AC
type: ProteinReference
xref: P05978
standard name: adenylate cyclase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Enkephalin release.PROTEIN.GENERIC.AC
comment: ENTITY_REFERENCE_NOTES=Long Name: adenylate cyclase Synonym: Long Name: AC,adenylate cyclase,adenylate cyclase 2,adenylate cyclase 7,adenylyl cyclase Accession: P05978
member entity reference: Adenylate cyclase
member entity reference: Adenylate cyclase type 7
member entity reference: Adenylate cyclase type 2

uniprot Q61011 180
type: UnificationXref
id: Q61011
db: uniprot

G protein subunit alpha i3
type: ProteinReference
xref: uniprot H2PZK9 308
xref: PTHR10218:SF230
organism: Pan troglodytes

uniprot P05131 249
type: UnificationXref
id: P05131
db: uniprot

uniprot P38405 134
type: UnificationXref
id: P38405
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q5ZJ03 179
organism: Gallus gallus

PTHR10218:SF331
type: RelationshipXref
id: PTHR10218:SF331
db: PANTHER Family
relationship type: By Homology

AC
type: Protein
entity reference: AC
feature: ACTIVE 283
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

G protein subunit alpha i1
type: ProteinReference
xref: uniprot F1P977 299
xref: PTHR10218:SF227
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PUU3 20
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IFL6 43
organism: Bos taurus

uniprot F7CDR6 9
type: UnificationXref
id: F7CDR6
db: uniprot

uniprot H2RER5 243
type: UnificationXref
id: H2RER5
db: uniprot

Adenylate cyclase type 2
type: ProteinReference
xref: PTHR45627:SF6
xref: uniprot Q08462 346
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63212 155
organism: Bos taurus

uniprot P32300 288
type: UnificationXref
id: P32300
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 16

PRKACB isoform 3
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot H2R1G3 242
organism: Pan troglodytes

ncbitaxon 6238 227
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot F1R4H8 212
type: UnificationXref
id: F1R4H8
db: uniprot

Delta-type opioid receptor
type: ProteinReference
xref: uniprot P33533 289
xref: PTHR24229:SF2
organism: Rattus norvegicus

uniprot F7G4Q0 237
type: UnificationXref
id: F7G4Q0
db: uniprot

uniprot Q6R0H7 190
type: UnificationXref
id: Q6R0H7
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62879 150
organism: Homo sapiens

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P17612 257
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62874 149
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62872 147
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62873 148
organism: Homo sapiens

uniprot P18851 124
type: UnificationXref
id: P18851
db: uniprot

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot P62881 152
organism: Mus musculus

PTHR10218:SF310
type: RelationshipXref
id: PTHR10218:SF310
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P62880 151
organism: Mus musculus

Protein kinase cAMP-activated catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F6T0T9 235
organism: Xenopus tropicalis

uniprot P29829 130
type: UnificationXref
id: P29829
db: uniprot

uniprot Q5ZJ03 179
type: UnificationXref
id: Q5ZJ03
db: uniprot

Proenkephalin a
type: ProteinReference
xref: uniprot A8E7S2 211
xref: PTHR11438:SF3
organism: Danio rerio

uniprot P31323 262
type: UnificationXref
id: P31323
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 73

Gnai3 protein
type: ProteinReference
xref: uniprot A9JTC8 295
xref: PTHR10218:SF230
organism: Danio rerio

G-Protein (i)
type: Protein
entity reference: G-Protein (i)
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa7 356
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F6WNJ9 303
organism: Xenopus tropicalis

CREB s20 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P62871 146
organism: Bos taurus

PTHR10218:SF320
type: RelationshipXref
id: PTHR10218:SF320
db: PANTHER Family
relationship type: By Homology

Adenylate cyclase
type: ProteinReference
xref: uniprot F1LQT1 337
xref: PTHR45627:SF9
organism: Rattus norvegicus

uniprot Q1LZH5 35
type: UnificationXref
id: Q1LZH5
db: uniprot

Cyclic AMP-responsive element-binding protein 1 isoform B
type: ProteinReference
xref: uniprot F6Z7F5 25
xref: PTHR45879:SF1
organism: Macaca mulatta

uniprot F6WNJ9 303
type: UnificationXref
id: F6WNJ9
db: uniprot

uniprot E9H7Z0 298
type: UnificationXref
id: E9H7Z0
db: uniprot

uniprot H9EQQ4 245
type: UnificationXref
id: H9EQQ4
db: uniprot

uniprot Q9DAS9 204
type: UnificationXref
id: Q9DAS9
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot F7CTP1 93
organism: Macaca mulatta

uniprot A7EDU2 46
type: UnificationXref
id: A7EDU2
db: uniprot

Guanine nucleotide binding protein, beta 3
type: ProteinReference
xref: uniprot Q5XGD8 178
organism: Xenopus tropicalis

uniprot H2Q9G5 110
type: UnificationXref
id: H2Q9G5
db: uniprot

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 18

uniprot Q28H40 170
type: UnificationXref
id: Q28H40
db: uniprot

uniprot F6PV18 76
type: UnificationXref
id: F6PV18
db: uniprot

uniprot F7G3J2 101
type: UnificationXref
id: F7G3J2
db: uniprot

Complex (GTP/G-Protein)
type: Complex
component stoichiometry: GTP s1 sa1 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s s6 sa2 STOICHIOMETRY ID COMPLEX
component: GTP
component: G-Protein (s)
feature: ACTIVE 283
feature: COMPLEX BINDING FEATURE s2 a2 361
feature: COMPLEX BINDING FEATURE s2 a2 359
cellular location: cytosol

Guanine nucleotide-binding protein G(O) subunit alpha 1
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot E9H7Z0 298
organism: Daphnia pulex

uniprot P01210 218
type: UnificationXref
id: P01210
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P68182 267
organism: Rattus norvegicus

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P68181 266
organism: Mus musculus

preproenkephalin
type: DnaRegionReference
member entity reference: Proenkephalin-B
member entity reference: Proenkephalin-A
member entity reference: Proenkephalin a
member entity reference: Prodynorphin
member entity reference: Beta-neoendorphin-dynorphin
member entity reference: Proenkephalin
member entity reference: PDYN isoform 1
member entity reference: PENK isoform 3
xref: G06045
comment: ENTITY_REFERENCE_ID_DESC=Enkephalin release.GENE.GENE.preproenkephalin
comment: ENTITY_REFERENCE_NOTES=Long Name: preproenkephalin Synonym: Synonym not specified Accession: G06045

Enkephalin
type: ProteinReference
xref: P05976
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Enkephalin Synonym: Long Name: Enkephalin Accession: P05976
comment: ENTITY_REFERENCE_ID_DESC=Enkephalin release.PROTEIN.GENERIC.Enkephalin
member entity reference: Prodynorphin
member entity reference: Beta-neoendorphin-dynorphin
member entity reference: PENK isoform 3
member entity reference: Proenkephalin
member entity reference: Proenkephalin-B
member entity reference: Proenkephalin-A
member entity reference: Proenkephalin a
member entity reference: PDYN isoform 1

uniprot P63097 324
type: UnificationXref
id: P63097
db: uniprot

ncbitaxon 6669 64
type: UnificationXref
id: 6669
db: ncbitaxon

uniprot P50150 138
type: UnificationXref
id: P50150
db: uniprot

Guanine nucleotide-binding protein subunit beta-5a
type: ProteinReference
xref: uniprot A1L271 42
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot C3ZSF0 50
organism: Branchiostoma floridae

uniprot P06300 222
type: UnificationXref
id: P06300
db: uniprot

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot Q6TNT8 328
organism: Danio rerio

uniprot P63215 158
type: UnificationXref
id: P63215
db: uniprot

uniprot Q0VFC4 164
type: UnificationXref
id: Q0VFC4
db: uniprot

uniprot P00515 247
type: UnificationXref
id: P00515
db: uniprot

Protein kinase A catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q27687 269
organism: Leishmania major

uniprot K7ADQ0 342
type: UnificationXref
id: K7ADQ0
db: uniprot

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa3 368
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F5HH30 72
type: UnificationXref
id: F5HH30
db: uniprot

G-Protein (i)
type: Protein
entity reference: G-Protein (i)
feature: COMPLEX PARTICIPANT BINDING FEATURE s19 sa10 352
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot K7AE17 115
type: UnificationXref
id: K7AE17
db: uniprot

Proenkephalin-A
type: DnaReference
xref: PTHR11438:SF3
organism: Rattus norvegicus

uniprot Q6TH03 191
type: UnificationXref
id: Q6TH03
db: uniprot

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Pain relief Analgesia via binding to opioid receptor
controller: Enkephalin

Proenkephalin-A
type: ProteinReference
xref: uniprot P04094 221
xref: PTHR11438:SF3
organism: Rattus norvegicus

uniprot Q80SZ7 200
type: UnificationXref
id: Q80SZ7
db: uniprot

G protein subunit beta 1
type: ProteinReference
xref: uniprot F6PGC8 74
organism: Ornithorhynchus anatinus

uniprot Q61017 182
type: UnificationXref
id: Q61017
db: uniprot

ncbitaxon 7955 4
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot H2PZA6 107
type: UnificationXref
id: H2PZA6
db: uniprot

uniprot Q5XGD8 178
type: UnificationXref
id: Q5XGD8
db: uniprot

Opioid receptor, delta 1a
type: ProteinReference
xref: uniprot A3QJX7 284
xref: PTHR24229:SF2
organism: Danio rerio

GPCR (i)
type: ProteinReference
xref: P05973
standard name: Gi protein coupled receptor
comment: ENTITY_REFERENCE_NOTES= Long Name: GPCR (i) Synonym: G-Protein coupled receptor,Long Name: GPCR (i) Accession: P05973
comment: ENTITY_REFERENCE_ID_DESC=Enkephalin release.PROTEIN.RECEPTOR.GPCR (i)
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Delta-type opioid receptor
member entity reference: Opioid receptor delta 1
member entity reference: Opioid receptor, delta 1a
member entity reference: OPRD1 isoform 1
member entity reference: Uncharacterized protein

