PARTICIPANT STOICHIOMETRY re11 715
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PTHR24356:SF303
type: RelationshipXref
id: PTHR24356:SF303
db: PANTHER Family
relationship type: By Homology

uniprot Q63932 373
type: UnificationXref
id: Q63932
db: uniprot

PARTICIPANT STOICHIOMETRY re11 714
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P07278 293
organism: Saccharomyces cerevisiae

HETERODIMER_ASSOCIATION_LEFT__Complex__ET_RA_B_endsub_Gs_-_ET1_4-RIGHT__Complex__ET_RA_B_endsub_ET1_4_-_Gs-_re5
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 688
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 690
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 687
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 689
left: Complex (ET-RA/B_endsub/Gs)
left: ET1-4
interaction type: HETERODIMER_ASSOCIATION
right: Complex (ET-RA/B_endsub/ET1-4)
right: Gs

Adenylate cyclase type 3
type: ProteinReference
xref: PTHR45627:SF13
xref: uniprot Q8VHH7 247
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A452DI16 559
organism: Bos taurus

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__Guanylate_cyclase-RIGHT__Guanylate_cyclase-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 682
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 681
left: Guanylate cyclase
interaction type: STATE_TRANSITION
right: Guanylate cyclase

uniprot P38409 545
type: UnificationXref
id: P38409
db: uniprot

uniprot Q6NW93 331
type: UnificationXref
id: Q6NW93
db: uniprot

uniprot F6VIX5 429
type: UnificationXref
id: F6VIX5
db: uniprot

uniprot B8JLJ7 530
type: UnificationXref
id: B8JLJ7
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q08462 235
xref: PTHR45627:SF6
organism: Homo sapiens

uniprot F1MFR6 405
type: UnificationXref
id: F1MFR6
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 48

uniprot Q9DGM2 443
type: UnificationXref
id: Q9DGM2
db: uniprot

uniprot Q9WVI4 464
type: UnificationXref
id: Q9WVI4
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P28482 44
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re3 699
type: Stoichiometry
physical entity: AA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 697
type: Stoichiometry
physical entity: GPL
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re3 698
type: Stoichiometry
physical entity: LPL
stoichiometric coefficient: 1.0

uniprot G7MVY8 407
type: UnificationXref
id: G7MVY8
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q5RKP9 550
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F1PXS7 21
organism: Canis lupus familiaris

Guanylate cyclase soluble subunit alpha-1
type: ProteinReference
xref: uniprot Q9ERL9 463
organism: Mus musculus

Ca2+
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

uniprot H2QLB4 30
type: UnificationXref
id: H2QLB4
db: uniprot

uniprot D4A4U1 506
type: UnificationXref
id: D4A4U1
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot A0A2I3SK46 178
xref: PTHR45627:SF1
organism: Pan troglodytes

ECE1 isoform 4
type: ProteinReference
xref: uniprot A0A2I3TMR3 503
xref: PTHR11733:SF130
organism: Pan troglodytes

PTHR10218:SF316
type: RelationshipXref
id: PTHR10218:SF316
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P27361 40
organism: Homo sapiens

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: uniprot Q01970 660
xref: PTHR10336:SF11
organism: Homo sapiens

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
type: ProteinReference
xref: uniprot Q63803 497
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__AA-RIGHT__PGI2-_re20
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 740
participant stoichiometry: PARTICIPANT STOICHIOMETRY re20 739
left: AA
interaction type: STATE_TRANSITION
right: PGI2

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 75

PRKAR1A isoform 12
type: ProteinReference
xref: uniprot H2R3M7 283
xref: PTHR11635:SF129
organism: Pan troglodytes

PTHR10218:SF320
type: RelationshipXref
id: PTHR10218:SF320
db: PANTHER Family
relationship type: By Homology

uniprot Q19266 163
type: UnificationXref
id: Q19266
db: uniprot

STATE_TRANSITION_LEFT__PKG-RIGHT__PKG-_re9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 678
participant stoichiometry: PARTICIPANT STOICHIOMETRY re9 677
left: PKG
interaction type: STATE_TRANSITION
right: PKG

uniprot H2QAS6 128
type: UnificationXref
id: H2QAS6
db: uniprot

PTHR10218:SF328
type: RelationshipXref
id: PTHR10218:SF328
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q01986 366
organism: Rattus norvegicus

PTHR10218:SF329
type: RelationshipXref
id: PTHR10218:SF329
db: PANTHER Family
relationship type: By Homology

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re11
control type: ACTIVATION
controller: cAMP

PTHR24356:SF347
type: RelationshipXref
id: PTHR24356:SF347
db: PANTHER Family
relationship type: By Homology

uniprot Q5PU49 165
type: UnificationXref
id: Q5PU49
db: uniprot

uniprot E2RSE6 404
type: UnificationXref
id: E2RSE6
db: uniprot

PARTICIPANT STOICHIOMETRY re7 682
type: Stoichiometry
physical entity: Guanylate cyclase
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 681
type: Stoichiometry
physical entity: Guanylate cyclase
stoichiometric coefficient: 1.0

uniprot Q9VA14 253
type: UnificationXref
id: Q9VA14
db: uniprot

uniprot F1MX21 611
type: UnificationXref
id: F1MX21
db: uniprot

cGMP-dependent protein kinase egl-4
type: ProteinReference
xref: uniprot O76360 87
xref: PTHR24353:SF111
organism: Caenorhabditis elegans

uniprot A0A2R8Q8R8 79
type: UnificationXref
id: A0A2R8Q8R8
db: uniprot

NSCC
type: Protein
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O76360 87
type: UnificationXref
id: O76360
db: uniprot

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

ADCY9 isoform 1
type: ProteinReference
xref: uniprot K7CYN2 207
xref: PTHR45627:SF8
organism: Pan troglodytes

Protein kinase C-like 1B
type: ProteinReference
xref: uniprot P34885 148
xref: PTHR24356:SF240
organism: Caenorhabditis elegans

Adenylate cyclase type 4
type: ProteinReference
xref: uniprot Q91WF3 248
xref: PTHR45627:SF10
organism: Mus musculus

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__Guanylate_cyclase-RIGHT__Guanylate_cyclase-_re7
controller: NO

Protein CBR-ITR-1, isoform a
type: ProteinReference
xref: uniprot H8WGV2 620
xref: PTHR13715:SF87
organism: Caenorhabditis briggsae

uniprot P05131 290
type: UnificationXref
id: P05131
db: uniprot

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot F1NYZ2 358
xref: PTHR48013:SF8
organism: Gallus gallus

?
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot G5EGU1 537
type: UnificationXref
id: G5EGU1
db: uniprot

PKG
type: ProteinReference
xref: P00567
standard name: protein kinase, cGMP-dependent
comment: ENTITY_REFERENCE_NOTES=Long Name: protein kinase cSynonym: Synonym not specifiedAccession: P00568
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PKG
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: cGMP-dependent protein kinase 1
member entity reference: cGMP-dependent protein kinase egl-4
member entity reference: cGMP-dependent protein kinase
member entity reference: cGMP-dependent protein kinase 2
member entity reference: Protein Kinase, cGMP-dependent
member entity reference: AGAP008863-PA
member entity reference: cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B
member entity reference: Uncharacterized protein
member entity reference: cGMP-dependent protein kinase, isozyme 1

uniprot F6VVA6 645
type: UnificationXref
id: F6VVA6
db: uniprot

uniprot P17322 348
type: UnificationXref
id: P17322
db: uniprot

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot A0A2I3TRC4 529
organism: Pan troglodytes

ncbitaxon 8364 27
type: UnificationXref
id: 8364
db: ncbitaxon

Adenylate cyclase
type: ProteinReference
xref: uniprot H2Q832 203
xref: PTHR45627:SF10
organism: Pan troglodytes

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q5Z859 60
organism: Oryza sativa

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: uniprot Q9QW07 666
xref: PTHR10336:SF106
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E7EXT6 581
xref: PTHR24356:SF190
organism: Danio rerio

eco ECO:0000305 462
type: UnificationXref
id: ECO:0000305
db: eco

uniprot E1BHU9 184
type: UnificationXref
id: E1BHU9
db: uniprot

TRUNCATION_LEFT__Pro_ET1_4-RIGHT__?-_Big_ET1_4-_re28
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 722
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 721
participant stoichiometry: PARTICIPANT STOICHIOMETRY re28 723
left: Pro ET1-4
interaction type: TRUNCATION
right: Big ET1-4
right: ?

ncbitaxon 237631 5
type: UnificationXref
id: 237631
db: ncbitaxon

uniprot A0A1D5QUZ8 11
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

Signal peptidase I
type: ProteinReference
xref: uniprot Q9LW08 390
xref: PTHR10806:SF27
organism: Arabidopsis thaliana

uniprot P29993 623
type: UnificationXref
id: P29993
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 586
organism: Monodelphis domestica

MEK
type: Protein
entity reference: MEK
feature: MEK s73 sa48 rs1
feature: ACTIVE 76
feature: MEK s73 sa48 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
type: ProteinReference
xref: uniprot F1QEC8 270
xref: PTHR11635:SF129
organism: Danio rerio

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot E2RL20 561
organism: Canis lupus familiaris

GUCY1A2 isoform 2
type: ProteinReference
xref: uniprot A0A2I3SBY3 446
organism: Pan troglodytes

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 61
organism: Mus musculus

uniprot P21279 541
type: UnificationXref
id: P21279
db: uniprot

Guanine nucleotide-binding protein G(olf) subunit alpha
type: ProteinReference
xref: uniprot Q8CGK7 500
organism: Mus musculus

uniprot A8WWD7 357
type: UnificationXref
id: A8WWD7
db: uniprot

uniprot O95622 214
type: UnificationXref
id: O95622
db: uniprot

uniprot Q01970 660
type: UnificationXref
id: Q01970
db: uniprot

uniprot Q8IRF5 245
type: UnificationXref
id: Q8IRF5
db: uniprot

uniprot Q29450 239
type: UnificationXref
id: Q29450
db: uniprot

PI3 K
type: Protein
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q28FH0 547
type: UnificationXref
id: Q28FH0
db: uniprot

Mitogen-activated protein kinase FUS3
type: ProteinReference
xref: uniprot P16892 37
xref: PTHR24055:SF158
organism: Saccharomyces cerevisiae

uniprot P0C605 89
type: UnificationXref
id: P0C605
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot A0A2I3SSC7 606
xref: PTHR13715:SF52
organism: Pan troglodytes

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot F7BCI5 196
organism: Monodelphis domestica

Akt
type: Protein
entity reference: Akt
feature: Akt s79 sa24 rs1
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

AGAP003000-PA
type: ProteinReference
xref: uniprot Q7PGR0 240
organism: Anopheles gambiae

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q39024 55
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q39027 57
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q39026 56
organism: Arabidopsis thaliana

MODULATION
type: RelationshipTypeVocabulary

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q39021 52
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY re6 683
type: Stoichiometry
physical entity: PI3 K
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: vaso-relaxation
controller: PKG

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q39023 54
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY re6 684
type: Stoichiometry
physical entity: PI3 K
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase 2
type: ProteinReference
xref: uniprot Q39022 53
organism: Arabidopsis thaliana

Protein kinase C iota type
type: ProteinReference
xref: uniprot Q62074 166
xref: PTHR24356:SF214
organism: Mus musculus

cPLA2
type: ProteinReference
xref: P00583
standard name: Cytosolic phospholipase A2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cytosolic phospholipase A2Synonym: Lysophospholipase,Phosphatidylcholine 2-acylhydrolaseAccession: P00583
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.cPLA_sub_2
member entity reference: Cytosolic phospholipase A2
member entity reference: Phospholipase A2

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot Q9JID2 552
organism: Rattus norvegicus

00696
type: UnificationXref
id: MOD:00696
db: mod

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: uniprot Q6DBV8 330
xref: PTHR24353:SF135
organism: Danio rerio

PTHR10336:SF106
type: RelationshipXref
id: PTHR10336:SF106
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot H2RA86 32
organism: Pan troglodytes

PANTHER Pathway P00019 1
type: UnificationXref
id: P00019
db: PANTHER Pathway

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: PTHR10806:SF6
xref: uniprot P15367 383
organism: Saccharomyces cerevisiae

Big ET1-4
type: ProteinReference
xref: P00574
standard name: Big endothelin 1, 2, 3, and 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Big endothelin 1, 2, 3, and 4Synonym: Synonym not specifiedAccession: P00574
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Big_br_ET1_minus_4
member entity reference: Endothelin-2
member entity reference: Endothelin-3
member entity reference: EDN2 isoform 1
member entity reference: Endothelin 1
member entity reference: Endothelin-1
member entity reference: Uncharacterized protein
member entity reference: EDN1 isoform 1
member entity reference: EDN3 isoform 1

uniprot P17612 303
type: UnificationXref
id: P17612
db: uniprot

TRUNCATION_LEFT__Big_ET1_4-RIGHT__ET1_4-_?-_re29
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 720
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 719
participant stoichiometry: PARTICIPANT STOICHIOMETRY re29 718
left: Big ET1-4
interaction type: TRUNCATION
right: ET1-4
right: ?

uniprot P12367 295
type: UnificationXref
id: P12367
db: uniprot

DISSOCIATION
type: RelationshipTypeVocabulary

uniprot Q03343 233
type: UnificationXref
id: Q03343
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q9VW60 259
organism: Drosophila melanogaster

PI3 K
type: Protein
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot K7CBH8 131
xref: PTHR24356:SF159
organism: Pan troglodytes

uniprot A0A1D5R9U8 553
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

uniprot Q9Z286 263
type: UnificationXref
id: Q9Z286
db: uniprot

uniprot P16912 302
type: UnificationXref
id: P16912
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: vaso-relaxation
controller: PGI2

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

PKA
type: Protein
entity reference: PKA
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: PTHR10806:SF12
xref: uniprot A0A1D5RIY6 377
organism: Macaca mulatta

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P50148 546
organism: Homo sapiens

uniprot P29120 415
type: UnificationXref
id: P29120
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M3D6 489
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot F6XT65 360
organism: Monodelphis domestica

uniprot Q9XWB7 667
type: UnificationXref
id: Q9XWB7
db: uniprot

Gq
type: ProteinReference
xref: P00586
standard name: guanine nucleotide binding protein q polypeptide
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.G_sub_q
comment: ENTITY_REFERENCE_NOTES=Long Name: guanine nucleotide binding protein q polypeptideSynonym: G-protein qAccession: P00586
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: Guanine nucleotide-binding protein (G protein), q polypeptide
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11b (Gq class)
member entity reference: Guanine nucleotide-binding protein subunit alpha-11
member entity reference: G protein subunit alpha q
member entity reference: Guanine nucleotide-binding protein G(q) subunit alpha
member entity reference: Guanine nucleotide-binding protein subunit alpha-14
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 14
member entity reference: EGL-30
member entity reference: G protein subunit alpha 14
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)

Raf-1
type: ProteinReference
xref: P00587
standard name: RAF proto-oncogene serine/threonine-protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Raf_minus_1
comment: ENTITY_REFERENCE_NOTES=Long Name: serine/threonine Raf-1 protein kinaseSynonym: MAP kinase kinase kinase,c-RafAccession: P00587
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: Raf homolog serine/threonine-protein kinase Raf
member entity reference: Uncharacterized protein
member entity reference: Raf homolog serine/threonine-protein kinase
member entity reference: A-Raf proto-oncogene, serine/threonine kinase

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot Q01386 319
organism: Neurospora crassa

uniprot A0A2I3SBY3 446
type: UnificationXref
id: A0A2I3SBY3
db: uniprot

eco ECO:0000353 273
type: UnificationXref
id: ECO:0000353
db: eco

Adenylate cyclase
type: Protein
entity reference: Adenylate cyclase
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9GNR4 340
type: UnificationXref
id: Q9GNR4
db: uniprot

PARTICIPANT STOICHIOMETRY re2 703
type: Stoichiometry
physical entity: L-Cit
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 702
type: Stoichiometry
physical entity: L-Arg
stoichiometric coefficient: 1.0

cGMP-dependent protein kinase
type: ProteinReference
xref: uniprot F6YKH9 81
xref: PTHR24353:SF24
organism: Monodelphis domestica

Serine/threonine-protein kinase akt-2
type: ProteinReference
xref: uniprot Q9XTG7 604
xref: PTHR24356:SF333
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY re2 704
type: Stoichiometry
physical entity: NO
stoichiometric coefficient: 1.0

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot P63239 417
organism: Mus musculus

uniprot F1M7Y5 113
type: UnificationXref
id: F1M7Y5
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P27791 307
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot A3KGF7 638
xref: PTHR10336:SF10
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot A0A3Q2U0G2 637
organism: Gallus gallus

Adenylate cyclase
type: ProteinReference
xref: uniprot K7ADQ0 206
xref: PTHR45627:SF9
organism: Pan troglodytes

uniprot O74323 380
type: UnificationXref
id: O74323
db: uniprot

ncbitaxon 321614 23
type: UnificationXref
id: 321614
db: ncbitaxon

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Adenylate cyclase
type: Protein
entity reference: Adenylate cyclase
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P13217 656
type: UnificationXref
id: P13217
db: uniprot

uniprot P00514 287
type: UnificationXref
id: P00514
db: uniprot

ACXD, isoform A
type: ProteinReference
xref: uniprot Q9W038 262
organism: Drosophila melanogaster

Uncharacterized protein, isoform C
type: ProteinReference
xref: uniprot Q9W037 261
organism: Drosophila melanogaster

FURIN isoform 1
type: ProteinReference
xref: uniprot H2QA34 408
xref: PTHR42884:SF1
organism: Pan troglodytes

EDN3 isoform 1
type: ProteinReference
xref: uniprot A0A2J8KMQ0 395
xref: PTHR13874:SF11
organism: Pan troglodytes

uniprot E2RGU7 111
type: UnificationXref
id: E2RGU7
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot F1MY82 115
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot A0A3Q2U4X3 579
organism: Gallus gallus

PTHR11733:SF195
type: RelationshipXref
id: PTHR11733:SF195
db: PANTHER Family
relationship type: By Homology

Prkar1a protein
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q5I0F6 326
organism: Danio rerio

uniprot Q02111 156
type: UnificationXref
id: Q02111
db: uniprot

Gs
type: Protein
entity reference: Gs
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa67 672
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6Q9S4 272
type: UnificationXref
id: F6Q9S4
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot H2QDQ1 129
xref: PTHR24356:SF193
organism: Pan troglodytes

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

uniprot P09217 138
type: UnificationXref
id: P09217
db: uniprot

Endothelin-3
type: ProteinReference
xref: uniprot P13207 399
xref: PTHR13874:SF11
organism: Rattus norvegicus

ECEL1 isoform 1
type: ProteinReference
xref: uniprot A0A2I3RJ55 502
xref: PTHR11733:SF195
organism: Pan troglodytes

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q503 271
organism: Macaca mulatta

uniprot Q39024 55
type: UnificationXref
id: Q39024
db: uniprot

uniprot P22387 350
type: UnificationXref
id: P22387
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11903:SF8
xref: uniprot F7BWZ9 465
organism: Macaca mulatta

ncbitaxon 10116 39
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot H9ZA60 650
type: UnificationXref
id: H9ZA60
db: uniprot

uniprot P38408 544
type: UnificationXref
id: P38408
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BS74 490
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY re15 706
type: Stoichiometry
physical entity: IP3 R
stoichiometric coefficient: 1.0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot P13217 656
xref: PTHR10336:SF106
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re15 705
type: Stoichiometry
physical entity: IP3 R
stoichiometric coefficient: 1.0

Protein kinase A regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot Q385V6 322
organism: Trypanosoma brucei

Raf 1 s72 sa34 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot Q9WTQ0 174
type: UnificationXref
id: Q9WTQ0
db: uniprot

uniprot P19686 453
type: UnificationXref
id: P19686
db: uniprot

uniprot P42892 517
type: UnificationXref
id: P42892
db: uniprot

uniprot A3KGF7 638
type: UnificationXref
id: A3KGF7
db: uniprot

PTHR13874:SF10
type: RelationshipXref
id: PTHR13874:SF10
db: PANTHER Family
relationship type: By Homology

Adenylate cyclase, germination specific
type: ProteinReference
xref: PTHR11920:SF487
xref: uniprot Q03101 231
organism: Dictyostelium discoideum

PTHR13874:SF11
type: RelationshipXref
id: PTHR13874:SF11
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6ZKL2 646
xref: PTHR10336:SF12
organism: Macaca mulatta

Adenylate cyclase type 10
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot Q9Z286 263
organism: Rattus norvegicus

Adenylate cyclase type 1
type: ProteinReference
xref: PTHR45627:SF12
xref: uniprot O88444 213
organism: Mus musculus

