Ca2+
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=ION

uniprot P50146 174
type: UnificationXref
id: P50146
db: uniprot

G protein subunit alpha i3
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot H2PZK9 169
organism: Pan troglodytes

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: uniprot Q02294 157
xref: PTHR45628:SF6
organism: Rattus norvegicus

ncbitaxon 9031 80
type: UnificationXref
id: 9031
db: ncbitaxon

uniprot O14610 53
type: UnificationXref
id: O14610
db: uniprot

uniprot Q80SZ7 76
type: UnificationXref
id: Q80SZ7
db: uniprot

PARTICIPANT STOICHIOMETRY re21 269
type: Stoichiometry
physical entity: CB1/2AG complex
stoichiometric coefficient: 1.0

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F1P977 163
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY re21 268
type: Stoichiometry
physical entity: Gbetagamma complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re21 267
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

Glia c5
type: CellularLocationVocabulary
comment: Glia

uniprot Q9CXP8 77
type: UnificationXref
id: Q9CXP8
db: uniprot

Glutamate metabotropic receptor 1
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot H2QTV8 139
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 24
xref: PTHR13809:SF21
organism: Bos taurus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot E2RBE7 30
organism: Canis lupus familiaris

uniprot O43497 152
type: UnificationXref
id: O43497
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Ca2_PLUS_-_SNARE_Complex-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_re33
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 218
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 217
participant stoichiometry: PARTICIPANT STOICHIOMETRY re33 216
left: Ca2+
left: SNARE Complex
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SNARE Complex/Ca2+)

uniprot K7BA21 124
type: UnificationXref
id: K7BA21
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 93
xref: PTHR19850:SF29
organism: Macaca mulatta

uniprot P62873 104
type: UnificationXref
id: P62873
db: uniprot

Voltage-dependent T-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR10037:SF137
xref: uniprot F7GWW5 149
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re18 226
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re7
controller: G protein GTP complex

Mus musculus
type: BioSource
xref: ncbitaxon 10090 18

uniprot F6RIM7 164
type: UnificationXref
id: F6RIM7
db: uniprot

uniprot Q71SP5 22
type: UnificationXref
id: Q71SP5
db: uniprot

ncbitaxon 7955 109
type: UnificationXref
id: 7955
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re18 227
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 108
xref: PTHR19850:SF27
organism: Danio rerio

KNOWN_TRANSITION_OMITTED_LEFT__s94-RIGHT__2_AG-_re43
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 240
participant stoichiometry: PARTICIPANT STOICHIOMETRY re43 241
left: s94
interaction type: KNOWN_TRANSITION_OMITTED
right: 2-AG

uniprot O54898 153
type: UnificationXref
id: O54898
db: uniprot

uniprot F7GQC5 168
type: UnificationXref
id: F7GQC5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 110
xref: PTHR19850:SF31
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 106
xref: PTHR19850:SF27
organism: Homo sapiens

Ca2+ channel
type: Protein
entity reference: Ca2+ channel
feature: ACTIVE 135
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

mGluR
type: ProteinReference
xref: P05748
standard name: Metabotropic glutamate receptor 1/5
comment: ENTITY_REFERENCE_ID_DESC=Endogenous_cannabinoid_signaling.PROTEIN.RECEPTOR.mGluR
comment: ENTITY_REFERENCE_NOTES=Long Name: Metabotropic glutamate receptor 1/5 Synonym: mGlu5,mGluR1,mGlu1,mGluR5,GRM5,mGlu 1,mGlu 5 Accession: P05748
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Metabotropic glutamate receptor 1
member entity reference: Metabotropic glutamate receptor 1 isoform beta
member entity reference: Metabotropic glutamate receptor 5
member entity reference: Glutamate metabotropic receptor 1
member entity reference: Glutamate metabotropic receptor 5
member entity reference: Metabotropic glutamate receptor 5 isoform a
member entity reference: Uncharacterized protein

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot P62874 105
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 103
xref: PTHR19850:SF29
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 104
xref: PTHR19850:SF29
organism: Homo sapiens

uniprot Q01970 131
type: UnificationXref
id: Q01970
db: uniprot

ncbitaxon 9258 10
type: UnificationXref
id: 9258
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot P62880 107
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot H9ZA60 122
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re27 254
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re27 253
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot F6Y3N2 88
type: UnificationXref
id: F6Y3N2
db: uniprot

P05744
type: UnificationXref
id: P05744
db: PANTHER Pathway Component

P05745
type: UnificationXref
id: P05745
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY re26 255
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

GDP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re26 256
type: Stoichiometry
physical entity: Ca2+ channel
stoichiometric coefficient: 1.0

P05743
type: UnificationXref
id: P05743
db: PANTHER Pathway Component

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q01970 131
xref: PTHR10336:SF11
organism: Homo sapiens

mGluR s19 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: mGluR
stoichiometric coefficient: 1.0

uniprot Q5BJ11 108
type: UnificationXref
id: Q5BJ11
db: uniprot

uniprot A0A3Q1NGS8 82
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

P05746
type: UnificationXref
id: P05746
db: PANTHER Pathway Component

uniprot Q3KRE3 72
type: UnificationXref
id: Q3KRE3
db: uniprot

P05748
type: UnificationXref
id: P05748
db: PANTHER Pathway Component

Gnai3 protein
type: ProteinReference
xref: uniprot A9JTC8 161
xref: PTHR10218:SF230
organism: Danio rerio

uniprot F7FXA9 93
type: UnificationXref
id: F7FXA9
db: uniprot

Galpha
type: Protein
entity reference: Galpha
feature: COMPLEX PARTICIPANT BINDING FEATURE s60 sa42 197
feature: Galpha s60 sa42 rs1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 102
xref: PTHR19850:SF29
organism: Bos taurus

SNARE Complex
type: Protein
feature: SNARE Complex s84 sa64 rs1
cellular location: Synaptic vesicle br GABAergic c7
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re12 242
type: Stoichiometry
physical entity: 2-AG
stoichiometric coefficient: 1.0

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot Q61016 74
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 75
xref: PTHR13809:SF28
organism: Mus musculus

STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 222
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 221
left: PLC
interaction type: STATE_TRANSITION
right: PLC

Glutamate
type: SmallMolecule
cellular location: Synaptic vesicle br glutaminergic c6
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F6SD46 120
type: UnificationXref
id: F6SD46
db: uniprot

PARTICIPANT STOICHIOMETRY re12 243
type: Stoichiometry
physical entity: 2-AG
stoichiometric coefficient: 1.0

P05750
type: UnificationXref
id: P05750
db: PANTHER Pathway Component

P05751
type: UnificationXref
id: P05751
db: PANTHER Pathway Component

uniprot P31424 142
type: UnificationXref
id: P31424
db: uniprot

PARTICIPANT STOICHIOMETRY re23 262
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

uniprot R4GKD1 79
type: UnificationXref
id: R4GKD1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 90
xref: PTHR19850:SF31
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY re23 263
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot B2RSH2 162
type: UnificationXref
id: B2RSH2
db: uniprot