Guanine nucleotide-binding protein G(olf) subunit alpha
type: ProteinReference
xref: uniprot Q8CGK7 201
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R9G5 59
organism: Canis lupus familiaris

uniprot Q7SX83 36
type: UnificationXref
id: Q7SX83
db: uniprot

uniprot F7CXD0 94
type: UnificationXref
id: F7CXD0
db: uniprot

Guanine nucleotide-binding protein subunit beta-5
type: ProteinReference
xref: uniprot O14775 118
organism: Homo sapiens

uniprot Q7Q5C3 195
type: UnificationXref
id: Q7Q5C3
db: uniprot

CREB
type: ProteinReference
xref: P05971
standard name: cAMP response element binding protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: cAMP response element binding protein Synonym: Long Name: CREB Accession: P05971
comment: ENTITY_REFERENCE_ID_DESC=Enkephalin release.PROTEIN.GENERIC.CREB
member entity reference: cAMP-responsive element modulator
member entity reference: cAMP response element-binding protein
member entity reference: CREB1 isoform 2
member entity reference: Cyclic AMP-responsive element-binding protein 1 isoform B
member entity reference: Uncharacterized protein
member entity reference: Cyclic AMP-responsive element-binding protein 1
member entity reference: cAMP responsive element binding protein 1
member entity reference: cAMP-responsive element-binding protein 1b
member entity reference: cAMP-responsive element-binding protein 1

Uncharacterized protein
type: ProteinReference
xref: uniprot F6RIM7 300
xref: PTHR10218:SF230
organism: Monodelphis domestica

ncbitaxon 214684 177
type: UnificationXref
id: 214684
db: ncbitaxon

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: uniprot P21137 258
xref: PTHR24353:SF117
organism: Caenorhabditis elegans

G protein subunit beta 4
type: ProteinReference
xref: uniprot E2R2S8 58
organism: Canis lupus familiaris

Complex (GDP/G-Protein (s)/ GPCR (s))
type: Complex
component stoichiometry: GPCR s s12 sa5 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein s s11 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: GDP s8 sa3 STOICHIOMETRY ID COMPLEX
component: GDP
component: GPCR (s)
component: G-Protein (s)
feature: COMPLEX BINDING FEATURE s24 a35 371
feature: COMPLEX BINDING FEATURE s24 a35 367
feature: COMPLEX BINDING FEATURE s24 a35 369
cellular location: cytosol

uniprot F6TFY2 79
type: UnificationXref
id: F6TFY2
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2R2S3 56
organism: Canis lupus familiaris

By Homology
type: RelationshipTypeVocabulary

GDP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PENK isoform 3
type: ProteinReference
xref: uniprot H2QW70 216
xref: PTHR11438:SF3
organism: Pan troglodytes

uniprot H2PZK9 308
type: UnificationXref
id: H2PZK9
db: uniprot

uniprot P49177 136
type: UnificationXref
id: P49177
db: uniprot

ncbitaxon 284812 166
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q7Q6E0 329
type: UnificationXref
id: Q7Q6E0
db: uniprot

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 24

00696
type: UnificationXref
id: MOD:00696
db: mod

uniprot H2QMN4 309
type: UnificationXref
id: H2QMN4
db: uniprot

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
type: ProteinReference
xref: PTHR24353:SF135
xref: uniprot Q6DBV8 272
organism: Danio rerio

uniprot P12369 253
type: UnificationXref
id: P12369
db: uniprot

Protein kinase, cAMP-dependent, catalytic, beta a
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q7T374 277
organism: Danio rerio

uniprot F1N5B6 7
type: UnificationXref
id: F1N5B6
db: uniprot

uniprot F7H6T2 238
type: UnificationXref
id: F7H6T2
db: uniprot

uniprot P62871 146
type: UnificationXref
id: P62871
db: uniprot

uniprot P22694 260
type: UnificationXref
id: P22694
db: uniprot

uniprot P42866 15
type: UnificationXref
id: P42866
db: uniprot

cAMP response element-binding protein
type: ProteinReference
xref: uniprot Q7SX83 36
xref: PTHR45879:SF1
organism: Gallus gallus

uniprot Q8CGK7 201
type: UnificationXref
id: Q8CGK7
db: uniprot

G protein subunit alpha i2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot H2QMN4 309
organism: Pan troglodytes

G-Protein (s)
type: Protein
entity reference: G-Protein (s)
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa4 370
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Protein kinase cAMP-dependent type II regulatory subunit alpha
type: ProteinReference
xref: uniprot E2RRD1 229
xref: PTHR11635:SF153
organism: Canis lupus familiaris

Proenkephalin-A
type: DnaReference
xref: PTHR11438:SF3
organism: Macaca mulatta

AGAP006521-PA
type: ProteinReference
xref: uniprot Q7Q5C3 195
organism: Anopheles gambiae

uniprot A1L271 42
type: UnificationXref
id: A1L271
db: uniprot

uniprot Q6DGZ5 184
type: UnificationXref
id: Q6DGZ5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HEV7 286
xref: PTHR24229:SF2
organism: Macaca mulatta

DISSOCIATION
type: RelationshipTypeVocabulary

Complex (GDP/G-Protein (i)/ GPCR (i))
type: Complex
component stoichiometry: GDP s13 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein i s15 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: GPCR i s16 sa8 STOICHIOMETRY ID COMPLEX
component: GDP
component: G-Protein (i)
component: GPCR (i)
feature: COMPLEX BINDING FEATURE s26 a44 353
feature: COMPLEX BINDING FEATURE s26 a44 355
feature: COMPLEX BINDING FEATURE s26 a44 357
cellular location: cytosol

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot Q9DC51 334
xref: PTHR10218:SF230
organism: Mus musculus

STATE_TRANSITION_LEFT__CREB-RIGHT__CREB-_re4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 390
participant stoichiometry: PARTICIPANT STOICHIOMETRY re4 391
left: CREB
interaction type: STATE_TRANSITION
right: CREB

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot A8XW88 226
organism: Caenorhabditis briggsae

PARTICIPANT STOICHIOMETRY re12 397
type: Stoichiometry
physical entity: preproenkephalin mRNA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re12 396
type: Stoichiometry
physical entity: Complex (CREB/Protoenkephalin)
stoichiometric coefficient: 1.0

uniprot Q3SZ98 172
type: UnificationXref
id: Q3SZ98
db: uniprot

GPCR (s)
type: ProteinReference
xref: P05975
standard name: Gs protein coupled receptor
comment: ENTITY_REFERENCE_ID_DESC=Enkephalin release.PROTEIN.RECEPTOR.GPCR (s)
comment: ENTITY_REFERENCE_NOTES= Long Name: GPCR (s) Synonym: Long Name: GPCR (s) Accession: P05975
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Mu-type opioid receptor
member entity reference: Opioid receptor mu 1
member entity reference: Opioid receptor, mu 1

uniprot A4IFL6 43
type: UnificationXref
id: A4IFL6
db: uniprot

uniprot H2QFK0 240
type: UnificationXref
id: H2QFK0
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50150 138
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot P50151 139
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re1
controller: AC

uniprot O35417 217
type: UnificationXref
id: O35417
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot P50154 141
organism: Bos taurus

uniprot B8JHS2 3
type: UnificationXref
id: B8JHS2
db: uniprot

ncbitaxon 9913 8
type: UnificationXref
id: 9913
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
type: ProteinReference
xref: uniprot P50153 140
organism: Mus musculus

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7FSE3 306
organism: Ornithorhynchus anatinus

uniprot F2Z3T8 71
type: UnificationXref
id: F2Z3T8
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P50146 320
organism: Gallus gallus

uniprot F6ZAV4 340
type: UnificationXref
id: F6ZAV4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1M3D6 40
organism: Bos taurus

uniprot P16220 29
type: UnificationXref
id: P16220
db: uniprot

uniprot Q6TNT8 328
type: UnificationXref
id: Q6TNT8
db: uniprot

uniprot P43425 135
type: UnificationXref
id: P43425
db: uniprot

G protein alpha subunit Gi isoform X2
type: ProteinReference
xref: uniprot Q8WSS1 332
xref: PTHR10218:SF310
organism: Ciona intestinalis

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P27791 261
organism: Rattus norvegicus

ncbitaxon 8364 22
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot Q803H5 199
type: UnificationXref
id: Q803H5
db: uniprot

Cyclic AMP-responsive element-binding protein 1
type: ProteinReference
xref: PTHR45879:SF1
xref: uniprot P15337 28
organism: Rattus norvegicus

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot H2PYH8 287
type: UnificationXref
id: H2PYH8
db: uniprot

uniprot Q8MJ44 278
type: UnificationXref
id: Q8MJ44
db: uniprot

PTHR10218:SF302
type: RelationshipXref
id: PTHR10218:SF302
db: PANTHER Family
relationship type: By Homology

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot K7ADQ0 342
organism: Pan troglodytes

ncbitaxon 10090 16
type: UnificationXref
id: 10090
db: ncbitaxon

cAMP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V6P8 105
organism: Rattus norvegicus

uniprot P52287 142
type: UnificationXref
id: P52287
db: uniprot

PARTICIPANT STOICHIOMETRY re7 378
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re7 379
type: Stoichiometry
physical entity: PKA
stoichiometric coefficient: 1.0

uniprot W4YRI6 281
type: UnificationXref
id: W4YRI6
db: uniprot

uniprot Q7PXF7 275
type: UnificationXref
id: Q7PXF7
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot H2Q9G5 110
organism: Pan troglodytes

Proenkephalin-B
type: DnaReference
xref: PTHR11438:SF4
organism: Mus musculus

uniprot Q6P025 186
type: UnificationXref
id: Q6P025
db: uniprot

uniprot P51828 344
type: UnificationXref
id: P51828
db: uniprot

uniprot P08752 312
type: UnificationXref
id: P08752
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF320
xref: uniprot F6PV18 76
organism: Macaca mulatta

Proenkephalin
type: DnaReference
xref: PTHR11438:SF3
organism: Xenopus tropicalis

ncbitaxon 9544 24
type: UnificationXref
id: 9544
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63219 162
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63218 161
organism: Homo sapiens

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q503 233
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot P63217 160
organism: Bos taurus

uniprot H2QNS5 111
type: UnificationXref
id: H2QNS5
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63216 159
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63215 158
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
type: ProteinReference
xref: uniprot P63214 157
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P63213 156
organism: Mus musculus

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 227

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q15KE4 167
organism: Danio rerio

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 123

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BS74 53
organism: Gallus gallus

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot P29829 130
organism: Drosophila melanogaster

uniprot P05132 250
type: UnificationXref
id: P05132
db: uniprot

G protein subunit alpha i1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot A0A2I3S4R3 291
organism: Pan troglodytes

uniprot P50153 140
type: UnificationXref
id: P50153
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7F580 99
organism: Macaca mulatta

G protein subunit alpha o1
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot A0A2I3TFM8 292
organism: Pan troglodytes

Cyclic AMP-responsive element-binding protein 1
type: ProteinReference
xref: PTHR45879:SF1
xref: uniprot Q01147 31
organism: Mus musculus

ncbitaxon 13616 10
type: UnificationXref
id: 13616
db: ncbitaxon

GPCR i s16 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPCR (i)
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
type: ProteinReference
xref: uniprot Q9CXP8 203
organism: Mus musculus

