Proliferating cell nuclear antigen
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot Q9PTP1 263
organism: Danio rerio

Histone H3
type: ProteinReference
xref: PTHR11426:SF101
xref: uniprot Q5KMT3 137
organism: Cryptococcus neoformans

Histone H3
type: ProteinReference
xref: uniprot C3XUS0 54
xref: PTHR11426:SF220
organism: Branchiostoma floridae

Histone H3.2
type: ProteinReference
xref: uniprot Q4PB04 132
xref: PTHR11426:SF47
organism: Ustilago maydis

ncbitaxon 3055 31
type: UnificationXref
id: 3055
db: ncbitaxon

uniprot F6ZD63 242
type: UnificationXref
id: F6ZD63
db: uniprot

DNA replication
type: Pathway
pathway component: STATE_TRANSITION_LEFT__dsDNA-_n_H2O-RIGHT__n_NMP-_dsDNA-_r68
pathway component: STATE_TRANSITION_LEFT__Chromatin__DNA__PLUS__Histones__PLUS__Other_Proteins_-RIGHT__Chromatin__DNA__PLUS__Histones__PLUS__Other_Proteins__Replication_Competant_State-_r1
pathway component: STATE_TRANSITION_LEFT__ATPs-_Complex__Pol_alpha_Primase_-_dsDNA-RIGHT__dsDNA_primase_complex-_ADPs__PLUS__Pi-_re11
pathway component: STATE_TRANSITION_LEFT__n_dNTP__PLUS__Mg_PLUS__PLUS_-_PCNA-_Pol_delta-_dsDNA_primase_RFC_complex-RIGHT__dsDNA_replication_complex-_nPPi-_r63
pathway component: STATE_TRANSITION_LEFT__dsDNA_replication_complex-RIGHT__dsDNA-_r67
pathway component: STATE_TRANSITION_LEFT__dsDNA-_Histones-_ATP-RIGHT__ADP__PLUS__Pi-_Chromatin__DNA__PLUS__Histones__PLUS__Other_Proteins_-_r69
pathway component: STATE_TRANSITION_LEFT__ATPs-_dsDNA_primase_complex-_RFC-RIGHT__ADPs__PLUS__Pi-_dsDNA_primase_RFC_complex-_re10
pathway component: HETERODIMER_ASSOCIATION_LEFT__Top-_Chromatin__DNA__PLUS__Histones__PLUS__Other_Proteins__Replication_Competant_State-_RPA-_Hel-_ATP-RIGHT__ADP__PLUS__Pi-_dsDNA-_r24
xref: PANTHER Pathway P00017 1
comment: MODEL_NOTES=Panther Pathway: P00017 A series of integrated protein-protein and protein-DNA interactions and enzymatic reactions to ensure high accuracy of DNA replication.

ncbitaxon 7739 53
type: UnificationXref
id: 7739
db: ncbitaxon

DNA polymerase delta catalytic subunit
type: ProteinReference
xref: PTHR10322:SF23
xref: uniprot P54358 231
organism: Drosophila melanogaster

Primase s92 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Primase
stoichiometric coefficient: 1.0

DNA topoisomerase 2-beta
type: ProteinReference
xref: uniprot O42131 273
organism: Gallus gallus

DNA topoisomerase 2-alpha
type: ProteinReference
xref: uniprot O42130 272
organism: Gallus gallus

ncbitaxon 237631 131
type: UnificationXref
id: 237631
db: ncbitaxon

Proliferating cell nuclear antigen
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot E2R0D6 239
organism: Canis lupus familiaris

Top s74 a138 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Top
stoichiometric coefficient: 1.0

Histone H3
type: ProteinReference
xref: uniprot F6PGA3 73
xref: PTHR11426:SF101
organism: Monodelphis domestica

uniprot O60930 293
type: UnificationXref
id: O60930
db: uniprot

Hel s64 a161 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hel
stoichiometric coefficient: 1.0

DNA topoisomerase 2-beta
type: ProteinReference
xref: uniprot Q64511 199
organism: Mus musculus

dsDNA s100 a99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 2.0

ncbitaxon 208964 304
type: UnificationXref
id: 208964
db: ncbitaxon

uniprot P15927 286
type: UnificationXref
id: P15927
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 11

ncbitaxon 81824 39
type: UnificationXref
id: 81824
db: ncbitaxon

uniprot Q6AXY4 234
type: UnificationXref
id: Q6AXY4
db: uniprot

Proliferating cell nuclear antigen
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot Q7KQJ9 255
organism: Plasmodium falciparum

DNA polymerase
type: ProteinReference
xref: PTHR45861:SF1
xref: uniprot Q57UW4 208
organism: Trypanosoma brucei

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dsDNA-_n_H2O-RIGHT__n_NMP-_dsDNA-_r68
controller: RNase H

ncbitaxon 83333 296
type: UnificationXref
id: 83333
db: ncbitaxon

Histone H3
type: ProteinReference
xref: uniprot B8CC53 49
xref: PTHR11426:SF190
organism: Thalassiosira pseudonana

uniprot Q9FJ79 283
type: UnificationXref
id: Q9FJ79
db: uniprot

uniprot G2J6C6 89
type: UnificationXref
id: G2J6C6
db: uniprot

ATPs
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H3EZY8 92
type: UnificationXref
id: H3EZY8
db: uniprot

PTHR11426:SF232
type: RelationshipXref
id: PTHR11426:SF232
db: PANTHER Family
relationship type: By Homology

dsDNA
type: DnaRegion
comment: SPECIES_TYPE=GENE

DNA topoisomerase 2
type: ProteinReference
xref: PTHR10169:SF50
xref: uniprot Q38EZ6 195
organism: Trypanosoma brucei

uniprot O42130 272
type: UnificationXref
id: O42130
db: uniprot

PTHR11426:SF231
type: RelationshipXref
id: PTHR11426:SF231
db: PANTHER Family
relationship type: By Homology

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 100

uniprot H2R5C2 221
type: UnificationXref
id: H2R5C2
db: uniprot

uniprot A8XPY9 37
type: UnificationXref
id: A8XPY9
db: uniprot

PTHR11426:SF236
type: RelationshipXref
id: PTHR11426:SF236
db: PANTHER Family
relationship type: By Homology

Histone H3
type: ProteinReference
xref: uniprot Q0UY45 124
xref: PTHR11426:SF101
organism: Phaeosphaeria nodorum

Histone H3
type: ProteinReference
xref: PTHR11426:SF20
xref: uniprot W4XJN4 148
organism: Strongylocentrotus purpuratus

ncbitaxon 5664 198
type: UnificationXref
id: 5664
db: ncbitaxon

Replication factor C (Activator 1) 5
type: ProteinReference
xref: uniprot B5DF29 163
organism: Rattus norvegicus

Histone H3.3
type: ProteinReference
xref: PTHR11426:SF228
xref: uniprot Q5E9F8 136
organism: Bos taurus

uniprot B5YMD6 44
type: UnificationXref
id: B5YMD6
db: uniprot

DNA polymerase
type: ProteinReference
xref: uniprot Q7KQL4 235
xref: PTHR10322:SF23
organism: Plasmodium falciparum

uniprot B7PAJ2 48
type: UnificationXref
id: B7PAJ2
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 7

Histone H3
type: ProteinReference
xref: PTHR11426:SF20
xref: uniprot P02299 97
organism: Drosophila melanogaster

Histone H3-like 5
type: ProteinReference
xref: uniprot Q9FKQ3 143
xref: PTHR11426:SF217
organism: Arabidopsis thaliana

5'->3' Exoribonulcease
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q5JF32 252
type: UnificationXref
id: Q5JF32
db: uniprot

RPA s98 a94 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RPA
stoichiometric coefficient: 4.0

uniprot F4P7A5 71
type: UnificationXref
id: F4P7A5
db: uniprot

uniprot Q2RAD9 129
type: UnificationXref
id: Q2RAD9
db: uniprot

DNA polymerase sliding clamp 2
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot Q8ZYL6 259
organism: Pyrobaculum aerophilum

uniprot P15348 189
type: UnificationXref
id: P15348
db: uniprot

uniprot F1PRA7 267
type: UnificationXref
id: F1PRA7
db: uniprot

PTHR10322:SF23
type: RelationshipXref
id: PTHR10322:SF23
db: PANTHER Family
relationship type: By Homology

Histone H3.1/H3.2
type: ProteinReference
xref: PTHR11426:SF101
xref: uniprot Q59VN2 133
organism: Candida albicans

uniprot Q1K7B3 233
type: UnificationXref
id: Q1K7B3
db: uniprot

Complex (Pol alpha/Primase)
type: Complex
component stoichiometry: Primase s4 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pol alpha s3 sa1 STOICHIOMETRY ID COMPLEX
component: Primase
component: Pol alpha
feature: COMPLEX BINDING FEATURE s37 a123 328
feature: COMPLEX BINDING FEATURE s37 a123 326

uniprot E3K5M6 66
type: UnificationXref
id: E3K5M6
db: uniprot

DNA topoisomerase 2
type: ProteinReference
xref: uniprot Q6RCM0 280
organism: Entamoeba histolytica

Complex (Pol alpha/Primase)
type: Complex
component stoichiometry: Primase s70 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pol alpha s69 sa8 STOICHIOMETRY ID COMPLEX
component: Pol alpha
component: Primase
feature: COMPLEX BINDING FEATURE s68 a202 330
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 a202 347
feature: COMPLEX BINDING FEATURE s68 a202 332

Histone H3
type: ProteinReference
xref: uniprot A7SX94 25
xref: PTHR11426:SF236
organism: Nematostella vectensis

Proliferating cell nuclear antigen
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot Q66KJ8 254
organism: Xenopus tropicalis

uniprot P0A7Y4 295
type: UnificationXref
id: P0A7Y4
db: uniprot

uniprot F6QR30 75
type: UnificationXref
id: F6QR30
db: uniprot

ssDNA s82 a139 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ssDNA
stoichiometric coefficient: 2.0

Histone H3
type: ProteinReference
xref: uniprot C3ZYM6 56
xref: PTHR11426:SF20
organism: Branchiostoma floridae

uniprot E3JT42 65
type: UnificationXref
id: E3JT42
db: uniprot

STATE_TRANSITION_LEFT__ATPs-_Complex__Pol_alpha_Primase_-_dsDNA-RIGHT__dsDNA_primase_complex-_ADPs__PLUS__Pi-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 397
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 398
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 400
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 399
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 401
left: ATPs
left: dsDNA
left: Complex (Pol alpha/Primase)
interaction type: STATE_TRANSITION
right: dsDNA-primase complex
right: ADPs + Pi

uniprot P52431 230
type: UnificationXref
id: P52431
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot E3KLF2 68
xref: PTHR11426:SF101
organism: Puccinia graminis

DNA polymerase sliding clamp
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot Q57697 250
organism: Methanocaldococcus jannaschii

