIC3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GL73 270
xref: PTHR11937:SF176
organism: Monodelphis domestica

uniprot F0Z796 242
type: UnificationXref
id: F0Z796
db: uniprot

uniprot F7HNC0 79
type: UnificationXref
id: F7HNC0
db: uniprot

uniprot Q10AZ4 337
type: UnificationXref
id: Q10AZ4
db: uniprot

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: uniprot F7F4W9 269
xref: PTHR11937:SF201
organism: Ornithorhynchus anatinus

uniprot O96623 129
type: UnificationXref
id: O96623
db: uniprot

uniprot Q5SX40 656
type: UnificationXref
id: Q5SX40
db: uniprot

uniprot E9FWY0 757
type: UnificationXref
id: E9FWY0
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7SCN8 189
organism: Nematostella vectensis

uniprot Q52WY2 430
type: UnificationXref
id: Q52WY2
db: uniprot

uniprot F6W3Y0 465
type: UnificationXref
id: F6W3Y0
db: uniprot

Profilin
type: ProteinReference
xref: uniprot Q94KS3 562
organism: Chlamydomonas reinhardtii

uniprot Q9CPW4 162
type: UnificationXref
id: Q9CPW4
db: uniprot

uniprot H2Q1R1 625
type: UnificationXref
id: H2Q1R1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__GDP_Cdc42_-RIGHT__Complex__Cdc42_GTP_-_r20
controller: Rho GEFs

uniprot F2Z4N0 248
type: UnificationXref
id: F2Z4N0
db: uniprot

Profilin-1
type: ProteinReference
xref: uniprot Q9XW16 568
organism: Caenorhabditis elegans

uniprot A0A2I3RXX2 573
type: UnificationXref
id: A0A2I3RXX2
db: uniprot

Myosin-7
type: ProteinReference
xref: PTHR45615:SF1
xref: uniprot P12883 640
organism: Homo sapiens

uniprot Q6URW6 660
type: UnificationXref
id: Q6URW6
db: uniprot

GTP-binding protein
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot O93468 26
organism: Gallus gallus

Myosin-1
type: ProteinReference
xref: PTHR45615:SF3
xref: uniprot P12882 639
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC6 221
xref: PTHR11937:SF468
organism: Branchiostoma floridae

ncbitaxon 39947 185
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q8VCR8 413
type: UnificationXref
id: Q8VCR8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC5 220
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC8 223
xref: PTHR11937:SF468
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC7 222
xref: PTHR11937:SF468
organism: Branchiostoma floridae

uniprot A0A2I3TTQ0 707
type: UnificationXref
id: A0A2I3TTQ0
db: uniprot

uniprot P53494 301
type: UnificationXref
id: P53494
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC2 217
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYC4 219
xref: PTHR11937:SF468
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3XYC3 218
organism: Branchiostoma floridae

Tubulin beta-4 chain
type: ProteinReference
xref: uniprot P45960 815
xref: PTHR11588:SF280
organism: Oryza sativa

Actin, alpha 1, skeletal muscle
type: ProteinReference
xref: uniprot Q6DIV8 355
xref: PTHR11937:SF193
organism: Xenopus tropicalis

P00525
type: UnificationXref
id: P00525
db: PANTHER Pathway Component

P00526
type: UnificationXref
id: P00526
db: PANTHER Pathway Component

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1M0G8 449
xref: PTHR48015:SF22
organism: Bos taurus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF306
xref: uniprot Q6TYR8 857
organism: Physcomitrella patens

P00523
type: UnificationXref
id: P00523
db: PANTHER Pathway Component

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF306
xref: uniprot Q6TYR7 856
organism: Physcomitrella patens

P00524
type: UnificationXref
id: P00524
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot A0A3Q1LSY0 448
organism: Bos taurus

P00521
type: UnificationXref
id: P00521
db: PANTHER Pathway Component

Rho-associated protein kinase 1
type: ProteinReference
xref: uniprot Q13464 511
xref: PTHR22988:SF33
organism: Homo sapiens

P00522
type: UnificationXref
id: P00522
db: PANTHER Pathway Component

uniprot P29516 808
type: UnificationXref
id: P29516
db: uniprot

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 348

Uncharacterized protein
type: ProteinReference
xref: PTHR45808:SF6
xref: uniprot F6RWK1 520
organism: Bos taurus

Complex (GDP/Rac)
type: Complex
component stoichiometry: GDP s16 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Rac s18 sa8 STOICHIOMETRY ID COMPLEX
component: Rac
component: GDP
feature: COMPLEX BINDING FEATURE s22 a33 914
feature: COMPLEX BINDING FEATURE s22 a33 912

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF306
xref: uniprot Q6TYR6 855
organism: Physcomitrella patens

Tubulin beta chain
type: ProteinReference
xref: uniprot Q6TYR5 854
xref: PTHR11588:SF306
organism: Physcomitrella patens

uniprot F0ZI20 760
type: UnificationXref
id: F0ZI20
db: uniprot

Tubulin beta-4A chain
type: ProteinReference
xref: uniprot Q9D6F9 871
xref: PTHR11588:SF253
organism: Mus musculus

uniprot O15145 122
type: UnificationXref
id: O15145
db: uniprot

uniprot Q9WV32 170
type: UnificationXref
id: Q9WV32
db: uniprot

Myosin
type: ProteinReference
xref: P00522
standard name: Myosin light chain
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Myosin light chain Synonym: Synonym not specified Accession: P00522
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Myosin
member entity reference: Myosin-10
member entity reference: Myosin-4
member entity reference: Myosin-9
member entity reference: Myosin-7B
member entity reference: Myosin-14
member entity reference: Uncharacterized protein
member entity reference: Myosin-2
member entity reference: Myosin-11
member entity reference: Myosin-6
member entity reference: Myosin-IIIa
member entity reference: Myosin heavy chain 2
member entity reference: Myosin heavy chain 7B
member entity reference: Myosin, heavy chain b
member entity reference: Myosin-13
member entity reference: MYH4 isoform 1
member entity reference: Myosin-7
member entity reference: Myosin heavy chain 11
member entity reference: Myosin heavy chain 14
member entity reference: Myosin heavy chain 13
member entity reference: Myosin heavy chain 4
member entity reference: MYH10 isoform 1
member entity reference: Myosin-1
member entity reference: MYH9 isoform 1
member entity reference: Myosin, heavy polypeptide 2, fast muscle-specific
member entity reference: Myosin-8
member entity reference: MCG140437, isoform CRA_d
member entity reference: Myosin, heavy chain 10, non-muscle
member entity reference: Myosin, heavy chain 9, non-muscle
member entity reference: Myosin-3
member entity reference: MYO3A isoform 1
member entity reference: Myosin heavy chain 10
member entity reference: Myosin heavy chain, non-muscle
member entity reference: Myosin, heavy polypeptide 1.3, skeletal muscle
member entity reference: Neither inactivation nor afterpotential protein C
member entity reference: Developmental myosin heavy chain embryonic
member entity reference: Myosin, heavy chain a
member entity reference: MYH14 isoform 6
member entity reference: Myosin IIIA
member entity reference: Myosin-IIIb

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: PTHR22629:SF0
xref: uniprot F0Z6V2 99
organism: Dictyostelium purpureum

Myosin heavy chain 11
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot A0A2I3RHK4 571
organism: Pan troglodytes

Tubulin beta-2 chain
type: ProteinReference
xref: PTHR11588:SF375
xref: uniprot P32882 811
organism: Gallus gallus

uniprot C3XYC6 221
type: UnificationXref
id: C3XYC6
db: uniprot

uniprot E1BP87 590
type: UnificationXref
id: E1BP87
db: uniprot

Cofilin-2
type: ProteinReference
xref: uniprot P45591 60
organism: Mus musculus

Actin-related protein 2/3 complex subunit 1
type: ProteinReference
xref: uniprot P78774 140
xref: PTHR10709:SF2
organism: Schizosaccharomyces pombe

uniprot Q076A4 649
type: UnificationXref
id: Q076A4
db: uniprot

Actin-related protein 2/3 complex subunit 4
type: ProteinReference
xref: uniprot Q148J6 144
xref: PTHR22629:SF0
organism: Bos taurus

Proline-rich protein 5
type: ProteinReference
xref: uniprot Q812A5 530
organism: Mus musculus

Cofilin-1
type: ProteinReference
xref: uniprot P45592 61
organism: Rattus norvegicus

Actin-2
type: ProteinReference
xref: PTHR11937:SF430
xref: uniprot Q96292 374
organism: Arabidopsis thaliana

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q75BP6 858
organism: Ashbya gossypii

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF2
xref: uniprot F6ZHU6 615
organism: Macaca mulatta

uniprot Q874R1 41
type: UnificationXref
id: Q874R1
db: uniprot

Actin 1
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q6TYS2 361
organism: Physcomitrella patens

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 95

uniprot A7SEB1 191
type: UnificationXref
id: A7SEB1
db: uniprot

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot Q5ZMQ2 351
organism: Gallus gallus

uniprot B7PA92 745
type: UnificationXref
id: B7PA92
db: uniprot

uniprot F2Z4N7 249
type: UnificationXref
id: F2Z4N7
db: uniprot

uniprot Q9UKX3 672
type: UnificationXref
id: Q9UKX3
db: uniprot

Actin
type: ProteinReference
xref: uniprot A8JAV1 194
xref: PTHR11937:SF387
organism: Chlamydomonas reinhardtii

Uncharacterized protein
type: ProteinReference
xref: PTHR45808:SF6
xref: uniprot F6T0E0 521
organism: Macaca mulatta

ARP2/3
type: Protein
entity reference: ARP2/3
comment: SPECIES_TYPE=PROTEIN

P00509
type: UnificationXref
id: P00509
db: PANTHER Pathway Component

uniprot P53497 302
type: UnificationXref
id: P53497
db: uniprot

P00507
type: UnificationXref
id: P00507
db: PANTHER Pathway Component

P00508
type: UnificationXref
id: P00508
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYD4 225
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: uniprot C3XYD3 224
organism: Branchiostoma floridae

Tubulin beta chain
type: ProteinReference
xref: uniprot W4XKG7 877
xref: PTHR11588:SF314
organism: Strongylocentrotus purpuratus

Tubulin beta-2 chain
type: ProteinReference
xref: PTHR11588:SF376
xref: uniprot P52275 816
organism: Caenorhabditis elegans

ncbitaxon 5759 211
type: UnificationXref
id: 5759
db: ncbitaxon

N-WASP
type: ProteinReference
xref: P00525
standard name: Wiskott-Aldrich syndrome protein family member 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Wiskott-Aldrich syndrome protein family member 1 Synonym: SCAR,WASF1,WASP family, verprolin homology domain-containing protein,WAVE Accession: P00525
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.N-WASP
member entity reference: Neural Wiskott-Aldrich syndrome protein
member entity reference: Wiskott-Aldrich syndrome like
member entity reference: Uncharacterized protein
member entity reference: WASL isoform 1

uniprot P78711 330
type: UnificationXref
id: P78711
db: uniprot

uniprot Q6B856 846
type: UnificationXref
id: Q6B856
db: uniprot

P00520
type: UnificationXref
id: P00520
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot F0Z796 242
xref: PTHR11937:SF421
organism: Dictyostelium purpureum