Endothelin receptor B subtype 2
type: ProteinReference
xref: uniprot F7A767 430
organism: Xenopus tropicalis

uniprot P31321 310
type: UnificationXref
id: P31321
db: uniprot

Nitric oxide synthase, endothelial
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot P70313 424
organism: Mus musculus

uniprot Q9ERL9 463
type: UnificationXref
id: Q9ERL9
db: uniprot

Raf 1 s72 sa34 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot F7EI48 28
organism: Monodelphis domestica

uniprot Q84UI5 68
type: UnificationXref
id: Q84UI5
db: uniprot

Endothelin-1
type: ProteinReference
xref: uniprot P13206 347
organism: Canis lupus familiaris

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 477
xref: uniprot A4IFJ5 476
xref: PTHR10728:SF13
organism: Bos taurus

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re14
controller: DAG

uniprot G3X7B5 591
type: UnificationXref
id: G3X7B5
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF190
xref: uniprot F7GEK1 590
organism: Monodelphis domestica

uniprot Q9DBC7 339
type: UnificationXref
id: Q9DBC7
db: uniprot

uniprot F6Y448 80
type: UnificationXref
id: F6Y448
db: uniprot

PTHR10806:SF6
type: RelationshipXref
id: PTHR10806:SF6
db: PANTHER Family
relationship type: By Homology

uniprot P00516 88
type: UnificationXref
id: P00516
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot W4YRI6 342
xref: PTHR11635:SF162
organism: Strongylocentrotus purpuratus

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 13

AGAP006475-PA
type: ProteinReference
xref: uniprot Q5TQX0 630
xref: PTHR13715:SF87
organism: Anopheles gambiae

uniprot E1B9K3 183
type: UnificationXref
id: E1B9K3
db: uniprot

uniprot A8WWE1 379
type: UnificationXref
id: A8WWE1
db: uniprot

uniprot O89040 653
type: UnificationXref
id: O89040
db: uniprot

uniprot P38405 495
type: UnificationXref
id: P38405
db: uniprot

cGMP-dependent protein kinase
type: ProteinReference
xref: PTHR24353:SF68
xref: uniprot F7G3L7 82
organism: Macaca mulatta

uniprot Q7QKC3 241
type: UnificationXref
id: Q7QKC3
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot F6SD46 643
organism: Monodelphis domestica

uniprot F1MY82 115
type: UnificationXref
id: F1MY82
db: uniprot

uniprot Q08BT6 162
type: UnificationXref
id: Q08BT6
db: uniprot

uniprot P84309 226
type: UnificationXref
id: P84309
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha 11 (Gq class)
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F6THW2 532
organism: Xenopus tropicalis

Endothelin receptor type A
type: ProteinReference
xref: uniprot F6VIX5 429
organism: Ornithorhynchus anatinus

Complex (ET-RA/B_endsub/Gs)
type: Complex
component stoichiometry: Gs s2 sa67 STOICHIOMETRY ID COMPLEX
component stoichiometry: ET RA B s1 sa66 STOICHIOMETRY ID COMPLEX
component: Gs
component: ET-RA/B
feature: COMPLEX BINDING FEATURE s57 csa1 671
feature: COMPLEX BINDING FEATURE s57 csa1 669
cellular location: cytoplasm

STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_re17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 695
participant stoichiometry: PARTICIPANT STOICHIOMETRY re17 696
left: ERK
interaction type: STATE_TRANSITION
right: ERK

uniprot Q8UUX0 602
type: UnificationXref
id: Q8UUX0
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 10

uniprot P70227 626
type: UnificationXref
id: P70227
db: uniprot

uniprot A0A1D5QMQ7 176
type: UnificationXref
id: A0A1D5QMQ7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot Q9Z1B3 668
xref: PTHR10336:SF12
organism: Mus musculus

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot P00514 287
xref: PTHR11635:SF129
organism: Bos taurus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P00515 288
organism: Bos taurus

cGMP-dependent protein kinase 1
type: ProteinReference
xref: uniprot P00516 88
xref: PTHR24353:SF68
organism: Bos taurus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P00517 289
organism: Bos taurus

uniprot P97490 227
type: UnificationXref
id: P97490
db: uniprot

uniprot K7ADQ0 206
type: UnificationXref
id: K7ADQ0
db: uniprot

uniprot P0DPD9 515
type: UnificationXref
id: P0DPD9
db: uniprot

uniprot Q9VK51 255
type: UnificationXref
id: Q9VK51
db: uniprot

Endothelin-1
type: ProteinReference
xref: PTHR13874:SF10
xref: uniprot P05305 346
organism: Homo sapiens

uniprot P27361 40
type: UnificationXref
id: P27361
db: uniprot

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 25

uniprot Q9W037 261
type: UnificationXref
id: Q9W037
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E689 450
organism: Macaca mulatta

uniprot E2QX69 403
type: UnificationXref
id: E2QX69
db: uniprot

uniprot P63239 417
type: UnificationXref
id: P63239
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot P05987 292
xref: PTHR11635:SF152
organism: Dictyostelium discoideum

uniprot A0A1D5QKD3 355
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot E2RGU7 111
organism: Canis lupus familiaris

uniprot P42893 518
type: UnificationXref
id: P42893
db: uniprot

uniprot P41743 151
type: UnificationXref
id: P41743
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RDW0 493
organism: Pan troglodytes

uniprot Q1EC10 238
type: UnificationXref
id: Q1EC10
db: uniprot

uniprot F7BYI4 122
type: UnificationXref
id: F7BYI4
db: uniprot

GTP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F1P3G1 116
type: UnificationXref
id: F1P3G1
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot F6R543 613
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re21 737
type: Stoichiometry
physical entity: PLCbeta
stoichiometric coefficient: 1.0

AGAP004940-PA
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot Q7PPI8 333
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY re21 738
type: Stoichiometry
physical entity: PLCbeta
stoichiometric coefficient: 1.0

PTHR10728:SF13
type: RelationshipXref
id: PTHR10728:SF13
db: PANTHER Family
relationship type: By Homology

PLCbeta
type: ProteinReference
xref: P00591
standard name: Phospholipase C beta
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: PLCbetaSynonym: Synonym not specifiedAccession: P00591
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PLC_sub__beta_
member entity reference: Phosphoinositide phospholipase C (Fragment)
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
member entity reference: Phosphoinositide phospholipase C
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II

NEPrilysin metallopeptidase family
type: ProteinReference
xref: uniprot O16652 511
organism: Caenorhabditis elegans

PARTICIPANT STOICHIOMETRY re8 680
type: Stoichiometry
physical entity: cGMP
stoichiometric coefficient: 1.0

uniprot A0A1D5R985 100
type: UnificationXref
id: A0A1D5R985
db: uniprot

ncbitaxon 9258 195
type: UnificationXref
id: 9258
db: ncbitaxon

Inositol 1,4,5-trisphosphate receptor itr-1
type: ProteinReference
xref: uniprot Q9Y0A1 632
xref: PTHR13715:SF87
organism: Caenorhabditis elegans

uniprot Q7T2C5 171
type: UnificationXref
id: Q7T2C5
db: uniprot

uniprot P30677 543
type: UnificationXref
id: P30677
db: uniprot

uniprot O43306 210
type: UnificationXref
id: O43306
db: uniprot

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot P38408 544
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P38409 545
organism: Bos taurus

Adenylate cyclase type 1
type: ProteinReference
xref: PTHR45627:SF12
xref: uniprot Q08828 236
organism: Homo sapiens

uniprot Q9Z1B3 668
type: UnificationXref
id: Q9Z1B3
db: uniprot

PARTICIPANT STOICHIOMETRY re8 679
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(olf) subunit alpha
type: ProteinReference
xref: uniprot P38405 495
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re25 730
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__L_Arg-RIGHT__L_Cit-_NO-_re2
controller: eNOS

uniprot Q02750 367
type: UnificationXref
id: Q02750
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re26
control type: INHIBITION
controller: Ca2+

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 554
evidence: Evidence 556
evidence: Evidence 555
evidence: Evidence 557
xref: PTHR44329:SF22
xref: uniprot A0A2I3THL4 558
organism: Pan troglodytes

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 34

uniprot P20444 142
type: UnificationXref
id: P20444
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot A0A2I3T8F7 635
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1NH21 578
xref: PTHR24356:SF176
organism: Bos taurus

uniprot P31323 311
type: UnificationXref
id: P31323
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot P21708 38
organism: Rattus norvegicus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot Q99JE6 664
organism: Rattus norvegicus

uniprot P24723 145
type: UnificationXref
id: P24723
db: uniprot

uniprot E1BKE7 609
type: UnificationXref
id: E1BKE7
db: uniprot

Inositol 1,4,5-trisphosphate receptor
type: ProteinReference
xref: uniprot P29993 623
xref: PTHR13715:SF87
organism: Drosophila melanogaster

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 229

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P29992 542
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot P29995 625
xref: PTHR13715:SF53
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P29994 624
organism: Rattus norvegicus

uniprot Q9Z329 633
type: UnificationXref
id: Q9Z329
db: uniprot

cGMP-dependent protein kinase 2
type: ProteinReference
xref: uniprot Q13237 93
xref: PTHR24353:SF24
organism: Homo sapiens

eNOS s33 sa29 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

PARTICIPANT STOICHIOMETRY re25 729
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

Danio rerio
type: BioSource
xref: ncbitaxon 7955 63

G protein subunit alpha q
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot K6ZCJ5 538
organism: Pan troglodytes

uniprot P09215 137
type: UnificationXref
id: P09215
db: uniprot

uniprot F6ZCW7 616
type: UnificationXref
id: F6ZCW7
db: uniprot

uniprot Q5A1D3 58
type: UnificationXref
id: Q5A1D3
db: uniprot

cPLA2
type: Protein
entity reference: cPLA2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Nitric oxide synthase, endothelial
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot Q9TUX8 426
organism: Canis lupus familiaris

uniprot A0A2I3T2V8 378
type: UnificationXref
id: A0A2I3T2V8
db: uniprot

uniprot Q9WTR7 394
type: UnificationXref
id: Q9WTR7
db: uniprot

ncbitaxon 214684 328
type: UnificationXref
id: 214684
db: ncbitaxon

uniprot F6RA79 117
type: UnificationXref
id: F6RA79
db: uniprot

Protein kinase C, eye isozyme
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P13677 139
organism: Drosophila melanogaster

Protein kinase C beta type
type: ProteinReference
xref: uniprot Q7SY24 170
xref: PTHR24356:SF158
organism: Danio rerio

Signal peptidase complex catalytic subunit SEC11C
type: ProteinReference
xref: PTHR10806:SF12
xref: uniprot P13679 382
organism: Canis lupus familiaris

uniprot O60266 211
type: UnificationXref
id: O60266
db: uniprot

uniprot P29992 542
type: UnificationXref
id: P29992
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot E1BKE7 609
xref: PTHR13715:SF51
organism: Bos taurus

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 5

cGMP-dependent protein kinase 2
type: ProteinReference
xref: uniprot Q64595 96
xref: PTHR24353:SF24
organism: Rattus norvegicus

uniprot Q9JMI0 524
type: UnificationXref
id: Q9JMI0
db: uniprot

uniprot Q05513 160
type: UnificationXref
id: Q05513
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9VA14 253
organism: Drosophila melanogaster

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0D1C4Y4 4
xref: PTHR24055:SF158
organism: Ustilago maydis

uniprot Q9D8V7 389
type: UnificationXref
id: Q9D8V7
db: uniprot

uniprot P29994 624
type: UnificationXref
id: P29994
db: uniprot

uniprot A0A2I3T9Y4 577
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

PTHR45627:SF11
type: RelationshipXref
id: PTHR45627:SF11
db: PANTHER Family
relationship type: By Homology

PTHR45627:SF10
type: RelationshipXref
id: PTHR45627:SF10
db: PANTHER Family
relationship type: By Homology

uniprot P14138 400
type: UnificationXref
id: P14138
db: uniprot

PTHR45627:SF13
type: RelationshipXref
id: PTHR45627:SF13
db: PANTHER Family
relationship type: By Homology

PTHR45627:SF12
type: RelationshipXref
id: PTHR45627:SF12
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 5
type: ProteinReference
xref: uniprot Q10N20 50
organism: Oryza sativa

uniprot O62698 467
type: UnificationXref
id: O62698
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6XP81 589
organism: Xenopus tropicalis

signal peptidase
type: ProteinReference
xref: P00573
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: signal peptidaseSynonym: Synonym not specifiedAccession: P00573
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.signal_br_peptidase
member entity reference: Signal peptidase complex catalytic subunit SEC11C
member entity reference: Signal peptidase complex catalytic subunit SEC11
member entity reference: Signal peptidase I
member entity reference: Signal peptidase complex catalytic subunit SEC11A
member entity reference: Signal peptidase complex catalytic subunit sec11

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
type: ProteinReference
xref: uniprot Q15147 661
xref: PTHR10336:SF106
organism: Homo sapiens

uniprot Q14573 628
type: UnificationXref
id: Q14573
db: uniprot

uniprot Q27687 321
type: UnificationXref
id: Q27687
db: uniprot

PARTICIPANT STOICHIOMETRY re24 732
type: Stoichiometry
physical entity: NSCC
stoichiometric coefficient: 1.0

PKC
type: Protein
entity reference: PKC
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY re24 731
type: Stoichiometry
physical entity: NSCC
stoichiometric coefficient: 1.0

uniprot P31324 312
type: UnificationXref
id: P31324
db: uniprot

uniprot Q6DNF7 460
type: UnificationXref
id: Q6DNF7
db: uniprot

uniprot Q9Y0A1 632
type: UnificationXref
id: Q9Y0A1
db: uniprot

uniprot P0DPD6 514
type: UnificationXref
id: P0DPD6
db: uniprot

uniprot Q04400 234
type: UnificationXref
id: Q04400
db: uniprot

uniprot F7A767 430
type: UnificationXref
id: F7A767
db: uniprot

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 39

uniprot K6ZCJ5 538
type: UnificationXref
id: K6ZCJ5
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

INHIBITION
type: RelationshipTypeVocabulary

uniprot Q8INF8 244
type: UnificationXref
id: Q8INF8
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot E1BWA3 110
xref: PTHR24356:SF214
organism: Gallus gallus

uniprot Q99JE6 664
type: UnificationXref
id: Q99JE6
db: uniprot

STATE_TRANSITION_LEFT__PLCbeta-RIGHT__PLCbeta-_re21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 737
participant stoichiometry: PARTICIPANT STOICHIOMETRY re21 738
left: PLCbeta
interaction type: STATE_TRANSITION
right: PLCbeta

uniprot F7FHD1 29
type: UnificationXref
id: F7FHD1
db: uniprot

MEK s73 sa48 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3RQJ8 101
xref: PTHR24356:SF214
organism: Pan troglodytes

TRUNCATION
type: InteractionVocabulary

GO GO:0005783 3
type: UnificationXref
id: GO:0005783
db: GO

Receptor-type guanylate cyclase gcy-28
type: ProteinReference
xref: uniprot Q86GV3 461
xref: PTHR11920:SF488
organism: Caenorhabditis elegans

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot G3X7B5 591
xref: PTHR24351:SF200
organism: Bos taurus

uniprot Q01341 230
type: UnificationXref
id: Q01341
db: uniprot

uniprot A0A3Q1M3D6 489
type: UnificationXref
id: A0A3Q1M3D6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_re18
controller: PKC

uniprot P13679 382
type: UnificationXref
id: P13679
db: uniprot

uniprot P47713 484
type: UnificationXref
id: P47713
db: uniprot

eco ECO:0000303 16
type: UnificationXref
id: ECO:0000303
db: eco

uniprot H9FU38 621
type: UnificationXref
id: H9FU38
db: uniprot

eNOS s32 sa30 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

MEK s73 sa48 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Endothelin-1
type: ProteinReference
xref: uniprot P17322 348
organism: Bos taurus

PTHR45627:SF25
type: RelationshipXref
id: PTHR45627:SF25
db: PANTHER Family
relationship type: By Homology

Guanylate cyclase
type: Protein
entity reference: Guanylate cyclase
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot H2QXB9 281
type: UnificationXref
id: H2QXB9
db: uniprot

uniprot P10894 655
type: UnificationXref
id: P10894
db: uniprot

Pre-pro ET1-4
type: Protein
entity reference: Pre-pro ET1-4
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__eNOS-RIGHT__eNOS-_re1
controller: Akt

eNOS
type: Protein
entity reference: eNOS
feature: ACTIVE 76
feature: eNOS s33 sa29 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

AA
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot P34099 313
organism: Dictyostelium discoideum

Akt
type: ProteinReference
xref: P00589
standard name: protein kinase B
comment: ENTITY_REFERENCE_NOTES=Long Name: Thymoma viral proto-oncogeneSynonym: PKB,RAC protein kinase,protein kinase BAccession: P00589
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Akt
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: RAC serine/threonine-protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-2
member entity reference: Serine/threonine-protein kinase akt-1
member entity reference: V-akt murine thymoma viral oncogene homolog 2,-like

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 2

uniprot P05130 135
type: UnificationXref
id: P05130
db: uniprot

cAMP-dependent protein kinase catalytic subunit 3
type: ProteinReference
xref: uniprot P16912 302
xref: PTHR24353:SF37
organism: Drosophila melanogaster

NO
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF10
xref: uniprot E2RT75 639
organism: Canis lupus familiaris

EDN1 isoform 1
type: ProteinReference
xref: uniprot H2QSB1 345
xref: PTHR13874:SF10
organism: Pan troglodytes

uniprot P63318 152
type: UnificationXref
id: P63318
db: uniprot

cAMP-dependent protein kinase type I regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P16905 301
organism: Drosophila melanogaster

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: uniprot Q3ZB92 324
xref: PTHR24353:SF116
organism: Danio rerio

uniprot P31749 593
type: UnificationXref
id: P31749
db: uniprot

ncbitaxon 367110 75
type: UnificationXref
id: 367110
db: ncbitaxon

uniprot A0A2R8QJ48 103
type: UnificationXref
id: A0A2R8QJ48
db: uniprot

Protein kinase A catalytic subunit isoform 1
type: ProteinReference
xref: PTHR24353:SF67
xref: uniprot Q9GNR4 340
organism: Leishmania major

uniprot O59922 286
type: UnificationXref
id: O59922
db: uniprot

uniprot Q9W5Y0 527
type: UnificationXref
id: Q9W5Y0
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q63932 373
xref: PTHR48013:SF8
organism: Mus musculus

GUCY1A3 isoform 1
type: ProteinReference
xref: uniprot A0A2J8MUU7 447
organism: Pan troglodytes

uniprot P10644 294
type: UnificationXref
id: P10644
db: uniprot

uniprot P51830 225
type: UnificationXref
id: P51830
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot A0A1D5Q874 175
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6RCU6 588
organism: Macaca mulatta

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6TQN3 644
xref: PTHR10336:SF106
organism: Monodelphis domestica

uniprot F1PNQ0 192
type: UnificationXref
id: F1PNQ0
db: uniprot

uniprot A0A3Q2UD13 608
type: UnificationXref
id: A0A3Q2UD13
db: uniprot

Pro ET1-4
type: ProteinReference
xref: P00571
standard name: Pro endothelin 1, 2, 3, and 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Pro endothelin 1, 2, 3, and 4Synonym: Synonym not specifiedAccession: P00571
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Pro_br_ET1_minus_4
member entity reference: Endothelin-2
member entity reference: Endothelin-1
member entity reference: EDN1 isoform 1
member entity reference: Uncharacterized protein

LPL
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

uniprot P24530 435
type: UnificationXref
id: P24530
db: uniprot

ERK s29 sa59 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot P42891 516
type: UnificationXref
id: P42891
db: uniprot

Signal peptidase complex catalytic subunit SEC11C
type: ProteinReference
xref: uniprot Q9D8V7 389
xref: PTHR10806:SF12
organism: Mus musculus

uniprot F7H3B3 125
type: UnificationXref
id: F7H3B3
db: uniprot

uniprot O95837 539
type: UnificationXref
id: O95837
db: uniprot

Protein CBR-MEK-2
type: ProteinReference
xref: PTHR48013:SF19
xref: uniprot A8WWD7 357
organism: Caenorhabditis briggsae

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q02956 158
organism: Mus musculus

ERK s29 sa59 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.17
comment: MODIFICATION_RESIDUE_NAME=

uniprot P28840 414
type: UnificationXref
id: P28840
db: uniprot

uniprot F6V001 193
type: UnificationXref
id: F6V001
db: uniprot

PTHR10218:SF212
type: RelationshipXref
id: PTHR10218:SF212
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot H9ZA60 650
xref: PTHR10336:SF10
organism: Macaca mulatta

PTHR10218:SF213
type: RelationshipXref
id: PTHR10218:SF213
db: PANTHER Family
relationship type: By Homology

Protein kinase C eta type
type: ProteinReference
xref: uniprot Q64617 167
xref: PTHR24356:SF192
organism: Rattus norvegicus

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q9Z329 633
xref: PTHR13715:SF53
organism: Mus musculus

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: PTHR10806:SF6
xref: uniprot A8WWE1 379
organism: Caenorhabditis briggsae

