Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot P04046 504
organism: Saccharomyces cerevisiae

uniprot Q9U1E1 78
type: UnificationXref
id: Q9U1E1
db: uniprot

uniprot Q10S93 311
type: UnificationXref
id: Q10S93
db: uniprot

uniprot F7H3S6 283
type: UnificationXref
id: F7H3S6
db: uniprot

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q8ZT92 374
organism: Pyrobaculum aerophilum

ADP reductase
type: ProteinReference
xref: P02902
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.ADP reductase
comment: ENTITY_REFERENCE_NOTES=Long Name: ADP reductase Synonym: Synonym not specified Accession: P02902
member entity reference: Ribonucleoside-diphosphate reductase
member entity reference: Vitamin B12-dependent ribonucleotide reductase
member entity reference: Ribonucleotide reductase small subunit
member entity reference: Ribonucleoside-diphosphate reductase subunit M2
member entity reference: Ribonucleoside-diphosphate reductase subunit M2 B
member entity reference: Ribonucleotide reductase regulatory TP53 inducible subunit M2B
member entity reference: Ribonucleoside-diphosphate reductase 1 subunit alpha
member entity reference: Ribonucleoside-diphosphate reductase small chain 2
member entity reference: Ribonucleoside-diphosphate reductase large subunit
member entity reference: AGAP006818-PA
member entity reference: Ribonucleoside-diphosphate reductase (Fragment)
member entity reference: Ribonucleoside-diphosphate reductase subunit beta nrdF1
member entity reference: SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta
member entity reference: Ribonucleoside-diphosphate reductase subunit beta
member entity reference: Ribonucleoside-diphosphate reductase small chain
member entity reference: Ribonucleotide reductase regulatory subunit M2
member entity reference: Ribonucleoside-diphosphate reductase large chain
member entity reference: Vitamin B12-dependent ribonucleoside-diphosphate reductase
member entity reference: Uncharacterized protein
member entity reference: Ribonucleoside-diphosphate reductase large chain 2
member entity reference: Ribonucleoside reductase small chain
member entity reference: Ribonucleoside-diphosphate reductase subunit alpha
member entity reference: Ribonucleotide reductase
member entity reference: Ribonucleoside-diphosphate reductase 2 subunit alpha
member entity reference: Ribonucleoside-diphosphate reductase 1 subunit beta
member entity reference: Ribonucleoside-diphosphate reductase NrdEB subunit alpha
member entity reference: Ribonucleotide reductase M2 polypeptide
member entity reference: Ribonucleoside-diphosphate reductase large chain 1
member entity reference: Ribonucleoside-diphosphate reductase 2 subunit beta
member entity reference: Ribonucleoside-diphosphate reductase subunit beta nrdF2
member entity reference: Ribonucleoside-diphosphate reductase small chain 1

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P36010 41
organism: Saccharomyces cerevisiae

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: uniprot P48592 425
organism: Drosophila melanogaster

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot P48591 424
organism: Drosophila melanogaster

Adenylate kinase 3
type: ProteinReference
xref: uniprot Q08479 307
organism: Oryza sativa

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q9P772 380
organism: Schizosaccharomyces pombe

Adenylate kinase 8
type: ProteinReference
xref: uniprot Q32M07 313
organism: Mus musculus

uniprot Q8THC7 372
type: UnificationXref
id: Q8THC7
db: uniprot

uniprot Q8I2U5 255
type: UnificationXref
id: Q8I2U5
db: uniprot

uniprot Q51342 512
type: UnificationXref
id: Q51342
db: uniprot

uniprot Q9HSH4 377
type: UnificationXref
id: Q9HSH4
db: uniprot

Nucleoside diphosphate kinase 6
type: ProteinReference
xref: uniprot O88425 144
organism: Mus musculus

adenylo-succinate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 243230 128
type: UnificationXref
id: 243230
db: ncbitaxon

uniprot Q7SXL4 69
type: UnificationXref
id: Q7SXL4
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9L0I7 260
organism: Streptomyces coelicolor

uniprot P07170 292
type: UnificationXref
id: P07170
db: uniprot

Guanylate kinase
type: ProteinReference
xref: uniprot Q9HTM2 489
organism: Pseudomonas aeruginosa

uniprot Q8IL94 454
type: UnificationXref
id: Q8IL94
db: uniprot

uniprot Q6NMK6 319
type: UnificationXref
id: Q6NMK6
db: uniprot

uniprot Q3THK7 364
type: UnificationXref
id: Q3THK7
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot A0A2I3TVQ6 156
organism: Pan troglodytes

uniprot Q96MA6 331
type: UnificationXref
id: Q96MA6
db: uniprot

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q06203 509
organism: Homo sapiens

uniprot Q382Q0 441
type: UnificationXref
id: Q382Q0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BI58 390
organism: Bos taurus

Nucleoside diphosphate kinase 7
type: ProteinReference
xref: uniprot Q9QXL8 151
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 33

ncbitaxon 367110 81
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot Q8ZT92 374
type: UnificationXref
id: Q8ZT92
db: uniprot

Nucleoside diphosphate kinase 7
type: ProteinReference
xref: uniprot Q9QXL7 150
organism: Rattus norvegicus

GMP synthase [glutamine-hydrolyzing] subunit B
type: ProteinReference
xref: uniprot Q58531 366
organism: Methanocaldococcus jannaschii

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot O66601 356
organism: Aquifex aeolicus

uniprot A0A2R8RXT8 267
type: UnificationXref
id: A0A2R8RXT8
db: uniprot

uniprot O67528 25
type: UnificationXref
id: O67528
db: uniprot

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
type: ProteinReference
xref: uniprot F1P797 190
organism: Canis lupus familiaris

uniprot P43414 301
type: UnificationXref
id: P43414
db: uniprot

PARTICIPANT STOICHIOMETRY r25 672
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Guanylate kinase
type: ProteinReference
xref: uniprot Q64520 485
organism: Mus musculus

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot O66856 162
organism: Aquifex aeolicus

PARTICIPANT STOICHIOMETRY r9 601
type: Stoichiometry
physical entity: THF
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot A8XAI1 387
organism: Caenorhabditis briggsae

PARTICIPANT STOICHIOMETRY r9 600
type: Stoichiometry
physical entity: phosphoribosyl-formamido-carboxamide
stoichiometric coefficient: 1.0

uniprot H2Q4V0 539
type: UnificationXref
id: H2Q4V0
db: uniprot

Adenylosuccinate synthetase isozyme 2
type: ProteinReference
xref: uniprot F7BUU3 93
xref: PTHR11846:SF13
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r25 670
type: Stoichiometry
physical entity: dATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 671
type: Stoichiometry
physical entity: Red FlR
stoichiometric coefficient: 1.0

uniprot A0A2I3TM38 220
type: UnificationXref
id: A0A2I3TM38
db: uniprot

Adenylate kinase 2, mitochondrial
type: ProteinReference
xref: uniprot A0A1D5QK39 264
organism: Macaca mulatta

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot A0A2J8PA11 134
organism: Pan troglodytes

ncbitaxon 284591 566
type: UnificationXref
id: 284591
db: ncbitaxon

uniprot E2RND9 279
type: UnificationXref
id: E2RND9
db: uniprot

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q9L0H2 379
organism: Streptomyces coelicolor

uniprot F6VXT4 228
type: UnificationXref
id: F6VXT4
db: uniprot

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P49057 361
organism: Synechocystis

uniprot F1P9U2 353
type: UnificationXref
id: F1P9U2
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_dADP-RIGHT__ADP-_dATP-_r24
controller: dADP kinase

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 81

uniprot P48592 425
type: UnificationXref
id: P48592
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__5_phosphoribosyl_N_formyl_glycineamide-_ATP-RIGHT__PO4-_ADP-_5_phosphoribosyl_5_aminoimidazole-_r4
controller: Phosphoribosylformylglycinamide synthase

uniprot F6TXD9 91
type: UnificationXref
id: F6TXD9
db: uniprot

uniprot P72648 480
type: UnificationXref
id: P72648
db: uniprot

uniprot P50620 427
type: UnificationXref
id: P50620
db: uniprot

GDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q57657 514
organism: Methanocaldococcus jannaschii

uniprot Q9HUV9 213
type: UnificationXref
id: Q9HUV9
db: uniprot

N5-carboxyaminoimidazole ribonucleotide mutase
type: ProteinReference
xref: uniprot Q8A4S9 532
organism: Bacteroides thetaiotaomicron

Adenylate kinase 4
type: ProteinReference
xref: uniprot Q08480 308
organism: Oryza sativa

uniprot Q9VTB3 494
type: UnificationXref
id: Q9VTB3
db: uniprot

Protein CBG03104
type: ProteinReference
xref: uniprot A8WSS5 271
organism: Caenorhabditis briggsae

STATE_TRANSITION_LEFT__NAD-_H2O-_IMP-RIGHT__NADH-_xanthosine_5_phosphate-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 629
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 630
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 633
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 631
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 632
left: H2O
left: IMP
left: NAD
interaction type: STATE_TRANSITION
right: NADH
right: xanthosine-5-phosphate

ncbitaxon 284812 45
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q27601 511
type: UnificationXref
id: Q27601
db: uniprot

Ribonucleotide reductase M2 polypeptide
type: ProteinReference
xref: uniprot D4A7M6 388
organism: Rattus norvegicus

ncbitaxon 9544 11
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot Q08479 307
type: UnificationXref
id: Q08479
db: uniprot

PARTICIPANT STOICHIOMETRY r18 590
type: Stoichiometry
physical entity: Red FlR
stoichiometric coefficient: 1.0

AGAP006818-PA
type: ProteinReference
xref: uniprot Q7QIF4 453
organism: Anopheles gambiae

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q05911 169
organism: Saccharomyces cerevisiae

GMP synthase [glutamine-hydrolyzing] subunit A
type: ProteinReference
xref: uniprot Q58970 367
organism: Methanocaldococcus jannaschii

PARTICIPANT STOICHIOMETRY r3 656
type: Stoichiometry
physical entity: 5-phosphoribosyl N-formyl glycineamide
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__phosphoribosyl_formamido_carboxamide-RIGHT__H2O-_IMP-_r10
controller: IMP cyclohydrolase

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q9U1E1 78
organism: Leishmania major

PARTICIPANT STOICHIOMETRY r3 655
type: Stoichiometry
physical entity: 5-phosphoribosoyl glycineamide
stoichiometric coefficient: 1.0

uniprot P60546 479
type: UnificationXref
id: P60546
db: uniprot

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q9K496 468
organism: Streptomyces coelicolor

PARTICIPANT STOICHIOMETRY r20 580
type: Stoichiometry
physical entity: Aspartate
stoichiometric coefficient: 1.0

uniprot P32073 359
type: UnificationXref
id: P32073
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 16

ncbitaxon 7227 30
type: UnificationXref
id: 7227
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HA84 12
organism: Macaca mulatta

NME/NM23 family member 5
type: ProteinReference
xref: uniprot H2QRJ9 140
organism: Pan troglodytes

uniprot Q93576 76
type: UnificationXref
id: Q93576
db: uniprot

PARTICIPANT STOICHIOMETRY r18 592
type: Stoichiometry
physical entity: Ox FlR
stoichiometric coefficient: 1.0

uniprot P21879 237
type: UnificationXref
id: P21879
db: uniprot

Adenylate kinase
type: ProteinReference
xref: uniprot Q8TRS3 327
organism: Methanosarcina acetivorans

PARTICIPANT STOICHIOMETRY r18 591
type: Stoichiometry
physical entity: dGTP
stoichiometric coefficient: 1.0

uniprot A0A1D5Q2L2 385
type: UnificationXref
id: A0A1D5Q2L2
db: uniprot

PARTICIPANT STOICHIOMETRY r20 581
type: Stoichiometry
physical entity: IMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 582
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 583
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 584
type: Stoichiometry
physical entity: adenylo-succinate
stoichiometric coefficient: 1.0

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: uniprot G3V918 546
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r25 669
type: Stoichiometry
physical entity: Ox FlR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r20 579
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot H2R178 232
type: UnificationXref
id: H2R178
db: uniprot

Adenylosuccinate synthetase 1
type: ProteinReference
xref: uniprot Q8TPJ2 121
xref: PTHR11846:SF0
organism: Methanosarcina acetivorans

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P04079 357
organism: Escherichia coli

PARTICIPANT STOICHIOMETRY r18 589
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot O60105 161
type: UnificationXref
id: O60105
db: uniprot

uniprot Q9L0Z8 261
type: UnificationXref
id: Q9L0Z8
db: uniprot

uniprot Q9HE76 333
type: UnificationXref
id: Q9HE76
db: uniprot

Adenylosuccinate synthetase isozyme 2
type: ProteinReference
xref: PTHR11846:SF13
xref: uniprot P30520 99
organism: Homo sapiens

ncbitaxon 83332 53
type: UnificationXref
id: 83332
db: ncbitaxon

Inosine-5'-monophosphate dehydrogenase 1
type: ProteinReference
xref: uniprot F6S675 226
organism: Xenopus tropicalis

Putative adenylate kinase
type: ProteinReference
xref: uniprot Q9U1D3 338
organism: Leishmania major

uniprot Q8IM38 455
type: UnificationXref
id: Q8IM38
db: uniprot

uniprot O66949 547
type: UnificationXref
id: O66949
db: uniprot

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot P50621 428
organism: Bacillus subtilis

Guanylate kinase
type: ProteinReference
xref: P02904
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.Guanylate kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: Guanylate kinase Synonym: Synonym not specified Accession: P02904
member entity reference: Guanylate kinase
member entity reference: GUanylate Kinase
member entity reference: Guanylate kinase 1
member entity reference: Guanylate kinase 2
member entity reference: GH06691p
member entity reference: Guanylate kinase 3, chloroplastic
member entity reference: AGAP011105-PA

Ribonucleoside-diphosphate reductase subunit alpha
type: ProteinReference
xref: uniprot P50620 427
organism: Bacillus subtilis

eco ECO:0000250 84
type: UnificationXref
id: ECO:0000250
db: eco

uniprot F7CDE0 10
type: UnificationXref
id: F7CDE0
db: uniprot

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: uniprot P11157 413
organism: Mus musculus

Down syndrome cell adhesion molecule-like protein 1 homolog
type: ProteinReference
xref: uniprot Q4VA61 540
organism: Mus musculus

ncbitaxon 100226 47
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot A0A1D5QBQ1 350
type: UnificationXref
id: A0A1D5QBQ1
db: uniprot

ncbitaxon 1111708 51
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot Q7Q1H5 561
type: UnificationXref
id: Q7Q1H5
db: uniprot

glutamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Adenylosuccinate synthetase isozyme 2
type: ProteinReference
xref: uniprot D4AEP0 88
xref: PTHR11846:SF13
organism: Rattus norvegicus

uniprot Q382Q3 444
type: UnificationXref
id: Q382Q3
db: uniprot

Phosphoribosylglycinamide formyltransferase
type: ProteinReference
xref: uniprot P08179 549
organism: Escherichia coli

uniprot Q9HPG8 463
type: UnificationXref
id: Q9HPG8
db: uniprot

Phosphoribosylaminoimidazolecarboxamide formyltransferase
type: ProteinReference
xref: uniprot Q8TIX7 209
organism: Methanosarcina acetivorans

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P74494 50
organism: Synechocystis

Ribonucleoside-diphosphate reductase subunit M2 B
type: ProteinReference
xref: uniprot Q7LG56 452
organism: Homo sapiens

STATE_TRANSITION_LEFT__5_phosphoribosoyl_glycineamide-RIGHT__5_phosphoribosyl_N_formyl_glycineamide-_r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 645
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 646
left: 5-phosphoribosoyl glycineamide
interaction type: STATE_TRANSITION
right: 5-phosphoribosyl N-formyl glycineamide

Ribonucleoside-diphosphate reductase small chain A
type: ProteinReference
xref: uniprot P50651 429
organism: Arabidopsis thaliana

ncbitaxon 5664 79
type: UnificationXref
id: 5664
db: ncbitaxon

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q8RY94 176
organism: Arabidopsis thaliana

uniprot P50096 243
type: UnificationXref
id: P50096
db: uniprot

Adenylate kinase
type: ProteinReference
xref: uniprot Q9RSK7 337
organism: Deinococcus radiodurans

GTP reductase
type: Protein
entity reference: GTP reductase
comment: SPECIES_TYPE=PROTEIN

uniprot P26364 295
type: UnificationXref
id: P26364
db: uniprot

uniprot P12048 196
type: UnificationXref
id: P12048
db: uniprot

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot Q9HPG8 463
organism: Halobacterium salinarum

uniprot Q9HMU3 461
type: UnificationXref
id: Q9HMU3
db: uniprot

Adenosuccinate lyase
type: Protein
entity reference: Adenosuccinate lyase
comment: SPECIES_TYPE=PROTEIN

uniprot P15454 477
type: UnificationXref
id: P15454
db: uniprot

AGAP010139-PA
type: ProteinReference
xref: uniprot Q7Q0V2 369
organism: Anopheles gambiae

uniprot Q9X0X4 529
type: UnificationXref
id: Q9X0X4
db: uniprot

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot P79732 433
organism: Danio rerio

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q7AKK3 515
organism: Streptomyces coelicolor

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: uniprot P79733 434
organism: Danio rerio

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot H2QPI4 501
organism: Pan troglodytes

NME/NM23 family member 5
type: ProteinReference
xref: uniprot D3ZH90 135
organism: Rattus norvegicus

uniprot O69981 407
type: UnificationXref
id: O69981
db: uniprot

STATE_TRANSITION_LEFT__GTP-_Red_FlR-RIGHT__dGTP-_Ox_FlR-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 590
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 589
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 591
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 592
left: Red FlR
left: GTP
interaction type: STATE_TRANSITION
right: Ox FlR
right: dGTP

ncbitaxon 64091 49
type: UnificationXref
id: 64091
db: ncbitaxon

uniprot Q7Q1R6 320
type: UnificationXref
id: Q7Q1R6
db: uniprot

uniprot Q5JIE6 112
type: UnificationXref
id: Q5JIE6
db: uniprot

Guanylate kinase 1
type: ProteinReference
xref: uniprot P93757 482
organism: Arabidopsis thaliana

uniprot Q9VY27 153
type: UnificationXref
id: Q9VY27
db: uniprot

uniprot Q3SWY3 247
type: UnificationXref
id: Q3SWY3
db: uniprot

uniprot P08879 29
type: UnificationXref
id: P08879
db: uniprot

Adenylate kinase
type: Protein
entity reference: Adenylate kinase
comment: SPECIES_TYPE=PROTEIN

uniprot F1NAQ8 352
type: UnificationXref
id: F1NAQ8
db: uniprot

uniprot P50651 429
type: UnificationXref
id: P50651
db: uniprot

uniprot P49915 362
type: UnificationXref
id: P49915
db: uniprot

uniprot P54822 167
type: UnificationXref
id: P54822
db: uniprot

uniprot P29726 98
type: UnificationXref
id: P29726
db: uniprot

uniprot Q9X168 263
type: UnificationXref
id: Q9X168
db: uniprot

GTP:AMP phosphotransferase AK3, mitochondrial
type: ProteinReference
xref: uniprot P29411 298
organism: Rattus norvegicus

