uniprot Q89DE3 286
type: UnificationXref
id: Q89DE3
db: uniprot

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot P73717 278
organism: Synechocystis

tRNA(Ile)-lysidine synthase
type: ProteinReference
xref: uniprot Q9RV23 292
organism: Deinococcus radiodurans

uniprot P21672 153
type: UnificationXref
id: P21672
db: uniprot

Ribonucleoside-diphosphate reductase 2 subunit beta
type: ProteinReference
xref: uniprot P37146 158
organism: Escherichia coli

uniprot F7HA84 16
type: UnificationXref
id: F7HA84
db: uniprot

uniprot O31875 142
type: UnificationXref
id: O31875
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P36010 42
organism: Saccharomyces cerevisiae

uniprot P00452 148
type: UnificationXref
id: P00452
db: uniprot

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: uniprot P48592 163
organism: Drosophila melanogaster

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot A5PK70 4
organism: Bos taurus

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot P48591 162
organism: Drosophila melanogaster

TTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gloeobacter violaceus
type: BioSource
xref: ncbitaxon 251221 284

ncbitaxon 226186 238
type: UnificationXref
id: 226186
db: ncbitaxon

DeoxyUTPase
type: ProteinReference
xref: uniprot G5EET2 244
organism: Caenorhabditis elegans

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot P23921 154
organism: Homo sapiens

uniprot P50620 165
type: UnificationXref
id: P50620
db: uniprot

uniprot Q9AK79 291
type: UnificationXref
id: Q9AK79
db: uniprot

ncbitaxon 1111708 52
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot E1BFQ8 124
type: UnificationXref
id: E1BFQ8
db: uniprot

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot O69981 145
organism: Streptomyces coelicolor

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q9I4I1 204
organism: Pseudomonas aeruginosa

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot Q9I4I2 205
organism: Pseudomonas aeruginosa

uniprot P74494 51
type: UnificationXref
id: P74494
db: uniprot

Ribonucleoside-diphosphate reductase NrdEB subunit alpha
type: ProteinReference
xref: uniprot O31875 142
organism: Bacillus subtilis

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q59636 65
organism: Pseudomonas aeruginosa

ncbitaxon 83333 95
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot P12461 100
type: UnificationXref
id: P12461
db: uniprot

uniprot P28248 275
type: UnificationXref
id: P28248
db: uniprot

uniprot P97930 224
type: UnificationXref
id: P97930
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BI58 125
organism: Bos taurus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 34

Thymidylate kinase
type: ProteinReference
xref: uniprot O67099 217
organism: Aquifex aeolicus

uniprot P61136 49
type: UnificationXref
id: P61136
db: uniprot

Thymidylate kinase
type: ProteinReference
xref: uniprot P23919 221
organism: Homo sapiens

uniprot Q582G3 105
type: UnificationXref
id: Q582G3
db: uniprot

uniprot Q9RZL6 209
type: UnificationXref
id: Q9RZL6
db: uniprot

dTMP kinase
type: ProteinReference
xref: P02916
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine deoxyribonucleotide biosynthesis.PROTEIN.GENERIC.dTMP kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: dTMP kinase Synonym: Synonym not specified Accession: P02916
member entity reference: Thymidylate kinase
member entity reference: Probable thymidylate kinase
member entity reference: DTYMK isoform 1
member entity reference: AGAP005260-PA
member entity reference: Uncharacterized protein
member entity reference: Deoxythymidylate kinase
member entity reference: CG5757-PA

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot O67475 144
organism: Aquifex aeolicus

ncbitaxon 9615 11
type: UnificationXref
id: 9615
db: ncbitaxon

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 43

CDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P49740 45
type: UnificationXref
id: P49740
db: uniprot

Oxidized Flavodoxin
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 31

uniprot O67528 118
type: UnificationXref
id: O67528
db: uniprot

ADAT2 isoform 2
type: ProteinReference
xref: uniprot H2QTU8 268
organism: Pan troglodytes

ncbitaxon 7165 70
type: UnificationXref
id: 7165
db: ncbitaxon

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot A8XAI1 122
organism: Caenorhabditis briggsae

uniprot E2R8P1 129
type: UnificationXref
id: E2R8P1
db: uniprot

uniprot P22887 37
type: UnificationXref
id: P22887
db: uniprot

uniprot P37146 158
type: UnificationXref
id: P37146
db: uniprot

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot P68398 277
organism: Escherichia coli

uniprot P19804 35
type: UnificationXref
id: P19804
db: uniprot

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot O69719 271
organism: Mycobacterium tuberculosis

uniprot F7CDE0 14
type: UnificationXref
id: F7CDE0
db: uniprot

ncbitaxon 224308 40
type: UnificationXref
id: 224308
db: ncbitaxon

Thymidylate synthase 2
type: ProteinReference
xref: uniprot P11044 99
organism: Bacillus subtilis

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot P06968 251
organism: Escherichia coli

uniprot P33316 253
type: UnificationXref
id: P33316
db: uniprot

uniprot G3V816 17
type: UnificationXref
id: G3V816
db: uniprot

uniprot Q9ADJ9 290
type: UnificationXref
id: Q9ADJ9
db: uniprot

Thymidylate kinase
type: ProteinReference
xref: uniprot P37537 223
organism: Bacillus subtilis

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot Q9K3C2 206
organism: Streptomyces coelicolor

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 84

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dTDP-_ATP-RIGHT__TTP-_ADP-_r7
controller: dTDP kinase

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 109

uniprot F1PEK4 10
type: UnificationXref
id: F1PEK4
db: uniprot

ncbitaxon 227321 76
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot Q7PPZ1 229
type: UnificationXref
id: Q7PPZ1
db: uniprot

uniprot P39452 159
type: UnificationXref
id: P39452
db: uniprot

PARTICIPANT STOICHIOMETRY r7 329
type: Stoichiometry
physical entity: dTDP
stoichiometric coefficient: 1.0

Uncharacterized protein (Fragment) (Fragment)
type: ProteinReference
xref: uniprot B7PXR7 265
organism: Ixodes scapularis

uniprot P09938 150
type: UnificationXref
id: P09938
db: uniprot

uniprot P37537 223
type: UnificationXref
id: P37537
db: uniprot

uniprot Q8TFN0 75
type: UnificationXref
id: Q8TFN0
db: uniprot

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot O52597 246
organism: Bradyrhizobium diazoefficiens

Thymidylate synthase
type: ProteinReference
xref: uniprot Q8RGP6 110
organism: Fusobacterium nucleatum

uniprot Q5A0N3 185
type: UnificationXref
id: Q5A0N3
db: uniprot

Ribonucleoside-diphosphate reductase small chain 1
type: ProteinReference
xref: uniprot P09938 150
organism: Saccharomyces cerevisiae

ncbitaxon 251221 284
type: UnificationXref
id: 251221
db: ncbitaxon

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q8RH18 195
organism: Fusobacterium nucleatum

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot Q8RH17 194
organism: Fusobacterium nucleatum

uniprot Q6PEE3 189
type: UnificationXref
id: Q6PEE3
db: uniprot

Ribonucleotide reductase M2 polypeptide
type: ProteinReference
xref: uniprot D4A7M6 123
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r7 332
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

AGAP006818-PA
type: ProteinReference
xref: uniprot Q7QIF4 191
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY r7 331
type: Stoichiometry
physical entity: TTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 330
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q7QDW7 107
type: UnificationXref
id: Q7QDW7
db: uniprot

uniprot Q05982 56
type: UnificationXref
id: Q05982
db: uniprot

uniprot P21524 152
type: UnificationXref
id: P21524
db: uniprot

uniprot P50589 47
type: UnificationXref
id: P50589
db: uniprot

uniprot Q07661 57
type: UnificationXref
id: Q07661
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q9U1E1 81
organism: Leishmania major

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q58661 63
organism: Methanocaldococcus jannaschii

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q9K496 207
organism: Streptomyces coelicolor

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 19

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HA84 16
organism: Macaca mulatta

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 68

Thymidylate kinase
type: ProteinReference
xref: uniprot Q9X0I3 235
organism: Thermotoga maritima

uniprot Q4VA61 62
type: UnificationXref
id: Q4VA61
db: uniprot

uniprot P45352 102
type: UnificationXref
id: P45352
db: uniprot

uniprot P0A720 220
type: UnificationXref
id: P0A720
db: uniprot

STATE_TRANSITION_LEFT__dUDP-_ATP-RIGHT__dUTP-_ADP-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 305
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 307
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 304
left: ATP
left: dUDP
interaction type: STATE_TRANSITION
right: ADP
right: dUTP

Uncharacterized protein
type: ProteinReference
xref: uniprot H2Q705 20
organism: Pan troglodytes