Protein kinase C gamma type
type: ProteinReference
xref: uniprot P63318 152
xref: PTHR24356:SF162
organism: Mus musculus

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63319 153
organism: Rattus norvegicus

Endothelin receptor type A
type: ProteinReference
xref: PTHR46099:SF2
xref: uniprot Q0VA29 440
organism: Xenopus tropicalis

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot F6VHF7 614
xref: PTHR13715:SF52
organism: Xenopus tropicalis

uniprot H9FVW1 649
type: UnificationXref
id: H9FVW1
db: uniprot

uniprot Q91UZ1 663
type: UnificationXref
id: Q91UZ1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9VAY0 525
organism: Drosophila melanogaster

uniprot P27607 468
type: UnificationXref
id: P27607
db: uniprot

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot Q5KNS1 327
organism: Cryptococcus neoformans

uniprot C8V7D1 14
type: UnificationXref
id: C8V7D1
db: uniprot

uniprot E1BS74 490
type: UnificationXref
id: E1BS74
db: uniprot

uniprot Q7PPI8 333
type: UnificationXref
id: Q7PPI8
db: uniprot

uniprot P68182 317
type: UnificationXref
id: P68182
db: uniprot

uniprot P48299 401
type: UnificationXref
id: P48299
db: uniprot

uniprot F6QP11 586
type: UnificationXref
id: F6QP11
db: uniprot

Adenylate cyclase type 6
type: ProteinReference
xref: uniprot P30804 219
xref: PTHR45627:SF11
organism: Canis lupus familiaris

uniprot Q6R0H7 498
type: UnificationXref
id: Q6R0H7
db: uniprot

Endothelin converting enzyme like 1
type: ProteinReference
xref: uniprot A0A3Q1MZN0 504
xref: PTHR11733:SF195
organism: Bos taurus

uniprot Q7PXF7 334
type: UnificationXref
id: Q7PXF7
db: uniprot

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot P10644 294
xref: PTHR11635:SF129
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q9XT09 375
organism: Pan troglodytes

uniprot P42667 384
type: UnificationXref
id: P42667
db: uniprot

Endothelin receptor type B
type: ProteinReference
xref: PTHR46099:SF3
xref: uniprot P24530 435
organism: Homo sapiens

Endothelin receptor type A
type: ProteinReference
xref: PTHR46099:SF2
xref: uniprot O73739 433
organism: Gallus gallus

uniprot Q39023 54
type: UnificationXref
id: Q39023
db: uniprot

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: PTHR10806:SF6
xref: uniprot Q9N3D0 391
organism: Caenorhabditis elegans

uniprot F7H582 200
type: UnificationXref
id: F7H582
db: uniprot

uniprot Q0VA29 440
type: UnificationXref
id: Q0VA29
db: uniprot

ncbitaxon 284812 43
type: UnificationXref
id: 284812
db: ncbitaxon

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q9FXT7 69
organism: Chlamydomonas reinhardtii

uniprot Q39027 57
type: UnificationXref
id: Q39027
db: uniprot

uniprot Q7SY24 170
type: UnificationXref
id: Q7SY24
db: uniprot

MEK
type: Protein
entity reference: MEK
feature: MEK s70 sa49 rs1
feature: MEK s70 sa49 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Adenylate cyclase
type: ProteinReference
xref: uniprot F1MPC9 191
xref: PTHR45627:SF13
organism: Bos taurus

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot J9P5W6 361
organism: Canis lupus familiaris

MAP2K1 protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q0VD16 368
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CB49 492
organism: Monodelphis domestica

MEK
type: ProteinReference
xref: P00572
standard name: Mitogen-activated protein kinase kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: MAP/ERK kinaseSynonym: Dual specificity mitogen-activated protein kinase kinase,ERK activator kinase,MAP kinase kinaseAccession: P00572
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.MEK
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Dual specificity mitogen-activated protein kinase kinase mek-2
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: Uncharacterized protein
member entity reference: MAP2K2 isoform 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase dSOR1
member entity reference: Protein CBR-MEK-2
member entity reference: MAP2K1 protein
member entity reference: Mitogen-activated protein kinase kinase 2

uniprot F7FQJ7 397
type: UnificationXref
id: F7FQJ7
db: uniprot

uniprot Q61614 442
type: UnificationXref
id: Q61614
db: uniprot

uniprot F6Q503 271
type: UnificationXref
id: F6Q503
db: uniprot

Endothelin receptor type B
type: ProteinReference
xref: PTHR46099:SF3
xref: uniprot P28088 438
organism: Bos taurus

endoplasmic reticulum
type: CellularLocationVocabulary
xref: GO GO:0005783 3

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
type: ProteinReference
xref: uniprot Q6R0H7 498
organism: Mus musculus

TRUNCATION
type: RelationshipTypeVocabulary

Phospholipase A2
type: ProteinReference
evidence: Evidence 477
xref: uniprot F6UQ33 479
xref: PTHR10728:SF13
organism: Canis lupus familiaris

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9Y243 605
xref: PTHR24356:SF190
organism: Homo sapiens

uniprot Q5KNS1 327
type: UnificationXref
id: Q5KNS1
db: uniprot

uniprot P22717 455
type: UnificationXref
id: P22717
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot Q9V9R3 252
xref: PTHR45627:SF13
organism: Drosophila melanogaster

MAP2K2 isoform 1
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot K7BYT0 362
organism: Pan troglodytes

uniprot Q17941 598
type: UnificationXref
id: Q17941
db: uniprot

mitogenesis
type: Pathway

Endothelin-converting enzyme 2
type: ProteinReference
xref: uniprot P0DPD6 514
organism: Homo sapiens

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q02156 157
organism: Homo sapiens

EEF1AKMT4-ECE2 readthrough transcript protein
type: ProteinReference
xref: uniprot P0DPD9 515
organism: Mus musculus

Guanylate cyclase soluble subunit beta-1
type: ProteinReference
xref: uniprot Q02153 458
organism: Homo sapiens

Protein kinase, cAMP-dependent, regulatory, type I, beta
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot Q08C49 320
organism: Danio rerio

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot P31938 363
organism: Mus musculus

uniprot P25455 657
type: UnificationXref
id: P25455
db: uniprot

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

PTHR46099:SF2
type: RelationshipXref
id: PTHR46099:SF2
db: PANTHER Family
relationship type: By Homology

PTHR46099:SF4
type: RelationshipXref
id: PTHR46099:SF4
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6VQP7 615
xref: PTHR13715:SF52
organism: Monodelphis domestica

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot P70227 626
xref: PTHR13715:SF51
organism: Mus musculus

uniprot F6STK5 428
type: UnificationXref
id: F6STK5
db: uniprot

PTHR46099:SF3
type: RelationshipXref
id: PTHR46099:SF3
db: PANTHER Family
relationship type: By Homology

Protein kinase C-like 1
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P24583 144
organism: Saccharomyces cerevisiae

Adenylate cyclase type 4
type: ProteinReference
xref: PTHR45627:SF10
xref: uniprot Q8NFM4 246
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot E1B8P9 17
organism: Bos taurus

EDN2 isoform 1
type: ProteinReference
xref: uniprot H2PYT1 398
organism: Pan troglodytes

uniprot P10398 568
type: UnificationXref
id: P10398
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 195

cGMP-dependent protein kinase
type: ProteinReference
xref: PTHR24353:SF24
xref: uniprot F6Y448 80
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Adenylate_cyclase-RIGHT__Adenylate_cyclase-_re4
controller: Gs

Endothelin-3
type: ProteinReference
xref: uniprot P48299 401
xref: PTHR13874:SF11
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot O89040 653
xref: PTHR10336:SF10
organism: Rattus norvegicus

ncbitaxon 9031 78
type: UnificationXref
id: 9031
db: ncbitaxon

PKA
type: ProteinReference
xref: P00570
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Cytosolic phospholipase A2Synonym: Lysophospholipase,Phosphatidylcholine 2-acylhydrolaseAccession: P00583
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PKA
member entity reference: cAMP-dependent protein kinase type I-alpha regulatory subunit
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: cAMP-dependent protein kinase regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: cAMP-dependent protein kinase catalytic subunit 3
member entity reference: AGAP004940-PA
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue-specific extinguisher 1) b
member entity reference: Uncharacterized protein
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: Protein kinase cAMP-dependent type I regulatory subunit alpha
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: PRKACB isoform 3
member entity reference: PRKACG isoform 1
member entity reference: AGAP001384-PA
member entity reference: Protein kinase, cAMP-dependent, regulatory, type I, beta
member entity reference: PRKAR1A isoform 12
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: CAP family transcription factor
member entity reference: Protein kinase A catalytic subunit
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta a
member entity reference: Protein kinase A regulatory subunit
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: cAMP-dependent protein kinase type I-beta regulatory subunit
member entity reference: Protein kinase A catalytic subunit isoform 2
member entity reference: Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
member entity reference: PRKAR2A isoform 1
member entity reference: cAMP-dependent protein kinase type I regulatory subunit
member entity reference: Prkar1a protein
member entity reference: Protein kinase A catalytic subunit isoform 1

uniprot F7EH19 26
type: UnificationXref
id: F7EH19
db: uniprot

IP3 R
type: Protein
entity reference: IP3 R
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9615 20
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot O60503 212
type: UnificationXref
id: O60503
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E823 24
xref: PTHR24055:SF203
organism: Monodelphis domestica

uniprot E2RT75 639
type: UnificationXref
id: E2RT75
db: uniprot

uniprot P28867 146
type: UnificationXref
id: P28867
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A818 617
xref: PTHR13715:SF53
organism: Macaca mulatta

uniprot A0A452DI16 559
type: UnificationXref
id: A0A452DI16
db: uniprot

uniprot P24583 144
type: UnificationXref
id: P24583
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GTP-RIGHT__cGMP-_re8
controller: Guanylate cyclase

STATE_TRANSITION_LEFT__IP3_R-RIGHT__IP3_R-_re15
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 706
participant stoichiometry: PARTICIPANT STOICHIOMETRY re15 705
left: IP3 R
interaction type: STATE_TRANSITION
right: IP3 R

IP3 R
type: Protein
entity reference: IP3 R
feature: ACTIVE 76
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=PROTEIN

Nitric oxide synthase
type: ProteinReference
xref: uniprot A0A3Q1LSD1 420
xref: PTHR19384:SF66
organism: Bos taurus

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 20

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q08BT6 162
organism: Xenopus tropicalis

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q80TL1 242
xref: PTHR45627:SF6
organism: Mus musculus

Adenylate cyclase type 9
type: ProteinReference
xref: uniprot P51830 225
xref: PTHR45627:SF8
organism: Mus musculus

uniprot P07278 293
type: UnificationXref
id: P07278
db: uniprot

STATE_TRANSITION_LEFT__NSCC-RIGHT__NSCC-_re24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 732
participant stoichiometry: PARTICIPANT STOICHIOMETRY re24 731
left: NSCC
interaction type: STATE_TRANSITION
right: NSCC

uniprot Q61410 95
type: UnificationXref
id: Q61410
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_re22
controller: PI3 K

Uncharacterized protein
type: ProteinReference
xref: PTHR46099:SF2
xref: uniprot F6STK5 428
organism: Monodelphis domestica

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q02111 156
xref: PTHR24356:SF181
organism: Mus musculus

uniprot Q3ZB92 324
type: UnificationXref
id: Q3ZB92
db: uniprot

ncbitaxon 9913 18
type: UnificationXref
id: 9913
db: ncbitaxon

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot P51828 223
organism: Homo sapiens

uniprot A7F3M0 12
type: UnificationXref
id: A7F3M0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot F7ECA6 534
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot P21278 540
organism: Mus musculus

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot P51829 224
xref: PTHR45627:SF9
organism: Mus musculus

Guanine nucleotide-binding protein G(q) subunit alpha
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot P21279 541
organism: Mus musculus

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_re13
controller: PLCbeta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 26
organism: Xenopus tropicalis

Signal peptidase complex catalytic subunit sec11
type: ProteinReference
xref: uniprot O74323 380
xref: PTHR10806:SF6
organism: Schizosaccharomyces pombe

Protein kinase C beta type
type: ProteinReference
xref: uniprot P68404 154
xref: PTHR24356:SF158
organism: Mus musculus

Adenylate cyclase
type: ProteinReference
xref: uniprot F1PNQ0 192
xref: PTHR45627:SF13
organism: Canis lupus familiaris

uniprot F1MDC9 114
type: UnificationXref
id: F1MDC9
db: uniprot

Guanylate cyclase soluble subunit alpha-1
type: ProteinReference
xref: uniprot Q02108 457
organism: Homo sapiens

uniprot Q9VY22 260
type: UnificationXref
id: Q9VY22
db: uniprot

uniprot K7AEL3 285
type: UnificationXref
id: K7AEL3
db: uniprot

uniprot F7EI48 28
type: UnificationXref
id: F7EI48
db: uniprot

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot Q28FH0 547
organism: Xenopus tropicalis

G protein, Subunit Alpha
type: ProteinReference
xref: uniprot Q7KPV0 499
xref: PTHR10218:SF212
organism: Caenorhabditis elegans

uniprot Q15147 661
type: UnificationXref
id: Q15147
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F6VVA6 645
xref: PTHR10336:SF12
organism: Ornithorhynchus anatinus

uniprot O97066 381
type: UnificationXref
id: O97066
db: uniprot

Protein CBR-ACY-1
type: ProteinReference
xref: uniprot A8XSS7 181
xref: PTHR45627:SF8
organism: Caenorhabditis briggsae

uniprot H2RA86 32
type: UnificationXref
id: H2RA86
db: uniprot

Guanylate cyclase 1 soluble subunit beta 1
type: ProteinReference
xref: uniprot A0A2I3RI58 445
organism: Pan troglodytes

Adenylate cyclase type 7
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot Q29450 239
organism: Bos taurus

Raf-1
type: Protein
entity reference: Raf-1
feature: ACTIVE 76
feature: Raf 1 s72 sa34 rs2
feature: Raf 1 s72 sa34 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F7DVL1 123
organism: Xenopus tropicalis

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot H2QAS6 128
organism: Pan troglodytes

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re25
control type: ACTIVATION
controller: IP3 R

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Big_ET1_4-RIGHT__ET1_4-_?-_re29
controller: ECE1-3

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot Q5ANK2 164
organism: Candida albicans

uniprot E2REI6 560
type: UnificationXref
id: E2REI6
db: uniprot

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot P81900 318
organism: Drosophila melanogaster

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot P22612 305
organism: Homo sapiens

Furin-like protease 2
type: ProteinReference
xref: uniprot P30432 416
xref: PTHR42884:SF23
organism: Drosophila melanogaster

DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_re13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 712
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 711
participant stoichiometry: PARTICIPANT STOICHIOMETRY re13 713
left: PIP2
interaction type: DISSOCIATION
right: IP3
right: DAG

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot P29120 415
organism: Homo sapiens

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P47196 596
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot O95837 539
organism: Homo sapiens

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47197 597
xref: PTHR24356:SF176
organism: Rattus norvegicus

uniprot P23943 353
type: UnificationXref
id: P23943
db: uniprot

ECE1-3
type: ProteinReference
xref: P00585
standard name: Endothelin-coverting enzyme 1, 2, and 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.ECE1_minus_3
comment: ENTITY_REFERENCE_NOTES=Long Name: Endothelin-coverting enzyme 1, 2, and 3Synonym: Synonym not specifiedAccession: P00585
member entity reference: Neprilysin-21
member entity reference: ECE1 isoform 4
member entity reference: Endothelin-converting enzyme 1
member entity reference: EEF1AKMT4-ECE2 readthrough transcript protein
member entity reference: Neprilysin-3
member entity reference: Uncharacterized protein
member entity reference: Endothelin converting enzyme 1
member entity reference: ECEL1 isoform 1
member entity reference: Endothelin converting enzyme like 1
member entity reference: NEPrilysin metallopeptidase family
member entity reference: GH26575p
member entity reference: Endothelin-converting enzyme-like 1
member entity reference: AGAP007796-PA
member entity reference: Endothelin-converting enzyme 2
member entity reference: AGAP002441-PA
member entity reference: Protein CBG04739

uniprot H2QUJ4 205
type: UnificationXref
id: H2QUJ4
db: uniprot

Guanylate cyclase soluble subunit alpha-1
type: ProteinReference
xref: uniprot P19686 453
organism: Rattus norvegicus

Protein kinase C beta type
type: ProteinReference
xref: uniprot P05771 136
xref: PTHR24356:SF158
organism: Homo sapiens

uniprot Q9W038 262
type: UnificationXref
id: Q9W038
db: uniprot

uniprot P34722 147
type: UnificationXref
id: P34722
db: uniprot

Nitric oxide synthase
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot A0A1D5QGM1 419
organism: Macaca mulatta

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q9S4 272
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: uniprot A0A1D5R985 100
xref: PTHR24356:SF193
organism: Macaca mulatta

cGMP-dependent protein kinase
type: ProteinReference
xref: uniprot H2Q1X0 85
xref: PTHR24353:SF68
organism: Pan troglodytes

uniprot A0A2I3TMR3 503
type: UnificationXref
id: A0A2I3TMR3
db: uniprot

uniprot P26770 218
type: UnificationXref
id: P26770
db: uniprot

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H2QFK0 280
organism: Pan troglodytes

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E2RNP2 112
organism: Canis lupus familiaris

uniprot A0A2J8KMQ0 395
type: UnificationXref
id: A0A2J8KMQ0
db: uniprot

uniprot A0A1D5RIY6 377
type: UnificationXref
id: A0A1D5RIY6
db: uniprot

uniprot E1BQ12 186
type: UnificationXref
id: E1BQ12
db: uniprot

uniprot P48302 439
type: UnificationXref
id: P48302
db: uniprot

Proprotein convertase subtilisin/kexin type 1
type: ProteinReference
xref: uniprot E2QX69 403
organism: Canis lupus familiaris

uniprot P28482 44
type: UnificationXref
id: P28482
db: uniprot

Endothelin-converting enzyme 2
type: ProteinReference
xref: uniprot D4A4U1 506
organism: Rattus norvegicus

uniprot F7D9M6 198
type: UnificationXref
id: F7D9M6
db: uniprot

uniprot Q5ANK2 164
type: UnificationXref
id: Q5ANK2
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 66

uniprot A0A1D5R670 376
type: UnificationXref
id: A0A1D5R670
db: uniprot

STATE_TRANSITION_LEFT__GTP-RIGHT__cGMP-_re8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 679
participant stoichiometry: PARTICIPANT STOICHIOMETRY re8 680
left: GTP
interaction type: STATE_TRANSITION
right: cGMP

uniprot H2QJY5 648
type: UnificationXref
id: H2QJY5
db: uniprot

uniprot Q1HG70 370
type: UnificationXref
id: Q1HG70
db: uniprot

uniprot P40145 221
type: UnificationXref
id: P40145
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot P26769 217
xref: PTHR45627:SF6
organism: Rattus norvegicus

uniprot A0A2I3SR38 102
type: UnificationXref
id: A0A2I3SR38
db: uniprot

ncbitaxon 83332 229
type: UnificationXref
id: 83332
db: ncbitaxon

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot A0A1D5QKD3 355
xref: PTHR48013:SF5
organism: Macaca mulatta

furin
type: Protein
entity reference: furin
comment: SPECIES_TYPE=PROTEIN

uniprot Q961H2 249
type: UnificationXref
id: Q961H2
db: uniprot

STATE_TRANSITION_LEFT__cPLA2-RIGHT__cPLA2-_re16
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 701
participant stoichiometry: PARTICIPANT STOICHIOMETRY re16 700
left: cPLA2
interaction type: STATE_TRANSITION
right: cPLA2

ncbitaxon 39947 51
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot E2RL20 561
type: UnificationXref
id: E2RL20
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot E1B9K3 183
organism: Bos taurus

uniprot E2RCX6 188
type: UnificationXref
id: E2RCX6
db: uniprot

uniprot Q9VH96 526
type: UnificationXref
id: Q9VH96
db: uniprot

Nitric oxide synthase
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot H2QVM2 422
organism: Pan troglodytes

uniprot Q07292 573
type: UnificationXref
id: Q07292
db: uniprot

ncbitaxon 559292 36
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot P20354 494
type: UnificationXref
id: P20354
db: uniprot

Furin, paired basic amino acid cleaving enzyme
type: ProteinReference
xref: uniprot E2RSE6 404
xref: PTHR42884:SF1
organism: Canis lupus familiaris

PKG
type: Protein
entity reference: PKG
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6PV18 491
type: UnificationXref
id: F6PV18
db: uniprot

uniprot F6S9S9 359
type: UnificationXref
id: F6S9S9
db: uniprot

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 273

uniprot P28088 438
type: UnificationXref
id: P28088
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P16054 140
organism: Mus musculus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot F7EG64 124
organism: Xenopus tropicalis

uniprot F5HEA9 22
type: UnificationXref
id: F5HEA9
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot F1P3G1 116
organism: Gallus gallus

uniprot F1Q4F8 584
type: UnificationXref
id: F1Q4F8
db: uniprot

Adenylate cyclase type 3
type: ProteinReference
xref: PTHR45627:SF13
xref: uniprot O60266 211
organism: Homo sapiens