PARTICIPANT STOICHIOMETRY re23 264
type: Stoichiometry
physical entity: Complex (SNARE Complex/Ca2+)
stoichiometric coefficient: 1.0

GTP s29 sa24 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re22
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 265
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 266
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

uniprot F7G7I9 45
type: UnificationXref
id: F7G7I9
db: uniprot

PARTICIPANT STOICHIOMETRY re31 219
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

uniprot A0A2I3TFM8 160
type: UnificationXref
id: A0A2I3TFM8
db: uniprot

SNARE Complex s81 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re27
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 253
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 254
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

SNARE Complex
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s65 sa53 205
feature: ACTIVE 135
feature: SNARE Complex s65 sa53 rs1
cellular location: Synaptic vesicle br glutaminergic c6
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__CB1-_2_AG-RIGHT__CB1_2AG_complex-_re17
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 228
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 229
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 230
left: 2-AG
left: CB1
interaction type: HETERODIMER_ASSOCIATION
right: CB1/2AG complex

PARTICIPANT STOICHIOMETRY re39 272
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re39 273
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re24 260
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Metabotropic glutamate receptor 1
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot P97772 144
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re24 261
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 21

Voltage-dependent P/Q-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR10037:SF290
xref: uniprot F1N1E0 148
organism: Bos taurus

GDP s30 sa25 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 27

Metabotropic glutamate receptor 1 isoform beta
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot F7GU00 138
organism: Macaca mulatta

G protein
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s33 sa26 185
feature: ACTIVE 135
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re29 252
type: Stoichiometry
physical entity: CB1/2AG complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re31 220
type: Stoichiometry
physical entity: GABA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 250
type: Stoichiometry
physical entity: CB1
stoichiometric coefficient: 1.0

HETERODIMER_ASSOCIATION_LEFT__CB1-_anandamide-RIGHT__CB1_2AG_complex-_re29
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 252
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 251
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 250
left: anandamide
left: CB1
interaction type: HETERODIMER_ASSOCIATION
right: CB1/2AG complex

TRIGGER
type: RelationshipTypeVocabulary

G protein s33 sa26 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G protein
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re29 251
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re42 245
type: Stoichiometry
physical entity: sa69_degraded
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re42 244
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

uniprot H2Q1D9 49
type: UnificationXref
id: H2Q1D9
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F1PL90 119
organism: Canis lupus familiaris

uniprot P23385 141
type: UnificationXref
id: P23385
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 53
xref: PTHR13809:SF28
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot Q5E9F0 73
organism: Bos taurus

PLC
type: ProteinReference
xref: P05746
standard name: phospholipase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Endogenous_cannabinoid_signaling.PROTEIN.GENERIC.PLC
comment: ENTITY_REFERENCE_NOTES=Long Name: phospholipase C Synonym: Phosphoinositidase C Accession: P05746
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

uniprot F6UJE8 165
type: UnificationXref
id: F6UJE8
db: uniprot

Metabotropic glutamate receptor 1
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot P23385 141
organism: Rattus norvegicus

uniprot O00555 151
type: UnificationXref
id: O00555
db: uniprot

axon terminus
type: CellularLocationVocabulary
xref: GO GO:0043679 2

uniprot F6V461 37
type: UnificationXref
id: F6V461
db: uniprot

Metabotropic glutamate receptor 5
type: ProteinReference
xref: PTHR24060:SF30
xref: uniprot P41594 143
organism: Homo sapiens

HETERODIMER_ASSOCIATION_LEFT__SNARE_Complex-_Ca2_PLUS_-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_re23
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 264
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 262
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 263
left: Ca2+
left: SNARE Complex
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SNARE Complex/Ca2+)

uniprot O60262 55
type: UnificationXref
id: O60262
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot P11017 97
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re1 236
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 234
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 237
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 235
type: Stoichiometry
physical entity: mGluR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 232
type: Stoichiometry
physical entity: mGluR G protein complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 233
type: Stoichiometry
physical entity: G protein GTP complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 231
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot F7GWW5 149
type: UnificationXref
id: F7GWW5
db: uniprot

Synaptic vesicle br GABAergic c7
type: CellularLocationVocabulary
comment: Synaptic vesicle_br_(GABAergic)

Ca2+
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=ION

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: PTHR45628:SF3
xref: uniprot P97445 155
organism: Mus musculus

uniprot F7BB02 41
type: UnificationXref
id: F7BB02
db: uniprot

PARTICIPANT STOICHIOMETRY re20 271
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 270
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

uniprot H2QNS5 95
type: UnificationXref
id: H2QNS5
db: uniprot

Glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cannabinoid receptor 1
type: ProteinReference
xref: PTHR22750:SF47
xref: uniprot F1Q345 3
organism: Canis lupus familiaris

uniprot A0A2J8QDF6 116
type: UnificationXref
id: A0A2J8QDF6
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa25 191
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

sa69_degraded
type: PhysicalEntity
cellular location: Glia c5
comment: SPECIES_TYPE=DEGRADED

uniprot K7E376 52
type: UnificationXref
id: K7E376
db: uniprot

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QUY0 51
xref: PTHR13809:SF1
organism: Pan troglodytes

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 86
xref: PTHR19850:SF29
organism: Ornithorhynchus anatinus

ncbitaxon 10116 12
type: UnificationXref
id: 10116
db: ncbitaxon

Guanine nucleotide-binding protein G(O) subunit alpha isoform a
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot F7GQC5 168
organism: Macaca mulatta

uniprot P16520 98
type: UnificationXref
id: P16520
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot P43425 57
organism: Rattus norvegicus

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s58 sa46 201
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

2-AG
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 26
xref: PTHR13809:SF11
organism: Xenopus tropicalis

uniprot F7ES96 43
type: UnificationXref
id: F7ES96
db: uniprot

ncbitaxon 9598 21
type: UnificationXref
id: 9598
db: ncbitaxon

Ca2+ channel
type: Protein
entity reference: Ca2+ channel
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Cannabinoid receptor 1
type: ProteinReference
xref: PTHR22750:SF47
xref: uniprot Q5IS73 20
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6RIM7 164
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re43 241
type: Stoichiometry
physical entity: 2-AG
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re43 240
type: Stoichiometry
physical entity: s94
stoichiometric coefficient: 1.0

PTHR13809:SF19
type: RelationshipXref
id: PTHR13809:SF19
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot F6XWE8 39
organism: Monodelphis domestica

Gbeta s58 sa46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 85
xref: PTHR19850:SF28
organism: Canis lupus familiaris

uniprot F1N1E0 148
type: UnificationXref
id: F1N1E0
db: uniprot

uniprot P63214 66
type: UnificationXref
id: P63214
db: uniprot

PTHR13809:SF11
type: RelationshipXref
id: PTHR13809:SF11
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 29
xref: PTHR13809:SF8
organism: Canis lupus familiaris

uniprot Q5SUF7 158
type: UnificationXref
id: Q5SUF7
db: uniprot

uniprot P62872 103
type: UnificationXref
id: P62872
db: uniprot

Cannabinoid receptor 1
type: ProteinReference
xref: PTHR22750:SF47
xref: uniprot P20272 11
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re40 248
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re40 249
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

uniprot F7F580 44
type: UnificationXref
id: F7F580
db: uniprot

PARTICIPANT STOICHIOMETRY re41 246
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

