DARPP-32
type: Protein
entity reference: DARPP-32
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein 4.1
type: ProteinReference
xref: uniprot P11171 380
xref: PTHR23280:SF12
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re3 592
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

G protein subunit alpha i3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot H2PZK9 282
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re3 593
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

PTHR24248:SF87
type: RelationshipXref
id: PTHR24248:SF87
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 383
xref: PTHR13809:SF21
organism: Bos taurus

Sodium-dependent dopamine transporter
type: ProteinReference
xref: uniprot Q01959 327
xref: PTHR11616:SF38
organism: Homo sapiens

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q08462 97
xref: PTHR45627:SF6
organism: Homo sapiens

uniprot P36975 219
type: UnificationXref
id: P36975
db: uniprot

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: PTHR43563:SF11
xref: uniprot Q64133 341
organism: Mus musculus

Mus musculus
type: BioSource
xref: ncbitaxon 10090 12

uniprot P62136 437
type: UnificationXref
id: P62136
db: uniprot

DOPA
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s260 sa159 512
cellular location: exocytic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PTHR19305:SF14
type: RelationshipXref
id: PTHR19305:SF14
db: PANTHER Family
relationship type: By Homology

D1/D5
type: Protein
entity reference: D1/D5
feature: COMPLEX PARTICIPANT BINDING FEATURE s187 sa200 488
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Erythrocyte membrane protein band 4.1 like 1
type: ProteinReference
xref: uniprot A0A2I3RMK9 134
xref: PTHR23280:SF24
organism: Pan troglodytes

uniprot P62880 167
type: UnificationXref
id: P62880
db: uniprot

uniprot Q3T0Y8 238
type: UnificationXref
id: Q3T0Y8
db: uniprot

D3/D4-GRB2 complex
type: Complex
component stoichiometry: D2 D3 D4 s171 sa198 STOICHIOMETRY ID COMPLEX
component stoichiometry: GRB2 s170 sa197 STOICHIOMETRY ID COMPLEX
component: GRB2
component: D2/D3/D4
feature: COMPLEX BINDING FEATURE s169 csa28 555
feature: COMPLEX BINDING FEATURE s169 csa28 553
cellular location: axon terminus

Erythrocyte membrane protein band 4.1 like 3
type: ProteinReference
xref: uniprot H2QE82 379
xref: PTHR23280:SF20
organism: Pan troglodytes

uniprot P20711 318
type: UnificationXref
id: P20711
db: uniprot

DOPA s260 sa159 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

Dopamine receptor D5
type: ProteinReference
xref: PTHR24248:SF170
xref: uniprot H2RAB4 109
organism: Pan troglodytes

STATE_TRANSITION_LEFT__Protein_Phosphatase_1-RIGHT__Protein_Phosphatase_1-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 628
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 629
left: Protein Phosphatase-1
interaction type: STATE_TRANSITION
right: Protein Phosphatase-1

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
type: ProteinReference
xref: PTHR11668:SF377
xref: uniprot P62136 437
organism: Homo sapiens

uniprot P31323 63
type: UnificationXref
id: P31323
db: uniprot

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
type: ProteinReference
xref: PTHR11668:SF377
xref: uniprot P62138 439
organism: Rattus norvegicus

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
type: ProteinReference
xref: uniprot P62137 438
xref: PTHR11668:SF377
organism: Mus musculus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A0A0R4IZT6 416
xref: PTHR11668:SF204
organism: Danio rerio

Guanine nucleotide-binding protein G(z) subunit alpha
type: ProteinReference
xref: uniprot O70443 349
xref: PTHR10218:SF65
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot F7CTP1 148
organism: Macaca mulatta

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60879 222
xref: PTHR19305:SF5
organism: Mus musculus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60878 221
xref: PTHR19305:SF5
organism: Gallus gallus

HETERODIMER_ASSOCIATION_LEFT__VAT2-_DOPA-RIGHT__Complex__VAT2_DOPA_-_re67
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 649
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 648
participant stoichiometry: PARTICIPANT STOICHIOMETRY re67 647
left: VAT2
left: DOPA
interaction type: HETERODIMER_ASSOCIATION
right: Complex (VAT2/DOPA)

uniprot Q9H4G0 136
type: UnificationXref
id: Q9H4G0
db: uniprot

eco ECO:0000245 157
type: UnificationXref
id: ECO:0000245
db: eco

Putative synaptobrevin homologue SNC1/2 (Eurofung)
type: ProteinReference
xref: uniprot Q5ASG1 239
organism: Emericella nidulans

Gbeta/gamma
type: Complex
component stoichiometry: Ggamma s216 sa234 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s215 sa233 STOICHIOMETRY ID COMPLEX
component: Ggamma
component: Gbeta
feature: COMPLEX BINDING FEATURE s217 csa36 541
feature: COMPLEX BINDING FEATURE s217 csa36 539
cellular location: cytosol

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P60877 220
xref: PTHR19305:SF5
organism: Macaca mulatta

uniprot P25115 114
type: UnificationXref
id: P25115
db: uniprot

PKA
type: ProteinReference
xref: P05946
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.PKA
comment: ENTITY_REFERENCE_NOTES=Long Name: protein kinase A Synonym: protein kinase A Accession: P05946
member entity reference: Uncharacterized protein
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: Protein kinase A catalytic subunit isoform 1
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: AGAP001384-PA
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: PRKACB isoform 3
member entity reference: Protein kinase A catalytic subunit
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: AGAP008039-PA (Fragment)
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta a
member entity reference: AGAP004940-PA
member entity reference: PRKAR2A isoform 1
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit PRKX
member entity reference: Protein kinase, X-linked
member entity reference: cAMP-dependent protein kinase catalytic subunit 3
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: PRKACG isoform 1
member entity reference: Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: Protein kinase A catalytic subunit isoform 2

TRANSPORT_LEFT__ACh-RIGHT__ACh-_re6
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 577
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 578
left: ACh
interaction type: TRANSPORT
right: ACh

Synaptosomal-associated protein 25
type: ProteinReference
xref: PTHR19305:SF5
xref: uniprot P60880 223
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re87 568
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ D1/D5)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re87 567
type: Stoichiometry
physical entity: Complex (Gsalpha/Gbeta/ Ggamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re87 566
type: Stoichiometry
physical entity: D1/D5
stoichiometric coefficient: 1.0

uniprot F7E427 150
type: UnificationXref
id: F7E427
db: uniprot

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q2KJD2 237
organism: Bos taurus

uniprot O88533 315
type: UnificationXref
id: O88533
db: uniprot

D2 D3 D4 s40 sa49 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

AC
type: Protein
entity reference: AC
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot F1N611 135
type: UnificationXref
id: F1N611
db: uniprot

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s254 sa257 480
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

D2/D3 EPB41L1 complex
type: Complex
component stoichiometry: D2 D3 D4 s156 sa189 STOICHIOMETRY ID COMPLEX
component stoichiometry: EPB41L1 s155 sa192 STOICHIOMETRY ID COMPLEX
component: EPB41L1
component: D2/D3/D4
feature: COMPLEX BINDING FEATURE s154 csa25 521
feature: COMPLEX BINDING FEATURE s154 csa25 523
cellular location: axon terminus

PTHR10157:SF29
type: RelationshipXref
id: PTHR10157:SF29
db: PANTHER Family
relationship type: By Homology

cAMP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gialpha
type: ProteinReference
xref: P05958
standard name: Gi-protein, alpha subunit
comment: ENTITY_REFERENCE_NOTES=Long Name: Gi alpha subunit Synonym: Synonym not specified Accession: P05958
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.G_sub_i_endsub__alpha_
member entity reference: G protein subunit alpha i3
member entity reference: GNAI2 protein
member entity reference: Guanine nucleotide-binding protein G(K) subunit alpha
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
member entity reference: Guanine nucleotide-binding protein G(k) subunit alpha
member entity reference: Uncharacterized protein
member entity reference: G protein subunit alpha i2
member entity reference: Gnai3 protein
member entity reference: G protein subunit alpha i1

Synaptobrevin-1
type: ProteinReference
xref: uniprot O02495 209
xref: PTHR45701:SF3
organism: Caenorhabditis elegans

uniprot P04177 452
type: UnificationXref
id: P04177
db: uniprot

uniprot P18459 455
type: UnificationXref
id: P18459
db: uniprot

axon terminus
type: CellularLocationVocabulary
xref: GO GO:0043679 4

Dopamine receptor 1
type: ProteinReference
xref: uniprot P41596 115
xref: PTHR24247:SF238
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re69 641
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re69 642
type: Stoichiometry
physical entity: VAT2
stoichiometric coefficient: 1.0

PTHR24247:SF205
type: RelationshipXref
id: PTHR24247:SF205
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re69 643
type: Stoichiometry
physical entity: Complex (VAT2/DOPA)
stoichiometric coefficient: 1.0

Potassium channel subfamily K member 9
type: ProteinReference
xref: uniprot Q9ES08 271
xref: PTHR11003:SF75
organism: Rattus norvegicus

uniprot O54912 268
type: UnificationXref
id: O54912
db: uniprot

Synaptic vesicular amine transporter
type: ProteinReference
xref: uniprot Q05940 308
xref: PTHR23506:SF30
organism: Homo sapiens

Ggamma s254 sa257 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

SLC18A2 isoform 1
type: ProteinReference
xref: uniprot H2Q2M8 306
xref: PTHR23506:SF30
organism: Pan troglodytes

D2/D3/D4
type: Protein
entity reference: D2/D3/D4
feature: COMPLEX PARTICIPANT BINDING FEATURE s137 sa178 474
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q7Q3T7 79
type: UnificationXref
id: Q7Q3T7
db: uniprot

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot F7FNW0 313
organism: Macaca mulatta

EPB41L2
type: ProteinReference
xref: P05952
standard name: erythrocyte membrane protein band 4.1-like 2
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.EPB41L2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: erythrocyte membrane protein band 4.1-like 2 Synonym: 4.1G,nonerythroid protein 4.1, general type Accession: P05952
member entity reference: Band 4.1-like protein 2
member entity reference: EPB41L2 isoform 1
member entity reference: Uncharacterized protein

uniprot P24529 456
type: UnificationXref
id: P24529
db: uniprot

Amine oxidase [flavin-containing] B
type: ProteinReference
xref: uniprot P27338 339
xref: PTHR43563:SF5
organism: Homo sapiens

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot O70404 212
xref: PTHR45701:SF7
organism: Mus musculus

D1 D5 s208 sa29 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D1/D5
stoichiometric coefficient: 1.0

PTHR24247:SF217
type: RelationshipXref
id: PTHR24247:SF217
db: PANTHER Family
relationship type: By Homology

uniprot P21398 338
type: UnificationXref
id: P21398
db: uniprot

Vesicle associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot F6Z5I2 198
organism: Monodelphis domestica

Filamin-A
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot P21333 302
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__GNAZ-_D1_D5-RIGHT__D5_GNAZ_complex-_re79
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re79 605
participant stoichiometry: PARTICIPANT STOICHIOMETRY re79 604
participant stoichiometry: PARTICIPANT STOICHIOMETRY re79 606
left: GNAZ
left: D1/D5
interaction type: HETERODIMER_ASSOCIATION
right: D5-GNAZ complex

Chloride intracellular channel protein
type: ProteinReference
xref: uniprot F6Q8V4 412
xref: PTHR45476:SF1
organism: Macaca mulatta

uniprot O44419 211
type: UnificationXref
id: O44419
db: uniprot

uniprot P50146 290
type: UnificationXref
id: P50146
db: uniprot

uniprot A5PEW5 185
type: UnificationXref
id: A5PEW5
db: uniprot

PTHR24056:SF46
type: RelationshipXref
id: PTHR24056:SF46
db: PANTHER Family
relationship type: By Homology

MODULATION
type: RelationshipTypeVocabulary

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

00696
type: UnificationXref
id: MOD:00696
db: mod

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: uniprot Q6DBV8 74
xref: PTHR24353:SF135
organism: Danio rerio

PTHR11003:SF138
type: RelationshipXref
id: PTHR11003:SF138
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7165 77
type: UnificationXref
id: 7165
db: ncbitaxon

Amine oxidase
type: ProteinReference
xref: uniprot A0A140T837 329
xref: PTHR43563:SF5
organism: Bos taurus

Gsalpha
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s212 sa228 518
feature: Gsalpha s212 sa228 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

D(2) dopamine receptor
type: ProteinReference
xref: uniprot P20288 365
xref: PTHR24248:SF87
organism: Bos taurus

uniprot F6RIM7 277
type: UnificationXref
id: F6RIM7
db: uniprot

D2 D3 D4 s36 sa59 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

G protein subunit alpha i2
type: ProteinReference
xref: uniprot H2QMN4 283
xref: PTHR10218:SF73
organism: Pan troglodytes

EPB41L2
type: Protein
entity reference: EPB41L2
feature: COMPLEX PARTICIPANT BINDING FEATURE s184 sa205 494
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gsalpha s214 sa227 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PTHR19850:SF27
type: RelationshipXref
id: PTHR19850:SF27
db: PANTHER Family
relationship type: By Homology

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot O95721 213
xref: PTHR19305:SF9
organism: Homo sapiens

uniprot F7H4T0 361
type: UnificationXref
id: F7H4T0
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot F6TFY2 389
type: UnificationXref
id: F6TFY2
db: uniprot

PTHR19850:SF29
type: RelationshipXref
id: PTHR19850:SF29
db: PANTHER Family
relationship type: By Homology

PTHR19850:SF28
type: RelationshipXref
id: PTHR19850:SF28
db: PANTHER Family
relationship type: By Homology

PTHR38537:SF5
type: RelationshipXref
id: PTHR38537:SF5
db: PANTHER Family
relationship type: By Homology

uniprot P90986 457
type: UnificationXref
id: P90986
db: uniprot

uniprot Q8BRU6 309
type: UnificationXref
id: Q8BRU6
db: uniprot

DAT
type: ProteinReference
xref: P05962
standard name: Sodium-dependent dopamine transporter
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.DAT
comment: ENTITY_REFERENCE_NOTES=Long Name: Sodium-dependent dopamine transporter Synonym: DA transporter,DAT Accession: P05962
member entity reference: Sodium-dependent dopamine transporter
member entity reference: Transporter

uniprot Q7T3D3 295
type: UnificationXref
id: Q7T3D3
db: uniprot

uniprot Q2KJD2 237
type: UnificationXref
id: Q2KJD2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50150 399
organism: Homo sapiens

Protein Phosphatase-1
type: ProteinReference
xref: P05969
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.Protein Phosphatase-1
comment: ENTITY_REFERENCE_NOTES=Long Name: Protein Phosphatase-1 Synonym: Synonym not specified Accession: P05969
member entity reference: Serine/threonine-protein phosphatase
member entity reference: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
member entity reference: Serine/threonine-protein phosphatase alpha-1 isoform
member entity reference: Serine/threonine-protein phosphatase PP1-beta
member entity reference: Serine/threonine-protein phosphatase PP1-beta catalytic subunit
member entity reference: Serine/threonine-protein phosphatase (Fragment)
member entity reference: Serine/threonine-protein phosphatase alpha-3 isoform
member entity reference: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
member entity reference: Serine/threonine-protein phosphatase alpha-2 isoform

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot A0A3Q1LYB4 184
organism: Bos taurus

Amine oxidase [flavin-containing] B
type: ProteinReference
xref: uniprot Q8BW75 343
xref: PTHR43563:SF5
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 400
xref: PTHR13809:SF21
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__DARPP_32-RIGHT__DARPP_32-_re9
controller: PKA

Dopamine receptor D5
type: ProteinReference
xref: PTHR24248:SF136
xref: uniprot F6VS22 106
organism: Xenopus tropicalis

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P50146 290
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot A0A1D5QDW1 180
organism: Macaca mulatta

ncbitaxon 8364 33
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot E1BW98 142
type: UnificationXref
id: E1BW98
db: uniprot

Chloride intracellular channel protein 6
type: ProteinReference
xref: uniprot Q96NY7 415
xref: PTHR45476:SF1
organism: Homo sapiens

uniprot P18489 214
type: UnificationXref
id: P18489
db: uniprot

uniprot E2R907 189
type: UnificationXref
id: E2R907
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_protein__D1_D5_-_Dopamine-RIGHT__Complex__GDP_G_protein__D1_D5__Dopamine_-_re4
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 591
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 590
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 589
left: Complex (GDP/G-protein/ D1/D5)
left: Dopamine
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-protein/ D1/D5/ Dopamine)

Midbrain DA neuron substantia niagra c5
type: CellularLocationVocabulary
comment: Midbrain DA neuron (substantia niagra)

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P27791 62
xref: PTHR24353:SF82
organism: Rattus norvegicus

uniprot F7G4Q0 35
type: UnificationXref
id: F7G4Q0
db: uniprot

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q5RKN6 121
organism: Danio rerio

uniprot P63088 441
type: UnificationXref
id: P63088
db: uniprot

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9BV40 252
xref: PTHR45701:SF7
organism: Homo sapiens

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot K7ADQ0 93
organism: Pan troglodytes

Dopamine receptor 2 protein transcript variant 1
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot A9YZQ5 354
organism: Gallus gallus

TH isoform 6
type: ProteinReference
xref: PTHR11473:SF18
xref: uniprot H2Q2W7 451
organism: Pan troglodytes

Soluble NSF attachment protein 29
type: ProteinReference
xref: uniprot P83351 230
xref: PTHR19305:SF9
organism: Caenorhabditis elegans

PTHR19850:SF31
type: RelationshipXref
id: PTHR19850:SF31
db: PANTHER Family
relationship type: By Homology

Band 4.1-like protein 2
type: ProteinReference
xref: PTHR23280:SF17
xref: uniprot O43491 132
organism: Homo sapiens

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s213 sa226 516
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR13809:SF1
type: RelationshipXref
id: PTHR13809:SF1
db: PANTHER Family
relationship type: By Homology

Catechol O-methyltransferase isoform MB-COMT
type: ProteinReference
xref: uniprot F6QFW9 5
xref: PTHR43836:SF3
organism: Macaca mulatta

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: uniprot P21396 336
xref: PTHR43563:SF11
organism: Rattus norvegicus

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: PTHR43563:SF11
xref: uniprot P21397 337
organism: Homo sapiens

DARPP-32
type: Protein
entity reference: DARPP-32
feature: ACTIVE 17
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: uniprot P21398 338
xref: PTHR43563:SF11
organism: Bos taurus

uniprot Q5IS72 373
type: UnificationXref
id: Q5IS72
db: uniprot

uniprot F6UBJ8 192
type: UnificationXref
id: F6UBJ8
db: uniprot

uniprot Q7PPI8 76
type: UnificationXref
id: Q7PPI8
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q503 29
organism: Macaca mulatta

Dopamine receptor D4
type: ProteinReference
xref: PTHR24248:SF143
xref: uniprot H2Q2V4 362
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot P63216 408
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 407
xref: PTHR13809:SF11
organism: Homo sapiens

D(1A) dopamine receptor
type: ProteinReference
xref: PTHR24247:SF217
xref: uniprot P18901 111
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot P63214 406
organism: Bos taurus

EPB41
type: ProteinReference
xref: P05966
standard name: erythrocyte membrane protein band 4.1
comment: ENTITY_REFERENCE_NOTES=Long Name: erythrocyte membrane protein band 4.1 Synonym: Synonym not specified Accession: P05966
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.EPB41
member entity reference: Protein 4.1
member entity reference: Band 4.1-like protein 1
member entity reference: Erythrocyte membrane protein band 4.1 like 1
member entity reference: Band 4.1-like protein 2
member entity reference: 4.1B
member entity reference: Uncharacterized protein
member entity reference: Erythrocyte membrane protein band 4.1 like 3
member entity reference: EPB41 isoform 1
member entity reference: Band 4.1-like protein 3
member entity reference: EPB41L2 isoform 1