PTHR19384:SF66
type: RelationshipXref
id: PTHR19384:SF66
db: PANTHER Family
relationship type: By Homology

uniprot Q7QK56 600
type: UnificationXref
id: Q7QK56
db: uniprot

uniprot D4A3N4 182
type: UnificationXref
id: D4A3N4
db: uniprot

PKG
type: Protein
entity reference: PKG
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

uniprot A4IFJ5 476
type: UnificationXref
id: A4IFJ5
db: uniprot

Adenylate cyclase 9
type: ProteinReference
xref: uniprot E2R4W4 187
xref: PTHR45627:SF8
organism: Canis lupus familiaris

ERK
type: ProteinReference
xref: P00566
standard name: extracellular signal-regulated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.ERK
comment: ENTITY_REFERENCE_NOTES=Long Name: extracellular signal-regulated kinaseSynonym: MAPK,Mitogen-activated protein kinase,mitogen-activated protein kinase,p42/44,pp42/44Accession: P00566
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Uncharacterized protein
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 7
member entity reference: Mitogen-activated protein kinase 2
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase mpk-1
member entity reference: Mitogen-activated protein kinase spk1
member entity reference: Mitogen-activated protein kinase FUS3
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase KSS1
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Mitogen-activated protein kinase 4
member entity reference: Mitogen-activated protein kinase 5
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase (Fragment)

uniprot Q4QF64 325
type: UnificationXref
id: Q4QF64
db: uniprot

IDA
type: EvidenceCodeVocabulary

ncbitaxon 36329 99
type: UnificationXref
id: 36329
db: ncbitaxon

PARTICIPANT STOICHIOMETRY re22 735
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re22 736
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

uniprot J9P5W6 361
type: UnificationXref
id: J9P5W6
db: uniprot

uniprot F1PLB3 641
type: UnificationXref
id: F1PLB3
db: uniprot

uniprot A0NC47 179
type: UnificationXref
id: A0NC47
db: uniprot

uniprot Q96PN6 250
type: UnificationXref
id: Q96PN6
db: uniprot

uniprot P26684 437
type: UnificationXref
id: P26684
db: uniprot

uniprot P31938 363
type: UnificationXref
id: P31938
db: uniprot

uniprot F6T0T9 275
type: UnificationXref
id: F6T0T9
db: uniprot

PARTICIPANT STOICHIOMETRY re27 725
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

Guanylate cyclase 1, soluble, alpha 2
type: ProteinReference
xref: uniprot F8VQK3 451
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re27 726
type: Stoichiometry
physical entity: Pro ET1-4
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7FHD1 29
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re27 724
type: Stoichiometry
physical entity: Pre-pro ET1-4
stoichiometric coefficient: 1.0

Endothelin-converting enzyme-like 1
type: ProteinReference
xref: PTHR11733:SF195
xref: uniprot Q9JHL3 523
organism: Rattus norvegicus

PTHR11733:SF130
type: RelationshipXref
id: PTHR11733:SF130
db: PANTHER Family
relationship type: By Homology

uniprot P63086 49
type: UnificationXref
id: P63086
db: uniprot

PCSK1 isoform 2
type: ProteinReference
xref: uniprot H2QR92 409
organism: Pan troglodytes

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

uniprot E2R4W4 187
type: UnificationXref
id: E2R4W4
db: uniprot

uniprot Q66JE6 374
type: UnificationXref
id: Q66JE6
db: uniprot

uniprot Q9LMM5 71
type: UnificationXref
id: Q9LMM5
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F5HEA9 22
xref: PTHR24055:SF158
organism: Phaeosphaeria nodorum

PTHR10806:SF12
type: RelationshipXref
id: PTHR10806:SF12
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot F7D9M6 198
organism: Macaca mulatta

Endothelin receptor type B
type: ProteinReference
xref: PTHR46099:SF3
xref: uniprot P48302 439
organism: Mus musculus

uniprot O16652 511
type: UnificationXref
id: O16652
db: uniprot

uniprot P05625 567
type: UnificationXref
id: P05625
db: uniprot

uniprot P36582 149
type: UnificationXref
id: P36582
db: uniprot

uniprot H2QQ94 432
type: UnificationXref
id: H2QQ94
db: uniprot

uniprot F5HMB9 642
type: UnificationXref
id: F5HMB9
db: uniprot

PKC
type: ProteinReference
xref: P00568
standard name: protein kinase c
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: inositol 1,4,5-triphosphate receptorSynonym: Synonym not specifiedAccession: P00590
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.PKC
member entity reference: Protein kinase C
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C iota type
member entity reference: Protein kinase C-like
member entity reference: Protein kinase C-like 3
member entity reference: Protein kinase C alpha type
member entity reference: Protein kinase C eta type
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C, brain isozyme
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C theta type
member entity reference: Protein kinase C-like 1
member entity reference: Protein kinase C zeta type
member entity reference: Protein kinase C, eye isozyme
member entity reference: Protein kinase C-like 2
member entity reference: Protein kinase C-like 1B
member entity reference: Protein kinase C gamma type (Fragment)
member entity reference: AGAP012252-PA (Fragment)

Guanylate cyclase soluble subunit beta-1
type: ProteinReference
xref: uniprot P20595 454
organism: Rattus norvegicus

uniprot F7CB49 492
type: UnificationXref
id: F7CB49
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 575
xref: uniprot Q99N57 574
xref: PTHR44329:SF22
organism: Mus musculus

uniprot F7A818 617
type: UnificationXref
id: F7A818
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 41

PTHR11733:SF127
type: RelationshipXref
id: PTHR11733:SF127
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF157
type: RelationshipXref
id: PTHR11635:SF157
db: PANTHER Family
relationship type: By Homology

Adenylate cyclase type 4
type: ProteinReference
xref: PTHR45627:SF10
xref: uniprot P26770 218
organism: Rattus norvegicus

PTHR42884:SF3
type: RelationshipXref
id: PTHR42884:SF3
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

PTHR42884:SF1
type: RelationshipXref
id: PTHR42884:SF1
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF152
type: RelationshipXref
id: PTHR11635:SF152
db: PANTHER Family
relationship type: By Homology

PTHR10806:SF28
type: RelationshipXref
id: PTHR10806:SF28
db: PANTHER Family
relationship type: By Homology

uniprot P49147 485
type: UnificationXref
id: P49147
db: uniprot

PTHR10806:SF27
type: RelationshipXref
id: PTHR10806:SF27
db: PANTHER Family
relationship type: By Homology

uniprot Q10664 369
type: UnificationXref
id: Q10664
db: uniprot

uniprot Q9FXT7 69
type: UnificationXref
id: Q9FXT7
db: uniprot

ET1-4
type: ProteinReference
xref: P00588
standard name: Endothelin 1, 2, 3, and 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Endothelin 1, 2, 3, and 4Synonym: EDN1,EDN2,EDN3,EDN4,VIC,Vasoactive instestinal contractor peptideAccession: P00588
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.ET1_minus_4
member entity reference: Endothelin-2
member entity reference: Endothelin-3
member entity reference: Endothelin-1
member entity reference: Endothelin 1
member entity reference: Uncharacterized protein
member entity reference: EDN1 isoform 1
member entity reference: EDN3 isoform 1

uniprot F6VHF7 614
type: UnificationXref
id: F6VHF7
db: uniprot

uniprot E9AFM1 268
type: UnificationXref
id: E9AFM1
db: uniprot

uniprot F6R8N3 587
type: UnificationXref
id: F6R8N3
db: uniprot

uniprot F6QE96 585
type: UnificationXref
id: F6QE96
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P22694 306
organism: Homo sapiens

uniprot O54865 452
type: UnificationXref
id: O54865
db: uniprot

uniprot A0A1D5Q874 175
type: UnificationXref
id: A0A1D5Q874
db: uniprot

uniprot P20595 454
type: UnificationXref
id: P20595
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q1HG70 370
organism: Canis lupus familiaris

uniprot Q01386 319
type: UnificationXref
id: Q01386
db: uniprot

PRKAR2A isoform 1
type: ProteinReference
xref: uniprot K7AEL3 285
xref: PTHR11635:SF153
organism: Pan troglodytes

uniprot P29995 625
type: UnificationXref
id: P29995
db: uniprot

uniprot H2Q0T0 482
type: UnificationXref
id: H2Q0T0
db: uniprot

Guanine nucleotide-binding protein (G protein), q polypeptide
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot B8JLJ7 530
organism: Danio rerio

ncbitaxon 13616 25
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot A0A1D5RKF6 444
type: UnificationXref
id: A0A1D5RKF6
db: uniprot

uniprot Q7PW25 662
type: UnificationXref
id: Q7PW25
db: uniprot

ACXA, isoform A
type: ProteinReference
xref: uniprot Q9VK51 255
organism: Drosophila melanogaster

ACXB
type: ProteinReference
xref: uniprot Q9VK52 256
organism: Drosophila melanogaster

Adenylyl cyclase X E
type: ProteinReference
xref: uniprot Q9VK50 254
organism: Drosophila melanogaster

uniprot Q62600 425
type: UnificationXref
id: Q62600
db: uniprot

PARTICIPANT STOICHIOMETRY re4 693
type: Stoichiometry
physical entity: Adenylate cyclase
stoichiometric coefficient: 1.0

uniprot P05126 132
type: UnificationXref
id: P05126
db: uniprot

uniprot P05305 346
type: UnificationXref
id: P05305
db: uniprot

PARTICIPANT STOICHIOMETRY re4 694
type: Stoichiometry
physical entity: Adenylate cyclase
stoichiometric coefficient: 1.0

ACXC, isoform A
type: ProteinReference
xref: uniprot Q9VK53 257
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__Gq-RIGHT__Gq-_re23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 733
participant stoichiometry: PARTICIPANT STOICHIOMETRY re23 734
left: Gq
interaction type: STATE_TRANSITION
right: Gq

ncbitaxon 7165 66
type: UnificationXref
id: 7165
db: ncbitaxon

IP3 R
type: ProteinReference
xref: P00590
standard name: inositol 1,4,5-triphosphate receptor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=ION_CHANNEL
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.ION_CHANNEL.IP_sub_3_endsub__br_R
comment: ENTITY_REFERENCE_NOTES=Long Name: inositol 1,4,5-triphosphate receptorSynonym: Synonym not specifiedAccession: P00590
member entity reference: Inositol 1,4,5-trisphosphate receptor type 3
member entity reference: AGAP006475-PA
member entity reference: Uncharacterized protein
member entity reference: Inositol 1,4,5-trisphosphate receptor type 2
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1
member entity reference: Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
member entity reference: Inositol 1,4,5-trisphosphate receptor itr-1
member entity reference: Protein CBR-ITR-1, isoform a
member entity reference: Inositol 1,4,5-trisphosphate receptor

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot A0A2J8QDF6 636
xref: PTHR10336:SF10
organism: Pan troglodytes

Raf-1
type: Protein
entity reference: Raf-1
feature: Raf 1 s71 sa35 rs1
feature: Raf 1 s71 sa35 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

PTHR11635:SF129
type: RelationshipXref
id: PTHR11635:SF129
db: PANTHER Family
relationship type: By Homology

PTHR11635:SF126
type: RelationshipXref
id: PTHR11635:SF126
db: PANTHER Family
relationship type: By Homology

uniprot F1MJV4 190
type: UnificationXref
id: F1MJV4
db: uniprot

Prostaglandin G/H synthase 2
type: ProteinReference
xref: PTHR11903:SF8
xref: uniprot P35355 470
organism: Rattus norvegicus

Prostaglandin G/H synthase 2
type: ProteinReference
xref: PTHR11903:SF8
xref: uniprot P35354 469
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re1 707
type: Stoichiometry
physical entity: eNOS
stoichiometric coefficient: 1.0

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 16

PARTICIPANT STOICHIOMETRY re1 708
type: Stoichiometry
physical entity: eNOS
stoichiometric coefficient: 1.0

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 462

uniprot F6XMN6 119
type: UnificationXref
id: F6XMN6
db: uniprot

uniprot Q9VK53 257
type: UnificationXref
id: Q9VK53
db: uniprot

Cyclooxygenase 2
type: ProteinReference
xref: uniprot Q8SPQ9 475
xref: PTHR11903:SF8
organism: Canis lupus familiaris

uniprot H8WGV2 620
type: UnificationXref
id: H8WGV2
db: uniprot

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot A0A3S5ZPX3 356
xref: PTHR48013:SF8
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot J9JHK9 651
organism: Canis lupus familiaris

uniprot A0A3Q1MSP9 104
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot P09217 138
organism: Rattus norvegicus

uniprot Q5RKP9 550
type: UnificationXref
id: Q5RKP9
db: uniprot

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P09215 137
organism: Rattus norvegicus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q6Z437 64
organism: Oryza sativa

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot P10687 654
organism: Rattus norvegicus

ncbitaxon 44689 232
type: UnificationXref
id: 44689
db: ncbitaxon

ACTIVE 76
type: EntityFeature
comment: Active state

Protein kinase C-like 1
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot P34722 147
organism: Caenorhabditis elegans

Endothelin-converting enzyme 1
type: ProteinReference
xref: uniprot P42892 517
xref: PTHR11733:SF130
organism: Homo sapiens

Endothelin-converting enzyme 1
type: ProteinReference
xref: uniprot P42893 518
xref: PTHR11733:SF130
organism: Rattus norvegicus

cGMP-dependent protein kinase
type: ProteinReference
xref: PTHR24353:SF132
xref: uniprot Q8I719 98
organism: Plasmodium falciparum

Endothelin-converting enzyme 1
type: ProteinReference
xref: uniprot P42891 516
xref: PTHR11733:SF130
organism: Bos taurus

uniprot P29474 423
type: UnificationXref
id: P29474
db: uniprot

uniprot E1BQN6 109
type: UnificationXref
id: E1BQN6
db: uniprot

uniprot H2QA34 408
type: UnificationXref
id: H2QA34
db: uniprot

uniprot Q08828 236
type: UnificationXref
id: Q08828
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7H3B3 125
xref: PTHR24356:SF162
organism: Macaca mulatta

Endothelin-converting enzyme-like 1
type: ProteinReference
xref: uniprot Q9JMI0 524
xref: PTHR11733:SF195
organism: Mus musculus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot H9EU39 130
organism: Macaca mulatta

Protein kinase A catalytic subunit isoform 2
type: ProteinReference
xref: uniprot E9AFM1 268
xref: PTHR24353:SF67
organism: Leishmania major

uniprot P22388 351
type: UnificationXref
id: P22388
db: uniprot

Guanylate cyclase soluble subunit beta-1
type: ProteinReference
xref: uniprot O54865 452
organism: Mus musculus

uniprot Q385V6 322
type: UnificationXref
id: Q385V6
db: uniprot

uniprot P30432 416
type: UnificationXref
id: P30432
db: uniprot

uniprot K7CDC2 592
type: UnificationXref
id: K7CDC2
db: uniprot

uniprot J9JHK9 651
type: UnificationXref
id: J9JHK9
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot F6ZAV4 194
xref: PTHR45627:SF6
organism: Ornithorhynchus anatinus

uniprot Q9M1Z5 73
type: UnificationXref
id: Q9M1Z5
db: uniprot

uniprot Q7KQK0 332
type: UnificationXref
id: Q7KQK0
db: uniprot

uniprot P00515 288
type: UnificationXref
id: P00515
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot F7G4Q0 278
organism: Monodelphis domestica

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MYJ4 582
xref: PTHR24356:SF190
organism: Bos taurus

uniprot Q63844 61
type: UnificationXref
id: Q63844
db: uniprot

uniprot A0A1D5PCI4 264
type: UnificationXref
id: A0A1D5PCI4
db: uniprot

uniprot E1BWA3 110
type: UnificationXref
id: E1BWA3
db: uniprot

Candida albicans
type: BioSource
xref: ncbitaxon 237561 59

uniprot P34885 148
type: UnificationXref
id: P34885
db: uniprot

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

uniprot P31751 595
type: UnificationXref
id: P31751
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot A0A1D5Q4D0 634
organism: Macaca mulatta

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot E2RJX4 580
organism: Canis lupus familiaris

uniprot F7G4Q0 278
type: UnificationXref
id: F7G4Q0
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 269

uniprot P21450 434
type: UnificationXref
id: P21450
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1Q4F8 584
xref: PTHR24356:SF190
organism: Canis lupus familiaris

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot A7F3M0 12
organism: Sclerotinia sclerotiorum

uniprot P27791 307
type: UnificationXref
id: P27791
db: uniprot

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 6

Prostaglandin G/H synthase 2
type: ProteinReference
xref: PTHR11903:SF8
xref: uniprot Q05769 471
organism: Mus musculus

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q04759 159
xref: PTHR24356:SF181
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot A0A3Q1MSP9 104
organism: Bos taurus

uniprot Q02156 157
type: UnificationXref
id: Q02156
db: uniprot

uniprot A0A3Q1MZN0 504
type: UnificationXref
id: A0A3Q1MZN0
db: uniprot

uniprot P33402 456
type: UnificationXref
id: P33402
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48014:SF24
xref: uniprot Q4QF64 325
organism: Leishmania major

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F7EBQ5 277
organism: Macaca mulatta

uniprot Q8MJ44 338
type: UnificationXref
id: Q8MJ44
db: uniprot

Endothelin converting enzyme 1
type: ProteinReference
xref: uniprot F1PK66 508
xref: PTHR11733:SF130
organism: Canis lupus familiaris

uniprot W4YRI6 342
type: UnificationXref
id: W4YRI6
db: uniprot

Adenylate cyclase type 5
type: ProteinReference
xref: PTHR45627:SF7
xref: uniprot Q04400 234
organism: Rattus norvegicus

Phospholipase A2
type: ProteinReference
evidence: Evidence 477
xref: uniprot H2Q0T0 482
xref: PTHR10728:SF13
organism: Pan troglodytes

uniprot F6TQN3 644
type: UnificationXref
id: F6TQN3
db: uniprot

PARTICIPANT STOICHIOMETRY re5 687
type: Stoichiometry
physical entity: Complex (ET-RA/B_endsub/Gs)
stoichiometric coefficient: 1.0

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF7
xref: uniprot E1BHU9 184
organism: Bos taurus

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 565
xref: uniprot P04049 564
xref: PTHR44329:SF22
organism: Homo sapiens

uniprot H2QSU0 619
type: UnificationXref
id: H2QSU0
db: uniprot

untitled
type: Pathway
pathway component: STATE_TRANSITION_LEFT__Adenylate_cyclase-RIGHT__Adenylate_cyclase-_re4
pathway component: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_re22
pathway component: DISSOCIATION_LEFT__GPL-RIGHT__LPL-_AA-_re3
pathway component: STATE_TRANSITION_LEFT__PLCbeta-RIGHT__PLCbeta-_re21
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re26
pathway component: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_re18
pathway component: DISSOCIATION_LEFT__L_Arg-RIGHT__L_Cit-_NO-_re2
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__PKG-RIGHT__PKG-_re9
pathway component: STATE_TRANSITION_LEFT__NSCC-RIGHT__NSCC-_re24
pathway component: TRUNCATION_LEFT__Pro_ET1_4-RIGHT__?-_Big_ET1_4-_re28
pathway component: STATE_TRANSITION_LEFT__IP3_R-RIGHT__IP3_R-_re15
pathway component: DISSOCIATION_LEFT__PIP2-RIGHT__IP3-_DAG-_re13
pathway component: STATE_TRANSITION_LEFT__AA-RIGHT__PGI2-_re20
pathway component: STATE_TRANSITION_LEFT__Guanylate_cyclase-RIGHT__Guanylate_cyclase-_re7
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__ET_RA_B_endsub_Gs_-_ET1_4-RIGHT__Complex__ET_RA_B_endsub_ET1_4_-_Gs-_re5
pathway component: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_re19
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re10
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re14
pathway component: STATE_TRANSITION_LEFT__cPLA2-RIGHT__cPLA2-_re16
pathway component: TRUNCATION_LEFT__Big_ET1_4-RIGHT__ET1_4-_?-_re29
pathway component: STATE_TRANSITION_LEFT__PI3_K-RIGHT__PI3_K-_re6
pathway component: TRUNCATION_LEFT__Pre_pro_ET1_4-RIGHT__?-_Pro_ET1_4-_re27
pathway component: STATE_TRANSITION_LEFT__Gq-RIGHT__Gq-_re23
pathway component: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re25
pathway component: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_re17
pathway component: STATE_TRANSITION_LEFT__eNOS-RIGHT__eNOS-_re1
pathway component: STATE_TRANSITION_LEFT__GTP-RIGHT__cGMP-_re8
pathway component: MODULATION
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re11
xref: PANTHER Pathway P00019 1
comment: MODEL_NOTES=

