? s43 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

MAD s120 sa103 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

PUT
type: Protein
entity reference: PUT

MAD
type: Protein
entity reference: MAD
feature: MAD s144 sa109 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s144 sa109 136
feature: MAD s144 sa109 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re15 236
type: Stoichiometry
physical entity: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 237
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 238
type: Stoichiometry
physical entity: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer MAD
stoichiometric coefficient: 1.0

DPP s10 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

SOG
type: Protein
entity reference: SOG
feature: COMPLEX PARTICIPANT BINDING FEATURE s55 sa49 170
comment: SPECIES_TYPE=PROTEIN

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

DPP s23 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 247
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re12 246
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 1.0

HOMODIMER ID 48STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

SAX s5 sa4 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.53

TKV s70 sa52 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

HOMODIMER ID 39STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

By Homology
type: RelationshipTypeVocabulary

MAD
type: Protein
entity reference: MAD
feature: MAD s106 sa79 rs1
feature: MAD s106 sa79 rs2

Protein twisted gastrulation
type: ProteinReference
xref: PTHR12312:SF16
xref: uniprot P54356 35
organism: Drosophila melanogaster

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s54 sa48 168
comment: SPECIES_TYPE=PROTEIN

PUT
type: Protein
entity reference: PUT

uniprot A0A0B4KG59 6
type: UnificationXref
id: A0A0B4KG59
db: uniprot

TLD
type: Protein
entity reference: TLD
comment: SPECIES_TYPE=PROTEIN

uniprot Q24025 50
type: UnificationXref
id: Q24025
db: uniprot

SHN
type: Protein
entity reference: SHN
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 7

DPP/SCW TKV/SAX
type: Complex
component stoichiometry: SAX s8 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: SCW s11 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: DPP s10 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: TKV s9 sa7 STOICHIOMETRY ID COMPLEX
component: DPP
component: SAX
component: SCW
component: TKV
feature: COMPLEX BINDING FEATURE s7 csa3 183
feature: COMPLEX BINDING FEATURE s7 csa3 181
feature: COMPLEX BINDING FEATURE s7 csa3 185
feature: COMPLEX BINDING FEATURE s7 csa3 179
cellular location: cytosol

NEJ/MED/ phosphoMAD
type: Complex
component stoichiometry: HOMODIMER ID 40STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s121 sa104 STOICHIOMETRY ID COMPLEX
component stoichiometry: NEJ s122 sa105 STOICHIOMETRY ID COMPLEX
component: NEJ
component: MAD
component: MED
feature: COMPLEX BINDING FEATURE s119 csa23 139
feature: COMPLEX BINDING FEATURE s119 csa23 143
feature: COMPLEX BINDING FEATURE s119 csa23 141
cellular location: nucleus

STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re31
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 196
left: phosphoMAD LACK
interaction type: STATE_TRANSITION
right: phosphoMAD LACK

PTHR13703:SF61
type: RelationshipXref
id: PTHR13703:SF61
db: PANTHER Family
relationship type: By Homology

PDP
type: ProteinReference
xref: P06262
standard name: pyruvate dehydrogenase phosphatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.PDP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: GM14286p

TKV/SAX DPP/SCW PUT dimer
type: Complex
component stoichiometry: TKV dimer SAX dimer s89 csa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: DPP s16 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: SCW s15 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 14STOICHIOMETRY ID COMPLEX
component: TKV dimer/ SAX dimer
component: DPP
component: PUT
component: SCW
feature: COMPLEX BINDING FEATURE s13 csa4 95
feature: COMPLEX BINDING FEATURE s13 csa4 99
feature: COMPLEX BINDING FEATURE s13 csa4 97
feature: COMPLEX BINDING FEATURE s13 csa4 93
cellular location: cytosol

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s121 sa104 142
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TKV
type: Protein
entity reference: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa7 182
feature: TKV s9 sa7 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SCW s95 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

NEJ
type: Protein
entity reference: NEJ
feature: COMPLEX PARTICIPANT BINDING FEATURE s122 sa105 144
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAD
type: Protein
entity reference: MAD
feature: MAD s129 sa101 rs1
feature: MAD s129 sa101 rs2

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s143 sa110 138
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SAX s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 1.0

HOMODIMER ID 37STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re29 256
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 255
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PTHR47992:SF25
type: RelationshipXref
id: PTHR47992:SF25
db: PANTHER Family
relationship type: By Homology

MAD
type: Protein
entity reference: MAD
feature: MAD s131 sa83 rs1
feature: MAD s131 sa83 rs2
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TKV
type: Protein
entity reference: TKV
feature: TKV s17 sa13 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa13 92
comment: SPECIES_TYPE=PROTEIN

LACK s141 sa112 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

DPP full length
type: Protein
entity reference: DPP full length
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa29 72
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

SAX
type: Protein
entity reference: SAX
feature: SAX s72 sa53 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 sa53 56
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

SCW s66 sa40 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__SAX-_TKV-RIGHT__TKV_SAX-_re11
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 249
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 250
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 248
left: SAX
left: TKV
interaction type: HETERODIMER_ASSOCIATION
right: TKV/SAX

eco ECO:0000501 8
type: UnificationXref
id: ECO:0000501
db: eco

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

phosphoTKV/ phosphoSAX DPP/SCW PUT dimer
type: Complex
component stoichiometry: SCW s22 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 13STOICHIOMETRY ID COMPLEX
component stoichiometry: phosphoTKV phosphoSAX s90 csa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: DPP s23 sa17 STOICHIOMETRY ID COMPLEX
component: phosphoTKV/ phosphoSAX
component: PUT
component: DPP
component: SCW
feature: COMPLEX BINDING FEATURE s27 csa5 67
feature: COMPLEX BINDING FEATURE s27 csa5 69
feature: COMPLEX BINDING FEATURE s27 csa5 65
feature: COMPLEX BINDING FEATURE s27 csa5 63
cellular location: cytosol

uniprot P42003 23
type: UnificationXref
id: P42003
db: uniprot

uniprot P07713 27
type: UnificationXref
id: P07713
db: uniprot

P06271
type: UnificationXref
id: P06271
db: PANTHER Pathway Component

P06272
type: UnificationXref
id: P06272
db: PANTHER Pathway Component

P06270
type: UnificationXref
id: P06270
db: PANTHER Pathway Component

P06275
type: UnificationXref
id: P06275
db: PANTHER Pathway Component

MAD
type: Protein
entity reference: MAD
feature: MAD s115 sa98 rs1
feature: MAD s115 sa98 rs2