MODULATION
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F6UJE8 165
organism: Monodelphis domestica

GO GO:0043679 2
type: UnificationXref
id: GO:0043679
db: GO

SNARE Complex s84 sa64 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Ca2+ channel
type: Protein
entity reference: Ca2+ channel
feature: ACTIVE 135
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Bos taurus
type: BioSource
xref: ncbitaxon 9913 25

uniprot F6YZA3 40
type: UnificationXref
id: F6YZA3
db: uniprot

PARTICIPANT STOICHIOMETRY re41 247
type: Stoichiometry
physical entity: sa70_degraded
stoichiometric coefficient: 1.0

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 23

PARTICIPANT STOICHIOMETRY re17 228
type: Stoichiometry
physical entity: CB1
stoichiometric coefficient: 1.0

00696
type: UnificationXref
id: MOD:00696
db: mod

PARTICIPANT STOICHIOMETRY re17 229
type: Stoichiometry
physical entity: 2-AG
stoichiometric coefficient: 1.0

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 10

CB1
type: Protein
entity reference: CB1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PTHR13809:SF28
type: RelationshipXref
id: PTHR13809:SF28
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot H2Q3W7 50
organism: Pan troglodytes

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re22
control type: ACTIVATION
controller: Ca2+ channel

uniprot G3X7Z2 150
type: UnificationXref
id: G3X7Z2
db: uniprot

endocannabinoid
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s77 sa61 203
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7E427 92
type: UnificationXref
id: F7E427
db: uniprot

PTHR13809:SF21
type: RelationshipXref
id: PTHR13809:SF21
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10894 128
xref: PTHR10336:SF12
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot O89040 125
organism: Rattus norvegicus

uniprot Q00975 156
type: UnificationXref
id: Q00975
db: uniprot

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s49 sa38 215
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

PTHR19850:SF27
type: RelationshipXref
id: PTHR19850:SF27
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot P30671 56
organism: Bos taurus

uniprot P10687 127
type: UnificationXref
id: P10687
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__GABA-RIGHT__GABA-_re31
control type: ACTIVATION
controller: SNARE Complex

Cannabinoid receptor 1
type: ProteinReference
xref: uniprot P47746 17
xref: PTHR22750:SF47
organism: Mus musculus

Complex (SNARE Complex/Ca2+)
type: Complex
component stoichiometry: SNARE Complex s65 sa53 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ca2 PLUS s66 sa54 STOICHIOMETRY ID COMPLEX
component: SNARE Complex
component: Ca2+
feature: COMPLEX BINDING FEATURE s64 csa8 206
feature: COMPLEX BINDING FEATURE s64 csa8 204
cellular location: Synaptic vesicle br glutaminergic c6

PTHR24060:SF30
type: RelationshipXref
id: PTHR24060:SF30
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re17 230
type: Stoichiometry
physical entity: CB1/2AG complex
stoichiometric coefficient: 1.0

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot F6T8W7 7
type: UnificationXref
id: F6T8W7
db: uniprot

KNOWN_TRANSITION_OMITTED_LEFT__s95-RIGHT__anandamide-_re44
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 239
participant stoichiometry: PARTICIPANT STOICHIOMETRY re44 238
left: s95
interaction type: KNOWN_TRANSITION_OMITTED
right: anandamide

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot Q9DC51 181
organism: Mus musculus

PTHR19850:SF29
type: RelationshipXref
id: PTHR19850:SF29
db: PANTHER Family
relationship type: By Homology

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re18
control type: INHIBITION
controller: Gbetagamma complex

PTHR19850:SF28
type: RelationshipXref
id: PTHR19850:SF28
db: PANTHER Family
relationship type: By Homology

Metabotropic glutamate receptor 5
type: ProteinReference
xref: PTHR24060:SF30
xref: uniprot P31424 142
organism: Rattus norvegicus

uniprot F1Q345 3
type: UnificationXref
id: F1Q345
db: uniprot

Ca2+ channel
type: Protein
entity reference: Ca2+ channel
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 4

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot A0A3Q1NGS8 82
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: PTHR13809:SF21
xref: uniprot P50150 58
organism: Homo sapiens

G protein subunit beta 4
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot H2QNS5 95
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 45
xref: PTHR13809:SF11
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 60
xref: PTHR13809:SF28
organism: Bos taurus

TRIGGER
type: Control
xref: TRIGGER
controlled: Depolarization
controller: Ca2+

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 59
xref: PTHR13809:SF21
organism: Mus musculus

uniprot H2QTV8 139
type: UnificationXref
id: H2QTV8
db: uniprot

uniprot F6XWE8 39
type: UnificationXref
id: F6XWE8
db: uniprot

PTHR24060:SF29
type: RelationshipXref
id: PTHR24060:SF29
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P50146 174
organism: Gallus gallus

uniprot P43425 57
type: UnificationXref
id: P43425
db: uniprot

TRANSPORT_LEFT__GABA-RIGHT__GABA-_re31
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 219
participant stoichiometry: PARTICIPANT STOICHIOMETRY re31 220
left: GABA
interaction type: TRANSPORT
right: GABA

uniprot F6VL43 166
type: UnificationXref
id: F6VL43
db: uniprot

uniprot P50153 59
type: UnificationXref
id: P50153
db: uniprot

uniprot P08754 171
type: UnificationXref
id: P08754
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 80

PARTICIPANT STOICHIOMETRY re33 218
type: Stoichiometry
physical entity: Complex (SNARE Complex/Ca2+)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 217
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re33 216
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot O89040 125
type: UnificationXref
id: O89040
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NWG3 136
xref: PTHR24060:SF30
organism: Gallus gallus

uniprot Q3ZCA7 178
type: UnificationXref
id: Q3ZCA7
db: uniprot

uniprot O55017 154
type: UnificationXref
id: O55017
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 46
xref: PTHR13809:SF11
organism: Monodelphis domestica

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot A3KGF7 117
organism: Mus musculus

anandamide
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

MODULATION
type: Control
xref: MODULATION
controlled: KNOWN_TRANSITION_OMITTED_LEFT__s94-RIGHT__2_AG-_re43
controller: PLC

uniprot E2R2S8 85
type: UnificationXref
id: E2R2S8
db: uniprot

ncbitaxon 13616 8
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot Q9HAV0 113
type: UnificationXref
id: Q9HAV0
db: uniprot

Voltage-dependent P/Q-type calcium channel subunit alpha-1A
type: ProteinReference
xref: uniprot O00555 151
xref: PTHR45628:SF3
organism: Homo sapiens

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot F6XHP0 38
type: UnificationXref
id: F6XHP0
db: uniprot

Ca2 PLUS s82 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot P50154 60
type: UnificationXref
id: P50154
db: uniprot

