STATE_TRANSITION_LEFT__carbamoyl_aspartate-RIGHT__dihydroorotate-_H2O-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 298
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 299
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 297
left: carbamoyl-aspartate
interaction type: STATE_TRANSITION
right: H2O
right: dihydroorotate

CTP synthase
type: ProteinReference
xref: uniprot Q9S224 286
organism: Streptomyces coelicolor

uniprot P31103 80
type: UnificationXref
id: P31103
db: uniprot

PARTICIPANT STOICHIOMETRY r5 292
type: Stoichiometry
physical entity: PPi
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 291
type: Stoichiometry
physical entity: orotidine-5-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 290
type: Stoichiometry
physical entity: PRPP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__orotate-_PRPP-RIGHT__orotidine_5_phosphate-_PPi-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 289
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 292
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 290
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 291
left: PRPP
left: orotate
interaction type: STATE_TRANSITION
right: orotidine-5-phosphate
right: PPi

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P36010 82
organism: Saccharomyces cerevisiae

uniprot H2QBH6 199
type: UnificationXref
id: H2QBH6
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot A5PK70 51
organism: Bos taurus

uniprot Q05982 91
type: UnificationXref
id: Q05982
db: uniprot

uniprot P38098 148
type: UnificationXref
id: P38098
db: uniprot

Orotate phosphoribosyltransferase 2
type: ProteinReference
xref: uniprot P30402 16
organism: Saccharomyces cerevisiae

uniprot P36838 147
type: UnificationXref
id: P36838
db: uniprot

uniprot Q8TT55 219
type: UnificationXref
id: Q8TT55
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q59636 99
organism: Pseudomonas aeruginosa

uniprot Q9HP32 281
type: UnificationXref
id: Q9HP32
db: uniprot

uniprot A8WW30 197
type: UnificationXref
id: A8WW30
db: uniprot

ncbitaxon 224324 5
type: UnificationXref
id: 224324
db: ncbitaxon

uniprot Q59636 99
type: UnificationXref
id: Q59636
db: uniprot

Aspartate carbamoyltransferase, chloroplastic
type: ProteinReference
xref: uniprot P49077 180
organism: Arabidopsis thaliana

uniprot O59771 113
type: UnificationXref
id: O59771
db: uniprot

uniprot O66726 177
type: UnificationXref
id: O66726
db: uniprot

ncbitaxon 190304 22
type: UnificationXref
id: 190304
db: ncbitaxon

Giardia intestinalis
type: BioSource
xref: ncbitaxon 184922 249

uniprot P18185 141
type: UnificationXref
id: P18185
db: uniprot

uniprot Q0WRY1 270
type: UnificationXref
id: Q0WRY1
db: uniprot

PARTICIPANT STOICHIOMETRY r5 289
type: Stoichiometry
physical entity: orotate
stoichiometric coefficient: 1.0

Mus musculus
type: BioSource
xref: ncbitaxon 10090 75

uniprot Q9S224 286
type: UnificationXref
id: Q9S224
db: uniprot

uniprot Q9WYG8 225
type: UnificationXref
id: Q9WYG8
db: uniprot

uniprot Q8RG87 163
type: UnificationXref
id: Q8RG87
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot G5EB61 198
organism: Emericella nidulans

CDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot Q8ZYH7 191
organism: Pyrobaculum aerophilum

glutamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P25996 204
type: UnificationXref
id: P25996
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 13

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QNQ2 115
organism: Macaca mulatta

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot O01815 200
organism: Caenorhabditis elegans

Dihydrooratate oxidase
type: ProteinReference
xref: P02927
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Dihydrooratate oxidase Synonym: Synonym not specified Accession: P02927
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine ribonucleotides biosythesis.PROTEIN.GENERIC.Dihydrooratate oxidase
member entity reference: Dihydroorotate dehydrogenase (quinone), mitochondrial
member entity reference: Dihydroorotate dehydrogenase (quinone)
member entity reference: Dihydroorotate dehydrogenase (fumarate)
member entity reference: Dihydroorotate dehydrogenase (PyrD)
member entity reference: Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
member entity reference: Protein CBR-DHOD-1
member entity reference: Uncharacterized protein
member entity reference: Putative dihydroorotate dehydrogenase A (fumarate)

Yarrowia lipolytica
type: BioSource
xref: ncbitaxon 284591 18

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 28

uniprot H2Q705 66
type: UnificationXref
id: H2Q705
db: uniprot

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot Q8IDP8 187
organism: Plasmodium falciparum

uniprot P39207 83
type: UnificationXref
id: P39207
db: uniprot

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot P74587 150
organism: Synechocystis

carbomoyl-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F1ML89 120
type: UnificationXref
id: F1ML89
db: uniprot

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot Q08210 212
organism: Plasmodium falciparum

ncbitaxon 284812 7
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot H2R3J0 257
type: UnificationXref
id: H2R3J0
db: uniprot

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot Q59653 186
organism: Pseudomonas aeruginosa

uniprot O61790 2
type: UnificationXref
id: O61790
db: uniprot

Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
type: ProteinReference
xref: uniprot Q8TT55 219
organism: Methanosarcina acetivorans

uniprot Q8RG85 218
type: UnificationXref
id: Q8RG85
db: uniprot

uniprot Q4GZ95 272
type: UnificationXref
id: Q4GZ95
db: uniprot

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q58509 33
organism: Methanocaldococcus jannaschii

STATE_TRANSITION_LEFT__dihydroorotate-_O2-RIGHT__orotate-_H2O2-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 294
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 296
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 293
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 295
left: dihydroorotate
left: O2
interaction type: STATE_TRANSITION
right: H2O2
right: orotate

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 38

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 188

ncbitaxon 10116 56
type: UnificationXref
id: 10116
db: ncbitaxon

CTP synthase
type: ProteinReference
xref: uniprot Q8ZSY7 280
organism: Pyrobaculum aerophilum

uniprot Q8TKW5 279
type: UnificationXref
id: Q8TKW5
db: uniprot

uniprot Q02127 211
type: UnificationXref
id: Q02127
db: uniprot

uniprot A8WS68 53
type: UnificationXref
id: A8WS68
db: uniprot

carbamoyl-aspartate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q58773 158
type: UnificationXref
id: Q58773
db: uniprot

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot Q8THL2 190
organism: Methanosarcina acetivorans

ncbitaxon 13616 125
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot P74163 181
type: UnificationXref
id: P74163
db: uniprot

uniprot Q7XC37 104
type: UnificationXref
id: Q7XC37
db: uniprot

uniprot P38100 149
type: UnificationXref
id: P38100
db: uniprot

Orotidine 5'-phosphate decarboxylase
type: ProteinReference
xref: uniprot P15188 237
organism: Ustilago maydis

uniprot P17812 263
type: UnificationXref
id: P17812
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot F4I6G9 250
organism: Arabidopsis thaliana

STATE_TRANSITION_LEFT__CTP-_ADP-RIGHT__CDP-_ATP-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 315
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 313
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 312
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 314
left: CTP
left: ADP
interaction type: STATE_TRANSITION
right: CDP
right: ATP

CTP synthase
type: ProteinReference
xref: uniprot H2R3J0 257
organism: Pan troglodytes

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot P38100 149
organism: Pseudomonas aeruginosa

PARTICIPANT STOICHIOMETRY r7 328
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

ncbitaxon 5664 30
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot P15532 74
type: UnificationXref
id: P15532
db: uniprot

Orotidine 5'-phosphate decarboxylase
type: ProteinReference
xref: uniprot Q8TS37 240
organism: Methanosarcina acetivorans

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot Q58976 185
organism: Methanocaldococcus jannaschii

Dihydroorotate dehydrogenase (quinone)
type: ProteinReference
xref: uniprot P74782 209
organism: Synechocystis

ncbitaxon 83332 26
type: UnificationXref
id: 83332
db: ncbitaxon

Orotidine 5'-phosphate decarboxylase
type: ProteinReference
xref: uniprot P10652 233
organism: Emericella nidulans

uniprot O93937 132
type: UnificationXref
id: O93937
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q9U1E1 110
organism: Leishmania major

