TKV
type: Protein
entity reference: TKV
feature: TKV s64 sa46 rs1

PARTICIPANT STOICHIOMETRY re37 153
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re37 152
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

HOMODIMER ID 51STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

uniprot Q5U110 61
type: UnificationXref
id: Q5U110
db: uniprot

TRANSPORT_LEFT__DPP-RIGHT__DPP-_re11
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 204
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 203
left: DPP
interaction type: TRANSPORT
right: DPP

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

HETERODIMER_ASSOCIATION_LEFT__MED__phosphoMAD-_NEJ-RIGHT__NEJ_MED__phosphoMAD-_re28
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 216
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 215
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 217
left: NEJ
left: MED/ phosphoMAD
interaction type: HETERODIMER_ASSOCIATION
right: NEJ/MED/ phosphoMAD

Evidence 19
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0029006.html

Evidence 9
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0003169.html

Protein twisted gastrulation
type: ProteinReference
xref: PTHR12312:SF16
xref: uniprot P54356 52
organism: Drosophila melanogaster

Evidence 26
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0000490.html

SOG
type: Protein
entity reference: SOG
feature: COMPLEX PARTICIPANT BINDING FEATURE s50 sa37 116
comment: SPECIES_TYPE=PROTEIN

DPP s126 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

Evidence 21
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0011655.html

PARTICIPANT STOICHIOMETRY re28 217
type: Stoichiometry
physical entity: NEJ/MED/ phosphoMAD
stoichiometric coefficient: 1.0

HOMODIMER ID 39STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

PPM1A
type: ProteinReference
xref: P06289
standard name: protein phosphatase 2C alpha, beta
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.PPM1A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Alphabet, isoform E

SHN s109 sa77 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SHN
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 216
type: Stoichiometry
physical entity: NEJ
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 215
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

TKV s64 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__MED-RIGHT__MED-_re33
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 156
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 157
left: MED
interaction type: TRANSPORT
right: MED

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 7

MED s96 sa71 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PTHR13703:SF61
type: RelationshipXref
id: PTHR13703:SF61
db: PANTHER Family
relationship type: By Homology

MED
type: ProteinReference
xref: P06279
standard name: medea
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.MED
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein mothers against dpp
member entity reference: Mothers against decapentaplegic homolog

TRUNCATION_LEFT__DPP_full_length-RIGHT__?-_DPP-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 172
left: DPP full length
interaction type: TRUNCATION
right: DPP
right: ?

HETERODIMER_ASSOCIATION_LEFT__phosphoTKV__DPP_PUT-_MAD-RIGHT__PUT_DPP_phosphoTKV_MAD-_re17
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 174
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 173
left: phosphoTKV/ DPP/PUT
left: MAD
interaction type: HETERODIMER_ASSOCIATION
right: PUT/DPP phosphoTKV MAD

MAD
type: Protein
entity reference: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s79 sa58 132
feature: MAD s79 sa58 rs2
feature: MAD s79 sa58 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__SOG-_TSG-_DPP-RIGHT__SOG_TSG_DPP_dimer-_re10
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 207
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 209
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 208
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 210
left: TSG
left: DPP
left: SOG
interaction type: HETERODIMER_ASSOCIATION
right: SOG/TSG DPP dimer

uniprot P26016 58
type: UnificationXref
id: P26016
db: uniprot

STATE_TRANSITION_LEFT__TKV-RIGHT__TKV-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 192
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 193
left: TKV
interaction type: STATE_TRANSITION
right: TKV

HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

TKV s130 sa96 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

NEJ
type: Protein
entity reference: NEJ
feature: COMPLEX PARTICIPANT BINDING FEATURE s115 sa81 102
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q961C5 59
type: UnificationXref
id: Q961C5
db: uniprot

MAD s140 sa101 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s143 sa104 96
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PDP
type: ProteinReference
xref: P06280
standard name: pyruvate dehydrogenase phosphatase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.PDP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: GM14286p

PTHR47992:SF25
type: RelationshipXref
id: PTHR47992:SF25
db: PANTHER Family
relationship type: By Homology

HOMODIMER ID 64STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

TKV
type: Protein
entity reference: TKV
feature: TKV s13 sa5 rs1

uniprot P25723 28
type: UnificationXref
id: P25723
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_TKV_DPP__PUT-RIGHT__phosphoTKV__DPP_PUT-_ADP-_re3
controller: PUT

SOG
type: ProteinReference
xref: P06293
standard name: short gastrulation
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.SOG
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dorsal-ventral patterning protein Sog

TKV s125 sa10 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

PTHR13703:SF45
type: RelationshipXref
id: PTHR13703:SF45
db: PANTHER Family
relationship type: By Homology

HOMODIMER ID 41STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re13 193
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re17 173
type: Stoichiometry
physical entity: phosphoTKV/ DPP/PUT
stoichiometric coefficient: 1.0

MAD s140 sa101 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

STATE_TRANSITION_LEFT__MAD-_MED-RIGHT__MAD-_MED__phosphoMAD-_re40
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 214
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 212
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 211
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 213
left: MED
left: MAD
interaction type: STATE_TRANSITION
right: MED/ phosphoMAD
right: MAD

PARTICIPANT STOICHIOMETRY re17 174
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 175
type: Stoichiometry
physical entity: PUT/DPP phosphoTKV MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 192
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__ATP-_TKV_DPP__PUT-RIGHT__phosphoTKV__DPP_PUT-_ADP-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 179
left: TKV/DPP/ PUT
left: ATP
interaction type: STATE_TRANSITION
right: phosphoTKV/ DPP/PUT
right: ADP

MAD
type: Protein
entity reference: MAD
feature: MAD s67 sa48 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s67 sa48 148
feature: MAD s67 sa48 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__phosphoTKV__DPP_PUT-_DAD-RIGHT__phosphoTKV__DPP_PUT_DAD-_re38
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 151
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 150
participant stoichiometry: PARTICIPANT STOICHIOMETRY re38 149
left: DAD
left: phosphoTKV/ DPP/PUT
interaction type: HETERODIMER_ASSOCIATION
right: phosphoTKV/ DPP/PUT DAD