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r33
controller: Complex (Cdc42/GTP)

P00510
type: UnificationXref
id: P00510
db: PANTHER Pathway Component

P00511
type: UnificationXref
id: P00511
db: PANTHER Pathway Component

P00512
type: UnificationXref
id: P00512
db: PANTHER Pathway Component

P00513
type: UnificationXref
id: P00513
db: PANTHER Pathway Component

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 177

P00514
type: UnificationXref
id: P00514
db: PANTHER Pathway Component

P00515
type: UnificationXref
id: P00515
db: PANTHER Pathway Component

uniprot A0A0R4IXC8 724
type: UnificationXref
id: A0A0R4IXC8
db: uniprot

P00516
type: UnificationXref
id: P00516
db: PANTHER Pathway Component

Tubulin beta-8 chain
type: ProteinReference
xref: uniprot Q3ZCM7 835
xref: PTHR11588:SF55
organism: Homo sapiens

P00517
type: UnificationXref
id: P00517
db: PANTHER Pathway Component

GTP-binding protein RHO1
type: ProteinReference
xref: uniprot Q9HF54 46
xref: PTHR24072:SF168
organism: Ashbya gossypii

P00518
type: UnificationXref
id: P00518
db: PANTHER Pathway Component

P00519
type: UnificationXref
id: P00519
db: PANTHER Pathway Component

uniprot P62736 310
type: UnificationXref
id: P62736
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F7B0P2 772
xref: PTHR11588:SF88
organism: Ornithorhynchus anatinus

uniprot Q9H1R3 414
type: UnificationXref
id: Q9H1R3
db: uniprot

PTHR45615:SF40
type: RelationshipXref
id: PTHR45615:SF40
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF43
type: RelationshipXref
id: PTHR45615:SF43
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF44
type: RelationshipXref
id: PTHR45615:SF44
db: PANTHER Family
relationship type: By Homology

Cell division control protein 42
type: ProteinReference
xref: uniprot Q9HF56 435
xref: PTHR24072:SF192
organism: Ashbya gossypii

uniprot P60710 307
type: UnificationXref
id: P60710
db: uniprot

uniprot Q922F4 867
type: UnificationXref
id: Q922F4
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot F1NYB1 761
organism: Gallus gallus

PTHR45615:SF39
type: RelationshipXref
id: PTHR45615:SF39
db: PANTHER Family
relationship type: By Homology

uniprot Q27991 653
type: UnificationXref
id: Q27991
db: uniprot

uniprot P62962 551
type: UnificationXref
id: P62962
db: uniprot

uniprot A7S9Y5 10
type: UnificationXref
id: A7S9Y5
db: uniprot

Protein diaphanous homolog 3
type: ProteinReference
xref: uniprot F1LVW7 76
organism: Rattus norvegicus

uniprot P50552 442
type: UnificationXref
id: P50552
db: uniprot

uniprot F1PYF1 18
type: UnificationXref
id: F1PYF1
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot A8XX81 740
xref: PTHR11588:SF376
organism: Caenorhabditis briggsae

ncbitaxon 227321 43
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot F6Z9H7 467
type: UnificationXref
id: F6Z9H7
db: uniprot

mDia
type: ProteinReference
xref: P00510
standard name: Mammalian diaphanous
comment: ENTITY_REFERENCE_NOTES=Long Name: Mammalian diaphanous Synonym: DIAPH Accession: P00510
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.mDia
member entity reference: Protein diaphanous homolog 3
member entity reference: Diaphanous related formin 2
member entity reference: Uncharacterized protein
member entity reference: Protein diaphanous homolog 2
member entity reference: Protein diaphanous homolog 1

uniprot Q9CWF2 870
type: UnificationXref
id: Q9CWF2
db: uniprot

Myosin-7
type: ProteinReference
xref: uniprot Q91Z83 666
xref: PTHR45615:SF1
organism: Mus musculus

Complex (Rho/GTP)
type: Complex
component stoichiometry: Rho s3 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: GTP s9 sa4 STOICHIOMETRY ID COMPLEX
component: Rho
component: GTP
feature: COMPLEX BINDING FEATURE s19 a28 900
feature: COMPLEX BINDING FEATURE s19 a28 898

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A7EH60 732
organism: Sclerotinia sclerotiorum

ACTA1 isoform 1
type: ProteinReference
xref: PTHR11937:SF193
xref: uniprot H2Q1A9 273
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RJA0 460
xref: PTHR48015:SF22
organism: Canis lupus familiaris

STATE_TRANSITION_LEFT__Complex__Actin_Actin_-RIGHT__Actin-_r29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 960
participant stoichiometry: PARTICIPANT STOICHIOMETRY r29 961
left: Complex (Actin/Actin)
interaction type: STATE_TRANSITION
right: Actin

uniprot P78774 140
type: UnificationXref
id: P78774
db: uniprot

Profilin-1
type: ProteinReference
xref: uniprot P26199 546
organism: Dictyostelium discoideum

PTHR45615:SF48
type: RelationshipXref
id: PTHR45615:SF48
db: PANTHER Family
relationship type: By Homology

uniprot Q5SW75 70
type: UnificationXref
id: Q5SW75
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot A0A2I3TC58 727
xref: PTHR11588:SF55
organism: Pan troglodytes

Myosin light chain kinase
type: ProteinReference
xref: PTHR47633:SF1
xref: uniprot A0A2I3TJW3 401
organism: Pan troglodytes

uniprot A4FV20 6
type: UnificationXref
id: A4FV20
db: uniprot

PTHR45615:SF23
type: RelationshipXref
id: PTHR45615:SF23
db: PANTHER Family
relationship type: By Homology

uniprot F6WYK8 769
type: UnificationXref
id: F6WYK8
db: uniprot

PTHR45615:SF24
type: RelationshipXref
id: PTHR45615:SF24
db: PANTHER Family
relationship type: By Homology

Tubulin beta-2A chain
type: ProteinReference
xref: PTHR11588:SF100
xref: uniprot Q13885 826
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CIV4 264
xref: PTHR11937:SF150
organism: Ornithorhynchus anatinus

uniprot Q562R1 345
type: UnificationXref
id: Q562R1
db: uniprot

uniprot G5EF01 782
type: UnificationXref
id: G5EF01
db: uniprot

uniprot Q7Z406 661
type: UnificationXref
id: Q7Z406
db: uniprot

Ena/VASP
type: ProteinReference
xref: P00516
standard name: Enabled/vasodialator stimulated phosphoprotein
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Ena/VASP
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Enabled/vasodialator stimulated phosphoprotein Synonym: Synonym not specified Accession: P00516
member entity reference: Vasodilator-stimulated phosphoprotein
member entity reference: ENAH, actin regulator
member entity reference: Protein enabled homolog
member entity reference: Ena/VASP-like protein
member entity reference: Uncharacterized protein

ncbitaxon 284811 47
type: UnificationXref
id: 284811
db: ncbitaxon

uniprot C4M5Z7 678
type: UnificationXref
id: C4M5Z7
db: uniprot

PTHR45615:SF16
type: RelationshipXref
id: PTHR45615:SF16
db: PANTHER Family
relationship type: By Homology

Myosin IIIA
type: ProteinReference
xref: PTHR46256:SF4
xref: uniprot D3ZZK7 589
organism: Rattus norvegicus

Myosin heavy chain 10
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot F1PVV7 601
organism: Canis lupus familiaris

PTHR45615:SF35
type: RelationshipXref
id: PTHR45615:SF35
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Cofilin-RIGHT__Cofilin-_r36
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 927
participant stoichiometry: PARTICIPANT STOICHIOMETRY r36 926
left: Cofilin
interaction type: STATE_TRANSITION
right: Cofilin

uniprot Q7YTV5 366
type: UnificationXref
id: Q7YTV5
db: uniprot

STATE_TRANSITION_LEFT__Cofilin-RIGHT__Cofilin-_r34
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 930
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 931
left: Cofilin
interaction type: STATE_TRANSITION
right: Cofilin

PTHR45615:SF31
type: RelationshipXref
id: PTHR45615:SF31
db: PANTHER Family
relationship type: By Homology

uniprot A8XSF1 739
type: UnificationXref
id: A8XSF1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H1Q7 421
organism: Macaca mulatta

uniprot Q5FVG6 528
type: UnificationXref
id: Q5FVG6
db: uniprot

Myosin Light Chain Kinase related
type: ProteinReference
xref: uniprot Q23260 410
organism: Caenorhabditis elegans

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__Profilin-_Actin-RIGHT__Complex__Profilin_Actin_-_r27
controller: Ena/VASP

Actin 5
type: ProteinReference
xref: uniprot A9TZ58 207
xref: PTHR11937:SF387
organism: Physcomitrella patens

uniprot Q8H7U1 865
type: UnificationXref
id: Q8H7U1
db: uniprot

uniprot Q6EP31 699
type: UnificationXref
id: Q6EP31
db: uniprot

uniprot F7ALP1 263
type: UnificationXref
id: F7ALP1
db: uniprot

uniprot W4YBZ7 880
type: UnificationXref
id: W4YBZ7
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P78711 330
organism: Neurospora crassa

uniprot A0A3S5ZPV2 438
type: UnificationXref
id: A0A3S5ZPV2
db: uniprot

uniprot C3ZHN4 232
type: UnificationXref
id: C3ZHN4
db: uniprot

PTHR45615:SF29
type: RelationshipXref
id: PTHR45615:SF29
db: PANTHER Family
relationship type: By Homology

PTHR45615:SF26
type: RelationshipXref
id: PTHR45615:SF26
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q4QI42 841
organism: Leishmania major

uniprot P08134 30
type: UnificationXref
id: P08134
db: uniprot

uniprot F7G5G3 404
type: UnificationXref
id: F7G5G3
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot E2RMT4 98
xref: PTHR10709:SF10
organism: Canis lupus familiaris

Cdc42 GTPase-activating protein
type: ProteinReference
xref: PTHR45808:SF6
xref: uniprot A4GT58 517
organism: Canis lupus familiaris

Rho GTPase-activating protein 68F
type: ProteinReference
xref: uniprot Q9VTU3 531
organism: Drosophila melanogaster

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot Q7ZUQ0 157
organism: Danio rerio

uniprot F1N2G0 596
type: UnificationXref
id: F1N2G0
db: uniprot

uniprot F7BZM9 108
type: UnificationXref
id: F7BZM9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6QWB7 251
xref: PTHR11937:SF477
organism: Ornithorhynchus anatinus

