Rac family small GTPase 3
type: ProteinReference
xref: uniprot F6THF0 1084
xref: PTHR24072:SF301
organism: Monodelphis domestica

PTHR24356:SF303
type: RelationshipXref
id: PTHR24356:SF303
db: PANTHER Family
relationship type: By Homology

EGFR
type: Protein
entity reference: EGFR
feature: EGFR s67 a87 rs4
feature: EGFR s67 a87 rs2
feature: EGFR s67 a87 rs3
feature: EGFR s67 a87 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q5QN75 926
type: UnificationXref
id: Q5QN75
db: uniprot

14-3-3 protein theta
type: ProteinReference
xref: uniprot P27348 72
xref: PTHR18860:SF3
organism: Homo sapiens

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6SZ66 823
xref: PTHR10048:SF7
organism: Monodelphis domestica

uniprot H2QPP3 549
type: UnificationXref
id: H2QPP3
db: uniprot

uniprot Q7QK56 613
type: UnificationXref
id: Q7QK56
db: uniprot

uniprot Q05513 1201
type: UnificationXref
id: Q05513
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A452DI16 943
organism: Bos taurus

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

MEK1 2 s25 a28 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform
type: ProteinReference
xref: uniprot Q8LF36 482
organism: Arabidopsis thaliana

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__EGFR-RIGHT__EGFR-_r18
controller: EGF

14-3-3 protein sigma
type: ProteinReference
xref: uniprot O70456 70
xref: PTHR18860:SF14
organism: Mus musculus

uniprot A0A452DI16 943
type: UnificationXref
id: A0A452DI16
db: uniprot

STAT
type: Protein
entity reference: STAT
feature: ACTIVE 167
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

c-Cbl
type: ProteinReference
xref: P00544
standard name: Cas-Br-M (murine) ecotropic retroviral transforming oncogene
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.c_minus_Cbl
comment: ENTITY_REFERENCE_NOTES=Long Name: Cas-Br-M (murine) ecotropic retroviral transforming oncogene Synonym: Synonym not specified Accession: P00544
member entity reference: E3 ubiquitin-protein ligase CBL-B
member entity reference: E3 ubiquitin-protein ligase CBL-C
member entity reference: Sli-1 protein
member entity reference: Cbl proto-oncogene
member entity reference: Cbl long isoform
member entity reference: Cbl proto-oncogene B
member entity reference: Cbl proto-oncogene, E3 ubiquitin protein ligase
member entity reference: Uncharacterized protein
member entity reference: E3 ubiquitin-protein ligase CBL
member entity reference: CBL isoform 2
member entity reference: CBLB isoform 4

MAP kinase kinase kinase
type: ProteinReference
xref: uniprot V5ILP2 743
organism: Neurospora crassa

uniprot A4FV00 309
type: UnificationXref
id: A4FV00
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot A4QP33 385
organism: Danio rerio

Mus musculus
type: BioSource
xref: ncbitaxon 10090 71

uniprot F7EFF6 59
type: UnificationXref
id: F7EFF6
db: uniprot

uniprot Q23977 773
type: UnificationXref
id: Q23977
db: uniprot

uniprot Q99683 737
type: UnificationXref
id: Q99683
db: uniprot

uniprot Q39021 258
type: UnificationXref
id: Q39021
db: uniprot

uniprot H2QQ13 551
type: UnificationXref
id: H2QQ13
db: uniprot

MEK1 2 s25 a28 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot F6USY2 708
type: UnificationXref
id: F6USY2
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P28482 247
xref: PTHR24055:SF203
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
type: ProteinReference
xref: PTHR10257:SF4
xref: uniprot Q80W83 479
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 231
organism: Canis lupus familiaris

uniprot V5IKE7 284
type: UnificationXref
id: V5IKE7
db: uniprot

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q4QGB0 925
organism: Leishmania major

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot P92177 109
xref: PTHR18860:SF17
organism: Drosophila melanogaster

Protein sprouty homolog 1
type: DnaReference
xref: PTHR12365:SF10
organism: Macaca mulatta

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot F1MBU9 818
organism: Bos taurus

PTHR48012:SF20
type: RelationshipXref
id: PTHR48012:SF20
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot A4FV68 384
organism: Bos taurus

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

uniprot P41808 250
type: UnificationXref
id: P41808
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q8NEB9 874
organism: Homo sapiens

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1Q118 884
xref: PTHR23113:SF168
organism: Canis lupus familiaris

uniprot Q6ZHA3 1119
type: UnificationXref
id: Q6ZHA3
db: uniprot

PTHR24072:SF300
type: RelationshipXref
id: PTHR24072:SF300
db: PANTHER Family
relationship type: By Homology

uniprot Q13191 297
type: UnificationXref
id: Q13191
db: uniprot

ncbitaxon 237631 4
type: UnificationXref
id: 237631
db: ncbitaxon

uniprot Q925D6 166
type: UnificationXref
id: Q925D6
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 244
organism: Homo sapiens

Protein sprouty homolog 4
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot Q9C004 189
organism: Homo sapiens

uniprot P70296 511
type: UnificationXref
id: P70296
db: uniprot

uniprot P04626 208
type: UnificationXref
id: P04626
db: uniprot

AGR107Cp
type: ProteinReference
xref: uniprot Q74ZU1 138
xref: PTHR18860:SF17
organism: Ashbya gossypii

GRB2-associated-binding protein 2
type: ProteinReference
xref: uniprot Q9Z1S8 1071
xref: PTHR45960:SF1
organism: Mus musculus

Uncharacterized protein
type: DnaReference
organism: Macaca mulatta

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 142

uniprot Q99N57 960
type: UnificationXref
id: Q99N57
db: uniprot

uniprot O43374 356
type: UnificationXref
id: O43374
db: uniprot

14-3-3 protein
type: ProteinReference
xref: uniprot C0H4V6 21
xref: PTHR18860:SF17
organism: Plasmodium falciparum

HBEGF isoform 1
type: ProteinReference
xref: uniprot H2QRM1 552
xref: PTHR10740:SF4
organism: Pan troglodytes

uniprot F7A0H3 53
type: UnificationXref
id: F7A0H3
db: uniprot

uniprot P79996 329
type: UnificationXref
id: P79996
db: uniprot

uniprot Q6Z7L8 1117
type: UnificationXref
id: Q6Z7L8
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot F1MIA2 1150
xref: PTHR22968:SF12
organism: Bos taurus

NRAS protein
type: ProteinReference
xref: uniprot A5D7R9 623
xref: PTHR24070:SF189
organism: Bos taurus

Gab
type: Protein
entity reference: Gab
feature: Gab s64 a85 rs3
feature: Gab s64 a85 rs2
feature: Gab s64 a85 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A2I3TRY9 802
type: UnificationXref
id: A0A2I3TRY9
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q01986 919
organism: Rattus norvegicus

G01511
type: UnificationXref
id: G01511
db: PANTHER Pathway Component

PTHR24356:SF347
type: RelationshipXref
id: PTHR24356:SF347
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q8RZZ3 484
organism: Oryza sativa

Sprouty RTK signaling antagonist 2
type: ProteinReference
xref: uniprot H2Q7P2 180
xref: PTHR12365:SF8
organism: Pan troglodytes

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
type: ProteinReference
xref: uniprot P23595 434
organism: Saccharomyces cerevisiae

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TRE4 968
organism: Pan troglodytes

Sli-1 protein
type: ProteinReference
xref: uniprot Q19019 298
organism: Caenorhabditis elegans

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O42376 1025
organism: Danio rerio

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q9Z1L0 879
xref: PTHR10048:SF33
organism: Rattus norvegicus

uniprot Q02297 569
type: UnificationXref
id: Q02297
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot P79737 679
xref: PTHR24070:SF189
organism: Danio rerio

Epidermal growth factor receptor
type: ProteinReference
xref: PTHR24416:SF91
xref: uniprot P55245 211
organism: Macaca mulatta

uniprot Q9XGU0 1130
type: UnificationXref
id: Q9XGU0
db: uniprot

Phosphatidylinositol 3-kinase piki-1
type: ProteinReference
xref: PTHR10048:SF64
xref: uniprot G5EDY0 837
organism: Caenorhabditis elegans

uniprot A0A3Q2U4X3 592
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

uniprot F1PRG4 596
type: UnificationXref
id: F1PRG4
db: uniprot

uniprot Q4GZ26 864
type: UnificationXref
id: Q4GZ26
db: uniprot

eco ECO:0000303 89
type: UnificationXref
id: ECO:0000303
db: eco

Protein daughter of sevenless
type: ProteinReference
xref: uniprot Q9VZZ9 1070
organism: Drosophila melanogaster

ncbitaxon 6239 84
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot P42337 853
type: UnificationXref
id: P42337
db: uniprot

uniprot A8XZ02 629
type: UnificationXref
id: A8XZ02
db: uniprot

uniprot Q9GPS3 1126
type: UnificationXref
id: Q9GPS3
db: uniprot

uniprot F7FRT9 60
type: UnificationXref
id: F7FRT9
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q6P365 468
xref: PTHR45619:SF42
organism: Xenopus tropicalis

PTHR10194:SF19
type: RelationshipXref
id: PTHR10194:SF19
db: PANTHER Family
relationship type: By Homology

uniprot Q15173 459
type: UnificationXref
id: Q15173
db: uniprot

Protein kinase byr1
type: ProteinReference
xref: uniprot P10506 913
organism: Schizosaccharomyces pombe

Map2k3 protein
type: ProteinReference
xref: uniprot B1H230 152
xref: PTHR48013:SF21
organism: Rattus norvegicus

uniprot P36506 917
type: UnificationXref
id: P36506
db: uniprot

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

Protein kinase C-like 1B
type: ProteinReference
xref: uniprot P34885 1189
xref: PTHR24356:SF240
organism: Caenorhabditis elegans

Pro-neuregulin-2, membrane-bound isoform
type: ProteinReference
xref: uniprot O14511 553
organism: Homo sapiens

uniprot F1PPW0 745
type: UnificationXref
id: F1PPW0
db: uniprot

uniprot H2KYF8 238
type: UnificationXref
id: H2KYF8
db: uniprot

uniprot P97526 361
type: UnificationXref
id: P97526
db: uniprot

Ras protein let-60
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P22981 673
organism: Caenorhabditis elegans

uniprot O14299 718
type: UnificationXref
id: O14299
db: uniprot

Rac family small GTPase 3a
type: ProteinReference
xref: uniprot Q6DGB7 1112
xref: PTHR24072:SF301
organism: Danio rerio

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot F1NYZ2 908
xref: PTHR48013:SF8
organism: Gallus gallus

uniprot P68511 108
type: UnificationXref
id: P68511
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF80
xref: uniprot A0A2I3TDL0 379
organism: Pan troglodytes

uniprot F7G755 420
type: UnificationXref
id: F7G755
db: uniprot

uniprot P62261 99
type: UnificationXref
id: P62261
db: uniprot

uniprot P68254 105
type: UnificationXref
id: P68254
db: uniprot

ncbitaxon 367110 142
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot Q3TTA7 299
type: UnificationXref
id: Q3TTA7
db: uniprot

STAT
type: ProteinReference
xref: P00561
standard name: Signal transducers and activators of transcription
comment: ENTITY_REFERENCE_NOTES=Long Name: signal transducer and activator of transcription Synonym: Acute-phase response factor,Mammary gland factor Accession: P00561
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.STAT
member entity reference: Signal transducer and activator of transcription
member entity reference: Signal transducer and activator of transcription 4
member entity reference: Signal transducer and activator of transcription 2
member entity reference: Signal transducer and activator of transcription 3
member entity reference: Signal transducer and activator of transcription 5B
member entity reference: Signal transducer and transcription activator
member entity reference: Signal transducer and activator of transcription 5A
member entity reference: Signal transducer and activator of transcription 1
member entity reference: Signal transducer and transcription activator 6
member entity reference: Signal transducer and activator of transcription 6
member entity reference: Signal transducer and activator of transcription 1-alpha/beta

uniprot Q7ZW20 144
type: UnificationXref
id: Q7ZW20
db: uniprot

uniprot Q8SSU4 370
type: UnificationXref
id: Q8SSU4
db: uniprot

uniprot P30086 508
type: UnificationXref
id: P30086
db: uniprot

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: uniprot F1PHV7 640
xref: PTHR24070:SF189
organism: Canis lupus familiaris

ERK1-2
type: Protein
entity reference: ERK1-2
feature: ACTIVE 167
feature: ERK1 2 s28 a31 rs1
feature: ERK1 2 s28 a31 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Stress-activated protein kinase jnk-1
type: ProteinReference
xref: uniprot Q8WQG9 332
organism: Caenorhabditis elegans

uniprot P31947 79
type: UnificationXref
id: P31947
db: uniprot

uniprot Q9SJG9 283
type: UnificationXref
id: Q9SJG9
db: uniprot

PTHR10194:SF3
type: RelationshipXref
id: PTHR10194:SF3
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q2TY19 308
organism: Gallus gallus

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q5Z859 268
organism: Oryza sativa

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F6T2X3 976
xref: PTHR11801:SF39
organism: Xenopus tropicalis

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot E7EXT6 594
organism: Danio rerio

NRAS isoform 1
type: ProteinReference
xref: uniprot H2PZQ7 651
xref: PTHR24070:SF189
organism: Pan troglodytes

uniprot F7CW94 981
type: UnificationXref
id: F7CW94
db: uniprot

PTHR10194:SF4
type: RelationshipXref
id: PTHR10194:SF4
db: PANTHER Family
relationship type: By Homology

Sprouty RTK signaling antagonist 2
type: DnaReference
xref: PTHR12365:SF8
organism: Canis lupus familiaris

Probetacellulin
type: ProteinReference
xref: uniprot Q05928 570
organism: Mus musculus

uniprot A0A2I3S2M2 538
type: UnificationXref
id: A0A2I3S2M2
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7DUD6 831
organism: Ornithorhynchus anatinus

uniprot A0A1D5QFG6 537
type: UnificationXref
id: A0A1D5QFG6
db: uniprot

uniprot A0A3Q1LN00 287
type: UnificationXref
id: A0A3Q1LN00
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot A0A3Q1MNG1 151
organism: Bos taurus

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

uniprot D4A779 1054
type: UnificationXref
id: D4A779
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 1039
xref: PTHR24055:SF110
organism: Pan troglodytes

uniprot F7GWP9 421
type: UnificationXref
id: F7GWP9
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot H2QRH7 426
xref: PTHR45619:SF42
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 599
organism: Monodelphis domestica

uniprot E2RQM0 781
type: UnificationXref
id: E2RQM0
db: uniprot

PTHR10194:SF26
type: RelationshipXref
id: PTHR10194:SF26
db: PANTHER Family
relationship type: By Homology

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot E2RL20 945
organism: Canis lupus familiaris

uniprot Q8RZZ3 484
type: UnificationXref
id: Q8RZZ3
db: uniprot

uniprot P68404 1195
type: UnificationXref
id: P68404
db: uniprot

uniprot F7FHD1 237
type: UnificationXref
id: F7FHD1
db: uniprot

GRB2-associated-binding protein 1
type: ProteinReference
xref: PTHR45960:SF5
xref: uniprot A6QLU3 1053
organism: Bos taurus

Receptor tyrosine-protein kinase erbB-3
type: ProteinReference
xref: uniprot Q62799 217
xref: PTHR24416:SF88
organism: Rattus norvegicus

uniprot F4I1B7 37
type: UnificationXref
id: F4I1B7
db: uniprot

PTHR10194:SF21
type: RelationshipXref
id: PTHR10194:SF21
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 269
organism: Mus musculus

Rho-related protein racC
type: ProteinReference
xref: uniprot P34149 1098
xref: PTHR24072:SF310
organism: Dictyostelium discoideum

uniprot A0A2R8Q8S1 620
type: UnificationXref
id: A0A2R8Q8S1
db: uniprot

Rho-related protein racA
type: ProteinReference
xref: uniprot P34147 1096
xref: PTHR24072:SF301
organism: Dictyostelium discoideum

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A8XTZ1 780
organism: Caenorhabditis briggsae

uniprot Q61151 465
type: UnificationXref
id: Q61151
db: uniprot

Rho-related protein racB
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34148 1097
organism: Dictyostelium discoideum

Rho-related protein rac1B
type: ProteinReference
xref: uniprot P34145 1094
xref: PTHR24072:SF281
organism: Dictyostelium discoideum

uniprot Q9WTP2 193
type: UnificationXref
id: Q9WTP2
db: uniprot

Rho-related protein rac1C
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34146 1095
organism: Dictyostelium discoideum

uniprot P45983 324
type: UnificationXref
id: P45983
db: uniprot

Rho-related protein rac1A
type: ProteinReference
xref: uniprot P34144 1093
xref: PTHR24072:SF281
organism: Dictyostelium discoideum

uniprot P48349 90
type: UnificationXref
id: P48349
db: uniprot

uniprot Q60823 612
type: UnificationXref
id: Q60823
db: uniprot

uniprot E1BMG4 1140
type: UnificationXref
id: E1BMG4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9I7L3 527
organism: Drosophila melanogaster

uniprot F7H9J1 711
type: UnificationXref
id: F7H9J1
db: uniprot

PARTICIPANT STOICHIOMETRY r57 1290
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

CBLB isoform 4
type: ProteinReference
xref: uniprot H2QN18 294
xref: PTHR23007:SF3
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r57 1291
type: Stoichiometry
physical entity: Complex (Grb2/SOS)
stoichiometric coefficient: 1.0

uniprot P46734 161
type: UnificationXref
id: P46734
db: uniprot

Mitogen-activated protein kinase FUS3
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot P16892 242
organism: Saccharomyces cerevisiae

uniprot Q9Z1B7 1046
type: UnificationXref
id: Q9Z1B7
db: uniprot

uniprot Q5RKN6 585
type: UnificationXref
id: Q5RKN6
db: uniprot

PTHR10194:SF52
type: RelationshipXref
id: PTHR10194:SF52
db: PANTHER Family
relationship type: By Homology

uniprot C3ZG26 399
type: UnificationXref
id: C3ZG26
db: uniprot

uniprot Q6DV79 1005
type: UnificationXref
id: Q6DV79
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot H2QDN0 712
xref: PTHR24361:SF656
organism: Pan troglodytes

uniprot A9TLC7 1074
type: UnificationXref
id: A9TLC7
db: uniprot

ncbitaxon 10228 395
type: UnificationXref
id: 10228
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r57 1289
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F7BWW9 888
xref: PTHR23113:SF168
organism: Ornithorhynchus anatinus

uniprot P34145 1094
type: UnificationXref
id: P34145
db: uniprot

uniprot Q9WTX4 578
type: UnificationXref
id: Q9WTX4
db: uniprot

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa4 1222
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q39024 260
organism: Arabidopsis thaliana

MODULATION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q39021 258
organism: Arabidopsis thaliana

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q4Q0B0 261
organism: Leishmania major

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
type: ProteinReference
xref: uniprot F6TA21 42
xref: PTHR18860:SF17
organism: Monodelphis domestica

Phosphatidylethanolamine binding protein 4
type: ProteinReference
xref: uniprot H2QVV5 505
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r14 1275
type: Stoichiometry
physical entity: ERK1-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 1274
type: Stoichiometry
physical entity: ERK1-2
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 2
type: ProteinReference
xref: uniprot Q39022 259
organism: Arabidopsis thaliana

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q62074 1209
organism: Mus musculus

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

uniprot E2QUM7 342
type: UnificationXref
id: E2QUM7
db: uniprot

GRB2-related adapter protein
type: ProteinReference
xref: uniprot Q13588 583
xref: PTHR46037:SF2
organism: Homo sapiens

00696
type: UnificationXref
id: MOD:00696
db: mod

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot Q62077 794
organism: Mus musculus

uniprot F6V7D9 413
type: UnificationXref
id: F6V7D9
db: uniprot

uniprot O14511 553
type: UnificationXref
id: O14511
db: uniprot

uniprot E2RJX4 593
type: UnificationXref
id: E2RJX4
db: uniprot

EGFR s67 a87 rs4
type: ModificationFeature
modification type: MODIFICATION FEATURE ubiquitinated
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.192356948147228

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 240
organism: Pan troglodytes

uniprot Q0IIE2 753
type: UnificationXref
id: Q0IIE2
db: uniprot

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot Q60631 586
xref: PTHR46037:SF4
organism: Mus musculus

PTHR46037:SF2
type: RelationshipXref
id: PTHR46037:SF2
db: PANTHER Family
relationship type: By Homology

uniprot F1P859 883
type: UnificationXref
id: F1P859
db: uniprot

PTHR46037:SF1
type: RelationshipXref
id: PTHR46037:SF1
db: PANTHER Family
relationship type: By Homology

uniprot C3YJC1 1075
type: UnificationXref
id: C3YJC1
db: uniprot

uniprot Q39022 259
type: UnificationXref
id: Q39022
db: uniprot

Ras
type: ProteinReference
xref: P00552
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Ras Synonym: Synonym not specified Accession: P00552
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Ras
member entity reference: Ras-like protein 2
member entity reference: RRAS2 protein
member entity reference: Uncharacterized protein
member entity reference: Ras-related protein M-Ras
member entity reference: R-Ras3
member entity reference: Uncharacterized protein rasB
member entity reference: Ras-related protein R-Ras2
member entity reference: Ras-like protein rasB
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: Ras-related protein R-Ras2 isoform a
member entity reference: GTPase HRas
member entity reference: GTPase NRas
member entity reference: Ras-like protein 1
member entity reference: RAS-related 2
member entity reference: Ras-like protein
member entity reference: Uncharacterized protein rasC
member entity reference: Ras-like protein rasG
member entity reference: Protein CBR-RAS-1
member entity reference: Protein ras-2
member entity reference: GTP binding protein
member entity reference: RAS related
member entity reference: RAS related 2
member entity reference: HRAS isoform 2
member entity reference: NRAS protein
member entity reference: Circularly permutated Ras protein 1
member entity reference: NRAS isoform 1
member entity reference: MRAS protein
member entity reference: Protein CBR-LET-60
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: Uncharacterized protein rasG
member entity reference: Related RAS viral (R-ras) oncogene homolog
member entity reference: GTPase HRas isoform 1
member entity reference: Ras-like protein rasD
member entity reference: Ras protein let-60
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: Muscle RAS oncogene homolog
member entity reference: GTPase KRas
member entity reference: Ras-like protein rasS
member entity reference: Uncharacterized protein rasD
member entity reference: Protein CBR-RAS-2
member entity reference: Ras-related protein R-Ras
member entity reference: Predicted protein
member entity reference: Ras-like protein rasC
member entity reference: Uncharacterized protein rasS
member entity reference: AGAP002219-PA
member entity reference: NRAS proto-oncogene, GTPase
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: Protein ras-1

uniprot F6WA79 47
type: UnificationXref
id: F6WA79
db: uniprot

PTHR24070:SF206
type: RelationshipXref
id: PTHR24070:SF206
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot Q99759 738
xref: PTHR24361:SF656
organism: Homo sapiens

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 390

uniprot Q07890 896
type: UnificationXref
id: Q07890
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A1D5Q6M6 376
xref: PTHR10257:SF6
organism: Macaca mulatta

uniprot H2QRM1 552
type: UnificationXref
id: H2QRM1
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__EGFR-RIGHT__EGFR-_r56
control type: INHIBITION
controller: Spry

ncbitaxon 9031 124
type: UnificationXref
id: 9031
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF60
xref: uniprot F1MHW1 344
organism: Bos taurus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF6
xref: uniprot F6XL57 416
organism: Ornithorhynchus anatinus

uniprot F6QUW1 885
type: UnificationXref
id: F6QUW1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RKIP-RIGHT__RKIP-_r11
controller: PKC

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7H808 422
xref: PTHR45619:SF42
organism: Macaca mulatta

Mitogen activated protein kinase kinase 2
type: ProteinReference
xref: uniprot V5ILY0 934
organism: Neurospora crassa

JNK1-3
type: ProteinReference
xref: P00545
standard name: C-jun-amino-terminal kinase 1, 2, and 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.JNK1_minus_3
comment: ENTITY_REFERENCE_NOTES=Long Name: C-jun-amino-terminal kinase 1, 2, and 3 Synonym: SAPK,stress-activated protein kinase Accession: P00545
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase
member entity reference: GLH-binding kinase 1
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Stress-activated protein kinase jnk-1
member entity reference: Stress-activated protein kinase JNK

uniprot Q6PD28 470
type: UnificationXref
id: Q6PD28
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot D4A229 1138
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r22 1248
type: Stoichiometry
physical entity: MEKK1-5
stoichiometric coefficient: 1.0

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot K7CBH8 1170
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r22 1247
type: Stoichiometry
physical entity: MEKK1-5
stoichiometric coefficient: 1.0

uniprot Q5K8Z6 125
type: UnificationXref
id: Q5K8Z6
db: uniprot

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6YAB9 1019
xref: PTHR24055:SF110
organism: Monodelphis domestica

uniprot Q60631 586
type: UnificationXref
id: Q60631
db: uniprot

uniprot Q15139 1204
type: UnificationXref
id: Q15139
db: uniprot

uniprot P31751 608
type: UnificationXref
id: P31751
db: uniprot

Disabled homolog 2-interacting protein
type: ProteinReference
xref: uniprot Q3UHC7 364
xref: PTHR10194:SF26
organism: Mus musculus

uniprot Q9PTL2 190
type: UnificationXref
id: Q9PTL2
db: uniprot

uniprot Q94124 1124
type: UnificationXref
id: Q94124
db: uniprot

uniprot Q6PF93 868
type: UnificationXref
id: Q6PF93
db: uniprot

MAP3K2 isoform 1
type: ProteinReference
xref: PTHR24361:SF342
xref: uniprot H2QIN7 713
organism: Pan troglodytes

Rho family GTPase
type: ProteinReference
xref: uniprot C4M8K6 1079
xref: PTHR24072:SF281
organism: Entamoeba histolytica

Multifunctional chaperone, putative
type: ProteinReference
xref: uniprot B7Q5I4 19
xref: PTHR18860:SF17
organism: Ixodes scapularis

PTHR10194:SF60
type: RelationshipXref
id: PTHR10194:SF60
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XT65 910
xref: PTHR48013:SF5
organism: Monodelphis domestica

ncbitaxon 5759 24
type: UnificationXref
id: 5759
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QS62 321
organism: Pan troglodytes

Putative odorant-binding protein A5
type: ProteinReference
xref: uniprot P54185 510
xref: PTHR11362:SF131
organism: Drosophila melanogaster

Serine/threonine-protein kinase STE11
type: ProteinReference
xref: uniprot P23561 722
organism: Saccharomyces cerevisiae

Serine/threonine-protein kinase BCK1/SLK1/SSP31
type: ProteinReference
xref: uniprot Q01389 726
organism: Saccharomyces cerevisiae

uniprot F6WV79 314
type: UnificationXref
id: F6WV79
db: uniprot

uniprot F7HS52 1058
type: UnificationXref
id: F7HS52
db: uniprot

Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
type: ProteinReference
xref: uniprot D3ZTF6 808
xref: PTHR10048:SF28
organism: Rattus norvegicus

Protein ras-2
type: ProteinReference
xref: uniprot Q01387 681
organism: Neurospora crassa

…
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

uniprot Q6EUP4 134
type: UnificationXref
id: Q6EUP4
db: uniprot

Mitogenesis Differentiation
type: Pathway

MKK4,7
type: Protein
entity reference: MKK4,7
feature: ACTIVE 167
feature: MKK4,7 s48 a62 rs2
feature: MKK4,7 s48 a62 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase akt-2
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q9XTG7 617
organism: Caenorhabditis elegans

uniprot D3ZFJ0 807
type: UnificationXref
id: D3ZFJ0
db: uniprot

uniprot P24583 1185
type: UnificationXref
id: P24583
db: uniprot

Ras-like protein
type: ProteinReference
xref: uniprot Q12526 683
xref: PTHR24070:SF17
organism: Emericella nidulans

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A4FV00 309
organism: Bos taurus

uniprot F6RIX6 40
type: UnificationXref
id: F6RIX6
db: uniprot

uniprot F5HM75 499
type: UnificationXref
id: F5HM75
db: uniprot

Complex (Grb2/SOS)
type: Complex
component stoichiometry: SOS s139 sa2 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s138 sa1 STOICHIOMETRY ID COMPLEX
component: Grb2
component: SOS
feature: COMPLEX BINDING FEATURE s137 a106 1227
feature: COMPLEX BINDING FEATURE s137 a106 1225
cellular location: cytosol

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F7CYE3 318
organism: Xenopus tropicalis

uniprot D4A3U7 1014
type: UnificationXref
id: D4A3U7
db: uniprot

Ras-like protein 1
type: ProteinReference
xref: uniprot Q59XU5 687
xref: PTHR24070:SF17
organism: Candida albicans

EGFR s67 a87 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.271642349477033
comment: MODIFICATION_RESIDUE_NAME=

uniprot P52564 162
type: UnificationXref
id: P52564
db: uniprot

uniprot F7BS95 54
type: UnificationXref
id: F7BS95
db: uniprot

Equus caballus
type: BioSource
xref: ncbitaxon 9796 545

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: uniprot Q5RKN6 585
xref: PTHR46037:SF4
organism: Danio rerio

uniprot E1BIN8 541
type: UnificationXref
id: E1BIN8
db: uniprot

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: PTHR48013:SF12
xref: uniprot A0A2I3RB56 150
organism: Pan troglodytes

uniprot P42339 855
type: UnificationXref
id: P42339
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot P46734 161
organism: Homo sapiens

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot Q8AXX6 480
organism: Danio rerio

uniprot E2QU83 1080
type: UnificationXref
id: E2QU83
db: uniprot

SHC s56 a73 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

MRAS protein
type: ProteinReference
xref: uniprot A5D7L6 622
organism: Bos taurus

PIK3C2A isoform 5
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot H2Q383 839
organism: Pan troglodytes

Receptor protein-tyrosine kinase
type: ProteinReference
xref: uniprot F7GAV2 202
xref: PTHR24416:SF90
organism: Ornithorhynchus anatinus

uniprot Q7PWN1 519
type: UnificationXref
id: Q7PWN1
db: uniprot

uniprot F7CYE3 318
type: UnificationXref
id: F7CYE3
db: uniprot

PTHR12874:SF9
type: RelationshipXref
id: PTHR12874:SF9
db: PANTHER Family
relationship type: By Homology

uniprot Q13480 1062
type: UnificationXref
id: Q13480
db: uniprot

uniprot H2QNG3 652
type: UnificationXref
id: H2QNG3
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot F1MY82 1151
organism: Bos taurus

uniprot F7HLC7 836
type: UnificationXref
id: F7HLC7
db: uniprot

uniprot F1N795 345
type: UnificationXref
id: F1N795
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot A0A3Q2U4X3 592
organism: Gallus gallus

uniprot P68255 106
type: UnificationXref
id: P68255
db: uniprot

uniprot F7BRK5 946
type: UnificationXref
id: F7BRK5
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot F6ZTS0 1020
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6USY2 708
xref: PTHR24361:SF656
organism: Monodelphis domestica

uniprot Q02956 1199
type: UnificationXref
id: Q02956
db: uniprot

uniprot Q80XL1 300
type: UnificationXref
id: Q80XL1
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot H2QDQ1 1167
organism: Pan troglodytes

RasGAP-activating-like protein 1
type: ProteinReference
xref: PTHR10194:SF3
xref: uniprot Q9Z268 373
organism: Mus musculus

Neurofibromin
type: ProteinReference
xref: PTHR10194:SF60
xref: uniprot P21359 358
organism: Homo sapiens

uniprot F7D8W9 546
type: UnificationXref
id: F7D8W9
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF39
xref: uniprot A0A140T878 962
organism: Bos taurus

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

uniprot P34144 1093
type: UnificationXref
id: P34144
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HPR8 746
xref: PTHR10337:SF2
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P19174 790
organism: Homo sapiens

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot Q6RUV5 1116
xref: PTHR24072:SF105
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A1D5QE27 799
organism: Macaca mulatta

Uncharacterized protein rasD
type: ProteinReference
xref: uniprot F0ZB76 635
xref: PTHR24070:SF418
organism: Dictyostelium purpureum

SOS s139 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

uniprot H2QHF1 63
type: UnificationXref
id: H2QHF1
db: uniprot

Receptor protein-tyrosine kinase
type: ProteinReference
xref: uniprot A0A2I3RF60 195
xref: PTHR24416:SF90
organism: Pan troglodytes

Sprouty RTK signaling antagonist 4
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot H2QRP3 182
organism: Pan troglodytes

uniprot F7AGV5 156
type: UnificationXref
id: F7AGV5
db: uniprot

EGFR s67 a87 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.29874869898594847
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q13362 456
type: UnificationXref
id: Q13362
db: uniprot

uniprot Q3U6Q4 863
type: UnificationXref
id: Q3U6Q4
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K5T3 798
organism: Rattus norvegicus

uniprot P47809 772
type: UnificationXref
id: P47809
db: uniprot

uniprot A8WWD7 907
type: UnificationXref
id: A8WWD7
db: uniprot

Apoptotic signal-regulating kinase 1, isoform C
type: ProteinReference
xref: uniprot Q9VDS9 740
organism: Drosophila melanogaster

Ras homolog family member J
type: ProteinReference
xref: uniprot Q5TZD5 1109
organism: Danio rerio

eco ECO:0000353 895
type: UnificationXref
id: ECO:0000353
db: eco

CEN-like protein 2, putative, expressed
type: ProteinReference
xref: uniprot Q53Q71 517
organism: Oryza sativa

uniprot H2RB91 1061
type: UnificationXref
id: H2RB91
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NVA9 498
organism: Gallus gallus

uniprot P13696 507
type: UnificationXref
id: P13696
db: uniprot

PARTICIPANT STOICHIOMETRY r56 1294
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 1295
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6U7A6 412
xref: PTHR45619:SF42
organism: Monodelphis domestica

uniprot Q96S96 524
type: UnificationXref
id: Q96S96
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r4
controller: Complex (EGFR/PLC_gamma/ STAT/PI3K/ SHC/Gab/ Grb2/SOS/ GAP)

Ras GTPase-activating protein nGAP
type: ProteinReference
xref: uniprot Q9UJF2 371
xref: PTHR10194:SF52
organism: Homo sapiens

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
type: ProteinReference
xref: uniprot F7DGH9 56
xref: PTHR18860:SF16
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 236
organism: Monodelphis domestica

Rac family small GTPase 1b
type: ProteinReference
xref: uniprot Q29RC5 1106
xref: PTHR24072:SF105
organism: Danio rerio

MAP kinase kinase 4, isoform A
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot O61444 770
organism: Drosophila melanogaster

Mitogen-activated protein kinase p38b
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot O61443 1026
organism: Drosophila melanogaster

uniprot P97538 680
type: UnificationXref
id: P97538
db: uniprot

Phosphatidylethanolamine-binding protein 1
type: ProteinReference
xref: PTHR11362:SF10
xref: uniprot P31044 509
organism: Rattus norvegicus

EGFR s67 a87 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.8660799645249737

PANTHER Pathway P00018 1
type: UnificationXref
id: P00018
db: PANTHER Pathway

uniprot P48463 439
type: UnificationXref
id: P48463
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF42
xref: uniprot Q567Y8 463
organism: Danio rerio

uniprot A6QLU3 1053
type: UnificationXref
id: A6QLU3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r6
controller: Complex (EGFR/PLC_gamma/ STAT/PI3K/ SHC/Gab/ Grb2/SOS/ GAP)

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7GEK1 603
xref: PTHR24356:SF190
organism: Monodelphis domestica

uniprot G5EDY0 837
type: UnificationXref
id: G5EDY0
db: uniprot

Neuregulin 3
type: ProteinReference
xref: uniprot A0A2I3S2M2 538
organism: Pan troglodytes

ncbitaxon 7955 31
type: UnificationXref
id: 7955
db: ncbitaxon

RAS protein activator-like 2
type: ProteinReference
xref: uniprot A0A0G2JTA7 335
xref: PTHR10194:SF52
organism: Rattus norvegicus

uniprot F6TPY3 411
type: UnificationXref
id: F6TPY3
db: uniprot

uniprot P08487 787
type: UnificationXref
id: P08487
db: uniprot

14-3-3 zeta
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot E9H1W5 32
organism: Daphnia pulex

uniprot H9FVU5 841
type: UnificationXref
id: H9FVU5
db: uniprot

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 226

Phosphoinositide-3-kinase regulatory subunit 5
type: ProteinReference
xref: uniprot E2RLD1 815
xref: PTHR15593:SF2
organism: Canis lupus familiaris

Ras-like protein rasB
type: ProteinReference
xref: PTHR24070:SF206
xref: uniprot P32252 674
organism: Dictyostelium discoideum

uniprot Q04917 111
type: UnificationXref
id: Q04917
db: uniprot

AGAP000018-PA
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q7QEJ7 871
organism: Anopheles gambiae