SCW s32 sa31 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

P06273
type: UnificationXref
id: P06273
db: PANTHER Pathway Component

P06274
type: UnificationXref
id: P06274
db: PANTHER Pathway Component

MAD
type: Protein
entity reference: MAD
feature: MAD s109 sa81 rs2
feature: MAD s109 sa81 rs1

TKV/SAX
type: Complex
component stoichiometry: SAX s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: TKV s6 sa5 STOICHIOMETRY ID COMPLEX
component: TKV
component: SAX
feature: COMPLEX BINDING FEATURE s4 csa2 53
feature: COMPLEX BINDING FEATURE s4 csa2 51
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re18 218
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

phosphoTKV/ phosphoSAX
type: Complex
component stoichiometry: SAX s100 sa72 STOICHIOMETRY ID COMPLEX
component stoichiometry: TKV s101 sa73 STOICHIOMETRY ID COMPLEX
component: TKV
component: SAX
feature: COMPLEX BINDING FEATURE s98 csa19 103
feature: COMPLEX PARTICIPANT BINDING FEATURE s98 csa19 106
feature: COMPLEX BINDING FEATURE s98 csa19 101
cellular location: cytosol

PUT s97 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa61 162
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TKV
type: Protein
entity reference: TKV
feature: TKV s93 sa18 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s93 sa18 62
comment: SPECIES_TYPE=PROTEIN

MAD s79 sa58 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re18 217
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

SCW s41 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

TKV
type: Protein
entity reference: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s73 sa54 58
feature: TKV s73 sa54 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 116
comment: SPECIES_TYPE=PROTEIN

PTHR11848:SF54
type: RelationshipXref
id: PTHR11848:SF54
db: PANTHER Family
relationship type: By Homology

TKV s25 sa67 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

SAX
type: ProteinReference
xref: P06274
standard name: saxophone
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.RECEPTOR.SAX
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

PARTICIPANT STOICHIOMETRY re19 214
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

SAX s21 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 213
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 212
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 211
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re9 200
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa40 128
cellular location: unknown c3
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re9 201
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re9 202
type: Stoichiometry
physical entity: SOG/TSG DPP/SCW
stoichiometric coefficient: 1.0

MAD s120 sa103 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

DPP/SCW full length
type: Complex
component stoichiometry: DPP full length s30 sa29 STOICHIOMETRY ID COMPLEX
component stoichiometry: SCW full length s19 sa30 STOICHIOMETRY ID COMPLEX
component: SCW full length
component: DPP full length
feature: COMPLEX BINDING FEATURE s29 csa6 71
feature: COMPLEX BINDING FEATURE s29 csa6 73
cellular location: Golgi apparatus

SAX
type: Protein
entity reference: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 sa72 102
feature: SAX s100 sa72 rs1
comment: SPECIES_TYPE=PROTEIN

SOG
type: Protein
entity reference: SOG
comment: SPECIES_TYPE=PROTEIN

TKV s73 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 1.0

MAD s99 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

TKV
type: Protein
entity reference: TKV
feature: TKV s70 sa52 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

MAD s99 sa70 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 2

PARTICIPANT STOICHIOMETRY re30 198
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re30 197
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

eco ECO:0000316 31
type: UnificationXref
id: ECO:0000316
db: eco

PUT
type: Protein
entity reference: PUT

P06259
type: UnificationXref
id: P06259
db: PANTHER Pathway Component

proDPP/proSCW
type: Complex
component stoichiometry: DPP s33 sa32 STOICHIOMETRY ID COMPLEX
component stoichiometry: SCW s32 sa31 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
component: DPP
component: SCW
component: ?
feature: COMPLEX BINDING FEATURE s31 csa7 177
feature: COMPLEX BINDING FEATURE s31 csa7 173
feature: COMPLEX BINDING FEATURE s31 csa7 175
cellular location: Golgi apparatus

P06258
type: UnificationXref
id: P06258
db: PANTHER Pathway Component

uniprot Q9W3Q1 24
type: UnificationXref
id: Q9W3Q1
db: uniprot

MAD s120 sa103 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TKV s101 sa73 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 1.0

SAX s14 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 1.0

NEJ s122 sa105 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NEJ
stoichiometric coefficient: 1.0

SAX
type: Protein
entity reference: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 52
feature: SAX s5 sa4 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MED s121 sa104 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

Dorsal-ventral patterning protein Sog
type: ProteinReference
xref: uniprot Q24025 50
xref: PTHR46526:SF1
organism: Drosophila melanogaster

DPP s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 5

MAD s99 sa70 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

LACK
type: ProteinReference
xref: P06269
standard name: lethal with a checkpoint kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.LACK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: E3 ubiquitin-protein ligase Smurf1

PTHR13832:SF571
type: RelationshipXref
id: PTHR13832:SF571
db: PANTHER Family
relationship type: By Homology

P06262
type: UnificationXref
id: P06262
db: PANTHER Pathway Component

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa31 174
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

TRUNCATION
type: RelationshipTypeVocabulary

P06263
type: UnificationXref
id: P06263
db: PANTHER Pathway Component

P06264
type: UnificationXref
id: P06264
db: PANTHER Pathway Component

TSG
type: Protein
entity reference: TSG
comment: SPECIES_TYPE=PROTEIN

P06265
type: UnificationXref
id: P06265
db: PANTHER Pathway Component

SAX s92 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 1.0

P06260
type: UnificationXref
id: P06260
db: PANTHER Pathway Component

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s130 sa102 88
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

P06261
type: UnificationXref
id: P06261
db: PANTHER Pathway Component

PUT
type: ProteinReference
xref: P06270
standard name: punt
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.RECEPTOR.PUT
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Serine/threonine-protein kinase receptor

TSG
type: ProteinReference
xref: P06258
standard name: twisted gastrulation
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.TSG
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein twisted gastrulation

P06266
type: UnificationXref
id: P06266
db: PANTHER Pathway Component

P06267
type: UnificationXref
id: P06267
db: PANTHER Pathway Component

P06268
type: UnificationXref
id: P06268
db: PANTHER Pathway Component

P06269
type: UnificationXref
id: P06269
db: PANTHER Pathway Component

MED s116 sa99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

phosphoTKV/ phosphoSAX
type: Complex
component stoichiometry: TKV s93 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: SAX s92 sa15 STOICHIOMETRY ID COMPLEX
component: TKV
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s90 csa16 64
feature: COMPLEX BINDING FEATURE s90 csa16 61
feature: COMPLEX BINDING FEATURE s90 csa16 59
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re16 230
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re16 231
type: Stoichiometry
physical entity: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer phosphoMAD
stoichiometric coefficient: 1.0

