LOC100170462 protein
type: ProteinReference
xref: uniprot B3DL74 8
organism: Xenopus tropicalis

Uncharacterized protein
type: ProteinReference
xref: uniprot H2QTW9 22
organism: Pan troglodytes

STATE_TRANSITION_LEFT__NADPH-_5,10_methylenetetrahydrofolate-RIGHT__NADP-_5_methyltetrahydrofolate_-_r3
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 169
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 167
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 170
participant stoichiometry: PARTICIPANT STOICHIOMETRY r3 168
left: 5,10-methylenetetrahydrofolate
left: NADPH
interaction type: STATE_TRANSITION
right: 5-methyltetrahydrofolate
right: NADP

uniprot Q09582 75
type: UnificationXref
id: Q09582
db: uniprot

uniprot H2QI58 20
type: UnificationXref
id: H2QI58
db: uniprot

uniprot Q9RXH3 165
type: UnificationXref
id: Q9RXH3
db: uniprot

formate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dihydrofolate reductase 2, mitochondrial
type: ProteinReference
xref: uniprot Q86XF0 151
organism: Homo sapiens

ncbitaxon 9615 15
type: UnificationXref
id: 9615
db: ncbitaxon

uniprot P13995 31
type: UnificationXref
id: P13995
db: uniprot

Mus musculus
type: BioSource
xref: ncbitaxon 10090 34

uniprot Q5ZBZ6 81
type: UnificationXref
id: Q5ZBZ6
db: uniprot

uniprot Q9VJ32 94
type: UnificationXref
id: Q9VJ32
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: P02954
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Thymidylate synthase Synonym: Synonym not specified Accession: P02954
comment: ENTITY_REFERENCE_ID_DESC=Formyltetrahydroformate biosynthesis.PROTEIN.GENERIC.Thymidylate synthase
member entity reference: Thymidylate synthase
member entity reference: Probable thymidylate synthase
member entity reference: Bifunctional dihydrofolate reductase-thymidylate synthase
member entity reference: Thymidylate synthase 1
member entity reference: Bifunctional dihydrofolate reductase-thymidylate synthase 1
member entity reference: Thymidylate synthase ThyA
member entity reference: AGAP010457-PA
member entity reference: Thymidylate synthase 2
member entity reference: Fibronectin 1
member entity reference: Uncharacterized protein
member entity reference: Thymidylate synthetase

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P17719 146
organism: Drosophila melanogaster

5,10-methylenetetrahydrofolate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Saccharomyces cerevisiae
type: BioSource
xref: ncbitaxon 559292 77

ncbitaxon 243230 63
type: UnificationXref
id: 243230
db: ncbitaxon

Bifunctional protein FolD
type: ProteinReference
xref: uniprot P54382 37
organism: Bacillus subtilis

ncbitaxon 208964 58
type: UnificationXref
id: 208964
db: ncbitaxon

uniprot A2RVV7 4
type: UnificationXref
id: A2RVV7
db: uniprot

uniprot Q05762 114
type: UnificationXref
id: Q05762
db: uniprot

Drosophila melanogaster
type: BioSource
xref: ncbitaxon 7227 30

uniprot P04818 100
type: UnificationXref
id: P04818
db: uniprot

uniprot P9WG81 39
type: UnificationXref
id: P9WG81
db: uniprot

uniprot P07607 104
type: UnificationXref
id: P07607
db: uniprot

uniprot Q47690 78
type: UnificationXref
id: Q47690
db: uniprot

Methylene tetrahydrofolate dehydrogenase
type: ProteinReference
xref: P02952
standard name: Methylenetetrahydrofolate dehydrogenase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_NOTES=Long Name: Methylenetetrahydrofolate dehydrogenase Synonym: Synonym not specified Accession: P02952
comment: ENTITY_REFERENCE_ID_DESC=Formyltetrahydroformate biosynthesis.PROTEIN.GENERIC.Methylene tetrahydrofolate_br_dehydrogenase
member entity reference: Bifunctional protein FolD
member entity reference: Uncharacterized protein
member entity reference: Monofunctional C1-tetrahydrofolate synthase, mitochondrial
member entity reference: Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
member entity reference: LOC100170462 protein
member entity reference: Bifunctional protein FolD 1, mitochondrial
member entity reference: Bifunctional protein FolD 2
member entity reference: Os05g0150800 protein
member entity reference: Bifunctional protein FolD 3, chloroplastic
member entity reference: Bifunctional protein FolD 4, chloroplastic
member entity reference: C1-tetrahydrofolate synthase, putative (Fragment)
member entity reference: Protein CBR-DAO-3
member entity reference: Dauer or Aging adult Overexpression
member entity reference: Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 2, methenyltetrahydrofolate cyclohydrolase
member entity reference: C-1-tetrahydrofolate synthase, cytoplasmic
member entity reference: MTHFD2 isoform 1

Bifunctional protein FolD
type: ProteinReference
xref: uniprot Q8ZZK1 53
organism: Pyrobaculum aerophilum

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__ATP-_7,8_dihydropteroate-_glutamate-RIGHT__7,8_DHF-_PO4-_ADP-_r13
controller: Dihydrofolate synthase

uniprot Q9HPY4 55
type: UnificationXref
id: Q9HPY4
db: uniprot

Thymidylate synthase 2
type: ProteinReference
xref: uniprot P11044 109
organism: Bacillus subtilis

Bifunctional protein FolD
type: ProteinReference
xref: uniprot Q9X288 64
organism: Thermotoga maritima

uniprot P0A884 105
type: UnificationXref
id: P0A884
db: uniprot

STATE_TRANSITION_LEFT__homocysteine-_5_methyltetrahydrofolate_-RIGHT__methionine-_THF-_r4
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 198
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 197
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 196
participant stoichiometry: PARTICIPANT STOICHIOMETRY r4 199
left: 5-methyltetrahydrofolate
left: homocysteine
interaction type: STATE_TRANSITION
right: methionine
right: THF

PANTHER Pathway P02743 1
type: UnificationXref
id: P02743
db: PANTHER Pathway

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P11045 145
organism: Bacillus subtilis

Homocysteine S-methyltransferase 1
type: ProteinReference
xref: uniprot Q9SDL7 92
organism: Arabidopsis thaliana