Adenylate kinase 2, mitochondrial
type: ProteinReference
xref: uniprot P29410 297
organism: Rattus norvegicus

uniprot B4YY02 273
type: UnificationXref
id: B4YY02
db: uniprot

uniprot Q4VA61 540
type: UnificationXref
id: Q4VA61
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot A0A1D5R3I3 219
organism: Macaca mulatta

Adenylate kinase 4, mitochondrial
type: ProteinReference
xref: uniprot P27144 296
organism: Homo sapiens

uniprot F7A4H4 399
type: UnificationXref
id: F7A4H4
db: uniprot

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot F7A4H4 399
organism: Monodelphis domestica

uniprot Q7PXI8 205
type: UnificationXref
id: Q7PXI8
db: uniprot

GTP:AMP phosphotransferase AK3, mitochondrial
type: ProteinReference
xref: uniprot F7H3S6 283
organism: Macaca mulatta

NME/NM23 family member 7
type: ProteinReference
xref: uniprot F1PMF2 138
organism: Canis lupus familiaris

uniprot P54113 201
type: UnificationXref
id: P54113
db: uniprot

uniprot P49057 361
type: UnificationXref
id: P49057
db: uniprot

Adenylate kinase
type: ProteinReference
xref: uniprot Q9HXV4 335
organism: Pseudomonas aeruginosa

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 39

uniprot P74240 431
type: UnificationXref
id: P74240
db: uniprot

Adenylate kinase isoenzyme 1
type: ProteinReference
xref: uniprot Q20140 312
organism: Caenorhabditis elegans

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8ZZJ6 521
type: UnificationXref
id: Q8ZZJ6
db: uniprot

uniprot P0AG16 505
type: UnificationXref
id: P0AG16
db: uniprot

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: uniprot Q20143 558
organism: Caenorhabditis elegans

uniprot Q8IQG9 324
type: UnificationXref
id: Q8IQG9
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 11

ncbitaxon 36329 118
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot Q8REV2 519
type: UnificationXref
id: Q8REV2
db: uniprot

GMP synthase
type: Protein
entity reference: GMP synthase
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r11 645
type: Stoichiometry
physical entity: 5-phosphoribosoyl glycineamide
stoichiometric coefficient: 1.0

uniprot Q8CIH9 518
type: UnificationXref
id: Q8CIH9
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot P54822 167
organism: Mus musculus

uniprot Q9HXV4 335
type: UnificationXref
id: Q9HXV4
db: uniprot

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q5JIE6 112
xref: PTHR11846:SF0
organism: Thermococcus kodakaraensis

PARTICIPANT STOICHIOMETRY r11 646
type: Stoichiometry
physical entity: 5-phosphoribosyl N-formyl glycineamide
stoichiometric coefficient: 1.0

uniprot H2R0X5 192
type: UnificationXref
id: H2R0X5
db: uniprot

uniprot Q9K3C2 467
type: UnificationXref
id: Q9K3C2
db: uniprot

uniprot Q9WTP7 343
type: UnificationXref
id: Q9WTP7
db: uniprot

Probable adenylate kinase 7, mitochondrial
type: ProteinReference
xref: uniprot Q8L7W7 325
organism: Arabidopsis thaliana

uniprot Q8TL49 520
type: UnificationXref
id: Q8TL49
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q21774 170
organism: Caenorhabditis elegans

dGDP kinase
type: ProteinReference
xref: P02889
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.dGDP kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: dGDP kinase Synonym: Synonym not specified Accession: P02889
member entity reference: Nucleoside diphosphate kinase
member entity reference: Nucleoside diphosphate kinase B
member entity reference: Nucleoside diphosphate kinase 3
member entity reference: Nucleoside diphosphate kinase, mitochondrial
member entity reference: Nucleoside diphosphate kinase 1
member entity reference: Nucleoside diphosphate kinase A
member entity reference: Nucleoside diphosphate kinase, cytosolic
member entity reference: Nucleoside diphosphate kinase II, chloroplastic
member entity reference: Uncharacterized protein
member entity reference: Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase III, chloroplastic/mitochondrial

uniprot P30566 166
type: UnificationXref
id: P30566
db: uniprot

Adenylate kinase
type: ProteinReference
xref: uniprot P69441 303
organism: Escherichia coli

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 75

Nucleoside diphosphate kinase B
type: ProteinReference
xref: uniprot Q01768 54
organism: Mus musculus

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P61136 48
organism: Halobacterium salinarum

uniprot Q9CWJ9 211
type: UnificationXref
id: Q9CWJ9
db: uniprot

uniprot P9WJH7 52
type: UnificationXref
id: P9WJH7
db: uniprot

uniprot Q9HMU4 462
type: UnificationXref
id: Q9HMU4
db: uniprot

Bifunctional purine biosynthesis protein PurH
type: ProteinReference
xref: uniprot Q9KY50 214
organism: Streptomyces coelicolor

uniprot P54819 302
type: UnificationXref
id: P54819
db: uniprot

GDP reductase
type: ProteinReference
xref: P02909
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: GDP reductase Synonym: Synonym not specified Accession: P02909
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.GDP reductase
member entity reference: Ribonucleoside-diphosphate reductase
member entity reference: Vitamin B12-dependent ribonucleotide reductase
member entity reference: Ribonucleotide reductase small subunit
member entity reference: Ribonucleoside-diphosphate reductase subunit M2
member entity reference: Ribonucleoside-diphosphate reductase subunit M2 B
member entity reference: Ribonucleotide reductase regulatory TP53 inducible subunit M2B
member entity reference: Ribonucleoside-diphosphate reductase 1 subunit alpha
member entity reference: Ribonucleoside-diphosphate reductase small chain 2
member entity reference: Ribonucleoside-diphosphate reductase large subunit
member entity reference: AGAP006818-PA
member entity reference: Ribonucleoside-diphosphate reductase (Fragment)
member entity reference: Ribonucleoside-diphosphate reductase subunit beta nrdF1
member entity reference: SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta
member entity reference: Ribonucleoside-diphosphate reductase subunit beta
member entity reference: Ribonucleoside-diphosphate reductase small chain
member entity reference: Ribonucleotide reductase regulatory subunit M2
member entity reference: Ribonucleoside-diphosphate reductase large chain
member entity reference: Vitamin B12-dependent ribonucleoside-diphosphate reductase
member entity reference: Uncharacterized protein
member entity reference: Ribonucleoside-diphosphate reductase large chain 2
member entity reference: Ribonucleoside reductase small chain
member entity reference: Ribonucleoside-diphosphate reductase subunit alpha
member entity reference: Ribonucleotide reductase
member entity reference: Ribonucleoside-diphosphate reductase 2 subunit alpha
member entity reference: Ribonucleoside-diphosphate reductase 1 subunit beta
member entity reference: Ribonucleoside-diphosphate reductase NrdEB subunit alpha
member entity reference: Ribonucleotide reductase M2 polypeptide
member entity reference: Ribonucleoside-diphosphate reductase large chain 1
member entity reference: Ribonucleoside-diphosphate reductase 2 subunit beta
member entity reference: Ribonucleoside-diphosphate reductase subunit beta nrdF2
member entity reference: Ribonucleoside-diphosphate reductase small chain 1

Ribonucleoside-diphosphate reductase subunit M2 B
type: ProteinReference
xref: uniprot A0A1D5Q2L2 385
organism: Macaca mulatta

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot P30566 166
organism: Homo sapiens

uniprot A0A1D5Q943 83
type: UnificationXref
id: A0A1D5Q943
db: uniprot

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot Q8TKT6 563
organism: Methanosarcina acetivorans

uniprot P22102 554
type: UnificationXref
id: P22102
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q7QBZ6 173
organism: Anopheles gambiae

uniprot Q8TFN0 72
type: UnificationXref
id: Q8TFN0
db: uniprot

Adenylosuccinate synthetase isozyme 1
type: ProteinReference
xref: PTHR11846:SF2
xref: uniprot F6TXD9 91
organism: Monodelphis domestica

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q5A0N3 447
organism: Candida albicans

STATE_TRANSITION_LEFT__5_phosphoribosyl_4__N_succino_carboxyamide__5_aminoimidazol-RIGHT__fumarate-_5_phosphoribosyl_5_amino_4_imidazole-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 607
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 608
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 606
left: 5-phosphoribosyl-4-(N-succino-carboxyamide)-5-aminoimidazol
interaction type: STATE_TRANSITION
right: fumarate
right: 5-phosphoribosyl-5-amino-4-imidazole

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 26

uniprot O84130 289
type: UnificationXref
id: O84130
db: uniprot

Probable lyase
type: ProteinReference
xref: uniprot Q9HY93 384
organism: Pseudomonas aeruginosa

uniprot Q8TIM8 120
type: UnificationXref
id: Q8TIM8
db: uniprot

uniprot Q8VYL1 329
type: UnificationXref
id: Q8VYL1
db: uniprot

Amidophosphoribosyltransferase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9SI61 526
organism: Arabidopsis thaliana

uniprot P50094 241
type: UnificationXref
id: P50094
db: uniprot

N5-carboxyaminoimidazole ribonucleotide mutase
type: ProteinReference
xref: P02911
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.N5-carboxyaminoimidazole_br_ribonucleotide mutase
comment: ENTITY_REFERENCE_NOTES=Long Name: N5-carboxyaminoimidazole ribonucleotide mutase Synonym: Synonym not specified Accession: P02911
member entity reference: Phosphoribosylaminoimidazole carboxylase
member entity reference: N5-carboxyaminoimidazole ribonucleotide mutase

uniprot Q94JM2 488
type: UnificationXref
id: Q94JM2
db: uniprot

uniprot P12044 531
type: UnificationXref
id: P12044
db: uniprot

uniprot O66490 288
type: UnificationXref
id: O66490
db: uniprot

uniprot F7DTY4 231
type: UnificationXref
id: F7DTY4
db: uniprot

Guanylate kinase
type: ProteinReference
xref: uniprot Q9KXS0 490
organism: Streptomyces coelicolor

Uncharacterized oxidoreductase Rv1843c
type: ProteinReference
xref: uniprot P9WKI3 244
organism: Mycobacterium tuberculosis

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8TL49 520
organism: Methanosarcina acetivorans

uniprot H2QY34 285
type: UnificationXref
id: H2QY34
db: uniprot

GTP:AMP phosphotransferase AK3, mitochondrial
type: ProteinReference
xref: uniprot E2RND9 279
organism: Canis lupus familiaris

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot Q03604 439
organism: Caenorhabditis elegans

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 123

uniprot P36010 41
type: UnificationXref
id: P36010
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot P9WKI7 245
organism: Mycobacterium tuberculosis

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot F1Q9U6 90
organism: Danio rerio

dGDP kinase
type: Protein
entity reference: dGDP kinase
comment: SPECIES_TYPE=PROTEIN

uniprot O31875 404
type: UnificationXref
id: O31875
db: uniprot

GDP kinase
type: Protein
entity reference: GDP kinase
comment: SPECIES_TYPE=PROTEIN

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot Q9RKL4 570
organism: Streptomyces coelicolor

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 47

uniprot F1P3I8 499
type: UnificationXref
id: F1P3I8
db: uniprot

PARTICIPANT STOICHIOMETRY r4 650
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot H2Q2Y0 402
organism: Pan troglodytes

GDP kinase
type: ProteinReference
xref: P02891
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.GDP kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: GDP kinase Synonym: Synonym not specified Accession: P02891
member entity reference: NME/NM23 family member 7
member entity reference: Nucleoside diphosphate kinase
member entity reference: Nucleoside diphosphate kinase homolog 5
member entity reference: Nucleoside diphosphate kinase B
member entity reference: Nucleoside diphosphate kinase 6
member entity reference: Nucleoside diphosphate kinase 7
member entity reference: Uncharacterized protein
member entity reference: NME/NM23 family member 5
member entity reference: Nucleoside diphosphate kinase A
member entity reference: Nucleoside diphosphate kinase, cytosolic
member entity reference: Nucleoside diphosphate kinase II, chloroplastic
member entity reference: Nucleoside diphosphate kinase 3
member entity reference: Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase, mitochondrial
member entity reference: Nucleoside diphosphate kinase 1
member entity reference: Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial

Adenylate kinase
type: ProteinReference
xref: uniprot P9WKF5 306
organism: Mycobacterium tuberculosis

uniprot D3ZW08 158
type: UnificationXref
id: D3ZW08
db: uniprot

Adenylate kinase 1, isoform B
type: ProteinReference
xref: uniprot Q8IQG9 324
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__N5_carboxyamino_imidazol_ribonucleotide-RIGHT__phosphoribosyl_carboxy_aminoimidazole-_r6
controller: N5-carboxyaminoimidazole ribonucleotide synthase

uniprot O34328 475
type: UnificationXref
id: O34328
db: uniprot

uniprot P11157 413
type: UnificationXref
id: P11157
db: uniprot

PARTICIPANT STOICHIOMETRY r19 585
type: Stoichiometry
physical entity: dGDP
stoichiometric coefficient: 1.0

Adenylosuccinate synthetase 2
type: ProteinReference
xref: uniprot Q8TIM8 120
xref: PTHR11846:SF0
organism: Methanosarcina acetivorans

PARTICIPANT STOICHIOMETRY r4 651
type: Stoichiometry
physical entity: 5-phosphoribosyl-5-aminoimidazole
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 586
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

dADP kinase
type: ProteinReference
xref: P02907
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: dADP kinase Synonym: Synonym not specified Accession: P02907
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.dADP kinase
member entity reference: NME/NM23 family member 7
member entity reference: Nucleoside diphosphate kinase
member entity reference: Nucleoside diphosphate kinase homolog 5
member entity reference: Nucleoside diphosphate kinase B
member entity reference: Nucleoside diphosphate kinase 6
member entity reference: Nucleoside diphosphate kinase 7
member entity reference: Uncharacterized protein
member entity reference: NME/NM23 family member 5
member entity reference: Down syndrome cell adhesion molecule-like protein 1
member entity reference: Nucleoside diphosphate kinase A
member entity reference: Nucleoside diphosphate kinase, cytosolic
member entity reference: Nucleoside diphosphate kinase II, chloroplastic
member entity reference: Nucleoside diphosphate kinase 3
member entity reference: Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase, mitochondrial
member entity reference: Nucleoside diphosphate kinase 1
member entity reference: DS cell adhesion molecule-like 1
member entity reference: Down syndrome cell adhesion molecule-like protein 1 homolog
member entity reference: DS cell adhesion molecule like 1
member entity reference: Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial

Inosine-5'-monophosphate dehydrogenase 2
type: ProteinReference
xref: uniprot P12268 236
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r19 587
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot P69924 430
type: UnificationXref
id: P69924
db: uniprot

PARTICIPANT STOICHIOMETRY r19 588
type: Stoichiometry
physical entity: dGTP
stoichiometric coefficient: 1.0

PTHR11846:SF2
type: RelationshipXref
id: PTHR11846:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q9QXL8 151
type: UnificationXref
id: Q9QXL8
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

PTHR11846:SF0
type: RelationshipXref
id: PTHR11846:SF0
db: PANTHER Family
relationship type: By Homology

Bifunctional purine biosynthesis protein ADE16
type: ProteinReference
xref: uniprot P54113 201
organism: Saccharomyces cerevisiae

Ribonucleoside-diphosphate reductase small chain 2
type: ProteinReference
xref: uniprot P49723 426
organism: Saccharomyces cerevisiae

uniprot Q9Y5B8 154
type: UnificationXref
id: Q9Y5B8
db: uniprot

Ribonucleotide reductase regulatory TP53 inducible subunit M2B
type: ProteinReference
xref: uniprot E1BFQ8 389
organism: Bos taurus

uniprot Q5BHB3 448
type: UnificationXref
id: Q5BHB3
db: uniprot

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q9Y0Y2 132
xref: PTHR11846:SF0
organism: Drosophila melanogaster

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot P21900 96
xref: PTHR11846:SF0
organism: Dictyostelium discoideum

Inosine-5'-monophosphate dehydrogenase 1a
type: ProteinReference
xref: uniprot Q6GMG5 253
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BDQ6 136
organism: Bos taurus

uniprot A8XQX9 272
type: UnificationXref
id: A8XQX9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QBQ1 350
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r4 647
type: Stoichiometry
physical entity: 5-phosphoribosyl N-formyl glycineamide
stoichiometric coefficient: 1.0

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P49915 362
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r4 648
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 649
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

uniprot P12268 236
type: UnificationXref
id: P12268
db: uniprot

STATE_TRANSITION_LEFT__5_phosphoribosoyl_glycineamide-RIGHT__5_phosphoribosyl_N_formyl_glycineamide-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 656
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 655
left: 5-phosphoribosoyl glycineamide
interaction type: STATE_TRANSITION
right: 5-phosphoribosyl N-formyl glycineamide

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: uniprot Q64737 560
organism: Mus musculus

uniprot E1C4Q0 391
type: UnificationXref
id: E1C4Q0
db: uniprot

uniprot Q9VIE7 382
type: UnificationXref
id: Q9VIE7
db: uniprot

STATE_TRANSITION_LEFT__glutamine-_PRPP-_H2O-RIGHT__PPi-_glutamate-_5_phosphoribosylamine-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 665
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 667
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 668
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 666
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 663
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 664
left: PRPP
left: glutamine
left: H2O
interaction type: STATE_TRANSITION
right: 5-phosphoribosylamine
right: PPi
right: glutamate

ncbitaxon 243274 130
type: UnificationXref
id: 243274
db: ncbitaxon

GTP:AMP phosphotransferase AK3, mitochondrial
type: ProteinReference
xref: uniprot Q9UIJ7 340
organism: Homo sapiens

Adenylate kinase
type: ProteinReference
xref: uniprot Q9HPA7 334
organism: Halobacterium salinarum

uniprot G3V918 546
type: UnificationXref
id: G3V918
db: uniprot

ncbitaxon 208964 64
type: UnificationXref
id: 208964
db: ncbitaxon

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot P0AG16 505
organism: Escherichia coli

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot F1MSF1 394
organism: Bos taurus