DPP/proSCW
type: Complex
component stoichiometry: DPP s40 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: SCW s41 sa43 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 48STOICHIOMETRY ID COMPLEX
component: SCW
component: ?
component: DPP
feature: COMPLEX BINDING FEATURE s39 csa10 123
feature: COMPLEX BINDING FEATURE s39 csa10 121
feature: COMPLEX BINDING FEATURE s39 csa10 119

PARTICIPANT STOICHIOMETRY re16 232
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 2.0

? s42 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa35 146
cellular location: unknown c3
comment: SPECIES_TYPE=PROTEIN

uniprot Q961C5 42
type: UnificationXref
id: Q961C5
db: uniprot

MAD s139 sa111 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

DPP s110 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

sa105_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

PARTICIPANT STOICHIOMETRY re13 244
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re13 245
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PPM1A
type: ProteinReference
xref: P06261
standard name: protein phosphatase 2C alpha, beta
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.PPM1A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Alphabet, isoform E

TKV s17 sa13 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

PARTICIPANT STOICHIOMETRY re1 240
type: Stoichiometry
physical entity: TKV/SAX
stoichiometric coefficient: 1.0

SAX s8 sa6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.53

PARTICIPANT STOICHIOMETRY re1 241
type: Stoichiometry
physical entity: DPP/SCW TKV/SAX
stoichiometric coefficient: 1.0

SAX s8 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 1.0

TKV/SAX
type: Complex
component stoichiometry: TKV s73 sa54 STOICHIOMETRY ID COMPLEX
component stoichiometry: SAX s72 sa53 STOICHIOMETRY ID COMPLEX
component: TKV
component: SAX
feature: COMPLEX BINDING FEATURE s71 csa13 57
feature: COMPLEX BINDING FEATURE s71 csa13 55
cellular location: endoplasmic reticulum

TRANSPORT_LEFT__TKV_SAX-RIGHT__TKV_SAX-_re14
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 243
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 242
left: TKV/SAX
interaction type: TRANSPORT
right: TKV/SAX

phosphoMAD LACK
type: Complex
component stoichiometry: MAD s139 sa111 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s141 sa112 STOICHIOMETRY ID COMPLEX
component: LACK
component: MAD
feature: COMPLEX BINDING FEATURE s137 csa25 131
feature: COMPLEX BINDING FEATURE s137 csa25 133
cellular location: cytosol

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

PTHR46526:SF1
type: RelationshipXref
id: PTHR46526:SF1
db: PANTHER Family
relationship type: By Homology

TKV s25 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 1.0

00696
type: UnificationXref
id: MOD:00696
db: mod

STATE_TRANSITION_LEFT__ATP-_TKV_SAX_DPP_SCW_PUT_dimer-RIGHT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer-_ADP-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 227
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 225
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 226
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 228
left: TKV/SAX DPP/SCW PUT dimer
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MAD-_MED-_re26
controller: PPM1A

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 8

DISSOCIATION_LEFT__phosphoMAD_LACK-RIGHT__MAD-_LACK-_re32
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 192
left: phosphoMAD LACK
interaction type: DISSOCIATION
right: LACK
right: MAD

TSG s56 sa50 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa16 66
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re16 229
type: Stoichiometry
physical entity: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer MAD
stoichiometric coefficient: 1.0

SHN s117 sa100 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SHN
stoichiometric coefficient: 1.0

TKV
type: ProteinReference
xref: P06267
standard name: thickveins
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.RECEPTOR.TKV
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

HETERODIMER_ASSOCIATION_LEFT__MED__phosphoMAD-_SHN-RIGHT__SHN_MED__phosphoMAD-_re21
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 267
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 268
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 269
left: MED/ phosphoMAD
left: SHN
interaction type: HETERODIMER_ASSOCIATION
right: SHN/MED/ phosphoMAD

HOMODIMER ID 40STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

PTHR23255:SF98
type: RelationshipXref
id: PTHR23255:SF98
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: RelationshipTypeVocabulary

MAD s109 sa81 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__proDPP__proSCW-RIGHT__DPP_proSCW-_?-_re6
controller: FUR1

TRANSPORT_LEFT__PUT-RIGHT__PUT-_re13
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 244
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 245
left: PUT
interaction type: TRANSPORT
right: PUT

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF68
xref: uniprot Q9VMT1 33
organism: Drosophila melanogaster

SCW s81 sa60 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

?
type: Protein

PTHR45645:SF8
type: RelationshipXref
id: PTHR45645:SF8
db: PANTHER Family
relationship type: By Homology

MAD
type: Protein
entity reference: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s99 sa70 112
feature: MAD s99 sa70 rs1
feature: MAD s99 sa70 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein mothers against dpp
type: ProteinReference
xref: uniprot P42003 23
xref: PTHR13703:SF61
organism: Drosophila melanogaster

DPP full length
type: ProteinReference
xref: P06273
standard name: decapentaplegic
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.DPP_br_full length
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein decapentaplegic

HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PUT s12 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

LACK
type: Protein
entity reference: LACK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SAX s21 sa66 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.53

GO GO:0005783 5
type: UnificationXref
id: GO:0005783
db: GO

PTHR11848:SF263
type: RelationshipXref
id: PTHR11848:SF263
db: PANTHER Family
relationship type: By Homology

SAX s100 sa72 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.53

PARTICIPANT STOICHIOMETRY re4 220
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa11 96
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

SOG
type: ProteinReference
xref: P06266
standard name: short gastrulation
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.SOG
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dorsal-ventral patterning protein Sog

PARTICIPANT STOICHIOMETRY re4 221
type: Stoichiometry
physical entity: proDPP/proSCW
stoichiometric coefficient: 1.0

Protein decapentaplegic
type: ProteinReference
evidence: Evidence 28
xref: PTHR11848:SF54
xref: uniprot P07713 27
organism: Drosophila melanogaster

HETERODIMER_ASSOCIATION_LEFT__DPP_proSCW-_TKV_SAX-RIGHT__DPP_SCW_TKV_SAX-_re1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 240
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 239
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 241
left: DPP/proSCW
left: TKV/SAX
interaction type: HETERODIMER_ASSOCIATION
right: DPP/SCW TKV/SAX

uniprot P25723 29
type: UnificationXref
id: P25723
db: uniprot

uniprot P26016 41
type: UnificationXref
id: P26016
db: uniprot

MAD
type: Protein
entity reference: MAD
feature: MAD s120 sa103 rs1
feature: MAD s120 sa103 rs2