DPP s10 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

MAD s67 sa48 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

P06279
type: UnificationXref
id: P06279
db: PANTHER Pathway Component

P06277
type: UnificationXref
id: P06277
db: PANTHER Pathway Component

P06278
type: UnificationXref
id: P06278
db: PANTHER Pathway Component

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s114 sa79 100
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

phosphoTKV/ DPP/PUT
type: Complex
component stoichiometry: HOMODIMER ID 16STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 50STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 40STOICHIOMETRY ID COMPLEX
component: TKV
component: DPP
component: PUT
feature: COMPLEX BINDING FEATURE s88 csa3 109
feature: COMPLEX BINDING FEATURE s88 csa3 107
feature: COMPLEX BINDING FEATURE s88 csa3 111
cellular location: cytosol

Evidence 62
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0020493.html

PTHR13703:SF54
type: RelationshipXref
id: PTHR13703:SF54
db: PANTHER Family
relationship type: By Homology

Evidence 60
type: Evidence
evidence code: IEA
comment: Website http://flybase.org/reports/FBgn0086361.html

sa105_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

?
type: Protein

PARTICIPANT STOICHIOMETRY re3 176
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 8.0

PARTICIPANT STOICHIOMETRY re3 177
type: Stoichiometry
physical entity: TKV/DPP/ PUT
stoichiometric coefficient: 1.0

uniprot Q24025 66
type: UnificationXref
id: Q24025
db: uniprot

HOMODIMER ID 50STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

P06280
type: UnificationXref
id: P06280
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re3 179
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 8.0

DPP s14 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

P06282
type: UnificationXref
id: P06282
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re3 178
type: Stoichiometry
physical entity: phosphoTKV/ DPP/PUT
stoichiometric coefficient: 1.0

P06283
type: UnificationXref
id: P06283
db: PANTHER Pathway Component

ADP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

P06284
type: UnificationXref
id: P06284
db: PANTHER Pathway Component

PTHR11848:SF54
type: RelationshipXref
id: PTHR11848:SF54
db: PANTHER Family
relationship type: By Homology

P06285
type: UnificationXref
id: P06285
db: PANTHER Pathway Component

P06286
type: UnificationXref
id: P06286
db: PANTHER Pathway Component

P06287
type: UnificationXref
id: P06287
db: PANTHER Pathway Component

HETERODIMER_ASSOCIATION_LEFT__DPP-_TKV-RIGHT__DPP_dimer__TKV-_re1
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 188
left: TKV
left: DPP
interaction type: HETERODIMER_ASSOCIATION
right: DPP dimer/ TKV

P06288
type: UnificationXref
id: P06288
db: PANTHER Pathway Component

P06289
type: UnificationXref
id: P06289
db: PANTHER Pathway Component

MED
type: Protein
entity reference: MED
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAD s144 sa103 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAD s144 sa103 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

HOMODIMER ID 35STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

Golgi apparatus
type: CellularLocationVocabulary
xref: GO GO:0005794 2

MED
type: Protein
entity reference: MED
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__proDPP-RIGHT__DPP-_?-_re6
controller: FUR1

PARTICIPANT STOICHIOMETRY re24 221
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re24 222
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

phosphoTKV/ DPP/PUT DAD
type: Complex
component stoichiometry: DAD s132 sa99 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 41STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 17STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 51STOICHIOMETRY ID COMPLEX
component: DPP
component: TKV
component: PUT
component: DAD
feature: COMPLEX BINDING FEATURE s133 csa16 83
feature: COMPLEX BINDING FEATURE s133 csa16 81
feature: COMPLEX BINDING FEATURE s133 csa16 87
feature: COMPLEX BINDING FEATURE s133 csa16 85
cellular location: cytosol

NEJ s115 sa81 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: NEJ
stoichiometric coefficient: 1.0

MAD s67 sa48 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

TKV s13 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

MED s100 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

HOMODIMER ID 38STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

Dorsal-ventral patterning protein Sog
type: ProteinReference
xref: PTHR46526:SF1
xref: uniprot Q24025 66
organism: Drosophila melanogaster

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 5

PTHR13832:SF571
type: RelationshipXref
id: PTHR13832:SF571
db: PANTHER Family
relationship type: By Homology

uniprot M9MS40 29
type: UnificationXref
id: M9MS40
db: uniprot

? s23 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

TRUNCATION
type: RelationshipTypeVocabulary

MAD
type: Protein
entity reference: MAD
feature: MAD s145 sa105 rs2
feature: MAD s145 sa105 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GO GO:0005794 2
type: UnificationXref
id: GO:0005794
db: GO

uniprot A0A0B4KG59 6
type: UnificationXref
id: A0A0B4KG59
db: uniprot

PUT s61 sa43 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

MAD s67 sa48 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

DPP
type: Protein
entity reference: DPP

MAD s93 sa70 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MAD s62 sa44 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TKV
type: Complex
component stoichiometry: TKV s125 sa10 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s125 sa10 110
cellular location: cytosol

MAD s107 sa75 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

PUT s5 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

MAD
type: Complex
component stoichiometry: MAD s99 sa66 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s99 sa66 74
cellular location: cytosol

MAD
type: Complex
component stoichiometry: MAD s92 sa65 STOICHIOMETRY ID COMPLEX
component: MAD
cellular location: cytosol

TKV
type: Complex
component stoichiometry: TKV s130 sa96 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s130 sa96 84
cellular location: cytosol

MAD
type: Complex
component stoichiometry: MAD s113 sa78 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s113 sa78 98
cellular location: nucleus

MAD
type: Complex
component stoichiometry: MAD s107 sa75 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s107 sa75 68
cellular location: nucleus

MAD
type: Complex
component stoichiometry: MAD s93 sa70 STOICHIOMETRY ID COMPLEX
component: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s93 sa70 78
cellular location: nucleus