DRD1 isoform 1
type: ProteinReference
xref: PTHR24248:SF139
xref: uniprot H2QS18 108
organism: Pan troglodytes

DOPA
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7A472 280
type: UnificationXref
id: F7A472
db: uniprot

Gialpha
type: Protein
entity reference: Gialpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s250 sa250 528
feature: Gialpha s250 sa250 rs1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

GNAZ
type: ProteinReference
xref: P05964
standard name: guanine nucleotide-binding protein, alpha z polypeptide
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: guanine nucleotide-binding protein, alpha z polypeptide Synonym: Gz alpha Accession: P05964
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.GNAZ
member entity reference: Guanine nucleotide-binding protein G(z) subunit alpha
member entity reference: Guanine nucleotide-binding protein G(Z) subunit alpha
member entity reference: G protein subunit alpha z
member entity reference: Uncharacterized protein

PTHR43563:SF5
type: RelationshipXref
id: PTHR43563:SF5
db: PANTHER Family
relationship type: By Homology

uniprot P21918 113
type: UnificationXref
id: P21918
db: uniprot

GRB2
type: Protein
entity reference: GRB2
feature: COMPLEX PARTICIPANT BINDING FEATURE s170 sa197 554
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot E2RJB3 386
type: UnificationXref
id: E2RJB3
db: uniprot

uniprot F6VE51 263
type: UnificationXref
id: F6VE51
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot F7CYH8 359
organism: Macaca mulatta

uniprot E2RRA1 22
type: UnificationXref
id: E2RRA1
db: uniprot

Protein phosphatase 1 regulatory inhibitor subunit 1B
type: ProteinReference
xref: PTHR15417:SF2
xref: uniprot A0A2I3S2W6 123
organism: Pan troglodytes

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
type: ProteinReference
xref: uniprot Q8WMS6 449
xref: PTHR11668:SF377
organism: Canis lupus familiaris

P
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=ION

Gbeta s210 sa229 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

D2/D3/D4
type: Protein
entity reference: D2/D3/D4
feature: COMPLEX PARTICIPANT BINDING FEATURE s148 sa185 460
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P04897 284
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P04899 285
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re78 612
type: Stoichiometry
physical entity: D5_minusEPB41L2 complex
stoichiometric coefficient: 1.0

Dopamine beta-hydroxylase
type: ProteinReference
xref: PTHR10157:SF29
xref: uniprot P09172 175
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re78 610
type: Stoichiometry
physical entity: EPB41L2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re78 611
type: Stoichiometry
physical entity: D1/D5
stoichiometric coefficient: 1.0

Potassium channel subfamily K member
type: ProteinReference
xref: PTHR11003:SF138
xref: uniprot Q5TZ59 270
organism: Danio rerio

Synaptobrevin
type: ProteinReference
xref: PTHR45701:SF10
xref: uniprot P18489 214
organism: Drosophila melanogaster

uniprot Q6NVU2 445
type: UnificationXref
id: Q6NVU2
db: uniprot

uniprot Q05B25 353
type: UnificationXref
id: Q05B25
db: uniprot

SNAP25 homologous protein SNAP29
type: ProteinReference
xref: uniprot Q9SD96 258
organism: Arabidopsis thaliana

TRANSPORT
type: RelationshipTypeVocabulary

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_re18
control type: ACTIVATION
controller: PKA

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot W4YRI6 84
xref: PTHR11635:SF162
organism: Strongylocentrotus purpuratus

uniprot P63078 405
type: UnificationXref
id: P63078
db: uniprot

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 157

uniprot P63026 226
type: UnificationXref
id: P63026
db: uniprot

uniprot A1Z6N4 311
type: UnificationXref
id: A1Z6N4
db: uniprot

Gialpha s250 sa250 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F6UFJ7 193
type: UnificationXref
id: F6UFJ7
db: uniprot

Synaptosomal-associated protein 25-A
type: ProteinReference
xref: uniprot Q5TZ66 242
xref: PTHR19305:SF5
organism: Danio rerio

GNAZ
type: Protein
entity reference: GNAZ
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot H2QYH6 334
type: UnificationXref
id: H2QYH6
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A5PEW5 185
organism: Caenorhabditis elegans

uniprot P12367 50
type: UnificationXref
id: P12367
db: uniprot

uniprot Q9WTP0 137
type: UnificationXref
id: Q9WTP0
db: uniprot

GNAI2 protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot A7MBH9 274
organism: Bos taurus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

uniprot F7D6Q6 300
type: UnificationXref
id: F7D6Q6
db: uniprot

Synaptobrevin homolog 2
type: ProteinReference
xref: uniprot P33328 218
organism: Saccharomyces cerevisiae

uniprot F6Q503 29
type: UnificationXref
id: F6Q503
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P00515 46
organism: Bos taurus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P00517 47
xref: PTHR24353:SF82
organism: Bos taurus

Serine/threonine-protein phosphatase alpha-1 isoform
type: ProteinReference
xref: uniprot P48461 434
xref: PTHR11668:SF300
organism: Drosophila melanogaster

uniprot A0A1D5QIS2 181
type: UnificationXref
id: A0A1D5QIS2
db: uniprot

Syntaxin-3
type: ProteinReference
xref: uniprot Q13277 233
xref: PTHR19957:SF34
organism: Homo sapiens

uniprot E2RRD1 24
type: UnificationXref
id: E2RRD1
db: uniprot

Protein Phosphatase-1
type: Protein
entity reference: Protein Phosphatase-1
feature: ACTIVE 17
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 36

uniprot A9V782 421
type: UnificationXref
id: A9V782
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 142
xref: PTHR19850:SF28
organism: Gallus gallus

uniprot C0JPT7 297
type: UnificationXref
id: C0JPT7
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6VUT7 195
xref: PTHR19305:SF5
organism: Ornithorhynchus anatinus

PTHR43836:SF3
type: RelationshipXref
id: PTHR43836:SF3
db: PANTHER Family
relationship type: By Homology

K PLUS channel s39 sa47 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.92
comment: MODIFICATION_RESIDUE_NAME=

PTHR11616:SF38
type: RelationshipXref
id: PTHR11616:SF38
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RI77 43
xref: PTHR24353:SF128
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re60 673
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re60 672
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

DAT s101 sa160 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DAT
stoichiometric coefficient: 1.0

Gbeta
type: Protein
entity reference: D1/D5
feature: COMPLEX PARTICIPANT BINDING FEATURE s27 sa223 470
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot F7G3J2 152
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P08752 286
xref: PTHR10218:SF73
organism: Mus musculus

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot P08754 288
organism: Homo sapiens

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot P08753 287
organism: Rattus norvegicus

AGAP004940-PA
type: ProteinReference
xref: uniprot Q7PPI8 76
xref: PTHR11635:SF162
organism: Anopheles gambiae

Probable tyrosine decarboxylase 2
type: ProteinReference
xref: uniprot Q9M0G4 324
organism: Arabidopsis thaliana

EPB41L2
type: Protein
entity reference: EPB41L2
feature: COMPLEX PARTICIPANT BINDING FEATURE s159 sa191 498
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 6669 28
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot Q6J4I0 127
type: UnificationXref
id: Q6J4I0
db: uniprot

uniprot P21728 112
type: UnificationXref
id: P21728
db: uniprot

uniprot A0A1D5QT69 304
type: UnificationXref
id: A0A1D5QT69
db: uniprot

PARTICIPANT STOICHIOMETRY re12 620
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9ERB0 253
xref: PTHR19305:SF9
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re12 621
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re2
controller: cAMP

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot Q9HAV0 172
organism: Homo sapiens

uniprot O02495 209
type: UnificationXref
id: O02495
db: uniprot

K PLUS channel s38 sa43 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.92
comment: MODIFICATION_RESIDUE_NAME=

STATE_TRANSITION_LEFT__Gialpha-RIGHT__P-_Gialpha-_re92
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re92 669
participant stoichiometry: PARTICIPANT STOICHIOMETRY re92 670
participant stoichiometry: PARTICIPANT STOICHIOMETRY re92 671
left: Gialpha
interaction type: STATE_TRANSITION
right: Gialpha
right: P

GO GO:0070382 2
type: UnificationXref
id: GO:0070382
db: GO

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: uniprot P38400 289
xref: PTHR10218:SF73
organism: Canis lupus familiaris

uniprot P36873 433
type: UnificationXref
id: P36873
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 255

uniprot F7CYH8 359
type: UnificationXref
id: F7CYH8
db: uniprot

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P61952 401
type: UnificationXref
id: P61952
db: uniprot

Complex (GDP/G-protein/ D2/D3/ D4/Dopamine)
type: Complex
component stoichiometry: GDP s10 sa55 STOICHIOMETRY ID COMPLEX
component stoichiometry: Dopamine s31 sa56 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s249 sa252 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gialpha s251 sa249 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s247 sa253 STOICHIOMETRY ID COMPLEX
component: Gialpha
component: D2/D3/D4
component: Ggamma
component: Dopamine
component: Gbeta
feature: COMPLEX BINDING FEATURE s30 csa7 507
feature: COMPLEX BINDING FEATURE s30 csa7 501
feature: COMPLEX BINDING FEATURE s30 csa7 503
feature: COMPLEX BINDING FEATURE s30 csa7 505
feature: COMPLEX BINDING FEATURE s30 csa7 499
cellular location: axon terminus

PTHR45701:SF6
type: RelationshipXref
id: PTHR45701:SF6
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF7
type: RelationshipXref
id: PTHR45701:SF7
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF5
type: RelationshipXref
id: PTHR45701:SF5
db: PANTHER Family
relationship type: By Homology

PTHR45701:SF3
type: RelationshipXref
id: PTHR45701:SF3
db: PANTHER Family
relationship type: By Homology

uniprot P19020 364
type: UnificationXref
id: P19020
db: uniprot

PTHR45701:SF1
type: RelationshipXref
id: PTHR45701:SF1
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 410
xref: PTHR13809:SF19
organism: Homo sapiens

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7FMV0 429
xref: PTHR11668:SF204
organism: Ornithorhynchus anatinus

Na+
type: SmallMolecule
cellular location: Midbrain DA neuron substantia niagra c5
comment: SPECIES_TYPE=ION

Gialpha s242 sa245 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gialpha
stoichiometric coefficient: 1.0

ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

Danio rerio
type: BioSource
xref: ncbitaxon 7955 19

Tyrosine 3-monooxygenase
type: ProteinReference
xref: PTHR11473:SF15
xref: uniprot P18459 455
organism: Drosophila melanogaster

Syntaxin-3
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot Q08849 231
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__Gbeta_gamma-_Gsalpha-RIGHT__Complex__Gsalpha_Gbeta__Ggamma_-_re86
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re86 573
participant stoichiometry: PARTICIPANT STOICHIOMETRY re86 572
participant stoichiometry: PARTICIPANT STOICHIOMETRY re86 571
left: Gbeta/gamma
left: Gsalpha
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Gsalpha/Gbeta/ Ggamma)

D(1A) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF139
xref: uniprot P21728 112
organism: Homo sapiens

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q17QQ3 235
xref: PTHR19305:SF5
organism: Bos taurus

uniprot P60880 223
type: UnificationXref
id: P60880
db: uniprot

uniprot A0A3Q1NGS8 140
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

uniprot Q8BLD9 119
type: UnificationXref
id: Q8BLD9
db: uniprot

uniprot E2QUL2 188
type: UnificationXref
id: E2QUL2
db: uniprot

uniprot Q9W1I8 260
type: UnificationXref
id: Q9W1I8
db: uniprot

Synaptic vesicular amine transporter
type: ProteinReference
xref: uniprot Q8BRU6 309
xref: PTHR23506:SF30
organism: Mus musculus

uniprot H2RI77 43
type: UnificationXref
id: H2RI77
db: uniprot

Protein Phosphatase-1
type: Protein
entity reference: Protein Phosphatase-1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Transporter
type: ProteinReference
xref: PTHR11616:SF38
xref: uniprot F7CT33 325
organism: Macaca mulatta

uniprot H2Q2V4 362
type: UnificationXref
id: H2Q2V4
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__D1_D5-_Complex__Gsalpha_Gbeta__Ggamma_-RIGHT__Complex__GDP_G_protein__D1_D5_-_re87
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re87 566
participant stoichiometry: PARTICIPANT STOICHIOMETRY re87 567
participant stoichiometry: PARTICIPANT STOICHIOMETRY re87 568
left: Complex (Gsalpha/Gbeta/ Ggamma)
left: D1/D5
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-protein/ D1/D5)

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot O44419 211
xref: PTHR19305:SF14
organism: Strongylocentrotus purpuratus

Chloride intracellular channel protein
type: ProteinReference
xref: uniprot A0A2I3S2C9 411
xref: PTHR45476:SF1
organism: Pan troglodytes

uniprot O70404 212
type: UnificationXref
id: O70404
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Dopamine-RIGHT__norepinephrine-_re70
controller: DBH

uniprot Q3ZCA7 293
type: UnificationXref
id: Q3ZCA7
db: uniprot

eco ECO:0000305 186
type: UnificationXref
id: ECO:0000305
db: eco

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q62442 243
xref: PTHR45701:SF1
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re51 588
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 16

PARTICIPANT STOICHIOMETRY re51 587
type: Stoichiometry
physical entity: tyrosine
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(Z) subunit alpha
type: ProteinReference
xref: uniprot F7GJC8 347
xref: PTHR10218:SF65
organism: Macaca mulatta

uniprot A0A2I3S2C9 411
type: UnificationXref
id: A0A2I3S2C9
db: uniprot

D1/D5
type: Protein
entity reference: D1/D5
feature: COMPLEX PARTICIPANT BINDING FEATURE s28 sa23 544
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P18901 111
type: UnificationXref
id: P18901
db: uniprot

uniprot E2R2S8 143
type: UnificationXref
id: E2R2S8
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

K+
type: SmallMolecule
comment: SPECIES_TYPE=ION

INHIBITION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY re90 680
type: Stoichiometry
physical entity: Complex (Gialpha/Gbeta/ Ggamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re90 681
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re90 682
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ D2/D3/ D4)
stoichiometric coefficient: 1.0

DBH
type: Protein
entity reference: DBH
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Growth factor receptor-bound protein 2
type: ProteinReference
xref: PTHR46037:SF4
xref: uniprot Q66II3 122
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY re71 637
type: Stoichiometry
physical entity: CLIC6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re71 638
type: Stoichiometry
physical entity: D2/D3/D4 CLIC6 complex
stoichiometric coefficient: 1.0

uniprot P21333 302
type: UnificationXref
id: P21333
db: uniprot

PARTICIPANT STOICHIOMETRY re71 636
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re19
control type: ACTIVATION
controller: K+ channel

PARTICIPANT STOICHIOMETRY re18 600
type: Stoichiometry
physical entity: K+ channel
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re18 601
type: Stoichiometry
physical entity: K+ channel
stoichiometric coefficient: 1.0

G protein subunit alpha z
type: ProteinReference
xref: uniprot E2R3J3 344
xref: PTHR10218:SF65
organism: Canis lupus familiaris

ncbitaxon 10116 16
type: UnificationXref
id: 10116
db: ncbitaxon

Gialpha
type: Protein
entity reference: Gialpha
feature: ACTIVE 17
feature: Gialpha s252 sa255 rs1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot H2QUY0 397
type: UnificationXref
id: H2QUY0
db: uniprot

ncbitaxon 7668 85
type: UnificationXref
id: 7668
db: ncbitaxon

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q0V7N0 232
xref: PTHR45701:SF1
organism: Bos taurus

HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_protein__D2_D3__D4_-_Dopamine-RIGHT__Complex__GDP_G_protein__D2_D3__D4_Dopamine_-_re15
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 609
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 608
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 607
left: Dopamine
left: Complex (GDP/G-protein/ D2/D3/ D4)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-protein/ D2/D3/ D4/Dopamine)

Ggamma s213 sa226 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

uniprot P60026 370
type: UnificationXref
id: P60026
db: uniprot

DOPA
type: SmallMolecule
cellular location: exocytic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot H2Q6V7 431
xref: PTHR11668:SF377
organism: Pan troglodytes

TH
type: Protein
entity reference: TH
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR23280:SF17
xref: uniprot F7BWK5 130
organism: Macaca mulatta

uniprot F6Q9S4 30
type: UnificationXref
id: F6Q9S4
db: uniprot

uniprot P48193 381
type: UnificationXref
id: P48193
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QIS2 181
xref: PTHR45701:SF7
organism: Macaca mulatta

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s216 sa234 542
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dopamine receptor D2-like
type: ProteinReference
xref: PTHR24248:SF118
xref: uniprot X1WBR1 376
organism: Danio rerio

HETERODIMER_ASSOCIATION_LEFT__Complex__Gialpha_Gbeta__Ggamma_-_D2_D3_D4-RIGHT__Complex__GDP_G_protein__D2_D3__D4_-_re90
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re90 682
participant stoichiometry: PARTICIPANT STOICHIOMETRY re90 681
participant stoichiometry: PARTICIPANT STOICHIOMETRY re90 680
left: Complex (Gialpha/Gbeta/ Ggamma)
left: D2/D3/D4
interaction type: HETERODIMER_ASSOCIATION
right: Complex (GDP/G-protein/ D2/D3/ D4)

PKA
type: Protein
entity reference: PKA
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot F7E3I6 360
type: UnificationXref
id: F7E3I6
db: uniprot

uniprot P54313 161
type: UnificationXref
id: P54313
db: uniprot

ACTIVE 17
type: EntityFeature
comment: Active state

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P34099 65
xref: PTHR24353:SF37
organism: Dictyostelium discoideum

HETERODIMER_ASSOCIATION_LEFT__D2_D3_D4-_CLIC6-RIGHT__D2_D3_D4_CLIC6_complex-_re71
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re71 636
participant stoichiometry: PARTICIPANT STOICHIOMETRY re71 637
participant stoichiometry: PARTICIPANT STOICHIOMETRY re71 638
left: CLIC6
left: D2/D3/D4
interaction type: HETERODIMER_ASSOCIATION
right: D2/D3/D4 CLIC6 complex

cAMP-dependent protein kinase catalytic subunit 3
type: ProteinReference
xref: uniprot P16912 56
xref: PTHR24353:SF37
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re84 583
type: Stoichiometry
physical entity: Gbeta/gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re84 584
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__SNARE_Complex-RIGHT__SNARE_Complex-_re5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 586
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 585
left: SNARE Complex
interaction type: STATE_TRANSITION
right: SNARE Complex

uniprot Q60829 126
type: UnificationXref
id: Q60829
db: uniprot

PARTICIPANT STOICHIOMETRY re84 581
type: Stoichiometry
physical entity: Gsalpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re84 582
type: Stoichiometry
physical entity: Complex (D1/D5/ Dopamine)
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re1
controller: AC

PARTICIPANT STOICHIOMETRY re84 580
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ D1/D5/ Dopamine)
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P16520 156
organism: Homo sapiens

D2/D3/D4
type: Protein
entity reference: D2/D3/D4
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re9 564
type: Stoichiometry
physical entity: DARPP-32
stoichiometric coefficient: 1.0

uniprot H2QMN4 283
type: UnificationXref
id: H2QMN4
db: uniprot

PARTICIPANT STOICHIOMETRY re9 565
type: Stoichiometry
physical entity: DARPP-32
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re84 579
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q3ZB92 72
organism: Danio rerio