?
type: Protein

TKV s93 sa18 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

STATE_TRANSITION
type: RelationshipTypeVocabulary

MAD s129 sa101 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION_LEFT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer-_MAD-RIGHT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer_MAD-_re15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 236
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 237
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 238
left: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer
left: MAD
interaction type: HETERODIMER_ASSOCIATION
right: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer MAD

MAD s109 sa81 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

MED s130 sa102 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__MAD-_MED-RIGHT__MAD-_MED__phosphoMAD-_re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 211
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 214
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 212
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 213
left: MED
left: MAD
interaction type: STATE_TRANSITION
right: MAD
right: MED/ phosphoMAD

MAD
type: Protein
entity reference: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s139 sa111 132
feature: MAD s139 sa111 rs1
feature: MAD s139 sa111 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa12 98
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

phosphoTKV/ phosphoSAX DPP/SCW PUT dimer MAD
type: Complex
component stoichiometry: phosphoTKV phosphoSAX s91 csa17 STOICHIOMETRY ID COMPLEX
component stoichiometry: DPP s82 sa61 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
component stoichiometry: SCW s81 sa60 STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s79 sa58 STOICHIOMETRY ID COMPLEX
component: MAD
component: PUT
component: SCW
component: DPP
component: phosphoTKV/ phosphoSAX
feature: COMPLEX BINDING FEATURE s85 csa14 163
feature: COMPLEX BINDING FEATURE s85 csa14 157
feature: COMPLEX BINDING FEATURE s85 csa14 161
feature: COMPLEX BINDING FEATURE s85 csa14 155
feature: COMPLEX BINDING FEATURE s85 csa14 159
cellular location: cytosol

LACK s143 sa110 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

PUT
type: Protein
entity reference: PUT
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

SHN
type: ProteinReference
xref: P06268
standard name: schnurri
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.SHN
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Schnurri, isoform F

PARTICIPANT STOICHIOMETRY re5 215
type: Stoichiometry
physical entity: proDPP/proSCW
stoichiometric coefficient: 1.0

MAD s109 sa81 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re5 216
type: Stoichiometry
physical entity: proDPP/ proSCW
stoichiometric coefficient: 1.0

SAX s14 sa10 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.53

SCW s36 sa35 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

? s67 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 22
xref: PTHR13703:SF45
xref: uniprot O62609 21
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re2 235
type: Stoichiometry
physical entity: TKV/SAX DPP/SCW PUT dimer
stoichiometric coefficient: 1.0

MAD
type: Protein
entity reference: MAD
feature: MAD s77 sa57 rs1
feature: MAD s77 sa57 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re27 259
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

DPP s16 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

PUT s24 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re1 239
type: Stoichiometry
physical entity: DPP/proSCW
stoichiometric coefficient: 1.0

eco ECO:0000304 34
type: UnificationXref
id: ECO:0000304
db: eco

SOG s55 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa60 160
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re6 208
type: Stoichiometry
physical entity: proDPP/ proSCW
stoichiometric coefficient: 1.0

Serine/threonine-protein kinase receptor
type: ProteinReference
evidence: Evidence 9
xref: uniprot A0A0B4KG59 6
xref: PTHR23255:SF98
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re6 209
type: Stoichiometry
physical entity: DPP/proSCW
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 233
type: Stoichiometry
physical entity: DPP/SCW TKV/SAX
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 234
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

MAD s77 sa57 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SCW s22 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

phosphoTKV phosphoSAX s90 csa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: phosphoTKV/ phosphoSAX
stoichiometric coefficient: 1.0

MED/ phosphoMAD
type: Complex
component stoichiometry: HOMODIMER ID 39STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s130 sa102 STOICHIOMETRY ID COMPLEX
component: MAD
component: MED
feature: COMPLEX BINDING FEATURE s128 csa22 87
feature: COMPLEX BINDING FEATURE s128 csa22 85
cellular location: nucleus

uniprot A0A0B4KFC0 26
type: UnificationXref
id: A0A0B4KFC0
db: uniprot

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MAD-_MED-_re26
controller: PDP

PARTICIPANT STOICHIOMETRY re17 224
type: Stoichiometry
physical entity: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 222
type: Stoichiometry
physical entity: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 223
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

TKV s17 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 1.0

SAX s100 sa72 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__SOG_TSG_DPP_SCW-RIGHT__DPP_proSCW-_SOG-_TSG-_re10
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 254
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 252
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 253
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 251
left: SOG/TSG DPP/SCW
interaction type: DISSOCIATION
right: DPP/proSCW
right: SOG
right: TSG

PARTICIPANT STOICHIOMETRY re27 260
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re4 219
type: Stoichiometry
physical entity: DPP/SCW full length
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 210
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

TKV s101 sa73 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

TSG
type: Protein
entity reference: TSG
feature: COMPLEX PARTICIPANT BINDING FEATURE s56 sa50 172
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 4.0

DPP s82 sa61 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

MAD s77 sa57 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa8 184
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

phosphoTKV phosphoSAX s91 csa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: phosphoTKV/ phosphoSAX
stoichiometric coefficient: 1.0

? s38 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

Dorsal-ventral patterning protein tolloid
type: ProteinReference
xref: uniprot P25723 29
xref: PTHR45645:SF8
organism: Drosophila melanogaster

MED
type: Protein
entity reference: MED
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__SOG_TSG_DPP_SCW-RIGHT__DPP_proSCW-_SOG-_TSG-_re10
controller: TLD

PTHR11254:SF395
type: RelationshipXref
id: PTHR11254:SF395
db: PANTHER Family
relationship type: By Homology

TRANSPORT
type: RelationshipTypeVocabulary

phosphoTKV/ phosphoSAX
type: Complex
component stoichiometry: TKV s25 sa67 STOICHIOMETRY ID COMPLEX
component stoichiometry: SAX s21 sa66 STOICHIOMETRY ID COMPLEX
component: TKV
component: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s91 csa17 156
feature: COMPLEX BINDING FEATURE s91 csa17 153
feature: COMPLEX BINDING FEATURE s91 csa17 151
cellular location: cytosol

MAD s106 sa79 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

TKV s9 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 1.0

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa36 148
cellular location: unknown c3
comment: SPECIES_TYPE=PROTEIN

DPP/proSCW
type: Complex
component stoichiometry: DPP s65 sa39 STOICHIOMETRY ID COMPLEX
component stoichiometry: SCW s66 sa40 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 49STOICHIOMETRY ID COMPLEX
component: DPP
component: ?
component: SCW
feature: COMPLEX BINDING FEATURE s64 csa9 129
feature: COMPLEX BINDING FEATURE s64 csa9 127
feature: COMPLEX BINDING FEATURE s64 csa9 125
cellular location: unknown c3

