Serine/threonine-protein phosphatase PP1-1
type: ProteinReference
xref: uniprot P20604 494
organism: Saccharomyces cerevisiae

Rac family small GTPase 3
type: ProteinReference
xref: uniprot F6THF0 1047
xref: PTHR24072:SF301
organism: Monodelphis domestica

uniprot H2QNZ3 60
type: UnificationXref
id: H2QNZ3
db: uniprot

Fibroblast growth factor receptor
type: ProteinReference
xref: PTHR24416:SF130
xref: uniprot F7DHF8 801
organism: Monodelphis domestica

PTHR24356:SF303
type: RelationshipXref
id: PTHR24356:SF303
db: PANTHER Family
relationship type: By Homology

PTHR11486:SF67
type: RelationshipXref
id: PTHR11486:SF67
db: PANTHER Family
relationship type: By Homology

AT17867p
type: ProteinReference
xref: uniprot Q7JWS8 1084
organism: Drosophila melanogaster

ERK1-2
type: ProteinReference
xref: P00627
standard name: Extracellular signal-regulated kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.ERK1_minus_2
comment: ENTITY_REFERENCE_NOTES= Long Name: Extracellular signal-regulated kinase Synonym: MAPK,Mitogen-activated protein kinase,pp42/44 Accession: P00627
member entity reference: Mitogen-activated protein kinase 3
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 2
member entity reference: Mitogen-activated protein kinase 1
member entity reference: Mitogen-activated protein kinase KSS1
member entity reference: Mitogen-activated protein kinase mpk-1
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase (Fragment)
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase 4
member entity reference: Extracellular signal-regulated kinase 1
member entity reference: Mitogen-activated protein kinase spk1
member entity reference: Mitogen-activated protein kinase 7
member entity reference: Mitogen-activated protein kinase FUS3
member entity reference: Mitogen-activated protein kinase 6
member entity reference: Mitogen-activated protein kinase 5
member entity reference: Mitogen-activated protein kinase 10

ncbitaxon 665079 317
type: UnificationXref
id: 665079
db: ncbitaxon

uniprot O35904 910
type: UnificationXref
id: O35904
db: uniprot

FGFR1 4 s84 a46 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 2.0

14-3-3 protein theta
type: ProteinReference
xref: uniprot P27348 192
xref: PTHR18860:SF3
organism: Homo sapiens

PTHR11486:SF72
type: RelationshipXref
id: PTHR11486:SF72
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6SZ66 890
xref: PTHR10048:SF7
organism: Monodelphis domestica

uniprot F1PHV7 699
type: UnificationXref
id: F1PHV7
db: uniprot

PTHR11486:SF71
type: RelationshipXref
id: PTHR11486:SF71
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A9TXC9 425
organism: Physcomitrella patens

PANTHER Pathway P00021 1
type: UnificationXref
id: P00021
db: PANTHER Pathway

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A452DI16 988
organism: Bos taurus

PTHR24351:SF200
type: RelationshipXref
id: PTHR24351:SF200
db: PANTHER Family
relationship type: By Homology

Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform
type: ProteinReference
xref: uniprot Q8LF36 588
organism: Arabidopsis thaliana

14-3-3 protein sigma
type: ProteinReference
xref: PTHR18860:SF14
xref: uniprot O70456 191
organism: Mus musculus

uniprot E2RN01 23
type: UnificationXref
id: E2RN01
db: uniprot

Raf 1 s23 a26 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.662707240054924

uniprot O35565 70
type: UnificationXref
id: O35565
db: uniprot

uniprot Q7S7P2 577
type: UnificationXref
id: Q7S7P2
db: uniprot

ncbitaxon 6945 147
type: UnificationXref
id: 6945
db: ncbitaxon

Spry s11 a10 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot F6XT65 964
type: UnificationXref
id: F6XT65
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 71

uniprot A0A2J8QY32 875
type: UnificationXref
id: A0A2J8QY32
db: uniprot

uniprot E2RQM0 843
type: UnificationXref
id: E2RQM0
db: uniprot

uniprot Q7PMF0 930
type: UnificationXref
id: Q7PMF0
db: uniprot

uniprot E2RGU9 293
type: UnificationXref
id: E2RGU9
db: uniprot

uniprot Q92914 123
type: UnificationXref
id: Q92914
db: uniprot

uniprot D4A3T0 938
type: UnificationXref
id: D4A3T0
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot A0A2I3T7V6 10
organism: Pan troglodytes

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P28482 337
xref: PTHR24055:SF203
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
type: ProteinReference
xref: uniprot Q80W83 583
xref: PTHR10257:SF4
organism: Rattus norvegicus

Raf 1 s23 a26 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.6130914234684163

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
controller: PP2A

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PXS7 322
xref: PTHR24055:SF393
organism: Canis lupus familiaris

uniprot Q61194 927
type: UnificationXref
id: Q61194
db: uniprot

STATE_TRANSITION_LEFT__MKK4,7-RIGHT__MKK4,7-_r23
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1280
participant stoichiometry: PARTICIPANT STOICHIOMETRY r23 1281
left: MKK4,7
interaction type: STATE_TRANSITION
right: MKK4,7

uniprot Q0VD16 972
type: UnificationXref
id: Q0VD16
db: uniprot

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: uniprot Q4QGB0 976
organism: Leishmania major

PTHR11486:SF41
type: RelationshipXref
id: PTHR11486:SF41
db: PANTHER Family
relationship type: By Homology

uniprot O89101 76
type: UnificationXref
id: O89101
db: uniprot

Akt s21 a24 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot P92177 231
xref: PTHR18860:SF17
organism: Drosophila melanogaster

Probable serine/threonine protein phosphatase 2A regulatory subunit B''delta
type: ProteinReference
xref: uniprot Q9SLI8 598
organism: Arabidopsis thaliana

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: uniprot A0A2I3TN31 771
xref: PTHR21258:SF40
organism: Pan troglodytes

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot F1MBU9 886
organism: Bos taurus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
type: ProteinReference
xref: uniprot A4FV68 411
xref: PTHR10257:SF92
organism: Bos taurus

uniprot Q08DP7 527
type: UnificationXref
id: Q08DP7
db: uniprot

PTHR24072:SF301
type: RelationshipXref
id: PTHR24072:SF301
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q8NEB9 933
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF5
xref: uniprot F1P8X1 450
organism: Canis lupus familiaris

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: PTHR23113:SF168
xref: uniprot F1Q118 942
organism: Canis lupus familiaris

uniprot H2QPS2 61
type: UnificationXref
id: H2QPS2
db: uniprot

uniprot Q9Y2U5 768
type: UnificationXref
id: Q9Y2U5
db: uniprot

uniprot F6Y4G8 372
type: UnificationXref
id: F6Y4G8
db: uniprot

PTHR24072:SF300
type: RelationshipXref
id: PTHR24072:SF300
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
type: ProteinReference
xref: uniprot G5EDR3 478
xref: PTHR11871:SF0
organism: Caenorhabditis elegans

Raf 1 s23 a26 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.5581540179231173

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P27361 335
xref: PTHR24055:SF393
organism: Homo sapiens

PLCgamma
type: ProteinReference
xref: P00638
standard name: phospholipase c gamma
comment: ENTITY_REFERENCE_NOTES= Long Name: phospholipase c gamma Synonym: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma,phosphoinositide phospholipase C Accession: P00638
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.PLC_sub__gamma
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
member entity reference: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3

Protein sprouty homolog 4
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot Q9C004 308
organism: Homo sapiens

uniprot Q5Y173 307
type: UnificationXref
id: Q5Y173
db: uniprot

AGR107Cp
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q74ZU1 258
organism: Ashbya gossypii

uniprot Q9VDS9 766
type: UnificationXref
id: Q9VDS9
db: uniprot

uniprot F6Z879 828
type: UnificationXref
id: F6Z879
db: uniprot

MEKK1 5 s49 a61 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Neurospora crassa
type: BioSource
xref: ncbitaxon 367110 262

PTHR11486:SF31
type: RelationshipXref
id: PTHR11486:SF31
db: PANTHER Family
relationship type: By Homology

14-3-3 protein
type: ProteinReference
xref: uniprot C0H4V6 148
xref: PTHR18860:SF17
organism: Plasmodium falciparum

uniprot Q5ZKJ2 250
type: UnificationXref
id: Q5ZKJ2
db: uniprot

uniprot P53778 1021
type: UnificationXref
id: P53778
db: uniprot

NRAS protein
type: ProteinReference
xref: uniprot A5D7R9 688
xref: PTHR24070:SF189
organism: Bos taurus

Fibroblast growth factor receptor 4
type: ProteinReference
xref: PTHR24416:SF343
xref: uniprot Q03142 813
organism: Mus musculus

uniprot Q9LVE2 597
type: UnificationXref
id: Q9LVE2
db: uniprot

uniprot Q10664 973
type: UnificationXref
id: Q10664
db: uniprot

uniprot Q8VI02 590
type: UnificationXref
id: Q8VI02
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q01986 970
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 4 catalytic subunit 2
type: ProteinReference
xref: uniprot Q9XTT8 605
organism: Caenorhabditis elegans

INHIBITION
type: Control
xref: INHIBITION
controlled: HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-RIGHT__Complex__SOS_Grb2_-_r33
control type: INHIBITION
controller: Spry

Raf 1 s23 a26 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.8069631906872994

PTHR24356:SF347
type: RelationshipXref
id: PTHR24356:SF347
db: PANTHER Family
relationship type: By Homology

MEKK1 5 s49 a61 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PTHR11486:SF26
type: RelationshipXref
id: PTHR11486:SF26
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q8RZZ3 589
organism: Oryza sativa

PP2A
type: ProteinReference
xref: P00629
standard name: protein phosphatase 2A
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: protein phosphatase 2A Synonym: Serine/threonine protein phosphatase 2A Accession: P00629
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.PP2A
member entity reference: Serine/threonine-protein phosphatase
member entity reference: Probable serine/threonine protein phosphatase 2A regulatory subunit B''gamma
member entity reference: Uncharacterized protein
member entity reference: Protein phosphatase PP2A regulatory subunit B
member entity reference: Serine/threonine-protein phosphatase 6 catalytic subunit
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
member entity reference: Serine/threonine protein phosphatase 2A regulatory subunit B''alpha
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
member entity reference: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
member entity reference: Serine/threonine-protein phosphatase 4 catalytic subunit
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
member entity reference: Protein phosphatase 2 (Formerly 2A), regulatory subunit A, beta isoform
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
member entity reference: Serine/threonine-protein phosphatase PP2A catalytic subunit
member entity reference: Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB
member entity reference: Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
member entity reference: Putative serine/threonine-protein phosphatase C26H8.05c
member entity reference: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform
member entity reference: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
member entity reference: Serine/threonine-protein phosphatase 2A regulatory subunit sur-6
member entity reference: Serine/threonine-protein phosphatase 4 catalytic subunit A
member entity reference: Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform
member entity reference: Protein phosphatase 2 scaffold subunit Abeta
member entity reference: Serine/threonine-protein phosphatase 4 catalytic subunit B
member entity reference: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
member entity reference: Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform
member entity reference: Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a
member entity reference: Protein phosphatase 2A scaffold subunit
member entity reference: Serine/threonine protein phosphatase 2A regulatory subunit
member entity reference: Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform
member entity reference: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
member entity reference: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
member entity reference: Protein phosphatase 2 scaffold subunit Aalpha
member entity reference: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
member entity reference: Protein phosphatase PP2A regulatory subunit A
member entity reference: Protein phosphatase 2 regulatory subunit A, beta
member entity reference: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

PTHR11486:SF25
type: RelationshipXref
id: PTHR11486:SF25
db: PANTHER Family
relationship type: By Homology

uniprot Q9QXV8 310
type: UnificationXref
id: Q9QXV8
db: uniprot

Sprouty RTK signaling antagonist 2
type: ProteinReference
xref: PTHR12365:SF8
xref: uniprot H2Q7P2 299
organism: Pan troglodytes

PTHR11486:SF23
type: RelationshipXref
id: PTHR11486:SF23
db: PANTHER Family
relationship type: By Homology

uniprot H2QHF1 185
type: UnificationXref
id: H2QHF1
db: uniprot

PTHR11486:SF21
type: RelationshipXref
id: PTHR11486:SF21
db: PANTHER Family
relationship type: By Homology

PTHR11486:SF20
type: RelationshipXref
id: PTHR11486:SF20
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
type: ProteinReference
xref: uniprot P23595 495
organism: Saccharomyces cerevisiae

uniprot Q7PVR1 353
type: UnificationXref
id: Q7PVR1
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot O42376 1017
xref: PTHR24055:SF146
organism: Danio rerio

uniprot P04627 995
type: UnificationXref
id: P04627
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q9Z1L0 937
xref: PTHR10048:SF33
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot F7E2C0 471
xref: PTHR11871:SF5
organism: Monodelphis domestica

GTPase NRas
type: ProteinReference
xref: uniprot P79737 722
xref: PTHR24070:SF189
organism: Danio rerio

Phosphatidylinositol 3-kinase piki-1
type: ProteinReference
xref: PTHR10048:SF64
xref: uniprot G5EDY0 902
organism: Caenorhabditis elegans

uniprot P03968 77
type: UnificationXref
id: P03968
db: uniprot

PTHR11486:SF28
type: RelationshipXref
id: PTHR11486:SF28
db: PANTHER Family
relationship type: By Homology

PTHR11486:SF27
type: RelationshipXref
id: PTHR11486:SF27
db: PANTHER Family
relationship type: By Homology

MEK1-2
type: Protein
entity reference: MEK1-2
feature: MEK1 2 s25 a28 rs2
feature: MEK1 2 s25 a28 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot H2RIH8 1118
xref: PTHR46559:SF1
organism: Pan troglodytes

uniprot H2QDQ1 1151
type: UnificationXref
id: H2QDQ1
db: uniprot

uniprot Q5QIT3 556
type: UnificationXref
id: Q5QIT3
db: uniprot

uniprot F7D0A6 829
type: UnificationXref
id: F7D0A6
db: uniprot

uniprot Q5F3W6 243
type: UnificationXref
id: Q5F3W6
db: uniprot

uniprot Q02111 1178
type: UnificationXref
id: Q02111
db: uniprot

Akt
type: Protein
entity reference: Akt
feature: ACTIVE 287
feature: Akt s22 a25 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Rac
type: Protein
entity reference: Rac
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q6P365 567
xref: PTHR45619:SF42
organism: Xenopus tropicalis

PTHR10194:SF19
type: RelationshipXref
id: PTHR10194:SF19
db: PANTHER Family
relationship type: By Homology

uniprot F6TXC2 1009
type: UnificationXref
id: F6TXC2
db: uniprot

uniprot F6U7A6 458
type: UnificationXref
id: F6U7A6
db: uniprot

Fibroblast growth factor receptor
type: ProteinReference
xref: PTHR24416:SF130
xref: uniprot H2Q2P3 803
organism: Pan troglodytes

Map2k3 protein
type: ProteinReference
xref: uniprot B1H230 272
xref: PTHR48013:SF21
organism: Rattus norvegicus

uniprot Q9WTQ0 1193
type: UnificationXref
id: Q9WTQ0
db: uniprot

uniprot A0A3Q1M739 1112
type: UnificationXref
id: A0A3Q1M739
db: uniprot

PTHR24356:SF333
type: RelationshipXref
id: PTHR24356:SF333
db: PANTHER Family
relationship type: By Homology

Protein kinase C-like 1B
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot P34885 1170
organism: Caenorhabditis elegans

uniprot A0A1D5QYU2 1110
type: UnificationXref
id: A0A1D5QYU2
db: uniprot

uniprot Q5A1D3 348
type: UnificationXref
id: Q5A1D3
db: uniprot

Ras protein let-60
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P22981 718
organism: Caenorhabditis elegans

uniprot F6YLW2 746
type: UnificationXref
id: F6YLW2
db: uniprot

RKIP
type: Protein
entity reference: RKIP
feature: RKIP s30 a33 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PTHR11486:SF17
type: RelationshipXref
id: PTHR11486:SF17
db: PANTHER Family
relationship type: By Homology

Rac family small GTPase 3a
type: ProteinReference
xref: uniprot Q6DGB7 1077
xref: PTHR24072:SF301
organism: Danio rerio

Dual-specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F1NYZ2 962
organism: Gallus gallus

uniprot P42337 917
type: UnificationXref
id: P42337
db: uniprot

uniprot F1PBL1 161
type: UnificationXref
id: F1PBL1
db: uniprot

PTHR11486:SF18
type: RelationshipXref
id: PTHR11486:SF18
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF80
xref: uniprot A0A2I3TDL0 404
organism: Pan troglodytes

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEK1_2-RIGHT__MEK1_2-_r9
controller: Raf-1

uniprot Q5PU49 1187
type: UnificationXref
id: Q5PU49
db: uniprot

uniprot E2R7W7 273
type: UnificationXref
id: E2R7W7
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot H2Q7R8 58
organism: Pan troglodytes

uniprot Q38950 548
type: UnificationXref
id: Q38950
db: uniprot

NRAS proto-oncogene, GTPase
type: ProteinReference
xref: uniprot F1PHV7 699
xref: PTHR24070:SF189
organism: Canis lupus familiaris

Stress-activated protein kinase jnk-1
type: ProteinReference
xref: uniprot Q8WQG9 387
organism: Caenorhabditis elegans

uniprot Q5ZIF0 978
type: UnificationXref
id: Q5ZIF0
db: uniprot

uniprot P91634 926
type: UnificationXref
id: P91634
db: uniprot

PTHR10194:SF3
type: RelationshipXref
id: PTHR10194:SF3
db: PANTHER Family
relationship type: By Homology

uniprot F1PXS7 322
type: UnificationXref
id: F1PXS7
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q2TY19 365
organism: Gallus gallus

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q5Z859 349
organism: Oryza sativa

uniprot A0A2I3T9Y4 659
type: UnificationXref
id: A0A2I3T9Y4
db: uniprot

uniprot Q8C180 782
type: UnificationXref
id: Q8C180
db: uniprot

NRAS isoform 1
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot H2PZQ7 704
organism: Pan troglodytes

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot E7EXT6 663
xref: PTHR24356:SF190
organism: Danio rerio

PTHR10194:SF4
type: RelationshipXref
id: PTHR10194:SF4
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 4 regulatory subunit 1
type: ProteinReference
xref: uniprot Q8VI02 590
organism: Rattus norvegicus

uniprot A8XQS8 1036
type: UnificationXref
id: A8XQS8
db: uniprot

uniprot P22455 811
type: UnificationXref
id: P22455
db: uniprot

uniprot F7HFS0 51
type: UnificationXref
id: F7HFS0
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7DUD6 896
xref: PTHR10048:SF107
organism: Ornithorhynchus anatinus

uniprot A0A2R8Q8S1 687
type: UnificationXref
id: A0A2R8Q8S1
db: uniprot

uniprot E2RNP2 1137
type: UnificationXref
id: E2RNP2
db: uniprot

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot A0A3Q1MNG1 271
xref: PTHR48013:SF21
organism: Bos taurus

uniprot O04375 487
type: UnificationXref
id: O04375
db: uniprot

PTHR24356:SF365
type: RelationshipXref
id: PTHR24356:SF365
db: PANTHER Family
relationship type: By Homology

uniprot F7G6M6 297
type: UnificationXref
id: F7G6M6
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q6EPR6 563
organism: Oryza sativa

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q95NE7 1029
xref: PTHR24055:SF110
organism: Pan troglodytes

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot H2QRH7 482
xref: PTHR45619:SF42
organism: Pan troglodytes

uniprot A0NBA9 877
type: UnificationXref
id: A0NBA9
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot F1N6G8 26
xref: PTHR11486:SF3
organism: Bos taurus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6QP11 668
organism: Monodelphis domestica

uniprot F6SXE2 38
type: UnificationXref
id: F6SXE2
db: uniprot

Fibroblast growth factor 8
type: ProteinReference
xref: uniprot P37237 94
organism: Mus musculus

A-Raf proto-oncogene, serine/threonine kinase
type: ProteinReference
xref: uniprot E2RL20 990
organism: Canis lupus familiaris

uniprot Q5TKR3 118
type: UnificationXref
id: Q5TKR3
db: uniprot

PTHR10194:SF21
type: RelationshipXref
id: PTHR10194:SF21
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 3
type: ProteinReference
xref: PTHR24055:SF393
xref: uniprot Q63844 350
organism: Mus musculus

Rho-related protein racC
type: ProteinReference
xref: uniprot P34149 1059
xref: PTHR24072:SF310
organism: Dictyostelium discoideum

uniprot F7BIC2 1144
type: UnificationXref
id: F7BIC2
db: uniprot

Rho-related protein racA
type: ProteinReference
xref: uniprot P34147 1057
xref: PTHR24072:SF301
organism: Dictyostelium discoideum

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A8XTZ1 842
organism: Caenorhabditis briggsae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK4,7-RIGHT__MKK4,7-_r23
controller: MEKK1-5

PARTICIPANT STOICHIOMETRY r8 1258
type: Stoichiometry
physical entity: Raf-1
stoichiometric coefficient: 1.0

Rho-related protein racB
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34148 1058
organism: Dictyostelium discoideum

uniprot F1PV54 451
type: UnificationXref
id: F1PV54
db: uniprot

PARTICIPANT STOICHIOMETRY r8 1259
type: Stoichiometry
physical entity: Raf-1
stoichiometric coefficient: 1.0

Rho-related protein rac1B
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34145 1055
organism: Dictyostelium discoideum

uniprot H2QT14 483
type: UnificationXref
id: H2QT14
db: uniprot

Rho-related protein rac1C
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34146 1056
organism: Dictyostelium discoideum

uniprot A0A3Q1MNG1 271
type: UnificationXref
id: A0A3Q1MNG1
db: uniprot

Rho-related protein rac1A
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P34144 1054
organism: Dictyostelium discoideum

uniprot F1N1S8 447
type: UnificationXref
id: F1N1S8
db: uniprot

uniprot P10686 849
type: UnificationXref
id: P10686
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9I7L3 637
organism: Drosophila melanogaster

PARTICIPANT STOICHIOMETRY r34 1234
type: Stoichiometry
physical entity: Complex (SOS/Grb2)
stoichiometric coefficient: 1.0

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Survival Apoptosis cell migration
controller: p38

PARTICIPANT STOICHIOMETRY r34 1235
type: Stoichiometry
physical entity: SHC
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 1236
type: Stoichiometry
physical entity: Complex (FGFR1-4/PLC_gamma/ RasGAP/PI3K/ FRS2/SHP2/ SHC/Grb2/ SOS)
stoichiometric coefficient: 1.0

p38
type: Protein
entity reference: p38
feature: ACTIVE 287
feature: p38 s54 a67 rs1
feature: p38 s54 a67 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot E1C021 775
xref: PTHR21258:SF40
organism: Gallus gallus

Mitogen-activated protein kinase FUS3
type: ProteinReference
xref: uniprot P16892 333
xref: PTHR24055:SF158
organism: Saccharomyces cerevisiae

uniprot F7C5Z9 467
type: UnificationXref
id: F7C5Z9
db: uniprot

uniprot H2Q411 479
type: UnificationXref
id: H2Q411
db: uniprot

uniprot Q0V9W8 235
type: UnificationXref
id: Q0V9W8
db: uniprot

ncbitaxon 5664 977
type: UnificationXref
id: 5664
db: ncbitaxon

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot H2QDN0 751
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r34 1231
type: Stoichiometry
physical entity: RasGAP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 1230
type: Stoichiometry
physical entity: PLCgamma
stoichiometric coefficient: 1.0

Fibroblast growth factor
type: ProteinReference
xref: uniprot A0A1D5PML4 3
xref: PTHR11486:SF77
organism: Gallus gallus

PARTICIPANT STOICHIOMETRY r34 1233
type: Stoichiometry
physical entity: SHP2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r34 1232
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 2.0

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F7BWW9 946
xref: PTHR23113:SF168
organism: Ornithorhynchus anatinus

uniprot Q9WTY9 1033
type: UnificationXref
id: Q9WTY9
db: uniprot

Mitogen-activated protein kinase 4
type: ProteinReference
xref: uniprot Q39024 345
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 7
type: ProteinReference
xref: uniprot Q39027 347
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 6
type: ProteinReference
xref: uniprot Q39026 346
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q39021 342
organism: Arabidopsis thaliana

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot F6TA21 166
organism: Monodelphis domestica

Fibroblast growth factor receptor substrate 3
type: ProteinReference
xref: uniprot Q91WJ0 784
organism: Mus musculus

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q39023 344
organism: Arabidopsis thaliana

Mitogen-activated protein kinase 2
type: ProteinReference
xref: uniprot Q39022 343
organism: Arabidopsis thaliana

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q62074 1188
organism: Mus musculus

PTHR46037:SF4
type: RelationshipXref
id: PTHR46037:SF4
db: PANTHER Family
relationship type: By Homology

uniprot A3C4N5 410
type: UnificationXref
id: A3C4N5
db: uniprot

GRB2-related adapter protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot Q13588 652
organism: Homo sapiens

00696
type: UnificationXref
id: MOD:00696
db: mod

PTHR11486:SF145
type: RelationshipXref
id: PTHR11486:SF145
db: PANTHER Family
relationship type: By Homology

uniprot Q62077 853
type: UnificationXref
id: Q62077
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot Q62077 853
xref: PTHR10336:SF173
organism: Mus musculus

Protein phosphatase 2 regulatory subunit A, alpha
type: ProteinReference
xref: uniprot F6QT86 455
xref: PTHR10648:SF2
organism: Xenopus tropicalis

uniprot A0A452DI16 988
type: UnificationXref
id: A0A452DI16
db: uniprot

uniprot P54632 212
type: UnificationXref
id: P54632
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2RA86 330
xref: PTHR24055:SF393
organism: Pan troglodytes

uniprot Q54Q99 552
type: UnificationXref
id: Q54Q99
db: uniprot

Fibroblast growth factor 12
type: ProteinReference
xref: uniprot P61328 105
xref: PTHR11486:SF17
organism: Homo sapiens

uniprot Q7QFY4 576
type: UnificationXref
id: Q7QFY4
db: uniprot

Growth factor receptor-bound protein 2
type: ProteinReference
xref: uniprot Q60631 655
xref: PTHR46037:SF4
organism: Mus musculus

PTHR46037:SF2
type: RelationshipXref
id: PTHR46037:SF2
db: PANTHER Family
relationship type: By Homology

PTHR46037:SF1
type: RelationshipXref
id: PTHR46037:SF1
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor 14
type: ProteinReference
xref: uniprot P70379 112
xref: PTHR11486:SF18
organism: Mus musculus

Fibroblast growth factor 12
type: ProteinReference
xref: PTHR11486:SF17
xref: uniprot P61329 106
organism: Mus musculus

Fibroblast growth factor 11
type: ProteinReference
xref: uniprot P70378 111
xref: PTHR11486:SF67
organism: Mus musculus

Fibroblast growth factor 13
type: ProteinReference
xref: PTHR11486:SF145
xref: uniprot P70377 110
organism: Mus musculus

PTHR24070:SF206
type: RelationshipXref
id: PTHR24070:SF206
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot Q99759 765
organism: Homo sapiens

Physcomitrella patens
type: BioSource
xref: ncbitaxon 3218 423

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A1D5Q6M6 396
xref: PTHR10257:SF6
organism: Macaca mulatta

uniprot P87253 1177
type: UnificationXref
id: P87253
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF4
xref: uniprot F7F2X9 47
organism: Monodelphis domestica

uniprot B7U3Y1 16
type: UnificationXref
id: B7U3Y1
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FGFR1_4-RIGHT__FGFR1_4-_r18
controller: FGF

Fibroblast growth factor
type: ProteinReference
xref: uniprot Q5TKR3 118
xref: PTHR11486:SF17
organism: Danio rerio

uniprot Q8LF36 588
type: UnificationXref
id: Q8LF36
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot Q5TKR1 117
organism: Danio rerio

Spry
type: Protein
entity reference: Spry
feature: Spry s11 a10 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P63075 108
type: UnificationXref
id: P63075
db: uniprot

uniprot F0ZLW0 442
type: UnificationXref
id: F0ZLW0
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F6XL57 463
xref: PTHR10257:SF6
organism: Ornithorhynchus anatinus

SHP2
type: Protein
entity reference: SHP2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q92913 122
type: UnificationXref
id: Q92913
db: uniprot

Protein phosphatase 2 scaffold subunit Aalpha
type: ProteinReference
xref: uniprot F6RLB3 456
xref: PTHR10648:SF2
organism: Monodelphis domestica

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7H808 476
xref: PTHR45619:SF42
organism: Macaca mulatta

uniprot H2Q7A1 57
type: UnificationXref
id: H2Q7A1
db: uniprot

uniprot P32252 719
type: UnificationXref
id: P32252
db: uniprot

p38
type: ProteinReference
xref: P00644
standard name: p38 mitogen activated protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.p38
comment: ENTITY_REFERENCE_NOTES= Long Name: p38 MAP kinase Synonym: mitogen-activated protein kinase 11,mitogen-activated protein kinase 14 isoform 4 Accession: P00644
member entity reference: Mitogen-activated protein kinase
member entity reference: Mitogen-activated protein kinase 14
member entity reference: Mitogen-activated protein kinase 12
member entity reference: Mitogen-activated protein kinase pmk-1
member entity reference: Mitogen-activated protein kinase 13
member entity reference: Mitogen-activated protein kinase pmk-2
member entity reference: Mitogen-activated protein kinase 14A
member entity reference: Mitogen-activated protein kinase 11
member entity reference: Mitogen-activated protein kinase p38b
member entity reference: Mitogen-activated protein kinase 14B
member entity reference: Mitogen-activated protein kinase p38a

uniprot P36582 1171
type: UnificationXref
id: P36582
db: uniprot

PARTICIPANT STOICHIOMETRY r34 1229
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

uniprot P63151 517
type: UnificationXref
id: P63151
db: uniprot

PARTICIPANT STOICHIOMETRY r34 1228
type: Stoichiometry
physical entity: FRS2
stoichiometric coefficient: 1.0

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot K7CBH8 1153
organism: Pan troglodytes

uniprot Q9I7L3 637
type: UnificationXref
id: Q9I7L3
db: uniprot

uniprot Q9JHG7 935
type: UnificationXref
id: Q9JHG7
db: uniprot

PTHR24356:SF390
type: RelationshipXref
id: PTHR24356:SF390
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF110
xref: uniprot F6YAB9 1011
organism: Monodelphis domestica

SHC
type: Protein
entity reference: SHC
feature: COMPLEX PARTICIPANT BINDING FEATURE s32 sa12 1217
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF2
xref: uniprot E2R0J6 436
organism: Canis lupus familiaris

MAP3K2 isoform 1
type: ProteinReference
xref: uniprot H2QIN7 752
xref: PTHR24361:SF342
organism: Pan troglodytes

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C4M8K6 1043
organism: Entamoeba histolytica

Multifunctional chaperone, putative
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot B7Q5I4 146
organism: Ixodes scapularis

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XT65 964
xref: PTHR48013:SF5
organism: Monodelphis domestica

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2QS62 377
organism: Pan troglodytes

Putative odorant-binding protein A5
type: ProteinReference
xref: uniprot P54185 624
xref: PTHR11362:SF131
organism: Drosophila melanogaster

uniprot F7B5L8 374
type: UnificationXref
id: F7B5L8
db: uniprot

Grb2 s2 sa2 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

uniprot F6XL57 463
type: UnificationXref
id: F6XL57
db: uniprot

uniprot P62715 515
type: UnificationXref
id: P62715
db: uniprot

uniprot Q9VK60 644
type: UnificationXref
id: Q9VK60
db: uniprot

Serine/threonine-protein phosphatase 4 catalytic subunit B
type: ProteinReference
xref: uniprot A9JRC7 421
organism: Danio rerio

uniprot P70296 625
type: UnificationXref
id: P70296
db: uniprot

uniprot F6YFR4 800
type: UnificationXref
id: F6YFR4
db: uniprot

Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot D3ZTF6 879
organism: Rattus norvegicus

uniprot P48423 1104
type: UnificationXref
id: P48423
db: uniprot

uniprot A0A2I3T7V6 10
type: UnificationXref
id: A0A2I3T7V6
db: uniprot

Ras-like protein
type: ProteinReference
xref: uniprot Q12526 724
xref: PTHR24070:SF17
organism: Emericella nidulans

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A4FV00 366
xref: PTHR24055:SF162
organism: Bos taurus

uniprot P08487 848
type: UnificationXref
id: P08487
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7CYE3 375
xref: PTHR24055:SF162
organism: Xenopus tropicalis

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
type: ProteinReference
xref: uniprot Q10BT5 534
organism: Oryza sativa

uniprot Q66LE6 562
type: UnificationXref
id: Q66LE6
db: uniprot

uniprot O08648 756
type: UnificationXref
id: O08648
db: uniprot

Ras-like protein 1
type: ProteinReference
xref: uniprot Q59XU5 727
xref: PTHR24070:SF17
organism: Candida albicans

uniprot F1MIH6 294
type: UnificationXref
id: F1MIH6
db: uniprot

uniprot F1Q6Z7 453
type: UnificationXref
id: F1Q6Z7
db: uniprot

uniprot P52564 282
type: UnificationXref
id: P52564
db: uniprot

uniprot A9SKN8 424
type: UnificationXref
id: A9SKN8
db: uniprot

uniprot Q7Q334 866
type: UnificationXref
id: Q7Q334
db: uniprot

Growth factor receptor-bound protein 2a
type: ProteinReference
xref: uniprot Q5RKN6 654
xref: PTHR46037:SF4
organism: Danio rerio

uniprot P70236 283
type: UnificationXref
id: P70236
db: uniprot

uniprot F0ZN94 1044
type: UnificationXref
id: F0ZN94
db: uniprot

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot A0A2I3RB56 270
organism: Pan troglodytes

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot P46734 281
organism: Homo sapiens

uniprot P15656 87
type: UnificationXref
id: P15656
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot Q8AXX6 584
xref: PTHR10257:SF92
organism: Danio rerio

uniprot Q53Q71 629
type: UnificationXref
id: Q53Q71
db: uniprot

uniprot H9EU39 1152
type: UnificationXref
id: H9EU39
db: uniprot

uniprot F1N795 1096
type: UnificationXref
id: F1N795
db: uniprot

PIK3C2A isoform 5
type: ProteinReference
xref: uniprot H2Q383 904
xref: PTHR10048:SF28
organism: Pan troglodytes

PTHR12874:SF9
type: RelationshipXref
id: PTHR12874:SF9
db: PANTHER Family
relationship type: By Homology

uniprot J9NT83 780
type: UnificationXref
id: J9NT83
db: uniprot

…
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 2.0

Protein kinase C eta type
type: ProteinReference
xref: uniprot F1MY82 1140
xref: PTHR24356:SF192
organism: Bos taurus

uniprot P29355 650
type: UnificationXref
id: P29355
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot A0A3Q2U4X3 661
organism: Gallus gallus

uniprot A0A1D5R2V9 787
type: UnificationXref
id: A0A1D5R2V9
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MEKK1_5-RIGHT__MEKK1_5-_r30
controller: Rac

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZTS0 1012
xref: PTHR24055:SF146
organism: Macaca mulatta

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF2
xref: uniprot A0A1D5PED5 394
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot F6USY2 745
organism: Monodelphis domestica

FRS3 protein
type: ProteinReference
xref: uniprot A6H792 772
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: uniprot H2QDQ1 1151
xref: PTHR24356:SF193
organism: Pan troglodytes

RasGAP-activating-like protein 1
type: ProteinReference
xref: uniprot Q9Z268 1109
xref: PTHR10194:SF3
organism: Mus musculus

uniprot P68250 225
type: UnificationXref
id: P68250
db: uniprot

PTHR44329:SF22
type: RelationshipXref
id: PTHR44329:SF22
db: PANTHER Family
relationship type: By Homology

uniprot E2QSI0 776
type: UnificationXref
id: E2QSI0
db: uniprot

Fibroblast growth factor 1
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot P19596 88
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot F7HPR8 858
organism: Macaca mulatta

uniprot Q5RKN6 654
type: UnificationXref
id: Q5RKN6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot P19174 851
organism: Homo sapiens

uniprot F1N7C3 940
type: UnificationXref
id: F1N7C3
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot Q6RUV5 1081
xref: PTHR24072:SF105
organism: Rattus norvegicus

uniprot F1MHC6 25
type: UnificationXref
id: F1MHC6
db: uniprot

SHP2
type: Protein
entity reference: SHP2
feature: COMPLEX PARTICIPANT BINDING FEATURE s20 sa11 1215
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot A0A1D5QE27 871
organism: Macaca mulatta

Serine/threonine-protein phosphatase 4 regulatory subunit 1
type: ProteinReference
xref: uniprot Q8K2V1 587
organism: Mus musculus

Multifunctional fusion protein
type: ProteinReference
xref: uniprot A0A2J8NIY5 13
xref: PTHR11486:SF86
organism: Pan troglodytes

Uncharacterized protein rasD
type: ProteinReference
xref: uniprot F0ZB76 694
xref: PTHR24070:SF418
organism: Dictyostelium purpureum

Rac-like GTP-binding protein 4
type: ProteinReference
xref: PTHR24072:SF315
xref: uniprot Q67VP4 1075
organism: Oryza sativa

PTHR11486:SF86
type: RelationshipXref
id: PTHR11486:SF86
db: PANTHER Family
relationship type: By Homology

PTHR46559:SF3
type: RelationshipXref
id: PTHR46559:SF3
db: PANTHER Family
relationship type: By Homology

uniprot H2QUT2 186
type: UnificationXref
id: H2QUT2
db: uniprot

Os09g0249700 protein
type: ProteinReference
xref: uniprot Q6K4K9 565
organism: Oryza sativa

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF5
xref: uniprot F1MY94 446
organism: Bos taurus

PTHR46559:SF1
type: RelationshipXref
id: PTHR46559:SF1
db: PANTHER Family
relationship type: By Homology

uniprot Q10428 533
type: UnificationXref
id: Q10428
db: uniprot

Sprouty RTK signaling antagonist 4
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot H2QRP3 301
organism: Pan troglodytes

Fibroblast growth factor 9
type: ProteinReference
xref: uniprot P54130 100
organism: Mus musculus

uniprot Q38845 547
type: UnificationXref
id: Q38845
db: uniprot

uniprot G7MHX1 184
type: UnificationXref
id: G7MHX1
db: uniprot

Multifunctional fusion protein
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot F6WG78 39
organism: Ornithorhynchus anatinus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A0G2K5T3 870
xref: PTHR10048:SF107
organism: Rattus norvegicus