Plasmodium falciparum
type: BioSource
xref: ncbitaxon 36329 121

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
type: ProteinReference
xref: uniprot A0A452DI11 2
organism: Bos taurus

uniprot Q93341 153
type: UnificationXref
id: Q93341
db: uniprot

Formyl tetrahydrofolate deformylase
type: ProteinReference
xref: P02956
standard name: Formyltetrahydrofolate deformylase
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Formyltetrahydroformate biosynthesis.PROTEIN.GENERIC.Formyl tetrahydrofolate_br_deformylase
comment: ENTITY_REFERENCE_NOTES=Long Name: Formyltetrahydrofolate deformylase Synonym: Synonym not specified Accession: P02956
member entity reference: Formyltetrahydrofolate deformylase

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__7,8_DHF-_NADPH-RIGHT__NADP-_THF-_r12
controller: Dihydrofolate reductase

ncbitaxon 7955 118
type: UnificationXref
id: 7955
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__H2O-_10_formyl_THF-RIGHT__formate-_THF-_r7
controller: Formyl tetrahydrofolate deformylase

uniprot O31463 71
type: UnificationXref
id: O31463
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: uniprot Q8RGP6 122
organism: Fusobacterium nucleatum

10-formyl-THF
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 9913 3
type: UnificationXref
id: 9913
db: ncbitaxon

ncbitaxon 36329 121
type: UnificationXref
id: 36329
db: ncbitaxon

uniprot Q55786 80
type: UnificationXref
id: Q55786
db: uniprot

ncbitaxon 1111708 45
type: UnificationXref
id: 1111708
db: ncbitaxon

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
type: ProteinReference
xref: uniprot Q04448 41
organism: Drosophila melanogaster

uniprot O65271 24
type: UnificationXref
id: O65271
db: uniprot

ncbitaxon 188937 52
type: UnificationXref
id: 188937
db: ncbitaxon

Pan troglodytes
type: BioSource
xref: ncbitaxon 9598 21

Uncharacterized protein
type: ProteinReference
xref: uniprot F6SNN4 139
organism: Macaca mulatta

Xenopus tropicalis
type: BioSource
xref: ncbitaxon 8364 9

Uncharacterized protein
type: ProteinReference
xref: uniprot F1PH90 16
organism: Canis lupus familiaris

dUMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

ncbitaxon 185431 116
type: UnificationXref
id: 185431
db: ncbitaxon

uniprot Q21285 42
type: UnificationXref
id: Q21285
db: uniprot

Methionine synthase
type: ProteinReference
xref: uniprot Q9Z2Q4 96
organism: Rattus norvegicus

uniprot Q8TK95 51
type: UnificationXref
id: Q8TK95
db: uniprot

uniprot O67681 130
type: UnificationXref
id: O67681
db: uniprot

uniprot P06785 101
type: UnificationXref
id: P06785
db: uniprot

glutamate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P00374 141
type: UnificationXref
id: P00374
db: uniprot

STATE_TRANSITION_LEFT__dUMP-_5,10_methylenetetrahydrofolate-RIGHT__7,8_DHF-_dTMP-_r11
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 193
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 195
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 194
participant stoichiometry: PARTICIPANT STOICHIOMETRY r11 192
left: 5,10-methylenetetrahydrofolate
left: dUMP
interaction type: STATE_TRANSITION
right: dTMP
right: 7,8-DHF

Formyltetrahydrofolate deformylase
type: ProteinReference
xref: uniprot P37051 131
organism: Escherichia coli

uniprot Q8RDM4 49
type: UnificationXref
id: Q8RDM4
db: uniprot

uniprot Q9UTI7 127
type: UnificationXref
id: Q9UTI7
db: uniprot

THF
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q07801 149
type: UnificationXref
id: Q07801
db: uniprot

Methionine synthase
type: ProteinReference
xref: uniprot H2R7Z7 69
organism: Pan troglodytes

ncbitaxon 243274 65
type: UnificationXref
id: 243274
db: ncbitaxon

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADP-_5,10_methylenetetrahydrofolate-RIGHT__5,10_methenyl_THF-_NADPH-_r5
controller: Methylene tetrahydrofolate dehydrogenase

uniprot P08192 158
type: UnificationXref
id: P08192
db: uniprot

uniprot P36591 147
type: UnificationXref
id: P36591
db: uniprot

STATE_TRANSITION_LEFT__NADP-_5,10_methylenetetrahydrofolate-RIGHT__5,10_methenyl_THF-_NADPH-_r5
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 190
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 189
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 191
participant stoichiometry: PARTICIPANT STOICHIOMETRY r5 188
left: 5,10-methylenetetrahydrofolate
left: NADP
interaction type: STATE_TRANSITION
right: 5,10-methenyl-THF
right: NADPH

Dihydrofolate reductase
type: ProteinReference
xref: uniprot A2BGQ1 138
organism: Danio rerio

Folylpolyglutamate synthase/dihydrofolate synthase
type: ProteinReference
xref: uniprot Q9WY13 166
organism: Thermotoga maritima

Thymidylate synthase
type: ProteinReference
xref: uniprot P04818 100
organism: Homo sapiens

Putative transferase
type: ProteinReference
xref: uniprot Q8CJP1 84
organism: Streptomyces coelicolor

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q9L1G4 164
organism: Streptomyces coelicolor

STATE_TRANSITION_LEFT__5,10_methenyl_THF-_H2O-RIGHT__10_formyl_THF-_r6
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 182
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 181
participant stoichiometry: PARTICIPANT STOICHIOMETRY r6 183
left: 5,10-methenyl-THF
left: H2O
interaction type: STATE_TRANSITION
right: 10-formyl-THF

Methylene tetrahydrofolate dehydrogenase
type: Protein
entity reference: Methylene tetrahydrofolate dehydrogenase
comment: SPECIES_TYPE=PROTEIN

Bifunctional protein FolD
type: ProteinReference
xref: uniprot Q8TK95 51
organism: Methanosarcina acetivorans

ncbitaxon 10116 13
type: UnificationXref
id: 10116
db: ncbitaxon

uniprot A0A452DI11 2
type: UnificationXref
id: A0A452DI11
db: uniprot

AGAP010457-PA
type: ProteinReference
xref: uniprot Q7QDW7 119
organism: Anopheles gambiae

uniprot H2QTW9 22
type: UnificationXref
id: H2QTW9
db: uniprot

ncbitaxon 224324 26
type: UnificationXref
id: 224324
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r6 183
type: Stoichiometry
physical entity: 10-formyl-THF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 181
type: Stoichiometry
physical entity: 5,10-methenyl-THF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r6 182
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