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot Q92747 161
organism: Homo sapiens

uniprot Q9JM76 164
type: UnificationXref
id: Q9JM76
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot W4YEV4 881
organism: Strongylocentrotus purpuratus

uniprot Q62159 39
type: UnificationXref
id: Q62159
db: uniprot

uniprot C4MB21 533
type: UnificationXref
id: C4MB21
db: uniprot

Putative actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A0A0D1DMT3 173
organism: Ustilago maydis

uniprot F7H2A5 539
type: UnificationXref
id: F7H2A5
db: uniprot

Profilin-1
type: ProteinReference
xref: uniprot P02584 542
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PAK-RIGHT__PAK-_r33
controller: Complex (Rac/GTP)

uniprot F1QUN8 246
type: UnificationXref
id: F1QUN8
db: uniprot

uniprot Q92747 161
type: UnificationXref
id: Q92747
db: uniprot

uniprot A0A0G2K9C0 437
type: UnificationXref
id: A0A0G2K9C0
db: uniprot

Axonal plasticity
type: Pathway

uniprot Q9UKX2 671
type: UnificationXref
id: Q9UKX2
db: uniprot

Actin-42A
type: ProteinReference
xref: uniprot P02572 280
xref: PTHR11937:SF453
organism: Drosophila melanogaster

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF1
xref: uniprot H2RBJ1 117
organism: Pan troglodytes

LIM domain kinase 1
type: ProteinReference
xref: uniprot E2RQT0 709
organism: Canis lupus familiaris

uniprot O15511 123
type: UnificationXref
id: O15511
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7FKL1 470
organism: Macaca mulatta

Actin, larval muscle
type: ProteinReference
xref: uniprot P02574 281
xref: PTHR11937:SF397
organism: Drosophila melanogaster

Rac family small GTPase 1
type: ProteinReference
xref: uniprot Q6GL60 700
xref: PTHR24072:SF105
organism: Xenopus tropicalis

uniprot O08719 440
type: UnificationXref
id: O08719
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot E9GER1 758
organism: Daphnia pulex

PTHR10709:SF2
type: RelationshipXref
id: PTHR10709:SF2
db: PANTHER Family
relationship type: By Homology

Protein CBR-ACT-5
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot A8XS95 199
organism: Caenorhabditis briggsae

Uncharacterized protein rac1A
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot F1A084 681
organism: Dictyostelium purpureum

PTHR23202:SF39
type: RelationshipXref
id: PTHR23202:SF39
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase PAK 4
type: ProteinReference
xref: uniprot Q8BTW9 489
organism: Mus musculus

uniprot P35749 647
type: UnificationXref
id: P35749
db: uniprot

Beta-actin-like protein 2
type: ProteinReference
xref: PTHR11937:SF168
xref: uniprot Q562R1 345
organism: Homo sapiens

uniprot E2REH3 459
type: UnificationXref
id: E2REH3
db: uniprot

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: uniprot Q9WV32 170
xref: PTHR10709:SF10
organism: Mus musculus

Profilin-2
type: ProteinReference
xref: uniprot Q9EPC6 564
organism: Rattus norvegicus

uniprot P61857 817
type: UnificationXref
id: P61857
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot B1N2P0 210
organism: Entamoeba histolytica

Actin-related protein 2/3 complex subunit 1A
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot Q9R0Q6 165
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r29 961
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r29 960
type: Stoichiometry
physical entity: Complex (Actin/Actin)
stoichiometric coefficient: 1.0

uniprot Q40665 836
type: UnificationXref
id: Q40665
db: uniprot

PARTICIPANT STOICHIOMETRY r39 922
type: Stoichiometry
physical entity: Complex (tubulin/tubulin)
stoichiometric coefficient: 1.0

uniprot O96622 127
type: UnificationXref
id: O96622
db: uniprot

PARTICIPANT STOICHIOMETRY r39 923
type: Stoichiometry
physical entity: tubulin
stoichiometric coefficient: 1.0

PTHR11937:SF278
type: RelationshipXref
id: PTHR11937:SF278
db: PANTHER Family
relationship type: By Homology

uniprot Q28BZ0 429
type: UnificationXref
id: Q28BZ0
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 17

uniprot F7FFR0 779
type: UnificationXref
id: F7FFR0
db: uniprot

uniprot A0A2K6I1R2 728
type: UnificationXref
id: A0A2K6I1R2
db: uniprot

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: uniprot Q6GL82 152
xref: PTHR12058:SF0
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF3
xref: uniprot H2QCA0 629
organism: Pan troglodytes

Actin
type: Complex
component stoichiometry: Actin s48 sa15 STOICHIOMETRY ID COMPLEX
component: Actin
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa15 911

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot H2Q960 473
organism: Pan troglodytes

uniprot F1LNF0 591
type: UnificationXref
id: F1LNF0
db: uniprot

uniprot P62999 691
type: UnificationXref
id: P62999
db: uniprot

uniprot Q08E52 479
type: UnificationXref
id: Q08E52
db: uniprot

uniprot A0A2A6CRA8 178
type: UnificationXref
id: A0A2A6CRA8
db: uniprot

PTHR11937:SF248
type: RelationshipXref
id: PTHR11937:SF248
db: PANTHER Family
relationship type: By Homology

uniprot F1MRC2 594
type: UnificationXref
id: F1MRC2
db: uniprot

uniprot H2QS82 784
type: UnificationXref
id: H2QS82
db: uniprot

uniprot F7G117 620
type: UnificationXref
id: F7G117
db: uniprot

uniprot P68034 323
type: UnificationXref
id: P68034
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF88
xref: uniprot E2QYC2 754
organism: Canis lupus familiaris

PTHR11937:SF240
type: RelationshipXref
id: PTHR11937:SF240
db: PANTHER Family
relationship type: By Homology

uniprot E1BHJ0 534
type: UnificationXref
id: E1BHJ0
db: uniprot

Neural Wiskott-Aldrich syndrome protein
type: ProteinReference
xref: uniprot Q95107 723
xref: PTHR23202:SF39
organism: Bos taurus

Rho associated coiled-coil containing protein kinase 2
type: ProteinReference
xref: uniprot F7DDX8 503
organism: Monodelphis domestica

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q4GYY6 838
organism: Trypanosoma brucei

Tubulin beta-2 chain
type: ProteinReference
xref: PTHR11588:SF325
xref: uniprot Q56YW9 844
organism: Arabidopsis thaliana

Tubulin beta chain
type: ProteinReference
xref: uniprot H3FHL1 790
xref: PTHR11588:SF279
organism: Pristionchus pacificus

Tubulin beta chain
type: ProteinReference
xref: uniprot H3FHL0 789
xref: PTHR11588:SF293
organism: Pristionchus pacificus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF293
xref: uniprot H3FHK9 788
organism: Pristionchus pacificus

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot F7A567 420
organism: Monodelphis domestica

uniprot P12883 640
type: UnificationXref
id: P12883
db: uniprot

Cdc42 homolog
type: ProteinReference
xref: PTHR24072:SF192
xref: uniprot Q17031 428
organism: Anopheles gambiae

uniprot Q8CIN4 491
type: UnificationXref
id: Q8CIN4
db: uniprot

uniprot Q148J6 144
type: UnificationXref
id: Q148J6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HNC0 79
organism: Macaca mulatta

ncbitaxon 36329 371
type: UnificationXref
id: 36329
db: ncbitaxon

ncbitaxon 44689 128
type: UnificationXref
id: 44689
db: ncbitaxon

ncbitaxon 9598 3
type: UnificationXref
id: 9598
db: ncbitaxon

LIM domain kinase 1
type: ProteinReference
xref: uniprot Q8QFP8 715
organism: Gallus gallus

uniprot C3YPV2 94
type: UnificationXref
id: C3YPV2
db: uniprot

MYH14 isoform 6
type: ProteinReference
xref: uniprot A0A2I3RKA2 572
organism: Pan troglodytes

uniprot Q90694 433
type: UnificationXref
id: Q90694
db: uniprot

Profilin
type: ProteinReference
xref: uniprot H2QBZ3 540
organism: Pan troglodytes

uniprot Q23260 410
type: UnificationXref
id: Q23260
db: uniprot

PARTICIPANT STOICHIOMETRY r19 936
type: Stoichiometry
physical entity: Complex (GDP/Rac)
stoichiometric coefficient: 1.0

PTHR24072:SF17
type: RelationshipXref
id: PTHR24072:SF17
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r19 937
type: Stoichiometry
physical entity: Complex (Rac/GTP)
stoichiometric coefficient: 1.0

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF61
xref: uniprot P07437 797
organism: Homo sapiens

uniprot A2EM81 731
type: UnificationXref
id: A2EM81
db: uniprot

uniprot Q0IPW3 336
type: UnificationXref
id: Q0IPW3
db: uniprot

uniprot H3FHL1 790
type: UnificationXref
id: H3FHL1
db: uniprot

ncbitaxon 5664 377
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot F6TYN8 768
type: UnificationXref
id: F6TYN8
db: uniprot

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot P35465 478
xref: PTHR48015:SF20
organism: Rattus norvegicus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot C3Y2F5 750
organism: Branchiostoma floridae

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF35
xref: uniprot F6ZIC3 616
organism: Macaca mulatta

S16 Op18 stathmin s39 a59 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S16
feature location: S16 Op18 stathmin s39 a59 rs1 S16
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_NAME=S16
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=2.677945044588987

Myosin-6
type: ProteinReference
xref: uniprot P02563 633
xref: PTHR45615:SF11
organism: Rattus norvegicus

Myosin-7
type: ProteinReference
xref: PTHR45615:SF1
xref: uniprot P02564 634
organism: Rattus norvegicus

Myosin-1B
type: ProteinReference
xref: uniprot P02565 635
xref: PTHR45615:SF48
organism: Gallus gallus

uniprot A7S027 733
type: UnificationXref
id: A7S027
db: uniprot

Myosin heavy chain 13
type: ProteinReference
xref: uniprot F1MZX6 595
organism: Bos taurus

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot O97182 133
xref: PTHR10709:SF2
organism: Drosophila melanogaster

uniprot Q4QRB4 843
type: UnificationXref
id: Q4QRB4
db: uniprot

Myosin-10
type: ProteinReference
xref: uniprot Q61879 657
xref: PTHR45615:SF24
organism: Mus musculus

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot Q32MK0 412
type: UnificationXref
id: Q32MK0
db: uniprot

Op18/stathmin
type: ProteinReference
xref: P00513
standard name: Stathmin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Op18/stathmin
comment: ENTITY_REFERENCE_NOTES=Long Name: Stathmin Synonym: LAP18,Leukemia associated phosphoprotein p18,SMN Accession: P00513
member entity reference: Stathmin
member entity reference: Stathmin 4
member entity reference: Stathmin-4
member entity reference: Uncharacterized protein