Apoptotic signal-regulating kinase 1, isoform C
type: ProteinReference
xref: uniprot Q9VDS9 766
organism: Drosophila melanogaster

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: PTHR46257:SF4
xref: uniprot I0FMS6 1119
organism: Macaca mulatta

uniprot P68510 229
type: UnificationXref
id: P68510
db: uniprot

uniprot P61981 214
type: UnificationXref
id: P61981
db: uniprot

CEN-like protein 2, putative, expressed
type: ProteinReference
xref: uniprot Q53Q71 629
organism: Oryza sativa

uniprot K7CFQ9 755
type: UnificationXref
id: K7CFQ9
db: uniprot

PTHR11486:SF83
type: RelationshipXref
id: PTHR11486:SF83
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6U7A6 458
xref: PTHR45619:SF42
organism: Monodelphis domestica

Complex (SOS/Grb2)
type: Complex
component stoichiometry: SOS s37 sa15 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s41 sa16 STOICHIOMETRY ID COMPLEX
component: SOS
component: Grb2
feature: COMPLEX BINDING FEATURE s75 a98 1202
feature: COMPLEX BINDING FEATURE s75 a98 1200
cellular location: cytoplasm

Spry s14 a13 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

PTHR11486:SF77
type: RelationshipXref
id: PTHR11486:SF77
db: PANTHER Family
relationship type: By Homology

uniprot P12034 84
type: UnificationXref
id: P12034
db: uniprot

uniprot P92208 385
type: UnificationXref
id: P92208
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot F7DGH9 178
organism: Ornithorhynchus anatinus

uniprot E1BMG4 1133
type: UnificationXref
id: E1BMG4
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7EI48 327
xref: PTHR24055:SF393
organism: Monodelphis domestica

Serine/threonine-protein phosphatase 6 catalytic subunit
type: ProteinReference
xref: uniprot Q27884 544
organism: Drosophila melanogaster

uniprot P47196 678
type: UnificationXref
id: P47196
db: uniprot

Rac family small GTPase 1b
type: ProteinReference
xref: uniprot Q29RC5 1068
xref: PTHR24072:SF105
organism: Danio rerio

MAP kinase kinase 4, isoform A
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot O61444 832
organism: Drosophila melanogaster

uniprot Q95NE7 1029
type: UnificationXref
id: Q95NE7
db: uniprot

Mitogen-activated protein kinase p38b
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot O61443 1018
organism: Drosophila melanogaster

Phosphatidylethanolamine-binding protein 1
type: ProteinReference
xref: uniprot P31044 623
xref: PTHR11362:SF10
organism: Rattus norvegicus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q567Y8 554
xref: PTHR45619:SF42
organism: Danio rerio

uniprot E1BWA3 1135
type: UnificationXref
id: E1BWA3
db: uniprot

p38 s53 a66 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F7GEK1 672
xref: PTHR24356:SF190
organism: Monodelphis domestica

uniprot P18461 807
type: UnificationXref
id: P18461
db: uniprot

uniprot P93003 626
type: UnificationXref
id: P93003
db: uniprot

uniprot P42336 916
type: UnificationXref
id: P42336
db: uniprot

uniprot A0A1D5QYN7 786
type: UnificationXref
id: A0A1D5QYN7
db: uniprot

14-3-3 zeta
type: ProteinReference
xref: uniprot E9H1W5 158
xref: PTHR18860:SF106
organism: Daphnia pulex

uniprot A0A0R4IKK9 361
type: UnificationXref
id: A0A0R4IKK9
db: uniprot

Sclerotinia sclerotiorum
type: BioSource
xref: ncbitaxon 665079 317

uniprot F7H4H9 182
type: UnificationXref
id: F7H4H9
db: uniprot

Ras-like protein rasB
type: ProteinReference
xref: PTHR24070:SF206
xref: uniprot P32252 719
organism: Dictyostelium discoideum

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot F7DLW2 469
xref: PTHR11871:SF2
organism: Monodelphis domestica

AGAP000018-PA
type: ProteinReference
xref: uniprot Q7QEJ7 931
xref: PTHR10048:SF14
organism: Anopheles gambiae

Ras-like protein rasS
type: ProteinReference
xref: PTHR24070:SF380
xref: uniprot P32254 721
organism: Dictyostelium discoideum

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF2
xref: uniprot F7AB62 465
organism: Xenopus tropicalis

Ras-like protein rasC
type: ProteinReference
xref: uniprot P32253 720
xref: PTHR24070:SF251
organism: Dictyostelium discoideum

uniprot P61149 103
type: UnificationXref
id: P61149
db: uniprot

14-3-3-like protein GF14-F
type: ProteinReference
xref: PTHR18860:SF103
xref: uniprot Q06967 233
organism: Oryza sativa

PEBP1 isoform 1
type: ProteinReference
xref: PTHR11362:SF109
xref: uniprot H2Q6Z4 619
organism: Pan troglodytes

uniprot F6RA79 1141
type: UnificationXref
id: F6RA79
db: uniprot

uniprot Q61084 762
type: UnificationXref
id: Q61084
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A0G2JTA1 391
xref: PTHR10257:SF92
organism: Rattus norvegicus

uniprot H2Q7P2 299
type: UnificationXref
id: H2Q7P2
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q10R90 535
xref: PTHR45619:SF25
organism: Oryza sativa

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot E2QZT7 155
organism: Canis lupus familiaris

uniprot Q9Z1L0 937
type: UnificationXref
id: Q9Z1L0
db: uniprot

uniprot O43610 304
type: UnificationXref
id: O43610
db: uniprot

uniprot Q99683 764
type: UnificationXref
id: Q99683
db: uniprot

uniprot P32871 915
type: UnificationXref
id: P32871
db: uniprot

uniprot E2RIF9 884
type: UnificationXref
id: E2RIF9
db: uniprot

JNK1 3 s50 a63 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot P22543 914
organism: Saccharomyces cerevisiae

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot E1BMX0 692
organism: Bos taurus

uniprot P20936 1103
type: UnificationXref
id: P20936
db: uniprot

SHC-transforming protein 3
type: ProteinReference
xref: uniprot Q92529 867
xref: PTHR10337:SF4
organism: Homo sapiens

Entamoeba histolytica
type: BioSource
xref: ncbitaxon 5759 151

MEKK1 5 s38 a40 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot E1B8P9 320
type: UnificationXref
id: E1B8P9
db: uniprot

ISS
type: EvidenceCodeVocabulary
xref: eco ECO:0000250 9

uniprot O04951 489
type: UnificationXref
id: O04951
db: uniprot

uniprot F7H3B3 1147
type: UnificationXref
id: F7H3B3
db: uniprot

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot F1N339 1113
xref: PTHR46559:SF1
organism: Bos taurus

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot F1PXD3 274
xref: PTHR48013:SF21
organism: Canis lupus familiaris

ERK1 2 s28 a31 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot P13696 621
type: UnificationXref
id: P13696
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9Z1B7 1035
xref: PTHR24055:SF107
organism: Mus musculus

uniprot P63076 109
type: UnificationXref
id: P63076
db: uniprot

Fibroblast growth factor 11
type: ProteinReference
xref: uniprot Q92914 123
organism: Homo sapiens

Fibroblast growth factor 13
type: ProteinReference
xref: PTHR11486:SF145
xref: uniprot Q92913 122
organism: Homo sapiens

Fibroblast growth factor 14
type: ProteinReference
xref: uniprot Q92915 124
xref: PTHR11486:SF18
organism: Homo sapiens

SHP2
type: ProteinReference
xref: P00647
standard name: Src homology 2 domain-containing tyrosine phosphatase 2
comment: ENTITY_REFERENCE_NOTES= Long Name: Src homology 2 domain-containing tyrosine phosphatase 2 Synonym: non-receptor type 11,protein tyrosine phosphatase,protein-tyrosine phosphatase 2C Accession: P00647
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.SHP2
member entity reference: Tyrosine-protein phosphatase non-receptor type
member entity reference: Tyrosine-protein phosphatase non-receptor type ptp-2
member entity reference: Tyrosine-protein phosphatase non-receptor type 6
member entity reference: Tyrosine-protein phosphatase corkscrew
member entity reference: Tyrosine-protein phosphatase non-receptor type 11

uniprot F1MXH6 742
type: UnificationXref
id: F1MXH6
db: uniprot

uniprot P21658 89
type: UnificationXref
id: P21658
db: uniprot

14-3-3-like protein GF14-E
type: ProteinReference
xref: uniprot Q6EUP4 254
xref: PTHR12874:SF9
organism: Oryza sativa

SHC
type: ProteinReference
xref: P00639
standard name: Src homology 2 domain-containing transforming protein 1
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.SHC
comment: ENTITY_REFERENCE_NOTES= Long Name: Src homology 2 domain-containing transforming protein 1 Synonym: pp46/52/66 Accession: P00639
member entity reference: SHC-transforming protein 3
member entity reference: Uncharacterized protein
member entity reference: SHC-transforming protein 1
member entity reference: AGAP011463-PA
member entity reference: SHC adaptor protein 3
member entity reference: DShc protein
member entity reference: SHC (Src homology 2 domain containing) transforming protein 1

uniprot P11345 998
type: UnificationXref
id: P11345
db: uniprot

uniprot P78759 522
type: UnificationXref
id: P78759
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot P48463 509
organism: Gallus gallus

uniprot A0A1D5R393 397
type: UnificationXref
id: A0A1D5R393
db: uniprot

uniprot A0A2I3RB56 270
type: UnificationXref
id: A0A2I3RB56
db: uniprot

uniprot H2QS62 377
type: UnificationXref
id: H2QS62
db: uniprot

uniprot F6XP81 671
type: UnificationXref
id: F6XP81
db: uniprot

Protein ras-1
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot P22126 717
organism: Neurospora crassa

Monodelphis domestica
type: BioSource
xref: ncbitaxon 13616 31

uniprot Q4R0X9 116
type: UnificationXref
id: Q4R0X9
db: uniprot

uniprot P31750 676
type: UnificationXref
id: P31750
db: uniprot

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot F6VYS9 798
organism: Xenopus tropicalis

uniprot F7CYE3 375
type: UnificationXref
id: F7CYE3
db: uniprot

ERK1 2 s28 a31 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot P31938 967
type: UnificationXref
id: P31938
db: uniprot

STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 1258
participant stoichiometry: PARTICIPANT STOICHIOMETRY r8 1259
left: Raf-1
interaction type: STATE_TRANSITION
right: Raf-1

Protein FLOWERING LOCUS T
type: ProteinReference
xref: uniprot Q9SXZ2 639
organism: Arabidopsis thaliana

uniprot E2RSB0 1008
type: UnificationXref
id: E2RSB0
db: uniprot

uniprot B5DF98 736
type: UnificationXref
id: B5DF98
db: uniprot

Sprouty RTK signaling antagonist 2
type: ProteinReference
xref: PTHR12365:SF8
xref: uniprot E2RGU9 293
organism: Canis lupus familiaris

uniprot Q5F352 728
type: UnificationXref
id: Q5F352
db: uniprot

uniprot P34730 200
type: UnificationXref
id: P34730
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: uniprot E2RGU7 1136
xref: PTHR24356:SF192
organism: Canis lupus familiaris

Protein phosphatase 2, regulatory subunit A, beta a
type: ProteinReference
xref: uniprot A5PMV7 413
organism: Danio rerio

uniprot F1Q118 942
type: UnificationXref
id: F1Q118
db: uniprot

uniprot F7AKA6 747
type: UnificationXref
id: F7AKA6
db: uniprot

p38 s53 a66 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

JNK1-3
type: ProteinReference
xref: P00628
standard name: C-jun-amino-terminal kinase 1, 2, and 3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: C-jun-amino-terminal kinase 1, 2, and 3 Synonym: SAPK,stress-activated protein kinase Accession: P00628
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.JNK1_minus_3
member entity reference: Mitogen-activated protein kinase 10
member entity reference: Mitogen-activated protein kinase 9
member entity reference: Mitogen-activated protein kinase
member entity reference: Stress-activated protein kinase jnk-1
member entity reference: Mitogen-activated protein kinase 8
member entity reference: Stress-activated protein kinase JNK

uniprot Q9XTT8 605
type: UnificationXref
id: Q9XTT8
db: uniprot

uniprot P30086 622
type: UnificationXref
id: P30086
db: uniprot

Dual specificity mitogen-activated protein kinase kinase hemipterous
type: ProteinReference
xref: uniprot Q23977 835
organism: Drosophila melanogaster

Fibroblast growth factor 18
type: ProteinReference
xref: PTHR11486:SF4
xref: uniprot O89101 76
organism: Mus musculus

IEP
type: EvidenceCodeVocabulary
xref: eco ECO:0000270 107

Protein CBG05964
type: ProteinReference
xref: uniprot A8X180 615
organism: Caenorhabditis briggsae

STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r19
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1250
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1249
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1251
participant stoichiometry: PARTICIPANT STOICHIOMETRY r19 1248
left: Ras
left: GDP
interaction type: STATE_TRANSITION
right: Ras
right: GTP

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF4
xref: uniprot E2RTC7 24
organism: Canis lupus familiaris

PTHR24072:SF281
type: RelationshipXref
id: PTHR24072:SF281
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6ZKB3 373
organism: Macaca mulatta

uniprot C4LXB1 150
type: UnificationXref
id: C4LXB1
db: uniprot

uniprot H2QCA7 830
type: UnificationXref
id: H2QCA7
db: uniprot

uniprot Q7PR35 575
type: UnificationXref
id: Q7PR35
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7G3I5 899
xref: PTHR10048:SF107
organism: Monodelphis domestica

uniprot Q10BT5 534
type: UnificationXref
id: Q10BT5
db: uniprot

14-3-3 protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot Q5ZKC9 249
organism: Gallus gallus

uniprot F0ZDS0 441
type: UnificationXref
id: F0ZDS0
db: uniprot

SHC (Src homology 2 domain containing) transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot H2R8L2 859
organism: Pan troglodytes

Sprouty homolog 4 (Drosophila)
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot F1QZW4 296
organism: Danio rerio

Fibroblast growth factor 2
type: ProteinReference
xref: uniprot P48800 96
organism: Gallus gallus

Fibroblast growth factor 3
type: ProteinReference
xref: uniprot P48802 98
xref: PTHR11486:SF26
organism: Danio rerio

Fibroblast growth factor 3
type: ProteinReference
xref: uniprot P48801 97
xref: PTHR11486:SF26
organism: Gallus gallus

uniprot J9P0B3 66
type: UnificationXref
id: J9P0B3
db: uniprot

uniprot P11403 82
type: UnificationXref
id: P11403
db: uniprot

uniprot F7DGH9 178
type: UnificationXref
id: F7DGH9
db: uniprot

uniprot Q8UUX0 684
type: UnificationXref
id: Q8UUX0
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6WV79 371
organism: Monodelphis domestica

uniprot F1NYZ2 962
type: UnificationXref
id: F1NYZ2
db: uniprot

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot F6SM70 797
xref: PTHR24416:SF131
organism: Ornithorhynchus anatinus

uniprot F7C2I9 466
type: UnificationXref
id: F7C2I9
db: uniprot

Protein CBR-LET-60
type: ProteinReference
xref: uniprot A8X0X5 691
xref: PTHR24070:SF420
organism: Caenorhabditis briggsae

MEKK1 5 s38 a40 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot A0A2I3RMA9 788
xref: PTHR24416:SF131
organism: Pan troglodytes

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot O08648 756
organism: Mus musculus

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Survival Apoptosis cell migration
controller: JNK1-3

PTHR24072:SF287
type: RelationshipXref
id: PTHR24072:SF287
db: PANTHER Family
relationship type: By Homology

uniprot O44783 305
type: UnificationXref
id: O44783
db: uniprot

uniprot Q92915 124
type: UnificationXref
id: Q92915
db: uniprot

PTHR24072:SF289
type: RelationshipXref
id: PTHR24072:SF289
db: PANTHER Family
relationship type: By Homology

eco ECO:0000270 107
type: UnificationXref
id: ECO:0000270
db: eco

uniprot Q63538 1027
type: UnificationXref
id: Q63538
db: uniprot

Phosphatidylethanolamine-binding protein 1
type: ProteinReference
xref: PTHR11362:SF10
xref: uniprot P70296 625
organism: Mus musculus

ncbitaxon 10090 71
type: UnificationXref
id: 10090
db: ncbitaxon

Phosphatidylethanolamine-binding protein 1
type: ProteinReference
xref: PTHR11362:SF82
xref: uniprot P13696 621
organism: Bos taurus

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P47811 1020
xref: PTHR24055:SF110
organism: Mus musculus

uniprot A5PJP8 825
type: UnificationXref
id: A5PJP8
db: uniprot

Fibroblast growth factor receptor 2
type: ProteinReference
xref: PTHR24416:SF130
xref: uniprot P18461 807
organism: Gallus gallus

Fibroblast growth factor receptor 3
type: ProteinReference
xref: uniprot P18460 806
organism: Gallus gallus

uniprot K9J7P6 486
type: UnificationXref
id: K9J7P6
db: uniprot

14-3-3 family protein
type: ProteinReference
xref: uniprot F4I1B7 163
organism: Arabidopsis thaliana

Serine/threonine-protein phosphatase 4 catalytic subunit
type: ProteinReference
xref: uniprot Q9Y0B7 608
organism: Dictyostelium discoideum

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 985
evidence: Evidence 986
evidence: Evidence 983
evidence: Evidence 984
xref: PTHR44329:SF22
xref: uniprot A0A2I3THL4 987
organism: Pan troglodytes

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 164

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
control type: INHIBITION
controller: 14-3-3

uniprot P15064 716
type: UnificationXref
id: P15064
db: uniprot

JNK1 3 s50 a63 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A3Q1NH21 660
xref: PTHR24356:SF176
organism: Bos taurus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7GAP5 900
organism: Ornithorhynchus anatinus

Fibroblast growth factor
type: ProteinReference
xref: uniprot H2Q7A1 57
organism: Pan troglodytes

HETERODIMER_ASSOCIATION_LEFT__FGFR1_4-_Complex__Grb2_SOS_-RIGHT__Complex__FGFR1_4_Grb2__SOS_-_r32
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1240
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1241
participant stoichiometry: PARTICIPANT STOICHIOMETRY r32 1242
left: FGFR1-4
left: Complex (Grb2/SOS)
interaction type: HETERODIMER_ASSOCIATION
right: Complex (FGFR1-4/Grb2/ SOS)

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot P21708 334
xref: PTHR24055:SF393
organism: Rattus norvegicus

PARTICIPANT STOICHIOMETRY r19 1249
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 1248
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot P47809 834
organism: Mus musculus

uniprot Q06967 233
type: UnificationXref
id: Q06967
db: uniprot

uniprot C9J798 1093
type: UnificationXref
id: C9J798
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
controller: Ras

ncbitaxon 9606 69
type: UnificationXref
id: 9606
db: ncbitaxon

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A2VDZ0 409
xref: PTHR10257:SF6
organism: Bos taurus

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
type: ProteinReference
xref: uniprot O00750 909
xref: PTHR10048:SF30
organism: Homo sapiens

GTPase-activating protein
type: ProteinReference
xref: PTHR10194:SF126
xref: uniprot P48423 1104
organism: Drosophila melanogaster

14-3-3 protein homolog
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot O42766 189
organism: Candida albicans

uniprot A0A0G2K210 785
type: UnificationXref
id: A0A0G2K210
db: uniprot

uniprot Q5PRD0 246
type: UnificationXref
id: Q5PRD0
db: uniprot

uniprot E2QVP6 154
type: UnificationXref
id: E2QVP6
db: uniprot

uniprot C3XQF4 431
type: UnificationXref
id: C3XQF4
db: uniprot

Fibroblast growth factor 5
type: ProteinReference
xref: PTHR11486:SF23
xref: uniprot P48807 99
organism: Rattus norvegicus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O00329 907
xref: PTHR10048:SF35
organism: Homo sapiens

uniprot F5HEA9 323
type: UnificationXref
id: F5HEA9
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot E2QVP6 154
organism: Canis lupus familiaris

PTHR24070:SF251
type: RelationshipXref
id: PTHR24070:SF251
db: PANTHER Family
relationship type: By Homology

Danio rerio
type: BioSource
xref: ncbitaxon 7955 29

Complex (Grb2/SOS)
type: Complex
component stoichiometry: Grb2 s5 sa4 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s6 sa5 STOICHIOMETRY ID COMPLEX
component: Grb2
component: SOS
feature: COMPLEX BINDING FEATURE s66 a78 1224
feature: COMPLEX BINDING FEATURE s66 a78 1222
cellular location: cytoplasm

uniprot H2QKD0 847
type: UnificationXref
id: H2QKD0
db: uniprot

RasGAP
type: ProteinReference
xref: P00646
standard name: Ras GTPase-Activating Protein
comment: ENTITY_REFERENCE_NOTES= Long Name: p120 Ras GTPase-activating protein Synonym: Synonym not specified Accession: P00646
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.RasGAP
member entity reference: RAS p21 protein activator 2
member entity reference: RAS p21 protein activator (GTPase activating protein) 1
member entity reference: Uncharacterized protein
member entity reference: RasGAP-activating-like protein 1
member entity reference: Ras GTPase-activating protein 4B
member entity reference: RAS p21 protein activator 1
member entity reference: AGAP002729-PA
member entity reference: Ras GTPase-activating protein 1
member entity reference: GH13542p
member entity reference: Ras GTPase-activating protein 2
member entity reference: GTPase-activating protein
member entity reference: Ras GTPase-activating protein 4

PARTICIPANT STOICHIOMETRY r19 1251
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r19 1250
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

ncbitaxon 9598 11
type: UnificationXref
id: 9598
db: ncbitaxon

uniprot Q04589 814
type: UnificationXref
id: Q04589
db: uniprot

Protein kinase C, eye isozyme
type: ProteinReference
xref: uniprot P13677 1161
xref: PTHR24356:SF390
organism: Drosophila melanogaster

uniprot P29349 1120
type: UnificationXref
id: P29349
db: uniprot

uniprot F7BWW9 946
type: UnificationXref
id: F7BWW9
db: uniprot

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot Q63538 1027
organism: Rattus norvegicus

uniprot P28867 1168
type: UnificationXref
id: P28867
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7AKA6 747
xref: PTHR48016:SF32
organism: Monodelphis domestica

Mitogen-activated protein kinase kinase kinase 3 isoform 1
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot A0A1D5QJ66 733
organism: Macaca mulatta

uniprot F7F0I1 46
type: UnificationXref
id: F7F0I1
db: uniprot

Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
type: ProteinReference
xref: uniprot Q0E2P1 530
organism: Oryza sativa

uniprot Q68Y52 1076
type: UnificationXref
id: Q68Y52
db: uniprot

uniprot F7D846 43
type: UnificationXref
id: F7D846
db: uniprot

MKK4,7
type: ProteinReference
xref: P00637
standard name: Dual specificity mitogen-activated protein kinase kinase 4 and 7
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.MKK4,7
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Dual specificity mitogen-activated protein kinase kinase 4 and 7 Synonym: MAP kinase kinase 4 and 7,MAPK/ERK kinase 4 and 7,MAPKK 4 and 7 Accession: P00637
member entity reference: Mitogen-activated protein kinase kinase 7
member entity reference: Dual specificity mitogen-activated protein kinase kinase hemipterous
member entity reference: Uncharacterized protein
member entity reference: Dual specificity mitogen-activated protein kinase kinase 7
member entity reference: Dual specificity mitogen-activated protein kinase kinase 4
member entity reference: MAP kinase kinase 4, isoform A
member entity reference: MAP2K4 isoform 3
member entity reference: Mitogen-activated protein kinase kinase 4A
member entity reference: Mitogen-activated protein kinase kinase 4
member entity reference: MAP2K4 protein

Fibroblast growth factor 16
type: ProteinReference
xref: PTHR11486:SF27
xref: uniprot O54769 72
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
type: ProteinReference
xref: uniprot Q8BG02 585
xref: PTHR11871:SF5
organism: Mus musculus

uniprot A8X180 615
type: UnificationXref
id: A8X180
db: uniprot

uniprot O76932 492
type: UnificationXref
id: O76932
db: uniprot

uniprot Q6PD28 569
type: UnificationXref
id: Q6PD28
db: uniprot

uniprot Q5CZQ1 241
type: UnificationXref
id: Q5CZQ1
db: uniprot

Ustilago maydis
type: BioSource
xref: ncbitaxon 237631 136

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot D4A5Q1 881
xref: PTHR10048:SF35
organism: Rattus norvegicus

GRB2-related adapter protein
type: ProteinReference
xref: uniprot F7GJG7 649
xref: PTHR46037:SF2
organism: Macaca mulatta

uniprot F1PKW7 162
type: UnificationXref
id: F1PKW7
db: uniprot

uniprot D4A5Q1 881
type: UnificationXref
id: D4A5Q1
db: uniprot

uniprot Q27884 544
type: UnificationXref
id: Q27884
db: uniprot

PTHR24416:SF343
type: RelationshipXref
id: PTHR24416:SF343
db: PANTHER Family
relationship type: By Homology

uniprot P42657 208
type: UnificationXref
id: P42657
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0D1C4Y4 313
xref: PTHR24055:SF158
organism: Ustilago maydis

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot F6WVD2 1115
xref: PTHR46559:SF1
organism: Monodelphis domestica

14-3-3-like protein GF14-C
type: ProteinReference
xref: uniprot Q6ZKC0 257
xref: PTHR18860:SF109
organism: Oryza sativa

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A2I3TRY9 874
xref: PTHR10048:SF7
organism: Pan troglodytes

uniprot A5D992 290
type: UnificationXref
id: A5D992
db: uniprot

uniprot H2QQ50 300
type: UnificationXref
id: H2QQ50
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF21
xref: uniprot F1N795 1096
organism: Bos taurus

Protein enhancer of sevenless 2B
type: ProteinReference
xref: PTHR46037:SF1
xref: uniprot Q08012 651
organism: Drosophila melanogaster

uniprot F6ZKB3 373
type: UnificationXref
id: F6ZKB3
db: uniprot

uniprot P20444 1164
type: UnificationXref
id: P20444
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot Q4KSH7 836
organism: Rattus norvegicus

Mitogen-activated protein kinase 5
type: ProteinReference
xref: uniprot Q10N20 341
organism: Oryza sativa

uniprot P62258 217
type: UnificationXref
id: P62258
db: uniprot

uniprot Q20655 236
type: UnificationXref
id: Q20655
db: uniprot

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot P35213 201
xref: PTHR18860:SF28
organism: Rattus norvegicus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6XP81 671
organism: Xenopus tropicalis

Mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: PTHR48013:SF21
xref: uniprot F6PXH5 275
organism: Ornithorhynchus anatinus

Fibroblast growth factor 9
type: ProteinReference
xref: uniprot P36364 93
organism: Rattus norvegicus

Fibroblast growth factor 7
type: ProteinReference
xref: PTHR11486:SF20
xref: uniprot P36363 92
organism: Mus musculus

Protein sprouty homolog 4
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot A2VDU1 289
organism: Bos taurus

uniprot A9SI18 422
type: UnificationXref
id: A9SI18
db: uniprot

ncbitaxon 5786 439
type: UnificationXref
id: 5786
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F7FRT9 181
organism: Monodelphis domestica

ncbitaxon 3218 423
type: UnificationXref
id: 3218
db: ncbitaxon

Ras-like protein rasG
type: ProteinReference
xref: uniprot P15064 716
xref: PTHR24070:SF17
organism: Dictyostelium discoideum

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform
type: ProteinReference
xref: PTHR10257:SF3
xref: uniprot Q10428 533
organism: Schizosaccharomyces pombe

p38
type: Protein
entity reference: p38
feature: p38 s53 a66 rs2
feature: p38 s53 a66 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Stress-activated protein kinase JNK
type: ProteinReference
xref: uniprot P92208 385
organism: Drosophila melanogaster

uniprot P55075 101
type: UnificationXref
id: P55075
db: uniprot

MEKK1-5
type: Protein
entity reference: MEKK1-5
feature: ACTIVE 287
feature: MEKK1 5 s49 a61 rs1
feature: MEKK1 5 s49 a61 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 8364 17
type: UnificationXref
id: 8364
db: ncbitaxon

uniprot F7E5M4 472
type: UnificationXref
id: F7E5M4
db: uniprot

PTHR10048:SF64
type: RelationshipXref
id: PTHR10048:SF64
db: PANTHER Family
relationship type: By Homology

uniprot Q02384 951
type: UnificationXref
id: Q02384
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZKJ2 250
xref: PTHR18860:SF16
organism: Gallus gallus

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 54

uniprot F6NSV0 28
type: UnificationXref
id: F6NSV0
db: uniprot

uniprot F7E2C0 471
type: UnificationXref
id: F7E2C0
db: uniprot

Grb2 s35 sa13 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

uniprot P54674 923
type: UnificationXref
id: P54674
db: uniprot

uniprot Q380U3 1069
type: UnificationXref
id: Q380U3
db: uniprot

uniprot H9FU32 992
type: UnificationXref
id: H9FU32
db: uniprot

uniprot F1LSG7 794
type: UnificationXref
id: F1LSG7
db: uniprot

Serine/threonine-protein phosphatase PP2A-4 catalytic subunit
type: ProteinReference
xref: uniprot A3C4N5 410
organism: Oryza sativa

uniprot Q80W83 583
type: UnificationXref
id: Q80W83
db: uniprot

PHYSICAL_STIMULATION
type: RelationshipTypeVocabulary

uniprot Q16537 541
type: UnificationXref
id: Q16537
db: uniprot

uniprot F6PXH5 275
type: UnificationXref
id: F6PXH5
db: uniprot

INHIBITION
type: RelationshipTypeVocabulary

uniprot A7RFC7 415
type: UnificationXref
id: A7RFC7
db: uniprot

uniprot F7FZS3 802
type: UnificationXref
id: F7FZS3
db: uniprot

ACTIVE 287
type: EntityFeature
comment: Active state

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot E1BWA3 1135
organism: Gallus gallus

PI3K s17 sa9 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PI3K
stoichiometric coefficient: 1.0

uniprot P21804 810
type: UnificationXref
id: P21804
db: uniprot

Protein CBR-SEM-5
type: ProteinReference
xref: uniprot A8XPY6 648
xref: PTHR46037:SF1
organism: Caenorhabditis briggsae

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q8I2Q4 586
organism: Plasmodium falciparum

uniprot P28482 337
type: UnificationXref
id: P28482
db: uniprot

PTHR45619:SF6
type: RelationshipXref
id: PTHR45619:SF6
db: PANTHER Family
relationship type: By Homology

Tyrosine-protein phosphatase non-receptor type 11
type: ProteinReference
xref: uniprot P35235 1123
xref: PTHR46559:SF1
organism: Mus musculus

uniprot P79996 384
type: UnificationXref
id: P79996
db: uniprot

uniprot Q38902 1070
type: UnificationXref
id: Q38902
db: uniprot

uniprot Q01525 232
type: UnificationXref
id: Q01525
db: uniprot

Fibroblast growth factor 10
type: ProteinReference
xref: uniprot O15520 68
xref: PTHR11486:SF21
organism: Homo sapiens

uniprot Q84UI5 355
type: UnificationXref
id: Q84UI5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F301 48
organism: Macaca mulatta

PTHR10048:SF34
type: RelationshipXref
id: PTHR10048:SF34
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF33
type: RelationshipXref
id: PTHR10048:SF33
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF4
xref: uniprot A0A3Q1MK31 1092
organism: Bos taurus

PTHR10048:SF35
type: RelationshipXref
id: PTHR10048:SF35
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F7HLC7 901
xref: PTHR10048:SF35
organism: Macaca mulatta

STATE_TRANSITION_LEFT__JNK1_3-RIGHT__JNK1_3-_r24
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1279
participant stoichiometry: PARTICIPANT STOICHIOMETRY r24 1278
left: JNK1-3
interaction type: STATE_TRANSITION
right: JNK1-3

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r4
controller: Complex (FGFR1-4/PLC_gamma/ RasGAP/PI3K/ FRS2/SHP2/ SHC/Grb2/ SOS)

LD28067p
type: ProteinReference
xref: PTHR10048:SF64
xref: uniprot Q7K3H0 929
organism: Drosophila melanogaster

Fibroblast growth factor 8
type: ProteinReference
xref: uniprot O57341 73
xref: PTHR11486:SF3
organism: Danio rerio

Uncharacterized protein
type: ProteinReference
xref: uniprot Q86H88 631
organism: Dictyostelium discoideum

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
type: ProteinReference
xref: uniprot Q15173 540
xref: PTHR10257:SF4
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
type: ProteinReference
xref: uniprot Q15172 539
xref: PTHR10257:SF6
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot A0A2I3RQJ8 1128
organism: Pan troglodytes

uniprot P45983 379
type: UnificationXref
id: P45983
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot A0A3Q1LQK4 876
xref: PTHR10048:SF7
organism: Bos taurus

uniprot O42376 1017
type: UnificationXref
id: O42376
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot G3X7B5 673
xref: PTHR24351:SF200
organism: Bos taurus

uniprot F7DY09 44
type: UnificationXref
id: F7DY09
db: uniprot

uniprot Q9M1Z5 359
type: UnificationXref
id: Q9M1Z5
db: uniprot

uniprot P63331 519
type: UnificationXref
id: P63331
db: uniprot

PTHR10048:SF48
type: RelationshipXref
id: PTHR10048:SF48
db: PANTHER Family
relationship type: By Homology

uniprot Q6ZKC0 257
type: UnificationXref
id: Q6ZKC0
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7CP86 468
xref: PTHR45619:SF44
organism: Monodelphis domestica

Protein sprouty homolog 2
type: ProteinReference
xref: uniprot Q9PTL2 309
xref: PTHR12365:SF8
organism: Gallus gallus

uniprot P70618 1022
type: UnificationXref
id: P70618
db: uniprot

PTHR48016:SF32
type: RelationshipXref
id: PTHR48016:SF32
db: PANTHER Family
relationship type: By Homology

uniprot Q4QQT4 551
type: UnificationXref
id: Q4QQT4
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot A2BG80 408
xref: PTHR11871:SF2
organism: Danio rerio

Dictyostelium purpureum
type: BioSource
xref: ncbitaxon 5786 439

uniprot Q02156 1179
type: UnificationXref
id: Q02156
db: uniprot

uniprot P63103 223
type: UnificationXref
id: P63103
db: uniprot

-Ha-ras Harvey rat sarcoma viral oncogene homolog, like
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q503B6 726
organism: Danio rerio

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot E2R7W7 273
organism: Canis lupus familiaris

PTHR10048:SF14
type: RelationshipXref
id: PTHR10048:SF14
db: PANTHER Family
relationship type: By Homology

uniprot F6WV79 371
type: UnificationXref
id: F6WV79
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F7BS95 176
organism: Monodelphis domestica

uniprot Q9CX99 658
type: UnificationXref
id: Q9CX99
db: uniprot

uniprot P61329 106
type: UnificationXref
id: P61329
db: uniprot

uniprot F7A522 464
type: UnificationXref
id: F7A522
db: uniprot

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: uniprot I0FRT6 754
xref: PTHR11584:SF332
organism: Macaca mulatta

uniprot F6R8N3 669
type: UnificationXref
id: F6R8N3
db: uniprot

uniprot J9P6N4 188
type: UnificationXref
id: J9P6N4
db: uniprot

uniprot Q22070 852
type: UnificationXref
id: Q22070
db: uniprot

…
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 2.0

uniprot Q7JWS8 1084
type: UnificationXref
id: Q7JWS8
db: uniprot

uniprot A0A2I3RG08 856
type: UnificationXref
id: A0A2I3RG08
db: uniprot

Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit
type: ProteinReference
xref: uniprot P23636 497
organism: Schizosaccharomyces pombe

Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit
type: ProteinReference
xref: uniprot P23635 496
organism: Schizosaccharomyces pombe

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
type: ProteinReference
xref: uniprot J9P6N4 188
xref: PTHR18860:SF16
organism: Canis lupus familiaris

Rac family small GTPase 3b
type: ProteinReference
xref: uniprot A9JRY8 1037
xref: PTHR24072:SF301
organism: Danio rerio

uniprot E2R186 793
type: UnificationXref
id: E2R186
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11584:SF332
xref: uniprot F1MXH6 742
organism: Bos taurus

cytoplasm
type: CellularLocationVocabulary
xref: GO GO:0005737 2

uniprot Q0P594 531
type: UnificationXref
id: Q0P594
db: uniprot

PTHR10048:SF29
type: RelationshipXref
id: PTHR10048:SF29
db: PANTHER Family
relationship type: By Homology

uniprot A0A2I3TP74 405
type: UnificationXref
id: A0A2I3TP74
db: uniprot

PTHR10048:SF28
type: RelationshipXref
id: PTHR10048:SF28
db: PANTHER Family
relationship type: By Homology

PTHR23113:SF341
type: RelationshipXref
id: PTHR23113:SF341
db: PANTHER Family
relationship type: By Homology

uniprot P46734 281
type: UnificationXref
id: P46734
db: uniprot

uniprot A0A0P0V857 614
type: UnificationXref
id: A0A0P0V857
db: uniprot

uniprot Q7ZVK8 354
type: UnificationXref
id: Q7ZVK8
db: uniprot

uniprot A0A1D5QJ66 733
type: UnificationXref
id: A0A1D5QJ66
db: uniprot

uniprot Q9SSX0 1087
type: UnificationXref
id: Q9SSX0
db: uniprot

PTHR10048:SF30
type: RelationshipXref
id: PTHR10048:SF30
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor 7
type: ProteinReference
xref: uniprot P21781 90
organism: Homo sapiens

STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r21
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1226
participant stoichiometry: PARTICIPANT STOICHIOMETRY r21 1227
left: Rac
interaction type: STATE_TRANSITION
right: Rac

uniprot Q7QEJ7 931
type: UnificationXref
id: Q7QEJ7
db: uniprot

14-3-3 protein 2
type: ProteinReference
xref: uniprot C4LXB1 150
xref: PTHR18860:SF106
organism: Entamoeba histolytica

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: PTHR10336:SF173
xref: uniprot A0A1D5R8E9 839
organism: Macaca mulatta

ARTA
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q5B4M9 239
organism: Emericella nidulans

uniprot Q7PRZ7 285
type: UnificationXref
id: Q7PRZ7
db: uniprot

Protein CBR-PAR-5
type: ProteinReference
xref: uniprot A8X0R4 143
xref: PTHR18860:SF21
organism: Caenorhabditis briggsae

Uncharacterized protein
type: ProteinReference
xref: uniprot F7GLY8 279
xref: PTHR48013:SF21
organism: Macaca mulatta

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70167 911
organism: Mus musculus