PTHR10218:SF302
type: RelationshipXref
id: PTHR10218:SF302
db: PANTHER Family
relationship type: By Homology

uniprot Q5IS73 20
type: UnificationXref
id: Q5IS73
db: uniprot

ACTIVE 135
type: EntityFeature
comment: Active state

ncbitaxon 9615 4
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot E1BW98 84
type: UnificationXref
id: E1BW98
db: uniprot

Metabotropic glutamate receptor 5 isoform a
type: ProteinReference
xref: PTHR24060:SF30
xref: uniprot F6SR09 137
organism: Macaca mulatta

TRANSPORT_LEFT__2_AG-RIGHT__2_AG-_re12
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 243
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 242
left: 2-AG
interaction type: TRANSPORT
right: 2-AG

PTHR19850:SF31
type: RelationshipXref
id: PTHR19850:SF31
db: PANTHER Family
relationship type: By Homology

uniprot P52287 99
type: UnificationXref
id: P52287
db: uniprot

uniprot P09471 172
type: UnificationXref
id: P09471
db: uniprot

uniprot D3ZLD6 28
type: UnificationXref
id: D3ZLD6
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Glutamate-_mGluR-RIGHT__mGluR_G_protein_complex-_re25
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 259
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 257
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 258
left: Glutamate
left: mGluR
interaction type: HETERODIMER_ASSOCIATION
right: mGluR G protein complex

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: PTHR10037:SF137
xref: uniprot O43497 152
organism: Homo sapiens

PTHR13809:SF1
type: RelationshipXref
id: PTHR13809:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P63077 64
type: UnificationXref
id: P63077
db: uniprot

PTHR13809:SF5
type: RelationshipXref
id: PTHR13809:SF5
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF11
type: RelationshipXref
id: PTHR10336:SF11
db: PANTHER Family
relationship type: By Homology

Ca2+ channel
type: ProteinReference
xref: P05750
standard name: Voltage-dependent Ca channel
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_NOTES=Long Name: Voltage-dependent Ca channel Synonym: Synonym not specified Accession: P05750
comment: ENTITY_REFERENCE_ID_DESC=Endogenous_cannabinoid_signaling.PROTEIN.ION_CHANNEL.Ca_super_2_plus__endsuper_ channel
member entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
member entity reference: Voltage-dependent P/Q-type calcium channel subunit alpha
member entity reference: Voltage-dependent T-type calcium channel subunit alpha
member entity reference: Voltage-dependent N-type calcium channel subunit alpha
member entity reference: Voltage-dependent N-type calcium channel subunit alpha-1B
member entity reference: Voltage-dependent T-type calcium channel subunit alpha-1G

PTHR10336:SF12
type: RelationshipXref
id: PTHR10336:SF12
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF10
type: RelationshipXref
id: PTHR10336:SF10
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_re24
control type: ACTIVATION
controller: Complex (SNARE Complex/Ca2+)

uniprot Q13255 145
type: UnificationXref
id: Q13255
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot P63219 71
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 70
xref: PTHR13809:SF5
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 69
xref: PTHR13809:SF5
organism: Bos taurus

Glutamate s72 sa55 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 68
xref: PTHR13809:SF11
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 87
xref: PTHR19850:SF29
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 67
xref: PTHR13809:SF11
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 66
xref: PTHR13809:SF11
organism: Bos taurus

CB1
type: ProteinReference
xref: P05743
standard name: Cannabinoid receptor 1
comment: ENTITY_REFERENCE_NOTES=Long Name: Cannabinoid receptor 1 Synonym: CNR1 Accession: P05743
comment: ENTITY_REFERENCE_ID_DESC=Endogenous_cannabinoid_signaling.PROTEIN.RECEPTOR.CB1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Cannabinoid receptor 1

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF27
xref: uniprot F6Y3N2 88
organism: Monodelphis domestica

uniprot P30671 56
type: UnificationXref
id: P30671
db: uniprot

uniprot P97772 144
type: UnificationXref
id: P97772
db: uniprot

uniprot F6ZIZ9 89
type: UnificationXref
id: F6ZIZ9
db: uniprot

TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_re24
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 261
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 260
left: Glutamate
interaction type: TRANSPORT
right: Glutamate

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot F6XHP0 38
organism: Macaca mulatta

PLC
type: Protein
entity reference: PLC
feature: ACTIVE 135
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot A0A2I3S4R3 159
organism: Pan troglodytes

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot P51432 129
xref: PTHR10336:SF11
organism: Mus musculus

Galpha s60 sa42 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot F7CXD0 91
type: UnificationXref
id: F7CXD0
db: uniprot

uniprot A4IGZ2 26
type: UnificationXref
id: A4IGZ2
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: GABA-B receptor II pathway
controller: GABA

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 44
xref: PTHR13809:SF5
organism: Macaca mulatta

G protein subunit alpha o1
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot A0A2I3TFM8 160
organism: Pan troglodytes

GTP
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot A0A2I3TUD1 81
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 77
xref: PTHR13809:SF6
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F6ZKL2 121
organism: Macaca mulatta

SNARE Complex s81 sa66 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Ggamma s59 sa44 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P59215 175
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 31
xref: PTHR13809:SF5
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot F7CXD0 91
organism: Monodelphis domestica

uniprot F1MYW8 33
type: UnificationXref
id: F1MYW8
db: uniprot

Ca2 PLUS s66 sa54 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

uniprot P61953 62
type: UnificationXref
id: P61953
db: uniprot

uniprot Q803H5 112
type: UnificationXref
id: Q803H5
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

uniprot A3KGF7 117
type: UnificationXref
id: A3KGF7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot F1MYW8 33
organism: Bos taurus

uniprot F7G3J2 94
type: UnificationXref
id: F7G3J2
db: uniprot

Galpha
type: ProteinReference
xref: P05751
standard name: Gi/o-protein, alpha subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Endogenous_cannabinoid_signaling.PROTEIN.GENERIC.G_alpha_
comment: ENTITY_REFERENCE_NOTES=Long Name: Gi/oalpha Synonym: Synonym not specified Accession: P05751
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein G(o) subunit alpha
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: G protein subunit alpha i3
member entity reference: Guanine nucleotide-binding protein G(k) subunit alpha
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
member entity reference: Guanine nucleotide-binding protein G(O) subunit alpha isoform a
member entity reference: G protein subunit alpha i1
member entity reference: Guanine nucleotide-binding protein G(K) subunit alpha
member entity reference: G protein subunit alpha o1
member entity reference: Gnai3 protein
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a

ncbitaxon 9544 23
type: UnificationXref
id: 9544
db: ncbitaxon

Metabotropic glutamate receptor 5
type: ProteinReference
xref: PTHR24060:SF30
xref: uniprot Q3UVX5 146
organism: Mus musculus

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P18872 173
organism: Mus musculus