Ox FlR
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanylate kinase 2
type: ProteinReference
xref: uniprot Q9M682 491
organism: Arabidopsis thaliana

uniprot Q8IDF6 117
type: UnificationXref
id: Q8IDF6
db: uniprot

GDP reductase
type: Protein
entity reference: GDP reductase
comment: SPECIES_TYPE=PROTEIN

uniprot Q8N142 119
type: UnificationXref
id: Q8N142
db: uniprot

uniprot O35567 193
type: UnificationXref
id: O35567
db: uniprot

uniprot O84508 27
type: UnificationXref
id: O84508
db: uniprot

PARTICIPANT STOICHIOMETRY r23 680
type: Stoichiometry
physical entity: dADP
stoichiometric coefficient: 1.0

uniprot P15532 32
type: UnificationXref
id: P15532
db: uniprot

ncbitaxon 10116 14
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot F1QQX1 139
type: UnificationXref
id: F1QQX1
db: uniprot

uniprot F1Q9U6 90
type: UnificationXref
id: F1Q9U6
db: uniprot

PARTICIPANT STOICHIOMETRY r12 634
type: Stoichiometry
physical entity: 10-Formyl-THF
stoichiometric coefficient: 1.0

uniprot Q9STG9 527
type: UnificationXref
id: Q9STG9
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q8RE86 256
organism: Fusobacterium nucleatum

PARTICIPANT STOICHIOMETRY r23 681
type: Stoichiometry
physical entity: RS-SR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 635
type: Stoichiometry
physical entity: 5-phosphoribosoyl glycineamide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 636
type: Stoichiometry
physical entity: 5-phosphoribosyl N-formyl glycineamide
stoichiometric coefficient: 1.0

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q8TJ18 177
organism: Methanosarcina acetivorans

PARTICIPANT STOICHIOMETRY r12 637
type: Stoichiometry
physical entity: THF
stoichiometric coefficient: 1.0

Adenylosuccinate synthase
type: Protein
entity reference: Adenylosuccinate synthase
comment: SPECIES_TYPE=PROTEIN

Probable adenylate kinase 1, chloroplastic
type: ProteinReference
xref: uniprot Q10S93 311
organism: Oryza sativa

uniprot Q9Y0Y2 132
type: UnificationXref
id: Q9Y0Y2
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 7

uniprot Q06203 509
type: UnificationXref
id: Q06203
db: uniprot

5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase
type: Protein
entity reference: 5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9RKL4 570
type: UnificationXref
id: Q9RKL4
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P49740 44
organism: Schizosaccharomyces pombe

uniprot Q9XD15 346
type: UnificationXref
id: Q9XD15
db: uniprot

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 77

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot A0A1D5PSI2 218
organism: Gallus gallus

uniprot A8XRH8 189
type: UnificationXref
id: A8XRH8
db: uniprot

Adenylate kinase 2, mitochondrial
type: ProteinReference
xref: uniprot P54819 302
organism: Homo sapiens

DS cell adhesion molecule like 1
type: ProteinReference
xref: uniprot H2Q4V0 539
organism: Pan troglodytes

Ribonucleotide reductase regulatory subunit M2
type: ProteinReference
xref: uniprot E2R7H9 392
organism: Canis lupus familiaris

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot O14344 233
organism: Schizosaccharomyces pombe

Adenylosuccinate synthetase isozyme 1
type: ProteinReference
xref: PTHR11846:SF2
xref: uniprot P28650 97
organism: Mus musculus

IMP dehydrogenase
type: ProteinReference
xref: P02895
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: IMP dehydrogenase Synonym: Synonym not specified Accession: P02895
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.IMP dehydrogenase
member entity reference: Inosine-5'-monophosphate dehydrogenase
member entity reference: Inosine-5'-monophosphate dehydrogenase 1
member entity reference: Inosine-5'-monophosphate dehydrogenase 2
member entity reference: Inosine-5'-monophosphate dehydrogenase 1b
member entity reference: Inosine-5'-monophosphate dehydrogenase 1a
member entity reference: Inosine-5'-monophosphate dehydrogenase 4
member entity reference: Uncharacterized oxidoreductase Rv1843c
member entity reference: Inosine-5'-monophosphate dehydrogenase (Fragment)
member entity reference: Putative inosine monophosphate dehydrogenase
member entity reference: Inosine-5'-monophosphate dehydrogenase 3

uniprot Q8REV6 207
type: UnificationXref
id: Q8REV6
db: uniprot

PARTICIPANT STOICHIOMETRY r7 613
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Burgundy, isoform B
type: ProteinReference
xref: uniprot Q9VIE7 382
organism: Drosophila melanogaster

ncbitaxon 9615 18
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q57657 514
type: UnificationXref
id: Q57657
db: uniprot

PARTICIPANT STOICHIOMETRY r7 615
type: Stoichiometry
physical entity: phosphoribosyl carboxy aminoimidazole
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 614
type: Stoichiometry
physical entity: aspartate
stoichiometric coefficient: 1.0

ncbitaxon 9258 9
type: UnificationXref
id: 9258
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r7 617
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 616
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 618
type: Stoichiometry
physical entity: 5-phosphoribosyl-4-(N-succino-carboxyamide)-5-aminoimidazol
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 677
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 678
type: Stoichiometry
physical entity: RSH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r23 679
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Adenylosuccinate synthase
type: ProteinReference
xref: P02890
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.Adenylosuccinate synthase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Adenylosuccinate synthase Synonym: Synonym not specified Accession: P02890
member entity reference: Adenylosuccinate synthetase, chloroplastic
member entity reference: Adenylosuccinate synthetase isozyme 2
member entity reference: Adenylosuccinate synthetase
member entity reference: Adenylosuccinate synthetase isozyme 1
member entity reference: Adenylosuccinate synthetase 2
member entity reference: Adenylosuccinate synthetase 1, chloroplastic
member entity reference: Adenylosuccinate synthetase 1

Guanylate kinase
type: ProteinReference
xref: uniprot P9WKE9 483
organism: Mycobacterium tuberculosis

Ribonucleotide reductase
type: ProteinReference
xref: uniprot Q5BHB3 448
organism: Emericella nidulans

uniprot Q9QXL7 150
type: UnificationXref
id: Q9QXL7
db: uniprot

uniprot Q8L7W7 325
type: UnificationXref
id: Q8L7W7
db: uniprot

NAD
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot P12039 550
organism: Bacillus subtilis

P02906
type: UnificationXref
id: P02906
db: PANTHER Pathway Component

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q9RRW1 469
organism: Deinococcus radiodurans

ncbitaxon 272561 28
type: UnificationXref
id: 272561
db: ncbitaxon

P02905
type: UnificationXref
id: P02905
db: PANTHER Pathway Component

P02908
type: UnificationXref
id: P02908
db: PANTHER Pathway Component

P02907
type: UnificationXref
id: P02907
db: PANTHER Pathway Component

ncbitaxon 6238 7
type: UnificationXref
id: 6238
db: ncbitaxon

P02909
type: UnificationXref
id: P02909
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GWL3 282
organism: Macaca mulatta

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot F7GPV9 500
organism: Macaca mulatta

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot O60105 161
organism: Schizosaccharomyces pombe

P02900
type: UnificationXref
id: P02900
db: PANTHER Pathway Component

Adenylosuccinate synthetase isozyme 2
type: ProteinReference
xref: PTHR11846:SF13
xref: uniprot H2Q1F7 94
organism: Pan troglodytes

P02902
type: UnificationXref
id: P02902
db: PANTHER Pathway Component

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot F6UXI8 227
organism: Canis lupus familiaris

P02901
type: UnificationXref
id: P02901
db: PANTHER Pathway Component

uniprot Q6AZK9 65
type: UnificationXref
id: Q6AZK9
db: uniprot

Putative inosine monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9L0Z8 261
organism: Streptomyces coelicolor

P02904
type: UnificationXref
id: P02904
db: PANTHER Pathway Component

Ribonucleoside-diphosphate reductase (Fragment)
type: ProteinReference
xref: uniprot Q5TNU6 449
organism: Anopheles gambiae

uniprot H2QPI4 501
type: UnificationXref
id: H2QPI4
db: uniprot

uniprot E9PTV0 474
type: UnificationXref
id: E9PTV0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZS89 354
organism: Monodelphis domestica

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q8ZWY4 148
organism: Pyrobaculum aerophilum

uniprot Q9I514 569
type: UnificationXref
id: Q9I514
db: uniprot

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot Q8TQ86 458
organism: Methanosarcina acetivorans

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot F1MV22 498
organism: Bos taurus

uniprot Q05982 55
type: UnificationXref
id: Q05982
db: uniprot

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P29727 358
organism: Bacillus subtilis

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot P29726 98
xref: PTHR11846:SF0
organism: Bacillus subtilis

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q4QG35 109
organism: Leishmania major

uniprot P00568 290
type: UnificationXref
id: P00568
db: uniprot

Bifunctional purine biosynthesis protein PurH
type: ProteinReference
xref: uniprot P12048 196
organism: Bacillus subtilis

AICARFT/IMPCHase bienzyme family protein
type: ProteinReference
xref: uniprot Q8RWT5 208
organism: Arabidopsis thaliana

GTP:AMP phosphotransferase AK3, mitochondrial
type: ProteinReference
xref: uniprot E2RH37 278
organism: Canis lupus familiaris

N5-carboxyaminoimidazole ribonucleotide mutase
type: ProteinReference
xref: uniprot P12044 531
organism: Bacillus subtilis

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot O67321 95
xref: PTHR11846:SF0
organism: Aquifex aeolicus

uniprot Q7QHD0 254
type: UnificationXref
id: Q7QHD0
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot P12047 165
organism: Bacillus subtilis

P02911
type: UnificationXref
id: P02911
db: PANTHER Pathway Component

uniprot P0AB89 163
type: UnificationXref
id: P0AB89
db: uniprot

uniprot A0A0G2KGL2 542
type: UnificationXref
id: A0A0G2KGL2
db: uniprot

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: uniprot P22102 554
organism: Homo sapiens

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P9WMS7 363
organism: Mycobacterium tuberculosis

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 28

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 130

GTP:AMP phosphotransferase, mitochondrial
type: ProteinReference
xref: uniprot P26364 295
organism: Saccharomyces cerevisiae

RE29555p
type: ProteinReference
xref: uniprot Q9VC18 216
organism: Drosophila melanogaster

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot A3KN12 157
organism: Bos taurus

Adenylate kinase 1
type: ProteinReference
xref: uniprot P73302 305
organism: Synechocystis

uniprot P61136 48
type: UnificationXref
id: P61136
db: uniprot

Adenylate kinase
type: ProteinReference
xref: P02896
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.Adenylate kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Adenylate kinase Synonym: Synonym not specified Accession: P02896
member entity reference: Adenylate kinase 1, chloroplastic
member entity reference: Adenylate kinase
member entity reference: AGAP009660-PA
member entity reference: Adenylate kinase 1
member entity reference: Adenylate kinase isoenzyme 5
member entity reference: Adenylate kinase 2
member entity reference: Adenylate kinase, putative
member entity reference: GTP:AMP phosphotransferase, mitochondrial
member entity reference: Adenylate kinase isoenzyme 1
member entity reference: Adenylate kinase 4, mitochondrial
member entity reference: Adenylate kinase 4
member entity reference: Adenylate kinase 1, isoform B
member entity reference: Adenylate kinase 8
member entity reference: GTP:AMP phosphotransferase AK3, mitochondrial
member entity reference: Adenylate kinase 3
member entity reference: Adenylate kinase 2, mitochondrial
member entity reference: Adenylate kinase 5
member entity reference: AK5 isoform 1
member entity reference: UMP-CMP kinase 3
member entity reference: Probable adenylate kinase isoenzyme ZK673.2
member entity reference: GTP:AMP phosphotransferase
member entity reference: Uncharacterized protein
member entity reference: Putative adenylate kinase
member entity reference: Protein CBG03104
member entity reference: UMP-CMP kinase 4
member entity reference: Probable adenylate kinase 6, chloroplastic
member entity reference: Probable adenylate kinase 7, mitochondrial
member entity reference: Probable UMP-CMP kinase 1
member entity reference: Probable adenylate kinase 1, chloroplastic

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q384N4 445
organism: Trypanosoma brucei

uniprot Q9R0Y5 336
type: UnificationXref
id: Q9R0Y5
db: uniprot

uniprot P12039 550
type: UnificationXref
id: P12039
db: uniprot

uniprot P00452 410
type: UnificationXref
id: P00452
db: uniprot

uniprot F6ZS89 354
type: UnificationXref
id: F6ZS89
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_aspartate-_phosphoribosyl_carboxy_aminoimidazole-RIGHT__PO4-_ADP-_5_phosphoribosyl_4__N_succino_carboxyamide__5_aminoimidazol-_r7
controller: N5-carboxyaminoimidazole ribonucleotide mutase

uniprot O67236 502
type: UnificationXref
id: O67236
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot J9NSB4 142
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Ox_FlR-_dATP-RIGHT__Red_FlR-_ATP-_r25
controller: ATP reductase

uniprot P08760 293
type: UnificationXref
id: P08760
db: uniprot

STATE_TRANSITION_LEFT__glutamine-_H2O-_xanthosine_5_phosphate-_ATP-RIGHT__glutamate-_PPi-_GMP-_AMP-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 619
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 623
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 620
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 625
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 626
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 624
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 622
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 621
left: glutamine
left: ATP
left: H2O
left: xanthosine-5-phosphate
interaction type: STATE_TRANSITION
right: PPi
right: glutamate
right: GMP
right: AMP

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glutamine-_H2O-_xanthosine_5_phosphate-_ATP-RIGHT__glutamate-_PPi-_GMP-_AMP-_r14
controller: GMP synthase

uniprot Q9RUF5 571
type: UnificationXref
id: Q9RUF5
db: uniprot

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 275

Adenylate kinase
type: ProteinReference
xref: uniprot O66490 288
organism: Aquifex aeolicus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 84

N5-carboxyaminoimidazole ribonucleotide mutase
type: ProteinReference
xref: uniprot Q8REV0 534
organism: Fusobacterium nucleatum

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8REV2 519
organism: Fusobacterium nucleatum

uniprot Q7QEW3 516
type: UnificationXref
id: Q7QEW3
db: uniprot

Bifunctional purine biosynthesis protein PurH
type: ProteinReference
xref: uniprot Q8REV6 207
organism: Fusobacterium nucleatum

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot Q8REV7 562
organism: Fusobacterium nucleatum

uniprot P33075 299
type: UnificationXref
id: P33075
db: uniprot

ncbitaxon 189518 347
type: UnificationXref
id: 189518
db: ncbitaxon

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot P80210 104
xref: PTHR11846:SF0
organism: Saccharomyces cerevisiae

uniprot Q7PSP6 486
type: UnificationXref
id: Q7PSP6
db: uniprot

uniprot Q86L14 206
type: UnificationXref
id: Q86L14
db: uniprot

Bifunctional purine biosynthesis protein ade10
type: ProteinReference
xref: uniprot O74928 195
organism: Schizosaccharomyces pombe

uniprot P0ADG7 235
type: UnificationXref
id: P0ADG7
db: uniprot

uniprot Q58339 171
type: UnificationXref
id: Q58339
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 92

ncbitaxon 5722 270
type: UnificationXref
id: 5722
db: ncbitaxon

uniprot Q8ZY28 178
type: UnificationXref
id: Q8ZY28
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GGT3 400
organism: Monodelphis domestica

Adenylosuccinate synthetase isozyme 2
type: ProteinReference
xref: PTHR11846:SF13
xref: uniprot A7MBG0 87
organism: Bos taurus

uniprot Q9RSE6 181
type: UnificationXref
id: Q9RSE6
db: uniprot

Adenylate kinase 8
type: ProteinReference
xref: uniprot Q68FP8 317
organism: Rattus norvegicus

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot P35433 506
organism: Rattus norvegicus

Ribonucleoside-diphosphate reductase subunit M2 B
type: ProteinReference
xref: uniprot Q6PEE3 451
organism: Mus musculus

uniprot Q9L0I7 260
type: UnificationXref
id: Q9L0I7
db: uniprot

N5-carboxyaminoimidazole ribonucleotide synthase
type: Protein
entity reference: N5-carboxyaminoimidazole ribonucleotide synthase
comment: SPECIES_TYPE=PROTEIN

uniprot Q5E9Y9 146
type: UnificationXref
id: Q5E9Y9
db: uniprot

Anaerobic ribonucleoside-triphosphate reductase
type: ProteinReference
xref: uniprot Q8TUJ5 188
organism: Methanosarcina acetivorans

uniprot Q9Y6K8 348
type: UnificationXref
id: Q9Y6K8
db: uniprot

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P32073 359
organism: Dictyostelium discoideum

uniprot F6S675 226
type: UnificationXref
id: F6S675
db: uniprot

Guanylate kinase
type: ProteinReference
xref: uniprot P60546 479
organism: Escherichia coli

uniprot P74741 202
type: UnificationXref
id: P74741
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GDP-_RSH-RIGHT__dGDP-_H2O-_RSSR-_r17
controller: GDP reductase

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot P91134 105
xref: PTHR11846:SF0
organism: Caenorhabditis elegans

