uniprot P70615 233
type: UnificationXref
id: P70615
db: uniprot

Poly [ADP-ribose] polymerase 2
type: ProteinReference
xref: PTHR10459:SF60
xref: uniprot Q9UGN5 86
organism: Homo sapiens

uniprot G3X7B5 161
type: UnificationXref
id: G3X7B5
db: uniprot

TRANSPORT_LEFT__Bid-RIGHT__Bid-_r56
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 379
participant stoichiometry: PARTICIPANT STOICHIOMETRY r56 378
left: Bid
interaction type: TRANSPORT
right: Bid

Caspase-6
type: ProteinReference
xref: PTHR10454:SF206
xref: uniprot O35397 41
organism: Rattus norvegicus

FAS protein
type: ProteinReference
xref: uniprot A5D7R0 150
xref: PTHR46874:SF1
organism: Bos taurus

FasL s12 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FasL
stoichiometric coefficient: 2.0

ncbitaxon 224911 271
type: UnificationXref
id: 224911
db: ncbitaxon

uniprot Q29RM7 112
type: UnificationXref
id: Q29RM7
db: uniprot

uniprot Q60604 144
type: UnificationXref
id: Q60604
db: uniprot

uniprot G3N186 61
type: UnificationXref
id: G3N186
db: uniprot

ncbitaxon 559292 268
type: UnificationXref
id: 559292
db: ncbitaxon

uniprot Q0DJC3 272
type: UnificationXref
id: Q0DJC3
db: uniprot

nucleus
type: CellularLocationVocabulary
xref: GO GO:0005634 4

Os05g0301700 protein
type: ProteinReference
xref: uniprot Q0DJC3 272
xref: PTHR10266:SF11
organism: Oryza sativa

Adseverin
type: ProteinReference
xref: PTHR11977:SF78
xref: uniprot A2VE17 127
organism: Bos taurus

Caspase8
type: Protein
entity reference: Caspase8
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: uniprot G3V749 62
xref: PTHR10459:SF60
organism: Rattus norvegicus

uniprot F6Q273 219
type: UnificationXref
id: F6Q273
db: uniprot

ASK1
type: Protein
entity reference: ASK1
feature: ASK1 s6 a34 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ASK1
type: ProteinReference
xref: P00614
standard name: Apoptosis signal regulating kinase 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.ASK1
comment: ENTITY_REFERENCE_NOTES=Long Name: Apoptosis signal regulating kinase 1 Synonym: MAP3K5,Mitogen activated protein kinase kinase kinase 5 Accession: P00614
member entity reference: Uncharacterized protein
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-1
member entity reference: RAC serine/threonine-protein kinase
member entity reference: MAP3K5 isoform 1
member entity reference: Mitogen-activated protein kinase kinase kinase 5

ncbitaxon 284812 264
type: UnificationXref
id: 284812
db: ncbitaxon

ICAD s5 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: ICAD
stoichiometric coefficient: 1.0

Tumor necrosis factor receptor superfamily member 6
type: ProteinReference
xref: PTHR46874:SF1
xref: uniprot Q63199 153
organism: Rattus norvegicus

Caspase-9
type: ProteinReference
xref: uniprot P55211 11
xref: PTHR10454:SF157
organism: Homo sapiens

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P79996 198
xref: PTHR24055:SF172
organism: Gallus gallus

Caspase-7
type: ProteinReference
xref: PTHR10454:SF31
xref: uniprot P55210 37
organism: Homo sapiens

ncbitaxon 10116 17
type: UnificationXref
id: 10116
db: ncbitaxon

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot P55213 51
organism: Rattus norvegicus

Caspase-6
type: ProteinReference
xref: PTHR10454:SF206
xref: uniprot P55212 103
organism: Homo sapiens

ATP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

a124_degraded
type: PhysicalEntity
cellular location: nucleus
comment: SPECIES_TYPE=DEGRADED

Lamin Dm0
type: ProteinReference
xref: uniprot P08928 227
xref: PTHR45721:SF11
organism: Drosophila melanogaster

Scinderin
type: ProteinReference
xref: uniprot H2QU73 134
xref: PTHR11977:SF78
organism: Pan troglodytes

uniprot F1QLH0 21
type: UnificationXref
id: F1QLH0
db: uniprot

CytochromeC
type: Protein
entity reference: CytochromeC
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

Mus musculus
type: BioSource
xref: ncbitaxon 10090 15

Tumor necrosis factor ligand superfamily member 6
type: ProteinReference
xref: PTHR11471:SF33
xref: uniprot P41047 243
organism: Mus musculus

uniprot Q3SX14 143
type: UnificationXref
id: Q3SX14
db: uniprot

FAS signaling pathway
type: Pathway
pathway component: HETERODIMER_ASSOCIATION_LEFT__Complex__Fas_Fas_-_Complex__FasL_FasL_-RIGHT__Complex__FasL_FasL__Fas_Fas_-_r51
pathway component: TRANSPORT_LEFT__CAD-RIGHT__CAD-_r37
pathway component: STATE_TRANSITION_LEFT__MKK4-_ATP-RIGHT__ADP-_MKK4-_r11
pathway component: TRUNCATION_LEFT__Pro_Caspase10-RIGHT__?-_Caspase10-_r61
pathway component: DISSOCIATION_LEFT__Complex__ICAD_CAD_-RIGHT__ICAD-_CAD-_r41
pathway component: TRUNCATION_LEFT__Pro_Caspase8-RIGHT__?-_Caspase8-_r60
pathway component: TRUNCATION_LEFT__Pro_Caspase3-RIGHT__?-_Caspase3-_r58
pathway component: STATE_TRANSITION_LEFT__ICAD-RIGHT__a62_degraded-_r44
pathway component: STATE_TRANSITION_LEFT__Nuclear_Lamin-RIGHT__Nuclear_Lamin-_r66
pathway component: STATE_TRANSITION_LEFT__Gelsolin-RIGHT__Gelsolin-_r64
pathway component: STATE_TRANSITION_LEFT__c_Jun-_ATP-RIGHT__ADP-_c_Jun-_r13
pathway component: HETERODIMER_ASSOCIATION_LEFT__FasL-RIGHT__Complex__FasL_FasL_-_r3
pathway component: TRUNCATION_LEFT__Pro_Caspase6-RIGHT__Caspase6-_?-_r57
pathway component: TRANSPORT_LEFT__JNK-RIGHT__JNK-_r14
pathway component: HETERODIMER_ASSOCIATION_LEFT__Fas-RIGHT__Complex__Fas_Fas_-_r6
pathway component: TRUNCATION_LEFT__Apaf1-_Pro_Caspase9-RIGHT__Complex__Caspase9_Apaf1_-_?-_r63
pathway component: TRANSPORT_LEFT__Bid-RIGHT__Bid-_r56
pathway component: STATE_TRANSITION_LEFT__DNA-RIGHT__a124_degraded-_r59
pathway component: TRUNCATION_LEFT__Pro_Caspase7-RIGHT__?-_Caspase7-_r62
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__DAXX-_FADD-_Complex__FasL_FasL__Fas_Fas_-_FAF1-RIGHT__Complex__FasL_Fas__FasL_Fas__FADD_DAXX__FAF1_-_r53
pathway component: STATE_TRANSITION_LEFT__JNK-_ATP-RIGHT__ADP-_JNK-_r12
pathway component: STATE_TRANSITION_LEFT__PARP-RIGHT__PARP-_r65
pathway component: STATE_TRANSITION_LEFT__ASK1-_ATP-RIGHT__ASK1-_ADP-_r10
xref: PANTHER Pathway P00020 1
comment: MODEL_NOTES=Panther Pathway: P00020 The Fas receptor (CD95) mediates apoptotic signaling intiated by interaction with surface expressed FasL on other cells. The Fas-FasL interaction plays an important role in the immune system, and loss of function mutations in the Fas signaling pathway can result in hyper-proliferation of cells and autoimmunity. Upon Fas-FasL interaction, the apoptotic program is mediated by recruitment of signaling adaptor molecules to the Fas receptor via a death domain. This leads to the activation of a proteolytic cascade of specific proteases termed caspases. The activated caspases cleave a variety of cellular substrates that lead to morphological changes, DNA fragmentation, and ultimately cell death. Website=http://stke.sciencemag.org/cgi/cm/stkecm;CMP_7966 Website=http://www.biocarta.com/pathfiles/h_fasPathway.asp

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q7QK56 169
organism: Anopheles gambiae

Apaf1
type: Protein
entity reference: Apaf1
feature: COMPLEX PARTICIPANT BINDING FEATURE s11 sa8 301
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Caspase7
type: Protein
entity reference: Caspase7
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ADP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

FAS-associated death domain protein
type: ProteinReference
xref: uniprot Q8R2E7 287
xref: PTHR15077:SF9
organism: Rattus norvegicus

ncbitaxon 9913 35
type: UnificationXref
id: 9913
db: ncbitaxon

uniprot Q8R2E7 287
type: UnificationXref
id: Q8R2E7
db: uniprot

DAXX
type: ProteinReference
xref: P00602
standard name: Death-associated protein 6
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: DAXX Synonym: Synonym not specified Accession: P00602
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.DAXX
member entity reference: DAXX isoform 1
member entity reference: Death domain-associated protein 6
member entity reference: Death domain-associated protein 6 isoform a

uniprot F7GE72 60
type: UnificationXref
id: F7GE72
db: uniprot

PARTICIPANT STOICHIOMETRY r61 339
type: Stoichiometry
physical entity: Caspase10
stoichiometric coefficient: 1.0

JNK
type: Protein
entity reference: JNK
feature: ACTIVE 31
feature: JNK s70 a49 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r61 338
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

Pro-Caspase10
type: Protein
entity reference: Pro-Caspase10
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r61 337
type: Stoichiometry
physical entity: Pro-Caspase10
stoichiometric coefficient: 1.0

Transcription factor AP-1
type: ProteinReference
xref: uniprot O77627 91
xref: PTHR11462:SF8
organism: Bos taurus

uniprot A0A2I3TG87 149
type: UnificationXref
id: A0A2I3TG87
db: uniprot

uniprot A0A2I3SBZ3 33
type: UnificationXref
id: A0A2I3SBZ3
db: uniprot

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 83

Apoptotic protease-activating factor 1
type: ProteinReference
xref: uniprot O14727 44
xref: PTHR22845:SF5
organism: Homo sapiens

uniprot A0A2I3SPU3 18
type: UnificationXref
id: A0A2I3SPU3
db: uniprot

uniprot B8JK21 47
type: UnificationXref
id: B8JK21
db: uniprot

uniprot P07142 266
type: UnificationXref
id: P07142
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RGZ3 32
xref: PTHR10454:SF31
organism: Macaca mulatta

Lamin A/C
type: ProteinReference
xref: uniprot F1MYG5 216
xref: PTHR45721:SF5
organism: Bos taurus

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QK27 5
xref: PTHR10454:SF157
organism: Macaca mulatta

uniprot A0A3Q1LWJ8 176
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot O93417 49
organism: Gallus gallus

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: uniprot F7EMW7 59
xref: PTHR10459:SF80
organism: Macaca mulatta

uniprot F1P630 181
type: UnificationXref
id: F1P630
db: uniprot

uniprot H2QRE7 225
type: UnificationXref
id: H2QRE7
db: uniprot

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot O59680 263
organism: Schizosaccharomyces pombe

uniprot A0A0R4IKK9 173
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7DGQ2 24
xref: PTHR10454:SF8
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_Caspase3-RIGHT__?-_Caspase3-_r58
controller: Caspase8

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 10

Fas (TNFRSF6) associated factor 1
type: ProteinReference
xref: PTHR23322:SF56
xref: uniprot Q29RM7 112
organism: Bos taurus

uniprot P36940 242
type: UnificationXref
id: P36940
db: uniprot

uniprot F7DMP6 261
type: UnificationXref
id: F7DMP6
db: uniprot

uniprot F1Q2M3 57
type: UnificationXref
id: F1Q2M3
db: uniprot

Lamin L3
type: ProteinReference
xref: PTHR45721:SF4
xref: uniprot A0A2R8RV77 207
organism: Danio rerio

uniprot Q9FK91 84
type: UnificationXref
id: Q9FK91
db: uniprot

uniprot O89110 28
type: UnificationXref
id: O89110
db: uniprot

ncbitaxon 13616 110
type: UnificationXref
id: 13616
db: ncbitaxon

uniprot B0UXY9 107
type: UnificationXref
id: B0UXY9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F1NXP6 19
xref: PTHR10454:SF162
organism: Gallus gallus

uniprot P55211 11
type: UnificationXref
id: P55211
db: uniprot

c-Jun
type: ProteinReference
xref: P00601
comment: ENTITY_REFERENCE_NOTES=Long Name: c-Jun Synonym: Synonym not specified Accession: P00601
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.c-Jun
member entity reference: Transcription factor AP-1
member entity reference: Jun proto-oncogene
member entity reference: Jun proto-oncogene, AP-1 transcription factor subunit

uniprot E2RJX4 158
type: UnificationXref
id: E2RJX4
db: uniprot

Apaf1
type: Protein
entity reference: Apaf1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Stress-activated protein kinase jnk-1
type: ProteinReference
xref: uniprot Q8WQG9 201
xref: PTHR24055:SF341
organism: Caenorhabditis elegans

