Phosphatidylinositol 3-kinase catalytic subunit type 3
Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform
Cas-Br-M (murine) ecotropic retroviral transforming oncogene
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.c_minus_Cbl
ENTITY_REFERENCE_NOTES=Long Name: Cas-Br-M (murine) ecotropic retroviral transforming oncogene Synonym: Synonym not specified Accession: P00544
Serine/threonine protein phosphatase 2A regulatory subunit
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
Mitogen-activated protein kinase kinase 2
Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
SOS Ras/Rac guanine nucleotide exchange factor 1
Dual specificity mitogen-activated protein kinase kinase 1
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
Signal transducer and activator of transcription
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Pro-neuregulin-2, membrane-bound isoform
Dual-specificity mitogen-activated protein kinase kinase 2
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
Signal transducers and activators of transcription
ENTITY_REFERENCE_NOTES=Long Name: signal transducer and activator of transcription Synonym: Acute-phase response factor,Mammary gland factor Accession: P00561
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.STAT
Non-specific serine/threonine protein kinase
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
Mitogen-activated protein kinase kinase 3
A-Raf proto-oncogene, serine/threonine kinase
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
Mitogen-activated protein kinase kinase kinase 3
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Phosphatidylethanolamine binding protein 4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
ENTITY_REFERENCE_NOTES=Long Name: Ras Synonym: Synonym not specified Accession: P00552
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Ras
Mitogen activated protein kinase kinase 2
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.JNK1_minus_3
ENTITY_REFERENCE_NOTES=Long Name: C-jun-amino-terminal kinase 1, 2, and 3 Synonym: SAPK,stress-activated protein kinase Accession: P00545
Serine/threonine-protein kinase BCK1/SLK1/SSP31
Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
Mitogen-activated protein kinase kinase 6
Dual specificity mitogen-activated protein kinase kinase 3
Ras-related C3 botulinum toxin substrate 1
Apoptotic signal-regulating kinase 1, isoform C
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Phosphatidylethanolamine-binding protein 1
Phosphoinositide-3-kinase regulatory subunit 5
Signal transducer and activator of transcription 5B
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Dual specificity mitogen-activated protein kinase kinase hemipterous
Related RAS viral (R-ras) oncogene homolog
SHC (Src homology 2 domain containing) transforming protein 1
B-Raf proto-oncogene, serine/threonine kinase
Mitogen-activated protein kinase kinase kinase 4
Dual specificity mitogen-activated protein kinase kinase 4 and 7
ENTITY_REFERENCE_NOTES=Long Name: Dual specificity mitogen-activated protein kinase kinase 4 and 7 Synonym: MAP kinase kinase 4 and 7,MAPK/ERK kinase 4 and 7,MAPKK 4 and 7 Accession: P00555
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.MKK4,7
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1
Raf-1 proto-oncogene, serine/threonine kinase
Dual specificity mitogen-activated protein kinase kinase 4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Mitogen-activated protein kinase kinase kinase 3 isoform 1
Dual specificity mitogen-activated protein kinase kinase 7
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
Serine/threonine-protein phosphatase PP2A-4 catalytic subunit
Serine/threonine-protein phosphatase PP2A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
Mitogen-activated protein kinase kinase kinase 5
Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit
Ras-related C3 botulinum toxin substrate
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Rac
ENTITY_REFERENCE_NOTES=Long Name: Rac Synonym: Synonym not specified Accession: P00564
ENTITY_REFERENCE_NOTES=Long Name: Epidermal growth factor Synonym: gurken,transforming growth factor alpha Accession: P00549
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.EGF
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
Dual specificity mitogen-activated protein kinase kinase 2
Mitogen-activated protein kinase kinase 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Serine/threonine-protein phosphatase 6 catalytic subunit
SOS Ras/Rho guanine nucleotide exchange factor 2
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd
Signal transducer and transcription activator
Signal transducer and activator of transcription 4