Histone H3-like 1
type: ProteinReference
xref: PTHR11426:SF210
xref: uniprot Q9FX60 144
organism: Arabidopsis thaliana

uniprot P10651 107
type: UnificationXref
id: P10651
db: uniprot

uniprot Q9WUL0 200
type: UnificationXref
id: Q9WUL0
db: uniprot

Replication factor C subunit 4
type: ProteinReference
xref: uniprot Q99J62 175
organism: Mus musculus

uniprot Q5M830 171
type: UnificationXref
id: Q5M830
db: uniprot

uniprot Q64511 199
type: UnificationXref
id: Q64511
db: uniprot

RNA primer
type: DnaRegion
comment: SPECIES_TYPE=GENE

uniprot B0R0V1 218
type: UnificationXref
id: B0R0V1
db: uniprot

uniprot P54358 231
type: UnificationXref
id: P54358
db: uniprot

ADP + Pi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Histone H3
type: ProteinReference
xref: PTHR11426:SF101
xref: uniprot G2J6C6 89
organism: Caenorhabditis briggsae

ncbitaxon 64091 262
type: UnificationXref
id: 64091
db: ncbitaxon

ncbitaxon 3702 111
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot B3RWE2 41
type: UnificationXref
id: B3RWE2
db: uniprot

dsDNA-primase-RFC complex
type: Complex
component stoichiometry: Top s74 a138 STOICHIOMETRY ID COMPLEX
component stoichiometry: ssDNA s82 a139 STOICHIOMETRY ID COMPLEX
component stoichiometry: RFC s77 a151 STOICHIOMETRY ID COMPLEX
component stoichiometry: RPA s83 a140 STOICHIOMETRY ID COMPLEX
component stoichiometry: nascent DNA s39 a147 STOICHIOMETRY ID COMPLEX
component stoichiometry: dsDNA s72 a132 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex Pol alpha Primase s78 a203 STOICHIOMETRY ID COMPLEX
component stoichiometry: Hel s73 a133 STOICHIOMETRY ID COMPLEX
component: nascent DNA
component: Top
component: RFC
component: Hel
component: dsDNA
component: RPA
component: ssDNA
component: Complex (Pol alpha/Primase)
feature: COMPLEX BINDING FEATURE s81 csa11 322
feature: COMPLEX BINDING FEATURE s81 csa11 316
feature: COMPLEX BINDING FEATURE s81 csa11 310
feature: COMPLEX BINDING FEATURE s81 csa11 312
feature: COMPLEX BINDING FEATURE s81 csa11 324
feature: COMPLEX BINDING FEATURE s81 csa11 318
feature: COMPLEX BINDING FEATURE s81 csa11 320
feature: COMPLEX BINDING FEATURE s81 csa11 314

Histone H3
type: ProteinReference
xref: PTHR11426:SF20
xref: uniprot F6TK66 77
organism: Macaca mulatta

Hel
type: Protein
entity reference: Hel
feature: COMPLEX PARTICIPANT BINDING FEATURE s101 a103 373
comment: SPECIES_TYPE=PROTEIN

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 76

DNA topoisomerase 2-alpha
type: ProteinReference
xref: uniprot P41516 191
organism: Rattus norvegicus

tRNA-splicing ligase RtcB
type: ProteinReference
xref: uniprot Q8TU09 174
organism: Methanosarcina acetivorans

uniprot C6KT19 59
type: UnificationXref
id: C6KT19
db: uniprot

RPA s103 a106 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RPA
stoichiometric coefficient: 4.0

uniprot Q92373 290
type: UnificationXref
id: Q92373
db: uniprot

nascent DNA s62 a153 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: nascent DNA
stoichiometric coefficient: 1.0

dsDNA
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s95 a21 361
comment: SPECIES_TYPE=GENE

Histone H3
type: ProteinReference
xref: uniprot C6KT19 59
xref: PTHR11426:SF101
organism: Plasmodium falciparum

nascent DNA
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s39 a147 323
comment: SPECIES_TYPE=GENE

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 16

RFC
type: Protein
entity reference: RFC
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 a151 325
comment: SPECIES_TYPE=PROTEIN

DNA topoisomerase 2-alpha
type: ProteinReference
xref: uniprot P11388 188
organism: Homo sapiens

uniprot F7AME5 81
type: UnificationXref
id: F7AME5
db: uniprot

uniprot Q8ZTY0 257
type: UnificationXref
id: Q8ZTY0
db: uniprot

DNA topoisomerase 1
type: ProteinReference
xref: uniprot P11387 187
organism: Homo sapiens

DNA topoisomerase 2
type: ProteinReference
xref: uniprot F1MDU7 264
organism: Bos taurus

ncbitaxon 188937 16
type: UnificationXref
id: 188937
db: ncbitaxon

Hel s73 a133 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hel
stoichiometric coefficient: 1.0

Histone H3
type: ProteinReference
xref: uniprot A0A0G2K5X7 17
xref: PTHR11426:SF20
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r63 407
type: Stoichiometry
physical entity: n dNTP + Mg++
stoichiometric coefficient: 1.0

uniprot E9H1C5 69
type: UnificationXref
id: E9H1C5
db: uniprot

PARTICIPANT STOICHIOMETRY r63 408
type: Stoichiometry
physical entity: PCNA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 409
type: Stoichiometry
physical entity: Pol delta
stoichiometric coefficient: 1.0

uniprot P04961 244
type: UnificationXref
id: P04961
db: uniprot

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 258

DNA primase
type: ProteinReference
xref: PTHR10536:SF0
xref: uniprot A0A3Q1MF00 2
organism: Bos taurus

uniprot Q9LRE5 237
type: UnificationXref
id: Q9LRE5
db: uniprot

uniprot P0CO04 105
type: UnificationXref
id: P0CO04
db: uniprot

Histone H3.1t
type: ProteinReference
xref: PTHR11426:SF200
xref: uniprot Q16695 127
organism: Homo sapiens

uniprot P23753 108
type: UnificationXref
id: P23753
db: uniprot

uniprot G3MYD7 91
type: UnificationXref
id: G3MYD7
db: uniprot

Histone H3
type: ProteinReference
xref: PTHR45810:SF10
xref: uniprot F6QR30 75
organism: Macaca mulatta

PTHR11426:SF228
type: RelationshipXref
id: PTHR11426:SF228
db: PANTHER Family
relationship type: By Homology

Puccinia graminis
type: BioSource
xref: ncbitaxon 418459 64

PARTICIPANT STOICHIOMETRY r68 392
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 1.0

Pol alpha
type: Protein
entity reference: Pol alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 sa3 335
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r68 390
type: Stoichiometry
physical entity: n H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r68 391
type: Stoichiometry
physical entity: n NMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 412
type: Stoichiometry
physical entity: nPPi
stoichiometric coefficient: 1.0

DNA polymerase alpha catalytic subunit
type: ProteinReference
xref: PTHR45861:SF1
xref: uniprot P09884 205
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r63 410
type: Stoichiometry
physical entity: dsDNA-primase-RFC complex
stoichiometric coefficient: 1.0

PTHR11426:SF220
type: RelationshipXref
id: PTHR11426:SF220
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r63 411
type: Stoichiometry
physical entity: dsDNA-replication complex
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

RFC s6 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RFC
stoichiometric coefficient: 1.0

uniprot W4XW29 150
type: UnificationXref
id: W4XW29
db: uniprot

Histone H3.2
type: ProteinReference
xref: uniprot P59226 112
xref: PTHR11426:SF217
organism: Arabidopsis thaliana

Histone H3
type: ProteinReference
xref: uniprot F7GHH9 88
xref: PTHR11426:SF200
organism: Macaca mulatta

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 31

DNA primase small subunit
type: ProteinReference
xref: uniprot P20664 10
xref: PTHR10536:SF0
organism: Mus musculus

DNA polymerase delta catalytic subunit
type: ProteinReference
xref: uniprot P30316 226
xref: PTHR10322:SF23
organism: Schizosaccharomyces pombe

uniprot P84244 118
type: UnificationXref
id: P84244
db: uniprot

uniprot A8J9M0 32
type: UnificationXref
id: A8J9M0
db: uniprot

uniprot F6PLY1 220
type: UnificationXref
id: F6PLY1
db: uniprot

uniprot Q9I2S9 303
type: UnificationXref
id: Q9I2S9
db: uniprot

uniprot P08898 101
type: UnificationXref
id: P08898
db: uniprot

PTHR11426:SF217
type: RelationshipXref
id: PTHR11426:SF217
db: PANTHER Family
relationship type: By Homology

uniprot A7RJG4 21
type: UnificationXref
id: A7RJG4
db: uniprot

PTHR11426:SF214
type: RelationshipXref
id: PTHR11426:SF214
db: PANTHER Family
relationship type: By Homology

uniprot Q9PTP1 263
type: UnificationXref
id: Q9PTP1
db: uniprot

Histone H3
type: ProteinReference
xref: PTHR11426:SF101
xref: uniprot G2J6F9 90
organism: Caenorhabditis briggsae

Histone H3
type: ProteinReference
xref: uniprot E3K5M6 66
xref: PTHR11426:SF47
organism: Puccinia graminis

PTHR11426:SF218
type: RelationshipXref
id: PTHR11426:SF218
db: PANTHER Family
relationship type: By Homology

Histone H3
type: ProteinReference
xref: PTHR11426:SF236
xref: uniprot H3EZY8 92
organism: Pristionchus pacificus

uniprot H9FZ51 181
type: UnificationXref
id: H9FZ51
db: uniprot

DNA replication helicase/nuclease 2
type: ProteinReference
xref: uniprot A0A2I3RGW0 211
organism: Pan troglodytes

PTHR11426:SF210
type: RelationshipXref
id: PTHR11426:SF210
db: PANTHER Family
relationship type: By Homology

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 36

uniprot P53331 297
type: UnificationXref
id: P53331
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 102

PTHR11426:SF204
type: RelationshipXref
id: PTHR11426:SF204
db: PANTHER Family
relationship type: By Homology

DNA polymerase delta subunit 2
type: ProteinReference
xref: PTHR10416:SF0
xref: uniprot P49005 228
organism: Homo sapiens

PTHR11426:SF203
type: RelationshipXref
id: PTHR11426:SF203
db: PANTHER Family
relationship type: By Homology

DNA polymerase delta subunit 2
type: ProteinReference
xref: uniprot P49004 227
xref: PTHR10416:SF0
organism: Bos taurus

PTHR13710:SF132
type: RelationshipXref
id: PTHR13710:SF132
db: PANTHER Family
relationship type: By Homology

Histone H3
type: ProteinReference
xref: uniprot P07041 99
xref: PTHR11426:SF101
organism: Neurospora crassa

Pristionchus pacificus
type: BioSource
xref: ncbitaxon 54126 93

PTHR11426:SF200
type: RelationshipXref
id: PTHR11426:SF200
db: PANTHER Family
relationship type: By Homology

PTHR11426:SF201
type: RelationshipXref
id: PTHR11426:SF201
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR11426:SF192
xref: uniprot C3XPT8 52
organism: Branchiostoma floridae

uniprot Q10453 126
type: UnificationXref
id: Q10453
db: uniprot

Proliferating cell nuclear antigen
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot Q9DEA3 260
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR11426:SF220
xref: uniprot W4ZE70 160
organism: Strongylocentrotus purpuratus

uniprot W4YRX5 155
type: UnificationXref
id: W4YRX5
db: uniprot

uniprot Q57697 250
type: UnificationXref
id: Q57697
db: uniprot

PARTICIPANT STOICHIOMETRY r68 389
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 1.0

DNA topoisomerase 1
type: ProteinReference
xref: uniprot O17966 271
organism: Caenorhabditis elegans

DNA topoisomerase 2
type: ProteinReference
xref: uniprot P15348 189
organism: Drosophila melanogaster

uniprot A0A1D5Q2W2 201
type: UnificationXref
id: A0A1D5Q2W2
db: uniprot

uniprot E3KLF2 68
type: UnificationXref
id: E3KLF2
db: uniprot

uniprot P84228 117
type: UnificationXref
id: P84228
db: uniprot

P00531
type: UnificationXref
id: P00531
db: PANTHER Pathway Component

P00530
type: UnificationXref
id: P00530
db: PANTHER Pathway Component

DNA polymerase sliding clamp
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot Q9HN45 261
organism: Halobacterium salinarum

Uncharacterized protein
type: ProteinReference
xref: PTHR11426:SF101
xref: uniprot W4ZCB8 159
organism: Strongylocentrotus purpuratus

uniprot Q9UST8 305
type: UnificationXref
id: Q9UST8
db: uniprot

P00527
type: UnificationXref
id: P00527
db: PANTHER Pathway Component

P00528
type: UnificationXref
id: P00528
db: PANTHER Pathway Component

uniprot G2J6F9 90
type: UnificationXref
id: G2J6F9
db: uniprot

DNA polymerase
type: ProteinReference
xref: PTHR45861:SF1
xref: uniprot A0A1D5Q2W2 201
organism: Macaca mulatta

uniprot E3KAH9 67
type: UnificationXref
id: E3KAH9
db: uniprot

uniprot Q59VN2 133
type: UnificationXref
id: Q59VN2
db: uniprot

ncbitaxon 321614 125
type: UnificationXref
id: 321614
db: ncbitaxon

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 106

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 20

uniprot P59169 110
type: UnificationXref
id: P59169
db: uniprot

P00529
type: UnificationXref
id: P00529
db: PANTHER Pathway Component

Histone H3
type: ProteinReference
xref: uniprot C6KSV0 57
xref: PTHR11426:SF101
organism: Plasmodium falciparum