Macrophage-capping protein
type: ProteinReference
xref: PTHR11977:SF29
xref: uniprot P24452 139
organism: Mus musculus

CASP7 isoform 1
type: ProteinReference
xref: PTHR10454:SF31
xref: uniprot A0A2I3SBZ3 33
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q2TY19 177
xref: PTHR24055:SF222
organism: Gallus gallus

Lamin B3
type: ProteinReference
xref: uniprot A4IHY3 210
xref: PTHR45721:SF4
organism: Xenopus tropicalis

Fas cell surface death receptor
type: ProteinReference
xref: uniprot A0A2I3TG87 149
organism: Pan troglodytes

JNK
type: Protein
entity reference: JNK
feature: ACTIVE 31
feature: JNK s28 a8 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

FASLG isoform 1
type: ProteinReference
xref: PTHR11471:SF33
xref: uniprot H2Q0M2 241
organism: Pan troglodytes

FAS-associated factor 1
type: ProteinReference
xref: PTHR23322:SF56
xref: uniprot Q9UNN5 115
organism: Homo sapiens

Bid
type: Protein
feature: ACTIVE 31
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

MKK4
type: ProteinReference
xref: P00610
standard name: Mitogen-activated protein kinase kinase 4
comment: ENTITY_REFERENCE_NOTES=Long Name: Mitogen-activated protein kinase kinase 4 Synonym: JNK-activated kinase 1,JNKK1,MAP2K4,MAPKK4,MEK4,MKK4,SAPK/ERK kinase 1,SEK1 Accession: P00610
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.MKK4
member entity reference: MAP kinase kinase 4, isoform A
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase 4A
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: MAP2K4 protein
member entity reference: Mitogen-activated protein kinase kinase 4
member entity reference: MAP2K4 isoform 3

uniprot Q9UKK3 87
type: UnificationXref
id: Q9UKK3
db: uniprot

Poly [ADP-ribose] polymerase 2
type: ProteinReference
xref: PTHR10459:SF60
xref: uniprot Q11207 74
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r57 376
type: Stoichiometry
physical entity: Caspase6
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r57 377
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

Cytochrome c1
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9FQ96 278
organism: Chlamydomonas reinhardtii

PARTICIPANT STOICHIOMETRY r57 375
type: Stoichiometry
physical entity: Pro-Caspase6
stoichiometric coefficient: 1.0

Bid
type: Protein
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F1MYG5 216
type: UnificationXref
id: F1MYG5
db: uniprot

FAS-associated death domain protein
type: ProteinReference
xref: uniprot Q61160 286
xref: PTHR15077:SF9
organism: Mus musculus

uniprot Q99N34 253
type: UnificationXref
id: Q99N34
db: uniprot

uniprot F6YQA9 222
type: UnificationXref
id: F6YQA9
db: uniprot

Pro-Caspase7
type: Protein
entity reference: Pro-Caspase7
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O93417 49
type: UnificationXref
id: O93417
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK4-_ATP-RIGHT__ADP-_MKK4-_r11
controller: ASK1

STATE_TRANSITION_LEFT__JNK-_ATP-RIGHT__ADP-_JNK-_r12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 353
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 354
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 356
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 355
left: JNK
left: ATP
interaction type: STATE_TRANSITION
right: JNK
right: ADP

uniprot Q4QIT8 274
type: UnificationXref
id: Q4QIT8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7B5L8 187
xref: PTHR24055:SF172
organism: Ornithorhynchus anatinus

PTHR46874:SF1
type: RelationshipXref
id: PTHR46874:SF1
db: PANTHER Family
relationship type: By Homology

Fas
type: Protein
entity reference: Fas

PTHR10454:SF8
type: RelationshipXref
id: PTHR10454:SF8
db: PANTHER Family
relationship type: By Homology

uniprot H2Q0M2 241
type: UnificationXref
id: H2Q0M2
db: uniprot

STATE_TRANSITION_LEFT__Gelsolin-RIGHT__Gelsolin-_r64
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 328
participant stoichiometry: PARTICIPANT STOICHIOMETRY r64 329
left: Gelsolin
interaction type: STATE_TRANSITION
right: Gelsolin

HETERODIMER_ASSOCIATION_LEFT__FasL-RIGHT__Complex__FasL_FasL_-_r3
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 369
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 368
left: FasL
interaction type: HETERODIMER_ASSOCIATION
right: Complex (FasL/FasL)

ncbitaxon 9606 12
type: UnificationXref
id: 9606
db: ncbitaxon

ncbitaxon 9598 10
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot A0A2J8NYK5 96
type: UnificationXref
id: A0A2J8NYK5
db: uniprot

Poly [ADP-ribose] polymerase 2
type: ProteinReference
xref: PTHR10459:SF60
xref: uniprot Q09525 72
organism: Caenorhabditis elegans

DNA fragmentation factor, beta polypeptide (caspase-activated DNase)
type: ProteinReference
xref: PTHR13067:SF2
xref: uniprot Q1L9C6 252
organism: Danio rerio

uniprot A5PJP8 117
type: UnificationXref
id: A5PJP8
db: uniprot

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: PTHR10459:SF66
xref: uniprot H2QMQ4 64
organism: Pan troglodytes

uniprot P49187 196
type: UnificationXref
id: P49187
db: uniprot

CYtochrome C
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q18853 273
organism: Caenorhabditis elegans

uniprot F6XP81 160
type: UnificationXref
id: F6XP81
db: uniprot

MODULATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r41 365
type: Stoichiometry
physical entity: Complex (ICAD/CAD)
stoichiometric coefficient: 1.0

Protein mono-ADP-ribosyltransferase PARP3
type: ProteinReference
xref: PTHR10459:SF66
xref: uniprot Q3ULW8 76
organism: Mus musculus

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 6

00696
type: UnificationXref
id: MOD:00696
db: mod

Fas
type: Protein
entity reference: Fas
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

AGAP008015-PA
type: ProteinReference
xref: uniprot Q7PNC2 237
organism: Anopheles gambiae

uniprot Q924K2 114
type: UnificationXref
id: Q924K2
db: uniprot

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: uniprot B1NA68 118
xref: PTHR48013:SF15
organism: Danio rerio

uniprot H2Q4B6 284
type: UnificationXref
id: H2Q4B6
db: uniprot

uniprot P53779 197
type: UnificationXref
id: P53779
db: uniprot

PTHR13067:SF2
type: RelationshipXref
id: PTHR13067:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q9VAM8 283
type: UnificationXref
id: Q9VAM8
db: uniprot

ncbitaxon 3055 279
type: UnificationXref
id: 3055
db: ncbitaxon

uniprot P18870 95
type: UnificationXref
id: P18870
db: uniprot

PARTICIPANT STOICHIOMETRY r62 334
type: Stoichiometry
physical entity: Pro-Caspase7
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r62 335
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r62 336
type: Stoichiometry
physical entity: Caspase7
stoichiometric coefficient: 1.0

Transcription factor AP-1
type: ProteinReference
xref: uniprot P05627 93
xref: PTHR11462:SF8
organism: Mus musculus

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q9DGD9 203
xref: PTHR24055:SF222
organism: Danio rerio

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_Caspase8-RIGHT__?-_Caspase8-_r60
controller: Complex (FasL/Fas/ FasL/Fas/ FADD/DAXX/ FAF1)

FAF1 isoform 1
type: ProteinReference
xref: PTHR23322:SF56
xref: uniprot A0A2I3SXQ0 106
organism: Pan troglodytes

DISSOCIATION
type: RelationshipTypeVocabulary

ncbitaxon 6239 73
type: UnificationXref
id: 6239
db: ncbitaxon

uniprot F7HQ21 133
type: UnificationXref
id: F7HQ21
db: uniprot

Probable cytochrome c1
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9HVY6 280
organism: Pseudomonas aeruginosa

PARTICIPANT STOICHIOMETRY r41 367
type: Stoichiometry
physical entity: CAD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r41 366
type: Stoichiometry
physical entity: ICAD
stoichiometric coefficient: 1.0

uniprot P05627 93
type: UnificationXref
id: P05627
db: uniprot

Lamin B2
type: ProteinReference
xref: uniprot F6VYL3 221
xref: PTHR45721:SF2
organism: Xenopus tropicalis

Complex (FasL/FasL/ Fas/Fas)
type: Complex
component: FasL
component: Fas
feature: COMPLEX BINDING FEATURE s90 a101 312
feature: COMPLEX BINDING FEATURE s90 a101 310
cellular location: cytoplasm

uniprot A0A2R8RV77 207
type: UnificationXref
id: A0A2R8RV77
db: uniprot

uniprot Q7QBC7 80
type: UnificationXref
id: Q7QBC7
db: uniprot

uniprot Q9HVY6 280
type: UnificationXref
id: Q9HVY6
db: uniprot

uniprot Q7PZJ0 238
type: UnificationXref
id: Q7PZJ0
db: uniprot

uniprot Q9V3H0 254
type: UnificationXref
id: Q9V3H0
db: uniprot

Caspase6
type: Protein
entity reference: Caspase6
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

TRUNCATION_LEFT__Pro_Caspase3-RIGHT__?-_Caspase3-_r58
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 374
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 373
participant stoichiometry: PARTICIPANT STOICHIOMETRY r58 372
left: Pro-Caspase3
interaction type: TRUNCATION
right: Caspase3
right: ?

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QS62 191
xref: PTHR24055:SF172
organism: Pan troglodytes

Poly [ADP-ribose] polymerase 1
type: ProteinReference
xref: uniprot P09874 68
xref: PTHR10459:SF80
organism: Homo sapiens

uniprot Q7QK56 169
type: UnificationXref
id: Q7QK56
db: uniprot

Poly [ADP-ribose] polymerase 1
type: ProteinReference
xref: uniprot P11103 69
xref: PTHR10459:SF80
organism: Mus musculus

uniprot Q9FQ96 278
type: UnificationXref
id: Q9FQ96
db: uniprot

uniprot H2QJ86 25
type: UnificationXref
id: H2QJ86
db: uniprot

Bradyrhizobium diazoefficiens
type: BioSource
xref: ncbitaxon 224911 271

Cytochrome c1 2, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9FKS5 277
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r13 349
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 348
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 347
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

CASP8 and FADD-like apoptosis regulator
type: ProteinReference
xref: uniprot A0A2I3SPU3 18
xref: PTHR10454:SF8
organism: Pan troglodytes

ncbitaxon 3702 75
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot O14727 44
type: UnificationXref
id: O14727
db: uniprot

CASP8 and FADD-like apoptosis regulator
type: ProteinReference
xref: PTHR10454:SF8
xref: uniprot O35732 27
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A4FV00 178
xref: PTHR24055:SF162
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r53 317
type: Stoichiometry
physical entity: FAF1
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7CYE3 189
xref: PTHR24055:SF162
organism: Xenopus tropicalis

PARTICIPANT STOICHIOMETRY r53 316
type: Stoichiometry
physical entity: Complex (FasL/FasL/ Fas/Fas)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 315
type: Stoichiometry
physical entity: FADD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r53 314
type: Stoichiometry
physical entity: DAXX
stoichiometric coefficient: 1.0

Adseverin
type: ProteinReference
xref: PTHR11977:SF78
xref: uniprot Q60604 144
organism: Mus musculus

uniprot I0FRT6 162
type: UnificationXref
id: I0FRT6
db: uniprot

uniprot P48679 232
type: UnificationXref
id: P48679
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot P51131 270
type: UnificationXref
id: P51131
db: uniprot

uniprot Q92851 46
type: UnificationXref
id: Q92851
db: uniprot

uniprot B3DFN3 212
type: UnificationXref
id: B3DFN3
db: uniprot

PARTICIPANT STOICHIOMETRY r53 318
type: Stoichiometry
physical entity: Complex (FasL/Fas/ FasL/Fas/ FADD/DAXX/ FAF1)
stoichiometric coefficient: 1.0

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 279

Pro-Caspase3
type: Protein
entity reference: Pro-Caspase3
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