C-1-tetrahydrofolate synthase, cytoplasmic
type: ProteinReference
xref: uniprot O96553 29
organism: Drosophila melanogaster

uniprot Q8W035 162
type: UnificationXref
id: Q8W035
db: uniprot

uniprot P0CI79 106
type: UnificationXref
id: P0CI79
db: uniprot

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot P07382 102
organism: Leishmania major

Dihydrofolate reductase
type: ProteinReference
xref: uniprot Q07801 149
organism: Cryptococcus neoformans

Dihydrofolate synthase
type: ProteinReference
xref: P02958
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Formyltetrahydroformate biosynthesis.PROTEIN.GENERIC.Dihydrofolate synthase
comment: ENTITY_REFERENCE_NOTES=Long Name: Dihydrofolate synthase Synonym: Synonym not specified Accession: P02958
member entity reference: Folylpolyglutamate synthase
member entity reference: Folylpolyglutamate synthase/dihydrofolate synthase
member entity reference: Folyl-polyglutamate synthetase
member entity reference: Dihydrofolate synthase/folylpolyglutamate synthase
member entity reference: Folylpolyglutamate synthetase

7,8-DHF
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Methionine synthase
type: ProteinReference
xref: uniprot Q9EWH3 88
organism: Streptomyces coelicolor

Thymidylate synthase
type: ProteinReference
xref: uniprot O76511 99
organism: Drosophila melanogaster

uniprot P0CS12 107
type: UnificationXref
id: P0CS12
db: uniprot

Bifunctional protein FolD
type: ProteinReference
xref: uniprot Q55626 44
organism: Synechocystis

Dihydrofolate synthase/folylpolyglutamate synthase
type: ProteinReference
xref: uniprot P08192 158
organism: Escherichia coli

Dihydrofolate reductase
type: ProteinReference
xref: uniprot Q920D2 152
organism: Rattus norvegicus

Formyltetrahydrofolate deformylase
type: ProteinReference
xref: uniprot Q9HW87 136
organism: Pseudomonas aeruginosa

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__homocysteine-_5_methyltetrahydrofolate_-RIGHT__methionine-_THF-_r4
controller: Cobalamin dependent homocysteine transmethylase

PARTICIPANT STOICHIOMETRY r11 193
type: Stoichiometry
physical entity: 5,10-methylenetetrahydrofolate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 192
type: Stoichiometry
physical entity: dUMP
stoichiometric coefficient: 1.0

uniprot O33259 72
type: UnificationXref
id: O33259
db: uniprot

dTMP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

PARTICIPANT STOICHIOMETRY r11 195
type: Stoichiometry
physical entity: dTMP
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r11 194
type: Stoichiometry
physical entity: 7,8-DHF
stoichiometric coefficient: 1.0

Homocysteine S-methyltransferase 3
type: ProteinReference
xref: uniprot Q8LAX0 85
organism: Arabidopsis thaliana

Methionine synthase
type: ProteinReference
xref: uniprot Q55786 80
organism: Synechocystis

Dihydrofolate synthase/folylpolyglutamate synthase
type: ProteinReference
xref: uniprot I6Y0R5 157
organism: Mycobacterium tuberculosis

Bacillus subtilis
type: BioSource
xref: ncbitaxon 224308 38

Bos taurus
type: BioSource
xref: ncbitaxon 9913 3

Uncharacterized protein
type: ProteinReference
xref: uniprot F6Q8U4 17
organism: Macaca mulatta

PARTICIPANT STOICHIOMETRY r7 173
type: Stoichiometry
physical entity: formate
stoichiometric coefficient: 1.0

Macaca mulatta
type: BioSource
xref: ncbitaxon 9544 18

PARTICIPANT STOICHIOMETRY r7 174
type: Stoichiometry
physical entity: THF
stoichiometric coefficient: 1.0

uniprot F6SNN4 139
type: UnificationXref
id: F6SNN4
db: uniprot

PARTICIPANT STOICHIOMETRY r7 172
type: Stoichiometry
physical entity: 10-formyl-THF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r7 171
type: Stoichiometry
physical entity: H2O
stoichiometric coefficient: 1.0

Methionine synthase
type: ProteinReference
xref: uniprot G7MFM9 68
organism: Macaca mulatta

Thymidylate synthase
type: ProteinReference
xref: uniprot P07607 104
organism: Mus musculus

5-methyltetrahydrofolate--homocysteine methyltransferase
type: ProteinReference
xref: uniprot Q8RGW4 86
organism: Fusobacterium nucleatum

uniprot Q9L1G4 164
type: UnificationXref
id: Q9L1G4
db: uniprot

DHFR isoform 1
type: ProteinReference
xref: uniprot H2QR61 140
organism: Pan troglodytes

Monofunctional C1-tetrahydrofolate synthase, mitochondrial
type: ProteinReference
xref: uniprot Q6UB35 48
organism: Homo sapiens

Methanosarcina acetivorans
type: BioSource
xref: ncbitaxon 188937 52

Ixodes scapularis
type: BioSource
xref: ncbitaxon 6945 11

ATP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Thymidylate synthase
type: ProteinReference
xref: uniprot P0A884 105
organism: Escherichia coli

PARTICIPANT STOICHIOMETRY r3 167
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

Methionine synthase
type: ProteinReference
xref: uniprot A6H5Y3 66
organism: Mus musculus

Bifunctional protein FolD
type: ProteinReference
xref: uniprot Q9K3J6 59
organism: Streptomyces coelicolor

PARTICIPANT STOICHIOMETRY r3 168
type: Stoichiometry
physical entity: 5,10-methylenetetrahydrofolate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r3 169
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

uniprot O06745 70
type: UnificationXref
id: O06745
db: uniprot

MTHFD2 isoform 1
type: ProteinReference
xref: uniprot H2QI58 20
organism: Pan troglodytes

Aquifex aeolicus
type: BioSource
xref: ncbitaxon 224324 26

Bifunctional protein FolD
type: ProteinReference
xref: uniprot P9WG81 39
organism: Mycobacterium tuberculosis

Canis lupus familiaris
type: BioSource
xref: ncbitaxon 9615 15

uniprot Q9RR67 125
type: UnificationXref
id: Q9RR67
db: uniprot

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q337F3 160
organism: Oryza sativa

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P9WNX1 148
organism: Mycobacterium tuberculosis