TKV
type: Protein
entity reference: TKV
feature: TKV s8 sa8 rs1

TKV
type: Complex
component stoichiometry: TKV s64 sa46 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s64 sa46 144
cellular location: cytosol

TKV
type: Complex
component stoichiometry: TKV s77 sa56 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 sa56 128
cellular location: cytosol

FUR1
type: Protein
entity reference: FUR1
cellular location: unknown c3
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re6 161
type: Stoichiometry
physical entity: proDPP
stoichiometric coefficient: 1.0

proDPP
type: Complex
component stoichiometry: HOMODIMER ID 65STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 36STOICHIOMETRY ID COMPLEX
component: DPP
component: ?
feature: COMPLEX BINDING FEATURE s33 csa4 139
feature: COMPLEX BINDING FEATURE s33 csa4 137
cellular location: Golgi apparatus

PARTICIPANT STOICHIOMETRY re6 163
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

DPP
type: Protein
entity reference: DPP

PARTICIPANT STOICHIOMETRY re6 162
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re12 197
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__MAD-RIGHT__MAD-_re37
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 153
participant stoichiometry: PARTICIPANT STOICHIOMETRY re37 152
left: MAD
interaction type: TRANSPORT
right: MAD

PARTICIPANT STOICHIOMETRY re12 196
type: Stoichiometry
physical entity: SOG/TSG DPP dimer
stoichiometric coefficient: 1.0

DPP full length
type: Protein
entity reference: DPP full length

SOG/TSG DPP dimer
type: Complex
component stoichiometry: TSG s51 sa38 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 37STOICHIOMETRY ID COMPLEX
component stoichiometry: SOG s50 sa37 STOICHIOMETRY ID COMPLEX
component: DPP
component: TSG
component: SOG
feature: COMPLEX BINDING FEATURE s48 csa8 117
feature: COMPLEX BINDING FEATURE s48 csa8 115
feature: COMPLEX BINDING FEATURE s48 csa8 113

TRANSPORT_LEFT__MAD-RIGHT__MAD-_re36
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 155
participant stoichiometry: PARTICIPANT STOICHIOMETRY re36 154
left: MAD
interaction type: TRANSPORT
right: MAD

MAD s93 sa70 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

DPP
type: Complex
component stoichiometry: DPP s131 sa97 STOICHIOMETRY ID COMPLEX
component: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s131 sa97 86
cellular location: cytosol

MAD
type: Protein
entity reference: MAD
feature: MAD s62 sa44 rs1
feature: MAD s62 sa44 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DPP
type: Complex
component stoichiometry: DPP s126 sa11 STOICHIOMETRY ID COMPLEX
component: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s126 sa11 112
cellular location: cytosol

PTHR46526:SF1
type: RelationshipXref
id: PTHR46526:SF1
db: PANTHER Family
relationship type: By Homology

00696
type: UnificationXref
id: MOD:00696
db: mod

TKV
type: Complex
component stoichiometry: TKV s58 sa41 STOICHIOMETRY ID COMPLEX
component: TKV
cellular location: endoplasmic reticulum

TKV
type: Complex
component stoichiometry: TKV s9 sa2 STOICHIOMETRY ID COMPLEX
component: TKV
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re12 199
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

TKV
type: Complex
component stoichiometry: TKV s13 sa5 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa5 122
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re12 198
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

TKV
type: Complex
component stoichiometry: TKV s8 sa8 STOICHIOMETRY ID COMPLEX
component: TKV
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa8 106
cellular location: cytosol

DPP
type: Complex
component stoichiometry: DPP s49 sa36 STOICHIOMETRY ID COMPLEX
component: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa36 114

DPP
type: Complex
component stoichiometry: DPP s69 sa47 STOICHIOMETRY ID COMPLEX
component: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s69 sa47 146
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re10 210
type: Stoichiometry
physical entity: SOG/TSG DPP dimer
stoichiometric coefficient: 1.0

DPP
type: Complex
component stoichiometry: DPP s78 sa57 STOICHIOMETRY ID COMPLEX
component: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s78 sa57 130
cellular location: cytosol

IEA
type: EvidenceCodeVocabulary
xref: eco ECO:0000501 8

DPP s32 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

MAD s118 sa89 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9VMT1 42
type: UnificationXref
id: Q9VMT1
db: uniprot

PARTICIPANT STOICHIOMETRY re10 208
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 209
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__PUT-RIGHT__PUT-_re16
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 180
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 181
left: PUT
interaction type: TRANSPORT
right: PUT

DPP dimer/ TKV
type: Complex
component stoichiometry: HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
component: TKV
component: DPP
feature: COMPLEX BINDING FEATURE s6 csa2 105
feature: COMPLEX BINDING FEATURE s6 csa2 103
cellular location: cytosol

GO GO:0005783 5
type: UnificationXref
id: GO:0005783
db: GO

TKV
type: Protein
entity reference: TKV
feature: TKV s59 sa39 rs1
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

PTHR23255:SF98
type: RelationshipXref
id: PTHR23255:SF98
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re10 207
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

MAD
type: Protein
entity reference: MAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s144 sa103 94
feature: MAD s144 sa103 rs1
feature: MAD s144 sa103 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAD
type: Protein
entity reference: MAD
feature: MAD s93 sa70 rs1
feature: MAD s93 sa70 rs2

Receptor protein serine/threonine kinase
type: ProteinReference
xref: uniprot Q9VMT1 42
xref: PTHR23255:SF68
organism: Drosophila melanogaster

uniprot O62609 20
type: UnificationXref
id: O62609
db: uniprot

MAD s113 sa78 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

?
type: Complex
component stoichiometry: ? s27 sa15 STOICHIOMETRY ID COMPLEX
component: ?
cellular location: unknown c3

MAD
type: Protein
entity reference: MAD
feature: MAD s118 sa89 rs2
feature: MAD s118 sa89 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

?
type: Complex
component stoichiometry: ? s35 sa18 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa18 140
cellular location: Golgi apparatus