Opioid receptor delta 1
type: ProteinReference
xref: uniprot E2QZY2 285
xref: PTHR24229:SF2
organism: Canis lupus familiaris

uniprot P62881 152
type: UnificationXref
id: P62881
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P04897 310
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: uniprot P59215 322
xref: PTHR10218:SF302
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RGI5 60
organism: Canis lupus familiaris

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P04899 311
organism: Homo sapiens

uniprot F7GI54 103
type: UnificationXref
id: F7GI54
db: uniprot

Enkephalin
type: Protein
entity reference: Enkephalin
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P51875 321
organism: Caenorhabditis elegans

G protein alpha o subunit
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P16378 316
organism: Drosophila melanogaster

uniprot P08753 313
type: UnificationXref
id: P08753
db: uniprot

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: PTHR11635:SF162
xref: uniprot W4YRI6 281
organism: Strongylocentrotus purpuratus

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 47

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 177

PARTICIPANT STOICHIOMETRY re1 394
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re1 395
type: Stoichiometry
physical entity: cAMP
stoichiometric coefficient: 1.0

uniprot O14775 118
type: UnificationXref
id: O14775
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P17343 122
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P18872 317
organism: Mus musculus

uniprot F7GQC5 307
type: UnificationXref
id: F7GQC5
db: uniprot

PTHR24353:SF133
type: RelationshipXref
id: PTHR24353:SF133
db: PANTHER Family
relationship type: By Homology

uniprot Q9CXP8 203
type: UnificationXref
id: Q9CXP8
db: uniprot

PTHR24353:SF137
type: RelationshipXref
id: PTHR24353:SF137
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF135
type: RelationshipXref
id: PTHR24353:SF135
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3SZ98 172
organism: Bos taurus

ncbitaxon 7719 333
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot F7CB49 91
type: UnificationXref
id: F7CB49
db: uniprot

ncbitaxon 7668 282
type: UnificationXref
id: 7668
db: ncbitaxon

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 51

uniprot F7E427 95
type: UnificationXref
id: F7E427
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6SSS3 78
organism: Monodelphis domestica

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q1D9 108
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6W548 82
organism: Macaca mulatta

uniprot Q27687 269
type: UnificationXref
id: Q27687
db: uniprot

uniprot Q6P967 327
type: UnificationXref
id: Q6P967
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 5

GNAI2 protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot A7MBH9 294
organism: Bos taurus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P52287 142
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION_LEFT__CREB-_preproenkephalin-RIGHT__Complex__CREB_Protoenkephalin_-_re11
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 375
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 373
participant stoichiometry: PARTICIPANT STOICHIOMETRY re11 374
left: preproenkephalin
left: CREB
interaction type: HETERODIMER_ASSOCIATION
right: Complex (CREB/Protoenkephalin)

uniprot A0NEH6 293
type: UnificationXref
id: A0NEH6
db: uniprot

G-Protein (s)
type: Protein
entity reference: G-Protein (s)
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa2 362
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P36408 132
type: UnificationXref
id: P36408
db: uniprot

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P00515 247
xref: PTHR11635:SF153
organism: Bos taurus

PTHR24353:SF128
type: RelationshipXref
id: PTHR24353:SF128
db: PANTHER Family
relationship type: By Homology

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P00517 248
organism: Bos taurus

uniprot Q922R0 279
type: UnificationXref
id: Q922R0
db: uniprot

PARTICIPANT STOICHIOMETRY re5 387
type: Stoichiometry
physical entity: Complex (GTP/G-Protein (i))
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 388
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 385
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re5 386
type: Stoichiometry
physical entity: Complex (GDP/G-Protein (i)/ GPCR (i))
stoichiometric coefficient: 1.0

uniprot H2R2Y2 27
type: UnificationXref
id: H2R2Y2
db: uniprot

PARTICIPANT STOICHIOMETRY re5 389
type: Stoichiometry
physical entity: GPCR (i)
stoichiometric coefficient: 1.0

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 10

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7AE17 115
organism: Pan troglodytes

uniprot Q9GNR4 280
type: UnificationXref
id: Q9GNR4
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E1BW98 54
organism: Gallus gallus

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 333

PTHR24353:SF117
type: RelationshipXref
id: PTHR24353:SF117
db: PANTHER Family
relationship type: By Homology

PTHR24353:SF116
type: RelationshipXref
id: PTHR24353:SF116
db: PANTHER Family
relationship type: By Homology

Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot A3KMS9 225
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot H2RI77 244
xref: PTHR24353:SF128
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G3J2 101
organism: Monodelphis domestica

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot B2RSH2 296
organism: Mus musculus

Adenylate cyclase
type: ProteinReference
xref: uniprot A0A1D5RHE7 336
xref: PTHR45627:SF6
organism: Macaca mulatta

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P08752 312
organism: Mus musculus

Proenkephalin-A
type: ProteinReference
xref: uniprot P01210 218
xref: PTHR11438:SF3
organism: Homo sapiens

Proenkephalin-A
type: ProteinReference
xref: uniprot P01211 219
xref: PTHR11438:SF3
organism: Bos taurus

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: PTHR10218:SF230
xref: uniprot P08754 314
organism: Homo sapiens

AGAP004940-PA
type: ProteinReference
xref: uniprot Q7PPI8 274
xref: PTHR11635:SF162
organism: Anopheles gambiae

Guanine nucleotide-binding protein G(K) subunit alpha
type: ProteinReference
xref: uniprot F6VL43 302
xref: PTHR10218:SF230
organism: Macaca mulatta

Guanine nucleotide-binding protein G(k) subunit alpha
type: ProteinReference
xref: uniprot P08753 313
xref: PTHR10218:SF230
organism: Rattus norvegicus

Proenkephalin-B
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot P01213 220
organism: Homo sapiens

CREB
type: Protein
entity reference: PKA
feature: PKA s5 a6 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DF43 183
organism: Xenopus tropicalis

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot P05132 250
organism: Mus musculus

uniprot H2Q3W7 109
type: UnificationXref
id: H2Q3W7
db: uniprot

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P05131 249
organism: Bos taurus

uniprot P22612 259
type: UnificationXref
id: P22612
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot Q9HAV0 205
organism: Homo sapiens

uniprot P51875 321
type: UnificationXref
id: P51875
db: uniprot

uniprot Q7Q6D4 198
type: UnificationXref
id: Q7Q6D4
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot Q10282 165
organism: Schizosaccharomyces pombe

Guanine nucleotide-binding protein G(olf) subunit alpha
type: ProteinReference
xref: uniprot P38405 134
organism: Homo sapiens

ACTIVE 283
type: EntityFeature
comment: Active state

PDYN isoform 1
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot A0A2J8MS47 210
organism: Pan troglodytes

Guanine nucleotide-binding protein G(i) subunit alpha-2
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot P38400 319
organism: Canis lupus familiaris

uniprot P63077 153
type: UnificationXref
id: P63077
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E2RJB3 62
organism: Canis lupus familiaris

uniprot Q3KRE3 171
type: UnificationXref
id: Q3KRE3
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 137

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P18851 124
organism: Saccharomyces cerevisiae

Guanine nucleotide-binding protein subunit beta-5b
type: ProteinReference
xref: uniprot Q6PBY0 188
organism: Danio rerio

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot E2RRA1 228
xref: PTHR11635:SF156
organism: Canis lupus familiaris

PKA s5 a6 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.21

uniprot F1LQT1 337
type: UnificationXref
id: F1LQT1
db: uniprot

Gbeta5
type: ProteinReference
xref: uniprot Q9W3J1 208
organism: Drosophila melanogaster

G protein subunit gamma 5
type: ProteinReference
xref: uniprot H2PZA6 107
organism: Pan troglodytes

ATP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1PJE5 69
organism: Canis lupus familiaris

uniprot P38400 319
type: UnificationXref
id: P38400
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot Q9UK08 207
organism: Homo sapiens

uniprot Q80TL1 348
type: UnificationXref
id: Q80TL1
db: uniprot

uniprot F1PJE5 69
type: UnificationXref
id: F1PJE5
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__CREB-RIGHT__CREB-_re4
controller: PKA

uniprot P04094 221
type: UnificationXref
id: P04094
db: uniprot

uniprot P20353 318
type: UnificationXref
id: P20353
db: uniprot

uniprot Q95104 224
type: UnificationXref
id: Q95104
db: uniprot

uniprot P17343 122
type: UnificationXref
id: P17343
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 4

cAMP-dependent protein kinase catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot Q8MJ44 278
organism: Canis lupus familiaris

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P13861 255
xref: PTHR11635:SF153
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot E9GNI4 232
organism: Daphnia pulex

uniprot F6V001 339
type: UnificationXref
id: F6V001
db: uniprot

uniprot Q29450 347
type: UnificationXref
id: Q29450
db: uniprot

G protein subunit beta 2
type: ProteinReference
xref: uniprot A0A2I3TUD1 39
organism: Pan troglodytes

uniprot F6Q9S4 234
type: UnificationXref
id: F6Q9S4
db: uniprot

ncbitaxon 10116 12
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot P50146 320
type: UnificationXref
id: P50146
db: uniprot

uniprot P81900 268
type: UnificationXref
id: P81900
db: uniprot

CREB
type: Protein
entity reference: CREB
feature: CREB s30 a9 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot F1A421 65
type: UnificationXref
id: F1A421
db: uniprot

uniprot F1NLV4 68
type: UnificationXref
id: F1NLV4
db: uniprot

GPCR (i)
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide, olfactory type
type: ProteinReference
xref: uniprot F1RE11 70
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6YZA3 86
organism: Monodelphis domestica

ncbitaxon 9258 75
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot A0A2J8MS47 210
type: UnificationXref
id: A0A2J8MS47
db: uniprot

Proenkephalin
type: ProteinReference
xref: uniprot F6Y5F6 214
xref: PTHR11438:SF3
organism: Xenopus tropicalis

GDP s8 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

uniprot P13861 255
type: UnificationXref
id: P13861
db: uniprot

uniprot F6UJE8 301
type: UnificationXref
id: F6UJE8
db: uniprot

uniprot F7BB02 90
type: UnificationXref
id: F7BB02
db: uniprot

uniprot Q5BH99 173
type: UnificationXref
id: Q5BH99
db: uniprot

uniprot F7FSE3 306
type: UnificationXref
id: F7FSE3
db: uniprot

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: uniprot P63097 324
xref: PTHR10218:SF227
organism: Bos taurus