Protein kinase A catalytic subunit isoform 1
type: ProteinReference
xref: uniprot Q9GNR4 83
xref: PTHR24353:SF67
organism: Leishmania major

uniprot Q6PHV0 247
type: UnificationXref
id: Q6PHV0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NZY0 345
xref: PTHR10218:SF65
organism: Gallus gallus

uniprot Q5TZ66 242
type: UnificationXref
id: Q5TZ66
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s249 sa252 506
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q61327 328
type: UnificationXref
id: Q61327
db: uniprot

DISSOCIATION_LEFT__Complex__DAT_dopamine_-RIGHT__DAT-_dopamine-_Na_PLUS_-_re64
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 656
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 655
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 654
participant stoichiometry: PARTICIPANT STOICHIOMETRY re64 657
left: Complex (DAT/dopamine)
interaction type: DISSOCIATION
right: Na+
right: DAT
right: dopamine

norepinephrine
type: SmallMolecule
cellular location: Midbrain DA neuron substantia niagra c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7HGF9 173
type: UnificationXref
id: F7HGF9
db: uniprot

uniprot Q5RKN6 121
type: UnificationXref
id: Q5RKN6
db: uniprot

uniprot Q9DC51 296
type: UnificationXref
id: Q9DC51
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot F7FXA9 151
organism: Macaca mulatta

D(2) dopamine receptor
type: ProteinReference
xref: uniprot P14416 363
xref: PTHR24248:SF87
organism: Homo sapiens

Dopamine D2c receptor
type: ProteinReference
xref: uniprot Q7T1A1 374
xref: PTHR24248:SF87
organism: Danio rerio

uniprot P30729 368
type: UnificationXref
id: P30729
db: uniprot

Gsalpha s212 sa228 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Potassium channel subfamily K member 3
type: ProteinReference
xref: PTHR11003:SF138
xref: uniprot O14649 266
organism: Homo sapiens

uniprot Q3T0E7 444
type: UnificationXref
id: Q3T0E7
db: uniprot

Dopamine beta-hydroxylase
type: ProteinReference
xref: PTHR10157:SF29
xref: uniprot Q64237 178
organism: Mus musculus

uniprot O00161 208
type: UnificationXref
id: O00161
db: uniprot

DOPA decarb.
type: ProteinReference
xref: P05961
standard name: Aromatic L-amino acid decarboxylase
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.DOPA decarb.
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Aromatic L-amino acid decarboxylase Synonym: DOPA decarboxylase Accession: P05961
member entity reference: Ddc protein
member entity reference: MIP05841p
member entity reference: Biogenic Amine Synthesis related
member entity reference: Probable tyrosine decarboxylase 2
member entity reference: Aromatic-L-amino-acid decarboxylase
member entity reference: Probable aromatic-L-amino-acid decarboxylase
member entity reference: Os10g0380800 protein
member entity reference: Dopa decarboxylase
member entity reference: AGAP009091-PA
member entity reference: Protein CBR-BAS-1

Dopamine receptor D2
type: ProteinReference
xref: uniprot F7E3I6 360
xref: PTHR24248:SF87
organism: Xenopus tropicalis

Synaptic vesicular amine transporter
type: ProteinReference
xref: uniprot Q01827 307
xref: PTHR23506:SF30
organism: Rattus norvegicus

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
type: ProteinReference
xref: uniprot P61287 436
xref: PTHR46259:SF1
organism: Bos taurus

Potassium channel subfamily K member 3
type: ProteinReference
xref: PTHR11003:SF138
xref: uniprot O54912 268
organism: Rattus norvegicus

Tyrosine 3-monooxygenase
type: ProteinReference
xref: PTHR11473:SF15
xref: uniprot P90986 457
organism: Caenorhabditis elegans

uniprot A0A1L1RMC6 417
type: UnificationXref
id: A0A1L1RMC6
db: uniprot

D1 D5 s25 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D1/D5
stoichiometric coefficient: 1.0

ncbitaxon 284812 251
type: UnificationXref
id: 284812
db: ncbitaxon

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

D1/D5
type: Protein
entity reference: D1/D5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

DOPA decarb.
type: Protein
entity reference: DOPA decarb.
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3TP36 310
type: UnificationXref
id: A0A2I3TP36
db: uniprot

Filamin A
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot C0JPT7 297
organism: Rattus norvegicus

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot Q9Z2P6 262
xref: PTHR19305:SF9
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TUG0 346
xref: PTHR10218:SF65
organism: Monodelphis domestica

uniprot F7FMV0 429
type: UnificationXref
id: F7FMV0
db: uniprot

uniprot F6Y3N2 146
type: UnificationXref
id: F6Y3N2
db: uniprot

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

CDK5
type: Protein
entity reference: CDK5
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q922R0 82
organism: Mus musculus

uniprot P52287 159
type: UnificationXref
id: P52287
db: uniprot

Dopamine
type: SmallMolecule
cellular location: exocytic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

MODULATION
type: Control
xref: MODULATION
controlled: Fine motor control
controller: ACh

uniprot A0A1D5QYR9 182
type: UnificationXref
id: A0A1D5QYR9
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__GRB2-_D2_D3_D4-RIGHT__D3_D4_GRB2_complex-_re77
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re77 619
participant stoichiometry: PARTICIPANT STOICHIOMETRY re77 617
participant stoichiometry: PARTICIPANT STOICHIOMETRY re77 618
left: D2/D3/D4
left: GRB2
interaction type: HETERODIMER_ASSOCIATION
right: D3/D4-GRB2 complex

Tyrosine 3-monooxygenase
type: ProteinReference
xref: PTHR11473:SF18
xref: uniprot P24529 456
organism: Mus musculus

Gsalpha s204 sa222 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gsalpha
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(z) subunit alpha
type: ProteinReference
xref: uniprot P19627 352
xref: PTHR10218:SF65
organism: Rattus norvegicus

uniprot P61954 403
type: UnificationXref
id: P61954
db: uniprot

cAMP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P31109 216
type: UnificationXref
id: P31109
db: uniprot

uniprot Q8BHB9 414
type: UnificationXref
id: Q8BHB9
db: uniprot

uniprot G7NKD7 378
type: UnificationXref
id: G7NKD7
db: uniprot

PARTICIPANT STOICHIOMETRY re13 615
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re13 616
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

uniprot P29387 158
type: UnificationXref
id: P29387
db: uniprot

TH
type: ProteinReference
xref: P05970
standard name: Tyrosine Hydroxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Tyrosine Hydroxylase Synonym: TH Accession: P05970
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.TH
member entity reference: Tyrosine 3-monooxygenase
member entity reference: Tyrosine hydroxylase 2
member entity reference: TH isoform 6
member entity reference: Uncharacterized protein

eco ECO:0000353 133
type: UnificationXref
id: ECO:0000353
db: eco

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 155
xref: PTHR19850:SF27
organism: Bos taurus

Probable aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: uniprot P34751 319
organism: Caenorhabditis elegans

uniprot Q01959 327
type: UnificationXref
id: Q01959
db: uniprot

MIP05841p
type: ProteinReference
xref: uniprot A1Z6N4 311
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot F7D6Q6 300
organism: Ornithorhynchus anatinus

uniprot F7BWK5 130
type: UnificationXref
id: F7BWK5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T2 37
xref: PTHR24353:SF37
organism: Macaca mulatta

uniprot H2RER5 42
type: UnificationXref
id: H2RER5
db: uniprot

PTHR11668:SF204
type: RelationshipXref
id: PTHR11668:SF204
db: PANTHER Family
relationship type: By Homology

uniprot Q63666 244
type: UnificationXref
id: Q63666
db: uniprot

uniprot A8X844 312
type: UnificationXref
id: A8X844
db: uniprot

uniprot P14416 363
type: UnificationXref
id: P14416
db: uniprot

PTHR46259:SF1
type: RelationshipXref
id: PTHR46259:SF1
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot H2QUY0 397
organism: Pan troglodytes

FLNA
type: ProteinReference
xref: P05959
standard name: filamin A
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.FLNA
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: filamin A Synonym: actin-binding protein 280,filamin alpha Accession: P05959
member entity reference: Uncharacterized protein
member entity reference: Filamin-A isoform 2
member entity reference: Filamin A
member entity reference: Filamin-A

Protein kinase, X-linked
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q5BK52 73
organism: Rattus norvegicus

Serine/threonine-protein phosphatase PP1-beta catalytic subunit
type: ProteinReference
xref: PTHR11668:SF472
xref: uniprot Q3SWW9 443
organism: Bos taurus

uniprot Q3ZB92 72
type: UnificationXref
id: Q3ZB92
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s243 sa246 484
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

VAT2
type: ProteinReference
xref: P05960
standard name: Synaptic vesicular amine transporter
comment: ENTITY_REFERENCE_NOTES=Long Name: Synaptic vesicular amine transporter Synonym: Monoamine transporter,Solute carrier family 18 member 2,VAT2,Vesicular amine transporter 2 Accession: P05960
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.VAT2
member entity reference: Solute carrier family 18 (Vesicular monoamine), member 2
member entity reference: SLC18A2 isoform 1
member entity reference: Synaptic vesicular amine transporter
member entity reference: Uncharacterized protein

uniprot F7FNW0 313
type: UnificationXref
id: F7FNW0
db: uniprot

uniprot O77680 110
type: UnificationXref
id: O77680
db: uniprot

PARTICIPANT STOICHIOMETRY re70 640
type: Stoichiometry
physical entity: norepinephrine
stoichiometric coefficient: 1.0

PTHR13809:SF19
type: RelationshipXref
id: PTHR13809:SF19
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re70 639
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

uniprot Q28HP6 236
type: UnificationXref
id: Q28HP6
db: uniprot

D2/D3/D4
type: Protein
entity reference: D2/D3/D4
feature: COMPLEX PARTICIPANT BINDING FEATURE s40 sa49 534
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot Q92356 250
organism: Schizosaccharomyces pombe

uniprot Q08849 231
type: UnificationXref
id: Q08849
db: uniprot

PTHR13809:SF11
type: RelationshipXref
id: PTHR13809:SF11
db: PANTHER Family
relationship type: By Homology

uniprot P08754 288
type: UnificationXref
id: P08754
db: uniprot

uniprot A5PKD6 141
type: UnificationXref
id: A5PKD6
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 91

TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re19
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 599
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 598
left: K+
interaction type: TRANSPORT
right: K+

uniprot P17289 454
type: UnificationXref
id: P17289
db: uniprot

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s207 sa224 472
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1MYW8 387
type: UnificationXref
id: F1MYW8
db: uniprot

uniprot P34099 65
type: UnificationXref
id: P34099
db: uniprot

PTHR13809:SF21
type: RelationshipXref
id: PTHR13809:SF21
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 614
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 613
left: AC
interaction type: STATE_TRANSITION
right: AC

Ggamma s248 sa254 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Filamin A
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot F1PWW0 299
organism: Canis lupus familiaris

uniprot F1PWW0 299
type: UnificationXref
id: F1PWW0
db: uniprot

uniprot Q01827 307
type: UnificationXref
id: Q01827
db: uniprot

uniprot P11017 155
type: UnificationXref
id: P11017
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot F1N169 298
organism: Bos taurus

uniprot Q9Z2H5 138
type: UnificationXref
id: Q9Z2H5
db: uniprot

uniprot P51829 96
type: UnificationXref
id: P51829
db: uniprot

Chloride intracellular channel protein 6
type: ProteinReference
xref: uniprot Q8BHB9 414
organism: Mus musculus

uniprot P61287 436
type: UnificationXref
id: P61287
db: uniprot

uniprot F7GFT6 430
type: UnificationXref
id: F7GFT6
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 23

Amine oxidase [flavin-containing] B
type: ProteinReference
xref: PTHR43563:SF5
xref: uniprot P19643 335
organism: Rattus norvegicus

ncbitaxon 7227 54
type: UnificationXref
id: 7227
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 140
xref: PTHR19850:SF31
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 153
xref: PTHR19850:SF28
organism: Pan troglodytes

uniprot P14173 317
type: UnificationXref
id: P14173
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q80TL1 99
xref: PTHR45627:SF6
organism: Mus musculus

VAMP3 isoform 1
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot G2HIJ9 201
organism: Pan troglodytes

D3/EPB41L2 complex
type: Complex
component stoichiometry: D2 D3 D4 s158 sa190 STOICHIOMETRY ID COMPLEX
component stoichiometry: EPB41L2 s159 sa191 STOICHIOMETRY ID COMPLEX
component: EPB41L2
component: D2/D3/D4
feature: COMPLEX BINDING FEATURE s157 csa26 497
feature: COMPLEX BINDING FEATURE s157 csa26 495
cellular location: axon terminus

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot E2R907 189
xref: PTHR19305:SF5
organism: Canis lupus familiaris

uniprot F7DL70 92
type: UnificationXref
id: F7DL70
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR11668:SF300
xref: uniprot B3S6H7 423
organism: Trichoplax adhaerens

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51828 95
organism: Homo sapiens

PTHR23280:SF24
type: RelationshipXref
id: PTHR23280:SF24
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 393
xref: PTHR13809:SF11
organism: Monodelphis domestica

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51829 96
organism: Mus musculus

PTHR23280:SF20
type: RelationshipXref
id: PTHR23280:SF20
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re91 679
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

SNAP25 homologous protein SNAP33
type: ProteinReference
xref: uniprot Q9S7P9 257
organism: Arabidopsis thaliana

Dopamine receptor D3
type: ProteinReference
xref: uniprot E2R3W6 355
xref: PTHR24248:SF154
organism: Canis lupus familiaris

Protein phosphatase 1 regulatory subunit 1B
type: ProteinReference
xref: PTHR15417:SF2
xref: uniprot P07516 125
organism: Bos taurus

uniprot Q7T1A1 374
type: UnificationXref
id: Q7T1A1
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A0A1L1RMC6 417
xref: PTHR11668:SF204
organism: Gallus gallus

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: uniprot P51817 67
xref: PTHR24353:SF133
organism: Homo sapiens

K+ channel
type: Protein
entity reference: K+ channel
feature: K PLUS channel s38 sa43 rs1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

D(1C) dopamine receptor
type: ProteinReference
xref: uniprot F6WET9 107
organism: Xenopus tropicalis

uniprot P00517 47
type: UnificationXref
id: P00517
db: uniprot

uniprot F7GJC8 347
type: UnificationXref
id: F7GJC8
db: uniprot

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot Q29450 98
xref: PTHR45627:SF9
organism: Bos taurus

ncbitaxon 559292 217
type: UnificationXref
id: 559292
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 146
xref: PTHR19850:SF27
organism: Monodelphis domestica

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot P81900 70
xref: PTHR11635:SF162
organism: Drosophila melanogaster

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot P22612 60
xref: PTHR24353:SF137
organism: Homo sapiens

uniprot K7ADQ0 93
type: UnificationXref
id: K7ADQ0
db: uniprot

ncbitaxon 7955 19
type: UnificationXref
id: 7955
db: ncbitaxon

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

uniprot H2RCB8 206
type: UnificationXref
id: H2RCB8
db: uniprot

Gbeta s243 sa246 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re91 675
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re91 676
type: Stoichiometry
physical entity: Complex (Gbeta/Ggamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re91 677
type: Stoichiometry
physical entity: Gialpha
stoichiometric coefficient: 1.0

SNARE Complex
type: Protein
entity reference: SNARE Complex
feature: SNARE Complex s62 sa2 rs1
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Gsalpha s204 sa222 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re91 678
type: Stoichiometry
physical entity: Complex (D2/D3/ D4/Dopamine)
stoichiometric coefficient: 1.0

uniprot Q95136 120
type: UnificationXref
id: Q95136
db: uniprot

uniprot Q27687 71
type: UnificationXref
id: Q27687
db: uniprot

PARTICIPANT STOICHIOMETRY re91 674
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ D2/D3/ D4/Dopamine)
stoichiometric coefficient: 1.0

D2/D3/D4
type: Protein
entity reference: D2/D3/D4
feature: COMPLEX PARTICIPANT BINDING FEATURE s171 sa198 556
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q6NW93 75
type: UnificationXref
id: Q6NW93
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot F6Q9S4 30
xref: PTHR11635:SF156
organism: Bos taurus

uniprot A4IFL6 383
type: UnificationXref
id: A4IFL6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot F7CXD0 149
organism: Monodelphis domestica

uniprot A0A140T837 329
type: UnificationXref
id: A0A140T837
db: uniprot

uniprot F1LQT1 87
type: UnificationXref
id: F1LQT1
db: uniprot

D2/D3/D4
type: Protein
entity reference: D2/D3/D4
feature: COMPLEX PARTICIPANT BINDING FEATURE s166 sa193 558
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: uniprot H2QFK0 39
xref: PTHR24353:SF82
organism: Pan troglodytes

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot F6VM87 194
xref: PTHR19305:SF5
organism: Monodelphis domestica

uniprot F7GI54 393
type: UnificationXref
id: F7GI54
db: uniprot

Potassium two pore domain channel subfamily K member 9
type: ProteinReference
xref: uniprot G3N1D1 265
xref: PTHR11003:SF75
organism: Bos taurus

uniprot Q7ZVR3 447
type: UnificationXref
id: Q7ZVR3
db: uniprot

Potassium channel subfamily K member
type: ProteinReference
xref: uniprot F6VE51 263
xref: PTHR11003:SF75
organism: Macaca mulatta

uniprot P62874 165
type: UnificationXref
id: P62874
db: uniprot

uniprot F6QFW9 5
type: UnificationXref
id: F6QFW9
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 77

uniprot Q5BK52 73
type: UnificationXref
id: Q5BK52
db: uniprot

uniprot Q6DBV8 74
type: UnificationXref
id: Q6DBV8
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 387
xref: PTHR13809:SF19
organism: Bos taurus

uniprot P60879 222
type: UnificationXref
id: P60879
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 17
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot P26769 94
xref: PTHR45627:SF6
organism: Rattus norvegicus

uniprot P23763 215
type: UnificationXref
id: P23763
db: uniprot

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O09044 210
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re17 603
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re17 602
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Dopamine receptor D3
type: ProteinReference
xref: uniprot F1QG18 357
xref: PTHR24248:SF154
organism: Danio rerio

Serine/threonine-protein phosphatase PP1-beta
type: ProteinReference
xref: uniprot P48727 435
xref: PTHR11668:SF462
organism: Caenorhabditis elegans

dopamine
type: SmallMolecule
cellular location: Midbrain DA neuron substantia niagra c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot P05031 316
organism: Drosophila melanogaster

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF14
xref: uniprot A8X8S6 187
organism: Caenorhabditis briggsae

Erythrocyte membrane protein band 4.1 like 1
type: ProteinReference
xref: PTHR23280:SF24
xref: uniprot F1N611 135
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re68 645
type: Stoichiometry
physical entity: VAT2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re68 644
type: Stoichiometry
physical entity: Complex (VAT2/DOPA)
stoichiometric coefficient: 1.0

SNARE Complex s62 sa2 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

EPB41L1
type: ProteinReference
xref: P05953
standard name: erythrocyte membrane protein band 4.1-like 1
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.EPB41L1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: erythrocyte membrane protein band 4.1-like 1 Synonym: 4.1N,nonerythroid protein 4.1, neuron type Accession: P05953
member entity reference: Band 4.1-like protein 1
member entity reference: Erythrocyte membrane protein band 4.1 like 1

PARTICIPANT STOICHIOMETRY re68 646
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

uniprot F6U709 358
type: UnificationXref
id: F6U709
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__EPB41-_D2_D3_D4-RIGHT__D2_D3_D4_EBP41_complex-_re73
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re73 635
participant stoichiometry: PARTICIPANT STOICHIOMETRY re73 633
participant stoichiometry: PARTICIPANT STOICHIOMETRY re73 634
left: D2/D3/D4
left: EPB41
interaction type: HETERODIMER_ASSOCIATION
right: D2/D3/D4 EBP41 complex