FAF1 s30 sa19 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FAF1
stoichiometric coefficient: 1.0

uniprot Q61160 286
type: UnificationXref
id: Q61160
db: uniprot

Complex (FasL/FasL)
type: Complex
component: FasL
feature: COMPLEX BINDING FEATURE s16 a28 308
cellular location: cytoplasm

Caspase6
type: ProteinReference
xref: P00596
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase6 Synonym: Casp6,MCH2 Accession: P00596
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase6
member entity reference: Caspase-6
member entity reference: AT03047p
member entity reference: Caspase 6

Pro-Caspase6
type: Protein
entity reference: Pro-Caspase6
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: PTHR23322:SF56
xref: uniprot F6QTM2 108
organism: Macaca mulatta

Lamin B2
type: ProteinReference
xref: PTHR45721:SF2
xref: uniprot A0A3Q2U596 209
organism: Gallus gallus

eco ECO:0000316 13
type: UnificationXref
id: ECO:0000316
db: eco

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_Caspase3-RIGHT__?-_Caspase3-_r58
controller: Complex (Caspase9/Apaf1)

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q8UUX0 171
organism: Danio rerio

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 180

CAD s9 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: CAD
stoichiometric coefficient: 1.0

ncbitaxon 10090 15
type: UnificationXref
id: 10090
db: ncbitaxon

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 73

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__c_Jun-_ATP-RIGHT__ADP-_c_Jun-_r13
controller: JNK

uniprot A0A2I3SXQ0 106
type: UnificationXref
id: A0A2I3SXQ0
db: uniprot

uniprot P20700 229
type: UnificationXref
id: P20700
db: uniprot

DFFB isoform 3
type: ProteinReference
xref: PTHR13067:SF2
xref: uniprot K6ZGT0 249
organism: Pan troglodytes

uniprot F6Y3P9 131
type: UnificationXref
id: F6Y3P9
db: uniprot

uniprot Q21253 142
type: UnificationXref
id: Q21253
db: uniprot

PARTICIPANT STOICHIOMETRY r11 360
type: Stoichiometry
physical entity: MKK4
stoichiometric coefficient: 1.0

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_Caspase7-RIGHT__?-_Caspase7-_r62
controller: Caspase8

PARTICIPANT STOICHIOMETRY r13 350
type: Stoichiometry
physical entity: c-Jun
stoichiometric coefficient: 1.0

eco ECO:0000250 7
type: UnificationXref
id: ECO:0000250
db: eco

Uncharacterized protein
type: ProteinReference
xref: PTHR11977:SF35
xref: uniprot F7HQ21 133
organism: Macaca mulatta

uniprot H2Q091 224
type: UnificationXref
id: H2Q091
db: uniprot

ACTIVE 31
type: EntityFeature
comment: Active state

PARTICIPANT STOICHIOMETRY r11 358
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 359
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

MAP kinase kinase 4, isoform A
type: ProteinReference
xref: uniprot O61444 122
xref: PTHR48013:SF15
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r11 357
type: Stoichiometry
physical entity: MKK4
stoichiometric coefficient: 1.0

uniprot P49186 195
type: UnificationXref
id: P49186
db: uniprot

PARTICIPANT STOICHIOMETRY r59 370
type: Stoichiometry
physical entity: DNA
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r59 371
type: Stoichiometry
physical entity: a124_degraded
stoichiometric coefficient: 1.0

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: uniprot F6X747 58
xref: PTHR10459:SF80
organism: Xenopus tropicalis

uniprot F1Q5F3 218
type: UnificationXref
id: F1Q5F3
db: uniprot

PTHR10266:SF3
type: RelationshipXref
id: PTHR10266:SF3
db: PANTHER Family
relationship type: By Homology

uniprot Q7PNC2 237
type: UnificationXref
id: Q7PNC2
db: uniprot

Caspase9
type: ProteinReference
xref: P00593
standard name: Caspase 9
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase9
comment: ENTITY_REFERENCE_NOTES=
member entity reference: CASP9 isoform 4
member entity reference: Uncharacterized protein
member entity reference: Caspase-9
member entity reference: Caspase 9, isoform CRA_a

Uncharacterized protein
type: ProteinReference
xref: PTHR23322:SF56
xref: uniprot A0A1D5NY89 105
organism: Gallus gallus

uniprot Q865V6 147
type: UnificationXref
id: Q865V6
db: uniprot

PARP
type: Protein
entity reference: PARP
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot F1PBB6 119
xref: PTHR48013:SF15
organism: Canis lupus familiaris

uniprot F6VYL3 221
type: UnificationXref
id: F6VYL3
db: uniprot

TRANSPORT
type: RelationshipTypeVocabulary

…
type: Stoichiometry
physical entity: FasL
stoichiometric coefficient: 4.0

GSN isoform 3
type: ProteinReference
xref: PTHR11977:SF29
xref: uniprot H2QXT3 135
organism: Pan troglodytes

Transcription factor AP-1
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot P18870 95
organism: Gallus gallus

PTHR24055:SF222
type: RelationshipXref
id: PTHR24055:SF222
db: PANTHER Family
relationship type: By Homology

Pro-Caspase6
type: ProteinReference
xref: P00607
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase6 Synonym: Casp6,MCH2 Accession: P00607
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase6
member entity reference: Caspase-6
member entity reference: AT03047p
member entity reference: Caspase 6

TRUNCATION_LEFT__Pro_Caspase6-RIGHT__Caspase6-_?-_r57
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 377
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 376
participant stoichiometry: PARTICIPANT STOICHIOMETRY r57 375
left: Pro-Caspase6
interaction type: TRUNCATION
right: Caspase6
right: ?

uniprot P79996 198
type: UnificationXref
id: P79996
db: uniprot

Scinderin-like a
type: ProteinReference
xref: uniprot A0A0R4IQ11 125
xref: PTHR11977:SF27
organism: Danio rerio

JNK s28 a8 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

STATE_TRANSITION_LEFT__ICAD-RIGHT__a62_degraded-_r44
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 352
participant stoichiometry: PARTICIPANT STOICHIOMETRY r44 351
left: ICAD
interaction type: STATE_TRANSITION
right: a62_degraded

PARP
type: Protein
entity reference: PARP
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P47196 167
type: UnificationXref
id: P47196
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ASK1-_ATP-RIGHT__ASK1-_ADP-_r10
controller: Complex (FasL/Fas/ FasL/Fas/ FADD/DAXX/ FAF1)

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 214

FAF1
type: ProteinReference
xref: P00609
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.FAF1
comment: ENTITY_REFERENCE_NOTES=Long Name: FAF1 Synonym: Synonym not specified Accession: P00609
member entity reference: Fas (TNFRSF6)-associated factor 1
member entity reference: FAF1 isoform 1
member entity reference: Uncharacterized protein
member entity reference: FAS-associated factor 1
member entity reference: Caspar, isoform A
member entity reference: Fas (TNFRSF6) associated factor 1

uniprot Q21443 236
type: UnificationXref
id: Q21443
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK-_ATP-RIGHT__ADP-_JNK-_r12
controller: MKK4

ncbitaxon 7227 43
type: UnificationXref
id: 7227
db: ncbitaxon

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF20
xref: uniprot P45985 123
organism: Homo sapiens

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 7

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 193
xref: PTHR24055:SF222
organism: Homo sapiens

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P45984 194
xref: PTHR24055:SF172
organism: Homo sapiens

MKK4 s7 a35 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot P17325 94
type: UnificationXref
id: P17325
db: uniprot

Protein mono-ADP-ribosyltransferase PARP3
type: ProteinReference
xref: PTHR10459:SF66
xref: uniprot Q9Y6F1 88
organism: Homo sapiens

uniprot P45983 193
type: UnificationXref
id: P45983
db: uniprot

uniprot H2QU73 134
type: UnificationXref
id: H2QU73
db: uniprot

Cytochrome c1
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot E2REM0 260
organism: Canis lupus familiaris

ASK1 s26 a6 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

ASK1
type: Protein
entity reference: ASK1
feature: ACTIVE 31
feature: ASK1 s26 a6 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q3ULW8 76
type: UnificationXref
id: Q3ULW8
db: uniprot

STATE_TRANSITION_LEFT__Nuclear_Lamin-RIGHT__Nuclear_Lamin-_r66
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 325
participant stoichiometry: PARTICIPANT STOICHIOMETRY r66 324
left: Nuclear Lamin
interaction type: STATE_TRANSITION
right: Nuclear Lamin

Pro-Caspase9
type: Protein
entity reference: Pro-Caspase9
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ADP
type: SmallMolecule
cellular location: nucleus
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 110

Gelsolin
type: ProteinReference
xref: uniprot Q68FP1 145
xref: PTHR11977:SF29
organism: Rattus norvegicus

uniprot F1NEL6 38
type: UnificationXref
id: F1NEL6
db: uniprot

TRANSPORT_LEFT__JNK-RIGHT__JNK-_r14
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 344
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 343
left: JNK
interaction type: TRANSPORT
right: JNK

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: PTHR10459:SF66
xref: uniprot Q5U2U3 77
organism: Rattus norvegicus

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot P00125 265
organism: Bos taurus

uniprot F1PBB6 119
type: UnificationXref
id: F1PBB6
db: uniprot

JNK s70 a49 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A8X1S0 179
type: UnificationXref
id: A8X1S0
db: uniprot

uniprot H2Q7A7 63
type: UnificationXref
id: H2Q7A7
db: uniprot

Macrophage-capping protein
type: ProteinReference
xref: uniprot Q865V6 147
xref: PTHR11977:SF29
organism: Bos taurus

PTHR10454:SF198
type: RelationshipXref
id: PTHR10454:SF198
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 186
xref: PTHR24055:SF222
organism: Macaca mulatta

uniprot A0A1D5QQZ2 205
type: UnificationXref
id: A0A1D5QQZ2
db: uniprot

ncbitaxon 208964 281
type: UnificationXref
id: 208964
db: ncbitaxon

uniprot P06396 137
type: UnificationXref
id: P06396
db: uniprot

uniprot F6WV79 184
type: UnificationXref
id: F6WV79
db: uniprot

uniprot Q9UER7 100
type: UnificationXref
id: Q9UER7
db: uniprot

Lamin-B1
type: ProteinReference
xref: uniprot P14733 228
xref: PTHR45721:SF3
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WV79 184
xref: PTHR24055:SF172
organism: Monodelphis domestica

PTHR19271:SF16
type: RelationshipXref
id: PTHR19271:SF16
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PARP-RIGHT__PARP-_r65
controller: Caspase7

PTHR10266:SF11
type: RelationshipXref
id: PTHR10266:SF11
db: PANTHER Family
relationship type: By Homology

FasL
type: Protein
entity reference: FasL

uniprot H2QCA7 121
type: UnificationXref
id: H2QCA7
db: uniprot

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: uniprot F1NL05 55
xref: PTHR10459:SF80
organism: Gallus gallus

Gelsolin
type: ProteinReference
xref: uniprot Q07171 141
xref: PTHR11977:SF55
organism: Drosophila melanogaster

STATE_TRANSITION_LEFT__ASK1-_ATP-RIGHT__ASK1-_ADP-_r10
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 362
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 363
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 364
participant stoichiometry: PARTICIPANT STOICHIOMETRY r10 361
left: ATP
left: ASK1
interaction type: STATE_TRANSITION
right: ASK1
right: ADP

c-Jun
type: Protein
entity reference: c-Jun
feature: c Jun s25 a38 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

PTHR46530:SF1
type: RelationshipXref
id: PTHR46530:SF1
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__DNA-RIGHT__a124_degraded-_r59
type: Degradation
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 370
participant stoichiometry: PARTICIPANT STOICHIOMETRY r59 371
left: DNA
interaction type: STATE_TRANSITION
right: a124_degraded

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot P08574 269
organism: Homo sapiens

Capping actin protein, gelsolin like
type: ProteinReference
xref: uniprot E2R413 128
xref: PTHR11977:SF29
organism: Canis lupus familiaris

MKK4
type: Protein
entity reference: MKK4
feature: MKK4 s7 a35 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__DNA-RIGHT__a124_degraded-_r59
controller: CAD

uniprot Q9VET9 42
type: UnificationXref
id: Q9VET9
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 75

FasL
type: ProteinReference
xref: P00617
standard name: Fas ligand
comment: ENTITY_REFERENCE_NOTES=Long Name: Fas ligand Synonym: APT1LG1,Apoptosis antigen ligand 1,FasL Accession: P00617
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.RECEPTOR.FasL
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Tumor necrosis factor ligand superfamily member 6
member entity reference: FASLG isoform 1

uniprot P09874 68
type: UnificationXref
id: P09874
db: uniprot

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: PTHR46530:SF1
xref: uniprot H2Q7A7 63
organism: Pan troglodytes