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q58661 98
organism: Methanocaldococcus jannaschii

uniprot Q7QIX6 102
type: UnificationXref
id: Q7QIX6
db: uniprot

uniprot P9WJH7 89
type: UnificationXref
id: P9WJH7
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 65

ncbitaxon 188937 24
type: UnificationXref
id: 188937
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HA84 61
organism: Macaca mulatta

AGAP004175-PA
type: ProteinReference
xref: uniprot Q7QB57 35
organism: Anopheles gambiae

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 101

uniprot A0A1D5QNQ2 115
type: UnificationXref
id: A0A1D5QNQ2
db: uniprot

ncbitaxon 367110 38
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot O67353 260
type: UnificationXref
id: O67353
db: uniprot

uniprot Q9WZ28 176
type: UnificationXref
id: Q9WZ28
db: uniprot

Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
type: ProteinReference
xref: uniprot D4A8A0 118
organism: Rattus norvegicus

ncbitaxon 185431 96
type: UnificationXref
id: 185431
db: ncbitaxon

uniprot O64753 259
type: UnificationXref
id: O64753
db: uniprot

uniprot K7BSW8 68
type: UnificationXref
id: K7BSW8
db: uniprot

PARTICIPANT STOICHIOMETRY r7 330
type: Stoichiometry
physical entity: UDP
stoichiometric coefficient: 1.0

Carbamoyl-phosphate synthase large chain, N-terminal section
type: ProteinReference
xref: uniprot Q58773 158
organism: Methanocaldococcus jannaschii

PARTICIPANT STOICHIOMETRY r7 331
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot H2Q705 66
organism: Pan troglodytes

Carbamoyl-phosphate synthase large chain, C-terminal section
type: ProteinReference
xref: uniprot Q58776 159
organism: Methanocaldococcus jannaschii

uniprot A0JNE9 242
type: UnificationXref
id: A0JNE9
db: uniprot

CAD protein
type: ProteinReference
xref: uniprot Q18990 154
organism: Caenorhabditis elegans

ncbitaxon 237561 235
type: UnificationXref
id: 237561
db: ncbitaxon

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot A8WS68 53
organism: Caenorhabditis briggsae

uniprot K7C7B9 128
type: UnificationXref
id: K7C7B9
db: uniprot

CPS1 isoform 4
type: ProteinReference
xref: uniprot K7C7B9 128
organism: Pan troglodytes

Orotate phosphoribosyltransferase
type: ProteinReference
xref: P02922
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine ribonucleotides biosythesis.PROTEIN.GENERIC.Orotate_br_phosphoribosyltransferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Orotate phosphoribosyltransferase Synonym: Synonym not specified Accession: P02922
member entity reference: Orotate phosphoribosyltransferase
member entity reference: Uridine 5'-monophosphate synthase
member entity reference: AGAP004175-PA
member entity reference: Orotate phosphoribosyltransferase 2
member entity reference: Putative OMPDCase-OPRTase
member entity reference: Orotate phosphoribosyltransferase 1

ncbitaxon 227321 107
type: UnificationXref
id: 227321
db: ncbitaxon

Uridylate kinase
type: ProteinReference
xref: uniprot O59771 113
organism: Schizosaccharomyces pombe

uniprot O84508 69
type: UnificationXref
id: O84508
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot Q58574 273
organism: Methanocaldococcus jannaschii

PARTICIPANT STOICHIOMETRY r7 329
type: Stoichiometry
physical entity: UMP
stoichiometric coefficient: 1.0

CTP synthase
type: ProteinReference
xref: uniprot G5EC98 256
organism: Caenorhabditis elegans

uniprot A0A1D5R8P4 196
type: UnificationXref
id: A0A1D5R8P4
db: uniprot

UMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
type: ProteinReference
xref: uniprot O49203 228
organism: Arabidopsis thaliana

Orotidine 5'-phosphate decarboxylase
type: ProteinReference
xref: uniprot P03962 232
organism: Saccharomyces cerevisiae

uniprot P0CS95 10
type: UnificationXref
id: P0CS95
db: uniprot

Down syndrome cell adhesion molecule-like protein 1 homolog
type: ProteinReference
xref: uniprot Q4VA61 97
organism: Mus musculus

Carbamoyl-phosphate synthase arginine-specific large chain
type: ProteinReference
xref: uniprot P03965 135
organism: Saccharomyces cerevisiae

Orotate phosphoribosyltransferase
type: Protein
entity reference: Orotate phosphoribosyltransferase
comment: SPECIES_TYPE=PROTEIN

uniprot Q8ZYH7 191
type: UnificationXref
id: Q8ZYH7
db: uniprot

uniprot O94313 133
type: UnificationXref
id: O94313
db: uniprot

uniprot Q9RVC0 195
type: UnificationXref
id: Q9RVC0
db: uniprot

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot A0A1D5R8P4 196
organism: Macaca mulatta

uniprot P03962 232
type: UnificationXref
id: P03962
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P74494 88
organism: Synechocystis

CTP synthase
type: ProteinReference
xref: uniprot E2RU94 248
organism: Giardia intestinalis

ncbitaxon 6239 3
type: UnificationXref
id: 6239
db: ncbitaxon

Down syndrome cell adhesion molecule-like protein 1
type: ProteinReference
xref: uniprot Q8TD84 105
organism: Homo sapiens

CTP synthase 1
type: ProteinReference
xref: uniprot P70698 267
organism: Mus musculus

uniprot Q58425 157
type: UnificationXref
id: Q58425
db: uniprot

STATE_TRANSITION_LEFT__orotidine_5_phosphate-RIGHT__CO2-_UMP-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 333
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 334
left: orotidine-5-phosphate
interaction type: STATE_TRANSITION
right: UMP
right: CO2

ncbitaxon 184922 249
type: UnificationXref
id: 184922
db: ncbitaxon

Nucleoside diphosphate kinase A
type: ProteinReference
xref: uniprot Q05982 91
organism: Rattus norvegicus

uniprot P58859 23
type: UnificationXref
id: P58859
db: uniprot

uniprot P22887 78
type: UnificationXref
id: P22887
db: uniprot

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot O66727 130
organism: Aquifex aeolicus

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot O66726 177
organism: Aquifex aeolicus

uniprot Q8TS37 240
type: UnificationXref
id: Q8TS37
db: uniprot

uniprot Q9RWI4 173
type: UnificationXref
id: Q9RWI4
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot Q8TKW5 279
organism: Methanosarcina acetivorans

Nucleoside diphosphate kinase B
type: ProteinReference
xref: uniprot P19804 76
organism: Rattus norvegicus

uniprot O60060 129
type: UnificationXref
id: O60060
db: uniprot

uniprot Q4QEW5 29
type: UnificationXref
id: Q4QEW5
db: uniprot

HCO3
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P05654 178
type: UnificationXref
id: P05654
db: uniprot

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9HNG2 41
organism: Halobacterium salinarum

uniprot Q63707 215
type: UnificationXref
id: Q63707
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot Q5VPD3 276
organism: Oryza sativa

ncbitaxon 214684 11
type: UnificationXref
id: 214684
db: ncbitaxon

Carbamoyl-phosphate synthase arginine-specific small chain
type: ProteinReference
xref: uniprot O60060 129
organism: Schizosaccharomyces pombe

uniprot P34093 81
type: UnificationXref
id: P34093
db: uniprot

Dihydroorotate dehydrogenase (quinone)
type: ProteinReference
xref: uniprot Q9KXR7 223
organism: Streptomyces coelicolor

uniprot Q58574 273
type: UnificationXref
id: Q58574
db: uniprot

Orotidine-5-phosphate decarboxylase
type: ProteinReference
xref: P02930
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Orotidine-5-phosphate decarboxylase Synonym: Synonym not specified Accession: P02930
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine ribonucleotides biosythesis.PROTEIN.GENERIC.Orotidine-5-phosphate_br_decarboxylase
member entity reference: Orotidine 5'-phosphate decarboxylase

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q9KXR6 171
organism: Streptomyces coelicolor

uniprot P0A7E5 261
type: UnificationXref
id: P0A7E5
db: uniprot

uniprot E2RD29 247
type: UnificationXref
id: E2RD29
db: uniprot

Orotidine 5'-phosphate decarboxylase
type: ProteinReference
xref: uniprot Q57700 239
organism: Methanocaldococcus jannaschii