Cobalamin dependent homocysteine transmethylase
type: ProteinReference
xref: P02953
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Formyltetrahydroformate biosynthesis.PROTEIN.GENERIC.Cobalamin dependent_br_homocysteine transmethylase
comment: ENTITY_REFERENCE_NOTES=Long Name: Cobalamin dependent homocysteine transmethylase Synonym: Synonym not specified Accession: P02953
member entity reference: 5-methyltetrahydrofolate S-homocysteine methyltransferase
member entity reference: Os01g0772900 protein
member entity reference: Homocysteine S-methyltransferase 3
member entity reference: Methionine synthase
member entity reference: Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase
member entity reference: Putative transferase
member entity reference: CG10623 protein
member entity reference: Homocysteine S-methyltransferase
member entity reference: Probable homocysteine S-methyltransferase MmuM (S-methylmethionine:homocysteine methyltransferase) (Cysteine methyltransferase)
member entity reference: 5-methyltetrahydrofolate--homocysteine methyltransferase
member entity reference: Homocysteine S-methyltransferase 1
member entity reference: Probable methionine synthase
member entity reference: FI01821p
member entity reference: Homocysteine S-methyltransferase YbgG
member entity reference: AGAP008537-PA (Fragment)
member entity reference: Homocysteine S-methyltransferase 2

ncbitaxon 7227 30
type: UnificationXref
id: 7227
db: ncbitaxon

ncbitaxon 9606 32
type: UnificationXref
id: 9606
db: ncbitaxon

uniprot Q04448 41
type: UnificationXref
id: Q04448
db: uniprot

Bifunctional protein FolD
type: ProteinReference
xref: uniprot Q9RW02 62
organism: Deinococcus radiodurans

Bifunctional protein FolD 2
type: ProteinReference
xref: uniprot Q9LHH7 61
organism: Arabidopsis thaliana

Pyrobaculum aerophilum
type: BioSource
xref: ncbitaxon 178306 54

ncbitaxon 39947 47
type: UnificationXref
id: 39947
db: ncbitaxon

5-methyltetrahydrofolate S-homocysteine methyltransferase
type: ProteinReference
xref: uniprot Q9WYA5 95
organism: Thermotoga maritima

uniprot Q8ZZK1 53
type: UnificationXref
id: Q8ZZK1
db: uniprot

Thymidylate synthase
type: ProteinReference
xref: uniprot P12461 110
organism: Candida albicans

uniprot Q99707 87
type: UnificationXref
id: Q99707
db: uniprot

Streptomyces coelicolor
type: BioSource
xref: ncbitaxon 100226 60

uniprot Q9K3J6 59
type: UnificationXref
id: Q9K3J6
db: uniprot

Methionine synthase
type: ProteinReference
xref: uniprot O33259 72
organism: Mycobacterium tuberculosis

uniprot P07382 102
type: UnificationXref
id: P07382
db: uniprot

uniprot F6Q8U4 17
type: UnificationXref
id: F6Q8U4
db: uniprot

P02956
type: UnificationXref
id: P02956
db: PANTHER Pathway Component

P02957
type: UnificationXref
id: P02957
db: PANTHER Pathway Component

P02958
type: UnificationXref
id: P02958
db: PANTHER Pathway Component

uniprot Q4JIJ3 79
type: UnificationXref
id: Q4JIJ3
db: uniprot

P02952
type: UnificationXref
id: P02952
db: PANTHER Pathway Component

P02953
type: UnificationXref
id: P02953
db: PANTHER Pathway Component

Formyltetrahydrofolate deformylase
type: ProteinReference
xref: uniprot Q9RWT1 137
organism: Deinococcus radiodurans

P02954
type: UnificationXref
id: P02954
db: PANTHER Pathway Component

PARTICIPANT STOICHIOMETRY r12 185
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 184
type: Stoichiometry
physical entity: 7,8-DHF
stoichiometric coefficient: 1.0

uniprot F1PH90 16
type: UnificationXref
id: F1PH90
db: uniprot

PARTICIPANT STOICHIOMETRY r12 187
type: Stoichiometry
physical entity: THF
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r12 186
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

STATE_TRANSITION
type: RelationshipTypeVocabulary

Thymidylate synthetase
type: ProteinReference
xref: uniprot Q6P045 117
organism: Danio rerio

ncbitaxon 284812 128
type: UnificationXref
id: 284812
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r3 170
type: Stoichiometry
physical entity: 5-methyltetrahydrofolate
stoichiometric coefficient: 1.0

Methionine synthase
type: ProteinReference
xref: uniprot Q9RVQ6 91
organism: Deinococcus radiodurans

Homocysteine S-methyltransferase 1
type: ProteinReference
xref: uniprot Q12525 76
organism: Saccharomyces cerevisiae

uniprot O65269 23
type: UnificationXref
id: O65269
db: uniprot

uniprot Q8RGW4 86
type: UnificationXref
id: Q8RGW4
db: uniprot

ncbitaxon 6239 43
type: UnificationXref
id: 6239
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r13 180
type: Stoichiometry
physical entity: ADP
stoichiometric coefficient: 1.0

5,10-methenyl-THF
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

AGAP010278-PA
type: ProteinReference
xref: uniprot Q7Q0L5 150
organism: Anopheles gambiae

uniprot Q9N588 124
type: UnificationXref
id: Q9N588
db: uniprot

Os01g0772900 protein
type: ProteinReference
xref: uniprot Q5ZBZ6 81
organism: Oryza sativa

STATE_TRANSITION_LEFT__ATP-_7,8_dihydropteroate-_glutamate-RIGHT__7,8_DHF-_PO4-_ADP-_r13
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 180
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 176
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 175
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 178
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 177
participant stoichiometry: PARTICIPANT STOICHIOMETRY r13 179
left: ATP
left: glutamate
left: 7,8-dihydropteroate
interaction type: STATE_TRANSITION
right: PO4
right: ADP
right: 7,8-DHF

uniprot P24186 35
type: UnificationXref
id: P24186
db: uniprot

Probable methionine synthase
type: ProteinReference
xref: uniprot Q09582 75
organism: Caenorhabditis elegans

Caenorhabditis briggsae
type: BioSource
xref: ncbitaxon 6238 7

Thymidylate synthase
type: ProteinReference
xref: uniprot Q9N588 124
organism: Caenorhabditis elegans

uniprot Q6UB35 48
type: UnificationXref
id: Q6UB35
db: uniprot

Dauer or Aging adult Overexpression
type: ProteinReference
xref: uniprot Q21285 42
organism: Caenorhabditis elegans