DOPamine receptor
type: ProteinReference
xref: PTHR24247:SF238
xref: uniprot Q86ME6 118
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY re92 670
type: Stoichiometry
physical entity: P
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re92 671
type: Stoichiometry
physical entity: Gialpha
stoichiometric coefficient: 1.0

uniprot F7A943 199
type: UnificationXref
id: F7A943
db: uniprot

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 133

Vesicle-associated membrane protein 2
type: ProteinReference
xref: uniprot Q7SZZ5 248
organism: Danio rerio

uniprot A0A1D5RHE7 86
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

PTHR23280:SF17
type: RelationshipXref
id: PTHR23280:SF17
db: PANTHER Family
relationship type: By Homology

PTHR23280:SF12
type: RelationshipXref
id: PTHR23280:SF12
db: PANTHER Family
relationship type: By Homology

uniprot Q05940 308
type: UnificationXref
id: Q05940
db: uniprot

ncbitaxon 9544 6
type: UnificationXref
id: 9544
db: ncbitaxon

uniprot Q05547 442
type: UnificationXref
id: Q05547
db: uniprot

PARTICIPANT STOICHIOMETRY re92 669
type: Stoichiometry
physical entity: Gialpha
stoichiometric coefficient: 1.0

Complex (D1/D5/ Dopamine)
type: Complex
component stoichiometry: Dopamine s255 sa26 STOICHIOMETRY ID COMPLEX
component stoichiometry: D1 D5 s25 sa25 STOICHIOMETRY ID COMPLEX
component: Dopamine
component: D1/D5
feature: COMPLEX BINDING FEATURE s8 csa2 537
feature: COMPLEX BINDING FEATURE s8 csa2 535
cellular location: cytosol

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: uniprot Q3ZCA7 293
xref: PTHR10218:SF230
organism: Bos taurus

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s244 sa247 486
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q8MJ44 81
type: UnificationXref
id: Q8MJ44
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot F1PMQ9 356
type: UnificationXref
id: F1PMQ9
db: uniprot

uniprot Q8MJ46 448
type: UnificationXref
id: Q8MJ46
db: uniprot

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
type: ProteinReference
xref: PTHR11668:SF377
xref: uniprot Q3T0E7 444
organism: Bos taurus

PTHR19305:SF5
type: RelationshipXref
id: PTHR19305:SF5
db: PANTHER Family
relationship type: By Homology

Tyramine beta-hydroxylase
type: ProteinReference
xref: uniprot Q86B61 179
xref: PTHR10157:SF29
organism: Drosophila melanogaster

PTHR19305:SF9
type: RelationshipXref
id: PTHR19305:SF9
db: PANTHER Family
relationship type: By Homology

Dopamine s255 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

AC
type: Protein
entity reference: AC
feature: ACTIVE 17
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

D5-GNAZ complex
type: Complex
component stoichiometry: GNAZ s186 sa204 STOICHIOMETRY ID COMPLEX
component stoichiometry: D1 D5 s187 sa200 STOICHIOMETRY ID COMPLEX
component: D1/D5
component: GNAZ
feature: COMPLEX BINDING FEATURE s185 csa30 487
feature: COMPLEX BINDING FEATURE s185 csa30 489
cellular location: cytosol

uniprot Q29450 98
type: UnificationXref
id: Q29450
db: uniprot

ncbitaxon 227321 240
type: UnificationXref
id: 227321
db: ncbitaxon

PTHR19305:SF4
type: RelationshipXref
id: PTHR19305:SF4
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

uniprot E9GNI4 27
type: UnificationXref
id: E9GNI4
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__D2_D3_D4-_EPB41L2-RIGHT__D3_EPB41L2_complex-_re75
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re75 627
participant stoichiometry: PARTICIPANT STOICHIOMETRY re75 626
participant stoichiometry: PARTICIPANT STOICHIOMETRY re75 625
left: EPB41L2
left: D2/D3/D4
interaction type: HETERODIMER_ASSOCIATION
right: D3/EPB41L2 complex

GNB4 protein
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot A5PKD6 141
organism: Bos taurus

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 14

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F7FD32 281
organism: Macaca mulatta

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

uniprot Q3SWW9 443
type: UnificationXref
id: Q3SWW9
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: uniprot H9EQQ4 44
xref: PTHR24353:SF82
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__DOPA-RIGHT__Dopamine-_re66
controller: DOPA decarb.

TRANSPORT_LEFT__Dopamine-RIGHT__Dopamine-_re8
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 570
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 569
left: Dopamine
interaction type: TRANSPORT
right: Dopamine

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P22694 61
organism: Homo sapiens

uniprot Q9Z2P6 262
type: UnificationXref
id: Q9Z2P6
db: uniprot

uniprot P34751 319
type: UnificationXref
id: P34751
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Dopamine-RIGHT__Dopamine-_re8
control type: ACTIVATION
controller: SNARE Complex

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 593
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 592
left: AC
interaction type: STATE_TRANSITION
right: AC

uniprot Q6NSN2 342
type: UnificationXref
id: Q6NSN2
db: uniprot

IDA
type: EvidenceCodeVocabulary

PRKAR2A isoform 1
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot K7AEL3 45
organism: Pan troglodytes

D1 D5 s183 sa201 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D1/D5
stoichiometric coefficient: 1.0

uniprot P63025 225
type: UnificationXref
id: P63025
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 391
xref: PTHR13809:SF19
organism: Macaca mulatta

Sodium-dependent dopamine transporter
type: ProteinReference
xref: uniprot Q61327 328
xref: PTHR11616:SF38
organism: Mus musculus

Synaptobrevin homolog 1
type: ProteinReference
xref: uniprot P31109 216
organism: Saccharomyces cerevisiae

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Dopamine-RIGHT__Dopamine-_re17
control type: ACTIVATION
controller: SNARE Complex

uniprot Q3LS21 269
type: UnificationXref
id: Q3LS21
db: uniprot

PTHR10218:SF73
type: RelationshipXref
id: PTHR10218:SF73
db: PANTHER Family
relationship type: By Homology

TRANSPORT_LEFT__Dopamine-RIGHT__Dopamine-_re17
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 603
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 602
left: Dopamine
interaction type: TRANSPORT
right: Dopamine

VAT2
type: Protein
entity reference: VAT2
feature: COMPLEX PARTICIPANT BINDING FEATURE s261 sa158 510
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re61 665
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
type: ProteinReference
xref: PTHR11668:SF204
xref: uniprot P36873 433
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re61 666
type: Stoichiometry
physical entity: Mg2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re61 667
type: Stoichiometry
physical entity: sa3_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re61 668
type: Stoichiometry
physical entity: Mg2+
stoichiometric coefficient: 1.0

uniprot E2R3W6 355
type: UnificationXref
id: E2R3W6
db: uniprot

tyrosine
type: SmallMolecule
cellular location: Midbrain DA neuron substantia niagra c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

G protein subunit alpha i3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q5I080 294
organism: Xenopus tropicalis

PTHR10218:SF65
type: RelationshipXref
id: PTHR10218:SF65
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot P21396 336
type: UnificationXref
id: P21396
db: uniprot

Gsalpha s197 sa231 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

D(4) dopamine receptor
type: ProteinReference
xref: uniprot P30729 368
xref: PTHR24247:SF205
organism: Rattus norvegicus

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 186

D(3) dopamine receptor
type: ProteinReference
xref: uniprot P30728 367
xref: PTHR24248:SF154
organism: Mus musculus

depolarization
type: Pathway

uniprot A0A2I3SR99 183
type: UnificationXref
id: A0A2I3SR99
db: uniprot

uniprot P68181 68
type: UnificationXref
id: P68181
db: uniprot

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 17
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR43563:SF11
type: RelationshipXref
id: PTHR43563:SF11
db: PANTHER Family
relationship type: By Homology

Complex (Gsalpha/Gbeta/ Ggamma)
type: Complex
component stoichiometry: D1 D5 s27 sa223 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gsalpha s204 sa222 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s207 sa224 STOICHIOMETRY ID COMPLEX
component: Gsalpha
component: Gbeta
component: Ggamma
feature: COMPLEX BINDING FEATURE s203 csa35 469
feature: COMPLEX BINDING FEATURE s203 csa35 467
feature: COMPLEX BINDING FEATURE s203 csa35 471
cellular location: cytosol

PARTICIPANT STOICHIOMETRY re6 578
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 577
type: Stoichiometry
physical entity: ACh
stoichiometric coefficient: 1.0

PTHR24247:SF238
type: RelationshipXref
id: PTHR24247:SF238
db: PANTHER Family
relationship type: By Homology

uniprot X1WBR1 376
type: UnificationXref
id: X1WBR1
db: uniprot

Gialpha
type: Protein
entity reference: Gialpha
feature: Gialpha s242 sa245 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s242 sa245 482
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot H2QLC1 348
type: UnificationXref
id: H2QLC1
db: uniprot

uniprot H2RAB4 109
type: UnificationXref
id: H2RAB4
db: uniprot

PARTICIPANT STOICHIOMETRY re64 655
type: Stoichiometry
physical entity: DAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re64 656
type: Stoichiometry
physical entity: dopamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re64 657
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

uniprot H2R3A6 154
type: UnificationXref
id: H2R3A6
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 147
xref: PTHR19850:SF28
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re64 654
type: Stoichiometry
physical entity: Complex (DAT/dopamine)
stoichiometric coefficient: 1.0

t-SNARE protein aex-4
type: ProteinReference
xref: uniprot G5EEN8 202
organism: Caenorhabditis elegans

uniprot Q9S7P9 257
type: UnificationXref
id: Q9S7P9
db: uniprot

uniprot P63027 227
type: UnificationXref
id: P63027
db: uniprot

Protein kinase A catalytic subunit isoform 2
type: ProteinReference
xref: uniprot E9AFM1 25
xref: PTHR24353:SF67
organism: Leishmania major

GNAZ s186 sa204 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GNAZ
stoichiometric coefficient: 1.0

uniprot Q64237 178
type: UnificationXref
id: Q64237
db: uniprot

Biogenic Amine Synthesis related
type: ProteinReference
xref: uniprot O45137 314
xref: PTHR11999:SF70
organism: Caenorhabditis elegans

HETERODIMER_ASSOCIATION_LEFT__FLNA-_D2_D3_D4-RIGHT__D2_D3_FLNA_complex-_re76
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re76 624
participant stoichiometry: PARTICIPANT STOICHIOMETRY re76 622
participant stoichiometry: PARTICIPANT STOICHIOMETRY re76 623
left: D2/D3/D4
left: FLNA
interaction type: HETERODIMER_ASSOCIATION
right: D2/D3-FLNA complex

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot P23763 215
xref: PTHR45701:SF1
organism: Homo sapiens

Band 4.1-like protein 1
type: ProteinReference
xref: PTHR23280:SF24
xref: uniprot Q9Z2H5 138
organism: Mus musculus

G protein subunit beta 3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot H2R3A6 154
organism: Pan troglodytes

uniprot Q61011 169
type: UnificationXref
id: Q61011
db: uniprot

uniprot Q80TL1 99
type: UnificationXref
id: Q80TL1
db: uniprot

uniprot F6PVT7 145
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot P21964 13
type: UnificationXref
id: P21964
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F6ZAV4 90
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7A472 280
organism: Xenopus tropicalis

Gialpha s251 sa249 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gialpha
stoichiometric coefficient: 1.0

uniprot A0A2I3RMK9 134
type: UnificationXref
id: A0A2I3RMK9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G4Q0 35
xref: PTHR24353:SF82
organism: Monodelphis domestica

uniprot Q8AWE0 375
type: UnificationXref
id: Q8AWE0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23506:SF30
xref: uniprot A0A1D5QT69 304
organism: Macaca mulatta

4.1B
type: ProteinReference
xref: uniprot G7NKD7 378
xref: PTHR23280:SF20
organism: Macaca mulatta

Protein phosphatase 1 regulatory subunit 1B isoform 1
type: ProteinReference
xref: PTHR15417:SF2
xref: uniprot F7CTZ0 124
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6U709 358
xref: PTHR24248:SF154
organism: Macaca mulatta

uniprot H2R1G3 41
type: UnificationXref
id: H2R1G3
db: uniprot

dopamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s102 sa161 466
cellular location: Midbrain DA neuron substantia niagra c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ggamma s216 sa234 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Tyrosine 3-monooxygenase
type: ProteinReference
xref: PTHR11473:SF18
xref: uniprot P07101 453
organism: Homo sapiens

Dopamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s31 sa56 502
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Leishmania major
type: BioSource
xref: ncbitaxon 5664 26

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 3

Dopamine receptor D1
type: ProteinReference
xref: uniprot B6E506 100
xref: PTHR24248:SF139
organism: Danio rerio

PTHR45476:SF1
type: RelationshipXref
id: PTHR45476:SF1
db: PANTHER Family
relationship type: By Homology

D(2) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot F1PMQ9 356
organism: Canis lupus familiaris

uniprot Q7SZZ5 248
type: UnificationXref
id: Q7SZZ5
db: uniprot

PNAT
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__VAT2-_DOPA-RIGHT__Complex__VAT2_DOPA_-_re67
pathway component: HETERODIMER_ASSOCIATION_LEFT__D2_D3_D4-_CLIC6-RIGHT__D2_D3_D4_CLIC6_complex-_re71
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re3
pathway component: TRANSPORT_LEFT__ACh-RIGHT__ACh-_re6
pathway component: STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_re18
pathway component: STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_re65
pathway component: STATE_TRANSITION_LEFT__Gsalpha-RIGHT__P-_Gsalpha-_re85
pathway component: STATE_TRANSITION_LEFT__DARPP_32-RIGHT__DARPP_32-_re9
pathway component: DISSOCIATION_LEFT__Complex__DAT_dopamine_-RIGHT__DAT-_dopamine-_Na_PLUS_-_re64
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re12
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_protein__D2_D3__D4_-_Dopamine-RIGHT__Complex__GDP_G_protein__D2_D3__D4_Dopamine_-_re15
pathway component: HETERODIMER_ASSOCIATION_LEFT__EPB41L1-_D2_D3_D4-RIGHT__D2_D3_EPB41L1_complex-_re74
pathway component: HETERODIMER_ASSOCIATION_LEFT__EPB41L2-_D1_D5-RIGHT__D5_minusEPB41L2_complex-_re78
pathway component: HETERODIMER_ASSOCIATION_LEFT__D1_D5-_Complex__Gsalpha_Gbeta__Ggamma_-RIGHT__Complex__GDP_G_protein__D1_D5_-_re87
pathway component: HETERODIMER_ASSOCIATION_LEFT__DAT-_Dopamine-_Na_PLUS_-RIGHT__Complex__DAT_dopamine_-_re63
pathway component: TRANSPORT_LEFT__K_PLUS_-RIGHT__K_PLUS_-_re19
pathway component: TRANSPORT_LEFT__Dopamine-RIGHT__Dopamine-_re8
pathway component: HETERODIMER_ASSOCIATION_LEFT__FLNA-_D2_D3_D4-RIGHT__D2_D3_FLNA_complex-_re76
pathway component: TRIGGER
pathway component: DISSOCIATION_LEFT__Complex__VAT2_DOPA_-RIGHT__VAT2-_DOPA-_re57
pathway component: DISSOCIATION_LEFT__Complex__VAT2_DOPA_-RIGHT__VAT2-_DOPA-_re68
pathway component: STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_re51
pathway component: STATE_TRANSITION_LEFT__SNARE_Complex-RIGHT__SNARE_Complex-_re5
pathway component: STATE_TRANSITION_LEFT__Dopamine-_Mg2_PLUS_-RIGHT__sa3_degraded-_Mg2_PLUS_-_re61
pathway component: STATE_TRANSITION_LEFT__Protein_Phosphatase_1-RIGHT__Protein_Phosphatase_1-_re10
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__GDP_G_protein__D1_D5_-_Dopamine-RIGHT__Complex__GDP_G_protein__D1_D5__Dopamine_-_re4
pathway component: DISSOCIATION_LEFT__GTP-_Complex__GDP_G_protein__D1_D5__Dopamine_-RIGHT__Gsalpha-_Complex__D1_D5__Dopamine_-_Gbeta_gamma-_GDP-_re84
pathway component: DISSOCIATION_LEFT__Complex__GDP_G_protein__D2_D3__D4_Dopamine_-_GTP-RIGHT__Complex__Gbeta_Ggamma_-_Gialpha-_Complex__D2_D3__D4_Dopamine_-_GDP-_re91
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re2
pathway component: HETERODIMER_ASSOCIATION_LEFT__GRB2-_D2_D3_D4-RIGHT__D3_D4_GRB2_complex-_re77
pathway component: HETERODIMER_ASSOCIATION_LEFT__DOPA-_VAT2-RIGHT__Complex__VAT2_DOPA_-_re69
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re14
pathway component: TRANSPORT_LEFT__Dopamine-RIGHT__Dopamine-_re17
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Gialpha_Gbeta__Ggamma_-_D2_D3_D4-RIGHT__Complex__GDP_G_protein__D2_D3__D4_-_re90
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re1
pathway component: STATE_TRANSITION_LEFT__DOPA-RIGHT__Dopamine-_re60
pathway component: STATE_TRANSITION_LEFT__DOPA-RIGHT__Dopamine-_re66
pathway component: HETERODIMER_ASSOCIATION_LEFT__GNAZ-_D1_D5-RIGHT__D5_GNAZ_complex-_re79
pathway component: HETERODIMER_ASSOCIATION_LEFT__EPB41-_D2_D3_D4-RIGHT__D2_D3_D4_EBP41_complex-_re73
pathway component: STATE_TRANSITION_LEFT__Gialpha-RIGHT__P-_Gialpha-_re92
pathway component: MODULATION
pathway component: STATE_TRANSITION_LEFT__Dopamine-RIGHT__norepinephrine-_re70
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Gbeta_Ggamma_-_Gialpha-RIGHT__Complex__Gialpha_Gbeta__Ggamma_-_re93
pathway component: HETERODIMER_ASSOCIATION_LEFT__Gbeta_gamma-_Gsalpha-RIGHT__Complex__Gsalpha_Gbeta__Ggamma_-_re86
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re13
pathway component: HETERODIMER_ASSOCIATION_LEFT__D2_D3_D4-_EPB41L2-RIGHT__D3_EPB41L2_complex-_re75
xref: PANTHER Pathway P05912 1
comment: MODEL_NOTES=Panther Pathway: P05912 No pathway definition

D1 D5 s28 sa23 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D1/D5
stoichiometric coefficient: 1.0

D1/D5
type: Protein
entity reference: D1/D5
feature: COMPLEX PARTICIPANT BINDING FEATURE s25 sa25 536
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q811Q2 413
type: UnificationXref
id: Q811Q2
db: uniprot

GTP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dopamine beta-hydroxylase
type: ProteinReference
xref: PTHR10157:SF29
xref: uniprot Q05754 177
organism: Rattus norvegicus

GDP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P27791 62
type: UnificationXref
id: P27791
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F7EBQ5 34
organism: Macaca mulatta

Neuronal synaptobrevin, isoform J
type: ProteinReference
xref: uniprot M9PE71 207
xref: PTHR45701:SF3
organism: Drosophila melanogaster