Gs
type: Protein
entity reference: Gs
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTGS2 isoform 1
type: ProteinReference
xref: PTHR11903:SF8
xref: uniprot H2Q0S9 466
organism: Pan troglodytes

uniprot H2RER5 284
type: UnificationXref
id: H2RER5
db: uniprot

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

uniprot P21708 38
type: UnificationXref
id: P21708
db: uniprot

GO GO:0005737 2
type: UnificationXref
id: GO:0005737
db: GO

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

Endothelin-2
type: ProteinReference
xref: uniprot P20800 349
xref: PTHR13874:SF9
organism: Homo sapiens

uniprot E7EXT6 581
type: UnificationXref
id: E7EXT6
db: uniprot

PARTICIPANT STOICHIOMETRY re5 690
type: Stoichiometry
physical entity: Gs
stoichiometric coefficient: 1.0

signal peptidase
type: Protein
entity reference: signal peptidase
comment: SPECIES_TYPE=PROTEIN

uniprot Q9VK52 256
type: UnificationXref
id: Q9VK52
db: uniprot

uniprot A0A2I3RQJ8 101
type: UnificationXref
id: A0A2I3RQJ8
db: uniprot

Guanylate cyclase soluble subunit alpha-2
type: ProteinReference
xref: uniprot Q9WVI4 464
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF24
xref: uniprot F7GTI6 83
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot A8WR64 106
organism: Caenorhabditis briggsae

PARTICIPANT STOICHIOMETRY re5 688
type: Stoichiometry
physical entity: ET1-4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 689
type: Stoichiometry
physical entity: Complex (ET-RA/B_endsub/ET1-4)
stoichiometric coefficient: 1.0

uniprot Q80TL1 242
type: UnificationXref
id: Q80TL1
db: uniprot

Complex (ET-RA/B_endsub/ET1-4)
type: Complex
component stoichiometry: ET1 4 s4 sa69 STOICHIOMETRY ID COMPLEX
component stoichiometry: ET RA B s3 sa68 STOICHIOMETRY ID COMPLEX
component: ET-RA/B
component: ET1-4
feature: COMPLEX BINDING FEATURE s58 csa2 675
feature: ACTIVE 76
feature: COMPLEX BINDING FEATURE s58 csa2 673
cellular location: cytoplasm

STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_re22
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 736
participant stoichiometry: PARTICIPANT STOICHIOMETRY re22 735
left: Akt
interaction type: STATE_TRANSITION
right: Akt

PRKACB isoform 3
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot H2R1G3 282
organism: Pan troglodytes

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

uniprot P21278 540
type: UnificationXref
id: P21278
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q7QK56 600
xref: PTHR24356:SF333
organism: Anopheles gambiae

Phospholipase A2
type: ProteinReference
evidence: Evidence 477
xref: uniprot F7CBU9 480
xref: PTHR10728:SF13
organism: Monodelphis domestica

Protein kinase C-like 3
type: ProteinReference
xref: uniprot Q19266 163
xref: PTHR24356:SF303
organism: Caenorhabditis elegans

uniprot Q9TUX8 426
type: UnificationXref
id: Q9TUX8
db: uniprot

PARTICIPANT STOICHIOMETRY re9 678
type: Stoichiometry
physical entity: PKG
stoichiometric coefficient: 1.0

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A2I3T9Y4 577
xref: PTHR24356:SF190
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re9 677
type: Stoichiometry
physical entity: PKG
stoichiometric coefficient: 1.0

uniprot P22612 305
type: UnificationXref
id: P22612
db: uniprot

Adenylate cyclase type 1
type: ProteinReference
xref: PTHR45627:SF12
xref: uniprot P19754 215
organism: Bos taurus

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 303
organism: Homo sapiens

Uncharacterized protein, isoform A
type: ProteinReference
xref: uniprot A1Z7R6 180
organism: Drosophila melanogaster

uniprot H2PYT1 398
type: UnificationXref
id: H2PYT1
db: uniprot

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

Furin
type: ProteinReference
xref: uniprot P23377 412
xref: PTHR42884:SF1
organism: Rattus norvegicus

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: uniprot F6T0T9 275
xref: PTHR24353:SF116
organism: Xenopus tropicalis

ET-RA/B
type: Protein
entity reference: ET-RA/B
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa66 670
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: uniprot Q14643 629
xref: PTHR13715:SF52
organism: Homo sapiens

uniprot P50392 486
type: UnificationXref
id: P50392
db: uniprot

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re25
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 730
participant stoichiometry: PARTICIPANT STOICHIOMETRY re25 729
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

ERK
type: Protein
entity reference: ERK
feature: ERK s29 sa59 rs2
feature: ERK s29 sa59 rs1
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re26
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 728
participant stoichiometry: PARTICIPANT STOICHIOMETRY re26 727
left: Ca2+
interaction type: TRANSPORT
right: Ca2+

uniprot E1B8P9 17
type: UnificationXref
id: E1B8P9
db: uniprot

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

GH23453p
type: ProteinReference
xref: uniprot Q961H2 249
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 709
participant stoichiometry: PARTICIPANT STOICHIOMETRY re14 710
left: PKC
interaction type: STATE_TRANSITION
right: PKC

uniprot Q5I0F6 326
type: UnificationXref
id: Q5I0F6
db: uniprot

PTHR16305:SF28
type: RelationshipXref
id: PTHR16305:SF28
db: PANTHER Family
relationship type: By Homology

uniprot F7BIC2 121
type: UnificationXref
id: F7BIC2
db: uniprot

uniprot Q04759 159
type: UnificationXref
id: Q04759
db: uniprot

uniprot Q7T374 335
type: UnificationXref
id: Q7T374
db: uniprot

uniprot O88444 213
type: UnificationXref
id: O88444
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F1LQT1 189
organism: Rattus norvegicus

Signal peptidase complex catalytic subunit SEC11A
type: ProteinReference
xref: PTHR10806:SF28
xref: uniprot P42667 384
organism: Rattus norvegicus

uniprot P70313 424
type: UnificationXref
id: P70313
db: uniprot

Adenylate cyclase type 9
type: ProteinReference
xref: uniprot O60503 212
xref: PTHR45627:SF8
organism: Homo sapiens

AGAP002441-PA
type: ProteinReference
xref: uniprot Q7QC43 522
organism: Anopheles gambiae

uniprot P36506 364
type: UnificationXref
id: P36506
db: uniprot

uniprot Q9DGG6 251
type: UnificationXref
id: Q9DGG6
db: uniprot

Dual specificity mitogen-activated protein kinase kinase mek-2
type: ProteinReference
xref: PTHR48013:SF19
xref: uniprot Q10664 369
organism: Caenorhabditis elegans

uniprot P36583 150
type: UnificationXref
id: P36583
db: uniprot

ncbitaxon 237561 59
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot P68404 154
type: UnificationXref
id: P68404
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 31

uniprot F8VQK3 451
type: UnificationXref
id: F8VQK3
db: uniprot

uniprot P09958 410
type: UnificationXref
id: P09958
db: uniprot

uniprot A0A0R4IY09 576
type: UnificationXref
id: A0A0R4IY09
db: uniprot

uniprot P13207 399
type: UnificationXref
id: P13207
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 554
evidence: Evidence 556
evidence: Evidence 555
evidence: Evidence 557
xref: uniprot A0A1D5R9U8 553
xref: PTHR44329:SF22
organism: Macaca mulatta

uniprot P23377 412
type: UnificationXref
id: P23377
db: uniprot

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: PTHR10806:SF28
xref: uniprot A0A1D5R670 376
organism: Macaca mulatta

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: uniprot P68182 317
xref: PTHR24353:SF116
organism: Rattus norvegicus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P68181 316
organism: Mus musculus

Endothelin-1 receptor
type: ProteinReference
xref: PTHR46099:SF2
xref: uniprot P25101 436
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY re13 712
type: Stoichiometry
physical entity: IP3
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot Q7KQK0 332
xref: PTHR11635:SF152
organism: Plasmodium falciparum

PARTICIPANT STOICHIOMETRY re13 711
type: Stoichiometry
physical entity: PIP2
stoichiometric coefficient: 1.0

uniprot Q9HEW1 341
type: UnificationXref
id: Q9HEW1
db: uniprot

PARTICIPANT STOICHIOMETRY re13 713
type: Stoichiometry
physical entity: DAG
stoichiometric coefficient: 1.0

ncbitaxon 7955 63
type: UnificationXref
id: 7955
db: ncbitaxon

Pro ET1-4
type: Protein
entity reference: Pro ET1-4
comment: SPECIES_TYPE=PROTEIN

uniprot F7ECA6 534
type: UnificationXref
id: F7ECA6
db: uniprot

Guanylate cyclase 1 soluble subunit alpha 2
type: ProteinReference
xref: uniprot F6Z2P2 449
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__GPL-RIGHT__LPL-_AA-_re3
controller: cPLA2

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q7ZUC5 172
organism: Danio rerio

uniprot O23236 33
type: UnificationXref
id: O23236
db: uniprot

GPL
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

uniprot F7GTI6 83
type: UnificationXref
id: F7GTI6
db: uniprot

Raf homolog serine/threonine-protein kinase Raf
type: ProteinReference
xref: uniprot P11346 571
organism: Drosophila melanogaster

Nitric oxide synthase, endothelial
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot P29474 423
organism: Homo sapiens

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 570
xref: uniprot P11345 569
xref: PTHR44329:SF22
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 717
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 716
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

uniprot Q02956 158
type: UnificationXref
id: Q02956
db: uniprot

Protein kinase A catalytic subunit
type: ProteinReference
xref: uniprot Q27687 321
xref: PTHR24353:SF37
organism: Leishmania major

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

NSCC
type: Protein
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P14681 35
type: UnificationXref
id: P14681
db: uniprot

Evidence 565
type: Evidence
evidence code: IGI
comment: SPACC P04049

uniprot Q05655 161
type: UnificationXref
id: Q05655
db: uniprot

uniprot H2QLZ4 618
type: UnificationXref
id: H2QLZ4
db: uniprot

uniprot P25101 436
type: UnificationXref
id: P25101
db: uniprot

Guanylate cyclase soluble subunit beta-2
type: ProteinReference
xref: PTHR45655:SF13
xref: uniprot P22717 455
organism: Rattus norvegicus

Protein kinase C
type: ProteinReference
xref: uniprot F6RA79 117
xref: PTHR24356:SF193
organism: Monodelphis domestica

uniprot Q14571 627
type: UnificationXref
id: Q14571
db: uniprot

uniprot Q5ZIF0 372
type: UnificationXref
id: Q5ZIF0
db: uniprot

uniprot A8XSS7 181
type: UnificationXref
id: A8XSS7
db: uniprot

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

ncbitaxon 6239 46
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot F7BCI5 196
type: UnificationXref
id: F7BCI5
db: uniprot

Evidence 575
type: Evidence
evidence code: IGI
comment: SPACC Q99N57

Evidence 570
type: Evidence
evidence code: IGI
comment: SPACC P11345

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9LMM5 71
organism: Arabidopsis thaliana

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF111
xref: uniprot A0A1D5PKL6 77
organism: Gallus gallus

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF1
xref: uniprot E1BQ12 186
organism: Bos taurus

uniprot F6Z2P2 449
type: UnificationXref
id: F6Z2P2
db: uniprot

Akt s30 sa22 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P35355 470
type: UnificationXref
id: P35355
db: uniprot

Adenylate cyclase type 3
type: ProteinReference
xref: uniprot P21932 216
xref: PTHR45627:SF13
organism: Rattus norvegicus

uniprot F6YKH9 81
type: UnificationXref
id: F6YKH9
db: uniprot

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P21137 304
xref: PTHR24353:SF117
organism: Caenorhabditis elegans

uniprot Q05769 471
type: UnificationXref
id: Q05769
db: uniprot

uniprot Q9VP76 258
type: UnificationXref
id: Q9VP76
db: uniprot

Endothelin-1 receptor
type: ProteinReference
xref: PTHR46099:SF2
xref: uniprot P26684 437
organism: Rattus norvegicus

uniprot P40146 222
type: UnificationXref
id: P40146
db: uniprot

Adenylate cyclase type 9
type: ProteinReference
xref: uniprot Q9DGG6 251
xref: PTHR45627:SF8
organism: Gallus gallus

uniprot G5ED52 510
type: UnificationXref
id: G5ED52
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF12
xref: uniprot D4A3N4 182
organism: Rattus norvegicus

Guanylate cyclase
type: ProteinReference
xref: P00581
standard name: guanylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Guanylate_br_cyclase
comment: ENTITY_REFERENCE_NOTES=Long Name: PLCbetaSynonym: Synonym not specifiedAccession: P00591
member entity reference: Guanylate cyclase 1, soluble, alpha 2
member entity reference: Uncharacterized protein
member entity reference: Receptor-type guanylate cyclase gcy-28
member entity reference: Guanylate cyclase soluble subunit alpha-1
member entity reference: Guanylate cyclase 1 soluble subunit alpha 2
member entity reference: GUCY1A3 isoform 1
member entity reference: Soluble guanylate cyclase gcy-36
member entity reference: GUCY1A2 isoform 2
member entity reference: Guanylate cyclase soluble subunit alpha-2
member entity reference: Receptor-type guanylate cyclase gcy-9
member entity reference: Soluble guanylate cyclase gcy-32
member entity reference: Guanylate cyclase soluble subunit beta-1
member entity reference: Guanylate cyclase soluble subunit beta-2
member entity reference: Guanylate cyclase 1 soluble subunit beta 1

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 9

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7G1U7 536
organism: Monodelphis domestica

PTHR13715:SF87
type: RelationshipXref
id: PTHR13715:SF87
db: PANTHER Family
relationship type: By Homology

Protein kinase, cAMP-dependent, catalytic, beta a
type: ProteinReference
xref: uniprot Q7T374 335
xref: PTHR24353:SF116
organism: Danio rerio

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P04627 566
organism: Mus musculus

PTHR11903:SF8
type: RelationshipXref
id: PTHR11903:SF8
db: PANTHER Family
relationship type: By Homology

ncbitaxon 5664 269
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot A0A2I3THL4 558
type: UnificationXref
id: A0A2I3THL4
db: uniprot

uniprot Q7ZVK8 67
type: UnificationXref
id: Q7ZVK8
db: uniprot

uniprot F6U0L7 509
type: UnificationXref
id: F6U0L7
db: uniprot

uniprot P11881 622
type: UnificationXref
id: P11881
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 555
xref: uniprot P05625 567
xref: PTHR44329:SF22
organism: Gallus gallus

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: uniprot E2RRD1 267
xref: PTHR11635:SF153
organism: Canis lupus familiaris

uniprot Q10N20 50
type: UnificationXref
id: Q10N20
db: uniprot

ncbitaxon 189518 337
type: UnificationXref
id: 189518
db: ncbitaxon

uniprot F7GEK1 590
type: UnificationXref
id: F7GEK1
db: uniprot

Protein kinase cAMP-dependent type I regulatory subunit alpha
type: ProteinReference
xref: uniprot F6R7N8 274
xref: PTHR11635:SF129
organism: Monodelphis domestica

Furin, paired basic amino acid cleaving enzyme
type: ProteinReference
xref: uniprot F7CEB1 406
xref: PTHR42884:SF1
organism: Xenopus tropicalis

Adenylate cyclase type 8
type: ProteinReference
xref: uniprot P97490 227
xref: PTHR45627:SF1
organism: Mus musculus

Protein kinase C iota type
type: ProteinReference
xref: uniprot P41743 151
xref: PTHR24356:SF214
organism: Homo sapiens

uniprot A0A1D5PKL6 77
type: UnificationXref
id: A0A1D5PKL6
db: uniprot

uniprot P22389 352
type: UnificationXref
id: P22389
db: uniprot

Ca2+
type: SmallMolecule
cellular location: endoplasmic reticulum
comment: SPECIES_TYPE=ION

Gq
type: Protein
entity reference: Gq
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Adenylate cyclase type 10
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot H2Q0J3 202
organism: Pan troglodytes

uniprot P39745 45
type: UnificationXref
id: P39745
db: uniprot

uniprot P22694 306
type: UnificationXref
id: P22694
db: uniprot

PGI2
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q03043 92
type: UnificationXref
id: Q03043
db: uniprot

uniprot A8WYC8 505
type: UnificationXref
id: A8WYC8
db: uniprot

uniprot F1QEC8 270
type: UnificationXref
id: F1QEC8
db: uniprot

uniprot Q39022 53
type: UnificationXref
id: Q39022
db: uniprot

uniprot Q24324 371
type: UnificationXref
id: Q24324
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot F7HC75 126
organism: Macaca mulatta

uniprot H9EU39 130
type: UnificationXref
id: H9EU39
db: uniprot

uniprot E2QY56 507
type: UnificationXref
id: E2QY56
db: uniprot

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot P12849 299
organism: Mus musculus

uniprot Q5TQX0 630
type: UnificationXref
id: Q5TQX0
db: uniprot

uniprot P14056 572
type: UnificationXref
id: P14056
db: uniprot

uniprot Q9Y243 605
type: UnificationXref
id: Q9Y243
db: uniprot

uniprot A0A1D5QMJ9 501
type: UnificationXref
id: A0A1D5QMJ9
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 70

cGMP-dependent protein kinase
type: ProteinReference
xref: PTHR24353:SF24
xref: uniprot H2QPS4 86
organism: Pan troglodytes

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot F6WM87 276
organism: Macaca mulatta

uniprot F6VT32 118
type: UnificationXref
id: F6VT32
db: uniprot

uniprot P23298 143
type: UnificationXref
id: P23298
db: uniprot

Mitogen-activated protein kinase mpk-1
type: ProteinReference
xref: uniprot P39745 45
xref: PTHR24055:SF158
organism: Caenorhabditis elegans

STATE_TRANSITION_LEFT__PI3_K-RIGHT__PI3_K-_re6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 684
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 683
left: PI3 K
interaction type: STATE_TRANSITION
right: PI3 K

PTHR10336:SF11
type: RelationshipXref
id: PTHR10336:SF11
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF12
type: RelationshipXref
id: PTHR10336:SF12
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F1P1X4 612
xref: PTHR13715:SF53
organism: Gallus gallus

PTHR10336:SF10
type: RelationshipXref
id: PTHR10336:SF10
db: PANTHER Family
relationship type: By Homology

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot F1MFR6 405
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF320
xref: uniprot F6PV18 491
organism: Macaca mulatta

ET RA B s1 sa66 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ET-RA/B
stoichiometric coefficient: 1.0

ncbitaxon 9544 9
type: UnificationXref
id: 9544
db: ncbitaxon

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 107

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q8UUX0 602
xref: PTHR24356:SF176
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 46

uniprot F7CEX4 197
type: UnificationXref
id: F7CEX4
db: uniprot

uniprot P04049 564
type: UnificationXref
id: P04049
db: uniprot

PTHR42884:SF23
type: RelationshipXref
id: PTHR42884:SF23
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
type: ProteinReference
xref: PTHR10336:SF11
xref: uniprot P51432 658
organism: Mus musculus

uniprot F6R543 613
type: UnificationXref
id: F6R543
db: uniprot

uniprot Q14643 629
type: UnificationXref
id: Q14643
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 554
evidence: Evidence 556
evidence: Evidence 555
evidence: Evidence 557
xref: uniprot E2REI6 560
xref: PTHR44329:SF22
organism: Canis lupus familiaris

Nitric oxide synthase
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot F6S3S1 421
organism: Monodelphis domestica

uniprot P81900 318
type: UnificationXref
id: P81900
db: uniprot

ET-RA/B
type: ProteinReference
xref: P00580
standard name: endothelin receptor A, B
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.RECEPTOR.ET_minus_R_sub_A_slash_B_endsub
comment: ENTITY_REFERENCE_NOTES=
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Endothelin-1 receptor
member entity reference: Endothelin receptor B subtype 2
member entity reference: Endothelin receptor type B
member entity reference: EDNRA isoform 2
member entity reference: Endothelin receptor type A
member entity reference: Endothelin-1 receptor isoform a
member entity reference: Uncharacterized protein
member entity reference: Endothelin receptor B

ncbitaxon 3702 34
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot H2QHJ5 204
type: UnificationXref
id: H2QHJ5
db: uniprot

uniprot P31750 594
type: UnificationXref
id: P31750
db: uniprot

uniprot H2Q832 203
type: UnificationXref
id: H2Q832
db: uniprot

uniprot F7BRK5 562
type: UnificationXref
id: F7BRK5
db: uniprot

ncbitaxon 9598 31
type: UnificationXref
id: 9598
db: ncbitaxon

G protein subunit alpha q
type: ProteinReference
xref: uniprot E1BA29 531
xref: PTHR10218:SF316
organism: Bos taurus

Guanine nucleotide-binding protein subunit alpha-11
type: ProteinReference
xref: PTHR10218:SF328
xref: uniprot A0A1D5QG31 528
organism: Macaca mulatta