SCW
type: ProteinReference
xref: P06259
standard name: screw
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.TRUNCATED.SCW
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein screw

Target transcripts
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

MAD s106 sa79 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re21 268
type: Stoichiometry
physical entity: SHN
stoichiometric coefficient: 1.0

TKV
type: Protein
entity reference: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s101 sa73 104
feature: TKV s101 sa73 rs1
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re21 267
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

FUR1
type: ProteinReference
xref: P06263
standard name: furin 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.FUR1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Furin-like protease 1, isoforms 1/1-X/2

MAD s115 sa98 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re21 269
type: Stoichiometry
physical entity: SHN/MED/ phosphoMAD
stoichiometric coefficient: 1.0

MAD s144 sa109 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

PARTICIPANT STOICHIOMETRY re28 257
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 258
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 207
type: Stoichiometry
physical entity: DPP/proSCW
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 206
type: Stoichiometry
physical entity: DPP/proSCW
stoichiometric coefficient: 1.0

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s116 sa99 78
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAD
type: Protein
entity reference: MAD
feature: MAD s104 sa76 rs2
feature: MAD s104 sa76 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

?
type: Protein

TKV dimer/ SAX dimer
type: Complex
component stoichiometry: TKV s17 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: SAX s14 sa10 STOICHIOMETRY ID COMPLEX
component: TKV
component: SAX
feature: COMPLEX BINDING FEATURE s89 csa15 89
feature: COMPLEX PARTICIPANT BINDING FEATURE s89 csa15 94
feature: COMPLEX BINDING FEATURE s89 csa15 91
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re22 265
type: Stoichiometry
physical entity: NEJ
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 263
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 264
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 262
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 261
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 266
type: Stoichiometry
physical entity: NEJ/MED/ phosphoMAD
stoichiometric coefficient: 1.0

TKV dimer SAX dimer s89 csa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV dimer/ SAX dimer
stoichiometric coefficient: 1.0

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

PTHR13808:SF1
type: RelationshipXref
id: PTHR13808:SF1
db: PANTHER Family
relationship type: By Homology

?
type: Protein

PTHR12312:SF16
type: RelationshipXref
id: PTHR12312:SF16
db: PANTHER Family
relationship type: By Homology

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

PARTICIPANT STOICHIOMETRY re31 196
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 195
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

TKV s6 sa5 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

PTHR23255:SF68
type: RelationshipXref
id: PTHR23255:SF68
db: PANTHER Family
relationship type: By Homology

SOG/TSG DPP/SCW
type: Complex
component stoichiometry: SCW s53 sa47 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOG s55 sa49 STOICHIOMETRY ID COMPLEX
component stoichiometry: DPP s54 sa48 STOICHIOMETRY ID COMPLEX
component stoichiometry: TSG s56 sa50 STOICHIOMETRY ID COMPLEX
component: SOG
component: TSG
component: DPP
component: SCW
feature: COMPLEX BINDING FEATURE s52 csa12 169
feature: COMPLEX BINDING FEATURE s52 csa12 165
feature: COMPLEX BINDING FEATURE s52 csa12 167
feature: COMPLEX BINDING FEATURE s52 csa12 171

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa39 126
cellular location: unknown c3
comment: SPECIES_TYPE=PROTEIN

SAX s69 sa51 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.53

MAD s144 sa109 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAD s145 sa106 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Evidence 9
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0003169.html

PTHR23255:SF72
type: RelationshipXref
id: PTHR23255:SF72
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

PUT
type: Protein
entity reference: PUT

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 118
comment: SPECIES_TYPE=PROTEIN

SCW full length s19 sa30 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW full length
stoichiometric coefficient: 1.0

ncbitaxon 7227 7
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot A0A0B4K7J3 32
type: UnificationXref
id: A0A0B4K7J3
db: uniprot

MAD
type: Protein
entity reference: MAD
feature: MAD s79 sa58 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa58 158
feature: MAD s79 sa58 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAD
type: Protein
entity reference: MAD
feature: MAD s145 sa106 rs1
feature: MAD s145 sa106 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAD s145 sa106 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MAD s144 sa109 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa42 120
comment: SPECIES_TYPE=PROTEIN

MAD s129 sa101 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Evidence 43
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0086361.html

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

FUR1
type: Protein
entity reference: FUR1
cellular location: unknown c3
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re33 190
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 191
type: Stoichiometry
physical entity: sa105_degraded
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__MED__phosphoMAD-RIGHT__MED__phosphoMAD-_re27
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 260
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 259
left: MED/ phosphoMAD
interaction type: TRANSPORT
right: MED/ phosphoMAD

SCW s11 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

?
type: Protein

MAD
type: ProteinReference
xref: P06271
standard name: mothers against dpp
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.MAD
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein mothers against dpp

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__DPP_SCW_full_length-RIGHT__?-_proDPP_proSCW-_re4
controller: FUR1

PARTICIPANT STOICHIOMETRY re8 203
type: Stoichiometry
physical entity: DPP/proSCW
stoichiometric coefficient: 1.0

? s34 sa33 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

MAD s129 sa101 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MED/ phosphoMAD
type: Complex
component stoichiometry: DPP s96 sa82 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 37STOICHIOMETRY ID COMPLEX
component: MAD
component: MED
feature: COMPLEX BINDING FEATURE s107 csa20 83
feature: COMPLEX BINDING FEATURE s107 csa20 81
cellular location: cytosol

Evidence 18
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0029006.html

FUR1
type: Protein
entity reference: FUR1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

TKV
type: Protein
entity reference: TKV
feature: TKV s25 sa67 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa67 154
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re8 205
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

SCW s15 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__proDPP_proSCW-RIGHT__proDPP__proSCW-_re5
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 216
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 215
left: proDPP/proSCW
interaction type: TRANSPORT
right: proDPP/ proSCW

PARTICIPANT STOICHIOMETRY re8 204
type: Stoichiometry
physical entity: DPP/proSCW
stoichiometric coefficient: 1.0

DPP s33 sa32 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

HOMODIMER ID 38STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

PUT
type: Protein
entity reference: PUT

TRANSPORT_LEFT__MED-RIGHT__MED-_re28
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 257
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 258
left: MED
interaction type: TRANSPORT
right: MED

Target genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

TKV s73 sa54 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

MAD s139 sa111 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PUT s84 sa63 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SCW s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