Guanine nucleotide-binding protein G(i) subunit alpha-1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot P63096 323
organism: Homo sapiens

ncbitaxon 6945 49
type: UnificationXref
id: 6945
db: ncbitaxon

GDP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s13 sa6 354
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot F7FXA9 100
type: UnificationXref
id: F7FXA9
db: uniprot

Guanine nucleotide binding protein (G protein), beta polypeptide 3, like
type: ProteinReference
xref: uniprot Q6DH55 185
organism: Danio rerio

uniprot P00517 248
type: UnificationXref
id: P00517
db: uniprot

uniprot P63217 160
type: UnificationXref
id: P63217
db: uniprot

uniprot P12367 251
type: UnificationXref
id: P12367
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6TFY2 79
organism: Macaca mulatta

uniprot Q6NW93 273
type: UnificationXref
id: Q6NW93
db: uniprot

ncbitaxon 9598 18
type: UnificationXref
id: 9598
db: ncbitaxon

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 12

uniprot K7E376 116
type: UnificationXref
id: K7E376
db: uniprot

uniprot Q10282 165
type: UnificationXref
id: Q10282
db: uniprot

uniprot X1WDQ5 335
type: UnificationXref
id: X1WDQ5
db: uniprot

uniprot H2QW70 216
type: UnificationXref
id: H2QW70
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 64

uniprot E2RRA1 228
type: UnificationXref
id: E2RRA1
db: uniprot

INHIBITION
type: RelationshipTypeVocabulary

uniprot Q7Q6D2 196
type: UnificationXref
id: Q7Q6D2
db: uniprot

uniprot O14610 117
type: UnificationXref
id: O14610
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63078 154
organism: Mus musculus

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
type: ProteinReference
xref: uniprot P63077 153
organism: Rattus norvegicus

uniprot E2R2S8 58
type: UnificationXref
id: E2R2S8
db: uniprot

uniprot P68181 266
type: UnificationXref
id: P68181
db: uniprot

Guanine nucleotide-binding protein G(o) subunit alpha
type: ProteinReference
xref: PTHR10218:SF302
xref: uniprot P09471 315
organism: Homo sapiens

G-Protein (s)
type: ProteinReference
xref: P05977
standard name: Gs-protein
comment: ENTITY_REFERENCE_NOTES= Long Name: G-Protein (s) Synonym: Synonym not specified Accession: P05977
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Enkephalin release.PROTEIN.GENERIC.G-Protein (s)
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: G-protein beta subunit
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Uncharacterized protein
member entity reference: G protein alpha s subunit
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: GNB4 protein
member entity reference: AGAP005911-PA
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(f) subunit alpha
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
member entity reference: Guanine nucleotide-binding protein subunit beta-5a
member entity reference: Guanine nucleotide-binding protein subunit beta-5b
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5
member entity reference: G protein, Subunit Alpha
member entity reference: AGAP006521-PA
member entity reference: AGAP005913-PA
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: G protein subunit beta 2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
member entity reference: Guanine nucleotide-binding protein subunit beta-4
member entity reference: THO complex subunit, putative
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

uniprot Q7Q3T7 276
type: UnificationXref
id: Q7Q3T7
db: uniprot

Mu-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF7
xref: uniprot P33535 11
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P54313 144
organism: Rattus norvegicus

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot P54311 143
organism: Rattus norvegicus

cAMP responsive element binding protein 1
type: ProteinReference
xref: uniprot Q0V7N6 34
xref: PTHR45879:SF1
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot F7E427 95
organism: Ornithorhynchus anatinus

Proenkephalin-B
type: ProteinReference
xref: uniprot Q95104 224
xref: PTHR11438:SF4
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re7
controller: cAMP

PKA
type: ProteinReference
xref: P05972
standard name: Protein kinase A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Enkephalin release.PROTEIN.GENERIC.PKA
comment: ENTITY_REFERENCE_NOTES=Long Name: cAMP response element binding protein Synonym: Long Name: CREB Accession: P05971
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha
member entity reference: cAMP-dependent protein kinase type II-alpha regulatory subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit 1
member entity reference: Uncharacterized protein
member entity reference: cAMP-dependent protein kinase catalytic subunit gamma
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit beta
member entity reference: AGAP004940-PA
member entity reference: cAMP-dependent protein kinase catalytic subunit PRKX
member entity reference: cAMP-dependent protein kinase catalytic subunit
member entity reference: PRKACB isoform 3
member entity reference: cAMP-dependent protein kinase catalytic subunit beta isoform 1
member entity reference: cAMP-dependent protein kinase catalytic subunit beta
member entity reference: Protein kinase cAMP-activated catalytic subunit beta
member entity reference: cAMP-dependent protein kinase type II regulatory subunit
member entity reference: PRKACG isoform 1
member entity reference: Protein kinase, X-linked
member entity reference: cAMP-dependent protein kinase type II-beta regulatory subunit
member entity reference: AGAP008039-PA (Fragment)
member entity reference: Protein kinase cAMP-activated catalytic subunit alpha
member entity reference: Protein kinase A catalytic subunit isoform 2
member entity reference: Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta a
member entity reference: cAMP-dependent protein kinase catalytic subunit 3
member entity reference: Protein kinase A catalytic subunit
member entity reference: cAMP-dependent protein kinase catalytic subunit alpha isoform 1
member entity reference: Protein kinase A catalytic subunit isoform 1
member entity reference: Protein kinase, cAMP-dependent, catalytic, beta
member entity reference: AGAP001384-PA
member entity reference: Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
member entity reference: PRKAR2A isoform 1
member entity reference: Protein kinase cAMP-dependent type II regulatory subunit alpha

Adenylate cyclase
type: ProteinReference
xref: uniprot F6V001 339
xref: PTHR45627:SF6
organism: Monodelphis domestica

uniprot Q90Z40 202
type: UnificationXref
id: Q90Z40
db: uniprot

ncbitaxon 9615 57
type: UnificationXref
id: 9615
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot Q6PH57 189
organism: Danio rerio

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot Q7T3D3 330
organism: Danio rerio

Adenylate cyclase
type: ProteinReference
xref: uniprot F1MJV4 338
xref: PTHR45627:SF6
organism: Bos taurus

uniprot Q28024 169
type: UnificationXref
id: Q28024
db: uniprot

G06045
type: UnificationXref
id: G06045
db: PANTHER Pathway Component

uniprot P51817 265
type: UnificationXref
id: P51817
db: uniprot

STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re1
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 395
participant stoichiometry: PARTICIPANT STOICHIOMETRY re1 394
left: ATP
interaction type: STATE_TRANSITION
right: cAMP

uniprot P62879 150
type: UnificationXref
id: P62879
db: uniprot

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 66

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re2
controller: Complex (GTP/G-Protein)

preproenkephalin
type: DnaRegion
entity reference: preproenkephalin
feature: COMPLEX PARTICIPANT BINDING FEATURE s44 sa12 366
cellular location: cytosol
comment: SPECIES_TYPE=GENE

uniprot Q6PBR4 187
type: UnificationXref
id: Q6PBR4
db: uniprot

uniprot P21137 258
type: UnificationXref
id: P21137
db: uniprot

uniprot P33535 11
type: UnificationXref
id: P33535
db: uniprot

uniprot Q9HAV0 205
type: UnificationXref
id: Q9HAV0
db: uniprot

STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re2
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 392
participant stoichiometry: PARTICIPANT STOICHIOMETRY re2 393
left: AC
interaction type: STATE_TRANSITION
right: AC

PTHR11438:SF3
type: RelationshipXref
id: PTHR11438:SF3
db: PANTHER Family
relationship type: By Homology

ncbitaxon 559292 125
type: UnificationXref
id: 559292
db: ncbitaxon

PTHR11438:SF4
type: RelationshipXref
id: PTHR11438:SF4
db: PANTHER Family
relationship type: By Homology

uniprot F7DL70 341
type: UnificationXref
id: F7DL70
db: uniprot

cAMP-dependent protein kinase catalytic subunit
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot P34099 264
organism: Dictyostelium discoideum

AGAP005773-PA
type: ProteinReference
xref: uniprot A0NEH6 293
xref: PTHR10218:SF302
organism: Anopheles gambiae

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

cAMP-dependent protein kinase catalytic subunit 3
type: ProteinReference
xref: uniprot P16912 256
xref: PTHR24353:SF37
organism: Drosophila melanogaster

Guanine nucleotide-binding protein (G protein), beta 5
type: ProteinReference
xref: uniprot F7EBE7 96
organism: Xenopus tropicalis

uniprot F6Y3N2 85
type: UnificationXref
id: F6Y3N2
db: uniprot

uniprot F6V461 80
type: UnificationXref
id: F6V461
db: uniprot

AC
type: Protein
entity reference: AC
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
type: ProteinReference
xref: uniprot P59768 145
organism: Homo sapiens

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot P16520 121
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6V461 80
organism: Ornithorhynchus anatinus

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 174

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6PBR4 187
organism: Danio rerio

uniprot Q05337 163
type: UnificationXref
id: Q05337
db: uniprot

uniprot Q5KI86 176
type: UnificationXref
id: Q5KI86
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6DGZ5 184
organism: Danio rerio

Protein kinase, cAMP-dependent, catalytic, beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot Q3ZB92 270
organism: Danio rerio

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot J9P702 114
organism: Canis lupus familiaris

uniprot F6Q503 233
type: UnificationXref
id: F6Q503
db: uniprot

Protein kinase A catalytic subunit isoform 1
type: ProteinReference
xref: PTHR24353:SF67
xref: uniprot Q9GNR4 280
organism: Leishmania major

uniprot F6Z7F5 25
type: UnificationXref
id: F6Z7F5
db: uniprot

uniprot Q5BK52 271
type: UnificationXref
id: Q5BK52
db: uniprot

Complex (CREB/Protoenkephalin)
type: Complex
component stoichiometry: preproenkephalin s44 sa12 STOICHIOMETRY ID COMPLEX
component stoichiometry: CREB s20 sa11 STOICHIOMETRY ID COMPLEX
component: CREB
component: preproenkephalin
feature: COMPLEX BINDING FEATURE s35 a54 365
feature: COMPLEX BINDING FEATURE s35 a54 363
cellular location: cytosol

uniprot F1MYW8 67
type: UnificationXref
id: F1MYW8
db: uniprot

ncbitaxon 227321 174
type: UnificationXref
id: 227321
db: ncbitaxon

uniprot P26308 128
type: UnificationXref
id: P26308
db: uniprot

CREB
type: Protein
entity reference: CREB
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa11 364
feature: CREB s20 sa11 rs1
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Gi alpha subunit
type: ProteinReference
xref: uniprot C3XY80 297
xref: PTHR10218:SF310
organism: Branchiostoma floridae

ncbitaxon 5786 66
type: UnificationXref
id: 5786
db: ncbitaxon

PDYN isoform 1
type: DnaReference
xref: PTHR11438:SF4
organism: Pan troglodytes

preproenkephalin mRNA
type: RnaRegion
entity reference: preproenkephalin mRNA
cellular location: cytosol
comment: SPECIES_TYPE=RNA

uniprot E2R9G5 59
type: UnificationXref
id: E2R9G5
db: uniprot

cAMP-responsive element modulator
type: ProteinReference
xref: uniprot Q03061 33
organism: Rattus norvegicus

uniprot F6QA46 21
type: UnificationXref
id: F6QA46
db: uniprot

uniprot H2QZN8 112
type: UnificationXref
id: H2QZN8
db: uniprot

P05978
type: UnificationXref
id: P05978
db: PANTHER Pathway Component

P05977
type: UnificationXref
id: P05977
db: PANTHER Pathway Component

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
type: ProteinReference
xref: uniprot F7FXA9 100
organism: Macaca mulatta

uniprot F6W548 82
type: UnificationXref
id: F6W548
db: uniprot

uniprot F1RE11 70
type: UnificationXref
id: F1RE11
db: uniprot

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2b
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot X1WDQ5 335
organism: Danio rerio

uniprot P63218 161
type: UnificationXref
id: P63218
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot P29387 129
organism: Mus musculus

