ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.ASK1
ENTITY_REFERENCE_NOTES=Long Name: Apoptosis signal regulating kinase 1 Synonym: MAP3K5,Mitogen activated protein kinase kinase kinase 5 Accession: P00614
Tumor necrosis factor receptor superfamily member 6
Tumor necrosis factor ligand superfamily member 6
MODEL_NOTES=Panther Pathway: P00020 The Fas receptor (CD95) mediates apoptotic signaling intiated by interaction with surface expressed FasL on other cells. The Fas-FasL interaction plays an important role in the immune system, and loss of function mutations in the Fas signaling pathway can result in hyper-proliferation of cells and autoimmunity. Upon Fas-FasL interaction, the apoptotic program is mediated by recruitment of signaling adaptor molecules to the Fas receptor via a death domain. This leads to the activation of a proteolytic cascade of specific proteases termed caspases. The activated caspases cleave a variety of cellular substrates that lead to morphological changes, DNA fragmentation, and ultimately cell death. Website=http://stke.sciencemag.org/cgi/cm/stkecm;CMP_7966 Website=http://www.biocarta.com/pathfiles/h_fasPathway.asp
Non-specific serine/threonine protein kinase
ENTITY_REFERENCE_NOTES=Long Name: DAXX Synonym: Synonym not specified Accession: P00602
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.DAXX
Cytochrome c1, heme protein, mitochondrial
ENTITY_REFERENCE_NOTES=Long Name: c-Jun Synonym: Synonym not specified Accession: P00601
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.c-Jun
Mitogen-activated protein kinase kinase 4
ENTITY_REFERENCE_NOTES=Long Name: Mitogen-activated protein kinase kinase 4 Synonym: JNK-activated kinase 1,JNKK1,MAP2K4,MAPKK4,MEK4,MKK4,SAPK/ERK kinase 1,SEK1 Accession: P00610
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.MKK4
DNA fragmentation factor, beta polypeptide (caspase-activated DNase)
Protein mono-ADP-ribosyltransferase PARP3
Mitogen-activated protein kinase kinase 4A
Cytochrome c1 2, heme protein, mitochondrial
ENTITY_REFERENCE_NOTES=Long Name: Caspase6 Synonym: Casp6,MCH2 Accession: P00596
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase6
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase9
ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase6 Synonym: Casp6,MCH2 Accession: P00607
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase6
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.FAF1
ENTITY_REFERENCE_NOTES=Long Name: FAF1 Synonym: Synonym not specified Accession: P00609
Dual specificity mitogen-activated protein kinase kinase 4
ENTITY_REFERENCE_NOTES=Long Name: Fas ligand Synonym: APT1LG1,Apoptosis antigen ligand 1,FasL Accession: P00617
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.RECEPTOR.FasL
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.JNK
ENTITY_REFERENCE_NOTES=Long Name: c-Jun kinase Synonym: JNK,SAPK,Stress-activated protein kinase Accession: P00615
Death domain-associated protein 6 isoform a
Fas-associating protein with death domain
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.FADD
ENTITY_REFERENCE_NOTES=Long Name: Fas-associating protein with death domain Synonym: Synonym not specified Accession: P00622
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase10
ENTITY_REFERENCE_NOTES=Long Name: Caspase 10 Synonym: Casp10,FLICE2,MCH4 Accession: P00606
ENTITY_REFERENCE_NOTES=Long Name: Gelsolin Synonym: Synonym not specified Accession: P00611
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Gelsolin
ENTITY_REFERENCE_NOTES=Long Name: Apoptotic protease activating factor1 Synonym: APAF1,APAF3,Apoptotic protease activating factor 3,CASP9 Accession: P00597
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Apaf1
ENTITY_REFERENCE_NOTES=Long Name: Caspase-activated deoxyribonuclease Synonym: CAD,CPAN,DFF40,caspase-activated nuclease Accession: P00618
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.CAD
Mitogen-activated protein kinase kinase kinase 5
ENTITY_REFERENCE_NOTES=Long Name: Caspase 7 Synonym: Casp 7,MCH3 Accession: P00595
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase7
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.PARP
ENTITY_REFERENCE_NOTES=Long Name: Poly(ADP-ribose) polymerase Synonym: ADP-ribosyl transferase,ADPRT,PARP Accession: P00600
Cytochrome c1 1, heme protein, mitochondrial
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase3
ENTITY_REFERENCE_NOTES=Long Name: Caspase 3 Synonym: CPP32,Casp3,PARP cleavage protease,apopain Accession: P00599
RAC-alpha serine/threonine-protein kinase
ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase9 Synonym: APAF3,Apoptotic protease activating factor 3,CASP9 Accession: P00603
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase9
ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase8 Synonym: Casp8,FLICE,MACH,MCH5,Mort1-associated ced3 homolog Accession: P00604
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase8
Complex (FasL/Fas/ FasL/Fas/ FADD/DAXX/ FAF1)
Protein mono-ADP-ribosyltransferase PARP4
ENTITY_REFERENCE_NOTES=Long Name: Caspase 8 Synonym: Casp8,FLICE,MACH,MCH5,Mort1-associated ced3 homolog Accession: P00594
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Caspase8
ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase10 Synonym: Casp10,FLICE2,MCH4 Accession: P00598
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase10
Caspase 8, apoptosis-related cysteine peptidase
ENTITY_REFERENCE_NOTES=Long Name: Fas Synonym: Synonym not specified Accession: P00612
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.RECEPTOR.Fas
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase3
ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase3 Synonym: CPP32,Casp3,PARP cleavage protease,apopain Accession: P00608
ENTITY_REFERENCE_NOTES=Long Name: Nuclear Lamin Synonym: Synonym not specified Accession: P00616
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Nuclear Lamin
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.Pro-Caspase7
ENTITY_REFERENCE_NOTES=Long Name: Pro-Caspase7 Synonym: Casp 7,MCH3 Accession: P00605
ENTITY_REFERENCE_NOTES=Long Name: CytochromeC Synonym: Synonym not specified Accession: P00620
ENTITY_REFERENCE_ID_DESC=FAS signaling pathway.PROTEIN.GENERIC.CytochromeC
Jun proto-oncogene, AP-1 transcription factor subunit
Caspase 3, apoptosis-related cysteine peptidase a
Putative cytochrome c1, heme protein,mitochondrial