?
type: Protein

HETERODIMER_ASSOCIATION_LEFT__DPP_proSCW-_SOG-_TSG-RIGHT__SOG_TSG_DPP_SCW-_re9
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 202
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 200
left: DPP/proSCW
left: SOG
left: TSG
interaction type: HETERODIMER_ASSOCIATION
right: SOG/TSG DPP/SCW

Evidence 28
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0000490.html

SHN/MED/ phosphoMAD
type: Complex
component stoichiometry: MED s116 sa99 STOICHIOMETRY ID COMPLEX
component stoichiometry: SHN s117 sa100 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 38STOICHIOMETRY ID COMPLEX
component: MED
component: SHN
component: MAD
feature: COMPLEX BINDING FEATURE s114 csa21 79
feature: COMPLEX BINDING FEATURE s114 csa21 77
feature: COMPLEX BINDING FEATURE s114 csa21 75
cellular location: nucleus

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s110 sa69 110
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Evidence 20
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0005590.html

Evidence 22
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0011655.html

proDPP/ proSCW
type: Complex
component stoichiometry: HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
component stoichiometry: SCW s36 sa35 STOICHIOMETRY ID COMPLEX
component stoichiometry: DPP s37 sa36 STOICHIOMETRY ID COMPLEX
component: SCW
component: DPP
component: ?
feature: COMPLEX BINDING FEATURE s35 csa8 147
feature: COMPLEX BINDING FEATURE s35 csa8 145
feature: COMPLEX BINDING FEATURE s35 csa8 149
cellular location: unknown c3

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s95 sa68 108
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

IDA
type: EvidenceCodeVocabulary

MED
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 sa82 84
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__MAD-_LACK-RIGHT__phosphoMAD_LACK-_re34
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 188
participant stoichiometry: PARTICIPANT STOICHIOMETRY re34 189
left: LACK
left: MAD
interaction type: HETERODIMER_ASSOCIATION
right: phosphoMAD LACK

MAD s139 sa111 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

SAX
type: Protein
entity reference: SAX
feature: SAX s69 sa51 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__MAD-RIGHT__MAD-_re18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 217
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 218
left: MAD
interaction type: STATE_TRANSITION
right: MAD

PARTICIPANT STOICHIOMETRY re14 242
type: Stoichiometry
physical entity: TKV/SAX
stoichiometric coefficient: 1.0

MAD s131 sa83 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re14 243
type: Stoichiometry
physical entity: TKV/SAX
stoichiometric coefficient: 1.0

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa9 186
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DPP s37 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

DPP s65 sa39 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

uniprot Q9VMT1 33
type: UnificationXref
id: Q9VMT1
db: uniprot

MAD s106 sa79 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

uniprot P54631 19
type: UnificationXref
id: P54631
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: PTHR42884:SF3
xref: uniprot P26016 41
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__MAD-RIGHT__sa105_degraded-_re33
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 191
left: MAD
interaction type: STATE_TRANSITION
right: sa105_degraded

SCW s53 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SCW
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer_MAD-_ATP-RIGHT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer_phosphoMAD-_ADP-_re16
controller: phosphoTKV/ phosphoSAX

SAX
type: Protein
entity reference: SAX
feature: SAX s92 sa15 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s92 sa15 60
comment: SPECIES_TYPE=PROTEIN

MED
type: ProteinReference
xref: P06265
standard name: medea
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.MED
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein mothers against dpp
member entity reference: Mothers against decapentaplegic homolog

TKV s93 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 1.0

SAX s72 sa53 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_TKV_SAX_DPP_SCW_PUT_dimer-RIGHT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer-_ADP-_re3
controller: PUT

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s141 sa112 134
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 34

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa17 68
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PUT
type: Protein
entity reference: PUT

GO GO:0005794 2
type: UnificationXref
id: GO:0005794
db: GO

phosphoTKV phosphoSAX s98 csa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: phosphoTKV/ phosphoSAX
stoichiometric coefficient: 1.0

?
type: Complex
component stoichiometry: ? s67 sa41 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa41 130
cellular location: unknown c3

HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MAD-_MED-_re26
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 262
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 261
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 263
left: MED/ phosphoMAD
interaction type: DISSOCIATION
right: MAD
right: MED

TKV
type: Protein
entity reference: TKV
feature: TKV s6 sa5 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 54
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Receptor protein serine/threonine kinase
type: ProteinReference
xref: PTHR23255:SF72
xref: uniprot A0A0B4K7J3 32
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re11 250
type: Stoichiometry
physical entity: TKV/SAX
stoichiometric coefficient: 1.0

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s53 sa47 166
comment: SPECIES_TYPE=PROTEIN

TRUNCATION_LEFT__DPP_SCW_full_length-RIGHT__?-_proDPP_proSCW-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 220
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 219
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 221
left: DPP/SCW full length
interaction type: TRUNCATION
right: proDPP/proSCW
right: ?

PDP
type: Protein
entity reference: PDP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

DPP s40 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

PUT s60 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

MAD s104 sa76 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

DPP
type: Protein
entity reference: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa32 176
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

DISSOCIATION_LEFT__DPP_proSCW-RIGHT__DPP_proSCW-_?-_re8
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 205
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 204
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 203
left: DPP/proSCW
interaction type: DISSOCIATION
right: DPP/proSCW
right: ?

MAD
type: Complex
component stoichiometry: MAD s115 sa98 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s115 sa98 76
cellular location: nucleus

DISSOCIATION_LEFT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer_phosphoMAD-RIGHT__MAD-_phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer-_re17
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 224
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 223
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 222
left: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer phosphoMAD
interaction type: DISSOCIATION
right: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer
right: MAD

NEJ
type: ProteinReference
xref: P06260
standard name: nejire
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.NEJ
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Nejire, isoform C

MAD
type: Complex
component stoichiometry: MAD s129 sa101 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s129 sa101 86
cellular location: nucleus

PARTICIPANT STOICHIOMETRY re11 249
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 248
type: Stoichiometry
physical entity: SAX
stoichiometric coefficient: 1.0