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot Q9KXR5 170
organism: Streptomyces coelicolor

uniprot P70303 266
type: UnificationXref
id: P70303
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot E2RD29 247
organism: Canis lupus familiaris

ncbitaxon 559292 13
type: UnificationXref
id: 559292
db: ncbitaxon

Carbamoyl-phosphate synthase [ammonia], mitochondrial
type: ProteinReference
xref: uniprot P07756 139
organism: Rattus norvegicus

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot Q9KXR2 193
organism: Streptomyces coelicolor

uniprot P13298 12
type: UnificationXref
id: P13298
db: uniprot

uniprot B1WC02 243
type: UnificationXref
id: B1WC02
db: uniprot

Dihydroorotate dehydrogenase (quinone)
type: ProteinReference
xref: uniprot Q9RX14 224
organism: Deinococcus radiodurans

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot F6TWB9 59
organism: Ornithorhynchus anatinus

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q55574 31
organism: Synechocystis

UDP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q4QEW6 184
type: UnificationXref
id: Q4QEW6
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot G3V816 63
organism: Rattus norvegicus

uniprot P70698 267
type: UnificationXref
id: P70698
db: uniprot

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 15

Protein ura1
type: ProteinReference
xref: uniprot Q09794 153
organism: Schizosaccharomyces pombe

Bos taurus
type: BioSource
xref: ncbitaxon 9913 52

uniprot P05990 136
type: UnificationXref
id: P05990
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 62

Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
type: ProteinReference
xref: uniprot Q58070 214
organism: Methanocaldococcus jannaschii

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P08879 71
organism: Drosophila melanogaster

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 60

uniprot Q8RG89 189
type: UnificationXref
id: Q8RG89
db: uniprot

uniprot P50587 19
type: UnificationXref
id: P50587
db: uniprot

O2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q8TFN0 106
organism: Emericella nidulans

uniprot Q9KXR7 223
type: UnificationXref
id: Q9KXR7
db: uniprot

PANTHER Pathway P02740 1
type: UnificationXref
id: P02740
db: PANTHER Pathway

uniprot Q1RMS2 271
type: UnificationXref
id: Q1RMS2
db: uniprot

Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
type: ProteinReference
xref: uniprot F7E0R2 124
organism: Monodelphis domestica

uniprot P25994 144
type: UnificationXref
id: P25994
db: uniprot

uniprot P58856 21
type: UnificationXref
id: P58856
db: uniprot

Carbamoyl-phosphate synthase [ammonia], mitochondrial
type: ProteinReference
xref: uniprot P31327 146
organism: Homo sapiens

Nucleoside diphosphate kinase 1
type: ProteinReference
xref: uniprot Q07661 92
organism: Oryza sativa

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 24

uniprot Q55574 31
type: UnificationXref
id: Q55574
db: uniprot

uniprot Q8TD84 105
type: UnificationXref
id: Q8TD84
db: uniprot

uniprot P0A7E1 203
type: UnificationXref
id: P0A7E1
db: uniprot

Nucleoside diphosphate kinase B
type: ProteinReference
xref: uniprot Q01768 90
organism: Mus musculus

uniprot O67742 4
type: UnificationXref
id: O67742
db: uniprot

uniprot P32746 206
type: UnificationXref
id: P32746
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P61136 87
organism: Halobacterium salinarum

uniprot Q7Q1U7 277
type: UnificationXref
id: Q7Q1U7
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 245

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P9WJH7 89
organism: Mycobacterium tuberculosis

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q8TQL6 108
organism: Methanosarcina acetivorans

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q8ZY48 166
organism: Pyrobaculum aerophilum

uniprot P19804 76
type: UnificationXref
id: P19804
db: uniprot

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot Q8ZY49 167
organism: Pyrobaculum aerophilum

uniprot P13242 262
type: UnificationXref
id: P13242
db: uniprot

uniprot P15531 72
type: UnificationXref
id: P15531
db: uniprot

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 5

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot P0CS95 10
organism: Cryptococcus neoformans

Uridine 5'-monophosphate synthase
type: ProteinReference
xref: uniprot Q01637 27
organism: Drosophila melanogaster

CTP synthase (Fragment)
type: ProteinReference
xref: uniprot Q7Q1U7 277
organism: Anopheles gambiae

uniprot H2Q4V0 64
type: UnificationXref
id: H2Q4V0
db: uniprot

uniprot O94331 6
type: UnificationXref
id: O94331
db: uniprot

uniprot P00968 134
type: UnificationXref
id: P00968
db: uniprot

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot Q02127 211
organism: Homo sapiens

uniprot Q7RVF7 37
type: UnificationXref
id: Q7RVF7
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 58

CDP kinase
type: Protein
entity reference: CDP kinase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9606 73
type: UnificationXref
id: 9606
db: ncbitaxon

2 ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7B8D5 123
type: UnificationXref
id: F7B8D5
db: uniprot

Aspartate carbamoyltransferase, chloroplastic
type: ProteinReference
xref: uniprot Q9LD61 194
organism: Oryza sativa

uniprot Q9HP42 168
type: UnificationXref
id: Q9HP42
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_UDP-RIGHT__UTP-_ADP-_r8
controller: UDP kinase

ncbitaxon 7165 36
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot O66727 130
type: UnificationXref
id: O66727
db: uniprot

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot P38098 148
organism: Pseudomonas aeruginosa

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q55756 156
organism: Synechocystis

CTP synthase
type: ProteinReference
xref: uniprot P13242 262
organism: Bacillus subtilis

uniprot Q8ZTG3 39
type: UnificationXref
id: Q8ZTG3
db: uniprot

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot P00968 134
organism: Escherichia coli

uniprot Q9HXZ4 282
type: UnificationXref
id: Q9HXZ4
db: uniprot

H2O2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q08210 212
type: UnificationXref
id: Q08210
db: uniprot

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 40

uniprot O66461 202
type: UnificationXref
id: O66461
db: uniprot

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q7RVF7 37
organism: Neurospora crassa

uniprot Q9WZR0 288
type: UnificationXref
id: Q9WZR0
db: uniprot

uniprot P07259 138
type: UnificationXref
id: P07259
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 48

CTP synthase 2
type: ProteinReference
xref: uniprot Q9NRF8 284
organism: Homo sapiens

uniprot Q9LTW8 283
type: UnificationXref
id: Q9LTW8
db: uniprot

ncbitaxon 9544 62
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot P49077 180
type: UnificationXref
id: P49077
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot Q0WRY1 270
organism: Arabidopsis thaliana

ncbitaxon 7955 50
type: UnificationXref
id: 7955
db: ncbitaxon

CTP synthase
type: ProteinReference
xref: uniprot Q9RU23 285
organism: Deinococcus radiodurans

uniprot F1MVC0 121
type: UnificationXref
id: F1MVC0
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q8RG86 162
type: UnificationXref
id: Q8RG86
db: uniprot

CTP synthase 2
type: ProteinReference
xref: uniprot Q1RMS2 271
organism: Bos taurus

uniprot Q8C196 161
type: UnificationXref
id: Q8C196
db: uniprot

PARTICIPANT STOICHIOMETRY r3 298
type: Stoichiometry
physical entity: dihydroorotate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 297
type: Stoichiometry
physical entity: carbamoyl-aspartate
stoichiometric coefficient: 1.0

CTP synthase
type: ProteinReference
xref: uniprot Q9HXZ4 282
organism: Pseudomonas aeruginosa

aspartate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r3 299
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

uniprot Q9WZ27 175
type: UnificationXref
id: Q9WZ27
db: uniprot

uniprot Q59321 274
type: UnificationXref
id: Q59321
db: uniprot

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot H2QBH6 199
organism: Pan troglodytes

uniprot P13649 234
type: UnificationXref
id: P13649
db: uniprot

uniprot Q8THL2 190
type: UnificationXref
id: Q8THL2
db: uniprot

uniprot Q9KXR6 171
type: UnificationXref
id: Q9KXR6
db: uniprot

uniprot P50589 86
type: UnificationXref
id: P50589
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot O67353 260
organism: Aquifex aeolicus

uniprot E2RU94 248
type: UnificationXref
id: E2RU94
db: uniprot

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9RX68 43
organism: Deinococcus radiodurans

uniprot F1PJF3 122
type: UnificationXref
id: F1PJF3
db: uniprot

uniprot Q8ZY48 166
type: UnificationXref
id: Q8ZY48
db: uniprot

dihydroorotate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aspartate carbamoyltransferase catalytic subunit
type: ProteinReference
xref: uniprot P0A786 179
organism: Escherichia coli