RCA
type: EvidenceCodeVocabulary
xref: eco ECO:0000245 54

uniprot Q5E9F0 73
type: UnificationXref
id: Q5E9F0
db: uniprot

Ggamma
type: Protein
entity reference: Ggamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s59 sa44 199
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6SD46 120
xref: PTHR10336:SF12
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot F7BB02 41
organism: Macaca mulatta

ncbitaxon 9913 25
type: UnificationXref
id: 9913
db: ncbitaxon

Metabotropic glutamate receptor 1
type: ProteinReference
xref: PTHR24060:SF29
xref: uniprot Q13255 145
organism: Homo sapiens

Complex (SNARE Complex/Ca2+)
type: Complex
component stoichiometry: Ca2 PLUS s82 sa67 STOICHIOMETRY ID COMPLEX
component stoichiometry: SNARE Complex s81 sa66 STOICHIOMETRY ID COMPLEX
component: SNARE Complex
component: Ca2+
feature: COMPLEX BINDING FEATURE s80 csa9 208
feature: COMPLEX BINDING FEATURE s80 csa9 210
cellular location: Synaptic vesicle br GABAergic c7

uniprot P59215 175
type: UnificationXref
id: P59215
db: uniprot

Gnb1l protein
type: ProteinReference
xref: PTHR19850:SF29
xref: uniprot Q803H5 112
organism: Danio rerio

uniprot F6PVT7 87
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot Q9UK08 78
type: UnificationXref
id: Q9UK08
db: uniprot

uniprot F6TFY2 36
type: UnificationXref
id: F6TFY2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 49
xref: PTHR13809:SF21
organism: Pan troglodytes

PLC
type: Protein
entity reference: PLC
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 99
xref: PTHR19850:SF31
organism: Rattus norvegicus

Voltage-dependent T-type calcium channel subunit alpha
type: ProteinReference
xref: uniprot F1MR37 147
xref: PTHR45628:SF15
organism: Bos taurus

uniprot F7GU00 138
type: UnificationXref
id: F7GU00
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 72
xref: PTHR13809:SF6
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9Z1B3 134
xref: PTHR10336:SF12
organism: Mus musculus

uniprot P20272 11
type: UnificationXref
id: P20272
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot Q00722 130
organism: Homo sapiens

uniprot F7ERP8 42
type: UnificationXref
id: F7ERP8
db: uniprot

uniprot P62880 107
type: UnificationXref
id: P62880
db: uniprot

uniprot Q61017 75
type: UnificationXref
id: Q61017
db: uniprot

uniprot F1MR37 147
type: UnificationXref
id: F1MR37
db: uniprot

Galpha
type: Protein
entity reference: Galpha
feature: Galpha s61 sa36 rs1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: PTHR13809:SF8
xref: uniprot O60262 55
organism: Homo sapiens

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: uniprot Q3ZCA7 178
xref: PTHR10218:SF230
organism: Bos taurus

uniprot A0A2I3T8F7 115
type: UnificationXref
id: A0A2I3T8F7
db: uniprot

Gbeta s48 sa37 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gbeta
stoichiometric coefficient: 1.0

DISSOCIATION_LEFT__CB1_2AG_complex-RIGHT__Gbetagamma_complex-_Galpha-_re19
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 223
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 225
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 224
left: CB1/2AG complex
interaction type: DISSOCIATION
right: Galpha
right: Gbetagamma complex

uniprot E2RGI5 31
type: UnificationXref
id: E2RGI5
db: uniprot

uniprot Q7ZW82 180
type: UnificationXref
id: Q7ZW82
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 8

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

eco ECO:0000304 16
type: UnificationXref
id: ECO:0000304
db: eco

Ggamma
type: ProteinReference
xref: P05744
standard name: G-protein, gamma subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Endogenous_cannabinoid_signaling.PROTEIN.GENERIC.G_gamma_
comment: ENTITY_REFERENCE_NOTES= Long Name: Ggamma Synonym: Synonym not specified Accession: P05744
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: G protein subunit gamma 5

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF28
xref: uniprot D3ZLD6 28
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 84
xref: PTHR19850:SF28
organism: Gallus gallus

anandamide
type: SmallMolecule
cellular location: Glia c5
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Ggamma s49 sa38 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Ggamma
stoichiometric coefficient: 1.0

uniprot H2PZK9 169
type: UnificationXref
id: H2PZK9
db: uniprot

uniprot P63078 65
type: UnificationXref
id: P63078
db: uniprot

uniprot P63216 68
type: UnificationXref
id: P63216
db: uniprot

PTHR13809:SF6
type: RelationshipXref
id: PTHR13809:SF6
db: PANTHER Family
relationship type: By Homology

s95
type: PhysicalEntity
cellular location: axon terminus
comment: SPECIES_TYPE=DEGRADED

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot O55017 154
organism: Mus musculus

PTHR13809:SF8
type: RelationshipXref
id: PTHR13809:SF8
db: PANTHER Family
relationship type: By Homology

uniprot A4IFL6 24
type: UnificationXref
id: A4IFL6
db: uniprot

uniprot F7CUB0 9
type: UnificationXref
id: F7CUB0
db: uniprot

uniprot A0A2I3S4R3 159
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

uniprot Q9Z1B3 134
type: UnificationXref
id: Q9Z1B3
db: uniprot

uniprot P62874 105
type: UnificationXref
id: P62874
db: uniprot

uniprot H2QUY0 51
type: UnificationXref
id: H2QUY0
db: uniprot

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s82 sa67 211
cellular location: Synaptic vesicle br GABAergic c7
comment: SPECIES_TYPE=ION

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot B2RSH2 162
organism: Mus musculus

By Homology
type: RelationshipTypeVocabulary

Uncharacterized protein
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot F7G3J2 94
organism: Monodelphis domestica

uniprot P61954 63
type: UnificationXref
id: P61954
db: uniprot

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot P08754 171
organism: Homo sapiens

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08753 170
xref: PTHR10218:SF230
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot F6VL43 166
organism: Macaca mulatta

GABA
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

DISSOCIATION
type: InteractionVocabulary

sa70_degraded
type: PhysicalEntity
cellular location: axon terminus
comment: SPECIES_TYPE=DEGRADED

PTHR13809:SF51
type: RelationshipXref
id: PTHR13809:SF51
db: PANTHER Family
relationship type: By Homology

uniprot Q61016 74
type: UnificationXref
id: Q61016
db: uniprot

uniprot E2R2S3 29
type: UnificationXref
id: E2R2S3
db: uniprot

uniprot A9JTC8 161
type: UnificationXref
id: A9JTC8
db: uniprot

Galpha s61 sa36 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TRANSPORT_LEFT__anandamide-RIGHT__anandamide-_re40
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 248
participant stoichiometry: PARTICIPANT STOICHIOMETRY re40 249
left: anandamide
interaction type: TRANSPORT
right: anandamide

uniprot P61952 61
type: UnificationXref
id: P61952
db: uniprot

uniprot Q00722 130
type: UnificationXref
id: Q00722
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 113
xref: PTHR19850:SF28
organism: Homo sapiens

Gbeta
type: Protein
entity reference: Gbeta
feature: COMPLEX PARTICIPANT BINDING FEATURE s48 sa37 213
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

GNB4 protein
type: ProteinReference
xref: PTHR19850:SF28
xref: uniprot A5PKD6 83
organism: Bos taurus