TKV s9 sa7 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.93

HETERODIMER_ASSOCIATION_LEFT__DPP_SCW_TKV_SAX-_PUT-RIGHT__TKV_SAX_DPP_SCW_PUT_dimer-_re2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 234
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 233
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 235
left: PUT
left: DPP/SCW TKV/SAX
interaction type: HETERODIMER_ASSOCIATION
right: TKV/SAX DPP/SCW PUT dimer

uniprot M9MS40 30
type: UnificationXref
id: M9MS40
db: uniprot

MAD s79 sa58 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MAD
type: Complex
component stoichiometry: MAD s120 sa103 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s120 sa103 140
cellular location: nucleus

phosphoTKV/ phosphoSAX DPP/SCW PUT dimer phosphoMAD
type: Complex
component stoichiometry: DPP s110 sa69 STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s99 sa70 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
component stoichiometry: SCW s95 sa68 STOICHIOMETRY ID COMPLEX
component stoichiometry: phosphoTKV phosphoSAX s98 csa19 STOICHIOMETRY ID COMPLEX
component: PUT
component: MAD
component: DPP
component: SCW
component: phosphoTKV/ phosphoSAX
feature: COMPLEX BINDING FEATURE s105 csa18 107
feature: COMPLEX BINDING FEATURE s105 csa18 111
feature: COMPLEX BINDING FEATURE s105 csa18 113
feature: COMPLEX BINDING FEATURE s105 csa18 109
feature: COMPLEX BINDING FEATURE s105 csa18 105
cellular location: cytosol

phosphoMAD LACK
type: Complex
component stoichiometry: MAD s144 sa109 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s143 sa110 STOICHIOMETRY ID COMPLEX
component: LACK
component: MAD
feature: COMPLEX BINDING FEATURE s142 csa24 135
feature: COMPLEX BINDING FEATURE s142 csa24 137
cellular location: cytosol

DPP/proSCW
type: Complex
component stoichiometry: DPP s2 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: SCW s3 sa3 STOICHIOMETRY ID COMPLEX
component: DPP
component: SCW
feature: COMPLEX BINDING FEATURE s1 csa1 117
feature: COMPLEX BINDING FEATURE s1 csa1 115

uniprot O62609 21
type: UnificationXref
id: O62609
db: uniprot

?
type: Complex
component stoichiometry: ? s43 sa23 STOICHIOMETRY ID COMPLEX
component: ?

MAD s131 sa83 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

?
type: Complex
component stoichiometry: ? s42 sa44 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s42 sa44 124

?
type: Complex
component stoichiometry: ? s38 sa37 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s38 sa37 150
cellular location: unknown c3

?
type: Complex
component stoichiometry: ? s34 sa33 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa33 178
cellular location: Golgi apparatus

?
type: Complex
component stoichiometry: ? s68 sa21 STOICHIOMETRY ID COMPLEX
component: ?
cellular location: unknown c3

PARTICIPANT STOICHIOMETRY re10 254
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

PANTHER Pathway P06212 1
type: UnificationXref
id: P06212
db: PANTHER Pathway

HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 4.0

MAD s115 sa98 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

unknown c3
type: CellularLocationVocabulary
comment: unknown

PARTICIPANT STOICHIOMETRY re10 253
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 252
type: Stoichiometry
physical entity: DPP/proSCW
stoichiometric coefficient: 1.0

DPP s54 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 1.0

? s68 sa21 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re10 251
type: Stoichiometry
physical entity: SOG/TSG DPP/SCW
stoichiometric coefficient: 1.0

PPM1A
type: Protein
entity reference: PPM1A
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAD
type: Complex
component stoichiometry: MAD s106 sa79 STOICHIOMETRY ID COMPLEX
component: MAD
cellular location: cytosol

HOMODIMER ID 14STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

MAD
type: Complex
component stoichiometry: MAD s109 sa81 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s109 sa81 82
cellular location: cytosol

Nejire, isoform C
type: ProteinReference
xref: uniprot M9MS40 30
xref: PTHR13808:SF1
organism: Drosophila melanogaster

STATE_TRANSITION
type: InteractionVocabulary

GM14286p
type: ProteinReference
xref: PTHR13832:SF571
xref: uniprot Q9W3Q1 24
organism: Drosophila melanogaster

TRANSPORT
type: InteractionVocabulary

DPP-SCW_signaling_pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__MED__phosphoMAD-_NEJ-RIGHT__NEJ_MED__phosphoMAD-_re22
pathway component: HETERODIMER_ASSOCIATION_LEFT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer-_MAD-RIGHT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer_MAD-_re15
pathway component: HETERODIMER_ASSOCIATION_LEFT__DPP_proSCW-_TKV_SAX-RIGHT__DPP_SCW_TKV_SAX-_re1
pathway component: STATE_TRANSITION_LEFT__ATP-_TKV_SAX_DPP_SCW_PUT_dimer-RIGHT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer-_ADP-_re3
pathway component: TRANSPORT_LEFT__proDPP_proSCW-RIGHT__proDPP__proSCW-_re5
pathway component: STATE_TRANSITION_LEFT__MAD-RIGHT__sa105_degraded-_re33
pathway component: DISSOCIATION_LEFT__SOG_TSG_DPP_SCW-RIGHT__DPP_proSCW-_SOG-_TSG-_re10
pathway component: DISSOCIATION_LEFT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer_phosphoMAD-RIGHT__MAD-_phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer-_re17
pathway component: HETERODIMER_ASSOCIATION_LEFT__MAD-_LACK-RIGHT__phosphoMAD_LACK-_re34
pathway component: TRANSPORT_LEFT__MAD-RIGHT__MAD-_re29
pathway component: STATE_TRANSITION_LEFT__MAD-RIGHT__MAD-_re18
pathway component: TRANSPORT_LEFT__MED__phosphoMAD-RIGHT__MED__phosphoMAD-_re27
pathway component: TRANSPORT_LEFT__MAD-RIGHT__MAD-_re30
pathway component: TRANSPORT_LEFT__PUT-RIGHT__PUT-_re13
pathway component: HETERODIMER_ASSOCIATION_LEFT__DPP_proSCW-_SOG-_TSG-RIGHT__SOG_TSG_DPP_SCW-_re9
pathway component: TRANSPORT_LEFT__TKV_SAX-RIGHT__TKV_SAX-_re14
pathway component: DISSOCIATION_LEFT__DPP_proSCW-RIGHT__DPP_proSCW-_?-_re8
pathway component: DISSOCIATION_LEFT__phosphoMAD_LACK-RIGHT__MAD-_LACK-_re32
pathway component: STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re12
pathway component: TRANSPORT_LEFT__MED-RIGHT__MED-_re28
pathway component: TRUNCATION_LEFT__proDPP__proSCW-RIGHT__DPP_proSCW-_?-_re6
pathway component: TRUNCATION_LEFT__DPP_SCW_full_length-RIGHT__?-_proDPP_proSCW-_re4
pathway component: STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re31
pathway component: HETERODIMER_ASSOCIATION_LEFT__DPP_SCW_TKV_SAX-_PUT-RIGHT__TKV_SAX_DPP_SCW_PUT_dimer-_re2
pathway component: STATE_TRANSITION_LEFT__MAD-_MED-RIGHT__MAD-_MED__phosphoMAD-_re19
pathway component: STATE_TRANSITION_LEFT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer_MAD-_ATP-RIGHT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer_phosphoMAD-_ADP-_re16
pathway component: HETERODIMER_ASSOCIATION_LEFT__SAX-_TKV-RIGHT__TKV_SAX-_re11
pathway component: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MAD-_MED-_re26
pathway component: HETERODIMER_ASSOCIATION_LEFT__MED__phosphoMAD-_SHN-RIGHT__SHN_MED__phosphoMAD-_re21
pathway component: TRANSPORT_LEFT__DPP_proSCW-RIGHT__DPP_proSCW-_re7
xref: PANTHER Pathway P06212 1
comment: MODEL_NOTES=