Opioid receptor, mu 1
type: ProteinReference
xref: uniprot B8JHS2 3
xref: PTHR24229:SF7
organism: Danio rerio

uniprot F7G7I9 102
type: UnificationXref
id: F7G7I9
db: uniprot

uniprot P01213 220
type: UnificationXref
id: P01213
db: uniprot

GDP s13 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2QZN8 112
organism: Pan troglodytes

Gnb2 protein
type: ProteinReference
xref: uniprot Q5BJ11 175
organism: Danio rerio

cAMP-responsive element modulator
type: ProteinReference
xref: uniprot Q03060 32
organism: Homo sapiens

uniprot Q9UK08 207
type: UnificationXref
id: Q9UK08
db: uniprot

ncbitaxon 44689 133
type: UnificationXref
id: 44689
db: ncbitaxon

PKA
type: Protein
entity reference: PKA
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P31324 263
type: UnificationXref
id: P31324
db: uniprot

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 125

uniprot F7EBE7 96
type: UnificationXref
id: F7EBE7
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 127

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
type: ProteinReference
xref: uniprot Q61011 180
organism: Mus musculus

uniprot Q61016 181
type: UnificationXref
id: Q61016
db: uniprot

P05975
type: UnificationXref
id: P05975
db: PANTHER Pathway Component

P05976
type: UnificationXref
id: P05976
db: PANTHER Pathway Component

uniprot P17612 257
type: UnificationXref
id: P17612
db: uniprot

GTP s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PTHR10218:SF212
type: RelationshipXref
id: PTHR10218:SF212
db: PANTHER Family
relationship type: By Homology

P05973
type: UnificationXref
id: P05973
db: PANTHER Pathway Component

P05974
type: UnificationXref
id: P05974
db: PANTHER Pathway Component

P05971
type: UnificationXref
id: P05971
db: PANTHER Pathway Component

P05972
type: UnificationXref
id: P05972
db: PANTHER Pathway Component

uniprot E1BW98 54
type: UnificationXref
id: E1BW98
db: uniprot

uniprot P01211 219
type: UnificationXref
id: P01211
db: uniprot

uniprot P33533 289
type: UnificationXref
id: P33533
db: uniprot

uniprot P09471 315
type: UnificationXref
id: P09471
db: uniprot

AGAP001506-PA
type: ProteinReference
xref: uniprot Q7PXP3 193
organism: Anopheles gambiae

PTHR24229:SF2
type: RelationshipXref
id: PTHR24229:SF2
db: PANTHER Family
relationship type: By Homology

GPCR (s)
type: Protein
entity reference: GPCR (s)
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa5 372
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P16520 121
type: UnificationXref
id: P16520
db: uniprot

CREB s30 a9 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.21

PTHR24229:SF7
type: RelationshipXref
id: PTHR24229:SF7
db: PANTHER Family
relationship type: By Homology

uniprot F1P977 299
type: UnificationXref
id: F1P977
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot Q61016 181
organism: Mus musculus

PTHR10218:SF227
type: RelationshipXref
id: PTHR10218:SF227
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot Q61017 182
organism: Mus musculus

uniprot Q8WSS1 332
type: UnificationXref
id: Q8WSS1
db: uniprot

preproenkephalin mRNA
type: RnaRegionReference
comment: ENTITY_REFERENCE_ID_DESC=Enkephalin release.RNA.RNA.preproenkephalin mRNA
comment: ENTITY_REFERENCE_NOTES=Long Name: preproenkephalin mRNA Synonym: Synonym not specified Accession: G06046

uniprot Q20636 168
type: UnificationXref
id: Q20636
db: uniprot

uniprot P20354 126
type: UnificationXref
id: P20354
db: uniprot

uniprot A3QJX7 284
type: UnificationXref
id: A3QJX7
db: uniprot

uniprot G3V8K2 106
type: UnificationXref
id: G3V8K2
db: uniprot

PTHR10218:SF230
type: RelationshipXref
id: PTHR10218:SF230
db: PANTHER Family
relationship type: By Homology

uniprot P30671 131
type: UnificationXref
id: P30671
db: uniprot

ncbitaxon 7227 127
type: UnificationXref
id: 7227
db: ncbitaxon

ncbitaxon 7739 51
type: UnificationXref
id: 7739
db: ncbitaxon

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 22

uniprot P11017 120
type: UnificationXref
id: P11017
db: uniprot

uniprot E1C795 55
type: UnificationXref
id: E1C795
db: uniprot

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF37
xref: uniprot Q922R0 279
organism: Mus musculus

uniprot P26769 343
type: UnificationXref
id: P26769
db: uniprot

uniprot Q0V7N6 34
type: UnificationXref
id: Q0V7N6
db: uniprot

Prodynorphin
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot F1R4H8 212
organism: Danio rerio

uniprot Q5IS39 17
type: UnificationXref
id: Q5IS39
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YPT4 23
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
type: ProteinReference
xref: uniprot O14610 117
organism: Homo sapiens

uniprot P62880 151
type: UnificationXref
id: P62880
db: uniprot

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P49177 136
organism: Arabidopsis thaliana

uniprot Q9W3J1 208
type: UnificationXref
id: Q9W3J1
db: uniprot

uniprot P63078 154
type: UnificationXref
id: P63078
db: uniprot

uniprot A5PKD6 45
type: UnificationXref
id: A5PKD6
db: uniprot

uniprot Q7PXP3 193
type: UnificationXref
id: Q7PXP3
db: uniprot

uniprot E2RHY4 61
type: UnificationXref
id: E2RHY4
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
type: ProteinReference
xref: uniprot P11017 120
organism: Bos taurus

Mu-type opioid receptor
type: ProteinReference
xref: uniprot F1N5B6 7
xref: PTHR24229:SF7
organism: Bos taurus

Proenkephalin-B
type: DnaReference
xref: PTHR11438:SF4
organism: Rattus norvegicus

PKA
type: Protein
entity reference: PKA
feature: ACTIVE 283
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P29387 129
type: UnificationXref
id: P29387
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T2 238
xref: PTHR24353:SF37
organism: Macaca mulatta

uniprot D3ZLD6 52
type: UnificationXref
id: D3ZLD6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H6T7 104
organism: Macaca mulatta

uniprot A0A2I3S4R3 291
type: UnificationXref
id: A0A2I3S4R3
db: uniprot

uniprot R4GKD1 209
type: UnificationXref
id: R4GKD1
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re2
control type: INHIBITION
controller: Complex (GTP/G-Protein (i))

uniprot F7ERP8 97
type: UnificationXref
id: F7ERP8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CB49 91
organism: Monodelphis domestica

CREB s20 sa11 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.21

Protein kinase, cAMP-dependent, regulatory, type II, alpha, B
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot Q6NW93 273
organism: Danio rerio

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
type: ProteinReference
xref: PTHR10218:SF320
xref: uniprot Q6R0H7 190
organism: Mus musculus

uniprot P68182 267
type: UnificationXref
id: P68182
db: uniprot

uniprot P27791 261
type: UnificationXref
id: P27791
db: uniprot

ncbitaxon 5664 231
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot Q01147 31
type: UnificationXref
id: Q01147
db: uniprot

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot F5HH30 72
organism: Neurospora crassa

Guanine nucleotide-binding protein G(O) subunit alpha isoform a
type: ProteinReference
xref: uniprot F7GQC5 307
xref: PTHR10218:SF302
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P43425 135
organism: Rattus norvegicus

Protein kinase, X-linked
type: ProteinReference
xref: uniprot Q5BK52 271
xref: PTHR24353:SF37
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot A4IGZ2 44
organism: Xenopus tropicalis

uniprot A7MBH9 294
type: UnificationXref
id: A7MBH9
db: uniprot

uniprot F7HAK5 239
type: UnificationXref
id: F7HAK5
db: uniprot

uniprot P16378 316
type: UnificationXref
id: P16378
db: uniprot

cAMP-responsive element modulator
type: ProteinReference
xref: uniprot P27699 30
organism: Mus musculus

preproenkephalin
type: DnaRegion
entity reference: preproenkephalin
cellular location: cytosol
comment: SPECIES_TYPE=GENE

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q28024 169
organism: Bos taurus

G-Protein (i)
type: ProteinReference
xref: P05974
standard name: Gi-protein
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Enkephalin release.PROTEIN.GENERIC.G-Protein (i)
comment: ENTITY_REFERENCE_NOTES= Long Name: G-Protein (i) Synonym: Synonym not specified Accession: P05974
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
member entity reference: G-protein beta subunit
member entity reference: Guanine nucleotide-binding protein subunit gamma
member entity reference: Guanine nucleotide-binding protein G(o) subunit alpha
member entity reference: Uncharacterized protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
member entity reference: G protein subunit alpha i1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
member entity reference: GNB4 protein
member entity reference: AGAP005911-PA
member entity reference: Guanine nucleotide-binding protein subunit beta-1
member entity reference: Gnai3 protein
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
member entity reference: Guanine nucleotide-binding protein subunit beta-2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
member entity reference: G protein subunit alpha i3
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 2
member entity reference: Guanine nucleotide-binding protein subunit beta-5a
member entity reference: Guanine nucleotide-binding protein subunit beta-5b
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
member entity reference: G protein alpha i subunit
member entity reference: G protein subunit beta 4
member entity reference: Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-1
member entity reference: Guanine nucleotide-binding protein G(i) subunit alpha-2
member entity reference: Guanine nucleotide-binding protein G(O) subunit alpha 1
member entity reference: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
member entity reference: Guanine nucleotide-binding protein (G protein), beta 5
member entity reference: AGAP005904-PA
member entity reference: G protein alpha subunit Gi isoform X2
member entity reference: Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
member entity reference: AGAP005913-PA
member entity reference: Guanine nucleotide-binding protein subunit beta
member entity reference: G protein subunit beta 2