Ras-like protein rasS
type: ProteinReference
xref: uniprot P32254 676
xref: PTHR24070:SF380
organism: Dictyostelium discoideum

uniprot F6Y841 829
type: UnificationXref
id: F6Y841
db: uniprot

Ras-like protein rasC
type: ProteinReference
xref: PTHR24070:SF251
xref: uniprot P32253 675
organism: Dictyostelium discoideum

SPRY
type: RnaRegion
cellular location: cytosol
comment: SPECIES_TYPE=RNA

Epidermal growth factor receptor
type: ProteinReference
xref: PTHR24416:SF91
xref: uniprot P00533 206
organism: Homo sapiens

Proepiregulin
type: ProteinReference
xref: uniprot O14944 554
organism: Homo sapiens

14-3-3-like protein GF14-F
type: ProteinReference
xref: PTHR18860:SF103
xref: uniprot Q06967 112
organism: Oryza sativa

PEBP1 isoform 1
type: ProteinReference
xref: uniprot H2Q6Z4 504
xref: PTHR11362:SF109
organism: Pan troglodytes

uniprot F0ZN94 1081
type: UnificationXref
id: F0ZN94
db: uniprot

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: uniprot P51692 996
xref: PTHR11801:SF39
organism: Homo sapiens

uniprot F0ZDJ1 402
type: UnificationXref
id: F0ZDJ1
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot A0A0G2JTA1 374
organism: Rattus norvegicus

uniprot F1PAY3 973
type: UnificationXref
id: F1PAY3
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q10R90 455
organism: Oryza sativa

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot E2QZT7 29
organism: Canis lupus familiaris

uniprot Q552M5 900
type: UnificationXref
id: Q552M5
db: uniprot

uniprot F7HPR8 746
type: UnificationXref
id: F7HPR8
db: uniprot

uniprot Q7ZVI3 1121
type: UnificationXref
id: Q7ZVI3
db: uniprot

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: uniprot P22543 850
xref: PTHR10048:SF7
organism: Saccharomyces cerevisiae

uniprot F6R8N3 600
type: UnificationXref
id: F6R8N3
db: uniprot

Mitogen-activated protein kinase 16
type: ProteinReference
xref: uniprot Q8W4J2 275
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot E1BMX0 631
organism: Bos taurus

SHC-transforming protein 3
type: ProteinReference
xref: uniprot Q92529 758
xref: PTHR10337:SF4
organism: Homo sapiens

uniprot F1P630 311
type: UnificationXref
id: F1P630
db: uniprot

uniprot A0A1D5Q575 168
type: UnificationXref
id: A0A1D5Q575
db: uniprot

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 24

Ras-related protein R-Ras
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot D3Z8L7 630
organism: Rattus norvegicus

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

MEKK1 5 s49 a61 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot P56974 567
type: UnificationXref
id: P56974
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot F1PXD3 154
xref: PTHR48013:SF21
organism: Canis lupus familiaris

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9Z1B7 1046
xref: PTHR24055:SF107
organism: Mus musculus

uniprot Q9WUI1 1045
type: UnificationXref
id: Q9WUI1
db: uniprot

uniprot Q3T0N5 1036
type: UnificationXref
id: Q3T0N5
db: uniprot

uniprot F7BD74 157
type: UnificationXref
id: F7BD74
db: uniprot

uniprot Q93WI9 523
type: UnificationXref
id: Q93WI9
db: uniprot

uniprot P21860 210
type: UnificationXref
id: P21860
db: uniprot

uniprot F1MYJ4 595
type: UnificationXref
id: F1MYJ4
db: uniprot

p38
type: Protein
entity reference: p38
feature: p38 s53 a66 rs1
feature: p38 s53 a66 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

14-3-3-like protein GF14-E
type: ProteinReference
xref: uniprot Q6EUP4 134
xref: PTHR12874:SF9
organism: Oryza sativa

uniprot P10686 788
type: UnificationXref
id: P10686
db: uniprot

uniprot F7F5K9 646
type: UnificationXref
id: F7F5K9
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P48463 439
xref: PTHR45619:SF44
organism: Gallus gallus

uniprot Q17941 611
type: UnificationXref
id: Q17941
db: uniprot

uniprot A7F871 625
type: UnificationXref
id: A7F871
db: uniprot

Protein ras-1
type: ProteinReference
xref: uniprot P22126 672
xref: PTHR24070:SF17
organism: Neurospora crassa

RCG41526, isoform CRA_a
type: DnaReference
xref: PTHR12365:SF10
organism: Rattus norvegicus

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 43

MEKK1 5 s49 a61 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Rac
type: Protein
entity reference: Rac
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein FLOWERING LOCUS T
type: ProteinReference
xref: uniprot Q9SXZ2 529
organism: Arabidopsis thaliana

Sprouty RTK signaling antagonist 2
type: ProteinReference
xref: uniprot E2RGU9 173
xref: PTHR12365:SF8
organism: Canis lupus familiaris

Protein kinase C eta type
type: ProteinReference
xref: uniprot E2RGU7 1145
xref: PTHR24356:SF192
organism: Canis lupus familiaris

uniprot F1MBU9 818
type: UnificationXref
id: F1MBU9
db: uniprot

uniprot Q380Z0 462
type: UnificationXref
id: Q380Z0
db: uniprot

uniprot P22981 673
type: UnificationXref
id: P22981
db: uniprot

uniprot P32252 674
type: UnificationXref
id: P32252
db: uniprot

IP07080p
type: ProteinReference
xref: uniprot Q29QL9 514
organism: Drosophila melanogaster

Dual specificity mitogen-activated protein kinase kinase hemipterous
type: ProteinReference
xref: uniprot Q23977 773
organism: Drosophila melanogaster

uniprot F6SZ66 823
type: UnificationXref
id: F6SZ66
db: uniprot

Protein CBG05964
type: ProteinReference
xref: uniprot A8X180 497
organism: Caenorhabditis briggsae

uniprot P34730 80
type: UnificationXref
id: P34730
db: uniprot

ncbitaxon 9606 73
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot F6X958 415
type: UnificationXref
id: F6X958
db: uniprot

Related RAS viral (R-ras) oncogene homolog
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot Q2TBH2 685
organism: Bos taurus

uniprot F7B762 544
type: UnificationXref
id: F7B762
db: uniprot

PTHR24072:SF281
type: RelationshipXref
id: PTHR24072:SF281
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 316
organism: Macaca mulatta

uniprot P16892 242
type: UnificationXref
id: P16892
db: uniprot

MAP kinase kinase kinase wis4
type: ProteinReference
xref: uniprot O14299 718
organism: Schizosaccharomyces pombe

uniprot F1PXS7 231
type: UnificationXref
id: F1PXS7
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F7G3I5 834
organism: Monodelphis domestica

PTHR24070:SF245
type: RelationshipXref
id: PTHR24070:SF245
db: PANTHER Family
relationship type: By Homology

uniprot K7ALD7 653
type: UnificationXref
id: K7ALD7
db: uniprot

14-3-3 protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot Q5ZKC9 130
organism: Gallus gallus

KNOWN_TRANSITION_OMITTED_LEFT__MEKK1_5-RIGHT__MEKK1_5-_r22
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1248
participant stoichiometry: PARTICIPANT STOICHIOMETRY r22 1247
left: MEKK1-5
interaction type: KNOWN_TRANSITION_OMITTED
right: MEKK1-5

SHC (Src homology 2 domain containing) transforming protein 1
type: ProteinReference
xref: uniprot H2R8L2 747
xref: PTHR10337:SF2
organism: Pan troglodytes

E3 ubiquitin-protein ligase CBL
type: ProteinReference
xref: uniprot A0A1D5RFE7 286
xref: PTHR23007:SF5
organism: Macaca mulatta

Sprouty homolog 4 (Drosophila)
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot F1QZW4 177
organism: Danio rerio

uniprot A8X180 497
type: UnificationXref
id: A8X180
db: uniprot

Protein CBR-RAS-1
type: ProteinReference
xref: uniprot A8XZ02 629
organism: Caenorhabditis briggsae

uniprot Q8WYR1 875
type: UnificationXref
id: Q8WYR1
db: uniprot

uniprot P40977 791
type: UnificationXref
id: P40977
db: uniprot

uniprot O70143 749
type: UnificationXref
id: O70143
db: uniprot

uniprot O18735 205
type: UnificationXref
id: O18735
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WV79 314
organism: Monodelphis domestica

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A3Q1M353 942
organism: Bos taurus

Protein CBR-LET-60
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot A8X0X5 627
organism: Caenorhabditis briggsae

uniprot O74304 721
type: UnificationXref
id: O74304
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot E2R428 1144
organism: Canis lupus familiaris

uniprot Q9UQC2 1069
type: UnificationXref
id: Q9UQC2
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot O08648 717
organism: Mus musculus

uniprot A9UJN4 393
type: UnificationXref
id: A9UJN4
db: uniprot

Protein sprouty homolog 4
type: DnaReference
xref: PTHR12365:SF6
organism: Bos taurus

uniprot Q9WUA6 616
type: UnificationXref
id: Q9WUA6
db: uniprot

uniprot Q9WTQ0 1218
type: UnificationXref
id: Q9WTQ0
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot F6Y9I6 1155
xref: PTHR22968:SF9
organism: Macaca mulatta

uniprot F1MAI3 881
type: UnificationXref
id: F1MAI3
db: uniprot

uniprot F1PS03 782
type: UnificationXref
id: F1PS03
db: uniprot

PTHR24072:SF287
type: RelationshipXref
id: PTHR24072:SF287
db: PANTHER Family
relationship type: By Homology

PTHR24072:SF289
type: RelationshipXref
id: PTHR24072:SF289
db: PANTHER Family
relationship type: By Homology

ERBB3 protein
type: ProteinReference
xref: PTHR24416:SF88
xref: uniprot A6QR62 197
organism: Bos taurus

uniprot P87253 1196
type: UnificationXref
id: P87253
db: uniprot

uniprot F4HRJ4 706
type: UnificationXref
id: F4HRJ4
db: uniprot

Serine/threonine-protein kinase D2
type: ProteinReference
xref: uniprot Q9BZL6 1217
xref: PTHR22968:SF12
organism: Homo sapiens

MKK4,7
type: ProteinReference
xref: P00555
standard name: Dual specificity mitogen-activated protein kinase kinase 4 and 7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Dual specificity mitogen-activated protein kinase kinase 4 and 7 Synonym: MAP kinase kinase 4 and 7,MAPK/ERK kinase 4 and 7,MAPKK 4 and 7 Accession: P00555
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.MKK4,7
member entity reference: Mitogen-activated protein kinase kinase 4A
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase 7
member entity reference: Dual specificity mitogen-activated protein kinase kinase hemipterous
member entity reference: Dual specificity mitogen-activated protein kinase kinase 7
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase 4
member entity reference: MAP kinase kinase 4, isoform A
member entity reference: MAP2K4 protein
member entity reference: MAP2K4 isoform 3

uniprot F5HEA9 232
type: UnificationXref
id: F5HEA9
db: uniprot

RAS protein activator like 2
type: ProteinReference
xref: uniprot F1NW82 347
xref: PTHR10194:SF52
organism: Gallus gallus

Phosphatidylethanolamine-binding protein 1
type: ProteinReference
xref: PTHR11362:SF10
xref: uniprot P70296 511
organism: Mus musculus

uniprot A0A2I3THL4 940
type: UnificationXref
id: A0A2I3THL4
db: uniprot

Phosphatidylethanolamine-binding protein 1
type: ProteinReference
xref: PTHR11362:SF82
xref: uniprot P13696 507
organism: Bos taurus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 1029
xref: PTHR24055:SF110
organism: Mus musculus

uniprot P47811 1029
type: UnificationXref
id: P47811
db: uniprot

uniprot P29310 74
type: UnificationXref
id: P29310
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
type: ProteinReference
xref: uniprot P40977 791
organism: Schizosaccharomyces pombe

uniprot Q29QL9 514
type: UnificationXref
id: Q29QL9
db: uniprot

14-3-3 family protein
type: ProteinReference
xref: uniprot F4I1B7 37
organism: Arabidopsis thaliana

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 939
evidence: Evidence 936
evidence: Evidence 937
evidence: Evidence 938
xref: uniprot A0A2I3THL4 940
xref: PTHR44329:SF22
organism: Pan troglodytes

uniprot P21359 358
type: UnificationXref
id: P21359
db: uniprot

uniprot Q9VD02 531
type: UnificationXref
id: Q9VD02
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 38

uniprot F1N1S8 405
type: UnificationXref
id: F1N1S8
db: uniprot

ncbitaxon 227321 120
type: UnificationXref
id: 227321
db: ncbitaxon

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot A0A3Q1NH21 591
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7GAP5 835
xref: PTHR10048:SF33
organism: Ornithorhynchus anatinus

Receptor protein-tyrosine kinase
type: ProteinReference
xref: PTHR24416:SF90
xref: uniprot F7G3H1 201
organism: Macaca mulatta

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 243
organism: Rattus norvegicus

uniprot E2R428 1144
type: UnificationXref
id: E2R428
db: uniprot

uniprot P40792 1099
type: UnificationXref
id: P40792
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P47809 772
xref: PTHR48013:SF15
organism: Mus musculus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A2VDZ0 382
xref: PTHR10257:SF6
organism: Bos taurus

uniprot F6RCU6 601
type: UnificationXref
id: F6RCU6
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
type: ProteinReference
xref: uniprot O00750 844
xref: PTHR10048:SF30
organism: Homo sapiens

14-3-3 protein homolog
type: ProteinReference
xref: uniprot O42766 68
xref: PTHR18860:SF17
organism: Candida albicans

GTPase-activating protein
type: ProteinReference
xref: PTHR10194:SF126
xref: uniprot P48423 359
organism: Drosophila melanogaster

uniprot F7EI48 236
type: UnificationXref
id: F7EI48
db: uniprot

EGFR
type: Protein
entity reference: EGFR
feature: EGFR s123 a4 rs4
feature: EGFR s123 a4 rs3
feature: EGFR s123 a4 rs1
feature: EGFR s123 a4 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q95115 1008
type: UnificationXref
id: Q95115
db: uniprot

uniprot A0A3Q1MNG1 151
type: UnificationXref
id: A0A3Q1MNG1
db: uniprot

uniprot Q9LU89 487
type: UnificationXref
id: Q9LU89
db: uniprot

uniprot F7EPN2 350
type: UnificationXref
id: F7EPN2
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O00329 842
organism: Homo sapiens

uniprot P39745 249
type: UnificationXref
id: P39745
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot E2QVP6 27
organism: Canis lupus familiaris

PTHR24070:SF251
type: RelationshipXref
id: PTHR24070:SF251
db: PANTHER Family
relationship type: By Homology

Danio rerio
type: BioSource
xref: ncbitaxon 7955 31

uniprot A8XTZ1 780
type: UnificationXref
id: A8XTZ1
db: uniprot

uniprot Q9D9G2 526
type: UnificationXref
id: Q9D9G2
db: uniprot

uniprot Q05144 1105
type: UnificationXref
id: Q05144
db: uniprot

uniprot Q62799 217
type: UnificationXref
id: Q62799
db: uniprot

Protein kinase C, eye isozyme
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P13677 1180
organism: Drosophila melanogaster

uniprot Q9C5C0 277
type: UnificationXref
id: Q9C5C0
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot Q63538 1037
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot F7AKA6 710
organism: Monodelphis domestica

Sprouty RTK-signaling antagonist 2
type: DnaReference
xref: PTHR12365:SF8
organism: Xenopus tropicalis

Mitogen-activated protein kinase kinase kinase 3 isoform 1
type: ProteinReference
xref: uniprot A0A1D5QJ66 696
xref: PTHR24361:SF656
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r18 1264
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 1.0

uniprot H2QAS6 1166
type: UnificationXref
id: H2QAS6
db: uniprot

uniprot A0A3Q1N9F5 1135
type: UnificationXref
id: A0A3Q1N9F5
db: uniprot

uniprot H2QN18 294
type: UnificationXref
id: H2QN18
db: uniprot

Raf-1
type: Protein
entity reference: Raf-1
feature: Raf 1 s24 a27 rs4
feature: ACTIVE 167
feature: Raf 1 s24 a27 rs2
feature: Raf 1 s24 a27 rs3
feature: Raf 1 s24 a27 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9XW37 535
type: UnificationXref
id: Q9XW37
db: uniprot

uniprot A2VDU1 169
type: UnificationXref
id: A2VDU1
db: uniprot

uniprot P31955 563
type: UnificationXref
id: P31955
db: uniprot

Receptor tyrosine-protein kinase erbB-2
type: ProteinReference
xref: PTHR24416:SF137
xref: uniprot P06494 209
organism: Rattus norvegicus

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 4

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot D4A5Q1 811
organism: Rattus norvegicus

uniprot Q3SZI4 118
type: UnificationXref
id: Q3SZI4
db: uniprot

uniprot A0A0R4IY09 589
type: UnificationXref
id: A0A0R4IY09
db: uniprot

MKK4,7 s48 a62 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Serine/threonine-protein kinase D1
type: ProteinReference
xref: uniprot Q15139 1204
xref: PTHR22968:SF9
organism: Homo sapiens

uniprot F7BXD0 645
type: UnificationXref
id: F7BXD0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot A0A0D1C4Y4 223
organism: Ustilago maydis

uniprot F1Q4C2 175
type: UnificationXref
id: F1Q4C2
db: uniprot

uniprot P01133 557
type: UnificationXref
id: P01133
db: uniprot

uniprot P62070 677
type: UnificationXref
id: P62070
db: uniprot

14-3-3-like protein GF14-C
type: ProteinReference
xref: uniprot Q6ZKC0 137
xref: PTHR18860:SF109
organism: Oryza sativa

MTK1/MEKK4 homolog
type: ProteinReference
xref: uniprot Q960A2 736
organism: Caenorhabditis elegans

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A2I3TRY9 802
organism: Pan troglodytes

uniprot E2RKA7 1015
type: UnificationXref
id: E2RKA7
db: uniprot

uniprot P42227 991
type: UnificationXref
id: P42227
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1N795 345
xref: PTHR10194:SF21
organism: Bos taurus

uniprot Q803G3 478
type: UnificationXref
id: Q803G3
db: uniprot

Protein enhancer of sevenless 2B
type: ProteinReference
xref: uniprot Q08012 582
xref: PTHR46037:SF1
organism: Drosophila melanogaster

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot P15056 957
organism: Homo sapiens

uniprot A0A1D5Q8S8 285
type: UnificationXref
id: A0A1D5Q8S8
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot Q4KSH7 774
xref: PTHR48013:SF17
organism: Rattus norvegicus

uniprot F7FK53 548
type: UnificationXref
id: F7FK53
db: uniprot

Mitogen-activated protein kinase 5
type: ProteinReference
xref: uniprot Q10N20 254
organism: Oryza sativa

Serine/threonine-protein kinase D2
type: ProteinReference
xref: uniprot Q8BZ03 1214
xref: PTHR22968:SF12
organism: Mus musculus

ACTIVE 167
type: EntityFeature
comment: Active state

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot P35213 81
organism: Rattus norvegicus

uniprot A0A1D5QKD3 905
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6XP81 602
organism: Xenopus tropicalis

uniprot Q64620 466
type: UnificationXref
id: Q64620
db: uniprot

uniprot P70424 212
type: UnificationXref
id: P70424
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot F6PXH5 155
xref: PTHR48013:SF21
organism: Ornithorhynchus anatinus

uniprot F1NW82 347
type: UnificationXref
id: F1NW82
db: uniprot

uniprot P11345 953
type: UnificationXref
id: P11345
db: uniprot

uniprot Q0DBD3 452
type: UnificationXref
id: Q0DBD3
db: uniprot

Protein sprouty homolog 4
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot A2VDU1 169
organism: Bos taurus

uniprot P62259 97
type: UnificationXref
id: P62259
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7G8G5 983
xref: PTHR11801:SF2
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FRT9 60
xref: PTHR18860:SF7
organism: Monodelphis domestica

Ras-like protein rasG
type: ProteinReference
xref: uniprot P15064 671
xref: PTHR24070:SF17
organism: Dictyostelium discoideum

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
type: ProteinReference
xref: PTHR10257:SF3
xref: uniprot Q10428 454
organism: Schizosaccharomyces pombe

uniprot Q3UHC7 364
type: UnificationXref
id: Q3UHC7
db: uniprot

uniprot F7G3H1 201
type: UnificationXref
id: F7G3H1
db: uniprot

Stress-activated protein kinase JNK
type: ProteinReference
xref: uniprot P92208 330
organism: Drosophila melanogaster

Neurofibromin
type: ProteinReference
xref: PTHR10194:SF60
xref: uniprot Q04690 362
organism: Mus musculus

uniprot Q66JE6 929
type: UnificationXref
id: Q66JE6
db: uniprot

uniprot D3Z8L7 630
type: UnificationXref
id: D3Z8L7
db: uniprot

GLH-binding kinase 1
type: ProteinReference
xref: uniprot O44408 323
organism: Caenorhabditis elegans

PTHR10048:SF64
type: RelationshipXref
id: PTHR10048:SF64
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZKJ2 131
xref: PTHR18860:SF16
organism: Gallus gallus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 82

uniprot A8X0R4 16
type: UnificationXref
id: A8X0R4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FRS1 648
organism: Monodelphis domestica

uniprot A8JGV6 13
type: UnificationXref
id: A8JGV6
db: uniprot

Serine/threonine-protein phosphatase PP2A-4 catalytic subunit
type: ProteinReference
xref: uniprot A3C4N5 383
organism: Oryza sativa

TRANSCRIPTION_LEFT__SPRY-RIGHT__SPRY-_re29
type: TemplateReaction
product: SPRY
xref: TRANSCRIPTION
participant: SPRY
comment: REACTION_REVERSIBLE=false
interaction type: TRANSCRIPTION

Serine/threonine-protein phosphatase PP2A
type: ProteinReference
xref: uniprot P23696 436
xref: PTHR45619:SF12
organism: Drosophila melanogaster

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot P08647 667
type: UnificationXref
id: P08647
db: uniprot

uniprot Q7TNL5 475
type: UnificationXref
id: Q7TNL5
db: uniprot

INHIBITION
type: RelationshipTypeVocabulary

uniprot H2R8U9 889
type: UnificationXref
id: H2R8U9
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot Q6YX33 471
organism: Oryza sativa

STATE_TRANSITION_LEFT__RKIP-RIGHT__RKIP-_r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 1278
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 1279
left: RKIP
interaction type: STATE_TRANSITION
right: RKIP

uniprot Q54R82 730
type: UnificationXref
id: Q54R82
db: uniprot

uniprot P22681 295
type: UnificationXref
id: P22681
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot E1BWA3 1142
organism: Gallus gallus

uniprot F1P7F6 1055
type: UnificationXref
id: F1P7F6
db: uniprot

Protein CBR-SEM-5
type: ProteinReference
xref: uniprot A8XPY6 580
xref: PTHR46037:SF1
organism: Caenorhabditis briggsae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK1_2-RIGHT__MEK1_2-_r9
controller: Raf-1

PTHR44305:SF4
type: RelationshipXref
id: PTHR44305:SF4
db: PANTHER Family
relationship type: By Homology

uniprot H2Q411 424
type: UnificationXref
id: H2Q411
db: uniprot

Serine/threonine-protein kinase D2
type: ProteinReference
xref: uniprot Q5XIS9 1208
xref: PTHR22968:SF12
organism: Rattus norvegicus

SHC-transforming protein homolog 1
type: ProteinReference
xref: uniprot Q9TYT3 759
xref: PTHR10337:SF11
organism: Caenorhabditis elegans

MAP kinase kinase kinase SSK2
type: ProteinReference
xref: uniprot P53599 725
organism: Saccharomyces cerevisiae

uniprot F7GQV4 179
type: UnificationXref
id: F7GQV4
db: uniprot

PARTICIPANT STOICHIOMETRY r18 1265
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

MKK4,7 s48 a62 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot A7EJF2 225
type: UnificationXref
id: A7EJF2
db: uniprot

uniprot A0A1D5R985 1131
type: UnificationXref
id: A0A1D5R985
db: uniprot

uniprot A0A1D5R9X3 965
type: UnificationXref
id: A0A1D5R9X3
db: uniprot

uniprot P20936 357
type: UnificationXref
id: P20936
db: uniprot

MAP kinase kinase kinase mkh1
type: ProteinReference
xref: uniprot Q10407 727
organism: Schizosaccharomyces pombe

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

uniprot F7GLY8 159
type: UnificationXref
id: F7GLY8
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
type: ProteinReference
xref: uniprot Q28DR3 116
xref: PTHR18860:SF16
organism: Xenopus tropicalis

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1MK31 340
xref: PTHR10194:SF4
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot F7HLC7 836
organism: Macaca mulatta

uniprot A0A3Q2TY19 308
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

uniprot Q01279 213
type: UnificationXref
id: Q01279
db: uniprot

Gab s12 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gab
stoichiometric coefficient: 1.0

LD28067p
type: ProteinReference
xref: uniprot Q7K3H0 869
xref: PTHR10048:SF64
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: uniprot Q86H88 520
organism: Dictyostelium discoideum

uniprot D3ZVF3 809
type: UnificationXref
id: D3ZVF3
db: uniprot

uniprot F1MY82 1151
type: UnificationXref
id: F1MY82
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
type: ProteinReference
xref: PTHR10257:SF4
xref: uniprot Q15173 459
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
type: ProteinReference
xref: uniprot Q15172 458
xref: PTHR10257:SF6
organism: Homo sapiens

uniprot F1A411 639
type: UnificationXref
id: F1A411
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot A0A2I3RQJ8 1132
organism: Pan troglodytes

uniprot A0A140T878 962
type: UnificationXref
id: A0A140T878
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A3Q1LQK4 805
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24351:SF200
xref: uniprot G3X7B5 604
organism: Bos taurus

Akt s21 a24 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P43322 565
type: UnificationXref
id: P43322
db: uniprot

PTHR10048:SF48
type: RelationshipXref
id: PTHR10048:SF48
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7CP86 418
xref: PTHR45619:SF44
organism: Monodelphis domestica

Protein sprouty homolog 2
type: ProteinReference
xref: PTHR12365:SF8
xref: uniprot Q9PTL2 190
organism: Gallus gallus

RCG49355
type: DnaReference
xref: PTHR12365:SF6
organism: Rattus norvegicus

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot Q75LC7 472
organism: Oryza sativa

PTHR48016:SF32
type: RelationshipXref
id: PTHR48016:SF32
db: PANTHER Family
relationship type: By Homology

uniprot Q8UUX0 615
type: UnificationXref
id: Q8UUX0
db: uniprot

uniprot A0A3Q1M353 942
type: UnificationXref
id: A0A3Q1M353
db: uniprot

uniprot D4A4I3 810
type: UnificationXref
id: D4A4I3
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 403

uniprot Q803F2 1122
type: UnificationXref
id: Q803F2
db: uniprot

uniprot F6S0N0 501
type: UnificationXref
id: F6S0N0
db: uniprot

Betacellulin
type: ProteinReference
xref: uniprot A2VE27 540
organism: Bos taurus

uniprot Q61084 733
type: UnificationXref
id: Q61084
db: uniprot

uniprot P53779 328
type: UnificationXref
id: P53779
db: uniprot

uniprot F7BYI4 1158
type: UnificationXref
id: F7BYI4
db: uniprot

uniprot O35569 556
type: UnificationXref
id: O35569
db: uniprot

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: uniprot Q503B6 686
xref: PTHR24070:SF423
organism: Danio rerio

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: PTHR48013:SF12
xref: uniprot E2R7W7 153
organism: Canis lupus familiaris

uniprot A0A0G2K3R1 695
type: UnificationXref
id: A0A0G2K3R1
db: uniprot

uniprot P31946 78
type: UnificationXref
id: P31946
db: uniprot

uniprot O42766 68
type: UnificationXref
id: O42766
db: uniprot

uniprot Q10407 727
type: UnificationXref
id: Q10407
db: uniprot

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

uniprot Q01389 726
type: UnificationXref
id: Q01389
db: uniprot

ncbitaxon 5786 403
type: UnificationXref
id: 5786
db: ncbitaxon

uniprot P23595 434
type: UnificationXref
id: P23595
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F7BS95 54
organism: Monodelphis domestica

uniprot Q6P943 1006
type: UnificationXref
id: Q6P943
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q7QEQ3 1007
organism: Anopheles gambiae

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot I0FRT6 715
xref: PTHR11584:SF332
organism: Macaca mulatta

ncbitaxon 8364 58
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot A0A0G2JTA1 374
type: UnificationXref
id: A0A0G2JTA1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CKV9 1087
organism: Monodelphis domestica

Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit
type: ProteinReference
xref: uniprot P23636 435
organism: Schizosaccharomyces pombe

STATE_TRANSITION_LEFT__MEK1_2-RIGHT__MEK1_2-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 1269
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 1268
left: MEK1-2
interaction type: STATE_TRANSITION
right: MEK1-2

uniprot P36583 1191
type: UnificationXref
id: P36583
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot J9P6N4 67
organism: Canis lupus familiaris

Rac family small GTPase 3b
type: ProteinReference
xref: uniprot A9JRY8 1073
xref: PTHR24072:SF301
organism: Danio rerio

Cbl proto-oncogene
type: ProteinReference
xref: PTHR23007:SF5
xref: uniprot A0A3Q1LN00 287
organism: Bos taurus

Rho-related protein racF1
type: ProteinReference
xref: uniprot O96390 1091
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MXH6 704
xref: PTHR11584:SF332
organism: Bos taurus

uniprot P31938 914
type: UnificationXref
id: P31938
db: uniprot

PTHR10048:SF29
type: RelationshipXref
id: PTHR10048:SF29
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF28
type: RelationshipXref
id: PTHR10048:SF28
db: PANTHER Family
relationship type: By Homology

PTHR23113:SF341
type: RelationshipXref
id: PTHR23113:SF341
db: PANTHER Family
relationship type: By Homology

uniprot F7HC75 1163
type: UnificationXref
id: F7HC75
db: uniprot

uniprot A0A2I3T7A8 801
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

uniprot F7C5Z9 417
type: UnificationXref
id: F7C5Z9
db: uniprot

PTHR10048:SF30
type: RelationshipXref
id: PTHR10048:SF30
db: PANTHER Family
relationship type: By Homology

Rac
type: ProteinReference
xref: P00564
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Rac
comment: ENTITY_REFERENCE_NOTES=Long Name: Rac Synonym: Synonym not specified Accession: P00564
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Uncharacterized protein
member entity reference: Ras-related protein Rac1
member entity reference: Rac family small GTPase 1a
member entity reference: Rac family small GTPase 3
member entity reference: Uncharacterized protein racC
member entity reference: Rac-like GTP-binding protein 7
member entity reference: GTPase cRac1A
member entity reference: Rop-family small GTPase
member entity reference: Rho-related protein racF2
member entity reference: Rho-related protein rac1A
member entity reference: Uncharacterized protein rac1A
member entity reference: Ras homolog family member J
member entity reference: Ras-related protein rac-2
member entity reference: Rho-related protein rac1C
member entity reference: Rho-related protein racC
member entity reference: Rac family small GTPase 3a
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Rho family GTPase
member entity reference: Rac-like GTP-binding protein 3
member entity reference: Rho-related protein rac1B
member entity reference: Rac1B, RHO family GTPase
member entity reference: Rac family small GTPase 1
member entity reference: Rac-like GTP-binding protein 5
member entity reference: Rac-like GTP-binding protein ARAC7
member entity reference: Rac-like GTP-binding protein 1
member entity reference: Rho-related protein racF1
member entity reference: Rac-like GTP-binding protein ARAC8
member entity reference: Rac-like GTP-binding protein ARAC9
member entity reference: Rac-like GTP-binding protein 6
member entity reference: Ras homolog family member Q
member entity reference: Rac-like GTP-binding protein ARAC10
member entity reference: Rho-related protein racB
member entity reference: Rac family small GTPase 1b
member entity reference: Rac-like GTP-binding protein ARAC2
member entity reference: Rac family small GTPase 3b
member entity reference: Ras homolog family member Gb
member entity reference: Ras-related protein Rac2
member entity reference: Ras homolog gene family, member Gc
member entity reference: Rac family small GTPase 2
member entity reference: Rho-related protein racA
member entity reference: Rho-related protein racG
member entity reference: Rac-like GTP-binding protein ARAC4
member entity reference: Ras-related protein ced-10

14-3-3 protein 2
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot C4LXB1 23
organism: Entamoeba histolytica

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot A0A1D5R8E9 777
organism: Macaca mulatta

ARTA
type: ProteinReference
xref: uniprot Q5B4M9 119
xref: PTHR18860:SF17
organism: Emericella nidulans

Protein CBR-PAR-5
type: ProteinReference
xref: uniprot A8X0R4 16
xref: PTHR18860:SF21
organism: Caenorhabditis briggsae

uniprot H2KZI0 320
type: UnificationXref
id: H2KZI0
db: uniprot

EGF
type: ProteinReference
xref: P00549
standard name: Epidermal growth factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Epidermal growth factor Synonym: gurken,transforming growth factor alpha Accession: P00549
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.EGF
member entity reference: Protransforming growth factor alpha
member entity reference: Betacellulin
member entity reference: Proepiregulin
member entity reference: Pro-neuregulin-2, membrane-bound isoform
member entity reference: Pro-epidermal growth factor
member entity reference: Uncharacterized protein
member entity reference: Amphiregulin
member entity reference: EREG isoform 1
member entity reference: Proheparin-binding EGF-like growth factor
member entity reference: Pro-neuregulin-1, membrane-bound isoform
member entity reference: Heparin binding EGF like growth factor
member entity reference: Transforming growth factor alpha
member entity reference: Neuregulin 3
member entity reference: Pro-neuregulin-4, membrane-bound isoform
member entity reference: HBEGF isoform 1
member entity reference: Probetacellulin
member entity reference: BTC isoform 1
member entity reference: Pro-neuregulin-3, membrane-bound isoform
member entity reference: Neuregulin 1

uniprot C4M5T0 1077
type: UnificationXref
id: C4M5T0
db: uniprot

uniprot Q4QQQ5 775
type: UnificationXref
id: Q4QQQ5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F7GLY8 159
organism: Macaca mulatta

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70167 847
organism: Mus musculus

uniprot P48423 359
type: UnificationXref
id: P48423
db: uniprot

uniprot O08648 717
type: UnificationXref
id: O08648
db: uniprot

Transcription cell cycle progression
type: Pathway

uniprot F6PKB8 410
type: UnificationXref
id: F6PKB8
db: uniprot

Grb2 s138 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot W4ZAK5 494
xref: PTHR45619:SF12
organism: Strongylocentrotus purpuratus

uniprot F1PV54 408
type: UnificationXref
id: F1PV54
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q63932 928
xref: PTHR48013:SF8
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q7RVR1 273
organism: Neurospora crassa

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F6TAH0 784
organism: Monodelphis domestica

uniprot Q29RC5 1106
type: UnificationXref
id: Q29RC5
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A0G2JZD1 375
xref: PTHR10257:SF19
organism: Rattus norvegicus

uniprot P42228 992
type: UnificationXref
id: P42228
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF26
xref: uniprot A0A1D5Q7W8 336
organism: Macaca mulatta

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70173 848
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6RCU6 601
organism: Macaca mulatta

PTHR24416:SF88
type: RelationshipXref
id: PTHR24416:SF88
db: PANTHER Family
relationship type: By Homology

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot P62260 98
xref: PTHR18860:SF17
organism: Rattus norvegicus

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot P62261 99
xref: PTHR18860:SF17
organism: Bos taurus

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q9S7U9 931
organism: Arabidopsis thaliana

uniprot A0A3S5ZPX3 906
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

uniprot Q5Z859 268
type: UnificationXref
id: Q5Z859
db: uniprot

uniprot F0ZWE6 638
type: UnificationXref
id: F0ZWE6
db: uniprot

Disabled homolog 2-interacting protein
type: ProteinReference
xref: uniprot Q6P730 366
xref: PTHR10194:SF26
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r64 1257
type: Stoichiometry
physical entity: Complex (Grb2/SOS)
stoichiometric coefficient: 1.0

uniprot A0A1D5QLW6 776
type: UnificationXref
id: A0A1D5QLW6
db: uniprot

uniprot P53349 724
type: UnificationXref
id: P53349
db: uniprot

PARTICIPANT STOICHIOMETRY r64 1258
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r64 1259
type: Stoichiometry
physical entity: Complex (EGFR/PLC_gamma/ STAT/PI3K/ SHC/Gab/ Grb2/SOS/ GAP)
stoichiometric coefficient: 1.0

uniprot Q08BT6 1203
type: UnificationXref
id: Q08BT6
db: uniprot

PARTICIPANT STOICHIOMETRY r64 1253
type: Stoichiometry
physical entity: PLCgamma
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: PTHR48013:SF17
xref: uniprot A0A2I3SB47 762
organism: Pan troglodytes

uniprot P08642 665
type: UnificationXref
id: P08642
db: uniprot

PARTICIPANT STOICHIOMETRY r64 1254
type: Stoichiometry
physical entity: SHC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 1255
type: Stoichiometry
physical entity: GAP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 1256
type: Stoichiometry
physical entity: Gab
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 1251
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r64 1252
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

uniprot P42336 852
type: UnificationXref
id: P42336
db: uniprot

uniprot O02812 1022
type: UnificationXref
id: O02812
db: uniprot

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot P62259 97
xref: PTHR18860:SF17
organism: Mus musculus