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P36603 157
type: UnificationXref
id: P36603
db: uniprot

uniprot Q9S7I0 293
type: UnificationXref
id: Q9S7I0
db: uniprot

uniprot Q9WV84 85
type: UnificationXref
id: Q9WV84
db: uniprot

ncbitaxon 190304 111
type: UnificationXref
id: 190304
db: ncbitaxon

dUDP kinase
type: ProteinReference
xref: P02912
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine deoxyribonucleotide biosynthesis.PROTEIN.GENERIC.dUDP kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: dUDP kinase Synonym: Synonym not specified Accession: P02912
member entity reference: Uncharacterized protein
member entity reference: Nucleoside diphosphate kinase
member entity reference: Nucleoside diphosphate kinase A
member entity reference: Nucleoside diphosphate kinase II, chloroplastic
member entity reference: Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase, mitochondrial
member entity reference: Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase B
member entity reference: DS cell adhesion molecule like 1
member entity reference: Nucleoside diphosphate kinase 3
member entity reference: DS cell adhesion molecule-like 1
member entity reference: Down syndrome cell adhesion molecule-like protein 1
member entity reference: Nucleoside diphosphate kinase 1
member entity reference: Nucleoside diphosphate kinase, cytosolic
member entity reference: Down syndrome cell adhesion molecule-like protein 1 homolog

uniprot P9WJH7 53
type: UnificationXref
id: P9WJH7
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot A8WS68 6
organism: Caenorhabditis briggsae

Ribonucleoside-diphosphate reductase subunit alpha
type: ProteinReference
xref: uniprot O66503 143
organism: Aquifex aeolicus

PARTICIPANT STOICHIOMETRY r2 310
type: Stoichiometry
physical entity: dUDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 311
type: Stoichiometry
physical entity: RSSR
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot P50621 166
organism: Bacillus subtilis

uniprot Q9WYL6 241
type: UnificationXref
id: Q9WYL6
db: uniprot

Ribonucleoside-diphosphate reductase subunit alpha
type: ProteinReference
xref: uniprot P50620 165
organism: Bacillus subtilis

PARTICIPANT STOICHIOMETRY r2 309
type: Stoichiometry
physical entity: UDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 308
type: Stoichiometry
physical entity: RSH
stoichiometric coefficient: 1.0

Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
type: ProteinReference
xref: uniprot O49203 25
organism: Arabidopsis thaliana

uniprot Q57872 280
type: UnificationXref
id: Q57872
db: uniprot

Ribonucleoside triphosphate Reductase
type: Protein
entity reference: Ribonucleoside triphosphate Reductase
comment: SPECIES_TYPE=PROTEIN

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: uniprot P11157 151
organism: Mus musculus

ncbitaxon 36329 109
type: UnificationXref
id: 36329
db: ncbitaxon

Down syndrome cell adhesion molecule-like protein 1 homolog
type: ProteinReference
xref: uniprot Q4VA61 62
organism: Mus musculus

uniprot Q95Y87 289
type: UnificationXref
id: Q95Y87
db: uniprot

AGAP010159-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q0U6 257
organism: Anopheles gambiae

uniprot Q9I6F1 112
type: UnificationXref
id: Q9I6F1
db: uniprot

Thymidylate kinase
type: ProteinReference
xref: uniprot Q55593 227
organism: Synechocystis

uniprot Q9U1E1 81
type: UnificationXref
id: Q9U1E1
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: uniprot P04818 90
organism: Homo sapiens

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P74494 51
organism: Synechocystis

uniprot P07742 149
type: UnificationXref
id: P07742
db: uniprot

Ribonucleoside-diphosphate reductase subunit M2 B
type: ProteinReference
xref: uniprot Q7LG56 190
organism: Homo sapiens

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot Q382Q1 180
organism: Trypanosoma brucei

tRNA-specific adenosine deaminase subunit TAD2
type: ProteinReference
xref: uniprot P47058 276
organism: Saccharomyces cerevisiae

Reduced Flavodoxin
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Down syndrome cell adhesion molecule-like protein 1
type: ProteinReference
xref: uniprot Q8TD84 74
organism: Homo sapiens

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot Q382Q0 179
organism: Trypanosoma brucei

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot Q382Q3 182
organism: Trypanosoma brucei

Ribonucleoside-diphosphate reductase small chain A
type: ProteinReference
xref: uniprot P50651 167
organism: Arabidopsis thaliana

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot Q382Q2 181
organism: Trypanosoma brucei

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QT00 242
organism: Macaca mulatta

uniprot G5EET2 244
type: UnificationXref
id: G5EET2
db: uniprot

Nucleoside diphosphate kinase A
type: ProteinReference
xref: uniprot Q05982 56
organism: Rattus norvegicus

AGAP010457-PA
type: ProteinReference
xref: uniprot Q7QDW7 107
organism: Anopheles gambiae

5,10-CH2-THF
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P0CI79 96
type: UnificationXref
id: P0CI79
db: uniprot

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot P70583 255
organism: Rattus norvegicus

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot Q9HPG8 202
organism: Halobacterium salinarum

AGAP005260-PA
type: ProteinReference
xref: uniprot Q7PPZ1 229
organism: Anopheles gambiae

ncbitaxon 9031 127
type: UnificationXref
id: 9031
db: ncbitaxon

Nucleoside diphosphate kinase B
type: ProteinReference
xref: uniprot P19804 35
organism: Rattus norvegicus

dCTP deaminase
type: ProteinReference
xref: P02920
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: dCTP deaminase Synonym: Synonym not specified Accession: P02920
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine deoxyribonucleotide biosynthesis.PROTEIN.GENERIC.dCTP deaminase
member entity reference: tRNA(adenine(34)) deaminase, chloroplastic
member entity reference: tRNA-specific adenosine deaminase
member entity reference: Uncharacterized protein
member entity reference: ADAT2 isoform 2
member entity reference: tRNA-specific adenosine deaminase 2
member entity reference: Guanine deaminase
member entity reference: Putative deaminase
member entity reference: Protein CBG09150
member entity reference: Uncharacterized protein (Fragment) (Fragment)
member entity reference: dCTP deaminase
member entity reference: RE41712p
member entity reference: tRNA(Ile)-lysidine synthase
member entity reference: dCTP deaminase, dUMP-forming
member entity reference: tRNA-specific adenosine deaminase subunit tad2
member entity reference: tRNA-specific adenosine deaminase subunit TAD2
member entity reference: Cytidine/deoxycytidylate deaminase family protein

uniprot A0A1D5Q2L2 120
type: UnificationXref
id: A0A1D5Q2L2
db: uniprot

uniprot Q8RH17 194
type: UnificationXref
id: Q8RH17
db: uniprot

uniprot Q9RR67 114
type: UnificationXref
id: Q9RR67
db: uniprot

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot P79732 171
organism: Danio rerio

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot P07382 92
organism: Leishmania major

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: uniprot P79733 172
organism: Danio rerio

Ribonucleoside-diphosphate reductase 1 subunit beta
type: ProteinReference
xref: uniprot P69924 168
organism: Escherichia coli

uniprot Q54BK9 279
type: UnificationXref
id: Q54BK9
db: uniprot

Anaerobic ribonucleoside-triphosphate reductase
type: ProteinReference
xref: uniprot Q8A688 237
organism: Bacteroides thetaiotaomicron

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GAS0 267
organism: Macaca mulatta

7,8-DHF
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6TKJ2 133
type: UnificationXref
id: F6TKJ2
db: uniprot

tRNA-specific adenosine deaminase subunit tad2
type: ProteinReference
xref: uniprot O94642 273
organism: Schizosaccharomyces pombe

Thymidylate kinase
type: ProteinReference
xref: uniprot P0A720 220
organism: Escherichia coli

ncbitaxon 6239 80
type: UnificationXref
id: 6239
db: ncbitaxon

dCTP deaminase
type: Protein
entity reference: dCTP deaminase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 10090 34
type: UnificationXref
id: 10090
db: ncbitaxon

Ribonucleoside-diphosphate reductase subunit alpha
type: ProteinReference
xref: uniprot P9WH75 175
organism: Mycobacterium tuberculosis

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot P21335 274
organism: Bacillus subtilis

uniprot Q8LAH8 73
type: UnificationXref
id: Q8LAH8
db: uniprot

Vitamin B12-dependent ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot P9WH77 176
organism: Mycobacterium tuberculosis

Thymidylate synthase
type: ProteinReference
xref: uniprot O76511 89
organism: Drosophila melanogaster

uniprot F7H337 215
type: UnificationXref
id: F7H337
db: uniprot

NH3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r10 319
type: Stoichiometry
physical entity: NH3
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: uniprot P31350 155
organism: Homo sapiens

Ribonucleoside-diphosphate reductase subunit beta nrdF2
type: ProteinReference
xref: uniprot P9WH71 173
organism: Mycobacterium tuberculosis

PARTICIPANT STOICHIOMETRY r10 318
type: Stoichiometry
physical entity: dCTP
stoichiometric coefficient: 1.0