PTHR45645:SF8
type: RelationshipXref
id: PTHR45645:SF8
db: PANTHER Family
relationship type: By Homology

?
type: Complex
component stoichiometry: ? s23 sa19 STOICHIOMETRY ID COMPLEX
component: ?
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa19 134
cellular location: unknown c3

PARTICIPANT STOICHIOMETRY re26 220
type: Stoichiometry
physical entity: SHN/MED/ phosphoMAD
stoichiometric coefficient: 1.0

TKV s8 sa8 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

Protein mothers against dpp
type: ProteinReference
xref: uniprot P42003 22
xref: PTHR13703:SF61
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re1 187
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

LACK
type: ProteinReference
xref: P06278
standard name: lethal with a checkpoint kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.LACK
comment: ENTITY_REFERENCE_NOTES=
member entity reference: E3 ubiquitin-protein ligase Smurf1

PARTICIPANT STOICHIOMETRY re1 188
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re1 189
type: Stoichiometry
physical entity: DPP dimer/ TKV
stoichiometric coefficient: 1.0

unknown c3
type: CellularLocationVocabulary
comment: unknown

PARTICIPANT STOICHIOMETRY re26 218
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 219
type: Stoichiometry
physical entity: SHN
stoichiometric coefficient: 1.0

MED s108 sa76 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PUT
type: Complex
component stoichiometry: PUT s12 sa4 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa4 120
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s68 sa45 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s68 sa45 142
cellular location: cytosol

Protein decapentaplegic
type: ProteinReference
evidence: Evidence 26
xref: uniprot P07713 25
xref: PTHR11848:SF54
organism: Drosophila melanogaster

PUT
type: Complex
component stoichiometry: PUT s5 sa1 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s61 sa43 STOICHIOMETRY ID COMPLEX
component: PUT
cellular location: endoplasmic reticulum

TKV s58 sa41 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re41 205
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 156
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 157
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MED-_MAD-_re32
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 158
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 160
participant stoichiometry: PARTICIPANT STOICHIOMETRY re32 159
left: MED/ phosphoMAD
interaction type: DISSOCIATION
right: MED
right: MAD

PARTICIPANT STOICHIOMETRY re41 206
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

PUT
type: ProteinReference
xref: P06277
standard name: punt
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.RECEPTOR.PUT
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Serine/threonine-protein kinase receptor

STATE_TRANSITION
type: RelationshipTypeVocabulary

MAD s107 sa75 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re38 149
type: Stoichiometry
physical entity: phosphoTKV/ DPP/PUT
stoichiometric coefficient: 1.0

MED/ phosphoMAD
type: Complex
component stoichiometry: MED s96 sa71 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 55STOICHIOMETRY ID COMPLEX
component: MED
component: MAD
feature: COMPLEX BINDING FEATURE s98 csa13 77
feature: COMPLEX BINDING FEATURE s98 csa13 79
cellular location: nucleus

NEJ
type: ProteinReference
xref: P06284
standard name: nejire
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.NEJ
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Nejire, isoform C

DPP s34 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re14 191
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re14 190
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re39 229
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

LACK s143 sa104 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

eco ECO:0000316 30
type: UnificationXref
id: ECO:0000316
db: eco

PARTICIPANT STOICHIOMETRY re39 228
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

MAD s93 sa70 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s96 sa71 80
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

DPP
type: Complex
component stoichiometry: DPP s22 sa20 STOICHIOMETRY ID COMPLEX
component: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s22 sa20 136
cellular location: unknown c3

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 21
xref: PTHR13703:SF45
xref: uniprot O62609 20
organism: Drosophila melanogaster

TKV
type: Protein
entity reference: TKV
feature: TKV s125 sa10 rs1

DPP
type: Complex
component stoichiometry: DPP s34 sa17 STOICHIOMETRY ID COMPLEX
component: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s34 sa17 138
cellular location: Golgi apparatus

DPP
type: Complex
component stoichiometry: DPP s7 sa7 STOICHIOMETRY ID COMPLEX
component: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa7 104
cellular location: cytosol

DPP
type: Complex
component stoichiometry: DPP s14 sa6 STOICHIOMETRY ID COMPLEX
component: DPP
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa6 124
cellular location: cytosol

SHN
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s109 sa77 72
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

DPP
type: Complex
component stoichiometry: DPP s10 sa3 STOICHIOMETRY ID COMPLEX
component: DPP

DAD
type: Protein
entity reference: DAD
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DPP
type: Complex
component stoichiometry: DPP s32 sa16 STOICHIOMETRY ID COMPLEX
component: DPP
cellular location: unknown c3

MAD s83 sa64 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

HOMODIMER ID 33STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

MAD s113 sa78 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re39 230
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

DPP
type: Protein
entity reference: DPP

DPP s78 sa57 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re40 214
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

PUT
type: Protein
entity reference: PUT

DISSOCIATION_LEFT__phosphoMAD_LACK-RIGHT__LACK-_MAD-_re42
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 200
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 201
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 202
left: phosphoMAD LACK
interaction type: DISSOCIATION
right: MAD
right: LACK

MAD s118 sa89 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

HOMODIMER ID 34STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

TKV
type: Protein
entity reference: TKV
feature: TKV s58 sa41 rs1

TKV s130 sa96 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

TKV s9 sa2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

PARTICIPANT STOICHIOMETRY re40 211
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

Serine/threonine-protein kinase receptor
type: ProteinReference
evidence: Evidence 9
xref: PTHR23255:SF98
xref: uniprot A0A0B4KG59 6
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re40 213
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

DPP full length
type: Complex
component stoichiometry: DPP full length s20 sa13 STOICHIOMETRY ID COMPLEX
component: DPP full length
cellular location: Golgi apparatus

PARTICIPANT STOICHIOMETRY re40 212
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re38 151
type: Stoichiometry
physical entity: phosphoTKV/ DPP/PUT DAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re38 150
type: Stoichiometry
physical entity: DAD
stoichiometric coefficient: 1.0