PTHR15077:SF9
type: RelationshipXref
id: PTHR15077:SF9
db: PANTHER Family
relationship type: By Homology

uniprot Q07171 141
type: UnificationXref
id: Q07171
db: uniprot

uniprot O59680 263
type: UnificationXref
id: O59680
db: uniprot

MKK4 s27 a7 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot P47809 124
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r66 324
type: Stoichiometry
physical entity: Nuclear Lamin
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r66 325
type: Stoichiometry
physical entity: Nuclear Lamin
stoichiometric coefficient: 1.0

JNK
type: ProteinReference
xref: P00615
standard name: c-Jun kinase
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.JNK
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: c-Jun kinase Synonym: JNK,SAPK,Stress-activated protein kinase Accession: P00615
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Stress-activated protein kinase jnk-1
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Stress-activated protein kinase JNK

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot K7CDC2 163
organism: Pan troglodytes

uniprot F1NL05 55
type: UnificationXref
id: F1NL05
db: uniprot

Caspase-8
type: ProteinReference
xref: uniprot O89110 28
xref: PTHR10454:SF162
organism: Mus musculus

uniprot P48023 244
type: UnificationXref
id: P48023
db: uniprot

uniprot F6Y4G8 185
type: UnificationXref
id: F6Y4G8
db: uniprot

Danio rerio
type: BioSource
xref: ncbitaxon 7955 22

uniprot D3ZLC1 215
type: UnificationXref
id: D3ZLC1
db: uniprot

uniprot D6XKS6 258
type: UnificationXref
id: D6XKS6
db: uniprot

CASP9 isoform 4
type: ProteinReference
xref: uniprot A0A2I3TJU8 9
xref: PTHR10454:SF157
organism: Pan troglodytes

uniprot P11103 69
type: UnificationXref
id: P11103
db: uniprot

uniprot F6R1R1 39
type: UnificationXref
id: F6R1R1
db: uniprot

Death domain-associated protein 6 isoform a
type: ProteinReference
xref: PTHR12766:SF7
xref: uniprot I0FPK1 97
organism: Macaca mulatta

PTHR10454:SF157
type: RelationshipXref
id: PTHR10454:SF157
db: PANTHER Family
relationship type: By Homology

STATE_TRANSITION_LEFT__MKK4-_ATP-RIGHT__ADP-_MKK4-_r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 358
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 357
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 360
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 359
left: ATP
left: MKK4
interaction type: STATE_TRANSITION
right: MKK4
right: ADP

FAS-associated factor 1
type: ProteinReference
xref: PTHR23322:SF56
xref: uniprot Q924K2 114
organism: Rattus norvegicus

Caspase-8
type: ProteinReference
xref: uniprot Q14790 29
xref: PTHR10454:SF162
organism: Homo sapiens

uniprot Q13158 285
type: UnificationXref
id: Q13158
db: uniprot

ncbitaxon 6238 180
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot A0A1D5NY89 105
type: UnificationXref
id: A0A1D5NY89
db: uniprot

uniprot G3V749 62
type: UnificationXref
id: G3V749
db: uniprot

Fas
type: Complex
component stoichiometry: Fas s14 sa11 STOICHIOMETRY ID COMPLEX
component: Fas
feature: COMPLEX PARTICIPANT BINDING FEATURE s14 sa11 313
cellular location: cytoplasm

Fas
type: Complex
component stoichiometry: Fas s20 sa14 STOICHIOMETRY ID COMPLEX
component: Fas
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa14 291
cellular location: cytoplasm

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P53779 197
xref: PTHR24055:SF162
organism: Homo sapiens

Fas
type: Complex
component stoichiometry: Fas s3 sa3 STOICHIOMETRY ID COMPLEX
component: Fas
feature: COMPLEX PARTICIPANT BINDING FEATURE s3 sa3 307
cellular location: cytoplasm

TRUNCATION_LEFT__Pro_Caspase7-RIGHT__?-_Caspase7-_r62
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 334
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 335
participant stoichiometry: PARTICIPANT STOICHIOMETRY r62 336
left: Pro-Caspase7
interaction type: TRUNCATION
right: ?
right: Caspase7

uniprot Q9LK29 282
type: UnificationXref
id: Q9LK29
db: uniprot

FADD
type: ProteinReference
xref: P00622
standard name: Fas-associating protein with death domain
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.FADD
comment: ENTITY_REFERENCE_NOTES=Long Name: Fas-associating protein with death domain Synonym: Synonym not specified Accession: P00622
member entity reference: FAS-associated death domain protein

PTHR10454:SF162
type: RelationshipXref
id: PTHR10454:SF162
db: PANTHER Family
relationship type: By Homology

uniprot P41047 243
type: UnificationXref
id: P41047
db: uniprot

TRUNCATION_LEFT__Pro_Caspase10-RIGHT__?-_Caspase10-_r61
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 338
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 337
participant stoichiometry: PARTICIPANT STOICHIOMETRY r61 339
left: Pro-Caspase10
interaction type: TRUNCATION
right: Caspase10
right: ?

c Jun s29 a37 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6XP81 160
organism: Xenopus tropicalis

PTHR11977:SF55
type: RelationshipXref
id: PTHR11977:SF55
db: PANTHER Family
relationship type: By Homology

Scinderin
type: ProteinReference
xref: PTHR11977:SF78
xref: uniprot F6T8Z7 130
organism: Macaca mulatta

Caspase10
type: ProteinReference
xref: P00606
standard name: Caspase 10
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase10
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase 10 Synonym: Casp10,FLICE2,MCH4 Accession: P00606
member entity reference: Caspase-10
member entity reference: Caspase 10

uniprot H2QS62 191
type: UnificationXref
id: H2QS62
db: uniprot

DNA fragmentation factor subunit beta
type: ProteinReference
xref: PTHR13067:SF2
xref: uniprot O54788 250
organism: Mus musculus

TRANSPORT_LEFT__CAD-RIGHT__CAD-_r37
type: TransportWithBiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRANSPORT
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 323
participant stoichiometry: PARTICIPANT STOICHIOMETRY r37 322
left: CAD
interaction type: TRANSPORT
right: CAD

CAD
type: Protein
entity reference: CAD
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

Stress-activated protein kinase JNK
type: ProteinReference
xref: uniprot P92208 199
xref: PTHR24055:SF341
organism: Drosophila melanogaster

uniprot Q5IS54 104
type: UnificationXref
id: Q5IS54
db: uniprot

P00593
type: UnificationXref
id: P00593
db: PANTHER Pathway Component

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LWJ8 176
xref: PTHR24055:SF222
organism: Bos taurus

P00595
type: UnificationXref
id: P00595
db: PANTHER Pathway Component

P00594
type: UnificationXref
id: P00594
db: PANTHER Pathway Component

P00597
type: UnificationXref
id: P00597
db: PANTHER Pathway Component

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 17

P00596
type: UnificationXref
id: P00596
db: PANTHER Pathway Component

uniprot Q7S7M3 82
type: UnificationXref
id: Q7S7M3
db: uniprot

P00598
type: UnificationXref
id: P00598
db: PANTHER Pathway Component

P00599
type: UnificationXref
id: P00599
db: PANTHER Pathway Component

PTHR11977:SF27
type: RelationshipXref
id: PTHR11977:SF27
db: PANTHER Family
relationship type: By Homology

PTHR11977:SF29
type: RelationshipXref
id: PTHR11977:SF29
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3RFE8 45
type: UnificationXref
id: A0A2I3RFE8
db: uniprot

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: uniprot K7C230 66
xref: PTHR10459:SF80
organism: Pan troglodytes

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

Fas s20 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fas
stoichiometric coefficient: 2.0

MAP2K4 isoform 3
type: ProteinReference
xref: uniprot H2QCA7 121
xref: PTHR48013:SF20
organism: Pan troglodytes

FADD
type: Protein
entity reference: FADD
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Caspase10
type: Protein
entity reference: Caspase10
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q7JUP3 113
type: UnificationXref
id: Q7JUP3
db: uniprot

PTHR11977:SF35
type: RelationshipXref
id: PTHR11977:SF35
db: PANTHER Family
relationship type: By Homology

uniprot H2QXT3 135
type: UnificationXref
id: H2QXT3
db: uniprot

Gelsolin
type: ProteinReference
xref: P00611
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Gelsolin Synonym: Synonym not specified Accession: P00611
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Gelsolin
member entity reference: Macrophage-capping protein
member entity reference: Gelsolin
member entity reference: Adseverin
member entity reference: GSN isoform 3
member entity reference: Scinderin
member entity reference: Uncharacterized protein
member entity reference: Scinderin-like a
member entity reference: Gelsolin-like protein 1
member entity reference: CAPG isoform 1
member entity reference: Capping actin protein, gelsolin like

Lamin B2
type: ProteinReference
xref: uniprot B3DFN3 212
xref: PTHR45721:SF2
organism: Danio rerio

uniprot Q1L9C6 252
type: UnificationXref
id: Q1L9C6
db: uniprot

uniprot A0A1D5PXC6 174
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: uniprot Q17941 168
organism: Caenorhabditis elegans

uniprot H2R0G7 192
type: UnificationXref
id: H2R0G7
db: uniprot

uniprot B1NA68 118
type: UnificationXref
id: B1NA68
db: uniprot

uniprot Q9UNN5 115
type: UnificationXref
id: Q9UNN5
db: uniprot

Prelamin-A/C
type: ProteinReference
xref: uniprot P02545 226
xref: PTHR45721:SF5
organism: Homo sapiens

uniprot Q9Y6F1 88
type: UnificationXref
id: Q9Y6F1
db: uniprot

CASP8 and FADD-like apoptosis regulator
type: ProteinReference
xref: uniprot O15519 26
xref: PTHR10454:SF8
organism: Homo sapiens

uniprot F6ZKB3 186
type: UnificationXref
id: F6ZKB3
db: uniprot

uniprot Q8WQG9 201
type: UnificationXref
id: Q8WQG9
db: uniprot

Caspase-9
type: ProteinReference
xref: uniprot Q8C3Q9 14
xref: PTHR10454:SF157
organism: Mus musculus

uniprot A0A2I3RZ31 175
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

TRUNCATION
type: InteractionVocabulary

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot G3X7B5 161
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r60 341
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

GO GO:0005737 3
type: UnificationXref
id: GO:0005737
db: GO

PARTICIPANT STOICHIOMETRY r60 342
type: Stoichiometry
physical entity: Caspase8
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Gene transcription
controller: c-Jun

Apaf1
type: ProteinReference
xref: P00597
standard name: Apoptotic protease activating factor1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Apoptotic protease activating factor1 Synonym: APAF1,APAF3,Apoptotic protease activating factor 3,CASP9 Accession: P00597
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Apaf1
member entity reference: Apoptotic protease-activating factor 1

MODULATION
type: Control
xref: MODULATION
controlled: TRANSPORT_LEFT__Bid-RIGHT__Bid-_r56
controller: Caspase8

PARTICIPANT STOICHIOMETRY r60 340
type: Stoichiometry
physical entity: Pro-Caspase8
stoichiometric coefficient: 1.0

uniprot Q9UGN5 86
type: UnificationXref
id: Q9UGN5
db: uniprot

GO GO:0005739 2
type: UnificationXref
id: GO:0005739
db: GO

uniprot Q6AYC4 146
type: UnificationXref
id: Q6AYC4
db: uniprot

uniprot Q03427 235
type: UnificationXref
id: Q03427
db: uniprot

By Homology
type: RelationshipTypeVocabulary

uniprot O35397 41
type: UnificationXref
id: O35397
db: uniprot

Tumor necrosis factor ligand superfamily member 6
type: ProteinReference
xref: PTHR11471:SF33
xref: uniprot P36940 242
organism: Rattus norvegicus

Prelamin-A/C
type: ProteinReference
xref: uniprot P48678 231
xref: PTHR45721:SF5
organism: Mus musculus

Prelamin-A/C
type: ProteinReference
xref: uniprot P48679 232
xref: PTHR45721:SF5
organism: Rattus norvegicus

CAD
type: ProteinReference
xref: P00618
standard name: Caspase-activated deoxyribonuclease
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase-activated deoxyribonuclease Synonym: CAD,CPAN,DFF40,caspase-activated nuclease Accession: P00618
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.CAD
member entity reference: DNA fragmentation factor subunit beta
member entity reference: DFFB isoform 3
member entity reference: DNAation factor-related protein 4
member entity reference: DNA fragmentation factor, beta polypeptide (caspase-activated DNase)

uniprot P08574 269
type: UnificationXref
id: P08574
db: uniprot

ICAD
type: Protein
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR23322:SF56
type: RelationshipXref
id: PTHR23322:SF56
db: PANTHER Family
relationship type: By Homology