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot F6TWB9 12
organism: Ornithorhynchus anatinus

uniprot P74240 169
type: UnificationXref
id: P74240
db: uniprot

PARTICIPANT STOICHIOMETRY r10 317
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase subunit beta nrdF1
type: ProteinReference
xref: uniprot P9WH73 174
organism: Mycobacterium tuberculosis

ncbitaxon 13616 132
type: UnificationXref
id: 13616
db: ncbitaxon

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot F7A4H4 136
organism: Monodelphis domestica

uniprot P9WH73 174
type: UnificationXref
id: P9WH73
db: uniprot

uniprot Q9HNV4 232
type: UnificationXref
id: Q9HNV4
db: uniprot

uniprot Q8IM38 193
type: UnificationXref
id: Q8IM38
db: uniprot

ncbitaxon 9544 15
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot P08879 30
type: UnificationXref
id: P08879
db: uniprot

uniprot A1ZB29 213
type: UnificationXref
id: A1ZB29
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot G3V816 17
organism: Rattus norvegicus

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 40

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot P07742 149
organism: Mus musculus

uniprot Q9P6Q5 261
type: UnificationXref
id: Q9P6Q5
db: uniprot

uniprot A8XAI1 122
type: UnificationXref
id: A8XAI1
db: uniprot

uniprot O66503 143
type: UnificationXref
id: O66503
db: uniprot

uniprot P48592 163
type: UnificationXref
id: P48592
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 5

PARTICIPANT STOICHIOMETRY r5 296
type: Stoichiometry
physical entity: dUMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 297
type: Stoichiometry
physical entity: 5,10-CH2-THF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 298
type: Stoichiometry
physical entity: 7,8-DHF
stoichiometric coefficient: 1.0

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 15

PARTICIPANT STOICHIOMETRY r5 299
type: Stoichiometry
physical entity: dTMP
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot Q9C167 199
organism: Neurospora crassa

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P08879 30
organism: Drosophila melanogaster

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 13

uniprot Q9C167 199
type: UnificationXref
id: Q9C167
db: uniprot

tRNA-specific adenosine deaminase 2
type: ProteinReference
xref: uniprot Q7Z6V5 285
organism: Homo sapiens

tRNA-specific adenosine deaminase 2
type: ProteinReference
xref: uniprot Q6P6J0 282
organism: Mus musculus

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q8TFN0 75
organism: Emericella nidulans

uniprot O30601 141
type: UnificationXref
id: O30601
db: uniprot

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot Q89DE3 286
organism: Bradyrhizobium diazoefficiens

Uncharacterized protein
type: ProteinReference
xref: uniprot Q19599 178
organism: Caenorhabditis elegans

dCTP deaminase, dUMP-forming
type: ProteinReference
xref: uniprot Q57872 280
organism: Methanocaldococcus jannaschii

RSSR
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

STATE_TRANSITION_LEFT__ATP-_dTMP-RIGHT__dTDP-_ADP-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 334
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 335
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 333
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 336
left: dTMP
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: dTDP

Thymidylate kinase
type: ProteinReference
xref: uniprot Q1K688 225
organism: Neurospora crassa

uniprot Q9UW15 212
type: UnificationXref
id: Q9UW15
db: uniprot

uniprot Q8I1R6 108
type: UnificationXref
id: Q8I1R6
db: uniprot

CDP Reductase
type: Protein
entity reference: CDP Reductase
comment: SPECIES_TYPE=PROTEIN

Thymidylate synthase
type: ProteinReference
xref: uniprot P07607 93
organism: Mus musculus

uniprot Q382Q1 180
type: UnificationXref
id: Q382Q1
db: uniprot

PARTICIPANT STOICHIOMETRY r1 316
type: Stoichiometry
physical entity: Oxidized Flavodoxin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 315
type: Stoichiometry
physical entity: dUTP
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot E2R8P1 129
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r1 314
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot O69981 145
type: UnificationXref
id: O69981
db: uniprot

PARTICIPANT STOICHIOMETRY r1 313
type: Stoichiometry
physical entity: Reduced Flavodoxin
stoichiometric coefficient: 1.0

Probable thymidylate kinase
type: ProteinReference
xref: uniprot Q8THS9 230
organism: Methanosarcina acetivorans

uniprot P23919 221
type: UnificationXref
id: P23919
db: uniprot

uniprot P79732 171
type: UnificationXref
id: P79732
db: uniprot

PARTICIPANT STOICHIOMETRY r1 312
type: Stoichiometry
physical entity: UTP
stoichiometric coefficient: 1.0

uniprot H2R8E7 245
type: UnificationXref
id: H2R8E7
db: uniprot

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 78

Nucleoside diphosphate kinase 1
type: ProteinReference
xref: uniprot Q07661 57
organism: Oryza sativa

Nucleoside diphosphate kinase B
type: ProteinReference
xref: uniprot Q01768 55
organism: Mus musculus

uniprot G4FH33 138
type: UnificationXref
id: G4FH33
db: uniprot

uniprot Q7Q0U6 257
type: UnificationXref
id: Q7Q0U6
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P61136 49
organism: Halobacterium salinarum

dTDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 266

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q8TQL6 77
organism: Methanosarcina acetivorans

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P9WJH7 53
organism: Mycobacterium tuberculosis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dUDP-_ATP-RIGHT__dUTP-_ADP-_r3
controller: dUDP kinase

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q9RZL7 210
organism: Deinococcus radiodurans

Ribonucleoside-diphosphate reductase, beta chain
type: ProteinReference
xref: uniprot Q9RZL6 209
organism: Deinococcus radiodurans

uniprot Q9HPG8 202
type: UnificationXref
id: Q9HPG8
db: uniprot

dTMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thymidylate synthase
type: ProteinReference
xref: uniprot P0A884 94
organism: Escherichia coli

Ribonucleoside-diphosphate reductase subunit M2 B
type: ProteinReference
xref: uniprot A0A1D5Q2L2 120
organism: Macaca mulatta

uniprot Q6AZK9 67
type: UnificationXref
id: Q6AZK9
db: uniprot

dUTP pyrophosphatase
type: ProteinReference
xref: P02918
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine deoxyribonucleotide biosynthesis.PROTEIN.GENERIC.dUTP pyrophosphatase
comment: ENTITY_REFERENCE_NOTES=Long Name: dUTP pyrophosphatase Synonym: Synonym not specified Accession: P02918
member entity reference: DUT isoform 2
member entity reference: AGAP010159-PA (Fragment)
member entity reference: BcDNA.LD08534
member entity reference: Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
member entity reference: Deoxyuridine 5'-triphosphate nucleotidohydrolase
member entity reference: Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
member entity reference: Uncharacterized protein
member entity reference: Deoxyuridine triphosphatase
member entity reference: DeoxyUTPase

ncbitaxon 8364 68
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot H2QTU8 268
type: UnificationXref
id: H2QTU8
db: uniprot

uniprot D3ZUJ5 214
type: UnificationXref
id: D3ZUJ5
db: uniprot

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q5A0N3 185
organism: Candida albicans

uniprot P00572 219
type: UnificationXref
id: P00572
db: uniprot

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 119

uniprot P11157 151
type: UnificationXref
id: P11157
db: uniprot

uniprot Q6P045 106
type: UnificationXref
id: Q6P045
db: uniprot

uniprot Q384N4 183
type: UnificationXref
id: Q384N4
db: uniprot

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot Q8ZTP7 197
organism: Pyrobaculum aerophilum

ncbitaxon 224324 119
type: UnificationXref
id: 224324
db: ncbitaxon

Putative deaminase
type: ProteinReference
xref: uniprot Q9ADJ9 290
organism: Streptomyces coelicolor

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 11

uniprot Q8RER7 258
type: UnificationXref
id: Q8RER7
db: uniprot

RSH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ribonucleotide reductase regulatory TP53 inducible subunit M2B
type: ProteinReference
xref: uniprot A0A2I3SX17 121
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r10 320
type: Stoichiometry
physical entity: dUTP
stoichiometric coefficient: 1.0

dUMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O69719 271
type: UnificationXref
id: O69719
db: uniprot

uniprot P9WFR9 103
type: UnificationXref
id: P9WFR9
db: uniprot

uniprot Q95QD6 288
type: UnificationXref
id: Q95QD6
db: uniprot

Probable thymidylate kinase
type: ProteinReference
xref: uniprot Q8ZY35 231
organism: Pyrobaculum aerophilum

ncbitaxon 208964 66
type: UnificationXref
id: 208964
db: ncbitaxon

DTYMK isoform 1
type: ProteinReference
xref: uniprot H2QJR9 216
organism: Pan troglodytes

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 127

Bradyrhizobium diazoefficiens
type: BioSource
xref: ncbitaxon 224911 247

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 198

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot Q03604 177
organism: Caenorhabditis elegans

uniprot F6U4A0 134
type: UnificationXref
id: F6U4A0
db: uniprot

Ribonucleoside-diphosphate reductase large chain
type: ProteinReference
xref: uniprot Q9UW15 212
organism: Neurospora crassa

uniprot G2HEY4 88
type: UnificationXref
id: G2HEY4
db: uniprot

Probable thymidylate kinase
type: ProteinReference
xref: uniprot Q57741 228
organism: Methanocaldococcus jannaschii