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XWE8 84
organism: Monodelphis domestica

uniprot P15337 28
type: UnificationXref
id: P15337
db: uniprot

uniprot E9GNI4 232
type: UnificationXref
id: E9GNI4
db: uniprot

AGAP005904-PA
type: ProteinReference
xref: uniprot Q7Q6E0 329
xref: PTHR10218:SF310
organism: Anopheles gambiae

uniprot H2QXB9 241
type: UnificationXref
id: H2QXB9
db: uniprot

AGAP005911-PA
type: ProteinReference
xref: uniprot Q7Q6D4 198
organism: Anopheles gambiae

uniprot H2R1G3 242
type: UnificationXref
id: H2R1G3
db: uniprot

AGAP005913-PA
type: ProteinReference
xref: uniprot Q7Q6D2 196
organism: Anopheles gambiae

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F6UJE8 301
organism: Monodelphis domestica

AGAP005912-PA
type: ProteinReference
xref: uniprot Q7Q6D3 197
organism: Anopheles gambiae

cAMP-responsive element-binding protein 1b
type: ProteinReference
xref: uniprot A0A0R4IFU8 19
organism: Danio rerio

Bos taurus
type: BioSource
xref: ncbitaxon 9913 8

uniprot Q7KPV0 192
type: UnificationXref
id: Q7KPV0
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 75

uniprot A0A1D5RHE7 336
type: UnificationXref
id: A0A1D5RHE7
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot H2Q3W7 109
organism: Pan troglodytes

ncbitaxon 665079 47
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot P04897 310
type: UnificationXref
id: P04897
db: uniprot

uniprot Q03061 33
type: UnificationXref
id: Q03061
db: uniprot

uniprot H2Q1D9 108
type: UnificationXref
id: H2Q1D9
db: uniprot

uniprot K7AEL3 246
type: UnificationXref
id: K7AEL3
db: uniprot

uniprot A8XW88 226
type: UnificationXref
id: A8XW88
db: uniprot

uniprot H2RI77 244
type: UnificationXref
id: H2RI77
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q28H40 170
organism: Xenopus tropicalis

uniprot P62873 148
type: UnificationXref
id: P62873
db: uniprot

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot P30671 131
organism: Bos taurus

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot P31324 263
organism: Mus musculus

Proenkephalin-A
type: DnaReference
xref: PTHR11438:SF3
organism: Mus musculus

G protein alpha i subunit
type: ProteinReference
xref: uniprot P20353 318
xref: PTHR10218:SF310
organism: Drosophila melanogaster

G protein alpha s subunit
type: ProteinReference
xref: uniprot P20354 126
xref: PTHR10218:SF212
organism: Drosophila melanogaster

uniprot B2RSH2 296
type: UnificationXref
id: B2RSH2
db: uniprot

eco ECO:0000305 38
type: UnificationXref
id: ECO:0000305
db: eco

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 49

uniprot P59768 145
type: UnificationXref
id: P59768
db: uniprot

uniprot Q08462 346
type: UnificationXref
id: Q08462
db: uniprot

uniprot F6SSS3 78
type: UnificationXref
id: F6SSS3
db: uniprot

uniprot B7Q3T6 48
type: UnificationXref
id: B7Q3T6
db: uniprot

AGAP008039-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q3T7 276
xref: PTHR24353:SF117
organism: Anopheles gambiae

Prodynorphin
type: DnaReference
xref: PTHR11438:SF4
organism: Danio rerio

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot F1A421 65
organism: Dictyostelium purpureum

cAMP-dependent protein kinase catalytic subunit 1
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot P12370 254
organism: Drosophila melanogaster

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 57

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A3Q1NGS8 41
organism: Bos taurus

G protein subunit beta 4
type: ProteinReference
xref: uniprot H2QNS5 111
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7G7I9 102
organism: Ornithorhynchus anatinus

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot Q80TL1 348
xref: PTHR45627:SF6
organism: Mus musculus

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 360
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P16912 256
type: UnificationXref
id: P16912
db: uniprot

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P31323 262
xref: PTHR11635:SF156
organism: Homo sapiens

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7CFG8 92
organism: Monodelphis domestica

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 37

Beta-neoendorphin-dynorphin
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot F6R267 213
organism: Macaca mulatta

cAMP-dependent protein kinase type II-beta regulatory subunit
type: ProteinReference
xref: uniprot P12369 253
xref: PTHR11635:SF156
organism: Rattus norvegicus

Mu-type opioid receptor
type: ProteinReference
xref: uniprot Q5IS39 17
xref: PTHR24229:SF7
organism: Pan troglodytes

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: uniprot P12367 251
xref: PTHR11635:SF153
organism: Mus musculus

cAMP-dependent protein kinase type II-alpha regulatory subunit
type: ProteinReference
xref: PTHR11635:SF153
xref: uniprot P12368 252
organism: Rattus norvegicus

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot P51828 344
xref: PTHR45627:SF9
organism: Homo sapiens

uniprot P54311 143
type: UnificationXref
id: P54311
db: uniprot

uniprot Q3ZB92 270
type: UnificationXref
id: Q3ZB92
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7GI54 103
organism: Monodelphis domestica

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot P51829 345
xref: PTHR45627:SF9
organism: Mus musculus

Complex (GTP/G-Protein (i))
type: Complex
component stoichiometry: GTP s17 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: G Protein i s19 sa10 STOICHIOMETRY ID COMPLEX
component: G-Protein (i)
component: GTP
feature: ACTIVE 283
feature: COMPLEX BINDING FEATURE s28 a47 351
feature: COMPLEX BINDING FEATURE s28 a47 349
cellular location: cytosol

eco ECO:0000250 5
type: UnificationXref
id: ECO:0000250
db: eco

Gnb3 protein
type: ProteinReference
xref: uniprot Q6P025 186
organism: Danio rerio

uniprot P18872 317
type: UnificationXref
id: P18872
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5KI86 176
organism: Cryptococcus neoformans

Guanine nucleotide binding protein, beta subunit
type: ProteinReference
xref: uniprot E9FUX0 63
organism: Daphnia pulex

cAMP-dependent protein kinase catalytic subunit PRKX
type: ProteinReference
xref: PTHR24353:SF133
xref: uniprot P51817 265
organism: Homo sapiens

uniprot G7MZE3 215
type: UnificationXref
id: G7MZE3
db: uniprot

uniprot E2QZY2 285
type: UnificationXref
id: E2QZY2
db: uniprot

G protein, Subunit Alpha
type: ProteinReference
xref: uniprot Q7KPV0 192
organism: Caenorhabditis elegans

Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide O, b
type: ProteinReference
xref: PTHR10218:SF331
xref: uniprot Q6P967 327
organism: Danio rerio

GTP
type: SmallMolecule
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9UBI6 206
organism: Homo sapiens

Adenylate cyclase type 7
type: ProteinReference
xref: uniprot Q29450 347
xref: PTHR45627:SF9
organism: Bos taurus

ncbitaxon 3702 137
type: UnificationXref
id: 3702
db: ncbitaxon

cAMP-responsive element-binding protein 1
type: ProteinReference
xref: PTHR45879:SF1
xref: uniprot F6QA46 21
organism: Xenopus tropicalis

G Protein s s11 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein (s)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PVT7 77
organism: Monodelphis domestica

uniprot F6XWE8 84
type: UnificationXref
id: F6XWE8
db: uniprot

uniprot Q6PBY0 188
type: UnificationXref
id: Q6PBY0
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Y3N2 85
organism: Monodelphis domestica

THO complex subunit, putative
type: ProteinReference
xref: uniprot B7Q3T6 48
organism: Ixodes scapularis

cAMP-dependent protein kinase catalytic subunit gamma
type: ProteinReference
xref: uniprot P22612 259
xref: PTHR24353:SF137
organism: Homo sapiens

cAMP-dependent protein kinase type II regulatory subunit
type: ProteinReference
xref: uniprot P81900 268
xref: PTHR11635:SF162
organism: Drosophila melanogaster

Delta-type opioid receptor
type: ProteinReference
xref: uniprot P32300 288
xref: PTHR24229:SF2
organism: Mus musculus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6XHP0 83
organism: Macaca mulatta

STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 379
participant stoichiometry: PARTICIPANT STOICHIOMETRY re7 378
left: PKA
interaction type: STATE_TRANSITION
right: PKA

Pain relief Analgesia via binding to opioid receptor
type: Pathway

ncbitaxon 367110 73
type: UnificationXref
id: 367110
db: ncbitaxon

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
type: ProteinReference
xref: uniprot Q9DAS9 204
organism: Mus musculus

uniprot F6Y5F6 214
type: UnificationXref
id: F6Y5F6
db: uniprot

uniprot Q7Q6D3 197
type: UnificationXref
id: Q7Q6D3
db: uniprot

G Protein i s19 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein (i)
stoichiometric coefficient: 1.0

uniprot Q9UBI6 206
type: UnificationXref
id: Q9UBI6
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7ASR8 89
organism: Macaca mulatta

uniprot Q3ZCA7 325
type: UnificationXref
id: Q3ZCA7
db: uniprot

uniprot C3ZSF0 50
type: UnificationXref
id: C3ZSF0
db: uniprot

uniprot A8E7S2 211
type: UnificationXref
id: A8E7S2
db: uniprot

Guanine nucleotide-binding protein subunit beta-1
type: ProteinReference
xref: uniprot P26308 128
organism: Drosophila melanogaster

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: PTHR11635:SF156
xref: uniprot F6Q9S4 234
organism: Bos taurus

uniprot P22005 223
type: UnificationXref
id: P22005
db: uniprot

uniprot P41143 290
type: UnificationXref
id: P41143
db: uniprot

cAMP-responsive element modulator
type: ProteinReference
xref: uniprot Q1LZH5 35
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot F7CXD0 94
organism: Monodelphis domestica

G-protein beta subunit
type: ProteinReference
xref: uniprot Q5BH99 173
organism: Emericella nidulans