MAD
type: Protein
entity reference: MAD
feature: MAD s140 sa101 rs1
feature: MAD s140 sa101 rs2
feature: COMPLEX PARTICIPANT BINDING FEATURE s140 sa101 90
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DPP full length
type: ProteinReference
xref: P06282
standard name: decapentaplegic
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.DPP_br_full length
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein decapentaplegic

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MED-_MAD-_re32
controller: PPM1A

TKV s8 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

DPP
type: Protein
entity reference: DPP

Target transcripts
type: RnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=RNA

MAD s113 sa78 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__SOG_TSG_DPP_dimer-RIGHT__SOG-_TSG-_DPP-_re12
controller: TLD

STATE_TRANSITION_LEFT__ATP-_PUT_DPP_phosphoTKV_MAD-RIGHT__ADP-_PUT_DPP_phosphoTKV_phosphoMAD-_re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 164
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 166
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 167
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 165
left: PUT/DPP phosphoTKV MAD
left: ATP
interaction type: STATE_TRANSITION
right: PUT/DPP phosphoTKV phosphoMAD
right: ADP

MAD
type: Protein
entity reference: MAD
feature: MAD s99 sa66 rs2
feature: MAD s99 sa66 rs1

DPP
type: Protein
entity reference: DPP

HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

MAD s107 sa75 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PUT
type: Complex
component stoichiometry: PUT s124 sa9 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s124 sa9 108
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s76 sa55 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s76 sa55 126
cellular location: cytosol

PUT
type: Complex
component stoichiometry: PUT s129 sa95 STOICHIOMETRY ID COMPLEX
component: PUT
feature: COMPLEX PARTICIPANT BINDING FEATURE s129 sa95 82
cellular location: cytosol

HOMODIMER ID 37STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

PDP
type: Protein
entity reference: PDP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

TLD
type: Protein
entity reference: TLD
comment: SPECIES_TYPE=PROTEIN

MED/ phosphoMAD
type: Complex
component stoichiometry: MED s100 sa68 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 54STOICHIOMETRY ID COMPLEX
component: MED
component: MAD
feature: COMPLEX BINDING FEATURE s97 csa12 75
feature: COMPLEX BINDING FEATURE s97 csa12 73
cellular location: cytosol

Dorsal-ventral patterning protein tolloid
type: ProteinReference
xref: PTHR45645:SF8
xref: uniprot P25723 28
organism: Drosophila melanogaster

PTHR11254:SF395
type: RelationshipXref
id: PTHR11254:SF395
db: PANTHER Family
relationship type: By Homology

PUT/DPP phosphoTKV phosphoMAD
type: Complex
component stoichiometry: HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 49STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 39STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s79 sa58 STOICHIOMETRY ID COMPLEX
component: DPP
component: PUT
component: MAD
component: TKV
feature: COMPLEX BINDING FEATURE s80 csa10 131
feature: COMPLEX BINDING FEATURE s80 csa10 129
feature: COMPLEX BINDING FEATURE s80 csa10 127
feature: COMPLEX BINDING FEATURE s80 csa10 125
cellular location: cytosol

TRANSPORT
type: RelationshipTypeVocabulary

MAD s83 sa64 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__DPP_full_length-RIGHT__?-_DPP-_re4
controller: FUR1

NEJ
type: Protein
entity reference: NEJ
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re22 224
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re22 223
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

TKV
type: Protein
entity reference: TKV
feature: TKV s77 sa56 rs1

DPP
type: Protein
entity reference: DPP

uniprot P54356 52
type: UnificationXref
id: P54356
db: uniprot

LACK
type: Protein
entity reference: LACK
feature: COMPLEX PARTICIPANT BINDING FEATURE s141 sa102 92
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

MAD s92 sa65 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TKV s77 sa56 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

PUT
type: Protein
entity reference: PUT

PUT
type: Protein
entity reference: PUT

DPP full length s20 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP full length
stoichiometric coefficient: 2.0

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

TLD
type: ProteinReference
xref: P06283
standard name: tolloid
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.TLD
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Dorsal-ventral patterning protein tolloid

MAD s79 sa58 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

MAD s144 sa103 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

DPP s69 sa47 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

MAD
type: Protein
entity reference: MAD
feature: MAD s92 sa65 rs1
feature: MAD s92 sa65 rs2

STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 185
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 186
left: PUT
interaction type: STATE_TRANSITION
right: PUT

DPP
type: Protein
entity reference: DPP

MAD s92 sa65 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

HOMODIMER ID 56STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

TKV s77 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re42 200
type: Stoichiometry
physical entity: phosphoMAD LACK
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__MED__phosphoMAD-RIGHT__MED__phosphoMAD-_re24
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 222
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 221
left: MED/ phosphoMAD
interaction type: TRANSPORT
right: MED/ phosphoMAD

uniprot Q9V853 18
type: UnificationXref
id: Q9V853
db: uniprot

PARTICIPANT STOICHIOMETRY re16 181
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re16 180
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_PUT_DPP_phosphoTKV_MAD-RIGHT__ADP-_PUT_DPP_phosphoTKV_phosphoMAD-_re19
controller: TKV

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

TKV s59 sa39 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

PARTICIPANT STOICHIOMETRY re42 202
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PTHR13808:SF1
type: RelationshipXref
id: PTHR13808:SF1
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re42 201
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re36 155
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re36 154
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PTHR12312:SF16
type: RelationshipXref
id: PTHR12312:SF16
db: PANTHER Family
relationship type: By Homology

DPP s7 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

DAD
type: Protein
entity reference: DAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s132 sa99 88
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000501 8
type: UnificationXref
id: ECO:0000501
db: eco

PARTICIPANT STOICHIOMETRY re15 185
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 1.0

MAD
type: Protein
entity reference: MAD
feature: MAD s83 sa64 rs1
feature: MAD s83 sa64 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re15 186
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

SOG s50 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOG
stoichiometric coefficient: 1.0

PTHR23255:SF68
type: RelationshipXref
id: PTHR23255:SF68
db: PANTHER Family
relationship type: By Homology