Thymidylate synthase
type: ProteinReference
xref: uniprot P12461 100
organism: Candida albicans

uniprot Q19599 178
type: UnificationXref
id: Q19599
db: uniprot

uniprot P15531 32
type: UnificationXref
id: P15531
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 48

STATE_TRANSITION_LEFT__H2O-_dCTP-RIGHT__NH3-_dUTP-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 318
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 320
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 319
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 317
left: dCTP
left: H2O
interaction type: STATE_TRANSITION
right: NH3
right: dUTP

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot H2Q2Y0 140
organism: Pan troglodytes

uniprot P36590 222
type: UnificationXref
id: P36590
db: uniprot

uniprot Q5TNU6 187
type: UnificationXref
id: Q5TNU6
db: uniprot

uniprot P0A884 94
type: UnificationXref
id: P0A884
db: uniprot

uniprot P36602 156
type: UnificationXref
id: P36602
db: uniprot

uniprot Q8THS9 230
type: UnificationXref
id: Q8THS9
db: uniprot

ncbitaxon 367110 84
type: UnificationXref
id: 367110
db: ncbitaxon

Ribonucleoside-diphosphate reductase small subunit
type: ProteinReference
xref: uniprot P42521 161
organism: Dictyostelium discoideum

STATE_TRANSITION
type: RelationshipTypeVocabulary

Ribonucleoside-diphosphate reductase small chain 2
type: ProteinReference
xref: uniprot P49723 164
organism: Saccharomyces cerevisiae

Thymidylate synthetase
type: ProteinReference
xref: uniprot Q6P045 106
organism: Danio rerio

ncbitaxon 83332 54
type: UnificationXref
id: 83332
db: ncbitaxon

uniprot K7BSW8 22
type: UnificationXref
id: K7BSW8
db: uniprot

Ribonucleotide reductase regulatory TP53 inducible subunit M2B
type: ProteinReference
xref: uniprot E1BFQ8 124
organism: Bos taurus

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot O67050 270
organism: Aquifex aeolicus

ncbitaxon 10116 9
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot O67050 270
type: UnificationXref
id: O67050
db: uniprot

uniprot H2Q2Y0 140
type: UnificationXref
id: H2Q2Y0
db: uniprot

uniprot P04818 90
type: UnificationXref
id: P04818
db: uniprot

ncbitaxon 9258 13
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot Q9X0I3 235
type: UnificationXref
id: Q9X0I3
db: uniprot

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot O66592 249
organism: Aquifex aeolicus

uniprot P9WH77 176
type: UnificationXref
id: P9WH77
db: uniprot

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot F1MSF1 130
organism: Bos taurus

uniprot Q9HMU3 200
type: UnificationXref
id: Q9HMU3
db: uniprot

uniprot Q5BHB3 186
type: UnificationXref
id: Q5BHB3
db: uniprot

uniprot Q9VEM0 294
type: UnificationXref
id: Q9VEM0
db: uniprot

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 7

Thymidylate synthase
type: ProteinReference
xref: uniprot Q9N588 113
organism: Caenorhabditis elegans

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P49740 45
organism: Schizosaccharomyces pombe

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 80

uniprot P47058 276
type: UnificationXref
id: P47058
db: uniprot

dTDP kinase
type: Protein
entity reference: dTDP kinase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 39947 58
type: UnificationXref
id: 39947
db: ncbitaxon

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot P9WNS5 256
organism: Mycobacterium tuberculosis

DS cell adhesion molecule like 1
type: ProteinReference
xref: uniprot H2Q4V0 18
organism: Pan troglodytes

Ribonucleotide reductase regulatory subunit M2
type: ProteinReference
xref: uniprot E2R7H9 128
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CDP-_RSH-RIGHT__dCDP-_RSSR-_r8
controller: CDP Reductase

ncbitaxon 214684 98
type: UnificationXref
id: 214684
db: ncbitaxon

uniprot P22392 36
type: UnificationXref
id: P22392
db: uniprot

STATE_TRANSITION_LEFT__dUMP-_5,10_CH2_THF-RIGHT__7,8_DHF-_dTMP-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 298
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 299
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 297
left: 5,10-CH2-THF
left: dUMP
interaction type: STATE_TRANSITION
right: dTMP
right: 7,8-DHF

uniprot P15532 33
type: UnificationXref
id: P15532
db: uniprot

uniprot Q9RV23 292
type: UnificationXref
id: Q9RV23
db: uniprot

PANTHER Pathway P02739 1
type: UnificationXref
id: P02739
db: PANTHER Pathway

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot Q9HTN3 260
organism: Pseudomonas aeruginosa

Thymidylate kinase
type: ProteinReference
xref: uniprot Q9RY40 234
organism: Deinococcus radiodurans

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot G4FH33 138
organism: Thermotoga maritima

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_dTMP-RIGHT__dTDP-_ADP-_r6
controller: dTMP kinase

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot A0A0R4IS05 2
organism: Danio rerio

uniprot Q9STG6 262
type: UnificationXref
id: Q9STG6
db: uniprot

Ribonucleoside-diphosphate reductase large subunit
type: ProteinReference
xref: uniprot Q9SJ20 211
organism: Arabidopsis thaliana

uniprot Q9SJ20 211
type: UnificationXref
id: Q9SJ20
db: uniprot

ncbitaxon 3702 26
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot Q7MBC0 283
type: UnificationXref
id: Q7MBC0
db: uniprot

uniprot P06785 91
type: UnificationXref
id: P06785
db: uniprot

P02921
type: UnificationXref
id: P02921
db: PANTHER Pathway Component

P02920
type: UnificationXref
id: P02920
db: PANTHER Pathway Component

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot O54134 248
organism: Streptomyces coelicolor

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 58

dCDP kinase
type: ProteinReference
xref: P02914
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine deoxyribonucleotide biosynthesis.PROTEIN.GENERIC.dCDP kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: dCDP kinase Synonym: Synonym not specified Accession: P02914
member entity reference: Uncharacterized protein
member entity reference: Nucleoside diphosphate kinase
member entity reference: Nucleoside diphosphate kinase A
member entity reference: Nucleoside diphosphate kinase II, chloroplastic
member entity reference: Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase, mitochondrial
member entity reference: Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase B
member entity reference: DS cell adhesion molecule like 1
member entity reference: Nucleoside diphosphate kinase 3
member entity reference: DS cell adhesion molecule-like 1
member entity reference: Down syndrome cell adhesion molecule-like protein 1
member entity reference: Nucleoside diphosphate kinase 1
member entity reference: Nucleoside diphosphate kinase, cytosolic
member entity reference: Down syndrome cell adhesion molecule-like protein 1 homolog

Probable thymidylate synthase
type: ProteinReference
xref: uniprot Q9UTI7 117
organism: Schizosaccharomyces pombe

uniprot P23921 154
type: UnificationXref
id: P23921
db: uniprot

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 66

Ribonucleotide reductase
type: ProteinReference
xref: uniprot Q5BHB3 186
organism: Emericella nidulans

dCDP kinase
type: Protein
entity reference: dCDP kinase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9N588 113
type: UnificationXref
id: Q9N588
db: uniprot

uniprot P34093 41
type: UnificationXref
id: P34093
db: uniprot

ncbitaxon 7955 3
type: UnificationXref
id: 7955
db: ncbitaxon

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q9RRW1 208
organism: Deinococcus radiodurans

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 50

uniprot E1C4Q0 126
type: UnificationXref
id: E1C4Q0
db: uniprot

uniprot P31350 155
type: UnificationXref
id: P31350
db: uniprot

uniprot P31103 39
type: UnificationXref
id: P31103
db: uniprot

uniprot Q7Z6V5 285
type: UnificationXref
id: Q7Z6V5
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q93576 79
organism: Caenorhabditis elegans

uniprot F6Z9D7 135
type: UnificationXref
id: F6Z9D7
db: uniprot

uniprot P68398 277
type: UnificationXref
id: P68398
db: uniprot

Ribonucleoside-diphosphate reductase (Fragment)
type: ProteinReference
xref: uniprot Q5TNU6 187
organism: Anopheles gambiae

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot Q582G3 105
organism: Trypanosoma brucei

uniprot Q8ZY35 231
type: UnificationXref
id: Q8ZY35
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 70

Deoxyuridine triphosphatase
type: ProteinReference
xref: uniprot Q8VCG1 259
organism: Mus musculus

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot Q8TQ86 196
organism: Methanosarcina acetivorans