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot Q9HT76 464
organism: Pseudomonas aeruginosa

uniprot Q7QIX6 67
type: UnificationXref
id: Q7QIX6
db: uniprot

uniprot Q07152 246
type: UnificationXref
id: Q07152
db: uniprot

uniprot F6ZLV0 229
type: UnificationXref
id: F6ZLV0
db: uniprot

Guanylate kinase
type: ProteinReference
xref: uniprot Q9P6I5 492
organism: Schizosaccharomyces pombe

uniprot Q9I4I2 466
type: UnificationXref
id: Q9I4I2
db: uniprot

uniprot Q4QG35 109
type: UnificationXref
id: Q4QG35
db: uniprot

De novo purine biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__10_Formyl_THF-_5_phosphoribosoyl_glycineamide-RIGHT__5_phosphoribosyl_N_formyl_glycineamide-_THF-_r12
pathway component: STATE_TRANSITION_LEFT__GTP-_Aspartate-_IMP-RIGHT__PO4-_GDP-_adenylo_succinate-_r20
pathway component: STATE_TRANSITION_LEFT__5_phosphoribosoyl_glycineamide-RIGHT__5_phosphoribosyl_N_formyl_glycineamide-_r3
pathway component: STATE_TRANSITION_LEFT__glutamine-_PRPP-_H2O-RIGHT__PPi-_glutamate-_5_phosphoribosylamine-_r1
pathway component: STATE_TRANSITION_LEFT__phosphoribosyl_formamido_carboxamide-RIGHT__H2O-_IMP-_r10
pathway component: STATE_TRANSITION_LEFT__GDP-_ATP-RIGHT__ADP-_GTP-_r16
pathway component: STATE_TRANSITION_LEFT__glutamine-_H2O-_xanthosine_5_phosphate-_ATP-RIGHT__glutamate-_PPi-_GMP-_AMP-_r14
pathway component: STATE_TRANSITION_LEFT__adenylo_succinate-RIGHT__AMP-_fumarate-_r21
pathway component: STATE_TRANSITION_LEFT__N5_carboxyamino_imidazol_ribonucleotide-RIGHT__phosphoribosyl_carboxy_aminoimidazole-_r6
pathway component: STATE_TRANSITION_LEFT__5_phosphoribosyl_4__N_succino_carboxyamide__5_aminoimidazol-RIGHT__fumarate-_5_phosphoribosyl_5_amino_4_imidazole-_r8
pathway component: STATE_TRANSITION_LEFT__5_phosphoribosyl_5_aminoimidazole-_H2O-_CO2-_ATP-RIGHT__ADP-_PO4-_N5_carboxyamino_imidazol_ribonucleotide-_r5
pathway component: STATE_TRANSITION_LEFT__GMP-_ATP-RIGHT__ADP-_GDP-_r15
pathway component: STATE_TRANSITION_LEFT__Ox_FlR-_dATP-RIGHT__Red_FlR-_ATP-_r25
pathway component: STATE_TRANSITION_LEFT__5_phosphoribosyl_5_amino_4_imidazole-_10_formyl_THF-RIGHT__phosphoribosyl_formamido_carboxamide-_THF-_r9
pathway component: STATE_TRANSITION_LEFT__ATP-_dADP-RIGHT__ADP-_dATP-_r24
pathway component: STATE_TRANSITION_LEFT__glycine-_5_phosphoribosylamine-_ATP-RIGHT__PO4-_ADP-_5_phosphoribosoyl_glycineamide-_r2
pathway component: STATE_TRANSITION_LEFT__NAD-_H2O-_IMP-RIGHT__NADH-_xanthosine_5_phosphate-_r13
pathway component: STATE_TRANSITION_LEFT__ADP-_RSH-RIGHT__H2O-_dADP-_RS_SR-_r23
pathway component: STATE_TRANSITION_LEFT__GDP-_RSH-RIGHT__dGDP-_H2O-_RSSR-_r17
pathway component: STATE_TRANSITION_LEFT__ATP-_aspartate-_phosphoribosyl_carboxy_aminoimidazole-RIGHT__PO4-_ADP-_5_phosphoribosyl_4__N_succino_carboxyamide__5_aminoimidazol-_r7
pathway component: STATE_TRANSITION_LEFT__5_phosphoribosyl_N_formyl_glycineamide-_ATP-RIGHT__PO4-_ADP-_5_phosphoribosyl_5_aminoimidazole-_r4
pathway component: STATE_TRANSITION_LEFT__GTP-_Red_FlR-RIGHT__dGTP-_Ox_FlR-_r18
pathway component: STATE_TRANSITION_LEFT__5_phosphoribosoyl_glycineamide-RIGHT__5_phosphoribosyl_N_formyl_glycineamide-_r11
pathway component: STATE_TRANSITION_LEFT__dGDP-_ATP-RIGHT__ADP-_dGTP-_r19
pathway component: STATE_TRANSITION_LEFT__AMP-_ATP-RIGHT__ADP-_r22
xref: PANTHER Pathway P02738 1
comment: MODEL_NOTES=The de novo biosynthesis of purine deoxyribonucleotides, the monomeric units of DNA. Website=www.biocyc.org/Ecoli free text=Voet and Voet (textbook) Biochemistry

uniprot O84834 408
type: UnificationXref
id: O84834
db: uniprot

uniprot Q95QQ4 210
type: UnificationXref
id: Q95QQ4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dGDP-_ATP-RIGHT__ADP-_dGTP-_r19
controller: dGDP kinase

ncbitaxon 44689 37
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot E2RE39 276
type: UnificationXref
id: E2RE39
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q59011 249
organism: Methanocaldococcus jannaschii

ncbitaxon 188937 75
type: UnificationXref
id: 188937
db: ncbitaxon

uniprot O00746 20
type: UnificationXref
id: O00746
db: uniprot

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot P38625 360
organism: Saccharomyces cerevisiae

uniprot Q16774 484
type: UnificationXref
id: Q16774
db: uniprot

Adenylate kinase isoenzyme 1
type: ProteinReference
xref: uniprot P00570 291
organism: Bos taurus

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q9U0T7 182
organism: Leishmania major

uniprot A0A2I3T5C3 266
type: UnificationXref
id: A0A2I3T5C3
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot F1QQX1 139
organism: Danio rerio

uniprot Q381H3 59
type: UnificationXref
id: Q381H3
db: uniprot

uniprot Q6K7H2 318
type: UnificationXref
id: Q6K7H2
db: uniprot

uniprot F6U4A0 397
type: UnificationXref
id: F6U4A0
db: uniprot

uniprot P21900 96
type: UnificationXref
id: P21900
db: uniprot

uniprot P36602 418
type: UnificationXref
id: P36602
db: uniprot

STATE_TRANSITION_LEFT__10_Formyl_THF-_5_phosphoribosoyl_glycineamide-RIGHT__5_phosphoribosyl_N_formyl_glycineamide-_THF-_r12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 636
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 635
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 637
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 634
left: 5-phosphoribosoyl glycineamide
left: 10-Formyl-THF
interaction type: STATE_TRANSITION
right: THF
right: 5-phosphoribosyl N-formyl glycineamide

uniprot D4AEP0 88
type: UnificationXref
id: D4AEP0
db: uniprot

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: uniprot A0A2I3T1L1 543
organism: Pan troglodytes

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q8IL94 454
organism: Plasmodium falciparum

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot O84508 27
organism: Chlamydia trachomatis

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 347

glycine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__GMP-_ATP-RIGHT__ADP-_GDP-_r15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 610
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 612
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 609
participant stoichiometry: PARTICIPANT STOICHIOMETRY r15 611
left: ATP
left: GMP
interaction type: STATE_TRANSITION
right: GDP
right: ADP

Adenylate kinase isoenzyme 1
type: ProteinReference
xref: uniprot P00568 290
organism: Homo sapiens

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 128

uniprot Q8TRS3 327
type: UnificationXref
id: Q8TRS3
db: uniprot

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q5VRF5 450
organism: Oryza sativa

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: uniprot Q7Q1H5 561
organism: Anopheles gambiae

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot F6Z9D7 398
organism: Macaca mulatta

uniprot P07742 411
type: UnificationXref
id: P07742
db: uniprot

GTP:AMP phosphotransferase AK3, mitochondrial
type: ProteinReference
xref: uniprot P08760 293
organism: Bos taurus

GMP synthase
type: ProteinReference
xref: P02899
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: GMP synthase Synonym: Synonym not specified Accession: P02899
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.GMP synthase
member entity reference: GMP synthase [glutamine-hydrolyzing]
member entity reference: GMP synthase [glutamine-hydrolyzing] subunit B
member entity reference: Uncharacterized protein
member entity reference: Burgundy, isoform B
member entity reference: GMP synthase [glutamine-hydrolyzing] subunit A
member entity reference: Guanine monophosphate synthase
member entity reference: At1g63660
member entity reference: AGAP010139-PA

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 62

uniprot Q59011 249
type: UnificationXref
id: Q59011
db: uniprot

uniprot Q9HPS4 524
type: UnificationXref
id: Q9HPS4
db: uniprot

uniprot P9WKI3 244
type: UnificationXref
id: P9WKI3
db: uniprot

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot Q9HMU3 461
organism: Halobacterium salinarum

Ribonucleoside reductase small chain
type: ProteinReference
xref: uniprot Q9HMU4 462
organism: Halobacterium salinarum

PARTICIPANT STOICHIOMETRY r21 576
type: Stoichiometry
physical entity: adenylo-succinate
stoichiometric coefficient: 1.0

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 23

Bifunctional purine biosynthesis protein PURH
type: ProteinReference
xref: uniprot O35567 193
organism: Rattus norvegicus

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot P74732 432
organism: Synechocystis

uniprot Q9KY50 214
type: UnificationXref
id: Q9KY50
db: uniprot

uniprot O14344 233
type: UnificationXref
id: O14344
db: uniprot

PARTICIPANT STOICHIOMETRY r21 578
type: Stoichiometry
physical entity: fumarate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r21 577
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

ncbitaxon 39947 57
type: UnificationXref
id: 39947
db: ncbitaxon

ncbitaxon 7165 68
type: UnificationXref
id: 7165
db: ncbitaxon

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q7QIX6 67
organism: Anopheles gambiae

uniprot P24547 238
type: UnificationXref
id: P24547
db: uniprot

uniprot Q64520 485
type: UnificationXref
id: Q64520
db: uniprot

STATE_TRANSITION_LEFT__AMP-_ATP-RIGHT__ADP-_r22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 574
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 573
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 575
left: ATP
left: AMP
interaction type: STATE_TRANSITION
right: ADP

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q8GUN7 174
organism: Arabidopsis thaliana

STATE_TRANSITION_LEFT__adenylo_succinate-RIGHT__AMP-_fumarate-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 577
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 578
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 576
left: adenylo-succinate
interaction type: STATE_TRANSITION
right: fumarate
right: AMP

uniprot Q9HTM2 489
type: UnificationXref
id: Q9HTM2
db: uniprot

Inosine-5'-monophosphate dehydrogenase 1
type: ProteinReference
xref: uniprot A0JNA3 221
organism: Bos taurus

uniprot Q9RXT6 525
type: UnificationXref
id: Q9RXT6
db: uniprot

fumarate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 53

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q8I2U5 255
organism: Plasmodium falciparum

uniprot A0A1D5PSI2 218
type: UnificationXref
id: A0A1D5PSI2
db: uniprot

RSSR
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Trichomonas vaginalis
type: BioSource
xref: ncbitaxon 5722 270

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q967S0 523
organism: Drosophila melanogaster

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 164

Danio rerio
type: BioSource
xref: ncbitaxon 7955 3

Nucleoside diphosphate kinase 3
type: ProteinReference
xref: uniprot Q13232 58
organism: Homo sapiens

uniprot O66856 162
type: UnificationXref
id: O66856
db: uniprot

uniprot J9NSB4 142
type: UnificationXref
id: J9NSB4
db: uniprot

GTP reductase
type: ProteinReference
xref: P02897
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: GTP reductase Synonym: Synonym not specified Accession: P02897
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.GTP reductase
member entity reference: Anaerobic ribonucleoside-triphosphate reductase

Nucleoside diphosphate kinase 3
type: ProteinReference
xref: uniprot Q9WV85 82
organism: Mus musculus

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9HQU4 258
organism: Halobacterium salinarum

uniprot Q9HXM6 378
type: UnificationXref
id: Q9HXM6
db: uniprot

uniprot Q8F649 533
type: UnificationXref
id: Q8F649
db: uniprot

Nucleoside diphosphate kinase, mitochondrial
type: ProteinReference
xref: uniprot O00746 20
organism: Homo sapiens

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q9X2E0 383
organism: Thermotoga maritima

Nucleoside diphosphate kinase 7
type: ProteinReference
xref: uniprot Q5E9Y9 146
organism: Bos taurus

N5-carboxyaminoimidazole ribonucleotide mutase
type: ProteinReference
xref: uniprot Q8F649 533
organism: Leptospira interrogans

uniprot Q4Q3J6 315
type: UnificationXref
id: Q4Q3J6
db: uniprot

uniprot Q6GMG5 253
type: UnificationXref
id: Q6GMG5
db: uniprot

uniprot P79732 433
type: UnificationXref
id: P79732
db: uniprot

PARTICIPANT STOICHIOMETRY r10 653
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 652
type: Stoichiometry
physical entity: phosphoribosyl-formamido-carboxamide
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__GDP-_RSH-RIGHT__dGDP-_H2O-_RSSR-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 593
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 597
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 595
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 596
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 594
left: RSH
left: GDP
interaction type: STATE_TRANSITION
right: H2O
right: RSSR
right: dGDP

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot R9PXW5 155
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r10 654
type: Stoichiometry
physical entity: IMP
stoichiometric coefficient: 1.0

aspartate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9M682 491
type: UnificationXref
id: Q9M682
db: uniprot

UMP-CMP kinase 3
type: ProteinReference
xref: uniprot Q7XI40 321
organism: Oryza sativa

Guanylate kinase
type: ProteinReference
xref: uniprot Q8RHI9 487
organism: Fusobacterium nucleatum

uniprot Q8TQ86 458
type: UnificationXref
id: Q8TQ86
db: uniprot

uniprot Q8REV7 562
type: UnificationXref
id: Q8REV7
db: uniprot

Ribonucleoside-diphosphate reductase large chain 1
type: ProteinReference
xref: uniprot P21524 414
organism: Saccharomyces cerevisiae

uniprot A8XST9 496
type: UnificationXref
id: A8XST9
db: uniprot

uniprot F1MSF1 394
type: UnificationXref
id: F1MSF1
db: uniprot

uniprot Q8RGD3 175
type: UnificationXref
id: Q8RGD3
db: uniprot

GMP synthase [glutamine-hydrolyzing] subunit B
type: ProteinReference
xref: uniprot Q9HP33 376
organism: Halobacterium salinarum

uniprot Q9P6I5 492
type: UnificationXref
id: Q9P6I5
db: uniprot

IMP dehydrogenase
type: Protein
entity reference: IMP dehydrogenase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 5759 275
type: UnificationXref
id: 5759
db: ncbitaxon

uniprot Q9HPA7 334
type: UnificationXref
id: Q9HPA7
db: uniprot

uniprot P23921 416
type: UnificationXref
id: P23921
db: uniprot

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q9X8P6 131
xref: PTHR11846:SF0
organism: Streptomyces coelicolor

ncbitaxon 237561 251
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot Q9CAD1 375
type: UnificationXref
id: Q9CAD1
db: uniprot

STATE_TRANSITION_LEFT__5_phosphoribosyl_5_aminoimidazole-_H2O-_CO2-_ATP-RIGHT__ADP-_PO4-_N5_carboxyamino_imidazol_ribonucleotide-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 643
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 642
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 640
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 644
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 639
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 638
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 641
left: ATP
left: H2O
left: 5-phosphoribosyl-5-aminoimidazole
left: CO2
interaction type: STATE_TRANSITION
right: PO4
right: N5-carboxyamino imidazol ribonucleotide
right: ADP

ncbitaxon 243232 62
type: UnificationXref
id: 243232
db: ncbitaxon

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot E2RF42 497
organism: Canis lupus familiaris

uniprot Q9X2E0 383
type: UnificationXref
id: Q9X2E0
db: uniprot

uniprot F7GWL3 282
type: UnificationXref
id: F7GWL3
db: uniprot

uniprot H2Q1F7 94
type: UnificationXref
id: H2Q1F7
db: uniprot

Adenylate kinase
type: ProteinReference
xref: uniprot P16304 294
organism: Bacillus subtilis

uniprot Q58347 559
type: UnificationXref
id: Q58347
db: uniprot

Ribonucleoside-diphosphate reductase subunit alpha
type: ProteinReference
xref: uniprot P74240 431
organism: Synechocystis

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q58339 171
organism: Methanocaldococcus jannaschii

STATE_TRANSITION_LEFT__dGDP-_ATP-RIGHT__ADP-_dGTP-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 586
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 585
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 588
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 587
left: ATP
left: dGDP
interaction type: STATE_TRANSITION
right: dGTP
right: ADP

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot Q9RUF5 571
organism: Deinococcus radiodurans

uniprot P21524 414
type: UnificationXref
id: P21524
db: uniprot

uniprot Q9UIJ7 340
type: UnificationXref
id: Q9UIJ7
db: uniprot

uniprot Q9HP33 376
type: UnificationXref
id: Q9HP33
db: uniprot

Adenylate kinase isoenzyme 1
type: ProteinReference
xref: uniprot B4YY02 273
organism: Canis lupus familiaris

RSH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P31350 417
type: UnificationXref
id: P31350
db: uniprot

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q4V7C6 365
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NAD-_H2O-_IMP-RIGHT__NADH-_xanthosine_5_phosphate-_r13
controller: IMP dehydrogenase

uniprot P73290 103
type: UnificationXref
id: P73290
db: uniprot

Probable adenylate kinase 6, chloroplastic
type: ProteinReference
xref: uniprot Q84JF7 322
organism: Arabidopsis thaliana

uniprot Q9WUR9 344
type: UnificationXref
id: Q9WUR9
db: uniprot

Ribonucleoside-diphosphate reductase 2 subunit alpha
type: ProteinReference
xref: uniprot P39452 421
organism: Escherichia coli

Inosine-5'-monophosphate dehydrogenase 1
type: ProteinReference
xref: uniprot D3ZLZ7 224
organism: Rattus norvegicus

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: uniprot Q4KLN6 446
organism: Rattus norvegicus

uniprot Q58531 366
type: UnificationXref
id: Q58531
db: uniprot

uniprot H9FTL1 141
type: UnificationXref
id: H9FTL1
db: uniprot

ncbitaxon 227321 73
type: UnificationXref
id: 227321
db: ncbitaxon

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 14

ncbitaxon 10090 33
type: UnificationXref
id: 10090
db: ncbitaxon

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot F6TKJ2 396
organism: Xenopus tropicalis

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot O67528 25
organism: Aquifex aeolicus

uniprot Q20140 312
type: UnificationXref
id: Q20140
db: uniprot

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot P74232 556
organism: Synechocystis

uniprot P52420 555
type: UnificationXref
id: P52420
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q07152 246
organism: Drosophila melanogaster

uniprot Q03604 439
type: UnificationXref
id: Q03604
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DFY8 191
organism: Macaca mulatta

Guanylate kinase
type: ProteinReference
xref: uniprot O84033 476
organism: Chlamydia trachomatis

uniprot Q9SI61 526
type: UnificationXref
id: Q9SI61
db: uniprot

Adenylate kinase isoenzyme 5
type: ProteinReference
xref: uniprot Q920P5 330
organism: Mus musculus

uniprot P38009 200
type: UnificationXref
id: P38009
db: uniprot

PRPP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RZL6 470
type: UnificationXref
id: Q9RZL6
db: uniprot