ERK1-2
type: Protein
entity reference: ERK1-2
feature: ERK1 2 s27 a30 rs2
feature: ERK1 2 s27 a30 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s35 sa13 1219
feature: ACTIVE 287
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Alpha isoform of regulatory subunit A, protein phosphatase 2
type: ProteinReference
xref: PTHR10648:SF2
xref: uniprot A5D973 412
organism: Bos taurus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot W4ZAK5 612
xref: PTHR45619:SF12
organism: Strongylocentrotus purpuratus

uniprot F7F3S0 897
type: UnificationXref
id: F7F3S0
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q63932 979
organism: Mus musculus

uniprot G5EDY0 902
type: UnificationXref
id: G5EDY0
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F6TAH0 845
xref: PTHR10336:SF173
organism: Monodelphis domestica

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A0G2JZD1 392
xref: PTHR10257:SF19
organism: Rattus norvegicus

uniprot P22543 914
type: UnificationXref
id: P22543
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot F6ZB49 41
xref: PTHR11486:SF28
organism: Xenopus tropicalis

uniprot C4M5T0 1041
type: UnificationXref
id: C4M5T0
db: uniprot

uniprot K7BV01 484
type: UnificationXref
id: K7BV01
db: uniprot

Rac
type: ProteinReference
xref: P00645
standard name: Ras-related C3 botulinum toxin substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.Rac
comment: ENTITY_REFERENCE_NOTES= Long Name: Rac Synonym: Synonym not specified Accession: P00645
member entity reference: Ras-related protein ced-10
member entity reference: Ras-related C3 botulinum toxin substrate 2
member entity reference: Rho-related protein rac1B
member entity reference: Rac-like GTP-binding protein ARAC7
member entity reference: Ras-related C3 botulinum toxin substrate 1
member entity reference: Rac family small GTPase 1b
member entity reference: AGAP001573-PA
member entity reference: Rac family small GTPase 3a
member entity reference: Uncharacterized protein
member entity reference: Protein CBR-MIG-2
member entity reference: Uncharacterized protein racC
member entity reference: Rac-like GTP-binding protein ARAC2
member entity reference: Rac-like GTP-binding protein 2
member entity reference: Rac-like GTP-binding protein 5
member entity reference: Rac-like GTP-binding protein ARAC11
member entity reference: Rac-like GTPase
member entity reference: Rho family GTPase
member entity reference: Rac1B, RHO family GTPase
member entity reference: Rho-related protein racC
member entity reference: Rac family small GTPase 1
member entity reference: Ras-related protein rac-2
member entity reference: Rac-like GTP-binding protein ARAC9
member entity reference: Rop-family small GTPase
member entity reference: Rac-like GTP-binding protein ARAC1
member entity reference: GTPase cRac1A
member entity reference: Rac-like GTP-binding protein 6
member entity reference: Rac-like GTP-binding protein ARAC4
member entity reference: Rac-like GTP-binding protein ARAC3
member entity reference: AT17867p
member entity reference: Ras-related protein Rac1
member entity reference: Ras-related protein Rac2
member entity reference: Rac-like GTP-binding protein 1
member entity reference: Cell division control protein 42 homolog
member entity reference: Rho-related protein racA
member entity reference: Rho-related protein rac1C
member entity reference: Rac family small GTPase 3b
member entity reference: Rho-related protein racB
member entity reference: Rho-related protein rac1A
member entity reference: Rac family small GTPase 3
member entity reference: Uncharacterized protein rac1A
member entity reference: Rac-like GTP-binding protein 7
member entity reference: Rac-like GTP-binding protein 4
member entity reference: Rac family small GTPase 1a
member entity reference: Rac family small GTPase 2

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
type: ProteinReference
xref: PTHR10048:SF29
xref: uniprot O70173 912
organism: Rattus norvegicus

uniprot P39745 338
type: UnificationXref
id: P39745
db: uniprot

uniprot P48580 512
type: UnificationXref
id: P48580
db: uniprot

uniprot P22126 717
type: UnificationXref
id: P22126
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot F6RCU6 670
organism: Macaca mulatta

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P62260 219
organism: Rattus norvegicus

Fibroblast growth factor
type: ProteinReference
xref: uniprot H2QNZ3 60
xref: PTHR11486:SF17
organism: Pan troglodytes

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P62261 220
organism: Bos taurus

uniprot A0A1D5R6N7 398
type: UnificationXref
id: A0A1D5R6N7
db: uniprot

uniprot P27638 336
type: UnificationXref
id: P27638
db: uniprot

uniprot O60258 74
type: UnificationXref
id: O60258
db: uniprot

ncbitaxon 5759 151
type: UnificationXref
id: 5759
db: ncbitaxon

GO GO:0005737 2
type: UnificationXref
id: GO:0005737
db: GO

uniprot P98083 862
type: UnificationXref
id: P98083
db: uniprot

Mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot A0A2I3SB47 824
organism: Pan troglodytes

uniprot K7BYT0 966
type: UnificationXref
id: K7BYT0
db: uniprot

Tyrosine-protein phosphatase non-receptor type 11
type: ProteinReference
xref: PTHR46559:SF1
xref: uniprot P41499 1124
organism: Rattus norvegicus

uniprot F0ZSC4 443
type: UnificationXref
id: F0ZSC4
db: uniprot

uniprot P70379 112
type: UnificationXref
id: P70379
db: uniprot

uniprot A2BG80 408
type: UnificationXref
id: A2BG80
db: uniprot

uniprot Q9XT09 981
type: UnificationXref
id: Q9XT09
db: uniprot

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P62259 218
organism: Mus musculus

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot P62258 217
xref: PTHR18860:SF67
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42336 916
xref: PTHR10048:SF107
organism: Homo sapiens

Ras-related protein rac-2
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot Q94124 1086
organism: Caenorhabditis elegans

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P42338 918
xref: PTHR10048:SF33
organism: Homo sapiens

Phosphatidylinositol 3-kinase age-1
type: ProteinReference
xref: PTHR10048:SF14
xref: uniprot Q94125 934
organism: Caenorhabditis elegans

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P42337 917
xref: PTHR10048:SF107
organism: Mus musculus

Mitogen-activated protein kinase pmk-1
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot Q17446 1025
organism: Caenorhabditis elegans

Phosphatidylinositol 3-kinase VPS34
type: ProteinReference
xref: uniprot P42339 919
xref: PTHR10048:SF7
organism: Arabidopsis thaliana

Protein CBR-MEK-2
type: ProteinReference
xref: PTHR48013:SF19
xref: uniprot A8WWD7 961
organism: Caenorhabditis briggsae

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q02956 1180
organism: Mus musculus

Spry
type: Protein
entity reference: Spry
feature: Spry s14 a13 rs1
feature: ACTIVE 287
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot Q7S7P2 577
organism: Neurospora crassa

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot F1P859 941
xref: PTHR23113:SF150
organism: Canis lupus familiaris

uniprot D3ZVF3 880
type: UnificationXref
id: D3ZVF3
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q6PF93 928
organism: Mus musculus

uniprot P08620 80
type: UnificationXref
id: P08620
db: uniprot

uniprot P41743 1173
type: UnificationXref
id: P41743
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: uniprot Q64617 1189
xref: PTHR24356:SF192
organism: Rattus norvegicus

uniprot Q9HCT0 130
type: UnificationXref
id: Q9HCT0
db: uniprot

uniprot F6XLR8 172
type: UnificationXref
id: F6XLR8
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r4
control type: INHIBITION
controller: Grb2

uniprot F6YAB9 1011
type: UnificationXref
id: F6YAB9
db: uniprot

uniprot Q99759 765
type: UnificationXref
id: Q99759
db: uniprot

uniprot Q05144 1067
type: UnificationXref
id: Q05144
db: uniprot

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot Q95ME4 731
organism: Monodelphis domestica

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63318 1174
organism: Mus musculus

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P63319 1175
organism: Rattus norvegicus

uniprot Q00005 523
type: UnificationXref
id: Q00005
db: uniprot

uniprot Q498D6 816
type: UnificationXref
id: Q498D6
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot F6W7C8 893
organism: Macaca mulatta

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P63331 519
xref: PTHR45619:SF42
organism: Rattus norvegicus

uniprot P34885 1170
type: UnificationXref
id: P34885
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: PTHR10257:SF3
xref: uniprot A9UJN4 426
organism: Caenorhabditis elegans

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P63330 518
xref: PTHR45619:SF42
organism: Mus musculus

uniprot F7DUD6 896
type: UnificationXref
id: F7DUD6
db: uniprot

PTHR24361:SF414
type: RelationshipXref
id: PTHR24361:SF414
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r6 1264
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot Q0TVB5 532
type: UnificationXref
id: Q0TVB5
db: uniprot

PARTICIPANT STOICHIOMETRY r6 1265
type: Stoichiometry
physical entity: PKC
stoichiometric coefficient: 1.0

uniprot P40792 1060
type: UnificationXref
id: P40792
db: uniprot

uniprot P13109 85
type: UnificationXref
id: P13109
db: uniprot

uniprot Q8VI79 121
type: UnificationXref
id: Q8VI79
db: uniprot

uniprot Q5XI34 557
type: UnificationXref
id: Q5XI34
db: uniprot

uniprot B7UCP9 18
type: UnificationXref
id: B7UCP9
db: uniprot

FRS2
type: ProteinReference
xref: P00635
standard name: fibroblast growth factor receptor substrate
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: fibroblast growth factor receptor substrate Synonym: suc1-associated neurotrophic factor target Accession: P00635
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.FRS2
member entity reference: Fibroblast growth factor receptor substrate 2
member entity reference: Uncharacterized protein
member entity reference: FRS3 isoform 1
member entity reference: Fibroblast growth factor receptor substrate 3
member entity reference: FRS3 protein

uniprot Q86H88 631
type: UnificationXref
id: Q86H88
db: uniprot

uniprot C4M5Q7 1040
type: UnificationXref
id: C4M5Q7
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q61831 386
xref: PTHR24055:SF162
organism: Mus musculus

uniprot F1PBB6 827
type: UnificationXref
id: F1PBB6
db: uniprot

PTHR10194:SF126
type: RelationshipXref
id: PTHR10194:SF126
db: PANTHER Family
relationship type: By Homology

eco ECO:0000316 5
type: UnificationXref
id: ECO:0000316
db: eco

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot D3ZDI7 434
xref: PTHR10257:SF6
organism: Rattus norvegicus

uniprot B3S653 427
type: UnificationXref
id: B3S653
db: uniprot

uniprot F6V7D9 459
type: UnificationXref
id: F6V7D9
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot E1C5A3 435
xref: PTHR10257:SF6
organism: Gallus gallus

uniprot A0A2I3SED2 1091
type: UnificationXref
id: A0A2I3SED2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BBM1 895
xref: PTHR10048:SF30
organism: Monodelphis domestica

Fibroblast growth factor 7
type: ProteinReference
xref: uniprot Q02195 115
xref: PTHR11486:SF20
organism: Rattus norvegicus

uniprot O70167 911
type: UnificationXref
id: O70167
db: uniprot

uniprot A9JRY8 1037
type: UnificationXref
id: A9JRY8
db: uniprot

uniprot P61148 102
type: UnificationXref
id: P61148
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q9XT09 981
organism: Pan troglodytes

uniprot Q7PWN1 630
type: UnificationXref
id: Q7PWN1
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
control type: INHIBITION
controller: Akt

uniprot D3ZDI7 434
type: UnificationXref
id: D3ZDI7
db: uniprot

Grb2
type: Protein
entity reference: Grb2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F4I1B7 163
type: UnificationXref
id: F4I1B7
db: uniprot

uniprot Q03206 1066
type: UnificationXref
id: Q03206
db: uniprot

uniprot P29311 196
type: UnificationXref
id: P29311
db: uniprot

uniprot F1MG56 445
type: UnificationXref
id: F1MG56
db: uniprot

uniprot K7ALD7 705
type: UnificationXref
id: K7ALD7
db: uniprot

uniprot P34148 1058
type: UnificationXref
id: P34148
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F6XW91 173
organism: Ornithorhynchus anatinus

PTHR11486:SF4
type: RelationshipXref
id: PTHR11486:SF4
db: PANTHER Family
relationship type: By Homology

AGAP011036-PA (Fragment)
type: ProteinReference
xref: PTHR10048:SF64
xref: uniprot A0NBA9 877
organism: Anopheles gambiae

uniprot F7BVQ1 846
type: UnificationXref
id: F7BVQ1
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF27
xref: uniprot F1MHC6 25
organism: Bos taurus

PTHR11486:SF3
type: RelationshipXref
id: PTHR11486:SF3
db: PANTHER Family
relationship type: By Homology

Serine/threonine protein phosphatase 2A regulatory subunit B''alpha
type: ProteinReference
xref: uniprot Q9XGR4 604
organism: Arabidopsis thaliana

uniprot D3ZFL3 737
type: UnificationXref
id: D3ZFL3
db: uniprot

uniprot F6S9S9 963
type: UnificationXref
id: F6S9S9
db: uniprot

uniprot A0A2I3TDL0 404
type: UnificationXref
id: A0A2I3TDL0
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot A0A3Q1LSJ2 735
organism: Bos taurus

uniprot Q10N20 341
type: UnificationXref
id: Q10N20
db: uniprot

uniprot P0CY33 1052
type: UnificationXref
id: P0CY33
db: uniprot

uniprot P14681 332
type: UnificationXref
id: P14681
db: uniprot

Stratifin
type: ProteinReference
xref: PTHR18860:SF14
xref: uniprot F7BU66 177
organism: Ornithorhynchus anatinus

uniprot Q7PQ61 574
type: UnificationXref
id: Q7PQ61
db: uniprot

uniprot Q9CQV8 267
type: UnificationXref
id: Q9CQV8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF3
xref: uniprot F6Y478 174
organism: Canis lupus familiaris

Fibroblast growth factor receptor 3
type: ProteinReference
xref: PTHR24416:SF505
xref: uniprot Q61851 817
organism: Mus musculus

Protein phosphatase PP2A regulatory subunit B
type: ProteinReference
xref: uniprot V5IPN6 611
xref: PTHR11871:SF0
organism: Neurospora crassa

MKK3,6
type: Protein
entity reference: MKK3,6
feature: MKK3,6 s51 a64 rs1
feature: MKK3,6 s51 a64 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q9FXT7 356
organism: Chlamydomonas reinhardtii

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: PTHR46257:SF1
xref: uniprot A0A2R8QL35 1111
organism: Danio rerio

SHC-transforming protein 3
type: ProteinReference
xref: uniprot O70143 860
xref: PTHR10337:SF4
organism: Rattus norvegicus

uniprot Q9QXV9 311
type: UnificationXref
id: Q9QXV9
db: uniprot

Fibroblast growth factor 20
type: ProteinReference
xref: uniprot Q9EST9 129
xref: PTHR11486:SF72
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1260
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 1261
left: Akt
interaction type: STATE_TRANSITION
right: Akt

uniprot F6URW3 944
type: UnificationXref
id: F6URW3
db: uniprot

uniprot P0CQ42 715
type: UnificationXref
id: P0CQ42
db: uniprot

Protein sprouty homolog 1
type: ProteinReference
xref: uniprot A5D992 290
xref: PTHR12365:SF10
organism: Bos taurus

14-3-3
type: Protein
entity reference: 14-3-3
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q8RZZ3 589
type: UnificationXref
id: Q8RZZ3
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot Q14738 538
organism: Homo sapiens

uniprot F6WVD2 1115
type: UnificationXref
id: F6WVD2
db: uniprot

ncbitaxon 559292 197
type: UnificationXref
id: 559292
db: ncbitaxon

FGF
type: Protein
entity reference: FGF
comment: SPECIES_TYPE=PROTEIN

uniprot A7Z057 140
type: UnificationXref
id: A7Z057
db: uniprot

PTHR10648:SF2
type: RelationshipXref
id: PTHR10648:SF2
db: PANTHER Family
relationship type: By Homology

uniprot P61150 104
type: UnificationXref
id: P61150
db: uniprot

MAP2K1 protein
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q0VD16 972
organism: Bos taurus

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot J9P5W6 965
xref: PTHR48013:SF5
organism: Canis lupus familiaris

Fibroblast growth factor 4
type: ProteinReference
xref: uniprot P11403 82
organism: Mus musculus

uniprot P36363 92
type: UnificationXref
id: P36363
db: uniprot

uniprot Q0E2P1 530
type: UnificationXref
id: Q0E2P1
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F6QUW1 943
xref: PTHR23113:SF168
organism: Monodelphis domestica

uniprot Q07098 525
type: UnificationXref
id: Q07098
db: uniprot

uniprot A0A1D5QUZ8 315
type: UnificationXref
id: A0A1D5QUZ8
db: uniprot

uniprot G3X7B5 673
type: UnificationXref
id: G3X7B5
db: uniprot

Fibroblast growth factor 5
type: ProteinReference
xref: uniprot A0MTF4 14
organism: Bos taurus

AGAP007643-PA
type: ProteinReference
xref: uniprot A0NBC2 138
xref: PTHR18860:SF106
organism: Anopheles gambiae

uniprot P05128 1155
type: UnificationXref
id: P05128
db: uniprot

uniprot A0A2I3TN31 771
type: UnificationXref
id: A0A2I3TN31
db: uniprot

uniprot A0A1D5QE27 871
type: UnificationXref
id: A0A1D5QE27
db: uniprot

uniprot P68511 230
type: UnificationXref
id: P68511
db: uniprot

Fibroblast growth factor 22
type: ProteinReference
xref: PTHR11486:SF41
xref: uniprot Q9ESS2 128
organism: Mus musculus

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9Y243 686
xref: PTHR24356:SF190
organism: Homo sapiens

uniprot Q24324 975
type: UnificationXref
id: Q24324
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11486:SF17
xref: uniprot F6QYV4 33
organism: Macaca mulatta

Serine/threonine-protein phosphatase 6 catalytic subunit
type: ProteinReference
xref: uniprot Q9U9A3 601
organism: Dictyostelium discoideum

MAP2K2 isoform 1
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot K7BYT0 966
organism: Pan troglodytes

Fibroblast growth factor
type: ProteinReference
xref: uniprot F6SHQ2 37
organism: Monodelphis domestica

GRB2-related adapter protein
type: ProteinReference
xref: PTHR46037:SF2
xref: uniprot Q9CX99 658
organism: Mus musculus

uniprot P14056 1000
type: UnificationXref
id: P14056
db: uniprot

uniprot P11362 804
type: UnificationXref
id: P11362
db: uniprot

uniprot F1M9D0 740
type: UnificationXref
id: F1M9D0
db: uniprot

Fibroblast growth factor receptor substrate 3
type: ProteinReference
xref: uniprot O43559 781
organism: Homo sapiens

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot Q02156 1179
organism: Homo sapiens

uniprot Q7K3H0 929
type: UnificationXref
id: Q7K3H0
db: uniprot

uniprot C0H4V6 148
type: UnificationXref
id: C0H4V6
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot F7FDA0 898
organism: Monodelphis domestica

uniprot Q1K5B6 542
type: UnificationXref
id: Q1K5B6
db: uniprot

uniprot Q925E7 592
type: UnificationXref
id: Q925E7
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot P31938 967
organism: Mus musculus

PTHR24351:SF182
type: RelationshipXref
id: PTHR24351:SF182
db: PANTHER Family
relationship type: By Homology

uniprot P01119 708
type: UnificationXref
id: P01119
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot Q7PMF0 930
xref: PTHR10048:SF7
organism: Anopheles gambiae

uniprot F6V332 1010
type: UnificationXref
id: F6V332
db: uniprot

Rac-like GTP-binding protein ARAC9
type: ProteinReference
xref: uniprot Q9XGU0 1089
organism: Arabidopsis thaliana

14-3-3 protein 1
type: ProteinReference
xref: uniprot C4M323 153
xref: PTHR18860:SF106
organism: Entamoeba histolytica

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P24583 1166
xref: PTHR24356:SF390
organism: Saccharomyces cerevisiae

Fibroblast growth factor receptor
type: ProteinReference
xref: PTHR24416:SF130
xref: uniprot F1LSG7 794
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E1B8P9 320
xref: PTHR24055:SF393
organism: Bos taurus

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot P31946 198
xref: PTHR18860:SF28
organism: Homo sapiens

SHC s32 sa12 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SHC
stoichiometric coefficient: 1.0

14-3-3 protein sigma
type: ProteinReference
xref: PTHR18860:SF14
xref: uniprot P31947 199
organism: Homo sapiens

MEK1-2
type: Protein
entity reference: MEK1-2
feature: MEK1 2 s26 a29 rs1
feature: ACTIVE 287
feature: MEK1 2 s26 a29 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q925D6 286
type: UnificationXref
id: Q925D6
db: uniprot

ncbitaxon 7719 168
type: UnificationXref
id: 7719
db: ncbitaxon

uniprot A9JRC7 421
type: UnificationXref
id: A9JRC7
db: uniprot

uniprot A8XQR9 145
type: UnificationXref
id: A8XQR9
db: uniprot

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: uniprot K7CZM1 949
xref: PTHR23113:SF150
organism: Pan troglodytes

uniprot P63085 339
type: UnificationXref
id: P63085
db: uniprot

Ornithorhynchus anatinus
type: BioSource
xref: ncbitaxon 9258 35

ncbitaxon 367110 262
type: UnificationXref
id: 367110
db: ncbitaxon

14-3-3 family protein 7
type: ProteinReference
xref: uniprot Q7RVK6 261
xref: PTHR18860:SF17
organism: Neurospora crassa

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot Q28J96 815
xref: PTHR24416:SF131
organism: Xenopus tropicalis

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot P70236 283
organism: Mus musculus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62715 515
xref: PTHR45619:SF44
organism: Mus musculus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62716 516
xref: PTHR45619:SF44
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot P62714 514
xref: PTHR45619:SF44
organism: Homo sapiens

FGFR1-4
type: Protein
entity reference: FGFR1-4
feature: FGFR1 4 s84 a46 rs4
feature: FGFR1 4 s84 a46 rs1
feature: ACTIVE 287
feature: FGFR1 4 s84 a46 rs3
feature: FGFR1 4 s84 a46 rs2

uniprot P62259 218
type: UnificationXref
id: P62259
db: uniprot

Rac-like GTP-binding protein 5
type: ProteinReference
xref: uniprot Q6EP31 1078
organism: Oryza sativa

uniprot A2VDU1 289
type: UnificationXref
id: A2VDU1
db: uniprot

uniprot P19596 88
type: UnificationXref
id: P19596
db: uniprot

uniprot A7F3M0 316
type: UnificationXref
id: A7F3M0
db: uniprot

uniprot P31751 677
type: UnificationXref
id: P31751
db: uniprot

uniprot P34146 1056
type: UnificationXref
id: P34146
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7E823 325
xref: PTHR24055:SF203
organism: Monodelphis domestica

MAP2K4 protein
type: ProteinReference
xref: uniprot A5PJP8 825
xref: PTHR48013:SF15
organism: Bos taurus

uniprot A0A1D5R985 1127
type: UnificationXref
id: A0A1D5R985
db: uniprot

uniprot P05771 1158
type: UnificationXref
id: P05771
db: uniprot

uniprot A0A1D5PML4 3
type: UnificationXref
id: A0A1D5PML4
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot Q7PQ61 574
organism: Anopheles gambiae

Ras-related protein ced-10
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot Q03206 1066
organism: Caenorhabditis elegans

14-3-3 protein beta/alpha-A
type: ProteinReference
xref: uniprot Q5PRD0 246
xref: PTHR18860:SF28
organism: Danio rerio

uniprot Q4QQQ5 837
type: UnificationXref
id: Q4QQQ5
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot F1PX98 452
organism: Canis lupus familiaris

Fibroblast growth factor
type: ProteinReference
xref: uniprot E1BP37 20
xref: PTHR11486:SF72
organism: Bos taurus

PTHR11871:SF0
type: RelationshipXref
id: PTHR11871:SF0
db: PANTHER Family
relationship type: By Homology

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 22

PTHR11871:SF1
type: RelationshipXref
id: PTHR11871:SF1
db: PANTHER Family
relationship type: By Homology

Protein kinase C epsilon type
type: ProteinReference
xref: uniprot Q08BT6 1184
xref: PTHR24356:SF159
organism: Xenopus tropicalis

uniprot F6Z5N3 701
type: UnificationXref
id: F6Z5N3
db: uniprot

PTHR11871:SF2
type: RelationshipXref
id: PTHR11871:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q63932 979
type: UnificationXref
id: Q63932
db: uniprot

GTPase cRac1A
type: ProteinReference
xref: uniprot Q6LC82 1080
xref: PTHR24072:SF105
organism: Gallus gallus

uniprot Q6Z7L8 1082
type: UnificationXref
id: Q6Z7L8
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot H2QUT2 186
organism: Pan troglodytes

MEK1 2 s25 a28 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
type: ProteinReference
xref: uniprot Q66LE6 562
organism: Homo sapiens

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F1MAI3 939
organism: Rattus norvegicus

uniprot F7EJU0 278
type: UnificationXref
id: F7EJU0
db: uniprot

uniprot F7GEK1 672
type: UnificationXref
id: F7GEK1
db: uniprot

uniprot F7A632 1143
type: UnificationXref
id: F7A632
db: uniprot

PTHR11871:SF6
type: RelationshipXref
id: PTHR11871:SF6
db: PANTHER Family
relationship type: By Homology

PTHR11871:SF5
type: RelationshipXref
id: PTHR11871:SF5
db: PANTHER Family
relationship type: By Homology

uniprot Q9S9Z8 268
type: UnificationXref
id: Q9S9Z8
db: uniprot

uniprot Q05513 1182
type: UnificationXref
id: Q05513
db: uniprot

MEK1-2
type: ProteinReference
xref: P00642
standard name: Mitogen-activated protein kinase kinase 1 and 2
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.MEK1_minus_2
comment: ENTITY_REFERENCE_NOTES= Long Name: MAP/ERK kinase Synonym: Dual specificity mitogen-activated protein kinase kinase,MAP kinase kinase Accession: P00642
member entity reference: Dual specificity mitogen-activated protein kinase kinase 1
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase 1
member entity reference: Dual specificity mitogen-activated protein kinase kinase dSOR1
member entity reference: Mitogen-activated protein kinase kinase 2
member entity reference: Dual specificity mitogen-activated protein kinase kinase 2
member entity reference: Dual specificity mitogen-activated protein kinase kinase mek-2
member entity reference: MAP2K2 isoform 1
member entity reference: Protein CBR-MEK-2
member entity reference: Dual-specificity mitogen-activated protein kinase kinase 2
member entity reference: MAP2K1 protein

Fibroblast growth factor 22
type: ProteinReference
xref: uniprot Q9HCT0 130
organism: Homo sapiens

uniprot Q8I2Q4 586
type: UnificationXref
id: Q8I2Q4
db: uniprot

Protein kinase C theta type
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot Q02111 1178
organism: Mus musculus

Uncharacterized protein racC
type: ProteinReference
xref: uniprot F0ZN94 1044
xref: PTHR24072:SF310
organism: Dictyostelium purpureum

uniprot P47809 834
type: UnificationXref
id: P47809
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__RKIP-RIGHT__RKIP-_r11
controller: PKC

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot F7EH19 326
organism: Xenopus tropicalis

uniprot Q61083 761
type: UnificationXref
id: Q61083
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F6X958 462
xref: PTHR45619:SF44
organism: Canis lupus familiaris

MEK1 2 s25 a28 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot Q17941 680
type: UnificationXref
id: Q17941
db: uniprot

uniprot P21708 334
type: UnificationXref
id: P21708
db: uniprot

uniprot Q803G3 582
type: UnificationXref
id: Q803G3
db: uniprot

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P68404 1176
organism: Mus musculus

Grb2
type: ProteinReference
xref: P00631
standard name: Growth factor receptor-bound protein 2
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.Grb2
comment: ENTITY_REFERENCE_NOTES= Long Name: Grb2 Synonym: sem-5 Accession: P00631
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: GRB2-related adapter protein
member entity reference: Growth factor receptor-bound protein 2a
member entity reference: Sex muscle abnormal protein 5
member entity reference: Protein enhancer of sevenless 2B
member entity reference: Protein CBR-SEM-5
member entity reference: Growth factor receptor-bound protein 2
member entity reference: GRB2-related adaptor protein

uniprot Q5ZMD1 252
type: UnificationXref
id: Q5ZMD1
db: uniprot

uniprot F7HPR8 858
type: UnificationXref
id: F7HPR8
db: uniprot

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Spry-RIGHT__Spry-_r3
control type: INHIBITION
controller: Complex (FGFR1-4/PLC_gamma/ RasGAP/PI3K/ FRS2/SHP2/ SHC/Grb2/ SOS)

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A9SI18 422
organism: Physcomitrella patens

uniprot Q6EPR6 563
type: UnificationXref
id: Q6EPR6
db: uniprot

uniprot F6QPE1 32
type: UnificationXref
id: F6QPE1
db: uniprot

Protein sprouty homolog 2
type: ProteinReference
xref: PTHR12365:SF8
xref: uniprot O43597 302
organism: Homo sapiens

uniprot P35235 1123
type: UnificationXref
id: P35235
db: uniprot

uniprot Q12526 724
type: UnificationXref
id: Q12526
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot Q9DFC9 125
organism: Danio rerio

uniprot F7H808 476
type: UnificationXref
id: F7H808
db: uniprot

uniprot Q8MXI4 1028
type: UnificationXref
id: Q8MXI4
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot K7BV01 484
organism: Pan troglodytes

uniprot Q38919 1073
type: UnificationXref
id: Q38919
db: uniprot

uniprot P70378 111
type: UnificationXref
id: P70378
db: uniprot

uniprot O18178 490
type: UnificationXref
id: O18178
db: uniprot

Ras GTPase-activating protein 1
type: ProteinReference
xref: uniprot P20936 1103
xref: PTHR10194:SF19
organism: Homo sapiens

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot P70618 1022
xref: PTHR24055:SF110
organism: Rattus norvegicus

uniprot Q9ZQY6 610
type: UnificationXref
id: Q9ZQY6
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F7DVL1 1146
xref: PTHR24356:SF214
organism: Xenopus tropicalis

uniprot A8WWD7 961
type: UnificationXref
id: A8WWD7
db: uniprot

Ras-related protein Rac1
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P40792 1060
organism: Drosophila melanogaster

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot H2QAS6 1150
organism: Pan troglodytes

ncbitaxon 44689 213
type: UnificationXref
id: 44689
db: ncbitaxon

Protein kinase C
type: ProteinReference
xref: uniprot Q5ANK2 1186
xref: PTHR24356:SF390
organism: Candida albicans

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot Q9JHG7 935
organism: Mus musculus

uniprot F1PS03 844
type: UnificationXref
id: F1PS03
db: uniprot

FRS2 s18 sa10 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FRS2
stoichiometric coefficient: 1.0

uniprot Q7RVK6 261
type: UnificationXref
id: Q7RVK6
db: uniprot

Fibroblast growth factor 3
type: ProteinReference
xref: uniprot P11487 83
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
type: ProteinReference
xref: uniprot Q0P594 531
xref: PTHR45619:SF44
organism: Bos taurus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r19
controller: Complex (FGFR1-4/Grb2/ SOS)

PI3K
type: ProteinReference
xref: P00640
standard name: Phosphatidylinositol 3-kinase
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.PI3K
comment: ENTITY_REFERENCE_NOTES= Long Name: phosphatidylinositol 3-kinase Synonym: 5-bisphosphate 3-kinase,Phosphatidylinositol-4 Accession: P00640
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
member entity reference: AGAP011036-PA (Fragment)
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
member entity reference: Phosphatidylinositol 3-kinase catalytic subunit type 3
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
member entity reference: Uncharacterized protein
member entity reference: PIK3C2A isoform 5
member entity reference: Phosphatidylinositol 3-kinase 3
member entity reference: LD28067p
member entity reference: AGAP000018-PA
member entity reference: Phosphatidylinositol 3-kinase piki-1
member entity reference: Phosphatidylinositol 3-kinase VPS34
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
member entity reference: PI-3 kinase
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: PIK3CG isoform 1
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
member entity reference: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
member entity reference: Phosphatidylinositol 3-kinase 1
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
member entity reference: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
member entity reference: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
member entity reference: Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide (Predicted), isoform CRA_a
member entity reference: Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
member entity reference: Phosphatidylinositol 3-kinase vps34
member entity reference: Phosphatidylinositol 3-kinase age-1
member entity reference: Phosphatidylinositol 3-kinase VPS34-like
member entity reference: Phosphatidylinositol 3-kinase 2

ncbitaxon 185431 546
type: UnificationXref
id: 185431
db: ncbitaxon

ncbitaxon 7165 139
type: UnificationXref
id: 7165
db: ncbitaxon

Protein TWIN SISTER of FT
type: ProteinReference
xref: uniprot Q9S7R5 638
organism: Arabidopsis thaliana

uniprot F6SM70 797
type: UnificationXref
id: F6SM70
db: uniprot

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: uniprot Q8WU20 783
xref: PTHR21258:SF40
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
type: ProteinReference
xref: uniprot P56932 513
organism: Rattus norvegicus

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P47196 678
organism: Rattus norvegicus

uniprot P32838 502
type: UnificationXref
id: P32838
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P47197 679
organism: Rattus norvegicus

uniprot Q12702 536
type: UnificationXref
id: Q12702
db: uniprot

uniprot Q9LMM5 357
type: UnificationXref
id: Q9LMM5
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot Q9TXI7 936
organism: Caenorhabditis elegans

uniprot F6TAH0 845
type: UnificationXref
id: F6TAH0
db: uniprot

ncbitaxon 6669 159
type: UnificationXref
id: 6669
db: ncbitaxon

ncbitaxon 237631 136
type: UnificationXref
id: 237631
db: ncbitaxon

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05771 1158
organism: Homo sapiens

Fibroblast growth factor receptor 3
type: ProteinReference
xref: uniprot P22607 812
xref: PTHR24416:SF505
organism: Homo sapiens

Fibroblast growth factor receptor 1
type: ProteinReference
xref: uniprot P16092 805
xref: PTHR24416:SF131
organism: Mus musculus

uniprot Q8VIN1 632
type: UnificationXref
id: Q8VIN1
db: uniprot

SOS s37 sa15 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

uniprot F6TKL3 370
type: UnificationXref
id: F6TKL3
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot A0A1D5PB76 393
xref: PTHR11871:SF5
organism: Gallus gallus

uniprot F1MAA3 444
type: UnificationXref
id: F1MAA3
db: uniprot

uniprot H9FVU5 906
type: UnificationXref
id: H9FVU5
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot A0A1D5R985 1127
organism: Macaca mulatta

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: PTHR10257:SF3
xref: uniprot A8Y4R8 420
organism: Caenorhabditis briggsae

uniprot D3ZTF6 879
type: UnificationXref
id: D3ZTF6
db: uniprot

14-3-3
type: ProteinReference
xref: P00624
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.14_minus_3_minus_3
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: 14-3-3 Synonym: activator of tyrosine and tryptophan hydroxylases,protein kinase C inhibitor protein-1 (KCIP-1) Accession: P00624
member entity reference: SFN isoform 1
member entity reference: 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
member entity reference: 14-3-3 protein zeta/delta
member entity reference: 14-3-3 protein beta/alpha
member entity reference: 14-3-3-like protein GF14 mu
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
member entity reference: 14-3-3 protein sigma
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
member entity reference: 14-3-3-like protein GF14-G
member entity reference: 14-3-3-like protein GF14-B
member entity reference: 14-3-3 protein epsilon
member entity reference: 14-3-3 protein gamma
member entity reference: 14-3-3 protein eta
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
member entity reference: Uncharacterized protein
member entity reference: 14-3-3-like protein GF14-A
member entity reference: 14-3-3 family protein 7
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
member entity reference: AGR107Cp
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
member entity reference: 14-3-3 zeta
member entity reference: Putative 14-3-3 family protein BMH1
member entity reference: 14-3-3 family protein
member entity reference: 14-3-3 protein 3
member entity reference: Protein BMH2
member entity reference: 14-3-3 protein homolog
member entity reference: 14-3-3-like protein 2
member entity reference: 14-3-3 protein zeta
member entity reference: AGAP007643-PA
member entity reference: 14-3-3-like protein GF14 kappa
member entity reference: 14-3-3 protein beta/alpha-A
member entity reference: 14-3-3-like protein GF14 epsilon
member entity reference: 14-3-3 protein, putative
member entity reference: Protein BMH1
member entity reference: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1
member entity reference: 14-3-3 protein theta
member entity reference: 14-3-3-like protein GF14-C
member entity reference: General regulatory factor 13
member entity reference: 14-3-3 protein 2
member entity reference: 14-3-3 protein
member entity reference: DNA damage checkpoint protein rad25
member entity reference: 14-3-3-like protein GF14-E
member entity reference: 14-3-3-like protein GF14 lambda
member entity reference: ARTA
member entity reference: 14-3-3 protein 1

Phosphatidylethanolamine-binding protein 4
type: ProteinReference
xref: uniprot Q9D9G2 636
organism: Mus musculus

uniprot A0A1D5R6Y2 399
type: UnificationXref
id: A0A1D5R6Y2
db: uniprot

PLCgamma s15 sa7 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: PLCgamma
stoichiometric coefficient: 1.0

p38 s54 a67 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot Q07100 526
type: UnificationXref
id: Q07100
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot E2RNP2 1137
organism: Canis lupus familiaris

Protein sprouty homolog 1
type: ProteinReference
xref: uniprot F7GQV4 298
xref: PTHR12365:SF10
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r26 1274
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r26 1275
type: Stoichiometry
physical entity: p38
stoichiometric coefficient: 1.0

PTHR24070:SF189
type: RelationshipXref
id: PTHR24070:SF189
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot A0A3Q1LJZ7 1003
xref: PTHR24055:SF146
organism: Bos taurus

uniprot P24723 1167
type: UnificationXref
id: P24723
db: uniprot

Mitogen-activated protein kinase pmk-2
type: ProteinReference
xref: uniprot Q8MXI4 1028
xref: PTHR24055:SF154
organism: Caenorhabditis elegans

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 139

RasGAP s16 sa8 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: RasGAP
stoichiometric coefficient: 1.0

uniprot Q9Z1B7 1035
type: UnificationXref
id: Q9Z1B7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F3S0 897
xref: PTHR10048:SF33
organism: Macaca mulatta

GTPase KRas
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F6Z5N3 701
organism: Monodelphis domestica

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot A0A2I3TIS1 789
xref: PTHR24416:SF505
organism: Pan troglodytes

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot Q62925 763
organism: Rattus norvegicus