EPB41L2 s159 sa191 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EPB41L2
stoichiometric coefficient: 1.0

uniprot P22694 61
type: UnificationXref
id: P22694
db: uniprot

uniprot Q5ASG1 239
type: UnificationXref
id: Q5ASG1
db: uniprot

Syntaxin-3
type: ProteinReference
xref: uniprot Q64704 245
xref: PTHR19957:SF34
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re10 628
type: Stoichiometry
physical entity: Protein Phosphatase-1
stoichiometric coefficient: 1.0

uniprot A0A3Q1LYB4 184
type: UnificationXref
id: A0A3Q1LYB4
db: uniprot

Potassium channel subfamily K member 9
type: ProteinReference
xref: PTHR11003:SF75
xref: uniprot Q9NPC2 272
organism: Homo sapiens

uniprot P63215 407
type: UnificationXref
id: P63215
db: uniprot

PARTICIPANT STOICHIOMETRY re10 629
type: Stoichiometry
physical entity: Protein Phosphatase-1
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot E2RBE7 385
organism: Canis lupus familiaris

Catechol O-methyltransferase
type: ProteinReference
xref: PTHR43836:SF3
xref: uniprot P22734 15
organism: Rattus norvegicus

uniprot H2Q2M8 306
type: UnificationXref
id: H2Q2M8
db: uniprot

Complex (GDP/G-protein/ D2/D3/ D4)
type: Complex
component stoichiometry: Ggamma s248 sa254 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s246 sa251 STOICHIOMETRY ID COMPLEX
component stoichiometry: D2 D3 D4 s36 sa59 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gialpha s250 sa250 STOICHIOMETRY ID COMPLEX
component: D2/D3/D4
component: Gialpha
component: Ggamma
component: Gbeta
feature: COMPLEX BINDING FEATURE s33 csa8 529
feature: COMPLEX BINDING FEATURE s33 csa8 531
feature: COMPLEX BINDING FEATURE s33 csa8 525
feature: COMPLEX BINDING FEATURE s33 csa8 527
cellular location: axon terminus

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6XYX9 196
organism: Monodelphis domestica

ncbitaxon 7739 426
type: UnificationXref
id: 7739
db: ncbitaxon

PRKACB isoform 3
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot H2R1G3 41
organism: Pan troglodytes

uniprot P12368 51
type: UnificationXref
id: P12368
db: uniprot

uniprot Q64704 245
type: UnificationXref
id: Q64704
db: uniprot

Filamin-A
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot Q8BTM8 303
organism: Mus musculus

Protein 4.1
type: ProteinReference
xref: uniprot P48193 381
xref: PTHR23280:SF12
organism: Mus musculus

uniprot Q9N0Y0 256
type: UnificationXref
id: Q9N0Y0
db: uniprot

ncbitaxon 10228 424
type: UnificationXref
id: 10228
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 166
xref: PTHR19850:SF27
organism: Homo sapiens

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 57
organism: Homo sapiens

STATE_TRANSITION_LEFT__Dopamine-_Mg2_PLUS_-RIGHT__sa3_degraded-_Mg2_PLUS_-_re61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 666
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 667
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 665
participant stoichiometry: PARTICIPANT STOICHIOMETRY re61 668
left: Mg2+
left: Dopamine
interaction type: STATE_TRANSITION
right: Mg2+
right: sa3_degraded

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62874 165
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62872 163
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62873 164
organism: Homo sapiens

uniprot F6ZSC2 264
type: UnificationXref
id: F6ZSC2
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 167
xref: PTHR19850:SF27
organism: Mus musculus

EPB41L2
type: Protein
entity reference: EPB41L2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P20288 365
type: UnificationXref
id: P20288
db: uniprot

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F6T0T9 32
organism: Xenopus tropicalis

D2 D3 D4 s171 sa198 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

Synaptosomal-associated protein 29
type: ProteinReference
xref: uniprot F6UFJ7 193
xref: PTHR19305:SF9
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Dopamine-_Mg2_PLUS_-RIGHT__sa3_degraded-_Mg2_PLUS_-_re61
controller: MAO

ncbitaxon 81824 422
type: UnificationXref
id: 81824
db: ncbitaxon

Amine oxidase
type: ProteinReference
xref: uniprot H2QYH6 334
xref: PTHR43563:SF5
organism: Pan troglodytes

Amine oxidase
type: ProteinReference
xref: uniprot H2QYH5 333
xref: PTHR43563:SF11
organism: Pan troglodytes

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re14
control type: INHIBITION
controller: Gialpha

CLIC6
type: ProteinReference
xref: P05968
standard name: chloride intracellular channel 6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: chloride intracellular channel 6 Synonym: Synonym not specified Accession: P05968
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.CLIC6
member entity reference: Chloride intracellular channel protein 6
member entity reference: Chloride intracellular channel protein

Gnai3 protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot A9JTC8 275
organism: Danio rerio

uniprot G3N1D1 265
type: UnificationXref
id: G3N1D1
db: uniprot

D2/D3/D4
type: Protein
entity reference: D2/D3/D4
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa59 526
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot A3KMS9 18
type: UnificationXref
id: A3KMS9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62871 162
organism: Bos taurus

Dopa decarboxylase
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot A0A2I3TP36 310
organism: Pan troglodytes

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F1LQT1 87
organism: Rattus norvegicus

uniprot P19627 352
type: UnificationXref
id: P19627
db: uniprot

STATE_TRANSITION_LEFT__K_PLUS__channel-RIGHT__K_PLUS__channel-_re18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 601
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 600
left: K+ channel
interaction type: STATE_TRANSITION
right: K+ channel

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_re65
controller: TH

COMT isoform 1
type: ProteinReference
xref: PTHR43836:SF3
xref: uniprot H2QL91 9
organism: Pan troglodytes

Gsalpha s214 sa227 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gsalpha
stoichiometric coefficient: 1.0

uniprot A0A1D5RJP1 450
type: UnificationXref
id: A0A1D5RJP1
db: uniprot

D(1B) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF136
xref: uniprot P25115 114
organism: Rattus norvegicus

uniprot F1N169 298
type: UnificationXref
id: F1N169
db: uniprot

D(2) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot P60026 370
organism: Pan troglodytes

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

GRB2
type: ProteinReference
xref: P05949
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_NOTES=Long Name: growth factor receptor-bound protein 2 Synonym: Synonym not specified Accession: P05949
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.GRB2
member entity reference: Growth factor receptor-bound protein 2a
member entity reference: Growth factor receptor-bound protein 2

Amine oxidase
type: ProteinReference
xref: uniprot F7D3H3 332
xref: PTHR43563:SF5
organism: Macaca mulatta

uniprot Q13277 233
type: UnificationXref
id: Q13277
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P68182 69
organism: Rattus norvegicus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P68181 68
organism: Mus musculus

uniprot B2RSH2 276
type: UnificationXref
id: B2RSH2
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63044 228
organism: Mus musculus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63045 229
organism: Rattus norvegicus

D(2) dopamine receptor
type: ProteinReference
xref: uniprot P61168 371
xref: PTHR24248:SF87
organism: Mus musculus

D(2) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF87
xref: uniprot P61169 372
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: uniprot Q5E9F0 409
xref: PTHR13809:SF1
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re76 622
type: Stoichiometry
physical entity: FLNA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re76 624
type: Stoichiometry
physical entity: D2/D3-FLNA complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re76 623
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 594
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 595
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

ncbitaxon 39947 321
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q7PXF7 78
type: UnificationXref
id: Q7PXF7
db: uniprot

Vesicle-associated membrane protein 8 (Endobrevin)
type: ProteinReference
xref: uniprot Q7ZUC1 249
xref: PTHR45701:SF7
organism: Danio rerio

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 616
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 615
left: PKA
interaction type: STATE_TRANSITION
right: PKA

uniprot Q9HAV0 172
type: UnificationXref
id: Q9HAV0
db: uniprot

Protein kinase A catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q27687 71
organism: Leishmania major

Os10g0380800 protein
type: ProteinReference
xref: uniprot Q7G6M2 320
organism: Oryza sativa

uniprot G3V8K2 394
type: UnificationXref
id: G3V8K2
db: uniprot

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63027 227
organism: Homo sapiens

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot P63026 226
organism: Bos taurus

Dopamine s7 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

uniprot P12370 53
type: UnificationXref
id: P12370
db: uniprot

uniprot F6PGC8 144
type: UnificationXref
id: F6PGC8
db: uniprot

Potassium channel subfamily K member 9
type: ProteinReference
xref: PTHR11003:SF75
xref: uniprot Q3LS21 269
organism: Mus musculus

uniprot A0A1D5QDW1 180
type: UnificationXref
id: A0A1D5QDW1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re12
controller: AC

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63024 224
organism: Mus musculus

DAT
type: Protein
entity reference: DAT
cellular location: Midbrain DA neuron substantia niagra c5
comment: SPECIES_TYPE=PROTEIN

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot P63025 225
organism: Rattus norvegicus

uniprot P61953 402
type: UnificationXref
id: P61953
db: uniprot

G protein subunit beta 1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot F6PGC8 144
organism: Ornithorhynchus anatinus

Catechol O-methyltransferase
type: ProteinReference
xref: PTHR43836:SF3
xref: uniprot P21964 13
organism: Homo sapiens

Complex (DAT/dopamine)
type: Complex
component stoichiometry: dopamine s102 sa161 STOICHIOMETRY ID COMPLEX
component stoichiometry: DAT s101 sa160 STOICHIOMETRY ID COMPLEX
component: DAT
component: dopamine
feature: COMPLEX BINDING FEATURE s94 csa20 463
feature: COMPLEX BINDING FEATURE s94 csa20 465
cellular location: Midbrain DA neuron substantia niagra c5

PTHR11668:SF300
type: RelationshipXref
id: PTHR11668:SF300
db: PANTHER Family
relationship type: By Homology

VAMP2 isoform 3
type: ProteinReference
xref: uniprot H2RCB8 206
xref: PTHR45701:SF5
organism: Pan troglodytes

Potassium channel subfamily K member 3
type: ProteinReference
xref: PTHR11003:SF138
xref: uniprot O35111 267
organism: Mus musculus

uniprot Q9GNR4 83
type: UnificationXref
id: Q9GNR4
db: uniprot

PTHR24248:SF136
type: RelationshipXref
id: PTHR24248:SF136
db: PANTHER Family
relationship type: By Homology

PTHR24248:SF139
type: RelationshipXref
id: PTHR24248:SF139
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6RIM7 277
organism: Monodelphis domestica

EPB41L2 s184 sa205 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EPB41L2
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase (Fragment)
type: ProteinReference
xref: PTHR11668:SF472
xref: uniprot E9G7U7 427
organism: Daphnia pulex

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR11668:SF300
xref: uniprot A7RVJ0 419
organism: Nematostella vectensis

Amine oxidase [flavin-containing]
type: ProteinReference
xref: uniprot Q6NSN2 342
xref: PTHR43563:SF5
organism: Danio rerio

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P21137 58
organism: Caenorhabditis elegans

G protein subunit beta 4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot E2R2S8 143
organism: Canis lupus familiaris

uniprot G2HIJ9 201
type: UnificationXref
id: G2HIJ9
db: uniprot

uniprot H2Q995 204
type: UnificationXref
id: H2Q995
db: uniprot

PARTICIPANT STOICHIOMETRY re63 659
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re63 658
type: Stoichiometry
physical entity: DAT
stoichiometric coefficient: 1.0

uniprot H9EQQ4 44
type: UnificationXref
id: H9EQQ4
db: uniprot

PARTICIPANT STOICHIOMETRY re8 569
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 6

ATP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re63 661
type: Stoichiometry
physical entity: Complex (DAT/dopamine)
stoichiometric coefficient: 1.0

Protein kinase, cAMP-dependent, catalytic, beta a
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q7T374 80
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re8 570
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

uniprot F7D3H3 332
type: UnificationXref
id: F7D3H3
db: uniprot

PARTICIPANT STOICHIOMETRY re63 660
type: Stoichiometry
physical entity: Na+
stoichiometric coefficient: 1.0

uniprot Q5TZ59 270
type: UnificationXref
id: Q5TZ59
db: uniprot

D(4) dopamine receptor
type: ProteinReference
xref: uniprot P21917 366
xref: PTHR24247:SF205
organism: Homo sapiens

uniprot F6VUT7 195
type: UnificationXref
id: F6VUT7
db: uniprot

Dopamine receptor D1
type: ProteinReference
xref: PTHR24248:SF139
xref: uniprot F6T0L6 105
organism: Monodelphis domestica

D(1B) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF170
xref: uniprot P21918 113
organism: Homo sapiens

uniprot F6ZAV4 90
type: UnificationXref
id: F6ZAV4
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot E2RRD1 24
organism: Canis lupus familiaris

Dopamine receptor D1
type: ProteinReference
xref: PTHR24248:SF139
xref: uniprot F6RJ06 104
organism: Xenopus tropicalis

uniprot P62879 166
type: UnificationXref
id: P62879
db: uniprot

uniprot P51828 95
type: UnificationXref
id: P51828
db: uniprot

D1 D5 s187 sa200 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D1/D5
stoichiometric coefficient: 1.0

uniprot Q9UK08 410
type: UnificationXref
id: Q9UK08
db: uniprot

uniprot Q9SD96 258
type: UnificationXref
id: Q9SD96
db: uniprot

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q9DC51 296
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__DARPP_32-RIGHT__DARPP_32-_re9
controller: CDK5

Gsalpha
type: Protein
feature: Gsalpha s197 sa231 rs1
feature: ACTIVE 17
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24248:SF154
type: RelationshipXref
id: PTHR24248:SF154
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re93 663
type: Stoichiometry
physical entity: Gialpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re93 662
type: Stoichiometry
physical entity: Complex (Gbeta/Ggamma)
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot A8XW88 20
organism: Caenorhabditis briggsae

uniprot H2PZK9 282
type: UnificationXref
id: H2PZK9
db: uniprot

PARTICIPANT STOICHIOMETRY re93 664
type: Stoichiometry
physical entity: Complex (Gialpha/Gbeta/ Ggamma)
stoichiometric coefficient: 1.0

Dopamine beta-hydroxylase
type: ProteinReference
xref: uniprot P15101 176
xref: PTHR10157:SF29
organism: Bos taurus

uniprot H2QXB9 40
type: UnificationXref
id: H2QXB9
db: uniprot

D(1B) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF136
xref: uniprot Q8BLD9 119
organism: Mus musculus

Dopamine receptor D5
type: ProteinReference
xref: PTHR24248:SF136
xref: uniprot F1NTE9 102
organism: Gallus gallus

PTHR11003:SF75
type: RelationshipXref
id: PTHR11003:SF75
db: PANTHER Family
relationship type: By Homology

PTHR24248:SF143
type: RelationshipXref
id: PTHR24248:SF143
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot F6SED9 191
organism: Monodelphis domestica

GO GO:0043679 4
type: UnificationXref
id: GO:0043679
db: GO

uniprot H2QNS5 153
type: UnificationXref
id: H2QNS5
db: uniprot

UNKNOWN_INHIBITION
type: Control
xref: UNKNOWN INHIBITION
controlled: STATE_TRANSITION_LEFT__SNARE_Complex-RIGHT__SNARE_Complex-_re5
control type: INHIBITION
controller: Protein Phosphatase-1

uniprot P19643 335
type: UnificationXref
id: P19643
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__DAT-_Dopamine-_Na_PLUS_-RIGHT__Complex__DAT_dopamine_-_re63
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 661
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 660
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 658
participant stoichiometry: PARTICIPANT STOICHIOMETRY re63 659
left: DAT
left: Dopamine
left: Na+
interaction type: HETERODIMER_ASSOCIATION
right: Complex (DAT/dopamine)

Uncharacterized protein
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot F6YMH2 197
organism: Macaca mulatta

STATE_TRANSITION
type: RelationshipTypeVocabulary

STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_re51
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re51 587
participant stoichiometry: PARTICIPANT STOICHIOMETRY re51 588
left: tyrosine
interaction type: STATE_TRANSITION
right: DOPA

Ddc protein
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot Q7SZR0 323
organism: Danio rerio

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 597
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 596
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A943 199
xref: PTHR45701:SF5
organism: Monodelphis domestica

uniprot Q8BTM8 303
type: UnificationXref
id: Q8BTM8
db: uniprot

uniprot Q7ZUC1 249
type: UnificationXref
id: Q7ZUC1
db: uniprot

uniprot P05132 49
type: UnificationXref
id: P05132
db: uniprot

Gbeta
type: ProteinReference
xref: P05954
standard name: G protein, beta subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.G_beta_
comment: ENTITY_REFERENCE_NOTES= Long Name: G protein, beta subunit Synonym: Guanine nucleotide-binding protein, beta subunit Accession: P05954
member entity reference: G protein subunit beta 2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Uncharacterized protein
member entity reference: G protein subunit beta 1
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Gnb2 protein
member entity reference: Gnb1l protein
member entity reference: GNB4 protein
member entity reference: G protein subunit beta 3

Dopamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s7 sa24 546
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9031 103
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot P48727 435
type: UnificationXref
id: P48727
db: uniprot

CLIC6 s138 sa180 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CLIC6
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_re65
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re65 652
participant stoichiometry: PARTICIPANT STOICHIOMETRY re65 653
left: tyrosine
interaction type: STATE_TRANSITION
right: DOPA

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

D2/D3/D4
type: ProteinReference
xref: P05965
standard name: Dopamine receptor D2,D3 and D4
comment: ENTITY_REFERENCE_NOTES=Long Name: D2/D3/D4 Synonym: D2,D3,D4 Accession: P05965
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.RECEPTOR.D2/D3/D4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: D(4) dopamine receptor
member entity reference: D(2) dopamine receptor
member entity reference: Dopamine receptor D2
member entity reference: D(3) dopamine receptor
member entity reference: Dopamine receptor D3
member entity reference: Uncharacterized protein
member entity reference: Dopamine D2a receptor
member entity reference: Dopamine receptor D4
member entity reference: Dopamine D2c receptor
member entity reference: Dopamine receptor 2 protein transcript variant 1
member entity reference: Dopamine receptor D2-like

PTHR11668:SF377
type: RelationshipXref
id: PTHR11668:SF377
db: PANTHER Family
relationship type: By Homology

PTHR24248:SF118
type: RelationshipXref
id: PTHR24248:SF118
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__DOPA-RIGHT__Dopamine-_re60
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re60 672
participant stoichiometry: PARTICIPANT STOICHIOMETRY re60 673
left: DOPA
interaction type: STATE_TRANSITION
right: Dopamine

ncbitaxon 13616 36
type: UnificationXref
id: 13616
db: ncbitaxon

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 21

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 59

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 595
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 594
left: PKA
interaction type: STATE_TRANSITION
right: PKA

STATE_TRANSITION_LEFT__DOPA-RIGHT__Dopamine-_re66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re66 650
participant stoichiometry: PARTICIPANT STOICHIOMETRY re66 651
left: DOPA
interaction type: STATE_TRANSITION
right: Dopamine

D2/D3-FLNA complex
type: Complex
component stoichiometry: FLNA s165 sa195 STOICHIOMETRY ID COMPLEX
component stoichiometry: D2 D3 D4 s166 sa193 STOICHIOMETRY ID COMPLEX
component: D2/D3/D4
component: FLNA
feature: COMPLEX BINDING FEATURE s164 csa27 559
feature: COMPLEX BINDING FEATURE s164 csa27 557
cellular location: axon terminus

ncbitaxon 3702 255
type: UnificationXref
id: 3702
db: ncbitaxon

EPB41L2 isoform 1
type: ProteinReference
xref: PTHR23280:SF17
xref: uniprot H2QTQ8 131
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__tyrosine-RIGHT__DOPA-_re51
controller: TH

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot A0A2I3S4R3 273
organism: Pan troglodytes

DOPA
type: SmallMolecule
cellular location: Midbrain DA neuron substantia niagra c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A2J8JCK6 377
type: UnificationXref
id: A0A2J8JCK6
db: uniprot