Myosin light chain kinase 2, skeletal/cardiac muscle
type: ProteinReference
xref: uniprot Q9H1R3 414
xref: PTHR24347:SF373
organism: Homo sapiens

uniprot C3YJC1 676
type: UnificationXref
id: C3YJC1
db: uniprot

uniprot O96013 477
type: UnificationXref
id: O96013
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot P02557 793
organism: Saccharomyces cerevisiae

Tubulin beta-2A chain
type: ProteinReference
xref: PTHR11588:SF100
xref: uniprot Q7TMM9 864
organism: Mus musculus

uniprot P68371 818
type: UnificationXref
id: P68371
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 43

Actin, muscle
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot W4XTP5 380
organism: Strongylocentrotus purpuratus

uniprot F7H998 113
type: UnificationXref
id: F7H998
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F0ZI20 760
xref: PTHR11588:SF306
organism: Dictyostelium purpureum

uniprot Q9FE63 565
type: UnificationXref
id: Q9FE63
db: uniprot

ncbitaxon 5786 100
type: UnificationXref
id: 5786
db: ncbitaxon

Tubulin beta-8 chain
type: ProteinReference
xref: uniprot Q8WP14 866
xref: PTHR11588:SF55
organism: Pan troglodytes

uniprot A0A1D5QVF5 570
type: UnificationXref
id: A0A1D5QVF5
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P62999 691
xref: PTHR24072:SF105
organism: Canis lupus familiaris

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF362
xref: uniprot Q7ZVI7 368
organism: Danio rerio

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot Q6PE34 853
organism: Danio rerio

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TYG6 206
organism: Physcomitrella patens

ncbitaxon 9544 50
type: UnificationXref
id: 9544
db: ncbitaxon

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9TYG3 205
organism: Physcomitrella patens

uniprot Q076A5 650
type: UnificationXref
id: Q076A5
db: uniprot

PARTICIPANT STOICHIOMETRY r45 953
type: Stoichiometry
physical entity: mDia
stoichiometric coefficient: 1.0

MODULATION
type: Control
xref: MODULATION
controlled: Axonal plasticity
controller: tubulin

PARTICIPANT STOICHIOMETRY r45 952
type: Stoichiometry
physical entity: mDia
stoichiometric coefficient: 1.0

uniprot C3YP58 229
type: UnificationXref
id: C3YP58
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot Q6NW90 849
xref: PTHR11588:SF61
organism: Danio rerio

MCG140437, isoform CRA_d
type: ProteinReference
xref: uniprot G3UW82 624
xref: PTHR45615:SF39
organism: Mus musculus

Myosin heavy chain 14
type: ProteinReference
xref: PTHR45615:SF31
xref: uniprot F1LNF0 591
organism: Rattus norvegicus

Ena/VASP-like protein
type: ProteinReference
xref: uniprot P70429 443
organism: Mus musculus

Actin A
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot Q38E94 339
organism: Trypanosoma brucei

Tubulin beta-1 chain
type: ProteinReference
xref: uniprot Q9H4B7 873
xref: PTHR11588:SF112
organism: Homo sapiens

uniprot Q1RMJ6 36
type: UnificationXref
id: Q1RMJ6
db: uniprot

Complex (N-WASP/ARP2/ 3)
type: Complex
component stoichiometry: ARP2 3 s47 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: N WASP s46 sa13 STOICHIOMETRY ID COMPLEX
component: ARP2/3
component: N-WASP
feature: COMPLEX BINDING FEATURE s26 a38 894
feature: COMPLEX BINDING FEATURE s26 a38 892

uniprot Q8C015 490
type: UnificationXref
id: Q8C015
db: uniprot

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot P60766 424
organism: Mus musculus

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot Q9CPW4 162
xref: PTHR12644:SF1
organism: Mus musculus

uniprot C3XYC4 219
type: UnificationXref
id: C3XYC4
db: uniprot

ACTC1 isoform 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot H2Q943 274
organism: Pan troglodytes

ncbitaxon 237631 174
type: UnificationXref
id: 237631
db: ncbitaxon

uniprot A0A0R4IHT4 499
type: UnificationXref
id: A0A0R4IHT4
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 29

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF253
xref: uniprot G2HGK8 781
organism: Pan troglodytes

Actin
type: Protein
entity reference: Actin

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 33

uniprot Q7ZSZ9 704
type: UnificationXref
id: Q7ZSZ9
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A7SJX9 736
organism: Nematostella vectensis

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF1
xref: uniprot F7H998 113
organism: Macaca mulatta

uniprot Q6P640 359
type: UnificationXref
id: Q6P640
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot A9SJR1 743
xref: PTHR11588:SF306
organism: Physcomitrella patens

uniprot P68134 326
type: UnificationXref
id: P68134
db: uniprot

Vasodilator-stimulated phosphoprotein
type: ProteinReference
xref: uniprot P70460 444
xref: PTHR11202:SF12
organism: Mus musculus

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF112
xref: uniprot F6XQ37 770
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot D3ZQ51 452
organism: Rattus norvegicus

uniprot B2RZ72 93
type: UnificationXref
id: B2RZ72
db: uniprot

Actin
type: ProteinReference
xref: uniprot Q9UVF3 378
xref: PTHR11937:SF387
organism: Yarrowia lipolytica

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF414
xref: uniprot F7EU36 267
organism: Monodelphis domestica

STATE_TRANSITION_LEFT__Complex__Rho_GTP_-RIGHT__Complex__GDP_Rho_-_Pi-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 950
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 951
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 949
left: Complex (Rho/GTP)
interaction type: STATE_TRANSITION
right: Pi
right: Complex (GDP/Rho)

Profilin-1
type: ProteinReference
xref: uniprot P62962 551
organism: Mus musculus

Profilin-1
type: ProteinReference
xref: uniprot P62963 552
organism: Rattus norvegicus

uniprot Q18817 827
type: UnificationXref
id: Q18817
db: uniprot

uniprot A7EH60 732
type: UnificationXref
id: A7EH60
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RCG1 718
xref: PTHR23202:SF39
organism: Canis lupus familiaris

uniprot A8XMP5 89
type: UnificationXref
id: A8XMP5
db: uniprot

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 371

uniprot D3ZZK7 589
type: UnificationXref
id: D3ZZK7
db: uniprot

Ena/VASP
type: Protein
entity reference: Ena/VASP
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot W4ZD41 382
xref: PTHR11937:SF446
organism: Strongylocentrotus purpuratus

HETERODIMER_ASSOCIATION_LEFT__Profilin-_Actin-RIGHT__Complex__Profilin_Actin_-_r27
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 964
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 962
participant stoichiometry: PARTICIPANT STOICHIOMETRY r27 963
left: Profilin
left: Actin
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Profilin/Actin)

uniprot E1C3P6 456
type: UnificationXref
id: E1C3P6
db: uniprot

uniprot C3YMF1 752
type: UnificationXref
id: C3YMF1
db: uniprot

Cytoplasmatic actin
type: ProteinReference
xref: uniprot E9HGF5 241
xref: PTHR11937:SF423
organism: Daphnia pulex

uniprot A0JP99 450
type: UnificationXref
id: A0JP99
db: uniprot

Actin alpha 1, skeletal muscle a
type: ProteinReference
xref: PTHR11937:SF416
xref: uniprot F1QUN8 246
organism: Danio rerio

Cell division control protein 42
type: ProteinReference
xref: uniprot P19073 422
xref: PTHR24072:SF192
organism: Saccharomyces cerevisiae

ncbitaxon 284591 379
type: UnificationXref
id: 284591
db: ncbitaxon

uniprot Q62868 513
type: UnificationXref
id: Q62868
db: uniprot

uniprot F7E4E2 618
type: UnificationXref
id: F7E4E2
db: uniprot

GTP-binding protein rho4
type: ProteinReference
xref: uniprot Q874R1 41
organism: Schizosaccharomyces pombe

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot Q5R1X3 350
organism: Pan troglodytes

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot F6U132 105
organism: Monodelphis domestica

Myosin light chain kinase 3
type: ProteinReference
xref: PTHR24347:SF394
xref: uniprot Q32MK0 412
organism: Homo sapiens

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: uniprot O15145 122
xref: PTHR12391:SF1
organism: Homo sapiens

…
type: Stoichiometry
physical entity: Actin
stoichiometric coefficient: 4.0

uniprot A9JRY8 674
type: UnificationXref
id: A9JRY8
db: uniprot

ncbitaxon 9615 19
type: UnificationXref
id: 9615
db: ncbitaxon

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A7S027 733
organism: Nematostella vectensis

ncbitaxon 3055 195
type: UnificationXref
id: 3055
db: ncbitaxon

Protein phosphatase Slingshot
type: ProteinReference
xref: uniprot Q6NN85 72
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot F6UA54 257
organism: Macaca mulatta

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 67

Tubulin beta-3 chain
type: ProteinReference
xref: uniprot P08841 798
xref: PTHR11588:SF273
organism: Drosophila melanogaster

uniprot F1LVW7 76
type: UnificationXref
id: F1LVW7
db: uniprot

Actin-related protein 2/3 complex subunit 1B
type: ProteinReference
xref: uniprot O15143 120
xref: PTHR10709:SF10
organism: Homo sapiens

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: PTHR12058:SF0
xref: uniprot O15144 121
organism: Homo sapiens

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot F6PVY4 103
organism: Macaca mulatta

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q1RMJ6 36
organism: Bos taurus

Cell division control protein 42 homolog
type: ProteinReference
xref: PTHR24072:SF136
xref: uniprot Q8CFN2 432
organism: Rattus norvegicus

PTHR11588:SF100
type: RelationshipXref
id: PTHR11588:SF100
db: PANTHER Family
relationship type: By Homology

uniprot H3FHL0 789
type: UnificationXref
id: H3FHL0
db: uniprot

uniprot Q91YD9 722
type: UnificationXref
id: Q91YD9
db: uniprot

ncbitaxon 7719 177
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot Q7PXZ8 365
type: UnificationXref
id: Q7PXZ8
db: uniprot

Cdc42 s45 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Cdc42
stoichiometric coefficient: 1.0

MYH3 protein
type: ProteinReference
xref: PTHR45615:SF6
xref: uniprot A6QPA6 582
organism: Bos taurus

uniprot Q9I8V1 375
type: UnificationXref
id: Q9I8V1
db: uniprot

Rho-related GTP-binding protein RhoC
type: ProteinReference
xref: PTHR24072:SF100
xref: uniprot Q62159 39
organism: Mus musculus

Myosin-4
type: ProteinReference
xref: uniprot Q5SX39 655
xref: PTHR45615:SF2
organism: Mus musculus

MYH4 isoform 1
type: ProteinReference
xref: PTHR45615:SF2
xref: uniprot H2R9J3 631
organism: Pan troglodytes