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 98

uniprot Q382Q2 181
type: UnificationXref
id: Q382Q2
db: uniprot

uniprot P21335 274
type: UnificationXref
id: P21335
db: uniprot

P02919
type: UnificationXref
id: P02919
db: PANTHER Pathway Component

uniprot P36010 42
type: UnificationXref
id: P36010
db: uniprot

P02918
type: UnificationXref
id: P02918
db: PANTHER Pathway Component

uniprot Q03604 177
type: UnificationXref
id: Q03604
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__UTP-_Reduced_Flavodoxin-RIGHT__H2O-_dUTP-_Oxidized_Flavodoxin-_r1
controller: Ribonucleoside triphosphate Reductase

P02917
type: UnificationXref
id: P02917
db: PANTHER Pathway Component

P02916
type: UnificationXref
id: P02916
db: PANTHER Pathway Component

Thymidylate synthase
type: ProteinReference
xref: P02913
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine deoxyribonucleotide biosynthesis.PROTEIN.GENERIC.Thymidylate synthase
comment: ENTITY_REFERENCE_NOTES=Long Name: Thymidylate synthase Synonym: Synonym not specified Accession: P02913
member entity reference: Thymidylate synthetase
member entity reference: Thymidylate synthase
member entity reference: Thymidylate synthase ThyA
member entity reference: AGAP010457-PA
member entity reference: Bifunctional dihydrofolate reductase-thymidylate synthase
member entity reference: Fibronectin 1
member entity reference: Thymidylate synthase 2
member entity reference: Uncharacterized protein
member entity reference: Probable thymidylate synthase
member entity reference: Thymidylate synthase 1
member entity reference: Bifunctional dihydrofolate reductase-thymidylate synthase 1

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9XXD0 295
organism: Caenorhabditis elegans

ncbitaxon 6238 7
type: UnificationXref
id: 6238
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r4 300
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

P02915
type: UnificationXref
id: P02915
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r4 301
type: Stoichiometry
physical entity: dUTP
stoichiometric coefficient: 1.0

P02914
type: UnificationXref
id: P02914
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r4 302
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

Thymidylate kinase
type: ProteinReference
xref: uniprot Q9HZN8 233
organism: Pseudomonas aeruginosa

P02913
type: UnificationXref
id: P02913
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r4 303
type: Stoichiometry
physical entity: dUMP
stoichiometric coefficient: 1.0

P02912
type: UnificationXref
id: P02912
db: PANTHER Pathway Component

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 29

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 139

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dUMP-_5,10_CH2_THF-RIGHT__7,8_DHF-_dTMP-_r5
controller: Thymidylate synthase

Probable thymidylate kinase
type: ProteinReference
xref: uniprot Q9HNV4 232
organism: Halobacterium salinarum

Thymidylate synthase
type: Protein
entity reference: Thymidylate synthase
comment: SPECIES_TYPE=PROTEIN

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q384N4 183
organism: Trypanosoma brucei

uniprot Q382Q0 179
type: UnificationXref
id: Q382Q0
db: uniprot

uniprot Q9RRW1 208
type: UnificationXref
id: Q9RRW1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q95Y87 289
organism: Caenorhabditis elegans

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 52

uniprot Q55593 227
type: UnificationXref
id: Q55593
db: uniprot

Thymidylate kinase
type: ProteinReference
xref: uniprot Q22018 226
organism: Caenorhabditis elegans

uniprot P9WH71 173
type: UnificationXref
id: P9WH71
db: uniprot

uniprot F6TWB9 12
type: UnificationXref
id: F6TWB9
db: uniprot

uniprot Q8RGP6 110
type: UnificationXref
id: Q8RGP6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_dCTP-RIGHT__NH3-_dUTP-_r10
controller: dCTP deaminase

Cytidine/deoxycytidylate deaminase family protein
type: ProteinReference
xref: uniprot Q8TKJ8 287
organism: Methanosarcina acetivorans

uniprot O49203 25
type: UnificationXref
id: O49203
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: uniprot P0CS12 97
organism: Cryptococcus neoformans

uniprot Q57741 228
type: UnificationXref
id: Q57741
db: uniprot

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot Q9SIK4 116
organism: Arabidopsis thaliana

UDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q8IL94 192
type: UnificationXref
id: Q8IL94
db: uniprot

uniprot Q9X908 236
type: UnificationXref
id: Q9X908
db: uniprot

uniprot O00746 23
type: UnificationXref
id: O00746
db: uniprot

ncbitaxon 243232 64
type: UnificationXref
id: 243232
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r6 335
type: Stoichiometry
physical entity: dTDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 336
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Protein CBG09150
type: ProteinReference
xref: uniprot A8X869 264
organism: Caenorhabditis briggsae

uniprot P06968 251
type: UnificationXref
id: P06968
db: uniprot

STATE_TRANSITION_LEFT__ATP-_dCDP-RIGHT__dCTP-_ADP-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 324
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 321
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 323
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 322
left: dCDP
left: ATP
interaction type: STATE_TRANSITION
right: ADP
right: dCTP

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PEK4 10
organism: Canis lupus familiaris

Nucleoside diphosphate kinase A
type: ProteinReference
xref: uniprot P15532 33
organism: Mus musculus

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 132

Nucleoside diphosphate kinase A
type: ProteinReference
xref: uniprot P15531 32
organism: Homo sapiens

ncbitaxon 44689 38
type: UnificationXref
id: 44689
db: ncbitaxon

Thymidylate synthase ThyA
type: ProteinReference
xref: uniprot P9WFR9 103
organism: Mycobacterium tuberculosis

ncbitaxon 178306 198
type: UnificationXref
id: 178306
db: ncbitaxon

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot P0CY19 252
organism: Candida albicans

ncbitaxon 224911 247
type: UnificationXref
id: 224911
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GGT3 137
organism: Monodelphis domestica

Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
type: ProteinReference
xref: uniprot P33316 253
organism: Homo sapiens

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot P33317 254
organism: Saccharomyces cerevisiae

Thymidylate synthase
type: ProteinReference
xref: uniprot Q9RR67 114
organism: Deinococcus radiodurans

Bacteroides thetaiotaomicron
type: BioSource
xref: ncbitaxon 226186 238

PARTICIPANT STOICHIOMETRY r9 322
type: Stoichiometry
physical entity: dCDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 321
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 324
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q8TUJ5 240
type: UnificationXref
id: Q8TUJ5
db: uniprot

PARTICIPANT STOICHIOMETRY r9 323
type: Stoichiometry
physical entity: dCTP
stoichiometric coefficient: 1.0

Ribonucleoside-diphosphate reductase subunit M2 B
type: ProteinReference
xref: uniprot Q6PEE3 189
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r6 334
type: Stoichiometry
physical entity: dTMP
stoichiometric coefficient: 1.0

uniprot Q01768 55
type: UnificationXref
id: Q01768
db: uniprot

PARTICIPANT STOICHIOMETRY r6 333
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Anaerobic ribonucleoside-triphosphate reductase
type: ProteinReference
xref: uniprot Q8TUJ5 240
organism: Methanosarcina acetivorans

ncbitaxon 188937 78
type: UnificationXref
id: 188937
db: ncbitaxon

tRNA(adenine(34)) deaminase, chloroplastic
type: ProteinReference
xref: uniprot Q9S7I0 293
organism: Arabidopsis thaliana

dTDP kinase
type: ProteinReference
xref: P02919
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine deoxyribonucleotide biosynthesis.PROTEIN.GENERIC.dTDP kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: dTDP kinase Synonym: Synonym not specified Accession: P02919
member entity reference: Uncharacterized protein
member entity reference: Nucleoside diphosphate kinase
member entity reference: Nucleoside diphosphate kinase A
member entity reference: Nucleoside diphosphate kinase II, chloroplastic
member entity reference: Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase, mitochondrial
member entity reference: Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase B
member entity reference: DS cell adhesion molecule like 1
member entity reference: Nucleoside diphosphate kinase 3
member entity reference: DS cell adhesion molecule-like 1
member entity reference: Down syndrome cell adhesion molecule-like protein 1
member entity reference: Nucleoside diphosphate kinase 1
member entity reference: Nucleoside diphosphate kinase, cytosolic
member entity reference: Down syndrome cell adhesion molecule-like protein 1 homolog

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 46

uniprot Q7QIX6 69
type: UnificationXref
id: Q7QIX6
db: uniprot

uniprot O84851 272
type: UnificationXref
id: O84851
db: uniprot

uniprot O76511 89
type: UnificationXref
id: O76511
db: uniprot

BcDNA.LD08534
type: ProteinReference
xref: uniprot Q9V3I1 263
organism: Drosophila melanogaster

uniprot P42521 161
type: UnificationXref
id: P42521
db: uniprot

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot Q9AK79 291
organism: Streptomyces coelicolor

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H337 215
organism: Macaca mulatta

uniprot D3ZPL7 8
type: UnificationXref
id: D3ZPL7
db: uniprot

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot Q8I1R6 108
organism: Plasmodium falciparum

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot Q9HT76 203
organism: Pseudomonas aeruginosa

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot E1C4Q0 126
organism: Gallus gallus

ncbitaxon 559292 43
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot O34598 269
type: UnificationXref
id: O34598
db: uniprot