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 15

mGluR
type: Protein
entity reference: mGluR
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

Galpha
type: Protein
entity reference: Galpha
feature: Galpha s50 sa41 rs1
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

SNARE Complex s68 sa52 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

TRANSPORT_LEFT__anandamide-RIGHT__anandamide-_re39
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 273
participant stoichiometry: PARTICIPANT STOICHIOMETRY re39 272
left: anandamide
interaction type: TRANSPORT
right: anandamide

uniprot E2RBE7 30
type: UnificationXref
id: E2RBE7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 32
xref: PTHR13809:SF11
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot A0A2I3T8F7 115
organism: Pan troglodytes

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7ZW82 180
organism: Danio rerio

endocannabinoid s77 sa61 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: endocannabinoid
stoichiometric coefficient: 1.0

Voltage-dependent N-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR10037:SF289
xref: uniprot G3X7Z2 150
organism: Bos taurus

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 48
xref: PTHR13809:SF51
organism: Pan troglodytes

Cannabinoid receptor 1
type: ProteinReference
xref: PTHR22750:SF47
xref: uniprot F7CUB0 9
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot F1PJE5 34
organism: Canis lupus familiaris

uniprot A0A1D5Q4D0 114
type: UnificationXref
id: A0A1D5Q4D0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q99JE6 132
xref: PTHR10336:SF11
organism: Rattus norvegicus

uniprot Q9NQ66 133
type: UnificationXref
id: Q9NQ66
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot Q9UK08 78
organism: Homo sapiens

Glutamate metabotropic receptor 5
type: ProteinReference
xref: uniprot J9JH96 140
xref: PTHR24060:SF30
organism: Canis lupus familiaris

PTHR45628:SF6
type: RelationshipXref
id: PTHR45628:SF6
db: PANTHER Family
relationship type: By Homology

HETERODIMER_ASSOCIATION_LEFT__Galpha-_Gbetagamma_complex-RIGHT__CB1_2AG_complex-_re21
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 267
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 269
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 268
left: Gbetagamma complex
left: Galpha
interaction type: HETERODIMER_ASSOCIATION
right: CB1/2AG complex

Voltage-dependent N-type calcium channel subunit alpha-1B
type: ProteinReference
xref: PTHR45628:SF6
xref: uniprot Q00975 156
organism: Homo sapiens

PTHR45628:SF3
type: RelationshipXref
id: PTHR45628:SF3
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re22 266
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

ncbitaxon 10090 18
type: UnificationXref
id: 10090
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re22 265
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

CB1/2AG complex
type: Complex
component stoichiometry: CB1 s45 sa34 STOICHIOMETRY ID COMPLEX
component stoichiometry: Galpha s60 sa42 STOICHIOMETRY ID COMPLEX
component stoichiometry: Gbeta s58 sa46 STOICHIOMETRY ID COMPLEX
component stoichiometry: endocannabinoid s77 sa61 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s59 sa44 STOICHIOMETRY ID COMPLEX
component: Ggamma
component: CB1
component: Galpha
component: Gbeta
component: endocannabinoid
feature: COMPLEX BINDING FEATURE s43 csa5 202
feature: COMPLEX BINDING FEATURE s43 csa5 198
feature: COMPLEX BINDING FEATURE s43 csa5 196
feature: COMPLEX BINDING FEATURE s43 csa5 200
feature: COMPLEX BINDING FEATURE s43 csa5 194
cellular location: axon terminus

uniprot P54311 100
type: UnificationXref
id: P54311
db: uniprot

uniprot J9JH96 140
type: UnificationXref
id: J9JH96
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 109

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF5
xref: uniprot R4GKD1 79
organism: Gallus gallus

PTHR22750:SF47
type: RelationshipXref
id: PTHR22750:SF47
db: PANTHER Family
relationship type: By Homology

uniprot F1PL90 119
type: UnificationXref
id: F1PL90
db: uniprot

uniprot H9ZA60 122
type: UnificationXref
id: H9ZA60
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot F7ES96 43
organism: Macaca mulatta

uniprot P50150 58
type: UnificationXref
id: P50150
db: uniprot

SNARE Complex s65 sa53 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.84
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Galpha s60 sa42 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re27
control type: ACTIVATION
controller: Ca2+ channel

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF11
xref: uniprot G3V8K2 47
organism: Rattus norvegicus

ncbitaxon 8364 27
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot P11017 97
type: UnificationXref
id: P11017
db: uniprot

Cannabinoid receptor 1
type: ProteinReference
xref: PTHR22750:SF47
xref: uniprot Q71SP5 22
organism: Macaca mulatta

SNARE Complex
type: Protein
feature: SNARE Complex s68 sa52 rs1
cellular location: Synaptic vesicle br glutaminergic c6
comment: SPECIES_TYPE=PROTEIN

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 81
xref: PTHR19850:SF27
organism: Pan troglodytes

uniprot P63215 67
type: UnificationXref
id: P63215
db: uniprot

uniprot P18872 173
type: UnificationXref
id: P18872
db: uniprot

STATE_TRANSITION_LEFT__anandamide-RIGHT__sa69_degraded-_re42
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 244
participant stoichiometry: PARTICIPANT STOICHIOMETRY re42 245
left: anandamide
interaction type: STATE_TRANSITION
right: sa69_degraded

STATE_TRANSITION_LEFT__anandamide-RIGHT__sa70_degraded-_re41
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 246
participant stoichiometry: PARTICIPANT STOICHIOMETRY re41 247
left: anandamide
interaction type: STATE_TRANSITION
right: sa70_degraded

GABA-B receptor II pathway
type: Pathway

uniprot P10894 128
type: UnificationXref
id: P10894
db: uniprot

G protein
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa15 189
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

uniprot F6SR09 137
type: UnificationXref
id: F6SR09
db: uniprot

uniprot A5PKD6 83
type: UnificationXref
id: A5PKD6
db: uniprot

STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 227
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 226
left: Ca2+ channel
interaction type: STATE_TRANSITION
right: Ca2+ channel

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot F6YZA3 40
organism: Monodelphis domestica

uniprot F6ZKL2 121
type: UnificationXref
id: F6ZKL2
db: uniprot

uniprot Q7T3D3 179
type: UnificationXref
id: Q7T3D3
db: uniprot

G protein s20 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G protein
stoichiometric coefficient: 1.0

PTHR10037:SF290
type: RelationshipXref
id: PTHR10037:SF290
db: PANTHER Family
relationship type: By Homology

Gbeta
type: ProteinReference
xref: P05745
standard name: G protein, beta subunit
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Endogenous_cannabinoid_signaling.PROTEIN.GENERIC.G_beta_
comment: ENTITY_REFERENCE_NOTES= Long Name: Gbeta Synonym: Synonym not specified Accession: P05745
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: G protein subunit beta 3
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
member entity reference: Uncharacterized protein
member entity reference: G protein subunit beta 1
member entity reference: G protein subunit beta 4
member entity reference: G protein subunit beta 2
member entity reference: Gnb1l protein
member entity reference: GNB4 protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: Gnb2 protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot A0A2J8QDF6 116
organism: Pan troglodytes