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Mitogen-activated protein kinase kinase 1
RAC-gamma serine/threonine-protein kinase
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Signal transducer and activator of transcription 3
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.PLC_sub__gamma
ENTITY_REFERENCE_NOTES=Long Name: phospholipase c gamma Synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma,phosphoinositide phospholipase C Accession: P00556
Dual specificity mitogen-activated protein kinase kinase 6
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Pro-neuregulin-3, membrane-bound isoform
Receptor protein-tyrosine kinase (Fragment)
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.RECEPTOR.EGFR
ENTITY_REFERENCE_NOTES=Long Name: EGFR Synonym: Gurken receptor, Erb, Neu, neuregulin Accession: P00542
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
RAC-alpha serine/threonine-protein kinase
RAC-beta serine/threonine-protein kinase
Phosphatidylethanolamine-binding protein 4
Mitogen-activated protein kinase kinase kinase 1
ENTITY_REFERENCE_NOTES=Long Name: phosphatidylinositol 3-kinase Synonym: 5-bisphosphate 3-kinase,Phosphatidylinositol-4 Accession: P00557
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.PI3K
ENTITY_REFERENCE_NOTES=Long Name: SOS Synonym: Synonym not specified Accession: P00558
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.SOS
Ras guanine nucleotide exchange factor P
ENTITY_REFERENCE_NOTES=Long Name: Extracellular signal-regulated kinase Synonym: MAPK,Mitogen-activated protein kinase,pp42/44 Accession: P00543
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.ERK1_minus_2
Mitogen-activated protein kinase kinase kinase 2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
RAS p21 protein activator (GTPase activating protein) 1
Mitogen-activated protein kinase kinase 1 and 2
ENTITY_REFERENCE_NOTES=Long Name: MAP/ERK kinase Synonym: Dual specificity mitogen-activated protein kinase kinase Accession: P00559
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.MEK1_minus_2
RAF proto-oncogene serine/threonine-protein kinase
Complex (EGFR/PLC_gamma/ STAT/PI3K/ SHC/Gab/ Grb2/SOS/ GAP)
Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform
Pleckstrin homology-like domain family B member 2
Serine/threonine-protein phosphatase PP2A catalytic subunit
Phosphatidylinositol 3-kinase VPS34-like
Ras guanine nucleotide exchange factor K
Pleckstrin homology like domain family B member 2
ENTITY_REFERENCE_NOTES=Long Name: GAP Synonym: Synonym not specified Accession: P00546
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.GAP
Phosphoinositide 3-kinase regulatory subunit 5
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.PKC
ENTITY_REFERENCE_NOTES=Long Name: PKC Synonym: Synonym not specified Accession: P00565
Harvey rat sarcoma viral oncogene homolog
Phosphoinositide-3-kinase, regulatory subunit 5
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Proheparin-binding EGF-like growth factor
Serine/threonine-protein phosphatase PP2A-5 catalytic subunit
Pro-neuregulin-1, membrane-bound isoform
MODEL_NOTES=Panther Pathway: P00018 EGFR belongs to the human epidermal receptor (HER) family of receptor tyrosine kinases, which consists of four closely related receptors (EGFR (HER1, erbB1), HER2 (neu, erbB2), HER3 (erbB3), and HER4 (erbB4)) that mediate cellular signaling pathways involved in growth and proliferation in response to the binding of a variety of growth factor ligands. There are currently six known endogenous ligands for EGFR: EGF, transforming growth factor- (TGF-), amphiregulin, betacellulin, heparin-binding EGF (HB-EGF), and epiregulin.Upon ligand binding, the EGFR forms homo- or heterodimeric complexes (usually with HER2), which leads to activation of the receptor tyrosine kinase, via autophosphorylation. Medline=12813928 Medline=14527402 Medline=14561424 Medline=14766123 PMID: 12813928 PMID: 14527402 PMID: 14561424 PMID: 14766123
Signal transducer and activator of transcription 2
Src homology 2 domain-containing transforming protein 1
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.SHC
ENTITY_REFERENCE_NOTES=Long Name: Src homology 2 domain-containing transforming protein 1 Synonym: pp46/52/66 Accession: P00554
Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform
Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform
Phosphoinositide 3-kinase regulatory subunit 6
Dual specificity mitogen-activated protein kinase kinase mek-2
Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1
Raf homolog serine/threonine-protein kinase Raf
Dual specificity mitogen-activated protein kinase kinase 3 and 6
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.MKK3,6