Ribonuclease HI
type: ProteinReference
xref: PTHR10642:SF23
xref: uniprot Q9I2S9 303
organism: Pseudomonas aeruginosa

n NMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O77321 224
type: UnificationXref
id: O77321
db: uniprot

uniprot Q4QEL1 207
type: UnificationXref
id: Q4QEL1
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot W4XKA2 149
xref: PTHR11426:SF20
organism: Strongylocentrotus purpuratus

PTHR45810:SF10
type: RelationshipXref
id: PTHR45810:SF10
db: PANTHER Family
relationship type: By Homology

P00536
type: UnificationXref
id: P00536
db: PANTHER Pathway Component

P00537
type: UnificationXref
id: P00537
db: PANTHER Pathway Component

P00538
type: UnificationXref
id: P00538
db: PANTHER Pathway Component

P00532
type: UnificationXref
id: P00532
db: PANTHER Pathway Component

ncbitaxon 10116 9
type: UnificationXref
id: 10116
db: ncbitaxon

P00533
type: UnificationXref
id: P00533
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dsDNA-_n_H2O-RIGHT__n_NMP-_dsDNA-_r68
controller: 5'->3' Exoribonulcease

P00534
type: UnificationXref
id: P00534
db: PANTHER Pathway Component

uniprot H2QJX3 243
type: UnificationXref
id: H2QJX3
db: uniprot

uniprot P33610 12
type: UnificationXref
id: P33610
db: uniprot

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 53

Replication factor C subunit 5
type: ProteinReference
xref: uniprot P40937 169
organism: Homo sapiens

Replication factor C subunit 3
type: ProteinReference
xref: uniprot P40938 170
organism: Homo sapiens

uniprot Q38EZ6 195
type: UnificationXref
id: Q38EZ6
db: uniprot

uniprot W4ZHT8 161
type: UnificationXref
id: W4ZHT8
db: uniprot

DNA polymerase subunit delta-2
type: ProteinReference
xref: uniprot P87324 232
xref: PTHR10416:SF0
organism: Schizosaccharomyces pombe

ncbitaxon 284812 104
type: UnificationXref
id: 284812
db: ncbitaxon

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 281

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 4

uniprot P12004 245
type: UnificationXref
id: P12004
db: uniprot

STATE_TRANSITION_LEFT__dsDNA-_n_H2O-RIGHT__n_NMP-_dsDNA-_r68
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 391
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 392
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 390
participant stoichiometry: PARTICIPANT STOICHIOMETRY r68 389
left: n H2O
left: dsDNA
interaction type: STATE_TRANSITION
right: n NMP
right: dsDNA

Replication protein A2, 32kDa
type: ProteinReference
xref: PTHR13989:SF10
xref: uniprot Q2KI86 287
organism: Bos taurus

DNA topoisomerase 2
type: ProteinReference
xref: uniprot F1PRA7 267
organism: Canis lupus familiaris

Histone H3
type: ProteinReference
xref: uniprot E3JR96 63
xref: PTHR11426:SF47
organism: Puccinia graminis

eco ECO:0000303 219
type: UnificationXref
id: ECO:0000303
db: eco

PARTICIPANT STOICHIOMETRY re10 402
type: Stoichiometry
physical entity: ATPs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 403
type: Stoichiometry
physical entity: dsDNA-primase complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 404
type: Stoichiometry
physical entity: RFC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 405
type: Stoichiometry
physical entity: ADPs + Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 406
type: Stoichiometry
physical entity: dsDNA-primase-RFC complex
stoichiometric coefficient: 1.0

Primase s4 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Primase
stoichiometric coefficient: 1.0

ATP-dependent DNA helicase Q-like 4B
type: ProteinReference
xref: PTHR13710:SF132
xref: uniprot Q9FT70 215
organism: Arabidopsis thaliana

uniprot A9UTW8 38
type: UnificationXref
id: A9UTW8
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 74

ssDNA s97 a88 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ssDNA
stoichiometric coefficient: 2.0

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 80

uniprot P17918 247
type: UnificationXref
id: P17918
db: uniprot

Complex (Pol alpha/Primase)
type: Complex
component stoichiometry: Pol alpha s79 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: Primase s80 sa11 STOICHIOMETRY ID COMPLEX
component: Pol alpha
component: Primase
feature: COMPLEX BINDING FEATURE s78 a203 306
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 a203 311
feature: COMPLEX BINDING FEATURE s78 a203 308

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 209

Histone H3
type: ProteinReference
xref: PTHR11426:SF236
xref: uniprot F7AHT0 79
organism: Ciona intestinalis

PTHR10536:SF0
type: RelationshipXref
id: PTHR10536:SF0
db: PANTHER Family
relationship type: By Homology

uniprot P35251 167
type: UnificationXref
id: P35251
db: uniprot

uniprot B7P7T4 46
type: UnificationXref
id: B7P7T4
db: uniprot

eco ECO:0000270 209
type: UnificationXref
id: ECO:0000270
db: eco

Histone H3
type: ProteinReference
xref: uniprot E3JT42 65
xref: PTHR11426:SF47
organism: Puccinia graminis

dsDNA
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 a99 371
comment: SPECIES_TYPE=GENE

uniprot P08096 275
type: UnificationXref
id: P08096
db: uniprot

uniprot Q6RCM0 280
type: UnificationXref
id: Q6RCM0
db: uniprot

DNA topoisomerase 2
type: ProteinReference
xref: uniprot F7FGH6 269
organism: Ornithorhynchus anatinus

Primase s80 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Primase
stoichiometric coefficient: 1.0

nPPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

n dNTP + Mg++
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

dsDNA s72 a132 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 1.0

Pol alpha s69 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pol alpha
stoichiometric coefficient: 1.0

Proliferating cell nuclear antigen
type: ProteinReference
xref: uniprot P12004 245
xref: PTHR11352:SF5
organism: Homo sapiens

uniprot Q4P7J7 130
type: UnificationXref
id: Q4P7J7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot W4YZJ8 157
xref: PTHR11426:SF20
organism: Strongylocentrotus purpuratus

Uncharacterized protein
type: ProteinReference
xref: PTHR11426:SF101
xref: uniprot W4Y7N6 154
organism: Strongylocentrotus purpuratus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GJR4 291
xref: PTHR10642:SF23
organism: Macaca mulatta

uniprot Q7PUQ8 142
type: UnificationXref
id: Q7PUQ8
db: uniprot

uniprot P04786 184
type: UnificationXref
id: P04786
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot F7AME5 81
xref: PTHR11426:SF20
organism: Ornithorhynchus anatinus

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 251

Ribonuclease H1
type: ProteinReference
xref: uniprot O60930 293
xref: PTHR10642:SF23
organism: Homo sapiens

uniprot F6TK66 77
type: UnificationXref
id: F6TK66
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 111

Histones
type: ProteinReference
xref: P00527
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.Histones
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Histones Synonym: Synonym not specified Accession: P00527
member entity reference: Histone H3
member entity reference: Predicted protein
member entity reference: Histone H3.3C
member entity reference: Histone H3 (Fragment)
member entity reference: Histone H3.3
member entity reference: Histone H3-like 1
member entity reference: Histone H3, embryonic
member entity reference: Uncharacterized protein
member entity reference: Histone H3.1
member entity reference: Histone H3.3-like type 2
member entity reference: Histone H3.3 type 1
member entity reference: Histone H3.1t
member entity reference: Histone H3.3 type 2
member entity reference: Histone H3-like 3
member entity reference: Histone H3.2
member entity reference: Histone H3.1/H3.2

DNA topoisomerase I
type: ProteinReference
xref: uniprot H2QKC9 180
organism: Pan troglodytes

uniprot B3RZQ5 43
type: UnificationXref
id: B3RZQ5
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot F7CMG6 85
xref: PTHR11426:SF203
organism: Ornithorhynchus anatinus

DNA polymerase delta catalytic subunit
type: ProteinReference
xref: uniprot P28340 225
xref: PTHR10322:SF23
organism: Homo sapiens

Histone H3
type: ProteinReference
xref: uniprot G3MYD7 91
xref: PTHR11426:SF228
organism: Bos taurus

Danio rerio
type: BioSource
xref: ncbitaxon 7955 34

uniprot Q2KI86 287
type: UnificationXref
id: Q2KI86
db: uniprot

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 296

Histone H3.3
type: ProteinReference
xref: uniprot P59169 110
xref: PTHR11426:SF210
organism: Arabidopsis thaliana

uniprot F1MDU7 264
type: UnificationXref
id: F1MDU7
db: uniprot

uniprot O42131 273
type: UnificationXref
id: O42131
db: uniprot

uniprot Q9LRE6 238
type: UnificationXref
id: Q9LRE6
db: uniprot

uniprot P61074 248
type: UnificationXref
id: P61074
db: uniprot

Histone H3
type: ProteinReference
xref: PTHR11426:SF20
xref: uniprot A7TAJ3 28
organism: Nematostella vectensis

RPA
type: Protein
entity reference: RPA
feature: COMPLEX PARTICIPANT BINDING FEATURE s83 a140 321
comment: SPECIES_TYPE=PROTEIN

Replication factor C subunit 5
type: ProteinReference
xref: uniprot Q9D0F6 176
organism: Mus musculus

uniprot D3ZJ08 60
type: UnificationXref
id: D3ZJ08
db: uniprot

uniprot Q99J62 175
type: UnificationXref
id: Q99J62
db: uniprot

uniprot Q641W4 172
type: UnificationXref
id: Q641W4
db: uniprot

DNA topoisomerase I, mitochondrial
type: ProteinReference
xref: uniprot Q6IM78 279
organism: Rattus norvegicus

uniprot A7T7J5 26
type: UnificationXref
id: A7T7J5
db: uniprot

Histone H3
type: ProteinReference
xref: PTHR11426:SF101
xref: uniprot B5YMD6 44
organism: Thalassiosira pseudonana

uniprot Q16695 127
type: UnificationXref
id: Q16695
db: uniprot

uniprot Q8TSB3 236
type: UnificationXref
id: Q8TSB3
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot W4XW29 150
xref: PTHR11426:SF20
organism: Strongylocentrotus purpuratus

PARTICIPANT STOICHIOMETRY r1 394
type: Stoichiometry
physical entity: Chromatin (DNA + Histones + Other Proteins) Replication_Competant_State
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 393
type: Stoichiometry
physical entity: Chromatin (DNA + Histones + Other Proteins)
stoichiometric coefficient: 1.0

Hel
type: Protein
entity reference: Hel
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 a161 353
comment: SPECIES_TYPE=PROTEIN

Histone H3.3 type 1
type: ProteinReference
xref: PTHR11426:SF236
xref: uniprot Q10453 126
organism: Caenorhabditis elegans

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 131

ncbitaxon 6945 47
type: UnificationXref
id: 6945
db: ncbitaxon

RPA
type: Protein
entity reference: RPA
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 a188 359
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9031 121
type: UnificationXref
id: 9031
db: ncbitaxon

PTHR13989:SF41
type: RelationshipXref
id: PTHR13989:SF41
db: PANTHER Family
relationship type: By Homology

Histone H3
type: ProteinReference
xref: uniprot F7F5J0 87
xref: PTHR11426:SF201
organism: Ornithorhynchus anatinus

uniprot Q4QF53 197
type: UnificationXref
id: Q4QF53
db: uniprot

uniprot K7BYJ3 182
type: UnificationXref
id: K7BYJ3
db: uniprot

Complex (Pol alpha/Primase)
type: Complex
component stoichiometry: Pol alpha s91 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Primase s92 sa4 STOICHIOMETRY ID COMPLEX
component: Primase
component: Pol alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 a193 381
feature: COMPLEX BINDING FEATURE s90 a193 336
feature: COMPLEX BINDING FEATURE s90 a193 334

uniprot F7F5J0 87
type: UnificationXref
id: F7F5J0
db: uniprot

uniprot R4GM79 284
type: UnificationXref
id: R4GM79
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot E3KAH9 67
xref: PTHR11426:SF47
organism: Puccinia graminis