Lamin B1
type: ProteinReference
xref: uniprot F1Q5F3 218
xref: PTHR45721:SF3
organism: Danio rerio

Protein CBR-CYC-1
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot A8X623 255
organism: Caenorhabditis briggsae

uniprot P97864 101
type: UnificationXref
id: P97864
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: uniprot P17325 94
xref: PTHR11462:SF8
organism: Rattus norvegicus

Caspase 10
type: ProteinReference
xref: PTHR10454:SF26
xref: uniprot A0A2I3RFE8 45
organism: Pan troglodytes

uniprot Q8C3Q9 14
type: UnificationXref
id: Q8C3Q9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45721:SF11
xref: uniprot W4XFQ5 239
organism: Strongylocentrotus purpuratus

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot I0FRT6 162
organism: Macaca mulatta

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 3

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MXH6 159
organism: Bos taurus

mitochondrion
type: CellularLocationVocabulary
xref: GO GO:0005739 2

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot O35099 165
organism: Mus musculus

Caspase7
type: ProteinReference
xref: P00595
standard name: Caspase 7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase 7 Synonym: Casp 7,MCH3 Accession: P00595
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase7
member entity reference: Uncharacterized protein
member entity reference: Caspase 7
member entity reference: Caspase-7
member entity reference: CASP7 isoform 1
member entity reference: Caspase 7, isoform CRA_c

PTHR11977:SF78
type: RelationshipXref
id: PTHR11977:SF78
db: PANTHER Family
relationship type: By Homology

Pro-Caspase8
type: Protein
entity reference: Pro-Caspase8
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Poly [ADP-ribose] polymerase 1
type: ProteinReference
xref: uniprot P27008 70
xref: PTHR10459:SF80
organism: Rattus norvegicus

uniprot Q14790 29
type: UnificationXref
id: Q14790
db: uniprot

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_Caspase10-RIGHT__?-_Caspase10-_r61
controller: Complex (FasL/Fas/ FasL/Fas/ FADD/DAXX/ FAF1)

uniprot O61444 122
type: UnificationXref
id: O61444
db: uniprot

Complex (ICAD/CAD)
type: Complex
component stoichiometry: CAD s9 sa6 STOICHIOMETRY ID COMPLEX
component stoichiometry: ICAD s5 sa5 STOICHIOMETRY ID COMPLEX
component: CAD
component: ICAD
feature: COMPLEX BINDING FEATURE s58 a79 302
feature: COMPLEX BINDING FEATURE s58 a79 304
cellular location: mitochondrion

Gelsolin
type: ProteinReference
xref: PTHR11977:SF29
xref: uniprot O93510 136
organism: Gallus gallus

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: uniprot P35875 71
xref: PTHR10459:SF80
organism: Drosophila melanogaster

Poly [ADP-ribose] polymerase 2-A
type: ProteinReference
xref: uniprot Q5Z8Q9 78
xref: PTHR10459:SF60
organism: Oryza sativa

GO GO:0005634 4
type: UnificationXref
id: GO:0005634
db: GO

uniprot F1MD58 34
type: UnificationXref
id: F1MD58
db: uniprot

uniprot F1NXP6 19
type: UnificationXref
id: F1NXP6
db: uniprot

ncbitaxon 7739 214
type: UnificationXref
id: 7739
db: ncbitaxon

Lamin-B2
type: ProteinReference
xref: PTHR45721:SF2
xref: uniprot Q03252 234
organism: Homo sapiens

uniprot W4XFQ5 239
type: UnificationXref
id: W4XFQ5
db: uniprot

uniprot F7C587 23
type: UnificationXref
id: F7C587
db: uniprot

Caspase9
type: Protein
entity reference: Caspase9
feature: COMPLEX PARTICIPANT BINDING FEATURE s10 sa7 299
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR10459:SF66
type: RelationshipXref
id: PTHR10459:SF66
db: PANTHER Family
relationship type: By Homology

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_Caspase7-RIGHT__?-_Caspase7-_r62
controller: Caspase10

PARP
type: ProteinReference
xref: P00600
standard name: Poly(ADP-ribose) polymerase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.PARP
comment: ENTITY_REFERENCE_NOTES=Long Name: Poly(ADP-ribose) polymerase Synonym: ADP-ribosyl transferase,ADPRT,PARP Accession: P00600
member entity reference: AGAP003230-PA
member entity reference: Protein mono-ADP-ribosyltransferase PARP3
member entity reference: Poly [ADP-ribose] polymerase
member entity reference: Protein mono-ADP-ribosyltransferase PARP4
member entity reference: Poly [ADP-ribose] polymerase 1
member entity reference: Protein ADP-ribosyltransferase PARP3
member entity reference: Poly [ADP-ribose] polymerase 2
member entity reference: Poly [ADP-ribose] polymerase 2-A

PTHR10459:SF60
type: RelationshipXref
id: PTHR10459:SF60
db: PANTHER Family
relationship type: By Homology

PTHR10454:SF216
type: RelationshipXref
id: PTHR10454:SF216
db: PANTHER Family
relationship type: By Homology

Tumor necrosis factor ligand superfamily member 6
type: ProteinReference
xref: PTHR11471:SF33
xref: uniprot P63307 245
organism: Macaca mulatta

FasL
type: Complex
component stoichiometry: FasL s17 sa13 STOICHIOMETRY ID COMPLEX
component: FasL
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa13 289
cellular location: cytoplasm

FasL
type: Complex
component stoichiometry: FasL s1 sa1 STOICHIOMETRY ID COMPLEX
component: FasL
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 309
cellular location: cytoplasm

FasL
type: Complex
component stoichiometry: FasL s12 sa9 STOICHIOMETRY ID COMPLEX
component: FasL
feature: COMPLEX PARTICIPANT BINDING FEATURE s12 sa9 311
cellular location: cytoplasm

Lamin B1
type: ProteinReference
xref: uniprot F7EGF8 223
xref: PTHR45721:SF3
organism: Xenopus tropicalis

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 268

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 43

uniprot P14733 228
type: UnificationXref
id: P14733
db: uniprot

uniprot O76075 251
type: UnificationXref
id: O76075
db: uniprot

PTHR22845:SF5
type: RelationshipXref
id: PTHR22845:SF5
db: PANTHER Family
relationship type: By Homology

uniprot P31750 166
type: UnificationXref
id: P31750
db: uniprot

DAXX
type: Protein
entity reference: DAXX
feature: ACTIVE 31
feature: COMPLEX PARTICIPANT BINDING FEATURE s24 sa18 295
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6RYL1 90
type: UnificationXref
id: F6RYL1
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11977:SF29
xref: uniprot F7HP21 132
organism: Macaca mulatta

…
type: Stoichiometry
physical entity: FasL
stoichiometric coefficient: 4.0

uniprot F6Z879 120
type: UnificationXref
id: F6Z879
db: uniprot

uniprot O15519 26
type: UnificationXref
id: O15519
db: uniprot

Lamin-1
type: ProteinReference
xref: uniprot Q21443 236
xref: PTHR45721:SF11
organism: Caenorhabditis elegans

PTHR10454:SF206
type: RelationshipXref
id: PTHR10454:SF206
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR45721:SF11
xref: uniprot C3ZXL7 213
organism: Branchiostoma floridae

PTHR10454:SF209
type: RelationshipXref
id: PTHR10454:SF209
db: PANTHER Family
relationship type: By Homology

uniprot Q8MKI5 53
type: UnificationXref
id: Q8MKI5
db: uniprot

Cytochrome c1 1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9LK29 282
organism: Arabidopsis thaliana

ncbitaxon 367110 83
type: UnificationXref
id: 367110
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r14 344
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

Lamin A
type: ProteinReference
xref: PTHR45721:SF5
xref: uniprot A0A2R8QPG3 206
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r14 343
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

uniprot Q942X6 276
type: UnificationXref
id: Q942X6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 174
xref: PTHR24055:SF162
organism: Gallus gallus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8X1S0 179
xref: PTHR24055:SF341
organism: Caenorhabditis briggsae

uniprot A0A3Q1LNG7 208
type: UnificationXref
id: A0A3Q1LNG7
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Gelsolin-RIGHT__Gelsolin-_r64
controller: Caspase3

uniprot A0A1D5QK27 5
type: UnificationXref
id: A0A1D5QK27
db: uniprot

uniprot Q99683 172
type: UnificationXref
id: Q99683
db: uniprot

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot P07143 267
organism: Saccharomyces cerevisiae

Caspase3
type: ProteinReference
xref: P00599
standard name: Caspase 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase3
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase 3 Synonym: CPP32,Casp3,PARP cleavage protease,apopain Accession: P00599
member entity reference: Caspase-3
member entity reference: Uncharacterized protein
member entity reference: Caspase 3, apoptosis-related cysteine peptidase a

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot P07142 266
organism: Neurospora crassa

uniprot A4IHY3 210
type: UnificationXref
id: A4IHY3
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q61831 200
xref: PTHR24055:SF162
organism: Mus musculus

JNK s8 a36 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

c-Jun
type: Protein
entity reference: c-Jun
feature: ACTIVE 31
feature: c Jun s29 a37 rs1
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot Q9JHX4 30
type: UnificationXref
id: Q9JHX4
db: uniprot

PARTICIPANT STOICHIOMETRY r44 352
type: Stoichiometry
physical entity: a62_degraded
stoichiometric coefficient: 1.0

Protein CBR-LMN-1
type: ProteinReference
xref: uniprot A8XF91 211
xref: PTHR45721:SF11
organism: Caenorhabditis briggsae

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1P630 181
xref: PTHR24055:SF172
organism: Canis lupus familiaris

uniprot A5D7R0 150
type: UnificationXref
id: A5D7R0
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 40

ncbitaxon 7165 81
type: UnificationXref
id: 7165
db: ncbitaxon

Lamin-B1
type: ProteinReference
xref: uniprot P20700 229
xref: PTHR45721:SF3
organism: Homo sapiens

FasL s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FasL
stoichiometric coefficient: 2.0

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot P70677 52
organism: Mus musculus

uniprot F7EGF8 223
type: UnificationXref
id: F7EGF8
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Fas-RIGHT__Complex__Fas_Fas_-_r6
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 345
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 346
left: Fas
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Fas/Fas)

…
type: Stoichiometry
physical entity: Fas
stoichiometric coefficient: 4.0

uniprot P55210 37
type: UnificationXref
id: P55210
db: uniprot

uniprot F7HFY2 48
type: UnificationXref
id: F7HFY2
db: uniprot

uniprot P47809 124
type: UnificationXref
id: P47809
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF222
xref: uniprot H2R0G7 192
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r44 351
type: Stoichiometry
physical entity: ICAD
stoichiometric coefficient: 1.0

DAXX s24 sa18 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: DAXX
stoichiometric coefficient: 1.0

uniprot K7C230 66
type: UnificationXref
id: K7C230
db: uniprot

Fas s3 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fas
stoichiometric coefficient: 2.0

uniprot F7GN93 190
type: UnificationXref
id: F7GN93
db: uniprot

Poly [ADP-ribose] polymerase 2
type: ProteinReference
xref: PTHR10459:SF60
xref: uniprot O88554 67
organism: Mus musculus

uniprot P70677 52
type: UnificationXref
id: P70677
db: uniprot

Caspase 7, isoform CRA_c
type: ProteinReference
xref: PTHR10454:SF31
xref: uniprot O88550 36
organism: Rattus norvegicus

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P49186 195
xref: PTHR24055:SF172
organism: Rattus norvegicus

uniprot Q9JHK1 16
type: UnificationXref
id: Q9JHK1
db: uniprot

Caspase9 s10 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Caspase9
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TKL3 183
xref: PTHR24055:SF222
organism: Xenopus tropicalis

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P49187 196
xref: PTHR24055:SF162
organism: Rattus norvegicus

…
type: Stoichiometry
physical entity: Fas
stoichiometric coefficient: 4.0

FADD s23 sa17 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FADD
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 379
type: Stoichiometry
physical entity: Bid
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r56 378
type: Stoichiometry
physical entity: Bid
stoichiometric coefficient: 1.0

Caspase-7
type: ProteinReference
xref: PTHR10454:SF31
xref: uniprot P97864 101
organism: Mus musculus

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: PTHR10459:SF60
xref: uniprot Q7S7M3 82
organism: Neurospora crassa

PANTHER Pathway P00020 1
type: UnificationXref
id: P00020
db: PANTHER Pathway

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot P42574 50
organism: Homo sapiens

Gelsolin
type: Protein
entity reference: Gelsolin
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