PUT s129 sa95 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

HOMODIMER ID 13STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

DAD s132 sa99 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DAD
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re41
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 206
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 205
left: phosphoMAD LACK
interaction type: STATE_TRANSITION
right: phosphoMAD LACK

PUT
type: Protein
entity reference: PUT

DISSOCIATION
type: InteractionVocabulary

?
type: Protein

NEJ/MED/ phosphoMAD
type: Complex
component stoichiometry: HOMODIMER ID 57STOICHIOMETRY ID COMPLEX
component stoichiometry: NEJ s115 sa81 STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s114 sa79 STOICHIOMETRY ID COMPLEX
component: MED
component: MAD
component: NEJ
feature: COMPLEX BINDING FEATURE s116 csa15 99
feature: COMPLEX BINDING FEATURE s116 csa15 101
feature: COMPLEX BINDING FEATURE s116 csa15 97
cellular location: nucleus

TKV s64 sa46 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

HOMODIMER ID 15STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

TRANSPORT_LEFT__proDPP-RIGHT__proDPP-_re5
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 168
left: proDPP
interaction type: TRANSPORT
right: proDPP

TRUNCATION_LEFT__proDPP-RIGHT__DPP-_?-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 163
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 162
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 161
left: proDPP
interaction type: TRUNCATION
right: ?
right: DPP

TKV
type: Protein
entity reference: TKV
feature: TKV s9 sa2 rs1

? s27 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

TKV s58 sa41 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

DISSOCIATION_LEFT__PUT_DPP_phosphoTKV_phosphoMAD-RIGHT__phosphoTKV__DPP_PUT-_MAD-_re21
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 226
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 227
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 225
left: PUT/DPP phosphoTKV phosphoMAD
interaction type: DISSOCIATION
right: phosphoTKV/ DPP/PUT
right: MAD

PUT
type: Protein
entity reference: PUT

PARTICIPANT STOICHIOMETRY re19 164
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re19 165
type: Stoichiometry
physical entity: PUT/DPP phosphoTKV MAD
stoichiometric coefficient: 1.0

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

PUT
type: Protein
entity reference: PUT
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

HOMODIMER ID 49STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

DPP s22 sa20 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

TKV
type: Protein
entity reference: TKV
feature: TKV s130 sa96 rs1

MAD s62 sa44 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re19 167
type: Stoichiometry
physical entity: PUT/DPP phosphoTKV phosphoMAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 166
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 2.0

PUT s12 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PUT s76 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

MAD s99 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re5 168
type: Stoichiometry
physical entity: proDPP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 169
type: Stoichiometry
physical entity: proDPP
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__MED__phosphoMAD-_SHN-RIGHT__SHN_MED__phosphoMAD-_re26
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 218
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 220
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 219
left: MED/ phosphoMAD
left: SHN
interaction type: HETERODIMER_ASSOCIATION
right: SHN/MED/ phosphoMAD

By Homology
type: RelationshipTypeVocabulary

DPP
type: ProteinReference
xref: P06285
standard name: decapentaplegic
comment: ENTITY_REFERENCE_PROTEIN_TYPE=TRUNCATED
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.TRUNCATED.DPP
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein decapentaplegic

LACK
type: Protein
entity reference: LACK
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PUT/DPP phosphoTKV MAD
type: Complex
component stoichiometry: MAD s67 sa48 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 14STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 48STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 38STOICHIOMETRY ID COMPLEX
component: PUT
component: MAD
component: TKV
component: DPP
feature: COMPLEX BINDING FEATURE s66 csa9 143
feature: COMPLEX BINDING FEATURE s66 csa9 147
feature: COMPLEX BINDING FEATURE s66 csa9 145
feature: COMPLEX BINDING FEATURE s66 csa9 141
cellular location: cytosol

DPP
type: Protein
entity reference: DPP

IDA
type: EvidenceCodeVocabulary

STATE_TRANSITION_LEFT__MAD-RIGHT__sa105_degraded-_re43
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 195
left: MAD
interaction type: STATE_TRANSITION
right: sa105_degraded

eco ECO:0000304 43
type: UnificationXref
id: ECO:0000304
db: eco

HOMODIMER ID 65STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

Mothers against decapentaplegic homolog
type: ProteinReference
evidence: Evidence 62
xref: uniprot Q5U110 61
xref: PTHR13703:SF54
organism: Drosophila melanogaster

PUT
type: Protein
entity reference: PUT

uniprot P42003 22
type: UnificationXref
id: P42003
db: uniprot

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s108 sa76 70
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

DPP
type: Protein
entity reference: DPP

TKV s9 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

PUT s124 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

MAD
type: Protein
entity reference: MAD
feature: MAD s113 sa78 rs2
feature: MAD s113 sa78 rs1

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

SHN
type: Protein
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: PTHR42884:SF3
xref: uniprot P26016 58
organism: Drosophila melanogaster

PANTHER Pathway P06213 1
type: UnificationXref
id: P06213
db: PANTHER Pathway

TSG
type: Protein
entity reference: TSG
feature: COMPLEX PARTICIPANT BINDING FEATURE s51 sa38 118
comment: SPECIES_TYPE=PROTEIN

TSG
type: ProteinReference
xref: P06287
standard name: twisted gastrulation
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.TSG
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein twisted gastrulation

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 43

DISSOCIATION_LEFT__SOG_TSG_DPP_dimer-RIGHT__SOG-_TSG-_DPP-_re12
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 199
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 198
left: SOG/TSG DPP dimer
interaction type: DISSOCIATION
right: TSG
right: DPP
right: SOG

MAD
type: ProteinReference
xref: P06288
standard name: mothers against dpp
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.MAD
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Protein mothers against dpp

PUT
type: Protein
entity reference: PUT

FUR1
type: Protein
entity reference: FUR1
cellular location: Golgi apparatus
comment: SPECIES_TYPE=PROTEIN