De novo pyrimidine deoxyribonucleotide biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__RSH-_UDP-RIGHT__dUDP-_RSSR-_r2
pathway component: STATE_TRANSITION_LEFT__dTDP-_ATP-RIGHT__TTP-_ADP-_r7
pathway component: STATE_TRANSITION_LEFT__dUMP-_5,10_CH2_THF-RIGHT__7,8_DHF-_dTMP-_r5
pathway component: STATE_TRANSITION_LEFT__CDP-_RSH-RIGHT__dCDP-_RSSR-_r8
pathway component: STATE_TRANSITION_LEFT__H2O-_dUTP-RIGHT__PPi-_dUMP-_r4
pathway component: STATE_TRANSITION_LEFT__dUDP-_ATP-RIGHT__dUTP-_ADP-_r3
pathway component: STATE_TRANSITION_LEFT__ATP-_dTMP-RIGHT__dTDP-_ADP-_r6
pathway component: STATE_TRANSITION_LEFT__H2O-_dCTP-RIGHT__NH3-_dUTP-_r10
pathway component: STATE_TRANSITION_LEFT__ATP-_dCDP-RIGHT__dCTP-_ADP-_r9
pathway component: STATE_TRANSITION_LEFT__UTP-_Reduced_Flavodoxin-RIGHT__H2O-_dUTP-_Oxidized_Flavodoxin-_r1
xref: PANTHER Pathway P02739 1
comment: MODEL_NOTES=The de novo biosynthesis of pyrimidine deoxyribonucleotides, the monomeric units of DNA. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

uniprot O84835 147
type: UnificationXref
id: O84835
db: uniprot

uniprot Q9K3C2 206
type: UnificationXref
id: Q9K3C2
db: uniprot

ncbitaxon 7227 31
type: UnificationXref
id: 7227
db: ncbitaxon

Deoxythymidylate kinase
type: ProteinReference
xref: uniprot D3ZUJ5 214
organism: Rattus norvegicus

ncbitaxon 6945 266
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot P07382 92
type: UnificationXref
id: P07382
db: uniprot

uniprot A0A2I3SX17 121
type: UnificationXref
id: A0A2I3SX17
db: uniprot

uniprot Q9RZL7 210
type: UnificationXref
id: Q9RZL7
db: uniprot

uniprot O67475 144
type: UnificationXref
id: O67475
db: uniprot

Guanine deaminase
type: ProteinReference
xref: uniprot O34598 269
organism: Bacillus subtilis

uniprot Q9HMU4 201
type: UnificationXref
id: Q9HMU4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_dCDP-RIGHT__dCTP-_ADP-_r9
controller: dCDP kinase

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZRA0 87
organism: Macaca mulatta

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot F6U4A0 134
organism: Ornithorhynchus anatinus

Thymidylate kinase
type: ProteinReference
xref: uniprot P00572 219
organism: Saccharomyces cerevisiae

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q8IL94 192
organism: Plasmodium falciparum

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot O84508 28
organism: Chlamydia trachomatis

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 115

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot Q5VRF5 188
organism: Oryza sativa

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot F6Z9D7 135
organism: Macaca mulatta

uniprot P74732 170
type: UnificationXref
id: P74732
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 24

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 64

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P31103 39
organism: Bacillus subtilis

dTMP kinase
type: Protein
entity reference: dTMP kinase
comment: SPECIES_TYPE=PROTEIN

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot F7CDE0 14
organism: Macaca mulatta

uniprot P48591 162
type: UnificationXref
id: P48591
db: uniprot

uniprot P50651 167
type: UnificationXref
id: P50651
db: uniprot

uniprot Q9HT76 203
type: UnificationXref
id: Q9HT76
db: uniprot

Vitamin B12-dependent ribonucleotide reductase
type: ProteinReference
xref: uniprot Q9HMU3 200
organism: Halobacterium salinarum

Ribonucleoside reductase small chain
type: ProteinReference
xref: uniprot Q9HMU4 201
organism: Halobacterium salinarum

uniprot Q9RY40 234
type: UnificationXref
id: Q9RY40
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 26

uniprot Q9SIK4 116
type: UnificationXref
id: Q9SIK4
db: uniprot

Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
type: ProteinReference
xref: uniprot Q8LAH8 73
organism: Arabidopsis thaliana

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot Q8RER7 258
organism: Fusobacterium nucleatum

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot P74732 170
organism: Synechocystis

uniprot O84834 146
type: UnificationXref
id: O84834
db: uniprot

RE41712p
type: ProteinReference
xref: uniprot Q9VEM0 294
organism: Drosophila melanogaster

uniprot Q9V3I1 263
type: UnificationXref
id: Q9V3I1
db: uniprot

Thymidylate kinase
type: ProteinReference
xref: uniprot P36590 222
organism: Schizosaccharomyces pombe

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q7QIX6 69
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY r8 326
type: Stoichiometry
physical entity: RSH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 327
type: Stoichiometry
physical entity: dCDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 328
type: Stoichiometry
physical entity: RSSR
stoichiometric coefficient: 1.0

dCTP deaminase
type: ProteinReference
xref: uniprot Q7MBC0 283
organism: Gloeobacter violaceus

uniprot P73717 278
type: UnificationXref
id: P73717
db: uniprot

uniprot F7A4H4 136
type: UnificationXref
id: F7A4H4
db: uniprot

PARTICIPANT STOICHIOMETRY r8 325
type: Stoichiometry
physical entity: CDP
stoichiometric coefficient: 1.0

uniprot Q9WV85 86
type: UnificationXref
id: Q9WV85
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 54

uniprot Q9HZN8 233
type: UnificationXref
id: Q9HZN8
db: uniprot

uniprot P11044 99
type: UnificationXref
id: P11044
db: uniprot

uniprot Q9UTI7 117
type: UnificationXref
id: Q9UTI7
db: uniprot

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot O30601 141
organism: Bacillus subtilis

Nucleoside diphosphate kinase 3
type: ProteinReference
xref: uniprot Q13232 59
organism: Homo sapiens

Danio rerio
type: BioSource
xref: ncbitaxon 7955 3

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 95

uniprot Q05762 104
type: UnificationXref
id: Q05762
db: uniprot

uniprot Q8VCG1 259
type: UnificationXref
id: Q8VCG1
db: uniprot

ncbitaxon 243230 115
type: UnificationXref
id: 243230
db: ncbitaxon

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot P42170 160
organism: Caenorhabditis elegans

uniprot P70583 255
type: UnificationXref
id: P70583
db: uniprot

Nucleoside diphosphate kinase, mitochondrial
type: ProteinReference
xref: uniprot Q9WV84 85
organism: Mus musculus

Nucleoside diphosphate kinase 3
type: ProteinReference
xref: uniprot Q9WV85 86
organism: Mus musculus

ncbitaxon 9913 5
type: UnificationXref
id: 9913
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_dUTP-RIGHT__PPi-_dUMP-_r4
controller: dUTP pyrophosphatase

uniprot J9P3S5 21
type: UnificationXref
id: J9P3S5
db: uniprot

uniprot Q8RGI2 239
type: UnificationXref
id: Q8RGI2
db: uniprot

ncbitaxon 185431 61
type: UnificationXref
id: 185431
db: ncbitaxon

Nucleoside diphosphate kinase, mitochondrial
type: ProteinReference
xref: uniprot O00746 23
organism: Homo sapiens

dCTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P0CY19 252
type: UnificationXref
id: P0CY19
db: uniprot

uniprot Q58661 63
type: UnificationXref
id: Q58661
db: uniprot

Thymidylate kinase
type: ProteinReference
xref: uniprot Q9X908 236
organism: Streptomyces coelicolor

Thymidylate synthase
type: ProteinReference
xref: uniprot Q9I6F1 112
organism: Pseudomonas aeruginosa

uniprot O66592 249
type: UnificationXref
id: O66592
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q9UUY8 83
organism: Neurospora crassa

tRNA-specific adenosine deaminase 2
type: ProteinReference
xref: uniprot Q5E9J7 281
organism: Bos taurus

uniprot Q8ZTP7 197
type: UnificationXref
id: Q8ZTP7
db: uniprot

uniprot A5PK70 4
type: UnificationXref
id: A5PK70
db: uniprot

uniprot Q5VRF5 188
type: UnificationXref
id: Q5VRF5
db: uniprot

uniprot Q9XXD0 295
type: UnificationXref
id: Q9XXD0
db: uniprot

Ribonucleoside-diphosphate reductase large chain 1
type: ProteinReference
xref: uniprot P21524 152
organism: Saccharomyces cerevisiae

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 111

STATE_TRANSITION_LEFT__RSH-_UDP-RIGHT__dUDP-_RSSR-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 310
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 311
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 309
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 308
left: RSH
left: UDP
interaction type: STATE_TRANSITION
right: RSSR
right: dUDP

uniprot Q22018 226
type: UnificationXref
id: Q22018
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RSH-_UDP-RIGHT__dUDP-_RSSR-_r2
controller: UDP reductase