14-3-3-like protein GF14 lambda
type: ProteinReference
xref: uniprot P48349 211
xref: PTHR18860:SF69
organism: Arabidopsis thaliana

uniprot P16054 1162
type: UnificationXref
id: P16054
db: uniprot

14-3-3-like protein GF14 kappa
type: ProteinReference
xref: uniprot P48348 210
xref: PTHR18860:SF112
organism: Arabidopsis thaliana

uniprot A0A2I3THL4 987
type: UnificationXref
id: A0A2I3THL4
db: uniprot

14-3-3-like protein GF14 epsilon
type: ProteinReference
xref: uniprot P48347 209
xref: PTHR18860:SF72
organism: Arabidopsis thaliana

uniprot A0A1D5PXC6 362
type: UnificationXref
id: A0A1D5PXC6
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot A0A1D5QKD3 959
xref: PTHR48013:SF5
organism: Macaca mulatta

RAS p21 protein activator 2
type: ProteinReference
xref: PTHR10194:SF21
xref: uniprot H2QNH9 1100
organism: Pan troglodytes

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RSB0 1008
xref: PTHR24055:SF146
organism: Canis lupus familiaris

uniprot O70173 912
type: UnificationXref
id: O70173
db: uniprot

uniprot P63104 224
type: UnificationXref
id: P63104
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot P48736 920
organism: Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H2PXY8 903
xref: PTHR10048:SF35
organism: Pan troglodytes

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF0
xref: uniprot A8WWS6 419
organism: Caenorhabditis briggsae

Protein TERMINAL FLOWER 1
type: ProteinReference
xref: uniprot P93003 626
organism: Arabidopsis thaliana

MKK4,7
type: Protein
entity reference: MKK4,7
feature: ACTIVE 287
feature: MKK4,7 s48 a62 rs1
feature: MKK4,7 s48 a62 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F7BU66 177
type: UnificationXref
id: F7BU66
db: uniprot

uniprot F4IA59 165
type: UnificationXref
id: F4IA59
db: uniprot

uniprot Q503B6 726
type: UnificationXref
id: Q503B6
db: uniprot

ncbitaxon 6239 203
type: UnificationXref
id: 6239
db: ncbitaxon

Fibroblast growth factor
type: ProteinReference
xref: uniprot F7F3R0 49
organism: Macaca mulatta

FGFR1-4
type: Protein
entity reference: FGFR1-4
feature: FGFR1 4 s8 sa6 rs4
feature: FGFR1 4 s8 sa6 rs3
feature: FGFR1 4 s8 sa6 rs2
feature: ACTIVE 287
feature: FGFR1 4 s8 sa6 rs1

uniprot Q5Z859 349
type: UnificationXref
id: Q5Z859
db: uniprot

uniprot F6X3A7 461
type: UnificationXref
id: F6X3A7
db: uniprot

14-3-3-like protein GF14 omega
type: ProteinReference
xref: uniprot Q01525 232
xref: PTHR18860:SF83
organism: Arabidopsis thaliana

uniprot H2PXY8 903
type: UnificationXref
id: H2PXY8
db: uniprot

uniprot Q567Y8 554
type: UnificationXref
id: Q567Y8
db: uniprot

uniprot P49186 381
type: UnificationXref
id: P49186
db: uniprot

IPI
type: EvidenceCodeVocabulary
xref: eco ECO:0000353 193

uniprot P48349 211
type: UnificationXref
id: P48349
db: uniprot

uniprot J9NVD5 64
type: UnificationXref
id: J9NVD5
db: uniprot

Protein sprouty
type: ProteinReference
xref: uniprot O44783 305
xref: PTHR12365:SF7
organism: Drosophila melanogaster

uniprot F7BRK5 991
type: UnificationXref
id: F7BRK5
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot F1MAA3 444
organism: Rattus norvegicus

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot P16054 1162
organism: Mus musculus

uniprot F6TA21 166
type: UnificationXref
id: F6TA21
db: uniprot

uniprot Q9TU25 1088
type: UnificationXref
id: Q9TU25
db: uniprot

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot H9FYU7 948
xref: PTHR23113:SF150
organism: Macaca mulatta

uniprot A0A2I3SR38 1129
type: UnificationXref
id: A0A2I3SR38
db: uniprot

uniprot Q9WUI1 1034
type: UnificationXref
id: Q9WUI1
db: uniprot

uniprot P31946 198
type: UnificationXref
id: P31946
db: uniprot

uniprot Q4KSH7 836
type: UnificationXref
id: Q4KSH7
db: uniprot

uniprot O57341 73
type: UnificationXref
id: O57341
db: uniprot

uniprot A0A2J8NIY5 13
type: UnificationXref
id: A0A2J8NIY5
db: uniprot

uniprot A0A1D5QAB6 1090
type: UnificationXref
id: A0A1D5QAB6
db: uniprot

uniprot F7BS95 176
type: UnificationXref
id: F7BS95
db: uniprot

uniprot E2RCV1 883
type: UnificationXref
id: E2RCV1
db: uniprot

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
type: ProteinReference
xref: uniprot E9QAN8 885
xref: PTHR10048:SF30
organism: Mus musculus

phosphorylated residue
type: SequenceModificationVocabulary
xref: 00696
comment: DATA_SOURCE=CellDesigner

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F1PMN2 369
organism: Canis lupus familiaris

PTHR10337:SF4
type: RelationshipXref
id: PTHR10337:SF4
db: PANTHER Family
relationship type: By Homology

PTHR10337:SF2
type: RelationshipXref
id: PTHR10337:SF2
db: PANTHER Family
relationship type: By Homology

uniprot Q380S1 628
type: UnificationXref
id: Q380S1
db: uniprot

ncbitaxon 10116 54
type: UnificationXref
id: 10116
db: ncbitaxon

Fibroblast growth factor 17
type: ProteinReference
xref: uniprot O60258 74
xref: PTHR11486:SF71
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot F1M9D0 740
xref: PTHR24361:SF342
organism: Rattus norvegicus

uniprot A0MTF4 14
type: UnificationXref
id: A0MTF4
db: uniprot

FGFR1 4 s1 sa1 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.75

uniprot E2RTC7 24
type: UnificationXref
id: E2RTC7
db: uniprot

uniprot A8Y4R8 420
type: UnificationXref
id: A8Y4R8
db: uniprot

uniprot Q15283 1106
type: UnificationXref
id: Q15283
db: uniprot

Phytochrome-associated serine/threonine-protein phosphatase 1
type: ProteinReference
xref: uniprot Q9SX52 600
organism: Arabidopsis thaliana

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7FHD1 328
xref: PTHR24055:SF203
organism: Monodelphis domestica

uniprot O09110 280
type: UnificationXref
id: O09110
db: uniprot

RKIP s30 a33 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

Protein phosphatase PP2A regulatory subunit B
type: ProteinReference
xref: uniprot A7ERB7 414
xref: PTHR11871:SF0
organism: Sclerotinia sclerotiorum

uniprot H2PZQ7 704
type: UnificationXref
id: H2PZQ7
db: uniprot

uniprot Q9EST9 129
type: UnificationXref
id: Q9EST9
db: uniprot

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot O00443 908
organism: Homo sapiens

uniprot F1PRG4 665
type: UnificationXref
id: F1PRG4
db: uniprot

PTHR24072:SF179
type: RelationshipXref
id: PTHR24072:SF179
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot Q4QQQ5 837
organism: Xenopus tropicalis

uniprot A5D7R9 688
type: UnificationXref
id: A5D7R9
db: uniprot

PARTICIPANT STOICHIOMETRY r9 1257
type: Stoichiometry
physical entity: MEK1-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r9 1256
type: Stoichiometry
physical entity: MEK1-2
stoichiometric coefficient: 1.0

uniprot P45984 380
type: UnificationXref
id: P45984
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2RKA7 1007
xref: PTHR24055:SF107
organism: Canis lupus familiaris

RAS p21 protein activator (GTPase activating protein) 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot H2QR74 1101
organism: Pan troglodytes

FGFR1 4 s1 sa1 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot E1BHC1 19
type: UnificationXref
id: E1BHC1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F5HEA9 323
xref: PTHR24055:SF158
organism: Phaeosphaeria nodorum

uniprot Q94124 1086
type: UnificationXref
id: Q94124
db: uniprot

uniprot Q15759 1023
type: UnificationXref
id: Q15759
db: uniprot

uniprot F6USY2 745
type: UnificationXref
id: F6USY2
db: uniprot

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: PTHR11584:SF332
xref: uniprot Q99683 764
organism: Homo sapiens

PHYSICAL_STIMULATION
type: Control
xref: PHYSICAL STIMULATION
controlled: Mitogenesis Differentiation
controller: ERK1-2

Mitogen-activated protein kinase kinase kinase 6
type: ProteinReference
xref: uniprot O95382 758
xref: PTHR11584:SF391
organism: Homo sapiens

PI-3 kinase
type: ProteinReference
xref: uniprot P91634 926
xref: PTHR10048:SF14
organism: Drosophila melanogaster

PLCgamma
type: Protein
entity reference: PLCgamma
feature: COMPLEX PARTICIPANT BINDING FEATURE s15 sa7 1207
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O43597 302
type: UnificationXref
id: O43597
db: uniprot

uniprot A0A3Q1LWJ8 364
type: UnificationXref
id: A0A3Q1LWJ8
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6XSJ9 1048
xref: PTHR24072:SF136
organism: Macaca mulatta

HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-RIGHT__Complex__Grb2_SOS_-_r31
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1243
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1244
participant stoichiometry: PARTICIPANT STOICHIOMETRY r31 1245
left: Grb2
left: SOS
interaction type: HETERODIMER_ASSOCIATION
right: Complex (Grb2/SOS)

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 1002
xref: PTHR44329:SF22
xref: uniprot Q99N57 1001
organism: Mus musculus

uniprot F7G755 474
type: UnificationXref
id: F7G755
db: uniprot

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 69

uniprot F1MYM3 887
type: UnificationXref
id: F1MYM3
db: uniprot

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
type: ProteinReference
xref: uniprot Q4QQT4 551
organism: Rattus norvegicus

Protein phosphatase PP2A regulatory subunit A
type: ProteinReference
xref: uniprot Q9UT08 602
organism: Schizosaccharomyces pombe

FGFR1 4 s1 sa1 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
type: ProteinReference
xref: uniprot Q38845 547
organism: Arabidopsis thaliana

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
type: ProteinReference
xref: PTHR11871:SF1
xref: uniprot Q6ZWR4 570
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: uniprot A7F871 689
organism: Sclerotinia sclerotiorum

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot B7QHS1 430
organism: Ixodes scapularis

Protein phosphatase PP2A regulatory subunit B
type: ProteinReference
xref: uniprot Q0TVB5 532
xref: PTHR11871:SF0
organism: Phaeosphaeria nodorum

uniprot A0A2I3TIS1 789
type: UnificationXref
id: A0A2I3TIS1
db: uniprot

uniprot Q07890 953
type: UnificationXref
id: Q07890
db: uniprot

MKK3,6
type: Protein
entity reference: MKK3,6
feature: MKK3,6 s52 a65 rs2
feature: ACTIVE 287
feature: MKK3,6 s52 a65 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

RCG41526, isoform CRA_a
type: ProteinReference
xref: uniprot B5DFH3 291
xref: PTHR12365:SF10
organism: Rattus norvegicus

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s4 sa3 1199
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q6NY64 566
type: UnificationXref
id: Q6NY64
db: uniprot

14-3-3-like protein GF14-G
type: ProteinReference
xref: uniprot Q5QNB8 247
xref: PTHR18860:SF17
organism: Oryza sativa

FRS2
type: Protein
entity reference: FRS2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6Y4G8 372
organism: Canis lupus familiaris

uniprot P54130 100
type: UnificationXref
id: P54130
db: uniprot

uniprot H2Q8X8 481
type: UnificationXref
id: H2Q8X8
db: uniprot

uniprot P48529 511
type: UnificationXref
id: P48529
db: uniprot

uniprot Q21029 760
type: UnificationXref
id: Q21029
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot Q1HG70 974
organism: Canis lupus familiaris

MAP3K5 isoform 1
type: ProteinReference
xref: uniprot K7CFQ9 755
xref: PTHR11584:SF332
organism: Pan troglodytes

uniprot P05524 79
type: UnificationXref
id: P05524
db: uniprot

Fibroblast growth factor 18
type: ProteinReference
xref: PTHR11486:SF4
xref: uniprot O76093 75
organism: Homo sapiens

uniprot Q9Z268 1109
type: UnificationXref
id: Q9Z268
db: uniprot

FGFR1 4 s1 sa1 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.64
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF27
xref: uniprot H2R396 63
organism: Pan troglodytes

p38 s54 a67 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot A8WGP3 418
type: UnificationXref
id: A8WGP3
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F1N1S8 447
xref: PTHR10257:SF89
organism: Bos taurus

uniprot P21803 809
type: UnificationXref
id: P21803
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot A0A1D5QTA0 7
xref: PTHR11486:SF77
organism: Macaca mulatta

uniprot F6QP11 668
type: UnificationXref
id: F6QP11
db: uniprot

uniprot Q8IS21 957
type: UnificationXref
id: Q8IS21
db: uniprot

uniprot P47811 1020
type: UnificationXref
id: P47811
db: uniprot

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot P08642 712
organism: Gallus gallus

Fibroblast growth factor receptor
type: ProteinReference
xref: PTHR24416:SF130
xref: uniprot A0A3Q1LRU7 790
organism: Bos taurus

uniprot Q9C004 308
type: UnificationXref
id: Q9C004
db: uniprot

PTHR24072:SF169
type: RelationshipXref
id: PTHR24072:SF169
db: PANTHER Family
relationship type: By Homology

Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B' delta isoform
type: ProteinReference
xref: uniprot Q9ZQY6 610
organism: Arabidopsis thaliana

Fibroblast growth factor receptor
type: ProteinReference
xref: PTHR24416:SF130
xref: uniprot F6YFR4 800
organism: Xenopus tropicalis

uniprot P32254 721
type: UnificationXref
id: P32254
db: uniprot

GDP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 7227 195
type: UnificationXref
id: 7227
db: ncbitaxon

Serine/threonine-protein phosphatase PP2A-2 catalytic subunit
type: ProteinReference
xref: uniprot Q07098 525
organism: Arabidopsis thaliana

Ras-like protein 1
type: ProteinReference
xref: uniprot P08647 714
organism: Schizosaccharomyces pombe

uniprot F7C798 1013
type: UnificationXref
id: F7C798
db: uniprot

Ras-like protein 1
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot P08646 713
organism: Drosophila melanogaster

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot E9G8K4 437
organism: Daphnia pulex

uniprot Q6RUV5 1081
type: UnificationXref
id: Q6RUV5
db: uniprot

uniprot P13677 1161
type: UnificationXref
id: P13677
db: uniprot

PTHR24072:SF136
type: RelationshipXref
id: PTHR24072:SF136
db: PANTHER Family
relationship type: By Homology

uniprot Q92529 867
type: UnificationXref
id: Q92529
db: uniprot

uniprot F1P630 368
type: UnificationXref
id: F1P630
db: uniprot

Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a
type: ProteinReference
xref: uniprot Q5XI34 557
xref: PTHR10648:SF2
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6V332 1010
xref: PTHR24055:SF110
organism: Macaca mulatta

uniprot P16892 333
type: UnificationXref
id: P16892
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
type: ProteinReference
xref: uniprot P36877 507
xref: PTHR11871:SF1
organism: Rattus norvegicus

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s2 sa2 1197
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q66JE6 980
type: UnificationXref
id: Q66JE6
db: uniprot

uniprot F7BBM1 895
type: UnificationXref
id: F7BBM1
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
type: ProteinReference
xref: uniprot P36876 506
xref: PTHR11871:SF2
organism: Rattus norvegicus

uniprot A0A1D5PED5 394
type: UnificationXref
id: A0A1D5PED5
db: uniprot

uniprot P32345 501
type: UnificationXref
id: P32345
db: uniprot

uniprot P61982 215
type: UnificationXref
id: P61982
db: uniprot

Protein phosphatase PP2A 55 kDa regulatory subunit
type: ProteinReference
xref: uniprot P36872 505
organism: Drosophila melanogaster

uniprot F6SZ66 890
type: UnificationXref
id: F6SZ66
db: uniprot

uniprot Q3T0N5 1026
type: UnificationXref
id: Q3T0N5
db: uniprot

Serine/threonine-protein phosphatase PP2A catalytic subunit
type: ProteinReference
xref: uniprot Q9HFQ2 594
organism: Emericella nidulans

uniprot O62618 1019
type: UnificationXref
id: O62618
db: uniprot

HETERODIMER_ASSOCIATION
type: InteractionVocabulary

PTHR45619:SF25
type: RelationshipXref
id: PTHR45619:SF25
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor 4
type: ProteinReference
xref: PTHR11486:SF31
xref: uniprot P08620 80
organism: Homo sapiens

uniprot Q8INB9 683
type: UnificationXref
id: Q8INB9
db: uniprot

uniprot Q39026 346
type: UnificationXref
id: Q39026
db: uniprot

uniprot P03967 710
type: UnificationXref
id: P03967
db: uniprot

HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-RIGHT__Complex__SOS_Grb2_-_r33
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1237
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1238
participant stoichiometry: PARTICIPANT STOICHIOMETRY r33 1239
left: Grb2
left: SOS
interaction type: HETERODIMER_ASSOCIATION
right: Complex (SOS/Grb2)

uniprot F7FRT9 181
type: UnificationXref
id: F7FRT9
db: uniprot

uniprot K7CXU1 485
type: UnificationXref
id: K7CXU1
db: uniprot

Protein BMH2
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P34730 200
organism: Saccharomyces cerevisiae

HRas proto-oncogene, GTPase a
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot F1QNG4 700
organism: Danio rerio

uniprot Q9SX52 600
type: UnificationXref
id: Q9SX52
db: uniprot

uniprot A9UJN4 426
type: UnificationXref
id: A9UJN4
db: uniprot

14-3-3-like protein 1
type: ProteinReference
xref: PTHR18860:SF21
xref: uniprot P41932 202
organism: Caenorhabditis elegans

NAS
type: EvidenceCodeVocabulary
xref: eco ECO:0000303 319

uniprot H9FYU7 948
type: UnificationXref
id: H9FYU7
db: uniprot

uniprot A0A2R8Q610 406
type: UnificationXref
id: A0A2R8Q610
db: uniprot

uniprot Q60823 681
type: UnificationXref
id: Q60823
db: uniprot

Mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot A0A3S5ZPX3 960
organism: Bos taurus

ncbitaxon 10228 428
type: UnificationXref
id: 10228
db: ncbitaxon

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot P09217 1160
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase VPS34-like
type: ProteinReference
xref: uniprot P54676 925
xref: PTHR10048:SF7
organism: Dictyostelium discoideum

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P09215 1159
organism: Rattus norvegicus

Phosphatidylinositol 3-kinase 3
type: ProteinReference
xref: PTHR10048:SF48
xref: uniprot P54675 924
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot F1MYM3 887
xref: PTHR10048:SF33
organism: Bos taurus

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: PTHR10257:SF5
xref: uniprot Q9VB23 603
organism: Drosophila melanogaster

Phosphatidylinositol 3-kinase 2
type: ProteinReference
xref: uniprot P54674 923
xref: PTHR10048:SF109
organism: Dictyostelium discoideum

Phosphatidylinositol 3-kinase 1
type: ProteinReference
xref: uniprot P54673 922
xref: PTHR10048:SF14
organism: Dictyostelium discoideum

FGFR1 4 s84 a46 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

uniprot A0A2I3RMA9 788
type: UnificationXref
id: A0A2I3RMA9
db: uniprot

Mitogen-activated protein kinase 3
type: ProteinReference
xref: uniprot Q6Z437 352
organism: Oryza sativa

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P10686 849
xref: PTHR10336:SF173
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot F6X3A7 461
organism: Macaca mulatta

uniprot O04376 488
type: UnificationXref
id: O04376
db: uniprot

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P34722 1169
xref: PTHR24356:SF347
organism: Caenorhabditis elegans

SHC
type: Protein
entity reference: SHC
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P36179 503
type: UnificationXref
id: P36179
db: uniprot

uniprot Q9FXT7 356
type: UnificationXref
id: Q9FXT7
db: uniprot

PTHR45619:SF42
type: RelationshipXref
id: PTHR45619:SF42
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor 2
type: ProteinReference
xref: uniprot P48798 95
organism: Monodelphis domestica

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A7T2Q5 417
xref: PTHR45619:SF12
organism: Nematostella vectensis

uniprot O43374 1102
type: UnificationXref
id: O43374
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot F7H3B3 1147
organism: Macaca mulatta

uniprot O70456 191
type: UnificationXref
id: O70456
db: uniprot

PTHR24072:SF127
type: RelationshipXref
id: PTHR24072:SF127
db: PANTHER Family
relationship type: By Homology

PTHR45619:SF44
type: RelationshipXref
id: PTHR45619:SF44
db: PANTHER Family
relationship type: By Homology

uniprot A0A0G2JZD1 392
type: UnificationXref
id: A0A0G2JZD1
db: uniprot

Phosphatidylethanolamine-binding protein 1
type: ProteinReference
xref: uniprot P30086 622
xref: PTHR11362:SF109
organism: Homo sapiens

Fibroblast growth factor receptor substrate 3
type: ProteinReference
xref: uniprot J9NT83 780
organism: Canis lupus familiaris

Uncharacterized protein
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot A0A1D5QJY6 872
organism: Macaca mulatta

Protein kinase C delta type
type: ProteinReference
xref: uniprot H9EU39 1152
xref: PTHR24356:SF365
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YLW2 746
xref: PTHR24361:SF342
organism: Macaca mulatta

uniprot K7CBH8 1153
type: UnificationXref
id: K7CBH8
db: uniprot

PTHR12365:SF10
type: RelationshipXref
id: PTHR12365:SF10
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q3T0N5 1026
xref: PTHR24055:SF107
organism: Bos taurus

uniprot A0A3Q1MMD9 841
type: UnificationXref
id: A0A3Q1MMD9
db: uniprot

uniprot Q90Z00 819
type: UnificationXref
id: Q90Z00
db: uniprot

uniprot P23635 496
type: UnificationXref
id: P23635
db: uniprot

FGFR1 4 s84 a46 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.75

Rac-like GTP-binding protein 7
type: ProteinReference
xref: uniprot Q6Z7L8 1082
organism: Oryza sativa

uniprot F7GWP9 475
type: UnificationXref
id: F7GWP9
db: uniprot

Tyrosine-protein phosphatase non-receptor type 11
type: ProteinReference
xref: PTHR46559:SF3
xref: uniprot Q90687 1126
organism: Gallus gallus

Fibroblast growth factor receptor 4
type: ProteinReference
xref: PTHR24416:SF343
xref: uniprot Q498D6 816
organism: Rattus norvegicus

uniprot F7EI48 327
type: UnificationXref
id: F7EI48
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P67775 521
xref: PTHR45619:SF42
organism: Homo sapiens

uniprot O00443 908
type: UnificationXref
id: O00443
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P67774 520
xref: PTHR45619:SF42
organism: Bos taurus

uniprot E1C021 775
type: UnificationXref
id: E1C021
db: uniprot

uniprot F0ZI47 695
type: UnificationXref
id: F0ZI47
db: uniprot

uniprot P31749 675
type: UnificationXref
id: P31749
db: uniprot

uniprot Q9DGE1 1030
type: UnificationXref
id: Q9DGE1
db: uniprot

PTHR24072:SF105
type: RelationshipXref
id: PTHR24072:SF105
db: PANTHER Family
relationship type: By Homology

Harvey rat sarcoma viral oncogene homolog
type: ProteinReference
xref: PTHR24070:SF423
xref: uniprot Q28EW2 725
organism: Xenopus tropicalis

Sprouty RTK signaling antagonist 4
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot F1Q4C2 295
organism: Canis lupus familiaris

uniprot O08911 1015
type: UnificationXref
id: O08911
db: uniprot

FGFR1 4 s84 a46 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.64
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

Fibroblast growth factor 6
type: ProteinReference
xref: uniprot P21658 89
xref: PTHR11486:SF25
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A0R4IKK9 361
xref: PTHR24055:SF162
organism: Danio rerio

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot O97259 493
organism: Plasmodium falciparum

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot E9I1I7 693
organism: Daphnia pulex

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot Q8CIH5 854
xref: PTHR10336:SF25
organism: Mus musculus

uniprot Q91Y86 388
type: UnificationXref
id: Q91Y86
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1MYJ4 664
xref: PTHR24356:SF190
organism: Bos taurus

uniprot Q6PC73 656
type: UnificationXref
id: Q6PC73
db: uniprot

uniprot E9PYG6 1095
type: UnificationXref
id: E9PYG6
db: uniprot

Ras GTPase-activating protein 2
type: ProteinReference
xref: PTHR10194:SF21
xref: uniprot Q15283 1106
organism: Homo sapiens

JNK1-3
type: Protein
entity reference: JNK1-3
feature: JNK1 3 s50 a63 rs2
feature: ACTIVE 287
feature: JNK1 3 s50 a63 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Candida albicans
type: BioSource
xref: ncbitaxon 237561 190

uniprot C4M8K6 1043
type: UnificationXref
id: C4M8K6
db: uniprot

uniprot F1P714 449
type: UnificationXref
id: F1P714
db: uniprot

uniprot A0A3Q1LJZ7 1003
type: UnificationXref
id: A0A3Q1LJZ7
db: uniprot

uniprot P23298 1165
type: UnificationXref
id: P23298
db: uniprot

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: uniprot E2QSI0 776
xref: PTHR21258:SF40
organism: Canis lupus familiaris

PTHR24055:SF393
type: RelationshipXref
id: PTHR24055:SF393
db: PANTHER Family
relationship type: By Homology

uniprot A5D973 412
type: UnificationXref
id: A5D973
db: uniprot

Fibroblast growth factor 20
type: ProteinReference
xref: PTHR11486:SF72
xref: uniprot Q9NP95 133
organism: Homo sapiens

RKIP s29 a32 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot P98083 862
organism: Mus musculus

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot E2RJX4 662
organism: Canis lupus familiaris

14-3-3-like protein
type: ProteinReference
xref: uniprot P54632 212
xref: PTHR18860:SF17
organism: Dictyostelium discoideum

uniprot P48348 210
type: UnificationXref
id: P48348
db: uniprot

CENTRORADIALIS, putative, expressed
type: ProteinReference
xref: uniprot Q2QXL9 627
organism: Oryza sativa

uniprot G3V7X1 53
type: UnificationXref
id: G3V7X1
db: uniprot

PARTICIPANT STOICHIOMETRY r4 1271
type: Stoichiometry
physical entity: GTP
stoichiometric coefficient: 1.0

uniprot Q8NEB9 933
type: UnificationXref
id: Q8NEB9
db: uniprot

PTHR45619:SF12
type: RelationshipXref
id: PTHR45619:SF12
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r4 1270
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

uniprot Q76MZ3 572
type: UnificationXref
id: Q76MZ3
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 977

uniprot P08647 714
type: UnificationXref
id: P08647
db: uniprot

uniprot P35213 201
type: UnificationXref
id: P35213
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot H2QNG6 905
xref: PTHR10048:SF33
organism: Pan troglodytes

uniprot P62714 514
type: UnificationXref
id: P62714
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F1Q4F8 666
xref: PTHR24356:SF190
organism: Canis lupus familiaris

uniprot F6RRV0 457
type: UnificationXref
id: F6RRV0
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7F3Q5 473
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A7F3M0 316
xref: PTHR24055:SF158
organism: Sclerotinia sclerotiorum

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot F1NLM6 448
xref: PTHR10257:SF92
organism: Gallus gallus

MEKK1-5
type: Protein
entity reference: MEKK1-5
feature: MEKK1 5 s38 a40 rs1
feature: MEKK1 5 s38 a40 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P17252 1163
type: UnificationXref
id: P17252
db: uniprot

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF67
xref: uniprot G2HI54 183
organism: Pan troglodytes

uniprot P09217 1160
type: UnificationXref
id: P09217
db: uniprot

IGI
type: EvidenceCodeVocabulary
xref: eco ECO:0000316 5

Fibroblast growth factor receptor 1-A
type: ProteinReference
xref: uniprot Q90Z00 819
organism: Danio rerio

uniprot H2Q4R4 480
type: UnificationXref
id: H2Q4R4
db: uniprot

uniprot A7F871 689
type: UnificationXref
id: A7F871
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: PTHR48016:SF32
xref: uniprot A0A0G2K3R1 732
organism: Rattus norvegicus

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r21
controller: Ras

uniprot F7H9J1 748
type: UnificationXref
id: F7H9J1
db: uniprot

uniprot F6THF0 1047
type: UnificationXref
id: F6THF0
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot G2HDV2 52
xref: PTHR11486:SF77
organism: Pan troglodytes

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q04759 1181
xref: PTHR24356:SF181
organism: Homo sapiens

Mitogen-activated protein kinase kinase kinase 6
type: ProteinReference
xref: uniprot H2PYF3 750
xref: PTHR11584:SF391
organism: Pan troglodytes

uniprot H2QRP3 301
type: UnificationXref
id: H2QRP3
db: uniprot

SOS s36 sa14 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot A0A3Q1MSP9 1130
organism: Bos taurus

uniprot F6VYS9 798
type: UnificationXref
id: F6VYS9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot F7GN93 376
organism: Macaca mulatta

uniprot P42644 204
type: UnificationXref
id: P42644
db: uniprot

FGFR1-4
type: ProteinReference
xref: P00636
comment: ENTITY_REFERENCE_NOTES= Long Name: FGFR1-4 Synonym: Synonym not specified Accession: P00636
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.RECEPTOR.FGFR1_minus_4
comment: ENTITY_REFERENCE_PROTEIN_TYPE=RECEPTOR
member entity reference: Fibroblast growth factor receptor
member entity reference: Fibroblast growth factor receptor 1
member entity reference: Fibroblast growth factor receptor 4
member entity reference: Fibroblast growth factor receptor 2
member entity reference: Fibroblast growth factor receptor 3
member entity reference: Fibroblast growth factor receptor 1-A

uniprot H2QIN7 752
type: UnificationXref
id: H2QIN7
db: uniprot

uniprot E2R0J6 436
type: UnificationXref
id: E2R0J6
db: uniprot

uniprot A9TLC7 1038
type: UnificationXref
id: A9TLC7
db: uniprot

uniprot A0NBC2 138
type: UnificationXref
id: A0NBC2
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q7PD38 573
xref: PTHR45619:SF12
organism: Anopheles gambiae

FGFR1 4 s84 a46 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot C4M323 153
type: UnificationXref
id: C4M323
db: uniprot

uniprot A8XTZ1 842
type: UnificationXref
id: A8XTZ1
db: uniprot

uniprot A7ERB7 414
type: UnificationXref
id: A7ERB7
db: uniprot

PARTICIPANT STOICHIOMETRY r4 1268
type: Stoichiometry
physical entity: GDP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r4 1269
type: Stoichiometry
physical entity: Ras
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q1K5B6 542
organism: Neurospora crassa

uniprot F0ZVH9 696
type: UnificationXref
id: F0ZVH9
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot B3S653 427
xref: PTHR45619:SF12
organism: Trichoplax adhaerens

uniprot F6SHQ2 37
type: UnificationXref
id: F6SHQ2
db: uniprot

Fibroblast growth factor 20
type: ProteinReference
xref: PTHR11486:SF72
xref: uniprot Q9ESL9 127
organism: Mus musculus

Fibroblast growth factor 16
type: ProteinReference
xref: PTHR11486:SF27
xref: uniprot Q9ESL8 126
organism: Mus musculus

uniprot Q5E9Q7 555
type: UnificationXref
id: Q5E9Q7
db: uniprot

uniprot Q8BG02 585
type: UnificationXref
id: Q8BG02
db: uniprot

uniprot F6XMN6 1142
type: UnificationXref
id: F6XMN6
db: uniprot

uniprot E7F354 157
type: UnificationXref
id: E7F354
db: uniprot

uniprot F6Y841 894
type: UnificationXref
id: F6Y841
db: uniprot

GH25425p
type: ProteinReference
xref: uniprot Q9VK60 644
organism: Drosophila melanogaster

uniprot Q5B4M9 239
type: UnificationXref
id: Q5B4M9
db: uniprot

Serine/threonine-protein phosphatase PP2A-5 catalytic subunit
type: ProteinReference
xref: uniprot O04951 489
organism: Arabidopsis thaliana

uniprot A0A2I3SQA4 402
type: UnificationXref
id: A0A2I3SQA4
db: uniprot

MKK4,7 s39 a41 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 994
xref: PTHR44329:SF22
xref: uniprot P04049 993
organism: Homo sapiens

uniprot F6XBX5 799
type: UnificationXref
id: F6XBX5
db: uniprot

uniprot A0A3Q1LUE0 791
type: UnificationXref
id: A0A3Q1LUE0
db: uniprot

uniprot H2R8U9 947
type: UnificationXref
id: H2R8U9
db: uniprot

uniprot P61328 105
type: UnificationXref
id: P61328
db: uniprot

SOS s6 sa5 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

DNA damage checkpoint protein rad24
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P42656 206
organism: Schizosaccharomyces pombe

DNA damage checkpoint protein rad25
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P42657 208
organism: Schizosaccharomyces pombe

uniprot Q61151 560
type: UnificationXref
id: Q61151
db: uniprot

PTHR24356:SF170
type: RelationshipXref
id: PTHR24356:SF170
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C3YJC1 1039
organism: Branchiostoma floridae

uniprot Q380Z0 545
type: UnificationXref
id: Q380Z0
db: uniprot

ncbitaxon 36329 149
type: UnificationXref
id: 36329
db: ncbitaxon

PTHR24356:SF171
type: RelationshipXref
id: PTHR24356:SF171
db: PANTHER Family
relationship type: By Homology

PTHR24356:SF176
type: RelationshipXref
id: PTHR24356:SF176
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P79996 384
organism: Gallus gallus

Uncharacterized protein
type: ProteinReference
xref: uniprot Q9XW37 645
organism: Caenorhabditis elegans

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P63001 1064
xref: PTHR24072:SF105
organism: Mus musculus

MKK4,7 s39 a41 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot Q3SZI4 238
type: UnificationXref
id: Q3SZI4
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: PTHR24072:SF105
xref: uniprot P63000 1063
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot F6TY10 169
organism: Monodelphis domestica

uniprot Q9XGR4 604
type: UnificationXref
id: Q9XGR4
db: uniprot

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q9Y2U5 768
xref: PTHR24361:SF342
organism: Homo sapiens

FRS2
type: Protein
entity reference: FRS2
feature: COMPLEX PARTICIPANT BINDING FEATURE s18 sa10 1213
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P61983 216
type: UnificationXref
id: P61983
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF347
xref: uniprot A8WR64 1132
organism: Caenorhabditis briggsae

uniprot F7F5K9 702
type: UnificationXref
id: F7F5K9
db: uniprot

14-3-3-like protein GF14 upsilon
type: ProteinReference
xref: PTHR18860:SF101
xref: uniprot P42645 205
organism: Arabidopsis thaliana

Ras GTPase-activating protein 4B
type: ProteinReference
xref: PTHR10194:SF4
xref: uniprot C9J798 1093
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot A0A1D5Q575 288
organism: Macaca mulatta

14-3-3-like protein GF14 psi
type: ProteinReference
xref: PTHR18860:SF95
xref: uniprot P42644 204
organism: Arabidopsis thaliana

uniprot A0A1D5PB76 393
type: UnificationXref
id: A0A1D5PB76
db: uniprot

PTHR24356:SF181
type: RelationshipXref
id: PTHR24356:SF181
db: PANTHER Family
relationship type: By Homology

FGF signaling pathway
type: Pathway
pathway component: PHYSICAL_STIMULATION
pathway component: STATE_TRANSITION_LEFT__FGFR1_4-RIGHT__FGFR1_4-_r18
pathway component: STATE_TRANSITION_LEFT__ERK1_2-RIGHT__ERK1_2-_r14
pathway component: STATE_TRANSITION_LEFT__JNK1_3-RIGHT__JNK1_3-_r24
pathway component: HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-RIGHT__Complex__Grb2_SOS_-_r31
pathway component: STATE_TRANSITION_LEFT__MEKK1_5-RIGHT__MEKK1_5-_r30
pathway component: STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r4
pathway component: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
pathway component: HETERODIMER_ASSOCIATION_LEFT__FGFR1_4-_Complex__Grb2_SOS_-RIGHT__Complex__FGFR1_4_Grb2__SOS_-_r32
pathway component: STATE_TRANSITION_LEFT__MKK3,6-RIGHT__MKK3,6-_r25
pathway component: STATE_TRANSITION_LEFT__FGFR1_4-RIGHT__FGFR1_4-_r17
pathway component: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r6
pathway component: HETERODIMER_ASSOCIATION_LEFT__FRS2-_PI3K-_PLCgamma-_RasGAP-_FGFR1_4-_SHP2-_Complex__SOS_Grb2_-_SHC-RIGHT__Complex__FGFR1_4_PLC_gamma__RasGAP_PI3K__FRS2_SHP2__SHC_Grb2__SOS_-_r34
pathway component: STATE_TRANSITION_LEFT__p38-RIGHT__p38-_r26
pathway component: HETERODIMER_ASSOCIATION_LEFT__Grb2-_SOS-RIGHT__Complex__SOS_Grb2_-_r33
pathway component: STATE_TRANSITION_LEFT__Rac-RIGHT__Rac-_r21
pathway component: STATE_TRANSITION_LEFT__MEK1_2-RIGHT__MEK1_2-_r9
pathway component: STATE_TRANSITION_LEFT__MKK4,7-RIGHT__MKK4,7-_r23
pathway component: STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r19
pathway component: STATE_TRANSITION_LEFT__RKIP-RIGHT__RKIP-_r11
pathway component: STATE_TRANSITION_LEFT__Spry-RIGHT__Spry-_r3
pathway component: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r7
xref: PANTHER Pathway P00021 1
comment: MODEL_NOTES=Panther Pathway: P00021 The FGF family of ligands consists of at least 22 members, while there are four identified FGF receptors. The activity of Individual FGFs may also differ depending on their ability to bind heparan sulfateproteoglycans. The result is the activation of many downstream pathways and many cellular outcomes, including mitogenesis, differentiation, survival, apoptosis, and cell migration. Certain FGFs are also pro-angiogenic. Mutations in three of the four receptors result in more than a dozen human congenital disease. Medline=1319744 Medline=14745970 Medline=9620845 PMID: 1319744 PMID: 14745970 PMID: 9620845

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot Q7QK56 682
xref: PTHR24356:SF333
organism: Anopheles gambiae

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot F7C798 1013
organism: Macaca mulatta

Ras
type: Protein
entity reference: Ras
feature: ACTIVE 287
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