TRUNCATION
type: RelationshipTypeVocabulary

PARTICIPANT STOICHIOMETRY r6 346
type: Stoichiometry
physical entity: Complex (Fas/Fas)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 345
type: Stoichiometry
physical entity: Fas
stoichiometric coefficient: 1.0

eco ECO:0000304 56
type: UnificationXref
id: ECO:0000304
db: eco

Adseverin
type: ProteinReference
xref: PTHR11977:SF78
xref: uniprot Q9Y6U3 148
organism: Homo sapiens

Gelsolin
type: Protein
entity reference: Gelsolin
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r64 329
type: Stoichiometry
physical entity: Gelsolin
stoichiometric coefficient: 1.0

Tumor necrosis factor ligand superfamily member 6
type: ProteinReference
xref: PTHR11471:SF33
xref: uniprot P48023 244
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r64 328
type: Stoichiometry
physical entity: Gelsolin
stoichiometric coefficient: 1.0

uniprot K7CDC2 163
type: UnificationXref
id: K7CDC2
db: uniprot

…
type: Stoichiometry
physical entity: Fas
stoichiometric coefficient: 4.0

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PARP-RIGHT__PARP-_r65
controller: Caspase6

Uncharacterized protein
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot F7DMP6 261
organism: Macaca mulatta

Os01g0935700 protein
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q942X6 276
organism: Oryza sativa

Tumor necrosis factor receptor superfamily member 6
type: ProteinReference
xref: PTHR46874:SF1
xref: uniprot Q9BDP2 154
organism: Macaca mulatta

uniprot Q68FP1 145
type: UnificationXref
id: Q68FP1
db: uniprot

uniprot K7CFQ9 164
type: UnificationXref
id: K7CFQ9
db: uniprot

Caspase 6
type: ProteinReference
xref: PTHR10454:SF206
xref: uniprot F6R1R1 39
organism: Xenopus tropicalis

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

uniprot P35875 71
type: UnificationXref
id: P35875
db: uniprot

ATP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Uncharacterized protein
type: ProteinReference
xref: uniprot F6V6C6 220
xref: PTHR45721:SF5
organism: Monodelphis domestica

FAS-associated factor 1
type: ProteinReference
xref: PTHR23322:SF56
xref: uniprot P54731 111
organism: Mus musculus

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P31750 166
organism: Mus musculus

uniprot A0A2I3TJU8 9
type: UnificationXref
id: A0A2I3TJU8
db: uniprot

Bos taurus
type: BioSource
xref: ncbitaxon 9913 35

Cytochrome b/c1
type: ProteinReference
xref: uniprot P51131 270
xref: PTHR19271:SF16
organism: Bradyrhizobium diazoefficiens

Fas
type: Protein
entity reference: Fas

uniprot Q9N4H4 85
type: UnificationXref
id: Q9N4H4
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 188

Caspase 7
type: ProteinReference
xref: uniprot F1MD58 34
xref: PTHR10454:SF31
organism: Bos taurus

PTHR48013:SF20
type: RelationshipXref
id: PTHR48013:SF20
db: PANTHER Family
relationship type: By Homology

uniprot A8X623 255
type: UnificationXref
id: A8X623
db: uniprot

Pro-Caspase9
type: ProteinReference
xref: P00603
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase9 Synonym: APAF3,Apoptotic protease activating factor 3,CASP9 Accession: P00603
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase9
member entity reference: CASP9 isoform 4
member entity reference: Uncharacterized protein
member entity reference: Caspase-9
member entity reference: Caspase 9, isoform CRA_a

uniprot K7BHU1 65
type: UnificationXref
id: K7BHU1
db: uniprot

uniprot Q63199 153
type: UnificationXref
id: Q63199
db: uniprot

Gelsolin-like protein 1
type: ProteinReference
xref: uniprot Q21253 142
xref: PTHR11977:SF55
organism: Caenorhabditis elegans

Caspase-3
type: ProteinReference
xref: uniprot Q5IS54 104
organism: Pan troglodytes

uniprot E2R413 128
type: UnificationXref
id: E2R413
db: uniprot

uniprot Q61831 200
type: UnificationXref
id: Q61831
db: uniprot

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 257

MAP2K4 protein
type: ProteinReference
xref: uniprot A5PJP8 117
xref: PTHR48013:SF15
organism: Bos taurus

Pro-Caspase8
type: ProteinReference
xref: P00604
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase8 Synonym: Casp8,FLICE,MACH,MCH5,Mort1-associated ced3 homolog Accession: P00604
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase8
member entity reference: Uncharacterized protein
member entity reference: Caspase-8
member entity reference: CASP8 isoform 11
member entity reference: CASP8 and FADD-like apoptosis regulator
member entity reference: Caspase 8, apoptosis-related cysteine peptidase

uniprot O93510 136
type: UnificationXref
id: O93510
db: uniprot

uniprot A0A2J8L5H9 126
type: UnificationXref
id: A0A2J8L5H9
db: uniprot

uniprot F6V6C6 220
type: UnificationXref
id: F6V6C6
db: uniprot

uniprot P07143 267
type: UnificationXref
id: P07143
db: uniprot

Prelamin-A/C isoform 1
type: ProteinReference
xref: uniprot A0A1D5QQZ2 205
xref: PTHR45721:SF5
organism: Macaca mulatta

Complex (FasL/Fas/ FasL/Fas/ FADD/DAXX/ FAF1)
type: Complex
component stoichiometry: DAXX s24 sa18 STOICHIOMETRY ID COMPLEX
component stoichiometry: FAF1 s30 sa19 STOICHIOMETRY ID COMPLEX
component stoichiometry: FADD s23 sa17 STOICHIOMETRY ID COMPLEX
component: FADD
component: FAF1
component: FasL
component: Fas
component: DAXX
feature: COMPLEX BINDING FEATURE s102 a121 288
feature: COMPLEX BINDING FEATURE s102 a121 292
feature: COMPLEX BINDING FEATURE s102 a121 290
feature: COMPLEX BINDING FEATURE s102 a121 294
feature: COMPLEX BINDING FEATURE s102 a121 296
cellular location: cytoplasm

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 54

uniprot F7HP21 132
type: UnificationXref
id: F7HP21
db: uniprot

Protein mono-ADP-ribosyltransferase PARP4
type: ProteinReference
xref: PTHR46530:SF1
xref: uniprot Q9UKK3 87
organism: Homo sapiens

RAC serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q8INB9 170
organism: Drosophila melanogaster

uniprot O77627 91
type: UnificationXref
id: O77627
db: uniprot

uniprot P55213 51
type: UnificationXref
id: P55213
db: uniprot

uniprot P21619 230
type: UnificationXref
id: P21619
db: uniprot

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 20

PTHR11471:SF33
type: RelationshipXref
id: PTHR11471:SF33
db: PANTHER Family
relationship type: By Homology

uniprot Q17941 168
type: UnificationXref
id: Q17941
db: uniprot

ncbitaxon 9615 54
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot P25446 152
type: UnificationXref
id: P25446
db: uniprot

uniprot F6T8Z7 130
type: UnificationXref
id: F6T8Z7
db: uniprot

uniprot O08738 102
type: UnificationXref
id: O08738
db: uniprot

uniprot P42574 50
type: UnificationXref
id: P42574
db: uniprot

uniprot A0A0R4IQ11 125
type: UnificationXref
id: A0A0R4IQ11
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR23322:SF56
xref: uniprot F7FWS4 109
organism: Monodelphis domestica

uniprot E9PU64 129
type: UnificationXref
id: E9PU64
db: uniprot

Gelsolin
type: ProteinReference
xref: PTHR11977:SF29
xref: uniprot F6Y3P9 131
organism: Canis lupus familiaris

uniprot Q91Y86 202
type: UnificationXref
id: Q91Y86
db: uniprot

DAXX
type: Protein
entity reference: DAXX
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Caspase-3
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot Q8MKI5 53
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r65 326
type: Stoichiometry
physical entity: PARP
stoichiometric coefficient: 1.0

uniprot I0FPK1 97
type: UnificationXref
id: I0FPK1
db: uniprot

PARTICIPANT STOICHIOMETRY r65 327
type: Stoichiometry
physical entity: PARP
stoichiometric coefficient: 1.0

uniprot Q5U2U3 77
type: UnificationXref
id: Q5U2U3
db: uniprot

ncbitaxon 9258 188
type: UnificationXref
id: 9258
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PARP-RIGHT__PARP-_r65
controller: Caspase3

Complex (Fas/Fas)
type: Complex
component: Fas
feature: COMPLEX BINDING FEATURE s18 a31 306
cellular location: cytoplasm

Caspase8
type: ProteinReference
xref: P00594
standard name: Caspase 8
comment: ENTITY_REFERENCE_NOTES=Long Name: Caspase 8 Synonym: Casp8,FLICE,MACH,MCH5,Mort1-associated ced3 homolog Accession: P00594
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase8
member entity reference: Uncharacterized protein
member entity reference: Caspase-8
member entity reference: CASP8 isoform 11
member entity reference: CASP8 and FADD-like apoptosis regulator
member entity reference: Caspase 8, apoptosis-related cysteine peptidase

uniprot P92208 199
type: UnificationXref
id: P92208
db: uniprot

uniprot Q18853 273
type: UnificationXref
id: Q18853
db: uniprot

P00612
type: UnificationXref
id: P00612
db: PANTHER Pathway Component

P00611
type: UnificationXref
id: P00611
db: PANTHER Pathway Component

P00610
type: UnificationXref
id: P00610
db: PANTHER Pathway Component

uniprot Q09525 72
type: UnificationXref
id: Q09525
db: uniprot

P00616
type: UnificationXref
id: P00616
db: PANTHER Pathway Component

P00615
type: UnificationXref
id: P00615
db: PANTHER Pathway Component

P00614
type: UnificationXref
id: P00614
db: PANTHER Pathway Component

Lamin-B1
type: ProteinReference
xref: PTHR45721:SF3
xref: uniprot P70615 233
organism: Rattus norvegicus

uniprot F1PMN2 182
type: UnificationXref
id: F1PMN2
db: uniprot

P00618
type: UnificationXref
id: P00618
db: PANTHER Pathway Component

P00617
type: UnificationXref
id: P00617
db: PANTHER Pathway Component

Macrophage-capping protein
type: ProteinReference
xref: uniprot P40121 140
xref: PTHR11977:SF29
organism: Homo sapiens

Jun proto-oncogene
type: ProteinReference
xref: PTHR11462:SF8
xref: uniprot F6RYL1 90
organism: Xenopus tropicalis

AT03047p
type: ProteinReference
xref: PTHR10454:SF216
xref: uniprot Q9VET9 42
organism: Drosophila melanogaster

Fas
type: Protein
entity reference: Fas

CAD
type: Protein
entity reference: CAD
feature: COMPLEX PARTICIPANT BINDING FEATURE s9 sa6 305
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

uniprot P40121 140
type: UnificationXref
id: P40121
db: uniprot

uniprot P55212 103
type: UnificationXref
id: P55212
db: uniprot

Death domain-associated protein 6
type: ProteinReference
xref: PTHR12766:SF7
xref: uniprot Q8VIB2 99
organism: Rattus norvegicus

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: uniprot P47196 167
organism: Rattus norvegicus

P00601
type: UnificationXref
id: P00601
db: PANTHER Pathway Component

P00600
type: UnificationXref
id: P00600
db: PANTHER Pathway Component

P00603
type: UnificationXref
id: P00603
db: PANTHER Pathway Component

P00602
type: UnificationXref
id: P00602
db: PANTHER Pathway Component

P00605
type: UnificationXref
id: P00605
db: PANTHER Pathway Component

P00604
type: UnificationXref
id: P00604
db: PANTHER Pathway Component

P00607
type: UnificationXref
id: P00607
db: PANTHER Pathway Component

P00606
type: UnificationXref
id: P00606
db: PANTHER Pathway Component

P00609
type: UnificationXref
id: P00609
db: PANTHER Pathway Component

P00608
type: UnificationXref
id: P00608
db: PANTHER Pathway Component

Fas (TNFRSF6)-associated factor 1
type: ProteinReference
xref: PTHR23322:SF56
xref: uniprot B0UXY9 107
organism: Danio rerio

STATE_TRANSITION_LEFT__c_Jun-_ATP-RIGHT__ADP-_c_Jun-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 348
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 350
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 349
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 347
left: ATP
left: c-Jun
interaction type: STATE_TRANSITION
right: c-Jun
right: ADP

Protein ADP-ribosyltransferase PARP3
type: ProteinReference
xref: uniprot Q9FK91 84
organism: Arabidopsis thaliana