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s29 sa24 183
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

2-AG
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P21554 14
type: UnificationXref
id: P21554
db: uniprot

uniprot F7CTP1 90
type: UnificationXref
id: F7CTP1
db: uniprot

uniprot P62871 102
type: UnificationXref
id: P62871
db: uniprot

Voltage-dependent T-type calcium channel subunit alpha-1G
type: ProteinReference
xref: PTHR10037:SF137
xref: uniprot O54898 153
organism: Rattus norvegicus

G protein GTP complex
type: Complex
component stoichiometry: GTP s29 sa24 STOICHIOMETRY ID COMPLEX
component stoichiometry: G protein s33 sa26 STOICHIOMETRY ID COMPLEX
component: G protein
component: GTP
feature: COMPLEX BINDING FEATURE s32 csa3 182
feature: COMPLEX BINDING FEATURE s32 csa3 184
cellular location: axon terminus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 35
xref: PTHR13809:SF5
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

Gbetagamma complex
type: Complex
component stoichiometry: Gbeta s48 sa37 STOICHIOMETRY ID COMPLEX
component stoichiometry: Ggamma s49 sa38 STOICHIOMETRY ID COMPLEX
component: Gbeta
component: Ggamma
feature: COMPLEX BINDING FEATURE s54 csa7 212
feature: COMPLEX BINDING FEATURE s54 csa7 214
cellular location: axon terminus

uniprot F1NWG3 136
type: UnificationXref
id: F1NWG3
db: uniprot

Ca2+
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s66 sa54 207
cellular location: Synaptic vesicle br glutaminergic c6
comment: SPECIES_TYPE=ION

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63097 177
organism: Bos taurus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63096 176
organism: Homo sapiens

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 126

STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 255
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 256
left: Ca2+ channel
interaction type: STATE_TRANSITION
right: Ca2+ channel

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 16

uniprot P54313 101
type: UnificationXref
id: P54313
db: uniprot

uniprot Q3UVX5 146
type: UnificationXref
id: Q3UVX5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot P61954 63
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 52
xref: PTHR13809:SF21
organism: Monodelphis domestica

Cannabinoid receptor 1
type: ProteinReference
xref: PTHR22750:SF47
xref: uniprot P21554 14
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot P61952 61
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot J9JHK9 123
xref: PTHR10336:SF11
organism: Canis lupus familiaris

MODULATION
type: Control
xref: MODULATION
controlled: KNOWN_TRANSITION_OMITTED_LEFT__s95-RIGHT__anandamide-_re44
controller: Ca2+

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 76
xref: PTHR13809:SF5
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
type: ProteinReference
xref: PTHR13809:SF1
xref: uniprot P61953 62
organism: Mus musculus

uniprot P47746 17
type: UnificationXref
id: P47746
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 36
xref: PTHR13809:SF21
organism: Macaca mulatta

uniprot J9JHK9 123
type: UnificationXref
id: J9JHK9
db: uniprot

Glutamate
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s72 sa55 193
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot H2Q3W7 50
type: UnificationXref
id: H2Q3W7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10687 127
xref: PTHR10336:SF12
organism: Rattus norvegicus

PTHR10037:SF137
type: RelationshipXref
id: PTHR10037:SF137
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot K7BA21 124
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re44 239
type: Stoichiometry
physical entity: anandamide
stoichiometric coefficient: 1.0

Voltage-dependent T-type calcium channel subunit alpha
type: ProteinReference
xref: PTHR10037:SF137
xref: uniprot Q5SUF7 158
organism: Mus musculus

STATE_TRANSITION_LEFT__Galpha-RIGHT__Galpha-_re20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 270
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 271
left: Galpha
interaction type: STATE_TRANSITION
right: Galpha

PARTICIPANT STOICHIOMETRY re44 238
type: Stoichiometry
physical entity: s95
stoichiometric coefficient: 1.0

uniprot Q61011 110
type: UnificationXref
id: Q61011
db: uniprot

PARTICIPANT STOICHIOMETRY re7 222
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 221
type: Stoichiometry
physical entity: PLC
stoichiometric coefficient: 1.0

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 12

SNARE Complex
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s81 sa66 209
feature: ACTIVE 135
feature: SNARE Complex s81 sa66 rs1
cellular location: Synaptic vesicle br GABAergic c7
comment: SPECIES_TYPE=PROTEIN

eco ECO:0000316 19
type: UnificationXref
id: ECO:0000316
db: eco

PTHR10037:SF289
type: RelationshipXref
id: PTHR10037:SF289
db: PANTHER Family
relationship type: By Homology

uniprot P97445 155
type: UnificationXref
id: P97445
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 89
xref: PTHR19850:SF28
organism: Macaca mulatta

IDA
type: EvidenceCodeVocabulary

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

Depolarization
type: Pathway

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 65
xref: PTHR13809:SF19
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: PTHR13809:SF19
xref: uniprot P63077 64
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P09471 172
organism: Homo sapiens

eco ECO:0000305 126
type: UnificationXref
id: ECO:0000305
db: eco

uniprot Q02294 157
type: UnificationXref
id: Q02294
db: uniprot

SNARE Complex s65 sa53 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SNARE Complex
stoichiometric coefficient: 1.0

s94
type: PhysicalEntity
cellular location: axon terminus
comment: SPECIES_TYPE=DEGRADED

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

uniprot P63097 177
type: UnificationXref
id: P63097
db: uniprot

Galpha s50 sa41 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot E2RJB3 32
type: UnificationXref
id: E2RJB3
db: uniprot

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 96
xref: PTHR19850:SF31
organism: Pan troglodytes

anandamide
type: SmallMolecule
cellular location: axon terminus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 101
xref: PTHR19850:SF27
organism: Rattus norvegicus

uniprot Q9DC51 181
type: UnificationXref
id: Q9DC51
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 100
xref: PTHR19850:SF29
organism: Rattus norvegicus

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7A472 167
organism: Xenopus tropicalis

uniprot P63217 69
type: UnificationXref
id: P63217
db: uniprot

CB1 s45 sa34 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CB1
stoichiometric coefficient: 1.0

uniprot H2PZA6 48
type: UnificationXref
id: H2PZA6
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

PANTHER Pathway P05730 1
type: UnificationXref
id: P05730
db: PANTHER Pathway

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 92
xref: PTHR19850:SF28
organism: Ornithorhynchus anatinus

TRANSPORT
type: InteractionVocabulary

uniprot F7GI54 46
type: UnificationXref
id: F7GI54
db: uniprot

uniprot E2RT75 118
type: UnificationXref
id: E2RT75
db: uniprot

uniprot P63096 176
type: UnificationXref
id: P63096
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7T3D3 179
organism: Danio rerio