FGFR1-4
type: Complex
component stoichiometry: FGFR1 4 s84 a46 STOICHIOMETRY ID COMPLEX
component: FGFR1-4
feature: ACTIVE 287
cellular location: cytoplasm

FGFR1-4
type: Complex
component stoichiometry: FGFR1 4 s1 sa1 STOICHIOMETRY ID COMPLEX
component: FGFR1-4
feature: ACTIVE 287
feature: COMPLEX PARTICIPANT BINDING FEATURE s1 sa1 1195
cellular location: cytoplasm

uniprot P30154 499
type: UnificationXref
id: P30154
db: uniprot

Protein kinase C-like 3
type: ProteinReference
xref: PTHR24356:SF303
xref: uniprot Q19266 1185
organism: Caenorhabditis elegans

FGFR1-4
type: Complex
component stoichiometry: FGFR1 4 s8 sa6 STOICHIOMETRY ID COMPLEX
component: FGFR1-4
feature: ACTIVE 287
feature: COMPLEX PARTICIPANT BINDING FEATURE s8 sa6 1205
cellular location: cytoplasm

uniprot O76093 75
type: UnificationXref
id: O76093
db: uniprot

General regulatory factor 13
type: ProteinReference
xref: uniprot F4IA59 165
organism: Arabidopsis thaliana

uniprot P67775 521
type: UnificationXref
id: P67775
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot A0A2I3T9Y4 659
xref: PTHR24356:SF190
organism: Pan troglodytes

uniprot Q59XU5 727
type: UnificationXref
id: Q59XU5
db: uniprot

PPP2R1B isoform 4
type: ProteinReference
xref: uniprot H2Q4R4 480
organism: Pan troglodytes

ERK1 2 s27 a30 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot A5PMV7 413
type: UnificationXref
id: A5PMV7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24072:SF325
xref: uniprot F7GY91 1049
organism: Macaca mulatta

uniprot F1P750 743
type: UnificationXref
id: F1P750
db: uniprot

eco ECO:0000353 193
type: UnificationXref
id: ECO:0000353
db: eco

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot F0ZLW0 442
organism: Dictyostelium purpureum

uniprot P36614 504
type: UnificationXref
id: P36614
db: uniprot

MKK3,6 s51 a64 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

PKC
type: ProteinReference
xref: P00648
standard name: Protein kinase C
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.PKC
comment: ENTITY_REFERENCE_NOTES= Long Name: PKC Synonym: Synonym not specified Accession: P00648
member entity reference: Protein kinase C zeta type
member entity reference: Protein kinase C
member entity reference: Protein kinase C-like 1
member entity reference: Protein kinase C eta type
member entity reference: Protein kinase C epsilon type
member entity reference: Protein kinase C theta type
member entity reference: Protein kinase C beta type
member entity reference: Protein kinase C-like 3
member entity reference: Protein kinase C-like
member entity reference: Protein kinase C gamma type (Fragment)
member entity reference: Protein kinase C gamma type
member entity reference: Protein kinase C iota type
member entity reference: AGAP012252-PA (Fragment)
member entity reference: Protein kinase C, brain isozyme
member entity reference: Protein kinase C, eye isozyme
member entity reference: Protein kinase C delta type
member entity reference: Protein kinase C-like 2
member entity reference: Protein kinase C-like 1B
member entity reference: Protein kinase C alpha type

STATE_TRANSITION_LEFT__MEKK1_5-RIGHT__MEKK1_5-_r30
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 1247
participant stoichiometry: PARTICIPANT STOICHIOMETRY r30 1246
left: MEKK1-5
interaction type: STATE_TRANSITION
right: MEKK1-5

uniprot F7DNP9 470
type: UnificationXref
id: F7DNP9
db: uniprot

PTHR24356:SF192
type: RelationshipXref
id: PTHR24356:SF192
db: PANTHER Family
relationship type: By Homology

uniprot G5EBV3 1050
type: UnificationXref
id: G5EBV3
db: uniprot

PTHR24356:SF190
type: RelationshipXref
id: PTHR24356:SF190
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor
type: ProteinReference
xref: uniprot Q9W6A1 134
xref: PTHR11486:SF17
organism: Gallus gallus

uniprot Q9DGD9 389
type: UnificationXref
id: Q9DGD9
db: uniprot

uniprot A0A3Q1LRU7 790
type: UnificationXref
id: A0A3Q1LRU7
db: uniprot

uniprot Q39027 347
type: UnificationXref
id: Q39027
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF6
xref: uniprot F6PKB8 454
organism: Monodelphis domestica

uniprot P68404 1176
type: UnificationXref
id: P68404
db: uniprot

PTHR24356:SF193
type: RelationshipXref
id: PTHR24356:SF193
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r33 1239
type: Stoichiometry
physical entity: Complex (SOS/Grb2)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r33 1237
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r33 1238
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform
type: ProteinReference
xref: uniprot O04376 488
organism: Arabidopsis thaliana

uniprot Q38912 1072
type: UnificationXref
id: Q38912
db: uniprot

ERK1 2 s27 a30 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

SHC-transforming protein 3
type: ProteinReference
xref: uniprot Q61120 865
xref: PTHR10337:SF4
organism: Mus musculus

MKK3,6 s51 a64 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot E2R9L4 739
type: UnificationXref
id: E2R9L4
db: uniprot

Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' alpha isoform
type: ProteinReference
xref: uniprot O04375 487
organism: Arabidopsis thaliana

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
type: ProteinReference
xref: uniprot Q6PD03 568
xref: PTHR10257:SF6
organism: Mus musculus

uniprot Q62245 956
type: UnificationXref
id: Q62245
db: uniprot

uniprot C4M5Z7 1042
type: UnificationXref
id: C4M5Z7
db: uniprot

uniprot G2HI54 183
type: UnificationXref
id: G2HI54
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR11362:SF82
xref: uniprot F7BYT3 618
organism: Macaca mulatta

Dual specificity mitogen-activated protein kinase kinase 7
type: ProteinReference
xref: uniprot O14733 831
organism: Homo sapiens

uniprot L7N2H4 67
type: UnificationXref
id: L7N2H4
db: uniprot

uniprot Q5U1Y2 1074
type: UnificationXref
id: Q5U1Y2
db: uniprot

uniprot F1N339 1113
type: UnificationXref
id: F1N339
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot E1B847 738
organism: Bos taurus

uniprot P27348 192
type: UnificationXref
id: P27348
db: uniprot

uniprot H2RC87 187
type: UnificationXref
id: H2RC87
db: uniprot

Dual specificity mitogen-activated protein kinase kinase mek-2
type: ProteinReference
xref: uniprot Q10664 973
xref: PTHR48013:SF19
organism: Caenorhabditis elegans

FGFR1 4 s8 sa6 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 2.0

uniprot Q1HG70 974
type: UnificationXref
id: Q1HG70
db: uniprot

Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1
type: ProteinReference
xref: uniprot O18178 490
xref: PTHR10257:SF5
organism: Caenorhabditis elegans

uniprot F1MDC9 1139
type: UnificationXref
id: F1MDC9
db: uniprot

uniprot A0A1D5Q5Z6 314
type: UnificationXref
id: A0A1D5Q5Z6
db: uniprot

uniprot Q5ZMT0 253
type: UnificationXref
id: Q5ZMT0
db: uniprot

Protein sprouty homolog 3
type: ProteinReference
xref: uniprot O43610 304
organism: Homo sapiens

Fibroblast growth factor receptor substrate 3
type: ProteinReference
xref: uniprot F7DJK6 777
organism: Macaca mulatta

Rac-like GTP-binding protein 6
type: ProteinReference
xref: PTHR24072:SF287
xref: uniprot Q6ZHA3 1083
organism: Oryza sativa

FGFR1 4 s76 a4 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

Evidence 657
type: Evidence
evidence code: ISS
comment: Website http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd

Rac-like GTP-binding protein ARAC7
type: ProteinReference
xref: uniprot O82480 1051
xref: PTHR24072:SF127
organism: Arabidopsis thaliana

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 11

uniprot O95382 758
type: UnificationXref
id: O95382
db: uniprot

uniprot Q8WQG9 387
type: UnificationXref
id: Q8WQG9
db: uniprot

uniprot A0A3Q1MPT9 792
type: UnificationXref
id: A0A3Q1MPT9
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot H2R1J0 62
xref: PTHR11486:SF71
organism: Pan troglodytes

Mitogen-activated protein kinase 11
type: ProteinReference
xref: PTHR24055:SF109
xref: uniprot Q15759 1023
organism: Homo sapiens

RKIP
type: Protein
entity reference: RKIP
feature: RKIP s29 a32 rs1
feature: ACTIVE 287
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
evidence: Evidence 985
evidence: Evidence 986
evidence: Evidence 983
evidence: Evidence 984
xref: PTHR44329:SF22
xref: uniprot A0A1D5R9U8 982
organism: Macaca mulatta

uniprot H2QNG6 905
type: UnificationXref
id: H2QNG6
db: uniprot

uniprot Q5ZIY5 558
type: UnificationXref
id: Q5ZIY5
db: uniprot

Protein sprouty homolog 1
type: ProteinReference
xref: uniprot O43609 303
xref: PTHR12365:SF10
organism: Homo sapiens

uniprot O61444 832
type: UnificationXref
id: O61444
db: uniprot

uniprot H2Q8F2 1149
type: UnificationXref
id: H2Q8F2
db: uniprot

PARTICIPANT STOICHIOMETRY r24 1278
type: Stoichiometry
physical entity: JNK1-3
stoichiometric coefficient: 1.0

uniprot Q29RC5 1068
type: UnificationXref
id: Q29RC5
db: uniprot

Serine/threonine-protein phosphatase 4 catalytic subunit 1
type: ProteinReference
xref: uniprot Q9XW79 606
organism: Caenorhabditis elegans

FGFR1 4 s76 a4 rs3
type: ModificationFeature
comment: MODIFICATION_RESIDUE_ANGLE=5.64
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

PARTICIPANT STOICHIOMETRY r24 1279
type: Stoichiometry
physical entity: JNK1-3
stoichiometric coefficient: 1.0

uniprot P27361 335
type: UnificationXref
id: P27361
db: uniprot

Protein HEADING DATE 3A
type: ProteinReference
xref: uniprot Q93WI9 634
organism: Oryza sativa

uniprot P23636 497
type: UnificationXref
id: P23636
db: uniprot

Serine/threonine-protein phosphatase 4 catalytic subunit
type: ProteinReference
xref: uniprot O76932 492
organism: Drosophila melanogaster

Fibroblast growth factor 7
type: ProteinReference
xref: PTHR11486:SF20
xref: uniprot P79150 114
organism: Canis lupus familiaris

uniprot Q8R5L7 120
type: UnificationXref
id: Q8R5L7
db: uniprot

uniprot A8KBH6 1131
type: UnificationXref
id: A8KBH6
db: uniprot

uniprot F1Q4C2 295
type: UnificationXref
id: F1Q4C2
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
type: ProteinReference
xref: uniprot Q9Y2T4 609
xref: PTHR11871:SF5
organism: Homo sapiens

uniprot A0A2R8QL35 1111
type: UnificationXref
id: A0A2R8QL35
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot F1P750 743
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot A0A2I3TP74 405
xref: PTHR11871:SF5
organism: Pan troglodytes

uniprot Q39021 342
type: UnificationXref
id: Q39021
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
type: ProteinReference
xref: uniprot Q61151 560
xref: PTHR10257:SF92
organism: Mus musculus

uniprot P63000 1063
type: UnificationXref
id: P63000
db: uniprot

uniprot O82480 1051
type: UnificationXref
id: O82480
db: uniprot

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 999
xref: PTHR44329:SF22
xref: uniprot P11345 998
organism: Rattus norvegicus

PTHR24356:SF159
type: RelationshipXref
id: PTHR24356:SF159
db: PANTHER Family
relationship type: By Homology

uniprot Q6DGB7 1077
type: UnificationXref
id: Q6DGB7
db: uniprot

PTHR24356:SF158
type: RelationshipXref
id: PTHR24356:SF158
db: PANTHER Family
relationship type: By Homology

uniprot Q6EUP4 254
type: UnificationXref
id: Q6EUP4
db: uniprot

uniprot P45985 833
type: UnificationXref
id: P45985
db: uniprot

FGFR1 4 s76 a4 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.75

PKC
type: Protein
entity reference: PKC
feature: ACTIVE 287
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot E2REA4 156
type: UnificationXref
id: E2REA4
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot O15264 1016
xref: PTHR24055:SF107
organism: Homo sapiens

uniprot Q9WTR2 767
type: UnificationXref
id: Q9WTR2
db: uniprot

uniprot H2Q4B4 55
type: UnificationXref
id: H2Q4B4
db: uniprot

uniprot Q9Y6R4 769
type: UnificationXref
id: Q9Y6R4
db: uniprot

Probable serine/threonine protein phosphatase 2A regulatory subunit B''gamma
type: ProteinReference
xref: uniprot Q8VZQ4 591
organism: Arabidopsis thaliana

RCG49355
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot D3ZJA3 292
organism: Rattus norvegicus

uniprot Q6PD03 568
type: UnificationXref
id: Q6PD03
db: uniprot

Protein kinase C
type: ProteinReference
xref: uniprot F6RA79 1141
xref: PTHR24356:SF193
organism: Monodelphis domestica

uniprot Q54PQ4 954
type: UnificationXref
id: Q54PQ4
db: uniprot

uniprot F6Y478 174
type: UnificationXref
id: F6Y478
db: uniprot

uniprot F7F5X1 703
type: UnificationXref
id: F7F5X1
db: uniprot

FGFR1 4 s76 a4 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

uniprot A6QLK6 647
type: UnificationXref
id: A6QLK6
db: uniprot

PKC
type: Protein
entity reference: PKC
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q61411 729
type: UnificationXref
id: Q61411
db: uniprot

PTHR24356:SF162
type: RelationshipXref
id: PTHR24356:SF162
db: PANTHER Family
relationship type: By Homology

GTPase NRas
type: ProteinReference
xref: uniprot Q04970 723
xref: PTHR24070:SF189
organism: Rattus norvegicus

uniprot J9NVW4 65
type: UnificationXref
id: J9NVW4
db: uniprot

uniprot A0A3Q1NH21 660
type: UnificationXref
id: A0A3Q1NH21
db: uniprot

uniprot A0A0G2K5T3 870
type: UnificationXref
id: A0A0G2K5T3
db: uniprot

Fibroblast growth factor 1
type: ProteinReference
xref: uniprot P03968 77
xref: PTHR11486:SF86
organism: Bos taurus

Ras-like protein rasD
type: ProteinReference
xref: uniprot P03967 710
xref: PTHR24070:SF418
organism: Dictyostelium discoideum

uniprot E2QUM7 1094
type: UnificationXref
id: E2QUM7
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2REA4 156
xref: PTHR18860:SF3
organism: Canis lupus familiaris

Rac-like GTPase
type: ProteinReference
xref: uniprot G5EBV3 1050
organism: Caenorhabditis elegans

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9LMM5 357
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r23 1280
type: Stoichiometry
physical entity: MKK4,7
stoichiometric coefficient: 1.0

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: uniprot A0A0G2JZZ5 770
xref: PTHR21258:SF40
organism: Rattus norvegicus

uniprot A0A0G2JTA1 391
type: UnificationXref
id: A0A0G2JTA1
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot F7DNP9 470
xref: PTHR11871:SF5
organism: Xenopus tropicalis

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q07890 953
xref: PTHR23113:SF150
organism: Homo sapiens

uniprot Q7ZSZ9 1085
type: UnificationXref
id: Q7ZSZ9
db: uniprot

Phosphoprotein phosphatase A
type: ProteinReference
xref: uniprot F0ZSC4 443
organism: Dictyostelium purpureum

uniprot P42656 206
type: UnificationXref
id: P42656
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F7B5L8 374
organism: Ornithorhynchus anatinus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q7QFY4 576
organism: Anopheles gambiae

PARTICIPANT STOICHIOMETRY r23 1281
type: Stoichiometry
physical entity: MKK4,7
stoichiometric coefficient: 1.0

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot K9J7P6 486
xref: PTHR10257:SF92
organism: Xenopus tropicalis

Fibroblast growth factor receptor 1
type: ProteinReference
xref: PTHR24416:SF131
xref: uniprot P11362 804
organism: Homo sapiens

uniprot Q17446 1025
type: UnificationXref
id: Q17446
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q7PR35 575
organism: Anopheles gambiae

uniprot A0A1D5R9U8 982
type: UnificationXref
id: A0A1D5R9U8
db: uniprot

AGAP011463-PA
type: ProteinReference
xref: uniprot Q7Q334 866
organism: Anopheles gambiae

uniprot Q91WJ0 784
type: UnificationXref
id: Q91WJ0
db: uniprot

14-3-3 protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot Q5F3W6 243
organism: Gallus gallus

uniprot A8X0X5 691
type: UnificationXref
id: A8X0X5
db: uniprot

Sprouty RTK-signaling antagonist 2
type: ProteinReference
xref: PTHR12365:SF8
xref: uniprot Q5HZA2 306
organism: Rattus norvegicus

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF4
xref: uniprot A0A2I3SED2 1091
organism: Pan troglodytes

uniprot P36507 969
type: UnificationXref
id: P36507
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot B7QGY5 429
xref: PTHR45619:SF12
organism: Ixodes scapularis

uniprot A8WR64 1132
type: UnificationXref
id: A8WR64
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F1Q6Z7 453
xref: PTHR45619:SF42
organism: Danio rerio

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 8

uniprot Q756Q2 571
type: UnificationXref
id: Q756Q2
db: uniprot

ncbitaxon 214684 245
type: UnificationXref
id: 214684
db: ncbitaxon

uniprot P19174 851
type: UnificationXref
id: P19174
db: uniprot

uniprot H2Q7R8 58
type: UnificationXref
id: H2Q7R8
db: uniprot

uniprot B7QGY5 429
type: UnificationXref
id: B7QGY5
db: uniprot

Protein son of sevenless
type: ProteinReference
xref: PTHR23113:SF341
xref: uniprot P26675 950
organism: Drosophila melanogaster

uniprot Q00362 524
type: UnificationXref
id: Q00362
db: uniprot

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: uniprot Q9TU25 1088
xref: PTHR24072:SF169
organism: Bos taurus

uniprot Q9SLI8 598
type: UnificationXref
id: Q9SLI8
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P04627 995
organism: Mus musculus

Mitogen-activated protein kinase kinase 4A
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot B1NA68 826
organism: Danio rerio

EF hand family protein, expressed
type: ProteinReference
xref: uniprot Q7XDE0 580
organism: Oryza sativa

Fibroblast growth factor
type: ProteinReference
xref: uniprot F6RWC6 36
xref: PTHR11486:SF21
organism: Macaca mulatta

uniprot P34147 1057
type: UnificationXref
id: P34147
db: uniprot

uniprot F1MN51 795
type: UnificationXref
id: F1MN51
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
type: ProteinReference
xref: uniprot Q00005 523
xref: PTHR11871:SF1
organism: Homo sapiens

Tyrosine-protein phosphatase non-receptor type ptp-2
type: ProteinReference
xref: uniprot G5EC24 1117
organism: Caenorhabditis elegans

uniprot Q93WI9 634
type: UnificationXref
id: Q93WI9
db: uniprot

uniprot P48798 95
type: UnificationXref
id: P48798
db: uniprot

uniprot E1BP37 20
type: UnificationXref
id: E1BP37
db: uniprot

PTHR24070:SF418
type: RelationshipXref
id: PTHR24070:SF418
db: PANTHER Family
relationship type: By Homology

RAF proto-oncogene serine/threonine-protein kinase
type: ProteinReference
evidence: Evidence 984
xref: PTHR44329:SF22
xref: uniprot P05625 996
organism: Gallus gallus

uniprot Q9HFQ2 594
type: UnificationXref
id: Q9HFQ2
db: uniprot

uniprot F7A1B0 42
type: UnificationXref
id: F7A1B0
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q9DGD9 389
organism: Danio rerio

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot E2R9L4 739
xref: PTHR48016:SF32
organism: Canis lupus familiaris

PTHR24361:SF342
type: RelationshipXref
id: PTHR24361:SF342
db: PANTHER Family
relationship type: By Homology

uniprot Q07889 952
type: UnificationXref
id: Q07889
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot P41743 1173
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot F1P714 449
organism: Canis lupus familiaris

uniprot A0A2I3TRY9 874
type: UnificationXref
id: A0A2I3TRY9
db: uniprot

uniprot Q6ZWR4 570
type: UnificationXref
id: Q6ZWR4
db: uniprot

AGAP013036-PA
type: ProteinReference
xref: uniprot F5HM76 617
organism: Anopheles gambiae

uniprot O23236 331
type: UnificationXref
id: O23236
db: uniprot

uniprot Q9ZNV5 646
type: UnificationXref
id: Q9ZNV5
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
type: ProteinReference
xref: uniprot Q5ZIY5 558
xref: PTHR11871:SF6
organism: Gallus gallus

Protein phosphatase 2 (Formerly 2A), regulatory subunit A, beta isoform
type: ProteinReference
xref: uniprot Q642H5 561
organism: Danio rerio

AGAP012962-PA
type: ProteinReference
xref: uniprot F5HM75 616
organism: Anopheles gambiae

uniprot Q60631 655
type: UnificationXref
id: Q60631
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F7DNM3 1098
organism: Macaca mulatta

uniprot Q03142 813
type: UnificationXref
id: Q03142
db: uniprot

uniprot E1B847 738
type: UnificationXref
id: E1B847
db: uniprot

uniprot A0A1D5Q6M6 396
type: UnificationXref
id: A0A1D5Q6M6
db: uniprot

uniprot Q9LQQ9 358
type: UnificationXref
id: Q9LQQ9
db: uniprot

Mitogen-activated protein kinase 14B
type: ProteinReference
xref: uniprot Q9DGE1 1030
xref: PTHR24055:SF110
organism: Danio rerio

Mitogen-activated protein kinase 14A
type: ProteinReference
xref: uniprot Q9DGE2 1031
xref: PTHR24055:SF110
organism: Danio rerio

uniprot F1PXD3 274
type: UnificationXref
id: F1PXD3
db: uniprot

Protein phosphatase PP2A regulatory subunit B
type: ProteinReference
xref: uniprot Q12702 536
organism: Schizosaccharomyces pombe

Fibroblast growth factor 1
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot P61149 103
organism: Rattus norvegicus

uniprot F6XFG9 171
type: UnificationXref
id: F6XFG9
db: uniprot

uniprot P48347 209
type: UnificationXref
id: P48347
db: uniprot

Fibroblast growth factor 6
type: ProteinReference
xref: uniprot P10767 81
organism: Homo sapiens

Fibroblast growth factor 1
type: ProteinReference
xref: uniprot P61148 102
xref: PTHR11486:SF86
organism: Mus musculus

PTHR24070:SF420
type: RelationshipXref
id: PTHR24070:SF420
db: PANTHER Family
relationship type: By Homology

PTHR24070:SF423
type: RelationshipXref
id: PTHR24070:SF423
db: PANTHER Family
relationship type: By Homology

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot Q5XGC8 248
xref: PTHR18860:SF28
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F7EFF6 180
organism: Macaca mulatta

uniprot Q7ZW20 264
type: UnificationXref
id: Q7ZW20
db: uniprot

Fibroblast growth factor 12
type: ProteinReference
xref: uniprot P61150 104
xref: PTHR11486:SF17
organism: Rattus norvegicus

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF145
xref: uniprot J9NVW4 65
organism: Canis lupus familiaris

ncbitaxon 7668 613
type: UnificationXref
id: 7668
db: ncbitaxon

uniprot F7GQV4 298
type: UnificationXref
id: F7GQV4
db: uniprot

uniprot A0A2I3T2U1 403
type: UnificationXref
id: A0A2I3T2U1
db: uniprot

uniprot Q05655 1183
type: UnificationXref
id: Q05655
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
type: ProteinReference
xref: uniprot O35904 910
xref: PTHR10048:SF35
organism: Mus musculus

uniprot F7DHF8 801
type: UnificationXref
id: F7DHF8
db: uniprot

uniprot C3ZG26 433
type: UnificationXref
id: C3ZG26
db: uniprot

uniprot F6QT86 455
type: UnificationXref
id: F6QT86
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF181
xref: uniprot F7HC75 1148
organism: Macaca mulatta

Fibroblast growth factor
type: ProteinReference
xref: uniprot F6WY95 40
xref: PTHR11486:SF31
organism: Xenopus tropicalis

RasGAP
type: Protein
entity reference: RasGAP
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

ncbitaxon 6238 144
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot F7F301 48
type: UnificationXref
id: F7F301
db: uniprot

14-3-3 protein epsilon
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q5ZMT0 253
organism: Gallus gallus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q1K8E8 543
organism: Neurospora crassa

uniprot P63001 1064
type: UnificationXref
id: P63001
db: uniprot

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
type: ProteinReference
xref: PTHR10648:SF2
xref: uniprot F6RRV0 457
organism: Macaca mulatta

Akt
type: Protein
entity reference: Akt
feature: Akt s21 a24 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot A0A3Q1LPF2 734
organism: Bos taurus

uniprot P01120 709
type: UnificationXref
id: P01120
db: uniprot

uniprot F6VAQ8 891
type: UnificationXref
id: F6VAQ8
db: uniprot

uniprot P05126 1154
type: UnificationXref
id: P05126
db: uniprot

uniprot Q16539 1024
type: UnificationXref
id: Q16539
db: uniprot

uniprot Q5XGC8 248
type: UnificationXref
id: Q5XGC8
db: uniprot

FGFR1 4 s8 sa6 rs4
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.0

uniprot F1PX98 452
type: UnificationXref
id: F1PX98
db: uniprot

uniprot Q7XDE0 580
type: UnificationXref
id: Q7XDE0
db: uniprot

uniprot F6QUW1 943
type: UnificationXref
id: F6QUW1
db: uniprot

uniprot Q6P4Z5 255
type: UnificationXref
id: Q6P4Z5
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot D4A3T0 938
xref: PTHR23113:SF168
organism: Rattus norvegicus

PTHR10336:SF25
type: RelationshipXref
id: PTHR10336:SF25
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QLW6 838
type: UnificationXref
id: A0A1D5QLW6
db: uniprot

STATE_TRANSITION
type: RelationshipTypeVocabulary

uniprot Q94125 934
type: UnificationXref
id: Q94125
db: uniprot

Chlamydomonas reinhardtii
type: BioSource
xref: ncbitaxon 3055 142

uniprot F1QZW4 296
type: UnificationXref
id: F1QZW4
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot H2QPS2 61
organism: Pan troglodytes

uniprot E9QAN8 885
type: UnificationXref
id: E9QAN8
db: uniprot

uniprot P68254 227
type: UnificationXref
id: P68254
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: PTHR10048:SF7
xref: uniprot E2RIF9 884
organism: Canis lupus familiaris

uniprot P22981 718
type: UnificationXref
id: P22981
db: uniprot

AGAP002219-PA
type: ProteinReference
xref: uniprot Q7QK91 730
xref: PTHR24070:SF420
organism: Anopheles gambiae

uniprot E9G8K4 437
type: UnificationXref
id: E9G8K4
db: uniprot

uniprot V5IPN6 611
type: UnificationXref
id: V5IPN6
db: uniprot

uniprot Q9Y243 686
type: UnificationXref
id: Q9Y243
db: uniprot

FGFR1 4 s8 sa6 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_ANGLE=5.64
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=

SFN isoform 1
type: ProteinReference
xref: PTHR18860:SF14
xref: uniprot H2RC87 187
organism: Pan troglodytes

uniprot Q9ESS2 128
type: UnificationXref
id: Q9ESS2
db: uniprot

uniprot Q9NP95 133
type: UnificationXref
id: Q9NP95
db: uniprot

uniprot Q9V3C8 868
type: UnificationXref
id: Q9V3C8
db: uniprot

Similar to 14-3-3 protein sigma
type: ProteinReference
xref: PTHR18860:SF14
xref: uniprot Q5EBB0 242
organism: Rattus norvegicus

uniprot Q9WTP2 312
type: UnificationXref
id: Q9WTP2
db: uniprot

Mitogen-activated protein kinase mpk-1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot P39745 338
organism: Caenorhabditis elegans

SPRY1 isoform 1
type: ProteinReference
xref: uniprot H2QQ50 300
xref: PTHR12365:SF10
organism: Pan troglodytes

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot F7EJU0 278
organism: Xenopus tropicalis

uniprot O74789 491
type: UnificationXref
id: O74789
db: uniprot

uniprot A0A2I3SB47 824
type: UnificationXref
id: A0A2I3SB47
db: uniprot

Ras
type: Protein
entity reference: Ras
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A2I3SHP7 840
xref: PTHR10336:SF25
organism: Pan troglodytes

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot P15153 1053
organism: Homo sapiens

uniprot Q84J55 265
type: UnificationXref
id: Q84J55
db: uniprot

Putative 14-3-3 family protein BMH1
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot A0A0D1E7J2 135
organism: Ustilago maydis

uniprot F1MYJ4 664
type: UnificationXref
id: F1MYJ4
db: uniprot

Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' eta isoform
type: ProteinReference
xref: uniprot Q9LU89 596
organism: Arabidopsis thaliana

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 144

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot Q8UUX0 684
organism: Danio rerio

Ras guanine nucleotide exchange factor R
type: ProteinReference
xref: uniprot Q8SSQ0 958
organism: Dictyostelium discoideum

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 203

FGFR1 4 s8 sa6 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.75

uniprot Q5TKR1 117
type: UnificationXref
id: Q5TKR1
db: uniprot

uniprot P01111 706
type: UnificationXref
id: P01111
db: uniprot

uniprot H2R1J0 62
type: UnificationXref
id: H2R1J0
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF92
xref: uniprot F6V7D9 459
organism: Canis lupus familiaris

14-3-3 protein beta/alpha
type: ProteinReference
xref: uniprot Q9CQV8 267
xref: PTHR18860:SF28
organism: Mus musculus

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
type: ProteinReference
xref: PTHR10048:SF33
xref: uniprot Q8BTI9 932
organism: Mus musculus

uniprot A0A1D5Q575 288
type: UnificationXref
id: A0A1D5Q575
db: uniprot

Raf-1 proto-oncogene, serine/threonine kinase
type: ProteinReference
evidence: Evidence 985
evidence: Evidence 986
evidence: Evidence 983
evidence: Evidence 984
xref: PTHR44329:SF22
xref: uniprot E2REI6 989
organism: Canis lupus familiaris

Map3k3 protein
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot B5DF98 736
organism: Rattus norvegicus

uniprot F1NLM6 448
type: UnificationXref
id: F1NLM6
db: uniprot

SHP2 s20 sa11 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SHP2
stoichiometric coefficient: 1.0

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q07889 952
xref: PTHR23113:SF168
organism: Homo sapiens

Mitogen-activated protein kinase 12
type: ProteinReference
xref: uniprot O08911 1015
xref: PTHR24055:SF146
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r3 1273
type: Stoichiometry
physical entity: Spry
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 1272
type: Stoichiometry
physical entity: Spry
stoichiometric coefficient: 1.0

uniprot Q9VI09 643
type: UnificationXref
id: Q9VI09
db: uniprot

uniprot Q7Q042 1190
type: UnificationXref
id: Q7Q042
db: uniprot

uniprot F6XSJ9 1048
type: UnificationXref
id: F6XSJ9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot D4A3U7 1006
xref: PTHR24055:SF109
organism: Rattus norvegicus

FGFR1 4 s8 sa6 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
type: ProteinReference
xref: uniprot Q39247 550
organism: Arabidopsis thaliana

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q95TV5 593
organism: Drosophila melanogaster

uniprot Q61831 386
type: UnificationXref
id: Q61831
db: uniprot

uniprot P15153 1053
type: UnificationXref
id: P15153
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF2
xref: uniprot F1MG56 445
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot E2R2N2 321
xref: PTHR24055:SF203
organism: Canis lupus familiaris

ncbitaxon 9258 35
type: UnificationXref
id: 9258
db: ncbitaxon

uniprot F7ELZ5 45
type: UnificationXref
id: F7ELZ5
db: uniprot

uniprot Q9ESL8 126
type: UnificationXref
id: Q9ESL8
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 3
type: ProteinReference
xref: uniprot O09110 280
xref: PTHR48013:SF21
organism: Mus musculus

PTHR18860:SF7
type: RelationshipXref
id: PTHR18860:SF7
db: PANTHER Family
relationship type: By Homology

PTHR46257:SF1
type: RelationshipXref
id: PTHR46257:SF1
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF3
type: RelationshipXref
id: PTHR18860:SF3
db: PANTHER Family
relationship type: By Homology

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
type: ProteinReference
xref: PTHR10048:SF30
xref: uniprot D3ZVF3 880
organism: Rattus norvegicus

Fibroblast growth factor 5
type: ProteinReference
xref: uniprot P12034 84
organism: Homo sapiens

uniprot A0A3Q1LSJ2 735
type: UnificationXref
id: A0A3Q1LSJ2
db: uniprot

uniprot Q8VZQ4 591
type: UnificationXref
id: Q8VZQ4
db: uniprot

PARTICIPANT STOICHIOMETRY r7 1261
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 1260
type: Stoichiometry
physical entity: Akt
stoichiometric coefficient: 1.0

uniprot B5DE89 773
type: UnificationXref
id: B5DE89
db: uniprot

ncbitaxon 284811 259
type: UnificationXref
id: 284811
db: ncbitaxon

uniprot Q62074 1188
type: UnificationXref
id: Q62074
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot P32871 915
xref: PTHR10048:SF107
organism: Bos taurus

Mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F1PBB6 827
organism: Canis lupus familiaris

uniprot F1PMN2 369
type: UnificationXref
id: F1PMN2
db: uniprot

uniprot B5DFH3 291
type: UnificationXref
id: B5DFH3
db: uniprot

uniprot F1PPW0 857
type: UnificationXref
id: F1PPW0
db: uniprot

uniprot P62999 1062
type: UnificationXref
id: P62999
db: uniprot

PTHR46257:SF4
type: RelationshipXref
id: PTHR46257:SF4
db: PANTHER Family
relationship type: By Homology

uniprot F1N6G8 26
type: UnificationXref
id: F1N6G8
db: uniprot

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 245

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A3Q1MM63 407
xref: PTHR10257:SF19
organism: Bos taurus

uniprot Q9ESL9 127
type: UnificationXref
id: Q9ESL9
db: uniprot

uniprot F0ZB76 694
type: UnificationXref
id: F0ZB76
db: uniprot

uniprot F1MY82 1140
type: UnificationXref
id: F1MY82
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF35
xref: uniprot E1BE66 882
organism: Bos taurus

uniprot Q8K2V1 587
type: UnificationXref
id: Q8K2V1
db: uniprot

uniprot E2RJX4 662
type: UnificationXref
id: E2RJX4
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot Q90XF2 1192
organism: Danio rerio

uniprot Q95TV5 593
type: UnificationXref
id: Q95TV5
db: uniprot

uniprot A0A3Q1LQK4 876
type: UnificationXref
id: A0A3Q1LQK4
db: uniprot

JNK1-3
type: Protein
entity reference: JNK1-3
feature: JNK1 3 s40 a42 rs1
feature: JNK1 3 s40 a42 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot O70143 860
type: UnificationXref
id: O70143
db: uniprot

PLCgamma
type: Protein
entity reference: PLCgamma
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

IDA
type: EvidenceCodeVocabulary

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot C8V7D1 318
xref: PTHR24055:SF158
organism: Emericella nidulans

uniprot F0ZDQ6 440
type: UnificationXref
id: F0ZDQ6
db: uniprot

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q60823 681
xref: PTHR24356:SF176
organism: Mus musculus

PTHR23113:SF168
type: RelationshipXref
id: PTHR23113:SF168
db: PANTHER Family
relationship type: By Homology

uniprot F6PQX0 30
type: UnificationXref
id: F6PQX0
db: uniprot

uniprot O16264 620
type: UnificationXref
id: O16264
db: uniprot

14-3-3 protein eta
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot P68511 230
organism: Rattus norvegicus

Protein phosphatase 2 scaffold subunit Abeta
type: ProteinReference
xref: uniprot F7A522 464
organism: Monodelphis domestica

Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB
type: ProteinReference
xref: uniprot Q54Q99 552
organism: Dictyostelium discoideum

PARTICIPANT STOICHIOMETRY r32 1240
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 2.0

14-3-3-like protein GF14 mu
type: ProteinReference
xref: PTHR18860:SF125
xref: uniprot Q96299 266
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r32 1242
type: Stoichiometry
physical entity: Complex (FGFR1-4/Grb2/ SOS)
stoichiometric coefficient: 1.0

PTHR18860:SF95
type: RelationshipXref
id: PTHR18860:SF95
db: PANTHER Family
relationship type: By Homology

Branchiostoma floridae
type: BioSource
xref: ncbitaxon 7739 432

PARTICIPANT STOICHIOMETRY r32 1241
type: Stoichiometry
physical entity: Complex (Grb2/SOS)
stoichiometric coefficient: 1.0

14-3-3 protein eta
type: ProteinReference
xref: uniprot P68510 229
xref: PTHR18860:SF16
organism: Mus musculus

uniprot K7CZM1 949
type: UnificationXref
id: K7CZM1
db: uniprot

uniprot P41932 202
type: UnificationXref
id: P41932
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot H2Q9E4 59
organism: Pan troglodytes

Uncharacterized protein
type: ProteinReference
xref: uniprot F6YCI3 945
xref: PTHR23113:SF150
organism: Monodelphis domestica

uniprot H2R396 63
type: UnificationXref
id: H2R396
db: uniprot

14-3-3-like protein GF14-B
type: ProteinReference
xref: PTHR18860:SF101
xref: uniprot Q7XTE8 263
organism: Oryza sativa

uniprot Q8AXX6 584
type: UnificationXref
id: Q8AXX6
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 4
type: ProteinReference
xref: uniprot P45985 833
xref: PTHR48013:SF20
organism: Homo sapiens

uniprot F6TY10 169
type: UnificationXref
id: F6TY10
db: uniprot

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot P45983 379
organism: Homo sapiens

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P45984 380
organism: Homo sapiens

PARTICIPANT STOICHIOMETRY r21 1227
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform
type: ProteinReference
xref: uniprot P78759 522
xref: PTHR10257:SF3
organism: Schizosaccharomyces pombe