Adenylate kinase 4, mitochondrial
type: ProteinReference
xref: uniprot Q9WUR9 344
organism: Mus musculus

uniprot Q8RH18 457
type: UnificationXref
id: Q8RH18
db: uniprot

uniprot Q8RE86 256
type: UnificationXref
id: Q8RE86
db: uniprot

5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase
type: ProteinReference
xref: P02892
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: 5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase Synonym: Synonym not specified Accession: P02892
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.5-Phosphoribosyl-4-_br_(N-succinocarboxamide)-_br_5-aminoimidazole lyase
member entity reference: Adenylosuccinate lyase
member entity reference: Adenylosuccinate lyase (PurB)

uniprot Q19599 440
type: UnificationXref
id: Q19599
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q7SXL4 69
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__10_Formyl_THF-_5_phosphoribosoyl_glycineamide-RIGHT__5_phosphoribosyl_N_formyl_glycineamide-_THF-_r12
controller: Phosphoribosylglycinamide formyltransferase

uniprot Q8ZZK3 522
type: UnificationXref
id: Q8ZZK3
db: uniprot

uniprot A0A2I3SX17 386
type: UnificationXref
id: A0A2I3SX17
db: uniprot

Phosphoribosylformylglycinamide cyclo-ligase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q09629 309
type: UnificationXref
id: Q09629
db: uniprot

Phosphoribosylamine--glycine ligase, chloroplastic
type: ProteinReference
xref: uniprot P52420 555
organism: Arabidopsis thaliana

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P50589 46
organism: Streptomyces coelicolor

Amidophosphoribosyltransferase 3, chloroplastic
type: ProteinReference
xref: uniprot Q9T0J5 528
organism: Arabidopsis thaliana

Adenylate kinase 5
type: ProteinReference
xref: uniprot E2REX1 277
organism: Canis lupus familiaris

uniprot P74732 432
type: UnificationXref
id: P74732
db: uniprot

uniprot Q9KXS0 490
type: UnificationXref
id: Q9KXS0
db: uniprot

uniprot P31335 198
type: UnificationXref
id: P31335
db: uniprot

Bifunctional purine biosynthetic protein ADE1
type: ProteinReference
xref: uniprot Q99148 565
organism: Yarrowia lipolytica

uniprot F1MV22 498
type: UnificationXref
id: F1MV22
db: uniprot

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: uniprot F1PTG8 544
organism: Canis lupus familiaris

Adenylate kinase isoenzyme 1
type: ProteinReference
xref: uniprot Q9R0Y5 336
organism: Mus musculus

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot J9P3S5 17
organism: Canis lupus familiaris

Bifunctional purine biosynthesis protein PurH
type: ProteinReference
xref: uniprot P15639 197
organism: Escherichia coli

uniprot D3ZPL7 537
type: UnificationXref
id: D3ZPL7
db: uniprot

uniprot Q9UUY8 80
type: UnificationXref
id: Q9UUY8
db: uniprot

uniprot P36603 419
type: UnificationXref
id: P36603
db: uniprot

uniprot Q8A4S9 532
type: UnificationXref
id: Q8A4S9
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q9RSE6 181
organism: Deinococcus radiodurans

Adenylate kinase 2
type: ProteinReference
xref: uniprot P72641 304
organism: Synechocystis

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q7XC37 70
organism: Oryza sativa

uniprot Q9HQU4 258
type: UnificationXref
id: Q9HQU4
db: uniprot

uniprot P04079 357
type: UnificationXref
id: P04079
db: uniprot

Guanylate kinase
type: ProteinReference
xref: uniprot P72648 480
organism: Synechocystis

STATE_TRANSITION_LEFT__GTP-_Aspartate-_IMP-RIGHT__PO4-_GDP-_adenylo_succinate-_r20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 583
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 581
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 582
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 584
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 580
participant stoichiometry: PARTICIPANT STOICHIOMETRY r20 579
left: IMP
left: Aspartate
left: GTP
interaction type: STATE_TRANSITION
right: PO4
right: adenylo-succinate
right: GDP

uniprot Q5JFM1 368
type: UnificationXref
id: Q5JFM1
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot F7DTY4 231
organism: Monodelphis domestica

uniprot P38697 239
type: UnificationXref
id: P38697
db: uniprot

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot P15640 551
organism: Escherichia coli

Inosine-5'-monophosphate dehydrogenase 2
type: ProteinReference
xref: uniprot F7CYY5 230
organism: Xenopus tropicalis

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9GZH3 257
organism: Caenorhabditis elegans

uniprot Q9I0K9 180
type: UnificationXref
id: Q9I0K9
db: uniprot

uniprot Q9WTP6 342
type: UnificationXref
id: Q9WTP6
db: uniprot

uniprot H2Q2Y0 402
type: UnificationXref
id: H2Q2Y0
db: uniprot

ncbitaxon 7955 3
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot Q08480 308
type: UnificationXref
id: Q08480
db: uniprot

Bifunctional purine biosynthetic protein ADE5,7
type: ProteinReference
xref: uniprot P07244 548
organism: Saccharomyces cerevisiae

Putative adenylate kinase
type: ProteinReference
xref: uniprot Q4QC71 316
organism: Leishmania major

uniprot Q5A0N3 447
type: UnificationXref
id: Q5A0N3
db: uniprot

N5-carboxyaminoimidazole ribonucleotide mutase
type: ProteinReference
xref: uniprot Q9RYC7 536
organism: Deinococcus radiodurans

uniprot P9WKI7 245
type: UnificationXref
id: P9WKI7
db: uniprot

uniprot Q9RRJ1 152
type: UnificationXref
id: Q9RRJ1
db: uniprot

uniprot Q4KLN6 446
type: UnificationXref
id: Q4KLN6
db: uniprot

Nucleoside diphosphate kinase B
type: ProteinReference
xref: uniprot P22392 35
organism: Homo sapiens

At1g63660
type: ProteinReference
xref: uniprot Q9CAD1 375
organism: Arabidopsis thaliana

uniprot F1Q4F5 89
type: UnificationXref
id: F1Q4F5
db: uniprot

ncbitaxon 9913 5
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot P29410 297
type: UnificationXref
id: P29410
db: uniprot

uniprot Q7Q0V2 369
type: UnificationXref
id: Q7Q0V2
db: uniprot

Nucleoside diphosphate kinase, mitochondrial
type: ProteinReference
xref: uniprot P34093 40
organism: Dictyostelium discoideum

Phosphoribosylglycinamide formyltransferase
type: ProteinReference
xref: uniprot A0A0G2KGL2 542
organism: Danio rerio

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q02787 107
xref: PTHR11846:SF0
organism: Schizosaccharomyces pombe

Nucleoside diphosphate kinase 1
type: ProteinReference
xref: uniprot P39207 43
organism: Arabidopsis thaliana

Bifunctional purine biosynthesis protein PurH
type: ProteinReference
xref: uniprot O67775 194
organism: Aquifex aeolicus

uniprot F1PTG8 544
type: UnificationXref
id: F1PTG8
db: uniprot

uniprot Q9T0J5 528
type: UnificationXref
id: Q9T0J5
db: uniprot

uniprot Q8RHI9 487
type: UnificationXref
id: Q8RHI9
db: uniprot

uniprot Q8ZWY4 148
type: UnificationXref
id: Q8ZWY4
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 73

GMP synthase [glutamine-hydrolyzing] subunit B
type: ProteinReference
xref: uniprot Q5JFM1 368
organism: Thermococcus kodakaraensis

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q9RYB5 127
xref: PTHR11846:SF0
organism: Deinococcus radiodurans

uniprot Q5BEY7 111
type: UnificationXref
id: Q5BEY7
db: uniprot

Adenosuccinate lyase
type: ProteinReference
xref: P02901
standard name: Adenylosuccinate lyase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.Adenosuccinate lyase
comment: ENTITY_REFERENCE_NOTES=Long Name: Adenylosuccinate lyase Synonym: Synonym not specified Accession: P02901
member entity reference: Adenylosuccinate lyase
member entity reference: Probable lyase
member entity reference: Adenylosuccinate lyase (PurB)

uniprot E1BDQ6 136
type: UnificationXref
id: E1BDQ6
db: uniprot

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q86A85 517
organism: Dictyostelium discoideum

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9HXM5 259
organism: Pseudomonas aeruginosa

uniprot F6V935 280
type: UnificationXref
id: F6V935
db: uniprot

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q9HXM6 378
organism: Pseudomonas aeruginosa

Adenylate kinase
type: ProteinReference
xref: uniprot P07170 292
organism: Saccharomyces cerevisiae

uniprot F6TWB9 8
type: UnificationXref
id: F6TWB9
db: uniprot

Ribonucleoside-diphosphate reductase 2 subunit beta
type: ProteinReference
xref: uniprot P37146 420
organism: Escherichia coli

uniprot Q9HUV8 568
type: UnificationXref
id: Q9HUV8
db: uniprot

uniprot O67321 95
type: UnificationXref
id: O67321
db: uniprot

uniprot J9P3S5 17
type: UnificationXref
id: J9P3S5
db: uniprot

PARTICIPANT STOICHIOMETRY r16 605
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot O67775 194
type: UnificationXref
id: O67775
db: uniprot

uniprot H2Q705 15
type: UnificationXref
id: H2Q705
db: uniprot

PARTICIPANT STOICHIOMETRY r16 602
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot F6ZLV0 229
organism: Ornithorhynchus anatinus

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot A5PK70 4
organism: Bos taurus

Bifunctional purine biosynthesis protein ADE17
type: ProteinReference
xref: uniprot P38009 200
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r16 604
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot E1BFQ8 389
type: UnificationXref
id: E1BFQ8
db: uniprot

PARTICIPANT STOICHIOMETRY r16 603
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot P23921 416
organism: Homo sapiens

GMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P31939 199
type: UnificationXref
id: P31939
db: uniprot

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot O69981 407
organism: Streptomyces coelicolor

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q9I4I1 465
organism: Pseudomonas aeruginosa

uniprot Q9HUM6 126
type: UnificationXref
id: Q9HUM6
db: uniprot

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot Q9I4I2 466
organism: Pseudomonas aeruginosa

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot P21879 237
organism: Bacillus subtilis

P02899
type: UnificationXref
id: P02899
db: PANTHER Pathway Component

Ribonucleoside-diphosphate reductase NrdEB subunit alpha
type: ProteinReference
xref: uniprot O31875 404
organism: Bacillus subtilis

uniprot A5PK70 4
type: UnificationXref
id: A5PK70
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q59636 63
organism: Pseudomonas aeruginosa

P02897
type: UnificationXref
id: P02897
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r14 619
type: Stoichiometry
physical entity: glutamine
stoichiometric coefficient: 1.0

P02890
type: UnificationXref
id: P02890
db: PANTHER Pathway Component

uniprot P50589 46
type: UnificationXref
id: P50589
db: uniprot

P02892
type: UnificationXref
id: P02892
db: PANTHER Pathway Component

P02891
type: UnificationXref
id: P02891
db: PANTHER Pathway Component

uniprot Q7XI40 321
type: UnificationXref
id: Q7XI40
db: uniprot

STATE_TRANSITION_LEFT__ATP-_aspartate-_phosphoribosyl_carboxy_aminoimidazole-RIGHT__PO4-_ADP-_5_phosphoribosyl_4__N_succino_carboxyamide__5_aminoimidazol-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 616
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 617
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 613
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 615
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 614
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 618
left: phosphoribosyl carboxy aminoimidazole
left: ATP
left: aspartate
interaction type: STATE_TRANSITION
right: 5-phosphoribosyl-4-(N-succino-carboxyamide)-5-aminoimidazol
right: PO4
right: ADP

uniprot P07244 548
type: UnificationXref
id: P07244
db: uniprot

P02894
type: UnificationXref
id: P02894
db: PANTHER Pathway Component

P02893
type: UnificationXref
id: P02893
db: PANTHER Pathway Component

P02896
type: UnificationXref
id: P02896
db: PANTHER Pathway Component

uniprot P22392 35
type: UnificationXref
id: P22392
db: uniprot

uniprot K7BSW8 19
type: UnificationXref
id: K7BSW8
db: uniprot

P02895
type: UnificationXref
id: P02895
db: PANTHER Pathway Component

IMP cyclohydrolase
type: Protein
entity reference: IMP cyclohydrolase
comment: SPECIES_TYPE=PROTEIN

Bifunctional purine biosynthesis protein purH
type: ProteinReference
xref: uniprot Q86L14 206
organism: Dictyostelium discoideum

uniprot Q7XC37 70
type: UnificationXref
id: Q7XC37
db: uniprot

uniprot H2R2P9 286
type: UnificationXref
id: H2R2P9
db: uniprot

uniprot P9WH73 436
type: UnificationXref
id: P9WH73
db: uniprot

uniprot P27144 296
type: UnificationXref
id: P27144
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1LUN6 351
organism: Bos taurus

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q51342 512
organism: Pseudomonas aeruginosa

ncbitaxon 9598 16
type: UnificationXref
id: 9598
db: ncbitaxon

N5-carboxyaminoimidazole ribonucleotide mutase
type: Protein
entity reference: N5-carboxyaminoimidazole ribonucleotide mutase
comment: SPECIES_TYPE=PROTEIN

uniprot F6Z9D7 398
type: UnificationXref
id: F6Z9D7
db: uniprot

GMP synthase [glutamine-hydrolyzing] subunit A
type: ProteinReference
xref: uniprot Q9HSH4 377
organism: Halobacterium salinarum

uniprot Q8RY94 176
type: UnificationXref
id: Q8RY94
db: uniprot

uniprot F6UXI8 227
type: UnificationXref
id: F6UXI8
db: uniprot

Adenylate kinase
type: ProteinReference
xref: uniprot C4M9S5 274
organism: Entamoeba histolytica

uniprot P93757 482
type: UnificationXref
id: P93757
db: uniprot

uniprot P19804 34
type: UnificationXref
id: P19804
db: uniprot

P02889
type: UnificationXref
id: P02889
db: PANTHER Pathway Component

uniprot P15639 197
type: UnificationXref
id: P15639
db: uniprot

uniprot F7GSL0 545
type: UnificationXref
id: F7GSL0
db: uniprot

uniprot P69441 303
type: UnificationXref
id: P69441
db: uniprot

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot O67475 406
organism: Aquifex aeolicus

uniprot P41390 507
type: UnificationXref
id: P41390
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 42

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 566

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 30

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot A8X1T4 222
organism: Caenorhabditis briggsae

Adenylate kinase
type: ProteinReference
xref: uniprot Q9XD15 346
organism: Leptospira interrogans

uniprot P42521 423
type: UnificationXref
id: P42521
db: uniprot

uniprot A8WSS5 271
type: UnificationXref
id: A8WSS5
db: uniprot

uniprot A5PJR4 86
type: UnificationXref
id: A5PJR4
db: uniprot

ncbitaxon 69014 113
type: UnificationXref
id: 69014
db: ncbitaxon

uniprot Q8RH17 456
type: UnificationXref
id: Q8RH17
db: uniprot

GMP synthase [glutamine-hydrolyzing] subunit B
type: ProteinReference
xref: uniprot Q8THK3 373
organism: Methanosarcina acetivorans

dATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Amidophosphoribosyltransferase (PurF)
type: ProteinReference
xref: uniprot Q8ZZK3 522
organism: Pyrobaculum aerophilum

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot Q8ZZK4 564
organism: Pyrobaculum aerophilum

uniprot Q9K496 468
type: UnificationXref
id: Q9K496
db: uniprot

uniprot Q5VRF5 450
type: UnificationXref
id: Q5VRF5
db: uniprot

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q9HUM6 126
xref: PTHR11846:SF0
organism: Pseudomonas aeruginosa

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P9U2 353
organism: Canis lupus familiaris

Guanylate kinase
type: ProteinReference
xref: uniprot Q16774 484
organism: Homo sapiens

ncbitaxon 3702 23
type: UnificationXref
id: 3702
db: ncbitaxon

UMP-CMP kinase 3
type: ProteinReference
xref: uniprot O04905 287
organism: Arabidopsis thaliana

uniprot Q6DI51 147
type: UnificationXref
id: Q6DI51
db: uniprot

uniprot Q8TR08 535
type: UnificationXref
id: Q8TR08
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q9I0K9 180
organism: Pseudomonas aeruginosa

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__adenylo_succinate-RIGHT__AMP-_fumarate-_r21
controller: Adenosuccinate lyase

STATE_TRANSITION_LEFT__phosphoribosyl_formamido_carboxamide-RIGHT__H2O-_IMP-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 652
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 654
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 653
left: phosphoribosyl-formamido-carboxamide
interaction type: STATE_TRANSITION
right: H2O
right: IMP

uniprot Q5RGV1 252
type: UnificationXref
id: Q5RGV1
db: uniprot

uniprot P9WH75 437
type: UnificationXref
id: P9WH75
db: uniprot

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot Q9K3C2 467
organism: Streptomyces coelicolor

uniprot Q9RYB5 127
type: UnificationXref
id: Q9RYB5
db: uniprot

uniprot P74494 50
type: UnificationXref
id: P74494
db: uniprot

uniprot Q38EC4 314
type: UnificationXref
id: Q38EC4
db: uniprot

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 118

uniprot P9WH71 435
type: UnificationXref
id: P9WH71
db: uniprot

uniprot Q967S0 523
type: UnificationXref
id: Q967S0
db: uniprot

PARTICIPANT STOICHIOMETRY r14 622
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Thermococcus kodakaraensis
type: BioSource
xref: ncbitaxon 69014 113

PARTICIPANT STOICHIOMETRY r14 621
type: Stoichiometry
physical entity: xanthosine-5-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 624
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 623
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8ZZJ6 521
organism: Pyrobaculum aerophilum

PARTICIPANT STOICHIOMETRY r14 620
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GMP-_ATP-RIGHT__ADP-_GDP-_r15
controller: Guanylate kinase

uniprot Q9X0I1 129
type: UnificationXref
id: Q9X0I1
db: uniprot

Ribonucleoside-diphosphate reductase small chain 1
type: ProteinReference
xref: uniprot P09938 412
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r14 626
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q8RH18 457
organism: Fusobacterium nucleatum

uniprot E1BR00 159
type: UnificationXref
id: E1BR00
db: uniprot

uniprot Q9VC18 216
type: UnificationXref
id: Q9VC18
db: uniprot

PARTICIPANT STOICHIOMETRY r14 625
type: Stoichiometry
physical entity: GMP
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot Q8RH17 456
organism: Fusobacterium nucleatum

uniprot Q9U915 339
type: UnificationXref
id: Q9U915
db: uniprot

ncbitaxon 6239 77
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q8TD84 541
type: UnificationXref
id: Q8TD84
db: uniprot

Phosphoribosylamine glycine ligase
type: ProteinReference
xref: P02908
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.Phosphoribosylamine_br_glycine ligase
comment: ENTITY_REFERENCE_NOTES=Long Name: Phosphoribosylamine glycine ligase Synonym: Synonym not specified Accession: P02908
member entity reference: Trifunctional purine biosynthetic protein adenosine-3
member entity reference: Phosphoribosylamine--glycine ligase
member entity reference: Phosphoribosylglycinamide formyltransferase
member entity reference: Phosphoribosylamine--glycine ligase, chloroplastic
member entity reference: Bifunctional purine biosynthetic protein ADE5,7
member entity reference: Bifunctional purine biosynthetic protein ADE1

uniprot P38625 360
type: UnificationXref
id: P38625
db: uniprot

uniprot P49740 44
type: UnificationXref
id: P49740
db: uniprot

Adenylosuccinate synthetase isozyme 1
type: ProteinReference
xref: PTHR11846:SF2
xref: uniprot A5PJR4 86
organism: Bos taurus