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 111
xref: PTHR19850:SF29
organism: Danio rerio

uniprot P41594 143
type: UnificationXref
id: P41594
db: uniprot

uniprot Q6PH57 111
type: UnificationXref
id: Q6PH57
db: uniprot

mGluR G protein complex
type: Complex
component stoichiometry: GDP s30 sa25 STOICHIOMETRY ID COMPLEX
component stoichiometry: Glutamate s72 sa55 STOICHIOMETRY ID COMPLEX
component stoichiometry: mGluR s19 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: G protein s20 sa15 STOICHIOMETRY ID COMPLEX
component: GDP
component: Glutamate
component: G protein
component: mGluR
feature: COMPLEX BINDING FEATURE s38 csa4 192
feature: COMPLEX BINDING FEATURE s38 csa4 190
feature: COMPLEX BINDING FEATURE s38 csa4 186
feature: COMPLEX BINDING FEATURE s38 csa4 188
cellular location: axon terminus

PTHR45628:SF15
type: RelationshipXref
id: PTHR45628:SF15
db: PANTHER Family
relationship type: By Homology

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A1D5Q4D0 114
xref: PTHR10336:SF11
organism: Macaca mulatta

uniprot P08753 170
type: UnificationXref
id: P08753
db: uniprot

uniprot F6PGC8 86
type: UnificationXref
id: F6PGC8
db: uniprot

uniprot H2R3A6 96
type: UnificationXref
id: H2R3A6
db: uniprot

uniprot F1P977 163
type: UnificationXref
id: F1P977
db: uniprot

eco ECO:0000245 54
type: UnificationXref
id: ECO:0000245
db: eco

uniprot P62879 106
type: UnificationXref
id: P62879
db: uniprot

anandamide
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F2Z3T8 35
type: UnificationXref
id: F2Z3T8
db: uniprot

uniprot P63219 71
type: UnificationXref
id: P63219
db: uniprot

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 19

Endogenous_cannabinoid_signaling
type: Pathway
pathway component: TRANSPORT_LEFT__anandamide-RIGHT__anandamide-_re1
pathway component: TRANSPORT_LEFT__anandamide-RIGHT__anandamide-_re40
pathway component: TRANSPORT_LEFT__2_AG-RIGHT__2_AG-_re12
pathway component: HETERODIMER_ASSOCIATION_LEFT__Ca2_PLUS_-_SNARE_Complex-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_re33
pathway component: DISSOCIATION_LEFT__CB1_2AG_complex-RIGHT__Gbetagamma_complex-_Galpha-_re19
pathway component: HETERODIMER_ASSOCIATION_LEFT__CB1-_2_AG-RIGHT__CB1_2AG_complex-_re17
pathway component: HETERODIMER_ASSOCIATION_LEFT__Galpha-_Gbetagamma_complex-RIGHT__CB1_2AG_complex-_re21
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re18
pathway component: PHYSICAL_STIMULATION
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re27
pathway component: TRIGGER
pathway component: TRANSPORT_LEFT__anandamide-RIGHT__anandamide-_re39
pathway component: HETERODIMER_ASSOCIATION_LEFT__Glutamate-_mGluR-RIGHT__mGluR_G_protein_complex-_re25
pathway component: STATE_TRANSITION_LEFT__anandamide-RIGHT__sa70_degraded-_re41
pathway component: STATE_TRANSITION_LEFT__PLC-RIGHT__PLC-_re7
pathway component: DISSOCIATION_LEFT__GTP-_mGluR_G_protein_complex-RIGHT__G_protein_GTP_complex-_GDP-_mGluR-_re16
pathway component: STATE_TRANSITION_LEFT__Ca2_PLUS__channel-RIGHT__Ca2_PLUS__channel-_re26
pathway component: TRANSPORT_LEFT__GABA-RIGHT__GABA-_re31
pathway component: STATE_TRANSITION_LEFT__anandamide-RIGHT__sa69_degraded-_re42
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__s94-RIGHT__2_AG-_re43
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__s95-RIGHT__anandamide-_re44
pathway component: TRANSPORT_LEFT__Glutamate-RIGHT__Glutamate-_re24
pathway component: HETERODIMER_ASSOCIATION_LEFT__SNARE_Complex-_Ca2_PLUS_-RIGHT__Complex__SNARE_Complex_Ca2_PLUS__-_re23
pathway component: STATE_TRANSITION_LEFT__Galpha-RIGHT__Galpha-_re20
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re22
pathway component: HETERODIMER_ASSOCIATION_LEFT__CB1-_anandamide-RIGHT__CB1_2AG_complex-_re29
xref: PANTHER Pathway P05730 1
comment: MODEL_NOTES=Panther Pathway: P05730 No pathway definition Medline=15936806 Medline=12843414 Medline=15525797 PMID: 12843414 PMID: 15525797 PMID: 15936806

uniprot G3V8K2 47
type: UnificationXref
id: G3V8K2
db: uniprot

TRANSPORT_LEFT__anandamide-RIGHT__anandamide-_re1
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 236
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 237
left: anandamide
interaction type: TRANSPORT
right: anandamide

DISSOCIATION_LEFT__GTP-_mGluR_G_protein_complex-RIGHT__G_protein_GTP_complex-_GDP-_mGluR-_re16
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 232
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 234
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 231
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 235
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 233
left: GTP
left: mGluR G protein complex
interaction type: DISSOCIATION
right: G protein GTP complex
right: GDP
right: mGluR

mGluR
type: Protein
entity reference: mGluR
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa14 187
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

CB1
type: Protein
entity reference: CB1
feature: COMPLEX PARTICIPANT BINDING FEATURE s45 sa34 195
cellular location: axon terminus
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

GABA
type: SmallMolecule
cellular location: Synaptic vesicle br GABAergic c7
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7A472 167
type: UnificationXref
id: F7A472
db: uniprot

uniprot P63218 70
type: UnificationXref
id: P63218
db: uniprot

Synaptic vesicle br glutaminergic c6
type: CellularLocationVocabulary
comment: Synaptic vesicle_br_(glutaminergic)

uniprot F1PJE5 34
type: UnificationXref
id: F1PJE5
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot E2RT75 118
organism: Canis lupus familiaris

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 42
xref: PTHR13809:SF5
organism: Ornithorhynchus anatinus

Cannabinoid receptor 1
type: ProteinReference
xref: uniprot F6T8W7 7
xref: PTHR22750:SF47
organism: Monodelphis domestica

uniprot Q99JE6 132
type: UnificationXref
id: Q99JE6
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 37
xref: PTHR13809:SF8
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: PTHR19850:SF31
xref: uniprot P16520 98
organism: Homo sapiens

uniprot P51432 129
type: UnificationXref
id: P51432
db: uniprot

PARTICIPANT STOICHIOMETRY re19 223
type: Stoichiometry
physical entity: CB1/2AG complex
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re19 224
type: Stoichiometry
physical entity: Gbetagamma complex
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9NQ66 133
xref: PTHR10336:SF12
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re19 225
type: Stoichiometry
physical entity: Galpha
stoichiometric coefficient: 1.0

ncbitaxon 9606 15
type: UnificationXref
id: 9606
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re25 257
type: Stoichiometry
physical entity: Glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 258
type: Stoichiometry
physical entity: mGluR
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re25 259
type: Stoichiometry
physical entity: mGluR G protein complex
stoichiometric coefficient: 1.0