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF67
xref: uniprot P62258 96
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42336 852
organism: Homo sapiens

uniprot Q6ZKC0 137
type: UnificationXref
id: Q6ZKC0
db: uniprot

Ras-related protein rac-2
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot Q94124 1124
organism: Caenorhabditis elegans

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P42338 854
xref: PTHR10048:SF33
organism: Homo sapiens

a87_degraded
type: PhysicalEntity
cellular location: cytosol
comment: SPECIES_TYPE=DEGRADED

Phosphatidylinositol 3-kinase age-1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q94125 876
organism: Caenorhabditis elegans

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P42337 853
organism: Mus musculus

Mitogen-activated protein kinase pmk-1
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot Q17446 1035
organism: Caenorhabditis elegans

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot P42339 855
organism: Arabidopsis thaliana

Protein CBR-MEK-2
type: ProteinReference
xref: uniprot A8WWD7 907
xref: PTHR48013:SF19
organism: Caenorhabditis briggsae

Protein kinase C zeta type
type: ProteinReference
xref: uniprot Q02956 1199
xref: PTHR24356:SF170
organism: Mus musculus

Serine/threonine-protein phosphatase 6 catalytic subunit
type: ProteinReference
xref: uniprot Q64620 466
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot Q7S7P2 474
organism: Neurospora crassa

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot A0A3Q1N9F5 1135
xref: PTHR22968:SF9
organism: Bos taurus

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1P859 883
xref: PTHR23113:SF150
organism: Canis lupus familiaris

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q6PF93 868
organism: Mus musculus

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot Q64617 1211
organism: Rattus norvegicus

uniprot F1N7C3 882
type: UnificationXref
id: F1N7C3
db: uniprot

uniprot F7AKA6 710
type: UnificationXref
id: F7AKA6
db: uniprot

uniprot A0A3Q1LJZ7 1011
type: UnificationXref
id: A0A3Q1LJZ7
db: uniprot

uniprot E2R2N2 230
type: UnificationXref
id: E2R2N2
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q95ME4 694
xref: PTHR24070:SF189
organism: Monodelphis domestica

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P63318 1193
xref: PTHR24356:SF162
organism: Mus musculus

uniprot F5HM76 500
type: UnificationXref
id: F5HM76
db: uniprot

Complex (EGFR/Grb2/ SOS)
type: Complex
component stoichiometry: Grb2 s2 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s136 sa5 STOICHIOMETRY ID COMPLEX
component: SOS
component: Grb2
component: EGFR
feature: COMPLEX BINDING FEATURE s89 a112 1221
feature: COMPLEX BINDING FEATURE s89 a112 1223
feature: COMPLEX BINDING FEATURE s89 a112 1219
cellular location: cytosol

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P63319 1194
xref: PTHR24356:SF162
organism: Rattus norvegicus

uniprot Q09892 1032
type: UnificationXref
id: Q09892
db: uniprot

Sprouty RTK signaling antagonist 4
type: DnaReference
xref: PTHR12365:SF6
organism: Canis lupus familiaris

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot F6W7C8 828
organism: Macaca mulatta

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P63331 445
xref: PTHR45619:SF42
organism: Rattus norvegicus

Serine/threonine-protein kinase KDX1
type: ProteinReference
xref: uniprot P36005 248
organism: Saccharomyces cerevisiae

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: PTHR10257:SF3
xref: uniprot A9UJN4 393
organism: Caenorhabditis elegans

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P63330 444
xref: PTHR45619:SF42
organism: Mus musculus

uniprot Q5E9X2 164
type: UnificationXref
id: Q5E9X2
db: uniprot

PTHR24361:SF414
type: RelationshipXref
id: PTHR24361:SF414
db: PANTHER Family
relationship type: By Homology

GRB2-associated-binding protein 1
type: ProteinReference
xref: PTHR45960:SF5
xref: uniprot A0A0G2JZD5 1047
organism: Rattus norvegicus

uniprot P49186 326
type: UnificationXref
id: P49186
db: uniprot

uniprot F7DVL1 1159
type: UnificationXref
id: F7DVL1
db: uniprot

Cbl proto-oncogene
type: ProteinReference
xref: PTHR23007:SF5
xref: uniprot F1P861 291
organism: Canis lupus familiaris

uniprot A0A2I3SQ00 539
type: UnificationXref
id: A0A2I3SQ00
db: uniprot

uniprot A4QP33 385
type: UnificationXref
id: A4QP33
db: uniprot

uniprot Q7PX08 140
type: UnificationXref
id: Q7PX08
db: uniprot

TRANSLATION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot Q61831 331
organism: Mus musculus

Evidence 588
type: Evidence
evidence code: ISS
comment: Website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
controller: Ras

uniprot Q15303 214
type: UnificationXref
id: Q15303
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7D2D3 982
xref: PTHR11801:SF39
organism: Monodelphis domestica

uniprot P42645 86
type: UnificationXref
id: P42645
db: uniprot

uniprot Q9WVL2 1010
type: UnificationXref
id: Q9WVL2
db: uniprot

PARTICIPANT STOICHIOMETRY r19 1260
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Signal transducer and transcription activator
type: ProteinReference
xref: uniprot Q24151 1003
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r19 1261
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PTHR10194:SF126
type: RelationshipXref
id: PTHR10194:SF126
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r19 1262
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 1263
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription 4
type: ProteinReference
xref: PTHR11801:SF19
xref: uniprot Q14765 1001
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot D3ZDI7 400
xref: PTHR10257:SF6
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r11 1278
type: Stoichiometry
physical entity: RKIP
stoichiometric coefficient: 1.0

uniprot P01120 661
type: UnificationXref
id: P01120
db: uniprot

uniprot Q5VWQ8 365
type: UnificationXref
id: Q5VWQ8
db: uniprot

ncbitaxon 9544 41
type: UnificationXref
id: 9544
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r11 1279
type: Stoichiometry
physical entity: RKIP
stoichiometric coefficient: 1.0

uniprot Q9S7U9 931
type: UnificationXref
id: Q9S7U9
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot E1C5A3 401
xref: PTHR10257:SF6
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BBM1 830
xref: PTHR10048:SF30
organism: Monodelphis domestica

uniprot P23298 1184
type: UnificationXref
id: P23298
db: uniprot

Grb2
type: Protein
entity reference: Grb2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q9XT09 932
organism: Pan troglodytes

ERK1 2 s27 a30 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot F1Q3M8 820
type: UnificationXref
id: F1Q3M8
db: uniprot

uniprot F6VXG1 827
type: UnificationXref
id: F6VXG1
db: uniprot

uniprot Q9LM33 280
type: UnificationXref
id: Q9LM33
db: uniprot

uniprot Q61194 867
type: UnificationXref
id: Q61194
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
type: ProteinReference
xref: uniprot F6XW91 50
xref: PTHR18860:SF7
organism: Ornithorhynchus anatinus

AGAP011036-PA (Fragment)
type: ProteinReference
xref: uniprot A0NBA9 806
xref: PTHR10048:SF64
organism: Anopheles gambiae

Sprouty RTK-signaling antagonist 2
type: DnaReference
xref: PTHR12365:SF8
organism: Rattus norvegicus

ERK1 2 s27 a30 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot A0A3Q1LSJ2 698
xref: PTHR48016:SF32
organism: Bos taurus

uniprot Q503B6 686
type: UnificationXref
id: Q503B6
db: uniprot

uniprot Q5BJU0 688
type: UnificationXref
id: Q5BJU0
db: uniprot

Stratifin
type: ProteinReference
xref: uniprot F7BU66 55
xref: PTHR18860:SF14
organism: Ornithorhynchus anatinus

PTHR24416:SF90
type: RelationshipXref
id: PTHR24416:SF90
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y478 52
xref: PTHR18860:SF3
organism: Canis lupus familiaris

PTHR24416:SF91
type: RelationshipXref
id: PTHR24416:SF91
db: PANTHER Family
relationship type: By Homology

uniprot Q9JJM4 576
type: UnificationXref
id: Q9JJM4
db: uniprot

Neurofibromin 1
type: ProteinReference
xref: PTHR10194:SF60
xref: uniprot F1PIZ0 348
organism: Canis lupus familiaris

uniprot Q59XU5 687
type: UnificationXref
id: Q59XU5
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q9FXT7 279
organism: Chlamydomonas reinhardtii

SHC-transforming protein 3
type: ProteinReference
xref: uniprot O70143 749
xref: PTHR10337:SF4
organism: Rattus norvegicus

uniprot Q15283 363
type: UnificationXref
id: Q15283
db: uniprot

SHC-transforming protein 2
type: ProteinReference
xref: uniprot O70142 748
xref: PTHR10337:SF5
organism: Rattus norvegicus

Protein sprouty homolog 1
type: ProteinReference
xref: PTHR12365:SF10
xref: uniprot A5D992 170
organism: Bos taurus

uniprot P54185 510
type: UnificationXref
id: P54185
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot Q14738 457
organism: Homo sapiens

uniprot Q9JHG7 877
type: UnificationXref
id: Q9JHG7
db: uniprot

uniprot Q62956 218
type: UnificationXref
id: Q62956
db: uniprot

RAS-related 2
type: ProteinReference
xref: uniprot Q5BJU0 688
organism: Rattus norvegicus

uniprot F7B5I9 1086
type: UnificationXref
id: F7B5I9
db: uniprot

uniprot A0A3Q1LSJ2 698
type: UnificationXref
id: A0A3Q1LSJ2
db: uniprot

uniprot Q8BSM5 1064
type: UnificationXref
id: Q8BSM5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r19
controller: Complex (EGFR/Grb2/ SOS)

uniprot Q38919 1108
type: UnificationXref
id: Q38919
db: uniprot

MAP2K1 protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q0VD16 921
organism: Bos taurus

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot J9P5W6 911
xref: PTHR48013:SF5
organism: Canis lupus familiaris

uniprot Q95NE7 1039
type: UnificationXref
id: Q95NE7
db: uniprot

uniprot B3S653 394
type: UnificationXref
id: B3S653
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F6QUW1 885
xref: PTHR23113:SF168
organism: Monodelphis domestica

uniprot A9SKN8 392
type: UnificationXref
id: A9SKN8
db: uniprot

uniprot Q24324 924
type: UnificationXref
id: Q24324
db: uniprot

PTHR10194:SF132
type: RelationshipXref
id: PTHR10194:SF132
db: PANTHER Family
relationship type: By Homology

uniprot Q10R90 455
type: UnificationXref
id: Q10R90
db: uniprot

uniprot A5PKL2 624
type: UnificationXref
id: A5PKL2
db: uniprot

ncbitaxon 10116 82
type: UnificationXref
id: 10116
db: ncbitaxon

AGAP007643-PA
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot A0NBC2 9
organism: Anopheles gambiae

PTHR10194:SF138
type: RelationshipXref
id: PTHR10194:SF138
db: PANTHER Family
relationship type: By Homology

uniprot C4M5Q7 1076
type: UnificationXref
id: C4M5Q7
db: uniprot

PLCgamma
type: Protein
entity reference: PLCgamma
feature: ACTIVE 167
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q8W4J2 275
type: UnificationXref
id: Q8W4J2
db: uniprot

uniprot E1BMX0 631
type: UnificationXref
id: E1BMX0
db: uniprot

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9Y243 618
xref: PTHR24356:SF190
organism: Homo sapiens

uniprot B7Q5I4 19
type: UnificationXref
id: B7Q5I4
db: uniprot

uniprot F7F3S0 832
type: UnificationXref
id: F7F3S0
db: uniprot

MAP2K2 isoform 1
type: ProteinReference
xref: uniprot K7BYT0 912
xref: PTHR48013:SF8
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot Q02158 792
organism: Dictyostelium discoideum

uniprot P23696 436
type: UnificationXref
id: P23696
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot O93599 986
organism: Danio rerio

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q02156 1198
xref: PTHR24356:SF159
organism: Homo sapiens

Ras-like protein 2
type: ProteinReference
xref: uniprot P04388 663
organism: Drosophila melanogaster

Grb2
type: Protein
entity reference: Grb2
feature: ACTIVE 167
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa14 1242
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7FDA0 833
xref: PTHR10048:SF33
organism: Monodelphis domestica

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot P31938 914
organism: Mus musculus

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

uniprot P32871 851
type: UnificationXref
id: P32871
db: uniprot

Serine/threonine-protein kinase D3
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot Q8K1Y2 1215
organism: Mus musculus

Phosphatidylethanolamine binding protein 4
type: ProteinReference
xref: uniprot F6S0N0 501
organism: Macaca mulatta

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q7PMF0 870
xref: PTHR10048:SF7
organism: Anopheles gambiae

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P40763 987
organism: Homo sapiens

uniprot Q5ZIF0 927
type: UnificationXref
id: Q5ZIF0
db: uniprot

uniprot O70173 848
type: UnificationXref
id: O70173
db: uniprot

Rac-like GTP-binding protein ARAC9
type: ProteinReference
xref: uniprot Q9XGU0 1130
organism: Arabidopsis thaliana

14-3-3 protein 1
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot C4M323 26
organism: Entamoeba histolytica

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P24583 1185
xref: PTHR24356:SF390
organism: Saccharomyces cerevisiae

PLCgamma
type: ProteinReference
xref: P00556
standard name: phospholipase c gamma
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.PLC_sub__gamma
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: phospholipase c gamma Synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma,phosphoinositide phospholipase C Accession: P00556
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: Phosphoinositide phospholipase C (Fragment)
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 229
organism: Bos taurus

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot P31946 78
organism: Homo sapiens

14-3-3 protein sigma
type: ProteinReference
xref: uniprot P31947 79
xref: PTHR18860:SF14
organism: Homo sapiens

uniprot F1N7N8 346
type: UnificationXref
id: F1N7N8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45960:SF3
xref: uniprot A0A1D5RA78 1048
organism: Macaca mulatta

uniprot P63103 102
type: UnificationXref
id: P63103
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot K7CZM1 891
xref: PTHR23113:SF150
organism: Pan troglodytes

uniprot A0A3Q1MMD9 779
type: UnificationXref
id: A0A3Q1MMD9
db: uniprot

ncbitaxon 3218 390
type: UnificationXref
id: 3218
db: ncbitaxon

TRANSLATION
type: InteractionVocabulary

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 51

uniprot Q2QXL9 515
type: UnificationXref
id: Q2QXL9
db: uniprot

uniprot P63319 1194
type: UnificationXref
id: P63319
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q5SN53 267
organism: Oryza sativa

14-3-3 family protein 7
type: ProteinReference
xref: uniprot Q7RVK6 141
xref: PTHR18860:SF17
organism: Neurospora crassa

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: PTHR48013:SF12
xref: uniprot P70236 163
organism: Mus musculus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62715 442
xref: PTHR45619:SF44
organism: Mus musculus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62716 443
xref: PTHR45619:SF44
organism: Rattus norvegicus

uniprot D4A5Q1 811
type: UnificationXref
id: D4A5Q1
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62714 441
xref: PTHR45619:SF44
organism: Homo sapiens

uniprot Q07098 449
type: UnificationXref
id: Q07098
db: uniprot

uniprot F6YLW2 709
type: UnificationXref
id: F6YLW2
db: uniprot

uniprot E2R7W7 153
type: UnificationXref
id: E2R7W7
db: uniprot

uniprot G7MHX1 62
type: UnificationXref
id: G7MHX1
db: uniprot

STATE_TRANSITION_LEFT__p38-RIGHT__p38-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1292
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1293
left: p38
interaction type: STATE_TRANSITION
right: p38

uniprot F1P861 291
type: UnificationXref
id: F1P861
db: uniprot

uniprot P05771 1177
type: UnificationXref
id: P05771
db: uniprot

Rac-like GTP-binding protein 5
type: ProteinReference
xref: uniprot Q6EP31 1113
organism: Oryza sativa

uniprot C9J798 341
type: UnificationXref
id: C9J798
db: uniprot

uniprot E2REI6 944
type: UnificationXref
id: E2REI6
db: uniprot

PARTICIPANT STOICHIOMETRY r21 1249
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

uniprot F1PKW7 36
type: UnificationXref
id: F1PKW7
db: uniprot

PARTICIPANT STOICHIOMETRY r6 1277
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot Q7K3H0 869
type: UnificationXref
id: Q7K3H0
db: uniprot

PARTICIPANT STOICHIOMETRY r6 1276
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot A0A3Q1LPF2 697
type: UnificationXref
id: A0A3Q1LPF2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7E823 234
organism: Monodelphis domestica

MAP2K4 protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot A5PJP8 763
organism: Bos taurus

uniprot Q28GT8 461
type: UnificationXref
id: Q28GT8
db: uniprot

uniprot F7EY67 547
type: UnificationXref
id: F7EY67
db: uniprot

uniprot Q38903 1107
type: UnificationXref
id: Q38903
db: uniprot

B-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot A0A2I3TK00 941
organism: Pan troglodytes

Ras-related protein ced-10
type: ProteinReference
xref: uniprot Q03206 1104
xref: PTHR24072:SF281
organism: Caenorhabditis elegans

14-3-3 protein beta/alpha-A
type: ProteinReference
xref: uniprot Q5PRD0 127
xref: PTHR18860:SF28
organism: Danio rerio

uniprot A3C4N5 383
type: UnificationXref
id: A3C4N5
db: uniprot

uniprot A0A2I3TDL0 379
type: UnificationXref
id: A0A2I3TDL0
db: uniprot

uniprot P50520 857
type: UnificationXref
id: P50520
db: uniprot

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 28

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q08BT6 1203
organism: Xenopus tropicalis

Sprouty RTK signaling antagonist 3
type: DnaReference
organism: Bos taurus

uniprot E2RB82 969
type: UnificationXref
id: E2RB82
db: uniprot

GTPase cRac1A
type: ProteinReference
xref: uniprot Q6LC82 1115
xref: PTHR24072:SF105
organism: Gallus gallus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F1PNW8 974
xref: PTHR11801:SF39
organism: Canis lupus familiaris

uniprot P62716 443
type: UnificationXref
id: P62716
db: uniprot

Pro-neuregulin-3, membrane-bound isoform
type: ProteinReference
xref: uniprot P56975 568
organism: Homo sapiens

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot H2QUT2 65
organism: Pan troglodytes

uniprot F6PXH5 155
type: UnificationXref
id: F6PXH5
db: uniprot

Pro-neuregulin-2, membrane-bound isoform
type: ProteinReference
xref: uniprot P56974 567
organism: Mus musculus

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F1MAI3 881
organism: Rattus norvegicus

uniprot Q6PC29 136
type: UnificationXref
id: Q6PC29
db: uniprot

uniprot Q28DR3 116
type: UnificationXref
id: Q28DR3
db: uniprot

uniprot Q5U1Y2 1110
type: UnificationXref
id: Q5U1Y2
db: uniprot

CATALYSIS
type: Catalysis
controlled: KNOWN_TRANSITION_OMITTED_LEFT__MEKK1_5-RIGHT__MEKK1_5-_r22
controller: Rac

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q02111 1197
organism: Mus musculus

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s136 sa5 1224
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot J9P5W6 911
type: UnificationXref
id: J9P5W6
db: uniprot

PTHR10740:SF12
type: RelationshipXref
id: PTHR10740:SF12
db: PANTHER Family
relationship type: By Homology

uniprot P11346 955
type: UnificationXref
id: P11346
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7CHH2 980
xref: PTHR11801:SF47
organism: Monodelphis domestica

Receptor protein-tyrosine kinase (Fragment)
type: ProteinReference
xref: PTHR24416:SF566
xref: uniprot Q7PPN5 219
organism: Anopheles gambiae

uniprot F1MSX4 703
type: UnificationXref
id: F1MSX4
db: uniprot

Uncharacterized protein racC
type: ProteinReference
xref: uniprot F0ZN94 1081
xref: PTHR24072:SF310
organism: Dictyostelium purpureum

EGFR s129 a46 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.29874869898594847
comment: MODIFICATION_RESIDUE_NAME=

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EH19 235
xref: PTHR24055:SF203
organism: Xenopus tropicalis

uniprot A9SI18 391
type: UnificationXref
id: A9SI18
db: uniprot

uniprot A0A1D5QTL2 964
type: UnificationXref
id: A0A1D5QTL2
db: uniprot

uniprot P28482 247
type: UnificationXref
id: P28482
db: uniprot

uniprot P32491 916
type: UnificationXref
id: P32491
db: uniprot

uniprot P48348 88
type: UnificationXref
id: P48348
db: uniprot

Mitogen-activated protein kinase spm1
type: ProteinReference
xref: uniprot Q92398 276
organism: Schizosaccharomyces pombe

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6X958 415
xref: PTHR45619:SF44
organism: Canis lupus familiaris

Protein kinase C beta type
type: ProteinReference
xref: uniprot P68404 1195
xref: PTHR24356:SF158
organism: Mus musculus

Gab
type: Protein
entity reference: Gab
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa13 1240
feature: ACTIVE 167
feature: Gab s12 sa13 rs2
feature: Gab s12 sa13 rs3
feature: Gab s12 sa13 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot E9QAN8 816
type: UnificationXref
id: E9QAN8
db: uniprot

uniprot Q01525 110
type: UnificationXref
id: Q01525
db: uniprot

Akt
type: Protein
entity reference: Akt
feature: Akt s21 a24 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P15153 1092
type: UnificationXref
id: P15153
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__EGFR-RIGHT__EGFR-_r17
controller: EGF

uniprot F1PXD3 154
type: UnificationXref
id: F1PXD3
db: uniprot

uniprot F1NHL1 1152
type: UnificationXref
id: F1NHL1
db: uniprot

EGFR s129 a46 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.192356948147228

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A9SI18 391
organism: Physcomitrella patens

uniprot A0A3Q1LNS5 1051
type: UnificationXref
id: A0A3Q1LNS5
db: uniprot

uniprot P63331 445
type: UnificationXref
id: P63331
db: uniprot

uniprot K7CXU1 428
type: UnificationXref
id: K7CXU1
db: uniprot

EGFR
type: ProteinReference
xref: P00542
standard name: epidermal growth factor receptor
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.RECEPTOR.EGFR
comment: ENTITY_REFERENCE_NOTES=Long Name: EGFR Synonym: Gurken receptor, Erb, Neu, neuregulin Accession: P00542
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Epidermal growth factor receptor
member entity reference: Uncharacterized protein
member entity reference: ERBB3 protein
member entity reference: Receptor protein-tyrosine kinase
member entity reference: Receptor tyrosine-protein kinase erbB-2
member entity reference: Receptor tyrosine-protein kinase erbB-3
member entity reference: Receptor tyrosine-protein kinase erbB-4
member entity reference: Receptor protein-tyrosine kinase (Fragment)

Protein sprouty homolog 2
type: ProteinReference
xref: uniprot O43597 183
xref: PTHR12365:SF8
organism: Homo sapiens

uniprot O82480 1089
type: UnificationXref
id: O82480
db: uniprot

uniprot Q8RW96 483
type: UnificationXref
id: Q8RW96
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A0A3S5ZPJ0 381
organism: Gallus gallus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot P70618 1031
organism: Rattus norvegicus

Ras GTPase-activating protein 1
type: ProteinReference
xref: uniprot P20936 357
xref: PTHR10194:SF19
organism: Homo sapiens

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s138 sa1 1226
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1Q4F8 597
type: UnificationXref
id: F1Q4F8
db: uniprot

Protein CBR-RAS-2
type: ProteinReference
xref: uniprot A8XSS4 628
organism: Caenorhabditis briggsae

TRANSLATION_LEFT__SPRY-RIGHT__Spry-_re30
type: TemplateReaction
product: Spry
xref: TRANSLATION
participant: Spry
participant: SPRY
comment: REACTION_REVERSIBLE=false
interaction type: TRANSLATION

uniprot H2QHR7 1168
type: UnificationXref
id: H2QHR7
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F7DVL1 1159
organism: Xenopus tropicalis

Ras-related protein Rac1
type: ProteinReference
xref: uniprot P40792 1099
xref: PTHR24072:SF281
organism: Drosophila melanogaster

uniprot Q1K904 728
type: UnificationXref
id: Q1K904
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot H2QAS6 1166
organism: Pan troglodytes

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot Q5ANK2 1206
organism: Candida albicans

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot Q9JHG7 877
organism: Mus musculus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q0P594 453
xref: PTHR45619:SF44
organism: Bos taurus

Amphiregulin
type: ProteinReference
xref: uniprot P31955 563
xref: PTHR10740:SF12
organism: Mus musculus

uniprot Q9ASJ1 525
type: UnificationXref
id: Q9ASJ1
db: uniprot

uniprot A0A3Q1MM63 380
type: UnificationXref
id: A0A3Q1MM63
db: uniprot

EGFR s129 a46 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.271642349477033
comment: MODIFICATION_RESIDUE_NAME=

Protein TWIN SISTER of FT
type: ProteinReference
xref: uniprot Q9S7R5 528
organism: Arabidopsis thaliana

PP2A
type: Protein
entity reference: PP2A
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein kinase smg-1
type: ProteinReference
xref: uniprot O01510 845
organism: Caenorhabditis elegans

uniprot P21708 243
type: UnificationXref
id: P21708
db: uniprot

uniprot P67774 446
type: UnificationXref
id: P67774
db: uniprot

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P47196 609
organism: Rattus norvegicus

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47197 610
xref: PTHR24356:SF176
organism: Rattus norvegicus

GAP
type: Protein
entity reference: GAP
feature: ACTIVE 167
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P09217 1179
type: UnificationXref
id: P09217
db: uniprot

uniprot E9PYG6 343
type: UnificationXref
id: E9PYG6
db: uniprot

uniprot A0A0G2JZD1 375
type: UnificationXref
id: A0A0G2JZD1
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q9TXI7 878
xref: PTHR10048:SF7
organism: Caenorhabditis elegans

uniprot Q96TL5 1040
type: UnificationXref
id: Q96TL5
db: uniprot

uniprot F1RB17 821
type: UnificationXref
id: F1RB17
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38-RIGHT__p38-_r26
controller: MKK3,6

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05771 1177
xref: PTHR24356:SF158
organism: Homo sapiens

uniprot P48736 856
type: UnificationXref
id: P48736
db: uniprot

uniprot Q8BTI9 873
type: UnificationXref
id: Q8BTI9
db: uniprot

uniprot F6ZSZ9 200
type: UnificationXref
id: F6ZSZ9
db: uniprot

uniprot Q5PRD0 127
type: UnificationXref
id: Q5PRD0
db: uniprot

uniprot C3XQF4 397
type: UnificationXref
id: C3XQF4
db: uniprot

Pro-epidermal growth factor
type: ProteinReference
xref: uniprot P07522 560
organism: Rattus norvegicus

EGFR s129 a46 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.8660799645249737

uniprot B5DFH3 171
type: UnificationXref
id: B5DFH3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10740:SF4
xref: uniprot E1BIN8 541
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot A0A1D5R985 1131
organism: Macaca mulatta

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: PTHR10257:SF3
xref: uniprot A8Y4R8 388
organism: Caenorhabditis briggsae

uniprot O14733 769
type: UnificationXref
id: O14733
db: uniprot

Phosphatidylethanolamine-binding protein 4
type: ProteinReference
xref: uniprot Q9D9G2 526
organism: Mus musculus

uniprot Q7S7P2 474
type: UnificationXref
id: Q7S7P2
db: uniprot

Evidence 937
type: Evidence
evidence code: ISS
comment: SPACC P05625

Evidence 936
type: Evidence
evidence code: ISS
comment: SPACC P04049

Evidence 939
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

Evidence 938
type: Evidence
evidence code: ISS
comment: SPACC P11345

Protein kinase C
type: ProteinReference
xref: uniprot E2RNP2 1146
xref: PTHR24356:SF181
organism: Canis lupus familiaris

Protein sprouty homolog 1
type: ProteinReference
xref: PTHR12365:SF10
xref: uniprot F7GQV4 179
organism: Macaca mulatta

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

uniprot Q6PD03 469
type: UnificationXref
id: Q6PD03
db: uniprot

uniprot Q9VXB7 491
type: UnificationXref
id: Q9VXB7
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot A0A3Q1LJZ7 1011
organism: Bos taurus

uniprot H2Q383 839
type: UnificationXref
id: H2Q383
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__SOS-_Grb2-RIGHT__Complex__Grb2_SOS_-_r57
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1289
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1291
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 1290
left: Grb2
left: SOS
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Grb2/SOS)

Mitogen-activated protein kinase pmk-2
type: ProteinReference
xref: uniprot Q8MXI4 1038
xref: PTHR24055:SF154
organism: Caenorhabditis elegans

Muscle RAS oncogene homolog
type: ProteinReference
xref: uniprot E2QWU5 632
organism: Canis lupus familiaris

E3 ubiquitin-protein ligase CBL-B
type: ProteinReference
xref: PTHR23007:SF3
xref: uniprot Q3TTA7 299
organism: Mus musculus

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 10

uniprot P26675 892
type: UnificationXref
id: P26675
db: uniprot

Sprouty RTK signaling antagonist 4
type: DnaReference
xref: PTHR12365:SF6
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F3S0 832
xref: PTHR10048:SF33
organism: Macaca mulatta

uniprot F7F5X1 647
type: UnificationXref
id: F7F5X1
db: uniprot

Epidermal growth factor receptor
type: ProteinReference
xref: PTHR24416:SF566
xref: uniprot P04412 207
organism: Drosophila melanogaster

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F6Z5N3 643
organism: Monodelphis domestica

uniprot E1B8P9 229
type: UnificationXref
id: E1B8P9
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot Q62925 734
organism: Rattus norvegicus

uniprot E1BWA3 1142
type: UnificationXref
id: E1BWA3
db: uniprot

14-3-3-like protein GF14 lambda
type: ProteinReference
xref: uniprot P48349 90
xref: PTHR18860:SF69
organism: Arabidopsis thaliana

14-3-3-like protein GF14 kappa
type: ProteinReference
xref: PTHR18860:SF112
xref: uniprot P48348 88
organism: Arabidopsis thaliana

14-3-3-like protein GF14 epsilon
type: ProteinReference
xref: PTHR18860:SF72
xref: uniprot P48347 87
organism: Arabidopsis thaliana

GRB2 associated binding protein 1
type: ProteinReference
xref: PTHR45960:SF5
xref: uniprot F1P7F6 1055
organism: Canis lupus familiaris

uniprot Q5A1D3 266
type: UnificationXref
id: Q5A1D3
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot A0A1D5QKD3 905
organism: Macaca mulatta

uniprot Q6P023 270
type: UnificationXref
id: Q6P023
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot E2RSB0 1016
organism: Canis lupus familiaris

RAS p21 protein activator 2
type: ProteinReference
xref: PTHR10194:SF21
xref: uniprot H2QNH9 353
organism: Pan troglodytes

RKIP
type: Protein
entity reference: RKIP
feature: ACTIVE 167
feature: RKIP s29 a32 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P04388 663
type: UnificationXref
id: P04388
db: uniprot

uniprot P24723 1186
type: UnificationXref
id: P24723
db: uniprot

STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 1271
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 1270
left: Raf-1
interaction type: STATE_TRANSITION
right: Raf-1

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot P48736 856
organism: Homo sapiens

uniprot P14681 241
type: UnificationXref
id: P14681
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q1KQ07 1002
xref: PTHR11801:SF48
organism: Rattus norvegicus

uniprot G2HI54 61
type: UnificationXref
id: G2HI54
db: uniprot

PI3K
type: ProteinReference
xref: P00557
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_NOTES=Long Name: phosphatidylinositol 3-kinase Synonym: 5-bisphosphate 3-kinase,Phosphatidylinositol-4 Accession: P00557
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.PI3K
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 3-kinase 1
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: Phosphatidylinositol 3-kinase age-1
member entity reference: Phosphoinositide-3-kinase, regulatory subunit 5
member entity reference: Phosphatidylinositol 3-kinase, putative
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Uncharacterized protein
member entity reference: AGAP000018-PA
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: Phosphoinositide 3-kinase regulatory subunit 6
member entity reference: Phosphoinositide-3-kinase regulatory subunit 5
member entity reference: PIK3CG isoform 1
member entity reference: Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
member entity reference: Phosphoinositide-3-kinase, regulatory subunit 6
member entity reference: Phosphatidylinositol 3-kinase piki-1
member entity reference: PIK3C2A isoform 5
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
member entity reference: Phosphatidylinositol 3-kinase VPS34
member entity reference: Phosphatidylinositol 3-kinase vps34
member entity reference: LD28067p
member entity reference: Phosphoinositide 3-kinase regulatory subunit 5
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: PI-3 kinase
member entity reference: Phosphatidylinositol 3-kinase 3
member entity reference: Phosphatidylinositol 3-kinase VPS34-like
member entity reference: Phosphatidylinositol 3-kinase 2
member entity reference: PIK3R5 isoform 2
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot H2PXY8 838
organism: Pan troglodytes

Gab s64 a85 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot Q92398 276
type: UnificationXref
id: Q92398
db: uniprot

uniprot G3V6K6 203
type: UnificationXref
id: G3V6K6
db: uniprot

uniprot V5ILP2 743
type: UnificationXref
id: V5ILP2
db: uniprot

E3 ubiquitin-protein ligase CBL
type: ProteinReference
xref: uniprot P22681 295
xref: PTHR23007:SF5
organism: Homo sapiens

E3 ubiquitin-protein ligase CBL
type: ProteinReference
xref: PTHR23007:SF5
xref: uniprot P22682 296
organism: Mus musculus

Protein TERMINAL FLOWER 1
type: ProteinReference
xref: uniprot P93003 512
organism: Arabidopsis thaliana

uniprot P13677 1180
type: UnificationXref
id: P13677
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot O22042 719
organism: Arabidopsis thaliana

Akt s22 a25 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MODIFICATION FEATURE ubiquitinated
type: SequenceModificationVocabulary
comment: DATA_SOURCE=CellDesigner

uniprot Q4QHG6 263
type: UnificationXref
id: Q4QHG6
db: uniprot

14-3-3-like protein GF14 omega
type: ProteinReference
xref: uniprot Q01525 110
xref: PTHR18860:SF83
organism: Arabidopsis thaliana

uniprot Q20655 115
type: UnificationXref
id: Q20655
db: uniprot

uniprot Q9Y243 618
type: UnificationXref
id: Q9Y243
db: uniprot

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 895

MEKK1 5 s38 a40 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot P22682 296
type: UnificationXref
id: P22682
db: uniprot

uniprot Q9Z1S8 1071
type: UnificationXref
id: Q9Z1S8
db: uniprot

Protein sprouty
type: ProteinReference
xref: PTHR12365:SF7
xref: uniprot O44783 186
organism: Drosophila melanogaster

uniprot K7D3K8 985
type: UnificationXref
id: K7D3K8
db: uniprot

uniprot Q7QEJ7 871
type: UnificationXref
id: Q7QEJ7
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot F1MAA3 404
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P16054 1181
organism: Mus musculus

uniprot P29311 76
type: UnificationXref
id: P29311
db: uniprot

uniprot K7CZM1 891
type: UnificationXref
id: K7CZM1
db: uniprot

Raf 1 s24 a27 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.5815230303900968
comment: MODIFICATION_RESIDUE_NAME=

Evidence 961
type: Evidence
evidence code: IGI
comment: SPACC Q99N57

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot H9FYU7 890
organism: Macaca mulatta

uniprot Q9EQH1 1067
type: UnificationXref
id: Q9EQH1
db: uniprot

uniprot O00329 842
type: UnificationXref
id: O00329
db: uniprot

PTHR23007:SF12
type: RelationshipXref
id: PTHR23007:SF12
db: PANTHER Family
relationship type: By Homology

uniprot Q9S7R5 528
type: UnificationXref
id: Q9S7R5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1B8XW21 1072
organism: Xenopus tropicalis

uniprot A0A2I3SR38 1133
type: UnificationXref
id: A0A2I3SR38
db: uniprot

uniprot Q9DGE1 1041
type: UnificationXref
id: Q9DGE1
db: uniprot

uniprot A8WRD7 1013
type: UnificationXref
id: A8WRD7
db: uniprot

Evidence 949
type: Evidence
evidence code: IGI
comment: SPACC P04049

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
control type: INHIBITION
controller: RKIP