Inosine-5'-monophosphate dehydrogenase 2
type: ProteinReference
xref: uniprot P24547 238
organism: Mus musculus

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q58661 61
organism: Methanocaldococcus jannaschii

uniprot P58793 101
type: UnificationXref
id: P58793
db: uniprot

IMP cyclohydrolase
type: ProteinReference
xref: P02894
comment: ENTITY_REFERENCE_NOTES=Long Name: IMP cyclohydrolase Synonym: Synonym not specified Accession: P02894
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.IMP cyclohydrolase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Bifunctional purine biosynthesis protein PURH
member entity reference: Phosphoribosylaminoimidazolecarboxamide formyltransferase
member entity reference: Bifunctional purine biosynthesis protein PurH
member entity reference: AICARFT/IMPCHase bienzyme family protein
member entity reference: Protein CBG17698
member entity reference: Bifunctional purine biosynthesis protein ADE16
member entity reference: Bifunctional purine biosynthesis protein ade10
member entity reference: Bifunctional purine biosynthesis protein ADE17
member entity reference: AGAP001423-PA
member entity reference: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
member entity reference: Phosphoribosylaminoimidazole-succinocarboxamide formyltransferase
member entity reference: RE29555p
member entity reference: Bifunctional purine biosynthesis protein purH
member entity reference: 5-Aminoimidazole-4-carboxamide ribonucleotide formylTransferase/IMP Cyclohydrolase homolog
member entity reference: Uncharacterized protein

uniprot Q384N4 445
type: UnificationXref
id: Q384N4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glycine-_5_phosphoribosylamine-_ATP-RIGHT__PO4-_ADP-_5_phosphoribosoyl_glycineamide-_r2
controller: Phosphoribosylamine glycine ligase

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 66

Amidophosphoribosyl transferase
type: Protein
entity reference: Amidophosphoribosyl transferase
comment: SPECIES_TYPE=PROTEIN

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q9X0I1 129
xref: PTHR11846:SF0
organism: Thermotoga maritima

uniprot Q58661 61
type: UnificationXref
id: Q58661
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q9X0I0 184
organism: Thermotoga maritima

Amidophosphoribosyl transferase
type: ProteinReference
xref: P02905
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Amidophosphoribosyl transferase Synonym: Synonym not specified Accession: P02905
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.Amidophosphoribosyl transferase
member entity reference: Amidophosphoribosyltransferase
member entity reference: Amidophosphoribosyltransferase 3, chloroplastic
member entity reference: Amidophosphoribosyltransferase (PurF)
member entity reference: Amidophosphoribosyltransferase 2, chloroplastic
member entity reference: Amidophosphoribosyltransferase 1, chloroplastic

Uncharacterized protein
type: ProteinReference
xref: uniprot H2Q705 15
organism: Pan troglodytes

uniprot Q9VEP6 183
type: UnificationXref
id: Q9VEP6
db: uniprot

PARTICIPANT STOICHIOMETRY r5 641
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 642
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot P91425 481
type: UnificationXref
id: P91425
db: uniprot

xanthosine-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r5 640
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

uniprot Q8RGI2 187
type: UnificationXref
id: Q8RGI2
db: uniprot

PARTICIPANT STOICHIOMETRY r5 644
type: Stoichiometry
physical entity: N5-carboxyamino imidazol ribonucleotide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 643
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

Phosphoribosylamine glycine ligase
type: Protein
entity reference: Phosphoribosylamine glycine ligase
comment: SPECIES_TYPE=PROTEIN

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot A8WS68 6
organism: Caenorhabditis briggsae

GH06691p
type: ProteinReference
xref: uniprot Q9VTB3 494
organism: Drosophila melanogaster

uniprot O75414 143
type: UnificationXref
id: O75414
db: uniprot

uniprot P73302 305
type: UnificationXref
id: P73302
db: uniprot

Ribonucleoside-diphosphate reductase subunit alpha
type: ProteinReference
xref: uniprot O66503 405
organism: Aquifex aeolicus

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot P74384 168
organism: Synechocystis

uniprot Q9U1D3 338
type: UnificationXref
id: Q9U1D3
db: uniprot

uniprot E2RF42 497
type: UnificationXref
id: E2RF42
db: uniprot

Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
type: ProteinReference
xref: uniprot O49203 22
organism: Arabidopsis thaliana

Inosine-5'-monophosphate dehydrogenase 2
type: ProteinReference
xref: uniprot B0UXP9 223
organism: Danio rerio

Inosine-5'-monophosphate dehydrogenase 2
type: ProteinReference
xref: uniprot Q3SWY3 247
organism: Bos taurus

uniprot P9WHQ7 508
type: UnificationXref
id: P9WHQ7
db: uniprot

uniprot Q8ZTP7 459
type: UnificationXref
id: Q8ZTP7
db: uniprot

Inosine-5'-monophosphate dehydrogenase (Fragment)
type: ProteinReference
xref: uniprot Q7QHD0 254
organism: Anopheles gambiae

Adenylosuccinate synthetase isozyme 1
type: ProteinReference
xref: PTHR11846:SF2
xref: uniprot Q8N142 119
organism: Homo sapiens

Adenylosuccinate synthetase 1, chloroplastic
type: ProteinReference
xref: uniprot Q10R17 108
xref: PTHR11846:SF0
organism: Oryza sativa

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot Q58347 559
organism: Methanocaldococcus jannaschii

PARTICIPANT STOICHIOMETRY r5 639
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 609
type: Stoichiometry
physical entity: GMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 638
type: Stoichiometry
physical entity: 5-phosphoribosyl-5-aminoimidazole
stoichiometric coefficient: 1.0

Adenylate kinase 4, mitochondrial
type: ProteinReference
xref: uniprot Q0VCP1 310
organism: Bos taurus

STATE_TRANSITION_LEFT__GDP-_ATP-RIGHT__ADP-_GTP-_r16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 604
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 602
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 605
participant stoichiometry: PARTICIPANT STOICHIOMETRY r16 603
left: ATP
left: GDP
interaction type: STATE_TRANSITION
right: ADP
right: GTP

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot Q382Q1 442
organism: Trypanosoma brucei

Down syndrome cell adhesion molecule-like protein 1
type: ProteinReference
xref: uniprot Q8TD84 541
organism: Homo sapiens

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot Q382Q0 441
organism: Trypanosoma brucei

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot Q382Q3 444
organism: Trypanosoma brucei

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot Q382Q2 443
organism: Trypanosoma brucei

Adenylate kinase
type: ProteinReference
xref: uniprot P43414 301
organism: Streptomyces coelicolor

Adenylate kinase 5, chloroplastic
type: ProteinReference
xref: uniprot Q8VYL1 329
organism: Arabidopsis thaliana

Nucleoside diphosphate kinase 7
type: ProteinReference
xref: uniprot H9FTL1 141
organism: Macaca mulatta

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: uniprot P21872 553
organism: Gallus gallus

uniprot Q0VCP1 310
type: UnificationXref
id: Q0VCP1
db: uniprot

uniprot O67475 406
type: UnificationXref
id: O67475
db: uniprot

uniprot P56597 145
type: UnificationXref
id: P56597
db: uniprot

Nucleoside diphosphate kinase A
type: ProteinReference
xref: uniprot Q05982 55
organism: Rattus norvegicus

ncbitaxon 13616 92
type: UnificationXref
id: 13616
db: ncbitaxon

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8RDR4 371
type: UnificationXref
id: Q8RDR4
db: uniprot

uniprot P00497 503
type: UnificationXref
id: P00497
db: uniprot

uniprot P34346 300
type: UnificationXref
id: P34346
db: uniprot

N5-carboxyaminoimidazole ribonucleotide synthase
type: ProteinReference
xref: P02906
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.N5-carboxyaminoimidazole_br_ribonucleotide synthase
comment: ENTITY_REFERENCE_NOTES=Long Name: N5-carboxyaminoimidazole ribonucleotide synthase Synonym: Synonym not specified Accession: P02906
member entity reference: Phosphoribosylaminoimidazole carboxylase
member entity reference: N5-carboxyaminoimidazole ribonucleotide mutase

uniprot P49723 426
type: UnificationXref
id: P49723
db: uniprot

AMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Nucleoside diphosphate kinase B
type: ProteinReference
xref: uniprot P19804 34
organism: Rattus norvegicus

5-Aminoimidazole-4-carboxamide ribonucleotide formylTransferase/IMP Cyclohydrolase homolog
type: ProteinReference
xref: uniprot Q95QQ4 210
organism: Caenorhabditis elegans

Trifunctional purine biosynthetic protein adenosine-3
type: ProteinReference
xref: uniprot F7GSL0 545
organism: Macaca mulatta

uniprot P50095 242
type: UnificationXref
id: P50095
db: uniprot

Bifunctional purine biosynthesis protein PurH
type: ProteinReference
xref: uniprot P74741 202
organism: Synechocystis

Adenylosuccinate synthetase isozyme 2
type: ProteinReference
xref: uniprot P46664 100
xref: PTHR11846:SF13
organism: Mus musculus

uniprot E2REX1 277
type: UnificationXref
id: E2REX1
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q9RRJ1 152
organism: Deinococcus radiodurans

PARTICIPANT STOICHIOMETRY r15 612
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r15 611
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase 1 subunit beta
type: ProteinReference
xref: uniprot P69924 430
organism: Escherichia coli

PARTICIPANT STOICHIOMETRY r15 610
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Anaerobic ribonucleoside-triphosphate reductase
type: ProteinReference
xref: uniprot Q8A688 185
organism: Bacteroides thetaiotaomicron

ATP reductase
type: ProteinReference
xref: P02893
comment: ENTITY_REFERENCE_NOTES=Long Name: ATP reductase Synonym: Synonym not specified Accession: P02893
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.ATP reductase
member entity reference: Anaerobic ribonucleoside-triphosphate reductase

uniprot G4FH33 401
type: UnificationXref
id: G4FH33
db: uniprot

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9RXT6 525
organism: Deinococcus radiodurans

PARTICIPANT STOICHIOMETRY r2 660
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

Adenylate kinase isoenzyme 1
type: ProteinReference
xref: uniprot A0A2I3T5C3 266
organism: Pan troglodytes

uniprot A2FQ69 269
type: UnificationXref
id: A2FQ69
db: uniprot

PARTICIPANT STOICHIOMETRY r2 661
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 662
type: Stoichiometry
physical entity: 5-phosphoribosoyl glycineamide
stoichiometric coefficient: 1.0

Adenylate kinase
type: ProteinReference
xref: uniprot P34346 300
organism: Caenorhabditis elegans

AGAP009660-PA
type: ProteinReference
xref: uniprot Q7Q1R6 320
organism: Anopheles gambiae

Ribonucleoside-diphosphate reductase subunit alpha
type: ProteinReference
xref: uniprot P9WH75 437
organism: Mycobacterium tuberculosis

Vitamin B12-dependent ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot P9WH77 438
organism: Mycobacterium tuberculosis

Bifunctional purine biosynthesis protein PURH
type: ProteinReference
xref: uniprot P31939 199
organism: Homo sapiens

uniprot P79733 434
type: UnificationXref
id: P79733
db: uniprot

Adenylate kinase
type: ProteinReference
xref: uniprot Q9U915 339
organism: Drosophila melanogaster

Adenylosuccinate lyase (PurB)
type: ProteinReference
xref: uniprot Q8ZY28 178
organism: Pyrobaculum aerophilum

Adenylate kinase isoenzyme 5
type: ProteinReference
xref: uniprot Q9Y6K8 348
organism: Homo sapiens

uniprot Q02787 107
type: UnificationXref
id: Q02787
db: uniprot

Ribonucleoside-diphosphate reductase subunit beta nrdF2
type: ProteinReference
xref: uniprot P9WH71 435
organism: Mycobacterium tuberculosis

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: uniprot P31350 417
organism: Homo sapiens

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot F6TWB9 8
organism: Ornithorhynchus anatinus

Ribonucleoside-diphosphate reductase subunit beta nrdF1
type: ProteinReference
xref: uniprot P9WH73 436
organism: Mycobacterium tuberculosis

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q8ZY26 122
xref: PTHR11846:SF0
organism: Pyrobaculum aerophilum

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q8IDF6 117
xref: PTHR11846:SF0
organism: Plasmodium falciparum

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q57981 110
xref: PTHR11846:SF0
organism: Methanocaldococcus jannaschii

uniprot O66601 356
type: UnificationXref
id: O66601
db: uniprot

uniprot D3ZH90 135
type: UnificationXref
id: D3ZH90
db: uniprot

uniprot Q9FK35 332
type: UnificationXref
id: Q9FK35
db: uniprot

STATE_TRANSITION_LEFT__ATP-_dADP-RIGHT__ADP-_dATP-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 674
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 673
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 675
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 676
left: ATP
left: dADP
interaction type: STATE_TRANSITION
right: dATP
right: ADP

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot O66949 547
organism: Aquifex aeolicus

uniprot Q9HQM6 125
type: UnificationXref
id: Q9HQM6
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot G3V816 13
organism: Rattus norvegicus

Phosphoribosylglycinamide formyltransferase
type: ProteinReference
xref: uniprot Q9I514 569
organism: Pseudomonas aeruginosa

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot P07742 411
organism: Mus musculus

uniprot Q84JF7 322
type: UnificationXref
id: Q84JF7
db: uniprot

uniprot P80210 104
type: UnificationXref
id: P80210
db: uniprot

uniprot Q8GUN7 174
type: UnificationXref
id: Q8GUN7
db: uniprot

uniprot Q9SJ20 472
type: UnificationXref
id: Q9SJ20
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 5

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot Q9HUV8 568
organism: Pseudomonas aeruginosa

uniprot F7GPV9 500
type: UnificationXref
id: F7GPV9
db: uniprot

10-formyl-THF
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Bifunctional purine biosynthesis protein PurH
type: ProteinReference
xref: uniprot Q9HUV9 213
organism: Pseudomonas aeruginosa

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot Q9C167 460
organism: Neurospora crassa

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P08879 29
organism: Drosophila melanogaster

Bifunctional purine biosynthesis protein PURH
type: ProteinReference
xref: uniprot P31335 198
organism: Gallus gallus

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 9

Protein CBG17698
type: ProteinReference
xref: uniprot A8XRH8 189
organism: Caenorhabditis briggsae

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot A8XST9 496
organism: Caenorhabditis briggsae

uniprot Q8TKT6 563
type: UnificationXref
id: Q8TKT6
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q8TFN0 72
organism: Emericella nidulans

Phosphoribosylaminoimidazole carboxylase
type: ProteinReference
xref: uniprot Q8TR08 535
organism: Methanosarcina acetivorans

Uncharacterized protein
type: ProteinReference
xref: uniprot Q19599 440
organism: Caenorhabditis elegans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_Red_FlR-RIGHT__dGTP-_Ox_FlR-_r18
controller: GTP reductase

Probable UMP-CMP kinase 2
type: ProteinReference
xref: uniprot Q6NMK6 319
organism: Arabidopsis thaliana

uniprot Q55621 513
type: UnificationXref
id: Q55621
db: uniprot

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot E2R8P1 393
organism: Canis lupus familiaris

uniprot Q8LAH8 71
type: UnificationXref
id: Q8LAH8
db: uniprot

uniprot Q8TQL6 74
type: UnificationXref
id: Q8TQL6
db: uniprot

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q7QEW3 516
organism: Anopheles gambiae

uniprot P46664 100
type: UnificationXref
id: P46664
db: uniprot

uniprot Q4QD53 248
type: UnificationXref
id: Q4QD53
db: uniprot

uniprot F6YCP3 281
type: UnificationXref
id: F6YCP3
db: uniprot

uniprot Q9X0X7 572
type: UnificationXref
id: Q9X0X7
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q9VEP6 183
organism: Drosophila melanogaster

THF
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q32M07 313
type: UnificationXref
id: Q32M07
db: uniprot

uniprot A7MBG0 87
type: UnificationXref
id: A7MBG0
db: uniprot

uniprot Q9RSK7 337
type: UnificationXref
id: Q9RSK7
db: uniprot

uniprot Q8REV0 534
type: UnificationXref
id: Q8REV0
db: uniprot

Nucleoside diphosphate kinase 1
type: ProteinReference
xref: uniprot Q07661 56
organism: Oryza sativa

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P9WJH7 52
organism: Mycobacterium tuberculosis

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q8TQL6 74
organism: Methanosarcina acetivorans

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q9RZL7 471
organism: Deinococcus radiodurans

Adenylate kinase 3
type: ProteinReference
xref: uniprot Q9FK35 332
organism: Arabidopsis thaliana

Ribonucleoside-diphosphate reductase, beta chain
type: ProteinReference
xref: uniprot Q9RZL6 470
organism: Deinococcus radiodurans

GTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Bifunctional purine biosynthesis protein PURH
type: ProteinReference
xref: uniprot Q9CWJ9 211
organism: Mus musculus

NADH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Bifunctional purine biosynthetic protein ADE1
type: ProteinReference
xref: uniprot P20772 552
organism: Schizosaccharomyces pombe

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot P0AB89 163
organism: Escherichia coli

STATE_TRANSITION_LEFT__ADP-_RSH-RIGHT__H2O-_dADP-_RS_SR-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 677
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 678
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 680
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 679
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 681
left: RSH
left: ADP
interaction type: STATE_TRANSITION
right: dADP
right: H2O
right: RS-SR

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot Q8ZTP7 459
organism: Pyrobaculum aerophilum

uniprot P15531 31
type: UnificationXref
id: P15531
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot O67820 234
organism: Aquifex aeolicus