DAD
type: ProteinReference
xref: P06291
standard name: Daughters against dpp
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.DAD
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Mothers against decapentaplegic homolog

PARTICIPANT STOICHIOMETRY re2 184
type: Stoichiometry
physical entity: TKV/DPP/ PUT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 182
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re2 183
type: Stoichiometry
physical entity: DPP dimer/ TKV
stoichiometric coefficient: 1.0

DPP
type: Protein
entity reference: DPP

HOMODIMER ID 36STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

TKV
type: ProteinReference
xref: P06286
standard name: thickveins
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.RECEPTOR.TKV
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Receptor protein serine/threonine kinase

TSG s51 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TSG
stoichiometric coefficient: 1.0

HOMODIMER ID 54STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

SOG
type: Protein
entity reference: SOG
comment: SPECIES_TYPE=PROTEIN

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

LACK s141 sa102 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: LACK
stoichiometric coefficient: 1.0

P06291
type: UnificationXref
id: P06291
db: PANTHER Pathway Component

P06293
type: UnificationXref
id: P06293
db: PANTHER Pathway Component

DPP
type: Protein
entity reference: DPP

PARTICIPANT STOICHIOMETRY re11 203
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re11 204
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re41
controller: LACK

HOMODIMER ID 14STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

P06290
type: UnificationXref
id: P06290
db: PANTHER Pathway Component

TKV/DPP/ PUT
type: Complex
component stoichiometry: HOMODIMER ID 34STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 47STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 13STOICHIOMETRY ID COMPLEX
component: DPP
component: PUT
component: TKV
feature: COMPLEX BINDING FEATURE s1 csa1 123
feature: COMPLEX BINDING FEATURE s1 csa1 121
feature: COMPLEX BINDING FEATURE s1 csa1 119
cellular location: cytosol

MED
type: Protein
entity reference: MED
feature: COMPLEX PARTICIPANT BINDING FEATURE s100 sa68 76
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re43 195
type: Stoichiometry
physical entity: sa105_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re43 194
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 227
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 226
type: Stoichiometry
physical entity: phosphoTKV/ DPP/PUT
stoichiometric coefficient: 1.0

proDPP
type: Complex
component stoichiometry: HOMODIMER ID 35STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 64STOICHIOMETRY ID COMPLEX
component: ?
component: DPP
feature: COMPLEX BINDING FEATURE s21 csa5 133
feature: COMPLEX BINDING FEATURE s21 csa5 135
cellular location: unknown c3

PARTICIPANT STOICHIOMETRY re21 225
type: Stoichiometry
physical entity: PUT/DPP phosphoTKV phosphoMAD
stoichiometric coefficient: 1.0

ncbitaxon 7227 7
type: UnificationXref
id: 7227
db: ncbitaxon

HOMODIMER ID 55STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 2.0

DPP_signaling_pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__phosphoTKV__DPP_PUT-_DAD-RIGHT__phosphoTKV__DPP_PUT_DAD-_re38
pathway component: HETERODIMER_ASSOCIATION_LEFT__MED__phosphoMAD-_NEJ-RIGHT__NEJ_MED__phosphoMAD-_re28
pathway component: DISSOCIATION_LEFT__phosphoMAD_LACK-RIGHT__LACK-_MAD-_re42
pathway component: TRANSPORT_LEFT__DPP-RIGHT__DPP-_re11
pathway component: TRANSPORT_LEFT__MED__phosphoMAD-RIGHT__MED__phosphoMAD-_re24
pathway component: HETERODIMER_ASSOCIATION_LEFT__SOG-_TSG-_DPP-RIGHT__SOG_TSG_DPP_dimer-_re10
pathway component: STATE_TRANSITION_LEFT__TKV-RIGHT__TKV-_re13
pathway component: STATE_TRANSITION_LEFT__MAD-RIGHT__MAD-_re22
pathway component: TRUNCATION_LEFT__DPP_full_length-RIGHT__?-_DPP-_re4
pathway component: TRUNCATION_LEFT__proDPP-RIGHT__DPP-_?-_re6
pathway component: STATE_TRANSITION_LEFT__ATP-_TKV_DPP__PUT-RIGHT__phosphoTKV__DPP_PUT-_ADP-_re3
pathway component: TRANSPORT_LEFT__proDPP-RIGHT__proDPP-_re5
pathway component: TRANSPORT_LEFT__MAD-RIGHT__MAD-_re37
pathway component: STATE_TRANSITION_LEFT__PUT-RIGHT__PUT-_re15
pathway component: STATE_TRANSITION_LEFT__ATP-_PUT_DPP_phosphoTKV_MAD-RIGHT__ADP-_PUT_DPP_phosphoTKV_phosphoMAD-_re19
pathway component: HETERODIMER_ASSOCIATION_LEFT__DPP-_TKV-RIGHT__DPP_dimer__TKV-_re1
pathway component: TRANSPORT_LEFT__TKV-RIGHT__TKV-_re14
pathway component: HETERODIMER_ASSOCIATION_LEFT__phosphoTKV__DPP_PUT-_MAD-RIGHT__PUT_DPP_phosphoTKV_MAD-_re17
pathway component: TRANSPORT_LEFT__MED-RIGHT__MED-_re33
pathway component: STATE_TRANSITION_LEFT__MAD-_MED-RIGHT__MAD-_MED__phosphoMAD-_re40
pathway component: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MED-_MAD-_re32
pathway component: STATE_TRANSITION_LEFT__MAD-RIGHT__sa105_degraded-_re43
pathway component: STATE_TRANSITION_LEFT__phosphoMAD_LACK-RIGHT__phosphoMAD_LACK-_re41
pathway component: TRANSPORT_LEFT__MAD-RIGHT__MAD-_re36
pathway component: HETERODIMER_ASSOCIATION_LEFT__MED__phosphoMAD-_SHN-RIGHT__SHN_MED__phosphoMAD-_re26
pathway component: HETERODIMER_ASSOCIATION_LEFT__PUT-_DPP_dimer__TKV-RIGHT__TKV_DPP__PUT-_re2
pathway component: DISSOCIATION_LEFT__PUT_DPP_phosphoTKV_phosphoMAD-RIGHT__phosphoTKV__DPP_PUT-_MAD-_re21
pathway component: TRANSPORT_LEFT__PUT-RIGHT__PUT-_re16
pathway component: HETERODIMER_ASSOCIATION_LEFT__MAD-_LACK-RIGHT__phosphoMAD_LACK-_re39
pathway component: DISSOCIATION_LEFT__SOG_TSG_DPP_dimer-RIGHT__SOG-_TSG-_DPP-_re12
xref: PANTHER Pathway P06213 1
comment: MODEL_NOTES=