Histone H3
type: ProteinReference
xref: uniprot B3RZQ5 43
xref: PTHR11426:SF236
organism: Trichoplax adhaerens

Histone H3.2
type: ProteinReference
xref: PTHR11426:SF217
xref: uniprot Q2RAD9 129
organism: Oryza sativa

Histone H3
type: ProteinReference
xref: uniprot A7T8N3 27
xref: PTHR11426:SF101
organism: Nematostella vectensis

ncbitaxon 243232 251
type: UnificationXref
id: 243232
db: ncbitaxon

uniprot P40938 170
type: UnificationXref
id: P40938
db: uniprot

uniprot Q57XA9 299
type: UnificationXref
id: Q57XA9
db: uniprot

uniprot Q0JCT1 122
type: UnificationXref
id: Q0JCT1
db: uniprot

uniprot W4XAB3 147
type: UnificationXref
id: W4XAB3
db: uniprot

PTHR13989:SF16
type: RelationshipXref
id: PTHR13989:SF16
db: PANTHER Family
relationship type: By Homology

PTHR11426:SF190
type: RelationshipXref
id: PTHR11426:SF190
db: PANTHER Family
relationship type: By Homology

PTHR11426:SF192
type: RelationshipXref
id: PTHR11426:SF192
db: PANTHER Family
relationship type: By Homology

uniprot H3IYA6 96
type: UnificationXref
id: H3IYA6
db: uniprot

Pol alpha s79 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pol alpha
stoichiometric coefficient: 1.0

Predicted protein
type: ProteinReference
xref: PTHR11426:SF232
xref: uniprot A7SEB4 23
organism: Nematostella vectensis

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 9

PTHR10954:SF7
type: RelationshipXref
id: PTHR10954:SF7
db: PANTHER Family
relationship type: By Homology

DNA topoisomerase 2
type: ProteinReference
xref: uniprot F7EVK2 179
organism: Macaca mulatta

uniprot W4XWM4 151
type: UnificationXref
id: W4XWM4
db: uniprot

uniprot P68432 113
type: UnificationXref
id: P68432
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot A9UZD4 40
xref: PTHR11426:SF101
organism: Monosiga brevicollis

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 70

ncbitaxon 6239 102
type: UnificationXref
id: 6239
db: ncbitaxon

DNA polymerase
type: ProteinReference
xref: uniprot Q8TSB3 236
xref: PTHR10322:SF23
organism: Methanosarcina acetivorans

Histone H3
type: ProteinReference
xref: PTHR11426:SF232
xref: uniprot F7C8E5 84
organism: Monodelphis domestica

Pol delta
type: Protein
entity reference: Pol delta
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa7 343
comment: SPECIES_TYPE=PROTEIN

DNA topoisomerase 1 alpha
type: ProteinReference
xref: uniprot P30181 276
organism: Arabidopsis thaliana

Histone H3
type: ProteinReference
xref: uniprot A8XPY9 37
xref: PTHR11426:SF236
organism: Caenorhabditis briggsae

DNA topoisomerase 2
type: ProteinReference
xref: uniprot P30182 277
organism: Arabidopsis thaliana

uniprot Q8ZXL6 301
type: UnificationXref
id: Q8ZXL6
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot A8KBJ5 33
xref: PTHR11426:SF101
organism: Danio rerio

Histone H3
type: ProteinReference
xref: PTHR11426:SF232
xref: uniprot B7PAJ2 48
organism: Ixodes scapularis

DNA topoisomerase 1
type: ProteinReference
xref: uniprot P30189 190
organism: Drosophila melanogaster

uniprot Q5ADQ0 135
type: UnificationXref
id: Q5ADQ0
db: uniprot

Histone H3.3C
type: ProteinReference
xref: uniprot Q6NXT2 138
xref: PTHR11426:SF228
organism: Homo sapiens

ADPs + Pi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P84245 119
type: UnificationXref
id: P84245
db: uniprot

uniprot Q9WUK4 177
type: UnificationXref
id: Q9WUK4
db: uniprot

uniprot Q8TUF7 256
type: UnificationXref
id: Q8TUF7
db: uniprot

uniprot F7EYD7 285
type: UnificationXref
id: F7EYD7
db: uniprot

DNA topoisomerase 2
type: ProteinReference
xref: uniprot J9PAY8 270
organism: Canis lupus familiaris

ncbitaxon 367110 100
type: UnificationXref
id: 367110
db: ncbitaxon

Histone H3
type: ProteinReference
xref: uniprot A7TCQ6 29
xref: PTHR11426:SF20
organism: Nematostella vectensis

Histone H3
type: ProteinReference
xref: uniprot W4XZV8 152
xref: PTHR11426:SF20
organism: Strongylocentrotus purpuratus

Replication factor C subunit 2
type: ProteinReference
xref: uniprot Q9WUK4 177
organism: Mus musculus

Replication factor C subunit 4
type: ProteinReference
xref: uniprot P35249 165
organism: Homo sapiens

uniprot Q5KMT3 137
type: UnificationXref
id: Q5KMT3
db: uniprot

ssDNA
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 a88 367
comment: SPECIES_TYPE=GENE

uniprot Q7KQJ9 255
type: UnificationXref
id: Q7KQJ9
db: uniprot

uniprot P35249 165
type: UnificationXref
id: P35249
db: uniprot

Pol alpha
type: Protein
entity reference: Pol alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa10 307
comment: SPECIES_TYPE=PROTEIN

uniprot Q8R4U6 282
type: UnificationXref
id: Q8R4U6
db: uniprot

uniprot A7TCQ6 29
type: UnificationXref
id: A7TCQ6
db: uniprot

ncbitaxon 10090 11
type: UnificationXref
id: 10090
db: ncbitaxon

PTHR13989:SF10
type: RelationshipXref
id: PTHR13989:SF10
db: PANTHER Family
relationship type: By Homology

DNA topoisomerase 1
type: ProteinReference
xref: uniprot Q9WUL0 200
organism: Rattus norvegicus

Replication factor C subunit 2
type: ProteinReference
xref: uniprot P35250 166
organism: Homo sapiens

Replication factor C subunit 1
type: ProteinReference
xref: uniprot P35251 167
organism: Homo sapiens

uniprot Q27532 128
type: UnificationXref
id: Q27532
db: uniprot

uniprot A7EW99 19
type: UnificationXref
id: A7EW99
db: uniprot

uniprot Q8ZYL6 259
type: UnificationXref
id: Q8ZYL6
db: uniprot

Proliferating cell nuclear antigen
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot P17918 247
organism: Mus musculus

DNA polymerase delta catalytic subunit
type: ProteinReference
xref: PTHR10322:SF23
xref: uniprot O54747 223
organism: Rattus norvegicus

ssDNA s102 a105 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ssDNA
stoichiometric coefficient: 2.0

DNA polymerase
type: ProteinReference
xref: uniprot Q9U0H1 210
xref: PTHR45861:SF1
organism: Plasmodium falciparum

uniprot Q0UY45 124
type: UnificationXref
id: Q0UY45
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot F7BRX2 83
xref: PTHR11426:SF204
organism: Macaca mulatta

uniprot A8HSA7 30
type: UnificationXref
id: A8HSA7
db: uniprot

PTHR45861:SF1
type: RelationshipXref
id: PTHR45861:SF1
db: PANTHER Family
relationship type: By Homology

DNA topoisomerase 1 beta
type: ProteinReference
xref: uniprot Q9FJ79 283
organism: Arabidopsis thaliana

uniprot O70338 294
type: UnificationXref
id: O70338
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot W4XZX1 153
xref: PTHR11426:SF20
organism: Strongylocentrotus purpuratus

uniprot F6XLZ2 78
type: UnificationXref
id: F6XLZ2
db: uniprot

ncbitaxon 45351 22
type: UnificationXref
id: 45351
db: ncbitaxon

uniprot Q4PB04 132
type: UnificationXref
id: Q4PB04
db: uniprot

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot P35601 168
type: UnificationXref
id: P35601
db: uniprot

DNA polymerase delta catalytic subunit
type: ProteinReference
xref: uniprot P52431 230
xref: PTHR10322:SF23
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dsDNA-_Histones-_ATP-RIGHT__ADP__PLUS__Pi-_Chromatin__DNA__PLUS__Histones__PLUS__Other_Proteins_-_r69
controller: DNA Topisomerase

PARTICIPANT STOICHIOMETRY re11 398
type: Stoichiometry
physical entity: Complex (Pol alpha/Primase)
stoichiometric coefficient: 1.0

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 109

PARTICIPANT STOICHIOMETRY re11 397
type: Stoichiometry
physical entity: ATPs
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 399
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 1.0

ncbitaxon 178306 258
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot F7C8E5 84
type: UnificationXref
id: F7C8E5
db: uniprot

uniprot W4XKA2 149
type: UnificationXref
id: W4XKA2
db: uniprot

DNA polymerase sliding clamp
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot Q8TUF7 256
organism: Methanosarcina acetivorans

uniprot A7SVW3 24
type: UnificationXref
id: A7SVW3
db: uniprot

uniprot Q9LR02 145
type: UnificationXref
id: Q9LR02
db: uniprot

DNA polymerase alpha catalytic subunit
type: ProteinReference
xref: uniprot P33609 206
xref: PTHR45861:SF1
organism: Mus musculus

PCNA s5 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PCNA
stoichiometric coefficient: 1.0

DNA primase large subunit
type: ProteinReference
xref: PTHR10537:SF3
xref: uniprot P33610 12
organism: Mus musculus

uniprot Q9FKQ3 143
type: UnificationXref
id: Q9FKQ3
db: uniprot

uniprot F7FGH6 269
type: UnificationXref
id: F7FGH6
db: uniprot

uniprot Q6K9U2 289
type: UnificationXref
id: Q6K9U2
db: uniprot

PTHR11426:SF118
type: RelationshipXref
id: PTHR11426:SF118
db: PANTHER Family
relationship type: By Homology

eco ECO:0000250 4
type: UnificationXref
id: ECO:0000250
db: eco

eco ECO:0000353 229
type: UnificationXref
id: ECO:0000353
db: eco

ncbitaxon 9913 3
type: UnificationXref
id: 9913
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r69 385
type: Stoichiometry
physical entity: Histones
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 384
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 1.0

Complex PCNA RFC Pol delta s58 a199 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (PCNA/RFC/ Pol delta)
stoichiometric coefficient: 1.0

uniprot F7E5A9 178
type: UnificationXref
id: F7E5A9
db: uniprot

PARTICIPANT STOICHIOMETRY r69 388
type: Stoichiometry
physical entity: Chromatin (DNA + Histones + Other Proteins)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r69 387
type: Stoichiometry
physical entity: ADP + Pi
stoichiometric coefficient: 1.0

PTHR10537:SF3
type: RelationshipXref
id: PTHR10537:SF3
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r69 386
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 185

RPA
type: Protein
entity reference: RPA
feature: COMPLEX PARTICIPANT BINDING FEATURE s103 a106 377
comment: SPECIES_TYPE=PROTEIN

uniprot W4YZJ8 157
type: UnificationXref
id: W4YZJ8
db: uniprot

uniprot Q7KQL4 235
type: UnificationXref
id: Q7KQL4
db: uniprot

Replication protein A 32 kDa subunit
type: ProteinReference
xref: PTHR13989:SF10
xref: uniprot F7EYD7 285
organism: Macaca mulatta

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 51

uniprot E3JR96 63
type: UnificationXref
id: E3JR96
db: uniprot

Proliferating cell nuclear antigen
type: ProteinReference
xref: uniprot F6ZD63 242
xref: PTHR11352:SF5
organism: Macaca mulatta