Caenorhabditis elegans
type: BioSource
xref: ncbitaxon 6239 43

NADPH
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9HTE4 135
type: UnificationXref
id: Q9HTE4
db: uniprot

uniprot Q9I2Q2 89
type: UnificationXref
id: Q9I2Q2
db: uniprot

Methionine synthase
type: ProteinReference
xref: uniprot P13009 74
organism: Escherichia coli

uniprot P18155 33
type: UnificationXref
id: P18155
db: uniprot

uniprot F6ZRA0 97
type: UnificationXref
id: F6ZRA0
db: uniprot

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__dUMP-_5,10_methylenetetrahydrofolate-RIGHT__7,8_DHF-_dTMP-_r11
controller: Thymidylate synthase

PARTICIPANT STOICHIOMETRY r13 175
type: Stoichiometry
physical entity: ATP
stoichiometric coefficient: 1.0

ncbitaxon 7165 83
type: UnificationXref
id: 7165
db: ncbitaxon

uniprot Q8RES8 161
type: UnificationXref
id: Q8RES8
db: uniprot

PARTICIPANT STOICHIOMETRY r13 177
type: Stoichiometry
physical entity: glutamate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 176
type: Stoichiometry
physical entity: 7,8-dihydropteroate
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 179
type: Stoichiometry
physical entity: PO4
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r13 178
type: Stoichiometry
physical entity: 7,8-DHF
stoichiometric coefficient: 1.0

AGAP008537-PA (Fragment)
type: ProteinReference
xref: uniprot Q7PNI0 82
organism: Anopheles gambiae

Methionine synthase
type: ProteinReference
xref: uniprot Q99707 87
organism: Homo sapiens

ncbitaxon 5664 103
type: UnificationXref
id: 5664
db: ncbitaxon

ncbitaxon 83332 40
type: UnificationXref
id: 83332
db: ncbitaxon

ncbitaxon 178306 54
type: UnificationXref
id: 178306
db: ncbitaxon

uniprot Q9HZA8 163
type: UnificationXref
id: Q9HZA8
db: uniprot

Oryza sativa
type: BioSource
xref: ncbitaxon 39947 47

Probable thymidylate synthase
type: ProteinReference
xref: uniprot Q9UTI7 127
organism: Schizosaccharomyces pombe

Pseudomonas aeruginosa
type: BioSource
xref: ncbitaxon 208964 58

uniprot O53185 73
type: UnificationXref
id: O53185
db: uniprot

5-methyltetrahydrofolate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RVQ6 91
type: UnificationXref
id: Q9RVQ6
db: uniprot

uniprot P9WNX1 148
type: UnificationXref
id: P9WNX1
db: uniprot

uniprot P13009 74
type: UnificationXref
id: P13009
db: uniprot

Halobacterium salinarum
type: BioSource
xref: ncbitaxon 64091 56

uniprot Q8CJP1 84
type: UnificationXref
id: Q8CJP1
db: uniprot

ncbitaxon 100226 60
type: UnificationXref
id: 100226
db: ncbitaxon

ncbitaxon 559292 77
type: UnificationXref
id: 559292
db: ncbitaxon

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot Q582G3 115
organism: Trypanosoma brucei

uniprot Q55626 44
type: UnificationXref
id: Q55626
db: uniprot

Homocysteine S-methyltransferase
type: ProteinReference
xref: uniprot Q47690 78
organism: Escherichia coli

uniprot Q12525 76
type: UnificationXref
id: Q12525
db: uniprot

Bifunctional protein FolD
type: ProteinReference
xref: uniprot O84081 27
organism: Chlamydia trachomatis

uniprot P9WFR9 113
type: UnificationXref
id: P9WFR9
db: uniprot

uniprot Q9WYA5 95
type: UnificationXref
id: Q9WYA5
db: uniprot

Anopheles gambiae
type: BioSource
xref: ncbitaxon 7165 83

Cryptococcus neoformans
type: BioSource
xref: ncbitaxon 214684 108

uniprot Q9RW02 62
type: UnificationXref
id: Q9RW02
db: uniprot

uniprot Q6P045 117
type: UnificationXref
id: Q6P045
db: uniprot

uniprot A2BGQ1 138
type: UnificationXref
id: A2BGQ1
db: uniprot

Dihydrofolate synthase
type: Protein
entity reference: Dihydrofolate synthase
comment: SPECIES_TYPE=PROTEIN

uniprot I6Y0R5 157
type: UnificationXref
id: I6Y0R5
db: uniprot

C1-tetrahydrofolate synthase, putative (Fragment)
type: ProteinReference
xref: uniprot B7P898 10
organism: Ixodes scapularis

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__NADPH-_5,10_methylenetetrahydrofolate-RIGHT__NADP-_5_methyltetrahydrofolate_-_r3
controller: 5,10-Methylene tetrahydrofolate reductase

Chlamydia trachomatis
type: BioSource
xref: ncbitaxon 272561 28

Thermotoga maritima
type: BioSource
xref: ncbitaxon 243274 65

Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase
type: ProteinReference
xref: uniprot O06745 70
organism: Bacillus subtilis

uniprot P11045 145
type: UnificationXref
id: P11045
db: uniprot

Homocysteine S-methyltransferase YbgG
type: ProteinReference
xref: uniprot O31463 71
organism: Bacillus subtilis

uniprot Q9LHH7 61
type: UnificationXref
id: Q9LHH7
db: uniprot

uniprot P00376 143
type: UnificationXref
id: P00376
db: uniprot

uniprot G7MFM9 68
type: UnificationXref
id: G7MFM9
db: uniprot

PARTICIPANT STOICHIOMETRY r5 188
type: Stoichiometry
physical entity: NADP
stoichiometric coefficient: 1.0

Protein CBR-DAO-3
type: ProteinReference
xref: uniprot A8XQ07 6
organism: Caenorhabditis briggsae

PARTICIPANT STOICHIOMETRY r5 189
type: Stoichiometry
physical entity: 5,10-methylenetetrahydrofolate
stoichiometric coefficient: 1.0

uniprot P00375 142
type: UnificationXref
id: P00375
db: uniprot

uniprot Q337F3 160
type: UnificationXref
id: Q337F3
db: uniprot

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q8RES8 161
organism: Fusobacterium nucleatum

uniprot Q86XF0 151
type: UnificationXref
id: Q86XF0
db: uniprot

Synechocystis
type: BioSource
xref: ncbitaxon 1111708 45

ADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q05865 159
type: UnificationXref
id: Q05865
db: uniprot