SAX
type: Protein
entity reference: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s21 sa66 152
feature: SAX s21 sa66 rs1
comment: SPECIES_TYPE=PROTEIN

MED
type: Protein
entity reference: MED
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

TRUNCATION
type: InteractionVocabulary

SAX s72 sa53 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.53

SCW
type: Protein
entity reference: SCW
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa43 122
comment: SPECIES_TYPE=PROTEIN

TLD
type: ProteinReference
xref: P06264
standard name: tolloid
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.TLD
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dorsal-ventral patterning protein tolloid

SCW full length
type: ProteinReference
xref: P06275
standard name: screw
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.GENERIC.SCW_br_full length
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein screw

MAD s79 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

MAD s115 sa98 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

SAX
type: Protein
entity reference: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa10 90
feature: SAX s14 sa10 rs1
comment: SPECIES_TYPE=PROTEIN

PUT
type: Complex
component stoichiometry: PUT s97 sa71 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s97 sa71 114
cellular location: cytosol

MAD s104 sa76 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.18
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

DPP full length s30 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP full length
stoichiometric coefficient: 1.0

SCW full length
type: Protein
entity reference: SCW full length
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa30 74
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

Protein screw
type: ProteinReference
evidence: Evidence 20
xref: PTHR11848:SF263
xref: uniprot P54631 19
organism: Drosophila melanogaster

TRANSPORT_LEFT__MAD-RIGHT__MAD-_re29
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 255
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 256
left: MAD
interaction type: TRANSPORT
right: MAD

TRANSPORT_LEFT__DPP_proSCW-RIGHT__DPP_proSCW-_re7
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 207
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 206
left: DPP/proSCW
interaction type: TRANSPORT
right: DPP/proSCW

E3 ubiquitin-protein ligase Smurf1
type: ProteinReference
evidence: Evidence 18
xref: uniprot Q9V853 17
xref: PTHR11254:SF395
organism: Drosophila melanogaster

Schnurri, isoform F
type: ProteinReference
xref: uniprot A0A0B4KFC0 26
xref: PTHR45944:SF2
organism: Drosophila melanogaster

DPP s96 sa82 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PTHR45944:SF2
type: RelationshipXref
id: PTHR45944:SF2
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re32 193
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 194
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 192
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

PUT
type: Complex
component stoichiometry: PUT s12 sa1 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: cytosol

uniprot P54356 35
type: UnificationXref
id: P54356
db: uniprot

PUT
type: Complex
component stoichiometry: PUT s75 sa56 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: endoplasmic reticulum

TKV s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 1.0

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 31

PUT
type: Complex
component stoichiometry: PUT s24 sa19 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa19 70
cellular location: cytosol

NEJ
type: Protein
entity reference: NEJ
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PUT
type: Complex
component stoichiometry: PUT s60 sa14 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa14 100
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s84 sa63 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s84 sa63 164
cellular location: cytosol

HOMODIMER ID 49STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

SAX s92 sa15 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.53

HETERODIMER_ASSOCIATION_LEFT__MED__phosphoMAD-_NEJ-RIGHT__NEJ_MED__phosphoMAD-_re22
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 265
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 266
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 264
left: MED/ phosphoMAD
left: NEJ
interaction type: HETERODIMER_ASSOCIATION
right: NEJ/MED/ phosphoMAD

PARTICIPANT STOICHIOMETRY re3 226
type: Stoichiometry
physical entity: TKV/SAX DPP/SCW PUT dimer
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 246
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 247
left: PUT
interaction type: STATE_TRANSITION
right: PUT

PARTICIPANT STOICHIOMETRY re3 225
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 9.0

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

DPP
type: ProteinReference
xref: P06272
standard name: decapentaplegic
comment: ENTITY_REFERENCE_ID_DESC=DPP-SCW_signaling_pathway.PROTEIN.TRUNCATED.DPP
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein decapentaplegic

PARTICIPANT STOICHIOMETRY re3 228
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 9.0

PARTICIPANT STOICHIOMETRY re3 227
type: Stoichiometry
physical entity: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re31
controller: LACK

SAX
type: Protein
entity reference: SAX
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa6 180
feature: SAX s8 sa6 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9V853 17
type: UnificationXref
id: Q9V853
db: uniprot

PARTICIPANT STOICHIOMETRY re9 199
type: Stoichiometry
physical entity: DPP/proSCW
stoichiometric coefficient: 1.0

HOMODIMER ID 13STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re34 189
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

TRUNCATION_LEFT__proDPP__proSCW-RIGHT__DPP_proSCW-_?-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 208
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 210
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 209
left: proDPP/ proSCW
interaction type: TRUNCATION
right: DPP/proSCW
right: ?

PARTICIPANT STOICHIOMETRY re34 188
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

SHN
type: Protein
entity reference: SHN
feature: COMPLEX PARTICIPANT BINDING FEATURE s117 sa100 80
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__MAD-RIGHT__MAD-_re30
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY re30 197
left: MAD
interaction type: TRANSPORT
right: MAD

PARTICIPANT STOICHIOMETRY re34 187
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer_MAD-_ATP-RIGHT__phosphoTKV__phosphoSAX_DPP_SCW_PUT_dimer_phosphoMAD-_ADP-_re16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 229
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 232
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 231
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 230
left: ATP
left: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer MAD
interaction type: STATE_TRANSITION
right: ADP
right: phosphoTKV/ phosphoSAX DPP/SCW PUT dimer phosphoMAD

PUT s75 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

Alphabet, isoform E
type: ProteinReference
evidence: Evidence 43
xref: PTHR47992:SF25
xref: uniprot Q961C5 42
organism: Drosophila melanogaster