Tubulin beta chain
type: ProteinReference
xref: uniprot A0A1D5QYU3 726
xref: PTHR11588:SF247
organism: Macaca mulatta

uniprot A0A2I3RZA9 75
type: UnificationXref
id: A0A2I3RZA9
db: uniprot

Myosin-14
type: ProteinReference
xref: PTHR45615:SF31
xref: uniprot Q6URW6 660
organism: Mus musculus

uniprot F6RFW8 253
type: UnificationXref
id: F6RFW8
db: uniprot

Myosin-1
type: ProteinReference
xref: PTHR45615:SF3
xref: uniprot Q5SX40 656
organism: Mus musculus

Serine/threonine-protein kinase PAK 3
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot Q61036 485
organism: Mus musculus

STATE_TRANSITION_LEFT__Actin-_Complex__Profilin_Actin_-RIGHT__Profilin-_Complex__Actin_Actin_-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 968
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 966
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 967
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 965
left: Actin
left: Complex (Profilin/Actin)
interaction type: STATE_TRANSITION
right: Profilin
right: Complex (Actin/Actin)

PTHR11588:SF112
type: RelationshipXref
id: PTHR11588:SF112
db: PANTHER Family
relationship type: By Homology

uniprot Q8QFP8 715
type: UnificationXref
id: Q8QFP8
db: uniprot

uniprot Q8VDD5 664
type: UnificationXref
id: Q8VDD5
db: uniprot

PTHR11588:SF116
type: RelationshipXref
id: PTHR11588:SF116
db: PANTHER Family
relationship type: By Homology

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF247
xref: uniprot Q0IIR4 824
organism: Xenopus tropicalis

uniprot P69897 821
type: UnificationXref
id: P69897
db: uniprot

uniprot F6W5V4 522
type: UnificationXref
id: F6W5V4
db: uniprot

uniprot Q8WXR4 665
type: UnificationXref
id: Q8WXR4
db: uniprot

Tubulin beta-7 chain
type: ProteinReference
xref: uniprot P37832 812
xref: PTHR11588:SF339
organism: Oryza sativa

uniprot Q7PSI4 863
type: UnificationXref
id: Q7PSI4
db: uniprot

T508 LIMK s33 a48 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY T508
feature location: T508 LIMK s33 a48 rs1 T508
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=T508
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q03048 63
type: UnificationXref
id: Q03048
db: uniprot

Myosin heavy chain 14
type: ProteinReference
xref: uniprot F1PYS6 603
organism: Canis lupus familiaris

Complex (Actin/Actin)
type: Complex
component: Actin
feature: COMPLEX BINDING FEATURE s27 a39 910

uniprot P85298 525
type: UnificationXref
id: P85298
db: uniprot

Cofilin
type: ProteinReference
xref: uniprot Q03048 63
organism: Saccharomyces cerevisiae

Actin, cytoplasmic 2
type: ProteinReference
xref: PTHR11937:SF362
xref: uniprot Q7ZVF9 367
organism: Danio rerio

uniprot F6VF32 611
type: UnificationXref
id: F6VF32
db: uniprot

uniprot A8XIF5 12
type: UnificationXref
id: A8XIF5
db: uniprot

uniprot Q94KS3 562
type: UnificationXref
id: Q94KS3
db: uniprot

uniprot P12411 805
type: UnificationXref
id: P12411
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UA63 258
xref: PTHR11937:SF201
organism: Macaca mulatta

uniprot H2QC99 628
type: UnificationXref
id: H2QC99
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F6ZCX3 771
xref: PTHR11588:SF112
organism: Monodelphis domestica

tubulin
type: ProteinReference
xref: P00526
standard name: Tubulin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.tubulin
comment: ENTITY_REFERENCE_NOTES=Long Name: Tubulin Synonym: Synonym not specified Accession: P00526
member entity reference: Tubulin beta-5 chain
member entity reference: Tubulin beta chain
member entity reference: Tubulin beta-3 chain
member entity reference: Tubulin beta-4A chain
member entity reference: Tubulin beta-6 chain
member entity reference: Tubulin beta-4 chain
member entity reference: Melanocyte-stimulating hormone receptor
member entity reference: Tubulin beta-1 chain
member entity reference: Tubulin beta-4B chain
member entity reference: Tubulin beta-8 chain
member entity reference: Tubulin beta chain (Fragment)
member entity reference: Tubulin beta-2 chain
member entity reference: Tubulin beta-2B chain

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa9 889
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Myosin-10
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot Q27991 653
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__LIMK-RIGHT__LIMK-_r31
controller: PAK

uniprot Q9Z207 83
type: UnificationXref
id: Q9Z207
db: uniprot

Actin, alpha 2, smooth muscle, aorta
type: ProteinReference
xref: uniprot F2Z4N0 248
xref: PTHR11937:SF201
organism: Canis lupus familiaris

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot W4YBZ7 880
organism: Strongylocentrotus purpuratus

Profilin-3
type: ProteinReference
xref: uniprot Q38904 557
organism: Arabidopsis thaliana

Actin, gamma 2, smooth muscle, enteric
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot F2Z4N8 250
organism: Canis lupus familiaris

Actin, alpha, cardiac muscle 1
type: ProteinReference
xref: PTHR11937:SF176
xref: uniprot F2Z4N7 249
organism: Canis lupus familiaris

uniprot F6V4Y9 78
type: UnificationXref
id: F6V4Y9
db: uniprot

uniprot Q3SYX9 147
type: UnificationXref
id: Q3SYX9
db: uniprot

Rho-related GTP-binding protein RhoJ
type: ProteinReference
xref: uniprot Q9ER71 44
xref: PTHR24072:SF17
organism: Mus musculus

uniprot P10987 291
type: UnificationXref
id: P10987
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 7

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR48015:SF30
xref: uniprot F1N8W8 462
organism: Gallus gallus

Actin alpha cardiac muscle 1b
type: ProteinReference
xref: uniprot Q9I8V1 375
xref: PTHR11937:SF184
organism: Danio rerio

MYH10 isoform 1
type: ProteinReference
xref: uniprot A0A2I3RXX2 573
xref: PTHR45615:SF24
organism: Pan troglodytes

uniprot H3FCG4 277
type: UnificationXref
id: H3FCG4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF359
xref: uniprot H3F5B4 276
organism: Pristionchus pacificus

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 393

uniprot F0Z6V2 99
type: UnificationXref
id: F0Z6V2
db: uniprot

Actin
type: ProteinReference
xref: uniprot Q7YTV5 366
xref: PTHR11937:SF387
organism: Trichoplax adhaerens

STATE_TRANSITION_LEFT__Complex__GDP_Cdc42_-RIGHT__Complex__Cdc42_GTP_-_r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 920
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 921
left: Complex (GDP/Cdc42)
interaction type: STATE_TRANSITION
right: Complex (Cdc42/GTP)

uniprot Q6P8G3 360
type: UnificationXref
id: Q6P8G3
db: uniprot

Profilin-2
type: ProteinReference
xref: uniprot P35080 548
organism: Homo sapiens

uniprot D4A280 453
type: UnificationXref
id: D4A280
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 216

uniprot Q8N8S7 446
type: UnificationXref
id: Q8N8S7
db: uniprot

uniprot F1A175 244
type: UnificationXref
id: F1A175
db: uniprot

Cofilin
type: Protein
entity reference: Cofilin
feature: S3 Cofilin s32 a47 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot A7S0V7 188
type: UnificationXref
id: A7S0V7
db: uniprot

uniprot Q6TYS2 361
type: UnificationXref
id: Q6TYS2
db: uniprot

uniprot Q5FWK3 529
type: UnificationXref
id: Q5FWK3
db: uniprot

uniprot P09653 802
type: UnificationXref
id: P09653
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6TWF0 464
organism: Macaca mulatta

AGAP000406-PA
type: ProteinReference
xref: uniprot Q7PRV2 515
organism: Anopheles gambiae

STATE_TRANSITION_LEFT__Complex__GDP_Rho_-RIGHT__Complex__Rho_GTP_-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 939
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 938
left: Complex (GDP/Rho)
interaction type: STATE_TRANSITION
right: Complex (Rho/GTP)

uniprot A3C6D7 184
type: UnificationXref
id: A3C6D7
db: uniprot

uniprot Q9EPC6 564
type: UnificationXref
id: Q9EPC6
db: uniprot

Putative actin-22
type: ProteinReference
xref: PTHR11937:SF421
xref: uniprot Q553U6 343
organism: Dictyostelium discoideum

Slingshot
type: ProteinReference
xref: P00509
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Slingshot Synonym: SSH Accession: P00509
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Slingshot
member entity reference: Protein phosphatase Slingshot
member entity reference: Protein phosphatase Slingshot homolog 3
member entity reference: Protein phosphatase Slingshot homolog 1
member entity reference: Uncharacterized protein
member entity reference: Protein phosphatase Slingshot homolog 2

Actin, gamma
type: ProteinReference
xref: uniprot P20359 295
xref: PTHR11937:SF387
organism: Emericella nidulans

Serine/threonine-protein kinase PAK 1
type: ProteinReference
xref: uniprot Q08E52 479
xref: PTHR48015:SF20
organism: Bos taurus

Complex (Profilin/Actin)
type: Complex
component stoichiometry: Profilin s50 sa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: Actin s51 sa18 STOICHIOMETRY ID COMPLEX
component: Actin
component: Profilin
feature: COMPLEX BINDING FEATURE s30 a45 904
feature: COMPLEX BINDING FEATURE s30 a45 902

Tubulin beta chain
type: ProteinReference
xref: uniprot Q6GLE7 847
xref: PTHR11588:SF61
organism: Xenopus tropicalis

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 27

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ROCK-RIGHT__ROCK-_r35
controller: Complex (Rho/GTP)

Tubulin beta-2 chain
type: ProteinReference
xref: PTHR11588:SF291
xref: uniprot P10874 804
organism: Emericella nidulans

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot F7FAW0 619
organism: Monodelphis domestica

Uncharacterized protein
type: ProteinReference
xref: uniprot E9HL06 16
xref: PTHR24072:SF168
organism: Daphnia pulex

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A2J8MSR9 447
organism: Pan troglodytes

Rac family small GTPase 1a
type: ProteinReference
xref: uniprot Q7ZSZ9 704
xref: PTHR24072:SF105
organism: Danio rerio

uniprot F6Q4N4 535
type: UnificationXref
id: F6Q4N4
db: uniprot

uniprot P07829 283
type: UnificationXref
id: P07829
db: uniprot

MYH9 isoform 1
type: ProteinReference
xref: uniprot A0A2I3SQU2 575
organism: Pan troglodytes

uniprot Q13885 826
type: UnificationXref
id: Q13885
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q4Q4C4 839
organism: Leishmania major