PARTICIPANT STOICHIOMETRY r5 191
type: Stoichiometry
physical entity: NADPH
stoichiometric coefficient: 1.0

PARTICIPANT STOICHIOMETRY r5 190
type: Stoichiometry
physical entity: 5,10-methenyl-THF
stoichiometric coefficient: 1.0

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q8W035 162
organism: Arabidopsis thaliana

Bifunctional protein FolD
type: ProteinReference
xref: uniprot O67736 25
organism: Aquifex aeolicus

STATE_TRANSITION_LEFT__7,8_DHF-_NADPH-RIGHT__NADP-_THF-_r12
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 187
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 184
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 186
participant stoichiometry: PARTICIPANT STOICHIOMETRY r12 185
left: NADPH
left: 7,8-DHF
interaction type: STATE_TRANSITION
right: THF
right: NADP

Probable homocysteine S-methyltransferase MmuM (S-methylmethionine:homocysteine methyltransferase) (Cysteine methyltransferase)
type: ProteinReference
xref: uniprot O53185 73
organism: Mycobacterium tuberculosis

Thymidylate synthase
type: ProteinReference
xref: uniprot P0CS12 107
organism: Cryptococcus neoformans

ncbitaxon 3702 5
type: UnificationXref
id: 3702
db: ncbitaxon

uniprot Q8LAX0 85
type: UnificationXref
id: Q8LAX0
db: uniprot

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot Q9SIK4 126
organism: Arabidopsis thaliana

uniprot Q9HW87 136
type: UnificationXref
id: Q9HW87
db: uniprot

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P07807 144
organism: Saccharomyces cerevisiae

uniprot Q9I6F1 123
type: UnificationXref
id: Q9I6F1
db: uniprot

Formyltetrahydrofolate deformylase
type: ProteinReference
xref: uniprot Q55135 133
organism: Synechocystis

Thymidylate synthase ThyA
type: ProteinReference
xref: uniprot P9WFR9 113
organism: Mycobacterium tuberculosis

uniprot P17719 146
type: UnificationXref
id: P17719
db: uniprot

Bifunctional protein FolD
type: ProteinReference
xref: uniprot Q8RDM4 49
organism: Fusobacterium nucleatum

Dihydrofolate reductase
type: ProteinReference
xref: uniprot Q9RR65 155
organism: Deinococcus radiodurans

Uncharacterized protein
type: ProteinReference
xref: uniprot F7G8N5 19
organism: Macaca mulatta

Thymidylate synthase
type: ProteinReference
xref: uniprot Q9RR67 125
organism: Deinococcus radiodurans

Folylpolyglutamate synthase
type: ProteinReference
xref: uniprot F4J2K2 156
organism: Arabidopsis thaliana

Methionine synthase
type: ProteinReference
xref: uniprot Q4JIJ3 79
organism: Bos taurus

ncbitaxon 10090 34
type: UnificationXref
id: 10090
db: ncbitaxon

Formyltetrahydrofolate deformylase
type: ProteinReference
xref: uniprot O34990 129
organism: Bacillus subtilis

Methionine synthase
type: ProteinReference
xref: uniprot Q9I2Q2 89
organism: Pseudomonas aeruginosa

Schizosaccharomyces pombe
type: BioSource
xref: ncbitaxon 284812 128

Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 2, methenyltetrahydrofolate cyclohydrolase
type: ProteinReference
xref: uniprot D4A1Y5 12
organism: Rattus norvegicus

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P00374 141
organism: Homo sapiens

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P00375 142
organism: Mus musculus

Putative dihydrofolate reductase
type: ProteinReference
xref: uniprot Q93341 153
organism: Caenorhabditis elegans

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P00376 143
organism: Bos taurus

Formyltetrahydroformate biosynthesis
type: Pathway
pathway component: STATE_TRANSITION_LEFT__NADPH-_5,10_methylenetetrahydrofolate-RIGHT__NADP-_5_methyltetrahydrofolate_-_r3
pathway component: STATE_TRANSITION_LEFT__homocysteine-_5_methyltetrahydrofolate_-RIGHT__methionine-_THF-_r4
pathway component: STATE_TRANSITION_LEFT__dUMP-_5,10_methylenetetrahydrofolate-RIGHT__7,8_DHF-_dTMP-_r11
pathway component: STATE_TRANSITION_LEFT__ATP-_7,8_dihydropteroate-_glutamate-RIGHT__7,8_DHF-_PO4-_ADP-_r13
pathway component: STATE_TRANSITION_LEFT__H2O-_10_formyl_THF-RIGHT__formate-_THF-_r7
pathway component: STATE_TRANSITION_LEFT__NADP-_5,10_methylenetetrahydrofolate-RIGHT__5,10_methenyl_THF-_NADPH-_r5
pathway component: STATE_TRANSITION_LEFT__7,8_DHF-_NADPH-RIGHT__NADP-_THF-_r12
pathway component: STATE_TRANSITION_LEFT__5,10_methenyl_THF-_H2O-RIGHT__10_formyl_THF-_r6
xref: PANTHER Pathway P02743 1
comment: MODEL_NOTES=The biosynthesis of the cofactor formyltetrahydrofolate that functions in formyl group transfer reactions. Website=www.biocyc.org/Ecoli/Pathways/ free text=Voet and Voet (textbook) Biochemistry

Bifunctional dihydrofolate reductase-thymidylate synthase
type: ProteinReference
xref: uniprot Q8I1R6 120
organism: Plasmodium falciparum

uniprot E2R716 67
type: UnificationXref
id: E2R716
db: uniprot

uniprot Q7PNI0 82
type: UnificationXref
id: Q7PNI0
db: uniprot

uniprot Q9VJ31 93
type: UnificationXref
id: Q9VJ31
db: uniprot

ncbitaxon 8364 9
type: UnificationXref
id: 8364
db: ncbitaxon

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
type: ProteinReference
xref: uniprot P13995 31
organism: Homo sapiens

ncbitaxon 190304 50
type: UnificationXref
id: 190304
db: ncbitaxon

uniprot P12461 110
type: UnificationXref
id: P12461
db: uniprot

Dihydrofolate reductase
type: Protein
entity reference: Dihydrofolate reductase
comment: SPECIES_TYPE=PROTEIN

uniprot O34990 129
type: UnificationXref
id: O34990
db: uniprot

Folyl-polyglutamate synthetase
type: ProteinReference
xref: uniprot Q9RXH3 165
organism: Deinococcus radiodurans

uniprot Q9RWT1 137
type: UnificationXref
id: Q9RWT1
db: uniprot

ncbitaxon 64091 56
type: UnificationXref
id: 64091
db: ncbitaxon

Uncharacterized protein
type: ProteinReference
xref: uniprot F6ZRA0 97
organism: Macaca mulatta