CTP synthase
type: ProteinReference
xref: uniprot O64753 259
organism: Arabidopsis thaliana

Carbamoyl-phosphate synthase [ammonia], mitochondrial
type: ProteinReference
xref: uniprot Q8C196 161
organism: Mus musculus

Dihydrooratase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot Q42601 155
type: UnificationXref
id: Q42601
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot Q9LTW8 283
organism: Arabidopsis thaliana

P02930
type: UnificationXref
id: P02930
db: PANTHER Pathway Component

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 54

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CTP-_ADP-RIGHT__CDP-_ATP-_r10
controller: CDP kinase

P02931
type: UnificationXref
id: P02931
db: PANTHER Pathway Component

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P49740 85
organism: Schizosaccharomyces pombe

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 3

CTP synthase 2
type: ProteinReference
xref: uniprot P70303 266
organism: Mus musculus

DS cell adhesion molecule like 1
type: ProteinReference
xref: uniprot H2Q4V0 64
organism: Pan troglodytes

Carbamoyl-phosphate synthase small chain, chloroplastic
type: ProteinReference
xref: uniprot Q9LVW7 172
organism: Arabidopsis thaliana

CTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot O01815 200
type: UnificationXref
id: O01815
db: uniprot

uniprot Q9HZF8 222
type: UnificationXref
id: Q9HZF8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_UMP-RIGHT__UDP-_ADP-_r7
controller: Uridylate kinase

ncbitaxon 272561 70
type: UnificationXref
id: 272561
db: ncbitaxon

uniprot A0A2I3TBT7 116
type: UnificationXref
id: A0A2I3TBT7
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot A0A0R4IS05 49
organism: Danio rerio

uniprot J9P3S5 67
type: UnificationXref
id: J9P3S5
db: uniprot

uniprot P08879 71
type: UnificationXref
id: P08879
db: uniprot

Protein PyrBI
type: ProteinReference
xref: uniprot P96111 182
organism: Thermotoga maritima

UDP kinase
type: ProteinReference
xref: P02923
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine ribonucleotides biosythesis.PROTEIN.GENERIC.UDP kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: UDP kinase Synonym: Synonym not specified Accession: P02923
member entity reference: Nucleoside diphosphate kinase
member entity reference: Nucleoside diphosphate kinase 1
member entity reference: Nucleoside diphosphate kinase B
member entity reference: DS cell adhesion molecule like 1
member entity reference: DS cell adhesion molecule-like 1
member entity reference: Uncharacterized protein
member entity reference: Nucleoside diphosphate kinase A
member entity reference: Down syndrome cell adhesion molecule-like protein 1
member entity reference: Nucleoside diphosphate kinase 3
member entity reference: Nucleoside diphosphate kinase, mitochondrial
member entity reference: Down syndrome cell adhesion molecule-like protein 1 homolog
member entity reference: Nucleoside diphosphate kinase, cytosolic

ncbitaxon 6238 54
type: UnificationXref
id: 6238
db: ncbitaxon

P02922
type: UnificationXref
id: P02922
db: PANTHER Pathway Component

Carbamoyl-phosphate synthase large chain, C-terminal section
type: ProteinReference
xref: uniprot O67233 131
organism: Aquifex aeolicus

uniprot P14965 236
type: UnificationXref
id: P14965
db: uniprot

uniprot Q9WV84 231
type: UnificationXref
id: Q9WV84
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 93

P02925
type: UnificationXref
id: P02925
db: PANTHER Pathway Component

P02926
type: UnificationXref
id: P02926
db: PANTHER Pathway Component

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 20

P02923
type: UnificationXref
id: P02923
db: PANTHER Pathway Component

uniprot Q8ZY49 167
type: UnificationXref
id: Q8ZY49
db: uniprot

P02924
type: UnificationXref
id: P02924
db: PANTHER Pathway Component

P02929
type: UnificationXref
id: P02929
db: PANTHER Pathway Component

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dihydroorotate-_O2-RIGHT__orotate-_H2O2-_r4
controller: Dihydrooratate oxidase

P02927
type: UnificationXref
id: P02927
db: PANTHER Pathway Component

CTP synthase
type: ProteinReference
xref: uniprot Q9VUL1 287
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__aspartate-_carbomoyl_phosphate-RIGHT__carbamoyl_aspartate-_PO4-_r2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 300
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 303
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 301
participant stoichiometry: PARTICIPANT STOICHIOMETRY r2 302
left: carbomoyl-phosphate
left: aspartate
interaction type: STATE_TRANSITION
right: PO4
right: carbamoyl-aspartate

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot Q7XKC8 217
organism: Oryza sativa

uniprot Q9LVW7 172
type: UnificationXref
id: Q9LVW7
db: uniprot

uniprot P0A6F1 140
type: UnificationXref
id: P0A6F1
db: uniprot

uniprot P9WHK7 269
type: UnificationXref
id: P9WHK7
db: uniprot

uniprot O49203 228
type: UnificationXref
id: O49203
db: uniprot

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot O61790 2
organism: Caenorhabditis elegans

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 42

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9WYG6 45
organism: Thermotoga maritima

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q93576 109
organism: Caenorhabditis elegans

STATE_TRANSITION_LEFT__ATP-_UMP-RIGHT__UDP-_ADP-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 329
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 330
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 328
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 331
left: ATP
left: UMP
interaction type: STATE_TRANSITION
right: UDP
right: ADP

Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
type: ProteinReference
xref: uniprot Q9WYG8 225
organism: Thermotoga maritima

ncbitaxon 284591 18
type: UnificationXref
id: 284591
db: ncbitaxon

uniprot P07756 139
type: UnificationXref
id: P07756
db: uniprot

ncbitaxon 8364 101
type: UnificationXref
id: 8364
db: ncbitaxon

ncbitaxon 9615 58
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot Q381H3 95
type: UnificationXref
id: Q381H3
db: uniprot

orotate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 36

PPi
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 11

uniprot Q13232 94
type: UnificationXref
id: Q13232
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__HCO3-_2_ATP-_H2O-_glutamine-RIGHT__2_ADP-_glutamate-_carbomoyl_phosphate-_PO4-_r1
controller: Carbamoyl phosphate synthetase

uniprot Q9U1E1 110
type: UnificationXref
id: Q9U1E1
db: uniprot

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot Q9RWI4 173
organism: Deinococcus radiodurans

uniprot F6QMZ6 251
type: UnificationXref
id: F6QMZ6
db: uniprot

uniprot P9WHL1 210
type: UnificationXref
id: P9WHL1
db: uniprot

uniprot P9WPK3 151
type: UnificationXref
id: P9WPK3
db: uniprot

uniprot P41923 17
type: UnificationXref
id: P41923
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot A0JNE9 242
organism: Bos taurus

Aspartate carbamoyltransferase
type: Protein
entity reference: Aspartate carbamoyltransferase
comment: SPECIES_TYPE=PROTEIN

Putative dihydroorotate dehydrogenase A (fumarate)
type: ProteinReference
xref: uniprot O66461 202
organism: Aquifex aeolicus

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 70

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 46

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot P9WIT7 183
organism: Mycobacterium tuberculosis

Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
type: ProteinReference
xref: uniprot Q8RG85 218
organism: Fusobacterium nucleatum

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q8RG86 162
organism: Fusobacterium nucleatum

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot Q8RG89 189
organism: Fusobacterium nucleatum

CTP synthase
type: ProteinReference
xref: uniprot O42644 258
organism: Schizosaccharomyces pombe

uniprot O35435 201
type: UnificationXref
id: O35435
db: uniprot

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot Q8RG87 163
organism: Fusobacterium nucleatum

uniprot Q58776 159
type: UnificationXref
id: Q58776
db: uniprot

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot P32747 207
organism: Schizosaccharomyces pombe

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot P32748 208
organism: Drosophila melanogaster

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 32

PARTICIPANT STOICHIOMETRY r10 315
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 314
type: Stoichiometry
physical entity: CDP
stoichiometric coefficient: 1.0