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot E3K4I1 236
organism: Puccinia graminis

uniprot Q7YQL4 488
type: UnificationXref
id: Q7YQL4
db: uniprot

uniprot F1M775 77
type: UnificationXref
id: F1M775
db: uniprot

Pi
type: SmallMolecule
comment: SPECIES_TYPE=ION

uniprot F1QVX3 604
type: UnificationXref
id: F1QVX3
db: uniprot

uniprot Q6NN85 72
type: UnificationXref
id: Q6NN85
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y6B5 523
organism: Macaca mulatta

uniprot F1MZX6 595
type: UnificationXref
id: F1MZX6
db: uniprot

uniprot F7GL73 270
type: UnificationXref
id: F7GL73
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF468
xref: uniprot C3Z4K3 230
organism: Branchiostoma floridae

uniprot P39825 549
type: UnificationXref
id: P39825
db: uniprot

uniprot P62739 312
type: UnificationXref
id: P62739
db: uniprot

uniprot W4YEV4 881
type: UnificationXref
id: W4YEV4
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A2DC16 730
organism: Trichomonas vaginalis

uniprot Q5ZL50 560
type: UnificationXref
id: Q5ZL50
db: uniprot

uniprot F6ZZG9 261
type: UnificationXref
id: F6ZZG9
db: uniprot

AGAP001676-PA
type: ProteinReference
xref: uniprot Q7PXZ8 365
xref: PTHR11937:SF397
organism: Anopheles gambiae

Rho associated coiled-coil containing protein kinase 1
type: ProteinReference
xref: uniprot F7G2Y1 504
xref: PTHR22988:SF33
organism: Monodelphis domestica

uniprot F6V9E8 385
type: UnificationXref
id: F6V9E8
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F7HTD6 780
xref: PTHR11588:SF330
organism: Macaca mulatta

uniprot A0A2I3TJW3 401
type: UnificationXref
id: A0A2I3TJW3
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot Q9VX82 169
organism: Drosophila melanogaster

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot B7PA92 745
organism: Ixodes scapularis

uniprot F7EU36 267
type: UnificationXref
id: F7EU36
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A9V489 208
organism: Monosiga brevicollis

Tubulin beta chain
type: ProteinReference
xref: uniprot B7PA95 746
xref: PTHR11588:SF314
organism: Ixodes scapularis

uniprot A2DC16 730
type: UnificationXref
id: A2DC16
db: uniprot

Actin, alpha cardiac muscle 2
type: ProteinReference
xref: uniprot P20399 296
xref: PTHR11937:SF416
organism: Xenopus tropicalis

Actin-related protein 2/3 complex subunit 2
type: ProteinReference
xref: uniprot O14241 119
organism: Schizosaccharomyces pombe

S3 Cofilin s32 a47 rs1
type: ModificationFeature
feature location type: SEQUENCE REGION VOCABULARY S3
feature location: S3 Cofilin s32 a47 rs1 S3
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793
comment: MODIFICATION_RESIDUE_NAME=S3

uniprot A2AQ07 729
type: UnificationXref
id: A2AQ07
db: uniprot

uniprot Q4QI42 841
type: UnificationXref
id: Q4QI42
db: uniprot

uniprot Q8BFZ3 369
type: UnificationXref
id: Q8BFZ3
db: uniprot

Profilin
type: Protein
entity reference: Profilin
comment: SPECIES_TYPE=PROTEIN

Rho GTPase-activating protein 1
type: ProteinReference
xref: PTHR45808:SF6
xref: uniprot D4A6C5 519
organism: Rattus norvegicus

Profilin-1
type: ProteinReference
xref: uniprot P07737 544
organism: Homo sapiens

Putative actin-23
type: ProteinReference
xref: uniprot Q55EU6 344
xref: PTHR11937:SF154
organism: Dictyostelium discoideum

uniprot Q3T0C7 399
type: UnificationXref
id: Q3T0C7
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot F2Z4P1 763
organism: Canis lupus familiaris

Complex (GDP/Rho)
type: Complex
component stoichiometry: Rho s28 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s21 sa9 STOICHIOMETRY ID COMPLEX
component: Rho
component: GDP
feature: COMPLEX BINDING FEATURE s23 a34 890
feature: COMPLEX BINDING FEATURE s23 a34 888

uniprot B3RX77 213
type: UnificationXref
id: B3RX77
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot H2QP14 474
xref: PTHR48015:SF22
organism: Pan troglodytes

Actin, cytoplasmic 1
type: ProteinReference
xref: uniprot P60710 307
xref: PTHR11937:SF192
organism: Mus musculus

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60711 308
organism: Rattus norvegicus

Tubulin beta-3 chain
type: ProteinReference
xref: PTHR11588:SF43
xref: uniprot Q2T9S0 831
organism: Bos taurus

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60712 309
organism: Bos taurus

Tubulin beta chain
type: ProteinReference
xref: uniprot C3YMF1 752
xref: PTHR11588:SF89
organism: Branchiostoma floridae

uniprot A0A2J8MSR9 447
type: UnificationXref
id: A0A2J8MSR9
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF88
xref: uniprot H2RB52 785
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r34 931
type: Stoichiometry
physical entity: Cofilin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 930
type: Stoichiometry
physical entity: Cofilin
stoichiometric coefficient: 1.0

Complex (tubulin/tubulin)
type: Complex
component: tubulin
feature: COMPLEX BINDING FEATURE s37 a57 896

Actin-like protein 53D
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot P45891 297
organism: Drosophila melanogaster

Rho-related GTP-binding protein RhoU
type: ProteinReference
xref: uniprot Q9EQT3 434
organism: Mus musculus

Evidence 394
type: Evidence
evidence code: IEA
comment: Website http://www.ncbi.nlm.nih.gov/LocusLink/LocRpt.cgi?l=3925

uniprot Q6P378 358
type: UnificationXref
id: Q6P378
db: uniprot

Myosin-2
type: ProteinReference
xref: PTHR34491:SF33
xref: uniprot F1MRC2 594
organism: Bos taurus

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60709 306
organism: Homo sapiens

uniprot F7F210 268
type: UnificationXref
id: F7F210
db: uniprot

tubulin
type: Complex
component stoichiometry: tubulin s52 sa19 STOICHIOMETRY ID COMPLEX
component: tubulin
feature: COMPLEX PARTICIPANT BINDING FEATURE s52 sa19 897

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF192
xref: uniprot P60706 305
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF39
xref: uniprot F6Y1M7 613
organism: Macaca mulatta

Profilin
type: ProteinReference
xref: P00521
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Profilin
comment: ENTITY_REFERENCE_NOTES=Long Name: Profilin Synonym: PFN Accession: P00521
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Profilin
member entity reference: Profilin-3
member entity reference: Profilin-1
member entity reference: Profilin-2
member entity reference: Profilin-A
member entity reference: Profilin-5

uniprot C3ZMR2 233
type: UnificationXref
id: C3ZMR2
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot P40518 136
organism: Saccharomyces cerevisiae

uniprot F1PT97 102
type: UnificationXref
id: F1PT97
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A7S8I3 734
organism: Nematostella vectensis

Protein diaphanous homolog 2
type: ProteinReference
xref: uniprot O60879 82
organism: Homo sapiens

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 185

uniprot F7FN72 111
type: UnificationXref
id: F7FN72
db: uniprot

uniprot P20399 296
type: UnificationXref
id: P20399
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot W4X9L8 875
organism: Strongylocentrotus purpuratus

uniprot C4M8K6 679
type: UnificationXref
id: C4M8K6
db: uniprot

Rho-associated protein kinase 1
type: ProteinReference
xref: PTHR22988:SF33
xref: uniprot Q63644 514
organism: Rattus norvegicus

Myosin-8
type: ProteinReference
xref: uniprot P13542 644
xref: PTHR45615:SF35
organism: Mus musculus

Myosin-3
type: ProteinReference
xref: PTHR45615:SF6
xref: uniprot P13541 643
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5NUE9 569
xref: PTHR45615:SF24
organism: Gallus gallus

Profilin-2
type: ProteinReference
xref: uniprot Q09430 553
organism: Bos taurus

GDP s21 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot P10981 288
type: UnificationXref
id: P10981
db: uniprot

uniprot L7N3Q3 791
type: UnificationXref
id: L7N3Q3
db: uniprot

uniprot Q9VMH2 168
type: UnificationXref
id: Q9VMH2
db: uniprot

mDia
type: Protein
entity reference: mDia
comment: SPECIES_TYPE=PROTEIN

uniprot A9RQS1 741
type: UnificationXref
id: A9RQS1
db: uniprot

uniprot Q23130 527
type: UnificationXref
id: Q23130
db: uniprot

Actin alpha 2, smooth muscle
type: ProteinReference
xref: PTHR11937:SF445
xref: uniprot Q6DHS1 354
organism: Danio rerio

uniprot F6YTJ1 614
type: UnificationXref
id: F6YTJ1
db: uniprot

uniprot P12456 806
type: UnificationXref
id: P12456
db: uniprot

Cell division cycle 42
type: ProteinReference
xref: PTHR24072:SF337
xref: uniprot Q52WY2 430
organism: Danio rerio

Rho GTPase activating protein 1
type: ProteinReference
xref: uniprot F6W5V4 522
xref: PTHR45808:SF6
organism: Monodelphis domestica

uniprot Q67G20 353
type: UnificationXref
id: Q67G20
db: uniprot

mDia
type: Protein
entity reference: mDia
feature: ACTIVE 48
comment: SPECIES_TYPE=PROTEIN

PTHR24072:SF337
type: RelationshipXref
id: PTHR24072:SF337
db: PANTHER Family
relationship type: By Homology

uniprot P60673 550
type: UnificationXref
id: P60673
db: uniprot

…
type: Stoichiometry
physical entity: tubulin
stoichiometric coefficient: 4.0

uniprot Q9ER71 44
type: UnificationXref
id: Q9ER71
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF6
xref: uniprot F7GP56 623
organism: Macaca mulatta

uniprot P52275 816
type: UnificationXref
id: P52275
db: uniprot

PTHR22988:SF33
type: RelationshipXref
id: PTHR22988:SF33
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5PEI5 725
type: UnificationXref
id: A0A1D5PEI5
db: uniprot

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 15

uniprot Q7L0Q8 431
type: UnificationXref
id: Q7L0Q8
db: uniprot

uniprot Q05933 142
type: UnificationXref
id: Q05933
db: uniprot

Tubulin beta-2B chain
type: ProteinReference
xref: PTHR11588:SF330
xref: uniprot Q3KRE8 832
organism: Rattus norvegicus

PTHR11588:SF404
type: RelationshipXref
id: PTHR11588:SF404
db: PANTHER Family
relationship type: By Homology

PTHR24072:SF325
type: RelationshipXref
id: PTHR24072:SF325
db: PANTHER Family
relationship type: By Homology

uniprot M0RC65 56
type: UnificationXref
id: M0RC65
db: uniprot

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: uniprot Q7PWN2 156
xref: PTHR10709:SF2
organism: Anopheles gambiae