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 18

Bifunctional purine biosynthesis protein PURH
type: ProteinReference
xref: uniprot Q0VCK0 204
organism: Bos taurus

uniprot P9WHM7 203
type: UnificationXref
id: P9WHM7
db: uniprot

PARTICIPANT STOICHIOMETRY r9 598
type: Stoichiometry
physical entity: 5-phosphoribosyl-5-amino-4-imidazole
stoichiometric coefficient: 1.0

uniprot Q86A85 517
type: UnificationXref
id: Q86A85
db: uniprot

Ribonucleotide reductase regulatory TP53 inducible subunit M2B
type: ProteinReference
xref: uniprot A0A2I3SX17 386
organism: Pan troglodytes

uniprot P37146 420
type: UnificationXref
id: P37146
db: uniprot

uniprot Q9HS43 212
type: UnificationXref
id: Q9HS43
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GDP-_ATP-RIGHT__ADP-_GTP-_r16
controller: GDP kinase

uniprot D3ZLZ7 224
type: UnificationXref
id: D3ZLZ7
db: uniprot

PARTICIPANT STOICHIOMETRY r9 599
type: Stoichiometry
physical entity: 10-formyl-THF
stoichiometric coefficient: 1.0

uniprot P39452 421
type: UnificationXref
id: P39452
db: uniprot

Bifunctional purine biosynthesis protein PurH
type: ProteinReference
xref: uniprot Q9RW01 215
organism: Deinococcus radiodurans

uniprot O88425 144
type: UnificationXref
id: O88425
db: uniprot

uniprot E2R7H9 392
type: UnificationXref
id: E2R7H9
db: uniprot

uniprot Q7QBZ6 173
type: UnificationXref
id: Q7QBZ6
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 115

Inosine-5'-monophosphate dehydrogenase 1
type: ProteinReference
xref: uniprot P50096 243
organism: Mus musculus

Inosine-5'-monophosphate dehydrogenase 3
type: ProteinReference
xref: uniprot P50095 242
organism: Saccharomyces cerevisiae

Inosine-5'-monophosphate dehydrogenase 4
type: ProteinReference
xref: uniprot P50094 241
organism: Saccharomyces cerevisiae

uniprot Q8TJ18 177
type: UnificationXref
id: Q8TJ18
db: uniprot

uniprot E2R8P1 393
type: UnificationXref
id: E2R8P1
db: uniprot

Ribonucleoside-diphosphate reductase large chain
type: ProteinReference
xref: uniprot Q9UW15 473
organism: Neurospora crassa

uniprot P39207 43
type: UnificationXref
id: P39207
db: uniprot

5-phosphoribosoyl glycineamide
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot R9PXW5 155
type: UnificationXref
id: R9PXW5
db: uniprot

dGDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8ZY26 122
type: UnificationXref
id: Q8ZY26
db: uniprot

uniprot Q20143 558
type: UnificationXref
id: Q20143
db: uniprot

uniprot Q4QC71 316
type: UnificationXref
id: Q4QC71
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot D3ZW08 158
organism: Rattus norvegicus

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q9HQM6 125
xref: PTHR11846:SF0
organism: Halobacterium salinarum

uniprot P21672 415
type: UnificationXref
id: P21672
db: uniprot

Ribonucleoside-diphosphate reductase small subunit
type: ProteinReference
xref: uniprot P42521 423
organism: Dictyostelium discoideum

PARTICIPANT STOICHIOMETRY r24 676
type: Stoichiometry
physical entity: dATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 675
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r24 674
type: Stoichiometry
physical entity: dADP
stoichiometric coefficient: 1.0

uniprot P74384 168
type: UnificationXref
id: P74384
db: uniprot

PARTICIPANT STOICHIOMETRY r24 673
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

NME/NM23 family member 7
type: ProteinReference
xref: uniprot A0A2I3RRZ0 133
organism: Pan troglodytes

Adenylate kinase 8
type: ProteinReference
xref: uniprot H2QY34 285
organism: Pan troglodytes

uniprot Q9RT87 262
type: UnificationXref
id: Q9RT87
db: uniprot

uniprot H2QRJ9 140
type: UnificationXref
id: H2QRJ9
db: uniprot

uniprot Q9I4I1 465
type: UnificationXref
id: Q9I4I1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-_Aspartate-_IMP-RIGHT__PO4-_GDP-_adenylo_succinate-_r20
controller: Adenylosuccinate synthase

PARTICIPANT STOICHIOMETRY r6 627
type: Stoichiometry
physical entity: N5-carboxyamino imidazol ribonucleotide
stoichiometric coefficient: 1.0

GTP:AMP phosphotransferase, mitochondrial
type: ProteinReference
xref: uniprot Q9VGU6 341
organism: Drosophila melanogaster

Adenylate kinase 2, mitochondrial
type: ProteinReference
xref: uniprot A0A2I3SVF7 265
organism: Pan troglodytes

Red FlR
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RRW1 469
type: UnificationXref
id: Q9RRW1
db: uniprot

PARTICIPANT STOICHIOMETRY r6 628
type: Stoichiometry
physical entity: phosphoribosyl carboxy aminoimidazole
stoichiometric coefficient: 1.0

ncbitaxon 224308 39
type: UnificationXref
id: 224308
db: ncbitaxon

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9HXM5 259
type: UnificationXref
id: Q9HXM5
db: uniprot

uniprot Q9HY93 384
type: UnificationXref
id: Q9HY93
db: uniprot

N5-carboxyaminoimidazole ribonucleotide mutase
type: ProteinReference
xref: uniprot O67239 530
organism: Aquifex aeolicus

ATP reductase
type: Protein
entity reference: ATP reductase
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2J8PA11 134
type: UnificationXref
id: A0A2J8PA11
db: uniprot

Adenylate kinase 4, mitochondrial
type: ProteinReference
xref: uniprot H2PZ67 284
organism: Pan troglodytes

uniprot P46195 478
type: UnificationXref
id: P46195
db: uniprot

AICAR transformylase
type: Protein
entity reference: AICAR transformylase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9X0I0 184
type: UnificationXref
id: Q9X0I0
db: uniprot

uniprot A0A2I3RRZ0 133
type: UnificationXref
id: A0A2I3RRZ0
db: uniprot

Guanylate kinase
type: ProteinReference
xref: uniprot P15454 477
organism: Saccharomyces cerevisiae

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot A0A2I3TM38 220
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YCP3 281
organism: Macaca mulatta

uniprot Q99148 565
type: UnificationXref
id: Q99148
db: uniprot

Adenylate kinase isoenzyme 1
type: ProteinReference
xref: uniprot A0A2R8RXT8 267
organism: Danio rerio

AK5 isoform 1
type: ProteinReference
xref: uniprot H2R2P9 286
organism: Pan troglodytes

uniprot Q05911 169
type: UnificationXref
id: Q05911
db: uniprot

PARTICIPANT STOICHIOMETRY r17 596
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r17 597
type: Stoichiometry
physical entity: RSSR
stoichiometric coefficient: 1.0

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot G4FH33 401
organism: Thermotoga maritima

Adenylosuccinate synthetase, chloroplastic
type: ProteinReference
xref: uniprot Q96529 124
xref: PTHR11846:SF0
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r17 594
type: Stoichiometry
physical entity: RSH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r17 595
type: Stoichiometry
physical entity: dGDP
stoichiometric coefficient: 1.0

uniprot E2RH37 278
type: UnificationXref
id: E2RH37
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot E1BR00 159
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r17 593
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot A0A0R4IS05 2
organism: Danio rerio

Guanylate kinase
type: ProteinReference
xref: uniprot Q9RS38 493
organism: Deinococcus radiodurans

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot Q9SJ20 472
organism: Arabidopsis thaliana

uniprot P9WH77 438
type: UnificationXref
id: P9WH77
db: uniprot

PARTICIPANT STOICHIOMETRY r2 659
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Phosphoribosylformylglycinamide synthase
type: Protein
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r2 657
type: Stoichiometry
physical entity: glycine
stoichiometric coefficient: 1.0

uniprot Q9WV85 82
type: UnificationXref
id: Q9WV85
db: uniprot

PARTICIPANT STOICHIOMETRY r2 658
type: Stoichiometry
physical entity: 5-phosphoribosylamine
stoichiometric coefficient: 1.0

uniprot A0A3Q1MKM8 268
type: UnificationXref
id: A0A3Q1MKM8
db: uniprot

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot O67236 502
organism: Aquifex aeolicus

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 57

uniprot Q8A688 185
type: UnificationXref
id: Q8A688
db: uniprot

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 64

uniprot F6TKJ2 396
type: UnificationXref
id: F6TKJ2
db: uniprot

uniprot Q9C167 460
type: UnificationXref
id: Q9C167
db: uniprot

Inosine-5'-monophosphate dehydrogenase 1
type: ProteinReference
xref: uniprot P47996 240
organism: Arabidopsis thaliana

uniprot O84835 409
type: UnificationXref
id: O84835
db: uniprot

uniprot E9PU28 225
type: UnificationXref
id: E9PU28
db: uniprot

STATE_TRANSITION_LEFT__5_phosphoribosyl_N_formyl_glycineamide-_ATP-RIGHT__PO4-_ADP-_5_phosphoribosyl_5_aminoimidazole-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 650
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 647
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 651
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 649
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 648
left: ATP
left: 5-phosphoribosyl N-formyl glycineamide
interaction type: STATE_TRANSITION
right: PO4
right: 5-phosphoribosyl-5-aminoimidazole
right: ADP

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__5_phosphoribosyl_5_amino_4_imidazole-_10_formyl_THF-RIGHT__phosphoribosyl_formamido_carboxamide-_THF-_r9
controller: AICAR transformylase

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q59Q46 250
organism: Candida albicans

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 49

uniprot A0A1D5QK39 264
type: UnificationXref
id: A0A1D5QK39
db: uniprot

Guanylate kinase 3, chloroplastic
type: ProteinReference
xref: uniprot Q94JM2 488
organism: Arabidopsis thaliana

uniprot G3V816 13
type: UnificationXref
id: G3V816
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q93576 76
organism: Caenorhabditis elegans

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q7QDK6 116
xref: PTHR11846:SF0
organism: Anopheles gambiae

uniprot Q9RW01 215
type: UnificationXref
id: Q9RW01
db: uniprot

phosphoribosyl-formamido-carboxamide
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 68

STATE_TRANSITION_LEFT__N5_carboxyamino_imidazol_ribonucleotide-RIGHT__phosphoribosyl_carboxy_aminoimidazole-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 627
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 628
left: N5-carboxyamino imidazol ribonucleotide
interaction type: STATE_TRANSITION
right: phosphoribosyl carboxy aminoimidazole

Nucleoside diphosphate kinase 6
type: ProteinReference
xref: uniprot O75414 143
organism: Homo sapiens

uniprot P09938 412
type: UnificationXref
id: P09938
db: uniprot

ncbitaxon 224324 26
type: UnificationXref
id: 224324
db: ncbitaxon

uniprot A0A0R4IS05 2
type: UnificationXref
id: A0A0R4IS05
db: uniprot

uniprot A8WS68 6
type: UnificationXref
id: A8WS68
db: uniprot

uniprot Q7KWJ4 172
type: UnificationXref
id: Q7KWJ4
db: uniprot

uniprot P16304 294
type: UnificationXref
id: P16304
db: uniprot

Guanylate kinase 1
type: ProteinReference
xref: uniprot E9PTV0 474
organism: Rattus norvegicus

By Homology
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r1 664
type: Stoichiometry
physical entity: PRPP
stoichiometric coefficient: 1.0

5-phosphoribosyl-5-aminoimidazole
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P9WHN3 106
type: UnificationXref
id: P9WHN3
db: uniprot

PARTICIPANT STOICHIOMETRY r1 663
type: Stoichiometry
physical entity: glutamine
stoichiometric coefficient: 1.0

5-phosphoribosyl-5-amino-4-imidazole
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r1 666
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 665
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Inosine-5'-monophosphate dehydrogenase 2
type: ProteinReference
xref: uniprot P38697 239
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r1 668
type: Stoichiometry
physical entity: 5-phosphoribosylamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 667
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

ncbitaxon 83333 164
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot Q8VY84 328
type: UnificationXref
id: Q8VY84
db: uniprot

uniprot Q9HQ67 567
type: UnificationXref
id: Q9HQ67
db: uniprot

Nucleoside diphosphate kinase 6
type: ProteinReference
xref: uniprot Q6DI51 147
organism: Danio rerio

Aspartate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Nucleoside diphosphate kinase 7
type: ProteinReference
xref: uniprot Q9Y5B8 154
organism: Homo sapiens

Adenylate kinase 1, chloroplastic
type: ProteinReference
xref: uniprot Q9ZUU1 349
organism: Arabidopsis thaliana

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 51

GUanylate Kinase
type: ProteinReference
xref: uniprot P91425 481
organism: Caenorhabditis elegans

ADP reductase
type: Protein
entity reference: ADP reductase
comment: SPECIES_TYPE=PROTEIN

uniprot Q07661 56
type: UnificationXref
id: Q07661
db: uniprot

ncbitaxon 8364 66
type: UnificationXref
id: 8364
db: ncbitaxon

Adenylate kinase 2
type: ProteinReference
xref: uniprot Q4Q3J6 315
organism: Leishmania major

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot P9WHQ7 508
organism: Mycobacterium tuberculosis

uniprot Q9UW15 473
type: UnificationXref
id: Q9UW15
db: uniprot

uniprot F7GGT3 400
type: UnificationXref
id: F7GGT3
db: uniprot

uniprot O67239 530
type: UnificationXref
id: O67239
db: uniprot

uniprot F7BUU3 93
type: UnificationXref
id: F7BUU3
db: uniprot

ncbitaxon 9606 21
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q9X8P6 131
type: UnificationXref
id: Q9X8P6
db: uniprot

uniprot Q9ZUU1 349
type: UnificationXref
id: Q9ZUU1
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot F6VXT4 228
organism: Macaca mulatta

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot F1MCI2 137
organism: Bos taurus

uniprot P22887 36
type: UnificationXref
id: P22887
db: uniprot

uniprot Q7QIF4 453
type: UnificationXref
id: Q7QIF4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NAQ8 352
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r8 607
type: Stoichiometry
physical entity: fumarate
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PEK4 538
organism: Canis lupus familiaris

uniprot Q5ZJL5 114
type: UnificationXref
id: Q5ZJL5
db: uniprot

Nucleoside diphosphate kinase A
type: ProteinReference
xref: uniprot P15532 32
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r8 606
type: Stoichiometry
physical entity: 5-phosphoribosyl-4-(N-succino-carboxyamide)-5-aminoimidazol
stoichiometric coefficient: 1.0

Nucleoside diphosphate kinase A
type: ProteinReference
xref: uniprot P15531 31
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r8 608
type: Stoichiometry
physical entity: 5-phosphoribosyl-5-amino-4-imidazole
stoichiometric coefficient: 1.0

uniprot Q9RZL7 471
type: UnificationXref
id: Q9RZL7
db: uniprot

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 186

Adenylosuccinate synthetase isozyme 2
type: ProteinReference
xref: uniprot A0A1D5Q943 83
xref: PTHR11846:SF13
organism: Macaca mulatta

uniprot Q22134 510
type: UnificationXref
id: Q22134
db: uniprot

PTHR11846:SF13
type: RelationshipXref
id: PTHR11846:SF13
db: PANTHER Family
relationship type: By Homology

uniprot O84033 476
type: UnificationXref
id: O84033
db: uniprot

uniprot Q7QDK6 116
type: UnificationXref
id: Q7QDK6
db: uniprot

5-phosphoribosyl-4-(N-succino-carboxyamide)-5-aminoimidazol
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O64903 24
type: UnificationXref
id: O64903
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 45

uniprot P21872 553
type: UnificationXref
id: P21872
db: uniprot

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
type: ProteinReference
xref: uniprot H2R0X5 192
organism: Pan troglodytes

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot E1C4Q0 391
organism: Gallus gallus

uniprot Q21774 170
type: UnificationXref
id: Q21774
db: uniprot

uniprot P29411 298
type: UnificationXref
id: P29411
db: uniprot

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot F1P3I8 499
organism: Gallus gallus

uniprot P47996 240
type: UnificationXref
id: P47996
db: uniprot

Guanine monophosphate synthase
type: ProteinReference
xref: uniprot H2QNM5 355
organism: Pan troglodytes

uniprot F1MCI2 137
type: UnificationXref
id: F1MCI2
db: uniprot

ncbitaxon 178306 123
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot Q9X215 495
type: UnificationXref
id: Q9X215
db: uniprot

uniprot F7HA84 12
type: UnificationXref
id: F7HA84
db: uniprot

ncbitaxon 559292 42
type: UnificationXref
id: 559292
db: ncbitaxon

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q3THK7 364
organism: Mus musculus

uniprot Q8TIX7 209
type: UnificationXref
id: Q8TIX7
db: uniprot

uniprot Q9RYC7 536
type: UnificationXref
id: Q9RYC7
db: uniprot

uniprot A0A2I3TVQ6 156
type: UnificationXref
id: A0A2I3TVQ6
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q9HS42 179
organism: Halobacterium salinarum

Phosphoribosylaminoimidazole-succinocarboxamide formyltransferase
type: ProteinReference
xref: uniprot Q9HS43 212
organism: Halobacterium salinarum

uniprot P12047 165
type: UnificationXref
id: P12047
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9RT87 262
organism: Deinococcus radiodurans

Probable adenylate kinase isoenzyme ZK673.2
type: ProteinReference
xref: uniprot Q09629 309
organism: Caenorhabditis elegans

uniprot P20772 552
type: UnificationXref
id: P20772
db: uniprot

uniprot P29727 358
type: UnificationXref
id: P29727
db: uniprot

AGAP011105-PA
type: ProteinReference
xref: uniprot Q7PSP6 486
organism: Anopheles gambiae

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot F6U4A0 397
organism: Ornithorhynchus anatinus

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot H2R178 232
organism: Pan troglodytes

uniprot A0A2I3SVF7 265
type: UnificationXref
id: A0A2I3SVF7
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q9VY27 153
organism: Drosophila melanogaster

Adenylate kinase
type: ProteinReference
xref: uniprot Q9HE76 333
organism: Neurospora crassa

uniprot P74232 556
type: UnificationXref
id: P74232
db: uniprot

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9HPS4 524
organism: Halobacterium salinarum

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 21

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q9RT91 381
organism: Deinococcus radiodurans

PARTICIPANT STOICHIOMETRY r22 573
type: Stoichiometry
physical entity: AMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 575
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r22 574
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P31103 38
organism: Bacillus subtilis

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot F7CDE0 10
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__5_phosphoribosyl_4__N_succino_carboxyamide__5_aminoimidazol-RIGHT__fumarate-_5_phosphoribosyl_5_amino_4_imidazole-_r8
controller: 5-Phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole lyase

GTP:AMP phosphotransferase
type: ProteinReference
xref: uniprot Q8I1T1 323
organism: Plasmodium falciparum

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q8RDR4 371
organism: Fusobacterium nucleatum

dGTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P34093 40
type: UnificationXref
id: P34093
db: uniprot

Adenylate kinase
type: ProteinReference
xref: uniprot Q8RE31 326
organism: Fusobacterium nucleatum

Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
type: ProteinReference
xref: uniprot Q8LAH8 71
organism: Arabidopsis thaliana