DPP s49 sa36 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

Nejire, isoform C
type: ProteinReference
xref: PTHR13808:SF1
xref: uniprot M9MS40 29
organism: Drosophila melanogaster

STATE_TRANSITION
type: InteractionVocabulary

GM14286p
type: ProteinReference
xref: PTHR13832:SF571
xref: uniprot Q9W3Q1 23
organism: Drosophila melanogaster

DPP s131 sa97 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

SHN/MED/ phosphoMAD
type: Complex
component stoichiometry: SHN s109 sa77 STOICHIOMETRY ID COMPLEX
component stoichiometry: HOMODIMER ID 56STOICHIOMETRY ID COMPLEX
component stoichiometry: MED s108 sa76 STOICHIOMETRY ID COMPLEX
component: MAD
component: MED
component: SHN
feature: COMPLEX BINDING FEATURE s110 csa14 71
feature: COMPLEX BINDING FEATURE s110 csa14 69
feature: COMPLEX BINDING FEATURE s110 csa14 67
cellular location: nucleus

TRANSPORT
type: InteractionVocabulary

TKV s13 sa5 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=4.31

MED s114 sa79 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

TRUNCATION
type: InteractionVocabulary

HETERODIMER_ASSOCIATION_LEFT__MAD-_LACK-RIGHT__phosphoMAD_LACK-_re39
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 229
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 230
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 228
left: LACK
left: MAD
interaction type: HETERODIMER_ASSOCIATION
right: phosphoMAD LACK

TSG
type: Protein
entity reference: TSG
comment: SPECIES_TYPE=PROTEIN

phosphoMAD LACK
type: Complex
component stoichiometry: MAD s140 sa101 STOICHIOMETRY ID COMPLEX
component stoichiometry: LACK s141 sa102 STOICHIOMETRY ID COMPLEX
component: MAD
component: LACK
feature: COMPLEX BINDING FEATURE s136 csa17 91
feature: COMPLEX BINDING FEATURE s136 csa17 89
cellular location: cytosol

TRANSPORT_LEFT__TKV-RIGHT__TKV-_re14
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 190
left: TKV
interaction type: TRANSPORT
right: TKV

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

uniprot Q9W3Q1 23
type: UnificationXref
id: Q9W3Q1
db: uniprot

MAD s140 sa101 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

TKV s125 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

HOMODIMER ID 48STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

uniprot P07713 25
type: UnificationXref
id: P07713
db: uniprot

?
type: Protein

PARTICIPANT STOICHIOMETRY re4 170
type: Stoichiometry
physical entity: DPP full length
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re4 171
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY re4 172
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

E3 ubiquitin-protein ligase Smurf1
type: ProteinReference
evidence: Evidence 19
xref: PTHR11254:SF395
xref: uniprot Q9V853 18
organism: Drosophila melanogaster

MAD s99 sa66 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

FUR1
type: ProteinReference
xref: P06290
standard name: furin 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=DPP_signaling_pathway.PROTEIN.GENERIC.FUR1
comment: ENTITY_REFERENCE_NOTES=
member entity reference: Furin-like protease 1, isoforms 1/1-X/2

PARTICIPANT STOICHIOMETRY re32 160
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__PUT-_DPP_dimer__TKV-RIGHT__TKV_DPP__PUT-_re2
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 183
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 184
left: DPP dimer/ TKV
left: PUT
interaction type: HETERODIMER_ASSOCIATION
right: TKV/DPP/ PUT

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

phosphoMAD LACK
type: Complex
component stoichiometry: LACK s143 sa104 STOICHIOMETRY ID COMPLEX
component stoichiometry: MAD s144 sa103 STOICHIOMETRY ID COMPLEX
component: MAD
component: LACK
feature: COMPLEX BINDING FEATURE s142 csa18 93
feature: COMPLEX BINDING FEATURE s142 csa18 95
cellular location: cytosol

MAD s79 sa58 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 30

PUT s68 sa45 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

Target genes
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

PPM1A
type: Protein
entity reference: PPM1A
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

MAD s145 sa105 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

MAD s92 sa65 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: MAD
stoichiometric coefficient: 3.0

PARTICIPANT STOICHIOMETRY re32 159
type: Stoichiometry
physical entity: MED
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re32 158
type: Stoichiometry
physical entity: MED/ phosphoMAD
stoichiometric coefficient: 1.0

HOMODIMER ID 17STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PUT
stoichiometric coefficient: 2.0

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

MAD s99 sa66 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

STATE_TRANSITION_LEFT__MAD-RIGHT__MAD-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 224
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 223
left: MAD
interaction type: STATE_TRANSITION
right: MAD

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__MED__phosphoMAD-RIGHT__MED-_MAD-_re32
controller: PDP

MAD
type: Protein
entity reference: MAD
feature: MAD s107 sa75 rs1
feature: MAD s107 sa75 rs2

? s35 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 2.0

HOMODIMER ID 46STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: TKV
stoichiometric coefficient: 2.0

MAD s79 sa58 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=4.24
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

HOMODIMER ID 40STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DPP
stoichiometric coefficient: 2.0

Alphabet, isoform E
type: ProteinReference
evidence: Evidence 60
xref: PTHR47992:SF25
xref: uniprot Q961C5 59
organism: Drosophila melanogaster

MAD s145 sa105 rs2
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793