SOS
type: ProteinReference
xref: P00558
standard name: Son of sevenless
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: SOS Synonym: Synonym not specified Accession: P00558
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.SOS
member entity reference: Uncharacterized protein
member entity reference: Ras guanine nucleotide exchange factor E
member entity reference: Son of sevenless homolog 1
member entity reference: Son of sevenless homolog 2
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: Ras guanine nucleotide exchange factor B
member entity reference: Protein son of sevenless
member entity reference: Ras guanine nucleotide exchange factor A
member entity reference: Ras guanine nucleotide exchange factor P
member entity reference: Cell division control protein 25
member entity reference: Ras guanine nucleotide exchange factor Y
member entity reference: Ras guanine nucleotide exchange factor K

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK3,6-RIGHT__MKK3,6-_r25
controller: MEKK1-5

uniprot Q7KQK7 272
type: UnificationXref
id: Q7KQK7
db: uniprot

uniprot F1MIH6 174
type: UnificationXref
id: F1MIH6
db: uniprot

uniprot Q9QYY0 1068
type: UnificationXref
id: Q9QYY0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7EJF2 225
organism: Sclerotinia sclerotiorum

Ras guanine nucleotide exchange factor P
type: ProteinReference
xref: uniprot Q54TK8 899
organism: Dictyostelium discoideum

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot E9QAN8 816
organism: Mus musculus

MEKK1 5 s38 a40 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ERK1-2
type: ProteinReference
xref: P00543
standard name: Extracellular signal-regulated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Extracellular signal-regulated kinase Synonym: MAPK,Mitogen-activated protein kinase,pp42/44 Accession: P00543
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.ERK1_minus_2
member entity reference: Extracellular signal-regulated kinase 2
member entity reference: Mitogen-activated protein kinase spm1
member entity reference: Mitogen-activated protein kinase 20
member entity reference: Mitogen-activated protein kinase
member entity reference: Sporulation-specific mitogen-activated protein kinase SMK1
member entity reference: Mitogen-activated protein kinase SLT2/MPK1
member entity reference: Mitogen-activated protein kinase 18
member entity reference: Mitogen-activated protein kinase 19
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase mpk-1
member entity reference: Mitogen-activated protein kinase 5
member entity reference: Mitogen-activated protein kinase FUS3
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase 16
member entity reference: Mitogen-activated protein kinase 4
member entity reference: Putative mitogen-activated protein kinase
member entity reference: Serine/threonine-protein kinase KDX1
member entity reference: Mitogen-activated protein kinase KSS1
member entity reference: Mitogen-activated protein kinase 2
member entity reference: Mitogen-activated protein kinase spk1
member entity reference: Mitogen-activated protein kinase 15
member entity reference: Extracellular signal-regulated kinase 1

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot H2R8L2 747
type: UnificationXref
id: H2R8L2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1PMN2 312
xref: PTHR24055:SF162
organism: Canis lupus familiaris

uniprot I0FRT6 715
type: UnificationXref
id: I0FRT6
db: uniprot

uniprot P32490 915
type: UnificationXref
id: P32490
db: uniprot

PTHR10337:SF4
type: RelationshipXref
id: PTHR10337:SF4
db: PANTHER Family
relationship type: By Homology

uniprot O35904 846
type: UnificationXref
id: O35904
db: uniprot

PTHR10337:SF2
type: RelationshipXref
id: PTHR10337:SF2
db: PANTHER Family
relationship type: By Homology

uniprot P31044 509
type: UnificationXref
id: P31044
db: uniprot

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot F1M9D0 702
xref: PTHR24361:SF342
organism: Rattus norvegicus

PI3K s9 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

Evidence 954
type: Evidence
evidence code: IGI
comment: SPACC P11345

PTHR10337:SF5
type: RelationshipXref
id: PTHR10337:SF5
db: PANTHER Family
relationship type: By Homology

ncbitaxon 9615 28
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot A0A3Q2U980 621
type: UnificationXref
id: A0A3Q2U980
db: uniprot

uniprot P55245 211
type: UnificationXref
id: P55245
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7FHD1 237
xref: PTHR24055:SF203
organism: Monodelphis domestica

uniprot Q7QCN5 367
type: UnificationXref
id: Q7QCN5
db: uniprot

uniprot H2QUT2 65
type: UnificationXref
id: H2QUT2
db: uniprot

uniprot F7EH19 235
type: UnificationXref
id: F7EH19
db: uniprot

Protein sprouty homolog 2
type: DnaReference
xref: PTHR12365:SF8
organism: Bos taurus

uniprot F6Y4G8 315
type: UnificationXref
id: F6Y4G8
db: uniprot

uniprot Q7RVK6 141
type: UnificationXref
id: Q7RVK6
db: uniprot

uniprot A0A2J8MKA4 7
type: UnificationXref
id: A0A2J8MKA4
db: uniprot

uniprot P03967 662
type: UnificationXref
id: P03967
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: uniprot O00443 843
xref: PTHR10048:SF28
organism: Homo sapiens

MKK3,6
type: Protein
entity reference: MKK3,6
feature: ACTIVE 167
feature: MKK3,6 s52 a65 rs2
feature: MKK3,6 s52 a65 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r21 1250
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot Q4QQQ5 775
organism: Xenopus tropicalis

uniprot P63104 103
type: UnificationXref
id: P63104
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot F6TPY3 411
organism: Xenopus tropicalis

uniprot O35099 720
type: UnificationXref
id: O35099
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RKA7 1015
xref: PTHR24055:SF107
organism: Canis lupus familiaris

RAS p21 protein activator (GTPase activating protein) 1
type: ProteinReference
xref: uniprot H2QR74 354
xref: PTHR10194:SF19
organism: Pan troglodytes

Amphiregulin
type: ProteinReference
xref: uniprot P15514 561
xref: PTHR10740:SF12
organism: Homo sapiens

uniprot F7B5L8 317
type: UnificationXref
id: F7B5L8
db: uniprot

uniprot P05126 1173
type: UnificationXref
id: P05126
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q387R2 256
organism: Trypanosoma brucei

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot F5HEA9 232
organism: Phaeosphaeria nodorum

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot Q99683 737
xref: PTHR11584:SF332
organism: Homo sapiens

uniprot B7QGY5 396
type: UnificationXref
id: B7QGY5
db: uniprot

MEK1-2
type: ProteinReference
xref: P00559
standard name: Mitogen-activated protein kinase kinase 1 and 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: MAP/ERK kinase Synonym: Dual specificity mitogen-activated protein kinase kinase Accession: P00559
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.MEK1_minus_2
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: MAP2K2 isoform 1
member entity reference: Mitogen-activated protein kinase kinase 2
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase dSOR1
member entity reference: MAP kinase kinase MKK1/SSP32
member entity reference: Mitogen activated protein kinase kinase 2
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Mitogen-activated protein kinase kinase 6
member entity reference: Uncharacterized protein
member entity reference: Protein CBR-MEK-2
member entity reference: MAP kinase kinase MKK2/SSP33
member entity reference: Protein kinase byr1
member entity reference: MAP kinase kinase skh1/pek1
member entity reference: Dual specificity mitogen-activated protein kinase kinase mek-2
member entity reference: MAP2K1 protein

uniprot Q5ZKJ2 131
type: UnificationXref
id: Q5ZKJ2
db: uniprot

uniprot P68250 104
type: UnificationXref
id: P68250
db: uniprot

PI-3 kinase
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot P91634 862
organism: Drosophila melanogaster

uniprot Q7PRZ7 165
type: UnificationXref
id: Q7PRZ7
db: uniprot

uniprot Q61083 732
type: UnificationXref
id: Q61083
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XSJ9 1085
xref: PTHR24072:SF136
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r25 1297
type: Stoichiometry
physical entity: MKK3,6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r25 1296
type: Stoichiometry
physical entity: MKK3,6
stoichiometric coefficient: 1.0

uniprot F6T2X3 976
type: UnificationXref
id: F6T2X3
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 961
xref: uniprot Q99N57 960
xref: PTHR44329:SF22
organism: Mus musculus

uniprot O01510 845
type: UnificationXref
id: O01510
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 73

uniprot Q2R2W2 117
type: UnificationXref
id: Q2R2W2
db: uniprot

uniprot Q6EP31 1113
type: UnificationXref
id: Q6EP31
db: uniprot

R-Ras3
type: ProteinReference
xref: uniprot Q6JHX4 691
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r8 1270
type: Stoichiometry
physical entity: Raf-1
stoichiometric coefficient: 1.0

MKK3,6 s52 a65 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

PARTICIPANT STOICHIOMETRY r8 1271
type: Stoichiometry
physical entity: Raf-1
stoichiometric coefficient: 1.0

Ras-related protein M-Ras
type: ProteinReference
xref: uniprot F7BXD0 645
organism: Macaca mulatta

uniprot P17252 1182
type: UnificationXref
id: P17252
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A7F871 625
organism: Sclerotinia sclerotiorum

uniprot A0A1D5QQ23 194
type: UnificationXref
id: A0A1D5QQ23
db: uniprot

uniprot Q01986 919
type: UnificationXref
id: Q01986
db: uniprot

Phosphatidylethanolamine-binding protein 1
type: ProteinReference
xref: uniprot F6Y4G1 502
organism: Xenopus tropicalis

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
control type: INHIBITION
controller: 14-3-3

uniprot Q9SU67 1128
type: UnificationXref
id: Q9SU67
db: uniprot

Protein sprouty homolog 1
type: DnaReference
xref: PTHR12365:SF10
organism: Homo sapiens

RCG41526, isoform CRA_a
type: ProteinReference
xref: PTHR12365:SF10
xref: uniprot B5DFH3 171
organism: Rattus norvegicus

Gab s64 a85 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.591660794133728

14-3-3-like protein GF14-G
type: ProteinReference
xref: uniprot Q5QNB8 128
xref: PTHR18860:SF17
organism: Oryza sativa

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6Y4G8 315
organism: Canis lupus familiaris

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q1HG70 923
xref: PTHR48013:SF8
organism: Canis lupus familiaris

MAP3K5 isoform 1
type: ProteinReference
xref: uniprot K7CFQ9 716
xref: PTHR11584:SF332
organism: Pan troglodytes

uniprot P42232 995
type: UnificationXref
id: P42232
db: uniprot

MKK3,6 s52 a65 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot P38903 438
type: UnificationXref
id: P38903
db: uniprot

Protein sprouty homolog 2
type: DnaReference
xref: PTHR12365:SF8
organism: Homo sapiens

Protein sprouty homolog 3
type: DnaReference
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F1N1S8 405
xref: PTHR10257:SF89
organism: Bos taurus

uniprot A0A2I3SHP7 778
type: UnificationXref
id: A0A2I3SHP7
db: uniprot

uniprot F7DNM3 349
type: UnificationXref
id: F7DNM3
db: uniprot

Complex (EGFR/PLC_gamma/ STAT/PI3K/ SHC/Gab/ Grb2/SOS/ GAP)
type: Complex
component stoichiometry: Grb2 s13 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: SHC s11 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: STAT s8 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: PI3K s9 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gab s12 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: PLCgamma s6 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: GAP s15 sa16 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s14 sa15 STOICHIOMETRY ID COMPLEX
component: STAT
component: GAP
component: PI3K
component: PLCgamma
component: SHC
component: SOS
component: Grb2
component: Gab
component: EGFR
feature: COMPLEX BINDING FEATURE s122 a160 1229
feature: COMPLEX BINDING FEATURE s122 a160 1237
feature: COMPLEX BINDING FEATURE s122 a160 1235
feature: COMPLEX BINDING FEATURE s122 a160 1233
feature: COMPLEX BINDING FEATURE s122 a160 1243
feature: COMPLEX BINDING FEATURE s122 a160 1231
feature: COMPLEX BINDING FEATURE s122 a160 1239
feature: COMPLEX BINDING FEATURE s122 a160 1245
feature: COMPLEX BINDING FEATURE s122 a160 1241
cellular location: cytosol

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot P08642 665
organism: Gallus gallus

uniprot Q9VZZ9 1070
type: UnificationXref
id: Q9VZZ9
db: uniprot

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

uniprot P48554 1100
type: UnificationXref
id: P48554
db: uniprot

uniprot A0A2J8MGP0 803
type: UnificationXref
id: A0A2J8MGP0
db: uniprot

Gab s64 a85 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform
type: ProteinReference
xref: uniprot Q9ZQY6 493
organism: Arabidopsis thaliana

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
type: ProteinReference
xref: uniprot Q07098 449
organism: Arabidopsis thaliana

uniprot Q17446 1035
type: UnificationXref
id: Q17446
db: uniprot

Ras-like protein 1
type: ProteinReference
xref: uniprot P08647 667
organism: Schizosaccharomyces pombe

uniprot A0A2J8J4U3 1050
type: UnificationXref
id: A0A2J8J4U3
db: uniprot

Ras-like protein 1
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P08646 666
organism: Drosophila melanogaster

Pleckstrin homology-like domain family B member 2
type: ProteinReference
xref: uniprot Q8K1N2 1065
organism: Mus musculus

SHC
type: Protein
entity reference: SHC
feature: SHC s56 a73 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9FZ36 739
type: UnificationXref
id: Q9FZ36
db: uniprot

uniprot Q6Z437 271
type: UnificationXref
id: Q6Z437
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__STAT-_PI3K-_PLCgamma-_SHC-_GAP-_Gab-_Complex__Grb2_SOS_-_EGFR-RIGHT__Complex__EGFR_PLC_gamma__STAT_PI3K__SHC_Gab__Grb2_SOS__GAP_-_r64
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1253
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1252
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1251
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1259
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1254
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1255
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1258
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1257
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 1256
left: Complex (Grb2/SOS)
left: PI3K
left: PLCgamma
left: Gab
left: EGFR
left: STAT
left: SHC
left: GAP
interaction type: HETERODIMER_ASSOCIATION
right: Complex (EGFR/PLC_gamma/ STAT/PI3K/ SHC/Gab/ Grb2/SOS/ GAP)

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

SHC-transforming protein 2
type: ProteinReference
xref: uniprot Q8BMC3 757
xref: PTHR10337:SF5
organism: Mus musculus

EGFR s1 sa3 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.192356948147228

uniprot A0A2I3RYF9 196
type: UnificationXref
id: A0A2I3RYF9
db: uniprot

GAB2 isoform 1
type: ProteinReference
xref: uniprot H2R3E1 1060
xref: PTHR45960:SF1
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6V332 1018
organism: Macaca mulatta

uniprot Q62101 1210
type: UnificationXref
id: Q62101
db: uniprot

GRB2-associated-binding protein 1
type: ProteinReference
xref: uniprot F6YPY3 1056
organism: Xenopus tropicalis

uniprot P93003 512
type: UnificationXref
id: P93003
db: uniprot

TRANSCRIPTION
type: RelationshipTypeVocabulary

uniprot F7E5M4 419
type: UnificationXref
id: F7E5M4
db: uniprot

uniprot Q8MXI4 1038
type: UnificationXref
id: Q8MXI4
db: uniprot

uniprot Q04970 682
type: UnificationXref
id: Q04970
db: uniprot

PARTICIPANT STOICHIOMETRY r17 1267
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

uniprot Q5M824 754
type: UnificationXref
id: Q5M824
db: uniprot

PARTICIPANT STOICHIOMETRY r17 1266
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 1.0

uniprot Q5SW28 865
type: UnificationXref
id: Q5SW28
db: uniprot

Serine/threonine-protein kinase dkf-2
type: ProteinReference
xref: uniprot O45818 1171
organism: Caenorhabditis elegans

Rac-like GTP-binding protein 3
type: ProteinReference
xref: uniprot Q6Z808 1118
organism: Oryza sativa

uniprot F6Y9I6 1155
type: UnificationXref
id: F6Y9I6
db: uniprot

uniprot Q10N20 254
type: UnificationXref
id: Q10N20
db: uniprot

Serine/threonine-protein phosphatase PP2A catalytic subunit
type: ProteinReference
xref: uniprot Q9HFQ2 486
organism: Emericella nidulans

Akt
type: Protein
entity reference: Akt
feature: ACTIVE 167
feature: Akt s22 a25 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot F1P258 199
type: UnificationXref
id: F1P258
db: uniprot

uniprot P54632 91
type: UnificationXref
id: P54632
db: uniprot

uniprot P61981 93
type: UnificationXref
id: P61981
db: uniprot

uniprot F7GEK1 603
type: UnificationXref
id: F7GEK1
db: uniprot

Protein BMH2
type: ProteinReference
xref: uniprot P34730 80
xref: PTHR18860:SF17
organism: Saccharomyces cerevisiae

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot F1QNG4 641
organism: Danio rerio

14-3-3-like protein 1
type: ProteinReference
xref: uniprot P41932 83
xref: PTHR18860:SF21
organism: Caenorhabditis elegans

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 89

uniprot Q28EW2 684
type: UnificationXref
id: Q28EW2
db: uniprot

uniprot E7F354 30
type: UnificationXref
id: E7F354
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF60
xref: uniprot F7GZA8 351
organism: Macaca mulatta

uniprot A7Z057 11
type: UnificationXref
id: A7Z057
db: uniprot

uniprot F6U7A6 412
type: UnificationXref
id: F6U7A6
db: uniprot

uniprot P34885 1189
type: UnificationXref
id: P34885
db: uniprot

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot A0A3S5ZPX3 906
xref: PTHR48013:SF8
organism: Bos taurus

uniprot F7A632 1156
type: UnificationXref
id: F7A632
db: uniprot

uniprot Q15759 1033
type: UnificationXref
id: Q15759
db: uniprot

uniprot P61983 95
type: UnificationXref
id: P61983
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot P09217 1179
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r23 1300
type: Stoichiometry
physical entity: MKK4,7
stoichiometric coefficient: 1.0

Phosphatidylinositol 3-kinase VPS34-like
type: ProteinReference
xref: uniprot P54676 861
xref: PTHR10048:SF7
organism: Dictyostelium discoideum

uniprot Q5EBB0 122
type: UnificationXref
id: Q5EBB0
db: uniprot

PARTICIPANT STOICHIOMETRY r23 1301
type: Stoichiometry
physical entity: MKK4,7
stoichiometric coefficient: 1.0

Protein kinase C delta type
type: ProteinReference
xref: uniprot P09215 1178
xref: PTHR24356:SF365
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase 3
type: ProteinReference
xref: uniprot P54675 860
xref: PTHR10048:SF48
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MYM3 819
xref: PTHR10048:SF33
organism: Bos taurus

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot Q9VB23 490
organism: Drosophila melanogaster

Phosphatidylinositol 3-kinase 2
type: ProteinReference
xref: PTHR10048:SF109
xref: uniprot P54674 859
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot P54673 858
organism: Dictyostelium discoideum

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q6Z437 271
organism: Oryza sativa

uniprot F1M7Y5 1148
type: UnificationXref
id: F1M7Y5
db: uniprot

uniprot P54673 858
type: UnificationXref
id: P54673
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P10686 788
organism: Rattus norvegicus

uniprot E1BQN6 1141
type: UnificationXref
id: E1BQN6
db: uniprot

Receptor tyrosine-protein kinase erbB-2
type: ProteinReference
xref: PTHR24416:SF137
xref: uniprot O18735 205
organism: Canis lupus familiaris

uniprot Q07292 959
type: UnificationXref
id: Q07292
db: uniprot

uniprot F7FGD2 1160
type: UnificationXref
id: F7FGD2
db: uniprot

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P34722 1188
xref: PTHR24356:SF347
organism: Caenorhabditis elegans

uniprot Q8IS18 903
type: UnificationXref
id: Q8IS18
db: uniprot

Phosphatidylethanolamine-binding protein 4
type: ProteinReference
xref: uniprot Q96S96 524
organism: Homo sapiens

uniprot P48030 566
type: UnificationXref
id: P48030
db: uniprot

uniprot E2RSB0 1016
type: UnificationXref
id: E2RSB0
db: uniprot

Ras guanine nucleotide exchange factor K
type: ProteinReference
xref: uniprot Q54FF3 897
organism: Dictyostelium discoideum

uniprot F6QP11 599
type: UnificationXref
id: F6QP11
db: uniprot

GRB2-associated-binding protein 1
type: ProteinReference
xref: uniprot Q9QYY0 1068
xref: PTHR45960:SF5
organism: Mus musculus

PTHR45619:SF42
type: RelationshipXref
id: PTHR45619:SF42
db: PANTHER Family
relationship type: By Homology

Pleckstrin homology like domain family B member 2
type: ProteinReference
xref: uniprot A0A3Q1LNS5 1051
organism: Bos taurus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A7T2Q5 386
xref: PTHR45619:SF12
organism: Nematostella vectensis

uniprot P34146 1095
type: UnificationXref
id: P34146
db: uniprot

uniprot Q05655 1202
type: UnificationXref
id: Q05655
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7H3B3 1162
xref: PTHR24356:SF162
organism: Macaca mulatta

uniprot A0NBA9 806
type: UnificationXref
id: A0NBA9
db: uniprot

uniprot O04375 430
type: UnificationXref
id: O04375
db: uniprot

GAP
type: ProteinReference
xref: P00546
standard name: GTPase-Activating Protein
comment: ENTITY_REFERENCE_NOTES=Long Name: GAP Synonym: Synonym not specified Accession: P00546
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.GAP
member entity reference: Neurofibromin
member entity reference: Ras GTPase-activating protein 4
member entity reference: Ras GTPase-activating protein 1
member entity reference: Disabled homolog 2-interacting protein
member entity reference: Ras GTPase-activating protein 2
member entity reference: DAB2 interacting protein
member entity reference: Uncharacterized protein
member entity reference: RasGAP-activating-like protein 1
member entity reference: NF1 isoform 1
member entity reference: RAS protein activator like 2
member entity reference: GH13542p
member entity reference: RAS p21 protein activator (GTPase activating protein) 1
member entity reference: Neurofibromin 1, isoform B
member entity reference: Ras GTPase-activating protein 4B
member entity reference: AGAP002729-PA
member entity reference: RAS p21 protein activator 1
member entity reference: RAS protein activator-like 2
member entity reference: GTPase-activating protein
member entity reference: RAS p21 protein activator 2
member entity reference: Neurofibromin 1
member entity reference: Ras GTPase-activating protein nGAP

PTHR24072:SF127
type: RelationshipXref
id: PTHR24072:SF127
db: PANTHER Family
relationship type: By Homology

PTHR45619:SF44
type: RelationshipXref
id: PTHR45619:SF44
db: PANTHER Family
relationship type: By Homology

uniprot O16264 506
type: UnificationXref
id: O16264
db: uniprot

uniprot Q5HZA2 187
type: UnificationXref
id: Q5HZA2
db: uniprot

Phosphatidylethanolamine-binding protein 1
type: ProteinReference
xref: PTHR11362:SF109
xref: uniprot P30086 508
organism: Homo sapiens

uniprot Q13588 583
type: UnificationXref
id: Q13588
db: uniprot

uniprot F1QLX2 783
type: UnificationXref
id: F1QLX2
db: uniprot

uniprot E2R5G6 633
type: UnificationXref
id: E2R5G6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QJY6 800
xref: PTHR10048:SF28
organism: Macaca mulatta

Protein kinase C delta type
type: ProteinReference
xref: uniprot H9EU39 1169
xref: PTHR24356:SF365
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: PTHR24361:SF342
xref: uniprot F6YLW2 709
organism: Macaca mulatta

uniprot Q9HFQ2 486
type: UnificationXref
id: Q9HFQ2
db: uniprot

Phosphoinositide 3-kinase regulatory subunit 5
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot Q8WYR1 875
organism: Homo sapiens

PTHR12365:SF10
type: RelationshipXref
id: PTHR12365:SF10
db: PANTHER Family
relationship type: By Homology

uniprot Q14738 457
type: UnificationXref
id: Q14738
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q3T0N5 1036
organism: Bos taurus

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
controller: PP2A

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A3Q1M8V3 339
type: UnificationXref
id: A0A3Q1M8V3
db: uniprot

Rac-like GTP-binding protein 7
type: ProteinReference
xref: uniprot Q6Z7L8 1117
organism: Oryza sativa

Raf 1 s24 a27 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.725031289256469

GAP
type: Protein
entity reference: GAP
feature: ACTIVE 167
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa16 1246
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PKC
type: ProteinReference
xref: P00565
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.PKC
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: PKC Synonym: Synonym not specified Accession: P00565
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C zeta type
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C iota type
member entity reference: Serine/threonine-protein kinase D2
member entity reference: Serine/threonine-protein kinase dkf-2
member entity reference: Protein kinase C, brain isozyme
member entity reference: Serine/threonine-protein kinase
member entity reference: AGAP012252-PA (Fragment)
member entity reference: Protein kinase C-like 1
member entity reference: Serine/threonine-protein kinase D3
member entity reference: Protein kinase C eta type
member entity reference: Protein kinase C-like 1B
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C theta type
member entity reference: Serine/threonine-protein kinase D1
member entity reference: Protein kinase C-like 3
member entity reference: Protein kinase C gamma type (Fragment)
member entity reference: Protein kinase C-like

uniprot E1C6T4 1143
type: UnificationXref
id: E1C6T4
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P67775 447
xref: PTHR45619:SF42
organism: Homo sapiens

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s139 sa2 1228
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P67774 446
xref: PTHR45619:SF42
organism: Bos taurus

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot F1NHL1 1152
xref: PTHR22968:SF9
organism: Gallus gallus

SHC-transforming protein 2
type: ProteinReference
xref: uniprot P98077 751
xref: PTHR10337:SF5
organism: Homo sapiens

uniprot C4LXB1 23
type: UnificationXref
id: C4LXB1
db: uniprot

uniprot A5D7L6 622
type: UnificationXref
id: A5D7L6
db: uniprot

uniprot Q8NEB9 874
type: UnificationXref
id: Q8NEB9
db: uniprot

uniprot Q9VK60 534
type: UnificationXref
id: Q9VK60
db: uniprot

uniprot H2QD19 984
type: UnificationXref
id: H2QD19
db: uniprot

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q28EW2 684
organism: Xenopus tropicalis

Sprouty RTK signaling antagonist 4
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot F1Q4C2 175
organism: Canis lupus familiaris

uniprot P23636 435
type: UnificationXref
id: P23636
db: uniprot

EGFR s1 sa3 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.271642349477033
comment: MODIFICATION_RESIDUE_NAME=

Phosphoinositide-3-kinase, regulatory subunit 5
type: ProteinReference
xref: uniprot D4A4I3 810
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0R4IKK9 304
xref: PTHR24055:SF162
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot E9I1I7 634
xref: PTHR24070:SF420
organism: Daphnia pulex

Raf 1 s24 a27 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.67009388371117
comment: MODIFICATION_RESIDUE_NAME=

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot Q8CIH5 795
organism: Mus musculus

uniprot Q7ZUQ2 476
type: UnificationXref
id: Q7ZUQ2
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MYJ4 595
xref: PTHR24356:SF190
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2U980 621
organism: Gallus gallus

uniprot Q9C9U4 278
type: UnificationXref
id: Q9C9U4
db: uniprot

uniprot F1QU39 176
type: UnificationXref
id: F1QU39
db: uniprot

E3 ubiquitin-protein ligase CBL-B
type: ProteinReference
xref: uniprot Q13191 297
xref: PTHR23007:SF3
organism: Homo sapiens

uniprot F7CP86 418
type: UnificationXref
id: F7CP86
db: uniprot

Ras GTPase-activating protein 2
type: ProteinReference
xref: PTHR10194:SF21
xref: uniprot Q15283 363
organism: Homo sapiens

Candida albicans
type: BioSource
xref: ncbitaxon 237561 69

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

uniprot Q54FF3 897
type: UnificationXref
id: Q54FF3
db: uniprot

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

uniprot P62260 98
type: UnificationXref
id: P62260
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1M182 543
organism: Rattus norvegicus

ncbitaxon 7227 75
type: UnificationXref
id: 7227
db: ncbitaxon

SHC-transforming protein 1
type: ProteinReference
xref: uniprot P98083 752
xref: PTHR10337:SF2
organism: Mus musculus

MEKK1-5
type: Protein
entity reference: MEKK1-5
feature: ACTIVE 167
feature: MEKK1 5 s49 a61 rs2
feature: MEKK1 5 s49 a61 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q75LC7 472
type: UnificationXref
id: Q75LC7
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RJX4 593
xref: PTHR24356:SF171
organism: Canis lupus familiaris

uniprot A7STP5 626
type: UnificationXref
id: A7STP5
db: uniprot

14-3-3-like protein
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P54632 91
organism: Dictyostelium discoideum

CENTRORADIALIS, putative, expressed
type: ProteinReference
xref: uniprot Q2QXL9 515
organism: Oryza sativa

uniprot Q0P594 453
type: UnificationXref
id: Q0P594
db: uniprot

PTHR45619:SF12
type: RelationshipXref
id: PTHR45619:SF12
db: PANTHER Family
relationship type: By Homology

EGFR s1 sa3 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.8660799645249737

Leishmania major
type: BioSource
xref: ncbitaxon 5664 262

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot H2QNG6 840
xref: PTHR10048:SF33
organism: Pan troglodytes

uniprot P48347 87
type: UnificationXref
id: P48347
db: uniprot

MRAS isoform 2
type: ProteinReference
xref: uniprot H2QNG3 652
organism: Pan troglodytes

uniprot A0A1D5QJY6 800
type: UnificationXref
id: A0A1D5QJY6
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1Q4F8 597
xref: PTHR24356:SF190
organism: Canis lupus familiaris

uniprot B1NA68 764
type: UnificationXref
id: B1NA68
db: uniprot

uniprot Q61411 690
type: UnificationXref
id: Q61411
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot A7F3M0 227
organism: Sclerotinia sclerotiorum

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot F1NLM6 406
organism: Gallus gallus

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot G2HI54 61
xref: PTHR18860:SF67
organism: Pan troglodytes

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 15

uniprot A0A1D5Q7W8 336
type: UnificationXref
id: A0A1D5Q7W8
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot A0A0G2K3R1 695
organism: Rattus norvegicus

uniprot H2QLJ0 64
type: UnificationXref
id: H2QLJ0
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q04759 1200
organism: Homo sapiens

ncbitaxon 44689 92
type: UnificationXref
id: 44689
db: ncbitaxon

Protein kinase C
type: ProteinReference
xref: uniprot A0A3Q1MSP9 1134
xref: PTHR24356:SF170
organism: Bos taurus

uniprot A0A1D5QJ66 696
type: UnificationXref
id: A0A1D5QJ66
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7GN93 319
xref: PTHR24055:SF162
organism: Macaca mulatta

uniprot A0NBC2 9
type: UnificationXref
id: A0NBC2
db: uniprot

EGFR s1 sa3 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.29874869898594847
comment: MODIFICATION_RESIDUE_NAME=

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q7PD38 473
xref: PTHR45619:SF12
organism: Anopheles gambiae

STATE_TRANSITION_LEFT__MKK3,6-RIGHT__MKK3,6-_r25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1297
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1296
left: MKK3,6
interaction type: STATE_TRANSITION
right: MKK3,6

uniprot A0A2I3RG08 744
type: UnificationXref
id: A0A2I3RG08
db: uniprot

Raf 1 s24 a27 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=2.573915409637556
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

uniprot Q62245 901
type: UnificationXref
id: Q62245
db: uniprot

uniprot Q7ZUS7 477
type: UnificationXref
id: Q7ZUS7
db: uniprot

Proheparin-binding EGF-like growth factor
type: ProteinReference
xref: uniprot Q9W7C5 577
xref: PTHR10740:SF4
organism: Gallus gallus

uniprot Q9Z268 373
type: UnificationXref
id: Q9Z268
db: uniprot

uniprot P15514 561
type: UnificationXref
id: P15514
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot B3S653 394
xref: PTHR45619:SF12
organism: Trichoplax adhaerens

uniprot Q9I7L3 527
type: UnificationXref
id: Q9I7L3
db: uniprot

uniprot Q8K1N2 1065
type: UnificationXref
id: Q8K1N2
db: uniprot

uniprot Q9VXH3 796
type: UnificationXref
id: Q9VXH3
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot F1MGJ4 971
organism: Bos taurus

GH25425p
type: ProteinReference
xref: uniprot Q9VK60 534
organism: Drosophila melanogaster

Serine/threonine-protein phosphatase PP2A-5 catalytic subunit
type: ProteinReference
xref: uniprot O04951 432
organism: Arabidopsis thaliana

STATE_TRANSITION_LEFT__MKK4,7-RIGHT__MKK4,7-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1300
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1301
left: MKK4,7
interaction type: STATE_TRANSITION
right: MKK4,7

uniprot F7H3B3 1162
type: UnificationXref
id: F7H3B3
db: uniprot

uniprot C0H4V6 21
type: UnificationXref
id: C0H4V6
db: uniprot

uniprot Q7QEQ3 1007
type: UnificationXref
id: Q7QEQ3
db: uniprot

uniprot Q14765 1001
type: UnificationXref
id: Q14765
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7CW94 981
xref: PTHR11801:SF19
organism: Monodelphis domestica

uniprot O82481 1090
type: UnificationXref
id: O82481
db: uniprot

RAS related
type: ProteinReference
xref: uniprot K7CW85 654
xref: PTHR24070:SF245
organism: Pan troglodytes

uniprot Q5QNB8 128
type: UnificationXref
id: Q5QNB8
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 949
xref: PTHR44329:SF22
xref: uniprot P04049 948
organism: Homo sapiens

Pro-neuregulin-1, membrane-bound isoform
type: ProteinReference
xref: uniprot Q02297 569
organism: Homo sapiens

…
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

uniprot F6VAQ8 825
type: UnificationXref
id: F6VAQ8
db: uniprot

EGF receptor signaling pathway
type: Pathway
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__EGFR-RIGHT__EGFR-_r56
pathway component: STATE_TRANSITION_LEFT__EGFR-RIGHT__EGFR-_r17
pathway component: STATE_TRANSITION_LEFT__EGFR-RIGHT__EGFR-_r18
pathway component: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r7
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r6
pathway component: STATE_TRANSITION_LEFT__MKK4,7-RIGHT__MKK4,7-_r23
pathway component: STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r19
pathway component: STATE_TRANSITION_LEFT__ERK1_2-RIGHT__ERK1_2-_r14
pathway component: TRANSCRIPTION_LEFT__SPRY-RIGHT__SPRY-_re29
pathway component: STATE_TRANSITION_LEFT__RKIP-RIGHT__RKIP-_r11
pathway component: HETERODIMER_ASSOCIATION_LEFT__STAT-_PI3K-_PLCgamma-_SHC-_GAP-_Gab-_Complex__Grb2_SOS_-_EGFR-RIGHT__Complex__EGFR_PLC_gamma__STAT_PI3K__SHC_Gab__Grb2_SOS__GAP_-_r64
pathway component: HETERODIMER_ASSOCIATION_LEFT__SOS-_Grb2-RIGHT__Complex__Grb2_SOS_-_r57
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Grb2_SOS_-_EGFR-RIGHT__Complex__EGFR_Grb2__SOS_-_r58
pathway component: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r21
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__MEKK1_5-RIGHT__MEKK1_5-_r22
pathway component: TRANSLATION_LEFT__SPRY-RIGHT__Spry-_re30
pathway component: STATE_TRANSITION_LEFT__p38-RIGHT__p38-_r26
pathway component: STATE_TRANSITION_LEFT__MEK1_2-RIGHT__MEK1_2-_r9
pathway component: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
pathway component: STATE_TRANSITION_LEFT__JNK1_3-RIGHT__JNK1_3-_r24
pathway component: STATE_TRANSITION_LEFT__MKK3,6-RIGHT__MKK3,6-_r25
pathway component: STATE_TRANSITION_LEFT__EGFR-RIGHT__a87_degraded-_r59
pathway component: STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r4
xref: PANTHER Pathway P00018 1
comment: MODEL_NOTES=Panther Pathway: P00018 EGFR belongs to the human epidermal receptor (HER) family of receptor tyrosine kinases, which consists of four closely related receptors (EGFR (HER1, erbB1), HER2 (neu, erbB2), HER3 (erbB3), and HER4 (erbB4)) that mediate cellular signaling pathways involved in growth and proliferation in response to the binding of a variety of growth factor ligands. There are currently six known endogenous ligands for EGFR: EGF, transforming growth factor- (TGF-), amphiregulin, betacellulin, heparin-binding EGF (HB-EGF), and epiregulin.Upon ligand binding, the EGFR forms homo- or heterodimeric complexes (usually with HER2), which leads to activation of the receptor tyrosine kinase, via autophosphorylation. Medline=12813928 Medline=14527402 Medline=14561424 Medline=14766123 PMID: 12813928 PMID: 14527402 PMID: 14561424 PMID: 14766123

PARTICIPANT STOICHIOMETRY r9 1269
type: Stoichiometry
physical entity: MEK1-2
stoichiometric coefficient: 1.0

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C3YJC1 1075
organism: Branchiostoma floridae

PARTICIPANT STOICHIOMETRY r9 1268
type: Stoichiometry
physical entity: MEK1-2
stoichiometric coefficient: 1.0