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot P00497 503
organism: Bacillus subtilis

dADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AMP-_ATP-RIGHT__ADP-_r22
controller: Adenylate kinase

uniprot Q6PEE3 451
type: UnificationXref
id: Q6PEE3
db: uniprot

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q55621 513
organism: Synechocystis

uniprot P50621 428
type: UnificationXref
id: P50621
db: uniprot

Adenylate kinase 8
type: ProteinReference
xref: uniprot Q96MA6 331
organism: Homo sapiens

Phosphoribosylglycinamide formyltransferase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q9RS38 493
type: UnificationXref
id: Q9RS38
db: uniprot

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot Q9X0X7 572
organism: Thermotoga maritima

uniprot F1PEK4 538
type: UnificationXref
id: F1PEK4
db: uniprot

STATE_TRANSITION_LEFT__glycine-_5_phosphoribosylamine-_ATP-RIGHT__PO4-_ADP-_5_phosphoribosoyl_glycineamide-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 657
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 658
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 661
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 660
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 659
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 662
left: glycine
left: ATP
left: 5-phosphoribosylamine
interaction type: STATE_TRANSITION
right: PO4
right: 5-phosphoribosoyl glycineamide
right: ADP

uniprot Q7LG56 452
type: UnificationXref
id: Q7LG56
db: uniprot

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9X0X4 529
organism: Thermotoga maritima

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Bifunctional purine biosynthesis protein PurH
type: ProteinReference
xref: uniprot Q9X0X6 217
organism: Thermotoga maritima

Guanylate kinase
type: ProteinReference
xref: uniprot P46195 478
organism: Bos taurus

SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot O30601 403
organism: Bacillus subtilis

dADP kinase
type: Protein
entity reference: dADP kinase
comment: SPECIES_TYPE=PROTEIN

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot P42170 422
organism: Caenorhabditis elegans

uniprot O49203 22
type: UnificationXref
id: O49203
db: uniprot

uniprot O30601 403
type: UnificationXref
id: O30601
db: uniprot

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot Q9HQ67 567
organism: Halobacterium salinarum

uniprot Q9U0T7 182
type: UnificationXref
id: Q9U0T7
db: uniprot

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O74928 195
type: UnificationXref
id: O74928
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q9UUY8 80
organism: Neurospora crassa

uniprot Q8THK3 373
type: UnificationXref
id: Q8THK3
db: uniprot

uniprot Q99MH5 149
type: UnificationXref
id: Q99MH5
db: uniprot

uniprot A0A1D5R3I3 219
type: UnificationXref
id: A0A1D5R3I3
db: uniprot

IMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot E1BI58 390
type: UnificationXref
id: E1BI58
db: uniprot

uniprot Q01768 54
type: UnificationXref
id: Q01768
db: uniprot

uniprot Q4V7C6 365
type: UnificationXref
id: Q4V7C6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MKM8 268
organism: Bos taurus

uniprot Q9VGU6 341
type: UnificationXref
id: Q9VGU6
db: uniprot

uniprot Q9X1I8 345
type: UnificationXref
id: Q9X1I8
db: uniprot

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9GZH3 257
type: UnificationXref
id: Q9GZH3
db: uniprot

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 102

uniprot B0UXP9 223
type: UnificationXref
id: B0UXP9
db: uniprot

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot Q5BEY7 111
xref: PTHR11846:SF0
organism: Emericella nidulans

Adenylate kinase, putative
type: ProteinReference
xref: uniprot Q38EC4 314
organism: Trypanosoma brucei

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 37

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ADP-_RSH-RIGHT__H2O-_dADP-_RS_SR-_r23
controller: ADP reductase

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q6AZK9 65
organism: Xenopus tropicalis

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot P36603 419
organism: Schizosaccharomyces pombe

Ribonucleoside-diphosphate reductase large chain
type: ProteinReference
xref: uniprot P36602 418
organism: Schizosaccharomyces pombe

Adenylate kinase isoenzyme 5 isoform 1
type: ProteinReference
xref: uniprot F6V935 280
organism: Macaca mulatta

uniprot P08179 549
type: UnificationXref
id: P08179
db: uniprot

Anaerobic ribonucleoside-triphosphate reductase
type: ProteinReference
xref: uniprot Q8RGI2 187
organism: Fusobacterium nucleatum

uniprot P28650 97
type: UnificationXref
id: P28650
db: uniprot

Guanylate kinase
type: ProteinReference
xref: uniprot Q9X215 495
organism: Thermotoga maritima

5-phosphoribosyl N-formyl glycineamide
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot P73290 103
xref: PTHR11846:SF0
organism: Synechocystis

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 60

Nucleoside diphosphate kinase homolog 5
type: ProteinReference
xref: uniprot P56597 145
organism: Homo sapiens

uniprot P31103 38
type: UnificationXref
id: P31103
db: uniprot

uniprot H2QNM5 355
type: UnificationXref
id: H2QNM5
db: uniprot

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot P41390 507
organism: Schizosaccharomyces pombe

Inosine-5'-monophosphate dehydrogenase 1b
type: ProteinReference
xref: uniprot Q5RGV1 252
organism: Danio rerio

Adenylate kinase 2, mitochondrial
type: ProteinReference
xref: uniprot Q9WTP6 342
organism: Mus musculus

uniprot A0A2I3T1L1 543
type: UnificationXref
id: A0A2I3T1L1
db: uniprot

GTP:AMP phosphotransferase AK3, mitochondrial
type: ProteinReference
xref: uniprot Q9WTP7 343
organism: Mus musculus

uniprot P9WKE9 483
type: UnificationXref
id: P9WKE9
db: uniprot

Nucleoside diphosphate kinase II, chloroplastic
type: ProteinReference
xref: uniprot O64903 24
organism: Arabidopsis thaliana

Adenylate kinase
type: ProteinReference
xref: uniprot A2FQ69 269
organism: Trichomonas vaginalis

Adenylate kinase
type: ProteinReference
xref: uniprot P33075 299
organism: Schizosaccharomyces pombe

uniprot O04905 287
type: UnificationXref
id: O04905
db: uniprot

Guanylate kinase
type: ProteinReference
xref: uniprot O34328 475
organism: Bacillus subtilis

uniprot Q57981 110
type: UnificationXref
id: Q57981
db: uniprot

uniprot P30520 99
type: UnificationXref
id: P30520
db: uniprot

uniprot Q9HT76 464
type: UnificationXref
id: Q9HT76
db: uniprot

uniprot Q8TPJ2 121
type: UnificationXref
id: Q8TPJ2
db: uniprot

uniprot F7CYY5 230
type: UnificationXref
id: F7CYY5
db: uniprot

GMP synthase [glutamine-hydrolyzing] subunit A
type: ProteinReference
xref: uniprot Q8THC7 372
organism: Methanosarcina acetivorans

uniprot Q9L0H2 379
type: UnificationXref
id: Q9L0H2
db: uniprot

N5-carboxyamino imidazol ribonucleotide
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

DS cell adhesion molecule-like 1
type: ProteinReference
xref: uniprot D3ZPL7 537
organism: Rattus norvegicus

Ribonucleoside-diphosphate reductase 1 subunit alpha
type: ProteinReference
xref: uniprot P00452 410
organism: Escherichia coli

uniprot A8X1T4 222
type: UnificationXref
id: A8X1T4
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot K7BSW8 19
organism: Pan troglodytes

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q381H3 59
organism: Trypanosoma brucei

STATE_TRANSITION_LEFT__Ox_FlR-_dATP-RIGHT__Red_FlR-_ATP-_r25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 672
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 670
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 671
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 669
left: dATP
left: Ox FlR
interaction type: STATE_TRANSITION
right: ATP
right: Red FlR

uniprot Q382Q2 443
type: UnificationXref
id: Q382Q2
db: uniprot

Inosine-5'-monophosphate dehydrogenase 2
type: ProteinReference
xref: uniprot E9PU28 225
organism: Rattus norvegicus

uniprot Q8ZZK4 564
type: UnificationXref
id: Q8ZZK4
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q9X168 263
organism: Thermotoga maritima

RS-SR
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q5TNU6 449
type: UnificationXref
id: Q5TNU6
db: uniprot

Amidophosphoribosyltransferase 2, chloroplastic
type: ProteinReference
xref: uniprot Q9STG9 527
organism: Arabidopsis thaliana

uniprot Q8TUJ5 188
type: UnificationXref
id: Q8TUJ5
db: uniprot

Adenylate kinase 2, mitochondrial
type: ProteinReference
xref: uniprot E2RE39 276
organism: Canis lupus familiaris

uniprot Q9HS42 179
type: UnificationXref
id: Q9HS42
db: uniprot

uniprot P35433 506
type: UnificationXref
id: P35433
db: uniprot

uniprot Q7AKK3 515
type: UnificationXref
id: Q7AKK3
db: uniprot

uniprot Q8RWT5 208
type: UnificationXref
id: Q8RWT5
db: uniprot

uniprot P72641 304
type: UnificationXref
id: P72641
db: uniprot

AGAP001423-PA
type: ProteinReference
xref: uniprot Q7PXI8 205
organism: Anopheles gambiae

uniprot C4M9S5 274
type: UnificationXref
id: C4M9S5
db: uniprot

uniprot A0JNA3 221
type: UnificationXref
id: A0JNA3
db: uniprot

uniprot Q64737 560
type: UnificationXref
id: Q64737
db: uniprot

uniprot O67820 234
type: UnificationXref
id: O67820
db: uniprot

uniprot F6SL91 395
type: UnificationXref
id: F6SL91
db: uniprot

uniprot Q8RE31 326
type: UnificationXref
id: Q8RE31
db: uniprot

uniprot Q920P5 330
type: UnificationXref
id: Q920P5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SL91 395
organism: Monodelphis domestica

Probable UMP-CMP kinase 1
type: ProteinReference
xref: uniprot Q8VY84 328
organism: Arabidopsis thaliana

uniprot H2PZ67 284
type: UnificationXref
id: H2PZ67
db: uniprot

uniprot A3KN12 157
type: UnificationXref
id: A3KN12
db: uniprot

ncbitaxon 190304 102
type: UnificationXref
id: 190304
db: ncbitaxon

uniprot Q9X0X6 217
type: UnificationXref
id: Q9X0X6
db: uniprot

uniprot P00570 291
type: UnificationXref
id: P00570
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q7KWJ4 172
organism: Plasmodium falciparum

uniprot P9WHM9 557
type: UnificationXref
id: P9WHM9
db: uniprot

uniprot F7DFY8 191
type: UnificationXref
id: F7DFY8
db: uniprot

uniprot P91134 105
type: UnificationXref
id: P91134
db: uniprot

PARTICIPANT STOICHIOMETRY r13 629
type: Stoichiometry
physical entity: NAD
stoichiometric coefficient: 1.0

uniprot P15640 551
type: UnificationXref
id: P15640
db: uniprot

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot P58793 101
xref: PTHR11846:SF0
organism: Fusobacterium nucleatum

uniprot Q10R17 108
type: UnificationXref
id: Q10R17
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

Ribonucleoside-diphosphate reductase large chain 2
type: ProteinReference
xref: uniprot P21672 415
organism: Saccharomyces cerevisiae

Adenylosuccinate synthetase isozyme 2
type: ProteinReference
xref: uniprot Q5ZJL5 114
organism: Gallus gallus

uniprot F1P797 190
type: UnificationXref
id: F1P797
db: uniprot

PARTICIPANT STOICHIOMETRY r13 632
type: Stoichiometry
physical entity: NADH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 631
type: Stoichiometry
physical entity: IMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 630
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot Q382Q1 442
type: UnificationXref
id: Q382Q1
db: uniprot

uniprot P9WMS7 363
type: UnificationXref
id: P9WMS7
db: uniprot

uniprot Q9RT91 381
type: UnificationXref
id: Q9RT91
db: uniprot

uniprot Q58970 367
type: UnificationXref
id: Q58970
db: uniprot

PARTICIPANT STOICHIOMETRY r13 633
type: Stoichiometry
physical entity: xanthosine-5-phosphate
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__5_phosphoribosyl_5_amino_4_imidazole-_10_formyl_THF-RIGHT__phosphoribosyl_formamido_carboxamide-_THF-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 601
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 598
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 599
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 600
left: 10-formyl-THF
left: 5-phosphoribosyl-5-amino-4-imidazole
interaction type: STATE_TRANSITION
right: THF
right: phosphoribosyl-formamido-carboxamide

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__glutamine-_PRPP-_H2O-RIGHT__PPi-_glutamate-_5_phosphoribosylamine-_r1
controller: Amidophosphoribosyl transferase

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8CIH9 518
organism: Mus musculus

Candida albicans
type: BioSource
xref: ncbitaxon 237561 251

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q27601 511
organism: Drosophila melanogaster

Guanylate kinase
type: Protein
entity reference: Guanylate kinase
comment: SPECIES_TYPE=PROTEIN

uniprot P42170 422
type: UnificationXref
id: P42170
db: uniprot

Ribonucleoside-diphosphate reductase subunit alpha
type: ProteinReference
xref: uniprot O84834 408
organism: Chlamydia trachomatis

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot O84835 409
organism: Chlamydia trachomatis

Amidophosphoribosyltransferase
type: ProteinReference
xref: uniprot Q22134 510
organism: Caenorhabditis elegans

uniprot Q9P772 380
type: UnificationXref
id: Q9P772
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot Q8RGD3 175
organism: Fusobacterium nucleatum

uniprot A0A3Q1LUN6 351
type: UnificationXref
id: A0A3Q1LUN6
db: uniprot

uniprot A8XAI1 387
type: UnificationXref
id: A8XAI1
db: uniprot

uniprot O66503 405
type: UnificationXref
id: O66503
db: uniprot

uniprot I6XWA1 160
type: UnificationXref
id: I6XWA1
db: uniprot

10-Formyl-THF
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Adenylosuccinate synthetase isozyme 2
type: ProteinReference
xref: uniprot F1Q4F5 89
xref: PTHR11846:SF13
organism: Canis lupus familiaris

5-phosphoribosylamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q96529 124
type: UnificationXref
id: Q96529
db: uniprot

uniprot Q59Q46 250
type: UnificationXref
id: Q59Q46
db: uniprot

GMP synthase [glutamine-hydrolyzing]
type: ProteinReference
xref: uniprot Q8IJR9 370
organism: Plasmodium falciparum

uniprot Q8IJR9 370
type: UnificationXref
id: Q8IJR9
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 79

Adenylate kinase isoenzyme 1
type: ProteinReference
xref: uniprot A8XQX9 272
organism: Caenorhabditis briggsae

Phosphoribosylamine--glycine ligase
type: ProteinReference
xref: uniprot P9WHM9 557
organism: Mycobacterium tuberculosis

uniprot P48591 424
type: UnificationXref
id: P48591
db: uniprot

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot Q4QD53 248
organism: Leishmania major

Bifunctional purine biosynthesis protein PurH
type: ProteinReference
xref: uniprot P9WHM7 203
organism: Mycobacterium tuberculosis

UMP-CMP kinase 4
type: ProteinReference
xref: uniprot Q6K7H2 318
organism: Oryza sativa

AICAR transformylase
type: ProteinReference
xref: P02900
standard name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo purine biosynthesis.PROTEIN.GENERIC.AICAR transformylase
comment: ENTITY_REFERENCE_NOTES=Long Name: AICAR transformylase Synonym: Synonym not specified Accession: P02900
member entity reference: Bifunctional purine biosynthesis protein PURH
member entity reference: Phosphoribosylaminoimidazolecarboxamide formyltransferase
member entity reference: Bifunctional purine biosynthesis protein PurH
member entity reference: AICARFT/IMPCHase bienzyme family protein
member entity reference: Protein CBG17698
member entity reference: Bifunctional purine biosynthesis protein ADE16
member entity reference: Bifunctional purine biosynthesis protein ade10
member entity reference: Bifunctional purine biosynthesis protein ADE17
member entity reference: AGAP001423-PA
member entity reference: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
member entity reference: Phosphoribosylaminoimidazole-succinocarboxamide formyltransferase
member entity reference: RE29555p
member entity reference: Bifunctional purine biosynthesis protein purH
member entity reference: 5-Aminoimidazole-4-carboxamide ribonucleotide formylTransferase/IMP Cyclohydrolase homolog
member entity reference: Uncharacterized protein

uniprot Q68FP8 317
type: UnificationXref
id: Q68FP8
db: uniprot

uniprot Q0VCK0 204
type: UnificationXref
id: Q0VCK0
db: uniprot

Nucleoside diphosphate kinase homolog 5
type: ProteinReference
xref: uniprot Q99MH5 149
organism: Mus musculus

PANTHER Pathway P02738 1
type: UnificationXref
id: P02738
db: PANTHER Pathway

uniprot P9WKF5 306
type: UnificationXref
id: P9WKF5
db: uniprot

Adenylosuccinate lyase
type: ProteinReference
xref: uniprot I6XWA1 160
organism: Mycobacterium tuberculosis

ncbitaxon 185431 60
type: UnificationXref
id: 185431
db: ncbitaxon

Ribonucleotide reductase small subunit
type: ProteinReference
xref: uniprot Q8IM38 455
organism: Plasmodium falciparum

uniprot Q13232 58
type: UnificationXref
id: Q13232
db: uniprot

Adenylosuccinate synthetase
type: ProteinReference
xref: uniprot P9WHN3 106
xref: PTHR11846:SF0
organism: Mycobacterium tuberculosis

ncbitaxon 226186 186
type: UnificationXref
id: 226186
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__5_phosphoribosyl_5_aminoimidazole-_H2O-_CO2-_ATP-RIGHT__ADP-_PO4-_N5_carboxyamino_imidazol_ribonucleotide-_r5
controller: Phosphoribosylformylglycinamide cyclo-ligase

uniprot F1PMF2 138
type: UnificationXref
id: F1PMF2
db: uniprot

uniprot D4A7M6 388
type: UnificationXref
id: D4A7M6
db: uniprot

Adenylate kinase
type: ProteinReference
xref: uniprot Q9X1I8 345
organism: Thermotoga maritima

Adenylate kinase
type: ProteinReference
xref: uniprot O84130 289
organism: Chlamydia trachomatis

Inosine-5'-monophosphate dehydrogenase
type: ProteinReference
xref: uniprot P0ADG7 235
organism: Escherichia coli

uniprot Q8I1T1 323
type: UnificationXref
id: Q8I1T1
db: uniprot

uniprot Q59636 63
type: UnificationXref
id: Q59636
db: uniprot

phosphoribosyl carboxy aminoimidazole
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9031 115
type: UnificationXref
id: 9031
db: ncbitaxon

Nucleoside diphosphate kinase, cytosolic
type: ProteinReference
xref: uniprot P22887 36
organism: Dictyostelium discoideum

uniprot P04046 504
type: UnificationXref
id: P04046
db: uniprot