D(4) dopamine receptor
type: ProteinReference
xref: uniprot P51436 369
xref: PTHR24247:SF205
organism: Mus musculus

Dopamine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

SNARE Complex
type: ProteinReference
xref: P05956
comment: ENTITY_REFERENCE_NOTES=Long Name: SNARE Complex Synonym: Synonym not specified Accession: P05956
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.SNARE Complex
member entity reference: Putative SNAP25 homologous protein SNAP30
member entity reference: Vesicle-associated membrane protein 3
member entity reference: Synaptosomal-associated protein 25
member entity reference: Synaptosomal-associated protein 25-A
member entity reference: Synaptosomal-associated protein 29
member entity reference: Vesicle-associated membrane protein 1
member entity reference: Vesicle associated membrane protein 8
member entity reference: Vesicle-associated membrane protein 8
member entity reference: Vesicle associated membrane protein 1
member entity reference: LD03592p
member entity reference: SNAP29 isoform 1
member entity reference: Uncharacterized protein
member entity reference: Vesicle-associated membrane protein 2
member entity reference: Synaptobrevin homolog 2
member entity reference: Synaptobrevin homolog 1
member entity reference: Vesicle-associated membrane protein 8 (Endobrevin)
member entity reference: Syntaxin 3
member entity reference: Synaptosomal-associated protein
member entity reference: Synaptosomal-associated protein 23
member entity reference: t-SNARE protein aex-4
member entity reference: Soluble NSF attachment protein 29
member entity reference: VAMP2 isoform 3
member entity reference: Syntaxin-3
member entity reference: Synaptosomal-associated protein 25-B
member entity reference: SNAP25 homologous protein SNAP29
member entity reference: Synaptobrevin-1
member entity reference: VAMP3 isoform 1
member entity reference: Neuronal synaptobrevin, isoform J
member entity reference: SNAP25 homologous protein SNAP33

ACh
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7EBQ5 34
type: UnificationXref
id: F7EBQ5
db: uniprot

D(1A) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF139
xref: uniprot O77680 110
organism: Macaca mulatta

uniprot A4IGZ2 384
type: UnificationXref
id: A4IGZ2
db: uniprot

AC
type: ProteinReference
xref: P05947
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: adenylate cyclase Synonym: adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase Accession: P05947
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.AC
member entity reference: Adenylate cyclase
member entity reference: Adenylate cyclase type 2
member entity reference: Adenylate cyclase type 7

uniprot B6E506 100
type: UnificationXref
id: B6E506
db: uniprot

uniprot Q9VH76 259
type: UnificationXref
id: Q9VH76
db: uniprot

uniprot P63097 292
type: UnificationXref
id: P63097
db: uniprot

uniprot P62873 164
type: UnificationXref
id: P62873
db: uniprot

K+ channel
type: ProteinReference
xref: P05957
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.ION_CHANNEL.K_super_+_endsuper_ channel
comment: ENTITY_REFERENCE_NOTES=Long Name: K+ channel Synonym: Kcnk3,Potassium channel subfamily K member 3,Potassium channel subfamily K member 9,TASK-1,TASK-3,TWIK Accession: P05957
member entity reference: Potassium channel subfamily K member
member entity reference: Potassium channel subfamily K member 9
member entity reference: Potassium channel subfamily K member 3
member entity reference: Potassium two pore domain channel subfamily K member 9

uniprot P60878 221
type: UnificationXref
id: P60878
db: uniprot

PARTICIPANT STOICHIOMETRY re19 599
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

PTHR24353:SF133
type: RelationshipXref
id: PTHR24353:SF133
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re19 598
type: Stoichiometry
physical entity: K+
stoichiometric coefficient: 1.0

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

EPB41L1
type: Protein
entity reference: EPB41L1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Protein phosphatase 1 regulatory subunit 1B
type: ProteinReference
xref: PTHR15417:SF2
xref: uniprot Q60829 126
organism: Mus musculus

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

uniprot F6SED9 191
type: UnificationXref
id: F6SED9
db: uniprot

uniprot F7HAK5 38
type: UnificationXref
id: F7HAK5
db: uniprot

COMT
type: Protein
entity reference: COMT
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3SL72 418
type: UnificationXref
id: A0A2I3SL72
db: uniprot

Gsalpha
type: Protein
feature: Gsalpha s214 sa227 rs1
feature: COMPLEX PARTICIPANT BINDING FEATURE s214 sa227 550
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9NPC2 272
type: UnificationXref
id: Q9NPC2
db: uniprot

ncbitaxon 9606 14
type: UnificationXref
id: 9606
db: ncbitaxon

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 426

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 395
xref: PTHR13809:SF21
organism: Pan troglodytes

uniprot F6T0T9 32
type: UnificationXref
id: F6T0T9
db: uniprot

PARTICIPANT STOICHIOMETRY re1 596
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 597
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P52287 159
organism: Rattus norvegicus

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot F6UBJ8 192
organism: Xenopus tropicalis

uniprot O95721 213
type: UnificationXref
id: O95721
db: uniprot

uniprot F6Z5I2 198
type: UnificationXref
id: F6Z5I2
db: uniprot

uniprot F6RJ06 104
type: UnificationXref
id: F6RJ06
db: uniprot

By Homology
type: RelationshipTypeVocabulary

PTHR24353:SF128
type: RelationshipXref
id: PTHR24353:SF128
db: PANTHER Family
relationship type: By Homology

uniprot F7FXA9 151
type: UnificationXref
id: F7FXA9
db: uniprot

FLNA
type: Protein
entity reference: FLNA
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

GO GO:0005829 3
type: UnificationXref
id: GO:0005829
db: GO

Synaptosomal-associated protein 23
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot O00161 208
organism: Homo sapiens

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

uniprot P63087 440
type: UnificationXref
id: P63087
db: uniprot

uniprot G5EEN8 202
type: UnificationXref
id: G5EEN8
db: uniprot

uniprot Q86B61 179
type: UnificationXref
id: Q86B61
db: uniprot

SNARE Complex
type: Protein
entity reference: SNARE Complex
feature: SNARE Complex s62 sa16 rs1
feature: ACTIVE 17
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: uniprot A3KMS9 18
xref: PTHR24353:SF82
organism: Danio rerio

D2 D3 D4 s148 sa185 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot B2RSH2 276
organism: Mus musculus

Adenylate cyclase
type: ProteinReference
xref: uniprot A0A1D5RHE7 86
xref: PTHR45627:SF6
organism: Macaca mulatta

uniprot P22612 60
type: UnificationXref
id: P22612
db: uniprot

uniprot P27338 339
type: UnificationXref
id: P27338
db: uniprot

Vesicle associated membrane protein 1
type: ProteinReference
xref: PTHR45701:SF1
xref: uniprot F1PRG8 190
organism: Canis lupus familiaris

uniprot P68182 69
type: UnificationXref
id: P68182
db: uniprot

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6VL43 279
organism: Macaca mulatta

AGAP004613-PA (Fragment)
type: ProteinReference
xref: PTHR24247:SF238
xref: uniprot Q7Q7P1 117
organism: Anopheles gambiae

D2 D3 D4 s137 sa178 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

Protein CBR-BAS-1
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot A8X844 312
organism: Caenorhabditis briggsae

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot P05132 49
xref: PTHR24353:SF82
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P05131 48
organism: Bos taurus

uniprot Q5I080 294
type: UnificationXref
id: Q5I080
db: uniprot

ncbitaxon 6239 59
type: UnificationXref
id: 6239
db: ncbitaxon

ncbitaxon 44689 66
type: UnificationXref
id: 44689
db: ncbitaxon

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__ACh-RIGHT__ACh-_re6
control type: ACTIVATION
controller: SNARE Complex

uniprot Q9Y2J2 382
type: UnificationXref
id: Q9Y2J2
db: uniprot

uniprot E2RBE7 385
type: UnificationXref
id: E2RBE7
db: uniprot

EPB41L1 s155 sa192 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EPB41L1
stoichiometric coefficient: 1.0

uniprot P11171 380
type: UnificationXref
id: P11171
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot E2RJB3 386
organism: Canis lupus familiaris

Amine oxidase
type: ProteinReference
xref: PTHR43563:SF5
xref: uniprot F1PFF8 330
organism: Canis lupus familiaris

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot E2RRA1 22
organism: Canis lupus familiaris

PTHR23506:SF30
type: RelationshipXref
id: PTHR23506:SF30
db: PANTHER Family
relationship type: By Homology

Gialpha
type: Protein
entity reference: Gialpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s251 sa249 504
feature: Gialpha s251 sa249 rs1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot K7AEL3 45
type: UnificationXref
id: K7AEL3
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 388
xref: PTHR13809:SF19
organism: Canis lupus familiaris

SNARE Complex s62 sa16 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY re5 586
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 585
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

UNKNOWN_CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__SNARE_Complex-RIGHT__SNARE_Complex-_re5
controller: PKA

Complex (Gialpha/Gbeta/ Ggamma)
type: Complex
component stoichiometry: Gialpha s242 sa245 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s244 sa247 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s243 sa246 STOICHIOMETRY ID COMPLEX
component: Gialpha
component: Ggamma
component: Gbeta
feature: COMPLEX BINDING FEATURE s241 csa39 485
feature: COMPLEX BINDING FEATURE s241 csa39 481
feature: COMPLEX BINDING FEATURE s241 csa39 483
cellular location: axon terminus

uniprot E9HKA6 428
type: UnificationXref
id: E9HKA6
db: uniprot

uniprot F1QG18 357
type: UnificationXref
id: F1QG18
db: uniprot

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
type: ProteinReference
xref: uniprot Q8MJ46 448
xref: PTHR11668:SF204
organism: Canis lupus familiaris

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: uniprot Q8MJ44 81
xref: PTHR24353:SF82
organism: Canis lupus familiaris

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P13861 55
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot E9GNI4 27
xref: PTHR24353:SF117
organism: Daphnia pulex

UNKNOWN_INHIBITION
type: RelationshipTypeVocabulary

uniprot Q8BW75 343
type: UnificationXref
id: Q8BW75
db: uniprot

Dopamine receptor D1a
type: ProteinReference
xref: uniprot E7F359 101
organism: Danio rerio

HETERODIMER_ASSOCIATION_LEFT__Complex__Gbeta_Ggamma_-_Gialpha-RIGHT__Complex__Gialpha_Gbeta__Ggamma_-_re93
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re93 663
participant stoichiometry: PARTICIPANT STOICHIOMETRY re93 664
participant stoichiometry: PARTICIPANT STOICHIOMETRY re93 662
left: Gialpha
left: Complex (Gbeta/Ggamma)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Gialpha/Gbeta/ Ggamma)

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 139
xref: PTHR19850:SF27
organism: Pan troglodytes

Dopamine D2a receptor
type: ProteinReference
xref: uniprot Q8AWE0 375
xref: PTHR24248:SF87
organism: Danio rerio

uniprot P26769 94
type: UnificationXref
id: P26769
db: uniprot

Na+
type: SmallMolecule
comment: SPECIES_TYPE=ION

uniprot P48461 434
type: UnificationXref
id: P48461
db: uniprot

uniprot F1NTE9 102
type: UnificationXref
id: F1NTE9
db: uniprot

uniprot P51817 67
type: UnificationXref
id: P51817
db: uniprot

uniprot F1NZY0 345
type: UnificationXref
id: F1NZY0
db: uniprot

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
type: ProteinReference
xref: uniprot P63088 441
xref: PTHR11668:SF204
organism: Rattus norvegicus

Vesicle-associated membrane protein 2
type: ProteinReference
xref: PTHR45701:SF5
xref: uniprot Q9N0Y0 256
organism: Macaca mulatta

uniprot H2QFK0 39
type: UnificationXref
id: H2QFK0
db: uniprot

EPB41
type: Protein
entity reference: EPB41
feature: COMPLEX PARTICIPANT BINDING FEATURE s150 sa186 462
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
type: ProteinReference
xref: uniprot P63087 440
xref: PTHR11668:SF204
organism: Mus musculus

Vesicle-associated membrane protein 8
type: ProteinReference
xref: PTHR45701:SF7
xref: uniprot Q3T0Y8 238
organism: Bos taurus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot P36975 219
xref: PTHR19305:SF14
organism: Drosophila melanogaster

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 390
xref: PTHR13809:SF19
organism: Monodelphis domestica

uniprot P60877 220
type: UnificationXref
id: P60877
db: uniprot

Ggamma s209 sa225 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 3
type: ProteinReference
xref: PTHR45701:SF6
xref: uniprot Q15836 234
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Dopamine-_Mg2_PLUS_-RIGHT__sa3_degraded-_Mg2_PLUS_-_re61
controller: COMT

uniprot P05031 316
type: UnificationXref
id: P05031
db: uniprot

uniprot B3S6H7 423
type: UnificationXref
id: B3S6H7
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63097 292
organism: Bos taurus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63096 291
organism: Homo sapiens

Synaptosomal-associated protein 25-B
type: ProteinReference
xref: uniprot Q6PC54 246
xref: PTHR19305:SF5
organism: Danio rerio

VAT2 s261 sa158 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: VAT2
stoichiometric coefficient: 1.0

uniprot F1PJE5 388
type: UnificationXref
id: F1PJE5
db: uniprot

exocytic vesicle
type: CellularLocationVocabulary
xref: GO GO:0070382 2

DBH
type: ProteinReference
xref: P05955
standard name: Dopamine beta-hydroxylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Dopamine beta-hydroxylase Synonym: DA beta-hydroxylase,DBH,Dopamine beta-hydroxylase Accession: P05955
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.DBH
member entity reference: Dopamine beta-hydroxylase
member entity reference: DBH isoform 1
member entity reference: Uncharacterized protein
member entity reference: Tyramine beta-hydroxylase

uniprot F6TUG0 346
type: UnificationXref
id: F6TUG0
db: uniprot

uniprot P62137 438
type: UnificationXref
id: P62137
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot F6TFY2 389
organism: Macaca mulatta

uniprot E9G7U7 427
type: UnificationXref
id: E9G7U7
db: uniprot

uniprot F7CTP1 148
type: UnificationXref
id: F7CTP1
db: uniprot

uniprot Q6PC54 246
type: UnificationXref
id: Q6PC54
db: uniprot

uniprot Q922R0 82
type: UnificationXref
id: Q922R0
db: uniprot

uniprot F7CXD0 149
type: UnificationXref
id: F7CXD0
db: uniprot

Potassium channel subfamily K member
type: ProteinReference
xref: PTHR11003:SF138
xref: uniprot F6ZSC2 264
organism: Monodelphis domestica

uniprot P15101 176
type: UnificationXref
id: P15101
db: uniprot

Ggamma s244 sa247 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re77 619
type: Stoichiometry
physical entity: D3/D4-GRB2 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re77 618
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re77 617
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

AGAP009091-PA
type: ProteinReference
xref: uniprot Q7PW49 322
organism: Anopheles gambiae

uniprot A9JTC8 275
type: UnificationXref
id: A9JTC8
db: uniprot

uniprot Q7SZR0 323
type: UnificationXref
id: Q7SZR0
db: uniprot

uniprot Q61616 116
type: UnificationXref
id: Q61616
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 28

EPB41 s150 sa186 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EPB41
stoichiometric coefficient: 1.0

Filamin-A isoform 2
type: ProteinReference
xref: PTHR38537:SF5
xref: uniprot F7GCM2 301
organism: Macaca mulatta

uniprot P17612 57
type: UnificationXref
id: P17612
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot P63078 405
organism: Mus musculus

uniprot F6T0L6 105
type: UnificationXref
id: F6T0L6
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 404
xref: PTHR13809:SF19
organism: Rattus norvegicus

D1/D5
type: Protein
entity reference: D1/D5
feature: COMPLEX PARTICIPANT BINDING FEATURE s208 sa29 514
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

LD03592p
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot Q9W1I8 260
organism: Drosophila melanogaster

uniprot P63045 229
type: UnificationXref
id: P63045
db: uniprot

STATE_TRANSITION_LEFT__Gsalpha-RIGHT__P-_Gsalpha-_re85
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re85 574
participant stoichiometry: PARTICIPANT STOICHIOMETRY re85 575
participant stoichiometry: PARTICIPANT STOICHIOMETRY re85 576
left: Gsalpha
interaction type: STATE_TRANSITION
right: P
right: Gsalpha

uniprot P63024 224
type: UnificationXref
id: P63024
db: uniprot

uniprot Q17QQ3 235
type: UnificationXref
id: Q17QQ3
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 161
xref: PTHR19850:SF27
organism: Rattus norvegicus

uniprot A8XW88 20
type: UnificationXref
id: A8XW88
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P54311 160
organism: Rattus norvegicus

Putative SNAP25 homologous protein SNAP30
type: ProteinReference
xref: uniprot Q9LMG8 254
organism: Arabidopsis thaliana

uniprot E2R3J3 344
type: UnificationXref
id: E2R3J3
db: uniprot

PARTICIPANT STOICHIOMETRY re14 614
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 150
xref: PTHR19850:SF28
organism: Ornithorhynchus anatinus

PARTICIPANT STOICHIOMETRY re14 613
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

Adenylate cyclase
type: ProteinReference
xref: uniprot F6V001 89
xref: PTHR45627:SF6
organism: Monodelphis domestica

uniprot O88587 11
type: UnificationXref
id: O88587
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7T3D3 295
organism: Danio rerio

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot Q6PH57 170
organism: Danio rerio

uniprot A0A2I3S2W6 123
type: UnificationXref
id: A0A2I3S2W6
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot F1MJV4 88
xref: PTHR45627:SF6
organism: Bos taurus

Complex (GDP/G-protein/ D1/D5)
type: Complex
component stoichiometry: Gbeta s211 sa230 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s213 sa226 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gsalpha s212 sa228 STOICHIOMETRY ID COMPLEX
component stoichiometry: D1 D5 s208 sa29 STOICHIOMETRY ID COMPLEX
component: Ggamma
component: Gsalpha
component: D1/D5
component: Gbeta
feature: COMPLEX BINDING FEATURE s9 csa3 513
feature: COMPLEX BINDING FEATURE s9 csa3 517
feature: COMPLEX BINDING FEATURE s9 csa3 515
feature: COMPLEX BINDING FEATURE s9 csa3 519
cellular location: cytosol

uniprot A0A2I3S4R3 273
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s209 sa225 548
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR19957:SF34
type: RelationshipXref
id: PTHR19957:SF34
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot Q05B25 353
xref: PTHR10218:SF65
organism: Xenopus tropicalis

uniprot P50153 400
type: UnificationXref
id: P50153
db: uniprot

Band 4.1-like protein 3
type: ProteinReference
xref: uniprot Q9Y2J2 382
xref: PTHR23280:SF20
organism: Homo sapiens

uniprot P16520 156
type: UnificationXref
id: P16520
db: uniprot

uniprot H2QE82 379
type: UnificationXref
id: H2QE82
db: uniprot

uniprot Q15836 234
type: UnificationXref
id: Q15836
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR11668:SF300
xref: uniprot A9V782 421
organism: Monosiga brevicollis

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot H2Q995 204
organism: Pan troglodytes