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot P32746 206
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r10 313
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q9RWK0 174
type: UnificationXref
id: Q9RWK0
db: uniprot

PARTICIPANT STOICHIOMETRY r10 312
type: Stoichiometry
physical entity: CTP
stoichiometric coefficient: 1.0

CTP synthase
type: ProteinReference
xref: uniprot F6QMZ6 251
organism: Xenopus tropicalis

CTP synthase
type: ProteinReference
xref: uniprot B1WC02 243
organism: Rattus norvegicus

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot Q8TNY3 164
organism: Methanosarcina acetivorans

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q8TNY4 165
organism: Methanosarcina acetivorans

ncbitaxon 208964 20
type: UnificationXref
id: 208964
db: ncbitaxon

Protein pyrABCN
type: ProteinReference
xref: uniprot O93937 132
organism: Emericella nidulans

uniprot O42644 258
type: UnificationXref
id: O42644
db: uniprot

PRPP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__carbamoyl_aspartate-RIGHT__dihydroorotate-_H2O-_r3
controller: Dihydrooratase

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_H2O-_UTP-_glutamine-RIGHT__glutamate-_CTP-_PO4-_ADP-_r9
controller: CTP synthase

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot O67742 4
organism: Aquifex aeolicus

uniprot P38627 265
type: UnificationXref
id: P38627
db: uniprot

ncbitaxon 9258 60
type: UnificationXref
id: 9258
db: ncbitaxon

CAD protein
type: ProteinReference
xref: uniprot P05990 136
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RAV2 119
organism: Canis lupus familiaris

Carbamoyl phosphate synthetase
type: Protein
entity reference: Carbamoyl phosphate synthetase
comment: SPECIES_TYPE=PROTEIN

CTP synthase
type: ProteinReference
xref: P02931
comment: ENTITY_REFERENCE_NOTES=Long Name: CTP synthase Synonym: Synonym not specified Accession: P02931
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine ribonucleotides biosythesis.PROTEIN.GENERIC.CTP synthase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: CTP synthase
member entity reference: CTP synthase 2
member entity reference: CTP synthase 1
member entity reference: CTP synthase (Fragment)

uniprot Q09794 153
type: UnificationXref
id: Q09794
db: uniprot

ncbitaxon 6945 245
type: UnificationXref
id: 6945
db: ncbitaxon

uniprot Q9RX14 224
type: UnificationXref
id: Q9RX14
db: uniprot

Nucleoside diphosphate kinase A
type: ProteinReference
xref: uniprot P15532 74
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PEK4 57
organism: Canis lupus familiaris

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 125

uniprot G5EB61 198
type: UnificationXref
id: G5EB61
db: uniprot

Nucleoside diphosphate kinase A
type: ProteinReference
xref: uniprot P15531 72
organism: Homo sapiens

Orotidine 5'-phosphate decarboxylase
type: ProteinReference
xref: uniprot P14965 236
organism: Schizosaccharomyces pombe

UTP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q58661 98
type: UnificationXref
id: Q58661
db: uniprot

CAD protein
type: ProteinReference
xref: uniprot P27708 145
organism: Homo sapiens

uniprot P36010 82
type: UnificationXref
id: P36010
db: uniprot

ncbitaxon 44689 79
type: UnificationXref
id: 44689
db: ncbitaxon

uniprot P28274 264
type: UnificationXref
id: P28274
db: uniprot

uniprot F7HA84 61
type: UnificationXref
id: F7HA84
db: uniprot

uniprot Q9HNG2 41
type: UnificationXref
id: Q9HNG2
db: uniprot

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot Q9HHN4 192
organism: Halobacterium salinarum

PARTICIPANT STOICHIOMETRY r1 305
type: Stoichiometry
physical entity: 2 ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 306
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 307
type: Stoichiometry
physical entity: glutamine
stoichiometric coefficient: 1.0

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 7

PARTICIPANT STOICHIOMETRY r1 308
type: Stoichiometry
physical entity: 2 ADP
stoichiometric coefficient: 1.0

ncbitaxon 64091 42
type: UnificationXref
id: 64091
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r1 309
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

uniprot Q9WYG6 45
type: UnificationXref
id: Q9WYG6
db: uniprot

uniprot Q18990 154
type: UnificationXref
id: Q18990
db: uniprot

De novo pyrimidine ribonucleotides biosythesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__CTP-_ADP-RIGHT__CDP-_ATP-_r10
pathway component: STATE_TRANSITION_LEFT__dihydroorotate-_O2-RIGHT__orotate-_H2O2-_r4
pathway component: STATE_TRANSITION_LEFT__ATP-_UMP-RIGHT__UDP-_ADP-_r7
pathway component: STATE_TRANSITION_LEFT__carbamoyl_aspartate-RIGHT__dihydroorotate-_H2O-_r3
pathway component: STATE_TRANSITION_LEFT__ATP-_UDP-RIGHT__UTP-_ADP-_r8
pathway component: STATE_TRANSITION_LEFT__orotate-_PRPP-RIGHT__orotidine_5_phosphate-_PPi-_r5
pathway component: STATE_TRANSITION_LEFT__HCO3-_2_ATP-_H2O-_glutamine-RIGHT__2_ADP-_glutamate-_carbomoyl_phosphate-_PO4-_r1
pathway component: STATE_TRANSITION_LEFT__orotidine_5_phosphate-RIGHT__CO2-_UMP-_r6
pathway component: STATE_TRANSITION_LEFT__ATP-_H2O-_UTP-_glutamine-RIGHT__glutamate-_CTP-_PO4-_ADP-_r9
pathway component: STATE_TRANSITION_LEFT__aspartate-_carbomoyl_phosphate-RIGHT__carbamoyl_aspartate-_PO4-_r2
xref: PANTHER Pathway P02740 1
comment: MODEL_NOTES=The de novo biosynthesis of pyrimidine ribonucleotides, the monomeric units of RNA. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

CDP kinase
type: ProteinReference
xref: P02929
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: CDP kinase Synonym: Synonym not specified Accession: P02929
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine ribonucleotides biosythesis.PROTEIN.GENERIC.CDP kinase
member entity reference: Nucleoside diphosphate kinase
member entity reference: Nucleoside diphosphate kinase 1
member entity reference: Nucleoside diphosphate kinase B
member entity reference: Uncharacterized protein
member entity reference: Nucleoside diphosphate kinase, mitochondrial
member entity reference: Nucleoside diphosphate kinase III, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase A
member entity reference: Nucleoside diphosphate kinase 3
member entity reference: Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
member entity reference: Nucleoside diphosphate kinase II, chloroplastic
member entity reference: Nucleoside diphosphate kinase, cytosolic

Aspartate carbamoyltransferase
type: ProteinReference
xref: P02926
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine ribonucleotides biosythesis.PROTEIN.GENERIC.Aspartate_br_carbamoyltransferase
comment: ENTITY_REFERENCE_NOTES=Long Name: Aspartate carbamoyltransferase Synonym: Synonym not specified Accession: P02926
member entity reference: Aspartate carbamoyltransferase
member entity reference: Aspartate carbamoyltransferase catalytic subunit
member entity reference: Putative aspartate carbamoyltransferase
member entity reference: Aspartate carbamoyltransferase, chloroplastic
member entity reference: Protein PyrBI

PARTICIPANT STOICHIOMETRY r9 317
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 316
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 319
type: Stoichiometry
physical entity: glutamine
stoichiometric coefficient: 1.0

uniprot Q4QEW7 213
type: UnificationXref
id: Q4QEW7
db: uniprot

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot P58856 21
organism: Fusobacterium nucleatum

PARTICIPANT STOICHIOMETRY r9 318
type: Stoichiometry
physical entity: UTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 304
type: Stoichiometry
physical entity: HCO3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 323
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