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 38

UDP reductase
type: Protein
entity reference: UDP reductase
comment: SPECIES_TYPE=PROTEIN

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q6AZK9 67
organism: Xenopus tropicalis

Ribonucleoside-diphosphate reductase small chain
type: ProteinReference
xref: uniprot P36603 157
organism: Schizosaccharomyces pombe

Ribonucleoside-diphosphate reductase large chain
type: ProteinReference
xref: uniprot P36602 156
organism: Schizosaccharomyces pombe

uniprot P49723 164
type: UnificationXref
id: P49723
db: uniprot

uniprot F1MSF1 130
type: UnificationXref
id: F1MSF1
db: uniprot

uniprot Q5E9J7 281
type: UnificationXref
id: Q5E9J7
db: uniprot

Anaerobic ribonucleoside-triphosphate reductase
type: ProteinReference
xref: uniprot Q8RGI2 239
organism: Fusobacterium nucleatum

ncbitaxon 64091 50
type: UnificationXref
id: 64091
db: ncbitaxon

uniprot H2Q705 20
type: UnificationXref
id: H2Q705
db: uniprot

uniprot Q7XC37 72
type: UnificationXref
id: Q7XC37
db: uniprot

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot O84294 250
organism: Chlamydia trachomatis

Thymidylate kinase
type: ProteinReference
xref: uniprot O84191 218
organism: Chlamydia trachomatis

Ribonucleoside triphosphate Reductase
type: ProteinReference
xref: P02917
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine deoxyribonucleotide biosynthesis.PROTEIN.GENERIC.Ribonucleoside_br_triphosphate_br_Reductase
comment: ENTITY_REFERENCE_NOTES=Long Name: Ribonucleoside triphosphate Reductase Synonym: Synonym not specified Accession: P02917
member entity reference: Anaerobic ribonucleoside-triphosphate reductase
member entity reference: Uncharacterized protein

uniprot P33317 254
type: UnificationXref
id: P33317
db: uniprot

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 61

uniprot O84508 28
type: UnificationXref
id: O84508
db: uniprot

uniprot P79733 172
type: UnificationXref
id: P79733
db: uniprot

Nucleoside diphosphate kinase II, chloroplastic
type: ProteinReference
xref: uniprot O64903 27
organism: Arabidopsis thaliana

Ribonucleoside-diphosphate reductase subunit alpha
type: ProteinReference
xref: uniprot P74240 169
organism: Synechocystis

dCTP deaminase
type: ProteinReference
xref: uniprot P28248 275
organism: Escherichia coli

uniprot H2QJR9 216
type: UnificationXref
id: H2QJR9
db: uniprot

STATE_TRANSITION_LEFT__dTDP-_ATP-RIGHT__TTP-_ADP-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 330
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 329
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 331
left: ATP
left: dTDP
interaction type: STATE_TRANSITION
right: ADP
right: TTP

uniprot Q8TQL6 77
type: UnificationXref
id: Q8TQL6
db: uniprot

DS cell adhesion molecule-like 1
type: ProteinReference
xref: uniprot D3ZPL7 8
organism: Rattus norvegicus

Ribonucleoside-diphosphate reductase 1 subunit alpha
type: ProteinReference
xref: uniprot P00452 148
organism: Escherichia coli

Ribonucleoside-diphosphate reductase 2 subunit alpha
type: ProteinReference
xref: uniprot P39452 159
organism: Escherichia coli

uniprot Q382Q3 182
type: UnificationXref
id: Q382Q3
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q381H3 60
organism: Trypanosoma brucei

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot K7BSW8 22
organism: Pan troglodytes

uniprot Q1K688 225
type: UnificationXref
id: Q1K688
db: uniprot

Ribonucleoside-diphosphate reductase subunit M2
type: ProteinReference
xref: uniprot Q4KLN6 184
organism: Rattus norvegicus

Deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot Q9STG6 262
organism: Arabidopsis thaliana

uniprot Q7QIF4 191
type: UnificationXref
id: Q7QIF4
db: uniprot

UTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O84294 250
type: UnificationXref
id: O84294
db: uniprot

uniprot O54134 248
type: UnificationXref
id: O54134
db: uniprot

uniprot P07607 93
type: UnificationXref
id: P07607
db: uniprot

uniprot Q9UUY8 83
type: UnificationXref
id: Q9UUY8
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 9

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P39207 44
type: UnificationXref
id: P39207
db: uniprot

Ribonucleoside-diphosphate reductase
type: ProteinReference
xref: uniprot F6TKJ2 133
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r3 305
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q8RH18 195
type: UnificationXref
id: Q8RH18
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot O67528 118
organism: Aquifex aeolicus

PARTICIPANT STOICHIOMETRY r3 306
type: Stoichiometry
physical entity: dUTP
stoichiometric coefficient: 1.0

uniprot F7GAS0 267
type: UnificationXref
id: F7GAS0
db: uniprot

PARTICIPANT STOICHIOMETRY r3 307
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q8TKJ8 287
type: UnificationXref
id: Q8TKJ8
db: uniprot

uniprot Q93576 79
type: UnificationXref
id: Q93576
db: uniprot

Thymidylate kinase
type: ProteinReference
xref: uniprot P97930 224
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SL91 131
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY r3 304
type: Stoichiometry
physical entity: dUDP
stoichiometric coefficient: 1.0

uniprot H2Q4V0 18
type: UnificationXref
id: H2Q4V0
db: uniprot

UDP reductase
type: ProteinReference
xref: P02921
comment: ENTITY_REFERENCE_NOTES=Long Name: UDP reductase Synonym: Synonym not specified Accession: P02921
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine deoxyribonucleotide biosynthesis.PROTEIN.GENERIC.UDP reductase
member entity reference: Ribonucleoside-diphosphate reductase
member entity reference: Ribonucleoside-diphosphate reductase 2 subunit beta
member entity reference: Vitamin B12-dependent ribonucleotide reductase
member entity reference: Ribonucleoside-diphosphate reductase small chain
member entity reference: Ribonucleoside-diphosphate reductase (Fragment)
member entity reference: Ribonucleotide reductase M2 polypeptide
member entity reference: Ribonucleoside-diphosphate reductase large chain
member entity reference: Ribonucleotide reductase regulatory subunit M2
member entity reference: Uncharacterized protein
member entity reference: Ribonucleoside-diphosphate reductase subunit M2 B
member entity reference: Ribonucleoside-diphosphate reductase large subunit
member entity reference: Ribonucleoside-diphosphate reductase subunit alpha
member entity reference: SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta
member entity reference: Ribonucleoside-diphosphate reductase subunit beta nrdF1
member entity reference: Ribonucleoside-diphosphate reductase small chain 2
member entity reference: AGAP006818-PA
member entity reference: Ribonucleoside-diphosphate reductase subunit beta
member entity reference: Ribonucleotide reductase regulatory TP53 inducible subunit M2B
member entity reference: Ribonucleoside-diphosphate reductase subunit M2
member entity reference: Ribonucleoside-diphosphate reductase large chain 1
member entity reference: Ribonucleoside-diphosphate reductase small chain A
member entity reference: Ribonucleotide reductase
member entity reference: Ribonucleoside reductase small chain
member entity reference: Ribonucleotide reductase small subunit
member entity reference: Ribonucleoside-diphosphate reductase 1 subunit beta
member entity reference: Ribonucleoside-diphosphate reductase small chain 1
member entity reference: Ribonucleoside-diphosphate reductase, beta chain
member entity reference: Vitamin B12-dependent ribonucleoside-diphosphate reductase
member entity reference: Ribonucleoside-diphosphate reductase subunit beta nrdF2
member entity reference: Ribonucleoside-diphosphate reductase large chain 2

uniprot P0CS12 97
type: UnificationXref
id: P0CS12
db: uniprot

uniprot O64903 27
type: UnificationXref
id: O64903
db: uniprot

uniprot B7PXR7 265
type: UnificationXref
id: B7PXR7
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q7SXL4 71
organism: Danio rerio

uniprot Q7SXL4 71
type: UnificationXref
id: Q7SXL4
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: uniprot P45352 102
organism: Rattus norvegicus

uniprot P69924 168
type: UnificationXref
id: P69924
db: uniprot

uniprot A8WS68 6
type: UnificationXref
id: A8WS68
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P50589 47
organism: Streptomyces coelicolor

ncbitaxon 237561 101
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot Q6P6J0 282
type: UnificationXref
id: Q6P6J0
db: uniprot

uniprot Q9I4I2 205
type: UnificationXref
id: Q9I4I2
db: uniprot

ncbitaxon 100226 48
type: UnificationXref
id: 100226
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot Q95QD6 288
organism: Caenorhabditis elegans

uniprot Q9K496 207
type: UnificationXref
id: Q9K496
db: uniprot

Probable deoxyuridine 5'-triphosphate nucleotidohydrolase
type: ProteinReference
xref: uniprot Q9P6Q5 261
organism: Schizosaccharomyces pombe