HETERODIMER_ASSOCIATION_LEFT__DOPA-_VAT2-RIGHT__Complex__VAT2_DOPA_-_re69
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 642
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 641
participant stoichiometry: PARTICIPANT STOICHIOMETRY re69 643
left: VAT2
left: DOPA
interaction type: HETERODIMER_ASSOCIATION
right: Complex (VAT2/DOPA)

uniprot O70443 349
type: UnificationXref
id: O70443
db: uniprot

uniprot F6VL43 279
type: UnificationXref
id: F6VL43
db: uniprot

FLNA
type: Protein
entity reference: FLNA
feature: COMPLEX PARTICIPANT BINDING FEATURE s165 sa195 560
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q05754 177
type: UnificationXref
id: Q05754
db: uniprot

uniprot P58027 340
type: UnificationXref
id: P58027
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 240

uniprot Q08462 97
type: UnificationXref
id: Q08462
db: uniprot

Gialpha
type: Protein
entity reference: Gialpha
feature: Gialpha s245 sa248 rs1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3TUD1 139
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

D(1A) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF139
xref: uniprot Q95136 120
organism: Bos taurus

Chloride intracellular channel protein 6
type: ProteinReference
xref: uniprot Q811Q2 413
xref: PTHR45476:SF1
organism: Rattus norvegicus

uniprot H2Q3R5 203
type: UnificationXref
id: H2Q3R5
db: uniprot

uniprot P23977 326
type: UnificationXref
id: P23977
db: uniprot

ncbitaxon 9615 23
type: UnificationXref
id: 9615
db: ncbitaxon

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot A0A2I3SR99 183
xref: PTHR45701:SF7
organism: Pan troglodytes

Synaptosomal-associated protein
type: ProteinReference
xref: PTHR19305:SF4
xref: uniprot A0A1D5QYR9 182
organism: Macaca mulatta

uniprot Q6PH57 170
type: UnificationXref
id: Q6PH57
db: uniprot

uniprot P07516 125
type: UnificationXref
id: P07516
db: uniprot

uniprot P07101 453
type: UnificationXref
id: P07101
db: uniprot

VAT2
type: Protein
entity reference: VAT2
cellular location: exocytic vesicle
comment: SPECIES_TYPE=PROTEIN

AC
type: Protein
entity reference: AC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=ION

ncbitaxon 9913 31
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot P12369 52
type: UnificationXref
id: P12369
db: uniprot

ncbitaxon 45351 420
type: UnificationXref
id: 45351
db: ncbitaxon

uniprot A0A0R4IZT6 416
type: UnificationXref
id: A0A0R4IZT6
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 158
xref: PTHR19850:SF28
organism: Mus musculus

Tyrosine 3-monooxygenase
type: ProteinReference
xref: PTHR11473:SF18
xref: uniprot P04177 452
organism: Rattus norvegicus

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s211 sa230 520
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot M9PE71 207
type: UnificationXref
id: M9PE71
db: uniprot

uniprot Q9UD71 128
type: UnificationXref
id: Q9UD71
db: uniprot

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 168
xref: PTHR19850:SF27
organism: Danio rerio

DARPP-32
type: ProteinReference
xref: P05950
standard name: dopamine- and cAMP- regulated phosphoprotein, 32-KD
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.DARPP-32
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: dopamine- and cAMP- regulated phosphoprotein, 32-KD Synonym: PPP1R1B,protein phosphatase 1, regulatory subunit 1B Accession: P05950
member entity reference: Protein phosphatase 1 regulatory subunit 1B
member entity reference: Protein phosphatase 1 regulatory inhibitor subunit 1B
member entity reference: Protein phosphatase 1 regulatory subunit 1B isoform 1

PTHR11668:SF462
type: RelationshipXref
id: PTHR11668:SF462
db: PANTHER Family
relationship type: By Homology

Gsalpha s212 sa228 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gsalpha
stoichiometric coefficient: 1.0

PTHR11668:SF460
type: RelationshipXref
id: PTHR11668:SF460
db: PANTHER Family
relationship type: By Homology

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 217

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
type: ProteinReference
xref: uniprot Q6NVU2 445
xref: PTHR11668:SF204
organism: Xenopus tropicalis

MODULATION
type: Control
xref: MODULATION
controller: depolarization

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 54

Uncharacterized protein
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot H2Q3R5 203
organism: Pan troglodytes

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 169
xref: PTHR19850:SF31
organism: Mus musculus

uniprot Q5BJ11 168
type: UnificationXref
id: Q5BJ11
db: uniprot

P05969
type: UnificationXref
id: P05969
db: PANTHER Pathway Component

P05968
type: UnificationXref
id: P05968
db: PANTHER Pathway Component

uniprot P12982 432
type: UnificationXref
id: P12982
db: uniprot

P05967
type: UnificationXref
id: P05967
db: PANTHER Pathway Component

P05966
type: UnificationXref
id: P05966
db: PANTHER Pathway Component

K+ channel
type: Protein
entity reference: K+ channel
feature: K PLUS channel s39 sa47 rs1
feature: ACTIVE 17
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot P19086 351
type: UnificationXref
id: P19086
db: uniprot

uniprot F7CT33 325
type: UnificationXref
id: F7CT33
db: uniprot

P05970
type: UnificationXref
id: P05970
db: PANTHER Pathway Component

Fine motor control
type: Pathway

uniprot H2QS18 108
type: UnificationXref
id: H2QS18
db: uniprot

Gialpha s242 sa245 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s215 sa233 540
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P05959
type: UnificationXref
id: P05959
db: PANTHER Pathway Component

P05956
type: UnificationXref
id: P05956
db: PANTHER Pathway Component

P05955
type: UnificationXref
id: P05955
db: PANTHER Pathway Component

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 621
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 620
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

P05958
type: UnificationXref
id: P05958
db: PANTHER Pathway Component

P05957
type: UnificationXref
id: P05957
db: PANTHER Pathway Component

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s210 sa229 552
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P05962
type: UnificationXref
id: P05962
db: PANTHER Pathway Component

uniprot P63044 228
type: UnificationXref
id: P63044
db: uniprot

P05963
type: UnificationXref
id: P05963
db: PANTHER Pathway Component

uniprot P31324 64
type: UnificationXref
id: P31324
db: uniprot

uniprot F7CTZ0 124
type: UnificationXref
id: F7CTZ0
db: uniprot

P05964
type: UnificationXref
id: P05964
db: PANTHER Pathway Component

P05965
type: UnificationXref
id: P05965
db: PANTHER Pathway Component

P05960
type: UnificationXref
id: P05960
db: PANTHER Pathway Component

P05961
type: UnificationXref
id: P05961
db: PANTHER Pathway Component

P05946
type: UnificationXref
id: P05946
db: PANTHER Pathway Component

dopamine s102 sa161 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: dopamine
stoichiometric coefficient: 1.0

P05947
type: UnificationXref
id: P05947
db: PANTHER Pathway Component

P05944
type: UnificationXref
id: P05944
db: PANTHER Pathway Component

P05948
type: UnificationXref
id: P05948
db: PANTHER Pathway Component

P05949
type: UnificationXref
id: P05949
db: PANTHER Pathway Component

Vesicle-associated membrane protein 8
type: ProteinReference
xref: uniprot Q9WUF4 261
xref: PTHR45701:SF7
organism: Rattus norvegicus

Synaptosomal-associated protein 25
type: ProteinReference
xref: uniprot Q5R1X1 241
xref: PTHR19305:SF5
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re66 651
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Ggamma
type: ProteinReference
xref: P05967
standard name: G-protein, gamma subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: G protein, gamma subunit Synonym: Synonym not specified Accession: P05967
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.G_gamma_
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

PARTICIPANT STOICHIOMETRY re66 650
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re75 625
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

D2/D3/D4
type: Protein
entity reference: D2/D3/D4
feature: COMPLEX PARTICIPANT BINDING FEATURE s156 sa189 522
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot O88533 315
organism: Mus musculus

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 33

P05950
type: UnificationXref
id: P05950
db: PANTHER Pathway Component

P05954
type: UnificationXref
id: P05954
db: PANTHER Pathway Component

EPB41
type: Protein
entity reference: EPB41
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re75 626
type: Stoichiometry
physical entity: EPB41L2
stoichiometric coefficient: 1.0

P05953
type: UnificationXref
id: P05953
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re75 627
type: Stoichiometry
physical entity: D3/EPB41L2 complex
stoichiometric coefficient: 1.0

P05952
type: UnificationXref
id: P05952
db: PANTHER Pathway Component

uniprot F6UJE8 278
type: UnificationXref
id: F6UJE8
db: uniprot

P05951
type: UnificationXref
id: P05951
db: PANTHER Pathway Component

Complex (Gbeta/Ggamma)
type: Complex
component stoichiometry: Gbeta s236 sa256 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s254 sa257 STOICHIOMETRY ID COMPLEX
component: Gbeta
component: Ggamma
feature: COMPLEX BINDING FEATURE s253 csa40 479
feature: COMPLEX BINDING FEATURE s253 csa40 477
cellular location: axon terminus

TRIGGER
type: RelationshipTypeVocabulary

uniprot F6V001 89
type: UnificationXref
id: F6V001
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A0A2I3SL72 418
xref: PTHR11668:SF204
organism: Pan troglodytes

D2/D3/D4
type: Protein
entity reference: D2/D3/D4
feature: COMPLEX PARTICIPANT BINDING FEATURE s158 sa190 496
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot E7F359 101
type: UnificationXref
id: E7F359
db: uniprot

MAO
type: ProteinReference
xref: P05963
standard name: Monoamine Oxidase
comment: ENTITY_REFERENCE_NOTES=Long Name: Monoamine Oxidase Synonym: MAO Accession: P05963
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.MAO
member entity reference: Amine oxidase [flavin-containing] A
member entity reference: Amine oxidase
member entity reference: Amine oxidase [flavin-containing] B
member entity reference: Amine oxidase [flavin-containing]

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot P20711 318
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re73 635
type: Stoichiometry
physical entity: D2/D3/D4 EBP41 complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re73 633
type: Stoichiometry
physical entity: EPB41
stoichiometric coefficient: 1.0

uniprot F6YZA3 390
type: UnificationXref
id: F6YZA3
db: uniprot

PARTICIPANT STOICHIOMETRY re73 634
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

uniprot P04897 284
type: UnificationXref
id: P04897
db: uniprot

Complex (D2/D3/ D4/Dopamine)
type: Complex
component stoichiometry: D2 D3 D4 s40 sa49 STOICHIOMETRY ID COMPLEX
component: D2/D3/D4
feature: COMPLEX BINDING FEATURE s29 csa5 533
cellular location: axon terminus

sa3_degraded
type: PhysicalEntity
comment: SPECIES_TYPE=DEGRADED

uniprot P05131 48
type: UnificationXref
id: P05131
db: uniprot

D2 D3 D4 s156 sa189 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

uniprot F6XYX9 196
type: UnificationXref
id: F6XYX9
db: uniprot

uniprot A8X8S6 187
type: UnificationXref
id: A8X8S6
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot E9HKA6 428
xref: PTHR11668:SF300
organism: Daphnia pulex

uniprot Q66II3 122
type: UnificationXref
id: Q66II3
db: uniprot

uniprot P83351 230
type: UnificationXref
id: P83351
db: uniprot

Gialpha s251 sa249 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

D(3) dopamine receptor
type: ProteinReference
xref: uniprot P19020 364
xref: PTHR24248:SF154
organism: Rattus norvegicus

uniprot H2QY46 174
type: UnificationXref
id: H2QY46
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24056:SF46
xref: uniprot A0A1D5QEV2 129
organism: Macaca mulatta

Complex (VAT2/DOPA)
type: Complex
component stoichiometry: VAT2 s261 sa158 STOICHIOMETRY ID COMPLEX
component stoichiometry: DOPA s260 sa159 STOICHIOMETRY ID COMPLEX
component: DOPA
component: VAT2
feature: COMPLEX BINDING FEATURE s259 csa19 509
feature: COMPLEX BINDING FEATURE s259 csa19 511
cellular location: exocytic vesicle

Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot Q6NW93 75
organism: Danio rerio

Gialpha s245 sa248 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot O14649 266
type: UnificationXref
id: O14649
db: uniprot

D2 D3 D4 s158 sa190 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

Vesicle associated membrane protein 8
type: ProteinReference
xref: uniprot E2QUL2 188
xref: PTHR45701:SF7
organism: Canis lupus familiaris

uniprot P54311 160
type: UnificationXref
id: P54311
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot A4IGZ2 384
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR11473:SF18
xref: uniprot A0A1D5RJP1 450
organism: Macaca mulatta

uniprot O45137 314
type: UnificationXref
id: O45137
db: uniprot

uniprot Q5R1X1 241
type: UnificationXref
id: Q5R1X1
db: uniprot

COMT
type: ProteinReference
xref: P05944
standard name: Catechol-O-Methyl Transferase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Catechol-O-Methyl Transferase Synonym: COMT Accession: P05944
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.COMT
member entity reference: Catechol O-methyltransferase
member entity reference: Catechol O-methyltransferase isoform MB-COMT
member entity reference: COMT isoform 1

D(3) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF154
xref: uniprot Q5IS72 373
organism: Pan troglodytes

uniprot F1PFF8 330
type: UnificationXref
id: F1PFF8
db: uniprot

D5_minusEPB41L2 complex
type: Complex
component stoichiometry: D1 D5 s183 sa201 STOICHIOMETRY ID COMPLEX
component stoichiometry: EPB41L2 s184 sa205 STOICHIOMETRY ID COMPLEX
component: D1/D5
component: EPB41L2
feature: COMPLEX BINDING FEATURE s182 csa29 491
feature: COMPLEX BINDING FEATURE s182 csa29 493
cellular location: cytosol

DAT
type: Protein
entity reference: DAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s101 sa160 464
cellular location: Midbrain DA neuron substantia niagra c5
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re4 590
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

uniprot Q92356 250
type: UnificationXref
id: Q92356
db: uniprot

Dopamine
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s255 sa26 538
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re4 591
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ D1/D5/ Dopamine)
stoichiometric coefficient: 1.0

uniprot W4YRI6 84
type: UnificationXref
id: W4YRI6
db: uniprot

CLIC6
type: Protein
entity reference: CLIC6
feature: COMPLEX PARTICIPANT BINDING FEATURE s138 sa180 476
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q8WMS6 449
type: UnificationXref
id: Q8WMS6
db: uniprot

uniprot Q62442 243
type: UnificationXref
id: Q62442
db: uniprot

DISSOCIATION_LEFT__Complex__VAT2_DOPA_-RIGHT__VAT2-_DOPA-_re57
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re57 563
participant stoichiometry: PARTICIPANT STOICHIOMETRY re57 562
participant stoichiometry: PARTICIPANT STOICHIOMETRY re57 561
left: Complex (VAT2/DOPA)
interaction type: DISSOCIATION
right: VAT2
right: DOPA

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F6UJE8 278
organism: Monodelphis domestica

GDP s10 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

Bos taurus
type: BioSource
xref: ncbitaxon 9913 31

Gsalpha s202 sa232 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot H2Q3W7 396
organism: Pan troglodytes

EPB41 isoform 1
type: ProteinReference
xref: uniprot A0A2J8JCK6 377
xref: PTHR23280:SF12
organism: Pan troglodytes

Gialpha s250 sa250 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gialpha
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31324 64
xref: PTHR11635:SF156
organism: Mus musculus

uniprot Q7PSR8 446
type: UnificationXref
id: Q7PSR8
db: uniprot

AGAP008039-PA (Fragment)
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot Q7Q3T7 79
organism: Anopheles gambiae

Gbeta s246 sa251 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P12370 53
organism: Drosophila melanogaster

uniprot F1MJV4 88
type: UnificationXref
id: F1MJV4
db: uniprot

uniprot Q7G6M2 320
type: UnificationXref
id: Q7G6M2
db: uniprot

uniprot P30728 367
type: UnificationXref
id: P30728
db: uniprot

uniprot Q7Q7P1 117
type: UnificationXref
id: Q7Q7P1
db: uniprot

PTHR11999:SF70
type: RelationshipXref
id: PTHR11999:SF70
db: PANTHER Family
relationship type: By Homology

uniprot Q7PW49 322
type: UnificationXref
id: Q7PW49
db: uniprot

Catechol O-methyltransferase
type: ProteinReference
xref: PTHR43836:SF3
xref: uniprot O88587 11
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot F7G7I9 392
organism: Ornithorhynchus anatinus

uniprot F6VS22 106
type: UnificationXref
id: F6VS22
db: uniprot

PTHR45701:SF10
type: RelationshipXref
id: PTHR45701:SF10
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31323 63
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re4 589
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ D1/D5)
stoichiometric coefficient: 1.0

Gbeta s215 sa233 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 103

D(1A) dopamine receptor
type: ProteinReference
xref: PTHR24248:SF139
xref: uniprot Q61616 116
organism: Mus musculus

GNAZ
type: Protein
entity reference: GNAZ
feature: COMPLEX PARTICIPANT BINDING FEATURE s186 sa204 490
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__Dopamine-RIGHT__norepinephrine-_re70
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re70 639
participant stoichiometry: PARTICIPANT STOICHIOMETRY re70 640
left: Dopamine
interaction type: STATE_TRANSITION
right: norepinephrine

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s236 sa256 478
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

DBH isoform 1
type: ProteinReference
xref: PTHR10157:SF29
xref: uniprot H2QY46 174
organism: Pan troglodytes

uniprot P21137 58
type: UnificationXref
id: P21137
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P12369 52
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re85 574
type: Stoichiometry
physical entity: Gsalpha
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P12367 50
xref: PTHR11635:SF153
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12368 51
organism: Rattus norvegicus

EPB41L1
type: Protein
entity reference: EPB41L1
feature: COMPLEX PARTICIPANT BINDING FEATURE s155 sa192 524
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(z) subunit alpha
type: ProteinReference
xref: uniprot P19086 351
xref: PTHR10218:SF65
organism: Homo sapiens

uniprot F1PRG8 190
type: UnificationXref
id: F1PRG8
db: uniprot

tyrosine
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

D2/D3/D4 CLIC6 complex
type: Complex
component stoichiometry: D2 D3 D4 s137 sa178 STOICHIOMETRY ID COMPLEX
component stoichiometry: CLIC6 s138 sa180 STOICHIOMETRY ID COMPLEX
component: D2/D3/D4
component: CLIC6
feature: COMPLEX BINDING FEATURE s136 csa22 473
feature: COMPLEX BINDING FEATURE s136 csa22 475
cellular location: axon terminus

ncbitaxon 5664 26
type: UnificationXref
id: 5664
db: ncbitaxon

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q9VH76 259
xref: PTHR19305:SF14
organism: Drosophila melanogaster

CDK5
type: ProteinReference
xref: P05951
standard name: cyclin-dependent kinase 5
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.GENERIC.CDK5
comment: ENTITY_REFERENCE_NOTES=Long Name: cyclin-dependent kinase 5 Synonym: cell devision kinase 5 Accession: P05951
member entity reference: Uncharacterized protein

Solute carrier family 18 (Vesicular monoamine), member 2
type: ProteinReference
xref: uniprot B0JYP2 305
xref: PTHR23506:SF30
organism: Bos taurus

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s247 sa253 508
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot Q7T374 80
type: UnificationXref
id: Q7T374
db: uniprot

uniprot H2Q2W7 451
type: UnificationXref
id: H2Q2W7
db: uniprot

TH
type: Protein
entity reference: TH
cellular location: Midbrain DA neuron substantia niagra c5
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re85 575
type: Stoichiometry
physical entity: P
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re85 576
type: Stoichiometry
physical entity: Gsalpha
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase alpha-2 isoform
type: ProteinReference
xref: uniprot P12982 432
xref: PTHR11668:SF300
organism: Drosophila melanogaster

uniprot P62871 162
type: UnificationXref
id: P62871
db: uniprot

PTHR11668:SF472
type: RelationshipXref
id: PTHR11668:SF472
db: PANTHER Family
relationship type: By Homology

uniprot Q803H5 171
type: UnificationXref
id: Q803H5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot F6PVT7 145
organism: Monodelphis domestica