Carbamoyl-phosphate synthase arginine-specific small chain, mitochondrial
type: ProteinReference
xref: uniprot P22572 142
organism: Neurospora crassa

uniprot Q8ZSY7 280
type: UnificationXref
id: Q8ZSY7
db: uniprot

uniprot F6TWB9 59
type: UnificationXref
id: F6TWB9
db: uniprot

PARTICIPANT STOICHIOMETRY r9 320
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 321
type: Stoichiometry
physical entity: CTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 322
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

uniprot Q7XKC8 217
type: UnificationXref
id: Q7XKC8
db: uniprot

uniprot Q01768 90
type: UnificationXref
id: Q01768
db: uniprot

ncbitaxon 9598 65
type: UnificationXref
id: 9598
db: ncbitaxon

CTP synthase 2
type: ProteinReference
xref: uniprot P38627 265
organism: Saccharomyces cerevisiae

uniprot P22572 142
type: UnificationXref
id: P22572
db: uniprot

Orotate phosphoribosyltransferase 1
type: ProteinReference
xref: uniprot P13298 12
organism: Saccharomyces cerevisiae

STATE_TRANSITION_LEFT__HCO3-_2_ATP-_H2O-_glutamine-RIGHT__2_ADP-_glutamate-_carbomoyl_phosphate-_PO4-_r1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 310
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 306
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 309
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 308
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 305
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 304
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 311
participant stoichiometry: PARTICIPANT STOICHIOMETRY r1 307
left: 2 ATP
left: HCO3
left: H2O
left: glutamine
interaction type: STATE_TRANSITION
right: PO4
right: 2 ADP
right: carbomoyl-phosphate
right: glutamate

CTP synthase
type: ProteinReference
xref: uniprot P74208 268
organism: Synechocystis

uniprot Q59653 186
type: UnificationXref
id: Q59653
db: uniprot

uniprot Q8ILZ3 278
type: UnificationXref
id: Q8ILZ3
db: uniprot

uniprot Q8IDP8 187
type: UnificationXref
id: Q8IDP8
db: uniprot

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot O35435 201
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r1 310
type: Stoichiometry
physical entity: carbomoyl-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r1 311
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

ncbitaxon 178306 40
type: UnificationXref
id: 178306
db: ncbitaxon

Uridylate kinase
type: ProteinReference
xref: uniprot P15700 114
organism: Saccharomyces cerevisiae

uniprot P9WPK5 152
type: UnificationXref
id: P9WPK5
db: uniprot

uniprot O64903 229
type: UnificationXref
id: O64903
db: uniprot

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot P58859 23
organism: Methanosarcina acetivorans

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot O84508 69
organism: Chlamydia trachomatis

uniprot Q9WV85 112
type: UnificationXref
id: Q9WV85
db: uniprot

uniprot E2QUQ3 246
type: UnificationXref
id: E2QUQ3
db: uniprot

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 44

uniprot F4I6G9 250
type: UnificationXref
id: F4I6G9
db: uniprot

ncbitaxon 243232 34
type: UnificationXref
id: 243232
db: ncbitaxon

Dihydroorotate dehydrogenase (PyrD)
type: ProteinReference
xref: uniprot Q8ZTG4 220
organism: Pyrobaculum aerophilum

uniprot Q9X8R7 47
type: UnificationXref
id: Q9X8R7
db: uniprot

uniprot P31327 146
type: UnificationXref
id: P31327
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 73

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q8ZTG3 39
organism: Pyrobaculum aerophilum

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2I3TBT7 116
organism: Pan troglodytes

Methanocaldococcus jannaschii
type: BioSource
xref: ncbitaxon 243232 34

PARTICIPANT STOICHIOMETRY r6 332
type: Stoichiometry
physical entity: orotidine-5-phosphate
stoichiometric coefficient: 1.0

uniprot Q9HMK2 221
type: UnificationXref
id: Q9HMK2
db: uniprot

uniprot P9WIT7 183
type: UnificationXref
id: P9WIT7
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P31103 80
organism: Bacillus subtilis

uniprot Q7QF47 160
type: UnificationXref
id: Q7QF47
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot F7CDE0 226
organism: Macaca mulatta

uniprot Q9KXR5 170
type: UnificationXref
id: Q9KXR5
db: uniprot

uniprot Q6AZK9 100
type: UnificationXref
id: Q6AZK9
db: uniprot

uniprot Q07661 92
type: UnificationXref
id: Q07661
db: uniprot

PARTICIPANT STOICHIOMETRY r6 334
type: Stoichiometry
physical entity: UMP
stoichiometric coefficient: 1.0

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 84

PARTICIPANT STOICHIOMETRY r6 333
type: Stoichiometry
physical entity: CO2
stoichiometric coefficient: 1.0

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q9RWK0 174
organism: Deinococcus radiodurans

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__orotidine_5_phosphate-RIGHT__CO2-_UMP-_r6
controller: Orotidine-5-phosphate decarboxylase

Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial
type: ProteinReference
xref: uniprot Q8LAH8 230
organism: Arabidopsis thaliana

uniprot F7CL99 254
type: UnificationXref
id: F7CL99
db: uniprot

UDP kinase
type: Protein
entity reference: UDP kinase
comment: SPECIES_TYPE=PROTEIN

Protein CBR-DHOD-1
type: ProteinReference
xref: uniprot A8WW30 197
organism: Caenorhabditis briggsae

uniprot P25972 14
type: UnificationXref
id: P25972
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q7QIX6 102
organism: Anopheles gambiae

STATE_TRANSITION_LEFT__ATP-_UDP-RIGHT__UTP-_ADP-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 325
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 324
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 327
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 326
left: UDP
left: ATP
interaction type: STATE_TRANSITION
right: UTP
right: ADP

Carbamoyl-phosphate synthase arginine-specific large chain
type: ProteinReference
xref: uniprot P18185 141
organism: Bacillus subtilis

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot P05654 178
organism: Bacillus subtilis

PARTICIPANT STOICHIOMETRY r2 301
type: Stoichiometry
physical entity: carbomoyl-phosphate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r2 300
type: Stoichiometry
physical entity: aspartate
stoichiometric coefficient: 1.0

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 26

PARTICIPANT STOICHIOMETRY r2 303
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

uniprot Q9HHN4 192
type: UnificationXref
id: Q9HHN4
db: uniprot

PARTICIPANT STOICHIOMETRY r2 302
type: Stoichiometry
physical entity: carbamoyl-aspartate
stoichiometric coefficient: 1.0

uniprot P27708 145
type: UnificationXref
id: P27708
db: uniprot

uniprot P74587 150
type: UnificationXref
id: P74587
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__aspartate-_carbomoyl_phosphate-RIGHT__carbamoyl_aspartate-_PO4-_r2
controller: Aspartate carbamoyltransferase

uniprot P22392 77
type: UnificationXref
id: P22392
db: uniprot

uniprot P32747 207
type: UnificationXref
id: P32747
db: uniprot

uniprot A5PK70 51
type: UnificationXref
id: A5PK70
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 50

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 9

Nucleoside diphosphate kinase 3
type: ProteinReference
xref: uniprot Q13232 94
organism: Homo sapiens

uniprot F1PEK4 57
type: UnificationXref
id: F1PEK4
db: uniprot

Nucleoside diphosphate kinase, mitochondrial
type: ProteinReference
xref: uniprot Q9WV84 231
organism: Mus musculus

Nucleoside diphosphate kinase 3
type: ProteinReference
xref: uniprot Q9WV85 112
organism: Mus musculus

orotidine-5-phosphate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 3702 84
type: UnificationXref
id: 3702
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r8 324
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

uniprot Q8TQL6 108
type: UnificationXref
id: Q8TQL6
db: uniprot

PARTICIPANT STOICHIOMETRY r8 325
type: Stoichiometry
physical entity: UDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 326
type: Stoichiometry
physical entity: UTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r8 327
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

CTP synthase
type: ProteinReference
xref: uniprot Q8ILZ3 278
organism: Plasmodium falciparum

Dihydrooratate oxidase
type: Protein
entity reference: Dihydrooratate oxidase
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 10090 75
type: UnificationXref
id: 10090
db: ncbitaxon

Nucleoside diphosphate kinase, mitochondrial
type: ProteinReference
xref: uniprot O00746 227
organism: Homo sapiens

Carbamoyl-phosphate synthase 1
type: ProteinReference
xref: uniprot F1PJF3 122
organism: Canis lupus familiaris

uniprot E2RAV2 119
type: UnificationXref
id: E2RAV2
db: uniprot

uniprot F7E0R2 124
type: UnificationXref
id: F7E0R2
db: uniprot

uniprot Q9RU23 285
type: UnificationXref
id: Q9RU23
db: uniprot

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q9HP43 169
organism: Halobacterium salinarum

ncbitaxon 36329 188
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot Q8TFN0 106
type: UnificationXref
id: Q8TFN0
db: uniprot