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

SOS
type: Protein
entity reference: SOS
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P79996 329
organism: Gallus gallus

uniprot Q53Q71 517
type: UnificationXref
id: Q53Q71
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9XW37 535
organism: Caenorhabditis elegans

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63001 1103
xref: PTHR24072:SF105
organism: Mus musculus

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63000 1102
xref: PTHR24072:SF105
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot F6TY10 46
organism: Monodelphis domestica

uniprot F1PNW8 974
type: UnificationXref
id: F1PNW8
db: uniprot

eco ECO:0000316 15
type: UnificationXref
id: ECO:0000316
db: eco

uniprot H2QRH7 426
type: UnificationXref
id: H2QRH7
db: uniprot

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: PTHR24361:SF342
xref: uniprot Q9Y2U5 741
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: uniprot A8WR64 1137
xref: PTHR24356:SF347
organism: Caenorhabditis briggsae

14-3-3-like protein GF14 upsilon
type: ProteinReference
xref: PTHR18860:SF101
xref: uniprot P42645 86
organism: Arabidopsis thaliana

14-3-3
type: Protein
entity reference: 14-3-3
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot A0A1D5Q575 168
organism: Macaca mulatta

Ras GTPase-activating protein 4B
type: ProteinReference
xref: uniprot C9J798 341
xref: PTHR10194:SF4
organism: Homo sapiens

uniprot E2RLD1 815
type: UnificationXref
id: E2RLD1
db: uniprot

14-3-3-like protein GF14 psi
type: ProteinReference
xref: uniprot P42644 85
xref: PTHR18860:SF95
organism: Arabidopsis thaliana

uniprot Q80W83 479
type: UnificationXref
id: Q80W83
db: uniprot

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

GAP s15 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GAP
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q7QK56 613
organism: Anopheles gambiae

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot F7C798 1021
organism: Macaca mulatta

Protein kinase C-like 3
type: ProteinReference
xref: PTHR24356:SF303
xref: uniprot Q19266 1205
organism: Caenorhabditis elegans

General regulatory factor 13
type: ProteinReference
xref: uniprot F4IA59 39
organism: Arabidopsis thaliana

uniprot P42338 854
type: UnificationXref
id: P42338
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A2I3T9Y4 590
xref: PTHR24356:SF190
organism: Pan troglodytes

Signal transducer and activator of transcription 2
type: ProteinReference
xref: uniprot Q9WVL2 1010
xref: PTHR11801:SF41
organism: Mus musculus

Gab s12 sa13 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=1.591660794133728

14-3-3 protein eta
type: ProteinReference
xref: uniprot F6RIX6 40
xref: PTHR18860:SF16
organism: Macaca mulatta

ncbitaxon 7719 45
type: UnificationXref
id: 7719
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GY91 1088
xref: PTHR24072:SF325
organism: Macaca mulatta

uniprot F6XFG9 48
type: UnificationXref
id: F6XFG9
db: uniprot

14-3-3 protein eta
type: ProteinReference
xref: uniprot Q04917 111
xref: PTHR18860:SF16
organism: Homo sapiens

uniprot Q7RVR1 273
type: UnificationXref
id: Q7RVR1
db: uniprot

uniprot Q12526 683
type: UnificationXref
id: Q12526
db: uniprot

Receptor tyrosine-protein kinase erbB-4
type: ProteinReference
xref: PTHR24416:SF90
xref: uniprot Q62956 218
organism: Rattus norvegicus

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

Receptor protein-tyrosine kinase
type: ProteinReference
xref: PTHR24416:SF90
xref: uniprot F1P258 199
organism: Gallus gallus

uniprot E7EXT6 594
type: UnificationXref
id: E7EXT6
db: uniprot

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

uniprot A8X1S0 310
type: UnificationXref
id: A8X1S0
db: uniprot

SHC
type: ProteinReference
xref: P00554
standard name: Src homology 2 domain-containing transforming protein 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.SHC
comment: ENTITY_REFERENCE_NOTES=Long Name: Src homology 2 domain-containing transforming protein 1 Synonym: pp46/52/66 Accession: P00554
member entity reference: SHC-transforming protein 2
member entity reference: SHC-transforming protein homolog 1
member entity reference: DShc protein
member entity reference: SHC adaptor protein 3
member entity reference: SHC-transforming protein 1
member entity reference: AGAP011463-PA
member entity reference: SHC-transforming protein 3
member entity reference: SHC (Src homology 2 domain containing) transforming protein 1
member entity reference: Uncharacterized protein

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QQ23 194
xref: PTHR24416:SF88
organism: Macaca mulatta

uniprot P42226 990
type: UnificationXref
id: P42226
db: uniprot

Pro-neuregulin-1, membrane-bound isoform
type: ProteinReference
xref: uniprot P43322 565
organism: Rattus norvegicus

uniprot Q61521 573
type: UnificationXref
id: Q61521
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F6PKB8 410
xref: PTHR10257:SF6
organism: Monodelphis domestica

uniprot H2Q7P2 180
type: UnificationXref
id: H2Q7P2
db: uniprot

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

Gab s12 sa13 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

MEKK1-5
type: Protein
entity reference: MEKK1-5
feature: MEKK1 5 s38 a40 rs1
feature: MEKK1 5 s38 a40 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q99759 738
type: UnificationXref
id: Q99759
db: uniprot

Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform
type: ProteinReference
xref: uniprot O04376 431
organism: Arabidopsis thaliana

SHC-transforming protein 3
type: ProteinReference
xref: uniprot Q61120 755
xref: PTHR10337:SF4
organism: Mus musculus

Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform
type: ProteinReference
xref: uniprot O04375 430
organism: Arabidopsis thaliana

uniprot Q5Y173 188
type: UnificationXref
id: Q5Y173
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
type: ProteinReference
xref: uniprot Q6PD03 469
xref: PTHR10257:SF6
organism: Mus musculus

Ras-related protein R-Ras
type: ProteinReference
xref: uniprot P10301 669
xref: PTHR24070:SF245
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR11362:SF82
xref: uniprot F7BYT3 503
organism: Macaca mulatta

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot O14733 769
xref: PTHR48013:SF17
organism: Homo sapiens

uniprot Q8BMC3 757
type: UnificationXref
id: Q8BMC3
db: uniprot

uniprot Q9UJF2 371
type: UnificationXref
id: Q9UJF2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot E1B847 700
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q19243 255
organism: Caenorhabditis elegans

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5QPR1 963
xref: PTHR11801:SF47
organism: Macaca mulatta

uniprot Q7PD38 473
type: UnificationXref
id: Q7PD38
db: uniprot

uniprot Q6P4Z5 135
type: UnificationXref
id: Q6P4Z5
db: uniprot

uniprot A0A2I3TK00 941
type: UnificationXref
id: A0A2I3TK00
db: uniprot

Pro-neuregulin-3, membrane-bound isoform
type: ProteinReference
xref: uniprot O35181 555
organism: Mus musculus

Phosphoinositide 3-kinase regulatory subunit 6
type: ProteinReference
xref: uniprot Q3U6Q4 863
organism: Mus musculus

uniprot Q9LUC3 281
type: UnificationXref
id: Q9LUC3
db: uniprot

Dual specificity mitogen-activated protein kinase kinase mek-2
type: ProteinReference
xref: uniprot Q10664 922
xref: PTHR48013:SF19
organism: Caenorhabditis elegans

RKIP s30 a33 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot K7D3K8 985
xref: PTHR11801:SF48
organism: Pan troglodytes

Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1
type: ProteinReference
xref: uniprot O18178 433
organism: Caenorhabditis elegans

uniprot F1PIZ0 348
type: UnificationXref
id: F1PIZ0
db: uniprot

uniprot F1MGJ4 971
type: UnificationXref
id: F1MGJ4
db: uniprot

ncbitaxon 6669 33
type: UnificationXref
id: 6669
db: ncbitaxon

Protein sprouty homolog 3
type: ProteinReference
xref: uniprot O43610 185
organism: Homo sapiens

uniprot Q4QHJ8 264
type: UnificationXref
id: Q4QHJ8
db: uniprot

ERK1 2 s28 a31 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot P31749 606
type: UnificationXref
id: P31749
db: uniprot

Rac-like GTP-binding protein 6
type: ProteinReference
xref: PTHR24072:SF287
xref: uniprot Q6ZHA3 1119
organism: Oryza sativa

uniprot Q9ZNV5 536
type: UnificationXref
id: Q9ZNV5
db: uniprot

Rac-like GTP-binding protein ARAC10
type: ProteinReference
xref: uniprot O82481 1090
organism: Arabidopsis thaliana

Rac-like GTP-binding protein ARAC7
type: ProteinReference
xref: PTHR24072:SF127
xref: uniprot O82480 1089
organism: Arabidopsis thaliana

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 8

p38 s54 a67 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 167
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P52630 997
type: UnificationXref
id: P52630
db: uniprot

uniprot H9FU32 947
type: UnificationXref
id: H9FU32
db: uniprot

p38 s53 a66 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q15759 1033
organism: Homo sapiens

Raf 1 s23 a26 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=5.67009388371117
comment: MODIFICATION_RESIDUE_NAME=

uniprot F1PHV7 640
type: UnificationXref
id: F1PHV7
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 939
evidence: Evidence 936
evidence: Evidence 937
evidence: Evidence 938
xref: PTHR44329:SF22
xref: uniprot A0A1D5R9U8 935
organism: Macaca mulatta

Gab s12 sa13 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot P68510 107
type: UnificationXref
id: P68510
db: uniprot

Protein sprouty homolog 1
type: ProteinReference
xref: PTHR12365:SF10
xref: uniprot O43609 184
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q7KQK7 272
xref: PTHR24055:SF189
organism: Plasmodium falciparum

p38 s53 a66 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot Q06186 572
type: UnificationXref
id: Q06186
db: uniprot

ERK1 2 s28 a31 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

MAP kinase kinase skh1/pek1
type: ProteinReference
xref: uniprot Q9Y884 933
organism: Schizosaccharomyces pombe

p38 s54 a67 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot F7BU66 55
type: UnificationXref
id: F7BU66
db: uniprot

Raf 1 s23 a26 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.725031289256469

Protein HEADING DATE 3A
type: ProteinReference
xref: uniprot Q93WI9 523
organism: Oryza sativa

uniprot A5D992 170
type: UnificationXref
id: A5D992
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK1_2-RIGHT__ERK1_2-_r14
controller: MEK1-2

uniprot Q6RUV5 1116
type: UnificationXref
id: Q6RUV5
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot F1P750 705
xref: PTHR24361:SF656
organism: Canis lupus familiaris

uniprot P08646 666
type: UnificationXref
id: P08646
db: uniprot

Raf homolog serine/threonine-protein kinase Raf
type: ProteinReference
xref: uniprot P11346 955
organism: Drosophila melanogaster

RAS related
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot E2R5G6 633
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot Q61151 465
organism: Mus musculus

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 954
xref: PTHR44329:SF22
xref: uniprot P11345 953
organism: Rattus norvegicus

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

Sprouty RTK signaling antagonist 2
type: DnaReference
xref: PTHR12365:SF8
organism: Pan troglodytes

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

uniprot F7CHH2 980
type: UnificationXref
id: F7CHH2
db: uniprot

uniprot Q9FJV0 930
type: UnificationXref
id: Q9FJV0
db: uniprot

uniprot Q63932 928
type: UnificationXref
id: Q63932
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot O15264 1024
xref: PTHR24055:SF107
organism: Homo sapiens

uniprot H2PXY8 838
type: UnificationXref
id: H2PXY8
db: uniprot

uniprot E2RIF9 814
type: UnificationXref
id: E2RIF9
db: uniprot

uniprot F6PR50 707
type: UnificationXref
id: F6PR50
db: uniprot

uniprot E2QZT7 29
type: UnificationXref
id: E2QZT7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2KZI0 320
organism: Caenorhabditis elegans

RCG49355
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot D3ZJA3 172
organism: Rattus norvegicus

uniprot O08989 656
type: UnificationXref
id: O08989
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot F6RA79 1153
organism: Monodelphis domestica

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F1RB17 821
organism: Danio rerio

uniprot Q380S1 516
type: UnificationXref
id: Q380S1
db: uniprot

Receptor protein-tyrosine kinase
type: ProteinReference
xref: uniprot K7DJM0 204
xref: PTHR24416:SF137
organism: Pan troglodytes

uniprot P35070 564
type: UnificationXref
id: P35070
db: uniprot

uniprot P27348 72
type: UnificationXref
id: P27348
db: uniprot

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

GTPase NRas
type: ProteinReference
xref: uniprot Q04970 682
xref: PTHR24070:SF189
organism: Rattus norvegicus

Raf 1 s23 a26 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.5815230303900968
comment: MODIFICATION_RESIDUE_NAME=

uniprot H2QQ50 181
type: UnificationXref
id: H2QQ50
db: uniprot

Ras-like protein rasD
type: ProteinReference
xref: uniprot P03967 662
xref: PTHR24070:SF418
organism: Dictyostelium discoideum

uniprot O94806 1172
type: UnificationXref
id: O94806
db: uniprot

uniprot Q99075 575
type: UnificationXref
id: Q99075
db: uniprot

MKK3,6
type: ProteinReference
xref: P00540
standard name: Dual specificity mitogen-activated protein kinase kinase 3 and 6
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.MKK3,6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Dual specificity mitogen-activated protein kinase kinase 3 and 6 Synonym: MAP kinase kinase 3 and 6,MAPK/ERK kinase 3 and 6,MAPKK 3 and 6 Accession: P00540
member entity reference: Mitogen-activated protein kinase kinase 6
member entity reference: AGAP000310-PA
member entity reference: Dual specificity mitogen-activated protein kinase kinase 3
member entity reference: Dual specificity mitogen-activated protein kinase kinase 6
member entity reference: Mitogen-activated protein kinase kinase 3
member entity reference: Uncharacterized protein
member entity reference: Map2k3 protein

uniprot F6S9S9 909
type: UnificationXref
id: F6S9S9
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q07890 896
xref: PTHR23113:SF150
organism: Homo sapiens

uniprot P47196 609
type: UnificationXref
id: P47196
db: uniprot

uniprot H9EU39 1169
type: UnificationXref
id: H9EU39
db: uniprot

uniprot A0A0G2K344 797
type: UnificationXref
id: A0A0G2K344
db: uniprot

PARTICIPANT STOICHIOMETRY r24 1299
type: Stoichiometry
physical entity: JNK1-3
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M864 1052
xref: PTHR45960:SF1
organism: Bos taurus

JNK1 3 s40 a42 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PARTICIPANT STOICHIOMETRY r24 1298
type: Stoichiometry
physical entity: JNK1-3
stoichiometric coefficient: 1.0

ncbitaxon 3702 38
type: UnificationXref
id: 3702
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7B5L8 317
organism: Ornithorhynchus anatinus

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot K9J7P6 429
xref: PTHR10257:SF92
organism: Xenopus tropicalis

Receptor protein-tyrosine kinase
type: ProteinReference
xref: PTHR24416:SF91
xref: uniprot G3V6K6 203
organism: Rattus norvegicus

AGAP011463-PA
type: ProteinReference
xref: uniprot Q7Q334 756
organism: Anopheles gambiae

Phosphoinositide 3-kinase regulatory subunit 5
type: ProteinReference
xref: uniprot Q5SW28 865
organism: Mus musculus

ncbitaxon 36329 22
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot E2R275 542
type: UnificationXref
id: E2R275
db: uniprot

uniprot P27361 244
type: UnificationXref
id: P27361
db: uniprot

14-3-3 protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot Q5F3W6 123
organism: Gallus gallus

uniprot Q9XTG7 617
type: UnificationXref
id: Q9XTG7
db: uniprot

uniprot Q9VSK2 303
type: UnificationXref
id: Q9VSK2
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F1PAY3 973
xref: PTHR11801:SF48
organism: Canis lupus familiaris

Sprouty RTK-signaling antagonist 2
type: ProteinReference
xref: uniprot Q5HZA2 187
xref: PTHR12365:SF8
organism: Rattus norvegicus

uniprot P01111 658
type: UnificationXref
id: P01111
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2I3SED2 338
xref: PTHR10194:SF4
organism: Pan troglodytes

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot B7QGY5 396
xref: PTHR45619:SF12
organism: Ixodes scapularis

uniprot Q02111 1197
type: UnificationXref
id: Q02111
db: uniprot

uniprot O93599 986
type: UnificationXref
id: O93599
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F1Q6Z7 409
xref: PTHR45619:SF42
organism: Danio rerio

ncbitaxon 39947 113
type: UnificationXref
id: 39947
db: ncbitaxon

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 41

uniprot E1B7L9 1139
type: UnificationXref
id: E1B7L9
db: uniprot

uniprot Q8IR23 369
type: UnificationXref
id: Q8IR23
db: uniprot

Protein son of sevenless
type: ProteinReference
xref: uniprot P26675 892
xref: PTHR23113:SF341
organism: Drosophila melanogaster

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q9TU25 1129
organism: Bos taurus

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot E1B7L9 1139
organism: Bos taurus

uniprot F6YAB9 1019
type: UnificationXref
id: F6YAB9
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P04627 950
organism: Mus musculus

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: uniprot B1NA68 764
xref: PTHR48013:SF15
organism: Danio rerio

uniprot A0A1D5PXC6 305
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

uniprot Q5XGC8 129
type: UnificationXref
id: Q5XGC8
db: uniprot

uniprot O43609 184
type: UnificationXref
id: O43609
db: uniprot

uniprot P56975 568
type: UnificationXref
id: P56975
db: uniprot

RRAS2 protein
type: ProteinReference
xref: uniprot A5PKL2 624
organism: Bos taurus

Betacellulin
type: ProteinReference
xref: uniprot Q9JJM4 576
organism: Rattus norvegicus

PLCgamma s6 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PLCgamma
stoichiometric coefficient: 1.0

Raf 1 s23 a26 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=2.573915409637556
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5R9X3 965
xref: PTHR11801:SF18
organism: Macaca mulatta

PTHR24070:SF418
type: RelationshipXref
id: PTHR24070:SF418
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot F7GTQ2 1161
organism: Macaca mulatta

uniprot F6X0X1 414
type: UnificationXref
id: F6X0X1
db: uniprot

uniprot Q6NYS4 518
type: UnificationXref
id: Q6NYS4
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 937
xref: PTHR44329:SF22
xref: uniprot P05625 951
organism: Gallus gallus

uniprot A0A3Q1LWJ8 307
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

uniprot Q5CZQ1 121
type: UnificationXref
id: Q5CZQ1
db: uniprot

MEK1 2 s26 a29 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot E2R9L4 701
xref: PTHR48016:SF32
organism: Canis lupus familiaris

PTHR24361:SF342
type: RelationshipXref
id: PTHR24361:SF342
db: PANTHER Family
relationship type: By Homology

uniprot P10398 952
type: UnificationXref
id: P10398
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot P41743 1192
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot F1P714 407
organism: Canis lupus familiaris

ncbitaxon 13616 43
type: UnificationXref
id: 13616
db: ncbitaxon

Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform
type: ProteinReference
xref: uniprot Q8RW96 483
organism: Arabidopsis thaliana

Serine/threonine-protein phosphatase 6 catalytic subunit
type: ProteinReference
xref: uniprot Q9CQR6 485
organism: Mus musculus

SHC s11 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SHC
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot Q8SSU4 370
xref: PTHR10194:SF132
organism: Dictyostelium discoideum

AGAP013036-PA
type: ProteinReference
xref: uniprot F5HM76 500
organism: Anopheles gambiae

uniprot A0A1D5Q6M6 376
type: UnificationXref
id: A0A1D5Q6M6
db: uniprot

uniprot Q4Q0B0 261
type: UnificationXref
id: Q4Q0B0
db: uniprot

AGAP012962-PA
type: ProteinReference
xref: uniprot F5HM75 499
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DNM3 349
xref: PTHR10194:SF19
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1250
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1249
left: Rac
interaction type: STATE_TRANSITION
right: Rac

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: uniprot Q9DGE1 1041
xref: PTHR24055:SF110
organism: Danio rerio

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: uniprot Q9DGE2 1042
xref: PTHR24055:SF110
organism: Danio rerio

PTHR22968:SF26
type: RelationshipXref
id: PTHR22968:SF26
db: PANTHER Family
relationship type: By Homology

uniprot P62715 442
type: UnificationXref
id: P62715
db: uniprot

MEK1 2 s26 a29 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot F6SW23 822
type: UnificationXref
id: F6SW23
db: uniprot

PTHR24070:SF420
type: RelationshipXref
id: PTHR24070:SF420
db: PANTHER Family
relationship type: By Homology

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

Ras homolog family member J
type: ProteinReference
xref: uniprot F7B5I9 1086
organism: Xenopus tropicalis

JNK1 3 s40 a42 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot Q5XGC8 129
xref: PTHR18860:SF28
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F7EFF6 59
organism: Macaca mulatta

Transforming growth factor alpha
type: ProteinReference
xref: PTHR10740:SF1
xref: uniprot A0A2I3SQ00 539
organism: Pan troglodytes

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot O35904 846
organism: Mus musculus

uniprot H2QLB4 239
type: UnificationXref
id: H2QLB4
db: uniprot

uniprot F0ZQR3 1082
type: UnificationXref
id: F0ZQR3
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7HC75 1163
xref: PTHR24356:SF181
organism: Macaca mulatta

uniprot O70167 847
type: UnificationXref
id: O70167
db: uniprot

PTHR22968:SF12
type: RelationshipXref
id: PTHR22968:SF12
db: PANTHER Family
relationship type: By Homology

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot Q5ZMT0 133
xref: PTHR18860:SF17
organism: Gallus gallus

uniprot Q9TU25 1129
type: UnificationXref
id: Q9TU25
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot A0A3Q1LPF2 697
xref: PTHR24361:SF656
organism: Bos taurus

uniprot F6XSJ9 1085
type: UnificationXref
id: F6XSJ9
db: uniprot

CBL isoform 2
type: ProteinReference
xref: PTHR23007:SF5
xref: uniprot H2Q4Y2 293
organism: Pan troglodytes

EGFR s5 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HS52 1058
xref: PTHR45960:SF5
organism: Macaca mulatta

uniprot P53599 725
type: UnificationXref
id: P53599
db: uniprot

uniprot P49187 327
type: UnificationXref
id: P49187
db: uniprot

PARTICIPANT STOICHIOMETRY r59 1284
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 1285
type: Stoichiometry
physical entity: a87_degraded
stoichiometric coefficient: 1.0

EGFR
type: Protein
entity reference: EGFR
feature: ACTIVE 167
feature: EGFR s1 sa3 rs3
feature: EGFR s1 sa3 rs2
feature: EGFR s1 sa3 rs4
feature: EGFR s1 sa3 rs1

uniprot F1MHW1 344
type: UnificationXref
id: F1MHW1
db: uniprot

uniprot A0A3Q1MSP9 1134
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot D4A3T0 880
organism: Rattus norvegicus

PTHR10336:SF25
type: RelationshipXref
id: PTHR10336:SF25
db: PANTHER Family
relationship type: By Homology

uniprot Q7XTE8 143
type: UnificationXref
id: Q7XTE8
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q9Z0L5 579
type: UnificationXref
id: Q9Z0L5
db: uniprot

uniprot H2QVV5 505
type: UnificationXref
id: H2QVV5
db: uniprot

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 14

Cbl proto-oncogene
type: ProteinReference
xref: PTHR23007:SF5
xref: uniprot D3ZV15 289
organism: Rattus norvegicus

EGFR s129 a46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

uniprot K7DJM0 204
type: UnificationXref
id: K7DJM0
db: uniprot

PTHR10740:SF4
type: RelationshipXref
id: PTHR10740:SF4
db: PANTHER Family
relationship type: By Homology

PTHR10740:SF1
type: RelationshipXref
id: PTHR10740:SF1
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription 1-alpha/beta
type: ProteinReference
xref: uniprot P42224 988
xref: PTHR11801:SF18
organism: Homo sapiens

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot E2RIF9 814
organism: Canis lupus familiaris

uniprot Q75J93 692
type: UnificationXref
id: Q75J93
db: uniprot

GTP binding protein
type: ProteinReference
xref: uniprot G5EGA7 650
organism: Caenorhabditis elegans

uniprot K7CFQ9 716
type: UnificationXref
id: K7CFQ9
db: uniprot

AGAP002219-PA
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot Q7QK91 693
organism: Anopheles gambiae

uniprot F7BVQ1 785
type: UnificationXref
id: F7BVQ1
db: uniprot

uniprot F6RA79 1153
type: UnificationXref
id: F6RA79
db: uniprot

uniprot H2QCA7 768
type: UnificationXref
id: H2QCA7
db: uniprot

uniprot D3ZTF6 808
type: UnificationXref
id: D3ZTF6
db: uniprot

SFN isoform 1
type: ProteinReference
xref: uniprot H2RC87 66
xref: PTHR18860:SF14
organism: Pan troglodytes

uniprot F1NVA9 498
type: UnificationXref
id: F1NVA9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK1_3-RIGHT__JNK1_3-_r24
controller: MKK4,7

Similar to 14-3-3 protein sigma
type: ProteinReference
xref: uniprot Q5EBB0 122
xref: PTHR18860:SF14
organism: Rattus norvegicus

uniprot P63330 444
type: UnificationXref
id: P63330
db: uniprot

ncbitaxon 321614 233
type: UnificationXref
id: 321614
db: ncbitaxon

Mitogen-activated protein kinase mpk-1
type: ProteinReference
xref: uniprot P39745 249
xref: PTHR24055:SF158
organism: Caenorhabditis elegans

uniprot Q5ZLQ6 132
type: UnificationXref
id: Q5ZLQ6
db: uniprot

SPRY1 isoform 1
type: ProteinReference
xref: PTHR12365:SF10
xref: uniprot H2QQ50 181
organism: Pan troglodytes

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot F7EJU0 158
organism: Xenopus tropicalis

uniprot A7T2Q5 386
type: UnificationXref
id: A7T2Q5
db: uniprot

ncbitaxon 7739 398
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot Q06967 112
type: UnificationXref
id: Q06967
db: uniprot

EREG isoform 1
type: ProteinReference
xref: uniprot H2QPP3 549
organism: Pan troglodytes

Pro-epidermal growth factor
type: ProteinReference
xref: uniprot H2QQ13 551
organism: Pan troglodytes

uniprot A9JRY8 1073
type: UnificationXref
id: A9JRY8
db: uniprot

BTC isoform 1
type: ProteinReference
xref: uniprot H2QPP5 550
organism: Pan troglodytes

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: uniprot P42232 995
xref: PTHR11801:SF39
organism: Mus musculus

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: uniprot P42230 994
xref: PTHR11801:SF47
organism: Mus musculus

uniprot A9RVI2 389
type: UnificationXref
id: A9RVI2
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A2I3SHP7 778
organism: Pan troglodytes

Receptor tyrosine-protein kinase erbB-2
type: ProteinReference
xref: PTHR24416:SF137
xref: uniprot P04626 208
organism: Homo sapiens

uniprot Q9V3C8 760
type: UnificationXref
id: Q9V3C8
db: uniprot

uniprot Q6DRP4 735
type: UnificationXref
id: Q6DRP4
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot P15153 1092
organism: Homo sapiens

Putative 14-3-3 family protein BMH1
type: ProteinReference
xref: uniprot A0A0D1E7J2 3
xref: PTHR18860:SF17
organism: Ustilago maydis

Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform
type: ProteinReference
xref: uniprot Q9LU89 487
organism: Arabidopsis thaliana

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 17

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q8UUX0 615
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 84

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot F6V7D9 413
organism: Canis lupus familiaris

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: uniprot P42229 993
xref: PTHR11801:SF47
organism: Homo sapiens

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P42227 991
organism: Mus musculus

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot Q9CQV8 147
organism: Mus musculus

Signal transducer and activator of transcription 4
type: ProteinReference
xref: uniprot P42228 992
xref: PTHR11801:SF19
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YZJ5 1057
organism: Macaca mulatta

Signal transducer and activator of transcription 1
type: ProteinReference
xref: uniprot P42225 989
xref: PTHR11801:SF18
organism: Mus musculus

uniprot H2RC87 66
type: UnificationXref
id: H2RC87
db: uniprot

Signal transducer and activator of transcription 6
type: ProteinReference
xref: uniprot P42226 990
xref: PTHR11801:SF48
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q8BTI9 873
xref: PTHR10048:SF33
organism: Mus musculus

Receptor tyrosine-protein kinase erbB-4
type: ProteinReference
xref: PTHR24416:SF90
xref: uniprot Q15303 214
organism: Homo sapiens

uniprot Q7QCP8 1213
type: UnificationXref
id: Q7QCP8
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A1D5QTL2 964
xref: PTHR11801:SF19
organism: Macaca mulatta

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 939
evidence: Evidence 936
evidence: Evidence 937
evidence: Evidence 938
xref: PTHR44329:SF22
xref: uniprot E2REI6 944
organism: Canis lupus familiaris

Map3k3 protein
type: ProteinReference
xref: uniprot B5DF98 699
xref: PTHR24361:SF656
organism: Rattus norvegicus

uniprot P28867 1187
type: UnificationXref
id: P28867
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot Q07889 894
organism: Homo sapiens

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot O08911 1023
organism: Mus musculus

uniprot P50904 360
type: UnificationXref
id: P50904
db: uniprot

uniprot F1MIA2 1150
type: UnificationXref
id: F1MIA2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot D4A3U7 1014
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 230
organism: Canis lupus familiaris

ncbitaxon 5664 262
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot Q9QXV9 192
type: UnificationXref
id: Q9QXV9
db: uniprot

uniprot G3X7B5 604
type: UnificationXref
id: G3X7B5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r7
controller: Complex (EGFR/PLC_gamma/ STAT/PI3K/ SHC/Gab/ Grb2/SOS/ GAP)

uniprot O00443 843
type: UnificationXref
id: O00443
db: uniprot

uniprot P79737 679
type: UnificationXref
id: P79737
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot O09110 160
organism: Mus musculus

PTHR18860:SF7
type: RelationshipXref
id: PTHR18860:SF7
db: PANTHER Family
relationship type: By Homology

EGFR s5 sa8 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.8660799645249737

PTHR18860:SF3
type: RelationshipXref
id: PTHR18860:SF3
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3SED2 338
type: UnificationXref
id: A0A2I3SED2
db: uniprot

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
type: ProteinReference
xref: uniprot D3ZVF3 809
xref: PTHR10048:SF30
organism: Rattus norvegicus

SHC s11 sa12 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot K9J7P6 429
type: UnificationXref
id: K9J7P6
db: uniprot

uniprot Q387R2 256
type: UnificationXref
id: Q387R2
db: uniprot

uniprot Q6YX33 471
type: UnificationXref
id: Q6YX33
db: uniprot

uniprot A8X0X5 627
type: UnificationXref
id: A8X0X5
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot P32871 851
organism: Bos taurus

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F1PBB6 765
organism: Canis lupus familiaris

uniprot F7H808 422
type: UnificationXref
id: F7H808
db: uniprot

uniprot H2QCM0 352
type: UnificationXref
id: H2QCM0
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot F7FGD2 1160
organism: Monodelphis domestica

uniprot Q62077 794
type: UnificationXref
id: Q62077
db: uniprot

EGFR
type: Protein
entity reference: EGFR
feature: EGFR s129 a46 rs2
feature: ACTIVE 167
feature: EGFR s129 a46 rs1
feature: EGFR s129 a46 rs4
feature: EGFR s129 a46 rs3

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 126

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A3Q1MM63 380
xref: PTHR10257:SF19
organism: Bos taurus

uniprot P70236 163
type: UnificationXref
id: P70236
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot E1BE66 812
organism: Bos taurus

uniprot H9FYU7 890
type: UnificationXref
id: H9FYU7
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q90XF2 1216
organism: Danio rerio

uniprot Q74ZU1 138
type: UnificationXref
id: Q74ZU1
db: uniprot

PTHR11801:SF19
type: RelationshipXref
id: PTHR11801:SF19
db: PANTHER Family
relationship type: By Homology

PTHR11801:SF18
type: RelationshipXref
id: PTHR11801:SF18
db: PANTHER Family
relationship type: By Homology

GTP binding protein
type: ProteinReference
xref: uniprot G5EBK8 649
organism: Caenorhabditis elegans

EGFR s5 sa8 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.271642349477033
comment: MODIFICATION_RESIDUE_NAME=

uniprot F6ZGX8 644
type: UnificationXref
id: F6ZGX8
db: uniprot

uniprot O44408 323
type: UnificationXref
id: O44408
db: uniprot

P00540
type: UnificationXref
id: P00540
db: PANTHER Pathway Component

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot C8V7D1 228
organism: Emericella nidulans

P00542
type: UnificationXref
id: P00542
db: PANTHER Pathway Component

P00541
type: UnificationXref
id: P00541
db: PANTHER Pathway Component

uniprot E2RR18 1147
type: UnificationXref
id: E2RR18
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q60823 612
organism: Mus musculus

uniprot F1MDC9 1149
type: UnificationXref
id: F1MDC9
db: uniprot

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

SOS
type: Protein
entity reference: SOS
feature: ACTIVE 167
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa15 1244
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

P00539
type: UnificationXref
id: P00539
db: PANTHER Pathway Component

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q5QN75 926
organism: Oryza sativa

uniprot Q39024 260
type: UnificationXref
id: Q39024
db: uniprot

14-3-3 protein eta
type: ProteinReference
xref: uniprot P68511 108
xref: PTHR18860:SF16
organism: Rattus norvegicus

p38
type: Protein
entity reference: p38
feature: ACTIVE 167
feature: p38 s54 a67 rs1
feature: p38 s54 a67 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GAB1 isoform 1
type: ProteinReference
xref: uniprot H2QQ79 1059
xref: PTHR45960:SF5
organism: Pan troglodytes

EGFR s123 a4 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.271642349477033
comment: MODIFICATION_RESIDUE_NAME=

14-3-3-like protein GF14 mu
type: ProteinReference
xref: uniprot Q96299 146
xref: PTHR18860:SF125
organism: Arabidopsis thaliana

uniprot P32254 676
type: UnificationXref
id: P32254
db: uniprot

uniprot Q567Y8 463
type: UnificationXref
id: Q567Y8
db: uniprot

PTHR18860:SF95
type: RelationshipXref
id: PTHR18860:SF95
db: PANTHER Family
relationship type: By Homology

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 398

Pro-neuregulin-2, membrane-bound isoform
type: ProteinReference
xref: uniprot O35569 556
organism: Rattus norvegicus

14-3-3 protein eta
type: ProteinReference
xref: uniprot P68510 107
xref: PTHR18860:SF16
organism: Mus musculus

uniprot F6UA90 642
type: UnificationXref
id: F6UA90
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YCI3 887
xref: PTHR23113:SF150
organism: Monodelphis domestica

MKK3,6 s51 a64 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot A0A3Q1MK31 340
type: UnificationXref
id: A0A3Q1MK31
db: uniprot

E3 ubiquitin-protein ligase CBL-B
type: ProteinReference
xref: PTHR23007:SF3
xref: uniprot Q8K4S7 301
organism: Rattus norvegicus

14-3-3-like protein GF14-B
type: ProteinReference
xref: PTHR18860:SF101
xref: uniprot Q7XTE8 143
organism: Oryza sativa

uniprot P63318 1193
type: UnificationXref
id: P63318
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF20
xref: uniprot P45985 771
organism: Homo sapiens

uniprot Q2TBH2 685
type: UnificationXref
id: Q2TBH2
db: uniprot

uniprot Q9TXI7 878
type: UnificationXref
id: Q9TXI7
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 324
organism: Homo sapiens

DAB2 interacting protein
type: ProteinReference
xref: uniprot H2RC65 355
xref: PTHR10194:SF26
organism: Pan troglodytes

uniprot F7GN93 319
type: UnificationXref
id: F7GN93
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P45984 325
organism: Homo sapiens

GRB2-associated-binding protein 2
type: ProteinReference
xref: PTHR45960:SF1
xref: uniprot Q9UQC2 1069
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform
type: ProteinReference
xref: PTHR10257:SF3
xref: uniprot P78759 448
organism: Schizosaccharomyces pombe

MEK1-2
type: Protein
entity reference: MEK1-2
feature: ACTIVE 167
feature: MEK1 2 s26 a29 rs2
feature: MEK1 2 s26 a29 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q61120 755
type: UnificationXref
id: Q61120
db: uniprot

ncbitaxon 7165 10
type: UnificationXref
id: 7165
db: ncbitaxon

GRB2-associated-binding protein 1
type: ProteinReference
xref: PTHR45960:SF5
xref: uniprot Q13480 1062
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot F6PR50 707
organism: Macaca mulatta

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3RQJ8 1132
type: UnificationXref
id: A0A2I3RQJ8
db: uniprot

MKK3,6 s51 a64 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Mitogen-activated protein kinase HOG1
type: ProteinReference
xref: uniprot P32485 1028
organism: Saccharomyces cerevisiae