PARTICIPANT STOICHIOMETRY r21 1226
type: Stoichiometry
physical entity: Rac
stoichiometric coefficient: 1.0

uniprot Q9LU89 596
type: UnificationXref
id: Q9LU89
db: uniprot

Complex (FGFR1-4/Grb2/ SOS)
type: Complex
component stoichiometry: SOS s4 sa3 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s2 sa2 STOICHIOMETRY ID COMPLEX
component: SOS
component: Grb2
component: FGFR1-4
feature: COMPLEX BINDING FEATURE s65 a77 1196
feature: COMPLEX BINDING FEATURE s65 a77 1194
feature: COMPLEX BINDING FEATURE s65 a77 1198
cellular location: cytoplasm

uniprot P62261 220
type: UnificationXref
id: P62261
db: uniprot

MKK3,6
type: ProteinReference
xref: P00625
standard name: Dual specificity mitogen-activated protein kinase kinase 3 and 6
comment: ENTITY_REFERENCE_NOTES= Long Name: Dual specificity mitogen-activated protein kinase kinase 3 and 6 Synonym: MAP kinase kinase 3 and 6,MAPK/ERK kinase 3 and 6,MAPKK 3 and 6 Accession: P00625
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.MKK3,6
member entity reference: Dual specificity mitogen-activated protein kinase kinase 6
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase 6
member entity reference: Mitogen-activated protein kinase kinase 3
member entity reference: Map2k3 protein
member entity reference: Dual specificity mitogen-activated protein kinase kinase 3
member entity reference: AGAP000310-PA

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot A0A3Q1MPT9 792
organism: Bos taurus

uniprot O88763 913
type: UnificationXref
id: O88763
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F6PR50 744
xref: PTHR48016:SF32
organism: Macaca mulatta

PTHR24055:SF203
type: RelationshipXref
id: PTHR24055:SF203
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF83
xref: uniprot F6SXE2 38
organism: Macaca mulatta

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P14056 1000
organism: Rattus norvegicus

uniprot A8X0R4 143
type: UnificationXref
id: A8X0R4
db: uniprot

Protein kinase C iota type
type: ProteinReference
xref: PTHR24356:SF214
xref: uniprot F1M7Y5 1138
organism: Rattus norvegicus

uniprot F1A411 698
type: UnificationXref
id: F1A411
db: uniprot

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot Q9M1Z5 359
organism: Arabidopsis thaliana

uniprot P48800 96
type: UnificationXref
id: P48800
db: uniprot

GRB2-related adaptor protein
type: ProteinReference
xref: uniprot Q4KM68 653
xref: PTHR46037:SF2
organism: Rattus norvegicus

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s6 sa5 1225
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot H2Q2P3 803
type: UnificationXref
id: H2Q2P3
db: uniprot

Protein kinase C epsilon type
type: ProteinReference
xref: PTHR24356:SF159
xref: uniprot F7BIC2 1144
organism: Macaca mulatta

Ciona intestinalis
type: BioSource
xref: ncbitaxon 7719 168

uniprot Q9I950 131
type: UnificationXref
id: Q9I950
db: uniprot

uniprot Q7TNL5 578
type: UnificationXref
id: Q7TNL5
db: uniprot

eco ECO:0000250 9
type: UnificationXref
id: ECO:0000250
db: eco

Protein kinase C gamma type
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05129 1156
organism: Homo sapiens

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot Q61411 729
organism: Mus musculus

uniprot O00750 909
type: UnificationXref
id: O00750
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot P08556 711
xref: PTHR24070:SF189
organism: Mus musculus

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot P05126 1154
organism: Bos taurus

uniprot O14733 831
type: UnificationXref
id: O14733
db: uniprot

Protein kinase C gamma type (Fragment)
type: ProteinReference
xref: PTHR24356:SF162
xref: uniprot P05128 1155
organism: Bos taurus

uniprot H2Q4B5 56
type: UnificationXref
id: H2Q4B5
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6QE96 667
xref: PTHR24356:SF176
organism: Macaca mulatta

Fibroblast growth factor 8
type: ProteinReference
xref: PTHR11486:SF3
xref: uniprot P55075 101
organism: Homo sapiens

uniprot Q9VB23 603
type: UnificationXref
id: Q9VB23
db: uniprot

uniprot Q5EBB0 242
type: UnificationXref
id: Q5EBB0
db: uniprot

uniprot P68255 228
type: UnificationXref
id: P68255
db: uniprot

uniprot E9H1W5 158
type: UnificationXref
id: E9H1W5
db: uniprot

uniprot P48801 97
type: UnificationXref
id: P48801
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot F1PRG4 665
organism: Canis lupus familiaris

uniprot Q6PC29 256
type: UnificationXref
id: Q6PC29
db: uniprot

PTHR18860:SF67
type: RelationshipXref
id: PTHR18860:SF67
db: PANTHER Family
relationship type: By Homology

PTHR10048:SF7
type: RelationshipXref
id: PTHR10048:SF7
db: PANTHER Family
relationship type: By Homology

uniprot Q0DBD3 529
type: UnificationXref
id: Q0DBD3
db: uniprot

Protein kinase C alpha type
type: ProteinReference
xref: PTHR24356:SF193
xref: uniprot P20444 1164
organism: Mus musculus

PTHR18860:SF69
type: RelationshipXref
id: PTHR18860:SF69
db: PANTHER Family
relationship type: By Homology

Ras GTPase-activating protein 1
type: ProteinReference
xref: uniprot F1N7N8 1097
xref: PTHR10194:SF19
organism: Bos taurus

uniprot A8XPY6 648
type: UnificationXref
id: A8XPY6
db: uniprot

ncbitaxon 3702 164
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot F7DY42 179
type: UnificationXref
id: F7DY42
db: uniprot

uniprot F1N7N8 1097
type: UnificationXref
id: F1N7N8
db: uniprot

ncbitaxon 13616 31
type: UnificationXref
id: 13616
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5RHD1 269
organism: Macaca mulatta

Protein kinase C, brain isozyme
type: ProteinReference
xref: uniprot P05130 1157
xref: PTHR24356:SF390
organism: Drosophila melanogaster

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot H2QKD0 847
xref: PTHR10336:SF173
organism: Pan troglodytes

uniprot Q9Y2T4 609
type: UnificationXref
id: Q9Y2T4
db: uniprot

Mitogen-activated protein kinase spk1
type: ProteinReference
xref: PTHR24055:SF158
xref: uniprot P27638 336
organism: Schizosaccharomyces pombe

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q756Q2 571
organism: Ashbya gossypii

Protein kinase C-like 2
type: ProteinReference
xref: uniprot P36583 1172
xref: PTHR24356:SF390
organism: Schizosaccharomyces pombe

Fibroblast growth factor 3
type: ProteinReference
xref: PTHR11486:SF26
xref: uniprot P05524 79
organism: Mus musculus

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF238
xref: uniprot A8WRD7 1005
organism: Caenorhabditis briggsae

uniprot F6PR50 744
type: UnificationXref
id: F6PR50
db: uniprot

uniprot F1QNG4 700
type: UnificationXref
id: F1QNG4
db: uniprot

Protein kinase C-like 1
type: ProteinReference
xref: uniprot P36582 1171
xref: PTHR24356:SF390
organism: Schizosaccharomyces pombe

uniprot Q8WU20 783
type: UnificationXref
id: Q8WU20
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot P10398 997
organism: Homo sapiens

uniprot F7F3R0 49
type: UnificationXref
id: F7F3R0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__Akt-RIGHT__Akt-_r7
controller: Complex (FGFR1-4/PLC_gamma/ RasGAP/PI3K/ FRS2/SHP2/ SHC/Grb2/ SOS)

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF12
xref: uniprot F0ZDJ1 438
organism: Dictyostelium purpureum

uniprot A0A0D1E7J2 135
type: UnificationXref
id: A0A0D1E7J2
db: uniprot

uniprot A0A0D1C4Y4 313
type: UnificationXref
id: A0A0D1C4Y4
db: uniprot

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot Q5E9X2 284
organism: Bos taurus

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: PTHR46257:SF4
xref: uniprot F7CWQ1 1116
organism: Monodelphis domestica

uniprot Q96299 266
type: UnificationXref
id: Q96299
db: uniprot

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot O88763 913
xref: PTHR10048:SF7
organism: Rattus norvegicus

uniprot Q8VWH2 633
type: UnificationXref
id: Q8VWH2
db: uniprot

Fibroblast growth factor 10
type: ProteinReference
xref: uniprot O35565 70
xref: PTHR11486:SF21
organism: Mus musculus

uniprot P36876 506
type: UnificationXref
id: P36876
db: uniprot

uniprot Q4KM68 653
type: UnificationXref
id: Q4KM68
db: uniprot

PTHR18860:SF83
type: RelationshipXref
id: PTHR18860:SF83
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor
type: ProteinReference
xref: uniprot F6PQX0 30
organism: Monodelphis domestica

uniprot E1BMX0 692
type: UnificationXref
id: E1BMX0
db: uniprot

uniprot P16885 850
type: UnificationXref
id: P16885
db: uniprot

uniprot Q6P365 567
type: UnificationXref
id: Q6P365
db: uniprot

uniprot P63319 1175
type: UnificationXref
id: P63319
db: uniprot

uniprot P08646 713
type: UnificationXref
id: P08646
db: uniprot

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot K7CDC2 674
xref: PTHR24356:SF176
organism: Pan troglodytes

uniprot P36583 1172
type: UnificationXref
id: P36583
db: uniprot

uniprot Q99N57 1001
type: UnificationXref
id: Q99N57
db: uniprot

Protein phosphatase PP2A regulatory subunit B
type: ProteinReference
xref: uniprot Q00362 524
organism: Saccharomyces cerevisiae

uniprot Q5QNB8 247
type: UnificationXref
id: Q5QNB8
db: uniprot

uniprot P21802 808
type: UnificationXref
id: P21802
db: uniprot

uniprot F6WA79 170
type: UnificationXref
id: F6WA79
db: uniprot

uniprot Q9UT08 602
type: UnificationXref
id: Q9UT08
db: uniprot

PTHR24055:SF238
type: RelationshipXref
id: PTHR24055:SF238
db: PANTHER Family
relationship type: By Homology

uniprot F1MBU9 886
type: UnificationXref
id: F1MBU9
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E9H8M4 160
xref: PTHR18860:SF17
organism: Daphnia pulex

uniprot P36506 968
type: UnificationXref
id: P36506
db: uniprot

STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 1265
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 1264
left: PKC
interaction type: STATE_TRANSITION
right: PKC

uniprot Q7XTE8 263
type: UnificationXref
id: Q7XTE8
db: uniprot

PTHR18860:SF72
type: RelationshipXref
id: PTHR18860:SF72
db: PANTHER Family
relationship type: By Homology

3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot E7F354 157
organism: Danio rerio

uniprot P05625 996
type: UnificationXref
id: P05625
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot E2RN01 23
xref: PTHR11486:SF72
organism: Canis lupus familiaris

ncbitaxon 237561 190
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot P23595 495
type: UnificationXref
id: P23595
db: uniprot

PTHR18860:SF21
type: RelationshipXref
id: PTHR18860:SF21
db: PANTHER Family
relationship type: By Homology

uniprot Q9XZE5 607
type: UnificationXref
id: Q9XZE5
db: uniprot

PTHR18860:SF22
type: RelationshipXref
id: PTHR18860:SF22
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: uniprot F7A0H3 175
xref: PTHR18860:SF3
organism: Ornithorhynchus anatinus

uniprot A0A1D5PWQ5 395
type: UnificationXref
id: A0A1D5PWQ5
db: uniprot

Ras guanine nucleotide exchange factor B
type: ProteinReference
xref: uniprot Q8IS21 957
organism: Dictyostelium discoideum

Uncharacterized protein
type: ProteinReference
xref: uniprot F7HFE8 749
xref: PTHR11584:SF391
organism: Macaca mulatta

SOS s4 sa3 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

uniprot P29351 1122
type: UnificationXref
id: P29351
db: uniprot

uniprot Q8IR23 1108
type: UnificationXref
id: Q8IR23
db: uniprot

uniprot F7CWQ1 1116
type: UnificationXref
id: F7CWQ1
db: uniprot

uniprot P42339 919
type: UnificationXref
id: P42339
db: uniprot

uniprot P11487 83
type: UnificationXref
id: P11487
db: uniprot

Serine/threonine protein phosphatase 2A regulatory subunit
type: ProteinReference
xref: uniprot Q7ZUQ2 581
xref: PTHR10257:SF92
organism: Danio rerio

Ras guanine nucleotide exchange factor A
type: ProteinReference
xref: uniprot Q54PQ4 954
organism: Dictyostelium discoideum

uniprot H2QSZ7 779
type: UnificationXref
id: H2QSZ7
db: uniprot

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot F1N7C3 940
xref: PTHR23113:SF168
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63085 339
xref: PTHR24055:SF203
organism: Mus musculus

Protein kinase C
type: ProteinReference
xref: PTHR24351:SF182
xref: uniprot F1MDC9 1139
organism: Bos taurus

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot P63086 340
xref: PTHR24055:SF203
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
type: ProteinReference
xref: uniprot P30154 499
organism: Homo sapiens

PTHR18860:SF28
type: RelationshipXref
id: PTHR18860:SF28
db: PANTHER Family
relationship type: By Homology

uniprot Q38951 549
type: UnificationXref
id: Q38951
db: uniprot

PTHR24416:SF130
type: RelationshipXref
id: PTHR24416:SF130
db: PANTHER Family
relationship type: By Homology

PTHR24416:SF131
type: RelationshipXref
id: PTHR24416:SF131
db: PANTHER Family
relationship type: By Homology

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
type: ProteinReference
xref: PTHR10648:SF2
xref: uniprot P30153 498
organism: Homo sapiens

Mitogen-activated protein kinase 12
type: ProteinReference
xref: PTHR24055:SF146
xref: uniprot P53778 1021
organism: Homo sapiens

uniprot F7AB62 465
type: UnificationXref
id: F7AB62
db: uniprot

PTHR18860:SF16
type: RelationshipXref
id: PTHR18860:SF16
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 10
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot P53779 383
organism: Homo sapiens

uniprot P20604 494
type: UnificationXref
id: P20604
db: uniprot

PTHR18860:SF14
type: RelationshipXref
id: PTHR18860:SF14
db: PANTHER Family
relationship type: By Homology

uniprot P92978 1065
type: UnificationXref
id: P92978
db: uniprot

uniprot F6W7C8 893
type: UnificationXref
id: F6W7C8
db: uniprot

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot F6XFG9 171
organism: Macaca mulatta

uniprot F6RLB3 456
type: UnificationXref
id: F6RLB3
db: uniprot

uniprot F7FHD1 328
type: UnificationXref
id: F7FHD1
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O23236 331
organism: Arabidopsis thaliana

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot F1MSX4 741
xref: PTHR24361:SF342
organism: Bos taurus

PTHR18860:SF17
type: RelationshipXref
id: PTHR18860:SF17
db: PANTHER Family
relationship type: By Homology

uniprot E2QZT7 155
type: UnificationXref
id: E2QZT7
db: uniprot

Rac family small GTPase 1
type: ProteinReference
xref: uniprot Q6GL60 1079
xref: PTHR24072:SF105
organism: Xenopus tropicalis

PTHR10048:SF107
type: RelationshipXref
id: PTHR10048:SF107
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot F6XMN6 1142
organism: Canis lupus familiaris

PTHR10048:SF109
type: RelationshipXref
id: PTHR10048:SF109
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
evidence: Evidence 985
evidence: Evidence 986
evidence: Evidence 983
evidence: Evidence 984
xref: PTHR44329:SF22
xref: uniprot F7BRK5 991
organism: Monodelphis domestica

Uncharacterized protein rac1A
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot F1A084 1046
organism: Dictyostelium purpureum

Dual specificity mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: uniprot Q02750 971
xref: PTHR48013:SF5
organism: Homo sapiens

Survival Apoptosis cell migration
type: Pathway

Son of sevenless homolog 1
type: ProteinReference
xref: uniprot Q62245 956
xref: PTHR23113:SF168
organism: Mus musculus

Mitogen-activated protein kinase (Fragment)
type: ProteinReference
xref: uniprot Q7PVR1 353
xref: PTHR24055:SF158
organism: Anopheles gambiae

V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
type: ProteinReference
xref: uniprot A0A2R8Q8S1 687
xref: PTHR24070:SF388
organism: Danio rerio

uniprot Q6EP31 1078
type: UnificationXref
id: Q6EP31
db: uniprot

uniprot A0A2J8MKA4 137
type: UnificationXref
id: A0A2J8MKA4
db: uniprot

uniprot Q61851 817
type: UnificationXref
id: Q61851
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF77
xref: uniprot L7N2H4 67
organism: Xenopus tropicalis

uniprot B1H230 272
type: UnificationXref
id: B1H230
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot F7F0I1 46
organism: Monodelphis domestica

uniprot F1MAI3 939
type: UnificationXref
id: F1MAI3
db: uniprot

ncbitaxon 3055 142
type: UnificationXref
id: 3055
db: ncbitaxon

PTHR24070:SF17
type: RelationshipXref
id: PTHR24070:SF17
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LWJ8 364
organism: Bos taurus

Protein sprouty homolog 2
type: ProteinReference
xref: PTHR12365:SF8
xref: uniprot Q9QXV8 310
organism: Mus musculus

Protein sprouty homolog 1
type: ProteinReference
xref: uniprot Q9QXV9 311
xref: PTHR12365:SF10
organism: Mus musculus

uniprot P63101 221
type: UnificationXref
id: P63101
db: uniprot

Growth factor receptor-bound protein 2
type: ProteinReference
evidence: Evidence 657
xref: uniprot Q6PC73 656
xref: PTHR46037:SF4
organism: Danio rerio

PTHR18860:SF31
type: RelationshipXref
id: PTHR18860:SF31
db: PANTHER Family
relationship type: By Homology

MEKK1-5
type: ProteinReference
xref: P00634
standard name: Mitogen-activated protein kinase kinase kinase
comment: ENTITY_REFERENCE_NOTES= Long Name: Mitogen-activated protein kinase kinase kinase Synonym: MAPK/ERK kinase kinase,MEK kinase Accession: P00634
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.MEKK1_minus_5
member entity reference: Mitogen-activated protein kinase kinase kinase 2
member entity reference: Uncharacterized protein
member entity reference: Mitogen-activated protein kinase kinase kinase 5
member entity reference: Mitogen-activated protein kinase kinase kinase 4
member entity reference: Mitogen-activated protein kinase kinase kinase 1
member entity reference: Mitogen-activated protein kinase kinase kinase nsy-1
member entity reference: Apoptotic signal-regulating kinase 1, isoform C
member entity reference: Mitogen-activated protein kinase kinase kinase 3 isoform 1
member entity reference: Mitogen-activated protein kinase kinase kinase 3
member entity reference: Mitogen-activated protein kinase kinase kinase 6
member entity reference: Map3k3 protein
member entity reference: MAP3K2 isoform 1
member entity reference: MAP3K5 isoform 1

Protein kinase C delta type
type: ProteinReference
xref: uniprot Q05655 1183
xref: PTHR24356:SF365
organism: Homo sapiens

Daphnia pulex
type: BioSource
xref: ncbitaxon 6669 159

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: PTHR46559:SF1
xref: uniprot F1Q3J6 1114
organism: Canis lupus familiaris

uniprot Q0D2F4 528
type: UnificationXref
id: Q0D2F4
db: uniprot

Fibroblast growth factor 17
type: ProteinReference
xref: uniprot P63076 109
xref: PTHR11486:SF71
organism: Rattus norvegicus

Fibroblast growth factor 17
type: ProteinReference
xref: PTHR11486:SF71
xref: uniprot P63075 108
organism: Mus musculus

MAP2K4 isoform 3
type: ProteinReference
xref: PTHR48013:SF20
xref: uniprot H2QCA7 830
organism: Pan troglodytes

14-3-3 protein zeta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot Q6P4Z5 255
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot F1PBL1 161
organism: Canis lupus familiaris

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
type: ProteinReference
xref: PTHR10048:SF28
xref: uniprot Q61194 927
organism: Mus musculus

uniprot F7GN93 376
type: UnificationXref
id: F7GN93
db: uniprot

uniprot H2Q383 904
type: UnificationXref
id: H2Q383
db: uniprot

uniprot F6XW91 173
type: UnificationXref
id: F6XW91
db: uniprot

uniprot Q7QCP8 1191
type: UnificationXref
id: Q7QCP8
db: uniprot

PI3K
type: Protein
entity reference: PI3K
feature: COMPLEX PARTICIPANT BINDING FEATURE s17 sa9 1211
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F6PKB8 454
type: UnificationXref
id: F6PKB8
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__PKC-RIGHT__PKC-_r6
controller: Complex (FGFR1-4/PLC_gamma/ RasGAP/PI3K/ FRS2/SHP2/ SHC/Grb2/ SOS)

GTPase HRas isoform 1
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot F7F5K9 702
organism: Macaca mulatta

uniprot A0A3S5ZPX3 960
type: UnificationXref
id: A0A3S5ZPX3
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F7C5Z9 467
xref: PTHR10257:SF89
organism: Monodelphis domestica

Serine/threonine-protein kinase akt-1
type: ProteinReference
xref: uniprot Q17941 680
xref: PTHR24356:SF333
organism: Caenorhabditis elegans

PTHR21258:SF40
type: RelationshipXref
id: PTHR21258:SF40
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor
type: ProteinReference
xref: uniprot E2REX2 21
xref: PTHR11486:SF25
organism: Canis lupus familiaris

Putative serine/threonine-protein phosphatase C26H8.05c
type: ProteinReference
xref: uniprot O74789 491
organism: Schizosaccharomyces pombe

Fibroblast growth factor 2
type: ProteinReference
xref: uniprot P15655 86
xref: PTHR11486:SF83
organism: Mus musculus

uniprot F7HLC7 901
type: UnificationXref
id: F7HLC7
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F0ZDS0 441
organism: Dictyostelium purpureum

uniprot Q60996 559
type: UnificationXref
id: Q60996
db: uniprot

uniprot F7EPN2 1099
type: UnificationXref
id: F7EPN2
db: uniprot

Fibroblast growth factor 5
type: ProteinReference
xref: uniprot P15656 87
xref: PTHR11486:SF23
organism: Mus musculus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F1PS03 844
xref: PTHR10336:SF173
organism: Canis lupus familiaris

uniprot Q9VI08 642
type: UnificationXref
id: Q9VI08
db: uniprot

uniprot Q62925 763
type: UnificationXref
id: Q62925
db: uniprot

Serine/threonine-protein phosphatase PP2A-3 catalytic subunit
type: ProteinReference
xref: uniprot Q07100 526
organism: Arabidopsis thaliana

uniprot G5EDR3 478
type: UnificationXref
id: G5EDR3
db: uniprot

uniprot F5HM76 617
type: UnificationXref
id: F5HM76
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
type: ProteinReference
xref: uniprot Q6NY64 566
xref: PTHR11871:SF6
organism: Danio rerio

STATE_TRANSITION_LEFT__MKK3,6-RIGHT__MKK3,6-_r25
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1276
participant stoichiometry: PARTICIPANT STOICHIOMETRY r25 1277
left: MKK3,6
interaction type: STATE_TRANSITION
right: MKK3,6

AGAP002729-PA
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot Q7QCN5 1107
organism: Anopheles gambiae

uniprot E9H8M4 160
type: UnificationXref
id: E9H8M4
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__FGFR1_4-RIGHT__FGFR1_4-_r17
controller: FGF

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
type: ProteinReference
xref: uniprot A0A0G2K344 869
xref: PTHR10048:SF107
organism: Rattus norvegicus

uniprot P54675 924
type: UnificationXref
id: P54675
db: uniprot

uniprot Q01986 970
type: UnificationXref
id: Q01986
db: uniprot

uniprot P10767 81
type: UnificationXref
id: P10767
db: uniprot

14-3-3 protein theta
type: ProteinReference
xref: uniprot Q5ZMD1 252
xref: PTHR18860:SF3
organism: Gallus gallus

Serine/threonine-protein phosphatase PP2A-like PPG1
type: ProteinReference
xref: PTHR45619:SF6
xref: uniprot P32838 502
organism: Saccharomyces cerevisiae

Protein kinase C beta type
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot A8KBH6 1131
organism: Xenopus tropicalis

Mitogen-activated protein kinase kinase kinase 6
type: ProteinReference
xref: uniprot D3ZFL3 737
organism: Rattus norvegicus

Grb2
type: Protein
entity reference: Grb2
feature: ACTIVE 287
feature: COMPLEX PARTICIPANT BINDING FEATURE s41 sa16 1203
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein rasB
type: ProteinReference
xref: PTHR24070:SF206
xref: uniprot F0ZI47 695
organism: Dictyostelium purpureum

PARTICIPANT STOICHIOMETRY r11 1267
type: Stoichiometry
physical entity: RKIP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 1266
type: Stoichiometry
physical entity: RKIP
stoichiometric coefficient: 1.0

uniprot A0A3Q1MK31 1092
type: UnificationXref
id: A0A3Q1MK31
db: uniprot

ncbitaxon 227321 240
type: UnificationXref
id: 227321
db: ncbitaxon

Uncharacterized protein rasG
type: ProteinReference
xref: PTHR24070:SF17
xref: uniprot F0ZWE6 697
organism: Dictyostelium purpureum

uniprot Q9DFC9 125
type: UnificationXref
id: Q9DFC9
db: uniprot

uniprot F0ZWE6 697
type: UnificationXref
id: F0ZWE6
db: uniprot

STATE_TRANSITION_LEFT__GDP-_Ras-RIGHT__Ras-_GTP-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1270
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1271
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1269
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 1268
left: Ras
left: GDP
interaction type: STATE_TRANSITION
right: Ras
right: GTP

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F1Q3M8 888
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F0ZDQ6 440
organism: Dictyostelium purpureum

Uncharacterized protein
type: ProteinReference
xref: uniprot Q5ZIF0 978
xref: PTHR48013:SF5
organism: Gallus gallus

uniprot Q28EW2 725
type: UnificationXref
id: Q28EW2
db: uniprot

uniprot P34722 1169
type: UnificationXref
id: P34722
db: uniprot

PP2A
type: Protein
entity reference: PP2A
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot F0ZQR3 1045
type: UnificationXref
id: F0ZQR3
db: uniprot

Raf-1
type: ProteinReference
xref: P00643
standard name: RAF proto-oncogene serine/threonine-protein kinase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: RAF proto-oncogene serine/threonine-protein kinase Synonym: C-Raf,MAP kinase kinase kinase,Raf-1 Accession: P00643
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.Raf_minus_1
member entity reference: RAF proto-oncogene serine/threonine-protein kinase
member entity reference: Raf-1 proto-oncogene, serine/threonine kinase
member entity reference: Serine/threonine-protein kinase A-Raf
member entity reference: Uncharacterized protein
member entity reference: A-Raf proto-oncogene, serine/threonine kinase

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot C3XQF4 431
xref: PTHR45619:SF12
organism: Branchiostoma floridae

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot H9FVU5 906
xref: PTHR10048:SF107
organism: Macaca mulatta

uniprot P05129 1156
type: UnificationXref
id: P05129
db: uniprot

PTHR23113:SF150
type: RelationshipXref
id: PTHR23113:SF150
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36507 969
organism: Homo sapiens

Dual specificity mitogen-activated protein kinase kinase 2
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot P36506 968
organism: Rattus norvegicus

Serine/threonine protein phosphatase 2A regulatory subunit B''beta
type: ProteinReference
xref: uniprot Q5QIT3 556
organism: Arabidopsis thaliana

uniprot F1MY94 446
type: UnificationXref
id: F1MY94
db: uniprot

uniprot F1P859 941
type: UnificationXref
id: F1P859
db: uniprot

14-3-3 protein gamma-1
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot Q6PC29 256
organism: Danio rerio

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF240
xref: uniprot Q7QCP8 1191
organism: Anopheles gambiae

Protein kinase C
type: ProteinReference
xref: uniprot F7BYI4 1145
xref: PTHR24356:SF158
organism: Macaca mulatta

HETERODIMER_ASSOCIATION
type: RelationshipTypeVocabulary

uniprot K7CDC2 674
type: UnificationXref
id: K7CDC2
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot H2Q8X8 481
xref: PTHR10257:SF19
organism: Pan troglodytes

uniprot E9I1I7 693
type: UnificationXref
id: E9I1I7
db: uniprot

PTHR48013:SF8
type: RelationshipXref
id: PTHR48013:SF8
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 5
type: ProteinReference
xref: PTHR11584:SF332
xref: uniprot O35099 757
organism: Mus musculus

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
type: ProteinReference
xref: PTHR11871:SF1
xref: uniprot Q5E9Q7 555
organism: Bos taurus

STATE_TRANSITION_LEFT__p38-RIGHT__p38-_r26
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1274
participant stoichiometry: PARTICIPANT STOICHIOMETRY r26 1275
left: p38
interaction type: STATE_TRANSITION
right: p38

uniprot C4M0F4 152
type: UnificationXref
id: C4M0F4
db: uniprot

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
type: ProteinReference
xref: uniprot F6Y841 894
xref: PTHR10048:SF33
organism: Canis lupus familiaris

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot D3ZFJ0 878
organism: Rattus norvegicus

Emericella nidulans
type: BioSource
xref: ncbitaxon 227321 240

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF16
xref: uniprot F6WA79 170
organism: Monodelphis domestica

PTHR48013:SF5
type: RelationshipXref
id: PTHR48013:SF5
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot A0A1D5QYN7 786
organism: Macaca mulatta

uniprot Q7QK91 730
type: UnificationXref
id: Q7QK91
db: uniprot

uniprot A0A1D5QTA0 7
type: UnificationXref
id: A0A1D5QTA0
db: uniprot

uniprot E7EXT6 663
type: UnificationXref
id: E7EXT6
db: uniprot

uniprot H2QR74 1101
type: UnificationXref
id: H2QR74
db: uniprot

Ras-related C3 botulinum toxin substrate 1
type: ProteinReference
xref: uniprot P62999 1062
xref: PTHR24072:SF105
organism: Canis lupus familiaris

14-3-3 protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot F6XLR8 172
organism: Macaca mulatta

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot H2Q411 479
xref: PTHR10257:SF4
organism: Pan troglodytes

Fibroblast growth factor
type: ProteinReference
xref: uniprot G3V7X1 53
xref: PTHR11486:SF67
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF2
xref: uniprot A0A2I3RTP7 401
organism: Pan troglodytes

uniprot F6SW23 889
type: UnificationXref
id: F6SW23
db: uniprot

uniprot F7HFE8 749
type: UnificationXref
id: F7HFE8
db: uniprot

uniprot A0A3Q1LTT9 1004
type: UnificationXref
id: A0A3Q1LTT9
db: uniprot

uniprot Q02750 971
type: UnificationXref
id: Q02750
db: uniprot

uniprot Q9XGU0 1089
type: UnificationXref
id: Q9XGU0
db: uniprot

ncbitaxon 39947 234
type: UnificationXref
id: 39947
db: ncbitaxon

uniprot Q1K8E8 543
type: UnificationXref
id: Q1K8E8
db: uniprot

uniprot H2R8L2 859
type: UnificationXref
id: H2R8L2
db: uniprot

uniprot G2HDV2 52
type: UnificationXref
id: G2HDV2
db: uniprot

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63103 223
organism: Bos taurus

14-3-3 protein zeta/delta
type: ProteinReference
xref: uniprot P63104 224
xref: PTHR18860:SF7
organism: Homo sapiens

Uncharacterized protein rasS
type: ProteinReference
xref: PTHR24070:SF380
xref: uniprot F0ZVH9 696
organism: Dictyostelium purpureum

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot F6SW23 889
xref: PTHR10048:SF107
organism: Gallus gallus

uniprot A0A1D5RHD1 269
type: UnificationXref
id: A0A1D5RHD1
db: uniprot

Fibroblast growth factor receptor 4
type: ProteinReference
xref: PTHR24416:SF343
xref: uniprot Q90413 818
organism: Danio rerio

Phosphatidylinositol 3-kinase vps34
type: ProteinReference
xref: uniprot P50520 921
xref: PTHR10048:SF7
organism: Schizosaccharomyces pombe

Evidence 994
type: Evidence
evidence code: IGI
comment: SPACC P04049

Evidence 999
type: Evidence
evidence code: IGI
comment: SPACC P11345

GTP
type: SmallMolecule
cellular location: cytoplasm
comment: SPECIES_TYPE=SIMPLE_MOLECULE

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A3Q1MMD9 841
xref: PTHR10336:SF25
organism: Bos taurus

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63102 222
organism: Rattus norvegicus

Mitogen-activated protein kinase 11
type: ProteinReference
xref: uniprot Q9WUI1 1034
xref: PTHR24055:SF109
organism: Mus musculus

14-3-3 protein zeta/delta
type: ProteinReference
xref: PTHR18860:SF7
xref: uniprot P63101 221
organism: Mus musculus

uniprot Q5K8Z6 244
type: UnificationXref
id: Q5K8Z6
db: uniprot

Mitogen-activated protein kinase kinase kinase 4
type: ProteinReference
xref: uniprot Q9Y6R4 769
xref: PTHR48016:SF32
organism: Homo sapiens

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__JNK1_3-RIGHT__JNK1_3-_r24
controller: MKK4,7

uniprot Q9XW79 606
type: UnificationXref
id: Q9XW79
db: uniprot

uniprot F6ZTS0 1012
type: UnificationXref
id: F6ZTS0
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q5M824 864
xref: PTHR10337:SF2
organism: Rattus norvegicus

Mitogen-activated protein kinase p38a
type: ProteinReference
xref: uniprot O62618 1019
xref: PTHR24055:SF238
organism: Drosophila melanogaster

Evidence 1002
type: Evidence
evidence code: IGI
comment: SPACC Q99N57

14-3-3 protein theta
type: ProteinReference
xref: PTHR18860:SF3
xref: uniprot P68255 228
organism: Rattus norvegicus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot Q7ZVK8 354
xref: PTHR24055:SF393
organism: Danio rerio

14-3-3 protein theta
type: ProteinReference
xref: uniprot P68254 227
xref: PTHR18860:SF3
organism: Mus musculus

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 197

Raf 1 s24 a27 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=2.5581540179231173

SOS Ras/Rho guanine nucleotide exchange factor 2
type: ProteinReference
xref: PTHR23113:SF150
xref: uniprot F6URW3 944
organism: Ornithorhynchus anatinus

Evidence 986
type: Evidence
evidence code: ISS
comment: SPACC Q99N57

Evidence 985
type: Evidence
evidence code: ISS
comment: SPACC P11345

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 195

Ras GTPase-activating protein 4
type: ProteinReference
xref: PTHR10194:SF4
xref: uniprot O43374 1102
organism: Homo sapiens

Evidence 984
type: Evidence
evidence code: ISS
comment: SPACC P05625

Evidence 983
type: Evidence
evidence code: ISS
comment: SPACC P04049

Uncharacterized protein
type: ProteinReference
xref: uniprot F7H4H9 182
xref: PTHR18860:SF3
organism: Macaca mulatta

uniprot F7GWY6 50
type: UnificationXref
id: F7GWY6
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
type: ProteinReference
xref: uniprot Q22070 852
organism: Caenorhabditis elegans

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
type: ProteinReference
xref: uniprot F1PKW7 162
xref: PTHR18860:SF28
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase 4 catalytic subunit A
type: ProteinReference
xref: uniprot A8WGP3 418
organism: Danio rerio

uniprot E2REI6 989
type: UnificationXref
id: E2REI6
db: uniprot

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot P68250 225
organism: Bos taurus

uniprot F1Q3M8 888
type: UnificationXref
id: F1Q3M8
db: uniprot

SOS
type: Protein
entity reference: SOS
feature: ACTIVE 287
feature: COMPLEX PARTICIPANT BINDING FEATURE s36 sa14 1221
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q08BT6 1184
type: UnificationXref
id: Q08BT6
db: uniprot

Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
type: ProteinReference
xref: uniprot Q0DBD3 529
organism: Oryza sativa

INHIBITION
type: Control
xref: INHIBITION
controlled: STATE_TRANSITION_LEFT__Raf_1-RIGHT__Raf_1-_r8
control type: INHIBITION
controller: RKIP

uniprot Q02195 115
type: UnificationXref
id: Q02195
db: uniprot

uniprot H2QAS6 1150
type: UnificationXref
id: H2QAS6
db: uniprot

14-3-3 protein sigma
type: ProteinReference
xref: PTHR18860:SF14
xref: uniprot G7MHX1 184
organism: Macaca mulatta

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
type: ProteinReference
xref: uniprot P38903 508
organism: Saccharomyces cerevisiae

uniprot Q9TXI7 936
type: UnificationXref
id: Q9TXI7
db: uniprot

Ras GTPase-activating protein 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot P50904 1105
organism: Rattus norvegicus

Mitogen-activated protein kinase KSS1
type: ProteinReference
xref: uniprot P14681 332
organism: Saccharomyces cerevisiae

STATE_TRANSITION_LEFT__MEK1_2-RIGHT__MEK1_2-_r9
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 1256
participant stoichiometry: PARTICIPANT STOICHIOMETRY r9 1257
left: MEK1-2
interaction type: STATE_TRANSITION
right: MEK1-2

Raf 1 s24 a27 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.8069631906872994

uniprot E2RKA7 1007
type: UnificationXref
id: E2RKA7
db: uniprot

uniprot Q2R2W2 237
type: UnificationXref
id: Q2R2W2
db: uniprot

PTHR24361:SF656
type: RelationshipXref
id: PTHR24361:SF656
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF27
xref: uniprot F7GWY6 50
organism: Macaca mulatta

uniprot Q6Z437 352
type: UnificationXref
id: Q6Z437
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5PXC6 362
xref: PTHR24055:SF162
organism: Gallus gallus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot Q7TNL5 578
organism: Mus musculus

STATE_TRANSITION_LEFT__ERK1_2-RIGHT__ERK1_2-_r14
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 1262
participant stoichiometry: PARTICIPANT STOICHIOMETRY r14 1263
left: ERK1-2
interaction type: STATE_TRANSITION
right: ERK1-2

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A8X1S0 367
organism: Caenorhabditis briggsae

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 149

uniprot P48736 920
type: UnificationXref
id: P48736
db: uniprot

uniprot A0A2I3RTP7 401
type: UnificationXref
id: A0A2I3RTP7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot E2RQM0 843
xref: PTHR10336:SF25
organism: Canis lupus familiaris

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot P53349 759
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR10194:SF21
xref: uniprot A0A1D5QAB6 1090
organism: Macaca mulatta

Fibroblast growth factor
type: ProteinReference
xref: uniprot F7A1B0 42
organism: Macaca mulatta