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot E2R2N2 19
organism: Canis lupus familiaris

PTHR13874:SF9
type: RelationshipXref
id: PTHR13874:SF9
db: PANTHER Family
relationship type: By Homology

EDNRA isoform 2
type: ProteinReference
xref: PTHR46099:SF2
xref: uniprot H2QQ94 432
organism: Pan troglodytes

uniprot F6UQ33 479
type: UnificationXref
id: F6UQ33
db: uniprot

MODULATION
type: Control
xref: MODULATION
controlled: mitogenesis
controller: ERK

uniprot A8WR64 106
type: UnificationXref
id: A8WR64
db: uniprot

Ca(2+)/calmodulin-responsive adenylate cyclase
type: ProteinReference
xref: uniprot P32870 220
organism: Drosophila melanogaster

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 328

AGAP009315-PA (Fragment)
type: ProteinReference
xref: uniprot A0NC47 179
organism: Anopheles gambiae

Adenylate cyclase type 6
type: ProteinReference
xref: uniprot Q03343 233
xref: PTHR45627:SF11
organism: Rattus norvegicus

uniprot H2RDW0 493
type: UnificationXref
id: H2RDW0
db: uniprot

PTHR24353:SF132
type: RelationshipXref
id: PTHR24353:SF132
db: PANTHER Family
relationship type: By Homology

Protein kinase C iota type
type: ProteinReference
xref: uniprot Q90XF2 173
xref: PTHR24356:SF214
organism: Danio rerio

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot F6VT32 118
organism: Xenopus tropicalis

uniprot H9FU32 563
type: UnificationXref
id: H9FU32
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot C8V7D1 14
xref: PTHR24055:SF158
organism: Emericella nidulans

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q60823 599
organism: Mus musculus

uniprot Q13976 94
type: UnificationXref
id: Q13976
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot P11881 622
organism: Mus musculus

uniprot P87253 155
type: UnificationXref
id: P87253
db: uniprot

uniprot A0A0D1C4Y4 4
type: UnificationXref
id: A0A0D1C4Y4
db: uniprot

uniprot A0A3S5ZPX3 356
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

uniprot P36600 314
type: UnificationXref
id: P36600
db: uniprot

Raf 1 s71 sa35 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot Q5RI06 473
type: UnificationXref
id: Q5RI06
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot Q91UZ1 663
organism: Mus musculus

uniprot Q08462 235
type: UnificationXref
id: Q08462
db: uniprot

uniprot Q867A9 354
type: UnificationXref
id: Q867A9
db: uniprot

uniprot Q39026 56
type: UnificationXref
id: Q39026
db: uniprot

cAMP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
type: ProteinReference
xref: uniprot Q00722 659
xref: PTHR10336:SF10
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pre_pro_ET1_4-RIGHT__?-_Pro_ET1_4-_re27
controller: signal peptidase

Signal peptidase complex catalytic subunit SEC11A
type: ProteinReference
xref: PTHR10806:SF28
xref: uniprot P67810 385
organism: Bos taurus

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

ERK s68 sa50 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_ANGLE=3.17
comment: MODIFICATION_RESIDUE_NAME=

PTHR24353:SF129
type: RelationshipXref
id: PTHR24353:SF129
db: PANTHER Family
relationship type: By Homology

Prostaglandin G/H synthase 2
type: ProteinReference
xref: PTHR11903:SF8
xref: uniprot P27607 468
organism: Gallus gallus

Endothelin converting enzyme like 1
type: ProteinReference
xref: PTHR11733:SF195
xref: uniprot E2QY56 507
organism: Canis lupus familiaris

uniprot E1BA29 531
type: UnificationXref
id: E1BA29
db: uniprot

PTHR24353:SF111
type: RelationshipXref
id: PTHR24353:SF111
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P14056 572
organism: Rattus norvegicus

uniprot F1NYZ2 358
type: UnificationXref
id: F1NYZ2
db: uniprot

uniprot P51829 224
type: UnificationXref
id: P51829
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: uniprot F1M7Y5 113
xref: PTHR24356:SF214
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G1K7 535
xref: PTHR10218:SF316
organism: Monodelphis domestica

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q9M1Z5 73
organism: Arabidopsis thaliana

uniprot Q8CXT1 336
type: UnificationXref
id: Q8CXT1
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F7BIC2 121
organism: Macaca mulatta

uniprot Q8SPQ9 475
type: UnificationXref
id: Q8SPQ9
db: uniprot

ERK s68 sa50 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

P00574
type: UnificationXref
id: P00574
db: PANTHER Pathway Component

uniprot F7HC75 126
type: UnificationXref
id: F7HC75
db: uniprot

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05129 134
organism: Homo sapiens

P00575
type: UnificationXref
id: P00575
db: PANTHER Pathway Component

P00572
type: UnificationXref
id: P00572
db: PANTHER Pathway Component

cGMP-dependent protein kinase 2
type: ProteinReference
xref: uniprot Q61410 95
xref: PTHR24353:SF24
organism: Mus musculus

P00573
type: UnificationXref
id: P00573
db: PANTHER Pathway Component

uniprot A5WW41 396
type: UnificationXref
id: A5WW41
db: uniprot

P00570
type: UnificationXref
id: P00570
db: PANTHER Pathway Component

uniprot P49605 315
type: UnificationXref
id: P49605
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05126 132
organism: Bos taurus

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot A3KMS9 265
organism: Danio rerio

P00571
type: UnificationXref
id: P00571
db: PANTHER Pathway Component

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: uniprot P05128 133
xref: PTHR24356:SF162
organism: Bos taurus

uniprot B0JYR0 402
type: UnificationXref
id: B0JYR0
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F6QE96 585
organism: Macaca mulatta

ncbitaxon 227321 15
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot F7GJV6 344
type: UnificationXref
id: F7GJV6
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AA-RIGHT__PGI2-_re20
controller: COX-2

uniprot A0A1D5Q4D0 634
type: UnificationXref
id: A0A1D5Q4D0
db: uniprot

Phospholipase A2
type: ProteinReference
evidence: Evidence 477
xref: uniprot F7EEZ1 481
xref: PTHR10728:SF13
organism: Macaca mulatta

Adenylate cyclase
type: ProteinReference
xref: P00569
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: guanylate cyclaseSynonym: D2Mgh17,GTP pyrophosphate - lyase,guanylyl cyclaseAccession: P00581
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Adenylate_br_cyclase
member entity reference: AGAP003000-PA
member entity reference: Adenylate cyclase
member entity reference: Adenylyl CYclase
member entity reference: AGAP002262-PA
member entity reference: Adenylate cyclase type 6
member entity reference: Adenylate cyclase type 2
member entity reference: Adenylate cyclase type 10
member entity reference: Adenylate cyclase type 3
member entity reference: Adenylate cyclase type 7
member entity reference: GH23453p
member entity reference: AGAP009315-PA (Fragment)
member entity reference: ACXC, isoform A
member entity reference: Adenylate cyclase type 4
member entity reference: Adenylyl CYclase family member (Acy-1)-like
member entity reference: Adenylate cyclase type 1
member entity reference: Adenylate cyclase type 8
member entity reference: Adenylate cyclase 9
member entity reference: FI18259p1
member entity reference: Uncharacterized protein
member entity reference: ACXD, isoform A
member entity reference: FI20128p1
member entity reference: Adenylyl cyclase 35C, isoform C
member entity reference: Adenylate cyclase type 9
member entity reference: Adenylyl cyclase 78C
member entity reference: Ca(2+)/calmodulin-responsive adenylate cyclase
member entity reference: Adenylate cyclase type 5
member entity reference: Uncharacterized protein, isoform A
member entity reference: ACXA, isoform A
member entity reference: Protein CBR-ACY-1
member entity reference: IP12271p

uniprot Q9LQQ9 72
type: UnificationXref
id: Q9LQQ9
db: uniprot

FI20128p1
type: ProteinReference
xref: uniprot Q8INF8 244
organism: Drosophila melanogaster

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F1PRG4 583
organism: Canis lupus familiaris

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8
type: ProteinReference
xref: uniprot G5EBH0 647
xref: PTHR10336:SF106
organism: Caenorhabditis elegans

Adenylate cyclase
type: ProteinReference
xref: uniprot A0A1D5RHE7 177
xref: PTHR45627:SF6
organism: Macaca mulatta

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 488
xref: uniprot P50393 487
xref: PTHR10728:SF13
organism: Rattus norvegicus

uniprot P21137 304
type: UnificationXref
id: P21137
db: uniprot

P00569
type: UnificationXref
id: P00569
db: PANTHER Pathway Component

Cytosolic phospholipase A2
type: ProteinReference
xref: uniprot P50392 486
xref: PTHR10728:SF13
organism: Danio rerio

P00568
type: UnificationXref
id: P00568
db: PANTHER Pathway Component

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P20444 142
xref: PTHR24356:SF193
organism: Mus musculus

P00567
type: UnificationXref
id: P00567
db: PANTHER Pathway Component

P00566
type: UnificationXref
id: P00566
db: PANTHER Pathway Component

P00583
type: UnificationXref
id: P00583
db: PANTHER Pathway Component

P00584
type: UnificationXref
id: P00584
db: PANTHER Pathway Component

P00585
type: UnificationXref
id: P00585
db: PANTHER Pathway Component

P00586
type: UnificationXref
id: P00586
db: PANTHER Pathway Component

Raf 1 s71 sa35 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Adenylate cyclase type 5
type: ProteinReference
xref: PTHR45627:SF7
xref: uniprot P84309 226
organism: Mus musculus

P00580
type: UnificationXref
id: P00580
db: PANTHER Pathway Component

P00581
type: UnificationXref
id: P00581
db: PANTHER Pathway Component

P00582
type: UnificationXref
id: P00582
db: PANTHER Pathway Component

uniprot F6WM87 276
type: UnificationXref
id: F6WM87
db: uniprot

uniprot F7G1K7 535
type: UnificationXref
id: F7G1K7
db: uniprot

uniprot Q501R2 472
type: UnificationXref
id: Q501R2
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P05132 291
organism: Mus musculus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P05131 290
organism: Bos taurus

Protein kinase C, brain isozyme
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P05130 135
organism: Drosophila melanogaster

PTHR13715:SF52
type: RelationshipXref
id: PTHR13715:SF52
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase spk1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot P27638 42
organism: Schizosaccharomyces pombe

PTHR13715:SF51
type: RelationshipXref
id: PTHR13715:SF51
db: PANTHER Family
relationship type: By Homology

PTHR13715:SF53
type: RelationshipXref
id: PTHR13715:SF53
db: PANTHER Family
relationship type: By Homology

Leptospira interrogans
type: BioSource
xref: ncbitaxon 189518 337

Protein kinase C-like 2
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P36583 150
organism: Schizosaccharomyces pombe

ncbitaxon 6238 107
type: UnificationXref
id: 6238
db: ncbitaxon

Phosphoinositide phospholipase C (Fragment)
type: ProteinReference
xref: uniprot Q7PW25 662
organism: Anopheles gambiae

uniprot Q19523 237
type: UnificationXref
id: Q19523
db: uniprot

Protein kinase C-like 1
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P36582 149
organism: Schizosaccharomyces pombe

Signal peptidase I
type: ProteinReference
xref: uniprot Q9SSR2 393
xref: PTHR10806:SF6
organism: Arabidopsis thaliana

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P10398 568
organism: Homo sapiens

P00576
type: UnificationXref
id: P00576
db: PANTHER Pathway Component

P00578
type: UnificationXref
id: P00578
db: PANTHER Pathway Component

uniprot F7EEZ1 481
type: UnificationXref
id: F7EEZ1
db: uniprot

uniprot Q9NQ66 665
type: UnificationXref
id: Q9NQ66
db: uniprot

STATE_TRANSITION_LEFT__Adenylate_cyclase-RIGHT__Adenylate_cyclase-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 694
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 693
left: Adenylate cyclase
interaction type: STATE_TRANSITION
right: Adenylate cyclase

uniprot Q63803 497
type: UnificationXref
id: Q63803
db: uniprot

Protein CBG04739
type: ProteinReference
xref: uniprot A8WYC8 505
organism: Caenorhabditis briggsae

uniprot P05987 292
type: UnificationXref
id: P05987
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot F5HMB9 642
organism: Anopheles gambiae

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF12
xref: uniprot H2QUJ4 205
organism: Pan troglodytes

DISSOCIATION_LEFT__GPL-RIGHT__LPL-_AA-_re3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 697
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 699
participant stoichiometry: PARTICIPANT STOICHIOMETRY re3 698
left: GPL
interaction type: DISSOCIATION
right: AA
right: LPL

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot E2RRA1 266
organism: Canis lupus familiaris

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot Q9HEW1 341
organism: Candida albicans

uniprot F6QDY0 478
type: UnificationXref
id: F6QDY0
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot K7CDC2 592
organism: Pan troglodytes

uniprot A0A1D5Q5Z6 8
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

Phospholipase A2
type: ProteinReference
xref: uniprot F6QDY0 478
xref: PTHR10728:SF13
organism: Ornithorhynchus anatinus

uniprot Q7Q3B4 521
type: UnificationXref
id: Q7Q3B4
db: uniprot

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: PTHR10806:SF12
xref: uniprot Q2KI36 387
organism: Bos taurus

furin
type: ProteinReference
xref: P00575
standard name: Furin
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.furin
comment: ENTITY_REFERENCE_NOTES=Long Name: FurinSynonym: PACE,SPC1Accession: P00575
member entity reference: Furin
member entity reference: Neuroendocrine convertase 1
member entity reference: Furin, paired basic amino acid cleaving enzyme
member entity reference: PCSK1 isoform 2
member entity reference: Trans Golgi network protease furin
member entity reference: Furin-like protease 1, isoforms 1/1-X/2
member entity reference: Proprotein convertase subtilisin/kexin type 1
member entity reference: Furin-like protease 2
member entity reference: FURIN isoform 1

uniprot E2R2N2 19
type: UnificationXref
id: E2R2N2
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot Q8MJ44 338
organism: Canis lupus familiaris

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P13861 300
xref: PTHR11635:SF153
organism: Homo sapiens

uniprot P10687 654
type: UnificationXref
id: P10687
db: uniprot

uniprot E2RRA1 266
type: UnificationXref
id: E2RRA1
db: uniprot

ET1-4
type: Protein
entity reference: ET1-4
feature: ACTIVE 76
comment: SPECIES_TYPE=PROTEIN

cGMP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9LW08 390
type: UnificationXref
id: Q9LW08
db: uniprot

uniprot Q91WF3 248
type: UnificationXref
id: Q91WF3
db: uniprot

IP3
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P23188 411
type: UnificationXref
id: P23188
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63085 47
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: PTHR24351:SF182
xref: uniprot F1MDC9 114
organism: Bos taurus

Furin
type: ProteinReference
xref: uniprot G7MVY8 407
xref: PTHR42884:SF1
organism: Macaca mulatta

Mitogen-activated protein kinase 1
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot P63086 49
organism: Rattus norvegicus

uniprot F6XT65 360
type: UnificationXref
id: F6XT65
db: uniprot

uniprot Q9VAY0 525
type: UnificationXref
id: Q9VAY0
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot P26769 217
type: UnificationXref
id: P26769
db: uniprot

uniprot Q6DBV8 330
type: UnificationXref
id: Q6DBV8
db: uniprot

uniprot A0A3Q2U4X3 579
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

Adenylyl cyclase 35C, isoform C
type: ProteinReference
xref: uniprot M9PEP2 208
xref: PTHR45627:SF8
organism: Drosophila melanogaster

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O23236 33
organism: Arabidopsis thaliana

Adenylyl CYclase
type: ProteinReference
xref: uniprot O16880 209
xref: PTHR45627:SF25
organism: Caenorhabditis elegans

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot F6XMN6 119
organism: Canis lupus familiaris

uniprot F7A632 120
type: UnificationXref
id: F7A632
db: uniprot

uniprot H2Q0S9 466
type: UnificationXref
id: H2Q0S9
db: uniprot

Uncharacterized protein
type: ProteinReference
evidence: Evidence 554
evidence: Evidence 556
evidence: Evidence 555
evidence: Evidence 557
xref: uniprot F7BRK5 562
xref: PTHR44329:SF22
organism: Monodelphis domestica

P00587
type: UnificationXref
id: P00587
db: PANTHER Pathway Component

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q02750 367
xref: PTHR48013:SF5
organism: Homo sapiens

P00588
type: UnificationXref
id: P00588
db: PANTHER Pathway Component

P00589
type: UnificationXref
id: P00589
db: PANTHER Pathway Component

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: uniprot Q7PVR1 65
xref: PTHR24055:SF158
organism: Anopheles gambiae

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__IP3_R-RIGHT__IP3_R-_re15
controller: IP3

Prostaglandin G/H synthase 2
type: ProteinReference
xref: uniprot O62698 467
xref: PTHR11903:SF8
organism: Bos taurus

uniprot P04627 566
type: UnificationXref
id: P04627
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot K7BA21 652
xref: PTHR10336:SF12
organism: Pan troglodytes

P00591
type: UnificationXref
id: P00591
db: PANTHER Pathway Component

P00590
type: UnificationXref
id: P00590
db: PANTHER Pathway Component

uniprot H2QSB1 345
type: UnificationXref
id: H2QSB1
db: uniprot

AGAP007796-PA
type: ProteinReference
xref: uniprot Q7Q3B4 521
organism: Anopheles gambiae

uniprot Q5ZM91 329
type: UnificationXref
id: Q5ZM91
db: uniprot

cGMP-dependent protein kinase
type: ProteinReference
xref: PTHR24353:SF129
xref: uniprot A0A2R8Q8R8 79
organism: Danio rerio

uniprot Q7PWT0 97
type: UnificationXref
id: Q7PWT0
db: uniprot

ncbitaxon 10090 48
type: UnificationXref
id: 10090
db: ncbitaxon

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q05655 161
organism: Homo sapiens

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF129
xref: uniprot Q9DBC7 339
organism: Mus musculus

uniprot Q22523 519
type: UnificationXref
id: Q22523
db: uniprot

uniprot F6R7N8 274
type: UnificationXref
id: F6R7N8
db: uniprot

uniprot E7EAU8 448
type: UnificationXref
id: E7EAU8
db: uniprot

TRIGGER
type: Control
xref: TRIGGER
controlled: TRANSPORT_LEFT__Ca2_PLUS_-RIGHT__Ca2_PLUS_-_re26
control type: ACTIVATION
controller: NSCC

uniprot A0A3Q2U0G2 637
type: UnificationXref
id: A0A3Q2U0G2
db: uniprot

uniprot P32870 220
type: UnificationXref
id: P32870
db: uniprot

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: uniprot Q17941 598
xref: PTHR24356:SF333
organism: Caenorhabditis elegans

Neprilysin-3
type: ProteinReference
xref: uniprot Q9W5Y0 527
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY re28 721
type: Stoichiometry
physical entity: Pro ET1-4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 723
type: Stoichiometry
physical entity: Big ET1-4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re28 722
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKG-RIGHT__PKG-_re9
controller: cGMP

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: PTHR10336:SF106
xref: uniprot H9FVW1 649
organism: Macaca mulatta

Adenylate cyclase
type: ProteinReference
xref: uniprot F6V001 193
xref: PTHR45627:SF6
organism: Monodelphis domestica

uniprot Q9XT09 375
type: UnificationXref
id: Q9XT09
db: uniprot

G protein subunit alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot Q5EAP4 548
organism: Rattus norvegicus

uniprot P27638 42
type: UnificationXref
id: P27638
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot F1MJV4 190
organism: Bos taurus

uniprot P12370 298
type: UnificationXref
id: P12370
db: uniprot

uniprot Q03101 231
type: UnificationXref
id: Q03101
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: uniprot A8KBH6 105
xref: PTHR24356:SF158
organism: Xenopus tropicalis

uniprot Q9QW07 666
type: UnificationXref
id: Q9QW07
db: uniprot

V-akt murine thymoma viral oncogene homolog 2,-like
type: ProteinReference
xref: uniprot A0A0R4IY09 576
organism: Danio rerio

uniprot Q9BY50 388
type: UnificationXref
id: Q9BY50
db: uniprot

Signal peptidase complex catalytic subunit SEC11A
type: ProteinReference
xref: PTHR10806:SF28
xref: uniprot P67812 386
organism: Homo sapiens

Endothelin-1
type: ProteinReference
xref: uniprot P22387 350
xref: PTHR13874:SF10
organism: Mus musculus

Endothelin-1
type: ProteinReference
xref: PTHR13874:SF10
xref: uniprot P22388 351
organism: Rattus norvegicus

Endothelin-2
type: ProteinReference
xref: uniprot P22389 352
organism: Mus musculus

uniprot F6THW2 532
type: UnificationXref
id: F6THW2
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot Q14573 628
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot Q14571 627
xref: PTHR13715:SF53
organism: Homo sapiens