PTHR11426:SF47
type: RelationshipXref
id: PTHR11426:SF47
db: PANTHER Family
relationship type: By Homology

uniprot Q66KJ8 254
type: UnificationXref
id: Q66KJ8
db: uniprot

uniprot F7BRX2 83
type: UnificationXref
id: F7BRX2
db: uniprot

uniprot P49642 13
type: UnificationXref
id: P49642
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot H3IYA6 96
xref: PTHR11426:SF236
organism: Strongylocentrotus purpuratus

DNA polymerase sliding clamp 1
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot Q8ZTY0 257
organism: Pyrobaculum aerophilum

Hel
type: ProteinReference
xref: P00532
standard name: Helicase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Helicase Synonym: Helicase Accession: P00532
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.Hel
member entity reference: DNA replication ATP-dependent helicase/nuclease DNA2
member entity reference: ATP-dependent DNA helicase Q-like 4B
member entity reference: DNA replication helicase/nuclease 2

Histone H3-like 3
type: ProteinReference
xref: uniprot Q9LR02 145
xref: PTHR11426:SF210
organism: Arabidopsis thaliana

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 58

uniprot F6PGA3 73
type: UnificationXref
id: F6PGA3
db: uniprot

Hel s96 a74 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hel
stoichiometric coefficient: 2.0

PTHR11426:SF44
type: RelationshipXref
id: PTHR11426:SF44
db: PANTHER Family
relationship type: By Homology

Thermococcus kodakaraensis
type: BioSource
xref: ncbitaxon 69014 253

Hel s101 a103 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Hel
stoichiometric coefficient: 2.0

Proliferating cell nuclear antigen
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot P17070 246
organism: Oryza sativa

uniprot P49004 227
type: UnificationXref
id: P49004
db: uniprot

Pol delta s7 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pol delta
stoichiometric coefficient: 1.0

ncbitaxon 559292 185
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot F1MU48 266
type: UnificationXref
id: F1MU48
db: uniprot

Histone H3.3
type: ProteinReference
xref: uniprot P10651 107
xref: PTHR11426:SF101
organism: Schizosaccharomyces pombe

ncbitaxon 8364 204
type: UnificationXref
id: 8364
db: ncbitaxon

RPA
type: Protein
entity reference: RPA
comment: SPECIES_TYPE=PROTEIN

Histones
type: Protein
entity reference: Histones
comment: SPECIES_TYPE=PROTEIN

DNA topoisomerase 1
type: ProteinReference
xref: uniprot P07799 274
organism: Schizosaccharomyces pombe

DNA polymerase delta small subunit, putative
type: ProteinReference
xref: uniprot O77321 224
xref: PTHR10416:SF0
organism: Plasmodium falciparum

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 204

uniprot P17070 246
type: UnificationXref
id: P17070
db: uniprot

uniprot P02299 97
type: UnificationXref
id: P02299
db: uniprot

Proliferating cell nuclear antigen
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot F6TIM3 241
organism: Monodelphis domestica

uniprot H2R0Q8 6
type: UnificationXref
id: H2R0Q8
db: uniprot

uniprot Q9HNR3 302
type: UnificationXref
id: Q9HNR3
db: uniprot

uniprot P59226 112
type: UnificationXref
id: P59226
db: uniprot

Proliferating cell nuclear antigen
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot P61074 248
organism: Plasmodium falciparum

Hel
type: Protein
entity reference: Hel
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 a74 365
comment: SPECIES_TYPE=PROTEIN

uniprot O35654 222
type: UnificationXref
id: O35654
db: uniprot

DNA topoisomerase 2
type: ProteinReference
xref: uniprot K7CLW1 183
organism: Pan troglodytes

Ribonuclease H1
type: ProteinReference
xref: uniprot H2QHD3 292
xref: PTHR10642:SF23
organism: Pan troglodytes

uniprot F7AHT0 79
type: UnificationXref
id: F7AHT0
db: uniprot

uniprot F6Z608 203
type: UnificationXref
id: F6Z608
db: uniprot

RNA exonuclease 1
type: ProteinReference
xref: uniprot P53331 297
organism: Saccharomyces cerevisiae

uniprot Q01320 192
type: UnificationXref
id: Q01320
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot H3I1F0 94
xref: PTHR11426:SF101
organism: Strongylocentrotus purpuratus

uniprot P41516 191
type: UnificationXref
id: P41516
db: uniprot

DNA replication ATP-dependent helicase/nuclease DNA2
type: ProteinReference
xref: uniprot D3ZG52 212
organism: Rattus norvegicus

Replication factor C subunit 1
type: ProteinReference
xref: uniprot D3ZFT1 164
organism: Rattus norvegicus

ncbitaxon 7668 95
type: UnificationXref
id: 7668
db: ncbitaxon

ncbitaxon 36329 58
type: UnificationXref
id: 36329
db: ncbitaxon

ssDNA
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 a139 319
comment: SPECIES_TYPE=GENE

uniprot P06352 98
type: UnificationXref
id: P06352
db: uniprot

ncbitaxon 418459 64
type: UnificationXref
id: 418459
db: ncbitaxon

Ribonuclease H1
type: ProteinReference
xref: uniprot O70338 294
xref: PTHR10642:SF23
organism: Mus musculus

uniprot W4XJN4 148
type: UnificationXref
id: W4XJN4
db: uniprot

uniprot P07799 274
type: UnificationXref
id: P07799
db: uniprot

Replication factor C subunit 2
type: ProteinReference
xref: uniprot Q641W4 172
organism: Rattus norvegicus

Replication factor C (Activator 1) 3
type: ProteinReference
xref: uniprot Q5M830 171
organism: Rattus norvegicus

Histone H3.3C
type: ProteinReference
xref: uniprot A5PK61 18
xref: PTHR11426:SF228
organism: Bos taurus

Replication factor C subunit 1
type: ProteinReference
xref: uniprot P35601 168
organism: Mus musculus

uniprot Q9FT70 215
type: UnificationXref
id: Q9FT70
db: uniprot

Proliferating cell nuclear antigen
type: ProteinReference
xref: uniprot P04961 244
xref: PTHR11352:SF0
organism: Rattus norvegicus

uniprot Q04740 298
type: UnificationXref
id: Q04740
db: uniprot

DNA primase small subunit PriS
type: ProteinReference
xref: uniprot Q8TSZ5 15
xref: PTHR10536:SF0
organism: Methanosarcina acetivorans

Histone H3.3-like type 2
type: ProteinReference
xref: PTHR11426:SF118
xref: uniprot Q27532 128
organism: Caenorhabditis elegans

uniprot Q02880 193
type: UnificationXref
id: Q02880
db: uniprot

Top s66 a163 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Top
stoichiometric coefficient: 1.0

uniprot Q8TU09 174
type: UnificationXref
id: Q8TU09
db: uniprot

RPA s83 a140 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RPA
stoichiometric coefficient: 3.0

Histone H3.1
type: ProteinReference
xref: PTHR11426:SF232
xref: uniprot P68432 113
organism: Bos taurus

Histone H3.1
type: ProteinReference
xref: uniprot P68433 114
xref: PTHR11426:SF232
organism: Mus musculus

ssDNA s63 a157 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ssDNA
stoichiometric coefficient: 2.0

Top
type: Protein
entity reference: Top
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 a163 357
comment: SPECIES_TYPE=PROTEIN

Ribonuclease HI
type: ProteinReference
xref: uniprot P0A7Y4 295
xref: PTHR10642:SF23
organism: Escherichia coli

uniprot F7EVK2 179
type: UnificationXref
id: F7EVK2
db: uniprot

DNA topoisomerase I
type: ProteinReference
xref: uniprot F1MN93 265
organism: Bos taurus

Histone H3
type: ProteinReference
xref: uniprot P0CO04 105
xref: PTHR11426:SF101
organism: Cryptococcus neoformans

DNA topoisomerase 2
type: ProteinReference
xref: uniprot P08096 275
organism: Schizosaccharomyces pombe

DNA replication ATP-dependent helicase/nuclease DNA2
type: ProteinReference
xref: uniprot P51530 213
organism: Homo sapiens

DNA topoisomerase 2
type: ProteinReference
xref: uniprot K7BYJ3 182
organism: Pan troglodytes

uniprot W4YRY4 156
type: UnificationXref
id: W4YRY4
db: uniprot

STATE_TRANSITION_LEFT__dsDNA_replication_complex-RIGHT__dsDNA-_r67
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 395
participant stoichiometry: PARTICIPANT STOICHIOMETRY r67 396
left: dsDNA-replication complex
interaction type: STATE_TRANSITION
right: dsDNA

Uncharacterized protein
type: ProteinReference
xref: PTHR11426:SF228
xref: uniprot F6XLZ2 78
organism: Macaca mulatta

uniprot O17966 271
type: UnificationXref
id: O17966
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 3

Replication factor A protein 2
type: ProteinReference
xref: PTHR13989:SF16
xref: uniprot Q92373 290
organism: Schizosaccharomyces pombe

nascent DNA
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s62 a153 349
comment: SPECIES_TYPE=GENE

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 82

nascent DNA s39 a147 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: nascent DNA
stoichiometric coefficient: 1.0

DNA primase large subunit
type: ProteinReference
xref: uniprot O89044 8
xref: PTHR10537:SF3
organism: Rattus norvegicus

uniprot A9UZD4 40
type: UnificationXref
id: A9UZD4
db: uniprot

uniprot W4XZX1 153
type: UnificationXref
id: W4XZX1
db: uniprot

Pol delta
type: ProteinReference
xref: P00533
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Pol delta Synonym: Synonym not specified Accession: P00533
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.Pol _delta_
member entity reference: DNA polymerase delta subunit 2
member entity reference: DNA polymerase delta catalytic subunit
member entity reference: DNA polymerase
member entity reference: DNA polymerase delta small subunit, putative
member entity reference: DNA polymerase delta 2, accessory subunit
member entity reference: DNA polymerase subunit delta-2
member entity reference: Polymerase (DNA directed), delta 2, regulatory subunit
member entity reference: DNA polymerase delta small subunit

Top
type: Protein
entity reference: Top
feature: COMPLEX PARTICIPANT BINDING FEATURE s104 a98 379
comment: SPECIES_TYPE=PROTEIN

Histone H3
type: ProteinReference
xref: PTHR11426:SF190
xref: uniprot A8HSA7 30
organism: Chlamydomonas reinhardtii

Histone H3
type: ProteinReference
xref: PTHR11426:SF232
xref: uniprot C3YMG9 55
organism: Branchiostoma floridae

RFC
type: Protein
entity reference: RFC
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000304 216
type: UnificationXref
id: ECO:0000304
db: eco

dsDNA s99 csa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 1.0

uniprot A7SX94 25
type: UnificationXref
id: A7SX94
db: uniprot

uniprot F1LRJ6 202
type: UnificationXref
id: F1LRJ6
db: uniprot

uniprot Q6PI20 139
type: UnificationXref
id: Q6PI20
db: uniprot

Predicted protein
type: ProteinReference
xref: PTHR11426:SF218
xref: uniprot A7SVW3 24
organism: Nematostella vectensis

RPA s67 a188 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RPA
stoichiometric coefficient: 3.0

RFC
type: Protein
entity reference: RFC
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa6 341
comment: SPECIES_TYPE=PROTEIN

uniprot Q504I6 288
type: UnificationXref
id: Q504I6
db: uniprot

ncbitaxon 7227 51
type: UnificationXref
id: 7227
db: ncbitaxon

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 47

DNA topoisomerase 2
type: ProteinReference
xref: uniprot F7E5A9 178
organism: Macaca mulatta

DNA primase small subunit
type: ProteinReference
xref: uniprot P49642 13
xref: PTHR10536:SF0
organism: Homo sapiens

uniprot D3ZG52 212
type: UnificationXref
id: D3ZG52
db: uniprot

uniprot W4Y7N6 154
type: UnificationXref
id: W4Y7N6
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot F4P7A5 71
xref: PTHR11426:SF101
organism: Batrachochytrium dendrobatidis

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 240

Pol alpha s91 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pol alpha
stoichiometric coefficient: 1.0

Histone H3
type: ProteinReference
xref: PTHR11426:SF232
xref: uniprot P08898 101
organism: Caenorhabditis elegans