By Homology
type: RelationshipTypeVocabulary

uniprot Q6K4K9 565
type: UnificationXref
id: Q6K4K9
db: uniprot

uniprot F7F2X9 47
type: UnificationXref
id: F7F2X9
db: uniprot

PTHR11584:SF391
type: RelationshipXref
id: PTHR11584:SF391
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase 1
type: ProteinReference
xref: PTHR48013:SF5
xref: uniprot Q66JE6 980
organism: Xenopus tropicalis

uniprot O54769 72
type: UnificationXref
id: O54769
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot Q6P023 351
organism: Danio rerio

Tyrosine-protein phosphatase non-receptor type 6
type: ProteinReference
xref: uniprot P29350 1121
xref: PTHR46257:SF4
organism: Homo sapiens

Tyrosine-protein phosphatase non-receptor type 6
type: ProteinReference
xref: uniprot P29351 1122
xref: PTHR46257:SF4
organism: Mus musculus

uniprot F7DJK6 777
type: UnificationXref
id: F7DJK6
db: uniprot

SHC-transforming protein 1
type: ProteinReference
xref: PTHR10337:SF2
xref: uniprot P29353 861
organism: Homo sapiens

uniprot Q90413 818
type: UnificationXref
id: Q90413
db: uniprot

ncbitaxon 9031 4
type: UnificationXref
id: 9031
db: ncbitaxon

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
type: ProteinReference
xref: uniprot P63151 517
xref: PTHR11871:SF2
organism: Homo sapiens

Sex muscle abnormal protein 5
type: ProteinReference
xref: PTHR46037:SF1
xref: uniprot P29355 650
organism: Caenorhabditis elegans

uniprot Q8CIH5 854
type: UnificationXref
id: Q8CIH5
db: uniprot

uniprot A0A2I3RQJ8 1128
type: UnificationXref
id: A0A2I3RQJ8
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F1P630 368
organism: Canis lupus familiaris

uniprot O02812 1014
type: UnificationXref
id: O02812
db: uniprot

uniprot F7CP86 468
type: UnificationXref
id: F7CP86
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: PTHR24356:SF192
xref: uniprot P23298 1165
organism: Mus musculus

uniprot P67774 520
type: UnificationXref
id: P67774
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q5CZQ1 241
organism: Danio rerio

FGFR1-4
type: Protein
entity reference: FGFR1-4
feature: FGFR1 4 s1 sa1 rs3
feature: ACTIVE 287
feature: FGFR1 4 s1 sa1 rs2
feature: FGFR1 4 s1 sa1 rs1
feature: FGFR1 4 s1 sa1 rs4

uniprot F6QE96 667
type: UnificationXref
id: F6QE96
db: uniprot

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 17

uniprot Q67VP4 1075
type: UnificationXref
id: Q67VP4
db: uniprot

uniprot F1P8X1 450
type: UnificationXref
id: F1P8X1
db: uniprot

uniprot A0A0G2K3R1 732
type: UnificationXref
id: A0A0G2K3R1
db: uniprot

uniprot D3ZJA3 292
type: UnificationXref
id: D3ZJA3
db: uniprot

Fibroblast growth factor 1
type: ProteinReference
xref: uniprot F7DY09 44
xref: PTHR11486:SF86
organism: Macaca mulatta

uniprot Q90XF2 1192
type: UnificationXref
id: Q90XF2
db: uniprot

uniprot F0ZDJ1 438
type: UnificationXref
id: F0ZDJ1
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9LQQ9 358
organism: Arabidopsis thaliana

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot A0A3Q1M739 1112
xref: PTHR46257:SF4
organism: Bos taurus

uniprot C8V7D1 318
type: UnificationXref
id: C8V7D1
db: uniprot

Tyrosine-protein phosphatase corkscrew
type: ProteinReference
xref: uniprot P29349 1120
organism: Drosophila melanogaster

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF25
xref: uniprot Q8R5L5 119
organism: Rattus norvegicus

Fibroblast growth factor 14
type: ProteinReference
xref: uniprot Q8R5L7 120
organism: Rattus norvegicus

STATE_TRANSITION_LEFT__Spry-RIGHT__Spry-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 1272
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 1273
left: Spry
interaction type: STATE_TRANSITION
right: Spry

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot H2R0G7 378
organism: Pan troglodytes

MKK4,7
type: Protein
entity reference: MKK4,7
feature: MKK4,7 s39 a41 rs2
feature: MKK4,7 s39 a41 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Tyrosine-protein phosphatase non-receptor type
type: ProteinReference
xref: uniprot A0A1D5QYU2 1110
xref: PTHR46559:SF1
organism: Macaca mulatta

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A1D5R393 397
organism: Macaca mulatta

FGFR1 4 s1 sa1 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 2.0

uniprot Q9PTL2 309
type: UnificationXref
id: Q9PTL2
db: uniprot

Grb2
type: Protein
entity reference: Grb2
feature: COMPLEX PARTICIPANT BINDING FEATURE s5 sa4 1223
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Phosphatidylethanolamine-binding protein 2
type: ProteinReference
xref: uniprot Q8VIN1 632
organism: Mus musculus

Phosphatidylinositol 3-kinase catalytic subunit type 3
type: ProteinReference
xref: uniprot F6VAQ8 891
xref: PTHR10048:SF7
organism: Ornithorhynchus anatinus

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot Q925D6 286
organism: Rattus norvegicus

uniprot O42766 189
type: UnificationXref
id: O42766
db: uniprot

Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit
type: ProteinReference
xref: uniprot P36179 503
organism: Drosophila melanogaster

uniprot Q6PF93 928
type: UnificationXref
id: Q6PF93
db: uniprot

Rac-like GTP-binding protein 2
type: ProteinReference
xref: uniprot Q68Y52 1076
xref: PTHR24072:SF127
organism: Oryza sativa

Grb2 s5 sa4 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

Fibroblast growth factor
type: ProteinReference
xref: uniprot B7UCP9 18
xref: PTHR11486:SF72
organism: Xenopus tropicalis

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: uniprot A0A2I3T7A8 873
xref: PTHR10048:SF107
organism: Pan troglodytes

uniprot H2Q6Z4 619
type: UnificationXref
id: H2Q6Z4
db: uniprot

eco ECO:0000303 319
type: UnificationXref
id: ECO:0000303
db: eco

PTHR18860:SF115
type: RelationshipXref
id: PTHR18860:SF115
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF112
type: RelationshipXref
id: PTHR18860:SF112
db: PANTHER Family
relationship type: By Homology

Protein kinase C
type: ProteinReference
xref: uniprot E1BMG4 1133
xref: PTHR24356:SF181
organism: Bos taurus

14-3-3-like protein GF14 omicron
type: ProteinReference
xref: uniprot Q9S9Z8 268
xref: PTHR18860:SF31
organism: Arabidopsis thaliana

uniprot A0A3Q1MSP9 1130
type: UnificationXref
id: A0A3Q1MSP9
db: uniprot

uniprot G5EC24 1117
type: UnificationXref
id: G5EC24
db: uniprot

uniprot Q9SV41 599
type: UnificationXref
id: Q9SV41
db: uniprot

Protein kinase C eta type
type: ProteinReference
xref: uniprot P24723 1167
xref: PTHR24356:SF192
organism: Homo sapiens

uniprot B7Q5I4 146
type: UnificationXref
id: B7Q5I4
db: uniprot

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot P49186 381
organism: Rattus norvegicus

uniprot Q2QXL9 627
type: UnificationXref
id: Q2QXL9
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TKL3 370
organism: Xenopus tropicalis

Mitogen-activated protein kinase 10
type: ProteinReference
xref: uniprot P49187 382
xref: PTHR24055:SF162
organism: Rattus norvegicus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot F7E5M4 472
organism: Ornithorhynchus anatinus

uniprot D3ZFJ0 878
type: UnificationXref
id: D3ZFJ0
db: uniprot

uniprot P42645 205
type: UnificationXref
id: P42645
db: uniprot

uniprot A0A2I3SHP7 840
type: UnificationXref
id: A0A2I3SHP7
db: uniprot

SOS
type: ProteinReference
xref: P00641
standard name: Son of sevenless
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: SOS Synonym: Synonym not specified Accession: P00641
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.SOS
member entity reference: SOS Ras/Rac guanine nucleotide exchange factor 1
member entity reference: Son of sevenless homolog 2
member entity reference: Ras guanine nucleotide exchange factor B
member entity reference: Son of sevenless homolog 1
member entity reference: Ras guanine nucleotide exchange factor A
member entity reference: Ras guanine nucleotide exchange factor Y
member entity reference: Protein son of sevenless
member entity reference: Ras guanine nucleotide exchange factor R
member entity reference: SOS Ras/Rho guanine nucleotide exchange factor 2
member entity reference: Uncharacterized protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
type: ProteinReference
xref: uniprot Q925E7 592
organism: Mus musculus

uniprot Q9D9G2 636
type: UnificationXref
id: Q9D9G2
db: uniprot

PARTICIPANT STOICHIOMETRY r31 1245
type: Stoichiometry
physical entity: Complex (Grb2/SOS)
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r31 1244
type: Stoichiometry
physical entity: SOS
stoichiometric coefficient: 1.0

PTHR18860:SF106
type: RelationshipXref
id: PTHR18860:SF106
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r31 1243
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

uniprot P81718 1125
type: UnificationXref
id: P81718
db: uniprot

PTHR10257:SF3
type: RelationshipXref
id: PTHR10257:SF3
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF101
type: RelationshipXref
id: PTHR18860:SF101
db: PANTHER Family
relationship type: By Homology

PTHR10257:SF4
type: RelationshipXref
id: PTHR10257:SF4
db: PANTHER Family
relationship type: By Homology

Dual specificity mitogen-activated protein kinase kinase dSOR1
type: ProteinReference
xref: uniprot Q24324 975
xref: PTHR48013:SF19
organism: Drosophila melanogaster

PTHR10257:SF5
type: RelationshipXref
id: PTHR10257:SF5
db: PANTHER Family
relationship type: By Homology

PTHR18860:SF103
type: RelationshipXref
id: PTHR18860:SF103
db: PANTHER Family
relationship type: By Homology

PTHR10257:SF6
type: RelationshipXref
id: PTHR10257:SF6
db: PANTHER Family
relationship type: By Homology

uniprot P10398 997
type: UnificationXref
id: P10398
db: uniprot

PTHR10337:SF11
type: RelationshipXref
id: PTHR10337:SF11
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot A0A1D5R2V9 787
xref: PTHR24416:SF131
organism: Macaca mulatta

PTHR18860:SF109
type: RelationshipXref
id: PTHR18860:SF109
db: PANTHER Family
relationship type: By Homology

uniprot A0A1D5QJY6 872
type: UnificationXref
id: A0A1D5QJY6
db: uniprot

14-3-3 protein theta
type: ProteinReference
xref: uniprot Q3SZI4 238
xref: PTHR18860:SF3
organism: Bos taurus

Fibroblast growth factor 10
type: ProteinReference
xref: uniprot P70492 113
xref: PTHR11486:SF21
organism: Rattus norvegicus

uniprot Q5ANK2 1186
type: UnificationXref
id: Q5ANK2
db: uniprot

Mitogenesis Differentiation
type: Pathway

uniprot F7GLY8 279
type: UnificationXref
id: F7GLY8
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
type: ProteinReference
xref: PTHR18860:SF3
xref: uniprot H2QHF1 185
organism: Pan troglodytes

uniprot P47197 679
type: UnificationXref
id: P47197
db: uniprot

uniprot F7BD74 277
type: UnificationXref
id: F7BD74
db: uniprot

ncbitaxon 7739 432
type: UnificationXref
id: 7739
db: ncbitaxon

uniprot D4A3U7 1006
type: UnificationXref
id: D4A3U7
db: uniprot

uniprot F7HSM1 477
type: UnificationXref
id: F7HSM1
db: uniprot

SHC adaptor protein 3
type: ProteinReference
xref: uniprot F1PPW0 857
xref: PTHR10337:SF4
organism: Canis lupus familiaris

uniprot F7FDA0 898
type: UnificationXref
id: F7FDA0
db: uniprot

uniprot E1B7I9 774
type: UnificationXref
id: E1B7I9
db: uniprot

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
type: ProteinReference
xref: uniprot F7DY42 179
xref: PTHR18860:SF17
organism: Xenopus tropicalis

uniprot P34145 1055
type: UnificationXref
id: P34145
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot F6NSV0 28
organism: Danio rerio

uniprot F6WY95 40
type: UnificationXref
id: F6WY95
db: uniprot

uniprot P05130 1157
type: UnificationXref
id: P05130
db: uniprot

Rac
type: Protein
entity reference: Rac
feature: ACTIVE 287
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot P05230 78
type: UnificationXref
id: P05230
db: uniprot

uniprot F1MSX4 741
type: UnificationXref
id: F1MSX4
db: uniprot

uniprot H2QLB4 329
type: UnificationXref
id: H2QLB4
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF18
xref: uniprot B7U3Y1 16
organism: Xenopus tropicalis

Fibroblast growth factor
type: ProteinReference
xref: uniprot F6RAU4 34
xref: PTHR11486:SF77
organism: Ornithorhynchus anatinus

Rac-like GTP-binding protein ARAC3
type: ProteinReference
xref: uniprot Q38912 1072
organism: Arabidopsis thaliana

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ERK1_2-RIGHT__ERK1_2-_r14
controller: MEK1-2

PTHR48013:SF15
type: RelationshipXref
id: PTHR48013:SF15
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor receptor 1
type: ProteinReference
xref: uniprot Q04589 814
xref: PTHR24416:SF131
organism: Rattus norvegicus

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot A0A3Q1LUE0 791
xref: PTHR24416:SF131
organism: Bos taurus

AGAP002049-PA
type: ProteinReference
xref: uniprot Q380S1 628
organism: Anopheles gambiae

PTHR48013:SF19
type: RelationshipXref
id: PTHR48013:SF19
db: PANTHER Family
relationship type: By Homology

Protein BMH1
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot P29311 196
organism: Saccharomyces cerevisiae

14-3-3 protein zeta
type: ProteinReference
xref: uniprot P29310 194
xref: PTHR18860:SF106
organism: Drosophila melanogaster

RAC-beta serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF176
xref: uniprot P31751 677
organism: Homo sapiens

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31750 676
organism: Mus musculus

PTHR24356:SF240
type: RelationshipXref
id: PTHR24356:SF240
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor receptor 1
type: ProteinReference
xref: uniprot P21804 810
xref: PTHR24416:SF131
organism: Gallus gallus

Fibroblast growth factor receptor 2
type: ProteinReference
xref: PTHR24416:SF130
xref: uniprot P21803 809
organism: Mus musculus

Fibroblast growth factor receptor 2
type: ProteinReference
xref: PTHR24416:SF130
xref: uniprot P21802 808
organism: Homo sapiens

Bos taurus
type: BioSource
xref: ncbitaxon 9913 15

RAC-gamma serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q9WUA6 685
xref: PTHR24356:SF190
organism: Mus musculus

uniprot O15264 1016
type: UnificationXref
id: O15264
db: uniprot

uniprot P34144 1054
type: UnificationXref
id: P34144
db: uniprot

uniprot F6VXG1 892
type: UnificationXref
id: F6VXG1
db: uniprot

uniprot F7GJG7 649
type: UnificationXref
id: F7GJG7
db: uniprot

PTHR18860:SF125
type: RelationshipXref
id: PTHR18860:SF125
db: PANTHER Family
relationship type: By Homology

uniprot P36877 507
type: UnificationXref
id: P36877
db: uniprot

PTHR48013:SF21
type: RelationshipXref
id: PTHR48013:SF21
db: PANTHER Family
relationship type: By Homology

Rac-like GTP-binding protein ARAC1
type: ProteinReference
xref: PTHR24072:SF179
xref: uniprot Q38902 1070
organism: Arabidopsis thaliana

PTHR48013:SF20
type: RelationshipXref
id: PTHR48013:SF20
db: PANTHER Family
relationship type: By Homology

Rac-like GTP-binding protein ARAC2
type: ProteinReference
xref: uniprot Q38903 1071
xref: PTHR24072:SF300
organism: Arabidopsis thaliana

RAC-alpha serine/threonine-protein kinase
type: ProteinReference
xref: PTHR24356:SF171
xref: uniprot P31749 675
organism: Homo sapiens

Fibroblast growth factor
type: ProteinReference
xref: uniprot F7ELZ5 45
xref: PTHR11486:SF17
organism: Monodelphis domestica

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot F7BVQ1 846
xref: PTHR10336:SF25
organism: Monodelphis domestica

uniprot A0A2J8KPL7 12
type: UnificationXref
id: A0A2J8KPL7
db: uniprot

uniprot O97259 493
type: UnificationXref
id: O97259
db: uniprot

uniprot C3YJC1 1039
type: UnificationXref
id: C3YJC1
db: uniprot

uniprot P08556 711
type: UnificationXref
id: P08556
db: uniprot

14-3-3-like protein 2
type: ProteinReference
xref: uniprot Q20655 236
xref: PTHR18860:SF106
organism: Caenorhabditis elegans

uniprot F7G3I5 899
type: UnificationXref
id: F7G3I5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot A0A2I3RG08 856
xref: PTHR10337:SF4
organism: Pan troglodytes

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 147

uniprot A0A3Q1LPF2 734
type: UnificationXref
id: A0A3Q1LPF2
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
type: ProteinReference
xref: uniprot P08487 848
xref: PTHR10336:SF173
organism: Bos taurus

Protein kinase C
type: ProteinReference
xref: uniprot A0A2I3SR38 1129
xref: PTHR24356:SF181
organism: Pan troglodytes

PTHR24356:SF214
type: RelationshipXref
id: PTHR24356:SF214
db: PANTHER Family
relationship type: By Homology

14-3-3 protein 3
type: ProteinReference
xref: uniprot C4M0F4 152
xref: PTHR18860:SF106
organism: Entamoeba histolytica

AGAP001573-PA
type: ProteinReference
xref: uniprot Q380U3 1069
organism: Anopheles gambiae

uniprot H2Q9E4 59
type: UnificationXref
id: H2Q9E4
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F6X0X1 460
xref: PTHR10257:SF19
organism: Ornithorhynchus anatinus

uniprot F7E823 325
type: UnificationXref
id: F7E823
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F7GWP9 475
xref: PTHR10257:SF92
organism: Macaca mulatta

Fibroblast growth factor receptor
type: ProteinReference
xref: PTHR24416:SF343
xref: uniprot F1MN51 795
organism: Bos taurus

uniprot O43559 781
type: UnificationXref
id: O43559
db: uniprot

PTHR11362:SF109
type: RelationshipXref
id: PTHR11362:SF109
db: PANTHER Family
relationship type: By Homology

uniprot Q7QK56 682
type: UnificationXref
id: Q7QK56
db: uniprot

uniprot H2QNH9 1100
type: UnificationXref
id: H2QNH9
db: uniprot

RasGAP
type: Protein
entity reference: RasGAP
feature: COMPLEX PARTICIPANT BINDING FEATURE s16 sa8 1209
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Predicted protein
type: ProteinReference
xref: PTHR24070:SF420
xref: uniprot A7STP5 690
organism: Nematostella vectensis

Rac-like GTP-binding protein ARAC4
type: ProteinReference
xref: uniprot Q38919 1073
organism: Arabidopsis thaliana

Fibroblast growth factor
type: ProteinReference
xref: uniprot Q9I950 131
xref: PTHR11486:SF4
organism: Gallus gallus

uniprot Q552M5 955
type: UnificationXref
id: Q552M5
db: uniprot

Protein RICE FLOWERING LOCUS T 1
type: ProteinReference
xref: uniprot Q8VWH2 633
organism: Oryza sativa

RAC serine/threonine-protein kinase
type: ProteinReference
xref: uniprot Q8INB9 683
xref: PTHR24356:SF333
organism: Drosophila melanogaster

ERK1-2
type: Protein
entity reference: ERK1-2
feature: ERK1 2 s28 a31 rs1
feature: ACTIVE 287
feature: ERK1 2 s28 a31 rs2
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot A0A0G2K344 869
type: UnificationXref
id: A0A0G2K344
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__MKK3,6-RIGHT__MKK3,6-_r25
controller: MEKK1-5

Fibroblast growth factor receptor
type: ProteinReference
xref: PTHR24416:SF343
xref: uniprot F6XBX5 799
organism: Canis lupus familiaris

Gallus gallus
type: BioSource
xref: ncbitaxon 9031 4

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q6GLE6 564
xref: PTHR45619:SF44
organism: Xenopus tropicalis

uniprot Q23977 835
type: UnificationXref
id: Q23977
db: uniprot

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot C3ZG26 433
organism: Branchiostoma floridae

uniprot F1P9Z7 796
type: UnificationXref
id: F1P9Z7
db: uniprot

14-3-3 protein
type: ProteinReference
xref: PTHR18860:SF115
xref: uniprot A8JGV6 141
organism: Chlamydomonas reinhardtii

Fibroblast growth factor
type: ProteinReference
xref: uniprot J9P0B3 66
organism: Canis lupus familiaris

ncbitaxon 9544 8
type: UnificationXref
id: 9544
db: ncbitaxon

Ras-like protein
type: ProteinReference
xref: uniprot P0CQ42 715
xref: PTHR24070:SF17
organism: Cryptococcus neoformans

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot Q5PU49 1187
organism: Canis lupus familiaris

uniprot O61443 1018
type: UnificationXref
id: O61443
db: uniprot

Rac family small GTPase 1a
type: ProteinReference
xref: uniprot Q7ZSZ9 1085
xref: PTHR24072:SF105
organism: Danio rerio

uniprot Q8SSQ0 958
type: UnificationXref
id: Q8SSQ0
db: uniprot

Serine/threonine-protein kinase A-Raf
type: ProteinReference
xref: uniprot H9FU32 992
organism: Macaca mulatta

Protein phosphatase 2 scaffold subunit Aalpha
type: ProteinReference
xref: PTHR10648:SF2
xref: uniprot A0A2I3T2U1 403
organism: Pan troglodytes

uniprot P37237 94
type: UnificationXref
id: P37237
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR24070:SF388
xref: uniprot F7F5X1 703
organism: Monodelphis domestica

uniprot Q9N272 1032
type: UnificationXref
id: Q9N272
db: uniprot

uniprot F7HC75 1148
type: UnificationXref
id: F7HC75
db: uniprot

uniprot P08642 712
type: UnificationXref
id: P08642
db: uniprot

uniprot Q15172 539
type: UnificationXref
id: Q15172
db: uniprot

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
type: ProteinReference
xref: uniprot Q38950 548
organism: Arabidopsis thaliana

uniprot F7BYI4 1145
type: UnificationXref
id: F7BYI4
db: uniprot

uniprot Q74ZU1 258
type: UnificationXref
id: Q74ZU1
db: uniprot

uniprot A4FV00 366
type: UnificationXref
id: A4FV00
db: uniprot

uniprot J9P5W6 965
type: UnificationXref
id: J9P5W6
db: uniprot

14-3-3-like protein GF14-A
type: ProteinReference
xref: uniprot Q84J55 265
xref: PTHR18860:SF83
organism: Oryza sativa

uniprot E1C5A3 435
type: UnificationXref
id: E1C5A3
db: uniprot

uniprot Q6P023 351
type: UnificationXref
id: Q6P023
db: uniprot

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform
type: ProteinReference
xref: uniprot Q38951 549
organism: Arabidopsis thaliana

uniprot E1BQN6 1134
type: UnificationXref
id: E1BQN6
db: uniprot

uniprot P38903 508
type: UnificationXref
id: P38903
db: uniprot

Raf 1 s24 a27 rs3
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=5.662707240054924

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: uniprot Q8C180 782
xref: PTHR21258:SF40
organism: Mus musculus

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot F1P9Z7 796
xref: PTHR24416:SF505
organism: Canis lupus familiaris

PARTICIPANT STOICHIOMETRY r14 1263
type: Stoichiometry
physical entity: ERK1-2
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r14 1262
type: Stoichiometry
physical entity: ERK1-2
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot A0A1D5R6N7 398
xref: PTHR10257:SF19
organism: Macaca mulatta

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot E2RCV1 883
organism: Canis lupus familiaris

uniprot H2R5K3 753
type: UnificationXref
id: H2R5K3
db: uniprot

uniprot Q9VXH3 855
type: UnificationXref
id: Q9VXH3
db: uniprot

Phosphatidylethanolamine-binding protein homolog F40A3.3
type: ProteinReference
xref: uniprot O16264 620
organism: Caenorhabditis elegans

PTHR11584:SF332
type: RelationshipXref
id: PTHR11584:SF332
db: PANTHER Family
relationship type: By Homology

uniprot F7EFF6 180
type: UnificationXref
id: F7EFF6
db: uniprot

GTPase NRas
type: ProteinReference
xref: uniprot Q5F352 728
xref: PTHR24070:SF189
organism: Gallus gallus

uniprot Q39024 345
type: UnificationXref
id: Q39024
db: uniprot

uniprot P31371 91
type: UnificationXref
id: P31371
db: uniprot

uniprot P48807 99
type: UnificationXref
id: P48807
db: uniprot

uniprot Q6GLE6 564
type: UnificationXref
id: Q6GLE6
db: uniprot

Rac-like GTP-binding protein 1
type: ProteinReference
xref: PTHR24072:SF289
xref: uniprot Q9SSX0 1087
organism: Oryza sativa

Son of sevenless homolog 2
type: ProteinReference
xref: uniprot Q02384 951
xref: PTHR23113:SF150
organism: Mus musculus

Fibroblast growth factor
type: ProteinReference
xref: uniprot F7HFS0 51
organism: Macaca mulatta

uniprot P48802 98
type: UnificationXref
id: P48802
db: uniprot

Raf 1 s24 a27 rs4
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=0.6130914234684163

uniprot P70377 110
type: UnificationXref
id: P70377
db: uniprot

uniprot Q0IIE2 863
type: UnificationXref
id: Q0IIE2
db: uniprot

uniprot Q9SXZ2 639
type: UnificationXref
id: Q9SXZ2
db: uniprot

uniprot F7A0H3 175
type: UnificationXref
id: F7A0H3
db: uniprot

uniprot A0A2I3T7A8 873
type: UnificationXref
id: A0A2I3T7A8
db: uniprot

MKK3,6 s52 a65 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot P53779 383
type: UnificationXref
id: P53779
db: uniprot

Os01g0748800 protein
type: ProteinReference
xref: uniprot A0A0P0V857 614
organism: Oryza sativa

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: uniprot B5DE89 773
xref: PTHR21258:SF40
organism: Xenopus tropicalis

uniprot F7GAP5 900
type: UnificationXref
id: F7GAP5
db: uniprot

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot E1BQN6 1134
organism: Gallus gallus

Complex (FGFR1-4/PLC_gamma/ RasGAP/PI3K/ FRS2/SHP2/ SHC/Grb2/ SOS)
type: Complex
component stoichiometry: PLCgamma s15 sa7 STOICHIOMETRY ID COMPLEX
component stoichiometry: Grb2 s35 sa13 STOICHIOMETRY ID COMPLEX
component stoichiometry: SOS s36 sa14 STOICHIOMETRY ID COMPLEX
component stoichiometry: RasGAP s16 sa8 STOICHIOMETRY ID COMPLEX
component stoichiometry: FRS2 s18 sa10 STOICHIOMETRY ID COMPLEX
component stoichiometry: SHP2 s20 sa11 STOICHIOMETRY ID COMPLEX
component stoichiometry: PI3K s17 sa9 STOICHIOMETRY ID COMPLEX
component stoichiometry: SHC s32 sa12 STOICHIOMETRY ID COMPLEX
component: SHP2
component: SOS
component: FGFR1-4
component: PI3K
component: PLCgamma
component: SHC
component: Grb2
component: FRS2
component: RasGAP
feature: COMPLEX BINDING FEATURE s74 a95 1220
feature: COMPLEX BINDING FEATURE s74 a95 1208
feature: COMPLEX BINDING FEATURE s74 a95 1212
feature: COMPLEX BINDING FEATURE s74 a95 1204
feature: COMPLEX BINDING FEATURE s74 a95 1216
feature: COMPLEX BINDING FEATURE s74 a95 1210
feature: COMPLEX BINDING FEATURE s74 a95 1214
feature: COMPLEX BINDING FEATURE s74 a95 1206
feature: COMPLEX BINDING FEATURE s74 a95 1218
cellular location: cytoplasm

uniprot Q6ZHA3 1083
type: UnificationXref
id: Q6ZHA3
db: uniprot

Fibroblast growth factor 2
type: ProteinReference
xref: uniprot P13109 85
xref: PTHR11486:SF83
organism: Rattus norvegicus

PTHR11362:SF131
type: RelationshipXref
id: PTHR11362:SF131
db: PANTHER Family
relationship type: By Homology

Phytochrome-associated serine/threonine-protein phosphatase 3
type: ProteinReference
xref: uniprot Q9LHE7 595
organism: Arabidopsis thaliana

Non-specific serine/threonine protein kinase
type: ProteinReference
xref: uniprot F6R8N3 669
xref: PTHR24356:SF190
organism: Macaca mulatta

uniprot P53349 759
type: UnificationXref
id: P53349
db: uniprot

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit
type: ProteinReference
xref: PTHR10048:SF107
xref: uniprot F6VXG1 892
organism: Xenopus tropicalis

14-3-3 protein, putative
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q5K8Z6 244
organism: Cryptococcus neoformans

Protein kinase C eta type
type: ProteinReference
xref: uniprot H2Q8F2 1149
xref: PTHR24356:SF192
organism: Pan troglodytes

uniprot Q15173 540
type: UnificationXref
id: Q15173
db: uniprot

PI3K
type: Protein
entity reference: PI3K
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

HETERODIMER_ASSOCIATION_LEFT__FRS2-_PI3K-_PLCgamma-_RasGAP-_FGFR1_4-_SHP2-_Complex__SOS_Grb2_-_SHC-RIGHT__Complex__FGFR1_4_PLC_gamma__RasGAP_PI3K__FRS2_SHP2__SHC_Grb2__SOS_-_r34
type: ComplexAssembly
spontaneous: true
conversion direction: LEFT_TO_RIGHT
xref: HETERODIMER ASSOCIATION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1230
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1236
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1234
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1233
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1231
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1232
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1235
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1228
participant stoichiometry: PARTICIPANT STOICHIOMETRY r34 1229
left: SHC
left: FRS2
left: FGFR1-4
left: PLCgamma
left: Complex (SOS/Grb2)
left: SHP2
left: PI3K
left: RasGAP
interaction type: HETERODIMER_ASSOCIATION
right: Complex (FGFR1-4/PLC_gamma/ RasGAP/PI3K/ FRS2/SHP2/ SHC/Grb2/ SOS)

MKK3,6 s52 a65 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot F1Q4F8 666
type: UnificationXref
id: F1Q4F8
db: uniprot

PTHR24416:SF505
type: RelationshipXref
id: PTHR24416:SF505
db: PANTHER Family
relationship type: By Homology

uniprot Q02956 1180
type: UnificationXref
id: Q02956
db: uniprot

uniprot P48554 1061
type: UnificationXref
id: P48554
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7D0A6 829
organism: Monodelphis domestica

Serine/threonine-protein phosphatase
type: ProteinReference
xref: PTHR45619:SF44
xref: uniprot Q803G3 582
organism: Danio rerio

uniprot Q9VD01 640
type: UnificationXref
id: Q9VD01
db: uniprot

AGAP000310-PA
type: ProteinReference
xref: uniprot Q7PRZ7 285
organism: Anopheles gambiae

uniprot H2RIH8 1118
type: UnificationXref
id: H2RIH8
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot H2QT14 483
xref: PTHR10257:SF89
organism: Pan troglodytes

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 234

Akt s22 a25 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.141592653589793

14-3-3 protein beta/alpha
type: ProteinReference
xref: PTHR18860:SF28
xref: uniprot Q5ZLQ6 251
organism: Gallus gallus

uniprot E2RL20 990
type: UnificationXref
id: E2RL20
db: uniprot

uniprot P63086 340
type: UnificationXref
id: P63086
db: uniprot

uniprot F7BYT3 618
type: UnificationXref
id: F7BYT3
db: uniprot

uniprot E1BE66 882
type: UnificationXref
id: E1BE66
db: uniprot

P00630
type: UnificationXref
id: P00630
db: PANTHER Pathway Component

GTPase NRas
type: ProteinReference
xref: PTHR24070:SF189
xref: uniprot P01111 706
organism: Homo sapiens

GTPase HRas
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot P01112 707
organism: Homo sapiens

14-3-3 protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot A7Z057 140
organism: Bos taurus

Protein kinase C delta type
type: ProteinReference
xref: PTHR24356:SF365
xref: uniprot P28867 1168
organism: Mus musculus

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot F6Z879 828
organism: Monodelphis domestica

uniprot P62260 219
type: UnificationXref
id: P62260
db: uniprot

uniprot Q9WTU6 390
type: UnificationXref
id: Q9WTU6
db: uniprot

uniprot A4FV68 411
type: UnificationXref
id: A4FV68
db: uniprot

uniprot P31947 199
type: UnificationXref
id: P31947
db: uniprot

Serine/threonine-protein phosphatase 2A catalytic subunit A
type: ProteinReference
xref: uniprot Q9XZE5 607
xref: PTHR45619:SF12
organism: Dictyostelium discoideum

uniprot Q9U9A3 601
type: UnificationXref
id: Q9U9A3
db: uniprot

uniprot Q7TNP2 579
type: UnificationXref
id: Q7TNP2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G6M6 297
organism: Macaca mulatta

P00628
type: UnificationXref
id: P00628
db: PANTHER Pathway Component

PTHR24070:SF388
type: RelationshipXref
id: PTHR24070:SF388
db: PANTHER Family
relationship type: By Homology

P00629
type: UnificationXref
id: P00629
db: PANTHER Pathway Component

PTHR24070:SF385
type: RelationshipXref
id: PTHR24070:SF385
db: PANTHER Family
relationship type: By Homology

uniprot Q9W6A1 134
type: UnificationXref
id: Q9W6A1
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF162
xref: uniprot A0A2I3RZ31 363
organism: Pan troglodytes

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
type: ProteinReference
xref: PTHR10257:SF19
xref: uniprot Q13362 537
organism: Homo sapiens

Protein kinase C
type: ProteinReference
xref: PTHR24356:SF158
xref: uniprot F7A632 1143
organism: Monodelphis domestica

uniprot H2QRH7 482
type: UnificationXref
id: H2QRH7
db: uniprot

GH14779p
type: ProteinReference
xref: uniprot Q9VD02 641
organism: Drosophila melanogaster

P00623
type: UnificationXref
id: P00623
db: PANTHER Pathway Component

LP12095p
type: ProteinReference
xref: uniprot Q9VD01 640
organism: Drosophila melanogaster

Mitogen-activated protein kinase kinase kinase nsy-1
type: ProteinReference
xref: uniprot Q21029 760
organism: Caenorhabditis elegans

P00626
type: UnificationXref
id: P00626
db: PANTHER Pathway Component

P00627
type: UnificationXref
id: P00627
db: PANTHER Pathway Component

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF15
xref: uniprot A0A1D5QAU9 823
organism: Macaca mulatta

P00624
type: UnificationXref
id: P00624
db: PANTHER Pathway Component

P00625
type: UnificationXref
id: P00625
db: PANTHER Pathway Component

uniprot A0A3Q2TY19 365
type: UnificationXref
id: A0A3Q2TY19
db: uniprot

uniprot A9TXC9 425
type: UnificationXref
id: A9TXC9
db: uniprot

uniprot Q5ZLQ6 251
type: UnificationXref
id: Q5ZLQ6
db: uniprot

P00641
type: UnificationXref
id: P00641
db: PANTHER Pathway Component

uniprot A0A1D5R8E9 839
type: UnificationXref
id: A0A1D5R8E9
db: uniprot

P00640
type: UnificationXref
id: P00640
db: PANTHER Pathway Component

PTHR24070:SF380
type: RelationshipXref
id: PTHR24070:SF380
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase 8
type: ProteinReference
xref: uniprot Q91Y86 388
organism: Mus musculus

P00639
type: UnificationXref
id: P00639
db: PANTHER Pathway Component

Dual specificity mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot P52564 282
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF1
xref: uniprot A0A1D5PWQ5 395
organism: Gallus gallus

uniprot A0A2I3RZ31 363
type: UnificationXref
id: A0A2I3RZ31
db: uniprot

Mitogen-activated protein kinase 13
type: ProteinReference
xref: uniprot Q9WTY9 1033
xref: PTHR24055:SF107
organism: Rattus norvegicus

Fibroblast growth factor
type: ProteinReference
xref: uniprot H2Q4B5 56
organism: Pan troglodytes

P00631
type: UnificationXref
id: P00631
db: PANTHER Pathway Component

Fibroblast growth factor
type: ProteinReference
xref: uniprot H2Q4B4 55
xref: PTHR11486:SF31
organism: Pan troglodytes

P00632
type: UnificationXref
id: P00632
db: PANTHER Pathway Component

P00633
type: UnificationXref
id: P00633
db: PANTHER Pathway Component

P00634
type: UnificationXref
id: P00634
db: PANTHER Pathway Component

PTHR10257:SF80
type: RelationshipXref
id: PTHR10257:SF80
db: PANTHER Family
relationship type: By Homology

P00635
type: UnificationXref
id: P00635
db: PANTHER Pathway Component

uniprot A0A3Q1MM63 407
type: UnificationXref
id: A0A3Q1MM63
db: uniprot

P00636
type: UnificationXref
id: P00636
db: PANTHER Pathway Component

uniprot F6RWC6 36
type: UnificationXref
id: F6RWC6
db: uniprot

PARTICIPANT STOICHIOMETRY r18 1252
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 1.0

P00637
type: UnificationXref
id: P00637
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r18 1253
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 2.0

uniprot P29350 1121
type: UnificationXref
id: P29350
db: uniprot

PTHR24072:SF333
type: RelationshipXref
id: PTHR24072:SF333
db: PANTHER Family
relationship type: By Homology

SOS Ras/Rac guanine nucleotide exchange factor 1
type: ProteinReference
xref: uniprot H2R8U9 947
xref: PTHR23113:SF168
organism: Pan troglodytes

P00638
type: UnificationXref
id: P00638
db: PANTHER Pathway Component

uniprot O43609 303
type: UnificationXref
id: O43609
db: uniprot

uniprot O00329 907
type: UnificationXref
id: O00329
db: uniprot

FGFR1-4
type: Protein
entity reference: FGFR1-4
feature: FGFR1 4 s76 a4 rs2
feature: FGFR1 4 s76 a4 rs1
feature: FGFR1 4 s76 a4 rs3
feature: FGFR1 4 s76 a4 rs4
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