Protein kinase cAMP-activated catalytic subunit alpha
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H2QFK0 240
organism: Pan troglodytes

uniprot A4IGZ2 44
type: UnificationXref
id: A4IGZ2
db: uniprot

GPCR s s12 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GPCR (s)
stoichiometric coefficient: 1.0

uniprot F6VPY1 81
type: UnificationXref
id: F6VPY1
db: uniprot

Proenkephalin-A
type: DnaReference
xref: PTHR11438:SF3
organism: Bos taurus

uniprot F7EBQ5 236
type: UnificationXref
id: F7EBQ5
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 194

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F1MYW8 67
organism: Bos taurus

uniprot F7CFG8 92
type: UnificationXref
id: F7CFG8
db: uniprot

Protein kinase cAMP-dependent type II regulatory subunit beta
type: ProteinReference
xref: uniprot H2RER5 243
xref: PTHR11635:SF156
organism: Pan troglodytes

uniprot A0A2I3TFM8 292
type: UnificationXref
id: A0A2I3TFM8
db: uniprot

uniprot P59215 322
type: UnificationXref
id: P59215
db: uniprot

GTP s17 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot Q5I080 326
type: UnificationXref
id: Q5I080
db: uniprot

PARTICIPANT STOICHIOMETRY re4 391
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

Adenylate cyclase type 2
type: ProteinReference
xref: uniprot P26769 343
xref: PTHR45627:SF6
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY re4 390
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

PTHR24353:SF67
type: RelationshipXref
id: PTHR24353:SF67
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7BB02 90
organism: Macaca mulatta

uniprot F7ASR8 89
type: UnificationXref
id: F7ASR8
db: uniprot

Gnb1l protein
type: ProteinReference
xref: uniprot Q803H5 199
organism: Danio rerio

uniprot F6VL43 302
type: UnificationXref
id: F6VL43
db: uniprot

uniprot P34099 264
type: UnificationXref
id: P34099
db: uniprot

uniprot P35372 13
type: UnificationXref
id: P35372
db: uniprot

KNOWN_TRANSITION_OMITTED_LEFT__preproenkephalin_mRNA-RIGHT__Enkephalin-_re10
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 377
participant stoichiometry: PARTICIPANT STOICHIOMETRY re10 376
left: preproenkephalin mRNA
interaction type: KNOWN_TRANSITION_OMITTED
right: Enkephalin

uniprot C3XY80 297
type: UnificationXref
id: C3XY80
db: uniprot

uniprot Q7ZW82 331
type: UnificationXref
id: Q7ZW82
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q3KRE3 171
organism: Rattus norvegicus

uniprot F7FD32 305
type: UnificationXref
id: F7FD32
db: uniprot

G protein subunit beta 5
type: ProteinReference
xref: uniprot E2RHY4 61
organism: Canis lupus familiaris

preproenkephalin s44 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: preproenkephalin
stoichiometric coefficient: 1.0

uniprot P63214 157
type: UnificationXref
id: P63214
db: uniprot

ncbitaxon 7165 194
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot F7ES96 98
type: UnificationXref
id: F7ES96
db: uniprot

GPCR (i)
type: Protein
entity reference: GPCR (i)
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa8 358
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
type: ProteinReference
xref: uniprot O60262 119
organism: Homo sapiens

PTHR24353:SF82
type: RelationshipXref
id: PTHR24353:SF82
db: PANTHER Family
relationship type: By Homology

Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
type: ProteinReference
xref: uniprot Q3ZCA7 325
xref: PTHR10218:SF230
organism: Bos taurus

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Proenkephalin-B
type: DnaReference
xref: PTHR11438:SF4
organism: Bos taurus

PARTICIPANT STOICHIOMETRY re10 376
type: Stoichiometry
physical entity: preproenkephalin mRNA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re10 377
type: Stoichiometry
physical entity: Enkephalin
stoichiometric coefficient: 1.0

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot D3ZLD6 52
organism: Rattus norvegicus

DISSOCIATION_LEFT__GTP-_Complex__GDP_G_Protein__s___GPCR__s__-RIGHT__GPCR__s_-_GDP-_Complex__GTP_G_Protein_-_re6
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 383
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 384
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 382
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 380
participant stoichiometry: PARTICIPANT STOICHIOMETRY re6 381
left: Complex (GDP/G-Protein (s)/ GPCR (s))
left: GTP
interaction type: DISSOCIATION
right: GDP
right: GPCR (s)
right: Complex (GTP/G-Protein)

Proenkephalin-A
type: DnaReference
xref: PTHR11438:SF3
organism: Homo sapiens

PTHR24353:SF37
type: RelationshipXref
id: PTHR24353:SF37
db: PANTHER Family
relationship type: By Homology

uniprot F7A472 304
type: UnificationXref
id: F7A472
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 166

uniprot E1BS74 53
type: UnificationXref
id: E1BS74
db: uniprot

uniprot F6PGC8 74
type: UnificationXref
id: F6PGC8
db: uniprot

G Protein i s15 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein (i)
stoichiometric coefficient: 1.0

uniprot Q7T374 277
type: UnificationXref
id: Q7T374
db: uniprot

PTHR45879:SF1
type: RelationshipXref
id: PTHR45879:SF1
db: PANTHER Family
relationship type: By Homology

uniprot P51829 345
type: UnificationXref
id: P51829
db: uniprot

uniprot F6ZIZ9 88
type: UnificationXref
id: F6ZIZ9
db: uniprot

Proenkephalin-B
type: DnaReference
xref: PTHR11438:SF4
organism: Homo sapiens

uniprot P63219 162
type: UnificationXref
id: P63219
db: uniprot

uniprot P63213 156
type: UnificationXref
id: P63213
db: uniprot

Mu-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF7
xref: uniprot P42866 15
organism: Mus musculus

uniprot Q7T3D3 330
type: UnificationXref
id: Q7T3D3
db: uniprot

PTHR11635:SF162
type: RelationshipXref
id: PTHR11635:SF162
db: PANTHER Family
relationship type: By Homology

DISSOCIATION
type: InteractionVocabulary

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q0VFC4 164
organism: Xenopus tropicalis

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q6TH03 191
organism: Danio rerio

Guanine nucleotide-binding protein subunit beta-2
type: ProteinReference
xref: uniprot Q20636 168
organism: Caenorhabditis elegans

Beta-neoendorphin-dynorphin
type: DnaReference
xref: PTHR11438:SF4
organism: Macaca mulatta

Proenkephalin-A
type: ProteinReference
xref: uniprot P22005 223
xref: PTHR11438:SF3
organism: Mus musculus

uniprot G3V6P8 105
type: UnificationXref
id: G3V6P8
db: uniprot

uniprot O60262 119
type: UnificationXref
id: O60262
db: uniprot

GNB4 protein
type: ProteinReference
xref: uniprot A5PKD6 45
organism: Bos taurus

uniprot A0A3Q1M3D6 40
type: UnificationXref
id: A0A3Q1M3D6
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 14

uniprot Q9DC51 334
type: UnificationXref
id: Q9DC51
db: uniprot

uniprot P63216 159
type: UnificationXref
id: P63216
db: uniprot

uniprot J9P702 114
type: UnificationXref
id: J9P702
db: uniprot

uniprot P12368 252
type: UnificationXref
id: P12368
db: uniprot

PTHR11635:SF156
type: RelationshipXref
id: PTHR11635:SF156
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10218:SF73
xref: uniprot F7FD32 305
organism: Macaca mulatta

PTHR11635:SF153
type: RelationshipXref
id: PTHR11635:SF153
db: PANTHER Family
relationship type: By Homology

uniprot P08754 314
type: UnificationXref
id: P08754
db: uniprot

uniprot A0A3Q1NGS8 41
type: UnificationXref
id: A0A3Q1NGS8
db: uniprot

uniprot P50151 139
type: UnificationXref
id: P50151
db: uniprot

uniprot F7HEV7 286
type: UnificationXref
id: F7HEV7
db: uniprot

cAMP-dependent protein kinase catalytic subunit alpha isoform 1
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot H9EQQ4 245
organism: Macaca mulatta

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide a
type: ProteinReference
xref: uniprot Q7ZW82 331
xref: PTHR10218:SF227
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HAK5 239
xref: PTHR11635:SF153
organism: Macaca mulatta

uniprot F6ZDB2 87
type: UnificationXref
id: F6ZDB2
db: uniprot

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 282

cAMP-dependent protein kinase catalytic subunit beta
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot P22694 260
organism: Homo sapiens

uniprot H2R3A6 113
type: UnificationXref
id: H2R3A6
db: uniprot

GPCR (s)
type: Protein
cellular location: cytosol
comment: SPECIES_TYPE=PROTEIN

uniprot P12370 254
type: UnificationXref
id: P12370
db: uniprot

uniprot Q6DBV8 272
type: UnificationXref
id: Q6DBV8
db: uniprot

uniprot F6YPT4 23
type: UnificationXref
id: F6YPT4
db: uniprot

uniprot Q15KE4 167
type: UnificationXref
id: Q15KE4
db: uniprot

Proenkephalin-B
type: ProteinReference
xref: PTHR11438:SF4
xref: uniprot O35417 217
organism: Mus musculus

Proenkephalin-B
type: ProteinReference
xref: uniprot P06300 222
xref: PTHR11438:SF4
organism: Rattus norvegicus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot E1C795 55
organism: Gallus gallus

uniprot A0A2I3TUD1 39
type: UnificationXref
id: A0A2I3TUD1
db: uniprot

uniprot F6RIM7 300
type: UnificationXref
id: F6RIM7
db: uniprot

PRKAR2A isoform 1
type: ProteinReference
xref: uniprot K7AEL3 246
xref: PTHR11635:SF153
organism: Pan troglodytes

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot R4GKD1 209
organism: Gallus gallus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ES96 98
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NLV4 68
organism: Gallus gallus

uniprot Q6DH55 185
type: UnificationXref
id: Q6DH55
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot G3V8K2 106
organism: Rattus norvegicus

CREB1 isoform 2
type: ProteinReference
xref: uniprot H2R2Y2 27
xref: PTHR45879:SF1
organism: Pan troglodytes

uniprot P63212 155
type: UnificationXref
id: P63212
db: uniprot

uniprot F7CTP1 93
type: UnificationXref
id: F7CTP1
db: uniprot

AGAP001384-PA
type: ProteinReference
xref: PTHR24353:SF117
xref: uniprot Q7PXF7 275
organism: Anopheles gambiae

uniprot F6XHP0 83
type: UnificationXref
id: F6XHP0
db: uniprot

uniprot P04899 311
type: UnificationXref
id: P04899
db: uniprot

PTHR10218:SF73
type: RelationshipXref
id: PTHR10218:SF73
db: PANTHER Family
relationship type: By Homology

uniprot F1MJV4 338
type: UnificationXref
id: F1MJV4
db: uniprot

Guanine nucleotide-binding protein G(f) subunit alpha
type: ProteinReference
xref: uniprot Q05337 163
organism: Drosophila melanogaster