PTHR11801:SF39
type: RelationshipXref
id: PTHR11801:SF39
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P14056 956
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7EY67 547
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1272
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1273
left: Akt
interaction type: STATE_TRANSITION
right: Akt

uniprot Q7Q042 1212
type: UnificationXref
id: Q7Q042
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: uniprot F1M7Y5 1148
xref: PTHR24356:SF214
organism: Rattus norvegicus

uniprot F6XP81 602
type: UnificationXref
id: F6XP81
db: uniprot

uniprot P32253 675
type: UnificationXref
id: P32253
db: uniprot

uniprot P10833 670
type: UnificationXref
id: P10833
db: uniprot

GRB2-related adaptor protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot Q4KM68 584
organism: Rattus norvegicus

uniprot P34148 1097
type: UnificationXref
id: P34148
db: uniprot

uniprot P52632 999
type: UnificationXref
id: P52632
db: uniprot

uniprot Q9VDS9 740
type: UnificationXref
id: Q9VDS9
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F7BIC2 1157
organism: Macaca mulatta

Circularly permutated Ras protein 1
type: ProteinReference
xref: uniprot Q75J93 692
organism: Dictyostelium discoideum

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 45

PTHR11801:SF41
type: RelationshipXref
id: PTHR11801:SF41
db: PANTHER Family
relationship type: By Homology

uniprot P24338 562
type: UnificationXref
id: P24338
db: uniprot

PTHR11801:SF47
type: RelationshipXref
id: PTHR11801:SF47
db: PANTHER Family
relationship type: By Homology

MAP kinase kinase MKK1/SSP32
type: ProteinReference
xref: uniprot P32490 915
organism: Saccharomyces cerevisiae

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P05129 1175
xref: PTHR24356:SF162
organism: Homo sapiens

uniprot Q7PPN5 219
type: UnificationXref
id: Q7PPN5
db: uniprot

GTPase HRas
type: ProteinReference
xref: uniprot Q61411 690
xref: PTHR24070:SF385
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r21
controller: Ras

MAP kinase kinase MKK2/SSP33
type: ProteinReference
xref: uniprot P32491 916
organism: Saccharomyces cerevisiae

GTPase NRas
type: ProteinReference
xref: uniprot P08556 664
xref: PTHR24070:SF189
organism: Mus musculus

uniprot Q6GLE6 467
type: UnificationXref
id: Q6GLE6
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05126 1173
organism: Bos taurus

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: uniprot P05128 1174
xref: PTHR24356:SF162
organism: Bos taurus

Heparin binding EGF like growth factor
type: ProteinReference
xref: uniprot E2R275 542
xref: PTHR10740:SF4
organism: Canis lupus familiaris

uniprot A7F3M0 227
type: UnificationXref
id: A7F3M0
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F6QE96 598
organism: Macaca mulatta

TRANSCRIPTION
type: InteractionVocabulary

uniprot K7CDC2 605
type: UnificationXref
id: K7CDC2
db: uniprot

uniprot Q9BZL6 1217
type: UnificationXref
id: Q9BZL6
db: uniprot

uniprot P63000 1102
type: UnificationXref
id: P63000
db: uniprot

Phosphatidylinositol 3-kinase, putative
type: ProteinReference
xref: uniprot Q4GZ26 864
organism: Trypanosoma brucei

uniprot P23561 722
type: UnificationXref
id: P23561
db: uniprot

uniprot F6Z5N3 643
type: UnificationXref
id: F6Z5N3
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F1PRG4 596
organism: Canis lupus familiaris

EGFR s123 a4 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.192356948147228

PTHR18860:SF67
type: RelationshipXref
id: PTHR18860:SF67
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF7
type: RelationshipXref
id: PTHR10048:SF7
db: PANTHER Family
relationship type: By Homology

uniprot F1NLM6 406
type: UnificationXref
id: F1NLM6
db: uniprot

uniprot F0ZI47 636
type: UnificationXref
id: F0ZI47
db: uniprot

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 1183
organism: Mus musculus

uniprot F6TKL3 313
type: UnificationXref
id: F6TKL3
db: uniprot

PTHR11801:SF2
type: RelationshipXref
id: PTHR11801:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q7ZSZ9 1120
type: UnificationXref
id: Q7ZSZ9
db: uniprot

PTHR18860:SF69
type: RelationshipXref
id: PTHR18860:SF69
db: PANTHER Family
relationship type: By Homology

P00565
type: UnificationXref
id: P00565
db: PANTHER Pathway Component

uniprot A0A2I3TRE4 968
type: UnificationXref
id: A0A2I3TRE4
db: uniprot

Sporulation-specific mitogen-activated protein kinase SMK1
type: ProteinReference
xref: uniprot P41808 250
organism: Saccharomyces cerevisiae

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F1N7N8 346
organism: Bos taurus

uniprot F6V332 1018
type: UnificationXref
id: F6V332
db: uniprot

E3 ubiquitin-protein ligase CBL-C
type: ProteinReference
xref: PTHR23007:SF12
xref: uniprot Q80XL1 300
organism: Mus musculus

uniprot F0ZB76 635
type: UnificationXref
id: F0ZB76
db: uniprot

RKIP
type: Protein
entity reference: RKIP
feature: RKIP s30 a33 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF12
xref: uniprot A0A1D5RHD1 149
organism: Macaca mulatta

Mitogen-activated protein kinase 19
type: ProteinReference
xref: uniprot Q9LUC3 281
organism: Arabidopsis thaliana

Protein kinase C, brain isozyme
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P05130 1176
organism: Drosophila melanogaster

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot H2QKD0 786
organism: Pan troglodytes

uniprot F6Y4G1 502
type: UnificationXref
id: F6Y4G1
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot E2RB82 969
organism: Canis lupus familiaris

MAP kinase kinase kinase win1
type: ProteinReference
xref: uniprot O74304 721
organism: Schizosaccharomyces pombe

Mitogen-activated protein kinase spk1
type: ProteinReference
xref: uniprot P27638 245
xref: PTHR24055:SF158
organism: Schizosaccharomyces pombe

RKIP
type: ProteinReference
xref: P00548
standard name: Raf-1 kinase inhibitor protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Raf-1 kinase inhibitor protein Synonym: Hippocampal cholinergic stimulatory peptide precursor,PEBP,Phosphatidylethanolamine-binding protein,Terminal flower 1,neuropolypeptide h3,prostastic binding protein Accession: P00548
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.RKIP
member entity reference: Protein MOTHER of FT and TFL1 homolog 2
member entity reference: Protein TERMINAL FLOWER 1
member entity reference: Phosphatidylethanolamine-binding protein 2
member entity reference: Phosphatidylethanolamine binding protein 4
member entity reference: CEN-like protein 2, putative, expressed
member entity reference: PEBP1 isoform 1
member entity reference: Phosphatidylethanolamine-binding protein 4
member entity reference: AGAP013036-PA
member entity reference: LP12095p
member entity reference: Phosphatidylethanolamine-binding protein 1
member entity reference: Protein CENTRORADIALIS-like
member entity reference: Uncharacterized protein
member entity reference: Phosphatidylethanolamine binding protein
member entity reference: Phosphatidylethanolamine-binding protein homolog F40A3.3
member entity reference: Os01g0748800 protein
member entity reference: Protein CBG05964
member entity reference: AGAP002049-PA
member entity reference: AGAP008909-PA
member entity reference: GH14779p
member entity reference: GH14494p
member entity reference: AGAP012962-PA
member entity reference: Protein HEADING DATE 3A
member entity reference: GH25425p
member entity reference: GH28351p
member entity reference: Lipid binding protein
member entity reference: Protein TWIN SISTER of FT
member entity reference: Putative odorant-binding protein A5
member entity reference: Protein RICE FLOWERING LOCUS T 1
member entity reference: IP07080p
member entity reference: CENTRORADIALIS, putative, expressed
member entity reference: Protein FLOWERING LOCUS T

Protein kinase C-like 2
type: ProteinReference
xref: uniprot P36583 1191
xref: PTHR24356:SF390
organism: Schizosaccharomyces pombe

uniprot A0A1D5QAU9 761
type: UnificationXref
id: A0A1D5QAU9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot A8WRD7 1013
organism: Caenorhabditis briggsae

Protein kinase C-like 1
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P36582 1190
organism: Schizosaccharomyces pombe

uniprot Q9LV37 282
type: UnificationXref
id: Q9LV37
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P10398 952
organism: Homo sapiens

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F0ZDJ1 402
xref: PTHR45619:SF12
organism: Dictyostelium purpureum

STATE_TRANSITION_LEFT__EGFR-RIGHT__a87_degraded-_r59
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1284
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 1285
left: EGFR
interaction type: STATE_TRANSITION
right: a87_degraded

uniprot P45984 325
type: UnificationXref
id: P45984
db: uniprot

P00552
type: UnificationXref
id: P00552
db: PANTHER Pathway Component

P00553
type: UnificationXref
id: P00553
db: PANTHER Pathway Component

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot Q5E9X2 164
xref: PTHR44305:SF4
organism: Bos taurus

P00550
type: UnificationXref
id: P00550
db: PANTHER Pathway Component

MKK4,7
type: Protein
entity reference: MKK4,7
feature: MKK4,7 s39 a41 rs2
feature: MKK4,7 s39 a41 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3S5ZPJ0 381
type: UnificationXref
id: A0A3S5ZPJ0
db: uniprot

P00551
type: UnificationXref
id: P00551
db: PANTHER Pathway Component

uniprot P63101 100
type: UnificationXref
id: P63101
db: uniprot

uniprot P47197 610
type: UnificationXref
id: P47197
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot O88763 849
xref: PTHR10048:SF7
organism: Rattus norvegicus

Signal transducer and activator of transcription 2
type: ProteinReference
xref: uniprot P52630 997
organism: Homo sapiens

RAS protein activator like 2
type: ProteinReference
xref: PTHR10194:SF52
xref: uniprot A0A3Q1M8V3 339
organism: Bos taurus

uniprot Q54TK8 899
type: UnificationXref
id: Q54TK8
db: uniprot

EGFR s123 a4 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.8660799645249737

PTHR18860:SF83
type: RelationshipXref
id: PTHR18860:SF83
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q7ZUS7 477
organism: Danio rerio

uniprot Q04690 362
type: UnificationXref
id: Q04690
db: uniprot

uniprot Q5SN53 267
type: UnificationXref
id: Q5SN53
db: uniprot

P00546
type: UnificationXref
id: P00546
db: PANTHER Pathway Component

P00545
type: UnificationXref
id: P00545
db: PANTHER Pathway Component

uniprot O61443 1026
type: UnificationXref
id: O61443
db: uniprot

P00544
type: UnificationXref
id: P00544
db: PANTHER Pathway Component

ncbitaxon 185431 257
type: UnificationXref
id: 185431
db: ncbitaxon

P00543
type: UnificationXref
id: P00543
db: PANTHER Pathway Component

P00549
type: UnificationXref
id: P00549
db: PANTHER Pathway Component

P00548
type: UnificationXref
id: P00548
db: PANTHER Pathway Component

P00547
type: UnificationXref
id: P00547
db: PANTHER Pathway Component

uniprot A0A1D5RL09 378
type: UnificationXref
id: A0A1D5RL09
db: uniprot

E3 ubiquitin-protein ligase CBL-C
type: ProteinReference
xref: PTHR23007:SF12
xref: uniprot Q9ULV8 302
organism: Homo sapiens

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot K7CDC2 605
xref: PTHR24356:SF176
organism: Pan troglodytes

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot Q6DV79 1005
organism: Gallus gallus

P00560
type: UnificationXref
id: P00560
db: PANTHER Pathway Component

Cell division control protein 25
type: ProteinReference
xref: uniprot Q7RYH5 902
organism: Neurospora crassa

P00561
type: UnificationXref
id: P00561
db: PANTHER Pathway Component

P00562
type: UnificationXref
id: P00562
db: PANTHER Pathway Component

uniprot F6XW91 50
type: UnificationXref
id: F6XW91
db: uniprot

P00563
type: UnificationXref
id: P00563
db: PANTHER Pathway Component

P00564
type: UnificationXref
id: P00564
db: PANTHER Pathway Component

Signal transducer and activator of transcription 3
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot P52631 998
organism: Rattus norvegicus

EGFR
type: Protein
entity reference: EGFR
feature: EGFR s5 sa8 rs3
feature: EGFR s5 sa8 rs2
feature: ACTIVE 167
feature: EGFR s5 sa8 rs1
feature: EGFR s5 sa8 rs4

PTHR24055:SF238
type: RelationshipXref
id: PTHR24055:SF238
db: PANTHER Family
relationship type: By Homology

Signal transducer and activator of transcription 5B
type: ProteinReference
xref: uniprot P52632 999
xref: PTHR11801:SF39
organism: Rattus norvegicus

uniprot P07522 560
type: UnificationXref
id: P07522
db: uniprot

Signal transducer and transcription activator 6
type: ProteinReference
xref: PTHR11801:SF48
xref: uniprot P52633 1000
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot E9H8M4 34
xref: PTHR18860:SF17
organism: Daphnia pulex

PTHR18860:SF72
type: RelationshipXref
id: PTHR18860:SF72
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot E2QU83 1080
organism: Canis lupus familiaris

3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
type: ProteinReference
xref: uniprot E7F354 30
xref: PTHR18860:SF22
organism: Danio rerio

P00555
type: UnificationXref
id: P00555
db: PANTHER Pathway Component

uniprot H2Q8F2 1165
type: UnificationXref
id: H2Q8F2
db: uniprot

P00554
type: UnificationXref
id: P00554
db: PANTHER Pathway Component

Mitogen-activated protein kinase SLT2/MPK1
type: ProteinReference
xref: uniprot Q00772 253
organism: Saccharomyces cerevisiae

uniprot F7HSM1 423
type: UnificationXref
id: F7HSM1
db: uniprot

P00557
type: UnificationXref
id: P00557
db: PANTHER Pathway Component

P00556
type: UnificationXref
id: P00556
db: PANTHER Pathway Component

P00559
type: UnificationXref
id: P00559
db: PANTHER Pathway Component

P00558
type: UnificationXref
id: P00558
db: PANTHER Pathway Component

uniprot Q03206 1104
type: UnificationXref
id: Q03206
db: uniprot

EGFR s123 a4 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.29874869898594847
comment: MODIFICATION_RESIDUE_NAME=

Neurofibromin 1, isoform B
type: ProteinReference
xref: PTHR10194:SF60
xref: uniprot Q9VBJ2 372
organism: Drosophila melanogaster

uniprot O62618 1027
type: UnificationXref
id: O62618
db: uniprot

uniprot H2RA86 240
type: UnificationXref
id: H2RA86
db: uniprot

PTHR18860:SF21
type: RelationshipXref
id: PTHR18860:SF21
db: PANTHER Family
relationship type: By Homology

uniprot C8V7D1 228
type: UnificationXref
id: C8V7D1
db: uniprot

PTHR18860:SF22
type: RelationshipXref
id: PTHR18860:SF22
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A0H3 53
xref: PTHR18860:SF3
organism: Ornithorhynchus anatinus

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F7BYN4 979
organism: Monodelphis domestica

Ras guanine nucleotide exchange factor B
type: ProteinReference
xref: uniprot Q8IS21 904
organism: Dictyostelium discoideum

uniprot H2QKD0 786
type: UnificationXref
id: H2QKD0
db: uniprot

uniprot A2VE27 540
type: UnificationXref
id: A2VE27
db: uniprot

uniprot Q9TYT3 759
type: UnificationXref
id: Q9TYT3
db: uniprot

uniprot A0A2I3RZ31 306
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

uniprot Q8LF36 482
type: UnificationXref
id: Q8LF36
db: uniprot

uniprot Q21029 729
type: UnificationXref
id: Q21029
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot Q7ZUQ2 476
organism: Danio rerio

Ras guanine nucleotide exchange factor A
type: ProteinReference
xref: uniprot Q54PQ4 898
organism: Dictyostelium discoideum

uniprot P22543 850
type: UnificationXref
id: P22543
db: uniprot

SOS s136 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Protein sprouty homolog 4
type: DnaReference
xref: PTHR12365:SF6
organism: Mus musculus

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1N7C3 882
xref: PTHR23113:SF168
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63085 251
xref: PTHR24055:SF203
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: uniprot F1MDC9 1149
xref: PTHR24351:SF182
organism: Bos taurus

uniprot P15064 671
type: UnificationXref
id: P15064
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63086 252
xref: PTHR24055:SF203
organism: Rattus norvegicus

uniprot Q9SSX0 1127
type: UnificationXref
id: Q9SSX0
db: uniprot

PTHR24416:SF137
type: RelationshipXref
id: PTHR24416:SF137
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF28
type: RelationshipXref
id: PTHR18860:SF28
db: PANTHER Family
relationship type: By Homology

uniprot H2QT14 427
type: UnificationXref
id: H2QT14
db: uniprot

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 167
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P32345 437
type: UnificationXref
id: P32345
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot P53778 1030
organism: Homo sapiens

SOS s14 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZMG8 1111
organism: Gallus gallus

PTHR18860:SF16
type: RelationshipXref
id: PTHR18860:SF16
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P53779 328
xref: PTHR24055:SF162
organism: Homo sapiens

PTHR18860:SF14
type: RelationshipXref
id: PTHR18860:SF14
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1262
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1261
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1263
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1260
left: Ras
left: GDP
interaction type: STATE_TRANSITION
right: Ras
right: GTP

PARTICIPANT STOICHIOMETRY r7 1272
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 1273
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot F6XFG9 48
xref: PTHR18860:SF28
organism: Macaca mulatta

uniprot A8XPY6 580
type: UnificationXref
id: A8XPY6
db: uniprot

uniprot V5ILY0 934
type: UnificationXref
id: V5ILY0
db: uniprot

ncbitaxon 237561 69
type: UnificationXref
id: 237561
db: ncbitaxon

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: PTHR24361:SF342
xref: uniprot F1MSX4 703
organism: Bos taurus

PTHR18860:SF17
type: RelationshipXref
id: PTHR18860:SF17
db: PANTHER Family
relationship type: By Homology

Rac family small GTPase 1
type: ProteinReference
xref: uniprot Q6GL60 1114
xref: PTHR24072:SF105
organism: Xenopus tropicalis

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: uniprot F6XMN6 1154
xref: PTHR24356:SF170
organism: Canis lupus familiaris

uniprot O42376 1025
type: UnificationXref
id: O42376
db: uniprot

PTHR10048:SF109
type: RelationshipXref
id: PTHR10048:SF109
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
evidence: Evidence 939
evidence: Evidence 936
evidence: Evidence 937
evidence: Evidence 938
xref: PTHR44329:SF22
xref: uniprot F7BRK5 946
organism: Monodelphis domestica

Uncharacterized protein rac1A
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot F1A084 1083
organism: Dictyostelium purpureum

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q02750 920
organism: Homo sapiens

uniprot P01135 559
type: UnificationXref
id: P01135
db: uniprot

uniprot P34149 1098
type: UnificationXref
id: P34149
db: uniprot

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q62245 901
xref: PTHR23113:SF168
organism: Mus musculus

PTHR45960:SF3
type: RelationshipXref
id: PTHR45960:SF3
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 1277
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 1276
left: PKC
interaction type: STATE_TRANSITION
right: PKC

uniprot F1A084 1083
type: UnificationXref
id: F1A084
db: uniprot

PTHR45960:SF5
type: RelationshipXref
id: PTHR45960:SF5
db: PANTHER Family
relationship type: By Homology

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot A0A2R8Q8S1 620
organism: Danio rerio

MODULATION
type: TemplateReactionRegulation
xref: MODULATION
controlled: TRANSCRIPTION_LEFT__SPRY-RIGHT__SPRY-_re29
controller: EGFR

PTHR45960:SF1
type: RelationshipXref
id: PTHR45960:SF1
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LWJ8 307
organism: Bos taurus

PTHR24070:SF17
type: RelationshipXref
id: PTHR24070:SF17
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r4 1283
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Ras
type: Protein
entity reference: Ras
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein sprouty homolog 2
type: ProteinReference
xref: PTHR12365:SF8
xref: uniprot Q9QXV8 191
organism: Mus musculus

uniprot P31750 607
type: UnificationXref
id: P31750
db: uniprot

PARTICIPANT STOICHIOMETRY r4 1282
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot P05128 1174
type: UnificationXref
id: P05128
db: uniprot

Raf-1
type: ProteinReference
xref: P00560
standard name: RAF proto-oncogene serine/threonine-protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: RAF proto-oncogene serine/threonine-protein kinase Synonym: C-Raf,MAP kinase kinase kinase,Raf-1 Accession: P00560
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Raf_minus_1
member entity reference: A-Raf proto-oncogene, serine/threonine kinase
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: Raf homolog serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase B-raf
member entity reference: Raf homolog serine/threonine-protein kinase Raf
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: B-Raf proto-oncogene, serine/threonine kinase
member entity reference: Uncharacterized protein

Protein sprouty homolog 1
type: ProteinReference
xref: PTHR12365:SF10
xref: uniprot Q9QXV9 192
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r4 1281
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot A0A2I3TNY5 966
xref: PTHR11801:SF18
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r4 1280
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Growth factor receptor-bound protein 2
type: ProteinReference
evidence: Evidence 588
xref: PTHR46037:SF4
xref: uniprot Q6PC73 587
organism: Danio rerio

uniprot A0A1D5R8E9 777
type: UnificationXref
id: A0A1D5R8E9
db: uniprot

uniprot P36005 248
type: UnificationXref
id: P36005
db: uniprot

PKC
type: Protein
entity reference: PKC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F7BQ11 978
type: UnificationXref
id: F7BQ11
db: uniprot

uniprot A0A1D5QUZ8 224
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

PTHR18860:SF31
type: RelationshipXref
id: PTHR18860:SF31
db: PANTHER Family
relationship type: By Homology

uniprot O43597 183
type: UnificationXref
id: O43597
db: uniprot

uniprot Q5PU49 1207
type: UnificationXref
id: Q5PU49
db: uniprot

uniprot Q9Y2U5 741
type: UnificationXref
id: Q9Y2U5
db: uniprot

uniprot A5D7R9 623
type: UnificationXref
id: A5D7R9
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q05655 1202
xref: PTHR24356:SF365
organism: Homo sapiens

uniprot P19174 790
type: UnificationXref
id: P19174
db: uniprot

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 33

MAP2K4 isoform 3
type: ProteinReference
xref: PTHR48013:SF20
xref: uniprot H2QCA7 768
organism: Pan troglodytes

14-3-3 protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot Q6P4Z5 135
organism: Xenopus tropicalis

uniprot F1M182 543
type: UnificationXref
id: F1M182
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F1PBL1 35
organism: Canis lupus familiaris

uniprot Q15172 458
type: UnificationXref
id: Q15172
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot Q61194 867
organism: Mus musculus

uniprot A0A0R4IKK9 304
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

uniprot Q62925 734
type: UnificationXref
id: Q62925
db: uniprot

uniprot F1NYZ2 908
type: UnificationXref
id: F1NYZ2
db: uniprot

Ras guanine nucleotide exchange factor E
type: ProteinReference
xref: uniprot Q8IS18 903
organism: Dictyostelium discoideum

RKIP s29 a32 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot A8KBH6 1136
type: UnificationXref
id: A8KBH6
db: uniprot

uniprot Q9ULV8 302
type: UnificationXref
id: Q9ULV8
db: uniprot

MAP kinase kinase kinase
type: ProteinReference
xref: uniprot Q1K904 728
organism: Neurospora crassa

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 167
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot O14944 554
type: UnificationXref
id: O14944
db: uniprot

GTPase HRas isoform 1
type: ProteinReference
xref: uniprot F7F5K9 646
xref: PTHR24070:SF385
organism: Macaca mulatta

uniprot Q16537 460
type: UnificationXref
id: Q16537
db: uniprot

uniprot E2QWU5 632
type: UnificationXref
id: E2QWU5
db: uniprot

Rho-related protein racF2
type: ProteinReference
xref: uniprot Q9GPS3 1126
organism: Dictyostelium discoideum

Grb2 s2 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F7C5Z9 417
xref: PTHR10257:SF89
organism: Monodelphis domestica

uniprot P15056 957
type: UnificationXref
id: P15056
db: uniprot

uniprot F1MXH6 704
type: UnificationXref
id: F1MXH6
db: uniprot

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: uniprot Q17941 611
xref: PTHR24356:SF333
organism: Caenorhabditis elegans

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot F4HRJ4 706
organism: Arabidopsis thaliana

Rho-related protein racG
type: ProteinReference
xref: uniprot Q9GPS0 1125
organism: Dictyostelium discoideum

uniprot O35181 555
type: UnificationXref
id: O35181
db: uniprot

Grb2
type: ProteinReference
xref: P00550
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Grb2
comment: ENTITY_REFERENCE_NOTES=Long Name: Grb2 Synonym: sem-5 Accession: P00550
member entity reference: Growth factor receptor-bound protein 2
member entity reference: GRB2-related adapter protein
member entity reference: Protein enhancer of sevenless 2B
member entity reference: GRB2-related adaptor protein
member entity reference: Protein CBR-SEM-5
member entity reference: Growth factor receptor-bound protein 2a
member entity reference: Sex muscle abnormal protein 5

uniprot P05130 1176
type: UnificationXref
id: P05130
db: uniprot

uniprot P10301 669
type: UnificationXref
id: P10301
db: uniprot

uniprot Q1HG70 923
type: UnificationXref
id: Q1HG70
db: uniprot

uniprot F7G6M6 178
type: UnificationXref
id: F7G6M6
db: uniprot

uniprot E1BE66 812
type: UnificationXref
id: E1BE66
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F1PS03 782
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase PP2A-3 catalytic subunit
type: ProteinReference
xref: uniprot Q07100 450
organism: Arabidopsis thaliana

PTHR11801:SF48
type: RelationshipXref
id: PTHR11801:SF48
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q9FZ36 739
organism: Arabidopsis thaliana

PTHR24072:SF13
type: RelationshipXref
id: PTHR24072:SF13
db: PANTHER Family
relationship type: By Homology

uniprot Q8VIN1 521
type: UnificationXref
id: Q8VIN1
db: uniprot

AGAP002729-PA
type: ProteinReference
xref: uniprot Q7QCN5 367
xref: PTHR10194:SF19
organism: Anopheles gambiae

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A0G2K344 797
organism: Rattus norvegicus

uniprot Q00772 253
type: UnificationXref
id: Q00772
db: uniprot

uniprot P04412 207
type: UnificationXref
id: P04412
db: uniprot

uniprot Q5ZMT0 133
type: UnificationXref
id: Q5ZMT0
db: uniprot

uniprot F6YZJ5 1057
type: UnificationXref
id: F6YZJ5
db: uniprot

Mitogen-activated protein kinase 18
type: ProteinReference
xref: uniprot Q9C5C0 277
organism: Arabidopsis thaliana

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot A8KBH6 1136
organism: Xenopus tropicalis

V-akt murine thymoma viral oncogene homolog 2,-like
type: ProteinReference
xref: uniprot A0A0R4IY09 589
organism: Danio rerio

Uncharacterized protein rasB
type: ProteinReference
xref: uniprot F0ZI47 636
xref: PTHR24070:SF206
organism: Dictyostelium purpureum

uniprot P62999 1101
type: UnificationXref
id: P62999
db: uniprot

uniprot H2R5K3 714
type: UnificationXref
id: H2R5K3
db: uniprot

uniprot P52633 1000
type: UnificationXref
id: P52633
db: uniprot

Phosphoinositide 3-kinase regulatory subunit 5
type: ProteinReference
xref: uniprot Q5ZIB8 866
organism: Gallus gallus

uniprot P61982 94
type: UnificationXref
id: P61982
db: uniprot

Signal transducer and activator of transcription 5A
type: ProteinReference
xref: uniprot Q95115 1008
xref: PTHR11801:SF47
organism: Bos taurus

uniprot P29353 750
type: UnificationXref
id: P29353
db: uniprot

uniprot P54674 859
type: UnificationXref
id: P54674
db: uniprot

Uncharacterized protein rasG
type: ProteinReference
xref: uniprot F0ZWE6 638
xref: PTHR24070:SF17
organism: Dictyostelium purpureum

PTHR22968:SF9
type: RelationshipXref
id: PTHR22968:SF9
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F1Q3M8 820
organism: Canis lupus familiaris

uniprot A0A1D5QPR1 963
type: UnificationXref
id: A0A1D5QPR1
db: uniprot

uniprot P14056 956
type: UnificationXref
id: P14056
db: uniprot

uniprot P16885 789
type: UnificationXref
id: P16885
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q5ZIF0 927
organism: Gallus gallus

uniprot E9H8M4 34
type: UnificationXref
id: E9H8M4
db: uniprot

uniprot Q86H88 520
type: UnificationXref
id: Q86H88
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot C3XQF4 397
xref: PTHR45619:SF12
organism: Branchiostoma floridae

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot H9FVU5 841
organism: Macaca mulatta

uniprot O09110 160
type: UnificationXref
id: O09110
db: uniprot

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36507 918
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36506 917
organism: Rattus norvegicus

EGFR s5 sa8 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.192356948147228

RAS related 2
type: ProteinReference
xref: uniprot K7DK66 655
organism: Pan troglodytes

Spry
type: ProteinReference
xref: P00541
standard name: sprouty
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: sprouty Synonym: antagonist of FGF signaling Accession: P00541
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Spry
member entity reference: Protein sprouty homolog 1
member entity reference: Protein sprouty homolog 3
member entity reference: Sprouty RTK signaling antagonist 3
member entity reference: Protein sprouty homolog 4
member entity reference: SPRY1 isoform 1
member entity reference: Sprouty RTK signaling antagonist 4
member entity reference: Sprouty RTK signaling antagonist 2
member entity reference: Sprouty RTK-signaling antagonist 2
member entity reference: Sprouty homolog 4 (Drosophila)
member entity reference: Protein sprouty
member entity reference: RCG49355
member entity reference: Uncharacterized protein
member entity reference: Protein sprouty homolog 2
member entity reference: RCG41526, isoform CRA_a

uniprot A0A0D1E7J2 3
type: UnificationXref
id: A0A0D1E7J2
db: uniprot

14-3-3 protein gamma-1
type: ProteinReference
xref: uniprot Q6PC29 136
xref: PTHR18860:SF22
organism: Danio rerio

Protein kinase C
type: ProteinReference
xref: uniprot Q7QCP8 1213
xref: PTHR24356:SF240
organism: Anopheles gambiae

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7BYI4 1158
organism: Macaca mulatta

14-3-3
type: ProteinReference
xref: P00539
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.14_minus_3_minus_3
comment: ENTITY_REFERENCE_NOTES=Long Name: 14-3-3 Synonym: PAR-5,Stratifin,protein kinase C inhibitor protein-1 (KCIP-1) Accession: P00539
member entity reference: 14-3-3 protein gamma
member entity reference: 14-3-3 protein
member entity reference: Uncharacterized protein
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1
member entity reference: 14-3-3 protein homolog
member entity reference: 14-3-3-like protein GF14 mu
member entity reference: 14-3-3 protein 3
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
member entity reference: 14-3-3 protein epsilon
member entity reference: 14-3-3-like protein GF14-E
member entity reference: 14-3-3 protein sigma
member entity reference: 14-3-3 protein, putative
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
member entity reference: Similar to 14-3-3 protein sigma
member entity reference: 14-3-3 protein zeta/delta
member entity reference: Protein BMH1
member entity reference: SFN isoform 1
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
member entity reference: Multifunctional chaperone, putative
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
member entity reference: AGR107Cp
member entity reference: Protein CBR-PAR-5
member entity reference: General regulatory factor 13
member entity reference: 14-3-3-like protein GF14 omicron
member entity reference: 14-3-3-like protein GF14 kappa
member entity reference: 14-3-3-like protein GF14-G
member entity reference: 14-3-3 protein beta/alpha
member entity reference: 14-3-3 protein theta
member entity reference: 14-3-3-like protein GF14 lambda
member entity reference: 14-3-3-like protein GF14 epsilon
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
member entity reference: 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
member entity reference: 14-3-3 protein 2
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
member entity reference: 14-3-3 family protein 7
member entity reference: 14-3-3-like protein 2
member entity reference: 14-3-3 protein gamma-1
member entity reference: 14-3-3-like protein GF14 omega
member entity reference: 14-3-3 zeta
member entity reference: Protein BMH2
member entity reference: 14-3-3 protein eta
member entity reference: 14-3-3 protein zeta
member entity reference: 14-3-3 family protein
member entity reference: 14-3-3-like protein 1
member entity reference: 14-3-3-like protein GF14-C
member entity reference: 14-3-3 protein 1
member entity reference: 14-3-3-like protein GF14-F

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase 20
type: ProteinReference
xref: uniprot Q9SJG9 283
organism: Arabidopsis thaliana

ncbitaxon 559292 77
type: UnificationXref
id: 559292
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR10740:SF12
xref: uniprot F7D8W9 546
organism: Macaca mulatta

sprouty
type: DnaRegionReference
member entity reference: Sprouty RTK signaling antagonist 4
member entity reference: Sprouty RTK-signaling antagonist 2
member entity reference: Protein sprouty homolog 2
member entity reference: Sprouty RTK signaling antagonist 3
member entity reference: Protein sprouty homolog 1
member entity reference: SPRY1 isoform 1
member entity reference: Protein sprouty homolog 4
member entity reference: Uncharacterized protein
member entity reference: Protein sprouty homolog 3
member entity reference: RCG49355
member entity reference: Sprouty homolog 4 (Drosophila)
member entity reference: RCG41526, isoform CRA_a
member entity reference: Sprouty RTK signaling antagonist 2
member entity reference: Protein sprouty
xref: G01511
comment: ENTITY_REFERENCE_NOTES=Long Name: SPRY Synonym: antagonist of FGF signaling Accession: G01511
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.GENE.GENE.SPRY
display name: SPRY

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot H2Q8X8 425
xref: PTHR10257:SF19
organism: Pan troglodytes

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot O35099 720
xref: PTHR11584:SF332
organism: Mus musculus

uniprot Q9SXZ2 529
type: UnificationXref
id: Q9SXZ2
db: uniprot

uniprot F7BYT3 503
type: UnificationXref
id: F7BYT3
db: uniprot

uniprot Q1K771 513
type: UnificationXref
id: Q1K771
db: uniprot

ncbitaxon 284812 246
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot P67775 447
type: UnificationXref
id: P67775
db: uniprot

uniprot P41932 83
type: UnificationXref
id: P41932
db: uniprot

uniprot Q86SQ0 1063
type: UnificationXref
id: Q86SQ0
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot F6Y841 829
xref: PTHR10048:SF33
organism: Canis lupus familiaris

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 807
organism: Rattus norvegicus

Protein sprouty homolog 2
type: DnaReference
xref: PTHR12365:SF8
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6WA79 47
xref: PTHR18860:SF16
organism: Monodelphis domestica

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 120

Protein sprouty homolog 1
type: DnaReference
xref: PTHR12365:SF10
organism: Mus musculus

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

uniprot H2R0G7 322
type: UnificationXref
id: H2R0G7
db: uniprot

EGFR s5 sa8 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=0.29874869898594847
comment: MODIFICATION_RESIDUE_NAME=

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P62999 1101
xref: PTHR24072:SF105
organism: Canis lupus familiaris

Pro-epidermal growth factor
type: ProteinReference
xref: uniprot F7B762 544
organism: Equus caballus

14-3-3 protein gamma
type: ProteinReference
xref: uniprot F6XLR8 49
xref: PTHR18860:SF22
organism: Macaca mulatta

uniprot F7EJU0 158
type: UnificationXref
id: F7EJU0
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF4
xref: uniprot H2Q411 424
organism: Pan troglodytes

MEK1-2
type: Protein
entity reference: MEK1-2
feature: MEK1 2 s25 a28 rs2
feature: MEK1 2 s25 a28 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein sprouty
type: DnaReference
xref: PTHR12365:SF7
organism: Drosophila melanogaster

uniprot F0ZVH9 637
type: UnificationXref
id: F0ZVH9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UA90 642
organism: Xenopus tropicalis

Ras homolog family member Q
type: ProteinReference
xref: uniprot Q7ZVI3 1121
xref: PTHR24072:SF13
organism: Danio rerio

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q4QHG6 263
organism: Leishmania major

uniprot P36582 1190
type: UnificationXref
id: P36582
db: uniprot

Signal transducer and activator of transcription 1
type: ProteinReference
xref: uniprot Q9NAD6 1009
organism: Caenorhabditis elegans

uniprot Q7QK91 693
type: UnificationXref
id: Q7QK91
db: uniprot

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63103 102
organism: Bos taurus

Serine/threonine-protein kinase SSK22
type: ProteinReference
xref: uniprot P25390 723
organism: Saccharomyces cerevisiae

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63104 103
organism: Homo sapiens