Phosphoinositide phospholipase C
type: ProteinReference
xref: uniprot Q9XWB7 667
organism: Caenorhabditis elegans

uniprot Q02153 458
type: UnificationXref
id: Q02153
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q5ZIF0 372
organism: Gallus gallus

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36507 365
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot P36506 364
xref: PTHR48013:SF8
organism: Rattus norvegicus

Receptor-type guanylate cyclase gcy-9
type: ProteinReference
xref: uniprot E7EAU8 448
organism: Caenorhabditis elegans

cPLA2
type: Protein
entity reference: cPLA2
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Protein kinase C
type: ProteinReference
xref: uniprot F7BYI4 122
xref: PTHR24356:SF158
organism: Macaca mulatta

Protein kinase C
type: ProteinReference
xref: uniprot Q7QCP8 169
xref: PTHR24356:SF240
organism: Anopheles gambiae

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot Q2KI36 387
type: UnificationXref
id: Q2KI36
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot H2QJY5 648
xref: PTHR10336:SF106
organism: Pan troglodytes

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

uniprot H2R1G3 282
type: UnificationXref
id: H2R1G3
db: uniprot

uniprot Q9V9R3 252
type: UnificationXref
id: Q9V9R3
db: uniprot

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 15

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: PTHR10336:SF12
xref: uniprot Q9NQ66 665
organism: Homo sapiens

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

uniprot O16880 209
type: UnificationXref
id: O16880
db: uniprot

Protein Kinase, cGMP-dependent
type: ProteinReference
xref: uniprot H2KYN2 84
organism: Caenorhabditis elegans

uniprot P26016 413
type: UnificationXref
id: P26016
db: uniprot

Prostaglandin-endoperoxide synthase 2a
type: ProteinReference
xref: uniprot Q6P4V3 474
xref: PTHR11903:SF8
organism: Danio rerio

uniprot P50148 546
type: UnificationXref
id: P50148
db: uniprot

PARTICIPANT STOICHIOMETRY re16 701
type: Stoichiometry
physical entity: cPLA2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re16 700
type: Stoichiometry
physical entity: cPLA2
stoichiometric coefficient: 1.0

ncbitaxon 7227 91
type: UnificationXref
id: 7227
db: ncbitaxon

uniprot F6VQP7 615
type: UnificationXref
id: F6VQP7
db: uniprot

uniprot P63085 47
type: UnificationXref
id: P63085
db: uniprot

uniprot P68181 316
type: UnificationXref
id: P68181
db: uniprot

uniprot Q03042 90
type: UnificationXref
id: Q03042
db: uniprot

PARTICIPANT STOICHIOMETRY re18 691
type: Stoichiometry
physical entity: Raf-1
stoichiometric coefficient: 1.0

uniprot F1PRG4 583
type: UnificationXref
id: F1PRG4
db: uniprot

PARTICIPANT STOICHIOMETRY re18 692
type: Stoichiometry
physical entity: Raf-1
stoichiometric coefficient: 1.0

uniprot Q9VW60 259
type: UnificationXref
id: Q9VW60
db: uniprot

uniprot F7G1U7 536
type: UnificationXref
id: F7G1U7
db: uniprot

Evidence 488
type: Evidence
evidence code: IGI
comment: SPACC P50393

PTHR45816:SF3
type: RelationshipXref
id: PTHR45816:SF3
db: PANTHER Family
relationship type: By Homology

COX-2
type: Protein
entity reference: COX-2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9JHL3 523
type: UnificationXref
id: Q9JHL3
db: uniprot

uniprot Q6P4V3 474
type: UnificationXref
id: Q6P4V3
db: uniprot

Guanylate cyclase soluble subunit alpha-2
type: ProteinReference
xref: uniprot P33402 456
organism: Homo sapiens

PLCbeta
type: Protein
entity reference: PLCbeta
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q6Z437 64
type: UnificationXref
id: Q6Z437
db: uniprot

ECE1-3
type: Protein
entity reference: ECE1-3
comment: SPECIES_TYPE=PROTEIN

uniprot A0A3Q1LSD1 420
type: UnificationXref
id: A0A3Q1LSD1
db: uniprot

eNOS
type: ProteinReference
xref: P00578
standard name: endothelial cell nitric oxide synthase
comment: ENTITY_REFERENCE_NOTES=Long Name: endothelial cell nitric oxide synthaseSynonym: nitric oxide synthase 3Accession: P00578
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.eNOS
member entity reference: Nitric oxide synthase, endothelial
member entity reference: Nitric oxide synthase

Furin
type: ProteinReference
xref: uniprot P09958 410
xref: PTHR42884:SF1
organism: Homo sapiens

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot H2QLZ4 618
xref: PTHR13715:SF53
organism: Pan troglodytes

Prostaglandin G/H synthase 2b
type: ProteinReference
xref: uniprot Q5RI06 473
organism: Danio rerio

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q7ZVK8 67
organism: Danio rerio

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 36

uniprot P05771 136
type: UnificationXref
id: P05771
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot H2QSU0 619
organism: Pan troglodytes

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 91

uniprot Q02108 457
type: UnificationXref
id: Q02108
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11733:SF127
xref: uniprot F6U0L7 509
organism: Macaca mulatta

Gs s2 sa67 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Gs
stoichiometric coefficient: 1.0

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: uniprot Q63269 631
xref: PTHR13715:SF51
organism: Rattus norvegicus

uniprot E2RRD1 267
type: UnificationXref
id: E2RRD1
db: uniprot

Endothelin-converting enzyme-like 1
type: ProteinReference
xref: uniprot O95672 513
xref: PTHR11733:SF195
organism: Homo sapiens

Mitogen-activated protein kinase KSS1
type: ProteinReference
xref: uniprot P14681 35
organism: Saccharomyces cerevisiae

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: smooth muscle cell contraction
controller: PKA

Adenylate cyclase
type: ProteinReference
xref: uniprot E2RCX6 188
xref: PTHR45627:SF1
organism: Canis lupus familiaris

Guanine nucleotide-binding protein (G protein), alpha 14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot Q66JF0 551
organism: Xenopus tropicalis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Gq-RIGHT__Gq-_re23
controller: Complex (ET-RA/B_endsub/ET1-4)

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 99

uniprot P51432 658
type: UnificationXref
id: P51432
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF13
xref: uniprot A0A1D5QMQ7 176
organism: Macaca mulatta

STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_re18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 692
participant stoichiometry: PARTICIPANT STOICHIOMETRY re18 691
left: Raf-1
interaction type: STATE_TRANSITION
right: Raf-1

uniprot Q8C0T9 243
type: UnificationXref
id: Q8C0T9
db: uniprot

PARTICIPANT STOICHIOMETRY re23 733
type: Stoichiometry
physical entity: Gq
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re23 734
type: Stoichiometry
physical entity: Gq
stoichiometric coefficient: 1.0

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF13
xref: uniprot H2QHJ5 204
organism: Pan troglodytes

uniprot F1PXS7 21
type: UnificationXref
id: F1PXS7
db: uniprot

uniprot H2Q8F2 127
type: UnificationXref
id: H2Q8F2
db: uniprot

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q66JE6 374
xref: PTHR48013:SF5
organism: Xenopus tropicalis

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q6P023 62
xref: PTHR24055:SF203
organism: Danio rerio

uniprot P9WQ35 228
type: UnificationXref
id: P9WQ35
db: uniprot

Adenylate cyclase type 10
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot Q96PN6 250
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZCW7 616
xref: PTHR13715:SF53
organism: Monodelphis domestica

CAP family transcription factor
type: ProteinReference
xref: PTHR11635:SF157
xref: uniprot Q8CXT1 336
organism: Leptospira interrogans

uniprot A0A2I3SK46 178
type: UnificationXref
id: A0A2I3SK46
db: uniprot

DAG
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__cPLA2-RIGHT__cPLA2-_re16
controller: Ca2+

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P23298 143
organism: Mus musculus

uniprot Q7Q042 168
type: UnificationXref
id: Q7Q042
db: uniprot

Adenylate cyclase type 6
type: ProteinReference
xref: uniprot O43306 210
xref: PTHR45627:SF11
organism: Homo sapiens

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 27

uniprot Q5JWF2 496
type: UnificationXref
id: Q5JWF2
db: uniprot

uniprot O95672 513
type: UnificationXref
id: O95672
db: uniprot

uniprot K7CYN2 207
type: UnificationXref
id: K7CYN2
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9LQQ9 72
organism: Arabidopsis thaliana

TRIGGER
type: RelationshipTypeVocabulary

uniprot H2Q0J3 202
type: UnificationXref
id: H2Q0J3
db: uniprot

Soluble guanylate cyclase gcy-32
type: ProteinReference
xref: uniprot Q6DNF7 460
organism: Caenorhabditis elegans

Soluble guanylate cyclase gcy-36
type: ProteinReference
xref: uniprot Q6DNF4 459
organism: Caenorhabditis elegans

uniprot A0A2I3T8F7 635
type: UnificationXref
id: A0A2I3T8F7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F1PL90 640
xref: PTHR10336:SF12
organism: Canis lupus familiaris

uniprot P36507 365
type: UnificationXref
id: P36507
db: uniprot

PARTICIPANT STOICHIOMETRY re29 720
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

PLCbeta
type: Protein
entity reference: PLCbeta
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P47197 597
type: UnificationXref
id: P47197
db: uniprot

PARTICIPANT STOICHIOMETRY re29 718
type: Stoichiometry
physical entity: Big ET1-4
stoichiometric coefficient: 1.0

Signal peptidase complex catalytic subunit SEC11A
type: ProteinReference
xref: PTHR10806:SF28
xref: uniprot Q9R0P6 392
organism: Mus musculus

PARTICIPANT STOICHIOMETRY re29 719
type: Stoichiometry
physical entity: ET1-4
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot Q8IRF5 245
organism: Drosophila melanogaster

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P30625 308
organism: Caenorhabditis elegans

uniprot A0A3Q2UCL4 427
type: UnificationXref
id: A0A3Q2UCL4
db: uniprot

uniprot P21932 216
type: UnificationXref
id: P21932
db: uniprot

L-Cit
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=ION

Prostaglandin-endoperoxide synthase 2
type: ProteinReference
xref: uniprot Q501R2 472
organism: Xenopus tropicalis

Gq
type: Protein
entity reference: Gq
feature: ACTIVE 76
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Protein kinase C
type: ProteinReference
xref: uniprot E1BMG4 108
xref: PTHR24356:SF181
organism: Bos taurus

uniprot M9PEP2 208
type: UnificationXref
id: M9PEP2
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P24723 145
organism: Homo sapiens

eco ECO:0000316 6
type: UnificationXref
id: ECO:0000316
db: eco

Adenylate cyclase 9
type: ProteinReference
xref: PTHR45627:SF8
xref: uniprot F7CEX4 197
organism: Xenopus tropicalis

Guanylate cyclase
type: Protein
entity reference: Guanylate cyclase
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Endothelin-2
type: ProteinReference
xref: uniprot P23943 353
xref: PTHR13874:SF9
organism: Rattus norvegicus

uniprot F6SD46 643
type: UnificationXref
id: F6SD46
db: uniprot

Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot Q6NW93 331
organism: Danio rerio

cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B
type: ProteinReference
xref: uniprot Q03043 92
organism: Drosophila melanogaster

ncbitaxon 185431 323
type: UnificationXref
id: 185431
db: ncbitaxon

cGMP-dependent protein kinase, isozyme 1
type: ProteinReference
xref: uniprot Q03042 90
organism: Drosophila melanogaster

Dual specificity mitogen-activated protein kinase kinase dSOR1
type: ProteinReference
xref: PTHR48013:SF19
xref: uniprot Q24324 371
organism: Drosophila melanogaster

IP12271p
type: ProteinReference
xref: uniprot Q1EC10 238
organism: Drosophila melanogaster

uniprot Q7PVR1 65
type: UnificationXref
id: Q7PVR1
db: uniprot

uniprot F7AQR3 533
type: UnificationXref
id: F7AQR3
db: uniprot

Endothelin-1 receptor
type: ProteinReference
xref: PTHR46099:SF2
xref: uniprot P21450 434
organism: Bos taurus

uniprot Q0VD16 368
type: UnificationXref
id: Q0VD16
db: uniprot

Evidence 477
type: Evidence
evidence code: ISS
comment: SPACC P50393

uniprot Q5Z859 60
type: UnificationXref
id: Q5Z859
db: uniprot

uniprot Q7PGR0 240
type: UnificationXref
id: Q7PGR0
db: uniprot

uniprot H2QPS4 86
type: UnificationXref
id: H2QPS4
db: uniprot

uniprot Q6P023 62
type: UnificationXref
id: Q6P023
db: uniprot

eNOS
type: Protein
entity reference: eNOS
feature: eNOS s32 sa30 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

cAMP-dependent protein kinase type I-alpha regulatory subunit
type: ProteinReference
xref: uniprot Q5ZM91 329
xref: PTHR11635:SF129
organism: Gallus gallus

Nitric oxide synthase, endothelial
type: ProteinReference
xref: PTHR19384:SF66
xref: uniprot Q62600 425
organism: Rattus norvegicus

uniprot A3KMS9 265
type: UnificationXref
id: A3KMS9
db: uniprot

uniprot F7E689 450
type: UnificationXref
id: F7E689
db: uniprot

uniprot P34099 313
type: UnificationXref
id: P34099
db: uniprot

Gs
type: ProteinReference
xref: P00584
standard name: stimulatory G protein
comment: ENTITY_REFERENCE_NOTES=Long Name: stimulatory G proteinSynonym: guanine nucleotide binding protein s polypeptideAccession: P00584
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.G_sub_s
member entity reference: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
member entity reference: Uncharacterized protein
member entity reference: G protein, Subunit Alpha
member entity reference: Guanine nucleotide-binding protein G(olf) subunit alpha
member entity reference: G protein alpha s subunit

uniprot P47196 596
type: UnificationXref
id: P47196
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 3
type: ProteinReference
xref: PTHR13715:SF51
xref: uniprot E2RMC0 610
organism: Canis lupus familiaris

TRUNCATION_LEFT__Pre_pro_ET1_4-RIGHT__?-_Pro_ET1_4-_re27
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 724
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 725
participant stoichiometry: PARTICIPANT STOICHIOMETRY re27 726
left: Pre-pro ET1-4
interaction type: TRUNCATION
right: Pro ET1-4
right: ?

Inositol 1,4,5-trisphosphate receptor type 2
type: ProteinReference
xref: uniprot A0A3Q1N7P8 607
xref: PTHR45816:SF3
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re10 717
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

uniprot F7HUD3 201
type: UnificationXref
id: F7HUD3
db: uniprot

PTHR48013:SF19
type: RelationshipXref
id: PTHR48013:SF19
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY re10 716
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31751 595
xref: PTHR24356:SF176
organism: Homo sapiens

uniprot Q13237 93
type: UnificationXref
id: Q13237
db: uniprot

Ca2+
type: SmallMolecule
comment: SPECIES_TYPE=ION

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 594
organism: Mus musculus

PTHR24356:SF240
type: RelationshipXref
id: PTHR24356:SF240
db: PANTHER Family
relationship type: By Homology

ncbitaxon 7668 343
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot Q39021 52
type: UnificationXref
id: Q39021
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 18

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9WUA6 603
xref: PTHR24356:SF190
organism: Mus musculus

uniprot F1P1X4 612
type: UnificationXref
id: F1P1X4
db: uniprot

NEPrilysin metallopeptidase family
type: ProteinReference
xref: uniprot G5ED52 510
organism: Caenorhabditis elegans

uniprot P67812 386
type: UnificationXref
id: P67812
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PI3_K-RIGHT__PI3_K-_re6
controller: Gs

Adenylyl cyclase 78C
type: ProteinReference
xref: uniprot Q9VP76 258
xref: PTHR45627:SF1
organism: Drosophila melanogaster

COX-2
type: ProteinReference
xref: P00582
standard name: cyclooxygenase-2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: cyclooxygenase-2Synonym: Synonym not specifiedAccession: P00582
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.COX_minus_2
member entity reference: Prostaglandin G/H synthase 2
member entity reference: Prostaglandin-endoperoxide synthase 2a
member entity reference: Uncharacterized protein
member entity reference: Cyclooxygenase 2
member entity reference: Prostaglandin G/H synthase 2b
member entity reference: PTGS2 isoform 1
member entity reference: Prostaglandin-endoperoxide synthase 2

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31749 593
organism: Homo sapiens

uniprot A0A2I3SSC7 606
type: UnificationXref
id: A0A2I3SSC7
db: uniprot

MEK s70 sa49 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot A0A2I3RJ55 502
type: UnificationXref
id: A0A2I3RJ55
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
type: ProteinReference
xref: uniprot P10894 655
xref: PTHR10336:SF12
organism: Bos taurus

Endothelin-converting enzyme 1
type: ProteinReference
xref: uniprot Q4PZA2 520
xref: PTHR11733:SF130
organism: Mus musculus

uniprot P12369 297
type: UnificationXref
id: P12369
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QMJ9 501
xref: PTHR11733:SF130
organism: Macaca mulatta

uniprot Q8I719 98
type: UnificationXref
id: Q8I719
db: uniprot

uniprot H2QVM2 422
type: UnificationXref
id: H2QVM2
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31324 312
organism: Mus musculus

PIP2
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Cytosolic phospholipase A2
type: ProteinReference
xref: uniprot P49147 485
xref: PTHR10728:SF13
organism: Gallus gallus

uniprot Q9JID2 552
type: UnificationXref
id: Q9JID2
db: uniprot

G protein alpha s subunit
type: ProteinReference
xref: PTHR10218:SF212
xref: uniprot P20354 494
organism: Drosophila melanogaster

uniprot Q4PZA2 520
type: UnificationXref
id: Q4PZA2
db: uniprot

uniprot P12849 299
type: UnificationXref
id: P12849
db: uniprot

MEK s70 sa49 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot A8KBH6 105
type: UnificationXref
id: A8KBH6
db: uniprot

GH26575p
type: ProteinReference
xref: uniprot Q9VH96 526
organism: Drosophila melanogaster

Adenylate cyclase type 10
type: ProteinReference
xref: PTHR16305:SF28
xref: uniprot Q8C0T9 243
organism: Mus musculus

PTHR24356:SF214
type: RelationshipXref
id: PTHR24356:SF214
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3SR38 102
xref: PTHR24356:SF181
organism: Pan troglodytes

uniprot Q99N57 574
type: UnificationXref
id: Q99N57
db: uniprot

uniprot F6RCU6 588
type: UnificationXref
id: F6RCU6
db: uniprot

cGMP-dependent protein kinase 1
type: ProteinReference
xref: uniprot P0C605 89
xref: PTHR24353:SF68
organism: Mus musculus

uniprot F7DL70 199
type: UnificationXref
id: F7DL70
db: uniprot

eco ECO:0000250 10
type: UnificationXref
id: ECO:0000250
db: eco

ET1-4
type: Protein
entity reference: ET1-4
feature: ACTIVE 76
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa69 676
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F1PK66 508
type: UnificationXref
id: F1PK66
db: uniprot

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: uniprot P12370 298
xref: PTHR24353:SF117
organism: Drosophila melanogaster

uniprot H2Q1X0 85
type: UnificationXref
id: H2Q1X0
db: uniprot

Endothelin-2
type: ProteinReference
xref: uniprot Q867A9 354
organism: Bos taurus

RAC serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q8INB9 601
xref: PTHR24356:SF333
organism: Drosophila melanogaster

uniprot P20800 349
type: UnificationXref
id: P20800
db: uniprot

Endothelin-1 receptor
type: ProteinReference
xref: uniprot Q61614 442
xref: PTHR46099:SF2
organism: Mus musculus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31323 311
organism: Homo sapiens

cAMP-dependent protein kinase type I-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF126
xref: uniprot P31321 310
organism: Homo sapiens

uniprot P51828 223
type: UnificationXref
id: P51828
db: uniprot

uniprot Q9XTG7 604
type: UnificationXref
id: Q9XTG7
db: uniprot

Adenylate cyclase type 8
type: ProteinReference
xref: uniprot P40146 222
xref: PTHR45627:SF1
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot P30677 543
organism: Mus musculus

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 78

Uncharacterized protein
type: ProteinReference
xref: PTHR46099:SF4
xref: uniprot A0A3Q2UCL4 427
organism: Gallus gallus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P12369 297
organism: Rattus norvegicus

uniprot Q7KPV0 499
type: UnificationXref
id: Q7KPV0
db: uniprot

uniprot A0A1D5QGM1 419
type: UnificationXref
id: A0A1D5QGM1
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12367 295
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P12368 296
xref: PTHR11635:SF153
organism: Rattus norvegicus

DISSOCIATION_LEFT__L_Arg-RIGHT__L_Cit-_NO-_re2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 702
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 704
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 703
left: L-Arg
interaction type: DISSOCIATION
right: NO
right: L-Cit

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q5PU49 165
xref: PTHR24356:SF365
organism: Canis lupus familiaris