Guanine nucleotide-binding protein beta subunit
type: ProteinReference
xref: uniprot A7EDU2 46
organism: Sclerotinia sclerotiorum

uniprot F7F580 99
type: UnificationXref
id: F7F580
db: uniprot

ncbitaxon 6239 123
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot Q6DF43 183
type: UnificationXref
id: Q6DF43
db: uniprot

uniprot E9AFM1 230
type: UnificationXref
id: E9AFM1
db: uniprot

G protein subunit alpha i3
type: ProteinReference
xref: uniprot Q5I080 326
xref: PTHR10218:SF230
organism: Xenopus tropicalis

Opioid receptor mu 1
type: ProteinReference
xref: uniprot F7CDR6 9
xref: PTHR24229:SF7
organism: Monodelphis domestica

PTHR45627:SF9
type: RelationshipXref
id: PTHR45627:SF9
db: PANTHER Family
relationship type: By Homology

PTHR45627:SF6
type: RelationshipXref
id: PTHR45627:SF6
db: PANTHER Family
relationship type: By Homology

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 133

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F2Z3T8 71
organism: Rattus norvegicus

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot F6YZA3 86
type: UnificationXref
id: F6YZA3
db: uniprot

uniprot E2RGI5 60
type: UnificationXref
id: E2RGI5
db: uniprot

ncbitaxon 9031 37
type: UnificationXref
id: 9031
db: ncbitaxon

cAMP responsive element binding protein 1
type: ProteinReference
xref: uniprot F7FD05 26
xref: PTHR45879:SF1
organism: Monodelphis domestica

IC
type: EvidenceCodeVocabulary
xref: eco ECO:0000305 38

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot K7E376 116
organism: Monodelphis domestica

PENK isoform 3
type: DnaReference
xref: PTHR11438:SF3
organism: Pan troglodytes

Proenkephalin-A
type: ProteinReference
xref: PTHR11438:SF3
xref: uniprot G7MZE3 215
organism: Macaca mulatta

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5
type: ProteinReference
xref: uniprot Q80SZ7 200
organism: Mus musculus

uniprot F6R267 213
type: UnificationXref
id: F6R267
db: uniprot

uniprot A3KMS9 225
type: UnificationXref
id: A3KMS9
db: uniprot

Proenkephalin a
type: DnaReference
xref: PTHR11438:SF3
organism: Danio rerio

uniprot F6PVT7 77
type: UnificationXref
id: F6PVT7
db: uniprot

uniprot P54313 144
type: UnificationXref
id: P54313
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot Q90Z40 202
organism: Danio rerio

PARTICIPANT STOICHIOMETRY re2 392
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re2 393
type: Stoichiometry
physical entity: AC
stoichiometric coefficient: 1.0

uniprot Q6PH57 189
type: UnificationXref
id: Q6PH57
db: uniprot

uniprot P50154 141
type: UnificationXref
id: P50154
db: uniprot

uniprot E2RRD1 229
type: UnificationXref
id: E2RRD1
db: uniprot

uniprot F6PUU3 20
type: UnificationXref
id: F6PUU3
db: uniprot

uniprot E2R2S3 56
type: UnificationXref
id: E2R2S3
db: uniprot

Guanine nucleotide-binding protein subunit beta-4
type: ProteinReference
xref: uniprot F6ZIZ9 88
organism: Macaca mulatta

DISSOCIATION_LEFT__GTP-_Complex__GDP_G_Protein__i___GPCR__i__-RIGHT__Complex__GTP_G_Protein__i__-_GDP-_GPCR__i_-_re5
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 387
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 386
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 385
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 388
participant stoichiometry: PARTICIPANT STOICHIOMETRY re5 389
left: Complex (GDP/G-Protein (i)/ GPCR (i))
left: GTP
interaction type: DISSOCIATION
right: GDP
right: GPCR (i)
right: Complex (GTP/G-Protein (i))

PANTHER Pathway P05913 1
type: UnificationXref
id: P05913
db: PANTHER Pathway

uniprot P27699 30
type: UnificationXref
id: P27699
db: uniprot

uniprot F7H6T7 104
type: UnificationXref
id: F7H6T7
db: uniprot

KNOWN_TRANSITION_OMITTED_LEFT__Complex__CREB_Protoenkephalin_-RIGHT__preproenkephalin_mRNA-_re12
type: Conversion
conversion direction: LEFT_TO_RIGHT
xref: KNOWN TRANSITION OMITTED
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 397
participant stoichiometry: PARTICIPANT STOICHIOMETRY re12 396
left: Complex (CREB/Protoenkephalin)
interaction type: KNOWN_TRANSITION_OMITTED
right: preproenkephalin mRNA

uniprot Q03060 32
type: UnificationXref
id: Q03060
db: uniprot

Protein kinase A catalytic subunit isoform 2
type: ProteinReference
xref: PTHR24353:SF67
xref: uniprot E9AFM1 230
organism: Leishmania major

uniprot Q5BJ11 175
type: UnificationXref
id: Q5BJ11
db: uniprot

G Protein s s6 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: G-Protein (s)
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED
type: RelationshipTypeVocabulary

uniprot F7FD05 26
type: UnificationXref
id: F7FD05
db: uniprot

Delta-type opioid receptor
type: ProteinReference
xref: uniprot P41143 290
xref: PTHR24229:SF2
organism: Homo sapiens

G protein subunit beta 3
type: ProteinReference
xref: uniprot H2R3A6 113
organism: Pan troglodytes

Adenylate cyclase
type: ProteinReference
xref: uniprot F6ZAV4 340
xref: PTHR45627:SF6
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein (G protein), alpha-inhibiting activity polypeptide 1
type: ProteinReference
xref: PTHR10218:SF227
xref: uniprot F7A472 304
organism: Xenopus tropicalis

uniprot F6T0T9 235
type: UnificationXref
id: F6T0T9
db: uniprot

STATE_TRANSITION
type: InteractionVocabulary

uniprot P62872 147
type: UnificationXref
id: P62872
db: uniprot

OPRD1 isoform 1
type: ProteinReference
xref: uniprot H2PYH8 287
xref: PTHR24229:SF2
organism: Pan troglodytes

uniprot A9JTC8 295
type: UnificationXref
id: A9JTC8
db: uniprot

PARTICIPANT STOICHIOMETRY re6 384
type: Stoichiometry
physical entity: Complex (GTP/G-Protein)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: PTHR24353:SF82
xref: uniprot F7G4Q0 237
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re6 381
type: Stoichiometry
physical entity: Complex (GDP/G-Protein (s)/ GPCR (s))
stoichiometric coefficient: 1.0

PRKACG isoform 1
type: ProteinReference
xref: PTHR24353:SF137
xref: uniprot H2QXB9 241
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY re6 380
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 383
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re6 382
type: Stoichiometry
physical entity: GPCR (s)
stoichiometric coefficient: 1.0

KNOWN_TRANSITION_OMITTED
type: InteractionVocabulary

Adenylate cyclase
type: ProteinReference
xref: PTHR45627:SF9
xref: uniprot F7DL70 341
organism: Macaca mulatta

uniprot P63096 323
type: UnificationXref
id: P63096
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 231

cytosol
type: CellularLocationVocabulary
xref: GO GO:0005829 2

GO GO:0005829 2
type: UnificationXref
id: GO:0005829
db: GO

Enkephalin release
type: Pathway
pathway component: STATE_TRANSITION_LEFT__CREB-RIGHT__CREB-_re4
pathway component: PHYSICAL_STIMULATION
pathway component: HETERODIMER_ASSOCIATION_LEFT__CREB-_preproenkephalin-RIGHT__Complex__CREB_Protoenkephalin_-_re11
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__Complex__CREB_Protoenkephalin_-RIGHT__preproenkephalin_mRNA-_re12
pathway component: DISSOCIATION_LEFT__GTP-_Complex__GDP_G_Protein__i___GPCR__i__-RIGHT__Complex__GTP_G_Protein__i__-_GDP-_GPCR__i_-_re5
pathway component: KNOWN_TRANSITION_OMITTED_LEFT__preproenkephalin_mRNA-RIGHT__Enkephalin-_re10
pathway component: STATE_TRANSITION_LEFT__ATP-RIGHT__cAMP-_re1
pathway component: DISSOCIATION_LEFT__GTP-_Complex__GDP_G_Protein__s___GPCR__s__-RIGHT__GPCR__s_-_GDP-_Complex__GTP_G_Protein_-_re6
pathway component: STATE_TRANSITION_LEFT__AC-RIGHT__AC-_re2
pathway component: STATE_TRANSITION_LEFT__PKA-RIGHT__PKA-_re7
xref: PANTHER Pathway P05913 1
comment: MODEL_NOTES=Panther Pathway: P05913 No pathway definition No pathway definition

GTP
type: SmallMolecule
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa9 350
cellular location: cytosol
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY re11 373
type: Stoichiometry
physical entity: CREB
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY re11 374
type: Stoichiometry
physical entity: preproenkephalin
stoichiometric coefficient: 1.0

ncbitaxon 9606 14
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot A0A0R4IFU8 19
type: UnificationXref
id: A0A0R4IFU8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZDB2 87
xref: PTHR10218:SF320
organism: Monodelphis domestica

PARTICIPANT STOICHIOMETRY re11 375
type: Stoichiometry
physical entity: Complex (CREB/Protoenkephalin)
stoichiometric coefficient: 1.0

uniprot P62874 149
type: UnificationXref
id: P62874
db: uniprot

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F7ERP8 97
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein subunit gamma
type: ProteinReference
xref: uniprot F6VPY1 81
organism: Ornithorhynchus anatinus

Guanine nucleotide-binding protein subunit beta
type: ProteinReference
xref: uniprot P36408 132
organism: Dictyostelium discoideum

Cyclic AMP-responsive element-binding protein 1
type: ProteinReference
xref: uniprot P16220 29
xref: PTHR45879:SF1
organism: Homo sapiens

Mu-type opioid receptor
type: ProteinReference
xref: PTHR24229:SF7
xref: uniprot P35372 13
organism: Homo sapiens

cAMP-dependent protein kinase catalytic subunit beta isoform 1
type: ProteinReference
xref: PTHR24353:SF116
xref: uniprot F7EBQ5 236
organism: Macaca mulatta

uniprot E2RJB3 62
type: UnificationXref
id: E2RJB3
db: uniprot

uniprot E9FUX0 63
type: UnificationXref
id: E9FUX0
db: uniprot

uniprot Q7PPI8 274
type: UnificationXref
id: Q7PPI8
db: uniprot