PARTICIPANT STOICHIOMETRY r30 1246
type: Stoichiometry
physical entity: MEKK1-5
stoichiometric coefficient: 1.0

uniprot P62716 516
type: UnificationXref
id: P62716
db: uniprot

uniprot F6TNW3 167
type: UnificationXref
id: F6TNW3
db: uniprot

PTHR10257:SF89
type: RelationshipXref
id: PTHR10257:SF89
db: PANTHER Family
relationship type: By Homology

PARTICIPANT STOICHIOMETRY r30 1247
type: Stoichiometry
physical entity: MEKK1-5
stoichiometric coefficient: 1.0

Mitogen-activated protein kinase kinase 6
type: ProteinReference
xref: uniprot F7AGV5 276
organism: Monodelphis domestica

Trichoplax adhaerens
type: BioSource
xref: ncbitaxon 10228 428

uniprot P41499 1124
type: UnificationXref
id: P41499
db: uniprot

PTHR24055:SF109
type: RelationshipXref
id: PTHR24055:SF109
db: PANTHER Family
relationship type: By Homology

uniprot O35099 757
type: UnificationXref
id: O35099
db: uniprot

PTHR24055:SF107
type: RelationshipXref
id: PTHR24055:SF107
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor receptor 4
type: ProteinReference
xref: PTHR24416:SF343
xref: uniprot P22455 811
organism: Homo sapiens

Uncharacterized protein
type: ProteinReference
xref: uniprot F7F6D5 778
xref: PTHR21258:SF40
organism: Monodelphis domestica

PTHR12365:SF6
type: RelationshipXref
id: PTHR12365:SF6
db: PANTHER Family
relationship type: By Homology

PTHR12365:SF7
type: RelationshipXref
id: PTHR12365:SF7
db: PANTHER Family
relationship type: By Homology

uniprot P56932 513
type: UnificationXref
id: P56932
db: uniprot

PTHR24072:SF325
type: RelationshipXref
id: PTHR24072:SF325
db: PANTHER Family
relationship type: By Homology

Uncharacterized protein
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot F7H9J1 748
organism: Macaca mulatta

AGAP008909-PA
type: ProteinReference
xref: uniprot Q7PWN1 630
organism: Anopheles gambiae

PTHR12365:SF8
type: RelationshipXref
id: PTHR12365:SF8
db: PANTHER Family
relationship type: By Homology

P00648
type: UnificationXref
id: P00648
db: PANTHER Pathway Component

P00646
type: UnificationXref
id: P00646
db: PANTHER Pathway Component

P00647
type: UnificationXref
id: P00647
db: PANTHER Pathway Component

P00644
type: UnificationXref
id: P00644
db: PANTHER Pathway Component

uniprot P54676 925
type: UnificationXref
id: P54676
db: uniprot

PTHR10257:SF92
type: RelationshipXref
id: PTHR10257:SF92
db: PANTHER Family
relationship type: By Homology

P00645
type: UnificationXref
id: P00645
db: PANTHER Pathway Component

P00642
type: UnificationXref
id: P00642
db: PANTHER Pathway Component

DShc protein
type: ProteinReference
xref: PTHR10337:SF11
xref: uniprot Q9V3C8 868
organism: Drosophila melanogaster

P00643
type: UnificationXref
id: P00643
db: PANTHER Pathway Component

SOS
type: Protein
entity reference: SOS
feature: COMPLEX PARTICIPANT BINDING FEATURE s37 sa15 1201
feature: ACTIVE 287
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q90687 1126
type: UnificationXref
id: Q90687
db: uniprot

uniprot P79737 722
type: UnificationXref
id: P79737
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF3
xref: uniprot Q4R0X9 116
organism: Gallus gallus

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot E2R186 793
xref: PTHR24416:SF131
organism: Canis lupus familiaris

uniprot A0A1D5QKD3 959
type: UnificationXref
id: A0A1D5QKD3
db: uniprot

uniprot F7DLW2 469
type: UnificationXref
id: F7DLW2
db: uniprot

uniprot Q4QGB0 976
type: UnificationXref
id: Q4QGB0
db: uniprot

Serine/threonine-protein phosphatase 4 catalytic subunit
type: ProteinReference
xref: uniprot P32345 501
organism: Saccharomyces cerevisiae

uniprot H2R0G7 378
type: UnificationXref
id: H2R0G7
db: uniprot

Rac family small GTPase 2
type: ProteinReference
xref: uniprot Q5U1Y2 1074
xref: PTHR24072:SF169
organism: Rattus norvegicus

Akt
type: ProteinReference
xref: P00632
standard name: protein kinase B
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.Akt
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Thymoma viral proto-oncogene Synonym: PKB,RAC protein kinase,protein kinase B Accession: P00632
member entity reference: RAC-beta serine/threonine-protein kinase
member entity reference: Non-specific serine/threonine protein kinase
member entity reference: RAC-gamma serine/threonine-protein kinase
member entity reference: RAC-alpha serine/threonine-protein kinase
member entity reference: RAC serine/threonine-protein kinase
member entity reference: Serine/threonine-protein kinase akt-1

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C4M5Q7 1040
organism: Entamoeba histolytica

uniprot Q28J96 815
type: UnificationXref
id: Q28J96
db: uniprot

uniprot Q64617 1189
type: UnificationXref
id: Q64617
db: uniprot

14-3-3 protein epsilon
type: ProteinReference
xref: uniprot Q7PX08 260
xref: PTHR18860:SF17
organism: Anopheles gambiae

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__p38-RIGHT__p38-_r26
controller: MKK3,6

PTHR24072:SF315
type: RelationshipXref
id: PTHR24072:SF315
db: PANTHER Family
relationship type: By Homology

SHC-transforming protein 1
type: ProteinReference
xref: uniprot Q0IIE2 863
xref: PTHR10337:SF2
organism: Bos taurus

Sprouty RTK-signaling antagonist 2
type: ProteinReference
xref: PTHR12365:SF8
xref: uniprot Q5Y173 307
organism: Xenopus tropicalis

PTHR24072:SF310
type: RelationshipXref
id: PTHR24072:SF310
db: PANTHER Family
relationship type: By Homology

uniprot Q13588 652
type: UnificationXref
id: Q13588
db: uniprot

uniprot P24583 1166
type: UnificationXref
id: P24583
db: uniprot

uniprot P42338 918
type: UnificationXref
id: P42338
db: uniprot

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 207

uniprot Q10R90 535
type: UnificationXref
id: Q10R90
db: uniprot

Ashbya gossypii
type: BioSource
xref: ncbitaxon 284811 259

ncbitaxon 9913 15
type: UnificationXref
id: 9913
db: ncbitaxon

14-3-3 zeta
type: ProteinReference
xref: uniprot A8XQR9 145
xref: PTHR18860:SF106
organism: Caenorhabditis briggsae

uniprot F1Q3J6 1114
type: UnificationXref
id: F1Q3J6
db: uniprot

Sprouty RTK signaling antagonist 3
type: ProteinReference
xref: uniprot F1MIH6 294
organism: Bos taurus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
type: ProteinReference
xref: uniprot Q60996 559
xref: PTHR10257:SF19
organism: Mus musculus

Protein phosphatase PP2A regulatory subunit A
type: ProteinReference
xref: uniprot P31383 500
organism: Saccharomyces cerevisiae

uniprot Q6LC82 1080
type: UnificationXref
id: Q6LC82
db: uniprot

uniprot Q6GL60 1079
type: UnificationXref
id: Q6GL60
db: uniprot

uniprot P30153 498
type: UnificationXref
id: P30153
db: uniprot

GH14494p
type: ProteinReference
xref: uniprot Q9VI09 643
organism: Drosophila melanogaster

GH28351p
type: ProteinReference
xref: uniprot Q9VI08 642
organism: Drosophila melanogaster

GH13542p
type: ProteinReference
xref: uniprot Q8IR23 1108
xref: PTHR10194:SF19
organism: Drosophila melanogaster

ncbitaxon 321614 324
type: UnificationXref
id: 321614
db: ncbitaxon

ncbitaxon 9615 22
type: UnificationXref
id: 9615
db: ncbitaxon

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A7RFC7 415
organism: Nematostella vectensis

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F1PV54 451
xref: PTHR10257:SF4
organism: Canis lupus familiaris

uniprot W4ZAK5 612
type: UnificationXref
id: W4ZAK5
db: uniprot

HRAS isoform 2
type: ProteinReference
xref: PTHR24070:SF385
xref: uniprot K7ALD7 705
organism: Pan troglodytes

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot O02812 1014
xref: PTHR24055:SF110
organism: Canis lupus familiaris

uniprot F5HM75 616
type: UnificationXref
id: F5HM75
db: uniprot

uniprot P31383 500
type: UnificationXref
id: P31383
db: uniprot

RAS p21 protein activator 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot F7EPN2 1099
organism: Ornithorhynchus anatinus

Protein kinase C-like
type: ProteinReference
xref: uniprot P87253 1177
xref: PTHR24356:SF390
organism: Neurospora crassa

uniprot Q04759 1181
type: UnificationXref
id: Q04759
db: uniprot

uniprot P50520 921
type: UnificationXref
id: P50520
db: uniprot

uniprot P63102 222
type: UnificationXref
id: P63102
db: uniprot

uniprot P01112 707
type: UnificationXref
id: P01112
db: uniprot

uniprot Q13362 537
type: UnificationXref
id: Q13362
db: uniprot

uniprot A2VDZ0 409
type: UnificationXref
id: A2VDZ0
db: uniprot

Serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' epsilon isoform
type: ProteinReference
xref: uniprot Q9SV41 599
organism: Arabidopsis thaliana

uniprot Q9Y0B7 608
type: UnificationXref
id: Q9Y0B7
db: uniprot

uniprot F6RAU4 34
type: UnificationXref
id: F6RAU4
db: uniprot

uniprot P79150 114
type: UnificationXref
id: P79150
db: uniprot

STATE_TRANSITION_LEFT__RKIP-RIGHT__RKIP-_r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 1266
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 1267
left: RKIP
interaction type: STATE_TRANSITION
right: RKIP

Protein CBR-MIG-2
type: ProteinReference
xref: uniprot A8XQS8 1036
organism: Caenorhabditis briggsae

Uncharacterized protein rasC
type: ProteinReference
xref: uniprot F1A411 698
xref: PTHR24070:SF251
organism: Dictyostelium purpureum

Cell division control protein 42 homolog
type: ProteinReference
xref: uniprot P0CY33 1052
organism: Candida albicans

PTHR24055:SF110
type: RelationshipXref
id: PTHR24055:SF110
db: PANTHER Family
relationship type: By Homology

Fibroblast growth factor
type: ProteinReference
xref: PTHR11486:SF4
xref: uniprot F2Z4J0 27
organism: Bos taurus

Mitogen-activated protein kinase 9
type: ProteinReference
xref: uniprot Q9WTU6 390
organism: Mus musculus

uniprot A8JGV6 141
type: UnificationXref
id: A8JGV6
db: uniprot

JNK1 3 s40 a42 rs2
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot F7G755 474
xref: PTHR10257:SF92
organism: Ornithorhynchus anatinus

uniprot Q5M824 864
type: UnificationXref
id: Q5M824
db: uniprot

Fibroblast growth factor 11
type: ProteinReference
xref: uniprot A0A2J8KPL7 12
organism: Pan troglodytes

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot F7HSM1 477
xref: PTHR45619:SF44
organism: Macaca mulatta

uniprot Q9WUA6 685
type: UnificationXref
id: Q9WUA6
db: uniprot

Rop-family small GTPase
type: ProteinReference
xref: uniprot A9TLC7 1038
organism: Physcomitrella patens

uniprot A0A0G2JZZ5 770
type: UnificationXref
id: A0A0G2JZZ5
db: uniprot

uniprot F7GY91 1049
type: UnificationXref
id: F7GY91
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot Q08DP7 527
xref: PTHR10257:SF4
organism: Bos taurus

uniprot P04049 993
type: UnificationXref
id: P04049
db: uniprot

uniprot A0A1D5QAU9 823
type: UnificationXref
id: A0A1D5QAU9
db: uniprot

uniprot Q5E9X2 284
type: UnificationXref
id: Q5E9X2
db: uniprot

Mitogen-activated protein kinase kinase kinase 6
type: ProteinReference
xref: uniprot Q9WTR2 767
organism: Mus musculus

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot Q380Z0 545
organism: Trypanosoma brucei

Strongylocentrotus purpuratus
type: BioSource
xref: ncbitaxon 7668 613

Mitogen-activated protein kinase 13
type: ProteinReference
xref: PTHR24055:SF107
xref: uniprot Q9N272 1032
organism: Pan troglodytes

Protein CENTRORADIALIS-like
type: ProteinReference
xref: uniprot Q9ZNV5 646
organism: Arabidopsis thaliana

PTHR24055:SF146
type: RelationshipXref
id: PTHR24055:SF146
db: PANTHER Family
relationship type: By Homology

Mitogen-activated protein kinase kinase kinase 1
type: ProteinReference
xref: PTHR24361:SF414
xref: uniprot H2R5K3 753
organism: Pan troglodytes

uniprot P63330 518
type: UnificationXref
id: P63330
db: uniprot

uniprot A0A1D5RL09 400
type: UnificationXref
id: A0A1D5RL09
db: uniprot

Mitogen-activated protein kinase 1
type: ProteinReference
xref: uniprot Q84UI5 355
organism: Oryza sativa

JNK1 3 s40 a42 rs1
type: ModificationFeature
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

uniprot A0A3Q2U4X3 661
type: UnificationXref
id: A0A3Q2U4X3
db: uniprot

Ras-like protein 2
type: ProteinReference
xref: uniprot P01120 709
xref: PTHR24070:SF17
organism: Saccharomyces cerevisiae

Serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' zeta isoform
type: ProteinReference
xref: uniprot Q9LVE2 597
organism: Arabidopsis thaliana

PTHR11362:SF82
type: RelationshipXref
id: PTHR11362:SF82
db: PANTHER Family
relationship type: By Homology

PTHR10336:SF173
type: RelationshipXref
id: PTHR10336:SF173
db: PANTHER Family
relationship type: By Homology

Raf-1
type: Protein
entity reference: Raf-1
feature: Raf 1 s24 a27 rs2
feature: Raf 1 s24 a27 rs1
feature: ACTIVE 287
feature: Raf 1 s24 a27 rs4
feature: Raf 1 s24 a27 rs3
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Fibroblast growth factor receptor substrate 2
type: ProteinReference
xref: uniprot E1B7I9 774
xref: PTHR21258:SF40
organism: Bos taurus

Fibroblast growth factor 9
type: ProteinReference
xref: uniprot P31371 91
organism: Homo sapiens

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot F6TXC2 1009
xref: PTHR24055:SF107
organism: Monodelphis domestica

uniprot Q14738 538
type: UnificationXref
id: Q14738
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot V5IKE7 360
xref: PTHR24055:SF158
organism: Neurospora crassa

Fibroblast growth factor receptor
type: ProteinReference
xref: uniprot F7FZS3 802
xref: PTHR24416:SF505
organism: Macaca mulatta

Ras-like protein 1
type: ProteinReference
xref: uniprot P01119 708
xref: PTHR24070:SF17
organism: Saccharomyces cerevisiae

uniprot B7QHS1 430
type: UnificationXref
id: B7QHS1
db: uniprot

uniprot Q9LHE7 595
type: UnificationXref
id: Q9LHE7
db: uniprot

uniprot Q9IAI5 132
type: UnificationXref
id: Q9IAI5
db: uniprot

uniprot A7T2Q5 417
type: UnificationXref
id: A7T2Q5
db: uniprot

uniprot P63318 1174
type: UnificationXref
id: P63318
db: uniprot

uniprot F6X0X1 460
type: UnificationXref
id: F6X0X1
db: uniprot

Ras
type: ProteinReference
xref: P00633
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.Ras
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: Ras Synonym: Synonym not specified Accession: P00633
member entity reference: V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
member entity reference: GTPase NRas
member entity reference: GTPase HRas
member entity reference: Ras-like protein 1
member entity reference: NRAS isoform 1
member entity reference: Ras-like protein rasS
member entity reference: Uncharacterized protein rasS
member entity reference: Uncharacterized protein rasG
member entity reference: AGAP002219-PA
member entity reference: Ras-like protein 2
member entity reference: GTPase KRas
member entity reference: Ras-like protein rasG
member entity reference: Uncharacterized protein
member entity reference: -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
member entity reference: Harvey rat sarcoma viral oncogene homolog
member entity reference: Uncharacterized protein rasD
member entity reference: Ras-like protein rasB
member entity reference: Ras-like protein
member entity reference: Ras protein let-60
member entity reference: NRAS protein
member entity reference: Protein CBR-LET-60
member entity reference: Predicted protein
member entity reference: HRas proto-oncogene, GTPase a
member entity reference: Ras-like protein rasD
member entity reference: GTPase HRas isoform 1
member entity reference: HRAS isoform 2
member entity reference: Uncharacterized protein rasB
member entity reference: Uncharacterized protein rasC
member entity reference: Protein ras-1
member entity reference: Ras-like protein rasC
member entity reference: NRAS proto-oncogene, GTPase

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot Q7ZW20 264
organism: Danio rerio

uniprot Q5ZKC9 249
type: UnificationXref
id: Q5ZKC9
db: uniprot

uniprot P16092 805
type: UnificationXref
id: P16092
db: uniprot

uniprot Q95ME4 731
type: UnificationXref
id: Q95ME4
db: uniprot

Protein phosphatase 2 regulatory subunit A, beta
type: ProteinReference
xref: uniprot F7C2I9 466
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: PTHR48013:SF8
xref: uniprot F6S9S9 963
organism: Monodelphis domestica

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot C4M5Z7 1042
organism: Entamoeba histolytica

PARTICIPANT STOICHIOMETRY r25 1277
type: Stoichiometry
physical entity: MKK3,6
stoichiometric coefficient: 1.0

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF1
xref: uniprot A0A2I3SQA4 402
organism: Pan troglodytes

PARTICIPANT STOICHIOMETRY r25 1276
type: Stoichiometry
physical entity: MKK3,6
stoichiometric coefficient: 1.0

uniprot F7DVL1 1146
type: UnificationXref
id: F7DVL1
db: uniprot

PTHR24055:SF162
type: RelationshipXref
id: PTHR24055:SF162
db: PANTHER Family
relationship type: By Homology

uniprot Q19266 1185
type: UnificationXref
id: Q19266
db: uniprot

uniprot P18460 806
type: UnificationXref
id: P18460
db: uniprot

FRS3 isoform 1
type: ProteinReference
xref: uniprot H2QSZ7 779
organism: Pan troglodytes

uniprot I0FMS6 1119
type: UnificationXref
id: I0FMS6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A3Q1LTT9 1004
xref: PTHR24055:SF110
organism: Bos taurus

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5QUZ8 315
xref: PTHR24055:SF203
organism: Macaca mulatta

uniprot P21781 90
type: UnificationXref
id: P21781
db: uniprot

uniprot F6X958 462
type: UnificationXref
id: F6X958
db: uniprot

uniprot Q39023 344
type: UnificationXref
id: Q39023
db: uniprot

Mitogen-activated protein kinase kinase kinase 3
type: ProteinReference
xref: PTHR24361:SF656
xref: uniprot Q61084 762
organism: Mus musculus

MEK1 2 s26 a29 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

Mitogen-activated protein kinase kinase kinase 2
type: ProteinReference
xref: uniprot Q61083 761
xref: PTHR24361:SF342
organism: Mus musculus

14-3-3 protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot P61981 214
organism: Homo sapiens

14-3-3 protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot P61982 215
organism: Mus musculus

uniprot P36364 93
type: UnificationXref
id: P36364
db: uniprot

PTHR24055:SF158
type: RelationshipXref
id: PTHR24055:SF158
db: PANTHER Family
relationship type: By Homology

14-3-3 protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot P61983 216
organism: Rattus norvegicus

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: uniprot K7CXU1 485
xref: PTHR10257:SF6
organism: Pan troglodytes

Serine/threonine-protein phosphatase PP-X isozyme 2
type: ProteinReference
xref: uniprot P48528 510
organism: Arabidopsis thaliana

Serine/threonine-protein phosphatase PP-X isozyme 1
type: ProteinReference
xref: uniprot P48529 511
organism: Arabidopsis thaliana

Protein kinase C theta type
type: ProteinReference
xref: uniprot Q9WTQ0 1193
xref: PTHR24356:SF181
organism: Rattus norvegicus

PTHR24055:SF154
type: RelationshipXref
id: PTHR24055:SF154
db: PANTHER Family
relationship type: By Homology

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
type: ProteinReference
xref: uniprot P16885 850
xref: PTHR10336:SF25
organism: Homo sapiens

uniprot H2QDN0 751
type: UnificationXref
id: H2QDN0
db: uniprot

uniprot P49187 382
type: UnificationXref
id: P49187
db: uniprot

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
type: ProteinReference
xref: PTHR11871:SF1
xref: uniprot Q0D2F4 528
organism: Xenopus tropicalis

uniprot F7EH19 326
type: UnificationXref
id: F7EH19
db: uniprot

Dictyostelium discoideum
type: BioSource
xref: ncbitaxon 44689 213

Serine/threonine-protein phosphatase
type: ProteinReference
xref: uniprot A9SKN8 424
organism: Physcomitrella patens

uniprot F7F3Q5 473
type: UnificationXref
id: F7F3Q5
db: uniprot

uniprot Q7ZUQ2 581
type: UnificationXref
id: Q7ZUQ2
db: uniprot

Tyrosine-protein phosphatase non-receptor type 6
type: ProteinReference
xref: uniprot P81718 1125
xref: PTHR46257:SF4
organism: Rattus norvegicus

RAS p21 protein activator 2
type: ProteinReference
xref: PTHR10194:SF21
xref: uniprot E2QUM7 1094
organism: Canis lupus familiaris

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: PTHR11871:SF5
xref: uniprot A0A1D5R6Y2 399
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r17 1255
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 2.0

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 546

Ras-related C3 botulinum toxin substrate 2
type: ProteinReference
xref: PTHR24072:SF169
xref: uniprot Q05144 1067
organism: Mus musculus

uniprot Q9DGE2 1031
type: UnificationXref
id: Q9DGE2
db: uniprot

Protein sprouty homolog 4
type: ProteinReference
xref: PTHR12365:SF6
xref: uniprot Q9WTP2 312
organism: Mus musculus

PARTICIPANT STOICHIOMETRY r17 1254
type: Stoichiometry
physical entity: FGFR1-4
stoichiometric coefficient: 1.0

Fibroblast growth factor 1
type: ProteinReference
xref: PTHR11486:SF86
xref: uniprot P05230 78
organism: Homo sapiens

uniprot A8WWS6 419
type: UnificationXref
id: A8WWS6
db: uniprot

uniprot V5IKE7 360
type: UnificationXref
id: V5IKE7
db: uniprot

uniprot Q54QR9 553
type: UnificationXref
id: Q54QR9
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot F6QPE1 32
xref: PTHR11486:SF17
organism: Xenopus tropicalis

uniprot P29310 194
type: UnificationXref
id: P29310
db: uniprot

uniprot F2Z4J0 27
type: UnificationXref
id: F2Z4J0
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot Q8VI79 121
organism: Rattus norvegicus

uniprot Q08012 651
type: UnificationXref
id: Q08012
db: uniprot

Nematostella vectensis
type: BioSource
xref: ncbitaxon 45351 416

uniprot Q8R5L5 119
type: UnificationXref
id: Q8R5L5
db: uniprot

uniprot Q9S7R5 638
type: UnificationXref
id: Q9S7R5
db: uniprot

SOS
type: Protein
entity reference: SOS
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

Uncharacterized protein
type: ProteinReference
xref: uniprot F7BD74 277
xref: PTHR48013:SF21
organism: Monodelphis domestica

GRB2-related adapter protein
type: ProteinReference
xref: uniprot A6QLK6 647
xref: PTHR46037:SF2
organism: Bos taurus

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot A0A1D5QLW6 838
xref: PTHR10336:SF25
organism: Macaca mulatta

MKK4,7 s48 a62 rs2
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=6.28

uniprot H2RA86 330
type: UnificationXref
id: H2RA86
db: uniprot

uniprot A8WRD7 1005
type: UnificationXref
id: A8WRD7
db: uniprot

uniprot F7F6D5 778
type: UnificationXref
id: F7F6D5
db: uniprot

uniprot Q9XW37 645
type: UnificationXref
id: Q9XW37
db: uniprot

uniprot P09215 1159
type: UnificationXref
id: P09215
db: uniprot

uniprot A6H792 772
type: UnificationXref
id: A6H792
db: uniprot

Protein phosphatase 2A scaffold subunit
type: ProteinReference
xref: uniprot Q54QR9 553
organism: Dictyostelium discoideum

uniprot Q9VD02 641
type: UnificationXref
id: Q9VD02
db: uniprot

uniprot P50904 1105
type: UnificationXref
id: P50904
db: uniprot

Protein kinase C zeta type
type: ProteinReference
xref: PTHR24356:SF170
xref: uniprot Q05513 1182
organism: Homo sapiens

uniprot Q39247 550
type: UnificationXref
id: Q39247
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: PTHR24055:SF203
xref: uniprot H2QLB4 329
organism: Pan troglodytes

14-3-3-like protein GF14-D
type: ProteinReference
xref: uniprot Q2R2W2 237
xref: PTHR18860:SF69
organism: Oryza sativa

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit
type: ProteinReference
xref: PTHR10257:SF89
xref: uniprot A0A1D5RL09 400
organism: Macaca mulatta

uniprot P54673 922
type: UnificationXref
id: P54673
db: uniprot

uniprot Q7QCN5 1107
type: UnificationXref
id: Q7QCN5
db: uniprot

AGAP012252-PA (Fragment)
type: ProteinReference
xref: uniprot Q7Q042 1190
xref: PTHR24356:SF390
organism: Anopheles gambiae

uniprot Q04970 723
type: UnificationXref
id: Q04970
db: uniprot

uniprot Q7PD38 573
type: UnificationXref
id: Q7PD38
db: uniprot

uniprot Q9ASJ1 635
type: UnificationXref
id: Q9ASJ1
db: uniprot

uniprot P70492 113
type: UnificationXref
id: P70492
db: uniprot

MEK1 2 s26 a29 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

MKK4,7 s48 a62 rs1
type: ModificationFeature
modification type: phosphorylated residue
comment: MODIFICATION_RESIDUE_SIDE=none
comment: MODIFICATION_RESIDUE_TYPE=residue
comment: MODIFICATION_RESIDUE_NAME=
comment: MODIFICATION_RESIDUE_ANGLE=3.14

PTHR10257:SF19
type: RelationshipXref
id: PTHR10257:SF19
db: PANTHER Family
relationship type: By Homology

uniprot Q642H5 561
type: UnificationXref
id: Q642H5
db: uniprot

uniprot I0FRT6 754
type: UnificationXref
id: I0FRT6
db: uniprot

Mitogen-activated protein kinase
type: ProteinReference
xref: uniprot A0A1D5Q5Z6 314
xref: PTHR24055:SF393
organism: Macaca mulatta

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
type: ProteinReference
xref: PTHR18860:SF22
xref: uniprot Q0V9W8 235
organism: Xenopus tropicalis

Fibroblast growth factor receptor
type: ProteinReference
xref: PTHR24416:SF505
xref: uniprot A0A0G2K210 785
organism: Rattus norvegicus

Protein kinase C alpha type
type: ProteinReference
xref: uniprot P17252 1163
xref: PTHR24356:SF193
organism: Homo sapiens

uniprot E2RGU7 1136
type: UnificationXref
id: E2RGU7
db: uniprot

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
type: ProteinReference
xref: uniprot Q9VXH3 855
organism: Drosophila melanogaster

uniprot P48463 509
type: UnificationXref
id: P48463
db: uniprot

Rac-like GTP-binding protein ARAC11
type: ProteinReference
xref: PTHR24072:SF333
xref: uniprot P92978 1065
organism: Arabidopsis thaliana

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
type: ProteinReference
xref: uniprot A0A2R8Q610 406
xref: PTHR11871:SF1
organism: Danio rerio

STATE_TRANSITION
type: InteractionVocabulary

uniprot P36872 505
type: UnificationXref
id: P36872
db: uniprot

Serine/threonine-protein phosphatase PP2A catalytic subunit
type: ProteinReference
xref: uniprot P48580 512
organism: Neurospora crassa

uniprot Q8BTI9 932
type: UnificationXref
id: Q8BTI9
db: uniprot

uniprot F6RCU6 670
type: UnificationXref
id: F6RCU6
db: uniprot

uniprot P92177 231
type: UnificationXref
id: P92177
db: uniprot

uniprot A7STP5 690
type: UnificationXref
id: A7STP5
db: uniprot

Mitogen-activated protein kinase 14
type: ProteinReference
xref: uniprot Q16539 1024
xref: PTHR24055:SF110
organism: Homo sapiens

uniprot A8X1S0 367
type: UnificationXref
id: A8X1S0
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
type: ProteinReference
xref: uniprot Q16537 541
xref: PTHR10257:SF80
organism: Homo sapiens

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
type: ProteinReference
xref: uniprot Q7TNP2 579
organism: Mus musculus

Fibroblast growth factor
type: ProteinReference
xref: uniprot Q9IAI5 132
organism: Gallus gallus

Fibroblast growth factor
type: ProteinReference
xref: uniprot E1BHC1 19
organism: Bos taurus

uniprot P54185 624
type: UnificationXref
id: P54185
db: uniprot

uniprot F1M7Y5 1138
type: UnificationXref
id: F1M7Y5
db: uniprot

RAS p21 protein activator 1
type: ProteinReference
xref: PTHR10194:SF19
xref: uniprot E9PYG6 1095
organism: Mus musculus

Grb2 s41 sa16 STOICHIOMETRY ID COMPLEX
type: Stoichiometry
physical entity: Grb2
stoichiometric coefficient: 1.0

uniprot H2PYF3 750
type: UnificationXref
id: H2PYF3
db: uniprot

FGF
type: ProteinReference
xref: P00623
standard name: fibroblast growth factor
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: fibroblast growth factor Synonym: Synonym not specified Accession: P00623
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.FGF
member entity reference: Fibroblast growth factor 10
member entity reference: Fibroblast growth factor
member entity reference: Fibroblast growth factor 6
member entity reference: Uncharacterized protein
member entity reference: Fibroblast growth factor 16
member entity reference: Fibroblast growth factor 17
member entity reference: Fibroblast growth factor 7
member entity reference: Fibroblast growth factor 2
member entity reference: Fibroblast growth factor 1
member entity reference: Fibroblast growth factor 18
member entity reference: Multifunctional fusion protein
member entity reference: Fibroblast growth factor 5
member entity reference: Fibroblast growth factor 3
member entity reference: Fibroblast growth factor 9
member entity reference: Fibroblast growth factor 8
member entity reference: Fibroblast growth factor 13
member entity reference: Fibroblast growth factor 12
member entity reference: Fibroblast growth factor 20

Rac1B, RHO family GTPase
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot F0ZQR3 1045
organism: Dictyostelium purpureum

uniprot B1NA68 826
type: UnificationXref
id: B1NA68
db: uniprot

uniprot F1A084 1046
type: UnificationXref
id: F1A084
db: uniprot

Extracellular signal-regulated kinase 1
type: ProteinReference
xref: uniprot Q5A1D3 348
xref: PTHR24055:SF158
organism: Candida albicans

uniprot P15655 86
type: UnificationXref
id: P15655
db: uniprot

uniprot Q38903 1071
type: UnificationXref
id: Q38903
db: uniprot

uniprot P29353 861
type: UnificationXref
id: P29353
db: uniprot

STATE_TRANSITION_LEFT__FGFR1_4-RIGHT__FGFR1_4-_r17
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 1255
participant stoichiometry: PARTICIPANT STOICHIOMETRY r17 1254
left: FGFR1-4
interaction type: STATE_TRANSITION
right: FGFR1-4

STATE_TRANSITION_LEFT__FGFR1_4-RIGHT__FGFR1_4-_r18
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1253
participant stoichiometry: PARTICIPANT STOICHIOMETRY r18 1252
left: FGFR1-4
interaction type: STATE_TRANSITION
right: FGFR1-4

uniprot F6QYV4 33
type: UnificationXref
id: F6QYV4
db: uniprot

Raf-1
type: Protein
entity reference: Raf-1
feature: Raf 1 s23 a26 rs3
feature: Raf 1 s23 a26 rs2
feature: Raf 1 s23 a26 rs4
feature: Raf 1 s23 a26 rs1
cellular location: cytoplasm
comment: SPECIES_TYPE=PROTEIN

uniprot Q61120 865
type: UnificationXref
id: Q61120
db: uniprot

uniprot Q7PX08 260
type: UnificationXref
id: Q7PX08
db: uniprot

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
type: ProteinReference
xref: PTHR10648:SF2
xref: uniprot Q76MZ3 572
organism: Mus musculus

uniprot P34149 1059
type: UnificationXref
id: P34149
db: uniprot

Rho family GTPase
type: ProteinReference
xref: PTHR24072:SF310
xref: uniprot C4M5T0 1041
organism: Entamoeba histolytica

Serine/threonine-protein phosphatase ppe1
type: ProteinReference
xref: uniprot P36614 504
organism: Schizosaccharomyces pombe

uniprot P48528 510
type: UnificationXref
id: P48528
db: uniprot

uniprot P22607 812
type: UnificationXref
id: P22607
db: uniprot

uniprot F6WG78 39
type: UnificationXref
id: F6WG78
db: uniprot

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
type: ProteinReference
xref: uniprot Q6PD28 569
xref: PTHR10257:SF4
organism: Mus musculus

Phaeosphaeria nodorum
type: BioSource
xref: ncbitaxon 321614 324

ncbitaxon 284812 207
type: UnificationXref
id: 284812
db: ncbitaxon

uniprot Q39022 343
type: UnificationXref
id: Q39022
db: uniprot

Fibroblast growth factor
type: ProteinReference
xref: uniprot J9NVD5 64
xref: PTHR11486:SF21
organism: Canis lupus familiaris

PTHR11362:SF10
type: RelationshipXref
id: PTHR11362:SF10
db: PANTHER Family
relationship type: By Homology

RKIP
type: ProteinReference
xref: P00630
standard name: Raf-1 kinase inhibitor protein
comment: ENTITY_REFERENCE_NOTES= Long Name: Raf-1 kinase inhibitor protein Synonym: PEBP,Phosphatidylethanolamine-binding protein Accession: P00630
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.RKIP
member entity reference: CEN-like protein 2, putative, expressed
member entity reference: Phosphatidylethanolamine-binding protein 1
member entity reference: Protein MOTHER of FT and TFL1 homolog 2
member entity reference: Phosphatidylethanolamine-binding protein 2
member entity reference: GH14494p
member entity reference: AGAP008909-PA
member entity reference: Uncharacterized protein
member entity reference: Protein CBG05964
member entity reference: GH28351p
member entity reference: Protein FLOWERING LOCUS T
member entity reference: CENTRORADIALIS, putative, expressed
member entity reference: AGAP002049-PA
member entity reference: Protein TERMINAL FLOWER 1
member entity reference: PEBP1 isoform 1
member entity reference: Phosphatidylethanolamine-binding protein 4
member entity reference: GH14779p
member entity reference: LP12095p
member entity reference: Protein TWIN SISTER of FT
member entity reference: Protein CENTRORADIALIS-like
member entity reference: GH25425p
member entity reference: Os01g0748800 protein
member entity reference: Protein RICE FLOWERING LOCUS T 1
member entity reference: Phosphatidylethanolamine-binding protein homolog F40A3.3
member entity reference: Putative odorant-binding protein A5
member entity reference: AGAP012962-PA
member entity reference: AGAP013036-PA
member entity reference: Protein HEADING DATE 3A

uniprot E2R2N2 321
type: UnificationXref
id: E2R2N2
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: PTHR18860:SF17
xref: uniprot F6TNW3 167
organism: Ciona intestinalis

uniprot P31044 623
type: UnificationXref
id: P31044
db: uniprot

uniprot Q63844 350
type: UnificationXref
id: Q63844
db: uniprot

uniprot Q5HZA2 306
type: UnificationXref
id: Q5HZA2
db: uniprot

uniprot E2REX2 21
type: UnificationXref
id: E2REX2
db: uniprot

uniprot F6YCI3 945
type: UnificationXref
id: F6YCI3
db: uniprot

uniprot O15520 68
type: UnificationXref
id: O15520
db: uniprot

ncbitaxon 45351 416
type: UnificationXref
id: 45351
db: ncbitaxon

uniprot F7AGV5 276
type: UnificationXref
id: F7AGV5
db: uniprot

Protein MOTHER of FT and TFL1 homolog 2
type: ProteinReference
xref: uniprot Q9ASJ1 635
organism: Oryza sativa

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
type: ProteinReference
xref: uniprot A0A2J8MKA4 137
xref: PTHR18860:SF28
organism: Pan troglodytes

Spry
type: ProteinReference
xref: P00626
standard name: sprouty
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES= Long Name: sprouty Synonym: antagonist of FGF signaling Accession: P00626
comment: ENTITY_REFERENCE_ID_DESC=FGF signaling pathway.PROTEIN.GENERIC.Spry
member entity reference: Sprouty RTK signaling antagonist 2
member entity reference: Protein sprouty homolog 4
member entity reference: Sprouty RTK signaling antagonist 4
member entity reference: Sprouty RTK-signaling antagonist 2
member entity reference: Protein sprouty homolog 1
member entity reference: Protein sprouty homolog 2
member entity reference: RCG49355
member entity reference: Protein sprouty homolog 3
member entity reference: Sprouty RTK signaling antagonist 3
member entity reference: Uncharacterized protein
member entity reference: SPRY1 isoform 1
member entity reference: RCG41526, isoform CRA_a
member entity reference: Sprouty homolog 4 (Drosophila)
member entity reference: Protein sprouty

Fibroblast growth factor
type: ProteinReference
xref: uniprot F7D846 43
organism: Monodelphis domestica

uniprot F7DNM3 1098
type: UnificationXref
id: F7DNM3
db: uniprot

uniprot F6ZB49 41
type: UnificationXref
id: F6ZB49
db: uniprot

Ras-related protein Rac2
type: ProteinReference
xref: PTHR24072:SF281
xref: uniprot P48554 1061
organism: Drosophila melanogaster

PIK3CG isoform 1
type: ProteinReference
xref: PTHR10048:SF34
xref: uniprot A0A2J8QY32 875
organism: Pan troglodytes

Ras guanine nucleotide exchange factor Y
type: ProteinReference
xref: uniprot Q552M5 955
organism: Dictyostelium discoideum

uniprot P32253 720
type: UnificationXref
id: P32253
db: uniprot

ncbitaxon 7955 29
type: UnificationXref
id: 7955
db: ncbitaxon

uniprot P26675 950
type: UnificationXref
id: P26675
db: uniprot