DISSOCIATION_LEFT__Complex__VAT2_DOPA_-RIGHT__VAT2-_DOPA-_re68
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re68 644
participant stoichiometry: PARTICIPANT STOICHIOMETRY re68 646
participant stoichiometry: PARTICIPANT STOICHIOMETRY re68 645
left: Complex (VAT2/DOPA)
interaction type: DISSOCIATION
right: VAT2
right: DOPA

uniprot P61168 371
type: UnificationXref
id: P61168
db: uniprot

PARTICIPANT STOICHIOMETRY re67 648
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re67 647
type: Stoichiometry
physical entity: VAT2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re67 649
type: Stoichiometry
physical entity: Complex (VAT2/DOPA)
stoichiometric coefficient: 1.0

uniprot P38400 289
type: UnificationXref
id: P38400
db: uniprot

PTHR15417:SF2
type: RelationshipXref
id: PTHR15417:SF2
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Protein_Phosphatase_1-RIGHT__Protein_Phosphatase_1-_re10
controller: DARPP-32

K+
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=ION

D2/D3/D4
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa55 500
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR24248:SF143
xref: uniprot F7H4T0 361
organism: Macaca mulatta

uniprot O09044 210
type: UnificationXref
id: O09044
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 321

uniprot P62872 163
type: UnificationXref
id: P62872
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__DOPA-RIGHT__Dopamine-_re60
controller: DOPA decarb.

uniprot Q0V7N0 232
type: UnificationXref
id: Q0V7N0
db: uniprot

uniprot P63216 408
type: UnificationXref
id: P63216
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot H2RER5 42
organism: Pan troglodytes

GRB2 s170 sa197 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GRB2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 609
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ D2/D3/ D4/Dopamine)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re15 608
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

uniprot P61169 372
type: UnificationXref
id: P61169
db: uniprot

PARTICIPANT STOICHIOMETRY re15 607
type: Stoichiometry
physical entity: Complex (GDP/G-protein/ D2/D3/ D4)
stoichiometric coefficient: 1.0

PTHR24353:SF67
type: RelationshipXref
id: PTHR24353:SF67
db: PANTHER Family
relationship type: By Homology

Aromatic-L-amino-acid decarboxylase
type: ProteinReference
xref: PTHR11999:SF70
xref: uniprot P14173 317
organism: Rattus norvegicus

uniprot F7FD32 281
type: UnificationXref
id: F7FD32
db: uniprot

CLIC6
type: Protein
entity reference: CLIC6
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot H2QTQ8 131
type: UnificationXref
id: H2QTQ8
db: uniprot

uniprot B0JYP2 305
type: UnificationXref
id: B0JYP2
db: uniprot

Gnb1l protein
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot Q803H5 171
organism: Danio rerio

uniprot P81900 70
type: UnificationXref
id: P81900
db: uniprot

uniprot F7G7I9 392
type: UnificationXref
id: F7G7I9
db: uniprot

Tyrosine hydroxylase 2
type: ProteinReference
xref: uniprot Q1LWZ5 458
xref: PTHR11473:SF19
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re79 604
type: Stoichiometry
physical entity: GNAZ
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re79 605
type: Stoichiometry
physical entity: D1/D5
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re79 606
type: Stoichiometry
physical entity: D5-GNAZ complex
stoichiometric coefficient: 1.0

Vesicle-associated membrane protein 1
type: ProteinReference
xref: uniprot Q63666 244
xref: PTHR45701:SF1
organism: Rattus norvegicus

uniprot F6VM87 194
type: UnificationXref
id: F6VM87
db: uniprot

uniprot P13861 55
type: UnificationXref
id: P13861
db: uniprot

uniprot P22734 15
type: UnificationXref
id: P22734
db: uniprot

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 424

uniprot F6YMH2 197
type: UnificationXref
id: F6YMH2
db: uniprot

uniprot F6Q8V4 412
type: UnificationXref
id: F6Q8V4
db: uniprot

Protein phosphatase 1 regulatory subunit 1B
type: ProteinReference
xref: uniprot Q6J4I0 127
xref: PTHR15417:SF2
organism: Rattus norvegicus

DISSOCIATION_LEFT__Complex__GDP_G_protein__D2_D3__D4_Dopamine_-_GTP-RIGHT__Complex__Gbeta_Ggamma_-_Gialpha-_Complex__D2_D3__D4_Dopamine_-_GDP-_re91
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re91 679
participant stoichiometry: PARTICIPANT STOICHIOMETRY re91 676
participant stoichiometry: PARTICIPANT STOICHIOMETRY re91 678
participant stoichiometry: PARTICIPANT STOICHIOMETRY re91 677
participant stoichiometry: PARTICIPANT STOICHIOMETRY re91 674
participant stoichiometry: PARTICIPANT STOICHIOMETRY re91 675
left: Complex (GDP/G-protein/ D2/D3/ D4/Dopamine)
left: GTP
interaction type: DISSOCIATION
right: Gialpha
right: Complex (Gbeta/Ggamma)
right: Complex (D2/D3/ D4/Dopamine)
right: GDP

uniprot Q5E9F0 409
type: UnificationXref
id: Q5E9F0
db: uniprot

uniprot C3Z434 425
type: UnificationXref
id: C3Z434
db: uniprot

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

uniprot P50150 399
type: UnificationXref
id: P50150
db: uniprot

uniprot Q9WUF4 261
type: UnificationXref
id: Q9WUF4
db: uniprot

PKA
type: Protein
entity reference: PKA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P16912 56
type: UnificationXref
id: P16912
db: uniprot

PARTICIPANT STOICHIOMETRY re65 652
type: Stoichiometry
physical entity: tyrosine
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re65 653
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

PTHR11473:SF15
type: RelationshipXref
id: PTHR11473:SF15
db: PANTHER Family
relationship type: By Homology

uniprot F7GCM2 301
type: UnificationXref
id: F7GCM2
db: uniprot

PTHR11473:SF19
type: RelationshipXref
id: PTHR11473:SF19
db: PANTHER Family
relationship type: By Homology

PTHR11473:SF18
type: RelationshipXref
id: PTHR11473:SF18
db: PANTHER Family
relationship type: By Homology

uniprot F7H6T2 37
type: UnificationXref
id: F7H6T2
db: uniprot

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 251

uniprot Q9LMG8 254
type: UnificationXref
id: Q9LMG8
db: uniprot

uniprot F6ZIZ9 147
type: UnificationXref
id: F6ZIZ9
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__EPB41L1-_D2_D3_D4-RIGHT__D2_D3_EPB41L1_complex-_re74
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re74 630
participant stoichiometry: PARTICIPANT STOICHIOMETRY re74 632
participant stoichiometry: PARTICIPANT STOICHIOMETRY re74 631
left: D2/D3/D4
left: EPB41L1
interaction type: HETERODIMER_ASSOCIATION
right: D2/D3 EPB41L1 complex

Gialpha s252 sa255 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Gbeta s236 sa256 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

uniprot Q64133 341
type: UnificationXref
id: Q64133
db: uniprot

FLNA s165 sa195 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FLNA
stoichiometric coefficient: 1.0

D1/D5
type: ProteinReference
xref: P05948
standard name: Dopamine receptor D1 and D5
comment: ENTITY_REFERENCE_ID_DESC=PNAT.PROTEIN.RECEPTOR.D1/D5
comment: ENTITY_REFERENCE_NOTES=Long Name: D1/D5 Synonym: D1,D5 Accession: P05948
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Dopamine receptor 1
member entity reference: D(1A) dopamine receptor
member entity reference: D(1C) dopamine receptor
member entity reference: Dopamine receptor D1
member entity reference: D(1B) dopamine receptor
member entity reference: Dopamine receptor D5
member entity reference: DOPamine receptor
member entity reference: AGAP004613-PA (Fragment)
member entity reference: Dopamine receptor D1a
member entity reference: DRD1 isoform 1

D1 D5 s27 sa223 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re86 571
type: Stoichiometry
physical entity: Gbeta/gamma
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re86 573
type: Stoichiometry
physical entity: Complex (Gsalpha/Gbeta/ Ggamma)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re86 572
type: Stoichiometry
physical entity: Gsalpha
stoichiometric coefficient: 1.0

uniprot O43491 132
type: UnificationXref
id: O43491
db: uniprot

uniprot Q1LWZ5 458
type: UnificationXref
id: Q1LWZ5
db: uniprot

uniprot Q9BV40 252
type: UnificationXref
id: Q9BV40
db: uniprot

Serine/threonine-protein phosphatase (Fragment)
type: ProteinReference
xref: PTHR11668:SF300
xref: uniprot C3Z434 425
organism: Branchiostoma floridae

uniprot A0A1D5QEV2 129
type: UnificationXref
id: A0A1D5QEV2
db: uniprot

uniprot K7E376 398
type: UnificationXref
id: K7E376
db: uniprot

Synaptosomal-associated protein
type: ProteinReference
xref: uniprot Q28HP6 236
xref: PTHR19305:SF5
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot F7HAK5 38
organism: Macaca mulatta

uniprot P21397 337
type: UnificationXref
id: P21397
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 85

uniprot Q9M0G4 324
type: UnificationXref
id: Q9M0G4
db: uniprot

uniprot H2Q3W7 396
type: UnificationXref
id: H2Q3W7
db: uniprot

Amine oxidase [flavin-containing] A
type: ProteinReference
xref: uniprot P58027 340
xref: PTHR43563:SF11
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q7PSR8 446
xref: PTHR11668:SF300
organism: Anopheles gambiae

PTHR24248:SF170
type: RelationshipXref
id: PTHR24248:SF170
db: PANTHER Family
relationship type: By Homology

uniprot Q96NY7 415
type: UnificationXref
id: Q96NY7
db: uniprot

uniprot F7EPG4 200
type: UnificationXref
id: F7EPG4
db: uniprot

D1/D5
type: Protein
entity reference: D1/D5
feature: COMPLEX PARTICIPANT BINDING FEATURE s183 sa201 492
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P63096 291
type: UnificationXref
id: P63096
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot G3V8K2 394
organism: Rattus norvegicus

uniprot H2Q6V7 431
type: UnificationXref
id: H2Q6V7
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: depolarization
controller: K+ channel

AGAP001384-PA
type: ProteinReference
xref: uniprot Q7PXF7 78
xref: PTHR24353:SF117
organism: Anopheles gambiae

AC
type: Protein
entity reference: AC
feature: ACTIVE 17
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase alpha-3 isoform
type: ProteinReference
xref: uniprot Q05547 442
xref: PTHR11668:SF300
organism: Drosophila melanogaster

uniprot F7ES96 391
type: UnificationXref
id: F7ES96
db: uniprot

Band 4.1-like protein 1
type: ProteinReference
xref: uniprot Q9WTP0 137
xref: PTHR23280:SF24
organism: Rattus norvegicus

uniprot P08752 286
type: UnificationXref
id: P08752
db: uniprot

uniprot F6V922 331
type: UnificationXref
id: F6V922
db: uniprot

Ggamma s247 sa253 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

SNAP29 isoform 1
type: ProteinReference
xref: PTHR19305:SF9
xref: uniprot H2QLA1 205
organism: Pan troglodytes

GRB2
type: Protein
entity reference: GRB2
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PTHR45627:SF9
type: RelationshipXref
id: PTHR45627:SF9
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re13
controller: cAMP

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 66

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR11668:SF460
xref: uniprot Q7ZVR3 447
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re57 563
type: Stoichiometry
physical entity: DOPA
stoichiometric coefficient: 1.0

Tyrosine 3-monooxygenase
type: ProteinReference
xref: PTHR11473:SF18
xref: uniprot P17289 454
organism: Bos taurus

uniprot O35111 267
type: UnificationXref
id: O35111
db: uniprot

PARTICIPANT STOICHIOMETRY re57 561
type: Stoichiometry
physical entity: Complex (VAT2/DOPA)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re57 562
type: Stoichiometry
physical entity: VAT2
stoichiometric coefficient: 1.0

ncbitaxon 10090 12
type: UnificationXref
id: 10090
db: ncbitaxon

Sodium-dependent dopamine transporter
type: ProteinReference
xref: uniprot P23977 326
xref: PTHR11616:SF38
organism: Rattus norvegicus

Mg2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot K7E376 398
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot P61954 403
organism: Rattus norvegicus

uniprot Q9ERB0 253
type: UnificationXref
id: Q9ERB0
db: uniprot

uniprot P00515 46
type: UnificationXref
id: P00515
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot P61952 401
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot P61953 402
organism: Mus musculus

Amine oxidase
type: ProteinReference
xref: uniprot F6V922 331
xref: PTHR43563:SF5
organism: Xenopus tropicalis

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 420

Gsalpha
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s204 sa222 468
feature: Gsalpha s204 sa222 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Ggamma s207 sa224 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

uniprot A7RVJ0 419
type: UnificationXref
id: A7RVJ0
db: uniprot

uniprot P62138 439
type: UnificationXref
id: P62138
db: uniprot

uniprot P63077 404
type: UnificationXref
id: P63077
db: uniprot

Gbeta s249 sa252 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

Complex (GDP/G-protein/ D1/D5/ Dopamine)
type: Complex
component stoichiometry: D1 D5 s28 sa23 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s210 sa229 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gsalpha s214 sa227 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s209 sa225 STOICHIOMETRY ID COMPLEX
component stoichiometry: Dopamine s7 sa24 STOICHIOMETRY ID COMPLEX
component: Dopamine
component: Gsalpha
component: D1/D5
component: Ggamma
component: Gbeta
feature: COMPLEX BINDING FEATURE s3 csa1 549
feature: COMPLEX BINDING FEATURE s3 csa1 543
feature: COMPLEX BINDING FEATURE s3 csa1 547
feature: COMPLEX BINDING FEATURE s3 csa1 551
feature: COMPLEX BINDING FEATURE s3 csa1 545
cellular location: cytosol

G protein subunit alpha z
type: ProteinReference
xref: uniprot H2QLC1 348
xref: PTHR10218:SF65
organism: Pan troglodytes

uniprot A7MBH9 274
type: UnificationXref
id: A7MBH9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re3
controller: Gsalpha

uniprot P04899 285
type: UnificationXref
id: P04899
db: uniprot

PANTHER Pathway P05912 1
type: UnificationXref
id: P05912
db: PANTHER Pathway

uniprot Q9ES08 271
type: UnificationXref
id: Q9ES08
db: uniprot

ncbitaxon 6238 21
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot H2QL91 9
type: UnificationXref
id: H2QL91
db: uniprot

DISSOCIATION_LEFT__GTP-_Complex__GDP_G_protein__D1_D5__Dopamine_-RIGHT__Gsalpha-_Complex__D1_D5__Dopamine_-_Gbeta_gamma-_GDP-_re84
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re84 582
participant stoichiometry: PARTICIPANT STOICHIOMETRY re84 584
participant stoichiometry: PARTICIPANT STOICHIOMETRY re84 583
participant stoichiometry: PARTICIPANT STOICHIOMETRY re84 581
participant stoichiometry: PARTICIPANT STOICHIOMETRY re84 579
participant stoichiometry: PARTICIPANT STOICHIOMETRY re84 580
left: Complex (GDP/G-protein/ D1/D5/ Dopamine)
left: GTP
interaction type: DISSOCIATION
right: Gbeta/gamma
right: Gsalpha
right: GDP
right: Complex (D1/D5/ Dopamine)

D2 D3 D4 s166 sa193 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

STATE_TRANSITION_LEFT__DARPP_32-RIGHT__DARPP_32-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 564
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 565
left: DARPP-32
interaction type: STATE_TRANSITION
right: DARPP-32

uniprot P09172 175
type: UnificationXref
id: P09172
db: uniprot

uniprot H2QYH5 333
type: UnificationXref
id: H2QYH5
db: uniprot

Band 4.1-like protein 1
type: ProteinReference
xref: uniprot Q9H4G0 136
xref: PTHR23280:SF24
organism: Homo sapiens

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s248 sa254 532
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9258 91
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot H2Q1D9 395
type: UnificationXref
id: H2Q1D9
db: uniprot

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s246 sa251 530
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot A9YZQ5 354
type: UnificationXref
id: A9YZQ5
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY re74 630
type: Stoichiometry
physical entity: EPB41L1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re74 631
type: Stoichiometry
physical entity: D2/D3/D4
stoichiometric coefficient: 1.0

TRANSPORT
type: InteractionVocabulary

PARTICIPANT STOICHIOMETRY re74 632
type: Stoichiometry
physical entity: D2/D3 EPB41L1 complex
stoichiometric coefficient: 1.0

uniprot P63214 406
type: UnificationXref
id: P63214
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10157:SF29
xref: uniprot F7HGF9 173
organism: Macaca mulatta

uniprot H2QLA1 205
type: UnificationXref
id: H2QLA1
db: uniprot

PRKACG isoform 1
type: ProteinReference
xref: uniprot H2QXB9 40
xref: PTHR24353:SF137
organism: Pan troglodytes

uniprot P41596 115
type: UnificationXref
id: P41596
db: uniprot

uniprot P51436 369
type: UnificationXref
id: P51436
db: uniprot

uniprot P21917 366
type: UnificationXref
id: P21917
db: uniprot

uniprot Q86ME6 118
type: UnificationXref
id: Q86ME6
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__EPB41L2-_D1_D5-RIGHT__D5_minusEPB41L2_complex-_re78
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 610
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 611
participant stoichiometry: PARTICIPANT STOICHIOMETRY re78 612
left: D1/D5
left: EPB41L2
interaction type: HETERODIMER_ASSOCIATION
right: D5_minusEPB41L2 complex

Adenylate cyclase
type: ProteinReference
xref: uniprot F7DL70 92
xref: PTHR45627:SF9
organism: Macaca mulatta

uniprot F7G3J2 152
type: UnificationXref
id: F7G3J2
db: uniprot

Gbeta s211 sa230 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

uniprot P33328 218
type: UnificationXref
id: P33328
db: uniprot

Protein phosphatase 1 regulatory subunit 1B
type: ProteinReference
xref: PTHR15417:SF2
xref: uniprot Q9UD71 128
organism: Homo sapiens

uniprot E9AFM1 25
type: UnificationXref
id: E9AFM1
db: uniprot

D2/D3/D4 EBP41 complex
type: Complex
component stoichiometry: D2 D3 D4 s148 sa185 STOICHIOMETRY ID COMPLEX
component stoichiometry: EPB41 s150 sa186 STOICHIOMETRY ID COMPLEX
component: D2/D3/D4
component: EPB41
feature: COMPLEX BINDING FEATURE s146 csa24 459
feature: COMPLEX BINDING FEATURE s146 csa24 461
cellular location: axon terminus

MAO
type: Protein
entity reference: MAO
comment: SPECIES_TYPE=PROTEIN

ACh
type: SmallMolecule
cellular location: exocytic vesicle
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Gsalpha
type: Protein
feature: Gsalpha s202 sa232 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P08753 287
type: UnificationXref
id: P08753
db: uniprot

Dopamine s31 sa56 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Dopamine
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7GFT6 430
xref: PTHR11668:SF204
organism: Macaca mulatta

Syntaxin 3A
type: ProteinReference
xref: uniprot Q6PHV0 247
xref: PTHR19957:SF34
organism: Danio rerio

Syntaxin 3
type: ProteinReference
xref: PTHR19957:SF34
xref: uniprot F7EPG4 200
organism: Ornithorhynchus anatinus

uniprot F6WET9 107
type: UnificationXref
id: F6WET9
db: uniprot

EPB41L2
type: Protein
entity reference: EPB41L2
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Monosiga brevicollis
type: BioSource
xref: ncbitaxon 81824 422