Histone H3
type: ProteinReference
xref: uniprot D3ZK97 61
xref: PTHR11426:SF44
organism: Rattus norvegicus

RFC s77 a151 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RFC
stoichiometric coefficient: 1.0

uniprot F7D0D3 268
type: UnificationXref
id: F7D0D3
db: uniprot

DNA topoisomerase I
type: ProteinReference
xref: uniprot R4GM79 284
organism: Gallus gallus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 121

Predicted protein
type: ProteinReference
xref: PTHR11426:SF192
xref: uniprot A7RJG4 21
organism: Nematostella vectensis

DNA replication ATP-dependent helicase/nuclease DNA2
type: ProteinReference
xref: uniprot Q6ZQJ5 214
organism: Mus musculus

Pol alpha s3 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Pol alpha
stoichiometric coefficient: 1.0

Histone H3.1/H3.2
type: ProteinReference
xref: uniprot P09988 103
xref: PTHR11426:SF101
organism: Schizosaccharomyces pombe

Complex Pol alpha Primase s78 a203 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (Pol alpha/Primase)
stoichiometric coefficient: 1.0

uniprot A0A2I3RGW0 211
type: UnificationXref
id: A0A2I3RGW0
db: uniprot

PTHR11352:SF0
type: RelationshipXref
id: PTHR11352:SF0
db: PANTHER Family
relationship type: By Homology

dsDNA
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 a162 355
comment: SPECIES_TYPE=GENE

ncbitaxon 227321 109
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot C6KSV0 57
type: UnificationXref
id: C6KSV0
db: uniprot

uniprot Q6IM78 279
type: UnificationXref
id: Q6IM78
db: uniprot

uniprot F7F1M9 86
type: UnificationXref
id: F7F1M9
db: uniprot

DNA topoisomerase 2
type: ProteinReference
xref: uniprot F7D0D3 268
organism: Monodelphis domestica

Histone H3.3
type: ProteinReference
xref: uniprot Q0JCT1 122
xref: PTHR11426:SF231
organism: Oryza sativa

Histone H3
type: ProteinReference
xref: PTHR11426:SF236
xref: uniprot B7P7T4 46
organism: Ixodes scapularis

DNA topoisomerase 1
type: ProteinReference
xref: uniprot P04786 184
organism: Saccharomyces cerevisiae

Histone H3
type: ProteinReference
xref: PTHR11426:SF214
xref: uniprot W4XAB3 147
organism: Strongylocentrotus purpuratus

uniprot F6TIM3 241
type: UnificationXref
id: F6TIM3
db: uniprot

ncbitaxon 9598 7
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot Q04750 194
type: UnificationXref
id: Q04750
db: uniprot

uniprot Q9FX60 144
type: UnificationXref
id: Q9FX60
db: uniprot

uniprot P11388 188
type: UnificationXref
id: P11388
db: uniprot

PTHR11352:SF5
type: RelationshipXref
id: PTHR11352:SF5
db: PANTHER Family
relationship type: By Homology

Histone H3
type: ProteinReference
xref: uniprot A9UTW8 38
xref: PTHR11426:SF236
organism: Monosiga brevicollis

uniprot P28340 225
type: UnificationXref
id: P28340
db: uniprot

ncbitaxon 5759 281
type: UnificationXref
id: 5759
db: ncbitaxon

Complex Pol alpha Primase s90 a193 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (Pol alpha/Primase)
stoichiometric coefficient: 1.0

PTHR11426:SF20
type: RelationshipXref
id: PTHR11426:SF20
db: PANTHER Family
relationship type: By Homology

uniprot F1MN93 265
type: UnificationXref
id: F1MN93
db: uniprot

uniprot P09884 205
type: UnificationXref
id: P09884
db: uniprot

PCNA
type: Protein
entity reference: PCNA
comment: SPECIES_TYPE=PROTEIN

Ribonuclease HII
type: ProteinReference
xref: PTHR10954:SF7
xref: uniprot Q8ZXL6 301
organism: Pyrobaculum aerophilum

Top
type: ProteinReference
xref: P00530
standard name: Topoisomerase
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.Top
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Topoisomerase Synonym: Synonym not specified Accession: P00530
member entity reference: DNA topoisomerase I
member entity reference: DNA topoisomerase 2
member entity reference: DNA topoisomerase 2-alpha
member entity reference: DNA topoisomerase 2-beta
member entity reference: DNA topoisomerase 1

uniprot P51530 213
type: UnificationXref
id: P51530
db: uniprot

uniprot P09988 103
type: UnificationXref
id: P09988
db: uniprot

ssDNA
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s102 a105 375
comment: SPECIES_TYPE=GENE

dsDNA
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 a132 313
comment: SPECIES_TYPE=GENE

Proliferating cell nuclear antigen
type: ProteinReference
xref: uniprot H2QJX3 243
xref: PTHR11352:SF5
organism: Pan troglodytes

uniprot Q9DEA3 260
type: UnificationXref
id: Q9DEA3
db: uniprot

uniprot Q3ZBW4 249
type: UnificationXref
id: Q3ZBW4
db: uniprot

uniprot C0HL67 50
type: UnificationXref
id: C0HL67
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot B3RWE2 41
xref: PTHR11426:SF20
organism: Trichoplax adhaerens

uniprot P30189 190
type: UnificationXref
id: P30189
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot E9H1C5 69
xref: PTHR11426:SF236
organism: Daphnia pulex

Histone H3
type: ProteinReference
xref: PTHR11426:SF218
xref: uniprot W4YRY4 156
organism: Strongylocentrotus purpuratus

PTHR11426:SF101
type: RelationshipXref
id: PTHR11426:SF101
db: PANTHER Family
relationship type: By Homology

DNA polymerase delta subunit 2
type: ProteinReference
xref: uniprot Q1K7B3 233
xref: PTHR10416:SF0
organism: Neurospora crassa

Histone H3
type: ProteinReference
xref: uniprot W4Z226 158
xref: PTHR11426:SF20
organism: Strongylocentrotus purpuratus

DNA primase
type: ProteinReference
xref: uniprot H2R0Q8 6
xref: PTHR10536:SF0
organism: Pan troglodytes

uniprot P30181 276
type: UnificationXref
id: P30181
db: uniprot

uniprot P84247 120
type: UnificationXref
id: P84247
db: uniprot

Pol delta
type: Protein
entity reference: Pol delta
comment: SPECIES_TYPE=PROTEIN

uniprot P06786 186
type: UnificationXref
id: P06786
db: uniprot

uniprot B5DF29 163
type: UnificationXref
id: B5DF29
db: uniprot

PARTICIPANT STOICHIOMETRY re11 401
type: Stoichiometry
physical entity: ADPs + Pi
stoichiometric coefficient: 1.0

Primase
type: Protein
entity reference: Primase
feature: COMPLEX PARTICIPANT BINDING FEATURE s80 sa11 309
comment: SPECIES_TYPE=PROTEIN

Polymerase (DNA directed), delta 2, regulatory subunit
type: ProteinReference
xref: uniprot B0R0V1 218
xref: PTHR10416:SF0
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re11 400
type: Stoichiometry
physical entity: dsDNA-primase complex
stoichiometric coefficient: 1.0

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 123

uniprot A7SEB4 23
type: UnificationXref
id: A7SEB4
db: uniprot

PARTICIPANT STOICHIOMETRY r67 396
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 1.0

Histone H3
type: ProteinReference
xref: uniprot W4YRX5 155
xref: PTHR11426:SF20
organism: Strongylocentrotus purpuratus

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 304

PARTICIPANT STOICHIOMETRY r67 395
type: Stoichiometry
physical entity: dsDNA-replication complex
stoichiometric coefficient: 1.0

Histone H3
type: ProteinReference
xref: uniprot E1BGN3 62
xref: PTHR11426:SF203
organism: Bos taurus

RNase H
type: ProteinReference
xref: P00538
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.RNase H
comment: ENTITY_REFERENCE_NOTES=Long Name: RNase H Synonym: Synonym not specified Accession: P00538
member entity reference: Ribonuclease HII
member entity reference: Ribonuclease H1
member entity reference: Ribonuclease HI
member entity reference: Uncharacterized protein
member entity reference: Ribonuclease H
member entity reference: RNA exonuclease 1

ncbitaxon 7955 34
type: UnificationXref
id: 7955
db: ncbitaxon

ncbitaxon 54126 93
type: UnificationXref
id: 54126
db: ncbitaxon

dsDNA
type: Complex
component stoichiometry: Hel s96 a74 STOICHIOMETRY ID COMPLEX
component stoichiometry: RPA s98 a94 STOICHIOMETRY ID COMPLEX
component stoichiometry: Top s94 a73 STOICHIOMETRY ID COMPLEX
component stoichiometry: ssDNA s97 a88 STOICHIOMETRY ID COMPLEX
component stoichiometry: dsDNA s95 a21 STOICHIOMETRY ID COMPLEX
component: Top
component: RPA
component: dsDNA
component: Hel
component: ssDNA
feature: COMPLEX BINDING FEATURE s93 csa13 368
feature: COMPLEX BINDING FEATURE s93 csa13 364
feature: COMPLEX BINDING FEATURE s93 csa13 362
feature: COMPLEX BINDING FEATURE s93 csa13 360
feature: COMPLEX BINDING FEATURE s93 csa13 366

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 262

uniprot P84227 116
type: UnificationXref
id: P84227
db: uniprot

Histone H3.3 type 2
type: ProteinReference
xref: PTHR11426:SF118
xref: uniprot Q9U281 146
organism: Caenorhabditis elegans

ncbitaxon 185431 196
type: UnificationXref
id: 185431
db: ncbitaxon

uniprot Q9HN45 261
type: UnificationXref
id: Q9HN45
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot D3ZJ08 60
xref: PTHR11426:SF20
organism: Rattus norvegicus

uniprot Q9U0H1 210
type: UnificationXref
id: Q9U0H1
db: uniprot

Hel
type: Protein
entity reference: Hel
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 a133 315
comment: SPECIES_TYPE=PROTEIN

Histone H3
type: ProteinReference
xref: uniprot W4XWM4 151
xref: PTHR11426:SF20
organism: Strongylocentrotus purpuratus

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 141

ncbitaxon 7719 80
type: UnificationXref
id: 7719
db: ncbitaxon

DNA topoisomerase I, mitochondrial
type: ProteinReference
xref: uniprot Q8R4U6 282
organism: Mus musculus

Replication protein A2
type: ProteinReference
xref: uniprot Q504I6 288
xref: PTHR13989:SF16
organism: Danio rerio

Ribonuclease H
type: ProteinReference
xref: uniprot Q57XA9 299
xref: PTHR10642:SF23
organism: Trypanosoma brucei

dsDNA s65 a162 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 1.0

Chromatin (DNA + Histones + Other Proteins) Replication_Competant_State
type: DnaRegion
comment: SPECIES_TYPE=GENE

DNA polymerase
type: ProteinReference
xref: uniprot F6Z608 203
xref: PTHR45861:SF1
organism: Xenopus tropicalis

DNA topoisomerase I
type: ProteinReference
xref: uniprot H9FZ51 181
organism: Macaca mulatta

IDA
type: EvidenceCodeVocabulary

Replication protein A 32 kDa subunit
type: ProteinReference
xref: PTHR13989:SF10
xref: uniprot P15927 286
organism: Homo sapiens

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 42

PCNA
type: Protein
entity reference: PCNA
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa5 339
comment: SPECIES_TYPE=PROTEIN

PANTHER Pathway P00017 1
type: UnificationXref
id: P00017
db: PANTHER Pathway

By Homology
type: RelationshipTypeVocabulary

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 229

uniprot P30182 277
type: UnificationXref
id: P30182
db: uniprot

Complex Pol alpha Primase s68 a202 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Complex (Pol alpha/Primase)
stoichiometric coefficient: 1.0

ncbitaxon 6669 70
type: UnificationXref
id: 6669
db: ncbitaxon

PTHR10169:SF50
type: RelationshipXref
id: PTHR10169:SF50
db: PANTHER Family
relationship type: By Homology