ENTITY_REFERENCE_NOTES=Long Name: Dual specificity mitogen-activated protein kinase kinase 3 and 6 Synonym: MAP kinase kinase 3 and 6,MAPK/ERK kinase 3 and 6,MAPKK 3 and 6 Accession: P00540
Ras-related C3 botulinum toxin substrate 2
Mitogen-activated protein kinase kinase 4A
Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform
Signal transducer and activator of transcription 1-alpha/beta
Signal transducer and activator of transcription 5A
Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform
Signal transducer and activator of transcription 1
Signal transducer and activator of transcription 6
Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
Mitogen-activated protein kinase kinase 4
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform
Sporulation-specific mitogen-activated protein kinase SMK1
ENTITY_REFERENCE_NOTES=Long Name: Raf-1 kinase inhibitor protein Synonym: Hippocampal cholinergic stimulatory peptide precursor,PEBP,Phosphatidylethanolamine-binding protein,Terminal flower 1,neuropolypeptide h3,prostastic binding protein Accession: P00548
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.RKIP
Signal transducer and transcription activator 6
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
Mitogen-activated protein kinase SLT2/MPK1
Ras guanine nucleotide exchange factor B
Ras guanine nucleotide exchange factor A
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
ENTITY_REFERENCE_NOTES=Long Name: RAF proto-oncogene serine/threonine-protein kinase Synonym: C-Raf,MAP kinase kinase kinase,Raf-1 Accession: P00560
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Raf_minus_1
Ras guanine nucleotide exchange factor E
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Grb2
ENTITY_REFERENCE_NOTES=Long Name: Grb2 Synonym: sem-5 Accession: P00550
Serine/threonine-protein phosphatase PP2A-3 catalytic subunit
V-akt murine thymoma viral oncogene homolog 2,-like
ENTITY_REFERENCE_NOTES=Long Name: sprouty Synonym: antagonist of FGF signaling Accession: P00541
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Spry
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.14_minus_3_minus_3
ENTITY_REFERENCE_NOTES=Long Name: 14-3-3 Synonym: PAR-5,Stratifin,protein kinase C inhibitor protein-1 (KCIP-1) Accession: P00539
ENTITY_REFERENCE_NOTES=Long Name: SPRY Synonym: antagonist of FGF signaling Accession: G01511
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.GENE.GENE.SPRY
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Akt
ENTITY_REFERENCE_NOTES=Long Name: Thymoma viral proto-oncogene Synonym: PKB,RAC protein kinase,protein kinase B Accession: P00551
Phosphoinositide phospholipase C (Fragment)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
Putative mitogen-activated protein kinase
Phosphoinositide-3-kinase, regulatory subunit 6
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2
Phosphatidylethanolamine-binding protein 2
ENTITY_REFERENCE_NOTES=Long Name: GRB2-associated binding protein Synonym: growth factor receptor bound protein 2-associated binding protein Accession: P00563
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.Gab
Dual specificity mitogen-activated protein kinase kinase dSOR1
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Mitogen-activated protein kinase kinase kinase
ENTITY_REFERENCE_NOTES=Long Name: Mitogen-activated protein kinase kinase kinase Synonym: MAPK/ERK kinase kinase,MEK kinase Accession: P00553
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.MEKK1_minus_5
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Phosphatidylethanolamine-binding protein homolog F40A3.3
Cerebral cavernous malformations protein 2 homolog
Serine/threonine-protein phosphatase 2A catalytic subunit A
Pro-neuregulin-4, membrane-bound isoform
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Mitogen-activated protein kinase kinase kinase nsy-1
Cbl proto-oncogene, E3 ubiquitin protein ligase
Serine/threonine-protein phosphatase 4 catalytic subunit
Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform
ENTITY_REFERENCE_NOTES=Long Name: p38 MAP kinase Synonym: HOG,mitogen-activated protein kinase 11,mitogen-activated protein kinase 14 isoform 4 Accession: P00562
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.p38
Mitogen-activated protein kinase kinase kinase A
Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform
Raf homolog serine/threonine-protein kinase
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1
ENTITY_REFERENCE_ID_DESC=EGF receptor signaling pathway.PROTEIN.GENERIC.PP2A
ENTITY_REFERENCE_NOTES=Long Name: protein phosphatase 2A Synonym: Serine/threonine protein phosphatase 2A Accession: P00547
Phosphatidylethanolamine binding protein
Ras guanine nucleotide exchange factor Y