Carbamoyl-phosphate synthase large chain, chloroplastic
type: ProteinReference
xref: uniprot Q42601 155
organism: Arabidopsis thaliana

Dihydroorotate dehydrogenase (quinone)
type: ProteinReference
xref: uniprot Q9HZF8 222
organism: Pseudomonas aeruginosa

ncbitaxon 39947 93
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot P10652 233
type: UnificationXref
id: P10652
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q9UUY8 111
organism: Neurospora crassa

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9HP43 169
type: UnificationXref
id: Q9HP43
db: uniprot

CAD protein
type: ProteinReference
xref: uniprot B2RQC6 117
organism: Mus musculus

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot Q9HP42 168
organism: Halobacterium salinarum

CTP synthase
type: Protein
entity reference: CTP synthase
comment: SPECIES_TYPE=PROTEIN

uniprot Q5VPD3 276
type: UnificationXref
id: Q5VPD3
db: uniprot

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 238

Carbamoyl-phosphate synthase arginine-specific large chain
type: ProteinReference
xref: uniprot O94313 133
organism: Schizosaccharomyces pombe

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MVC0 121
organism: Bos taurus

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot Q63707 215
organism: Rattus norvegicus

AGAP000300-PA
type: ProteinReference
xref: uniprot Q7QF47 160
organism: Anopheles gambiae

CTP synthase
type: ProteinReference
xref: uniprot Q59321 274
organism: Chlamydia trachomatis

CO2
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q7QB57 35
type: UnificationXref
id: Q7QB57
db: uniprot

uniprot P15188 237
type: UnificationXref
id: P15188
db: uniprot

Dihydroorotate dehydrogenase (quinone)
type: ProteinReference
xref: uniprot Q9HMK2 221
organism: Halobacterium salinarum

CTP synthase
type: ProteinReference
xref: uniprot Q9HP32 281
organism: Halobacterium salinarum

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 22

uniprot B7P674 244
type: UnificationXref
id: B7P674
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7B8D5 123
organism: Macaca mulatta

Dihydroorotate dehydrogenase (fumarate)
type: ProteinReference
xref: uniprot Q4QEW7 213
organism: Leishmania major

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 79

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q6AZK9 100
organism: Xenopus tropicalis

Uridylate kinase
type: Protein
entity reference: Uridylate kinase
comment: SPECIES_TYPE=PROTEIN

uniprot Q58070 214
type: UnificationXref
id: Q58070
db: uniprot

uniprot Q9VUL1 287
type: UnificationXref
id: Q9VUL1
db: uniprot

uniprot P74208 268
type: UnificationXref
id: P74208
db: uniprot

uniprot P74782 209
type: UnificationXref
id: P74782
db: uniprot

uniprot D4A8A0 118
type: UnificationXref
id: D4A8A0
db: uniprot

Putative OMPDCase-OPRTase
type: ProteinReference
xref: uniprot Q4QEW5 29
organism: Leishmania major

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 96

Putative aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot Q4QEW6 184
organism: Leishmania major

uniprot P25993 143
type: UnificationXref
id: P25993
db: uniprot

uniprot Q57700 239
type: UnificationXref
id: Q57700
db: uniprot

uniprot P96111 182
type: UnificationXref
id: P96111
db: uniprot

uniprot Q7SXL4 103
type: UnificationXref
id: Q7SXL4
db: uniprot

Orotidine 5'-phosphate decarboxylase
type: ProteinReference
xref: uniprot P13649 234
organism: Candida albicans

ncbitaxon 1111708 32
type: UnificationXref
id: 1111708
db: ncbitaxon

uniprot O67233 131
type: UnificationXref
id: O67233
db: uniprot

uniprot Q8ZTG4 220
type: UnificationXref
id: Q8ZTG4
db: uniprot

CTP synthase 2
type: ProteinReference
xref: uniprot Q5U2N0 275
organism: Rattus norvegicus

Nucleoside diphosphate kinase II, chloroplastic
type: ProteinReference
xref: uniprot O64903 229
organism: Arabidopsis thaliana

uniprot P30402 16
type: UnificationXref
id: P30402
db: uniprot

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot Q9WZ27 175
organism: Thermotoga maritima

Carbamoyl phosphate synthetase
type: ProteinReference
xref: P02925
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Carbamoyl phosphate synthetase Synonym: Synonym not specified Accession: P02925
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine ribonucleotides biosythesis.PROTEIN.GENERIC.Carbamoyl_br_phosphate_br_synthetase
member entity reference: Protein URA2
member entity reference: Carbamoyl-phosphate synthase small chain
member entity reference: Carbamoyl-phosphate synthase [ammonia], mitochondrial
member entity reference: Carbamoyl-phosphate synthase small chain, chloroplastic
member entity reference: Carbamoyl-phosphate synthase large chain, chloroplastic
member entity reference: Protein pyrABCN
member entity reference: Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
member entity reference: Uncharacterized protein
member entity reference: Carbamoyl-phosphate synthase large chain
member entity reference: Carbamoyl-phosphate synthase arginine-specific large chain
member entity reference: CPS1 isoform 4
member entity reference: Carbamoyl-phosphate synthase large chain, N-terminal section
member entity reference: Protein ura1
member entity reference: CAD protein
member entity reference: Carbamoyl-phosphate synthase 1
member entity reference: AGAP000300-PA
member entity reference: Carbamoyl-phosphate synthase large chain, C-terminal section
member entity reference: Carbamoyl-phosphate synthase arginine-specific small chain, mitochondrial
member entity reference: Carbamoyl-phosphate synthase pyrimidine-specific large chain
member entity reference: Carbamoyl-phosphate synthase arginine-specific small chain
member entity reference: Carbamoyl-phosphate synthase pyrimidine-specific small chain

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot Q9WZ28 176
organism: Thermotoga maritima

uniprot P49740 85
type: UnificationXref
id: P49740
db: uniprot

uniprot Q9UUY8 111
type: UnificationXref
id: Q9UUY8
db: uniprot

uniprot Q8TNY4 165
type: UnificationXref
id: Q8TNY4
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot A0A2I3SD26 241
organism: Pan troglodytes

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot O94331 6
organism: Schizosaccharomyces pombe

uniprot F7H5B5 255
type: UnificationXref
id: F7H5B5
db: uniprot

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot P41923 17
organism: Yarrowia lipolytica

DS cell adhesion molecule-like 1
type: ProteinReference
xref: uniprot D3ZPL7 55
organism: Rattus norvegicus

ncbitaxon 7227 28
type: UnificationXref
id: 7227
db: ncbitaxon

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot K7BSW8 68
organism: Pan troglodytes

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q381H3 95
organism: Trypanosoma brucei

uniprot G5EC98 256
type: UnificationXref
id: G5EC98
db: uniprot

uniprot P15700 114
type: UnificationXref
id: P15700
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 56

uniprot D3ZPL7 55
type: UnificationXref
id: D3ZPL7
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot Q9WZR0 288
organism: Thermotoga maritima

uniprot F7FKP7 126
type: UnificationXref
id: F7FKP7
db: uniprot

uniprot P07258 137
type: UnificationXref
id: P07258
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1ML89 120
organism: Bos taurus

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot Q58425 157
organism: Methanocaldococcus jannaschii

uniprot Q8TNY3 164
type: UnificationXref
id: Q8TNY3
db: uniprot

uniprot P61136 87
type: UnificationXref
id: P61136
db: uniprot

uniprot F7FS26 127
type: UnificationXref
id: F7FS26
db: uniprot

uniprot Q8LAH8 230
type: UnificationXref
id: Q8LAH8
db: uniprot

uniprot A0A0R4IS05 49
type: UnificationXref
id: A0A0R4IS05
db: uniprot

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot Q9X8R7 47
organism: Streptomyces coelicolor

Dihydroorotate dehydrogenase (quinone)
type: ProteinReference
xref: uniprot P0A7E1 203
organism: Escherichia coli

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot P0A7E3 8
organism: Escherichia coli

uniprot P9WHK9 25
type: UnificationXref
id: P9WHK9
db: uniprot

uniprot Q01637 27
type: UnificationXref
id: Q01637
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot P0A7E5 261
organism: Escherichia coli