Histone H3.3
type: ProteinReference
xref: uniprot Q6PI20 139
xref: PTHR11426:SF236
organism: Danio rerio

ncbitaxon 684364 72
type: UnificationXref
id: 684364
db: ncbitaxon

Complex (PCNA/RFC/ Pol delta)
type: Complex
component stoichiometry: PCNA s5 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: Pol delta s7 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: RFC s6 sa6 STOICHIOMETRY ID COMPLEX
component: Pol delta
component: RFC
component: PCNA
feature: COMPLEX BINDING FEATURE s58 a199 338
feature: COMPLEX BINDING FEATURE s58 a199 342
feature: COMPLEX BINDING FEATURE s58 a199 340
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 a199 345

DNA topoisomerase 2-alpha
type: ProteinReference
xref: uniprot Q01320 192
organism: Mus musculus

uniprot Q5BK46 300
type: UnificationXref
id: Q5BK46
db: uniprot

uniprot Q9U281 146
type: UnificationXref
id: Q9U281
db: uniprot

uniprot A8XE06 35
type: UnificationXref
id: A8XE06
db: uniprot

uniprot P11387 187
type: UnificationXref
id: P11387
db: uniprot

dsDNA
type: Complex
component stoichiometry: RPA s103 a106 STOICHIOMETRY ID COMPLEX
component stoichiometry: dsDNA s100 a99 STOICHIOMETRY ID COMPLEX
component stoichiometry: Top s104 a98 STOICHIOMETRY ID COMPLEX
component stoichiometry: ssDNA s102 a105 STOICHIOMETRY ID COMPLEX
component stoichiometry: Hel s101 a103 STOICHIOMETRY ID COMPLEX
component: RPA
component: Top
component: ssDNA
component: dsDNA
component: Hel
feature: COMPLEX PARTICIPANT BINDING FEATURE s99 csa14 383
feature: COMPLEX BINDING FEATURE s99 csa14 376
feature: COMPLEX BINDING FEATURE s99 csa14 378
feature: COMPLEX BINDING FEATURE s99 csa14 374
feature: COMPLEX BINDING FEATURE s99 csa14 370
feature: COMPLEX BINDING FEATURE s99 csa14 372

uniprot P07041 99
type: UnificationXref
id: P07041
db: uniprot

uniprot Q6NXT2 138
type: UnificationXref
id: Q6NXT2
db: uniprot

Ribonuclease H
type: ProteinReference
xref: uniprot Q9UST8 305
xref: PTHR10642:SF23
organism: Schizosaccharomyces pombe

uniprot Q9D0F6 176
type: UnificationXref
id: Q9D0F6
db: uniprot

PARTICIPANT STOICHIOMETRY r24 417
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot P49005 228
type: UnificationXref
id: P49005
db: uniprot

PARTICIPANT STOICHIOMETRY r24 418
type: Stoichiometry
physical entity: ADP + Pi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 419
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 413
type: Stoichiometry
physical entity: Top
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 414
type: Stoichiometry
physical entity: Chromatin (DNA + Histones + Other Proteins) Replication_Competant_State
stoichiometric coefficient: 1.0

Histone H3
type: ProteinReference
xref: uniprot W4ZHT8 161
xref: PTHR11426:SF20
organism: Strongylocentrotus purpuratus

PARTICIPANT STOICHIOMETRY r24 415
type: Stoichiometry
physical entity: RPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 416
type: Stoichiometry
physical entity: Hel
stoichiometric coefficient: 1.0

DNA polymerase delta subunit 2
type: ProteinReference
xref: uniprot O35654 222
xref: PTHR10416:SF0
organism: Mus musculus

Histone H3
type: ProteinReference
xref: PTHR11426:SF101
xref: uniprot A7EW99 19
organism: Sclerotinia sclerotiorum

ncbitaxon 69014 253
type: UnificationXref
id: 69014
db: ncbitaxon

ncbitaxon 9544 76
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot P68433 114
type: UnificationXref
id: P68433
db: uniprot

uniprot E2R0D6 239
type: UnificationXref
id: E2R0D6
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 104

Histone H3 (Fragment)
type: ProteinReference
xref: uniprot A7T7J5 26
xref: PTHR11426:SF201
organism: Nematostella vectensis

Top
type: Protein
entity reference: Top
comment: SPECIES_TYPE=PROTEIN

DNA polymerase
type: ProteinReference
xref: uniprot F1LRJ6 202
xref: PTHR45861:SF1
organism: Rattus norvegicus

uniprot P30316 226
type: UnificationXref
id: P30316
db: uniprot

DNA polymerase delta subunit 2
type: ProteinReference
xref: PTHR10416:SF0
xref: uniprot Q6AXY4 234
organism: Rattus norvegicus

uniprot W4XZV8 152
type: UnificationXref
id: W4XZV8
db: uniprot

uniprot Q7PCS9 140
type: UnificationXref
id: Q7PCS9
db: uniprot

Batrachochytrium dendrobatidis
type: BioSource
xref: ncbitaxon 684364 72

uniprot A8KBJ5 33
type: UnificationXref
id: A8KBJ5
db: uniprot

uniprot A0A3Q1MF00 2
type: UnificationXref
id: A0A3Q1MF00
db: uniprot

uniprot C3YMG9 55
type: UnificationXref
id: C3YMG9
db: uniprot

uniprot Q5E9F8 136
type: UnificationXref
id: Q5E9F8
db: uniprot

Primase
type: Protein
entity reference: Primase
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa2 329
comment: SPECIES_TYPE=PROTEIN

DNA polymerase
type: ProteinReference
xref: uniprot A0A1D5R2G0 217
xref: PTHR10322:SF23
organism: Macaca mulatta

ssDNA
type: DnaRegion
feature: COMPLEX PARTICIPANT BINDING FEATURE s63 a157 351
comment: SPECIES_TYPE=GENE

RFC
type: ProteinReference
xref: P00529
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.RFC
comment: ENTITY_REFERENCE_NOTES=Long Name: RFC Synonym: Replication Factor C Accession: P00529
member entity reference: Replication factor C subunit 2
member entity reference: Replication factor C (Activator 1) 3
member entity reference: tRNA-splicing ligase RtcB
member entity reference: Replication factor C subunit 3
member entity reference: Replication factor C subunit 5
member entity reference: Replication factor C (Activator 1) 4 (Predicted), isoform CRA_a
member entity reference: Replication factor C subunit 1
member entity reference: Replication factor C subunit 4
member entity reference: Replication factor C (Activator 1) 5

uniprot A7T8N3 27
type: UnificationXref
id: A7T8N3
db: uniprot

STATE_TRANSITION_LEFT__dsDNA-_Histones-_ATP-RIGHT__ADP__PLUS__Pi-_Chromatin__DNA__PLUS__Histones__PLUS__Other_Proteins_-_r69
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 384
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 388
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 385
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 386
participant stoichiometry: PARTICIPANT STOICHIOMETRY r69 387
left: ATP
left: Histones
left: dsDNA
interaction type: STATE_TRANSITION
right: ADP + Pi
right: Chromatin (DNA + Histones + Other Proteins)

Ribonuclease HII
type: ProteinReference
xref: PTHR10954:SF7
xref: uniprot Q9HNR3 302
organism: Halobacterium salinarum

ncbitaxon 9258 82
type: UnificationXref
id: 9258
db: ncbitaxon

Replication factor C subunit 3
type: ProteinReference
xref: uniprot Q8R323 173
organism: Mus musculus

Histone H3.3
type: ProteinReference
xref: PTHR11426:SF228
xref: uniprot P84245 119
organism: Rattus norvegicus

DNA polymerase delta subunit 2
type: ProteinReference
xref: uniprot F6PLY1 220
xref: PTHR10416:SF0
organism: Macaca mulatta

Histone H3.3
type: ProteinReference
xref: uniprot P84247 120
xref: PTHR11426:SF236
organism: Gallus gallus

Histone H3
type: ProteinReference
xref: uniprot F7F1M9 86
xref: PTHR11426:SF236
organism: Ornithorhynchus anatinus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 14

uniprot J9PAY8 270
type: UnificationXref
id: J9PAY8
db: uniprot

Primase
type: ProteinReference
xref: P00528
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.Primase
comment: ENTITY_REFERENCE_NOTES=
member entity reference: DNA primase small subunit
member entity reference: DNA primase
member entity reference: DNA primase small subunit PriS
member entity reference: DNA primase large subunit

Histone H3.3
type: ProteinReference
xref: PTHR11426:SF228
xref: uniprot P84244 118
organism: Mus musculus

DNA topoisomerase 2
type: ProteinReference
xref: uniprot F1MU48 266
organism: Bos taurus

uniprot W4Z226 158
type: UnificationXref
id: W4Z226
db: uniprot

Replication factor C (Activator 1) 4 (Predicted), isoform CRA_a
type: ProteinReference
xref: uniprot B4F778 162
organism: Rattus norvegicus

Top
type: Protein
entity reference: Top
feature: COMPLEX PARTICIPANT BINDING FEATURE s74 a138 317
comment: SPECIES_TYPE=PROTEIN

Primase s70 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Primase
stoichiometric coefficient: 1.0

RPA
type: Protein
entity reference: RPA
feature: COMPLEX PARTICIPANT BINDING FEATURE s98 a94 369
comment: SPECIES_TYPE=PROTEIN

DNA polymerase delta catalytic subunit
type: ProteinReference
xref: uniprot Q9LRE6 238
xref: PTHR10322:SF23
organism: Oryza sativa

RNase H
type: Protein
entity reference: RNase H
comment: SPECIES_TYPE=PROTEIN

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 95

DNA polymerase delta small subunit
type: ProteinReference
xref: uniprot Q9LRE5 237
xref: PTHR10416:SF0
organism: Oryza sativa

uniprot P35250 166
type: UnificationXref
id: P35250
db: uniprot

uniprot D3ZK97 61
type: UnificationXref
id: D3ZK97
db: uniprot

uniprot Q4Q836 278
type: UnificationXref
id: Q4Q836
db: uniprot

DNA polymerase
type: ProteinReference
xref: uniprot Q4QEL1 207
xref: PTHR45861:SF1
organism: Leishmania major

PCNA
type: ProteinReference
xref: P00534
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.PCNA
comment: ENTITY_REFERENCE_NOTES=Long Name: PCNA Synonym: Synonym not specified Accession: P00534
member entity reference: Proliferating cell nuclear antigen
member entity reference: DNA polymerase sliding clamp 1
member entity reference: DNA polymerase sliding clamp 2
member entity reference: DNA polymerase sliding clamp

Histone H3.3
type: ProteinReference
xref: PTHR11426:SF101
xref: uniprot Q5ADQ0 135
organism: Candida albicans

uniprot O89044 8
type: UnificationXref
id: O89044
db: uniprot

uniprot D3ZFT1 164
type: UnificationXref
id: D3ZFT1
db: uniprot

uniprot A7TAJ3 28
type: UnificationXref
id: A7TAJ3
db: uniprot

Pol alpha
type: ProteinReference
xref: P00531
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.Pol _alpha_
comment: ENTITY_REFERENCE_NOTES=
member entity reference: DNA polymerase alpha catalytic subunit
member entity reference: DNA polymerase

Histone H3.2
type: ProteinReference
xref: uniprot P84228 117
xref: PTHR11426:SF20
organism: Mus musculus

Histone H3.2
type: ProteinReference
xref: uniprot P84227 116
xref: PTHR11426:SF20
organism: Bos taurus

uniprot W4ZE70 160
type: UnificationXref
id: W4ZE70
db: uniprot

uniprot H3I1F0 94
type: UnificationXref
id: H3I1F0
db: uniprot

uniprot P33609 206
type: UnificationXref
id: P33609
db: uniprot

uniprot Q6ZQJ5 214
type: UnificationXref
id: Q6ZQJ5
db: uniprot

PTHR10416:SF0
type: RelationshipXref
id: PTHR10416:SF0
db: PANTHER Family
relationship type: By Homology

uniprot Q8R323 173
type: UnificationXref
id: Q8R323
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Top-_Chromatin__DNA__PLUS__Histones__PLUS__Other_Proteins__Replication_Competant_State-_RPA-_Hel-_ATP-RIGHT__ADP__PLUS__Pi-_dsDNA-_r24
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 418
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 415
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 414
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 419
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 417
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 416
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 413
left: Top
left: ATP
left: Hel
left: RPA
left: Chromatin (DNA + Histones + Other Proteins) Replication_Competant_State
interaction type: HETERODIMER_ASSOCIATION
right: ADP + Pi
right: dsDNA