Inositol 1,4,5-trisphosphate receptor type 1 isoform 3
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot H9FU38 621
organism: Macaca mulatta

uniprot F6ZKL2 646
type: UnificationXref
id: F6ZKL2
db: uniprot

Adenylate cyclase type 8
type: ProteinReference
xref: uniprot P40145 221
xref: PTHR45627:SF1
organism: Homo sapiens

Endothelin 1
type: ProteinReference
xref: uniprot A5WW41 396
xref: PTHR13874:SF10
organism: Danio rerio

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot H9FU32 563
organism: Macaca mulatta

uniprot H2QFK0 280
type: UnificationXref
id: H2QFK0
db: uniprot

uniprot Q8VHH7 247
type: UnificationXref
id: Q8VHH7
db: uniprot

uniprot P50393 487
type: UnificationXref
id: P50393
db: uniprot

uniprot Q86GV3 461
type: UnificationXref
id: Q86GV3
db: uniprot

uniprot Q08C49 320
type: UnificationXref
id: Q08C49
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
type: ProteinReference
xref: uniprot F1PLB3 641
xref: PTHR10336:SF106
organism: Canis lupus familiaris

uniprot V5IKE7 74
type: UnificationXref
id: V5IKE7
db: uniprot

PARTICIPANT STOICHIOMETRY re19 686
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

uniprot F7HSF3 431
type: UnificationXref
id: F7HSF3
db: uniprot

PARTICIPANT STOICHIOMETRY re19 685
type: Stoichiometry
physical entity: MEK
stoichiometric coefficient: 1.0

uniprot P05128 133
type: UnificationXref
id: P05128
db: uniprot

uniprot A0A1D5RHE7 177
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

uniprot F7BWZ9 465
type: UnificationXref
id: F7BWZ9
db: uniprot

vaso-relaxation
type: Pathway

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 715
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 714
left: PKA
interaction type: STATE_TRANSITION
right: PKA

PARTICIPANT STOICHIOMETRY re26 727
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re26 728
type: Stoichiometry
physical entity: Ca2+
stoichiometric coefficient: 1.0

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__NSCC-RIGHT__NSCC-_re24
controller: Complex (ET-RA/B_endsub/ET1-4)

uniprot A0A3Q1NH21 578
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

uniprot A0A2I3TRC4 529
type: UnificationXref
id: A0A2I3TRC4
db: uniprot

uniprot Q91000 418
type: UnificationXref
id: Q91000
db: uniprot

uniprot E2RMC0 610
type: UnificationXref
id: E2RMC0
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot E1BQN6 109
organism: Gallus gallus

Guanine nucleotide-binding protein subunit alpha-14
type: ProteinReference
xref: PTHR10218:SF213
xref: uniprot F7AQR3 533
organism: Macaca mulatta

uniprot Q64617 167
type: UnificationXref
id: Q64617
db: uniprot

Adenylate cyclase type 5
type: ProteinReference
xref: uniprot O95622 214
xref: PTHR45627:SF7
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR13874:SF9
xref: uniprot F7GJV6 344
organism: Macaca mulatta

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot P49605 315
organism: Ustilago maydis

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: PTHR10806:SF28
xref: uniprot A0A2I3T2V8 378
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6R8N3 587
xref: PTHR24356:SF190
organism: Macaca mulatta

uniprot Q9SSR2 393
type: UnificationXref
id: Q9SSR2
db: uniprot

uniprot P35354 469
type: UnificationXref
id: P35354
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: uniprot H2Q8F2 127
xref: PTHR24356:SF192
organism: Pan troglodytes

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 477
xref: uniprot P47712 483
xref: PTHR10728:SF13
organism: Homo sapiens

Cytosolic phospholipase A2
type: ProteinReference
evidence: Evidence 477
xref: uniprot P47713 484
xref: PTHR10728:SF13
organism: Mus musculus

uniprot P13206 347
type: UnificationXref
id: P13206
db: uniprot

Signal peptidase complex catalytic subunit SEC11C
type: ProteinReference
xref: PTHR10806:SF12
xref: uniprot Q9BY50 388
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q2UD13 608
xref: PTHR13715:SF52
organism: Gallus gallus

uniprot Q7QCP8 169
type: UnificationXref
id: Q7QCP8
db: uniprot

Neprilysin-21
type: ProteinReference
xref: uniprot Q22523 519
organism: Caenorhabditis elegans

uniprot P11345 569
type: UnificationXref
id: P11345
db: uniprot

ET-RA/B
type: Protein
entity reference: ET-RA/B
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa68 674
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 51

STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_re19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 686
participant stoichiometry: PARTICIPANT STOICHIOMETRY re19 685
left: MEK
interaction type: STATE_TRANSITION
right: MEK

ATP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Endothelin receptor B
type: ProteinReference
xref: PTHR46099:SF3
xref: uniprot Q9DGM2 443
organism: Danio rerio

uniprot A0A2J8MUU7 447
type: UnificationXref
id: A0A2J8MUU7
db: uniprot

PARTICIPANT STOICHIOMETRY re14 710
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

ERK
type: Protein
entity reference: ERK
feature: ERK s68 sa50 rs1
feature: ERK s68 sa50 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P28867 146
organism: Mus musculus

uniprot Q6DNF4 459
type: UnificationXref
id: Q6DNF4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF316
xref: uniprot Q5F3B5 549
organism: Gallus gallus

Adenylate cyclase
type: ProteinReference
xref: uniprot P9WQ35 228
organism: Mycobacterium tuberculosis

Adenylate cyclase type 6
type: ProteinReference
xref: PTHR45627:SF11
xref: uniprot Q01341 230
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: uniprot F7A632 120
xref: PTHR24356:SF158
organism: Monodelphis domestica

uniprot G5EBH0 647
type: UnificationXref
id: G5EBH0
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot H2RER5 284
organism: Pan troglodytes

uniprot H2KYN2 84
type: UnificationXref
id: H2KYN2
db: uniprot

Adenylyl CYclase
type: ProteinReference
xref: uniprot Q19523 237
xref: PTHR45627:SF8
organism: Caenorhabditis elegans

uniprot Q5J7U3 441
type: UnificationXref
id: Q5J7U3
db: uniprot

uniprot P11346 571
type: UnificationXref
id: P11346
db: uniprot

PTHR24353:SF67
type: RelationshipXref
id: PTHR24353:SF67
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF68
type: RelationshipXref
id: PTHR24353:SF68
db: PANTHER Family
relationship type: By Homology

uniprot P13861 300
type: UnificationXref
id: P13861
db: uniprot

uniprot P67810 385
type: UnificationXref
id: P67810
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot F7H582 200
xref: PTHR45627:SF11
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK-RIGHT__MEK-_re19
controller: Raf-1

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF12
xref: uniprot F7HUD3 201
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RKF6 444
organism: Macaca mulatta

Neuroendocrine convertase 1
type: ProteinReference
xref: uniprot P28840 414
organism: Rattus norvegicus

uniprot Q66JF0 551
type: UnificationXref
id: Q66JF0
db: uniprot

uniprot Q9VK50 254
type: UnificationXref
id: Q9VK50
db: uniprot

uniprot P05129 134
type: UnificationXref
id: P05129
db: uniprot

uniprot K7BYT0 362
type: UnificationXref
id: K7BYT0
db: uniprot

uniprot P30625 308
type: UnificationXref
id: P30625
db: uniprot

Furin
type: ProteinReference
xref: uniprot B0JYR0 402
xref: PTHR42884:SF1
organism: Bos taurus

Akt s79 sa24 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P15367 383
type: UnificationXref
id: P15367
db: uniprot

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

uniprot O16789 512
type: UnificationXref
id: O16789
db: uniprot

uniprot K7BA21 652
type: UnificationXref
id: K7BA21
db: uniprot

uniprot F7E823 24
type: UnificationXref
id: F7E823
db: uniprot

ncbitaxon 9606 41
type: UnificationXref
id: 9606
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5PCI4 264
xref: PTHR11635:SF126
organism: Gallus gallus

ncbitaxon 665079 13
type: UnificationXref
id: 665079
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PLCbeta-RIGHT__PLCbeta-_re21
controller: Gq

uniprot P13677 139
type: UnificationXref
id: P13677
db: uniprot

PTHR48014:SF24
type: RelationshipXref
id: PTHR48014:SF24
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_ET1_4-RIGHT__?-_Big_ET1_4-_re28
controller: furin

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

Adenylyl CYclase family member (Acy-1)-like
type: ProteinReference
xref: PTHR45627:SF8
xref: uniprot E1BM79 185
organism: Bos taurus

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 43

AGAP002262-PA
type: ProteinReference
xref: uniprot Q7QKC3 241
organism: Anopheles gambiae

uniprot Q5EAP4 548
type: UnificationXref
id: Q5EAP4
db: uniprot

uniprot E2RJX4 580
type: UnificationXref
id: E2RJX4
db: uniprot

uniprot F1MYJ4 582
type: UnificationXref
id: F1MYJ4
db: uniprot

uniprot F1LQT1 189
type: UnificationXref
id: F1LQT1
db: uniprot

PTHR24353:SF24
type: RelationshipXref
id: PTHR24353:SF24
db: PANTHER Family
relationship type: By Homology

Protein kinase C-like
type: ProteinReference
xref: PTHR24356:SF390
xref: uniprot P87253 155
organism: Neurospora crassa

uniprot Q7ZUC5 172
type: UnificationXref
id: Q7ZUC5
db: uniprot

uniprot F6ZAV4 194
type: UnificationXref
id: F6ZAV4
db: uniprot

ET1 4 s4 sa69 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ET1-4
stoichiometric coefficient: 1.0

uniprot Q8INB9 601
type: UnificationXref
id: Q8INB9
db: uniprot

Endothelin-3
type: ProteinReference
xref: uniprot P14138 400
organism: Homo sapiens

MODULATION
type: Control
xref: MODULATION
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_re14
controller: Ca2+

FI18259p1
type: ProteinReference
xref: uniprot Q9VY22 260
organism: Drosophila melanogaster

uniprot Q9R0P6 392
type: UnificationXref
id: Q9R0P6
db: uniprot

Inositol 1,4,5-trisphosphate receptor type 1
type: ProteinReference
xref: PTHR13715:SF52
xref: uniprot F1MX21 611
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HAK5 279
xref: PTHR11635:SF153
organism: Macaca mulatta

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 343

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: PTHR11635:SF152
xref: uniprot O59922 286
organism: Emericella nidulans

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q84UI5 68
organism: Oryza sativa

cGMP-dependent protein kinase 1
type: ProteinReference
xref: uniprot Q13976 94
xref: PTHR24353:SF68
organism: Homo sapiens

ET RA B s3 sa68 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ET-RA/B
stoichiometric coefficient: 1.0

Signal peptidase complex catalytic subunit SEC11C
type: ProteinReference
xref: uniprot Q9WTR7 394
xref: PTHR10806:SF12
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK-RIGHT__ERK-_re17
controller: MEK

smooth muscle cell contraction
type: Pathway

uniprot F7G3L7 82
type: UnificationXref
id: F7G3L7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot V5IKE7 74
organism: Neurospora crassa

uniprot H2QDQ1 129
type: UnificationXref
id: H2QDQ1
db: uniprot

uniprot F7HAK5 279
type: UnificationXref
id: F7HAK5
db: uniprot

uniprot A0A2I3RI58 445
type: UnificationXref
id: A0A2I3RI58
db: uniprot

uniprot P47712 483
type: UnificationXref
id: P47712
db: uniprot

Raf homolog serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q07292 573
organism: Caenorhabditis elegans

AGAP001384-PA
type: ProteinReference
xref: uniprot Q7PXF7 334
xref: PTHR24353:SF117
organism: Anopheles gambiae

uniprot P05132 291
type: UnificationXref
id: P05132
db: uniprot

uniprot P30804 219
type: UnificationXref
id: P30804
db: uniprot

Endothelin-1 receptor isoform a
type: ProteinReference
xref: PTHR46099:SF2
xref: uniprot F7HSF3 431
organism: Macaca mulatta

uniprot Q5F3B5 549
type: UnificationXref
id: Q5F3B5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F6S9S9 359
organism: Monodelphis domestica

AGAP008863-PA
type: ProteinReference
xref: uniprot Q7PWT0 97
organism: Anopheles gambiae

Protein kinase C
type: ProteinReference
xref: uniprot Q7T2C5 171
xref: PTHR24356:SF158
organism: Danio rerio

uniprot Q01986 366
type: UnificationXref
id: Q01986
db: uniprot

uniprot A0A1D5QG31 528
type: UnificationXref
id: A0A1D5QG31
db: uniprot

uniprot Q8NFM4 246
type: UnificationXref
id: Q8NFM4
db: uniprot

uniprot P17252 141
type: UnificationXref
id: P17252
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot A0A1D5QUZ8 11
organism: Macaca mulatta

uniprot A1Z7R6 180
type: UnificationXref
id: A1Z7R6
db: uniprot

PTHR45627:SF9
type: RelationshipXref
id: PTHR45627:SF9
db: PANTHER Family
relationship type: By Homology

PTHR45655:SF13
type: RelationshipXref
id: PTHR45655:SF13
db: PANTHER Family
relationship type: By Homology

PTHR45627:SF7
type: RelationshipXref
id: PTHR45627:SF7
db: PANTHER Family
relationship type: By Homology

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

PTHR45627:SF8
type: RelationshipXref
id: PTHR45627:SF8
db: PANTHER Family
relationship type: By Homology

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q9WTQ0 174
organism: Rattus norvegicus

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 232

PTHR45627:SF1
type: RelationshipXref
id: PTHR45627:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q63269 631
type: UnificationXref
id: Q63269
db: uniprot

PARTICIPANT STOICHIOMETRY re17 696
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

cAMP-dependent protein kinase regulatory subunit
type: ProteinReference
xref: uniprot P36600 314
xref: PTHR11635:SF152
organism: Schizosaccharomyces pombe

uniprot F1MPC9 191
type: UnificationXref
id: F1MPC9
db: uniprot

PARTICIPANT STOICHIOMETRY re17 695
type: Stoichiometry
physical entity: ERK
stoichiometric coefficient: 1.0

Furin-like protease 1, isoforms 1/1-X/2
type: ProteinReference
xref: PTHR42884:SF3
xref: uniprot P26016 413
organism: Drosophila melanogaster

Pre-pro ET1-4
type: ProteinReference
xref: P00576
standard name: Pre-pro endothelin 1, 2, 3, and 4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Pre-pro endothelin 1, 2, 3, and 4Synonym: Synonym not specifiedAccession: P00576
comment: ENTITY_REFERENCE_ID_DESC=untitled.PROTEIN.GENERIC.Pre_minus_pro_br_ET1_minus_4
member entity reference: Endothelin-2
member entity reference: Endothelin-1
member entity reference: EDN1 isoform 1
member entity reference: Uncharacterized protein

uniprot E2RNP2 112
type: UnificationXref
id: E2RNP2
db: uniprot

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 323

Endothelin receptor type A
type: ProteinReference
xref: PTHR46099:SF2
xref: uniprot Q5J7U3 441
organism: Canis lupus familiaris

uniprot F7EG64 124
type: UnificationXref
id: F7EG64
db: uniprot

L-Arg
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Evidence 557
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

ncbitaxon 3055 70
type: UnificationXref
id: 3055
db: ncbitaxon

Evidence 555
type: Evidence
evidence code: ISS
comment: SPACC P05625

uniprot F1PL90 640
type: UnificationXref
id: F1PL90
db: uniprot

Evidence 556
type: Evidence
evidence code: ISS
comment: SPACC P11345

Evidence 554
type: Evidence
evidence code: ISS
comment: SPACC P04049

Furin
type: ProteinReference
xref: uniprot P23188 411
xref: PTHR42884:SF1
organism: Mus musculus

uniprot P00517 289
type: UnificationXref
id: P00517
db: uniprot

uniprot K7CBH8 131
type: UnificationXref
id: K7CBH8
db: uniprot

uniprot Q90XF2 173
type: UnificationXref
id: Q90XF2
db: uniprot

EGL-30
type: ProteinReference
xref: uniprot G5EGU1 537
xref: PTHR10218:SF329
organism: Caenorhabditis elegans

uniprot P16054 140
type: UnificationXref
id: P16054
db: uniprot

uniprot H2QR92 409
type: UnificationXref
id: H2QR92
db: uniprot

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
type: ProteinReference
xref: uniprot Q5JWF2 496
organism: Homo sapiens

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q05513 160
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QLB4 30
xref: PTHR24055:SF203
organism: Pan troglodytes

Big ET1-4
type: Protein
entity reference: Big ET1-4
comment: SPECIES_TYPE=PROTEIN

uniprot F7DVL1 123
type: UnificationXref
id: F7DVL1
db: uniprot

Akt
type: Protein
entity reference: Akt
feature: Akt s30 sa22 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

AGAP012252-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q042 168
xref: PTHR24356:SF390
organism: Anopheles gambiae

PTHR11920:SF488
type: RelationshipXref
id: PTHR11920:SF488
db: PANTHER Family
relationship type: By Homology

PTHR11920:SF487
type: RelationshipXref
id: PTHR11920:SF487
db: PANTHER Family
relationship type: By Homology

uniprot F7EBQ5 277
type: UnificationXref
id: F7EBQ5
db: uniprot

uniprot E1BM79 185
type: UnificationXref
id: E1BM79
db: uniprot

uniprot P12368 296
type: UnificationXref
id: P12368
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot A0A1D5Q5Z6 8
organism: Macaca mulatta

uniprot P63319 153
type: UnificationXref
id: P63319
db: uniprot

STATE_TRANSITION_LEFT__eNOS-RIGHT__eNOS-_re1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 707
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 708
left: eNOS
interaction type: STATE_TRANSITION
right: eNOS

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P17252 141
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot A0A2R8QJ48 103
organism: Danio rerio

STATE_TRANSITION
type: InteractionVocabulary

Signal peptidase complex catalytic subunit SEC11
type: ProteinReference
xref: PTHR10806:SF6
xref: uniprot O97066 381
organism: Drosophila melanogaster

TRANSPORT
type: InteractionVocabulary

uniprot Q8CGK7 500
type: UnificationXref
id: Q8CGK7
db: uniprot

PRKACG isoform 1
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot H2QXB9 281
organism: Pan troglodytes

uniprot Q64595 96
type: UnificationXref
id: Q64595
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re10
controller: Adenylate cyclase

uniprot E1BMG4 108
type: UnificationXref
id: E1BMG4
db: uniprot

NEPrilysin metallopeptidase family
type: ProteinReference
xref: uniprot O16789 512
organism: Caenorhabditis elegans

uniprot F7CEB1 406
type: UnificationXref
id: F7CEB1
db: uniprot

uniprot A0A3Q1N7P8 607
type: UnificationXref
id: A0A3Q1N7P8
db: uniprot

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: uniprot Q5A1D3 58
xref: PTHR24055:SF158
organism: Candida albicans

uniprot H2R3M7 283
type: UnificationXref
id: H2R3M7
db: uniprot

uniprot Q62074 166
type: UnificationXref
id: Q62074
db: uniprot

uniprot Q60823 599
type: UnificationXref
id: Q60823
db: uniprot

uniprot Q00722 659
type: UnificationXref
id: Q00722
db: uniprot

Adenylate cyclase
type: ProteinReference
xref: uniprot F7DL70 199
xref: PTHR45627:SF9
organism: Macaca mulatta

uniprot P19754 215
type: UnificationXref
id: P19754
db: uniprot

Trans Golgi network protease furin
type: ProteinReference
xref: uniprot Q91000 418
xref: PTHR42884:SF1
organism: Gallus gallus

uniprot P16892 37
type: UnificationXref
id: P16892
db: uniprot

PARTICIPANT STOICHIOMETRY re20 740
type: Stoichiometry
physical entity: PGI2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re20 739
type: Stoichiometry
physical entity: AA
stoichiometric coefficient: 1.0

uniprot A0A2J8QDF6 636
type: UnificationXref
id: A0A2J8QDF6
db: uniprot

uniprot F7CBU9 480
type: UnificationXref
id: F7CBU9
db: uniprot

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 23

uniprot F6XP81 589
type: UnificationXref
id: F6XP81
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7FQJ7 397
xref: PTHR13874:SF11
organism: Macaca mulatta

uniprot Q9WUA6 603
type: UnificationXref
id: Q9WUA6
db: uniprot

uniprot O73739 433
type: UnificationXref
id: O73739
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
type: ProteinReference
xref: uniprot P25455 657
organism: Drosophila melanogaster

uniprot F6S3S1 421
type: UnificationXref
id: F6S3S1
db: uniprot

PARTICIPANT STOICHIOMETRY re14 709
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot P16905 301
type: UnificationXref
id: P16905
db: uniprot

uniprot Q9N3D0 391
type: UnificationXref
id: Q9N3D0
db: uniprot

uniprot Q7QC43 522
type: UnificationXref
id: Q7QC43
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__cPLA2-RIGHT__cPLA2-_re16
controller: ERK