Death domain-associated protein 6
type: ProteinReference
xref: uniprot O35613 98
xref: PTHR12766:SF7
organism: Mus musculus

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 79

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 281

uniprot P54731 111
type: UnificationXref
id: P54731
db: uniprot

uniprot F7FWS4 109
type: UnificationXref
id: F7FWS4
db: uniprot

Caspase 6
type: ProteinReference
xref: PTHR10454:SF206
xref: uniprot F1NEL6 38
organism: Gallus gallus

uniprot P45984 194
type: UnificationXref
id: P45984
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F6Z879 120
organism: Monodelphis domestica

CAD
type: Protein
entity reference: CAD
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

uniprot P24452 139
type: UnificationXref
id: P24452
db: uniprot

uniprot C3ZXL7 213
type: UnificationXref
id: C3ZXL7
db: uniprot

uniprot A0A2R8QPG3 206
type: UnificationXref
id: A0A2R8QPG3
db: uniprot

uniprot Q03252 234
type: UnificationXref
id: Q03252
db: uniprot

CASP8 isoform 11
type: ProteinReference
xref: uniprot H2QJ86 25
xref: PTHR10454:SF162
organism: Pan troglodytes

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 81

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A2I3RZ31 175
xref: PTHR24055:SF162
organism: Pan troglodytes

P00622
type: UnificationXref
id: P00622
db: PANTHER Pathway Component

P00620
type: UnificationXref
id: P00620
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r63 330
type: Stoichiometry
physical entity: Apaf1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 332
type: Stoichiometry
physical entity: Complex (Caspase9/Apaf1)
stoichiometric coefficient: 1.0

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5QAU9 116
xref: PTHR48013:SF15
organism: Macaca mulatta

uniprot A8XF91 211
type: UnificationXref
id: A8XF91
db: uniprot

PARTICIPANT STOICHIOMETRY r63 331
type: Stoichiometry
physical entity: Pro-Caspase9
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r63 333
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

FAS-associated death domain protein
type: ProteinReference
xref: uniprot Q13158 285
xref: PTHR15077:SF9
organism: Homo sapiens

uniprot P63307 245
type: UnificationXref
id: P63307
db: uniprot

uniprot F1MXH6 159
type: UnificationXref
id: F1MXH6
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q91Y86 202
xref: PTHR24055:SF222
organism: Mus musculus

uniprot F7B5L8 187
type: UnificationXref
id: F7B5L8
db: uniprot

ncbitaxon 5664 275
type: UnificationXref
id: 5664
db: ncbitaxon

uniprot Q9DGD9 203
type: UnificationXref
id: Q9DGD9
db: uniprot

Pro-Caspase10
type: ProteinReference
xref: P00598
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase10 Synonym: Casp10,FLICE2,MCH4 Accession: P00598
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase10
member entity reference: Caspase-10
member entity reference: Caspase 10

FasL
type: Protein
entity reference: FasL
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

FAS-associated death domain protein
type: ProteinReference
xref: uniprot H2Q4B6 284
xref: PTHR15077:SF9
organism: Pan troglodytes

TRUNCATION_LEFT__Apaf1-_Pro_Caspase9-RIGHT__Complex__Caspase9_Apaf1_-_?-_r63
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 330
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 333
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 332
participant stoichiometry: PARTICIPANT STOICHIOMETRY r63 331
left: Pro-Caspase9
left: Apaf1
interaction type: TRUNCATION
right: Complex (Caspase9/Apaf1)
right: ?

uniprot O35099 165
type: UnificationXref
id: O35099
db: uniprot

Caspase-6
type: ProteinReference
xref: PTHR10454:SF206
xref: uniprot O08738 102
organism: Mus musculus

uniprot H2QWV8 262
type: UnificationXref
id: H2QWV8
db: uniprot

Transcription factor AP-1
type: ProteinReference
xref: uniprot P05412 92
xref: PTHR11462:SF8
organism: Homo sapiens

uniprot A4FV00 178
type: UnificationXref
id: A4FV00
db: uniprot

Gene transcription
type: Pathway

Lamin B2
type: ProteinReference
xref: uniprot D3ZLC1 215
xref: PTHR45721:SF2
organism: Rattus norvegicus

Gelsolin
type: ProteinReference
xref: PTHR11977:SF29
xref: uniprot P13020 138
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r10 363
type: Stoichiometry
physical entity: ASK1
stoichiometric coefficient: 1.0

Apaf1 s11 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Apaf1
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 362
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r10 361
type: Stoichiometry
physical entity: ASK1
stoichiometric coefficient: 1.0

…
type: Stoichiometry
physical entity: FasL
stoichiometric coefficient: 4.0

DISSOCIATION_LEFT__Complex__ICAD_CAD_-RIGHT__ICAD-_CAD-_r41
type: ComplexAssembly
spontaneous: false
conversion direction: LEFT_TO_RIGHT
xref: DISSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 365
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 367
participant stoichiometry: PARTICIPANT STOICHIOMETRY r41 366
left: Complex (ICAD/CAD)
interaction type: DISSOCIATION
right: ICAD
right: CAD

PARTICIPANT STOICHIOMETRY r10 364
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot Q5Z8Q9 78
type: UnificationXref
id: Q5Z8Q9
db: uniprot

Caspase 8, apoptosis-related cysteine peptidase
type: ProteinReference
xref: PTHR10454:SF209
xref: uniprot F1QLH0 21
organism: Danio rerio

uniprot P25445 151
type: UnificationXref
id: P25445
db: uniprot

uniprot F6TKL3 183
type: UnificationXref
id: F6TKL3
db: uniprot

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1PMN2 182
xref: PTHR24055:SF162
organism: Canis lupus familiaris

CATALYSIS
type: Catalysis
controlled: DISSOCIATION_LEFT__Complex__ICAD_CAD_-RIGHT__ICAD-_CAD-_r41
controller: Caspase3

ncbitaxon 8364 40
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot Q9BDP2 154
type: UnificationXref
id: Q9BDP2
db: uniprot

PTHR11462:SF8
type: RelationshipXref
id: PTHR11462:SF8
db: PANTHER Family
relationship type: By Homology

uniprot H2QMQ4 64
type: UnificationXref
id: H2QMQ4
db: uniprot

uniprot Q9Y6U3 148
type: UnificationXref
id: Q9Y6U3
db: uniprot

Lamin A/C
type: ProteinReference
xref: uniprot F6YQA9 222
xref: PTHR45721:SF5
organism: Xenopus tropicalis

ncbitaxon 6945 257
type: UnificationXref
id: 6945
db: ncbitaxon

Caspase 9, isoform CRA_a
type: ProteinReference
xref: uniprot Q9JHK1 16
xref: PTHR10454:SF157
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r37 322
type: Stoichiometry
physical entity: CAD
stoichiometric coefficient: 1.0

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 264

uniprot O35613 98
type: UnificationXref
id: O35613
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR45721:SF3
xref: uniprot A0A3Q1LNG7 208
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r37 323
type: Stoichiometry
physical entity: CAD
stoichiometric coefficient: 1.0

FAF1
type: Protein
entity reference: FAF1
feature: ACTIVE 31
feature: COMPLEX PARTICIPANT BINDING FEATURE s30 sa19 297
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot B7P8B3 256
type: UnificationXref
id: B7P8B3
db: uniprot

Fas
type: ProteinReference
xref: P00612
comment: ENTITY_REFERENCE_NOTES=Long Name: Fas Synonym: Synonym not specified Accession: P00612
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.RECEPTOR.Fas
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Tumor necrosis factor receptor superfamily member 6
member entity reference: FAS protein
member entity reference: Fas cell surface death receptor

Pro-Caspase3
type: ProteinReference
xref: P00608
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase3
comment: ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase3 Synonym: CPP32,Casp3,PARP cleavage protease,apopain Accession: P00608
member entity reference: Caspase-3
member entity reference: Uncharacterized protein
member entity reference: Caspase 3, apoptosis-related cysteine peptidase a

uniprot Q11207 74
type: UnificationXref
id: Q11207
db: uniprot

DISSOCIATION
type: InteractionVocabulary

FADD
type: Protein
entity reference: FADD
feature: COMPLEX PARTICIPANT BINDING FEATURE s23 sa17 293
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 9544 6
type: UnificationXref
id: 9544
db: ncbitaxon

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot Q99683 172
organism: Homo sapiens

DNA fragmentation factor subunit beta
type: ProteinReference
xref: PTHR13067:SF2
xref: uniprot O76075 251
organism: Homo sapiens

MKK4
type: Protein
entity reference: MKK4
feature: ACTIVE 31
feature: MKK4 s27 a7 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 12

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 204
xref: PTHR24055:SF172
organism: Mus musculus

PTHR24055:SF341
type: RelationshipXref
id: PTHR24055:SF341
db: PANTHER Family
relationship type: By Homology

Scinderin
type: ProteinReference
xref: PTHR11977:SF78
xref: uniprot E9PU64 129
organism: Rattus norvegicus

uniprot A2VE17 127
type: UnificationXref
id: A2VE17
db: uniprot

Complex (Caspase9/Apaf1)
type: Complex
component stoichiometry: Apaf1 s11 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: Caspase9 s10 sa7 STOICHIOMETRY ID COMPLEX
component: Caspase9
component: Apaf1
feature: COMPLEX BINDING FEATURE s67 a91 300
feature: ACTIVE 31
feature: COMPLEX BINDING FEATURE s67 a91 298
cellular location: cytoplasm

PTHR10454:SF26
type: RelationshipXref
id: PTHR10454:SF26
db: PANTHER Family
relationship type: By Homology

uniprot O54788 250
type: UnificationXref
id: O54788
db: uniprot

uniprot E2REM0 260
type: UnificationXref
id: E2REM0
db: uniprot

AT13706p
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q9VAM8 283
organism: Drosophila melanogaster

Uncharacterized protein
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot F7HFY2 48
organism: Macaca mulatta

PTHR10454:SF31
type: RelationshipXref
id: PTHR10454:SF31
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Q273 219
xref: PTHR45721:SF3
organism: Macaca mulatta

Lamin-C
type: ProteinReference
xref: PTHR45721:SF11
xref: uniprot Q03427 235
organism: Drosophila melanogaster

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Apaf1-_Pro_Caspase9-RIGHT__Complex__Caspase9_Apaf1_-_?-_r63
controller: CytochromeC

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6Y4G8 185
xref: PTHR24055:SF222
organism: Canis lupus familiaris

CYC1 isoform 2
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot H2QWV8 262
organism: Pan troglodytes

Caspase3
type: Protein
entity reference: Caspase3
feature: ACTIVE 31
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 240

Caspase-10
type: ProteinReference
xref: PTHR10454:SF26
xref: uniprot Q92851 46
organism: Homo sapiens

AGAP003230-PA
type: ProteinReference
xref: uniprot Q7QBC7 80
organism: Anopheles gambiae

MAP3K5 isoform 1
type: ProteinReference
xref: uniprot K7CFQ9 164
organism: Pan troglodytes

DNAation factor-related protein 4
type: ProteinReference
xref: PTHR13067:SF2
xref: uniprot Q9V3H0 254
organism: Drosophila melanogaster

uniprot P02545 226
type: UnificationXref
id: P02545
db: uniprot

DNA fragmentation factor subunit beta
type: ProteinReference
xref: PTHR13067:SF2
xref: uniprot Q99N34 253
organism: Rattus norvegicus

uniprot A0A1D5QAU9 116
type: UnificationXref
id: A0A1D5QAU9
db: uniprot

uniprot F1NAM2 217
type: UnificationXref
id: F1NAM2
db: uniprot

DNA
type: DnaRegion
cellular location: nucleus
comment: SPECIES_TYPE=GENE

uniprot A0A3Q2TY19 177
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

uniprot O35732 27
type: UnificationXref
id: O35732
db: uniprot

uniprot O88550 36
type: UnificationXref
id: O88550
db: uniprot

ASK1 s6 a34 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

TRUNCATION_LEFT__Pro_Caspase8-RIGHT__?-_Caspase8-_r60
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: TRUNCATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 341
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 340
participant stoichiometry: PARTICIPANT STOICHIOMETRY r60 342
left: Pro-Caspase8
interaction type: TRUNCATION
right: Caspase8
right: ?

uniprot F7CYE3 189
type: UnificationXref
id: F7CYE3
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Nuclear_Lamin-RIGHT__Nuclear_Lamin-_r66
controller: Caspase6

Caspar, isoform A
type: ProteinReference
xref: uniprot Q7JUP3 113
organism: Drosophila melanogaster