Thymidylate synthase
type: Protein
entity reference: Thymidylate synthase
comment: SPECIES_TYPE=PROTEIN

STATE_TRANSITION_LEFT__H2O-_10_formyl_THF-RIGHT__formate-_THF-_r7
type: BiochemicalReaction
conversion direction: LEFT_TO_RIGHT
xref: STATE TRANSITION
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 171
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 172
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 173
participant stoichiometry: PARTICIPANT STOICHIOMETRY r7 174
left: 10-formyl-THF
left: H2O
interaction type: STATE_TRANSITION
right: THF
right: formate

Deinococcus radiodurans
type: BioSource
xref: ncbitaxon 243230 63

ncbitaxon 9544 18
type: UnificationXref
id: 9544
db: ncbitaxon

Homo sapiens
type: BioSource
xref: ncbitaxon 9606 32

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
type: ProteinReference
xref: uniprot P18155 33
organism: Mus musculus

Bifunctional protein FolD 4, chloroplastic
type: ProteinReference
xref: uniprot O65271 24
organism: Arabidopsis thaliana

CATALYSIS
type: Catalysis
controlled: STATE_TRANSITION_LEFT__5,10_methenyl_THF-_H2O-RIGHT__10_formyl_THF-_r6
controller: Methylene tetrahydrofolate dehydrogenase

uniprot Q9I6E3 154
type: UnificationXref
id: Q9I6E3
db: uniprot

uniprot Q7Q0L5 150
type: UnificationXref
id: Q7Q0L5
db: uniprot

Dihydrofolate reductase
type: ProteinReference
xref: P02957
comment: ENTITY_REFERENCE_PROTEIN_TYPE=GENERIC
comment: ENTITY_REFERENCE_ID_DESC=Formyltetrahydroformate biosynthesis.PROTEIN.GENERIC.Dihydrofolate reductase
comment: ENTITY_REFERENCE_NOTES=Long Name: Dihydrofolate reductase Synonym: Synonym not specified Accession: P02957
member entity reference: Thymidylate synthase
member entity reference: Uncharacterized protein
member entity reference: Probable thymidylate synthase
member entity reference: Bifunctional dihydrofolate reductase-thymidylate synthase
member entity reference: Thymidylate synthase 1
member entity reference: Bifunctional dihydrofolate reductase-thymidylate synthase 1
member entity reference: AGAP010457-PA
member entity reference: Thymidylate synthase ThyA
member entity reference: DHFR isoform 1
member entity reference: Dihydrofolate reductase
member entity reference: Thymidylate synthase 2
member entity reference: Fibronectin 1
member entity reference: Dihydrofolate reductase 2, mitochondrial
member entity reference: Putative dihydrofolate reductase
member entity reference: Thymidylate synthetase
member entity reference: AGAP010278-PA

uniprot Q582G3 115
type: UnificationXref
id: Q582G3
db: uniprot

Arabidopsis thaliana
type: BioSource
xref: ncbitaxon 3702 5

uniprot O84081 27
type: UnificationXref
id: O84081
db: uniprot

uniprot Q9WY13 166
type: UnificationXref
id: Q9WY13
db: uniprot

Bifunctional protein FolD 3, chloroplastic
type: ProteinReference
xref: uniprot O65269 23
organism: Arabidopsis thaliana

7,8-dihydropteroate
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

Dihydrofolate reductase
type: ProteinReference
xref: uniprot P36591 147
organism: Schizosaccharomyces pombe

Formyltetrahydrofolate deformylase
type: ProteinReference
xref: uniprot Q9HNU0 134
organism: Halobacterium salinarum

homocysteine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9RR65 155
type: UnificationXref
id: Q9RR65
db: uniprot

Mycobacterium tuberculosis
type: BioSource
xref: ncbitaxon 83332 40

uniprot G2HEY4 98
type: UnificationXref
id: G2HEY4
db: uniprot

uniprot Q5WN02 46
type: UnificationXref
id: Q5WN02
db: uniprot

Escherichia coli
type: BioSource
xref: ncbitaxon 83333 36

Danio rerio
type: BioSource
xref: ncbitaxon 7955 118

Bifunctional protein FolD
type: ProteinReference
xref: uniprot Q9I2U6 57
organism: Pseudomonas aeruginosa

ncbitaxon 6945 11
type: UnificationXref
id: 6945
db: ncbitaxon

Os05g0150800 protein
type: ProteinReference
xref: uniprot Q5WN02 46
organism: Oryza sativa

uniprot P54382 37
type: UnificationXref
id: P54382
db: uniprot

PO4
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot E2RQ65 14
type: UnificationXref
id: E2RQ65
db: uniprot

uniprot P9WHM3 132
type: UnificationXref
id: P9WHM3
db: uniprot

Formyl tetrahydrofolate deformylase
type: Protein
entity reference: Formyl tetrahydrofolate deformylase
comment: SPECIES_TYPE=PROTEIN

Thymidylate synthase
type: ProteinReference
xref: uniprot Q9I6F1 123
organism: Pseudomonas aeruginosa

uniprot P37051 131
type: UnificationXref
id: P37051
db: uniprot

uniprot Q9EWH3 88
type: UnificationXref
id: Q9EWH3
db: uniprot

ncbitaxon 83333 36
type: UnificationXref
id: 83333
db: ncbitaxon

uniprot O76511 99
type: UnificationXref
id: O76511
db: uniprot

uniprot Q9HNU0 134
type: UnificationXref
id: Q9HNU0
db: uniprot

uniprot P07807 144
type: UnificationXref
id: P07807
db: uniprot

Fusobacterium nucleatum
type: BioSource
xref: ncbitaxon 190304 50

Formyltetrahydrofolate deformylase
type: ProteinReference
xref: uniprot Q9HTE4 135
organism: Pseudomonas aeruginosa

ncbitaxon 272561 28
type: UnificationXref
id: 272561
db: ncbitaxon

uniprot Q9SDL7 92
type: UnificationXref
id: Q9SDL7
db: uniprot

uniprot Q7QDW7 119
type: UnificationXref
id: Q7QDW7
db: uniprot

uniprot A6H5Y3 66
type: UnificationXref
id: A6H5Y3
db: uniprot

Trypanosoma brucei
type: BioSource
xref: ncbitaxon 185431 116

uniprot A8XQ07 6
type: UnificationXref
id: A8XQ07
db: uniprot

Bifunctional protein FolD
type: ProteinReference
xref: uniprot P24186 35
organism: Escherichia coli

uniprot B3DL74 8
type: UnificationXref
id: B3DL74
db: uniprot

Bifunctional protein FolD 1, mitochondrial
type: ProteinReference
xref: uniprot A2RVV7 4
organism: Arabidopsis thaliana