Histone H3, embryonic
type: ProteinReference
xref: uniprot P06352 98
xref: PTHR11426:SF201
organism: Strongylocentrotus purpuratus

STATE_TRANSITION_LEFT__ATPs-_dsDNA_primase_complex-_RFC-RIGHT__ADPs__PLUS__Pi-_dsDNA_primase_RFC_complex-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 404
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 403
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 406
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 405
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 402
left: ATPs
left: dsDNA-primase complex
left: RFC
interaction type: STATE_TRANSITION
right: dsDNA-primase-RFC complex
right: ADPs + Pi

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Ribonuclease H1
type: ProteinReference
xref: uniprot Q5BK46 300
xref: PTHR10642:SF23
organism: Rattus norvegicus

ncbitaxon 9615 240
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q57UW4 208
type: UnificationXref
id: Q57UW4
db: uniprot

ncbitaxon 13616 74
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot F7CMG6 85
type: UnificationXref
id: F7CMG6
db: uniprot

Pol alpha
type: Protein
entity reference: Pol alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa8 331
comment: SPECIES_TYPE=PROTEIN

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 196

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 219

Thalassiosira pseudonana
type: BioSource
xref: ncbitaxon 35128 45

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 216

uniprot A5PK61 18
type: UnificationXref
id: A5PK61
db: uniprot

Top
type: Protein
entity reference: Top
feature: COMPLEX PARTICIPANT BINDING FEATURE s94 a73 363
comment: SPECIES_TYPE=PROTEIN

uniprot W4ZCB8 159
type: UnificationXref
id: W4ZCB8
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 22

Replication protein A 32 kDa subunit A
type: ProteinReference
xref: uniprot Q6K9U2 289
xref: PTHR13989:SF41
organism: Oryza sativa

DNA polymerase sliding clamp 1
type: ProteinReference
xref: uniprot Q5JF32 252
xref: PTHR11352:SF0
organism: Thermococcus kodakaraensis

ncbitaxon 6238 36
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot P87324 232
type: UnificationXref
id: P87324
db: uniprot

Histone H3.3B
type: ProteinReference
xref: PTHR11426:SF236
xref: uniprot C0HL67 50
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__Chromatin__DNA__PLUS__Histones__PLUS__Other_Proteins_-RIGHT__Chromatin__DNA__PLUS__Histones__PLUS__Other_Proteins__Replication_Competant_State-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 394
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 393
left: Chromatin (DNA + Histones + Other Proteins)
interaction type: STATE_TRANSITION
right: Chromatin (DNA + Histones + Other Proteins) Replication_Competant_State

ncbitaxon 39947 123
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot B8CC53 49
type: UnificationXref
id: B8CC53
db: uniprot

uniprot A0A1D5R2G0 217
type: UnificationXref
id: A0A1D5R2G0
db: uniprot

Primase
type: Protein
entity reference: Primase
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa4 337
comment: SPECIES_TYPE=PROTEIN

dsDNA-primase complex
type: Complex
component stoichiometry: Complex Pol alpha Primase s90 a193 STOICHIOMETRY ID COMPLEX
component stoichiometry: dsDNA s99 csa14 STOICHIOMETRY ID COMPLEX
component: Complex (Pol alpha/Primase)
component: dsDNA
feature: COMPLEX BINDING FEATURE s84 csa12 380
feature: COMPLEX BINDING FEATURE s84 csa12 382

Proliferating cell nuclear antigen
type: ProteinReference
xref: PTHR11352:SF0
xref: uniprot Q3ZBW4 249
organism: Bos taurus

Histone H3
type: ProteinReference
xref: PTHR11426:SF190
xref: uniprot A8J9M0 32
organism: Chlamydomonas reinhardtii

DNA topoisomerase 2
type: ProteinReference
xref: uniprot Q4Q836 278
organism: Leishmania major

Histone H3.1
type: ProteinReference
xref: uniprot Q4P7J7 130
xref: PTHR11426:SF101
organism: Ustilago maydis

uniprot C3ZYM6 56
type: UnificationXref
id: C3ZYM6
db: uniprot

Histone H3
type: ProteinReference
xref: uniprot Q7PCS9 140
xref: PTHR11426:SF20
organism: Anopheles gambiae

DNA Topisomerase
type: Protein
entity reference: DNA Topisomerase
comment: SPECIES_TYPE=PROTEIN

Primase
type: Protein
entity reference: Primase
feature: COMPLEX PARTICIPANT BINDING FEATURE s70 sa9 333
comment: SPECIES_TYPE=PROTEIN

n H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 7165 141
type: UnificationXref
id: 7165
db: ncbitaxon

dsDNA-replication complex
type: Complex
component stoichiometry: RPA s67 a188 STOICHIOMETRY ID COMPLEX
component stoichiometry: nascent DNA s62 a153 STOICHIOMETRY ID COMPLEX
component stoichiometry: Top s66 a163 STOICHIOMETRY ID COMPLEX
component stoichiometry: ssDNA s63 a157 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex PCNA RFC Pol delta s58 a199 STOICHIOMETRY ID COMPLEX
component stoichiometry: Complex Pol alpha Primase s68 a202 STOICHIOMETRY ID COMPLEX
component stoichiometry: dsDNA s65 a162 STOICHIOMETRY ID COMPLEX
component stoichiometry: Hel s64 a161 STOICHIOMETRY ID COMPLEX
component: Hel
component: ssDNA
component: RPA
component: Complex (Pol alpha/Primase)
component: dsDNA
component: Top
component: nascent DNA
component: Complex (PCNA/RFC/ Pol delta)
feature: COMPLEX BINDING FEATURE s61 csa10 344
feature: COMPLEX BINDING FEATURE s61 csa10 358
feature: COMPLEX BINDING FEATURE s61 csa10 354
feature: COMPLEX BINDING FEATURE s61 csa10 352
feature: COMPLEX BINDING FEATURE s61 csa10 348
feature: COMPLEX BINDING FEATURE s61 csa10 350
feature: COMPLEX BINDING FEATURE s61 csa10 356
feature: COMPLEX BINDING FEATURE s61 csa10 346

uniprot Q8TSZ5 15
type: UnificationXref
id: Q8TSZ5
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot C3XUS0 54
type: UnificationXref
id: C3XUS0
db: uniprot

uniprot A0A0G2K5X7 17
type: UnificationXref
id: A0A0G2K5X7
db: uniprot

uniprot E1BGN3 62
type: UnificationXref
id: E1BGN3
db: uniprot

uniprot B4F778 162
type: UnificationXref
id: B4F778
db: uniprot

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Candida albicans
type: BioSource
xref: ncbitaxon 237561 134

Histone H3
type: ProteinReference
xref: uniprot Q7PUQ8 142
xref: PTHR11426:SF236
organism: Anopheles gambiae

ncbitaxon 35128 45
type: UnificationXref
id: 35128
db: ncbitaxon

ncbitaxon 10228 42
type: UnificationXref
id: 10228
db: ncbitaxon

uniprot F7GJR4 291
type: UnificationXref
id: F7GJR4
db: uniprot

Pol alpha
type: Protein
entity reference: Pol alpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa1 327
comment: SPECIES_TYPE=PROTEIN

Chromatin (DNA + Histones + Other Proteins)
type: DnaRegion
comment: SPECIES_TYPE=GENE

PTHR10642:SF23
type: RelationshipXref
id: PTHR10642:SF23
db: PANTHER Family
relationship type: By Homology

Leishmania major
type: BioSource
xref: ncbitaxon 5664 198

DNA Topisomerase
type: ProteinReference
xref: P00536
standard name: DNA Topoisomerase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: DNA Topoisomerase Synonym: Synonym not specified Accession: P00536
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.DNA Topisomerase
member entity reference: DNA topoisomerase 2-beta
member entity reference: DNA topoisomerase I, mitochondrial
member entity reference: DNA topoisomerase 2-alpha
member entity reference: DNA topoisomerase 2
member entity reference: DNA topoisomerase 1
member entity reference: DNA topoisomerase 1 beta
member entity reference: DNA topoisomerase I
member entity reference: DNA topoisomerase 1 alpha

DNA topoisomerase 2
type: ProteinReference
xref: uniprot P06786 186
organism: Saccharomyces cerevisiae

uniprot C3XPT8 52
type: UnificationXref
id: C3XPT8
db: uniprot

STATE_TRANSITION_LEFT__n_dNTP__PLUS__Mg_PLUS__PLUS_-_PCNA-_Pol_delta-_dsDNA_primase_RFC_complex-RIGHT__dsDNA_replication_complex-_nPPi-_r63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 412
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 408
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 407
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 411
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 410
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 409
left: dsDNA-primase-RFC complex
left: PCNA
left: n dNTP + Mg++
left: Pol delta
interaction type: STATE_TRANSITION
right: dsDNA-replication complex
right: nPPi

Top s104 a98 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Top
stoichiometric coefficient: 2.0

uniprot P40937 169
type: UnificationXref
id: P40937
db: uniprot

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 125

DNA topoisomerase 1
type: ProteinReference
xref: uniprot Q04750 194
organism: Mus musculus

DNA topoisomerase 2
type: ProteinReference
xref: uniprot Q4QF53 197
xref: PTHR10169:SF50
organism: Leishmania major

uniprot H2QKC9 180
type: UnificationXref
id: H2QKC9
db: uniprot

RPA
type: ProteinReference
xref: P00537
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DNA replication.PROTEIN.GENERIC.RPA
comment: ENTITY_REFERENCE_NOTES=Long Name: RPA Synonym: Replication Protein A Accession: P00537
member entity reference: Replication factor A protein 2
member entity reference: Replication protein A2, 32kDa
member entity reference: Replication protein A 32 kDa subunit A
member entity reference: Replication protein A2
member entity reference: Replication protein A 32 kDa subunit

uniprot O54747 223
type: UnificationXref
id: O54747
db: uniprot

DNA topoisomerase 2-beta
type: ProteinReference
xref: uniprot Q02880 193
organism: Homo sapiens

DNA polymerase delta 2, accessory subunit
type: ProteinReference
xref: PTHR10416:SF0
xref: uniprot H2R5C2 221
organism: Pan troglodytes

dsDNA s95 a21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: dsDNA
stoichiometric coefficient: 2.0

ncbitaxon 665079 20
type: UnificationXref
id: 665079
db: ncbitaxon

Histone H3
type: ProteinReference
xref: uniprot P23753 108
xref: PTHR11426:SF101
organism: Emericella nidulans

ncbitaxon 214684 106
type: UnificationXref
id: 214684
db: ncbitaxon

Histone H3
type: ProteinReference
xref: PTHR11426:SF118
xref: uniprot A8XE06 35
organism: Caenorhabditis briggsae

Hel
type: Protein
entity reference: Hel
comment: SPECIES_TYPE=PROTEIN

uniprot F7GHH9 88
type: UnificationXref
id: F7GHH9
db: uniprot

ncbitaxon 237561 134
type: UnificationXref
id: 237561
db: ncbitaxon

Monosiga brevicollis
type: BioSource
xref: ncbitaxon 81824 39

Ribonuclease H
type: ProteinReference
xref: uniprot Q04740 298
xref: PTHR10642:SF23
organism: Saccharomyces cerevisiae

ncbitaxon 9606 14
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot P20664 10
type: UnificationXref
id: P20664
db: uniprot

uniprot K7CLW1 183
type: UnificationXref
id: K7CLW1
db: uniprot

Top s94 a73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Top
stoichiometric coefficient: 2.0

uniprot H2QHD3 292
type: UnificationXref
id: H2QHD3
db: uniprot