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

LMNB1 isoform 1
type: ProteinReference
xref: PTHR45721:SF3
xref: uniprot H2QRE7 225
organism: Pan troglodytes

uniprot P45985 123
type: UnificationXref
id: P45985
db: uniprot

Cytochrome c1, putative
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot B7P8B3 256
organism: Ixodes scapularis

DAXX isoform 1
type: ProteinReference
xref: PTHR12766:SF7
xref: uniprot A0A2J8NYK5 96
organism: Pan troglodytes

ncbitaxon 7668 240
type: UnificationXref
id: 7668
db: ncbitaxon

Nuclear Lamin
type: ProteinReference
xref: P00616
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Nuclear Lamin Synonym: Synonym not specified Accession: P00616
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Nuclear Lamin
member entity reference: Lamin B2
member entity reference: Uncharacterized protein
member entity reference: Protein CBR-LMN-1
member entity reference: Lamin-C
member entity reference: Prelamin-A/C
member entity reference: Lamin B1
member entity reference: LMNA isoform 8
member entity reference: Lamin A/C
member entity reference: AGAP011938-PA
member entity reference: Lamin-B1
member entity reference: Lamin L3
member entity reference: Lamin A
member entity reference: LMNB1 isoform 1
member entity reference: Lamin-B2
member entity reference: Lamin B3
member entity reference: Prelamin-A/C isoform 1
member entity reference: AGAP008015-PA
member entity reference: Lamin-1
member entity reference: Lamin Dm0

Nuclear Lamin
type: Protein
entity reference: Nuclear Lamin
feature: ACTIVE 31
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

ICAD
type: Protein
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa5 303
cellular location: mitochondrion
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 39947 79
type: UnificationXref
id: 39947
db: ncbitaxon

Lamin-B2
type: ProteinReference
xref: PTHR45721:SF2
xref: uniprot P21619 230
organism: Mus musculus

a62_degraded
type: PhysicalEntity
cellular location: cytoplasm
comment: SPECIES_TYPE=DEGRADED

CAPG isoform 1
type: ProteinReference
xref: PTHR11977:SF29
xref: uniprot A0A2J8L5H9 126
organism: Pan troglodytes

Pro-Caspase7
type: ProteinReference
xref: P00605
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase7
comment: ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase7 Synonym: Casp 7,MCH3 Accession: P00605
member entity reference: Caspase-7
member entity reference: Uncharacterized protein
member entity reference: Caspase 7
member entity reference: CASP7 isoform 1
member entity reference: Caspase 7, isoform CRA_c

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

uniprot Q8UUX0 171
type: UnificationXref
id: Q8UUX0
db: uniprot

uniprot P00125 265
type: UnificationXref
id: P00125
db: uniprot

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: uniprot K7BHU1 65
xref: PTHR10459:SF60
organism: Pan troglodytes

LMNA isoform 8
type: ProteinReference
xref: PTHR45721:SF5
xref: uniprot H2Q091 224
organism: Pan troglodytes

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 259

HETERODIMER_ASSOCIATION_LEFT__Complex__Fas_Fas_-_Complex__FasL_FasL_-RIGHT__Complex__FasL_FasL__Fas_Fas_-_r51
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 319
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 321
participant stoichiometry: PARTICIPANT STOICHIOMETRY r51 320
left: Complex (FasL/FasL)
left: Complex (Fas/Fas)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (FasL/FasL/ Fas/Fas)

TAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000304 56

FasL
type: Protein
entity reference: FasL

uniprot A0A1D5RGZ3 32
type: UnificationXref
id: A0A1D5RGZ3
db: uniprot

STATE_TRANSITION_LEFT__PARP-RIGHT__PARP-_r65
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 327
participant stoichiometry: PARTICIPANT STOICHIOMETRY r65 326
left: PARP
interaction type: STATE_TRANSITION
right: PARP

uniprot F6X747 58
type: UnificationXref
id: F6X747
db: uniprot

Fas s14 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Fas
stoichiometric coefficient: 2.0

JNK
type: Protein
entity reference: JNK
feature: JNK s8 a36 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7EMW7 59
type: UnificationXref
id: F7EMW7
db: uniprot

FAF1
type: Protein
entity reference: FAF1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q9WTU6 204
type: UnificationXref
id: Q9WTU6
db: uniprot

CytochromeC
type: ProteinReference
xref: P00620
comment: ENTITY_REFERENCE_NOTES=Long Name: CytochromeC Synonym: Synonym not specified Accession: P00620
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.CytochromeC
member entity reference: Os01g0935700 protein
member entity reference: Cytochrome c1, heme protein, mitochondrial
member entity reference: Cytochrome c1
member entity reference: CYtochrome C
member entity reference: Cytochrome c1 1, heme protein, mitochondrial
member entity reference: Os05g0301700 protein
member entity reference: Cytochrome c1, putative
member entity reference: Cytochrome c1 2, heme protein, mitochondrial
member entity reference: AT13706p
member entity reference: Cytochrome b/c1
member entity reference: Uncharacterized protein
member entity reference: Probable cytochrome c1
member entity reference: CYC1 isoform 2
member entity reference: Protein CBR-CYC-1
member entity reference: Putative cytochrome c1, heme protein,mitochondrial

uniprot E2R6T4 89
type: UnificationXref
id: E2R6T4
db: uniprot

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: uniprot G3N186 61
xref: PTHR10459:SF60
organism: Bos taurus

uniprot Q9FKS5 277
type: UnificationXref
id: Q9FKS5
db: uniprot

PTHR24055:SF172
type: RelationshipXref
id: PTHR24055:SF172
db: PANTHER Family
relationship type: By Homology

Death domain-associated protein 6
type: ProteinReference
xref: PTHR12766:SF7
xref: uniprot Q9UER7 100
organism: Homo sapiens

ncbitaxon 185431 259
type: UnificationXref
id: 185431
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: TRUNCATION_LEFT__Pro_Caspase6-RIGHT__Caspase6-_?-_r57
controller: Caspase3

Nuclear Lamin
type: Protein
entity reference: Nuclear Lamin
cellular location: nucleus
comment: SPECIES_TYPE=PROTEIN

c Jun s25 a38 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Uncharacterized protein
type: ProteinReference
xref: uniprot F7C587 23
xref: PTHR10454:SF162
organism: Macaca mulatta

uniprot P05412 92
type: UnificationXref
id: P05412
db: uniprot

ncbitaxon 7955 22
type: UnificationXref
id: 7955
db: ncbitaxon

AGAP011938-PA
type: ProteinReference
xref: uniprot Q7PZJ0 238
organism: Anopheles gambiae

PTHR45721:SF11
type: RelationshipXref
id: PTHR45721:SF11
db: PANTHER Family
relationship type: By Homology

FasL s17 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FasL
stoichiometric coefficient: 2.0

uniprot K6ZGT0 249
type: UnificationXref
id: K6ZGT0
db: uniprot

Gelsolin
type: ProteinReference
xref: PTHR11977:SF29
xref: uniprot P06396 137
organism: Homo sapiens

STATE_TRANSITION
type: InteractionVocabulary

Cytochrome c1, heme protein, mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot D6XKS6 258
organism: Trypanosoma brucei

TRANSPORT
type: InteractionVocabulary

uniprot P48678 231
type: UnificationXref
id: P48678
db: uniprot

STATE_TRANSITION_LEFT__DAXX-_FADD-_Complex__FasL_FasL__Fas_Fas_-_FAF1-RIGHT__Complex__FasL_Fas__FasL_Fas__FADD_DAXX__FAF1_-_r53
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 316
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 318
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 315
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 317
participant stoichiometry: PARTICIPANT STOICHIOMETRY r53 314
left: FAF1
left: FADD
left: DAXX
left: Complex (FasL/FasL/ Fas/Fas)
interaction type: STATE_TRANSITION
right: Complex (FasL/Fas/ FasL/Fas/ FADD/DAXX/ FAF1)

uniprot O88554 67
type: UnificationXref
id: O88554
db: uniprot

PARTICIPANT STOICHIOMETRY r51 320
type: Stoichiometry
physical entity: Complex (FasL/FasL)
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0R4IKK9 173
xref: PTHR24055:SF162
organism: Danio rerio

PARTICIPANT STOICHIOMETRY r51 321
type: Stoichiometry
physical entity: Complex (FasL/FasL/ Fas/Fas)
stoichiometric coefficient: 1.0

Macrophage-capping protein
type: ProteinReference
xref: uniprot Q6AYC4 146
xref: PTHR11977:SF29
organism: Rattus norvegicus

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: PTHR10459:SF60
xref: uniprot F7GE72 60
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r51 319
type: Stoichiometry
physical entity: Complex (Fas/Fas)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 372
type: Stoichiometry
physical entity: Pro-Caspase3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 374
type: Stoichiometry
physical entity: Caspase3
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r58 373
type: Stoichiometry
physical entity: ?
stoichiometric coefficient: 1.0

uniprot Q8VIB2 99
type: UnificationXref
id: Q8VIB2
db: uniprot

PTHR45721:SF3
type: RelationshipXref
id: PTHR45721:SF3
db: PANTHER Family
relationship type: By Homology

PTHR45721:SF2
type: RelationshipXref
id: PTHR45721:SF2
db: PANTHER Family
relationship type: By Homology

uniprot P27008 70
type: UnificationXref
id: P27008
db: uniprot

PTHR45721:SF5
type: RelationshipXref
id: PTHR45721:SF5
db: PANTHER Family
relationship type: By Homology

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E2RJX4 158
organism: Canis lupus familiaris

PTHR45721:SF4
type: RelationshipXref
id: PTHR45721:SF4
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r12 353
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

Tumor necrosis factor receptor superfamily member 6
type: ProteinReference
xref: PTHR46874:SF1
xref: uniprot P25446 152
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r12 354
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

PTHR12766:SF7
type: RelationshipXref
id: PTHR12766:SF7
db: PANTHER Family
relationship type: By Homology

Jun proto-oncogene, AP-1 transcription factor subunit
type: ProteinReference
xref: uniprot E2R6T4 89
xref: PTHR11462:SF8
organism: Canis lupus familiaris

ncbitaxon 9031 20
type: UnificationXref
id: 9031
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r12 355
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

uniprot F7DGQ2 24
type: UnificationXref
id: F7DGQ2
db: uniprot

PARTICIPANT STOICHIOMETRY r12 356
type: Stoichiometry
physical entity: JNK
stoichiometric coefficient: 1.0

Tumor necrosis factor receptor superfamily member 6
type: ProteinReference
xref: uniprot P25445 151
xref: PTHR46874:SF1
organism: Homo sapiens

uniprot P08928 227
type: UnificationXref
id: P08928
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 275

?
type: Protein
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

FasL
type: Protein
entity reference: FasL

Poly [ADP-ribose] polymerase 1
type: ProteinReference
xref: uniprot Q9N4H4 85
xref: PTHR10459:SF80
organism: Caenorhabditis elegans

Poly [ADP-ribose] polymerase
type: ProteinReference
xref: uniprot F1Q2M3 57
xref: PTHR10459:SF80
organism: Canis lupus familiaris

Caspase 3, apoptosis-related cysteine peptidase a
type: ProteinReference
xref: PTHR10454:SF198
xref: uniprot B8JK21 47
organism: Danio rerio

PTHR10459:SF80
type: RelationshipXref
id: PTHR10459:SF80
db: PANTHER Family
relationship type: By Homology

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 13

uniprot P13020 138
type: UnificationXref
id: P13020
db: uniprot

uniprot F6QTM2 108
type: UnificationXref
id: F6QTM2
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7GN93 190
xref: PTHR24055:SF162
organism: Macaca mulatta

CATALYSIS
type: Catalysis
controller: Bid

Gelsolin
type: ProteinReference
xref: PTHR11977:SF29
xref: uniprot Q3SX14 143
organism: Bos taurus

PARTICIPANT STOICHIOMETRY r3 369
type: Stoichiometry
physical entity: Complex (FasL/FasL)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 368
type: Stoichiometry
physical entity: FasL
stoichiometric coefficient: 1.0

uniprot Q8INB9 170
type: UnificationXref
id: Q8INB9
db: uniprot

uniprot A0A3Q2U596 209
type: UnificationXref
id: A0A3Q2U596
db: uniprot

Lamin B1
type: ProteinReference
xref: PTHR45721:SF3
xref: uniprot F1NAM2 217
organism: Gallus gallus

Putative cytochrome c1, heme protein,mitochondrial
type: ProteinReference
xref: PTHR10266:SF3
xref: uniprot Q4QIT8 274
organism: Leishmania major

Caspase-8
type: ProteinReference
xref: PTHR10454:SF162
xref: uniprot Q9JHX4 30
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Nuclear_Lamin-RIGHT__Nuclear_Lamin-_r66
controller: Caspase3