NADP
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot P11044 109
type: UnificationXref
id: P11044
db: uniprot

ncbitaxon 237561 111
type: UnificationXref
id: 237561
db: ncbitaxon

uniprot Q9I2U6 57
type: UnificationXref
id: Q9I2U6
db: uniprot

Formyltetrahydrofolate deformylase
type: ProteinReference
xref: uniprot O67681 130
organism: Aquifex aeolicus

Methionine synthase
type: ProteinReference
xref: uniprot E2R716 67
organism: Canis lupus familiaris

Dihydrofolate synthase/folylpolyglutamate synthase
type: ProteinReference
xref: uniprot Q05865 159
organism: Bacillus subtilis

methionine
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

CG10623 protein
type: ProteinReference
xref: uniprot Q9VJ31 93
organism: Drosophila melanogaster

FI01821p
type: ProteinReference
xref: uniprot Q9VJ32 94
organism: Drosophila melanogaster

Rattus norvegicus
type: BioSource
xref: ncbitaxon 10116 13

Dihydrofolate reductase
type: ProteinReference
xref: uniprot Q9I6E3 154
organism: Pseudomonas aeruginosa

Bifunctional protein FolD
type: ProteinReference
xref: uniprot Q9HPY4 55
organism: Halobacterium salinarum

uniprot B7P898 10
type: UnificationXref
id: B7P898
db: uniprot

uniprot Q9X288 64
type: UnificationXref
id: Q9X288
db: uniprot

5,10-Methylene tetrahydrofolate reductase
type: Protein
comment: SPECIES_TYPE=PROTEIN

uniprot H2R7Z7 69
type: UnificationXref
id: H2R7Z7
db: uniprot

uniprot P45352 112
type: UnificationXref
id: P45352
db: uniprot

uniprot Q55135 133
type: UnificationXref
id: Q55135
db: uniprot

Cobalamin dependent homocysteine transmethylase
type: Protein
entity reference: Cobalamin dependent homocysteine transmethylase
comment: SPECIES_TYPE=PROTEIN

Thymidylate synthase
type: ProteinReference
xref: uniprot P45352 112
organism: Rattus norvegicus

ncbitaxon 214684 108
type: UnificationXref
id: 214684
db: ncbitaxon

uniprot Q920D2 152
type: UnificationXref
id: Q920D2
db: uniprot

uniprot D4A1Y5 12
type: UnificationXref
id: D4A1Y5
db: uniprot

Uncharacterized protein
type: ProteinReference
xref: uniprot E2RQ65 14
organism: Canis lupus familiaris

STATE_TRANSITION
type: InteractionVocabulary

uniprot Q8RGP6 122
type: UnificationXref
id: Q8RGP6
db: uniprot

Folylpolyglutamate synthetase
type: ProteinReference
xref: uniprot Q9HZA8 163
organism: Pseudomonas aeruginosa

H2O
type: SmallMolecule
comment: SPECIES_TYPE=SIMPLE_MOLECULE

uniprot Q9SIK4 126
type: UnificationXref
id: Q9SIK4
db: uniprot

uniprot Q9M1W4 90
type: UnificationXref
id: Q9M1W4
db: uniprot

uniprot O67736 25
type: UnificationXref
id: O67736
db: uniprot

Candida albicans
type: BioSource
xref: ncbitaxon 237561 111

uniprot Q8I1R6 120
type: UnificationXref
id: Q8I1R6
db: uniprot

PARTICIPANT STOICHIOMETRY r4 197
type: Stoichiometry
physical entity: 5-methyltetrahydrofolate
stoichiometric coefficient: 1.0

Thymidylate synthase
type: ProteinReference
xref: uniprot P06785 101
organism: Saccharomyces cerevisiae

PARTICIPANT STOICHIOMETRY r4 196
type: Stoichiometry
physical entity: homocysteine
stoichiometric coefficient: 1.0

uniprot Q9Z2Q4 96
type: UnificationXref
id: Q9Z2Q4
db: uniprot

Leishmania major
type: BioSource
xref: ncbitaxon 5664 103

Formyltetrahydrofolate deformylase
type: ProteinReference
xref: uniprot P9WHM3 132
organism: Mycobacterium tuberculosis

Homocysteine S-methyltransferase 2
type: ProteinReference
xref: uniprot Q9M1W4 90
organism: Arabidopsis thaliana

uniprot O96553 29
type: UnificationXref
id: O96553
db: uniprot

ncbitaxon 6238 7
type: UnificationXref
id: 6238
db: ncbitaxon

uniprot F7G8N5 19
type: UnificationXref
id: F7G8N5
db: uniprot

ncbitaxon 224308 38
type: UnificationXref
id: 224308
db: ncbitaxon

PARTICIPANT STOICHIOMETRY r4 198
type: Stoichiometry
physical entity: methionine
stoichiometric coefficient: 1.0

Bifunctional dihydrofolate reductase-thymidylate synthase 1
type: ProteinReference
xref: uniprot Q05762 114
organism: Arabidopsis thaliana

PARTICIPANT STOICHIOMETRY r4 199
type: Stoichiometry
physical entity: THF
stoichiometric coefficient: 1.0

ncbitaxon 9598 21
type: UnificationXref
id: 9598
db: ncbitaxon

Thymidylate synthase 1
type: ProteinReference
xref: uniprot P0CI79 106
organism: Bacillus subtilis

uniprot F4J2K2 156
type: UnificationXref
id: F4J2K2
db: uniprot

uniprot H2QR61 140
type: UnificationXref
id: H2QR61
db: uniprot

Fibronectin 1
type: ProteinReference
xref: uniprot G2HEY4 98
organism: Pan troglodytes