Akt
type: ProteinReference
xref: P00551
standard name: protein kinase B
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Akt
comment: ENTITY_REFERENCE_NOTES=Long Name: Thymoma viral proto-oncogene Synonym: PKB,RAC protein kinase,protein kinase B Accession: P00551
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: V-akt murine thymoma viral oncogene homolog 2,-like
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-1
member entity reference: Serine/threonine-protein kinase akt-2
member entity reference: RAC serine/threonine-protein kinase

uniprot A8XSS4 628
type: UnificationXref
id: A8XSS4
db: uniprot

Uncharacterized protein rasS
type: ProteinReference
xref: PTHR24070:SF380
xref: uniprot F0ZVH9 637
organism: Dictyostelium purpureum

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6SW23 822
organism: Gallus gallus

uniprot A0A3Q1M864 1052
type: UnificationXref
id: A0A3Q1M864
db: uniprot

uniprot E1B847 700
type: UnificationXref
id: E1B847
db: uniprot

Neurofibromin
type: ProteinReference
xref: PTHR10194:SF60
xref: uniprot P97526 361
organism: Rattus norvegicus

uniprot Q19243 255
type: UnificationXref
id: Q19243
db: uniprot

uniprot P51692 996
type: UnificationXref
id: P51692
db: uniprot

uniprot P62714 441
type: UnificationXref
id: P62714
db: uniprot

Phosphatidylinositol 3-kinase vps34
type: ProteinReference
xref: uniprot P50520 857
xref: PTHR10048:SF7
organism: Schizosaccharomyces pombe

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F7BQ11 978
xref: PTHR11801:SF39
organism: Gallus gallus

uniprot P04049 948
type: UnificationXref
id: P04049
db: uniprot

uniprot D4A229 1138
type: UnificationXref
id: D4A229
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A3Q1MMD9 779
organism: Bos taurus

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63102 101
organism: Rattus norvegicus

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q9WUI1 1045
organism: Mus musculus

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63101 100
organism: Mus musculus

Proepiregulin
type: ProteinReference
xref: uniprot Q9Z0L5 579
organism: Rattus norvegicus

uniprot Q8BZ03 1214
type: UnificationXref
id: Q8BZ03
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot Q9Y6R4 742
organism: Homo sapiens

uniprot Q5TZD5 1109
type: UnificationXref
id: Q5TZD5
db: uniprot

Receptor tyrosine-protein kinase erbB-2
type: ProteinReference
xref: PTHR24416:SF137
xref: uniprot P70424 212
organism: Mus musculus

GRB2-associated-binding protein 3
type: ProteinReference
xref: uniprot Q8BSM5 1064
xref: PTHR45960:SF3
organism: Mus musculus

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q5M824 754
xref: PTHR10337:SF2
organism: Rattus norvegicus

uniprot Q07889 894
type: UnificationXref
id: Q07889
db: uniprot

Phosphoinositide phospholipase C (Fragment)
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot F1QLX2 783
organism: Danio rerio

Mitogen-activated protein kinase p38a
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot O62618 1027
organism: Drosophila melanogaster

uniprot F7FDA0 833
type: UnificationXref
id: F7FDA0
db: uniprot

uniprot A0A0G2K5T3 798
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

uniprot Q7ZVK8 274
type: UnificationXref
id: Q7ZVK8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 274
organism: Danio rerio

14-3-3 protein theta
type: ProteinReference
xref: uniprot P68255 106
xref: PTHR18860:SF3
organism: Rattus norvegicus

uniprot P48580 440
type: UnificationXref
id: P48580
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 77

14-3-3 protein theta
type: ProteinReference
xref: uniprot P68254 105
xref: PTHR18860:SF3
organism: Mus musculus

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F6URW3 886
xref: PTHR23113:SF150
organism: Ornithorhynchus anatinus

Well-rounded, isoform B
type: ProteinReference
xref: uniprot Q8IN89 481
organism: Drosophila melanogaster

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 75

Ras GTPase-activating protein 4
type: ProteinReference
xref: uniprot O43374 356
xref: PTHR10194:SF4
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
type: ProteinReference
xref: uniprot Q22070 793
organism: Caenorhabditis elegans

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
type: ProteinReference
xref: uniprot F1PKW7 36
xref: PTHR18860:SF28
organism: Canis lupus familiaris

uniprot Q9WTY9 1044
type: UnificationXref
id: Q9WTY9
db: uniprot

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot P68250 104
xref: PTHR18860:SF28
organism: Bos taurus

uniprot D4A3T0 880
type: UnificationXref
id: D4A3T0
db: uniprot

Lipid binding protein
type: ProteinReference
xref: uniprot Q1K771 513
organism: Neurospora crassa

Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
type: ProteinReference
xref: uniprot Q0DBD3 452
organism: Oryza sativa

Ras-related protein R-Ras2
type: ProteinReference
xref: uniprot P62071 678
organism: Mus musculus

Ras-related protein R-Ras2
type: ProteinReference
xref: uniprot P62070 677
organism: Homo sapiens

14-3-3 protein sigma
type: ProteinReference
xref: uniprot G7MHX1 62
xref: PTHR18860:SF14
organism: Macaca mulatta

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
type: ProteinReference
xref: uniprot P38903 438
organism: Saccharomyces cerevisiae

uniprot Q5XIS9 1208
type: UnificationXref
id: Q5XIS9
db: uniprot

Ras GTPase-activating protein 1
type: ProteinReference
xref: uniprot P50904 360
xref: PTHR10194:SF19
organism: Rattus norvegicus

uniprot P42224 988
type: UnificationXref
id: P42224
db: uniprot

Mitogen-activated protein kinase KSS1
type: ProteinReference
xref: uniprot P14681 241
organism: Saccharomyces cerevisiae

uniprot O43610 185
type: UnificationXref
id: O43610
db: uniprot

uniprot E2RL20 945
type: UnificationXref
id: E2RL20
db: uniprot

PTHR24361:SF656
type: RelationshipXref
id: PTHR24361:SF656
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A1D5PXC6 305
organism: Gallus gallus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot Q7TNL5 475
organism: Mus musculus

STATE_TRANSITION_LEFT__ERK1_2-RIGHT__ERK1_2-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 1275
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 1274
left: ERK1-2
interaction type: STATE_TRANSITION
right: ERK1-2

uniprot A0A1D5QE27 799
type: UnificationXref
id: A0A1D5QE27
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8X1S0 310
organism: Caenorhabditis briggsae

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 22

uniprot B5DF98 699
type: UnificationXref
id: B5DF98
db: uniprot

Pleckstrin homology-like domain family B member 2
type: ProteinReference
xref: uniprot Q86SQ0 1063
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot E2RQM0 781
organism: Canis lupus familiaris

uniprot Q95ME4 694
type: UnificationXref
id: Q95ME4
db: uniprot

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot P53349 724
organism: Mus musculus

Putative mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q4QHJ8 264
organism: Leishmania major

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF21
xref: uniprot A0A1D5QAB6 337
organism: Macaca mulatta

uniprot H2Q8X8 425
type: UnificationXref
id: H2Q8X8
db: uniprot

ncbitaxon 9796 545
type: UnificationXref
id: 9796
db: ncbitaxon

uniprot Q02750 920
type: UnificationXref
id: Q02750
db: uniprot

uniprot P63102 101
type: UnificationXref
id: P63102
db: uniprot

uniprot P20444 1183
type: UnificationXref
id: P20444
db: uniprot

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q66JE6 929
organism: Xenopus tropicalis

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 270
organism: Danio rerio

uniprot F6Z879 766
type: UnificationXref
id: F6Z879
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: uniprot P29353 750
xref: PTHR10337:SF2
organism: Homo sapiens

Sex muscle abnormal protein 5
type: ProteinReference
xref: uniprot P29355 581
xref: PTHR46037:SF1
organism: Caenorhabditis elegans

Amphiregulin
type: ProteinReference
xref: PTHR10740:SF12
xref: uniprot P24338 562
organism: Rattus norvegicus

uniprot O14807 657
type: UnificationXref
id: O14807
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1P630 311
organism: Canis lupus familiaris

Phosphoinositide-3-kinase, regulatory subunit 6
type: ProteinReference
xref: uniprot F1LNJ8 817
organism: Rattus norvegicus

Protein kinase C eta type
type: ProteinReference
xref: uniprot P23298 1184
xref: PTHR24356:SF192
organism: Mus musculus

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot A0A2I3TQ88 967
organism: Pan troglodytes

uniprot P35213 81
type: UnificationXref
id: P35213
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2
type: ProteinReference
xref: uniprot Q5CZQ1 121
xref: PTHR18860:SF17
organism: Danio rerio

uniprot Q4KM68 584
type: UnificationXref
id: Q4KM68
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 58

uniprot Q5F3W6 123
type: UnificationXref
id: Q5F3W6
db: uniprot

uniprot Q9Y884 933
type: UnificationXref
id: Q9Y884
db: uniprot

uniprot Q9VBJ2 372
type: UnificationXref
id: Q9VBJ2
db: uniprot

uniprot K7DK66 655
type: UnificationXref
id: K7DK66
db: uniprot

uniprot P92208 330
type: UnificationXref
id: P92208
db: uniprot

uniprot F1P750 705
type: UnificationXref
id: F1P750
db: uniprot

uniprot P10506 913
type: UnificationXref
id: P10506
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2R0G7 322
organism: Pan troglodytes

uniprot Q7RYH5 902
type: UnificationXref
id: Q7RYH5
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2KYF8 238
organism: Caenorhabditis elegans

uniprot Q5ZLW4 731
type: UnificationXref
id: Q5ZLW4
db: uniprot

uniprot P05625 951
type: UnificationXref
id: P05625
db: uniprot

uniprot P42225 989
type: UnificationXref
id: P42225
db: uniprot

uniprot H2RC65 355
type: UnificationXref
id: H2RC65
db: uniprot

uniprot P34147 1096
type: UnificationXref
id: P34147
db: uniprot

EGF
type: Protein
entity reference: EGF
comment: SPECIES_TYPE=PROTEIN

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Survival Apoptosis cell migration
controller: p38

uniprot P54676 861
type: UnificationXref
id: P54676
db: uniprot

Phosphatidylethanolamine-binding protein 2
type: ProteinReference
xref: uniprot Q8VIN1 521
organism: Mus musculus

Gab
type: ProteinReference
xref: P00563
standard name: GRB2-associated binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: GRB2-associated binding protein Synonym: growth factor receptor bound protein 2-associated binding protein Accession: P00563
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Gab
member entity reference: GAB1 isoform 1
member entity reference: GRB2 associated binding protein 1
member entity reference: Pleckstrin homology like domain family B member 2
member entity reference: GRB2-associated-binding protein 2
member entity reference: GRB2-associated-binding protein 1
member entity reference: GRB2-associated-binding protein 3
member entity reference: Uncharacterized protein
member entity reference: GAB3 isoform 2
member entity reference: GAB2 isoform 1
member entity reference: Protein daughter of sevenless
member entity reference: Pleckstrin homology-like domain family B member 2

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK4,7-RIGHT__MKK4,7-_r23
controller: MEKK1-5

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot E2RR18 1147
xref: PTHR22968:SF12
organism: Canis lupus familiaris

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot F6VAQ8 825
organism: Ornithorhynchus anatinus

Receptor tyrosine-protein kinase erbB-3
type: ProteinReference
xref: uniprot P21860 210
xref: PTHR24416:SF88
organism: Homo sapiens

uniprot F6UB42 824
type: UnificationXref
id: F6UB42
db: uniprot

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: PTHR48013:SF12
xref: uniprot Q925D6 166
organism: Rattus norvegicus

uniprot O08911 1023
type: UnificationXref
id: O08911
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot A0A2I3T7A8 801
organism: Pan troglodytes

PTHR18860:SF115
type: RelationshipXref
id: PTHR18860:SF115
db: PANTHER Family
relationship type: By Homology

uniprot F1M9D0 702
type: UnificationXref
id: F1M9D0
db: uniprot

PTHR18860:SF112
type: RelationshipXref
id: PTHR18860:SF112
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E1BMG4 1140
organism: Bos taurus

uniprot P70618 1031
type: UnificationXref
id: P70618
db: uniprot

14-3-3-like protein GF14 omicron
type: ProteinReference
xref: PTHR18860:SF31
xref: uniprot Q9S9Z8 148
organism: Arabidopsis thaliana

Protein kinase C eta type
type: ProteinReference
xref: uniprot P24723 1186
xref: PTHR24356:SF192
organism: Homo sapiens

uniprot P27638 245
type: UnificationXref
id: P27638
db: uniprot

uniprot F6TY10 46
type: UnificationXref
id: F6TY10
db: uniprot

uniprot Q9CQV8 147
type: UnificationXref
id: Q9CQV8
db: uniprot

uniprot P16054 1181
type: UnificationXref
id: P16054
db: uniprot

uniprot P42230 994
type: UnificationXref
id: P42230
db: uniprot

uniprot P25390 723
type: UnificationXref
id: P25390
db: uniprot

uniprot O04376 431
type: UnificationXref
id: O04376
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P49186 326
organism: Rattus norvegicus

uniprot F6XMN6 1154
type: UnificationXref
id: F6XMN6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TKL3 313
organism: Xenopus tropicalis

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P49187 327
xref: PTHR24055:SF162
organism: Rattus norvegicus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7E5M4 419
xref: PTHR45619:SF44
organism: Ornithorhynchus anatinus

uniprot Q9DGE2 1042
type: UnificationXref
id: Q9DGE2
db: uniprot

uniprot A0A1D5QAR1 619
type: UnificationXref
id: A0A1D5QAR1
db: uniprot

Uncharacterized protein, isoform B
type: ProteinReference
xref: uniprot Q9VXB7 491
organism: Drosophila melanogaster

uniprot Q19019 298
type: UnificationXref
id: Q19019
db: uniprot

PTHR18860:SF106
type: RelationshipXref
id: PTHR18860:SF106
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5RA78 1048
type: UnificationXref
id: A0A1D5RA78
db: uniprot

uniprot P01112 659
type: UnificationXref
id: P01112
db: uniprot

uniprot F1Q118 884
type: UnificationXref
id: F1Q118
db: uniprot

PTHR10257:SF3
type: RelationshipXref
id: PTHR10257:SF3
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF101
type: RelationshipXref
id: PTHR18860:SF101
db: PANTHER Family
relationship type: By Homology

uniprot A0A0G2JTA7 335
type: UnificationXref
id: A0A0G2JTA7
db: uniprot

PTHR10257:SF4
type: RelationshipXref
id: PTHR10257:SF4
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RFQ9 1049
xref: PTHR45960:SF1
organism: Macaca mulatta

Dual specificity mitogen-activated protein kinase kinase dSOR1
type: ProteinReference
xref: uniprot Q24324 924
xref: PTHR48013:SF19
organism: Drosophila melanogaster

PTHR18860:SF103
type: RelationshipXref
id: PTHR18860:SF103
db: PANTHER Family
relationship type: By Homology

PTHR10257:SF6
type: RelationshipXref
id: PTHR10257:SF6
db: PANTHER Family
relationship type: By Homology

uniprot Q02156 1198
type: UnificationXref
id: Q02156
db: uniprot

Sprouty homolog 4 (Drosophila)
type: DnaReference
xref: PTHR12365:SF6
organism: Danio rerio

uniprot Q96299 146
type: UnificationXref
id: Q96299
db: uniprot

Ras-related protein M-Ras
type: ProteinReference
xref: uniprot P97538 680
organism: Rattus norvegicus

ncbitaxon 45351 387
type: UnificationXref
id: 45351
db: ncbitaxon

PTHR10337:SF11
type: RelationshipXref
id: PTHR10337:SF11
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF109
type: RelationshipXref
id: PTHR18860:SF109
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9LV37 282
organism: Arabidopsis thaliana

uniprot Q5B4M9 119
type: UnificationXref
id: Q5B4M9
db: uniprot

14-3-3 protein theta
type: ProteinReference
xref: uniprot Q3SZI4 118
xref: PTHR18860:SF3
organism: Bos taurus

uniprot Q6DGB7 1112
type: UnificationXref
id: Q6DGB7
db: uniprot

uniprot Q9ZQY6 493
type: UnificationXref
id: Q9ZQY6
db: uniprot

STATE_TRANSITION_LEFT__EGFR-RIGHT__EGFR-_r56
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 1294
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 1295
left: EGFR
interaction type: STATE_TRANSITION
right: EGFR

uniprot Q24151 1003
type: UnificationXref
id: Q24151
db: uniprot

Mitogen-activated protein kinase hog-1
type: ProteinReference
xref: uniprot Q96TL5 1040
organism: Neurospora crassa

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
type: ProteinReference
xref: uniprot H2QHF1 63
xref: PTHR18860:SF3
organism: Pan troglodytes

uniprot H2PZQ7 651
type: UnificationXref
id: H2PZQ7
db: uniprot

uniprot F1MX38 972
type: UnificationXref
id: F1MX38
db: uniprot

uniprot E2RE22 970
type: UnificationXref
id: E2RE22
db: uniprot

uniprot E2QVP6 27
type: UnificationXref
id: E2QVP6
db: uniprot

uniprot Q9C004 189
type: UnificationXref
id: Q9C004
db: uniprot

Rac-like GTP-binding protein ARAC8
type: ProteinReference
xref: uniprot Q9SU67 1128
organism: Arabidopsis thaliana

SHC adaptor protein 3
type: ProteinReference
xref: uniprot F1PPW0 745
xref: PTHR10337:SF4
organism: Canis lupus familiaris

uniprot W4ZAK5 494
type: UnificationXref
id: W4ZAK5
db: uniprot

uniprot A0A2I3TNY5 966
type: UnificationXref
id: A0A2I3TNY5
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
type: ProteinReference
xref: uniprot F7DY42 57
xref: PTHR18860:SF17
organism: Xenopus tropicalis

uniprot Q4QGB0 925
type: UnificationXref
id: Q4QGB0
db: uniprot

uniprot Q8IN89 481
type: UnificationXref
id: Q8IN89
db: uniprot

uniprot Q8AXX6 480
type: UnificationXref
id: Q8AXX6
db: uniprot

uniprot H2QS62 321
type: UnificationXref
id: H2QS62
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Mitogenesis Differentiation
controller: ERK1-2

STAT
type: Protein
entity reference: STAT
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa10 1234
feature: ACTIVE 167
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

PTHR23007:SF5
type: RelationshipXref
id: PTHR23007:SF5
db: PANTHER Family
relationship type: By Homology

PTHR48013:SF12
type: RelationshipXref
id: PTHR48013:SF12
db: PANTHER Family
relationship type: By Homology

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

PTHR23007:SF3
type: RelationshipXref
id: PTHR23007:SF3
db: PANTHER Family
relationship type: By Homology

AGAP002049-PA
type: ProteinReference
xref: uniprot Q380S1 516
organism: Anopheles gambiae

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot H2QHR7 1168
organism: Pan troglodytes

uniprot Q8IS21 904
type: UnificationXref
id: Q8IS21
db: uniprot

uniprot Q08012 582
type: UnificationXref
id: Q08012
db: uniprot

PTHR48013:SF17
type: RelationshipXref
id: PTHR48013:SF17
db: PANTHER Family
relationship type: By Homology

uniprot P01119 660
type: UnificationXref
id: P01119
db: uniprot

uniprot F6Y478 52
type: UnificationXref
id: F6Y478
db: uniprot

uniprot P53778 1030
type: UnificationXref
id: P53778
db: uniprot

PTHR48013:SF19
type: RelationshipXref
id: PTHR48013:SF19
db: PANTHER Family
relationship type: By Homology

Protein BMH1
type: ProteinReference
xref: uniprot P29311 76
xref: PTHR18860:SF17
organism: Saccharomyces cerevisiae

14-3-3 protein zeta
type: ProteinReference
xref: uniprot P29310 74
xref: PTHR18860:SF106
organism: Drosophila melanogaster

PTHR24416:SF566
type: RelationshipXref
id: PTHR24416:SF566
db: PANTHER Family
relationship type: By Homology

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 608
organism: Homo sapiens

uniprot F7BIC2 1157
type: UnificationXref
id: F7BIC2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZLW4 731
organism: Gallus gallus

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 607
organism: Mus musculus

PTHR24356:SF240
type: RelationshipXref
id: PTHR24356:SF240
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5RFQ9 1049
type: UnificationXref
id: A0A1D5RFQ9
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 12

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9WUA6 616
xref: PTHR24356:SF190
organism: Mus musculus

uniprot F1MYM3 819
type: UnificationXref
id: F1MYM3
db: uniprot

uniprot O15264 1024
type: UnificationXref
id: O15264
db: uniprot

MEKK1-5
type: ProteinReference
xref: P00553
standard name: Mitogen-activated protein kinase kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen-activated protein kinase kinase kinase Synonym: MAPK/ERK kinase kinase,MEK kinase Accession: P00553
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.MEKK1_minus_5
member entity reference: MAP3K5 isoform 1
member entity reference: MAP kinase kinase kinase mkh1
member entity reference: Mitogen-activated protein kinase kinase kinase 1
member entity reference: Mitogen-activated protein kinase kinase kinase nsy-1
member entity reference: Mitogen-activated protein kinase kinase kinase 5
member entity reference: MAP kinase kinase kinase wis4
member entity reference: MAP kinase kinase kinase
member entity reference: Uncharacterized protein
member entity reference: MTK1/MEKK4 homolog
member entity reference: Mitogen-activated protein kinase kinase kinase 3
member entity reference: MAP3K2 isoform 1
member entity reference: Mitogen-activated protein kinase kinase kinase 2
member entity reference: Serine/threonine-protein kinase BCK1/SLK1/SSP31
member entity reference: Mitogen-activated protein kinase kinase kinase A
member entity reference: Map3k3 protein
member entity reference: Mitogen-activated protein kinase kinase kinase 4
member entity reference: Serine/threonine-protein kinase STE11
member entity reference: Mitogen-activated protein kinase kinase kinase 3 isoform 1
member entity reference: Serine/threonine-protein kinase SSK22
member entity reference: MAP kinase kinase kinase SSK2
member entity reference: Cerebral cavernous malformations protein 2 homolog
member entity reference: Apoptotic signal-regulating kinase 1, isoform C
member entity reference: MAP kinase kinase kinase win1

uniprot P63001 1103
type: UnificationXref
id: P63001
db: uniprot

PTHR18860:SF125
type: RelationshipXref
id: PTHR18860:SF125
db: PANTHER Family
relationship type: By Homology

PTHR48013:SF21
type: RelationshipXref
id: PTHR48013:SF21
db: PANTHER Family
relationship type: By Homology

PTHR48013:SF20
type: RelationshipXref
id: PTHR48013:SF20
db: PANTHER Family
relationship type: By Homology

Rac-like GTP-binding protein ARAC2
type: ProteinReference
xref: PTHR24072:SF300
xref: uniprot Q38903 1107
organism: Arabidopsis thaliana

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31749 606
organism: Homo sapiens

uniprot K7CBH8 1170
type: UnificationXref
id: K7CBH8
db: uniprot

uniprot K7BYT0 912
type: UnificationXref
id: K7BYT0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot F7BVQ1 785
organism: Monodelphis domestica

uniprot P06494 209
type: UnificationXref
id: P06494
db: uniprot

uniprot F1MCQ7 198
type: UnificationXref
id: F1MCQ7
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
control type: INHIBITION
controller: Akt

14-3-3-like protein 2
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot Q20655 115
organism: Caenorhabditis elegans

uniprot E2RNP2 1146
type: UnificationXref
id: E2RNP2
db: uniprot

uniprot O96390 1091
type: UnificationXref
id: O96390
db: uniprot

Pleckstrin homology like domain family B member 2
type: ProteinReference
xref: uniprot H2RB91 1061
organism: Pan troglodytes

Epidermal growth factor receptor
type: ProteinReference
xref: PTHR24416:SF91
xref: uniprot Q01279 213
organism: Mus musculus

uniprot A8XQR9 18
type: UnificationXref
id: A8XQR9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2I3RG08 744
xref: PTHR10337:SF4
organism: Pan troglodytes

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot H2QD19 984
xref: PTHR11801:SF47
organism: Pan troglodytes

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 20

uniprot F1PBL1 35
type: UnificationXref
id: F1PBL1
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot E1C6T4 1143
organism: Gallus gallus

STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1281
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1283
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1282
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1280
left: Ras
left: GDP
interaction type: STATE_TRANSITION
right: Ras
right: GTP

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P08487 787
xref: PTHR10336:SF173
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot A0A2I3SR38 1133
organism: Pan troglodytes

PTHR24356:SF214
type: RelationshipXref
id: PTHR24356:SF214
db: PANTHER Family
relationship type: By Homology

uniprot Q61526 215
type: UnificationXref
id: Q61526
db: uniprot

uniprot F6QE96 598
type: UnificationXref
id: F6QE96
db: uniprot

uniprot P62071 678
type: UnificationXref
id: P62071
db: uniprot

14-3-3 protein 3
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot C4M0F4 25
organism: Entamoeba histolytica

JNK1 3 s50 a63 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot O04951 432
type: UnificationXref
id: O04951
db: uniprot

STATE_TRANSITION_LEFT__EGFR-RIGHT__EGFR-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1265
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1264
left: EGFR
interaction type: STATE_TRANSITION
right: EGFR

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F6X0X1 414
xref: PTHR10257:SF19
organism: Ornithorhynchus anatinus

STATE_TRANSITION_LEFT__EGFR-RIGHT__EGFR-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 1266
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 1267
left: EGFR
interaction type: STATE_TRANSITION
right: EGFR

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot F7GWP9 421
organism: Macaca mulatta

uniprot F7GY91 1088
type: UnificationXref
id: F7GY91
db: uniprot

PTHR11362:SF109
type: RelationshipXref
id: PTHR11362:SF109
db: PANTHER Family
relationship type: By Homology

Predicted protein
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot A7STP5 626
organism: Nematostella vectensis

Rac-like GTP-binding protein ARAC4
type: ProteinReference
xref: uniprot Q38919 1108
organism: Arabidopsis thaliana

Receptor protein-tyrosine kinase
type: ProteinReference
xref: PTHR24416:SF137
xref: uniprot F1MCQ7 198
organism: Bos taurus

uniprot Q68SP3 1004
type: UnificationXref
id: Q68SP3
db: uniprot

uniprot A0A2I3RF60 195
type: UnificationXref
id: A0A2I3RF60
db: uniprot

Protein RICE FLOWERING LOCUS T 1
type: ProteinReference
xref: uniprot Q8VWH2 522
organism: Oryza sativa

ncbitaxon 9598 8
type: UnificationXref
id: 9598
db: ncbitaxon

Protein sprouty homolog 1
type: DnaReference
xref: PTHR12365:SF10
organism: Bos taurus

RAC serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF333
xref: uniprot Q8INB9 614
organism: Drosophila melanogaster

Protein sprouty homolog 2
type: DnaReference
xref: PTHR12365:SF8
organism: Gallus gallus

uniprot A0A0G2JZD5 1047
type: UnificationXref
id: A0A0G2JZD5
db: uniprot

uniprot P00533 206
type: UnificationXref
id: P00533
db: uniprot

Extracellular signal-regulated kinase 2
type: ProteinReference
xref: uniprot Q54QB1 265
organism: Dictyostelium discoideum

uniprot Q16539 1034
type: UnificationXref
id: Q16539
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 124

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q6GLE6 467
xref: PTHR45619:SF44
organism: Xenopus tropicalis

JNK1 3 s50 a63 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot O61444 770
type: UnificationXref
id: O61444
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot C3ZG26 399
organism: Branchiostoma floridae

uniprot P52631 998
type: UnificationXref
id: P52631
db: uniprot

14-3-3 protein
type: ProteinReference
xref: uniprot A8JGV6 13
xref: PTHR18860:SF115
organism: Chlamydomonas reinhardtii

uniprot A0A1D5QAB6 337
type: UnificationXref
id: A0A1D5QAB6
db: uniprot

Survival Apoptosis cell migration
type: Pathway

Ras-like protein
type: ProteinReference
xref: uniprot P0CQ42 668
xref: PTHR24070:SF17
organism: Cryptococcus neoformans

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q5PU49 1207
xref: PTHR24356:SF365
organism: Canis lupus familiaris

Rac family small GTPase 1a
type: ProteinReference
xref: uniprot Q7ZSZ9 1120
xref: PTHR24072:SF105
organism: Danio rerio

uniprot Q6JHX4 691
type: UnificationXref
id: Q6JHX4
db: uniprot

uniprot P92177 109
type: UnificationXref
id: P92177
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot H9FU32 947
organism: Macaca mulatta

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q9LM33 280
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F7F5X1 647
organism: Monodelphis domestica

uniprot E2RCV1 813
type: UnificationXref
id: E2RCV1
db: uniprot

uniprot F6R1P6 975
type: UnificationXref
id: F6R1P6
db: uniprot

uniprot E2RM91 290
type: UnificationXref
id: E2RM91
db: uniprot

PI3K
type: Protein
entity reference: PI3K
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa11 1236
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot Q9Y6R4 742
type: UnificationXref
id: Q9Y6R4
db: uniprot

uniprot F7GAV2 202
type: UnificationXref
id: F7GAV2
db: uniprot

ncbitaxon 9913 12
type: UnificationXref
id: 9913
db: ncbitaxon

14-3-3-like protein GF14-A
type: ProteinReference
xref: uniprot Q84J55 145
xref: PTHR18860:SF83
organism: Oryza sativa

uniprot A0A3Q1LUB2 288
type: UnificationXref
id: A0A3Q1LUB2
db: uniprot

PTHR15593:SF2
type: RelationshipXref
id: PTHR15593:SF2
db: PANTHER Family
relationship type: By Homology

uniprot P34722 1188
type: UnificationXref
id: P34722
db: uniprot

uniprot Q8WQG9 332
type: UnificationXref
id: Q8WQG9
db: uniprot

uniprot A6QR62 197
type: UnificationXref
id: A6QR62
db: uniprot

uniprot C4M323 26
type: UnificationXref
id: C4M323
db: uniprot

PIK3R5 isoform 2
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot A0A2J8MGP0 803
organism: Pan troglodytes

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q28GT8 461
organism: Xenopus tropicalis

NF1 isoform 1
type: ProteinReference
xref: PTHR10194:SF60
xref: uniprot H2QCM0 352
organism: Pan troglodytes

Mitogen-activated protein kinase sty1
type: ProteinReference
xref: uniprot Q09892 1032
organism: Schizosaccharomyces pombe

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A1D5R6N7 377
xref: PTHR10257:SF19
organism: Macaca mulatta

JNK1-3
type: Protein
entity reference: JNK1-3
feature: JNK1 3 s40 a42 rs1
feature: JNK1 3 s40 a42 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot Q9FJV0 930
organism: Arabidopsis thaliana

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot E2RCV1 813
organism: Canis lupus familiaris

uniprot Q04759 1200
type: UnificationXref
id: Q04759
db: uniprot

uniprot G5EBK8 649
type: UnificationXref
id: G5EBK8
db: uniprot

Phosphatidylethanolamine-binding protein homolog F40A3.3
type: ProteinReference
xref: uniprot O16264 506
organism: Caenorhabditis elegans

PTHR11584:SF332
type: RelationshipXref
id: PTHR11584:SF332
db: PANTHER Family
relationship type: By Homology

GTPase NRas
type: ProteinReference
xref: uniprot Q5F352 689
xref: PTHR24070:SF189
organism: Gallus gallus

uniprot F1Q6Z7 409
type: UnificationXref
id: F1Q6Z7
db: uniprot

uniprot Q6Z808 1118
type: UnificationXref
id: Q6Z808
db: uniprot

uniprot Q9N272 1043
type: UnificationXref
id: Q9N272
db: uniprot

Rac-like GTP-binding protein 1
type: ProteinReference
xref: PTHR24072:SF289
xref: uniprot Q9SSX0 1127
organism: Oryza sativa

Son of sevenless homolog 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot Q02384 893
organism: Mus musculus

Probetacellulin
type: ProteinReference
xref: uniprot P35070 564
organism: Homo sapiens

uniprot P36507 918
type: UnificationXref
id: P36507
db: uniprot

uniprot H2QNG6 840
type: UnificationXref
id: H2QNG6
db: uniprot

uniprot Q9VI08 532
type: UnificationXref
id: Q9VI08
db: uniprot

uniprot A0A1D5RFE7 286
type: UnificationXref
id: A0A1D5RFE7
db: uniprot

Mitogen-activated protein kinase 15
type: ProteinReference
xref: uniprot Q9C9U4 278
organism: Arabidopsis thaliana

uniprot D3ZV15 289
type: UnificationXref
id: D3ZV15
db: uniprot

Os01g0748800 protein
type: ProteinReference
xref: uniprot A0A0P0V857 496
organism: Oryza sativa

uniprot O70142 748
type: UnificationXref
id: O70142
db: uniprot

Ras homolog family member Gb
type: ProteinReference
xref: uniprot Q803F2 1122
organism: Danio rerio

Ras-related protein R-Ras
type: ProteinReference
xref: PTHR24070:SF245
xref: uniprot P10833 670
organism: Mus musculus

Cerebral cavernous malformations protein 2 homolog
type: ProteinReference
xref: uniprot Q6DRP4 735
organism: Danio rerio

uniprot D3ZJA3 172
type: UnificationXref
id: D3ZJA3
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot E1BQN6 1141
organism: Gallus gallus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F6R1P6 975
organism: Macaca mulatta

uniprot E2RGU9 173
type: UnificationXref
id: E2RGU9
db: uniprot

ncbitaxon 6238 17
type: UnificationXref
id: 6238
db: ncbitaxon

PTHR11362:SF131
type: RelationshipXref
id: PTHR11362:SF131
db: PANTHER Family
relationship type: By Homology

uniprot A8WR64 1137
type: UnificationXref
id: A8WR64
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6R8N3 600
xref: PTHR24356:SF190
organism: Macaca mulatta

uniprot Q19266 1205
type: UnificationXref
id: Q19266
db: uniprot

uniprot F7E823 234
type: UnificationXref
id: F7E823
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6VXG1 827
organism: Xenopus tropicalis

14-3-3 protein, putative
type: ProteinReference
xref: uniprot Q5K8Z6 125
xref: PTHR18860:SF17
organism: Cryptococcus neoformans

Protein kinase C eta type
type: ProteinReference
xref: uniprot H2Q8F2 1165
xref: PTHR24356:SF192
organism: Pan troglodytes

uniprot P62258 96
type: UnificationXref
id: P62258
db: uniprot

uniprot F1MAA3 404
type: UnificationXref
id: F1MAA3
db: uniprot

uniprot A0A2I3T9Y4 590
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

uniprot F1PMN2 312
type: UnificationXref
id: F1PMN2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7D0A6 767
xref: PTHR48013:SF17
organism: Monodelphis domestica

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot Q803G3 478
organism: Danio rerio

uniprot Q960A2 736
type: UnificationXref
id: Q960A2
db: uniprot

uniprot Q9WTU6 334
type: UnificationXref
id: Q9WTU6
db: uniprot

AGAP000310-PA
type: ProteinReference
xref: uniprot Q7PRZ7 165
organism: Anopheles gambiae

Protransforming growth factor alpha
type: ProteinReference
xref: PTHR10740:SF1
xref: uniprot P48030 566
organism: Mus musculus

By Homology
type: RelationshipTypeVocabulary

uniprot F7GTQ2 1161
type: UnificationXref
id: F7GTQ2
db: uniprot

uniprot Q60996 464
type: UnificationXref
id: Q60996
db: uniprot

uniprot Q9XT09 932
type: UnificationXref
id: Q9XT09
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot H2QT14 427
xref: PTHR10257:SF89
organism: Pan troglodytes

uniprot Q05928 570
type: UnificationXref
id: Q05928
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 113

uniprot Q90XF2 1216
type: UnificationXref
id: Q90XF2
db: uniprot

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot Q5ZLQ6 132
organism: Gallus gallus

uniprot Q9SV41 489
type: UnificationXref
id: Q9SV41
db: uniprot

uniprot P98077 751
type: UnificationXref
id: P98077
db: uniprot

uniprot P63086 252
type: UnificationXref
id: P63086
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q6P943 1006
xref: PTHR11801:SF18
organism: Danio rerio

uniprot H2QPP5 550
type: UnificationXref
id: H2QPP5
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot P01111 658
xref: PTHR24070:SF189
organism: Homo sapiens

uniprot Q8K1Y2 1215
type: UnificationXref
id: Q8K1Y2
db: uniprot

14-3-3 protein gamma
type: ProteinReference
xref: uniprot A7Z057 11
xref: PTHR18860:SF22
organism: Bos taurus

GTPase HRas
type: ProteinReference
xref: uniprot P01112 659
xref: PTHR24070:SF385
organism: Homo sapiens

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P28867 1187
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F6Z879 766
organism: Monodelphis domestica