Ras homolog family member B
type: ProteinReference
xref: PTHR24072:SF0
xref: uniprot F7FR08 22
organism: Ornithorhynchus anatinus

Uncharacterized protein
type: ProteinReference
xref: PTHR45615:SF1
xref: uniprot A0A1D5QVF5 570
organism: Macaca mulatta

uniprot E9HEX5 759
type: UnificationXref
id: E9HEX5
db: uniprot

uniprot Q61879 657
type: UnificationXref
id: Q61879
db: uniprot

Serine/threonine-protein kinase PAK 6
type: ProteinReference
xref: uniprot Q9NQU5 492
organism: Homo sapiens

Tubulin beta chain
type: ProteinReference
xref: uniprot F7DCY3 776
xref: PTHR11588:SF55
organism: Macaca mulatta

uniprot P35080 548
type: UnificationXref
id: P35080
db: uniprot

Profilin-3
type: ProteinReference
xref: uniprot Q8T8M2 561
organism: Dictyostelium discoideum

Rho-associated protein kinase 2
type: ProteinReference
xref: uniprot O75116 507
organism: Homo sapiens

GTP-binding protein rho5
type: ProteinReference
xref: uniprot Q9HE04 45
xref: PTHR24072:SF168
organism: Schizosaccharomyces pombe

Rac family small GTPase 2
type: ProteinReference
xref: uniprot Q5U1Y2 697
xref: PTHR24072:SF169
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r36 926
type: Stoichiometry
physical entity: Cofilin
stoichiometric coefficient: 1.0

uniprot P40792 689
type: UnificationXref
id: P40792
db: uniprot

PTHR12391:SF4
type: RelationshipXref
id: PTHR12391:SF4
db: PANTHER Family
relationship type: By Homology

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa7 913
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__tubulin-RIGHT__Complex__tubulin_tubulin_-_r38
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 924
participant stoichiometry: PARTICIPANT STOICHIOMETRY r38 925
left: tubulin
interaction type: STATE_TRANSITION
right: Complex (tubulin/tubulin)

PARTICIPANT STOICHIOMETRY r20 920
type: Stoichiometry
physical entity: Complex (GDP/Cdc42)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 921
type: Stoichiometry
physical entity: Complex (Cdc42/GTP)
stoichiometric coefficient: 1.0

PTHR24072:SF310
type: RelationshipXref
id: PTHR24072:SF310
db: PANTHER Family
relationship type: By Homology

PTHR12391:SF1
type: RelationshipXref
id: PTHR12391:SF1
db: PANTHER Family
relationship type: By Homology

PTHR12391:SF0
type: RelationshipXref
id: PTHR12391:SF0
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r36 927
type: Stoichiometry
physical entity: Cofilin
stoichiometric coefficient: 1.0

Rho GTPase Activating protein
type: ProteinReference
xref: uniprot Q23130 527
organism: Caenorhabditis elegans

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 35

Actin
type: ProteinReference
xref: uniprot Q75D00 363
xref: PTHR11937:SF387
organism: Ashbya gossypii

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 47

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RE16 458
organism: Canis lupus familiaris

uniprot E1BA03 454
type: UnificationXref
id: E1BA03
db: uniprot

uniprot A8WS32 196
type: UnificationXref
id: A8WS32
db: uniprot

uniprot Q22038 37
type: UnificationXref
id: Q22038
db: uniprot

Profilin
type: ProteinReference
xref: uniprot E1BHJ0 534
organism: Bos taurus

Ras homolog family member J
type: ProteinReference
xref: uniprot F1PYF1 18
xref: PTHR24072:SF17
organism: Canis lupus familiaris

uniprot F7GY91 684
type: UnificationXref
id: F7GY91
db: uniprot

uniprot Q9VRX3 874
type: UnificationXref
id: Q9VRX3
db: uniprot

ncbitaxon 5722 181
type: UnificationXref
id: 5722
db: ncbitaxon

uniprot C3ZHN2 231
type: UnificationXref
id: C3ZHN2
db: uniprot

Batrachochytrium dendrobatidis
type: BioSource
xref: ncbitaxon 684364 765

uniprot A7SJX9 736
type: UnificationXref
id: A7SJX9
db: uniprot

uniprot Q03173 445
type: UnificationXref
id: Q03173
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6R9F4 252
xref: PTHR11937:SF446
organism: Monodelphis domestica

uniprot P31395 395
type: UnificationXref
id: P31395
db: uniprot

uniprot Q6IQJ2 848
type: UnificationXref
id: Q6IQJ2
db: uniprot

uniprot O08808 80
type: UnificationXref
id: O08808
db: uniprot

uniprot F1N8W8 462
type: UnificationXref
id: F1N8W8
db: uniprot

Stathmin
type: ProteinReference
xref: uniprot P31395 395
organism: Gallus gallus

Actin, indirect flight muscle
type: ProteinReference
xref: uniprot P83967 332
xref: PTHR11937:SF397
organism: Drosophila melanogaster

uniprot F6UDX9 259
type: UnificationXref
id: F6UDX9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Myosin-RIGHT__Myosin-_r43
controller: MLCK

uniprot F1RCB6 247
type: UnificationXref
id: F1RCB6
db: uniprot

Tubulin beta-2A chain
type: ProteinReference
xref: PTHR11588:SF100
xref: uniprot P85108 822
organism: Rattus norvegicus

uniprot A0A3Q2TTH6 500
type: UnificationXref
id: A0A3Q2TTH6
db: uniprot

uniprot Q61036 485
type: UnificationXref
id: Q61036
db: uniprot

uniprot H2Q860 54
type: UnificationXref
id: H2Q860
db: uniprot

Serine/threonine-protein kinase PAK 5
type: ProteinReference
xref: uniprot D4A280 453
organism: Rattus norvegicus

uniprot Q13464 511
type: UnificationXref
id: Q13464
db: uniprot

Protein diaphanous homolog 1
type: ProteinReference
xref: uniprot F1M775 77
organism: Rattus norvegicus

Slingshot
type: Protein
entity reference: Slingshot
comment: SPECIES_TYPE=PROTEIN

PTHR34491:SF33
type: RelationshipXref
id: PTHR34491:SF33
db: PANTHER Family
relationship type: By Homology

Rop-family small GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot A9TLC7 675
organism: Physcomitrella patens

uniprot A0A0G2K6I4 436
type: UnificationXref
id: A0A0G2K6I4
db: uniprot

GTP s15 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot H2QCA0 629
type: UnificationXref
id: H2QCA0
db: uniprot

uniprot Q6TYR6 855
type: UnificationXref
id: Q6TYR6
db: uniprot

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: uniprot A0A2I3TL93 86
xref: PTHR12058:SF0
organism: Pan troglodytes

Actin
type: Protein
entity reference: Actin
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa18 905
comment: SPECIES_TYPE=PROTEIN

uniprot Q42418 558
type: UnificationXref
id: Q42418
db: uniprot

uniprot B6RK61 585
type: UnificationXref
id: B6RK61
db: uniprot

uniprot F6WFN3 612
type: UnificationXref
id: F6WFN3
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 294

ncbitaxon 13616 21
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot Q5ZJI7 151
type: UnificationXref
id: Q5ZJI7
db: uniprot

uniprot A2G1K5 182
type: UnificationXref
id: A2G1K5
db: uniprot

uniprot P45591 60
type: UnificationXref
id: P45591
db: uniprot

Actin-related protein 2/3 complex subunit 3
type: ProteinReference
xref: PTHR12391:SF0
xref: uniprot A8XMP5 89
organism: Caenorhabditis briggsae

Alpha-cardiac actin
type: ProteinReference
xref: uniprot F7F210 268
xref: PTHR11937:SF176
organism: Macaca mulatta

actin, muscle-like
type: ProteinReference
xref: uniprot A0A1W2WEN5 176
organism: Ciona intestinalis

Actin, alpha, cardiac muscle 1a
type: ProteinReference
xref: PTHR11937:SF150
xref: uniprot F1RCB6 247
organism: Danio rerio

uniprot H2QZG8 630
type: UnificationXref
id: H2QZG8
db: uniprot

uniprot Q17QZ0 483
type: UnificationXref
id: Q17QZ0
db: uniprot

Myosin, heavy chain a
type: ProteinReference
xref: uniprot F1R6C7 606
organism: Danio rerio

uniprot Q54GX7 342
type: UnificationXref
id: Q54GX7
db: uniprot

uniprot B8A561 586
type: UnificationXref
id: B8A561
db: uniprot

Actin
type: ProteinReference
xref: uniprot Q67G20 353
xref: PTHR11937:SF474
organism: Oryza sativa

CATALYSIS
type: Catalysis
controlled: HETERODIMER_ASSOCIATION_LEFT__ARP2_3-_N_WASP-RIGHT__Complex__N_WASP_ARP2__3_-_r48
controller: Complex (Rac/GTP)

PTHR11937:SF389
type: RelationshipXref
id: PTHR11937:SF389
db: PANTHER Family
relationship type: By Homology

uniprot Q8K3H5 662
type: UnificationXref
id: Q8K3H5
db: uniprot

uniprot Q6NX11 66
type: UnificationXref
id: Q6NX11
db: uniprot

PTHR11937:SF387
type: RelationshipXref
id: PTHR11937:SF387
db: PANTHER Family
relationship type: By Homology

uniprot O88656 126
type: UnificationXref
id: O88656
db: uniprot

ncbitaxon 7955 158
type: UnificationXref
id: 7955
db: ncbitaxon

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C4M5Z7 678
organism: Entamoeba histolytica

uniprot B1N2P0 210
type: UnificationXref
id: B1N2P0
db: uniprot

uniprot F1NYB1 761
type: UnificationXref
id: F1NYB1
db: uniprot

Rho GEFs
type: Protein
entity reference: Rho GEFs
comment: SPECIES_TYPE=PROTEIN

Myosin s40 a60 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot P05220 796
organism: Neurospora crassa

uniprot A0A2I3RHK4 571
type: UnificationXref
id: A0A2I3RHK4
db: uniprot

PTHR24347:SF373
type: RelationshipXref
id: PTHR24347:SF373
db: PANTHER Family
relationship type: By Homology

PTHR11937:SF397
type: RelationshipXref
id: PTHR11937:SF397
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 128

Myosin-IIIa
type: ProteinReference
xref: uniprot Q8K3H5 662
organism: Mus musculus

PTHR11202:SF12
type: RelationshipXref
id: PTHR11202:SF12
db: PANTHER Family
relationship type: By Homology

uniprot D3ZRN3 235
type: UnificationXref
id: D3ZRN3
db: uniprot

uniprot B3RIM6 14
type: UnificationXref
id: B3RIM6
db: uniprot

uniprot Q382F9 556
type: UnificationXref
id: Q382F9
db: uniprot

MYH11 protein
type: ProteinReference
xref: PTHR45615:SF23
xref: uniprot A6QLN6 581
organism: Bos taurus