STATE_TRANSITION
type: InteractionVocabulary

Ribonucleoside-diphosphate reductase large chain 2
type: ProteinReference
xref: uniprot P21672 153
organism: Saccharomyces cerevisiae

uniprot O84191 218
type: UnificationXref
id: O84191
db: uniprot

uniprot A0A1L1RUW7 243
type: UnificationXref
id: A0A1L1RUW7
db: uniprot

uniprot Q8A688 237
type: UnificationXref
id: Q8A688
db: uniprot

dUTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot J9P3S5 21
organism: Canis lupus familiaris

uniprot Q8TQ86 196
type: UnificationXref
id: Q8TQ86
db: uniprot

ncbitaxon 9606 24
type: UnificationXref
id: 9606
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9WYL6 241
organism: Thermotoga maritima

CDP Reductase
type: ProteinReference
xref: P02915
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine deoxyribonucleotide biosynthesis.PROTEIN.GENERIC.CDP Reductase
comment: ENTITY_REFERENCE_NOTES=Long Name: CDP Reductase Synonym: Synonym not specified Accession: P02915
member entity reference: Ribonucleoside-diphosphate reductase
member entity reference: Ribonucleoside-diphosphate reductase 2 subunit beta
member entity reference: Vitamin B12-dependent ribonucleotide reductase
member entity reference: Ribonucleoside-diphosphate reductase small chain
member entity reference: Ribonucleoside-diphosphate reductase (Fragment)
member entity reference: Ribonucleotide reductase M2 polypeptide
member entity reference: Ribonucleoside-diphosphate reductase large chain
member entity reference: Ribonucleotide reductase regulatory subunit M2
member entity reference: Uncharacterized protein
member entity reference: Ribonucleoside-diphosphate reductase subunit M2 B
member entity reference: Ribonucleoside-diphosphate reductase large subunit
member entity reference: Ribonucleoside-diphosphate reductase subunit alpha
member entity reference: SPBc2 prophage-derived ribonucleoside-diphosphate reductase subunit beta
member entity reference: Ribonucleoside-diphosphate reductase subunit beta nrdF1
member entity reference: Ribonucleoside-diphosphate reductase small chain 2
member entity reference: AGAP006818-PA
member entity reference: Ribonucleoside-diphosphate reductase subunit beta
member entity reference: Ribonucleotide reductase regulatory TP53 inducible subunit M2B
member entity reference: Ribonucleoside-diphosphate reductase subunit M2
member entity reference: Ribonucleoside-diphosphate reductase large chain 1
member entity reference: Ribonucleoside-diphosphate reductase small chain A
member entity reference: Ribonucleotide reductase
member entity reference: Ribonucleoside reductase small chain
member entity reference: Ribonucleotide reductase small subunit
member entity reference: Ribonucleoside-diphosphate reductase 1 subunit beta
member entity reference: Ribonucleoside-diphosphate reductase small chain 1
member entity reference: Ribonucleoside-diphosphate reductase, beta chain
member entity reference: Vitamin B12-dependent ribonucleoside-diphosphate reductase
member entity reference: Ribonucleoside-diphosphate reductase subunit beta nrdF2
member entity reference: Ribonucleoside-diphosphate reductase large chain 2

uniprot F6ZRA0 87
type: UnificationXref
id: F6ZRA0
db: uniprot

uniprot P9WNS5 256
type: UnificationXref
id: P9WNS5
db: uniprot

Candida albicans
type: BioSource
xref: ncbitaxon 237561 101

uniprot A8X869 264
type: UnificationXref
id: A8X869
db: uniprot

STATE_TRANSITION_LEFT__H2O-_dUTP-RIGHT__PPi-_dUMP-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 300
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 302
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 303
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 301
left: H2O
left: dUTP
interaction type: STATE_TRANSITION
right: PPi
right: dUMP

DUT isoform 2
type: ProteinReference
xref: uniprot H2R8E7 245
organism: Pan troglodytes

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q7XC37 72
organism: Oryza sativa

Ribonucleoside-diphosphate reductase subunit alpha
type: ProteinReference
xref: uniprot O84834 146
organism: Chlamydia trachomatis

uniprot A0A0R4IS05 2
type: UnificationXref
id: A0A0R4IS05
db: uniprot

Ribonucleoside-diphosphate reductase subunit beta
type: ProteinReference
xref: uniprot O84835 147
organism: Chlamydia trachomatis

uniprot Q381H3 60
type: UnificationXref
id: Q381H3
db: uniprot

uniprot D4A7M6 123
type: UnificationXref
id: D4A7M6
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: uniprot P06785 91
organism: Saccharomyces cerevisiae

dCTP deaminase
type: ProteinReference
xref: uniprot Q54BK9 279
organism: Dictyostelium discoideum

dUDP kinase
type: Protein
entity reference: dUDP kinase
comment: SPECIES_TYPE=PROTEIN

uniprot E2R7H9 128
type: UnificationXref
id: E2R7H9
db: uniprot

STATE_TRANSITION_LEFT__CDP-_RSH-RIGHT__dCDP-_RSSR-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 328
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 325
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 327
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 326
left: RSH
left: CDP
interaction type: STATE_TRANSITION
right: RSSR
right: dCDP

Leishmania major
type: BioSource
xref: ncbitaxon 5664 82

uniprot Q59636 65
type: UnificationXref
id: Q59636
db: uniprot

ncbitaxon 243274 139
type: UnificationXref
id: 243274
db: ncbitaxon

uniprot P42170 160
type: UnificationXref
id: P42170
db: uniprot

ncbitaxon 272561 29
type: UnificationXref
id: 272561
db: ncbitaxon

STATE_TRANSITION_LEFT__UTP-_Reduced_Flavodoxin-RIGHT__H2O-_dUTP-_Oxidized_Flavodoxin-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 312
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 316
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 313
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 315
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 314
left: Reduced Flavodoxin
left: UTP
interaction type: STATE_TRANSITION
right: Oxidized Flavodoxin
right: H2O
right: dUTP

Nucleoside diphosphate kinase B
type: ProteinReference
xref: uniprot P22392 36
organism: Homo sapiens

uniprot A0A1D5QT00 242
type: UnificationXref
id: A0A1D5QT00
db: uniprot

ncbitaxon 284812 46
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q4KLN6 184
type: UnificationXref
id: Q4KLN6
db: uniprot

Bifunctional dihydrofolate reductase-thymidylate synthase 1
type: ProteinReference
xref: uniprot Q05762 104
organism: Arabidopsis thaliana

uniprot Q8TD84 74
type: UnificationXref
id: Q8TD84
db: uniprot

uniprot Q13232 59
type: UnificationXref
id: Q13232
db: uniprot

Ribonucleotide reductase small subunit
type: ProteinReference
xref: uniprot Q8IM38 193
organism: Plasmodium falciparum

uniprot O52597 246
type: UnificationXref
id: O52597
db: uniprot

uniprot E1BI58 125
type: UnificationXref
id: E1BI58
db: uniprot

Thymidylate synthase 1
type: ProteinReference
xref: uniprot P0CI79 96
organism: Bacillus subtilis

Nucleoside diphosphate kinase, mitochondrial
type: ProteinReference
xref: uniprot P34093 41
organism: Dictyostelium discoideum

uniprot P9WH75 175
type: UnificationXref
id: P9WH75
db: uniprot

uniprot O67099 217
type: UnificationXref
id: O67099
db: uniprot

uniprot F6SL91 131
type: UnificationXref
id: F6SL91
db: uniprot

Nucleoside diphosphate kinase 1
type: ProteinReference
xref: uniprot P39207 44
organism: Arabidopsis thaliana

uniprot P50621 166
type: UnificationXref
id: P50621
db: uniprot

uniprot Q9HTN3 260
type: UnificationXref
id: Q9HTN3
db: uniprot

uniprot F7GGT3 137
type: UnificationXref
id: F7GGT3
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 76

Fibronectin 1
type: ProteinReference
xref: uniprot G2HEY4 88
organism: Pan troglodytes

ncbitaxon 9598 19
type: UnificationXref
id: 9598
db: ncbitaxon

tRNA-specific adenosine deaminase
type: ProteinReference
xref: uniprot O84851 272
organism: Chlamydia trachomatis

dUTP pyrophosphatase
type: Protein
entity reference: dUTP pyrophosphatase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9I4I1 204
type: UnificationXref
id: Q9I4I1
db: uniprot

dUDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O94642 273
type: UnificationXref
id: O94642
db: uniprot

Nucleoside diphosphate kinase, cytosolic
type: ProteinReference
xref: uniprot P22887 37
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1L1RUW7 243
organism: Gallus gallus

CG5757-PA
type: ProteinReference
xref: uniprot A1ZB29 213
organism: Drosophila melanogaster

ncbitaxon 5664 82
type: UnificationXref
id: 5664
db: ncbitaxon

dCDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q7LG56 190
type: UnificationXref
id: Q7LG56
db: uniprot