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A9RVI2 389
organism: Physcomitrella patens

uniprot H2Q6Z4 504
type: UnificationXref
id: H2Q6Z4
db: uniprot

uniprot D3ZDI7 400
type: UnificationXref
id: D3ZDI7
db: uniprot

uniprot P63085 251
type: UnificationXref
id: P63085
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit A
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot Q9XZE5 492
organism: Dictyostelium discoideum

uniprot Q04982 958
type: UnificationXref
id: Q04982
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G6M6 178
organism: Macaca mulatta

uniprot F7BWW9 888
type: UnificationXref
id: F7BWW9
db: uniprot

Pro-neuregulin-4, membrane-bound isoform
type: ProteinReference
xref: uniprot Q9WTX4 578
organism: Mus musculus

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

uniprot Q9QXV8 191
type: UnificationXref
id: Q9QXV8
db: uniprot

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

SHC
type: Protein
entity reference: SHC
feature: ACTIVE 167
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa12 1238
feature: SHC s11 sa12 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A2I3RZ31 306
xref: PTHR24055:SF162
organism: Pan troglodytes

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
type: ProteinReference
xref: uniprot Q13362 456
xref: PTHR10257:SF19
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7A632 1156
organism: Monodelphis domestica

GRB2-associated-binding protein 3
type: ProteinReference
xref: PTHR45960:SF3
xref: uniprot Q8WWW8 1066
organism: Homo sapiens

uniprot Q10428 454
type: UnificationXref
id: Q10428
db: uniprot

ncbitaxon 9258 51
type: UnificationXref
id: 9258
db: ncbitaxon

GH14779p
type: ProteinReference
xref: uniprot Q9VD02 531
organism: Drosophila melanogaster

LP12095p
type: ProteinReference
xref: uniprot Q9VD01 530
organism: Drosophila melanogaster

uniprot Q6LC82 1115
type: UnificationXref
id: Q6LC82
db: uniprot

Mitogen-activated protein kinase kinase kinase nsy-1
type: ProteinReference
xref: uniprot Q21029 729
organism: Caenorhabditis elegans

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot A0A1D5QAU9 761
organism: Macaca mulatta

uniprot F6UMM2 977
type: UnificationXref
id: F6UMM2
db: uniprot

PARTICIPANT STOICHIOMETRY r58 1288
type: Stoichiometry
physical entity: Complex (EGFR/Grb2/ SOS)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 1287
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

PARTICIPANT STOICHIOMETRY r58 1286
type: Stoichiometry
physical entity: Complex (Grb2/SOS)
stoichiometric coefficient: 1.0

uniprot G5EGA7 650
type: UnificationXref
id: G5EGA7
db: uniprot

PTHR24070:SF380
type: RelationshipXref
id: PTHR24070:SF380
db: PANTHER Family
relationship type: By Homology

uniprot H2QRP3 182
type: UnificationXref
id: H2QRP3
db: uniprot

uniprot C4M0F4 25
type: UnificationXref
id: C4M0F4
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q91Y86 333
organism: Mus musculus

uniprot Q06175 571
type: UnificationXref
id: Q06175
db: uniprot

Protein sprouty homolog 4
type: DnaReference
xref: PTHR12365:SF6
organism: Homo sapiens

uniprot Q7Q334 756
type: UnificationXref
id: Q7Q334
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: PTHR48013:SF12
xref: uniprot P52564 162
organism: Homo sapiens

uniprot A0A0D1C4Y4 223
type: UnificationXref
id: A0A0D1C4Y4
db: uniprot

uniprot Q9FXT7 279
type: UnificationXref
id: Q9FXT7
db: uniprot

uniprot Q84J55 145
type: UnificationXref
id: Q84J55
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9WTY9 1044
organism: Rattus norvegicus

PTHR10257:SF80
type: RelationshipXref
id: PTHR10257:SF80
db: PANTHER Family
relationship type: By Homology

MKK4,7 s39 a41 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot H2R8U9 889
xref: PTHR23113:SF168
organism: Pan troglodytes

uniprot K7CW85 654
type: UnificationXref
id: K7CW85
db: uniprot

uniprot F6VTR8 826
type: UnificationXref
id: F6VTR8
db: uniprot

Cbl proto-oncogene, E3 ubiquitin protein ligase
type: ProteinReference
xref: uniprot F1QI90 292
organism: Danio rerio

uniprot F7D0A6 767
type: UnificationXref
id: F7D0A6
db: uniprot

PTHR10257:SF89
type: RelationshipXref
id: PTHR10257:SF89
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: PTHR48013:SF12
xref: uniprot F7AGV5 156
organism: Monodelphis domestica

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 395

uniprot F7C798 1021
type: UnificationXref
id: F7C798
db: uniprot

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

uniprot H2QIN7 713
type: UnificationXref
id: H2QIN7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot D4A779 1054
organism: Rattus norvegicus

uniprot Q5ZKC9 130
type: UnificationXref
id: Q5ZKC9
db: uniprot

uniprot Q9LVE2 488
type: UnificationXref
id: Q9LVE2
db: uniprot

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

uniprot Q02158 792
type: UnificationXref
id: Q02158
db: uniprot

PTHR12365:SF6
type: RelationshipXref
id: PTHR12365:SF6
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r26 1292
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

PTHR12365:SF7
type: RelationshipXref
id: PTHR12365:SF7
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r26 1293
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

PTHR24072:SF325
type: RelationshipXref
id: PTHR24072:SF325
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot F7H9J1 711
organism: Macaca mulatta

AGAP008909-PA
type: ProteinReference
xref: uniprot Q7PWN1 519
organism: Anopheles gambiae

PTHR12365:SF8
type: RelationshipXref
id: PTHR12365:SF8
db: PANTHER Family
relationship type: By Homology

uniprot O45818 1171
type: UnificationXref
id: O45818
db: uniprot

PTHR10257:SF92
type: RelationshipXref
id: PTHR10257:SF92
db: PANTHER Family
relationship type: By Homology

DShc protein
type: ProteinReference
xref: PTHR10337:SF11
xref: uniprot Q9V3C8 760
organism: Drosophila melanogaster

uniprot A0A2I3SB47 762
type: UnificationXref
id: A0A2I3SB47
db: uniprot

uniprot O22042 719
type: UnificationXref
id: O22042
db: uniprot

EGFR
type: Complex
component stoichiometry: EGFR s129 a46 STOICHIOMETRY ID COMPLEX
component: EGFR
feature: ACTIVE 167
cellular location: cytosol

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
type: ProteinReference
xref: uniprot H2QLJ0 64
xref: PTHR18860:SF16
organism: Pan troglodytes

uniprot Q5ANK2 1206
type: UnificationXref
id: Q5ANK2
db: uniprot

EGFR
type: Complex
component stoichiometry: EGFR s1 sa3 STOICHIOMETRY ID COMPLEX
component: EGFR
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa3 1220
feature: ACTIVE 167
cellular location: cytosol

uniprot E2R9L4 701
type: UnificationXref
id: E2R9L4
db: uniprot

EGFR
type: Complex
component stoichiometry: EGFR s5 sa8 STOICHIOMETRY ID COMPLEX
component: EGFR
feature: ACTIVE 167
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa8 1230
cellular location: cytosol

Serine/threonine-protein phosphatase 4 catalytic subunit
type: ProteinReference
xref: uniprot P32345 437
organism: Saccharomyces cerevisiae

Rac family small GTPase 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q5U1Y2 1110
organism: Rattus norvegicus

Cbl long isoform
type: ProteinReference
xref: uniprot Q9VSK2 303
organism: Drosophila melanogaster

Spry
type: Protein
entity reference: Spry
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Rho family GTPase
type: ProteinReference
xref: uniprot C4M5Q7 1076
xref: PTHR24072:SF281
organism: Entamoeba histolytica

ncbitaxon 214684 126
type: UnificationXref
id: 214684
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR23007:SF3
xref: uniprot A0A1D5Q8S8 285
organism: Macaca mulatta

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot Q7PX08 140
xref: PTHR18860:SF17
organism: Anopheles gambiae

uniprot Q6P730 366
type: UnificationXref
id: Q6P730
db: uniprot

uniprot P45985 771
type: UnificationXref
id: P45985
db: uniprot

uniprot E9I1I7 634
type: UnificationXref
id: E9I1I7
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot Q0IIE2 753
organism: Bos taurus

Sprouty RTK-signaling antagonist 2
type: ProteinReference
xref: uniprot Q5Y173 188
xref: PTHR12365:SF8
organism: Xenopus tropicalis

uniprot E1C5A3 401
type: UnificationXref
id: E1C5A3
db: uniprot

uniprot F7GZA8 351
type: UnificationXref
id: F7GZA8
db: uniprot

PTHR24072:SF310
type: RelationshipXref
id: PTHR24072:SF310
db: PANTHER Family
relationship type: By Homology

Receptor protein-tyrosine kinase
type: ProteinReference
xref: uniprot F6ZSZ9 200
xref: PTHR24416:SF90
organism: Monodelphis domestica

Ras-related protein R-Ras2 isoform a
type: ProteinReference
xref: uniprot A0A1D5QAR1 619
organism: Macaca mulatta

STAT s8 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: STAT
stoichiometric coefficient: 1.0

c-Cbl
type: Protein
entity reference: c-Cbl
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 246

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 139

14-3-3 zeta
type: ProteinReference
xref: PTHR18860:SF106
xref: uniprot A8XQR9 18
organism: Caenorhabditis briggsae

Sprouty RTK signaling antagonist 3
type: ProteinReference
xref: uniprot F1MIH6 174
organism: Bos taurus

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot Q68SP3 1004
organism: Danio rerio

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
type: ProteinReference
xref: uniprot Q60996 464
xref: PTHR10257:SF19
organism: Mus musculus

uniprot F1QZW4 177
type: UnificationXref
id: F1QZW4
db: uniprot

uniprot P22126 672
type: UnificationXref
id: P22126
db: uniprot

GH14494p
type: ProteinReference
xref: uniprot Q9VI09 533
organism: Drosophila melanogaster

uniprot A0A3Q1LTT9 1012
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

GH28351p
type: ProteinReference
xref: uniprot Q9VI08 532
organism: Drosophila melanogaster

uniprot A0A1D5R9U8 935
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

uniprot Q63844 269
type: UnificationXref
id: Q63844
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZGX8 644
xref: PTHR24070:SF245
organism: Macaca mulatta

uniprot Q5ZMG8 1111
type: UnificationXref
id: Q5ZMG8
db: uniprot

MKK3,6
type: Protein
entity reference: MKK3,6
feature: MKK3,6 s51 a64 rs2
feature: MKK3,6 s51 a64 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

GH13542p
type: ProteinReference
xref: uniprot Q8IR23 369
xref: PTHR10194:SF19
organism: Drosophila melanogaster

uniprot Q91Y86 333
type: UnificationXref
id: Q91Y86
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF4
xref: uniprot F1PV54 408
organism: Canis lupus familiaris

uniprot Q9VB23 490
type: UnificationXref
id: Q9VB23
db: uniprot

HRAS isoform 2
type: ProteinReference
xref: uniprot K7ALD7 653
xref: PTHR24070:SF385
organism: Pan troglodytes

uniprot P09215 1178
type: UnificationXref
id: P09215
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O02812 1022
xref: PTHR24055:SF110
organism: Canis lupus familiaris

Cbl proto-oncogene B
type: ProteinReference
xref: PTHR23007:SF3
xref: uniprot A0A3Q1LUB2 288
organism: Bos taurus

uniprot Q1KQ07 1002
type: UnificationXref
id: Q1KQ07
db: uniprot

uniprot Q9VI09 533
type: UnificationXref
id: Q9VI09
db: uniprot

RAS p21 protein activator 1
type: ProteinReference
xref: uniprot F7EPN2 350
xref: PTHR10194:SF19
organism: Ornithorhynchus anatinus

Protein kinase C-like
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P87253 1196
organism: Neurospora crassa

uniprot F6URW3 886
type: UnificationXref
id: F6URW3
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR15593:SF2
xref: uniprot F6VTR8 826
organism: Macaca mulatta

uniprot P05129 1175
type: UnificationXref
id: P05129
db: uniprot

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: uniprot Q7SHZ6 872
organism: Neurospora crassa

Serine/threonine-protein kinase D3
type: ProteinReference
xref: PTHR22968:SF26
xref: uniprot O94806 1172
organism: Homo sapiens

Proheparin-binding EGF-like growth factor
type: ProteinReference
xref: PTHR10740:SF4
xref: uniprot Q99075 575
organism: Homo sapiens

uniprot P91634 862
type: UnificationXref
id: P91634
db: uniprot

uniprot A4FV68 384
type: UnificationXref
id: A4FV68
db: uniprot

uniprot E2RGU7 1145
type: UnificationXref
id: E2RGU7
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF2
xref: uniprot F1MX38 972
organism: Bos taurus

uniprot Q7RWZ8 368
type: UnificationXref
id: Q7RWZ8
db: uniprot

Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform
type: ProteinReference
xref: uniprot Q9SV41 489
organism: Arabidopsis thaliana

uniprot P42644 85
type: UnificationXref
id: P42644
db: uniprot

Ras-related protein M-Ras
type: ProteinReference
xref: uniprot O08989 656
organism: Mus musculus

ncbitaxon 665079 226
type: UnificationXref
id: 665079
db: ncbitaxon

EGFR s1 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: EGFR
stoichiometric coefficient: 2.0

Proheparin-binding EGF-like growth factor
type: ProteinReference
xref: PTHR10740:SF4
xref: uniprot F7FK53 548
organism: Macaca mulatta

uniprot A0A3Q1LQK4 805
type: UnificationXref
id: A0A3Q1LQK4
db: uniprot

Ras homolog gene family, member Gc
type: ProteinReference
xref: uniprot Q803L7 1123
organism: Danio rerio

Uncharacterized protein rasC
type: ProteinReference
xref: uniprot F1A411 639
xref: PTHR24070:SF251
organism: Dictyostelium purpureum

uniprot Q9VD01 530
type: UnificationXref
id: Q9VD01
db: uniprot

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

uniprot Q7PMF0 870
type: UnificationXref
id: Q7PMF0
db: uniprot

uniprot Q0V9W8 114
type: UnificationXref
id: Q0V9W8
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 334
organism: Mus musculus

uniprot H2R3E1 1060
type: UnificationXref
id: H2R3E1
db: uniprot

uniprot A0A2I3RB56 150
type: UnificationXref
id: A0A2I3RB56
db: uniprot

p38
type: ProteinReference
xref: P00562
standard name: p38 mitogen activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: p38 MAP kinase Synonym: HOG,mitogen-activated protein kinase 11,mitogen-activated protein kinase 14 isoform 4 Accession: P00562
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.p38
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 14A
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase pmk-1
member entity reference: Mitogen-activated protein kinase HOG1
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase hog-1
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase 14B
member entity reference: Mitogen-activated protein kinase sty1
member entity reference: Mitogen-activated protein kinase pmk-2
member entity reference: Mitogen-activated protein kinase p38b
member entity reference: Mitogen-activated protein kinase p38a

uniprot O70456 70
type: UnificationXref
id: O70456
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F7G755 420
xref: PTHR10257:SF92
organism: Ornithorhynchus anatinus

uniprot H2Q4Y2 293
type: UnificationXref
id: H2Q4Y2
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7HSM1 423
xref: PTHR45619:SF44
organism: Macaca mulatta

Pro-epidermal growth factor
type: ProteinReference
xref: uniprot P01133 557
organism: Homo sapiens

uniprot Q8INB9 614
type: UnificationXref
id: Q8INB9
db: uniprot

Protransforming growth factor alpha
type: ProteinReference
xref: uniprot P01135 559
xref: PTHR10740:SF1
organism: Homo sapiens

Rop-family small GTPase
type: ProteinReference
xref: uniprot A9TLC7 1074
organism: Physcomitrella patens

Protransforming growth factor alpha
type: ProteinReference
xref: uniprot P01134 558
xref: PTHR10740:SF1
organism: Rattus norvegicus

MKK4,7 s39 a41 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot Q22070 793
type: UnificationXref
id: Q22070
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF4
xref: uniprot Q08DP7 451
organism: Bos taurus

uniprot P32485 1028
type: UnificationXref
id: P32485
db: uniprot

uniprot O18178 433
type: UnificationXref
id: O18178
db: uniprot

uniprot F7BYN4 979
type: UnificationXref
id: F7BYN4
db: uniprot

Pro-epidermal growth factor
type: ProteinReference
xref: uniprot A0A1D5QFG6 537
organism: Macaca mulatta

PI3K
type: Protein
entity reference: PI3K
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase A
type: ProteinReference
xref: uniprot Q54R82 730
xref: PTHR48012:SF20
organism: Dictyostelium discoideum

Disabled homolog 2-interacting protein
type: ProteinReference
xref: uniprot Q5VWQ8 365
xref: PTHR10194:SF26
organism: Homo sapiens

uniprot A0A2J8QY32 804
type: UnificationXref
id: A0A2J8QY32
db: uniprot

uniprot F6THF0 1084
type: UnificationXref
id: F6THF0
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q380Z0 462
organism: Trypanosoma brucei

uniprot Q6P365 468
type: UnificationXref
id: Q6P365
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 495

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9N272 1043
xref: PTHR24055:SF107
organism: Pan troglodytes

Protein CENTRORADIALIS-like
type: ProteinReference
xref: uniprot Q9ZNV5 536
organism: Arabidopsis thaliana

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot H2R5K3 714
organism: Pan troglodytes

uniprot Q94125 876
type: UnificationXref
id: Q94125
db: uniprot

Ras-like protein 2
type: ProteinReference
xref: uniprot P01120 661
xref: PTHR24070:SF17
organism: Saccharomyces cerevisiae

Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform
type: ProteinReference
xref: uniprot Q9LVE2 488
organism: Arabidopsis thaliana

PTHR11362:SF82
type: RelationshipXref
id: PTHR11362:SF82
db: PANTHER Family
relationship type: By Homology

Proepiregulin
type: ProteinReference
xref: uniprot Q61521 573
organism: Mus musculus

uniprot Q64617 1211
type: UnificationXref
id: Q64617
db: uniprot

uniprot Q10664 922
type: UnificationXref
id: Q10664
db: uniprot

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

uniprot Q803L7 1123
type: UnificationXref
id: Q803L7
db: uniprot

Receptor tyrosine-protein kinase erbB-4
type: ProteinReference
xref: uniprot Q61527 216
xref: PTHR24416:SF90
organism: Mus musculus

Receptor tyrosine-protein kinase erbB-3
type: ProteinReference
xref: uniprot Q61526 215
xref: PTHR24416:SF88
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TXC2 1017
xref: PTHR24055:SF107
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot V5IKE7 284
organism: Neurospora crassa

Ras-like protein 1
type: ProteinReference
xref: uniprot P01119 660
xref: PTHR24070:SF17
organism: Saccharomyces cerevisiae

uniprot F7G8G5 983
type: UnificationXref
id: F7G8G5
db: uniprot

Raf homolog serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q07292 959
organism: Caenorhabditis elegans

uniprot P98083 752
type: UnificationXref
id: P98083
db: uniprot

uniprot O00750 844
type: UnificationXref
id: O00750
db: uniprot

uniprot Q4KSH7 774
type: UnificationXref
id: Q4KSH7
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1
type: ProteinReference
xref: uniprot Q7ZW20 144
xref: PTHR18860:SF17
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F6S9S9 909
xref: PTHR48013:SF8
organism: Monodelphis domestica

uniprot Q8VWH2 522
type: UnificationXref
id: Q8VWH2
db: uniprot

uniprot F7BBM1 830
type: UnificationXref
id: F7BBM1
db: uniprot

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C4M5Z7 1078
organism: Entamoeba histolytica

uniprot Q9NAD6 1009
type: UnificationXref
id: Q9NAD6
db: uniprot

uniprot H2QDN0 712
type: UnificationXref
id: H2QDN0
db: uniprot

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

uniprot E9H1W5 32
type: UnificationXref
id: E9H1W5
db: uniprot

uniprot B1H230 152
type: UnificationXref
id: B1H230
db: uniprot

uniprot O88763 849
type: UnificationXref
id: O88763
db: uniprot

uniprot F1LNJ8 817
type: UnificationXref
id: F1LNJ8
db: uniprot

uniprot F7D2D3 982
type: UnificationXref
id: F7D2D3
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LTT9 1012
xref: PTHR24055:SF110
organism: Bos taurus

uniprot P29355 581
type: UnificationXref
id: P29355
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5QUZ8 224
xref: PTHR24055:SF203
organism: Macaca mulatta

Sprouty RTK-signaling antagonist 2
type: ProteinReference
xref: uniprot F1QU39 176
organism: Danio rerio

PP2A
type: ProteinReference
xref: P00547
standard name: protein phosphatase 2A
comment: ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.PP2A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: protein phosphatase 2A Synonym: Serine/threonine protein phosphatase 2A Accession: P00547
member entity reference: Serine/threonine-protein phosphatase
member entity reference: Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
member entity reference: Serine/threonine protein phosphatase 2A regulatory subunit
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
member entity reference: Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
member entity reference: Serine/threonine-protein phosphatase PP2A-5 catalytic subunit
member entity reference: Serine/threonine-protein phosphatase 6 catalytic subunit
member entity reference: Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform
member entity reference: Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform
member entity reference: Serine/threonine-protein phosphatase PP2A catalytic subunit
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
member entity reference: Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform
member entity reference: Serine/threonine-protein phosphatase PP2A
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
member entity reference: Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform
member entity reference: Serine/threonine-protein phosphatase 4 catalytic subunit
member entity reference: Serine/threonine-protein phosphatase PP2A-3 catalytic subunit
member entity reference: Well-rounded, isoform B
member entity reference: Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform
member entity reference: Serine/threonine-protein phosphatase PP2A-4 catalytic subunit
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit A
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: uniprot Q61084 733
xref: PTHR24361:SF656
organism: Mus musculus

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q61083 732
xref: PTHR24361:SF342
organism: Mus musculus

uniprot A0A1B8XW21 1072
type: UnificationXref
id: A0A1B8XW21
db: uniprot

uniprot F6W7C8 828
type: UnificationXref
id: F6W7C8
db: uniprot

14-3-3 protein gamma
type: ProteinReference
xref: uniprot P61981 93
xref: PTHR18860:SF22
organism: Homo sapiens

uniprot Q08DP7 451
type: UnificationXref
id: Q08DP7
db: uniprot

14-3-3 protein gamma
type: ProteinReference
xref: uniprot P61982 94
xref: PTHR18860:SF22
organism: Mus musculus

uniprot F7G3I5 834
type: UnificationXref
id: F7G3I5
db: uniprot

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

14-3-3 protein gamma
type: ProteinReference
xref: uniprot P61983 95
xref: PTHR18860:SF22
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot K7CXU1 428
xref: PTHR10257:SF6
organism: Pan troglodytes

PLCgamma
type: Protein
entity reference: PLCgamma
feature: ACTIVE 167
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa9 1232
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q9WTQ0 1218
organism: Rattus norvegicus

PTHR24055:SF154
type: RelationshipXref
id: PTHR24055:SF154
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot P16885 789
xref: PTHR10336:SF25
organism: Homo sapiens

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 92

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A9SKN8 392
organism: Physcomitrella patens

uniprot Q9XZE5 492
type: UnificationXref
id: Q9XZE5
db: uniprot

uniprot P01134 558
type: UnificationXref
id: P01134
db: uniprot

uniprot F6ZKB3 316
type: UnificationXref
id: F6ZKB3
db: uniprot

RAS p21 protein activator 2
type: ProteinReference
xref: PTHR10194:SF21
xref: uniprot E2QUM7 342
organism: Canis lupus familiaris

uniprot P41743 1192
type: UnificationXref
id: P41743
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Survival Apoptosis cell migration
controller: JNK1-3

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 257

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q05144 1105
organism: Mus musculus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Transcription cell cycle progression
controller: Complex (EGFR/PLC_gamma/ STAT/PI3K/ SHC/Gab/ Grb2/SOS/ GAP)

Protein sprouty homolog 4
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot Q9WTP2 193
organism: Mus musculus

uniprot H2QNH9 353
type: UnificationXref
id: H2QNH9
db: uniprot

uniprot P54675 860
type: UnificationXref
id: P54675
db: uniprot

Neuregulin 1
type: ProteinReference
xref: uniprot Q6DR99 574
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6UB42 824
organism: Macaca mulatta

ncbitaxon 284811 139
type: UnificationXref
id: 284811
db: ncbitaxon

PTHR24055:SF189
type: RelationshipXref
id: PTHR24055:SF189
db: PANTHER Family
relationship type: By Homology

SPRY
type: DnaRegion
entity reference: sprouty
cellular location: cytosol
comment: SPECIES_TYPE=GENE

uniprot F7GAP5 835
type: UnificationXref
id: F7GAP5
db: uniprot

uniprot F1P714 407
type: UnificationXref
id: F1P714
db: uniprot

uniprot F1PBB6 765
type: UnificationXref
id: F1PBB6
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 387

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BD74 157
xref: PTHR48013:SF21
organism: Monodelphis domestica

ncbitaxon 10090 71
type: UnificationXref
id: 10090
db: ncbitaxon

uniprot F6XLR8 49
type: UnificationXref
id: F6XLR8
db: uniprot

uniprot Q8K4S7 301
type: UnificationXref
id: Q8K4S7
db: uniprot

uniprot F7DY42 57
type: UnificationXref
id: F7DY42
db: uniprot

uniprot Q61831 331
type: UnificationXref
id: Q61831
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF25
xref: uniprot A0A1D5QLW6 776
organism: Macaca mulatta

Raf-1
type: Protein
entity reference: Raf-1
feature: Raf 1 s23 a26 rs4
feature: Raf 1 s23 a26 rs1
feature: Raf 1 s23 a26 rs2
feature: Raf 1 s23 a26 rs3
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__EGFR-RIGHT__EGFR-_r56
controller: c-Cbl

uniprot A5PJP8 763
type: UnificationXref
id: A5PJP8
db: uniprot

uniprot Q8WWW8 1066
type: UnificationXref
id: Q8WWW8
db: uniprot

uniprot F6XT65 910
type: UnificationXref
id: F6XT65
db: uniprot

uniprot P08556 664
type: UnificationXref
id: P08556
db: uniprot

uniprot A8Y4R8 388
type: UnificationXref
id: A8Y4R8
db: uniprot

uniprot F6TAH0 784
type: UnificationXref
id: F6TAH0
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q05513 1201
organism: Homo sapiens

uniprot Q63538 1037
type: UnificationXref
id: Q63538
db: uniprot

uniprot P40763 987
type: UnificationXref
id: P40763
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QLB4 239
xref: PTHR24055:SF203
organism: Pan troglodytes

Serine/threonine-protein kinase B-raf
type: ProteinReference
xref: uniprot Q04982 958
organism: Gallus gallus

uniprot Q61527 216
type: UnificationXref
id: Q61527
db: uniprot

14-3-3-like protein GF14-D
type: ProteinReference
xref: uniprot Q2R2W2 117
xref: PTHR18860:SF69
organism: Oryza sativa

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot A0A1D5RL09 378
organism: Macaca mulatta

GRB2-associated-binding protein 2
type: ProteinReference
xref: uniprot Q9EQH1 1067
xref: PTHR45960:SF1
organism: Rattus norvegicus

uniprot F6TNW3 44
type: UnificationXref
id: F6TNW3
db: uniprot

uniprot Q62074 1209
type: UnificationXref
id: Q62074
db: uniprot

Phosphatidylethanolamine binding protein
type: ProteinReference
xref: uniprot Q6NYS4 518
organism: Danio rerio

AGAP012252-PA (Fragment)
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot Q7Q042 1212
organism: Anopheles gambiae

uniprot A2VDZ0 382
type: UnificationXref
id: A2VDZ0
db: uniprot

uniprot J9P6N4 67
type: UnificationXref
id: J9P6N4
db: uniprot

uniprot A0A2I3TQ88 967
type: UnificationXref
id: A0A2I3TQ88
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Complex__Grb2_SOS_-_EGFR-RIGHT__Complex__EGFR_Grb2__SOS_-_r58
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1287
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1288
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 1286
left: Complex (Grb2/SOS)
left: EGFR
interaction type: HETERODIMER_ASSOCIATION
right: Complex (EGFR/Grb2/ SOS)

uniprot F6YPY3 1056
type: UnificationXref
id: F6YPY3
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: PTHR11801:SF47
xref: uniprot E2RE22 970
organism: Canis lupus familiaris

uniprot H2QDQ1 1167
type: UnificationXref
id: H2QDQ1
db: uniprot

PTHR10257:SF19
type: RelationshipXref
id: PTHR10257:SF19
db: PANTHER Family
relationship type: By Homology

ncbitaxon 3055 14
type: UnificationXref
id: 3055
db: ncbitaxon

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
type: ProteinReference
xref: uniprot Q0V9W8 114
xref: PTHR18860:SF22
organism: Xenopus tropicalis

uniprot Q8CIH5 795
type: UnificationXref
id: Q8CIH5
db: uniprot

JNK1-3
type: Protein
entity reference: JNK1-3
feature: JNK1 3 s50 a63 rs1
feature: ACTIVE 167
feature: JNK1 3 s50 a63 rs2
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P17252 1182
organism: Homo sapiens

uniprot F6YCI3 887
type: UnificationXref
id: F6YCI3
db: uniprot

Proheparin-binding EGF-like growth factor
type: ProteinReference
xref: uniprot Q06186 572
xref: PTHR10740:SF4
organism: Mus musculus

uniprot Q02384 893
type: UnificationXref
id: Q02384
db: uniprot

uniprot Q07100 450
type: UnificationXref
id: Q07100
db: uniprot

uniprot Q9GPS0 1125
type: UnificationXref
id: Q9GPS0
db: uniprot

uniprot Q9CQR6 485
type: UnificationXref
id: Q9CQR6
db: uniprot

uniprot Q54PQ4 898
type: UnificationXref
id: Q54PQ4
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q9VXH3 796
organism: Drosophila melanogaster

uniprot C4M8K6 1079
type: UnificationXref
id: C4M8K6
db: uniprot

uniprot Q9W7C5 577
type: UnificationXref
id: Q9W7C5
db: uniprot

uniprot Q6GL60 1114
type: UnificationXref
id: Q6GL60
db: uniprot

Receptor protein-tyrosine kinase
type: ProteinReference
xref: PTHR24416:SF91
xref: uniprot A0A2I3RYF9 196
organism: Pan troglodytes

uniprot Q01387 681
type: UnificationXref
id: Q01387
db: uniprot

Ras-related protein M-Ras
type: ProteinReference
xref: uniprot O14807 657
organism: Homo sapiens

STATE_TRANSITION
type: InteractionVocabulary

Serine/threonine-protein phosphatase PP2A catalytic subunit
type: ProteinReference
xref: uniprot P48580 440
organism: Neurospora crassa

uniprot F7DUD6 831
type: UnificationXref
id: F7DUD6
db: uniprot

uniprot F6XL57 416
type: UnificationXref
id: F6XL57
db: uniprot

uniprot A0A3Q1NH21 591
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q16539 1034
xref: PTHR24055:SF110
organism: Homo sapiens

uniprot H2QR74 354
type: UnificationXref
id: H2QR74
db: uniprot

Grb2 s13 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
type: ProteinReference
xref: PTHR10257:SF80
xref: uniprot Q16537 460
organism: Homo sapiens

RAS p21 protein activator 1
type: ProteinReference
xref: uniprot E9PYG6 343
xref: PTHR10194:SF19
organism: Mus musculus

ncbitaxon 7668 495
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot A0A1D5RHD1 149
type: UnificationXref
id: A0A1D5RHD1
db: uniprot

Rac1B, RHO family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot F0ZQR3 1082
organism: Dictyostelium purpureum

uniprot O44783 186
type: UnificationXref
id: O44783
db: uniprot

uniprot F1QNG4 641
type: UnificationXref
id: F1QNG4
db: uniprot

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: uniprot Q5A1D3 266
xref: PTHR24055:SF158
organism: Candida albicans

uniprot A0A1D5R6N7 377
type: UnificationXref
id: A0A1D5R6N7
db: uniprot

uniprot F7DGH9 56
type: UnificationXref
id: F7DGH9
db: uniprot

uniprot F6TA21 42
type: UnificationXref
id: F6TA21
db: uniprot

uniprot C4M5Z7 1078
type: UnificationXref
id: C4M5Z7
db: uniprot

GAB3 isoform 2
type: ProteinReference
xref: uniprot A0A2J8J4U3 1050
xref: PTHR45960:SF3
organism: Pan troglodytes

STATE_TRANSITION_LEFT__JNK1_3-RIGHT__JNK1_3-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1298
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1299
left: JNK1-3
interaction type: STATE_TRANSITION
right: JNK1-3

ncbitaxon 6945 20
type: UnificationXref
id: 6945
db: ncbitaxon

Serine/threonine-protein kinase D1
type: ProteinReference
xref: uniprot Q62101 1210
xref: PTHR22968:SF9
organism: Mus musculus

SPRY1 isoform 1
type: DnaReference
xref: PTHR12365:SF10
organism: Pan troglodytes

Rho family GTPase
type: ProteinReference
xref: uniprot C4M5T0 1077
xref: PTHR24072:SF310
organism: Entamoeba histolytica

uniprot P42229 993
type: UnificationXref
id: P42229
db: uniprot

uniprot F1QI90 292
type: UnificationXref
id: F1QI90
db: uniprot

Serine/threonine-protein kinase
type: ProteinReference
xref: uniprot H2Q845 1164
xref: PTHR22968:SF9
organism: Pan troglodytes

uniprot Q54QB1 265
type: UnificationXref
id: Q54QB1
db: uniprot

uniprot F7CKV9 1087
type: UnificationXref
id: F7CKV9
db: uniprot

ERK1-2
type: Protein
entity reference: ERK1-2
feature: ERK1 2 s27 a30 rs2
feature: ERK1 2 s27 a30 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F6ZTS0 1020
type: UnificationXref
id: F6ZTS0
db: uniprot

uniprot Q7SHZ6 872
type: UnificationXref
id: Q7SHZ6
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
type: ProteinReference
xref: PTHR10257:SF4
xref: uniprot Q6PD28 470
organism: Mus musculus

uniprot Q5ZIB8 866
type: UnificationXref
id: Q5ZIB8
db: uniprot

uniprot F6TXC2 1017
type: UnificationXref
id: F6TXC2
db: uniprot

uniprot A0A0P0V857 496
type: UnificationXref
id: A0A0P0V857
db: uniprot

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 233

uniprot Q92529 758
type: UnificationXref
id: Q92529
db: uniprot

uniprot P78759 448
type: UnificationXref
id: P78759
db: uniprot

uniprot Q5F352 689
type: UnificationXref
id: Q5F352
db: uniprot

PTHR11362:SF10
type: RelationshipXref
id: PTHR11362:SF10
db: PANTHER Family
relationship type: By Homology

uniprot Q9Z1L0 879
type: UnificationXref
id: Q9Z1L0
db: uniprot

uniprot Q0VD16 921
type: UnificationXref
id: Q0VD16
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6TNW3 44
xref: PTHR18860:SF17
organism: Ciona intestinalis

Proheparin-binding EGF-like growth factor
type: ProteinReference
xref: PTHR10740:SF4
xref: uniprot Q06175 571
organism: Rattus norvegicus

uniprot F7FRS1 648
type: UnificationXref
id: F7FRS1
db: uniprot

Signal transducer and activator of transcription
type: ProteinReference
xref: uniprot F6UMM2 977
xref: PTHR11801:SF48
organism: Macaca mulatta

uniprot H2QQ79 1059
type: UnificationXref
id: H2QQ79
db: uniprot

Protein MOTHER of FT and TFL1 homolog 2
type: ProteinReference
xref: uniprot Q9ASJ1 525
organism: Oryza sativa

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
type: ProteinReference
xref: uniprot A0A2J8MKA4 7
xref: PTHR18860:SF28
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF138
xref: uniprot Q7RWZ8 368
organism: Neurospora crassa

uniprot Q6PC73 587
type: UnificationXref
id: Q6PC73
db: uniprot

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

Cbl proto-oncogene B
type: ProteinReference
xref: PTHR23007:SF3
xref: uniprot E2RM91 290
organism: Canis lupus familiaris

Ras-related protein Rac2
type: ProteinReference
xref: uniprot P48554 1100
xref: PTHR24072:SF281
organism: Drosophila melanogaster

PIK3CG isoform 1
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot A0A2J8QY32 804
organism: Pan troglodytes

uniprot P04627 950
type: UnificationXref
id: P04627
db: uniprot

Ras guanine nucleotide exchange factor Y
type: ProteinReference
xref: uniprot Q552M5 900
organism: Dictyostelium discoideum

uniprot Q9S9Z8 148
type: UnificationXref
id: Q9S9Z8
db: uniprot

uniprot H2Q845 1164
type: UnificationXref
id: H2Q845
db: uniprot

Uncharacterized protein
type: DnaReference
xref: PTHR12365:SF6
organism: Macaca mulatta

uniprot P0CQ42 668
type: UnificationXref
id: P0CQ42
db: uniprot

uniprot F4IA59 39
type: UnificationXref
id: F4IA59
db: uniprot

uniprot Q6DR99 574
type: UnificationXref
id: Q6DR99
db: uniprot