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 340

Rho-associated protein kinase
type: ProteinReference
xref: uniprot Q9VXE3 516
organism: Drosophila melanogaster

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q05144 694
organism: Mus musculus

Thalassiosira pseudonana
type: BioSource
xref: ncbitaxon 35128 749

Serine/threonine-protein kinase PAK mbt
type: ProteinReference
xref: uniprot Q9VXE5 494
organism: Drosophila melanogaster

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 48
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 885
comment: SPECIES_TYPE=PROTEIN

uniprot F6XUU0 260
type: UnificationXref
id: F6XUU0
db: uniprot

Actin, alpha sarcomeric/skeletal
type: ProteinReference
xref: uniprot Q6P8G3 360
xref: PTHR11937:SF240
organism: Xenopus tropicalis

Stathmin-4
type: ProteinReference
xref: uniprot Q9H169 400
organism: Homo sapiens

By Homology
type: RelationshipTypeVocabulary

LIM domain kinase 1
type: ProteinReference
xref: uniprot P53668 713
organism: Mus musculus

uniprot F6R9F4 252
type: UnificationXref
id: F6R9F4
db: uniprot

uniprot W4XKG7 877
type: UnificationXref
id: W4XKG7
db: uniprot

LIM domain kinase 1
type: ProteinReference
xref: uniprot P53667 712
organism: Homo sapiens

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 11

uniprot P68033 322
type: UnificationXref
id: P68033
db: uniprot

LIM domain kinase 1
type: ProteinReference
xref: uniprot P53669 714
organism: Rattus norvegicus

Myosin
type: Protein
entity reference: Myosin
feature: ACTIVE 48
feature: Myosin s42 a62 rs1
comment: SPECIES_TYPE=PROTEIN

uniprot P13541 643
type: UnificationXref
id: P13541
db: uniprot

uniprot A0A2I3S4I6 2
type: UnificationXref
id: A0A2I3S4I6
db: uniprot

uniprot B1AR69 584
type: UnificationXref
id: B1AR69
db: uniprot

ncbitaxon 237561 25
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot W4XHC0 876
type: UnificationXref
id: W4XHC0
db: uniprot

uniprot J9P309 118
type: UnificationXref
id: J9P309
db: uniprot

uniprot C3XYC7 222
type: UnificationXref
id: C3XYC7
db: uniprot

uniprot P07830 284
type: UnificationXref
id: P07830
db: uniprot

ncbitaxon 9913 7
type: UnificationXref
id: 9913
db: ncbitaxon

Tubulin beta-2 chain
type: ProteinReference
xref: uniprot Q8H7U1 865
xref: PTHR11588:SF301
organism: Oryza sativa

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot A8BEI6 737
organism: Giardia intestinalis

uniprot A0A0D1DMT3 173
type: UnificationXref
id: A0A0D1DMT3
db: uniprot

uniprot P92199 510
type: UnificationXref
id: P92199
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot P05219 795
organism: Schizosaccharomyces pombe

uniprot P54227 396
type: UnificationXref
id: P54227
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Complex__GDP_Rac_-RIGHT__Complex__Rac_GTP_-_r19
controller: Rho GEFs

tubulin
type: Protein
entity reference: tubulin

uniprot P69895 820
type: UnificationXref
id: P69895
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H3FCG4 277
organism: Pristionchus pacificus

Myosin-10
type: ProteinReference
xref: PTHR45615:SF24
xref: uniprot P35580 646
organism: Homo sapiens

CFL2 isoform 1
type: ProteinReference
xref: uniprot H2Q860 54
organism: Pan troglodytes

uniprot F7ES59 20
type: UnificationXref
id: F7ES59
db: uniprot

uniprot A0A2I3T5A0 85
type: UnificationXref
id: A0A2I3T5A0
db: uniprot

uniprot F4P7H8 766
type: UnificationXref
id: F4P7H8
db: uniprot

uniprot B3RKR4 212
type: UnificationXref
id: B3RKR4
db: uniprot

Actin-related protein 2/3 complex subunit 5
type: ProteinReference
xref: uniprot G2HG81 114
xref: PTHR12644:SF1
organism: Pan troglodytes

Putative actin-5
type: ProteinReference
xref: uniprot Q8RYC2 373
xref: PTHR11937:SF411
organism: Arabidopsis thaliana

Myosin-9
type: ProteinReference
xref: PTHR45615:SF16
xref: uniprot F1P9J3 599
organism: Canis lupus familiaris

STATE_TRANSITION
type: InteractionVocabulary

Rho-associated protein kinase
type: ProteinReference
xref: uniprot H9G236 505
organism: Macaca mulatta

Tubulin beta chain
type: ProteinReference
xref: PTHR11588:SF9
xref: uniprot Q7PSI4 863
organism: Anopheles gambiae

uniprot P53492 300
type: UnificationXref
id: P53492
db: uniprot

PARTICIPANT STOICHIOMETRY r18 938
type: Stoichiometry
physical entity: Complex (GDP/Rho)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r18 939
type: Stoichiometry
physical entity: Complex (Rho/GTP)
stoichiometric coefficient: 1.0

uniprot Q6LC82 701
type: UnificationXref
id: Q6LC82
db: uniprot

PTHR11937:SF359
type: RelationshipXref
id: PTHR11937:SF359
db: PANTHER Family
relationship type: By Homology

Actin
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot A7ETS6 186
organism: Sclerotinia sclerotiorum

uniprot F7EGP4 538
type: UnificationXref
id: F7EGP4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11937:SF387
xref: uniprot F1A175 244
organism: Dictyostelium purpureum

uniprot P45891 297
type: UnificationXref
id: P45891
db: uniprot

uniprot F6U132 105
type: UnificationXref
id: F6U132
db: uniprot

Arp2/3 complex 34 kDa subunit
type: ProteinReference
xref: uniprot F1P1K3 101
xref: PTHR12058:SF0
organism: Gallus gallus

ncbitaxon 367110 331
type: UnificationXref
id: 367110
db: ncbitaxon

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF310
xref: uniprot C4M5T0 677
organism: Entamoeba histolytica

Tubulin beta-6 chain
type: ProteinReference
xref: uniprot Q9BUF5 868
xref: PTHR11588:SF88
organism: Homo sapiens

GTP-binding protein RHO1
type: ProteinReference
xref: uniprot P06780 28
organism: Saccharomyces cerevisiae

PTHR11937:SF362
type: RelationshipXref
id: PTHR11937:SF362
db: PANTHER Family
relationship type: By Homology

uniprot P08841 798
type: UnificationXref
id: P08841
db: uniprot

uniprot P09207 799
type: UnificationXref
id: P09207
db: uniprot

Tubulin beta chain
type: ProteinReference
xref: uniprot F6WYK8 769
xref: PTHR11588:SF247
organism: Monodelphis domestica

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 272

Myosin-8
type: ProteinReference
xref: PTHR45615:SF35
xref: uniprot Q076A4 649
organism: Canis lupus familiaris

uniprot P68372 819
type: UnificationXref
id: P68372
db: uniprot

Myosin-4
type: ProteinReference
xref: PTHR45615:SF2
xref: uniprot Q076A5 650
organism: Canis lupus familiaris

uniprot Q0IIR4 824
type: UnificationXref
id: Q0IIR4
db: uniprot

Myosin-1
type: ProteinReference
xref: PTHR45615:SF3
xref: uniprot Q076A6 651
organism: Canis lupus familiaris

Developmental myosin heavy chain embryonic
type: ProteinReference
xref: uniprot Q076A8 652
xref: PTHR45615:SF6
organism: Canis lupus familiaris

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XUP1 466
xref: PTHR48015:SF20
organism: Macaca mulatta

Actin, cytoplasmic 1
type: ProteinReference
xref: PTHR11937:SF477
xref: uniprot Q6NVA9 357
organism: Xenopus tropicalis

uniprot H2Q3I0 524
type: UnificationXref
id: H2Q3I0
db: uniprot

STATE_TRANSITION_LEFT__Complex__Cdc42_GTP_-RIGHT__Pi-_Complex__GDP_Cdc42_-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 944
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 943
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 945
left: Complex (Cdc42/GTP)
interaction type: STATE_TRANSITION
right: Pi
right: Complex (GDP/Cdc42)

Myosin-9
type: ProteinReference
xref: uniprot P35579 645
xref: PTHR45615:SF16
organism: Homo sapiens

uniprot F7DMM7 537
type: UnificationXref
id: F7DMM7
db: uniprot

Actin
type: ProteinReference
xref: PTHR11937:SF248
xref: uniprot Q75HX0 364
organism: Oryza sativa

Uncharacterized protein
type: ProteinReference
xref: uniprot B3RIM6 14
xref: PTHR24072:SF168
organism: Trichoplax adhaerens

Rho
type: ProteinReference
xref: P00507
standard name: Ras homologue gene family
comment: ENTITY_REFERENCE_ID_DESC=Cytoskeletal regulation by Rho GTPase.PROTEIN.GENERIC.Rho
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Uncharacterized protein
member entity reference: GTP-binding protein rho1
member entity reference: Predicted protein
member entity reference: Ras-like GTP-binding protein Rho1
member entity reference: Rho-related GTP-binding protein RhoC
member entity reference: GTP-binding protein RHO1
member entity reference: GTP-binding protein rho4
member entity reference: Rho-related GTP-binding protein RhoJ
member entity reference: RHOJ protein
member entity reference: Ras-like GTP-binding protein rhoA
member entity reference: GTP-binding protein rho5
member entity reference: RhoA protein
member entity reference: Ras homolog family member B
member entity reference: Protein CBR-RHO-1
member entity reference: GTP-binding protein rhoA
member entity reference: Ras homolog family member J
member entity reference: Ras homolog family member C
member entity reference: GTP-binding protein

Actin-related protein 2/3 complex subunit
type: ProteinReference
xref: PTHR10709:SF11
xref: uniprot F7BZM9 108
organism: Monodelphis domestica

PTHR24347:SF394
type: RelationshipXref
id: PTHR24347:SF394
db: PANTHER Family
relationship type: By Homology

Ras-related protein Rac2
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P48554 690
organism: Drosophila melanogaster

Profilin
type: ProteinReference
xref: uniprot P25843 545
organism: Drosophila melanogaster

uniprot B8A568 587
type: UnificationXref
id: B8A568
db: uniprot

Monosiga brevicollis
type: BioSource
xref: ncbitaxon 81824 209

Myosin-8
type: ProteinReference
xref: PTHR45615:SF35
xref: uniprot P13535 642
organism: Homo sapiens

Myosin-6
type: ProteinReference
xref: uniprot P13533 641
xref: PTHR45615:SF11
organism: Homo sapiens

uniprot Q9TU25 706
type: UnificationXref
id: Q9TU25
db: uniprot

uniprot H2QGF2 495
type: UnificationXref
id: H2QGF2
db: uniprot

uniprot P13535 642
type: UnificationXref
id: P13535
db: uniprot