Uridylate kinase
type: ProteinReference
xref: P02924
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Uridylate kinase Synonym: Synonym not specified Accession: P02924
comment: ENTITY_REFERENCE_ID_DESC=De novo pyrimidine ribonucleotides biosythesis.PROTEIN.GENERIC.Uridylate kinase
member entity reference: Uridylate kinase

uniprot Q9NRF8 284
type: UnificationXref
id: Q9NRF8
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot F7H5B5 255
organism: Macaca mulatta

uniprot P74494 88
type: UnificationXref
id: P74494
db: uniprot

PARTICIPANT STOICHIOMETRY r4 296
type: Stoichiometry
physical entity: H2O2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 295
type: Stoichiometry
physical entity: orotate
stoichiometric coefficient: 1.0

uniprot G3V816 63
type: UnificationXref
id: G3V816
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q7SXL4 103
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r4 294
type: Stoichiometry
physical entity: O2
stoichiometric coefficient: 1.0

uniprot Q4VA61 97
type: UnificationXref
id: Q4VA61
db: uniprot

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot P74163 181
organism: Synechocystis

ncbitaxon 83333 9
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot B2RQC6 117
type: UnificationXref
id: B2RQC6
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot P9WHK7 269
organism: Mycobacterium tuberculosis

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot P50587 19
organism: Pseudomonas aeruginosa

uniprot F7CDE0 226
type: UnificationXref
id: F7CDE0
db: uniprot

Dihydroorotate dehydrogenase (quinone), mitochondrial
type: ProteinReference
xref: uniprot Q7PYN9 216
organism: Anopheles gambiae

uniprot Q9LD61 194
type: UnificationXref
id: Q9LD61
db: uniprot

uniprot P32748 208
type: UnificationXref
id: P32748
db: uniprot

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot P50589 86
organism: Streptomyces coelicolor

ncbitaxon 224308 15
type: UnificationXref
id: 224308
db: ncbitaxon

CTP synthase
type: ProteinReference
xref: uniprot F7CL99 254
organism: Macaca mulatta

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q7PYN9 216
type: UnificationXref
id: Q7PYN9
db: uniprot

PARTICIPANT STOICHIOMETRY r4 293
type: Stoichiometry
physical entity: dihydroorotate
stoichiometric coefficient: 1.0

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot P25972 14
organism: Bacillus subtilis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__orotate-_PRPP-RIGHT__orotidine_5_phosphate-_PPi-_r5
controller: Orotate phosphoribosyltransferase

CTP synthase
type: ProteinReference
xref: uniprot E2QUQ3 246
organism: Canis lupus familiaris

ncbitaxon 237631 238
type: UnificationXref
id: 237631
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FS26 127
organism: Monodelphis domestica

uniprot P0A7E3 8
type: UnificationXref
id: P0A7E3
db: uniprot

uniprot Q58976 185
type: UnificationXref
id: Q58976
db: uniprot

Carbamoyl-phosphate synthase arginine-specific small chain
type: ProteinReference
xref: uniprot P36838 147
organism: Bacillus subtilis

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot J9P3S5 67
organism: Canis lupus familiaris

uniprot Q58509 33
type: UnificationXref
id: Q58509
db: uniprot

Dihydroorotate dehydrogenase (quinone)
type: ProteinReference
xref: uniprot P9WHL1 210
organism: Mycobacterium tuberculosis

uniprot Q93576 109
type: UnificationXref
id: Q93576
db: uniprot

uniprot P28272 205
type: UnificationXref
id: P28272
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot F6WFF7 252
organism: Monodelphis domestica

uniprot P0A786 179
type: UnificationXref
id: P0A786
db: uniprot

CTP synthase 1
type: ProteinReference
xref: uniprot P17812 263
organism: Homo sapiens

Candida albicans
type: BioSource
xref: ncbitaxon 237561 235

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FKP7 126
organism: Ornithorhynchus anatinus

uniprot A0A2I3SD26 241
type: UnificationXref
id: A0A2I3SD26
db: uniprot

Orotate phosphoribosyltransferase
type: ProteinReference
xref: uniprot P9WHK9 25
organism: Mycobacterium tuberculosis

ncbitaxon 243230 44
type: UnificationXref
id: 243230
db: ncbitaxon

Nucleoside diphosphate kinase
type: ProteinReference
xref: uniprot Q7XC37 104
organism: Oryza sativa

ncbitaxon 100226 48
type: UnificationXref
id: 100226
db: ncbitaxon

uniprot O00746 227
type: UnificationXref
id: O00746
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 30

Aspartate carbamoyltransferase
type: ProteinReference
xref: uniprot Q9RVC0 195
organism: Deinococcus radiodurans

ncbitaxon 243274 46
type: UnificationXref
id: 243274
db: ncbitaxon

Carbamoyl-phosphate synthase large chain
type: ProteinReference
xref: uniprot P9WPK3 151
organism: Mycobacterium tuberculosis

Nucleoside diphosphate kinase B
type: ProteinReference
xref: uniprot P22392 77
organism: Homo sapiens

uniprot P03965 135
type: UnificationXref
id: P03965
db: uniprot

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot P0A6F1 140
organism: Escherichia coli

Carbamoyl-phosphate synthase small chain
type: ProteinReference
xref: uniprot P9WPK5 152
organism: Mycobacterium tuberculosis

Carbamoyl-phosphate synthase pyrimidine-specific small chain
type: ProteinReference
xref: uniprot P25993 143
organism: Bacillus subtilis

Carbamoyl-phosphate synthase pyrimidine-specific large chain
type: ProteinReference
xref: uniprot P25994 144
organism: Bacillus subtilis

uniprot Q5U2N0 275
type: UnificationXref
id: Q5U2N0
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot B7P674 244
organism: Ixodes scapularis

Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
type: ProteinReference
xref: uniprot P25996 204
organism: Bacillus subtilis

CTP synthase
type: ProteinReference
xref: uniprot F7C9L2 253
organism: Ornithorhynchus anatinus

ncbitaxon 9913 52
type: UnificationXref
id: 9913
db: ncbitaxon

Protein URA2
type: ProteinReference
xref: uniprot P07259 138
organism: Saccharomyces cerevisiae

uniprot Q55756 156
type: UnificationXref
id: Q55756
db: uniprot

CTP synthase 1
type: ProteinReference
xref: uniprot P28274 264
organism: Saccharomyces cerevisiae

Dihydroorotate dehydrogenase (fumarate)
type: ProteinReference
xref: uniprot P28272 205
organism: Saccharomyces cerevisiae

Nucleoside diphosphate kinase, mitochondrial
type: ProteinReference
xref: uniprot P34093 81
organism: Dictyostelium discoideum

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Carbamoyl-phosphate synthase arginine-specific small chain
type: ProteinReference
xref: uniprot P07258 137
organism: Saccharomyces cerevisiae

Nucleoside diphosphate kinase 1
type: ProteinReference
xref: uniprot P39207 83
organism: Arabidopsis thaliana

uniprot F7C9L2 253
type: UnificationXref
id: F7C9L2
db: uniprot

Orotidine-5-phosphate decarboxylase
type: Protein
entity reference: Orotidine-5-phosphate decarboxylase
comment: SPECIES_TYPE=PROTEIN

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 107

uniprot F6WFF7 252
type: UnificationXref
id: F6WFF7
db: uniprot

STATE_TRANSITION_LEFT__ATP-_H2O-_UTP-_glutamine-RIGHT__glutamate-_CTP-_PO4-_ADP-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 318
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 321
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 319
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 316
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 320
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 323
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 317
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 322
left: UTP
left: H2O
left: ATP
left: glutamine
interaction type: STATE_TRANSITION
right: PO4
right: CTP
right: ADP
right: glutamate

Nucleoside diphosphate kinase, cytosolic
type: ProteinReference
xref: uniprot P22887 78
organism: Dictyostelium discoideum

uniprot Q9KXR2 193
type: UnificationXref
id: Q9KXR2
db: uniprot

uniprot Q9RX68 43
type: UnificationXref
id: Q9RX68
db: uniprot

CTP synthase
type: ProteinReference
xref: uniprot Q4GZ95 272
organism: Trypanosoma brucei

2 ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE